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Search of human proteins with 34734068
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
(566 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 1234 0.0
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 1234 0.0
gi|34734066 fibulin 1 isoform D [Homo sapiens] 1234 0.0
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 1234 0.0
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 533 e-151
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 511 e-145
gi|118572606 hemicentin 1 [Homo sapiens] 269 6e-72
gi|46249414 latent transforming growth factor beta binding prote... 256 3e-68
gi|46249412 latent transforming growth factor beta binding prote... 256 3e-68
gi|56237021 fibrillin 3 precursor [Homo sapiens] 251 1e-66
gi|24430141 fibrillin 1 precursor [Homo sapiens] 250 2e-66
gi|110347437 latent transforming growth factor beta binding prot... 239 4e-63
gi|110347412 latent transforming growth factor beta binding prot... 239 4e-63
gi|110347431 latent transforming growth factor beta binding prot... 239 4e-63
gi|66346695 fibrillin 2 precursor [Homo sapiens] 231 1e-60
gi|19743803 fibulin 5 precursor [Homo sapiens] 230 3e-60
gi|4557733 latent transforming growth factor beta binding protei... 228 1e-59
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 224 2e-58
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 215 8e-56
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 206 5e-53
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 206 5e-53
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 204 2e-52
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 204 2e-52
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 204 2e-52
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 202 7e-52
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 202 7e-52
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 202 7e-52
gi|194328809 latent transforming growth factor beta binding prot... 200 3e-51
gi|18497288 latent transforming growth factor beta binding prote... 200 3e-51
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 197 3e-50
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 1234 bits (3194), Expect = 0.0
Identities = 566/566 (100%), Positives = 566/566 (100%)
Query: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
Query: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
TCFNIQGGFRCLAFECPENYRRSAAT
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 1234 bits (3194), Expect = 0.0
Identities = 566/566 (100%), Positives = 566/566 (100%)
Query: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
Query: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
TCFNIQGGFRCLAFECPENYRRSAAT
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 1234 bits (3194), Expect = 0.0
Identities = 566/566 (100%), Positives = 566/566 (100%)
Query: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
Query: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
TCFNIQGGFRCLAFECPENYRRSAAT
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 1234 bits (3194), Expect = 0.0
Identities = 566/566 (100%), Positives = 566/566 (100%)
Query: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
Query: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
TCFNIQGGFRCLAFECPENYRRSAAT
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 533 bits (1374), Expect = e-151
Identities = 225/387 (58%), Positives = 281/387 (72%), Gaps = 3/387 (0%)
Query: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
C+ GPCKQ C G +CSCF GY +++DGVSCED+NEC+T H+C GE C+NT+GS
Sbjct: 683 CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGS 742
Query: 240 FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
F C + +C GY L +D C+D+DEC G H C P F+CQNT GSF C+ + +C GF+
Sbjct: 743 FHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 801
Query: 300 QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359
QD GNC+DINEC S+S PC G +CINT GSYTCQ+N C RGYH +++GT+CVDV+E
Sbjct: 802 QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNE 861
Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
C CG+G C N PGS+RC+CK G+ D R C+DVNEC PGRLC H CENTL
Sbjct: 862 CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTL 921
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
GSY CSC+ GF L+ DG+ CED+NEC + CSQECAN+YGSYQCYCR+GYQL++ DG TC
Sbjct: 922 GSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DGHTC 980
Query: 480 EDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
DIDECA G +C++RC+N+PGS+QC+CP GY + NGR+C+D+DEC G HNCS
Sbjct: 981 TDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1039
Query: 540 ETCFNIQGGFRCLAFECPENYRRSAAT 566
ETC NIQG FRCL FECP NY + + T
Sbjct: 1040 ETCHNIQGSFRCLRFECPPNYVQVSKT 1066
Score = 120 bits (301), Expect = 3e-27
Identities = 114/373 (30%), Positives = 148/373 (39%), Gaps = 73/373 (19%)
Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ---C 294
GS + ++ C G + DN DEC + D +C+ T C LQ C
Sbjct: 436 GSTKDLIETCCAAGQQWAIDN-----DECLEIPESGTEDNVCR-TAQRHCCVSYLQEKSC 489
Query: 295 KSGFIQDALGNCI--DINECLSISAPCPIGHTC-----INTEGSYTCQKNVPNCGRGYHL 347
+G + G + N+ IS C + EG +C+ N PN G Y
Sbjct: 490 MAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ-SCESN-PNLG--YPC 545
Query: 348 NE------EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-V 400
N EG + V E P EP R + + R G + + + D
Sbjct: 546 NHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQ 605
Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE-------------------- 440
+EC PG LC H C NT+GSY C+C GF L DGR+C
Sbjct: 606 DECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665
Query: 441 -------------DINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
N C + PC Q C+ V GS C C GY + DGV+CEDI+EC
Sbjct: 666 SQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM-ADGVSCEDINECV 724
Query: 487 LPTGGHICS--YRCINIPGSFQC----SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
T H CS C+N GSF C +C GY L C+D+DEC G H C
Sbjct: 725 --TDLHTCSRGEHCVNTLGSFHCYKALTC-EPGYALKDG--ECEDVDECAMGTHTCQPGF 779
Query: 541 TCFNIQGGFRCLA 553
C N +G F C A
Sbjct: 780 LCQNTKGSFYCQA 792
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 511 bits (1316), Expect = e-145
Identities = 225/434 (51%), Positives = 281/434 (64%), Gaps = 50/434 (11%)
Query: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED----------------------- 216
C+ GPCKQ C G +CSCF GY +++DGVSCED
Sbjct: 683 CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGS 742
Query: 217 ------------------------VNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY 252
+NEC+T H+C GE C+NT+GSF C + +C GY
Sbjct: 743 FYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802
Query: 253 ELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC 312
L +D C+D+DEC G H C P F+CQNT GSF C+ + +C GF+QD GNC+DINEC
Sbjct: 803 AL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINEC 861
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
S+S PC G +CINT GSYTCQ+N C RGYH +++GT+CVDV+EC CG+G
Sbjct: 862 TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 921
Query: 373 CVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL 432
C N PGS+RC+CK G+ D R C+DVNEC PGRLC H CENTLGSY CSC+ GF L
Sbjct: 922 CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL 981
Query: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
+ DG+ CED+NEC + CSQECAN+YGSYQCYCR+GYQL++ DG TC DIDECA G
Sbjct: 982 AADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DGHTCTDIDECA-QGAGI 1039
Query: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
+C++RC+N+PGS+QC+CP GY + NGR+C+D+DEC G HNCS ETC NIQG FRCL
Sbjct: 1040 LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1099
Query: 553 AFECPENYRRSAAT 566
FECP NY + + T
Sbjct: 1100 RFECPPNYVQVSKT 1113
Score = 128 bits (322), Expect = 1e-29
Identities = 120/381 (31%), Positives = 154/381 (40%), Gaps = 72/381 (18%)
Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ---C 294
GS + ++ C G + DN DEC + D +C+ T C LQ C
Sbjct: 436 GSTKDLIETCCAAGQQWAIDN-----DECLEIPESGTEDNVCR-TAQRHCCVSYLQEKSC 489
Query: 295 KSGFIQDALGNCI--DINECLSISAPCPIGHTC-----INTEGSYTCQKNVPNCGRGYHL 347
+G + G + N+ IS C + EG +C+ N PN G Y
Sbjct: 490 MAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ-SCESN-PNLG--YPC 545
Query: 348 NE------EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-V 400
N EG + V E P EP R + + R G + + + D
Sbjct: 546 NHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQ 605
Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE-------------------- 440
+EC PG LC H C NT+GSY C+C GF L DGR+C
Sbjct: 606 DECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665
Query: 441 -------------DINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
N C + PC Q C+ V GS C C GY + DGV+CED DEC
Sbjct: 666 SQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM-ADGVSCEDQDECL 724
Query: 487 LPTGGHICSYR--CINIPGSFQC----SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
+ G H CS R C+N GSF C + GY L + R C DI+ECVT +H CS E
Sbjct: 725 M--GAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAH-RKCVDINECVTDLHTCSRGE 781
Query: 541 TCFNIQGGFRCL-AFECPENY 560
C N G F C A C Y
Sbjct: 782 HCVNTLGSFHCYKALTCEPGY 802
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 269 bits (687), Expect = 6e-72
Identities = 154/427 (36%), Positives = 208/427 (48%), Gaps = 68/427 (15%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C G PC C + CSC G + +DG +C+D++EC G H+C G+ C NT+
Sbjct: 5109 DECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTI 5168
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECE--SGIHNCLPDFICQNTLGSFRCRPKLQC 294
GS+RC CG+G+ T D SC+DI+EC+ S H C N +GSF C C
Sbjct: 5169 GSYRCV--VRCGSGFRRTSDGLSCQDINECQESSPCHQ-----RCFNAIGSFHC----GC 5217
Query: 295 KSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
+ G+ Q C+D+NEC C C NT G Y C + C G E GT C
Sbjct: 5218 EPGY-QLKGRKCMDVNECR--QNVCRPDQHCKNTRGGYKC---IDLCPNGMTKAENGT-C 5270
Query: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
+D+DEC C C N+ GS+RC C GY G+ R C+D+NEC++ P + C H+
Sbjct: 5271 IDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVP-KPCAHQ 5329
Query: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDI-------------NECSSSPCS---------Q 452
C NT GS+ C C G L DG+SC + N SP +
Sbjct: 5330 CSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYR 5389
Query: 453 ECANVYGSYQCY-----------------CRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
+ +++Y SY Y C G S+ TC DIDEC C
Sbjct: 5390 QYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEG---SEASHDTCVDIDEC---ENTDACQ 5443
Query: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
+ C N GS+QC CP GY+L NG+ CQDIDEC+ +C N CFN++G ++C+
Sbjct: 5444 HECKNTFGSYQCICP-PGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502
Query: 556 CPENYRR 562
CP NY+R
Sbjct: 5503 CPPNYQR 5509
Score = 177 bits (448), Expect = 3e-44
Identities = 108/276 (39%), Positives = 141/276 (51%), Gaps = 35/276 (12%)
Query: 293 QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
QC SGF D++G C D +EC +A P H+C N G+Y C +C +G + +G
Sbjct: 5091 QCPSGFTLDSVGPFCADEDEC---AAGNPCSHSCHNAMGTYYC-----SCPKGLTIAADG 5142
Query: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF----DGISRMCVDVNECQRYP 407
C D+DECA C G C N+ GS+RC + G F DG+S C D+NECQ
Sbjct: 5143 RTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLS--CQDINECQE-- 5198
Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-- 463
C +C N +GS+ C C G++L GR C D+NEC + C Q C N G Y+C
Sbjct: 5199 SSPCHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCID 5256
Query: 464 YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521
C G ++ + TC DIDEC G H C Y C N GS++C CP GYR GR
Sbjct: 5257 LCPNG--MTKAENGTCIDIDEC--KDGTHQCRYNQICENTRGSYRCVCP-RGYRSQGVGR 5311
Query: 522 NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
C DI+EC C+ C N G F+C+ CP
Sbjct: 5312 PCMDINECEQVPKPCA--HQCSNTPGSFKCI---CP 5342
Score = 167 bits (422), Expect = 3e-41
Identities = 97/231 (41%), Positives = 120/231 (51%), Gaps = 27/231 (11%)
Query: 341 CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
C G+ L+ G C D DECA PC H C N+ G++ C C G R C D+
Sbjct: 5092 CPSGFTLDSVGPFCADEDECA-AGNPC--SHSCHNAMGTYYCSCPKGLTIAADGRTCQDI 5148
Query: 401 NECQRYPGR---LCGHKCENTLGSYLC--SCSVGFRLSVDGRSCEDINEC-SSSPCSQEC 454
+EC GR G C+NT+GSY C C GFR + DG SC+DINEC SSPC Q C
Sbjct: 5149 DECAL--GRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRC 5206
Query: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC--SYRCINIPGSFQC--SCP 510
N GS+ C C GYQL G C D++EC ++C C N G ++C CP
Sbjct: 5207 FNAIGSFHCGCEPGYQLK---GRKCMDVNECR----QNVCRPDQHCKNTRGGYKCIDLCP 5259
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
+G A NG C DIDEC G H C N+ C N +G +RC+ CP YR
Sbjct: 5260 -NGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCV---CPRGYR 5305
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 256 bits (655), Expect = 3e-68
Identities = 151/377 (40%), Positives = 203/377 (53%), Gaps = 36/377 (9%)
Query: 186 CKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR 244
C Q +C +T +C C G+ +G +C DV+EC+ C G C+NTVG+FRC+
Sbjct: 927 CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVCGEGH-CVNTVGAFRCE- 983
Query: 245 DSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
C +GY +T+ C+DIDEC + + PD C N+ GS++C P C GF + G
Sbjct: 984 --YCDSGYRMTQRGRCEDIDECLN--PSTCPDEQCVNSPGSYQCVP---CTEGF-RGWNG 1035
Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
C+D++ECL + C G C N EGSY C +C +GY + C D+DEC
Sbjct: 1036 QCLDVDECLEPNV-CANG-DCSNLEGSYMC-----SCHKGYTRTPDHKHCRDIDEC-QQG 1087
Query: 365 EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYL 423
C G +C N+ GSFRC C GY C D++ECQ LC H +C NT GS+
Sbjct: 1088 NLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH--RHLCAHGQCRNTEGSFQ 1144
Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCE 480
C C G+R S G CEDINEC S C + +C N GSY C C G+QL D TC+
Sbjct: 1145 CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD--DNKTCQ 1202
Query: 481 DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
DI+EC P +C + C+N GSF C C G+ ++ +GR C+DIDECV C
Sbjct: 1203 DINECEHP---GLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNT-VCDS 1257
Query: 539 NETCFNIQGGFRCLAFE 555
+ C N G FRCL ++
Sbjct: 1258 HGFCDNTAGSFRCLCYQ 1274
Score = 216 bits (550), Expect = 4e-56
Identities = 136/352 (38%), Positives = 183/352 (51%), Gaps = 37/352 (10%)
Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCL 274
++NEC C G CIN + C C GY +E C DIDEC H C
Sbjct: 874 EINECTVNPDICGAGH-CINLPVRYTC----ICYEGYRFSEQQRKCVDIDECTQVQHLCS 928
Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYT 333
C+NT GSF C C +GF+ G NCID++ECL C GH C+NT G++
Sbjct: 929 QGR-CENTEGSFLCI----CPAGFMASEEGTNCIDVDECLRPDV-CGEGH-CVNTVGAFR 981
Query: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGYYFDG 392
C+ C GY + + G RC D+DEC P+ C +CVNSPGS++C C G F G
Sbjct: 982 CEY----CDSGYRMTQRG-RCEDIDECLNPST-C-PDEQCVNSPGSYQCVPCTEG--FRG 1032
Query: 393 ISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C 450
+ C+DV+EC P C N GSY+CSC G+ + D + C DI+EC
Sbjct: 1033 WNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 1091
Query: 451 SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSC 509
+ +C N GS++C C +GYQLS CEDIDEC H+C++ +C N GSFQC C
Sbjct: 1092 NGQCKNTEGSFRCTCGQGYQLSAAKD-QCEDIDEC---QHRHLCAHGQCRNTEGSFQCVC 1147
Query: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
GYR + G +C+DI+EC+ C + C N G + C CP+ ++
Sbjct: 1148 -DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDC---TCPDGFQ 1194
Score = 168 bits (425), Expect = 1e-41
Identities = 173/630 (27%), Positives = 239/630 (37%), Gaps = 133/630 (21%)
Query: 27 VDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CAT 80
++ V C +G+R + Q+ C + EC VQ C + E C
Sbjct: 891 INLPVRYTCICYEGYRFSEQQRKC-----VDIDECTQVQHLCSQGRCENTEGSFLCICPA 945
Query: 81 GISLANEQ------DRCATPH--GDNASLEATFVKRCCHCCLLGRAAQA----------Q 122
G + E D C P G+ + RC +C R Q
Sbjct: 946 GFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN 1005
Query: 123 GQSCEYSLMVG----YQC---GQVFRAC---------CVKSQETGDLDVGGLQET----- 161
+C V YQC + FR C++ + D L+ +
Sbjct: 1006 PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC 1065
Query: 162 DKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
K + + D C+ G C QC++T C+C GYQL + CED++EC
Sbjct: 1066 HKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDEC 1125
Query: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFIC 279
H C G+ C NT GSF+C C GY + + C+DI+EC C C
Sbjct: 1126 -QHRHLCAHGQ-CRNTEGSFQCV----CDQGYRASGLGDHCEDINECLEDKSVCQRGD-C 1178
Query: 280 QNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP 339
NT GS+ C C GF D C DINEC P G C+NTEGS+ C
Sbjct: 1179 INTAGSYDCT----CPDGFQLDDNKTCQDINECEHPGLCGPQGE-CLNTEGSFHCV---- 1229
Query: 340 NCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
C +G+ ++ +G C D+DEC C C N+ GSFRC C G+ + CVD
Sbjct: 1230 -CQQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 1287
Query: 400 VNECQRYPGRLCGHK-CENTLGSYLCSCS----------------VGFRLSVD-GRSCED 441
VNEC+ G +CG CEN GS+LC C+ L VD + E+
Sbjct: 1288 VNECELLSG-VCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346
Query: 442 INEC-----SSSPC---------SQECANVYGS--------YQC---------------- 463
EC +S C QEC G+ + C
Sbjct: 1347 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1406
Query: 464 -YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGR 521
+ G S+ G +D DEC L G IC C+N ++C C Y P
Sbjct: 1407 GFVPAGESSSEAGGENYKDADECLL-FGQEICKNGFCLNTRPGYECYCKQGTY-YDPVKL 1464
Query: 522 NCQDIDECVTGIHNCSINETCFNIQGGFRC 551
C D+DEC + I+ C N +G + C
Sbjct: 1465 QCFDMDECQD--PSSCIDGQCVNTEGSYNC 1492
Score = 149 bits (377), Expect = 5e-36
Identities = 88/255 (34%), Positives = 124/255 (48%), Gaps = 50/255 (19%)
Query: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
T+ +++EC + CG GH C+N P + C C GY F R CVD++EC +
Sbjct: 870 TQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 928
Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SSSPCSQ-ECANVYGSYQC-YCRRG 468
+CENT GS+LC C GF S +G +C D++EC C + C N G+++C YC G
Sbjct: 929 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSG 988
Query: 469 YQLSDVDGVTCEDIDECALPT-----------GGHIC-----SYR--------------- 497
Y+++ CEDIDEC P+ G + C +R
Sbjct: 989 YRMTQRG--RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP 1046
Query: 498 -------CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
C N+ GS+ CSC GY P+ ++C+DIDEC G N +N C N +G FR
Sbjct: 1047 NVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFR 1103
Query: 551 CLAFECPENYRRSAA 565
C C + Y+ SAA
Sbjct: 1104 C---TCGQGYQLSAA 1115
Score = 117 bits (292), Expect = 4e-26
Identities = 162/640 (25%), Positives = 235/640 (36%), Gaps = 138/640 (21%)
Query: 27 VDADVLLEA-CCADG---HRMATHQKDCSLPYAT--ESKECRMVQE-----QCCHSQLEE 75
+D D LE CA+G + ++ C Y + K CR + E C + Q +
Sbjct: 1038 LDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKN 1097
Query: 76 LH------CATGISLANEQDRCAT----------PHGDNASLEATFVKRCCHCCLLGRAA 119
C G L+ +D+C HG + E +F +C C G A
Sbjct: 1098 TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSF--QCV--CDQGYRA 1153
Query: 120 QAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDV--GGLQETDKIIEVEEEQEDPYLN 177
G CE R C+ + + D G + +K + E E P L
Sbjct: 1154 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL- 1212
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
C GP + +C +T C C G+ + +DG +CED++EC+ + C C NT
Sbjct: 1213 --C---GP-QGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSHGFCDNTA 1265
Query: 238 GSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRC-------- 288
GSFRC C G++ +D C D++ECE C F C+N GSF C
Sbjct: 1266 GSFRCL----CYQGFQAPQDGQGCVDVNECELLSGVCGEAF-CENVEGSFLCVCADENQE 1320
Query: 289 ---------------------RPKLQCKSGF--IQDA------LGNCIDINECLSISA-- 317
+PK + K + + DA L + EC S
Sbjct: 1321 YSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG 1380
Query: 318 --------PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG-TRCVDVDECAPPAEPCG 368
PCP+ T TE C K G +E G D DEC +
Sbjct: 1381 WGDNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEIC 1437
Query: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
K C+N+ + C CK G Y+D + C D++ECQ P +C NT GSY C C+
Sbjct: 1438 KNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTH 1496
Query: 429 GFRLSVDGRSC-------EDINE------------CSSSPCSQECANVYGSY-QCYCRRG 468
L + C E I E CS+ +Y +C C G
Sbjct: 1497 PMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1556
Query: 469 YQLSDVDGVTC-----EDIDE----CALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAP 518
+ G+ C +D D+ C +P G Y R + S Q + + Y +
Sbjct: 1557 ----EAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1612
Query: 519 NGRNCQD---IDECVTGIHNCSINETCFNIQGGFRCLAFE 555
N + +EC GI N N C +Q G+ C F+
Sbjct: 1613 RFLNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFD 1650
Score = 93.2 bits (230), Expect = 6e-19
Identities = 114/462 (24%), Positives = 165/462 (35%), Gaps = 103/462 (22%)
Query: 178 DRCRGGGPCKQQ--CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES-CI 234
D C C C +T C C+ G+Q DG C DVNEC S C GE+ C
Sbjct: 1247 DECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC--GEAFCE 1304
Query: 235 NTVGSFRC-----QRDSSCGTGYELTEDNSCKDID------ECESGIHNCLPDFICQNTL 283
N GSF C ++ S TG + ++ D+D E + +N +C N L
Sbjct: 1305 NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1364
Query: 284 GSFRCRPKLQCKSG---------FIQDALG---------------------------NCI 307
+ + C SG F LG N
Sbjct: 1365 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1424
Query: 308 DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
D +ECL C+NT Y C C +G + + +C D+DEC P+ C
Sbjct: 1425 DADECLLFGQEICKNGFCLNTRPGYECY-----CKQGTYYDPVKLQCFDMDECQDPSS-C 1478
Query: 368 GKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------DVNECQRYPGRLCGHKCENTLG 420
G +CVN+ GS+ C C D + C+ + E Y LC E+
Sbjct: 1479 IDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQD-LCW---EHLSD 1533
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCS-----------QEC-ANVYGSYQCYCRRG 468
Y+CS + + + C E C+ Q C V G Q Y R
Sbjct: 1534 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1593
Query: 469 --------------YQLSDVDGVTCEDI--DECALPTGGHICSYRCINIPGSFQCSCPSS 512
Y + D + E++ +EC + G + RC+ + + C C
Sbjct: 1594 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCE--NGRCVRVQEGYTCDC-FD 1650
Query: 513 GYRLAPNGRNCQDIDECVTGIHNCSI--NETCFNIQGGFRCL 552
GY L C D++EC + S+ N C N G ++CL
Sbjct: 1651 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1692
Score = 66.2 bits (160), Expect = 7e-11
Identities = 80/293 (27%), Positives = 107/293 (36%), Gaps = 63/293 (21%)
Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
C +T C C G + C D++EC S SC G+ C+NT GS+ C
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1499
Query: 243 --QRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTL-GSFRCRPKLQCKSG 297
+ C E E D+ D C + + +++C L G + C G
Sbjct: 1500 LDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD---EYVCSRPLVGKQTTYTECCCLYG 1556
Query: 298 FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
+A G +C A CP+ Y N+P GR + VD
Sbjct: 1557 ---EAWGM-----QC----ALCPL-----KDSDDYAQLCNIPVTGRRQPYGRDAL--VDF 1597
Query: 358 DECAPP-------------------AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGI 393
E P AE CG + RCV + C+C GY+ D
Sbjct: 1598 SEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTA 1657
Query: 394 SRMCVDVNECQRYPGR--LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
CVDVNEC R LC + KC NT GSY C C G+ S C +N
Sbjct: 1658 KMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 60.5 bits (145), Expect = 4e-09
Identities = 133/557 (23%), Positives = 182/557 (32%), Gaps = 173/557 (31%)
Query: 49 DCSLP---YATESKECRMVQE----QCCHSQLEELH--------CATGISLANEQDRC-- 91
DC+ P ++K C+ + E C Q E L+ C G S++ + C
Sbjct: 1186 DCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCED 1245
Query: 92 ---------ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSC----EYSLMVGYQCGQ 138
HG + +F RC C G A GQ C E L+ G CG+
Sbjct: 1246 IDECVNNTVCDSHGFCDNTAGSF--RCL--CYQGFQAPQDGQGCVDVNECELLSGV-CGE 1300
Query: 139 VFR---------ACCVKSQE----TG--------DLDVGGLQETDKIIEVEEEQEDPYLN 177
F C ++QE TG DLDV Q ++ E D L
Sbjct: 1301 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1360
Query: 178 DRCRGGGPCKQQCRDT-----GD-------------EVVCSCFVGYQLLSDGVSC----- 214
D KQ+C T GD E C G + G S
Sbjct: 1361 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1420
Query: 215 ---EDVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
+D +EC+ G C+ G C+NT + C GT Y+ + C D+DEC+
Sbjct: 1421 ENYKDADECLLFGQEICKNG-FCLNTRPGYECYCKQ--GTYYDPVK-LQCFDMDECQDP- 1475
Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA---------------------------- 302
+C+ D C NT GS+ C C + DA
Sbjct: 1476 SSCI-DGQCVNTEGSYNCF----CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEH 1530
Query: 303 -----------LGNCIDINECLSI--------SAPCPIGHTCINTEGSYTCQKNVPNCGR 343
+G EC + A CP+ Y N+P GR
Sbjct: 1531 LSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL-----KDSDDYAQLCNIPVTGR 1585
Query: 344 GYHLNEEGTRCVDVDE-CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNE 402
+ VD E P A+P R +NS + E C +N
Sbjct: 1586 RQPYGRDAL--VDFSEQYTPEADPYFIQDRFLNSFEELQAE------------ECGILNG 1631
Query: 403 CQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-----SPCSQ-ECAN 456
C+ +C Y C C G+ L +C D+NEC S C +C N
Sbjct: 1632 CEN-------GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684
Query: 457 VYGSYQCYCRRGYQLSD 473
GSY+C C GY SD
Sbjct: 1685 TDGSYKCLCLPGYVPSD 1701
Score = 50.1 bits (118), Expect = 6e-06
Identities = 37/109 (33%), Positives = 45/109 (41%), Gaps = 13/109 (11%)
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
SY + C GY T C D++EC C G C+N+ GS+RC CK G+
Sbjct: 602 SYHGYNQMMECLPGYK-RVNNTFCQDINECQLQGV-CPNGE-CLNTMGSYRCTCKIGFGP 658
Query: 391 DGISRMCV--------DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
D CV + C R GR C H L LC CSVG
Sbjct: 659 DPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 707
Score = 43.5 bits (101), Expect = 5e-04
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 23/94 (24%)
Query: 231 ESCINTVGSF-------RCQRDSS---------CGTGYELTEDNSCKDIDECESGIHNCL 274
E C TVG+ +C + S C GY+ + C+DI+EC+ +
Sbjct: 579 EDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVC 636
Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCI 307
P+ C NT+GS+RC CK GF D +C+
Sbjct: 637 PNGECLNTMGSYRC----TCKIGFGPDPTFSSCV 666
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANVY 458
N+CQ+ P + H + C G++ V+ C+DINEC C EC N
Sbjct: 592 NKCQKCPKKPSYHGYNQMM-----ECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTM 645
Query: 459 GSYQCYCRRGY 469
GSY+C C+ G+
Sbjct: 646 GSYRCTCKIGF 656
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
EC GY + C D+NECQ G +C NT+GSY C+C +GF SC
Sbjct: 611 ECLPGYKRVN-NTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665
Score = 34.3 bits (77), Expect = 0.31
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNC 523
C GY+ V+ C+DI+EC L G + C+N GS++C+C G+ P +C
Sbjct: 612 CLPGYKR--VNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTC-KIGFGPDPTFSSC 665
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 256 bits (655), Expect = 3e-68
Identities = 151/377 (40%), Positives = 203/377 (53%), Gaps = 36/377 (9%)
Query: 186 CKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR 244
C Q +C +T +C C G+ +G +C DV+EC+ C G C+NTVG+FRC+
Sbjct: 601 CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVCGEGH-CVNTVGAFRCE- 657
Query: 245 DSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
C +GY +T+ C+DIDEC + + PD C N+ GS++C P C GF + G
Sbjct: 658 --YCDSGYRMTQRGRCEDIDECLN--PSTCPDEQCVNSPGSYQCVP---CTEGF-RGWNG 709
Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
C+D++ECL + C G C N EGSY C +C +GY + C D+DEC
Sbjct: 710 QCLDVDECLEPNV-CANG-DCSNLEGSYMC-----SCHKGYTRTPDHKHCRDIDEC-QQG 761
Query: 365 EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYL 423
C G +C N+ GSFRC C GY C D++ECQ LC H +C NT GS+
Sbjct: 762 NLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH--RHLCAHGQCRNTEGSFQ 818
Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCE 480
C C G+R S G CEDINEC S C + +C N GSY C C G+QL D TC+
Sbjct: 819 CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD--DNKTCQ 876
Query: 481 DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
DI+EC P +C + C+N GSF C C G+ ++ +GR C+DIDECV C
Sbjct: 877 DINECEHP---GLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNT-VCDS 931
Query: 539 NETCFNIQGGFRCLAFE 555
+ C N G FRCL ++
Sbjct: 932 HGFCDNTAGSFRCLCYQ 948
Score = 216 bits (550), Expect = 4e-56
Identities = 136/352 (38%), Positives = 183/352 (51%), Gaps = 37/352 (10%)
Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCL 274
++NEC C G CIN + C C GY +E C DIDEC H C
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTC----ICYEGYRFSEQQRKCVDIDECTQVQHLCS 602
Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYT 333
C+NT GSF C C +GF+ G NCID++ECL C GH C+NT G++
Sbjct: 603 QGR-CENTEGSFLCI----CPAGFMASEEGTNCIDVDECLRPDV-CGEGH-CVNTVGAFR 655
Query: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGYYFDG 392
C+ C GY + + G RC D+DEC P+ C +CVNSPGS++C C G F G
Sbjct: 656 CEY----CDSGYRMTQRG-RCEDIDECLNPST-C-PDEQCVNSPGSYQCVPCTEG--FRG 706
Query: 393 ISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C 450
+ C+DV+EC P C N GSY+CSC G+ + D + C DI+EC
Sbjct: 707 WNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 765
Query: 451 SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSC 509
+ +C N GS++C C +GYQLS CEDIDEC H+C++ +C N GSFQC C
Sbjct: 766 NGQCKNTEGSFRCTCGQGYQLSAAKD-QCEDIDEC---QHRHLCAHGQCRNTEGSFQCVC 821
Query: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
GYR + G +C+DI+EC+ C + C N G + C CP+ ++
Sbjct: 822 -DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDC---TCPDGFQ 868
Score = 168 bits (425), Expect = 1e-41
Identities = 173/630 (27%), Positives = 239/630 (37%), Gaps = 133/630 (21%)
Query: 27 VDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CAT 80
++ V C +G+R + Q+ C + EC VQ C + E C
Sbjct: 565 INLPVRYTCICYEGYRFSEQQRKC-----VDIDECTQVQHLCSQGRCENTEGSFLCICPA 619
Query: 81 GISLANEQ------DRCATPH--GDNASLEATFVKRCCHCCLLGRAAQA----------Q 122
G + E D C P G+ + RC +C R Q
Sbjct: 620 GFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN 679
Query: 123 GQSCEYSLMVG----YQC---GQVFRAC---------CVKSQETGDLDVGGLQET----- 161
+C V YQC + FR C++ + D L+ +
Sbjct: 680 PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC 739
Query: 162 DKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
K + + D C+ G C QC++T C+C GYQL + CED++EC
Sbjct: 740 HKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDEC 799
Query: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFIC 279
H C G+ C NT GSF+C C GY + + C+DI+EC C C
Sbjct: 800 -QHRHLCAHGQ-CRNTEGSFQCV----CDQGYRASGLGDHCEDINECLEDKSVCQRGD-C 852
Query: 280 QNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP 339
NT GS+ C C GF D C DINEC P G C+NTEGS+ C
Sbjct: 853 INTAGSYDCT----CPDGFQLDDNKTCQDINECEHPGLCGPQGE-CLNTEGSFHCV---- 903
Query: 340 NCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
C +G+ ++ +G C D+DEC C C N+ GSFRC C G+ + CVD
Sbjct: 904 -CQQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 961
Query: 400 VNECQRYPGRLCGHK-CENTLGSYLCSCS----------------VGFRLSVD-GRSCED 441
VNEC+ G +CG CEN GS+LC C+ L VD + E+
Sbjct: 962 VNECELLSG-VCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020
Query: 442 INEC-----SSSPC---------SQECANVYGS--------YQC---------------- 463
EC +S C QEC G+ + C
Sbjct: 1021 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1080
Query: 464 -YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGR 521
+ G S+ G +D DEC L G IC C+N ++C C Y P
Sbjct: 1081 GFVPAGESSSEAGGENYKDADECLL-FGQEICKNGFCLNTRPGYECYCKQGTY-YDPVKL 1138
Query: 522 NCQDIDECVTGIHNCSINETCFNIQGGFRC 551
C D+DEC + I+ C N +G + C
Sbjct: 1139 QCFDMDECQD--PSSCIDGQCVNTEGSYNC 1166
Score = 149 bits (377), Expect = 5e-36
Identities = 88/255 (34%), Positives = 124/255 (48%), Gaps = 50/255 (19%)
Query: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
T+ +++EC + CG GH C+N P + C C GY F R CVD++EC +
Sbjct: 544 TQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 602
Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SSSPCSQ-ECANVYGSYQC-YCRRG 468
+CENT GS+LC C GF S +G +C D++EC C + C N G+++C YC G
Sbjct: 603 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSG 662
Query: 469 YQLSDVDGVTCEDIDECALPT-----------GGHIC-----SYR--------------- 497
Y+++ CEDIDEC P+ G + C +R
Sbjct: 663 YRMTQRG--RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP 720
Query: 498 -------CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
C N+ GS+ CSC GY P+ ++C+DIDEC G N +N C N +G FR
Sbjct: 721 NVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFR 777
Query: 551 CLAFECPENYRRSAA 565
C C + Y+ SAA
Sbjct: 778 C---TCGQGYQLSAA 789
Score = 117 bits (292), Expect = 4e-26
Identities = 162/640 (25%), Positives = 235/640 (36%), Gaps = 138/640 (21%)
Query: 27 VDADVLLEA-CCADG---HRMATHQKDCSLPYAT--ESKECRMVQE-----QCCHSQLEE 75
+D D LE CA+G + ++ C Y + K CR + E C + Q +
Sbjct: 712 LDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKN 771
Query: 76 LH------CATGISLANEQDRCAT----------PHGDNASLEATFVKRCCHCCLLGRAA 119
C G L+ +D+C HG + E +F +C C G A
Sbjct: 772 TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSF--QCV--CDQGYRA 827
Query: 120 QAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDV--GGLQETDKIIEVEEEQEDPYLN 177
G CE R C+ + + D G + +K + E E P L
Sbjct: 828 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL- 886
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
C GP + +C +T C C G+ + +DG +CED++EC+ + C C NT
Sbjct: 887 --C---GP-QGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSHGFCDNTA 939
Query: 238 GSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRC-------- 288
GSFRC C G++ +D C D++ECE C F C+N GSF C
Sbjct: 940 GSFRCL----CYQGFQAPQDGQGCVDVNECELLSGVCGEAF-CENVEGSFLCVCADENQE 994
Query: 289 ---------------------RPKLQCKSGF--IQDA------LGNCIDINECLSISA-- 317
+PK + K + + DA L + EC S
Sbjct: 995 YSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG 1054
Query: 318 --------PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG-TRCVDVDECAPPAEPCG 368
PCP+ T TE C K G +E G D DEC +
Sbjct: 1055 WGDNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEIC 1111
Query: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
K C+N+ + C CK G Y+D + C D++ECQ P +C NT GSY C C+
Sbjct: 1112 KNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTH 1170
Query: 429 GFRLSVDGRSC-------EDINE------------CSSSPCSQECANVYGSY-QCYCRRG 468
L + C E I E CS+ +Y +C C G
Sbjct: 1171 PMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1230
Query: 469 YQLSDVDGVTC-----EDIDE----CALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAP 518
+ G+ C +D D+ C +P G Y R + S Q + + Y +
Sbjct: 1231 ----EAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1286
Query: 519 NGRNCQD---IDECVTGIHNCSINETCFNIQGGFRCLAFE 555
N + +EC GI N N C +Q G+ C F+
Sbjct: 1287 RFLNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFD 1324
Score = 93.2 bits (230), Expect = 6e-19
Identities = 114/462 (24%), Positives = 165/462 (35%), Gaps = 103/462 (22%)
Query: 178 DRCRGGGPCKQQ--CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES-CI 234
D C C C +T C C+ G+Q DG C DVNEC S C GE+ C
Sbjct: 921 DECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC--GEAFCE 978
Query: 235 NTVGSFRC-----QRDSSCGTGYELTEDNSCKDID------ECESGIHNCLPDFICQNTL 283
N GSF C ++ S TG + ++ D+D E + +N +C N L
Sbjct: 979 NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1038
Query: 284 GSFRCRPKLQCKSG---------FIQDALG---------------------------NCI 307
+ + C SG F LG N
Sbjct: 1039 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1098
Query: 308 DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
D +ECL C+NT Y C C +G + + +C D+DEC P+ C
Sbjct: 1099 DADECLLFGQEICKNGFCLNTRPGYECY-----CKQGTYYDPVKLQCFDMDECQDPSS-C 1152
Query: 368 GKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------DVNECQRYPGRLCGHKCENTLG 420
G +CVN+ GS+ C C D + C+ + E Y LC E+
Sbjct: 1153 IDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQD-LCW---EHLSD 1207
Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCS-----------QEC-ANVYGSYQCYCRRG 468
Y+CS + + + C E C+ Q C V G Q Y R
Sbjct: 1208 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1267
Query: 469 --------------YQLSDVDGVTCEDI--DECALPTGGHICSYRCINIPGSFQCSCPSS 512
Y + D + E++ +EC + G + RC+ + + C C
Sbjct: 1268 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCE--NGRCVRVQEGYTCDC-FD 1324
Query: 513 GYRLAPNGRNCQDIDECVTGIHNCSI--NETCFNIQGGFRCL 552
GY L C D++EC + S+ N C N G ++CL
Sbjct: 1325 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366
Score = 66.2 bits (160), Expect = 7e-11
Identities = 80/293 (27%), Positives = 107/293 (36%), Gaps = 63/293 (21%)
Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
C +T C C G + C D++EC S SC G+ C+NT GS+ C
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1173
Query: 243 --QRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTL-GSFRCRPKLQCKSG 297
+ C E E D+ D C + + +++C L G + C G
Sbjct: 1174 LDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD---EYVCSRPLVGKQTTYTECCCLYG 1230
Query: 298 FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
+A G +C A CP+ Y N+P GR + VD
Sbjct: 1231 ---EAWGM-----QC----ALCPL-----KDSDDYAQLCNIPVTGRRQPYGRDAL--VDF 1271
Query: 358 DECAPP-------------------AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGI 393
E P AE CG + RCV + C+C GY+ D
Sbjct: 1272 SEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTA 1331
Query: 394 SRMCVDVNECQRYPGR--LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
CVDVNEC R LC + KC NT GSY C C G+ S C +N
Sbjct: 1332 KMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 60.5 bits (145), Expect = 4e-09
Identities = 133/557 (23%), Positives = 182/557 (32%), Gaps = 173/557 (31%)
Query: 49 DCSLP---YATESKECRMVQE----QCCHSQLEELH--------CATGISLANEQDRC-- 91
DC+ P ++K C+ + E C Q E L+ C G S++ + C
Sbjct: 860 DCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCED 919
Query: 92 ---------ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSC----EYSLMVGYQCGQ 138
HG + +F RC C G A GQ C E L+ G CG+
Sbjct: 920 IDECVNNTVCDSHGFCDNTAGSF--RCL--CYQGFQAPQDGQGCVDVNECELLSGV-CGE 974
Query: 139 VFR---------ACCVKSQE----TG--------DLDVGGLQETDKIIEVEEEQEDPYLN 177
F C ++QE TG DLDV Q ++ E D L
Sbjct: 975 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1034
Query: 178 DRCRGGGPCKQQCRDT-----GD-------------EVVCSCFVGYQLLSDGVSC----- 214
D KQ+C T GD E C G + G S
Sbjct: 1035 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1094
Query: 215 ---EDVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
+D +EC+ G C+ G C+NT + C GT Y+ + C D+DEC+
Sbjct: 1095 ENYKDADECLLFGQEICKNG-FCLNTRPGYECYCKQ--GTYYDPVK-LQCFDMDECQDP- 1149
Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA---------------------------- 302
+C+ D C NT GS+ C C + DA
Sbjct: 1150 SSCI-DGQCVNTEGSYNCF----CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEH 1204
Query: 303 -----------LGNCIDINECLSI--------SAPCPIGHTCINTEGSYTCQKNVPNCGR 343
+G EC + A CP+ Y N+P GR
Sbjct: 1205 LSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL-----KDSDDYAQLCNIPVTGR 1259
Query: 344 GYHLNEEGTRCVDVDE-CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNE 402
+ VD E P A+P R +NS + E C +N
Sbjct: 1260 RQPYGRDAL--VDFSEQYTPEADPYFIQDRFLNSFEELQAE------------ECGILNG 1305
Query: 403 CQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-----SPCSQ-ECAN 456
C+ +C Y C C G+ L +C D+NEC S C +C N
Sbjct: 1306 CEN-------GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358
Query: 457 VYGSYQCYCRRGYQLSD 473
GSY+C C GY SD
Sbjct: 1359 TDGSYKCLCLPGYVPSD 1375
Score = 50.1 bits (118), Expect = 6e-06
Identities = 37/109 (33%), Positives = 45/109 (41%), Gaps = 13/109 (11%)
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
SY + C GY T C D++EC C G C+N+ GS+RC CK G+
Sbjct: 276 SYHGYNQMMECLPGYK-RVNNTFCQDINECQLQGV-CPNGE-CLNTMGSYRCTCKIGFGP 332
Query: 391 DGISRMCV--------DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
D CV + C R GR C H L LC CSVG
Sbjct: 333 DPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 381
Score = 43.5 bits (101), Expect = 5e-04
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 23/94 (24%)
Query: 231 ESCINTVGSF-------RCQRDSS---------CGTGYELTEDNSCKDIDECESGIHNCL 274
E C TVG+ +C + S C GY+ + C+DI+EC+ +
Sbjct: 253 EDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVC 310
Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCI 307
P+ C NT+GS+RC CK GF D +C+
Sbjct: 311 PNGECLNTMGSYRC----TCKIGFGPDPTFSSCV 340
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANVY 458
N+CQ+ P + H + C G++ V+ C+DINEC C EC N
Sbjct: 266 NKCQKCPKKPSYHGYNQMM-----ECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTM 319
Query: 459 GSYQCYCRRGY 469
GSY+C C+ G+
Sbjct: 320 GSYRCTCKIGF 330
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
EC GY + C D+NECQ G +C NT+GSY C+C +GF SC
Sbjct: 285 ECLPGYKRVN-NTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339
Score = 34.3 bits (77), Expect = 0.31
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNC 523
C GY+ V+ C+DI+EC L G + C+N GS++C+C G+ P +C
Sbjct: 286 CLPGYKR--VNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTC-KIGFGPDPTFSSC 339
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 251 bits (641), Expect = 1e-66
Identities = 156/403 (38%), Positives = 208/403 (51%), Gaps = 51/403 (12%)
Query: 178 DRCR-GGGPCKQ-QCRDTGDEVVCSCFVGYQ----LLSDGVSCEDVNECITGSHSCRLGE 231
D CR C Q C +T C CF GY+ L+ + C DV+EC CR G
Sbjct: 1030 DECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN---CMDVDECARDPLLCR-GG 1085
Query: 232 SCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
+C NT GS++CQ C G+ELT + +C+DIDEC C P C N +G+F+C
Sbjct: 1086 TCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCVNVIGAFQC-- 1138
Query: 291 KLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLN 348
C +GF D G C+DINEC + C + CINTEGSY C +CG+GY L
Sbjct: 1139 --SCHAGFQSTPDRQG-CVDINECRVQNGGCDVH--CINTEGSYRC-----SCGQGYSLM 1188
Query: 349 EEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408
+G C DVDEC C +GH C N PG RC C G+ R CVDV+EC P
Sbjct: 1189 PDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP- 1246
Query: 409 RLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQC 463
+C H CENT GS++C C +G+ + C D++EC + C N+ GS+ C
Sbjct: 1247 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
Query: 464 YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521
C G+ DG C D+DEC + H CS R C+N+PGS++C+C A +G
Sbjct: 1307 RCLPGWV---GDGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTCRQG---FAGDGF 1358
Query: 522 NCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYR 561
C+D DEC + C N C N GG+RC + F+ E++R
Sbjct: 1359 FCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHR 1400
Score = 216 bits (549), Expect = 6e-56
Identities = 163/494 (32%), Positives = 216/494 (43%), Gaps = 93/494 (18%)
Query: 113 CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162
C G + G +C + VG+ CGQ F C E G L T
Sbjct: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164
Query: 163 KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222
+ +++E +P L C +C +T +C+C GY L DG C DV+EC
Sbjct: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213
Query: 223 GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276
G C G C N +G+F C G+G T+DN C D C +G
Sbjct: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266
Query: 277 FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316
C NT GSFRC C GF L C DI + C S+S
Sbjct: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
Query: 317 APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
A C G G+ +K P+ G GY EG DVDEC A C
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375
Query: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
G C+NS GSFRC C+ GY D + C+D++EC + P + C C+NT GS+LCSC
Sbjct: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433
Query: 429 GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
G+ L DGR+C+D++EC+S C C N G++ C C G+ C D DEC+
Sbjct: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490
Query: 487 LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546
G C N PGSF+C C G+ L +G C+D++EC G H C C N
Sbjct: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546
Query: 547 GGFRCLAFECPENY 560
GG+RC CP+ +
Sbjct: 2547 GGYRC---SCPQGF 2557
Score = 214 bits (546), Expect = 1e-55
Identities = 136/379 (35%), Positives = 186/379 (49%), Gaps = 34/379 (8%)
Query: 179 RCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVG 238
R + GG C C +T CSC GY L+ DG +C DV+EC C G C N G
Sbjct: 1160 RVQNGG-CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG 1217
Query: 239 SFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
RC C G+ T D +C D+DEC+ H CL C+NT GSF C C+ G
Sbjct: 1218 GHRCL----CYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCH----CQLG 1268
Query: 298 F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356
+ ++ C D++EC C +C+N GS++C+ C G+ +G C D
Sbjct: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGWV--GDGFECHD 1321
Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE 416
+DEC C C+N PGS+RC C+ G+ DG C D +EC +C
Sbjct: 1322 LDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDECAENVDLCDNGQCL 1379
Query: 417 NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCS-QECANVYGSYQCYCRRGYQLSDV 474
N G Y C C +GF + D R+C+D++EC+ + C+ C N+ G ++C C GY+L D
Sbjct: 1380 NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL-DR 1438
Query: 475 DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534
G C DI+ECA P + + CIN PGS+ CSCP + L P+G C D T
Sbjct: 1439 GGGNCTDINECADPV--NCINGVCINTPGSYLCSCPQD-FELNPSGVGCVD-----TRAG 1490
Query: 535 NCSINETCFNIQGGFRCLA 553
NC + ET G C A
Sbjct: 1491 NCFL-ETHDRGDSGISCSA 1508
Score = 213 bits (543), Expect = 3e-55
Identities = 141/380 (37%), Positives = 182/380 (47%), Gaps = 51/380 (13%)
Query: 181 RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
RG GP + C G C G ++G DV+EC +H C GE CIN++GS
Sbjct: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385
Query: 240 FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
FRC C GY T D +C D+DEC C F+C+NT GSF C C
Sbjct: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433
Query: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G++ + G C D++EC S C C+NT G++TC+ C G+ + + C
Sbjct: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484
Query: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
D DEC+ PCG C N+PGSFRCEC G+ C DVNEC P R C H C
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472
+N LG Y CSC GF C D NEC+ SP C S C N G ++C C G+
Sbjct: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
Query: 473 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-----------SGYRLAPNGR 521
G C+++DECA G CSY C N PG F C CP SG +P +
Sbjct: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
Query: 522 NCQDIDECVT--GIHNCSIN 539
+ D +E ++ + C IN
Sbjct: 2660 DTPDKEELLSSEACYECKIN 2679
Score = 197 bits (500), Expect = 3e-50
Identities = 137/397 (34%), Positives = 186/397 (46%), Gaps = 51/397 (12%)
Query: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234
+C +T C C G L + G C DV +EC +T R+ C I
Sbjct: 884 RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
Query: 235 NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279
V C+ S C G G+ + S KD++EC+ C C
Sbjct: 944 GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002
Query: 280 QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
+NT+GSF C C GF DA NC DI+EC C G TC+NT GS+ C+
Sbjct: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056
Query: 339 PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
P G+ L + C+DVDECA C +G C N+ GS++C+C G+ C
Sbjct: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
Query: 399 DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455
D++EC G LC H +C N +G++ CSC GF+ + D + C DINEC + C C
Sbjct: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
Query: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514
N GSY+C C +GY L DG C D+DEC +C C N+PG +C C G+
Sbjct: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227
Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
P+ R C D+DEC H C ++ C N +G F C
Sbjct: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC 1263
Score = 196 bits (499), Expect = 4e-50
Identities = 154/508 (30%), Positives = 218/508 (42%), Gaps = 87/508 (17%)
Query: 87 EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146
E +C+ P N + CC R + G CE G F+ C
Sbjct: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068
Query: 147 SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206
G V G ++ + +V E E+P + C G C +T C C GY
Sbjct: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116
Query: 207 LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266
L G++C D +EC G H C G +C N +G F C +C G+E +C+DIDEC
Sbjct: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170
Query: 267 ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPI-GHT 324
++ L F C NT GS+ C C +G+ +++ C D++EC C G
Sbjct: 2171 --SLNPLLCAFRCHNTEGSYLC----TCPAGYTLREDGAMCRDVDECADGQQDCHARGME 2224
Query: 325 CINTEGSYTCQKNVPNCGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
C N G++ C C G L G C D +EC + C G RCVN+ GSFRC+
Sbjct: 2225 CKNLIGTFACV-----CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCD 2278
Query: 384 CKTGY-----------------YFDGISRMCVDVN---------ECQRYPGRLCGHKCE- 416
C G+ + + + MC ++ EC GR G +CE
Sbjct: 2279 CDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338
Query: 417 ---NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSD 473
+Y C G + +GR ++ + EC N GS++C+C+ GY D
Sbjct: 2339 CPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGY-TPD 2397
Query: 474 VDGVTCEDIDECA-LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532
TC D+DEC+ +P C++ C N GSF CSCP GY L +GR C+D+DEC +
Sbjct: 2398 ATATTCLDMDECSQVPKP---CTFLCKNTKGSFLCSCP-RGYLLEEDGRTCKDLDECTSR 2453
Query: 533 IHNCSINETCFNIQGGFRCLAFECPENY 560
HNC C N G F C CP +
Sbjct: 2454 QHNCQF--LCVNTVGAFTC---RCPPGF 2476
Score = 187 bits (476), Expect = 2e-47
Identities = 158/491 (32%), Positives = 211/491 (42%), Gaps = 84/491 (17%)
Query: 107 KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163
K CC +G+A ++C + YQ CG +Q G L D+ T K
Sbjct: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718
Query: 164 IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223
++++E E P + C G C + C C G+ S ++CEDV+EC +
Sbjct: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
Query: 224 SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
C+ CIN GS+RC+ C GY+L+ +C +EC I N C +T
Sbjct: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825
Query: 284 GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342
GS+ C C GF A C+DI+EC PC G TC N GSY C C
Sbjct: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873
Query: 343 RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
G+ + G CVD DEC + C GH C+N+ GSF C C+ G+ + CVD N
Sbjct: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
Query: 402 ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458
EC G C+N GS+ C C GF++ D C DI+ECS P C N
Sbjct: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
Query: 459 GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503
GS+QC C G+ LSD +G C D +C++P + RC PG
Sbjct: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048
Query: 504 -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549
C CP G L P G +D++EC C+ N C N G F
Sbjct: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107
Query: 550 RCLAFECPENY 560
RC ECP Y
Sbjct: 2108 RC---ECPFGY 2115
Score = 172 bits (437), Expect = 6e-43
Identities = 130/383 (33%), Positives = 169/383 (44%), Gaps = 62/383 (16%)
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C PC C + C C+ G+Q +C DV+ECI C LG C+NT
Sbjct: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508
Query: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
GSF+C C G+EL+ D +C D +EC + + +C N GSF C CK
Sbjct: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558
Query: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
GF+ G+ C+DI+EC C GH C NTEGS+ CQ C G + +G C
Sbjct: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611
Query: 355 VDV------------DECAPP-------AEPC------GKGHRCVNSP----GSFRCECK 385
VD CA P +E C G G C P F+ C
Sbjct: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCS 671
Query: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
+G GI+ D+NEC P CEN GSY C C++G+ G+ C D++EC
Sbjct: 672 SGL---GITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDEC 728
Query: 446 --SSSPCSQE-CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
+S C C N GSY C C G+ D C+D+DEC S C N+
Sbjct: 729 ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQ-DTEICKDVDEC---LSSPCVSGVCRNLA 784
Query: 503 GSFQCSCPSSGYRLAPNGRNCQD 525
GS+ C C G RL P+G C D
Sbjct: 785 GSYTCKC-GPGSRLDPSGTFCLD 806
Score = 162 bits (410), Expect = 8e-40
Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)
Query: 94 PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150
PHG + E V C H C G + G FR C ++ T
Sbjct: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395
Query: 151 GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210
D + D+ +V + PC C++T +CSC GY L D
Sbjct: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440
Query: 211 GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
G +C+D++EC + H+C+ C+NTVG+F C+ C G+ +C D DEC +
Sbjct: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493
Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329
C C NT GSFRC +C GF + G+ C D+NEC P H C N
Sbjct: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546
Query: 330 GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
G Y C +C +G+ + + +CVD +ECA CG C N+ G FRC C +G+
Sbjct: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600
Query: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446
FD C +V+EC G C + C NT G +LC C G+ + G +
Sbjct: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
Query: 447 SSPCSQECANVYGSYQC 463
+P +E + Y+C
Sbjct: 2660 DTPDKEELLSSEACYEC 2676
Score = 160 bits (405), Expect = 3e-39
Identities = 172/631 (27%), Positives = 242/631 (38%), Gaps = 132/631 (20%)
Query: 3 RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59
+A P+R+ + + ++ GGL L V+ + + C G ++ K+C +
Sbjct: 479 QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533
Query: 60 ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104
EC M C ++ C A G + D C TP +G + E +
Sbjct: 534 ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
Query: 105 FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164
F RC CL G A G+ C + + G + + C +
Sbjct: 594 F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633
Query: 165 IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224
+ E N G PC+ E C G + +DG D+NEC
Sbjct: 634 PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690
Query: 225 HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283
C G C N GS+RC C GYE C D+DEC C + CQN+
Sbjct: 691 EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744
Query: 284 GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
GS+ C C GF QD C D++ECLS +PC G C N GSYTC+ C
Sbjct: 745 GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791
Query: 342 GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383
G G L+ GT C+D + C + C + G+ RCE
Sbjct: 792 GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851
Query: 384 ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
C G+ G++ C DVNEC+ +PG +C NT GS+ C C G L GR C
Sbjct: 852 DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
Query: 440 EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468
D+ +EC C V+G + C RG
Sbjct: 910 VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
Query: 469 YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523
+ D ++ +D++EC + G +C++ C N GSF C+C + G+ L RNC
Sbjct: 970 LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026
Query: 524 QDIDECVTGIHNCSINETCFNIQGGFRCLAF 554
DIDEC C TC N G F C F
Sbjct: 1027 TDIDECRISPDLCG-QGTCVNTPGSFECECF 1056
Score = 159 bits (403), Expect = 5e-39
Identities = 138/451 (30%), Positives = 194/451 (43%), Gaps = 88/451 (19%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C G QC + C C +G+ D +C+DV+EC G+ C G SC N
Sbjct: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
G FRC C GYEL +C DI+EC + NC+ + +C NT GS+ C +
Sbjct: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477
Query: 297 -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330
G + GNC D + +S SA +G T C + G
Sbjct: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
+ T + + G G+ N D+DEC C +G CVN+ GSF+CEC GY+
Sbjct: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596
Query: 391 DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444
+R+C D++EC + G +CG C NTLG+Y C C + G +C D+ +
Sbjct: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
Query: 445 --------------------CS-------SSPCSQECANVYGSYQCYCRR---GYQLSDV 474
CS + PC + YQ C G+ L+D+
Sbjct: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF-LTDI 1714
Query: 475 DGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532
DIDEC +P IC+ CIN GSF+C CP +G+ C+D+DEC +
Sbjct: 1715 HTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGSR 1770
Query: 533 IHNCSINETCFNIQGGFRCLAFECPENYRRS 563
C N C NI G +RC +C Y+ S
Sbjct: 1771 ESPCQQNADCINIPGSYRC---KCTRGYKLS 1798
Score = 150 bits (379), Expect = 3e-36
Identities = 110/335 (32%), Positives = 145/335 (43%), Gaps = 57/335 (17%)
Query: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322
ID C + CL + C T S+RC +C G+ QD G CID++EC S+PC G
Sbjct: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461
Query: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382
C+N G+Y C+ C G+ CVDVDEC C G RCVN+ GSF+C
Sbjct: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514
Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
C G+ + CVD NEC +C C N GS+ C C GF L+ G C D
Sbjct: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572
Query: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487
I+EC + + C N GS++C C G + DG C D CA
Sbjct: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631
Query: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
P G + C FQ C SSG + +GR DI+EC
Sbjct: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687
Query: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565
C+ N C N++G +RC+ C Y A+
Sbjct: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGAS 718
Score = 147 bits (370), Expect = 3e-35
Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)
Query: 94 PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153
P G L + C +GRA G CE + C + F ++
Sbjct: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240
Query: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213
G Q+ D E Q P L C+GG C + C C VG++L +
Sbjct: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286
Query: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265
CED S G C + +R C G EL + +
Sbjct: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
Query: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306
G+ L F LG R P G GN
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
Query: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362
IDI C + C G C+ T SY C+ NV GY + G C+DVDEC
Sbjct: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454
Query: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422
+ PC G CVN PG++ C C G+ + CVDV+EC G +C NT GS+
Sbjct: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
Query: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
C C+ GF LS DG++C D NEC++S + C N GS+ C C+ G+ L+ G C
Sbjct: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571
Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
DIDEC P G + C N GSF+C C G + +GR C D
Sbjct: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613
Score = 135 bits (340), Expect = 1e-31
Identities = 107/357 (29%), Positives = 158/357 (44%), Gaps = 61/357 (17%)
Query: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271
+C+DV+EC C+ G SC+N VGSF C+ C G+ L++ ++ C+D +G
Sbjct: 244 ACQDVDECQAVPGLCQ-GGSCVNMVGSFHCR----CPVGHRLSDSSAACEDY---RAGA- 294
Query: 272 NCLPDFICQNTLGSFRCRPKL-------QCKSGFIQDALGNCIDINECLSISAPCPIGHT 324
C + L RC L QC C D C + P+
Sbjct: 295 -------CFSVLFGGRCAGDLAGHYTRRQC-----------CCDRGRCWAAG---PVPEL 333
Query: 325 CI---NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-----GKGHRCVNS 376
C + E C + +P G+ G + PP P G R + S
Sbjct: 334 CPPRGSNEFQQLCAQRLPLLP-GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
Query: 377 PGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436
G G G + + ++ C+ + +C T SY C C+VG+ V G
Sbjct: 393 LGP-------GNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG 445
Query: 437 RSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
C D++EC+SSPC +C N+ G+Y C C G+Q + C D+DEC + +GG
Sbjct: 446 -ECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPT-RQACVDVDEC-IVSGGLCHL 502
Query: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
RC+N GSFQC C ++G+ L+P+G+NC D +EC T +N C N G F CL
Sbjct: 503 GRCVNTEGSFQCVC-NAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSCL 556
Score = 71.2 bits (173), Expect = 2e-12
Identities = 93/365 (25%), Positives = 127/365 (34%), Gaps = 98/365 (26%)
Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
IC+ G C +P L C G + + G ++ S C G TC S CQ
Sbjct: 85 ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138
Query: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381
K P C RG H G RC+ + CA P E + C G
Sbjct: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195
Query: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407
C+ C+ G+ + + C DV+ECQ P
Sbjct: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461
G G C N +GS+ C C VG RLS +CED C S C+ + A Y
Sbjct: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
Query: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505
QC C RG + + E P G + +C+ R +P GS
Sbjct: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369
Query: 506 QCSCPSSGYRLAPNGRNCQDIDECVTG---IHNCSINETC------FNIQGGFRCLAFEC 556
P RL P+G + + I G I ++N+T N+ RCL
Sbjct: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCL--PT 427
Query: 557 PENYR 561
P +YR
Sbjct: 428 PSSYR 432
Score = 61.6 bits (148), Expect = 2e-09
Identities = 105/423 (24%), Positives = 142/423 (33%), Gaps = 87/423 (20%)
Query: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238
C++ C + +C+C G S GVS C C+ G +CR G SC+ G
Sbjct: 86 CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141
Query: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289
C + D C G N C C G C D+ C +G C+
Sbjct: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197
Query: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
+L +G + C + + PC + C C RG+ N
Sbjct: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240
Query: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
C DVDEC C +G CVN GSF C C G+ S C D +
Sbjct: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298
Query: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455
L G +C L + C C G R G E S+ Q CA
Sbjct: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357
Query: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496
N G R SD G+ +I L IC +
Sbjct: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417
Query: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
RC+ P S++C C + GY G C D+DEC + C + C NI G + C
Sbjct: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472
Query: 552 LAF 554
+
Sbjct: 473 RCY 475
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 250 bits (639), Expect = 2e-66
Identities = 176/580 (30%), Positives = 254/580 (43%), Gaps = 120/580 (20%)
Query: 34 EACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE------ELHCATGISLANE 87
E C G AT + P+ + EC+M+ C H + + C +G +L +E
Sbjct: 1005 EELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSE 1064
Query: 88 QDRCATPHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACC 144
+ C T + C C G+ G E GY+ G + C
Sbjct: 1065 ERNC------------TDIDECRISPDLCGRGQCVNTPG-DFECKCDEGYESGFMMMKNC 1111
Query: 145 VKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVG 204
++++E Q DP L CRGG C +T C C G
Sbjct: 1112 --------------------MDIDECQRDPLL---CRGG-----VCHNTEGSYRCECPPG 1143
Query: 205 YQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC---------------------- 242
+QL + +C D+NEC +H C G C+N +G ++C
Sbjct: 1144 HQLSPNISACIDINECELSAHLCPNGR-CVNLIGKYQCACNPGYHSTPDRLFCVDIDECS 1202
Query: 243 ---------------QRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSF 286
+ SC G+ L D SC DIDECE + C C N G +
Sbjct: 1203 IMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNIC-DGGQCTNIPGEY 1261
Query: 287 RCRPKLQCKSGFI-QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY 345
RC C GF+ + + C+D+NEC ++ + TC NT+GS+ C +C GY
Sbjct: 1262 RC----LCYDGFMASEDMKTCVDVNEC-DLNPNICLSGTCENTKGSFIC-----HCDMGY 1311
Query: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
+ T C D++EC A CGK C N+ GSF+C C G+ DGI C D++EC
Sbjct: 1312 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIK--CTDLDECSN 1369
Query: 406 YPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQ-ECANVYGSY 461
H C+NT+GSY C C G+ + DG +C D++ECS + C +C N G Y
Sbjct: 1370 GTHMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGY 1427
Query: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNG 520
+C C G+ + DG CEDIDEC+LP +IC + C N+PG F+C C GY L +G
Sbjct: 1428 RCECDMGF-VPSADGKACEDIDECSLP---NICVFGTCHNLPGLFRCEC-EIGYELDRSG 1482
Query: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
NC D++EC+ I+ C N G + C +CP ++
Sbjct: 1483 GNCTDVNECLD--PTTCISGNCVNTPGSYIC---DCPPDF 1517
Score = 225 bits (574), Expect = 7e-59
Identities = 140/386 (36%), Positives = 194/386 (50%), Gaps = 41/386 (10%)
Query: 189 QCRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSS 247
QC +T + C C GY+ +C D++EC CR G C NT GS+RC+
Sbjct: 1085 QCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCR-GGVCHNTEGSYRCE---- 1139
Query: 248 CGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALG 304
C G++L+ + ++C DI+ECE H C P+ C N +G ++C C G+ D L
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLC-PNGRCVNLIGKYQCA----CNPGYHSTPDRLF 1194
Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
C+DI+EC ++ C C N+EGSY C +C G+ L + C D+DEC
Sbjct: 1195 -CVDIDECSIMNGGCET--FCTNSEGSYEC-----SCQPGFALMPDQRSCTDIDECEDNP 1246
Query: 365 EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLC 424
C G +C N PG +RC C G+ + CVDVNEC P CENT GS++C
Sbjct: 1247 NICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFIC 1305
Query: 425 SCSVGFRLSVDGRSCEDINEC--SSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCE 480
C +G+ C DINEC + C + C N GS++C C G+ DG+ C
Sbjct: 1306 HCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW---IGDGIKCT 1362
Query: 481 DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
D+DEC+ G H+CS C N GS++C C GY +G C D+DEC ++ C
Sbjct: 1363 DLDECS--NGTHMCSQHADCKNTMGSYRCLC-KEGY--TGDGFTCTDLDECSENLNLCG- 1416
Query: 539 NETCFNIQGGFRCLAFECPENYRRSA 564
N C N GG+RC EC + SA
Sbjct: 1417 NGQCLNAPGGYRC---ECDMGFVPSA 1439
Score = 218 bits (555), Expect = 1e-56
Identities = 180/611 (29%), Positives = 246/611 (40%), Gaps = 116/611 (18%)
Query: 13 PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68
PLL GG+ G C GH+++ + C + EC + C
Sbjct: 1121 PLLCRGGVCHNTEGS-----YRCECPPGHQLSPNISAC-----IDINECELSAHLCPNGR 1170
Query: 69 CHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCC-------HC-CLLGRAAQ 120
C + + + CA + DR D S+ + C C C G A
Sbjct: 1171 CVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALM 1230
Query: 121 AQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVEE 169
+SC ++ G QC + +R C + + ++V E
Sbjct: 1231 PDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASE-------DMKTCVDVNE 1283
Query: 170 EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
+P + C G C +T +C C +GY C D+NEC G+H+C
Sbjct: 1284 CDLNPNI---CLSG-----TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGK 1335
Query: 230 GESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
C NT GSF+C SC G+ + + C D+DEC +G H C C+NT+GS+RC
Sbjct: 1336 HAVCTNTAGSFKC----SCSPGW-IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCL 1390
Query: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
CK G+ D C D++EC C G C+N G Y C+ C G+ +
Sbjct: 1391 ----CKEGYTGDGF-TCTDLDECSENLNLCGNGQ-CLNAPGGYRCE-----CDMGFVPSA 1439
Query: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
+G C D+DEC+ P C G C N PG FRCEC+ GY D C DVNEC P
Sbjct: 1440 DGKACEDIDECSLP-NICVFG-TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLD-PTT 1496
Query: 410 LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN------------ECSSSPCSQECANV 457
C NT GSY+C C F L+ C D + + CS E
Sbjct: 1497 CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVG 1556
Query: 458 YGSYQCYCRRG-----------------YQLSDVDG---------VTCEDIDECALPTGG 491
C C G Y++ G V EDIDEC G
Sbjct: 1557 VSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPG- 1615
Query: 492 HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGF 549
+C +CIN GSFQC CP +GY L + R C D++EC T GI C TC+N G +
Sbjct: 1616 -LCQGGKCINTFGSFQCRCP-TGYYLNEDTRVCDDVNECETPGI--CGPG-TCYNTVGNY 1670
Query: 550 RCLAFECPENY 560
C+ CP +Y
Sbjct: 1671 TCI---CPPDY 1678
Score = 213 bits (542), Expect = 4e-55
Identities = 156/479 (32%), Positives = 219/479 (45%), Gaps = 71/479 (14%)
Query: 59 KECRMVQEQCCHSQLEELHCATGISLANEQD-RCATPHGD------NASLEATFVKRCCH 111
K C + E Q + L C G+ E RC P G +A ++ + H
Sbjct: 1109 KNCMDIDE----CQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAH 1164
Query: 112 CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
C GR G+ YQC AC + G D++ V+ +
Sbjct: 1165 LCPNGRCVNLIGK---------YQC-----AC----------NPGYHSTPDRLFCVDID- 1199
Query: 172 EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
E +N G C+ C ++ CSC G+ L+ D SC D++EC + C G
Sbjct: 1200 ECSIMN------GGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICD-GG 1252
Query: 232 SCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
C N G +RC C G+ +ED +C D++EC+ + CL C+NT GSF C
Sbjct: 1253 QCTNIPGEYRC----LCYDGFMASEDMKTCVDVNECDLNPNICLSG-TCENTKGSFIC-- 1305
Query: 291 KLQCKSGFI-QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
C G+ + C DINEC + C C NT GS+ C +C G+
Sbjct: 1306 --HCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC-----SCSPGW--IG 1356
Query: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
+G +C D+DEC+ C + C N+ GS+RC CK GY DG + C D++EC
Sbjct: 1357 DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFT--CTDLDECSENL-N 1413
Query: 410 LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCR 466
LCG+ +C N G Y C C +GF S DG++CEDI+ECS + C N+ G ++C C
Sbjct: 1414 LCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECE 1473
Query: 467 RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
GY+L D G C D++EC PT S C+N PGS+ C CP + L P C D
Sbjct: 1474 IGYEL-DRSGGNCTDVNECLDPT--TCISGNCVNTPGSYICDCPPD-FELNPTRVGCVD 1528
Score = 208 bits (530), Expect = 9e-54
Identities = 145/408 (35%), Positives = 189/408 (46%), Gaps = 56/408 (13%)
Query: 184 GPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNE--CITG--SHSCRLGESCINTVG 238
G C+ +C +T C C G+ + C D E C T + C++G S N V
Sbjct: 2300 GICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVT 2359
Query: 239 SFRCQRDSSCGTGYE---------LTEDNSCK----------DIDECESGIHNCLPDFIC 279
C D G G + C DIDEC+ IH+ + C
Sbjct: 2360 KSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKV-IHDVCRNGEC 2418
Query: 280 QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
N GS+ C CK+G+ D G +C+D+NEC AP P C NTEGSY C
Sbjct: 2419 VNDRGSYHCI----CKTGYTPDITGTSCVDLNECNQ--APKPCNFICKNTEGSYQC---- 2468
Query: 339 PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
+C +GY L E+G C D+DECA C CVN+ G F C+C G+ S C+
Sbjct: 2469 -SCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTCKCPPGFTQHHTS--CI 2523
Query: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECA 455
D NEC LCG K C+NT GS+ C C GF L G SCED++EC + C C
Sbjct: 2524 DNNECTS-DINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQ 2582
Query: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS-YRCINIPGSFQCSCPSSGY 514
N+ G Y+C C +GY L C D +EC HIC C N GS++C CP+ G+
Sbjct: 2583 NIIGGYRCSCPQGY-LQHYQWNQCVDENECL---SAHICGGASCHNTLGSYKCMCPA-GF 2637
Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
+ CQDI+EC + CS C N +GG+ C CP Y R
Sbjct: 2638 QYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLC---GCPPGYFR 2680
Score = 207 bits (526), Expect = 3e-53
Identities = 135/415 (32%), Positives = 186/415 (44%), Gaps = 58/415 (13%)
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C G PC C++ C+C G++ ++CED+NEC C C+NT
Sbjct: 2168 DECSVGNPCGNGTCKNVIGGFECTCEEGFEP-GPMMTCEDINECAQNPLLCAF--RCVNT 2224
Query: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFI-CQNTLGSFRCRPKLQC 294
GS+ C+ C GY L ED CKD DECE G H+C + C+N +G++ C C
Sbjct: 2225 YGSYECK----CPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI----C 2276
Query: 295 KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
G+ + G C+D NEC + C G C+NT GSYTC+ C G+ +
Sbjct: 2277 GPGYQRRPDGEGCVDENECQTKPGICENGR-CLNTRGSYTCE-----CNDGFTASPNQDE 2330
Query: 354 CVDVDE--CAPPA--EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC------------ 397
C+D E C C G N C C G + +C
Sbjct: 2331 CLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLC 2390
Query: 398 ----------VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
D++EC+ +C N GSY C C G+ + G SC D+NEC+
Sbjct: 2391 PHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQ 2450
Query: 448 SP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
+P C+ C N GSYQC C +GY L + DG +C+D+DECA T H C + C+N G F
Sbjct: 2451 APKPCNFICKNTEGSYQCSCPKGYILQE-DGRSCKDLDECA--TKQHNCQFLCVNTIGGF 2507
Query: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
C CP + +C D +EC + I+ C C N G F C EC +
Sbjct: 2508 TCKCPPG---FTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTC---ECQRGF 2556
Score = 198 bits (503), Expect = 1e-50
Identities = 127/380 (33%), Positives = 175/380 (46%), Gaps = 50/380 (13%)
Query: 166 EVEEEQEDPYLNDRC-----RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNE 219
++ +P C RG GP + C G C G +++G D++E
Sbjct: 2349 QIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGA---DIDE 2405
Query: 220 CITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPD 276
C CR GE C+N GS+ C C TGY T D SC D++EC C +
Sbjct: 2406 CKVIHDVCRNGE-CVNDRGSYHC----ICKTGY--TPDITGTSCVDLNECNQAPKPC--N 2456
Query: 277 FICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
FIC+NT GS++C C G+I G +C D++EC + C C+NT G +TC+
Sbjct: 2457 FICKNTEGSYQC----SCPKGYILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTCK 2510
Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISR 395
C G+ + T C+D +EC CG C N+PGSF CEC+ G+ D
Sbjct: 2511 -----CPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGS 2563
Query: 396 MCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQE 453
C DV+EC+ C H C+N +G Y CSC G+ C D NEC S+
Sbjct: 2564 SCEDVDECE--GNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS 2621
Query: 454 CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSG 513
C N GSY+C C G+Q G C+DI+EC + CSY C N G + C CP
Sbjct: 2622 CHNTLGSYKCMCPAGFQYEQFSG-GCQDINECG--SAQAPCSYGCSNTEGGYLCGCPPGY 2678
Query: 514 YRLAPNGRNCQDIDECVTGI 533
+R+ CV+G+
Sbjct: 2679 FRIGQG--------HCVSGM 2690
Score = 196 bits (497), Expect = 6e-50
Identities = 174/601 (28%), Positives = 243/601 (40%), Gaps = 120/601 (19%)
Query: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CATGISLANEQ-- 88
C +G+ +A + C + EC + +C + L C G SL NE+
Sbjct: 1958 CNEGYEVAPDGRTC-----VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCE 2012
Query: 89 --DRCATPH-----GDNASLEATFVKRCCHCCLLGRAAQAQGQSCE-------YSLMVGY 134
D C G ++ E +F +C C G + + G+ C+ Y+ G
Sbjct: 2013 DIDECVEEPEICALGTCSNTEGSF--KCL--CPEGFSLSSSGRRCQDLRMSYCYAKFEGG 2068
Query: 135 QCGQVFR--------ACCVKSQETGDLDVGGLQETDKIIE---------VEEEQEDPYLN 177
+C C +K + GD E D+ + +
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDM 2128
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C+ CK QC +T C C GY L G C D +EC G+ C G +C N
Sbjct: 2129 DECKEPDVCKHGQCINTDGSYRCECPFGYILA--GNECVDTDECSVGN-PCGNG-TCKNV 2184
Query: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
+G F C +C G+E +C+DI+EC C F C NT GS+ C+ C
Sbjct: 2185 IGGFEC----TCEEGFEPGPMMTCEDINECAQNPLLCA--FRCVNTYGSYECK----CPV 2234
Query: 297 GFI-QDALGNCIDINECLSISAPCPIGHT-CINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
G++ ++ C D +EC C C N G+Y C CG GY +G C
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI-----CGPGYQRRPDGEGC 2289
Query: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY-----------------YFDGISRMC 397
VD +EC C G RC+N+ GS+ CEC G+ + + + MC
Sbjct: 2290 VDENECQTKPGICENG-RCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMC 2348
Query: 398 ---------VDVNECQRYPGRLCGHKCE------NTLGSYLCSCSVGFRLSVDGRSCEDI 442
V +EC GR G CE LC GF + DI
Sbjct: 2349 QIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG-----ADI 2403
Query: 443 NECS--SSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI 499
+EC C EC N GSY C C+ GY D+ G +C D++EC C++ C
Sbjct: 2404 DECKVIHDVCRNGECVNDRGSYHCICKTGYT-PDITGTSCVDLNECN--QAPKPCNFICK 2460
Query: 500 NIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPEN 559
N GS+QCSCP GY L +GR+C+D+DEC T HNC C N GGF C +CP
Sbjct: 2461 NTEGSYQCSCPK-GYILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTC---KCPPG 2514
Query: 560 Y 560
+
Sbjct: 2515 F 2515
Score = 194 bits (492), Expect = 2e-49
Identities = 151/487 (31%), Positives = 213/487 (43%), Gaps = 79/487 (16%)
Query: 107 KRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIE 166
K CC +GRA + C F C + +D+ T ++
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPST------DEFATLCGSQRPGFVIDI----YTGLPVD 1766
Query: 167 VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
++E +E P + C G C + C C VG+ + CED++EC G
Sbjct: 1767 IDECREIPGV---CENG-----VCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGP-V 1817
Query: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
C+ CINT GS+RC C GY T C D +EC+ I N C +T+GSF
Sbjct: 1818 CQRNAECINTAGSYRCD----CKPGYRFTSTGQCNDRNECQE-IPNICSHGQCIDTVGSF 1872
Query: 287 RCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY 345
C C +GF D C+DINEC + C G TC NT GS+ C+ C G+
Sbjct: 1873 YCL----CHTGFKTNDDQTMCLDINECERDA--CGNG-TCRNTIGSFNCR-----CNHGF 1920
Query: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
L+ C+DVDECA + +C+N+ GSF+C+C GY R CVD+NEC
Sbjct: 1921 ILSHNND-CIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLL 1979
Query: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS-QECANVYGSYQ 462
P + C+N GSY C C G+ S+ CEDI+EC P C+ C+N GS++
Sbjct: 1980 EPRKCAPGTCQNLDGSYRCICPPGY--SLQNEKCEDIDECVEEPEICALGTCSNTEGSFK 2037
Query: 463 CYCRRGYQLSDVDGVTCEDI-----------DECALP-TGGHICSYRCINIPG------- 503
C C G+ LS G C+D+ +C+ P + H C + G
Sbjct: 2038 CLCPEGFSLSS-SGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPC 2096
Query: 504 ---------SFQCSCP-SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
+F+ CP SG + P+ + D+DEC + + C N G +RC
Sbjct: 2097 ELCPTEPDEAFRQICPYGSGIIVGPDD-SAVDMDECKE--PDVCKHGQCINTDGSYRC-- 2151
Query: 554 FECPENY 560
ECP Y
Sbjct: 2152 -ECPFGY 2157
Score = 179 bits (455), Expect = 5e-45
Identities = 159/530 (30%), Positives = 217/530 (40%), Gaps = 141/530 (26%)
Query: 127 EYSLMVGYQC--GQVFR---ACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCR 181
+Y +V Y C G+ +C + + LD+ G + I+V+E +++P C
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRG-----ECIDVDECEKNP-----CA 500
Query: 182 GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241
GG +C + C C GYQ C D++EC+ C G CINT GSF
Sbjct: 501 GG-----ECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR-CINTDGSFH 554
Query: 242 CQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
C C G+ +T D +C+D+DEC I N + +C N GSF+C CK GF
Sbjct: 555 C----VCNAGFHVTRDGKNCEDMDEC--SIRNMCLNGMCINEDGSFKC----ICKPGFQL 604
Query: 301 DALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV-- 357
+ G C DINEC C G C+NT+GSY C+ C G + +G CVD
Sbjct: 605 ASDGRYCKDINEC-ETPGICMNGR-CVNTDGSYRCE-----CFPGLAVGLDGRVCVDTHM 657
Query: 358 -----------------------DEC---------APPAEPC--------------GKG- 370
EC P +PC G G
Sbjct: 658 RSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGM 717
Query: 371 -------HRCVNSP------------GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
+ C P G+++C C +GY D + CVD+NEC LC
Sbjct: 718 TSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECV-LNSLLC 776
Query: 412 GH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC-SQECANVYGSYQCYCRRGY 469
+ +C NT GS++C+C GF D ++CEDI+EC SSPC + C N GS+ C C
Sbjct: 777 DNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSES 836
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRC-INIPG-SFQCSCPSS--------------- 512
L + E I T + RC INI G + + C SS
Sbjct: 837 TLDPTKTICIETIKGTCWQT---VIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVD 893
Query: 513 -----GYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
GY G C+DIDEC C N C N +G F+C +CP
Sbjct: 894 PICGKGYSRI-KGTQCEDIDECEVFPGVCK-NGLCVNTRGSFKC---QCP 938
Score = 173 bits (439), Expect = 3e-43
Identities = 140/461 (30%), Positives = 187/461 (40%), Gaps = 118/461 (25%)
Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
C + C C GY++ S G +C D+NEC+ S C G+ C NT GSF C +C
Sbjct: 739 CENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ-CRNTPGSFVC----TCP 793
Query: 250 TGYELTED-NSCKDIDECESG------IHNCLPDFICQ---------------------- 280
G+ D +C+DIDECES N FIC+
Sbjct: 794 KGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTC 853
Query: 281 -NTLGSFRCRPKLQ----------------------------CKSGFIQDALGNCIDINE 311
T+ RC + C G+ + C DI+E
Sbjct: 854 WQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDE 913
Query: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV-----------DEC 360
C C G C+NT GS+ CQ C G L+ G C+D+ +EC
Sbjct: 914 CEVFPGVCKNG-LCVNTRGSFKCQ-----CPSGMTLDATGRICLDIRLETCFLRYEDEEC 967
Query: 361 APPAEPCGKGHRCVNSPGSF----RCE-------------CKTGYYF-----DGISRMCV 398
P + C S G+ CE C G F
Sbjct: 968 TLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFK 1027
Query: 399 DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQ-EC 454
D+NEC+ P LC H KC NT+GS+ C C GF L + R+C DI+EC SP C + +C
Sbjct: 1028 DINECKMIPS-LCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQC 1086
Query: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC----ALPTGGHICSYRCINIPGSFQCSCP 510
N G ++C C GY+ + C DIDEC L GG C N GS++C CP
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGG-----VCHNTEGSYRCECP 1141
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
G++L+PN C DI+EC H C N C N+ G ++C
Sbjct: 1142 -PGHQLSPNISACIDINECELSAHLCP-NGRCVNLIGKYQC 1180
Score = 160 bits (406), Expect = 2e-39
Identities = 145/501 (28%), Positives = 190/501 (37%), Gaps = 142/501 (28%)
Query: 178 DRCRGGGP-CKQQ--CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCI 234
D C G C Q C++T C C GY DG +C D++EC + C G+ C+
Sbjct: 1365 DECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSENLNLCGNGQ-CL 1421
Query: 235 NTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293
N G +RC+ C G+ + D +C+DIDEC + N C N G FRC +
Sbjct: 1422 NAPGGYRCE----CDMGFVPSADGKACEDIDECS--LPNICVFGTCHNLPGLFRC----E 1471
Query: 294 CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352
C+ G+ D G NC D+NECL + C G+ C+NT GSY C +C + LN
Sbjct: 1472 CEIGYELDRSGGNCTDVNECLDPTT-CISGN-CVNTPGSYIC-----DCPPDFELNPTRV 1524
Query: 353 RCVDV--DECAPPAEPCGKGH--RCVNSPG----SFRCECKTGYYFDGISRMCV------ 398
CVD C P G C N G C C G + MC
Sbjct: 1525 GCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSE 1584
Query: 399 ---------------------DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
D++ECQ PG G KC NT GS+ C C G+ L+ D R
Sbjct: 1585 YKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTR 1644
Query: 438 SCEDINECSS-SPCSQ-ECANVYGSYQCYC----------------RRG--YQLSDVDGV 477
C+D+NEC + C C N G+Y C C RR Y+ D
Sbjct: 1645 VCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQ 1704
Query: 478 TCE------------------------DIDECALP---------------------TGGH 492
TC+ ++C +P TG
Sbjct: 1705 TCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLP 1764
Query: 493 ICSYRCINIPG------------SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
+ C IPG SF+C CP G+ C+DIDEC G C N
Sbjct: 1765 VDIDECREIPGVCENGVCINMVGSFRCECP-VGFFYNDKLLVCEDIDECQNG-PVCQRNA 1822
Query: 541 TCFNIQGGFRCLAFECPENYR 561
C N G +RC +C YR
Sbjct: 1823 ECINTAGSYRC---DCKPGYR 1840
Score = 136 bits (343), Expect = 4e-32
Identities = 124/427 (29%), Positives = 176/427 (41%), Gaps = 94/427 (22%)
Query: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL---- 254
C C +GY+L G +C DVNEC+ + +C G +C+NT GS+ C C +EL
Sbjct: 1470 CECEIGYELDRSGGNCTDVNECLDPT-TCISG-NCVNTPGSYICD----CPPDFELNPTR 1523
Query: 255 -----TEDNSCK-DI--------DECESGIHNCLPDFICQNTLGSFRCRPKLQCKS---- 296
T +C DI C + I + C +LG P C +
Sbjct: 1524 VGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTS 1583
Query: 297 ----------GFIQDALGNCI-DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY 345
GF + + + DI+EC + C G CINT GS+ C+ C GY
Sbjct: 1584 EYKILCPGGEGFRPNPITVILEDIDECQELPGLCQ-GGKCINTFGSFQCR-----CPTGY 1637
Query: 346 HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
+LNE+ C DV+EC P CG G C N+ G++ C C Y C+D+
Sbjct: 1638 YLNEDTRVCDDVNECETPGI-CGPG-TCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLC 1695
Query: 406 Y-----PGRLCGHKCENTLGSYLCSCSV------------------------------GF 430
Y + C + + +C CS GF
Sbjct: 1696 YRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGF 1755
Query: 431 RLSVDGRSCEDINECSSSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL 487
+ + DI+EC P E C N+ GS++C C G+ +D + CEDIDEC
Sbjct: 1756 VIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYND-KLLVCEDIDEC-- 1812
Query: 488 PTGGHIC--SYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545
G +C + CIN GS++C C GYR G+ C D +EC + CS + C +
Sbjct: 1813 -QNGPVCQRNAECINTAGSYRCDC-KPGYRFTSTGQ-CNDRNECQEIPNICSHGQ-CIDT 1868
Query: 546 QGGFRCL 552
G F CL
Sbjct: 1869 VGSFYCL 1875
Score = 103 bits (258), Expect = 3e-22
Identities = 85/302 (28%), Positives = 112/302 (37%), Gaps = 64/302 (21%)
Query: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCI 234
+ N RC GG C C C GY G C G C G C+
Sbjct: 118 HCNIRCMNGGSCSDDH--------CLCQKGYI----GTHC--------GQPVCESG--CL 155
Query: 235 NTVGSFRCQRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTLGSFRCRPKL 292
N RC + C Y T +D C + I N + CQ L C L
Sbjct: 156 N---GGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQM----CQGQLSGIVCTKTL 208
Query: 293 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352
C + + A G+ PC + C C RG+ N
Sbjct: 209 CCAT--VGRAWGH------------PCEM------------CPAQPHPCRRGFIPNIRTG 242
Query: 353 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412
C DVDEC C +G C+N+ GSF C+C G+ + +S+ C D++EC PG G
Sbjct: 243 ACQDVDECQAIPGLC-QGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEG 301
Query: 413 HKCENTLGSYLCSCSVGFRLSVDGRSCEDI------NECSSSPCSQECANVYGSYQCYCR 466
+C NT+ SY C C GF S DG C D+ ++ CS + QC C
Sbjct: 302 GECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCD 361
Query: 467 RG 468
G
Sbjct: 362 AG 363
Score = 89.4 bits (220), Expect = 8e-18
Identities = 86/284 (30%), Positives = 125/284 (44%), Gaps = 51/284 (17%)
Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
IC+++ G C RP + C SG I + G+ I C + C G +C ++ CQ
Sbjct: 84 ICRHSCGDGFCSRPNMCTCPSGQIAPSCGSR-SIQHC---NIRCMNGGSC--SDDHCLCQ 137
Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC----KTGYYFD 391
K G + E G C++ C P +RC + G +C +TG F
Sbjct: 138 KGYIGTHCGQPVCESG--CLNGGRCVAP-------NRCACTYGFTGPQCERDYRTGPCFT 188
Query: 392 GIS-RMC--------VDVNECQRYPGRLCGHKCENTLGSYLCS-----CSVGFRLSVDGR 437
IS +MC C GR GH CE +C C GF ++
Sbjct: 189 VISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE------MCPAQPHPCRRGFIPNIRTG 242
Query: 438 SCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
+C+D++EC + P C C N GS++C C G++L++V CEDIDEC+ G IC
Sbjct: 243 ACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEV-SQKCEDIDECSTIPG--IC 299
Query: 495 -SYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI--DECVTGIHN 535
C N S+ C CP G+ +P+G C D+ C T + N
Sbjct: 300 EGGECTNTVSSYFCKCP-PGFYTSPDGTRCIDVRPGYCYTALTN 342
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 239 bits (611), Expect = 4e-63
Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T C C +G+Q + G CEDV+EC +H G+ C+N
Sbjct: 687 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 744
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
+ GSF+C+ +C +G+ L C D+DEC SG C P C NT GSFRC P +
Sbjct: 745 SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800
Query: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
SG G C D+NECL P G C+NT+GS+ C C GY G
Sbjct: 801 APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 850
Query: 354 CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
C+DVDEC+ + C G C N+ GSF C C G+ C+DV+EC+ LCG
Sbjct: 851 CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 908
Query: 413 HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
+CEN+ GSY C C G+ +G +C+D++EC C +Q C N GSY+C
Sbjct: 909 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 967
Query: 465 CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
C GYQ + G C+D+DEC + G H C N+PGSFQC C GY A +GR+
Sbjct: 968 CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1021
Query: 523 CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
C D++EC T C C N++G F C+ PE +
Sbjct: 1022 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1058
Score = 216 bits (550), Expect = 4e-56
Identities = 157/470 (33%), Positives = 203/470 (43%), Gaps = 107/470 (22%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T +C C GYQ G SC+DV+EC C G +C N
Sbjct: 564 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 622
Query: 236 TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
GSFRC Q CG G S
Sbjct: 623 LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 682
Query: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
C+D+DEC C C+NT GSF+C C GF + G+ C D++EC + A
Sbjct: 683 CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 736
Query: 319 CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
CP G C+N+ GS+ C+ C G+HL+ RC DVDEC+ A PCG C N+ G
Sbjct: 737 CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 789
Query: 379 SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
SFRC C GY G C DVNEC +C NT GS+ C+C+ G+R G
Sbjct: 790 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 849
Query: 438 SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLS-------DVDGV----------- 477
SC D++ECS Q C N GS++C C G++ DVD
Sbjct: 850 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 909
Query: 478 -------------------------TCEDIDECALPTGGHIC-SYRCINIPGSFQCS-CP 510
TC+D+DEC G IC + RC N PGS++C+
Sbjct: 910 RCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-EYGPEICGAQRCENTPGSYRCTPAC 968
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
GY+ P G CQD+DEC C + C N+ G F+CL C + Y
Sbjct: 969 DPGYQPTPGG-GCQDVDECRNRSF-CGAHAVCQNLPGSFQCL---CDQGY 1013
Score = 212 bits (539), Expect = 8e-55
Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)
Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
GP + R +G C+C G++L G C DV+EC C G C N+ GSFRC
Sbjct: 490 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 545
Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
CG G+ C D+DEC H P C+NT GSF C C +G+
Sbjct: 546 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 594
Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
G +C D++EC C G C N GS+ C C G+ G+ C DV
Sbjct: 595 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 644
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DECA PCG G RC N+ GSF C C G+ G C DV+EC R P +CEN
Sbjct: 645 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 703
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
T GS+ C C +GF+ + G CED++EC + QEC N GS+QC C G+ L
Sbjct: 704 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 760
Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
C D+DEC A P G H C N GSF+CSC + GYR AP+GR C D++EC
Sbjct: 761 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 815
Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
+ G C + C N G F C C YR
Sbjct: 816 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 843
Score = 187 bits (474), Expect = 3e-47
Identities = 102/248 (41%), Positives = 138/248 (55%), Gaps = 27/248 (10%)
Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
CI+ YTC C G+ L+ +GTRC+DVDEC PC G RC NSPGSFRC C
Sbjct: 494 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 547
Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
G+ + C+DV+EC R P +CENT GS+LC C G++ + G SC+D++E
Sbjct: 548 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 607
Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
C+ SP C + C N+ GS++C C G++ G C ED+DECA P G R
Sbjct: 608 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 658
Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
C N GSF C+CP +G+R G CQD+DEC C+ C N +G F+C+ CP
Sbjct: 659 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 713
Query: 558 ENYRRSAA 565
++ + A
Sbjct: 714 MGFQPNTA 721
Score = 135 bits (341), Expect = 8e-32
Identities = 76/207 (36%), Positives = 103/207 (49%), Gaps = 18/207 (8%)
Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
C + CG G RC++ P + C C +G+ C+DV+EC+R P +CEN+
Sbjct: 482 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 540
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
GS+ C C GFR C D++EC PC C N GS+ C C GYQ + G
Sbjct: 541 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 599
Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
+C+D+DEC G +C C N+PGSF+C CP +G+R G C +D+DEC
Sbjct: 600 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 652
Query: 535 NCSINETCFNIQGGFRCLAFECPENYR 561
C C N G F C CP +R
Sbjct: 653 PCGPGR-CDNTAGSFHC---ACPAGFR 675
Score = 112 bits (279), Expect = 1e-24
Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)
Query: 178 DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
D CR GP Q+C ++ C C GY +G +C+DV+EC +
Sbjct: 896 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 954
Query: 233 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
C NT GS+RC +C GY+ T C+D+DEC + C +CQN GSF+C
Sbjct: 955 CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1008
Query: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
C G+ G +C+D+NEC ++ C C N EGS+ C PN + +
Sbjct: 1009 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1062
Query: 352 TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
RCV A PP P GS R EC YF
Sbjct: 1063 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1118
Query: 391 D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
D I V EC G G C E LC G+ S
Sbjct: 1119 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1178
Query: 434 VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
D D++EC C S C N Y CYC GY + C D DECA
Sbjct: 1179 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1237
Query: 487 -LPTGGHICSYRCINIPGSFQCSC 509
GG RC+N GS+ C+C
Sbjct: 1238 PACEGG-----RCVNTVGSYHCTC 1256
Score = 70.9 bits (172), Expect = 3e-12
Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)
Query: 308 DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
D++EC L C G C+NT Y+C C GY+ + + C+D DECA EP
Sbjct: 1186 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1238
Query: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
+G RCVN+ GS+ C C+ DG R CV NE Q L C H
Sbjct: 1239 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1297
Query: 415 CENTLGSYL-CSCSVGFRLSVDGRSC 439
+ +Y C C G +D C
Sbjct: 1298 RLDRQATYTECCCLYGEAWGMDCALC 1323
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 342 GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
GRGY L G + DVDEC + K CVN+ + C C GYY+ C+D
Sbjct: 1171 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1229
Query: 400 VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
+EC G +C NT+GSY C+C L R C
Sbjct: 1230 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1269
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)
Query: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
AE CG RCV P F C C GY D CVD+NEC LC +C
Sbjct: 1467 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1526
Query: 416 ENTLGSYLCSCSVGF 430
NT GS+ C C GF
Sbjct: 1527 LNTDGSFRCICRPGF 1541
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)
Query: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
++ EC I C G C+ +TC+ C GY L+ CVD++EC A A
Sbjct: 1465 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1517
Query: 365 EPCGKGHRCVNSPGSFRCECKTGY 388
P RC+N+ GSFRC C+ G+
Sbjct: 1518 SPLCVNARCLNTDGSFRCICRPGF 1541
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)
Query: 459 GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
GSY Y+ +++ C +D C T G RC+ +P F C C GYRL
Sbjct: 1452 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1500
Query: 519 NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
C DI+EC +N C N G FRC+
Sbjct: 1501 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 398 VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
++ EC G G +C + C C G+RL + +C DINEC ++SP +
Sbjct: 1465 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523
Query: 452 QECANVYGSYQCYCRRGY 469
C N GS++C CR G+
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541
Score = 46.2 bits (108), Expect = 8e-05
Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
E E E+ + D C G +C + C CF GY+L ++C D+NEC +
Sbjct: 1464 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1518
Query: 228 RL--GESCINTVGSFRC 242
L C+NT GSFRC
Sbjct: 1519 PLCVNARCLNTDGSFRC 1535
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
V +C +E G R V++P C TG F+ ++ C DV+EC G C H +C
Sbjct: 254 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 305
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
NT G Y C C GF L SC + + + PC
Sbjct: 306 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 342
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
GSY S + + ++ C ++ C++ C V + C C GY+L D+ + C
Sbjct: 1452 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1505
Query: 480 EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
DI+EC +C + RC+N GSF+C C
Sbjct: 1506 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1537
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)
Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
G+H+C +C LG+ P C +GF + G+C D++EC + C G C
Sbjct: 253 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 306
Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
NT G YTC C G+ L+ + C+ + PC
Sbjct: 307 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 342
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)
Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
G H C+L C +G+ D C TG+E + SC+D+DEC +G C
Sbjct: 253 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 306
Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
NT G + C C GF+ D + +CI + PC
Sbjct: 307 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 342
Score = 43.5 bits (101), Expect = 5e-04
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
+D+DEC+ +C NT + C C +G+ CID +EC C
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1240
Query: 320 PIGHTCINTEGSYTCQKNVP 339
G C+NT GSY C P
Sbjct: 1241 E-GGRCVNTVGSYHCTCEPP 1259
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)
Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
V++CQ LC + N+ + + C GF V+G SCED++EC++ Q ECA
Sbjct: 254 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 306
Query: 456 NVYGSYQCYCRRGYQL 471
N G Y C C G+ L
Sbjct: 307 NTRGGYTCVCPDGFLL 322
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)
Query: 252 YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
YE E C +D C +G C F CR C G+ D C+DIN
Sbjct: 1462 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1509
Query: 311 ECLSISAPCP--IGHTCINTEGSYTC 334
EC A P + C+NT+GS+ C
Sbjct: 1510 ECDEAEAASPLCVNARCLNTDGSFRC 1535
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)
Query: 112 CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
CC +G + G C G + + +++ C + G L G D + + ++
Sbjct: 1140 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1189
Query: 172 EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
+ + C+ G C +T C C GY + + C D +EC +C G
Sbjct: 1190 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1243
Query: 232 SCINTVGSFRC 242
C+NTVGS+ C
Sbjct: 1244 RCVNTVGSYHC 1254
Score = 38.9 bits (89), Expect = 0.013
Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)
Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
S+P ++ G C+ R G S + G+ +++ L G H C +
Sbjct: 206 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 265
Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
S + S CP+ R+ NG +C+D+DEC TG C E C N +GG+ C+ CP
Sbjct: 266 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 317
Query: 558 ENY 560
+ +
Sbjct: 318 DGF 320
Score = 37.0 bits (84), Expect = 0.048
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
C G++ ++ SCEDV+EC TG C+ GE C NT G + C C G+ L S
Sbjct: 277 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 327
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 239 bits (611), Expect = 4e-63
Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T C C +G+Q + G CEDV+EC +H G+ C+N
Sbjct: 717 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 774
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
+ GSF+C+ +C +G+ L C D+DEC SG C P C NT GSFRC P +
Sbjct: 775 SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 830
Query: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
SG G C D+NECL P G C+NT+GS+ C C GY G
Sbjct: 831 APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 880
Query: 354 CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
C+DVDEC+ + C G C N+ GSF C C G+ C+DV+EC+ LCG
Sbjct: 881 CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 938
Query: 413 HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
+CEN+ GSY C C G+ +G +C+D++EC C +Q C N GSY+C
Sbjct: 939 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 997
Query: 465 CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
C GYQ + G C+D+DEC + G H C N+PGSFQC C GY A +GR+
Sbjct: 998 CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1051
Query: 523 CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
C D++EC T C C N++G F C+ PE +
Sbjct: 1052 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1088
Score = 216 bits (550), Expect = 4e-56
Identities = 157/470 (33%), Positives = 203/470 (43%), Gaps = 107/470 (22%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T +C C GYQ G SC+DV+EC C G +C N
Sbjct: 594 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 652
Query: 236 TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
GSFRC Q CG G S
Sbjct: 653 LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 712
Query: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
C+D+DEC C C+NT GSF+C C GF + G+ C D++EC + A
Sbjct: 713 CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 766
Query: 319 CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
CP G C+N+ GS+ C+ C G+HL+ RC DVDEC+ A PCG C N+ G
Sbjct: 767 CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 819
Query: 379 SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
SFRC C GY G C DVNEC +C NT GS+ C+C+ G+R G
Sbjct: 820 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 879
Query: 438 SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLS-------DVDGV----------- 477
SC D++ECS Q C N GS++C C G++ DVD
Sbjct: 880 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 939
Query: 478 -------------------------TCEDIDECALPTGGHIC-SYRCINIPGSFQCS-CP 510
TC+D+DEC G IC + RC N PGS++C+
Sbjct: 940 RCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-EYGPEICGAQRCENTPGSYRCTPAC 998
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
GY+ P G CQD+DEC C + C N+ G F+CL C + Y
Sbjct: 999 DPGYQPTPGG-GCQDVDECRNRSF-CGAHAVCQNLPGSFQCL---CDQGY 1043
Score = 212 bits (539), Expect = 8e-55
Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)
Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
GP + R +G C+C G++L G C DV+EC C G C N+ GSFRC
Sbjct: 520 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 575
Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
CG G+ C D+DEC H P C+NT GSF C C +G+
Sbjct: 576 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 624
Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
G +C D++EC C G C N GS+ C C G+ G+ C DV
Sbjct: 625 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 674
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DECA PCG G RC N+ GSF C C G+ G C DV+EC R P +CEN
Sbjct: 675 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 733
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
T GS+ C C +GF+ + G CED++EC + QEC N GS+QC C G+ L
Sbjct: 734 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 790
Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
C D+DEC A P G H C N GSF+CSC + GYR AP+GR C D++EC
Sbjct: 791 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 845
Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
+ G C + C N G F C C YR
Sbjct: 846 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 873
Score = 187 bits (474), Expect = 3e-47
Identities = 102/248 (41%), Positives = 138/248 (55%), Gaps = 27/248 (10%)
Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
CI+ YTC C G+ L+ +GTRC+DVDEC PC G RC NSPGSFRC C
Sbjct: 524 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 577
Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
G+ + C+DV+EC R P +CENT GS+LC C G++ + G SC+D++E
Sbjct: 578 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 637
Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
C+ SP C + C N+ GS++C C G++ G C ED+DECA P G R
Sbjct: 638 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 688
Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
C N GSF C+CP +G+R G CQD+DEC C+ C N +G F+C+ CP
Sbjct: 689 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 743
Query: 558 ENYRRSAA 565
++ + A
Sbjct: 744 MGFQPNTA 751
Score = 135 bits (341), Expect = 8e-32
Identities = 76/207 (36%), Positives = 103/207 (49%), Gaps = 18/207 (8%)
Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
C + CG G RC++ P + C C +G+ C+DV+EC+R P +CEN+
Sbjct: 512 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 570
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
GS+ C C GFR C D++EC PC C N GS+ C C GYQ + G
Sbjct: 571 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 629
Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
+C+D+DEC G +C C N+PGSF+C CP +G+R G C +D+DEC
Sbjct: 630 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 682
Query: 535 NCSINETCFNIQGGFRCLAFECPENYR 561
C C N G F C CP +R
Sbjct: 683 PCGPGR-CDNTAGSFHC---ACPAGFR 705
Score = 112 bits (279), Expect = 1e-24
Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)
Query: 178 DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
D CR GP Q+C ++ C C GY +G +C+DV+EC +
Sbjct: 926 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 984
Query: 233 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
C NT GS+RC +C GY+ T C+D+DEC + C +CQN GSF+C
Sbjct: 985 CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1038
Query: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
C G+ G +C+D+NEC ++ C C N EGS+ C PN + +
Sbjct: 1039 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1092
Query: 352 TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
RCV A PP P GS R EC YF
Sbjct: 1093 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1148
Query: 391 D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
D I V EC G G C E LC G+ S
Sbjct: 1149 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1208
Query: 434 VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
D D++EC C S C N Y CYC GY + C D DECA
Sbjct: 1209 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1267
Query: 487 -LPTGGHICSYRCINIPGSFQCSC 509
GG RC+N GS+ C+C
Sbjct: 1268 PACEGG-----RCVNTVGSYHCTC 1286
Score = 70.9 bits (172), Expect = 3e-12
Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)
Query: 308 DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
D++EC L C G C+NT Y+C C GY+ + + C+D DECA EP
Sbjct: 1216 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1268
Query: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
+G RCVN+ GS+ C C+ DG R CV NE Q L C H
Sbjct: 1269 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1327
Query: 415 CENTLGSYL-CSCSVGFRLSVDGRSC 439
+ +Y C C G +D C
Sbjct: 1328 RLDRQATYTECCCLYGEAWGMDCALC 1353
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 342 GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
GRGY L G + DVDEC + K CVN+ + C C GYY+ C+D
Sbjct: 1201 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1259
Query: 400 VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
+EC G +C NT+GSY C+C L R C
Sbjct: 1260 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1299
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)
Query: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
AE CG RCV P F C C GY D CVD+NEC LC +C
Sbjct: 1497 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1556
Query: 416 ENTLGSYLCSCSVGF 430
NT GS+ C C GF
Sbjct: 1557 LNTDGSFRCICRPGF 1571
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)
Query: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
++ EC I C G C+ +TC+ C GY L+ CVD++EC A A
Sbjct: 1495 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1547
Query: 365 EPCGKGHRCVNSPGSFRCECKTGY 388
P RC+N+ GSFRC C+ G+
Sbjct: 1548 SPLCVNARCLNTDGSFRCICRPGF 1571
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)
Query: 459 GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
GSY Y+ +++ C +D C T G RC+ +P F C C GYRL
Sbjct: 1482 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1530
Query: 519 NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
C DI+EC +N C N G FRC+
Sbjct: 1531 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 398 VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
++ EC G G +C + C C G+RL + +C DINEC ++SP +
Sbjct: 1495 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553
Query: 452 QECANVYGSYQCYCRRGY 469
C N GS++C CR G+
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571
Score = 46.2 bits (108), Expect = 8e-05
Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
E E E+ + D C G +C + C CF GY+L ++C D+NEC +
Sbjct: 1494 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1548
Query: 228 RL--GESCINTVGSFRC 242
L C+NT GSFRC
Sbjct: 1549 PLCVNARCLNTDGSFRC 1565
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
V +C +E G R V++P C TG F+ ++ C DV+EC G C H +C
Sbjct: 284 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 335
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
NT G Y C C GF L SC + + + PC
Sbjct: 336 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 372
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
GSY S + + ++ C ++ C++ C V + C C GY+L D+ + C
Sbjct: 1482 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1535
Query: 480 EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
DI+EC +C + RC+N GSF+C C
Sbjct: 1536 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1567
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)
Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
G+H+C +C LG+ P C +GF + G+C D++EC + C G C
Sbjct: 283 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 336
Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
NT G YTC C G+ L+ + C+ + PC
Sbjct: 337 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 372
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)
Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
G H C+L C +G+ D C TG+E + SC+D+DEC +G C
Sbjct: 283 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 336
Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
NT G + C C GF+ D + +CI + PC
Sbjct: 337 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 372
Score = 43.5 bits (101), Expect = 5e-04
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
+D+DEC+ +C NT + C C +G+ CID +EC C
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1270
Query: 320 PIGHTCINTEGSYTCQKNVP 339
G C+NT GSY C P
Sbjct: 1271 E-GGRCVNTVGSYHCTCEPP 1289
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)
Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
V++CQ LC + N+ + + C GF V+G SCED++EC++ Q ECA
Sbjct: 284 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 336
Query: 456 NVYGSYQCYCRRGYQL 471
N G Y C C G+ L
Sbjct: 337 NTRGGYTCVCPDGFLL 352
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)
Query: 252 YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
YE E C +D C +G C F CR C G+ D C+DIN
Sbjct: 1492 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1539
Query: 311 ECLSISAPCP--IGHTCINTEGSYTC 334
EC A P + C+NT+GS+ C
Sbjct: 1540 ECDEAEAASPLCVNARCLNTDGSFRC 1565
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)
Query: 112 CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
CC +G + G C G + + +++ C + G L G D + + ++
Sbjct: 1170 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1219
Query: 172 EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
+ + C+ G C +T C C GY + + C D +EC +C G
Sbjct: 1220 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1273
Query: 232 SCINTVGSFRC 242
C+NTVGS+ C
Sbjct: 1274 RCVNTVGSYHC 1284
Score = 38.9 bits (89), Expect = 0.013
Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)
Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
S+P ++ G C+ R G S + G+ +++ L G H C +
Sbjct: 236 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 295
Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
S + S CP+ R+ NG +C+D+DEC TG C E C N +GG+ C+ CP
Sbjct: 296 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 347
Query: 558 ENY 560
+ +
Sbjct: 348 DGF 350
Score = 37.0 bits (84), Expect = 0.048
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
C G++ ++ SCEDV+EC TG C+ GE C NT G + C C G+ L S
Sbjct: 307 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 357
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 239 bits (611), Expect = 4e-63
Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T C C +G+Q + G CEDV+EC +H G+ C+N
Sbjct: 754 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 811
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
+ GSF+C+ +C +G+ L C D+DEC SG C P C NT GSFRC P +
Sbjct: 812 SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 867
Query: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
SG G C D+NECL P G C+NT+GS+ C C GY G
Sbjct: 868 APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 917
Query: 354 CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
C+DVDEC+ + C G C N+ GSF C C G+ C+DV+EC+ LCG
Sbjct: 918 CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 975
Query: 413 HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
+CEN+ GSY C C G+ +G +C+D++EC C +Q C N GSY+C
Sbjct: 976 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 1034
Query: 465 CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
C GYQ + G C+D+DEC + G H C N+PGSFQC C GY A +GR+
Sbjct: 1035 CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1088
Query: 523 CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
C D++EC T C C N++G F C+ PE +
Sbjct: 1089 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1125
Score = 216 bits (550), Expect = 4e-56
Identities = 157/470 (33%), Positives = 203/470 (43%), Gaps = 107/470 (22%)
Query: 178 DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C R PC +C +T +C C GYQ G SC+DV+EC C G +C N
Sbjct: 631 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 689
Query: 236 TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
GSFRC Q CG G S
Sbjct: 690 LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 749
Query: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
C+D+DEC C C+NT GSF+C C GF + G+ C D++EC + A
Sbjct: 750 CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 803
Query: 319 CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
CP G C+N+ GS+ C+ C G+HL+ RC DVDEC+ A PCG C N+ G
Sbjct: 804 CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 856
Query: 379 SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
SFRC C GY G C DVNEC +C NT GS+ C+C+ G+R G
Sbjct: 857 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 916
Query: 438 SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLS-------DVDGV----------- 477
SC D++ECS Q C N GS++C C G++ DVD
Sbjct: 917 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 976
Query: 478 -------------------------TCEDIDECALPTGGHIC-SYRCINIPGSFQCS-CP 510
TC+D+DEC G IC + RC N PGS++C+
Sbjct: 977 RCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-EYGPEICGAQRCENTPGSYRCTPAC 1035
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
GY+ P G CQD+DEC C + C N+ G F+CL C + Y
Sbjct: 1036 DPGYQPTPGG-GCQDVDECRNRSF-CGAHAVCQNLPGSFQCL---CDQGY 1080
Score = 212 bits (539), Expect = 8e-55
Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)
Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
GP + R +G C+C G++L G C DV+EC C G C N+ GSFRC
Sbjct: 557 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 612
Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
CG G+ C D+DEC H P C+NT GSF C C +G+
Sbjct: 613 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 661
Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
G +C D++EC C G C N GS+ C C G+ G+ C DV
Sbjct: 662 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 711
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DECA PCG G RC N+ GSF C C G+ G C DV+EC R P +CEN
Sbjct: 712 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 770
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
T GS+ C C +GF+ + G CED++EC + QEC N GS+QC C G+ L
Sbjct: 771 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 827
Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
C D+DEC A P G H C N GSF+CSC + GYR AP+GR C D++EC
Sbjct: 828 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 882
Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
+ G C + C N G F C C YR
Sbjct: 883 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 910
Score = 187 bits (474), Expect = 3e-47
Identities = 102/248 (41%), Positives = 138/248 (55%), Gaps = 27/248 (10%)
Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
CI+ YTC C G+ L+ +GTRC+DVDEC PC G RC NSPGSFRC C
Sbjct: 561 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 614
Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
G+ + C+DV+EC R P +CENT GS+LC C G++ + G SC+D++E
Sbjct: 615 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 674
Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
C+ SP C + C N+ GS++C C G++ G C ED+DECA P G R
Sbjct: 675 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 725
Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
C N GSF C+CP +G+R G CQD+DEC C+ C N +G F+C+ CP
Sbjct: 726 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 780
Query: 558 ENYRRSAA 565
++ + A
Sbjct: 781 MGFQPNTA 788
Score = 135 bits (341), Expect = 8e-32
Identities = 76/207 (36%), Positives = 103/207 (49%), Gaps = 18/207 (8%)
Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
C + CG G RC++ P + C C +G+ C+DV+EC+R P +CEN+
Sbjct: 549 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 607
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
GS+ C C GFR C D++EC PC C N GS+ C C GYQ + G
Sbjct: 608 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 666
Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
+C+D+DEC G +C C N+PGSF+C CP +G+R G C +D+DEC
Sbjct: 667 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 719
Query: 535 NCSINETCFNIQGGFRCLAFECPENYR 561
C C N G F C CP +R
Sbjct: 720 PCGPGR-CDNTAGSFHC---ACPAGFR 742
Score = 112 bits (279), Expect = 1e-24
Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)
Query: 178 DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
D CR GP Q+C ++ C C GY +G +C+DV+EC +
Sbjct: 963 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 1021
Query: 233 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
C NT GS+RC +C GY+ T C+D+DEC + C +CQN GSF+C
Sbjct: 1022 CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1075
Query: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
C G+ G +C+D+NEC ++ C C N EGS+ C PN + +
Sbjct: 1076 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1129
Query: 352 TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
RCV A PP P GS R EC YF
Sbjct: 1130 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1185
Query: 391 D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
D I V EC G G C E LC G+ S
Sbjct: 1186 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1245
Query: 434 VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
D D++EC C S C N Y CYC GY + C D DECA
Sbjct: 1246 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1304
Query: 487 -LPTGGHICSYRCINIPGSFQCSC 509
GG RC+N GS+ C+C
Sbjct: 1305 PACEGG-----RCVNTVGSYHCTC 1323
Score = 70.9 bits (172), Expect = 3e-12
Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)
Query: 308 DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
D++EC L C G C+NT Y+C C GY+ + + C+D DECA EP
Sbjct: 1253 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1305
Query: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
+G RCVN+ GS+ C C+ DG R CV NE Q L C H
Sbjct: 1306 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1364
Query: 415 CENTLGSYL-CSCSVGFRLSVDGRSC 439
+ +Y C C G +D C
Sbjct: 1365 RLDRQATYTECCCLYGEAWGMDCALC 1390
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 342 GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
GRGY L G + DVDEC + K CVN+ + C C GYY+ C+D
Sbjct: 1238 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1296
Query: 400 VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
+EC G +C NT+GSY C+C L R C
Sbjct: 1297 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1336
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)
Query: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
AE CG RCV P F C C GY D CVD+NEC LC +C
Sbjct: 1534 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1593
Query: 416 ENTLGSYLCSCSVGF 430
NT GS+ C C GF
Sbjct: 1594 LNTDGSFRCICRPGF 1608
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)
Query: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
++ EC I C G C+ +TC+ C GY L+ CVD++EC A A
Sbjct: 1532 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1584
Query: 365 EPCGKGHRCVNSPGSFRCECKTGY 388
P RC+N+ GSFRC C+ G+
Sbjct: 1585 SPLCVNARCLNTDGSFRCICRPGF 1608
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)
Query: 459 GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
GSY Y+ +++ C +D C T G RC+ +P F C C GYRL
Sbjct: 1519 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1567
Query: 519 NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
C DI+EC +N C N G FRC+
Sbjct: 1568 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 398 VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
++ EC G G +C + C C G+RL + +C DINEC ++SP +
Sbjct: 1532 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590
Query: 452 QECANVYGSYQCYCRRGY 469
C N GS++C CR G+
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608
Score = 46.2 bits (108), Expect = 8e-05
Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 168 EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
E E E+ + D C G +C + C CF GY+L ++C D+NEC +
Sbjct: 1531 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1585
Query: 228 RL--GESCINTVGSFRC 242
L C+NT GSFRC
Sbjct: 1586 PLCVNARCLNTDGSFRC 1602
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
V +C +E G R V++P C TG F+ ++ C DV+EC G C H +C
Sbjct: 321 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 372
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
NT G Y C C GF L SC + + + PC
Sbjct: 373 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 409
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
GSY S + + ++ C ++ C++ C V + C C GY+L D+ + C
Sbjct: 1519 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1572
Query: 480 EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
DI+EC +C + RC+N GSF+C C
Sbjct: 1573 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1604
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)
Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
G+H+C +C LG+ P C +GF + G+C D++EC + C G C
Sbjct: 320 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 373
Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
NT G YTC C G+ L+ + C+ + PC
Sbjct: 374 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 409
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)
Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
G H C+L C +G+ D C TG+E + SC+D+DEC +G C
Sbjct: 320 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 373
Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
NT G + C C GF+ D + +CI + PC
Sbjct: 374 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 409
Score = 43.5 bits (101), Expect = 5e-04
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
+D+DEC+ +C NT + C C +G+ CID +EC C
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1307
Query: 320 PIGHTCINTEGSYTCQKNVP 339
G C+NT GSY C P
Sbjct: 1308 E-GGRCVNTVGSYHCTCEPP 1326
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)
Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
V++CQ LC + N+ + + C GF V+G SCED++EC++ Q ECA
Sbjct: 321 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 373
Query: 456 NVYGSYQCYCRRGYQL 471
N G Y C C G+ L
Sbjct: 374 NTRGGYTCVCPDGFLL 389
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)
Query: 252 YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
YE E C +D C +G C F CR C G+ D C+DIN
Sbjct: 1529 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1576
Query: 311 ECLSISAPCP--IGHTCINTEGSYTC 334
EC A P + C+NT+GS+ C
Sbjct: 1577 ECDEAEAASPLCVNARCLNTDGSFRC 1602
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)
Query: 112 CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
CC +G + G C G + + +++ C + G L G D + + ++
Sbjct: 1207 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1256
Query: 172 EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
+ + C+ G C +T C C GY + + C D +EC +C G
Sbjct: 1257 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1310
Query: 232 SCINTVGSFRC 242
C+NTVGS+ C
Sbjct: 1311 RCVNTVGSYHC 1321
Score = 38.9 bits (89), Expect = 0.013
Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)
Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
S+P ++ G C+ R G S + G+ +++ L G H C +
Sbjct: 273 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 332
Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
S + S CP+ R+ NG +C+D+DEC TG C E C N +GG+ C+ CP
Sbjct: 333 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 384
Query: 558 ENY 560
+ +
Sbjct: 385 DGF 387
Score = 37.0 bits (84), Expect = 0.048
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
C G++ ++ SCEDV+EC TG C+ GE C NT G + C C G+ L S
Sbjct: 344 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 394
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 231 bits (589), Expect = 1e-60
Identities = 132/372 (35%), Positives = 192/372 (51%), Gaps = 38/372 (10%)
Query: 190 CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
C +T C CF GY+ +C D++EC CR G +C+NT GSF+C C
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185
Query: 249 GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305
G+EL+ C DI+EC + C + C N +G+++C C G+ D G
Sbjct: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239
Query: 306 CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
C DI+EC+ ++ C C N+EGSY C +C GY L +G C D+DEC +
Sbjct: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292
Query: 366 PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425
C G +C N PG +RC C G+ + C+DVNEC +CENT GS++C
Sbjct: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351
Query: 426 CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C +G+ + C D++EC + C N+ GS++C CR G+ +G+ C D
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408
Query: 482 IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
+DEC+ G H CS +C+N PGS++C+C S G+ +G C D+DEC I+ C N
Sbjct: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462
Query: 540 ETCFNIQGGFRC 551
C N+ G +RC
Sbjct: 1463 GQCLNVPGAYRC 1474
Score = 228 bits (582), Expect = 9e-60
Identities = 152/460 (33%), Positives = 203/460 (44%), Gaps = 108/460 (23%)
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C G PC C + C+C G++ ++CED+NEC C C+NT
Sbjct: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271
Query: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294
GS+ C +C GY L ED CKD+DEC G+H+C +C+N +G+F C C
Sbjct: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323
Query: 295 KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
G + G C+D NEC + C G C+N GSY C+ C G+ + GT
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377
Query: 354 CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382
C+D + +E C G GH+C PG+ + C
Sbjct: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437
Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
GY DG D++EC+ P +C NT+GS+ C C VG+ + G SC D+
Sbjct: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
Query: 443 NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500
+ECS S PC+ C N GSYQC C RGY L + DG TC+D+DEC T H C + C+N
Sbjct: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549
Query: 501 IPGSFQCSCP----------------------------------------SSGYRLAPNG 520
G F C CP G+ L G
Sbjct: 2550 TLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATG 2609
Query: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
NC+D+DEC G H C C NI GG+RC CP+ Y
Sbjct: 2610 LNCEDVDEC-DGNHRC--QHGCQNILGGYRC---GCPQGY 2643
Score = 213 bits (541), Expect = 5e-55
Identities = 139/393 (35%), Positives = 185/393 (47%), Gaps = 57/393 (14%)
Query: 199 CSCFVGYQLLSDGVSCEDVNECITGSHS----CRLGESCINTVGSFRCQRDSSCGTGYEL 254
C C G+Q S G C D + + + C++ S N V C D G G++
Sbjct: 2363 CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422
Query: 255 ---------------------TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293
T D +DIDEC+ + N + C NT+GSFRC
Sbjct: 2423 ELCPLPGTAQYKKICPHGPGYTTDG--RDIDECKV-MPNLCTNGQCINTMGSFRCF---- 2475
Query: 294 CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352
CK G+ D G +CID++EC PC + C NTEGSY C +C RGY L E+G
Sbjct: 2476 CKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC-----SCPRGYVLQEDGK 2528
Query: 353 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412
C D+DEC C CVN+ G F C+C G F C+D NEC P LCG
Sbjct: 2529 TCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG--FTQHHTACIDNNECGSQPS-LCG 2583
Query: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECANVYGSYQCYCRRGY 469
K C+NT GS+ C C GF L G +CED++EC + C C N+ G Y+C C +GY
Sbjct: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
+ C D +EC+ P S C N GS++C+CPS G+ C D++EC
Sbjct: 2644 -IQHYQWNQCVDENECSNPNACGSAS--CYNTLGSYKCACPS-GFSFDQFSSACHDVNEC 2699
Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
+ + C N C N +GG+ C CP Y R
Sbjct: 2700 SSSKNPC--NYGCSNTEGGYLC---GCPPGYYR 2727
Score = 212 bits (539), Expect = 8e-55
Identities = 144/449 (32%), Positives = 195/449 (43%), Gaps = 103/449 (22%)
Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
C D C C G++ D C DV+EC H C G +C NTVGS+ C C
Sbjct: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNG-TCKNTVGSYNCL----CY 1960
Query: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCID 308
G+ELT +N C DIDEC S + C N +GSF+C C G+ G NCID
Sbjct: 1961 PGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL----CNEGYELTPDGKNCID 2016
Query: 309 INECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE--------- 359
NEC+++ C G TC N EGS+ C C GY + E C+D++E
Sbjct: 2017 TNECVALPGSCSPG-TCQNLEGSFRCI-----CPPGYEVKSEN--CIDINECDEDPNICL 2068
Query: 360 --------------CAPPAEPCGKGHRCVNSPGSF------RCECKTGYYFDGISRMCV- 398
C P G RC ++ SF +C F+ C
Sbjct: 2069 FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCC 2128
Query: 399 ------------------------------------------DVNECQRYPGRLCGHKCE 416
DVNEC PG +C
Sbjct: 2129 SKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCI 2188
Query: 417 NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANVYGSYQCYCRRGYQLSDV 474
NT GS+ C C +G+ L G C D +ECS +PC C NV GS++C C G++ +
Sbjct: 2189 NTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM 2248
Query: 475 DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534
+ CEDI+ECA +C++RC+N GS++C+CP GY L + + C+D+DEC G+H
Sbjct: 2249 --MNCEDINECA--QNPLLCAFRCMNTFGSYECTCP-IGYALREDQKMCKDLDECAEGLH 2303
Query: 535 NC-SINETCFNIQGGFRCLAFECPENYRR 562
+C S C N+ G F C+ CP R
Sbjct: 2304 DCESRGMMCKNLIGTFMCI---CPPGMAR 2329
Score = 207 bits (528), Expect = 2e-53
Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)
Query: 13 PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68
PLL GG V+ + + C GH ++ ++DC + EC + C
Sbjct: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215
Query: 69 CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119
C + + C+ DR C +G + T + C C G A
Sbjct: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274
Query: 120 QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168
G+SC + G QC + +R C G + D ++
Sbjct: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325
Query: 169 EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
+ D LN C G +C +T +C C +GY + C DV+EC G+H+C
Sbjct: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
Query: 228 RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287
+ SC+N GSF+C SC G+ + C D+DEC +G H C + C NT GS+R
Sbjct: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
Query: 288 CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347
C C GF D C D++EC C G C+N G+Y C+ C G+
Sbjct: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482
Query: 348 NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407
+ C D+DEC+ C G C N PG F C C GY D C D++EC P
Sbjct: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539
Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456
C NT G Y C+C F+L+ G C D + C S C+ E
Sbjct: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
Query: 457 VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486
C C G Y L + + EDIDEC
Sbjct: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
Query: 487 LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546
L GG+ CIN GSFQC CP GY L+ + R C+DIDEC C TC+N
Sbjct: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712
Query: 547 GGFRCLAFECPENY 560
G + C+ CP Y
Sbjct: 1713 GNYTCI---CPPEY 1723
Score = 201 bits (512), Expect = 1e-51
Identities = 146/443 (32%), Positives = 196/443 (44%), Gaps = 99/443 (22%)
Query: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237
+C ++ C C G L G C D+ +ECI ++C V
Sbjct: 970 RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
Query: 238 GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278
G+ C+ GT G LT KDI+EC++ C
Sbjct: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088
Query: 279 CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337
C+NT+GSF+CR C SGF D NC DI+EC C G C+NT GS+ C+
Sbjct: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141
Query: 338 VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393
C GY E G C+D+DEC C +G CVN+ GSF+C+C G+
Sbjct: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
Query: 394 SRMCVDVNEC---------------------------QRYPGRL--------------CG 412
CVD+NEC Q P R C
Sbjct: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
Query: 413 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGY 469
+C N+ GSY CSCS G+ L DGRSC DI+EC ++P C +C N+ G Y+C C G+
Sbjct: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGF 1314
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE 528
++ +D TC D++EC L +IC + C N GSF C C GY + C D+DE
Sbjct: 1315 -MASMDMKTCIDVNECDL--NSNICMFGECENTKGSFICHC-QLGYSVKKGTTGCTDVDE 1370
Query: 529 CVTGIHNCSINETCFNIQGGFRC 551
C G HNC ++ +C NI G F+C
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKC 1393
Score = 196 bits (497), Expect = 6e-50
Identities = 124/364 (34%), Positives = 170/364 (46%), Gaps = 48/364 (13%)
Query: 180 CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233
C GG QC + +C GY +DG D++EC + C G+ C
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465
Query: 234 INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
INT+GSFRC C GY SC D+DEC C ++IC+NT GS++C
Sbjct: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515
Query: 293 QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
C G++ G C D++EC + C C+NT G +TC+ C G+ +
Sbjct: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566
Query: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
T C+D +EC CG C N+PGSF CEC+ G+ D C DV+EC C
Sbjct: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD--GNHRC 2624
Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469
H C+N LG Y C C G+ C D NECS+ + C S C N GSY+C C G+
Sbjct: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
D C D++EC+ + + C+Y C N G + C CP YR+ C
Sbjct: 2685 SF-DQFSSACHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733
Query: 530 VTGI 533
V+G+
Sbjct: 2734 VSGM 2737
Score = 194 bits (492), Expect = 2e-49
Identities = 138/435 (31%), Positives = 197/435 (45%), Gaps = 70/435 (16%)
Query: 161 TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
T K ++++E +E P + C G C + C C G+ + CED++EC
Sbjct: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854
Query: 221 ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
G + C+ CIN+ GS+RC+ C G++L+ + +C D +EC I N +C
Sbjct: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909
Query: 281 NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
+ GS++C C +GF QD C+D++EC PC G TC NT GSY C
Sbjct: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958
Query: 339 PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
C G+ L C+D+DEC+ + RC N GSF+C C GY + C+
Sbjct: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015
Query: 399 DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455
D NEC PG C+N GS+ C C G+ V +C DINEC P C
Sbjct: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073
Query: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGHICSYRCI--NIP 502
N G +QC C G+ LSD +G C D +C++P + +C +P
Sbjct: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
Query: 503 G----------------SFQCSCPSSGYRLAPNGRNC-QDIDECVTGIHNCSINETCFNI 545
G +FQ CP G+ P+ + +D++EC+ CS N C N
Sbjct: 2133 GEGWGDPCELCPKDDEVAFQDLCP-YGHGTVPSLHDTREDVNECLESPGICS-NGQCINT 2190
Query: 546 QGGFRCLAFECPENY 560
G FRC ECP Y
Sbjct: 2191 DGSFRC---ECPMGY 2202
Score = 184 bits (467), Expect = 2e-46
Identities = 130/381 (34%), Positives = 174/381 (45%), Gaps = 67/381 (17%)
Query: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274
+ ++ C ++ C G CI TV S+RC+ C GY+ + C D+DEC S N
Sbjct: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544
Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333
+ C NT GS+ C+ C +GF + CIDI+EC+ C G C+NT+GS+
Sbjct: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599
Query: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393
C C G+ L +G CVD DEC C G C+N GSF+C CK G+
Sbjct: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652
Query: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442
R C DV+ECQ PG C N+ GS+ C C G + +DGR C D
Sbjct: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
Query: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
+EC PC A + C G ++ VDG
Sbjct: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767
Query: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
DI+ECAL IC+ C N+ GS++C+C +SGY +GRNC DIDEC+ C N
Sbjct: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823
Query: 540 ETCFNIQGGFRCLAFECPENY 560
C N G + C CP Y
Sbjct: 824 GLCRNTPGSYSC---TCPPGY 841
Score = 170 bits (430), Expect = 4e-42
Identities = 135/409 (33%), Positives = 177/409 (43%), Gaps = 73/409 (17%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C C +T C C G+Q +C D++ECI C+ G C+NT
Sbjct: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GSF+C C G+ELT D +C D DEC + + CL + +C N GSF+C CK
Sbjct: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645
Query: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
GF+ G C D++EC + C GH CIN+EGS+ C +C G + +G CV
Sbjct: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698
Query: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386
D EC G G C P E C +
Sbjct: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758
Query: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446
G GI+ D+NEC P CEN GSY C+C+ G+ GR+C DI+EC
Sbjct: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
Query: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503
+ + C N GSY C C GY + + TCEDI+EC + C N G
Sbjct: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871
Query: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF-NIQGGFRC 551
SF C C S G +L+ G C D S+ TC+ NIQ RC
Sbjct: 872 SFNCEC-SPGSKLSSTGLICID-----------SLKGTCWLNIQDS-RC 907
Score = 164 bits (416), Expect = 2e-40
Identities = 135/444 (30%), Positives = 187/444 (42%), Gaps = 91/444 (20%)
Query: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
QC + C C +G+ SD SC+D++EC + + C G +C N G F C C
Sbjct: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517
Query: 249 GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302
GYEL +C DIDEC I NC+ + +C NT G + C P Q G + +
Sbjct: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
Query: 303 LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337
+GNC + N + + S C +G TC +N+ YT
Sbjct: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
Query: 338 VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397
G G+ N D+DEC C +G C+N+ GSF+CEC GYY +R+C
Sbjct: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
Query: 398 VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450
D++EC +PG +CG C NTLG+Y C C + G +C D+ + + + C
Sbjct: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
Query: 451 SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480
E C C Y + CE
Sbjct: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
Query: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
DIDEC G IC+ CIN GSF+C CP +G+ C+DIDEC G + C N
Sbjct: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
Query: 540 ETCFNIQGGFRCLAFECPENYRRS 563
C N G +RC EC ++ S
Sbjct: 1865 ADCINSPGSYRC---ECAAGFKLS 1885
Score = 147 bits (371), Expect = 3e-35
Identities = 168/605 (27%), Positives = 233/605 (38%), Gaps = 128/605 (21%)
Query: 27 VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81
V+ D + C G + T K+C + EC M C ++ C G
Sbjct: 592 VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
Query: 82 ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131
LA + D C TP +G + E +F RC C G A G+ C + M
Sbjct: 647 FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702
Query: 132 VGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCR 191
G + + CV+ G + +++ N G PC+
Sbjct: 703 RSTCYGGIKKGVCVRPFP------GAVTKSECCCA----------NPDYGFGEPCQPCPA 746
Query: 192 DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTG 251
E C G + DG D+NEC C G C N GS+RC +C +G
Sbjct: 747 KNSAEFHGLCSSGVGITVDG---RDINECALDPDICANG-ICENLRGSYRC----NCNSG 798
Query: 252 YEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI-QDALGNCIDI 309
YE +C DIDEC C + +C+NT GS+ C C G++ + C DI
Sbjct: 799 YEPDASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCT----CPPGYVFRTETETCEDI 853
Query: 310 NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD------------- 356
NEC S PC G C N GS+ C+ C G L+ G C+D
Sbjct: 854 NECES--NPCVNG-ACRNNLGSFNCE-----CSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
Query: 357 -----VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM----CVDVNECQRYP 407
++ +E C SP RCE T G++R+ C DVNEC+ +P
Sbjct: 906 RCEVNINGATLKSECCATLGAAWGSPCE-RCELDTACP-RGLARIKGVTCEDVNECEVFP 963
Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI--NECSSSPCSQECAN--------- 456
G +C N+ GS+ C C G L GR C DI +C EC +
Sbjct: 964 GVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMD 1023
Query: 457 --------VYGS------------YQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491
+G+ Y+ C RG ++ V +DI+EC G
Sbjct: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082
Query: 492 HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
+C+Y +C N GSF+C C +SG+ L RNC DIDEC C + C N G F
Sbjct: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139
Query: 551 CLAFE 555
C FE
Sbjct: 1140 CECFE 1144
Score = 144 bits (363), Expect = 2e-34
Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)
Query: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271
+C+DV+EC C+ G +CINTVGSF C+ C G++ +E C+DIDEC S I
Sbjct: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326
Query: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305
C NT+GS+ RC + C SG + Q+ G
Sbjct: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
Query: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340
C + C I CP+ + E C +P
Sbjct: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443
Query: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396
G G GT + + P G G SPG G G++ +
Sbjct: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491
Query: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455
++ C+ + +C T+ SY C C++G++ +G C D++EC+S+PC+ +C
Sbjct: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550
Query: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514
N GSY C C G+Q + C DIDEC G +C + RC+N GSFQC C ++G+
Sbjct: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606
Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
L +G+NC D DEC T N +N C N G F+C+
Sbjct: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642
Score = 99.0 bits (245), Expect = 1e-20
Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259
C G++ L G N+CI C N+ G C R + C + +++
Sbjct: 97 CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142
Query: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312
K I +C N C D CQ +G++ +P + C++G G CI N C
Sbjct: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196
Query: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369
C G T E Y C V N L G C CA G
Sbjct: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248
Query: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429
H C P + C+ G+ + + C DV+ECQ PG G C NT+GS+ C C G
Sbjct: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
Query: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
+ S + CEDI+ECS P C EC+N GSY C C RGY ++ DG C ID+
Sbjct: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363
Query: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509
+ + RC +PG QC C
Sbjct: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390
Score = 94.4 bits (233), Expect = 3e-19
Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)
Query: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
RC GG C QC+ C G + +G C++ CI G + C +C+
Sbjct: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
+C+RD G C + ++N + CQ L C L C
Sbjct: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241
Query: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
+ I A G+ PC + C C RG+ N C
Sbjct: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275
Query: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
DVDEC C +G C+N+ GSF C C G+ ++ C D++EC PG +C
Sbjct: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468
NT+GSY C C G+ S DG C D + + C+QE QC C G
Sbjct: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 87.8 bits (216), Expect = 2e-17
Identities = 95/297 (31%), Positives = 125/297 (42%), Gaps = 75/297 (25%)
Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
IC+N+ G C RP + C SG I G+ I +C S C G TC + CQ
Sbjct: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165
Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388
C +GY GT C P E C G RC+ G RC C G+
Sbjct: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208
Query: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446
Y G V+ CQ G+L G C TL C ++G G CE C
Sbjct: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255
Query: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505
+ P CRRG+ + ++ C+D+DEC G IC CIN GSF
Sbjct: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299
Query: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENY 560
+C CP +G++ + + C+DIDEC + GI C E C N G + C+ CP Y
Sbjct: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGY 349
Score = 68.9 bits (167), Expect = 1e-11
Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)
Query: 36 CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73
CC DG R HQ + C LP Y T+ + EC+++ C C + +
Sbjct: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
Query: 74 EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124
C T IS + + D C+ +P N + T C C G Q G+
Sbjct: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528
Query: 125 SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158
+C+ + + G+ C C+ + E G G
Sbjct: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588
Query: 159 QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210
Q T E ++ + LN D C G C+ C++ C C GY
Sbjct: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
Query: 211 GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269
C D NEC + ++C SC NT+GS++C +C +G+ + ++C D++EC S
Sbjct: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702
Query: 270 IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325
+ C ++ C NT G + C C G+ + G+C+ N+ +S +
Sbjct: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756
Query: 326 INTEGSYTCQKN 337
++ E Y C+ N
Sbjct: 2757 LSPEACYECKIN 2768
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 230 bits (586), Expect = 3e-60
Identities = 120/311 (38%), Positives = 166/311 (53%), Gaps = 51/311 (16%)
Query: 293 QCKSGFIQDAL-GNCIDINECLSISAPCPIGHTCINTEGSYTC----------------- 334
QC +GF D G C+DI+EC +I C C+N G Y C
Sbjct: 26 QCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYS 85
Query: 335 ------------QKNVPN---------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRC 373
+ PN C GY + +E +CVDVDECA + C C
Sbjct: 86 TPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATDSHQCNPTQIC 144
Query: 374 VNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
+N+ G + C C GY+ + C+D++EC RY C C N GSY C+C+ GF L+
Sbjct: 145 INTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YCQQLCANVPGSYSCTCNPGFTLN 199
Query: 434 VDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
DGRSC+D+NEC++ +PC Q C N YGS+ C C GY+L + DGV C D+DEC+
Sbjct: 200 EDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE-DGVHCSDMDECSFSE--F 256
Query: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
+C + C+N PG++ CSCP GY L + R+CQDI+EC H C++ +TC+N+QGGF+C+
Sbjct: 257 LCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
Query: 553 -AFECPENYRR 562
C E Y R
Sbjct: 316 DPIRCEEPYLR 326
Score = 172 bits (435), Expect = 1e-42
Identities = 108/322 (33%), Positives = 146/322 (45%), Gaps = 64/322 (19%)
Query: 233 CINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
C+ + G+ + Q C G++L + C DIDEC + C D +C N G + C P+
Sbjct: 16 CLPSPGNAQAQ----CTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPR 71
Query: 292 ---------------------------------------LQCKSGFIQDALGNCIDINEC 312
L C+ G+ D C+D++EC
Sbjct: 72 TNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDEC 131
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
+ S C CINTEG YTC +C GY L E +C+D+DEC C +
Sbjct: 132 ATDSHQCNPTQICINTEGGYTC-----SCTDGYWLLE--GQCLDIDECR--YGYCQQ--L 180
Query: 373 CVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL 432
C N PGS+ C C G+ + R C DVNEC C C NT GS++C C G+ L
Sbjct: 181 CANVPGSYSCTCNPGFTLNEDGRSCQDVNECA--TENPCVQTCVNTYGSFICRCDPGYEL 238
Query: 433 SVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 490
DG C D++ECS S C EC N G+Y C C GY L D D +C+DI+EC
Sbjct: 239 EEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLD-DNRSCQDINEC--EHR 295
Query: 491 GHICSYR--CINIPGSFQCSCP 510
H C+ + C N+ G F+C P
Sbjct: 296 NHTCNLQQTCYNLQGGFKCIDP 317
Score = 169 bits (429), Expect = 5e-42
Identities = 108/335 (32%), Positives = 145/335 (43%), Gaps = 71/335 (21%)
Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
C + C G+ L C D++EC T +CR C+N G + C
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 243 --------------------------------QRDSSCGTGYELTEDNSCKDIDECESGI 270
R C GY++ E N C D+DEC +
Sbjct: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEG 330
H C P IC NT G + C C G+ G C+DI+EC C C N G
Sbjct: 136 HQCNPTQICINTEGGYTC----SCTDGYWL-LEGQCLDIDECR--YGYCQ--QLCANVPG 186
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
SY+C C G+ LNE+G C DV+ECA PC + CVN+ GSF C C GY
Sbjct: 187 SYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSFICRCDPGYEL 238
Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SS 448
+ C D++EC + LC H+C N G+Y CSC G+ L D RSC+DINEC +
Sbjct: 239 EEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNH 297
Query: 449 PCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C+ Q C N+ G ++C +D + CE+
Sbjct: 298 TCNLQQTCYNLQGGFKC----------IDPIRCEE 322
Score = 103 bits (256), Expect = 5e-22
Identities = 73/227 (32%), Positives = 109/227 (48%), Gaps = 33/227 (14%)
Query: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
+ E+++ ++V+E D + +C Q C +T CSC GY LL C D+
Sbjct: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169
Query: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
+EC G C+ + C N GS+ C +C G+ L ED SC+D++EC + + C+
Sbjct: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE-NPCVQ- 219
Query: 277 FICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
C NT GSF CR C G+ + G +C D++EC C H C+N G+Y C
Sbjct: 220 -TCVNTYGSFICR----CDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQPGTYFC- 271
Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382
+C GY L ++ C D++EC C C N G F+C
Sbjct: 272 ----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
Score = 94.4 bits (233), Expect = 3e-19
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
+ C PC Q C +T +C C GY+L DGV C D++EC C+ C+N
Sbjct: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
G++ C SC GY L +DN SC+DI+ECE H C C N G F+C ++C+
Sbjct: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322
Query: 297 GFIQDALGNCI 307
+++ + C+
Sbjct: 323 PYLRISDNRCM 333
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 228 bits (580), Expect = 1e-59
Identities = 159/452 (35%), Positives = 211/452 (46%), Gaps = 93/452 (20%)
Query: 164 IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
I E++EEQ P + DRC G GP C + D C C GYQL
Sbjct: 822 IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879
Query: 209 SDGVSCEDVNECI-------------TGSHSCRL-------------------------- 229
C D NEC+ GS+SC
Sbjct: 880 PSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGV 939
Query: 230 --GESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287
G C NT GS+ C+ C GY + C+DI+EC PD C N+ GS+
Sbjct: 940 CSGGQCTNTEGSYHCE----CDQGYIMVRKGHCQDINECRH--PGTCPDGRCVNSPGSYT 993
Query: 288 CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347
C L C+ G+ + G+C+D+NECL+ C G C N EGS+ C +C +GY +
Sbjct: 994 C---LACEEGY-RGQSGSCVDVNECLT-PGVCAHG-KCTNLEGSFRC-----SCEQGYEV 1042
Query: 348 NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQRY 406
+ C DVDECA A C G C+N+ GSF C C+ GY+ + C D++EC +
Sbjct: 1043 TSDEKGCQDVDECASRAS-CPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDEC-AF 1099
Query: 407 PGRLCGHKCENTLGSYLC-SCSVGFRLSVDGRSCEDINEC---SSSPCSQECANVYGSYQ 462
PG C NT GS+ C C G+R S G SCED++EC SS EC N GSYQ
Sbjct: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
Query: 463 CYCRRGYQLSDVDGVTCEDIDECALPTGGHICS--YRCINIPGSFQCSCPSSGYRLAPNG 520
C C +G+QL+ +G CED++EC G C+ C+N GSF C C + G+ A G
Sbjct: 1160 CLCPQGFQLA--NGTVCEDVNEC---MGEEHCAPHGECLNSHGSFFCLC-APGFVSAEGG 1213
Query: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
+CQD+DEC T + + C N +G F CL
Sbjct: 1214 TSCQDVDECAT--TDPCVGGHCVNTEGSFNCL 1243
Score = 222 bits (566), Expect = 6e-58
Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
+ C G C +C + CSC GY++ SD C+DV+EC + + SC G C+NT
Sbjct: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069
Query: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
GSF C S+C GY + ED +C+D+DEC P +C NT GSF C+ C
Sbjct: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121
Query: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
G+ LG +C D++EC + C +G C NT GSY C C +G+ L GT C
Sbjct: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174
Query: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
DV+EC E C C+NS GSF C C G+ C DV+EC + GH
Sbjct: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232
Query: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
C NT GS+ C C GF+ S + C DI+EC P + +C N GSY+C C+ G
Sbjct: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
Query: 469 YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
+ ++ C DIDECA T G H C N GSF+C C G+ ++P+G +C D+
Sbjct: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346
Query: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
+EC + C C N++G F CL E Y
Sbjct: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379
Score = 204 bits (518), Expect = 2e-52
Identities = 137/364 (37%), Positives = 187/364 (51%), Gaps = 40/364 (10%)
Query: 212 VSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGI 270
+S ++ C G+ + +C+N +RC C GY+L + C D +EC
Sbjct: 840 LSTPGIDRCAAGATNVCGPGTCVNLPDGYRCV----CSPGYQLHPSQAYCTDDNECLRD- 894
Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG---NCIDINECLSISAPCPIGHTCIN 327
C C N +GS+ C C G+ G C DINEC C G C N
Sbjct: 895 -PCKGKGRCINRVGSYSCF----CYPGYTLATSGATQECQDINECEQPGV-CS-GGQCTN 947
Query: 328 TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKT 386
TEGSY C+ C +GY + +G C D++EC P C G RCVNSPGS+ C C+
Sbjct: 948 TEGSYHCE-----CDQGYIMVRKG-HCQDINECRHPGT-CPDG-RCVNSPGSYTCLACEE 999
Query: 387 GYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
GY G S CVDVNEC PG +C H KC N GS+ CSC G+ ++ D + C+D++EC
Sbjct: 1000 GYR--GQSGSCVDVNECLT-PG-VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
Query: 446 SS--SPCSQECANVYGSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
+S S + C N GS+ C C GY +++ DG CED+DECA P G S C N
Sbjct: 1056 ASRASCPTGLCLNTEGSFACSACENGYWVNE-DGTACEDLDECAFP--GVCPSGVCTNTA 1112
Query: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
GSF C GYR +P G +C+D+DEC +C + C N G ++CL CP+ ++
Sbjct: 1113 GSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL---CPQGFQL 1168
Query: 563 SAAT 566
+ T
Sbjct: 1169 ANGT 1172
Score = 182 bits (461), Expect = 9e-46
Identities = 140/440 (31%), Positives = 189/440 (42%), Gaps = 87/440 (19%)
Query: 178 DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
D C G C C +T C C GY+ G SCEDV+EC SC LG C N
Sbjct: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
TVGS++C C G++L C+D++EC G +C P C N+ GSF C C
Sbjct: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204
Query: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
GF+ G +C D++EC + PC GH C+NTEGS+ C C G+ + E C
Sbjct: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257
Query: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
VD+DEC +P +C NSPGS+RC C+ G++ + C+D++EC +CG
Sbjct: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314
Query: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
C+NT GS+ C C GF +S G C D+NEC + C C NV GS+ C C
Sbjct: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
Query: 468 GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
+ D C + + E PTG H + ++ G CS
Sbjct: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
Query: 509 ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
CPS + P+G+ D DECV
Sbjct: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
Query: 533 IHNCSINETCFNIQGGFRCL 552
N C N G+ CL
Sbjct: 1493 GPGLCPNGRCLNTVPGYVCL 1512
Score = 115 bits (288), Expect = 1e-25
Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)
Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
D C PC C +T C C G+Q + C D++EC G C + C N
Sbjct: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278
Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
+ GS+RC C G+ + + C DIDEC + C C NT GSFRC C
Sbjct: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331
Query: 296 SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
GF I + +C+D+NEC + A C C N EGS+ C ++ + H G
Sbjct: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
Query: 352 TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
+ E AP C G + C + G C C G + +
Sbjct: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
Query: 397 C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
C D +EC + LC + +C NT+ Y+
Sbjct: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510
Query: 424 CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
C C+ GF + CED +EC C EC N GS+ C+C L D+ C +
Sbjct: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569
Query: 483 DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
H IC + N CS P G+R CQD
Sbjct: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613
Score = 60.8 bits (146), Expect = 3e-09
Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
AE CG + RCV + C+C G+ D CVDVNEC P LC H C
Sbjct: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793
Query: 416 ENTLGSYLCSCSVGF 430
ENT GSY C CS G+
Sbjct: 1794 ENTEGSYRCHCSPGY 1808
Score = 50.4 bits (119), Expect = 4e-06
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
C+ YTC +C G+ L+ CVDV+EC PA C G+ C N+ GS+R
Sbjct: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801
Query: 382 CECKTGY 388
C C GY
Sbjct: 1802 CHCSPGY 1808
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 390 FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
F+G+ + C +N C+ +C Y C C GF+L +C D+NEC
Sbjct: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
Query: 447 SSPC----SQECANVYGSYQCYCRRGY 469
+ P C N GSY+C+C GY
Sbjct: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
+++ APCP S + C +GY LN T C D++EC K
Sbjct: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635
Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
CVN+ GS+ C C+ G D CV G C +LG C+ + R
Sbjct: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690
Query: 432 LSVDGRSCEDINECSSSPCSQ 452
++ C + + S C +
Sbjct: 691 ITKQICCCSRVGKAWGSECEK 711
Score = 44.3 bits (103), Expect = 3e-04
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)
Query: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
+L+C G+ + L +C DINECL++ C C+NT GSY C C G L+
Sbjct: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657
Query: 351 GTRCV 355
+RCV
Sbjct: 658 RSRCV 662
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)
Query: 251 GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
G+E + C ++ CE+G C + C C GF DA C+D+
Sbjct: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775
Query: 310 NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
NEC ++ P C G+ C NTEGSY C +C GY
Sbjct: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808
Score = 44.3 bits (103), Expect = 3e-04
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
+C + C CF G+QL + ++C DVNEC + G + C NT GS+RC
Sbjct: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803
Query: 247 SCGTGY 252
C GY
Sbjct: 1804 -CSPGY 1808
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
+ C +N C + C V Y C C G+QL D + C D++EC G +
Sbjct: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786
Query: 494 CSYR--CINIPGSFQCSCPSSGY 514
C N GS++C C S GY
Sbjct: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808
Score = 36.6 bits (83), Expect = 0.063
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
C+DINEC + + EC N GSY C CR G L
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654
Score = 36.2 bits (82), Expect = 0.082
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 6/77 (7%)
Query: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
+PC A+ V + Q C +GY+ ++ C+DI+EC T G C+N GS+
Sbjct: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645
Query: 507 CSCPSSGYRLAPNGRNC 523
C+C G L P+ C
Sbjct: 646 CTC-RPGLMLDPSRSRC 661
Score = 35.0 bits (79), Expect = 0.18
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
C GY+ L+ C+D+NEC+T C+ E C+NT GS+ C +C G L S
Sbjct: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659
Query: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
C S + +C +LG C
Sbjct: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683
Score = 34.3 bits (77), Expect = 0.31
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 11/87 (12%)
Query: 248 CGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI 307
C GY+ C+DI+EC + D C NT GS+ C C+ G + D
Sbjct: 608 CPQGYKRLNLTHCQDINECLT--LGLCKDAECVNTRGSYLC----TCRPGLMLDP----- 656
Query: 308 DINECLSISAPCPIGHTCINTEGSYTC 334
+ C+S A + C + G TC
Sbjct: 657 SRSRCVSDKAISMLQGLCYRSLGPGTC 683
Score = 31.6 bits (70), Expect = 2.0
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
Q CP RL N +CQDI+EC+T + C E C N +G + C
Sbjct: 605 QLECPQGYKRL--NLTHCQDINECLT-LGLCKDAE-CVNTRGSYLC 646
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 224 bits (571), Expect = 2e-58
Identities = 123/293 (41%), Positives = 157/293 (53%), Gaps = 36/293 (12%)
Query: 293 QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV------------- 338
+C G+ D +C D+NECL+I C CIN G Y C
Sbjct: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
Query: 339 --------PN-CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
PN C GY +++ + CVDVDECA C C N PGS++C C GY
Sbjct: 98 PPVPPAQHPNPCPPGYEPDDQDS-CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
Query: 390 FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SS 448
I CVD++EC RY R C H+C N GS+ C C GF+L + RSC D+NEC +
Sbjct: 157 --KIGPECVDIDEC-RY--RYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA 211
Query: 449 PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCS 508
PC Q C N YG++ C C +GY+L DG +C DIDEC+ + ++C YRC+N PG F C
Sbjct: 212 PCEQRCFNSYGTFLCRCHQGYELHR-DGFSCSDIDECSYSS--YLCQYRCVNEPGRFSCH 268
Query: 509 CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL-AFECPENY 560
CP GY+L R CQDIDEC +G H CS +TC N GG+RC+ C E Y
Sbjct: 269 CPQ-GYQLLAT-RLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPY 319
Score = 182 bits (461), Expect = 9e-46
Identities = 105/290 (36%), Positives = 140/290 (48%), Gaps = 45/290 (15%)
Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ----------- 293
+ C GYE D+ C+D++EC + C + C N G + C P+
Sbjct: 37 TECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGP 96
Query: 294 ------------CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
C G+ D +C+D++EC C C N GSY C C
Sbjct: 97 PPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC-----TC 151
Query: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
GY + G CVD+DEC C HRCVN PGSFRC+C+ G+ +R CVDVN
Sbjct: 152 PDGYR--KIGPECVDIDECR--YRYCQ--HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205
Query: 402 ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYG 459
EC G C +C N+ G++LC C G+ L DG SC DI+ECS S C C N G
Sbjct: 206 ECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG 263
Query: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS--YRCINIPGSFQC 507
+ C+C +GYQL + C+DIDEC +G H CS C+N G ++C
Sbjct: 264 RFSCHCPQGYQL--LATRLCQDIDEC--ESGAHQCSEAQTCVNFHGGYRC 309
Score = 171 bits (432), Expect = 2e-42
Identities = 104/292 (35%), Positives = 140/292 (47%), Gaps = 50/292 (17%)
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------------------ 242
C GY+ D C DVNEC+T +C+ CIN G + C
Sbjct: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
Query: 243 -----QRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
Q + C GYE + +SC D+DEC +H+C P C N GS++C C G
Sbjct: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC----TCPDG 154
Query: 298 FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
+ + C+DI+EC H C+N GS+ CQ C G+ L CVDV
Sbjct: 155 Y-RKIGPECVDIDECRYRYCQ----HRCVNLPGSFRCQ-----CEPGFQLGPNNRSCVDV 204
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQRYPGRLCGHKC 415
+EC A PC + RC NS G+F C C GY + DG S C D++EC Y LC ++C
Sbjct: 205 NECDMGA-PCEQ--RCFNSYGTFLCRCHQGYELHRDGFS--CSDIDECS-YSSYLCQYRC 258
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSS--PCS--QECANVYGSYQC 463
N G + C C G++L + R C+DI+EC S CS Q C N +G Y+C
Sbjct: 259 VNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309
Score = 103 bits (257), Expect = 4e-22
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
+ C G PC+Q+C ++ +C C GY+L DG SC D++EC S+ C+ C+N
Sbjct: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262
Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
G F C C GY+L C+DIDECESG H C C N G +RC +C
Sbjct: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318
Query: 298 FIQDALGNCI 307
+IQ + C+
Sbjct: 319 YIQVSENRCL 328
Score = 93.2 bits (230), Expect = 6e-19
Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C+ +C + C C G+QL + SC DVNEC G+ C + C N+ G+F C+
Sbjct: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227
Query: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
C GYEL D SC DIDEC + C + C N G F C C G+ A
Sbjct: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279
Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C DI+EC S + C TC+N G Y RCVD + C P
Sbjct: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 215 bits (548), Expect = 8e-56
Identities = 133/358 (37%), Positives = 179/358 (50%), Gaps = 43/358 (12%)
Query: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESCINTVG 238
C GG C G C C G+Q G C+ DV+EC T + C+ C+NT G
Sbjct: 133 CFHGGRCVP-----GSAQPCHCPPGFQ----GPRCQYDVDECRTHNGGCQ--HRCVNTPG 181
Query: 239 SFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
S+ C+ C G+ L T+ +C I+ C G C + Q T+ RC QC+ G
Sbjct: 182 SYLCE----CKPGFRLHTDSRTCLAINSCALGNGGCQHHCV-QLTITRHRC----QCRPG 232
Query: 298 F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356
F +Q+ +C+ + C + + C H C G C+ C GY L +G C D
Sbjct: 233 FQLQEDGRHCVRRSPCANRNGSCM--HRCQVVRGLARCE-----CHVGYQLAADGKACED 285
Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-----VNECQRYPGRLC 411
VDECA C H C+N+ GSF+C C GY R C VN C+ G C
Sbjct: 286 VDECAAGLAQCA--HGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGG-C 342
Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE-CANVYGSYQCYCRRGYQ 470
H C +T LC+C G+ L D R+C D+++C+ SPC Q+ C N G Y+C C GY+
Sbjct: 343 SHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYR 402
Query: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE 528
LS DG CED+DECA GG C + C N+ GSFQCSC +GYRL + R C ++E
Sbjct: 403 LS-ADGCGCEDVDECASSRGG--CEHHCTNLAGSFQCSC-EAGYRLHEDRRGCSPLEE 456
Score = 180 bits (456), Expect = 4e-45
Identities = 112/309 (36%), Positives = 146/309 (47%), Gaps = 35/309 (11%)
Query: 262 DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCP 320
D+DEC + HN C NT GS+ C +CK GF + C+ IN C + C
Sbjct: 161 DVDECRT--HNGGCQHRCVNTPGSYLC----ECKPGFRLHTDSRTCLAINSCALGNGGCQ 214
Query: 321 IGHTCIN-TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379
H C+ T + CQ C G+ L E+G CV CA C HRC G
Sbjct: 215 --HHCVQLTITRHRCQ-----CRPGFQLQEDGRHCVRRSPCANRNGSCM--HRCQVVRGL 265
Query: 380 FRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
RCEC GY + C DV+EC + C H C NT GS+ C C G+ L DGR C
Sbjct: 266 ARCECHVGYQLAADGKACEDVDECAAGLAQ-CAHGCLNTQGSFKCVCHAGYELGADGRQC 324
Query: 440 -----EDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
E +N C ++ CS C++ C C RGY+L D D TC D+D+CA
Sbjct: 325 YRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYEL-DTDQRTCIDVDDCA---DSP 380
Query: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
C C N PG ++C C +GYRL+ +G C+D+DEC + C C N+ G F+C
Sbjct: 381 CCQQVCTNNPGGYECGC-YAGYRLSADGCGCEDVDECASSRGGC--EHHCTNLAGSFQC- 436
Query: 553 AFECPENYR 561
C YR
Sbjct: 437 --SCEAGYR 443
Score = 92.8 bits (229), Expect = 7e-19
Identities = 138/573 (24%), Positives = 192/573 (33%), Gaps = 136/573 (23%)
Query: 73 LEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMV 132
L C G LA + C ++ A + +C H CL QG S +
Sbjct: 265 LARCECHVGYQLAADGKAC-----EDVDECAAGLAQCAHGCL-----NTQG-SFKCVCHA 313
Query: 133 GYQCGQVFRAC------CVKSQETGD---------LDVGGLQETDKIIEVEEEQEDPYLN 177
GY+ G R C V S E + G L + E++ +Q
Sbjct: 314 GYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDV 373
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C C+Q C + C C+ GY+L +DG CEDV+EC + C C N
Sbjct: 374 DDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE--HHCTNLA 431
Query: 238 GSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GSF+C SC GY L ED C ++E + LP F+ R P +
Sbjct: 432 GSFQC----SCEAGYRLHEDRRGCSPLEEPMVDLDGELP-FV--------RPLPHI---- 474
Query: 297 GFIQDALGNCIDINECLSISAPCPI--GHT------CINTEGSYTCQKNVPNCGRGYHLN 348
+QD L ++ + + HT C++ + C +C G
Sbjct: 475 AVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNG---- 530
Query: 349 EEGTRCVDVDECAPP-----------AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397
GT + +D C P P G C SF C C+ G D ++ C
Sbjct: 531 --GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNC-----SFSCSCQNGGTCDSVTGAC 583
Query: 398 -----VDVNECQ-----RYPGRLCGHK--------CENTLGSYLCS-------CSVGFRL 432
V C+ Y G+ C K C G+ LC C +
Sbjct: 584 RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPP 643
Query: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQC-----------YCRRGY-------QLSDV 474
G C + +C P +Q C GS C C GY +
Sbjct: 644 WAFGPGCSEECQC-VQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCP 702
Query: 475 DGVTCEDID-ECA--LPTG--GHICSYRC----INIPGSFQCSCPS------SGYRLAPN 519
GV C+ + EC P G G C C + S CSC +G P
Sbjct: 703 VGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPP 762
Query: 520 GRNCQDID-ECVTGIHNCSINETCFNIQGGFRC 551
GR +D + +C G E C Q RC
Sbjct: 763 GRTGEDCEADCPEGRWGLGCQEICPACQHAARC 795
Score = 60.1 bits (144), Expect = 5e-09
Identities = 124/559 (22%), Positives = 175/559 (31%), Gaps = 120/559 (21%)
Query: 45 THQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEAT 104
T K+CS C C S C G+S N +D C P G
Sbjct: 559 TFGKNCSF-------SCSCQNGGTCDSVTGACRCPPGVSGTNCEDGC--PKG-------Y 602
Query: 105 FVKRC---CHCCLLGRAAQAQGQS-CEYSLMVGY------------------QCGQVFRA 142
+ K C C+C GR + G C+ L + QC Q
Sbjct: 603 YGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQ 662
Query: 143 CCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCF 202
C K + G + +RC+ C+ G C+C
Sbjct: 663 SCDKRDGSCSCKAG------------------FRGERCQA--ECELGYFGPGCWQACTCP 702
Query: 203 VGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF--RCQRDSSCGTG--YELTEDN 258
VG + D VS E C G G+ C VG+F C SCG + +T
Sbjct: 703 VG--VACDSVSGECGKRCPAGFQGEDCGQEC--PVGTFGVNCSSSCSCGGAPCHGVTGQC 758
Query: 259 SC------KDID-ECESGIHNCLPDFICQNTLGSFRCRPK---LQCKSGFIQDALGNCID 308
C +D + +C G IC + RC P+ C GF+ C D
Sbjct: 759 RCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVG---SRCQD 815
Query: 309 INECLSISAPCPIGHTCIN------TEGSYTCQKNVP--NCGRGYHLNEEGTRCVDVDEC 360
+ C +C N G +C +C R G C C
Sbjct: 816 VCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNC 875
Query: 361 APPAEPCGK-GHRCVNSPGSF--RCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
+ C C+ G RCE C G++ G + C +CQ G C
Sbjct: 876 SAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRC----QCQH------GAAC 925
Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCE------DINECSSSPCSQECANVYGSYQCYCRRGY 469
++ G+ C+C G+R + +C D + C V GS C C G
Sbjct: 926 DHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGS--CLCPAGR 981
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
+ G C + C T GH CS C G+ C AP + C
Sbjct: 982 R-----GPRC--AETCPAHTYGHNCSQACACFNGA-SCDPVHGQCHCAPGWMGPSCLQAC 1033
Query: 530 VTGIHNCSINETCFNIQGG 548
G++ + +C GG
Sbjct: 1034 PAGLYGDNCRHSCLCQNGG 1052
Score = 53.5 bits (127), Expect = 5e-07
Identities = 130/588 (22%), Positives = 167/588 (28%), Gaps = 149/588 (25%)
Query: 61 CRMVQEQCCHSQLEELHCA---TGISLANEQD------------RCATPHGDNASL---- 101
C + CH CA TG S D C+ HG ++
Sbjct: 830 CSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLC 889
Query: 102 --EATFV-KRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGL 158
EA +V RC C G Q C+ G C V AC + G
Sbjct: 890 LCEAGYVGPRCEQQCPQGHFGPGCEQRCQ--CQHGAACDHVSGACTCPAGWRGTF----- 942
Query: 159 QETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN 218
E + CR C C C G + G C +
Sbjct: 943 --------CEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRR----GPRCAETC 990
Query: 219 ECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH--NCLPD 276
T H+C +C N C G+ SC + C +G++ NC
Sbjct: 991 PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGW---MGPSC--LQACPAGLYGDNCRHS 1045
Query: 277 FICQN------TLGSFRCR---PKLQC-KSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
+CQN G C L C K +D C CL+ P C+
Sbjct: 1046 CLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCL 1105
Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC--------------GKGHR 372
G +T K C RG+ G C C PP C G G
Sbjct: 1106 CPAG-WTGDKCQSPCLRGWF----GEACAQRCSC-PPGAACHHVTGACRCPPGFTGSGCE 1159
Query: 373 CVNSPGSF----------------------RCECKTGYYFDGISRMCVDVN---ECQRYP 407
PGSF C C GY+ + C C++
Sbjct: 1160 QACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLC 1219
Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR 467
G L G C+ G+ C C GF G C C C +V C C +
Sbjct: 1220 GCLNGGSCDAATGA--CRCPTGFL----GTDCN--LTCPQGRFGPNCTHV-----CGCGQ 1266
Query: 468 GYQLSDVDGVTCEDIDECALPTG--GHICSYRC----INIPGSFQCSCPSSGYRLAPN-- 519
G V G C P G G C C + CSC + G A N
Sbjct: 1267 GAACDPVTGT-------CLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGS 1319
Query: 520 --------GRNCQDIDECVTGIH--------NCSINETCFNIQGGFRC 551
GR+C+ C G + +C N TC G RC
Sbjct: 1320 CSCGLGWTGRHCE--LACPPGRYGAACHLECSCHNNSTCEPATGTCRC 1365
Score = 52.8 bits (125), Expect = 9e-07
Identities = 107/483 (22%), Positives = 154/483 (31%), Gaps = 119/483 (24%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC--EDVNECITGSHSCRLGESCIN 235
D CR GG C C C G+ L +C + + + S SC+ G +C +
Sbjct: 525 DDCRNGGTCLLGLDG------CDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDS 578
Query: 236 TVGSFRC-------QRDSSCGTGY---ELTEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
G+ RC + C GY + +C + C CL D
Sbjct: 579 VTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCH 638
Query: 286 FRCRP--------------------------KLQCKSGFIQDALGNCIDIN----ECLSI 315
C P CK+GF + ++ C
Sbjct: 639 LTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQ- 697
Query: 316 SAPCPIGHTCINTEGSYTCQKNVP------NCGRGYHLNEEGTRCVDVDECAPPAEPC-G 368
+ CP+G C + G C K P +CG+ + G C C+ PC G
Sbjct: 698 ACTCPVGVACDSVSGE--CGKRCPAGFQGEDCGQECPVGTFGVNC--SSSCSCGGAPCHG 753
Query: 369 KGHRCVNSPG----SFRCECKTGYYFDGISRMC----------VDVNECQRYPGRLCGHK 414
+C PG +C G + G +C + C PG G +
Sbjct: 754 VTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPG-FVGSR 812
Query: 415 CENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSP------CSQECANVYG----SYQ 462
C++ G Y SC + DG CS +P C + C + S+
Sbjct: 813 CQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHP 872
Query: 463 CYCRRGYQLSDV-----------DGVTCEDIDECALPTGGHICSYRCINIPG------SF 505
C C G+ D G CE +C G C RC G S
Sbjct: 873 CNCSAGHGSCDAISGLCLCEAGYVGPRCE--QQCPQGHFGPGCEQRCQCQHGAACDHVSG 930
Query: 506 QCSCPSSGYR------LAPN---GRNCQDIDECVTGIHNCSINETCFNIQG--GFRCLAF 554
C+CP +G+R P G +C+ C G ++N +C G G RC A
Sbjct: 931 ACTCP-AGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRC-AE 988
Query: 555 ECP 557
CP
Sbjct: 989 TCP 991
Score = 48.1 bits (113), Expect = 2e-05
Identities = 102/422 (24%), Positives = 137/422 (32%), Gaps = 98/422 (23%)
Query: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS--HSCRLGESCINTV 237
C+ GG C C+C G+ G++CE EC+ CR C+N
Sbjct: 1048 CQNGGTCDPVSGH------CACPEGWA----GLACE--KECLPRDVRAGCRHSGGCLN-- 1093
Query: 238 GSFRCQRDSSCGTGYELTEDNSCKD------IDECESGIHNCLPDFICQNTLGSFRCRPK 291
G C T D C+ E + +C P C + G+ RC P
Sbjct: 1094 GGLCDPHTGRCLCPAGWTGDK-CQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPG 1152
Query: 292 LQ---CKSGFIQDALG-NCIDINECLSISAPC-PIGHTCINTEGSYTCQKNVPNCGRGYH 346
C+ + G +C + +C + C P TC +C GYH
Sbjct: 1153 FTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC--------------SCAAGYH 1198
Query: 347 LNEEGTRCVDVDECAPPAEP---CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
RC P E C G C + G+ C C TG+ + C
Sbjct: 1199 GPSCQQRC-PPGRYGPGCEQLCGCLNGGSCDAATGA--CRCPTGFLGTDCNLTCP----- 1250
Query: 404 QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRS---CEDINECSSSPCSQECANVYGS 460
Q G C H C G+ C G L GR+ CE C Q V
Sbjct: 1251 QGRFGPNCTHVCGCGQGA-ACDPVTGTCLCPPGRAGVRCE-------RGCPQNRFGVGCE 1302
Query: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF------QCSC----- 509
+ C CR G L +C C L G C C PG + +CSC
Sbjct: 1303 HTCSCRNG-GLCHASNGSC----SCGLGWTGRHCELAC--PPGRYGAACHLECSCHNNST 1355
Query: 510 --PSSG-YRLAPN--GRNCQDIDECVTGIHNCSINETCFNIQG------GFRCLAFECPE 558
P++G R P G+ C+ C G H C+ G RCL CP
Sbjct: 1356 CEPATGTCRCGPGFYGQACE--HPCPPGFHGAGCQGLCWCQHGAPCDPISGRCL---CPA 1410
Query: 559 NY 560
+
Sbjct: 1411 GF 1412
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 206 bits (524), Expect = 5e-53
Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
Query: 542 CFNIQGGFRCLAFECPENYR 561
C N + C EC E +R
Sbjct: 581 CVNSDDSYTC---ECLEGFR 597
Score = 194 bits (493), Expect = 2e-49
Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
Query: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
Query: 542 CFNIQGGFRCLAFECPENY 560
C N + C +C E +
Sbjct: 622 CVNNGNSYIC---KCSEGF 637
Score = 172 bits (435), Expect = 1e-42
Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)
Query: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
Query: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
Query: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
Query: 550 RCLAFECPENY 560
C +C E +
Sbjct: 466 VC---QCSEGF 473
Score = 161 bits (407), Expect = 2e-39
Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)
Query: 61 CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
C ++ C H + C G L ++Q C D ++E ++ C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
Query: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
C C G A G+ C + V Y C C E + D L + + +
Sbjct: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
Query: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
+++ D C C+ +C +T D C C G+ L D +C +N C
Sbjct: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
Query: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
C C+N S+ C+ C GY L + +C +D C H C + +C NT S
Sbjct: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
Query: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
F C QC GF I + L C ++ CL C ++C+N + S+ CQ C G
Sbjct: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
Query: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
+ L +G C +D CA C H CV+S SF C+C GY + C + CQ
Sbjct: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
Query: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
C H C N+ SY C C GFRL+ DG+ C + C S+ C C N SY
Sbjct: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
Query: 463 CYCRRGYQLSDVDGVTCEDIDE 484
C C G+ L++ DG C+ E
Sbjct: 631 CKCSEGFVLAE-DGRRCKKCTE 651
Score = 140 bits (353), Expect = 3e-33
Identities = 87/266 (32%), Positives = 122/266 (45%), Gaps = 27/266 (10%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C+ +C + + C C GY L +G +C V+ C H C + C+NT SF CQ
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
C G+ + ED +C +D C H C ++ C N SF C QC G + + G
Sbjct: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
Query: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C ++ C C H+C+++E S+ CQ C GY L E+G C D C
Sbjct: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C H CVNS S+ CEC G+ + C + C+ C H C N SY+
Sbjct: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKS-THHGCEHICVNNGNSYI 630
Query: 424 CSCSVGFRLSVDGRSCEDINECSSSP 449
C CS GF L+ DGR C+ +C+ P
Sbjct: 631 CKCSEGFVLAEDGRRCK---KCTEGP 653
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 206 bits (524), Expect = 5e-53
Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
Query: 542 CFNIQGGFRCLAFECPENYR 561
C N + C EC E +R
Sbjct: 581 CVNSDDSYTC---ECLEGFR 597
Score = 194 bits (493), Expect = 2e-49
Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
Query: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
Query: 542 CFNIQGGFRCLAFECPENY 560
C N + C +C E +
Sbjct: 622 CVNNGNSYIC---KCSEGF 637
Score = 172 bits (435), Expect = 1e-42
Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)
Query: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
Query: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
Query: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
Query: 550 RCLAFECPENY 560
C +C E +
Sbjct: 466 VC---QCSEGF 473
Score = 161 bits (407), Expect = 2e-39
Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)
Query: 61 CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
C ++ C H + C G L ++Q C D ++E ++ C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
Query: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
C C G A G+ C + V Y C C E + D L + + +
Sbjct: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
Query: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
+++ D C C+ +C +T D C C G+ L D +C +N C
Sbjct: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
Query: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
C C+N S+ C+ C GY L + +C +D C H C + +C NT S
Sbjct: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
Query: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
F C QC GF I + L C ++ CL C ++C+N + S+ CQ C G
Sbjct: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
Query: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
+ L +G C +D CA C H CV+S SF C+C GY + C + CQ
Sbjct: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
Query: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
C H C N+ SY C C GFRL+ DG+ C + C S+ C C N SY
Sbjct: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
Query: 463 CYCRRGYQLSDVDGVTCEDIDE 484
C C G+ L++ DG C+ E
Sbjct: 631 CKCSEGFVLAE-DGRRCKKCTE 651
Score = 140 bits (353), Expect = 3e-33
Identities = 87/266 (32%), Positives = 122/266 (45%), Gaps = 27/266 (10%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C+ +C + + C C GY L +G +C V+ C H C + C+NT SF CQ
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
C G+ + ED +C +D C H C ++ C N SF C QC G + + G
Sbjct: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
Query: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C ++ C C H+C+++E S+ CQ C GY L E+G C D C
Sbjct: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
C H CVNS S+ CEC G+ + C + C+ C H C N SY+
Sbjct: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKS-THHGCEHICVNNGNSYI 630
Query: 424 CSCSVGFRLSVDGRSCEDINECSSSP 449
C CS GF L+ DGR C+ +C+ P
Sbjct: 631 CKCSEGFVLAEDGRRCK---KCTEGP 653
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 204 bits (518), Expect = 2e-52
Identities = 126/352 (35%), Positives = 172/352 (48%), Gaps = 51/352 (14%)
Query: 243 QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
+ + C G+EL + C D DEC G C C N G F C C +GF
Sbjct: 3423 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 3473
Query: 302 ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
AL NC D++EC + C G C+N GSY C +P+CG G+ + +G C DV
Sbjct: 3474 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 3529
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DEC + C C N+PG RC C GY G S C+DVNEC + P + C ++C N
Sbjct: 3530 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 3588
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
GSY C C G L DG++C + + P + A++ G SY +
Sbjct: 3589 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3648
Query: 465 -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
R G LS V +GV C D+DEC + ++C + C N GS+QC CP
Sbjct: 3649 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 3704
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
+GYRL P+G+NCQDI+EC C + CFN +G ++C+ CP YR+
Sbjct: 3705 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQ 3755
Score = 182 bits (462), Expect = 7e-46
Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)
Query: 178 DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C GG PC C + C+C G+ L D +C DV+EC +H CR G+ C+N
Sbjct: 3445 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 3504
Query: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
+GS+RC D CG G+ + + C+D+DEC G+ +C + +C+NT G RC C
Sbjct: 3505 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 3558
Query: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ +Q C+D+NECL + C + C N +GSY C C G L +G C
Sbjct: 3559 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 3611
Query: 356 DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
++ P A G + S PG R C G+
Sbjct: 3612 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 3671
Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
+ +C D++EC+ LC H C NT GSY C C G+RL G++C+DINEC S
Sbjct: 3672 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 3727
Query: 449 PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
C Q C N GSYQC C Y+ G + G YR + +P
Sbjct: 3728 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 3786
Score = 157 bits (398), Expect = 2e-38
Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)
Query: 195 DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
+E C G++L S G C D +EC G C +C+N G F C +C TG+ L
Sbjct: 3422 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 3475
Query: 255 T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
+D +C+D+DEC H C C N LGS+RC P C GF + D G C D++EC
Sbjct: 3476 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 3532
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
L C C NT G + C +C RGY + C+DV+EC + C ++
Sbjct: 3533 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 3585
Query: 373 CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
C N GS+RC C G + C + PG
Sbjct: 3586 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 3644
Query: 413 HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
H + + SVG G C D++EC + C C N GSYQC C
Sbjct: 3645 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 3704
Query: 467 RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
GY+L G C+DI+EC + C N GS+QC CP++ YR P+ C
Sbjct: 3705 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 3762
Query: 524 --QDIDECVTG 532
+ +C TG
Sbjct: 3763 FRRCSQDCGTG 3773
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 204 bits (518), Expect = 2e-52
Identities = 126/352 (35%), Positives = 172/352 (48%), Gaps = 51/352 (14%)
Query: 243 QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
+ + C G+EL + C D DEC G C C N G F C C +GF
Sbjct: 4614 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 4664
Query: 302 ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
AL NC D++EC + C G C+N GSY C +P+CG G+ + +G C DV
Sbjct: 4665 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 4720
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DEC + C C N+PG RC C GY G S C+DVNEC + P + C ++C N
Sbjct: 4721 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 4779
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
GSY C C G L DG++C + + P + A++ G SY +
Sbjct: 4780 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 4839
Query: 465 -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
R G LS V +GV C D+DEC + ++C + C N GS+QC CP
Sbjct: 4840 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 4895
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
+GYRL P+G+NCQDI+EC C + CFN +G ++C+ CP YR+
Sbjct: 4896 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQ 4946
Score = 182 bits (462), Expect = 7e-46
Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)
Query: 178 DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C GG PC C + C+C G+ L D +C DV+EC +H CR G+ C+N
Sbjct: 4636 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 4695
Query: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
+GS+RC D CG G+ + + C+D+DEC G+ +C + +C+NT G RC C
Sbjct: 4696 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 4749
Query: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ +Q C+D+NECL + C + C N +GSY C C G L +G C
Sbjct: 4750 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 4802
Query: 356 DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
++ P A G + S PG R C G+
Sbjct: 4803 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 4862
Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
+ +C D++EC+ LC H C NT GSY C C G+RL G++C+DINEC S
Sbjct: 4863 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 4918
Query: 449 PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
C Q C N GSYQC C Y+ G + G YR + +P
Sbjct: 4919 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 4977
Score = 157 bits (398), Expect = 2e-38
Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)
Query: 195 DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
+E C G++L S G C D +EC G C +C+N G F C +C TG+ L
Sbjct: 4613 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 4666
Query: 255 T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
+D +C+D+DEC H C C N LGS+RC P C GF + D G C D++EC
Sbjct: 4667 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 4723
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
L C C NT G + C +C RGY + C+DV+EC + C ++
Sbjct: 4724 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 4776
Query: 373 CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
C N GS+RC C G + C + PG
Sbjct: 4777 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 4835
Query: 413 HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
H + + SVG G C D++EC + C C N GSYQC C
Sbjct: 4836 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 4895
Query: 467 RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
GY+L G C+DI+EC + C N GS+QC CP++ YR P+ C
Sbjct: 4896 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 4953
Query: 524 --QDIDECVTG 532
+ +C TG
Sbjct: 4954 FRRCSQDCGTG 4964
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 204 bits (518), Expect = 2e-52
Identities = 126/352 (35%), Positives = 172/352 (48%), Gaps = 51/352 (14%)
Query: 243 QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
+ + C G+EL + C D DEC G C C N G F C C +GF
Sbjct: 3332 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 3382
Query: 302 ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
AL NC D++EC + C G C+N GSY C +P+CG G+ + +G C DV
Sbjct: 3383 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 3438
Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
DEC + C C N+PG RC C GY G S C+DVNEC + P + C ++C N
Sbjct: 3439 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 3497
Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
GSY C C G L DG++C + + P + A++ G SY +
Sbjct: 3498 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3557
Query: 465 -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
R G LS V +GV C D+DEC + ++C + C N GS+QC CP
Sbjct: 3558 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 3613
Query: 511 SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
+GYRL P+G+NCQDI+EC C + CFN +G ++C+ CP YR+
Sbjct: 3614 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQ 3664
Score = 182 bits (462), Expect = 7e-46
Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)
Query: 178 DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C GG PC C + C+C G+ L D +C DV+EC +H CR G+ C+N
Sbjct: 3354 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 3413
Query: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
+GS+RC D CG G+ + + C+D+DEC G+ +C + +C+NT G RC C
Sbjct: 3414 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 3467
Query: 297 GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ +Q C+D+NECL + C + C N +GSY C C G L +G C
Sbjct: 3468 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 3520
Query: 356 DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
++ P A G + S PG R C G+
Sbjct: 3521 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 3580
Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
+ +C D++EC+ LC H C NT GSY C C G+RL G++C+DINEC S
Sbjct: 3581 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 3636
Query: 449 PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
C Q C N GSYQC C Y+ G + G YR + +P
Sbjct: 3637 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 3695
Score = 157 bits (398), Expect = 2e-38
Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)
Query: 195 DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
+E C G++L S G C D +EC G C +C+N G F C +C TG+ L
Sbjct: 3331 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 3384
Query: 255 T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
+D +C+D+DEC H C C N LGS+RC P C GF + D G C D++EC
Sbjct: 3385 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 3441
Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
L C C NT G + C +C RGY + C+DV+EC + C ++
Sbjct: 3442 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 3494
Query: 373 CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
C N GS+RC C G + C + PG
Sbjct: 3495 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 3553
Query: 413 HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
H + + SVG G C D++EC + C C N GSYQC C
Sbjct: 3554 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 3613
Query: 467 RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
GY+L G C+DI+EC + C N GS+QC CP++ YR P+ C
Sbjct: 3614 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 3671
Query: 524 --QDIDECVTG 532
+ +C TG
Sbjct: 3672 FRRCSQDCGTG 3682
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 202 bits (514), Expect = 7e-52
Identities = 121/344 (35%), Positives = 166/344 (48%), Gaps = 49/344 (14%)
Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
+ C GYE CKDIDEC+ C C N G + C PK Q
Sbjct: 27 TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
++ + G + S+ SA G ++ ++N
Sbjct: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
+P+ C GY +E C D+DEC C C+N GSF C+C GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
G CVD++EC P C +C NT GS+ C CS GF+L+ + +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC T ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318
Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
CP GY++ R CQDI+EC T + C +E C+N GGFRC
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRC 359
Score = 169 bits (428), Expect = 6e-42
Identities = 119/397 (29%), Positives = 173/397 (43%), Gaps = 73/397 (18%)
Query: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQI 77
Query: 243 --------------QRDSSCGTGYELTEDNSCKDI---------------DECESGIHNC 273
+ S TG + + E ++G +N
Sbjct: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN- 136
Query: 274 LPDFICQNTLGSFRCRP-----KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINT 328
F+ + + P ++QC +G+ Q C DI+EC + + C CIN
Sbjct: 137 ---FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINL 193
Query: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
GS+ CQ C GY + G +CVD+DEC P C + RCVN+PGSF C+C G+
Sbjct: 194 RGSFACQ-----CPPGY--QKRGEQCVDIDECTIPPY-CHQ--RCVNTPGSFYCQCSPGF 243
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--S 446
+ CVD+NEC C +C N LGS++C C+ G+ LS D +CEDI+EC S
Sbjct: 244 QLAANNYTCVDINECD--ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
S C +C N G + C C +GYQ+ V TC+DI+EC T C N G F+
Sbjct: 302 SYLCQYQCVNEPGKFSCMCPQGYQV--VRSRTCQDINECE-TTNECREDEMCWNYHGGFR 358
Query: 507 C---SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
C + Y L P R CV + N E
Sbjct: 359 CYPRNPCQDPYILTPENR-------CVCPVSNAMCRE 388
Score = 100 bits (248), Expect = 5e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
Score = 59.3 bits (142), Expect = 9e-09
Identities = 46/184 (25%), Positives = 72/184 (39%), Gaps = 52/184 (28%)
Query: 426 CSVGFRLSVDGRSCEDINECSSSPCS----QECANVYGSYQCYCRRGYQLSD-------- 473
C+ G+ + C+DI+EC P + +C N YG Y C + + +
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
Query: 474 -----VDGVTCEDIDECA------LPTGGHICSYRCI----------------------N 500
G T + + LP GG + S +
Sbjct: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
Query: 501 IPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPE 558
IP S + C ++GY + + CQDIDEC G HNC ++ C N++G F C +CP
Sbjct: 149 IPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFAC---QCPP 203
Query: 559 NYRR 562
Y++
Sbjct: 204 GYQK 207
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 202 bits (514), Expect = 7e-52
Identities = 121/344 (35%), Positives = 166/344 (48%), Gaps = 49/344 (14%)
Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
+ C GYE CKDIDEC+ C C N G + C PK Q
Sbjct: 27 TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
++ + G + S+ SA G ++ ++N
Sbjct: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
+P+ C GY +E C D+DEC C C+N GSF C+C GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
G CVD++EC P C +C NT GS+ C CS GF+L+ + +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC T ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318
Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
CP GY++ R CQDI+EC T + C +E C+N GGFRC
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRC 359
Score = 169 bits (428), Expect = 6e-42
Identities = 119/397 (29%), Positives = 173/397 (43%), Gaps = 73/397 (18%)
Query: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQI 77
Query: 243 --------------QRDSSCGTGYELTEDNSCKDI---------------DECESGIHNC 273
+ S TG + + E ++G +N
Sbjct: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN- 136
Query: 274 LPDFICQNTLGSFRCRP-----KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINT 328
F+ + + P ++QC +G+ Q C DI+EC + + C CIN
Sbjct: 137 ---FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINL 193
Query: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
GS+ CQ C GY + G +CVD+DEC P C + RCVN+PGSF C+C G+
Sbjct: 194 RGSFACQ-----CPPGY--QKRGEQCVDIDECTIPPY-CHQ--RCVNTPGSFYCQCSPGF 243
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--S 446
+ CVD+NEC C +C N LGS++C C+ G+ LS D +CEDI+EC S
Sbjct: 244 QLAANNYTCVDINECD--ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
S C +C N G + C C +GYQ+ V TC+DI+EC T C N G F+
Sbjct: 302 SYLCQYQCVNEPGKFSCMCPQGYQV--VRSRTCQDINECE-TTNECREDEMCWNYHGGFR 358
Query: 507 C---SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
C + Y L P R CV + N E
Sbjct: 359 CYPRNPCQDPYILTPENR-------CVCPVSNAMCRE 388
Score = 100 bits (248), Expect = 5e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
Score = 59.3 bits (142), Expect = 9e-09
Identities = 46/184 (25%), Positives = 72/184 (39%), Gaps = 52/184 (28%)
Query: 426 CSVGFRLSVDGRSCEDINECSSSPCS----QECANVYGSYQCYCRRGYQLSD-------- 473
C+ G+ + C+DI+EC P + +C N YG Y C + + +
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
Query: 474 -----VDGVTCEDIDECA------LPTGGHICSYRCI----------------------N 500
G T + + LP GG + S +
Sbjct: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
Query: 501 IPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPE 558
IP S + C ++GY + + CQDIDEC G HNC ++ C N++G F C +CP
Sbjct: 149 IPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFAC---QCPP 203
Query: 559 NYRR 562
Y++
Sbjct: 204 GYQK 207
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 202 bits (514), Expect = 7e-52
Identities = 121/344 (35%), Positives = 166/344 (48%), Gaps = 49/344 (14%)
Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
+ C GYE CKDIDEC+ C C N G + C PK Q
Sbjct: 27 TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
++ + G + S+ SA G ++ ++N
Sbjct: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
+P+ C GY +E C D+DEC C C+N GSF C+C GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
G CVD++EC P C +C NT GS+ C CS GF+L+ + +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC T ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318
Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
CP GY++ R CQDI+EC T + C +E C+N GGFRC
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRC 359
Score = 169 bits (428), Expect = 6e-42
Identities = 119/397 (29%), Positives = 173/397 (43%), Gaps = 73/397 (18%)
Query: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQI 77
Query: 243 --------------QRDSSCGTGYELTEDNSCKDI---------------DECESGIHNC 273
+ S TG + + E ++G +N
Sbjct: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN- 136
Query: 274 LPDFICQNTLGSFRCRP-----KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINT 328
F+ + + P ++QC +G+ Q C DI+EC + + C CIN
Sbjct: 137 ---FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINL 193
Query: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
GS+ CQ C GY + G +CVD+DEC P C + RCVN+PGSF C+C G+
Sbjct: 194 RGSFACQ-----CPPGY--QKRGEQCVDIDECTIPPY-CHQ--RCVNTPGSFYCQCSPGF 243
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--S 446
+ CVD+NEC C +C N LGS++C C+ G+ LS D +CEDI+EC S
Sbjct: 244 QLAANNYTCVDINECD--ASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
S C +C N G + C C +GYQ+ V TC+DI+EC T C N G F+
Sbjct: 302 SYLCQYQCVNEPGKFSCMCPQGYQV--VRSRTCQDINECE-TTNECREDEMCWNYHGGFR 358
Query: 507 C---SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
C + Y L P R CV + N E
Sbjct: 359 CYPRNPCQDPYILTPENR-------CVCPVSNAMCRE 388
Score = 100 bits (248), Expect = 5e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
Score = 59.3 bits (142), Expect = 9e-09
Identities = 46/184 (25%), Positives = 72/184 (39%), Gaps = 52/184 (28%)
Query: 426 CSVGFRLSVDGRSCEDINECSSSPCS----QECANVYGSYQCYCRRGYQLSD-------- 473
C+ G+ + C+DI+EC P + +C N YG Y C + + +
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
Query: 474 -----VDGVTCEDIDECA------LPTGGHICSYRCI----------------------N 500
G T + + LP GG + S +
Sbjct: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
Query: 501 IPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPE 558
IP S + C ++GY + + CQDIDEC G HNC ++ C N++G F C +CP
Sbjct: 149 IPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFAC---QCPP 203
Query: 559 NYRR 562
Y++
Sbjct: 204 GYQK 207
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 200 bits (508), Expect = 3e-51
Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)
Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274
+ +EC + C GE C+ + C C GY + C D++ECE+ C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
Query: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330
P IC NT GS+ C C G+ + +C+D+NEC C G CIN G
Sbjct: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
Query: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388
Y C NC GY L C D+DEC P+ C G +C N PGSF+C C+ GY
Sbjct: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
G C DVNEC G C CEN GS+ C+C+ G+ + DGRSC D++EC +
Sbjct: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
Query: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502
C+N GS+QC C GY LS D CEDIDEC P GG CIN
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
Query: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
GS++C CP G+RL GR CQDIDEC C + C N+QG + C+ E
Sbjct: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
Score = 185 bits (469), Expect = 1e-46
Identities = 140/416 (33%), Positives = 188/416 (45%), Gaps = 57/416 (13%)
Query: 170 EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
E ++ LN G G C D C C GY+ C DVNEC + C
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYS----CHCNPGYRSHPQHRYCVDVNEC--EAEPCGP 627
Query: 230 GES-CINTVGSFRCQRDSSCGTGYEL---TEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
G C+NT GS+ C C GY L SC D++EC H C C N G
Sbjct: 628 GRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFPGH 682
Query: 286 FRCRPKLQCKSGFIQDALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
++C C G+ A C DI+EC S+ CP G C N GS+ C C
Sbjct: 683 YKC----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIA----CQP 732
Query: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
GY ++ G C DV+ECA PC G C N PGSFRC C GY R C+DV+EC
Sbjct: 733 GYR-SQGGGACRDVNECA-EGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789
Query: 404 QRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGS 460
+ G +C + C NT GS+ C C G+ LS D CEDI+EC ++ +C N GS
Sbjct: 790 E--AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847
Query: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Y+C C +G++L V G C+DIDEC+ + C N+ GS+ C C G+ +
Sbjct: 848 YRCLCPQGHRL--VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQ 904
Query: 521 RNCQDID------ECVTGIH-----------NCSINETCFNIQGGF--RCLAFECP 557
C++++ EC N + E C ++ G+ C + CP
Sbjct: 905 HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
Score = 144 bits (363), Expect = 2e-34
Identities = 122/397 (30%), Positives = 160/397 (40%), Gaps = 70/397 (17%)
Query: 178 DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
+ C G PC C + C+C GY DG SC DV+EC G C G C NT
Sbjct: 746 NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
Query: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
GSF+CQ C +GY L+ D S C+DIDEC+ D C NT GS+RC C
Sbjct: 804 PGSFQCQ----CLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINTNGSYRCL----CP 853
Query: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G C DI+EC + C C N +GSY C C G+ ++ C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV-----CDEGFTPTQDQHGCE 908
Query: 356 DVD------EC-----------------APPAEPC-----GKGHRC------VNSPGSFR 381
+V+ EC E C G G C V S F
Sbjct: 909 EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968
Query: 382 CECKTGYYFDGISRMCV-------DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLS 433
C G + + + D++EC + +C KC NT Y C C GF
Sbjct: 969 SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028
Query: 434 VDGRSCEDINEC-SSSPCSQE-CANVYGSYQCYCRRGYQLSDVDGVTCE----DIDECAL 487
+ C D++EC S C C N G Y+C C + S D+DEC
Sbjct: 1029 GNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD 1088
Query: 488 PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524
P RC+N+PGS++C C + P+GR+CQ
Sbjct: 1089 PAACR--PGRCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122
Score = 117 bits (293), Expect = 3e-26
Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)
Query: 163 KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218
K +++E +DP L C G CK + VC C G+ D CE+V
Sbjct: 863 KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
Query: 219 --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252
EC C LG + + C SS C G
Sbjct: 916 KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
Query: 253 ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303
T+DN+ +DIDEC + C NT + C CK GF D L
Sbjct: 976 GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
C+D++ECL S C G C NT G Y C P +DVDEC P
Sbjct: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089
Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410
A C G RCVN PGS+RCEC+ + R C DV QR +
Sbjct: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147
Query: 411 C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469
C G L C C G R C S P SQ +N + G
Sbjct: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206
Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
D D ED DEC +G RC+ PG C CP G++L + C DIDEC
Sbjct: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258
Query: 530 --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563
+ +E C N G FRC+ C + RS
Sbjct: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291
Score = 82.4 bits (202), Expect = 1e-15
Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)
Query: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93
C GHR+ +K + ++ + C + Q + C G + +Q C
Sbjct: 852 CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911
Query: 94 -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140
PH S+ AT V + CC LG G CE Y +
Sbjct: 912 QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968
Query: 141 RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199
C D G + + I+ G CK+ +C +T C
Sbjct: 969 SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019
Query: 200 SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258
C G+ + + C DV+EC+ S+ CR G C NT G +RC +C E +
Sbjct: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073
Query: 259 SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290
C D+DEC+ C P C N GS+RC RP
Sbjct: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131
Query: 291 ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330
+ C S +D + G + ++C PCP G C ++
Sbjct: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
+ G +E + D DEC C G RCV PG CEC G+
Sbjct: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245
Query: 391 DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439
D CVD++EC+ G LC +C NT GS+ C C GF S +C
Sbjct: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
Score = 80.9 bits (198), Expect = 3e-15
Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)
Query: 216 DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271
D++EC+ GS C+ G+ C+NT + C C G+ + C D+DEC ES
Sbjct: 993 DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
Query: 272 NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329
N +C+NT G +RC P + Q +D++EC +A C G C+N
Sbjct: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101
Query: 330 GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359
GSY C+ P GR L E E C + D+
Sbjct: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
Query: 360 CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408
C P P G G C S T G D +E
Sbjct: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
Query: 409 RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462
R +C G +C C GF+L C DI+EC C S+ C N GS++
Sbjct: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
Query: 463 CYCRRGYQLSDVDG 476
C C+ G+ S G
Sbjct: 1282 CVCKAGFARSRPHG 1295
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)
Query: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
+C +GY LN T C D++ECA P C G C+N+PGS+RC C G+ C+
Sbjct: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
Query: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
+ + C R P C H L LC CSVG
Sbjct: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)
Query: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510
Q+ V G C +GY+ ++ C+DI+ECA+P +C + C+N PGS++C CP
Sbjct: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
Query: 511 SSGYRLAPNGRNC 523
G+ L P+ C
Sbjct: 383 -PGHSLGPSRTQC 394
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/103 (30%), Positives = 44/103 (42%), Gaps = 18/103 (17%)
Query: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-LGNCIDINECLS 314
ED+S +D DEC C+P G C +C GF DA C+DI+EC
Sbjct: 1211 EDSSEEDSDECRCVSGRCVP------RPGGAVC----ECPGGFQLDASRARCVDIDECRE 1260
Query: 315 ISAPCPI--GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
++ + C+NT GS+ C C G+ + CV
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCV-----CKAGFARSRPHGACV 1298
Score = 37.4 bits (85), Expect = 0.037
Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416
K H+C V PG R E C GY S C D+NEC PG +C H C
Sbjct: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
Query: 417 NTLGSYLCSCSVGFRLSVDGRSC 439
N GSY C C G L C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
Score = 36.2 bits (82), Expect = 0.082
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
G C G++ ++ C+DINEC+ + +C N GSY+C C G+ L
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)
Query: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
G R C G+ + +C DINEC ++ C G C+N GSY C C
Sbjct: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
Query: 344 GYHLNEEGTRCV 355
G+ L T+C+
Sbjct: 384 GHSLGPSRTQCI 395
Score = 32.7 bits (73), Expect = 0.91
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)
Query: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
+ G CP RL N +CQDI+EC + + C N G +RC+ CP +
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)
Query: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
H C +L + + G R + + C GY+ C+DI+EC + C N
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
Query: 284 GSFRC 288
GS+RC
Sbjct: 375 GSYRC 379
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 200 bits (508), Expect = 3e-51
Identities = 136/353 (38%), Positives = 173/353 (49%), Gaps = 43/353 (12%)
Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274
+ +EC + C GE C+ + C C GY + C D++ECE+ C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626
Query: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330
P IC NT GS+ C C G+ + +C+D+NEC C G CIN G
Sbjct: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681
Query: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388
Y C NC GY L C D+DEC P+ C G +C N PGSF+C C+ GY
Sbjct: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734
Query: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
G C DVNEC G C CEN GS+ C+C+ G+ + DGRSC D++EC +
Sbjct: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791
Query: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502
C+N GS+QC C GY LS D CEDIDEC P GG CIN
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845
Query: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
GS++C CP G+RL GR CQDIDEC C + C N+QG + C+ E
Sbjct: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896
Score = 185 bits (469), Expect = 1e-46
Identities = 140/416 (33%), Positives = 188/416 (45%), Gaps = 57/416 (13%)
Query: 170 EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
E ++ LN G G C D C C GY+ C DVNEC + C
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYS----CHCNPGYRSHPQHRYCVDVNEC--EAEPCGP 627
Query: 230 GES-CINTVGSFRCQRDSSCGTGYEL---TEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
G C+NT GS+ C C GY L SC D++EC H C C N G
Sbjct: 628 GRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFPGH 682
Query: 286 FRCRPKLQCKSGFIQDALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
++C C G+ A C DI+EC S+ CP G C N GS+ C C
Sbjct: 683 YKC----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIA----CQP 732
Query: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
GY ++ G C DV+ECA PC G C N PGSFRC C GY R C+DV+EC
Sbjct: 733 GYR-SQGGGACRDVNECA-EGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789
Query: 404 QRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGS 460
+ G +C + C NT GS+ C C G+ LS D CEDI+EC ++ +C N GS
Sbjct: 790 E--AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847
Query: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Y+C C +G++L V G C+DIDEC+ + C N+ GS+ C C G+ +
Sbjct: 848 YRCLCPQGHRL--VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQ 904
Query: 521 RNCQDID------ECVTGIH-----------NCSINETCFNIQGGF--RCLAFECP 557
C++++ EC N + E C ++ G+ C + CP
Sbjct: 905 HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960
Score = 154 bits (388), Expect = 3e-37
Identities = 137/488 (28%), Positives = 182/488 (37%), Gaps = 132/488 (27%)
Query: 178 DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
D C G C C +T C C GY L D CED++EC + +C +G CINT
Sbjct: 787 DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844
Query: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
GS+RC C G+ L C+DIDEC CLP C+N GS+ C C
Sbjct: 845 NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896
Query: 297 GFI--QDALGNCIDINE------------------------------CLSISA------- 317
GF QD G C ++ + C S+ A
Sbjct: 897 GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
Query: 318 --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
PCP+ H+ YT N+ N G H D+DEC K
Sbjct: 956 IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007
Query: 371 HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430
+CVN+ + C CK G+Y+DG CVDV+EC G CENT G Y C+C+
Sbjct: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066
Query: 431 RLSVDGRSCEDINECSSSP---------------CSQECANVYGSY-QCYCRRG------ 468
S R C E +P C+ A ++ C CR+G
Sbjct: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126
Query: 469 -----------------------YQLSDV--------DGVTCEDIDECALPTGGHICSYR 497
+ S + + + ED DEC +G R
Sbjct: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG------R 1180
Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFE 555
C+ PG C CP G++L + C DIDEC + +E C N G FRC+
Sbjct: 1181 CVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236
Query: 556 CPENYRRS 563
C + RS
Sbjct: 1237 CKAGFARS 1244
Score = 119 bits (298), Expect = 7e-27
Identities = 103/334 (30%), Positives = 133/334 (39%), Gaps = 63/334 (18%)
Query: 178 DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
+ C G PC C + C+C GY DG SC DV+EC G C G C NT
Sbjct: 746 NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803
Query: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
GSF+CQ C +GY L+ D S C+DIDEC+ D C NT GS+RC C
Sbjct: 804 PGSFQCQ----CLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINTNGSYRC----LCP 853
Query: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
G C DI+EC + C C N +GSY C C G+ ++ C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV-----CDEGFTPTQDQHGCE 908
Query: 356 DVD------EC-----------------APPAEPC-----GKGHRC------VNSPGSFR 381
+V+ EC E C G G C V S F
Sbjct: 909 EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968
Query: 382 CECKTGYYFDGISRMC-------VDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLS 433
C G + + + D++EC + +C KC NT Y C C GF
Sbjct: 969 SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028
Query: 434 VDGRSCEDINEC-SSSPC-SQECANVYGSYQCYC 465
+ C D++EC S C + C N G Y+C C
Sbjct: 1029 GNLLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062
Score = 79.0 bits (193), Expect = 1e-14
Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)
Query: 216 DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271
D++EC+ GS C+ G+ C+NT + C C G+ + C D+DEC ES
Sbjct: 993 DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047
Query: 272 NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301
N +C+NT G +RC + QC S G
Sbjct: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103
Query: 302 AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
L G + ++C PCP G C ++ + G +
Sbjct: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163
Query: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407
E + D DEC C G RCV PG CEC G+ D CVD++EC+
Sbjct: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
Query: 408 GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439
G LC +C NT GS+ C C GF S +C
Sbjct: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 77.4 bits (189), Expect = 3e-14
Identities = 98/399 (24%), Positives = 128/399 (32%), Gaps = 98/399 (24%)
Query: 163 KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218
K +++E +DP L C G CK + VC C G+ D CE+V
Sbjct: 863 KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915
Query: 219 --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252
EC C LG + + C SS C G
Sbjct: 916 KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975
Query: 253 ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303
T+DN+ +DIDEC + C NT + C CK GF D L
Sbjct: 976 GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031
Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP--------NCGRGYHLNEEGTR-- 353
C+D++ECL S C G C NT G Y C P C + R
Sbjct: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD 1089
Query: 354 -------------------CVDVDECA-----------PPAEPCGKGHRCVNSPGSFRCE 383
+ D+C P P G G C S
Sbjct: 1090 VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSF 1149
Query: 384 CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
T G D +E R +C G +C C GF+L C DI+
Sbjct: 1150 WDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDID 1209
Query: 444 ECSSSP-----C-SQECANVYGSYQCYCRRGYQLSDVDG 476
EC C S+ C N GS++C C+ G+ S G
Sbjct: 1210 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)
Query: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
+C +GY LN T C D++ECA P C G C+N+PGS+RC C G+ C+
Sbjct: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395
Query: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
+ + C R P C H L LC CSVG
Sbjct: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)
Query: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510
Q+ V G C +GY+ ++ C+DI+ECA+P +C + C+N PGS++C CP
Sbjct: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382
Query: 511 SSGYRLAPNGRNC 523
G+ L P+ C
Sbjct: 383 -PGHSLGPSRTQC 394
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/103 (30%), Positives = 44/103 (42%), Gaps = 18/103 (17%)
Query: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-LGNCIDINECLS 314
ED+S +D DEC C+P G C +C GF DA C+DI+EC
Sbjct: 1164 EDSSEEDSDECRCVSGRCVP------RPGGAVC----ECPGGFQLDASRARCVDIDECRE 1213
Query: 315 ISAPCPI--GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
++ + C+NT GS+ C C G+ + CV
Sbjct: 1214 LNQRGLLCKSERCVNTSGSFRCV-----CKAGFARSRPHGACV 1251
Score = 37.4 bits (85), Expect = 0.037
Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416
K H+C V PG R E C GY S C D+NEC PG +C H C
Sbjct: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371
Query: 417 NTLGSYLCSCSVGFRLSVDGRSC 439
N GSY C C G L C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQC 394
Score = 36.2 bits (82), Expect = 0.082
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
G C G++ ++ C+DINEC+ + +C N GSY+C C G+ L
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)
Query: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
G R C G+ + +C DINEC ++ C G C+N GSY C C
Sbjct: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383
Query: 344 GYHLNEEGTRCV 355
G+ L T+C+
Sbjct: 384 GHSLGPSRTQCI 395
Score = 32.7 bits (73), Expect = 0.91
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 7/60 (11%)
Query: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
+ G CP RL N +CQDI+EC + + C N G +RC+ CP +
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)
Query: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
H C +L + + G R + + C GY+ C+DI+EC + C N
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374
Query: 284 GSFRC 288
GS+RC
Sbjct: 375 GSYRC 379
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 197 bits (500), Expect = 3e-50
Identities = 130/385 (33%), Positives = 187/385 (48%), Gaps = 41/385 (10%)
Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
C C + C+C+ G+ L DG +C DV+EC G+ C+ +SC+N +GS+ C
Sbjct: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137
Query: 246 SSCGTGYELTEDNSCKDIDECESGIHNCLPD-----FICQNT-LGSFRCRPKLQCKSGFI 299
C G+ L+ DN I E G+ NC+ IC+ T G C +C+ GF
Sbjct: 138 --CREGFFLS-DNQHTCIQRPEEGM-NCMNKNHGCAHICRETPKGGIAC----ECRPGF- 188
Query: 300 QDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVD 358
+ N D C + C HTC +TE C C + L+ +G C++
Sbjct: 189 -ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET- 239
Query: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT 418
CA C +C ++ C C G+ + C D++EC+ G C H C NT
Sbjct: 240 -CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRNT 295
Query: 419 LGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDGV 477
+GS+ CSC G++L ++ R+C+DI+ECS C C N GS+QC C RGY L G+
Sbjct: 296 VGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---GI 352
Query: 478 T-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536
T C D+DEC++ GG C + CIN PGS+QC+CP+ RL NG++C + +C G
Sbjct: 353 THCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPGA 409
Query: 537 SINETCFNIQGGFRCLAFECPENYR 561
S N G A CP R
Sbjct: 410 SKAMLSCNRSGKKDTCALTCPSRAR 434
Score = 188 bits (478), Expect = 1e-47
Identities = 118/347 (34%), Positives = 167/347 (48%), Gaps = 37/347 (10%)
Query: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
+ +DV+EC+ G+ +C + C NT S++C C +GY + CKD+DECE +
Sbjct: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80
Query: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
C+ D C N G++RC C GF G NC+D++EC + C +C+N G
Sbjct: 81 GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132
Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
SY C +C G+ L++ C+ E C C H C +P G CEC+
Sbjct: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185
Query: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
G+ R C Y C H C++T C C + F L DG++C +
Sbjct: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
Query: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
++ C +C + C C G+ L D TC+DIDEC L GG C + C N GSF
Sbjct: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299
Query: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
+CSC GY+L N RNCQDIDEC + + + C N G F+CL
Sbjct: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL 342
Score = 112 bits (279), Expect = 1e-24
Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)
Query: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
C DG +A +C + EC C S + E HC G L++ Q C
Sbjct: 97 CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151
Query: 92 ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
+ + C H C R G +CE G++ + R C + T
Sbjct: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201
Query: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
+ GG Q T E V + G C +C D V C+
Sbjct: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261
Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
C VG+ L D +C+D++EC + C C NTVGSF C SC GY+ L + +
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315
Query: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
C+DIDEC S C D IC NT GSF+C C G++ + +C D++EC C
Sbjct: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368
Query: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
G CINT GSY C C G L+ G C + +C
Sbjct: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)
Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
R A + QD+DECV G NC I+ C N ++C+ C Y
Sbjct: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGY 61
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.463
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,860,044
Number of Sequences: 37866
Number of extensions: 1500154
Number of successful extensions: 10526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 3107
Number of HSP's gapped (non-prelim): 1842
length of query: 566
length of database: 18,247,518
effective HSP length: 108
effective length of query: 458
effective length of database: 14,157,990
effective search space: 6484359420
effective search space used: 6484359420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.