BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] (449 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 917 0.0 gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 907 0.0 gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 160 2e-39 gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 117 2e-26 gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 117 2e-26 gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 117 2e-26 gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 106 4e-23 gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 57 3e-08 gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 56 8e-08 gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 56 8e-08 gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 56 8e-08 gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 56 8e-08 gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 49 7e-06 gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 49 7e-06 gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 47 5e-05 gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 47 5e-05 gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 45 2e-04 gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 45 2e-04 gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 45 2e-04 gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 32 1.2 gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 32 1.2 gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 32 1.5 gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 32 1.5 gi|153792780 additional sex combs like 2 [Homo sapiens] 30 3.4 gi|158508542 kelch-like 33 [Homo sapiens] 30 4.4 gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 30 4.4 gi|11225260 DNA topoisomerase I [Homo sapiens] 29 7.6 gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens] 29 7.6 gi|21361378 sarcosine dehydrogenase precursor [Homo sapiens] 29 7.6 gi|31563374 eukaryotic translation initiation factor 6 isoform c... 29 7.6 >gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] Length = 449 Score = 917 bits (2369), Expect = 0.0 Identities = 449/449 (100%), Positives = 449/449 (100%) Query: 1 MADGEEPMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLV 60 MADGEEPMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLV Sbjct: 1 MADGEEPMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLV 60 Query: 61 IGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLND 120 IGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLND Sbjct: 61 IGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLND 120 Query: 121 RVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSS 180 RVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSS Sbjct: 121 RVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSS 180 Query: 181 IVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVR 240 IVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVR Sbjct: 181 IVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVR 240 Query: 241 MLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVA 300 MLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVA Sbjct: 241 MLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVA 300 Query: 301 STNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNI 360 STNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNI Sbjct: 301 STNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNI 360 Query: 361 QFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLK 420 QFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLK Sbjct: 361 QFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLK 420 Query: 421 ELGLVDGQELAVADVTTPQTVLFKLHFTS 449 ELGLVDGQELAVADVTTPQTVLFKLHFTS Sbjct: 421 ELGLVDGQELAVADVTTPQTVLFKLHFTS 449 >gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] Length = 463 Score = 907 bits (2344), Expect = 0.0 Identities = 449/463 (96%), Positives = 449/463 (96%), Gaps = 14/463 (3%) Query: 1 MADGEEP--------------MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 46 MADGEEP MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST Sbjct: 1 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 60 Query: 47 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 106 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI Sbjct: 61 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 120 Query: 107 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 166 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI Sbjct: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 180 Query: 167 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 226 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA Sbjct: 181 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 240 Query: 227 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 286 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR Sbjct: 241 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 300 Query: 287 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 346 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER Sbjct: 301 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 360 Query: 347 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 406 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS Sbjct: 361 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 420 Query: 407 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 449 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS Sbjct: 421 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 463 >gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] Length = 640 Score = 160 bits (406), Expect = 2e-39 Identities = 99/236 (41%), Positives = 135/236 (57%), Gaps = 19/236 (8%) Query: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 116 +VLV+GAGG+GCELLKNL L+GF I +ID+DTIDVSNLNRQFLF+ K +GR KA+VA E Sbjct: 19 RVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKE 78 Query: 117 FLNDRVPNCNVVPHFNKIQ--DFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDG 174 + P N+V + + I D+N F+RQF +++ LD+ AR +N M + Sbjct: 79 SVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCL-------- 130 Query: 175 VLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEH 234 ++ VPLI+ GT G+ G I G+T C EC + P Q FP CTI + P P H Sbjct: 131 ----AADVPLIESGTAGYLGQVTTIKKGVTECYECHPK--PTQRTFPGCTIRNTPSEPIH 184 Query: 235 CIEYVRML--QWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLT 288 CI + + L Q E+ + V D DPE W ++ RA N G R++ Sbjct: 185 CIVWAKYLFNQLFGEEDADQEVSPDRADPE-AAWEPTEAEARARASNEDGDIKRIS 239 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/227 (23%), Positives = 87/227 (38%), Gaps = 15/227 (6%) Query: 225 IASMPRLPEHCIEYVRMLQWPKEQPFGEGVPL--DGDDPEHIQWIFQKSLERASQYNIRG 282 + S RL IE +R+ K G+G L D DDP + ++ + R +++ Sbjct: 315 VKSYARLFSKSIETLRVHLAEK----GDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM 370 Query: 283 VTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVF---NDVDGLYT 339 + + + IIPA+A+TNAVIA + E KI + + N L Sbjct: 371 KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLV 430 Query: 340 YTFEAERKENCPACSQLPQ-NIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRT 398 NC C+ P+ ++ + L M +P + +GK Sbjct: 431 PCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIE-DGKGTI 489 Query: 399 LYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKL 445 L ++S E T N K L E G+ +G L D T+L + Sbjct: 490 L----ISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINI 532 >gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] Length = 1058 Score = 117 bits (293), Expect = 2e-26 Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%) Query: 49 LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 103 LQ L K ++GAG +GCELLKN A+ G +I V DMDTI+ SNLNRQFLFRP Sbjct: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521 Query: 104 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 158 D+ + K++ AA + P+ V H N++ + ++D F++ + LD++ AR Sbjct: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581 Query: 159 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 218 +++ + PL++ GT G KGN +V++P +T + + PP+ Sbjct: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627 Query: 219 NFPMCTIASMPRLPEHCIEYVR 240 + P+CT+ + P EH +++ R Sbjct: 628 SIPICTLKNFPNAIEHTLQWAR 649 Score = 52.0 bits (123), Expect = 1e-06 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L T VLV G GLG E+ KN+ L G + + + D T ++L+ QF R +DIG+ +AE Sbjct: 70 LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129 Query: 113 VA----AEFLNDRVP 123 V+ AE LN VP Sbjct: 130 VSQPRLAE-LNSYVP 143 Score = 37.4 bits (85), Expect = 0.028 Identities = 18/61 (29%), Positives = 32/61 (52%) Query: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316 D D H+ +I S RA Y+I ++ + +IIPA+A+T A + + E++K Sbjct: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911 Query: 317 I 317 + Sbjct: 912 V 912 >gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] Length = 1058 Score = 117 bits (293), Expect = 2e-26 Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%) Query: 49 LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 103 LQ L K ++GAG +GCELLKN A+ G +I V DMDTI+ SNLNRQFLFRP Sbjct: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521 Query: 104 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 158 D+ + K++ AA + P+ V H N++ + ++D F++ + LD++ AR Sbjct: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581 Query: 159 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 218 +++ + PL++ GT G KGN +V++P +T + + PP+ Sbjct: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627 Query: 219 NFPMCTIASMPRLPEHCIEYVR 240 + P+CT+ + P EH +++ R Sbjct: 628 SIPICTLKNFPNAIEHTLQWAR 649 Score = 52.0 bits (123), Expect = 1e-06 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L T VLV G GLG E+ KN+ L G + + + D T ++L+ QF R +DIG+ +AE Sbjct: 70 LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129 Query: 113 VA----AEFLNDRVP 123 V+ AE LN VP Sbjct: 130 VSQPRLAE-LNSYVP 143 Score = 37.4 bits (85), Expect = 0.028 Identities = 18/61 (29%), Positives = 32/61 (52%) Query: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316 D D H+ +I S RA Y+I ++ + +IIPA+A+T A + + E++K Sbjct: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911 Query: 317 I 317 + Sbjct: 912 V 912 >gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] Length = 1052 Score = 117 bits (293), Expect = 2e-26 Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 25/199 (12%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFR------QIHVIDMDTIDVSNLNRQFLFRPKDI 106 L + ++G G +GCE+LKN AL G I V D D I+ SNLNRQFLFRP I Sbjct: 458 LQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHI 517 Query: 107 GRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIARRWI 161 +PK+ AA+ + H NK+ +ND FY + +I+ LD++ ARR++ Sbjct: 518 QKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYV 577 Query: 162 NGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFP 221 + ++ L PL+D GT G KG+ VI+P +T + PP+ P Sbjct: 578 DSRCLANLR------------PLLDSGTMGTKGHTEVIVPHLTESYNSHRD--PPEEEIP 623 Query: 222 MCTIASMPRLPEHCIEYVR 240 CT+ S P EH I++ R Sbjct: 624 FCTLKSFPAAIEHTIQWAR 642 Score = 40.0 bits (92), Expect = 0.004 Identities = 21/61 (34%), Positives = 33/61 (54%) Query: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316 D D HI +I S RA Y+I T+ + +IIPA+A+T A ++ + A E+ K Sbjct: 852 DDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIK 911 Query: 317 I 317 + Sbjct: 912 V 912 Score = 38.1 bits (87), Expect = 0.016 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 7/87 (8%) Query: 58 VLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI--GRPKAEVAA 115 V + G GGLG E+ KNL L+G + + + D + +L F D+ R +AE Sbjct: 64 VFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVL 123 Query: 116 EFLNDRVPNCNV----VPHFNKIQDFN 138 + + + P +V VP FN+ D + Sbjct: 124 KHIAELNPYVHVTSSSVP-FNETTDLS 149 >gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sapiens] Length = 1012 Score = 106 bits (265), Expect = 4e-23 Identities = 66/193 (34%), Positives = 96/193 (49%), Gaps = 23/193 (11%) Query: 59 LVIGAGGLGCELLKNLALSGFRQ-----IHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEV 113 L++GAG +GCELLK AL G + V+DMD I+ SNL+RQFLFR +D+GRPKAEV Sbjct: 436 LLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEV 495 Query: 114 AAEFLNDRVPNCNVVPHFNKIQD-----FNDTFYRQFHIIVCGLDSIIARRWINGMLISL 168 AA P+ V+P + + D F+ + + LDS ARR++ Sbjct: 496 AAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHY 555 Query: 169 LNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQ-VNFPMCTIAS 227 L PL++ GT G G+A V +P +T + +P+CT+ Sbjct: 556 LK------------PLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRY 603 Query: 228 MPRLPEHCIEYVR 240 P EH +++ R Sbjct: 604 FPSTAEHTLQWAR 616 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 3/93 (3%) Query: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 116 +VLV G GLG E+ KNL L G + + D S+L QFL +D+ R +AE + E Sbjct: 34 RVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSRAEASQE 93 Query: 117 FLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 149 L VV H D + F ++V Sbjct: 94 LLAQLNRAVQVVVHTG---DITEDLLLDFQVVV 123 Score = 39.7 bits (91), Expect = 0.006 Identities = 18/63 (28%), Positives = 34/63 (53%) Query: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316 D D H+ ++ + R Y I V ++ +V +IIPA+A+T A +A + E++K Sbjct: 811 DDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYK 870 Query: 317 IAT 319 + + Sbjct: 871 VVS 873 >gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] Length = 460 Score = 57.0 bits (136), Expect = 3e-08 Identities = 45/175 (25%), Positives = 69/175 (39%), Gaps = 13/175 (7%) Query: 50 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 109 Q L T VL++G GGLGC L + LA +G ++ ++D D +++SNL RQ L G+ Sbjct: 77 QLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQA 136 Query: 110 KAEVAAEFLNDRVPNCNVVPHFNKIQDFND-TFYRQFHIIVCGLDSIIARRWINGMLISL 168 KA AA L VP+ + R++ ++ D++ R +N + Sbjct: 137 KAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLA 196 Query: 169 LNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMC 223 PL+ F+G V C C PP C Sbjct: 197 GR------------PLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNC 239 >gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo sapiens] Length = 266 Score = 55.8 bits (133), Expect = 8e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 Query: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 >gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo sapiens] Length = 299 Score = 55.8 bits (133), Expect = 8e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 Query: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 >gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] Length = 346 Score = 55.8 bits (133), Expect = 8e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 Query: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 >gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] Length = 346 Score = 55.8 bits (133), Expect = 8e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 Query: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 >gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo sapiens] Length = 528 Score = 49.3 bits (116), Expect = 7e-06 Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%) Query: 50 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 109 Q L++ V +I A G E+LKNL L G +ID + + + F + IG+ Sbjct: 19 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKN 78 Query: 110 KAEVAAEF---LNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 149 +AE A EF LN V V + D + +F+ +F ++V Sbjct: 79 RAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV 121 >gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo sapiens] Length = 534 Score = 49.3 bits (116), Expect = 7e-06 Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%) Query: 50 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 109 Q L++ V +I A G E+LKNL L G +ID + + + F + IG+ Sbjct: 25 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKN 84 Query: 110 KAEVAAEF---LNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 149 +AE A EF LN V V + D + +F+ +F ++V Sbjct: 85 RAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV 127 >gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] Length = 348 Score = 46.6 bits (109), Expect = 5e-05 Identities = 46/180 (25%), Positives = 74/180 (41%), Gaps = 34/180 (18%) Query: 55 TCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVA 114 T V ++G GG+G + L G ++ + D D ++++N+NR F F+P G K + A Sbjct: 17 TFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAA 75 Query: 115 AEFLND-------RVPNCNVVPHFNKIQDFNDTFY-------RQFHIIVCGLDSIIARRW 160 L + V N N+ N Q F D + +++ +D+ AR Sbjct: 76 EHTLRNINPDVLFEVHNYNITTVEN-FQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMT 134 Query: 161 INGMLISLLN--YEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 218 IN L E GV + G+ ++I+PG +AC C PP V Sbjct: 135 INTACNELGQTWMESGVSE------------NAVSGHIQLIIPGESACFACA----PPLV 178 >gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] Length = 404 Score = 46.6 bits (109), Expect = 5e-05 Identities = 46/180 (25%), Positives = 74/180 (41%), Gaps = 34/180 (18%) Query: 55 TCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVA 114 T V ++G GG+G + L G ++ + D D ++++N+NR F F+P G K + A Sbjct: 73 TFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAA 131 Query: 115 AEFLND-------RVPNCNVVPHFNKIQDFNDTFY-------RQFHIIVCGLDSIIARRW 160 L + V N N+ N Q F D + +++ +D+ AR Sbjct: 132 EHTLRNINPDVLFEVHNYNITTVEN-FQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMT 190 Query: 161 INGMLISLLN--YEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 218 IN L E GV + G+ ++I+PG +AC C PP V Sbjct: 191 INTACNELGQTWMESGVSE------------NAVSGHIQLIIPGESACFACA----PPLV 234 >gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] Length = 623 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%) Query: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 113 K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA Sbjct: 318 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 377 Query: 114 AAEFLNDRVPNCN 126 AA+ L P N Sbjct: 378 AADRLQKIFPGVN 390 >gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] Length = 676 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%) Query: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 113 K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416 Query: 114 AAEFLNDRVPNCN 126 AA+ L P N Sbjct: 417 AADRLQKIFPGVN 429 >gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] Length = 703 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%) Query: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 113 K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416 Query: 114 AAEFLNDRVPNCN 126 AA+ L P N Sbjct: 417 AADRLQKIFPGVN 429 >gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo sapiens] Length = 1250 Score = 32.0 bits (71), Expect = 1.2 Identities = 26/122 (21%), Positives = 52/122 (42%), Gaps = 18/122 (14%) Query: 328 YLVFNDVDGLYTYTFEAERKEN---------CPACSQLPQNIQFSPSA-----KLQEVLD 373 + +FN + GL+ + F KEN C +L N +S +A K + L Sbjct: 1099 FSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLG 1158 Query: 374 YLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVA 433 +S+S+ S +T+ + + T + ++ ++ K+L +L DG + ++ Sbjct: 1159 KSLSSSSIGSNSTYLTSKSKSSSTTYFKRN----SHTDSASMDKSLSKLAHADGDQTSII 1214 Query: 434 DV 435 V Sbjct: 1215 PV 1216 >gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo sapiens] Length = 1222 Score = 32.0 bits (71), Expect = 1.2 Identities = 26/122 (21%), Positives = 52/122 (42%), Gaps = 18/122 (14%) Query: 328 YLVFNDVDGLYTYTFEAERKEN---------CPACSQLPQNIQFSPSA-----KLQEVLD 373 + +FN + GL+ + F KEN C +L N +S +A K + L Sbjct: 1071 FSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLG 1130 Query: 374 YLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVA 433 +S+S+ S +T+ + + T + ++ ++ K+L +L DG + ++ Sbjct: 1131 KSLSSSSIGSNSTYLTSKSKSSSTTYFKRN----SHTDSASMDKSLSKLAHADGDQTSII 1186 Query: 434 DV 435 V Sbjct: 1187 PV 1188 >gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] Length = 823 Score = 31.6 bits (70), Expect = 1.5 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 2/67 (2%) Query: 353 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPA--ITATLEGKNRTLYLQSVTSIEER 410 C +Q+ S +L +V+DY+ AS+ PA +E +N+ L +S E Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQERE 175 Query: 411 TRPNLSK 417 + N++K Sbjct: 176 KKENMAK 182 >gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] Length = 823 Score = 31.6 bits (70), Expect = 1.5 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 2/67 (2%) Query: 353 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPA--ITATLEGKNRTLYLQSVTSIEER 410 C +Q+ S +L +V+DY+ AS+ PA +E +N+ L +S E Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQERE 175 Query: 411 TRPNLSK 417 + N++K Sbjct: 176 KKENMAK 182 >gi|153792780 additional sex combs like 2 [Homo sapiens] Length = 1435 Score = 30.4 bits (67), Expect = 3.4 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 7/95 (7%) Query: 346 RKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVT 405 RKE C + ++ N S L L+ S+ L +K P LE K VT Sbjct: 443 RKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPIKCPKDEDLLEQK-------PVT 495 Query: 406 SIEERTRPNLSKTLKELGLVDGQELAVADVTTPQT 440 S E+ + N T + QE V + P++ Sbjct: 496 SAEQESEKNHLTTASNYNKSESQESLVTSPSKPKS 530 >gi|158508542 kelch-like 33 [Homo sapiens] Length = 453 Score = 30.0 bits (66), Expect = 4.4 Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 3/63 (4%) Query: 5 EEPMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAG 64 E + V GGCG TG + H LE+ G F P P + L + AG Sbjct: 288 EGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGG---RLYVAG 344 Query: 65 GLG 67 GLG Sbjct: 345 GLG 347 >gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] Length = 822 Score = 30.0 bits (66), Expect = 4.4 Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 1/66 (1%) Query: 353 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSP-AITATLEGKNRTLYLQSVTSIEERT 411 C +Q+ S +L +V+DY+ AS+ P +E +N+ L +S E Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPEKDNGNIELENKKLEKESKNEQEREK 175 Query: 412 RPNLSK 417 + N++K Sbjct: 176 KENMAK 181 >gi|11225260 DNA topoisomerase I [Homo sapiens] Length = 765 Score = 29.3 bits (64), Expect = 7.6 Identities = 12/26 (46%), Positives = 16/26 (61%) Query: 29 KFLERSGPFTHPDFEPSTESLQFLLD 54 KFLE GP P +EP E+++F D Sbjct: 218 KFLEHKGPVFAPPYEPLPENVKFYYD 243 >gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens] Length = 918 Score = 29.3 bits (64), Expect = 7.6 Identities = 14/27 (51%), Positives = 17/27 (62%) Query: 52 LLDTCKVLVIGAGGLGCELLKNLALSG 78 L T V+VIG G LGC+ L +LA G Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLG 89 >gi|21361378 sarcosine dehydrogenase precursor [Homo sapiens] Length = 918 Score = 29.3 bits (64), Expect = 7.6 Identities = 14/27 (51%), Positives = 17/27 (62%) Query: 52 LLDTCKVLVIGAGGLGCELLKNLALSG 78 L T V+VIG G LGC+ L +LA G Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLG 89 >gi|31563374 eukaryotic translation initiation factor 6 isoform c [Homo sapiens] Length = 226 Score = 29.3 bits (64), Expect = 7.6 Identities = 19/71 (26%), Positives = 34/71 (47%), Gaps = 7/71 (9%) Query: 294 RIIPAVASTNA-------VIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 346 R+ PA AS+ A ++A V EVF+ + + + +Y VF++ GL E Sbjct: 91 RLSPAAASSGACVWETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIED 150 Query: 347 KENCPACSQLP 357 ++ + Q+P Sbjct: 151 QDELSSLLQVP 161 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.138 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,627,931 Number of Sequences: 37866 Number of extensions: 798700 Number of successful extensions: 1807 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 8 Number of HSP's that attempted gapping in prelim test: 1751 Number of HSP's gapped (non-prelim): 45 length of query: 449 length of database: 18,247,518 effective HSP length: 106 effective length of query: 343 effective length of database: 14,233,722 effective search space: 4882166646 effective search space used: 4882166646 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.