Guide to the Human Genome
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Search of human proteins with 34734062

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
         (683 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]             1469   0.0  
gi|34734066 fibulin 1 isoform D [Homo sapiens]                       1240   0.0  
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]             1235   0.0  
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]             1234   0.0  
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              645   0.0  
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              623   e-178
gi|118572606 hemicentin 1 [Homo sapiens]                              276   6e-74
gi|19743803 fibulin 5 precursor [Homo sapiens]                        272   7e-73
gi|46249414 latent transforming growth factor beta binding prote...   256   4e-68
gi|46249412 latent transforming growth factor beta binding prote...   256   4e-68
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      250   3e-66
gi|86788132 EGF-containing fibulin-like extracellular matrix pro...   241   2e-63
gi|86788015 EGF-containing fibulin-like extracellular matrix pro...   241   2e-63
gi|9665262 EGF-containing fibulin-like extracellular matrix prot...   241   2e-63
gi|110347437 latent transforming growth factor beta binding prot...   239   5e-63
gi|110347412 latent transforming growth factor beta binding prot...   239   5e-63
gi|110347431 latent transforming growth factor beta binding prot...   239   5e-63
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      235   9e-62
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      234   3e-61
gi|4557733 latent transforming growth factor beta binding protei...   228   2e-59
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               215   9e-56
gi|190343004 EGF-containing fibulin-like extracellular matrix pr...   215   1e-55
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   213   4e-55
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   213   4e-55
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   213   4e-55
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             207   2e-53
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             207   2e-53
gi|194328809 latent transforming growth factor beta binding prot...   202   1e-51
gi|18497288 latent transforming growth factor beta binding prote...   202   1e-51
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     197   3e-50

>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score = 1469 bits (3802), Expect = 0.0
 Identities = 683/683 (100%), Positives = 683/683 (100%)

Query: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
           MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60

Query: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
           CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120

Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
           AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180

Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
           RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240

Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
           RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300

Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
           DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360

Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
           APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420

Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
           SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
           DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540

Query: 541 TCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP 600
           TCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP 600

Query: 601 AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM 660
           AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM
Sbjct: 601 AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM 660

Query: 661 DLSRHGTVSSFVAKLFIFVSAEL 683
           DLSRHGTVSSFVAKLFIFVSAEL
Sbjct: 661 DLSRHGTVSSFVAKLFIFVSAEL 683


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 597/699 (85%), Positives = 615/699 (87%), Gaps = 19/699 (2%)

Query: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
           MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60

Query: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
           CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120

Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
           AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180

Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
           RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240

Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
           RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300

Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
           DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360

Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
           APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420

Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
           SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
           DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540

Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT---------RCERLPCHENRECSKLPLR-ITYYH 590
           TCFNIQGGFRCLAFECPENYRRSAAT         RC +     +  C   P+  I++  
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV 600

Query: 591 LSFPT---NIQAPAVVFRMGPSSAVPGDSMQLA--ITGGNEEGFFTTRKVSPHS---GVV 642
           +S PT     +   ++F    +   P     +   IT GN    F   K        GVV
Sbjct: 601 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV 660

Query: 643 ALTKPVPEPRDLLLTVKMDLSRHGTVS-SFVAKLFIFVS 680
              +P+  P   +L ++M+    G VS   V  + IFVS
Sbjct: 661 RQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVS 699


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score = 1235 bits (3195), Expect = 0.0
 Identities = 566/567 (99%), Positives = 567/567 (100%)

Query: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
           MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60

Query: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
           CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120

Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
           AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180

Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
           RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240

Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
           RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300

Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
           DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360

Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
           APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420

Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
           SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
           DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540

Query: 541 TCFNIQGGFRCLAFECPENYRRSAATR 567
           TCFNIQGGFRCLAFECPENYRRSAAT+
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAATQ 567


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score = 1234 bits (3194), Expect = 0.0
 Identities = 566/566 (100%), Positives = 566/566 (100%)

Query: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60
           MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
Sbjct: 1   MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE 60

Query: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120
           CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
Sbjct: 61  CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ 120

Query: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180
           AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
Sbjct: 121 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC 180

Query: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240
           RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
Sbjct: 181 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF 240

Query: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
           RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
Sbjct: 241 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300

Query: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
           DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
Sbjct: 301 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360

Query: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420
           APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG 420

Query: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
           SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
Sbjct: 421 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
           DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540

Query: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566
           TCFNIQGGFRCLAFECPENYRRSAAT
Sbjct: 541 TCFNIQGGFRCLAFECPENYRRSAAT 566


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  645 bits (1665), Expect = 0.0
 Identities = 280/499 (56%), Positives = 359/499 (71%), Gaps = 3/499 (0%)

Query: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
            C+  GPCKQ C   G   +CSCF GY +++DGVSCED+NEC+T  H+C  GE C+NT+GS
Sbjct: 683  CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGS 742

Query: 240  FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
            F C +  +C  GY L +D  C+D+DEC  G H C P F+CQNT GSF C+ + +C  GF+
Sbjct: 743  FHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 801

Query: 300  QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE 359
            QD  GNC+DINEC S+S PC  G +CINT GSYTCQ+N   C RGYH +++GT+CVDV+E
Sbjct: 802  QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNE 861

Query: 360  CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
            C      CG+G  C N PGS+RC+CK G+  D   R C+DVNEC   PGRLC H CENTL
Sbjct: 862  CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTL 921

Query: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
            GSY CSC+ GF L+ DG+ CED+NEC +  CSQECAN+YGSYQCYCR+GYQL++ DG TC
Sbjct: 922  GSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DGHTC 980

Query: 480  EDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
             DIDECA    G +C++RC+N+PGS+QC+CP  GY +  NGR+C+D+DEC  G HNCS  
Sbjct: 981  TDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1039

Query: 540  ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQA 599
            ETC NIQG FRCL FECP NY + + T+CER  CH+  EC   P RIT+Y L+F T +  
Sbjct: 1040 ETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLV 1099

Query: 600  PAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVK 659
            PA +FR+GP+ A  GD++ L I  GNEEG+F TR+++ ++GVV L + V EPRD  L V+
Sbjct: 1100 PAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVE 1159

Query: 660  MDLSRHGTVSSFVAKLFIF 678
            M L R G+V++F+AK+ IF
Sbjct: 1160 MKLWRQGSVTTFLAKMHIF 1178



 Score =  122 bits (305), Expect = 1e-27
 Identities = 119/403 (29%), Positives = 159/403 (39%), Gaps = 79/403 (19%)

Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ---C 294
           GS +   ++ C  G +   DN     DEC     +   D +C+ T     C   LQ   C
Sbjct: 436 GSTKDLIETCCAAGQQWAIDN-----DECLEIPESGTEDNVCR-TAQRHCCVSYLQEKSC 489

Query: 295 KSGFIQDALGNCI--DINECLSISAPCPIGHTC-----INTEGSYTCQKNVPNCGRGYHL 347
            +G +    G     + N+   IS        C     +  EG  +C+ N PN G  Y  
Sbjct: 490 MAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ-SCESN-PNLG--YPC 545

Query: 348 NE------EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-V 400
           N       EG   + V E   P EP     R   +  + R     G   +  + +  D  
Sbjct: 546 NHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQ 605

Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE-------------------- 440
           +EC   PG LC H C NT+GSY C+C  GF L  DGR+C                     
Sbjct: 606 DECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665

Query: 441 -------------DINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
                          N C  + PC Q C+ V GS  C C  GY +   DGV+CEDI+EC 
Sbjct: 666 SQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM-ADGVSCEDINECV 724

Query: 487 LPTGGHICS--YRCINIPGSFQC----SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
             T  H CS    C+N  GSF C    +C   GY L      C+D+DEC  G H C    
Sbjct: 725 --TDLHTCSRGEHCVNTLGSFHCYKALTC-EPGYALKDG--ECEDVDECAMGTHTCQPGF 779

Query: 541 TCFNIQGGFRCLAFE-CPENYRRSAATRCERLPCHENRECSKL 582
            C N +G F C A + C + + +     C  +      EC+ L
Sbjct: 780 LCQNTKGSFYCQARQRCMDGFLQDPEGNCVDI-----NECTSL 817


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  623 bits (1607), Expect = e-178
 Identities = 280/546 (51%), Positives = 359/546 (65%), Gaps = 50/546 (9%)

Query: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED----------------------- 216
            C+  GPCKQ C   G   +CSCF GY +++DGVSCED                       
Sbjct: 683  CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGS 742

Query: 217  ------------------------VNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY 252
                                    +NEC+T  H+C  GE C+NT+GSF C +  +C  GY
Sbjct: 743  FYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802

Query: 253  ELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC 312
             L +D  C+D+DEC  G H C P F+CQNT GSF C+ + +C  GF+QD  GNC+DINEC
Sbjct: 803  AL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINEC 861

Query: 313  LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
             S+S PC  G +CINT GSYTCQ+N   C RGYH +++GT+CVDV+EC      CG+G  
Sbjct: 862  TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 921

Query: 373  CVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL 432
            C N PGS+RC+CK G+  D   R C+DVNEC   PGRLC H CENTLGSY CSC+ GF L
Sbjct: 922  CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL 981

Query: 433  SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
            + DG+ CED+NEC +  CSQECAN+YGSYQCYCR+GYQL++ DG TC DIDECA    G 
Sbjct: 982  AADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DGHTCTDIDECA-QGAGI 1039

Query: 493  ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
            +C++RC+N+PGS+QC+CP  GY +  NGR+C+D+DEC  G HNCS  ETC NIQG FRCL
Sbjct: 1040 LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1099

Query: 553  AFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAV 612
             FECP NY + + T+CER  CH+  EC   P RIT+Y L+F T +  PA +FR+GP+ A 
Sbjct: 1100 RFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAF 1159

Query: 613  PGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV 672
             GD++ L I  GNEEG+F TR+++ ++GVV L + V EPRD  L V+M L R G+V++F+
Sbjct: 1160 TGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEMKLWRQGSVTTFL 1219

Query: 673  AKLFIF 678
            AK+ IF
Sbjct: 1220 AKMHIF 1225



 Score =  128 bits (322), Expect = 2e-29
 Identities = 120/381 (31%), Positives = 154/381 (40%), Gaps = 72/381 (18%)

Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ---C 294
           GS +   ++ C  G +   DN     DEC     +   D +C+ T     C   LQ   C
Sbjct: 436 GSTKDLIETCCAAGQQWAIDN-----DECLEIPESGTEDNVCR-TAQRHCCVSYLQEKSC 489

Query: 295 KSGFIQDALGNCI--DINECLSISAPCPIGHTC-----INTEGSYTCQKNVPNCGRGYHL 347
            +G +    G     + N+   IS        C     +  EG  +C+ N PN G  Y  
Sbjct: 490 MAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ-SCESN-PNLG--YPC 545

Query: 348 NE------EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-V 400
           N       EG   + V E   P EP     R   +  + R     G   +  + +  D  
Sbjct: 546 NHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQ 605

Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE-------------------- 440
           +EC   PG LC H C NT+GSY C+C  GF L  DGR+C                     
Sbjct: 606 DECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665

Query: 441 -------------DINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
                          N C  + PC Q C+ V GS  C C  GY +   DGV+CED DEC 
Sbjct: 666 SQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM-ADGVSCEDQDECL 724

Query: 487 LPTGGHICSYR--CINIPGSFQC----SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE 540
           +  G H CS R  C+N  GSF C       + GY L  + R C DI+ECVT +H CS  E
Sbjct: 725 M--GAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAH-RKCVDINECVTDLHTCSRGE 781

Query: 541 TCFNIQGGFRCL-AFECPENY 560
            C N  G F C  A  C   Y
Sbjct: 782 HCVNTLGSFHCYKALTCEPGY 802


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  276 bits (705), Expect = 6e-74
 Identities = 164/472 (34%), Positives = 224/472 (47%), Gaps = 69/472 (14%)

Query: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
            D C  G PC   C +      CSC  G  + +DG +C+D++EC  G H+C  G+ C NT+
Sbjct: 5109 DECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTI 5168

Query: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECE--SGIHNCLPDFICQNTLGSFRCRPKLQC 294
            GS+RC     CG+G+  T D  SC+DI+EC+  S  H       C N +GSF C     C
Sbjct: 5169 GSYRCV--VRCGSGFRRTSDGLSCQDINECQESSPCHQ-----RCFNAIGSFHC----GC 5217

Query: 295  KSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
            + G+ Q     C+D+NEC      C     C NT G Y C   +  C  G    E GT C
Sbjct: 5218 EPGY-QLKGRKCMDVNECR--QNVCRPDQHCKNTRGGYKC---IDLCPNGMTKAENGT-C 5270

Query: 355  VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
            +D+DEC      C     C N+ GS+RC C  GY   G+ R C+D+NEC++ P + C H+
Sbjct: 5271 IDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVP-KPCAHQ 5329

Query: 415  CENTLGSYLCSCSVGFRLSVDGRSCEDI-------------NECSSSPCS---------Q 452
            C NT GS+ C C  G  L  DG+SC  +             N    SP           +
Sbjct: 5330 CSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYR 5389

Query: 453  ECANVYGSYQCY-----------------CRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
            + +++Y SY  Y                 C  G   S+    TC DIDEC        C 
Sbjct: 5390 QYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEG---SEASHDTCVDIDEC---ENTDACQ 5443

Query: 496  YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
            + C N  GS+QC CP  GY+L  NG+ CQDIDEC+    +C  N  CFN++G ++C+   
Sbjct: 5444 HECKNTFGSYQCICP-PGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502

Query: 556  CPENYRRSAATRCERLPCHEN-RECSKLPLRITYYHLSFPTNIQAPAVVFRM 606
            CP NY+R   +      C  N  EC+  P  + Y  +S P  I     + R+
Sbjct: 5503 CPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRL 5554



 Score =  177 bits (448), Expect = 4e-44
 Identities = 108/276 (39%), Positives = 141/276 (51%), Gaps = 35/276 (12%)

Query: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
            QC SGF  D++G  C D +EC   +A  P  H+C N  G+Y C     +C +G  +  +G
Sbjct: 5091 QCPSGFTLDSVGPFCADEDEC---AAGNPCSHSCHNAMGTYYC-----SCPKGLTIAADG 5142

Query: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF----DGISRMCVDVNECQRYP 407
              C D+DECA     C  G  C N+ GS+RC  + G  F    DG+S  C D+NECQ   
Sbjct: 5143 RTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLS--CQDINECQE-- 5198

Query: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-- 463
               C  +C N +GS+ C C  G++L   GR C D+NEC  + C   Q C N  G Y+C  
Sbjct: 5199 SSPCHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCID 5256

Query: 464  YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521
             C  G  ++  +  TC DIDEC    G H C Y   C N  GS++C CP  GYR    GR
Sbjct: 5257 LCPNG--MTKAENGTCIDIDEC--KDGTHQCRYNQICENTRGSYRCVCP-RGYRSQGVGR 5311

Query: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
             C DI+EC      C+    C N  G F+C+   CP
Sbjct: 5312 PCMDINECEQVPKPCA--HQCSNTPGSFKCI---CP 5342



 Score =  176 bits (445), Expect = 8e-44
 Identities = 103/253 (40%), Positives = 129/253 (50%), Gaps = 31/253 (12%)

Query: 341  CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
            C  G+ L+  G  C D DECA    PC   H C N+ G++ C C  G       R C D+
Sbjct: 5092 CPSGFTLDSVGPFCADEDECA-AGNPC--SHSCHNAMGTYYCSCPKGLTIAADGRTCQDI 5148

Query: 401  NECQRYPGR---LCGHKCENTLGSYLC--SCSVGFRLSVDGRSCEDINEC-SSSPCSQEC 454
            +EC    GR     G  C+NT+GSY C   C  GFR + DG SC+DINEC  SSPC Q C
Sbjct: 5149 DECAL--GRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRC 5206

Query: 455  ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC--SYRCINIPGSFQC--SCP 510
             N  GS+ C C  GYQL    G  C D++EC      ++C     C N  G ++C   CP
Sbjct: 5207 FNAIGSFHCGCEPGYQLK---GRKCMDVNECR----QNVCRPDQHCKNTRGGYKCIDLCP 5259

Query: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCER 570
             +G   A NG  C DIDEC  G H C  N+ C N +G +RC+   CP  YR     R   
Sbjct: 5260 -NGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCV---CPRGYRSQGVGR--- 5311

Query: 571  LPCHENRECSKLP 583
             PC +  EC ++P
Sbjct: 5312 -PCMDINECEQVP 5323


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  272 bits (696), Expect = 7e-73
 Identities = 156/433 (36%), Positives = 222/433 (51%), Gaps = 59/433 (13%)

Query: 293 QCKSGFIQDAL-GNCIDINECLSISAPCPIGHTCINTEGSYTC----------------- 334
           QC +GF  D   G C+DI+EC +I   C     C+N  G Y C                 
Sbjct: 26  QCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYS 85

Query: 335 ------------QKNVPN---------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRC 373
                         + PN         C  GY + +E  +CVDVDECA  +  C     C
Sbjct: 86  TPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATDSHQCNPTQIC 144

Query: 374 VNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLS 433
           +N+ G + C C  GY+   +   C+D++EC RY    C   C N  GSY C+C+ GF L+
Sbjct: 145 INTEGGYTCSCTDGYWL--LEGQCLDIDEC-RYG--YCQQLCANVPGSYSCTCNPGFTLN 199

Query: 434 VDGRSCEDINECSS-SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
            DGRSC+D+NEC++ +PC Q C N YGS+ C C  GY+L + DGV C D+DEC+      
Sbjct: 200 EDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE-DGVHCSDMDECSFSE--F 256

Query: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
           +C + C+N PG++ CSCP  GY L  + R+CQDI+EC    H C++ +TC+N+QGGF+C+
Sbjct: 257 LCQHECVNQPGTYFCSCPP-GYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315

Query: 553 -AFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSA 611
               C E Y R +  RC  +   EN  C   P  I Y  +   +    PA +F+M  ++ 
Sbjct: 316 DPIRCEEPYLRISDNRC--MCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTR 373

Query: 612 VPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSF 671
            PG      I  GNE   F  R+  P S  + +T+P+  PR++ L ++M      TV +F
Sbjct: 374 YPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEM--ITVNTVINF 431

Query: 672 ----VAKLFIFVS 680
               V +L I+VS
Sbjct: 432 RGSSVIRLRIYVS 444



 Score =  169 bits (429), Expect = 6e-42
 Identities = 108/335 (32%), Positives = 145/335 (43%), Gaps = 71/335 (21%)

Query: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
           C  +       C  G+ L      C D++EC T   +CR    C+N  G + C       
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 243 --------------------------------QRDSSCGTGYELTEDNSCKDIDECESGI 270
                                            R   C  GY++ E N C D+DEC +  
Sbjct: 76  YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135

Query: 271 HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEG 330
           H C P  IC NT G + C     C  G+     G C+DI+EC      C     C N  G
Sbjct: 136 HQCNPTQICINTEGGYTC----SCTDGYWL-LEGQCLDIDECR--YGYCQ--QLCANVPG 186

Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
           SY+C      C  G+ LNE+G  C DV+ECA    PC +   CVN+ GSF C C  GY  
Sbjct: 187 SYSC-----TCNPGFTLNEDGRSCQDVNECA-TENPCVQ--TCVNTYGSFICRCDPGYEL 238

Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SS 448
           +     C D++EC  +   LC H+C N  G+Y CSC  G+ L  D RSC+DINEC   + 
Sbjct: 239 EEDGVHCSDMDECS-FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNH 297

Query: 449 PCS--QECANVYGSYQCYCRRGYQLSDVDGVTCED 481
            C+  Q C N+ G ++C          +D + CE+
Sbjct: 298 TCNLQQTCYNLQGGFKC----------IDPIRCEE 322



 Score =  103 bits (256), Expect = 7e-22
 Identities = 73/227 (32%), Positives = 109/227 (48%), Gaps = 33/227 (14%)

Query: 158 LQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDV 217
           + E+++ ++V+E   D +   +C       Q C +T     CSC  GY LL     C D+
Sbjct: 119 MDESNQCVDVDECATDSH---QCNP----TQICINTEGGYTCSCTDGYWLLEG--QCLDI 169

Query: 218 NECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPD 276
           +EC  G   C+  + C N  GS+ C    +C  G+ L ED  SC+D++EC +  + C+  
Sbjct: 170 DECRYG--YCQ--QLCANVPGSYSC----TCNPGFTLNEDGRSCQDVNECATE-NPCVQ- 219

Query: 277 FICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
             C NT GSF CR    C  G+  +  G +C D++EC      C   H C+N  G+Y C 
Sbjct: 220 -TCVNTYGSFICR----CDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQPGTYFC- 271

Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382
               +C  GY L ++   C D++EC      C     C N  G F+C
Sbjct: 272 ----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 7/131 (5%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           + C    PC Q C +T    +C C  GY+L  DGV C D++EC      C+    C+N  
Sbjct: 209 NECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ--HECVNQP 266

Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           G++ C    SC  GY L +DN SC+DI+ECE   H C     C N  G F+C   ++C+ 
Sbjct: 267 GTYFC----SCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEE 322

Query: 297 GFIQDALGNCI 307
            +++ +   C+
Sbjct: 323 PYLRISDNRCM 333


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  256 bits (655), Expect = 4e-68
 Identities = 151/377 (40%), Positives = 203/377 (53%), Gaps = 36/377 (9%)

Query: 186  CKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR 244
            C Q +C +T    +C C  G+    +G +C DV+EC+     C  G  C+NTVG+FRC+ 
Sbjct: 927  CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVCGEGH-CVNTVGAFRCE- 983

Query: 245  DSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
               C +GY +T+   C+DIDEC +   +  PD  C N+ GS++C P   C  GF +   G
Sbjct: 984  --YCDSGYRMTQRGRCEDIDECLN--PSTCPDEQCVNSPGSYQCVP---CTEGF-RGWNG 1035

Query: 305  NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
             C+D++ECL  +  C  G  C N EGSY C     +C +GY    +   C D+DEC    
Sbjct: 1036 QCLDVDECLEPNV-CANG-DCSNLEGSYMC-----SCHKGYTRTPDHKHCRDIDEC-QQG 1087

Query: 365  EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYL 423
              C  G +C N+ GSFRC C  GY        C D++ECQ     LC H +C NT GS+ 
Sbjct: 1088 NLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH--RHLCAHGQCRNTEGSFQ 1144

Query: 424  CSCSVGFRLSVDGRSCEDINEC--SSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCE 480
            C C  G+R S  G  CEDINEC    S C + +C N  GSY C C  G+QL   D  TC+
Sbjct: 1145 CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD--DNKTCQ 1202

Query: 481  DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
            DI+EC  P    +C  +  C+N  GSF C C   G+ ++ +GR C+DIDECV     C  
Sbjct: 1203 DINECEHP---GLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNT-VCDS 1257

Query: 539  NETCFNIQGGFRCLAFE 555
            +  C N  G FRCL ++
Sbjct: 1258 HGFCDNTAGSFRCLCYQ 1274



 Score =  182 bits (461), Expect = 1e-45
 Identities = 122/362 (33%), Positives = 169/362 (46%), Gaps = 75/362 (20%)

Query: 253  ELTEDNSCK-DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDIN 310
            ++TE N C  + D C +G         C N    + C     C  G+   +    C+DI+
Sbjct: 871  QVTEINECTVNPDICGAGH--------CINLPVRYTCI----CYEGYRFSEQQRKCVDID 918

Query: 311  ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
            EC  +   C  G  C NTEGS+ C      C  G+  +EEGT C+DVDEC  P + CG+G
Sbjct: 919  ECTQVQHLCSQGR-CENTEGSFLCI-----CPAGFMASEEGTNCIDVDECLRP-DVCGEG 971

Query: 371  HRCVNSPGSFRCE-CKTGYY---------------------------------------F 390
            H CVN+ G+FRCE C +GY                                        F
Sbjct: 972  H-CVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGF 1030

Query: 391  DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP- 449
             G +  C+DV+EC   P       C N  GSY+CSC  G+  + D + C DI+EC     
Sbjct: 1031 RGWNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNL 1089

Query: 450  -CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQC 507
              + +C N  GS++C C +GYQLS      CEDIDEC      H+C++ +C N  GSFQC
Sbjct: 1090 CVNGQCKNTEGSFRCTCGQGYQLSAAKD-QCEDIDEC---QHRHLCAHGQCRNTEGSFQC 1145

Query: 508  SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATR 567
             C   GYR +  G +C+DI+EC+     C   + C N  G + C    CP+ ++      
Sbjct: 1146 VC-DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDC---TCPDGFQLDDNKT 1200

Query: 568  CE 569
            C+
Sbjct: 1201 CQ 1202



 Score =  168 bits (425), Expect = 2e-41
 Identities = 173/630 (27%), Positives = 239/630 (37%), Gaps = 133/630 (21%)

Query: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CAT 80
            ++  V     C +G+R +  Q+ C      +  EC  VQ  C   + E         C  
Sbjct: 891  INLPVRYTCICYEGYRFSEQQRKC-----VDIDECTQVQHLCSQGRCENTEGSFLCICPA 945

Query: 81   GISLANEQ------DRCATPH--GDNASLEATFVKRCCHCCLLGRAAQA----------Q 122
            G   + E       D C  P   G+   +      RC +C    R  Q            
Sbjct: 946  GFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN 1005

Query: 123  GQSCEYSLMVG----YQC---GQVFRAC---------CVKSQETGDLDVGGLQET----- 161
              +C     V     YQC    + FR           C++     + D   L+ +     
Sbjct: 1006 PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC 1065

Query: 162  DKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
             K      + +     D C+ G  C   QC++T     C+C  GYQL +    CED++EC
Sbjct: 1066 HKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDEC 1125

Query: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFIC 279
                H C  G+ C NT GSF+C     C  GY  +   + C+DI+EC      C     C
Sbjct: 1126 -QHRHLCAHGQ-CRNTEGSFQCV----CDQGYRASGLGDHCEDINECLEDKSVCQRGD-C 1178

Query: 280  QNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP 339
             NT GS+ C     C  GF  D    C DINEC       P G  C+NTEGS+ C     
Sbjct: 1179 INTAGSYDCT----CPDGFQLDDNKTCQDINECEHPGLCGPQGE-CLNTEGSFHCV---- 1229

Query: 340  NCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
             C +G+ ++ +G  C D+DEC      C     C N+ GSFRC C  G+      + CVD
Sbjct: 1230 -CQQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 1287

Query: 400  VNECQRYPGRLCGHK-CENTLGSYLCSCS----------------VGFRLSVD-GRSCED 441
            VNEC+   G +CG   CEN  GS+LC C+                    L VD  +  E+
Sbjct: 1288 VNECELLSG-VCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346

Query: 442  INEC-----SSSPC---------SQECANVYGS--------YQC---------------- 463
              EC      +S C          QEC    G+        + C                
Sbjct: 1347 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1406

Query: 464  -YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGR 521
             +   G   S+  G   +D DEC L  G  IC    C+N    ++C C    Y   P   
Sbjct: 1407 GFVPAGESSSEAGGENYKDADECLL-FGQEICKNGFCLNTRPGYECYCKQGTY-YDPVKL 1464

Query: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRC 551
             C D+DEC     +  I+  C N +G + C
Sbjct: 1465 QCFDMDECQD--PSSCIDGQCVNTEGSYNC 1492



 Score =  151 bits (382), Expect = 2e-36
 Identities = 92/272 (33%), Positives = 131/272 (48%), Gaps = 52/272 (19%)

Query: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
            T+  +++EC    + CG GH C+N P  + C C  GY F    R CVD++EC +      
Sbjct: 870  TQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 928

Query: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SSSPCSQ-ECANVYGSYQC-YCRRG 468
              +CENT GS+LC C  GF  S +G +C D++EC     C +  C N  G+++C YC  G
Sbjct: 929  QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSG 988

Query: 469  YQLSDVDGVTCEDIDECALPT-----------GGHIC-----SYR--------------- 497
            Y+++      CEDIDEC  P+           G + C      +R               
Sbjct: 989  YRMTQRG--RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP 1046

Query: 498  -------CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
                   C N+ GS+ CSC   GY   P+ ++C+DIDEC  G  N  +N  C N +G FR
Sbjct: 1047 NVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFR 1103

Query: 551  CLAFECPENYRRSAA-TRCERL-PCHENRECS 580
            C    C + Y+ SAA  +CE +  C     C+
Sbjct: 1104 C---TCGQGYQLSAAKDQCEDIDECQHRHLCA 1132



 Score =  122 bits (306), Expect = 1e-27
 Identities = 169/672 (25%), Positives = 249/672 (37%), Gaps = 145/672 (21%)

Query: 27   VDADVLLEA-CCADG---HRMATHQKDCSLPYAT--ESKECRMVQE-----QCCHSQLEE 75
            +D D  LE   CA+G   +   ++   C   Y    + K CR + E      C + Q + 
Sbjct: 1038 LDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKN 1097

Query: 76   LH------CATGISLANEQDRCAT----------PHGDNASLEATFVKRCCHCCLLGRAA 119
                    C  G  L+  +D+C             HG   + E +F  +C   C  G  A
Sbjct: 1098 TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSF--QCV--CDQGYRA 1153

Query: 120  QAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDV--GGLQETDKIIEVEEEQEDPYLN 177
               G  CE             R  C+ +  + D     G   + +K  +   E E P L 
Sbjct: 1154 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL- 1212

Query: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
              C   GP + +C +T     C C  G+ + +DG +CED++EC+  +  C     C NT 
Sbjct: 1213 --C---GP-QGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSHGFCDNTA 1265

Query: 238  GSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRC-------- 288
            GSFRC     C  G++  +D   C D++ECE     C   F C+N  GSF C        
Sbjct: 1266 GSFRCL----CYQGFQAPQDGQGCVDVNECELLSGVCGEAF-CENVEGSFLCVCADENQE 1320

Query: 289  ---------------------RPKLQCKSGF--IQDA------LGNCIDINECLSISA-- 317
                                 +PK + K  +  + DA      L   +   EC   S   
Sbjct: 1321 YSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG 1380

Query: 318  --------PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG-TRCVDVDECAPPAEPCG 368
                    PCP+  T   TE    C K       G   +E G     D DEC    +   
Sbjct: 1381 WGDNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEIC 1437

Query: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
            K   C+N+   + C CK G Y+D +   C D++ECQ  P      +C NT GSY C C+ 
Sbjct: 1438 KNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTH 1496

Query: 429  GFRLSVDGRSC-------EDINE------------CSSSPCSQECANVYGSY-QCYCRRG 468
               L    + C       E I E                 CS+       +Y +C C  G
Sbjct: 1497 PMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1556

Query: 469  YQLSDVDGVTC-----EDIDE----CALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAP 518
                +  G+ C     +D D+    C +P  G    Y R   +  S Q +  +  Y +  
Sbjct: 1557 ----EAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1612

Query: 519  NGRNCQD---IDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHE 575
               N  +    +EC  GI N   N  C  +Q G+ C   +C + Y    A    ++ C +
Sbjct: 1613 RFLNSFEELQAEEC--GILNGCENGRCVRVQEGYTC---DCFDGYHLDTA----KMTCVD 1663

Query: 576  NRECSKLPLRIT 587
              EC +L  R++
Sbjct: 1664 VNECDELNNRMS 1675



 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 114/462 (24%), Positives = 165/462 (35%), Gaps = 103/462 (22%)

Query: 178  DRCRGGGPCKQQ--CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES-CI 234
            D C     C     C +T     C C+ G+Q   DG  C DVNEC   S  C  GE+ C 
Sbjct: 1247 DECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC--GEAFCE 1304

Query: 235  NTVGSFRC-----QRDSSCGTGYELTEDNSCKDID------ECESGIHNCLPDFICQNTL 283
            N  GSF C      ++ S  TG   +  ++  D+D      E +   +N     +C N L
Sbjct: 1305 NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1364

Query: 284  GSFRCRPKLQCKSG---------FIQDALG---------------------------NCI 307
                 + +  C SG         F    LG                           N  
Sbjct: 1365 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1424

Query: 308  DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
            D +ECL           C+NT   Y C      C +G + +    +C D+DEC  P+  C
Sbjct: 1425 DADECLLFGQEICKNGFCLNTRPGYECY-----CKQGTYYDPVKLQCFDMDECQDPSS-C 1478

Query: 368  GKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------DVNECQRYPGRLCGHKCENTLG 420
              G +CVN+ GS+ C C      D   + C+        + E   Y   LC    E+   
Sbjct: 1479 IDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQD-LCW---EHLSD 1533

Query: 421  SYLCSCSVGFRLSVDGRSCEDINECSSSPCS-----------QEC-ANVYGSYQCYCRRG 468
             Y+CS  +  + +     C    E     C+           Q C   V G  Q Y R  
Sbjct: 1534 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1593

Query: 469  --------------YQLSDVDGVTCEDI--DECALPTGGHICSYRCINIPGSFQCSCPSS 512
                          Y + D    + E++  +EC +  G    + RC+ +   + C C   
Sbjct: 1594 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCE--NGRCVRVQEGYTCDC-FD 1650

Query: 513  GYRLAPNGRNCQDIDECVTGIHNCSI--NETCFNIQGGFRCL 552
            GY L      C D++EC    +  S+  N  C N  G ++CL
Sbjct: 1651 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1692



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 80/293 (27%), Positives = 107/293 (36%), Gaps = 63/293 (21%)

Query: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
            C +T     C C  G       + C D++EC   S SC  G+ C+NT GS+ C       
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1499

Query: 243  --QRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTL-GSFRCRPKLQCKSG 297
                +  C    E  E     D+  D C   + +   +++C   L G      +  C  G
Sbjct: 1500 LDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD---EYVCSRPLVGKQTTYTECCCLYG 1556

Query: 298  FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
               +A G      +C    A CP+          Y    N+P  GR      +    VD 
Sbjct: 1557 ---EAWGM-----QC----ALCPL-----KDSDDYAQLCNIPVTGRRQPYGRDAL--VDF 1597

Query: 358  DECAPP-------------------AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGI 393
             E   P                   AE CG     +  RCV     + C+C  GY+ D  
Sbjct: 1598 SEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTA 1657

Query: 394  SRMCVDVNECQRYPGR--LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
               CVDVNEC     R  LC + KC NT GSY C C  G+  S     C  +N
Sbjct: 1658 KMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 133/557 (23%), Positives = 182/557 (32%), Gaps = 173/557 (31%)

Query: 49   DCSLP---YATESKECRMVQE----QCCHSQLEELH--------CATGISLANEQDRC-- 91
            DC+ P      ++K C+ + E      C  Q E L+        C  G S++ +   C  
Sbjct: 1186 DCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCED 1245

Query: 92   ---------ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSC----EYSLMVGYQCGQ 138
                        HG   +   +F  RC   C  G  A   GQ C    E  L+ G  CG+
Sbjct: 1246 IDECVNNTVCDSHGFCDNTAGSF--RCL--CYQGFQAPQDGQGCVDVNECELLSGV-CGE 1300

Query: 139  VFR---------ACCVKSQE----TG--------DLDVGGLQETDKIIEVEEEQEDPYLN 177
             F           C  ++QE    TG        DLDV   Q  ++  E      D  L 
Sbjct: 1301 AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1360

Query: 178  DRCRGGGPCKQQCRDT-----GD-------------EVVCSCFVGYQLLSDGVSC----- 214
            D        KQ+C  T     GD             E    C  G   +  G S      
Sbjct: 1361 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1420

Query: 215  ---EDVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
               +D +EC+  G   C+ G  C+NT   + C      GT Y+  +   C D+DEC+   
Sbjct: 1421 ENYKDADECLLFGQEICKNG-FCLNTRPGYECYCKQ--GTYYDPVK-LQCFDMDECQDP- 1475

Query: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA---------------------------- 302
             +C+ D  C NT GS+ C     C    + DA                            
Sbjct: 1476 SSCI-DGQCVNTEGSYNCF----CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEH 1530

Query: 303  -----------LGNCIDINECLSI--------SAPCPIGHTCINTEGSYTCQKNVPNCGR 343
                       +G      EC  +         A CP+          Y    N+P  GR
Sbjct: 1531 LSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL-----KDSDDYAQLCNIPVTGR 1585

Query: 344  GYHLNEEGTRCVDVDE-CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNE 402
                  +    VD  E   P A+P     R +NS    + E             C  +N 
Sbjct: 1586 RQPYGRDAL--VDFSEQYTPEADPYFIQDRFLNSFEELQAE------------ECGILNG 1631

Query: 403  CQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-----SPCSQ-ECAN 456
            C+         +C      Y C C  G+ L     +C D+NEC       S C   +C N
Sbjct: 1632 CEN-------GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684

Query: 457  VYGSYQCYCRRGYQLSD 473
              GSY+C C  GY  SD
Sbjct: 1685 TDGSYKCLCLPGYVPSD 1701



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 37/109 (33%), Positives = 45/109 (41%), Gaps = 13/109 (11%)

Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
           SY     +  C  GY      T C D++EC      C  G  C+N+ GS+RC CK G+  
Sbjct: 602 SYHGYNQMMECLPGYK-RVNNTFCQDINECQLQGV-CPNGE-CLNTMGSYRCTCKIGFGP 658

Query: 391 DGISRMCV--------DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
           D     CV        +   C R    GR C H     L   LC CSVG
Sbjct: 659 DPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 707



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 23/94 (24%)

Query: 231 ESCINTVGSF-------RCQRDSS---------CGTGYELTEDNSCKDIDECESGIHNCL 274
           E C  TVG+        +C +  S         C  GY+   +  C+DI+EC+  +    
Sbjct: 579 EDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVC 636

Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCI 307
           P+  C NT+GS+RC     CK GF  D    +C+
Sbjct: 637 PNGECLNTMGSYRC----TCKIGFGPDPTFSSCV 666



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 8/71 (11%)

Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANVY 458
           N+CQ+ P +   H     +      C  G++  V+   C+DINEC     C   EC N  
Sbjct: 592 NKCQKCPKKPSYHGYNQMM-----ECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTM 645

Query: 459 GSYQCYCRRGY 469
           GSY+C C+ G+
Sbjct: 646 GSYRCTCKIGF 656



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 2/57 (3%)

Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
           EC  GY     +  C D+NECQ   G     +C NT+GSY C+C +GF       SC
Sbjct: 611 ECLPGYKRVN-NTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)

Query: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNC 523
           C  GY+   V+   C+DI+EC L   G   +  C+N  GS++C+C   G+   P   +C
Sbjct: 612 CLPGYKR--VNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTC-KIGFGPDPTFSSC 665


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  256 bits (655), Expect = 4e-68
 Identities = 151/377 (40%), Positives = 203/377 (53%), Gaps = 36/377 (9%)

Query: 186 CKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR 244
           C Q +C +T    +C C  G+    +G +C DV+EC+     C  G  C+NTVG+FRC+ 
Sbjct: 601 CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR-PDVCGEGH-CVNTVGAFRCE- 657

Query: 245 DSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
              C +GY +T+   C+DIDEC +   +  PD  C N+ GS++C P   C  GF +   G
Sbjct: 658 --YCDSGYRMTQRGRCEDIDECLN--PSTCPDEQCVNSPGSYQCVP---CTEGF-RGWNG 709

Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
            C+D++ECL  +  C  G  C N EGSY C     +C +GY    +   C D+DEC    
Sbjct: 710 QCLDVDECLEPNV-CANG-DCSNLEGSYMC-----SCHKGYTRTPDHKHCRDIDEC-QQG 761

Query: 365 EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYL 423
             C  G +C N+ GSFRC C  GY        C D++ECQ     LC H +C NT GS+ 
Sbjct: 762 NLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH--RHLCAHGQCRNTEGSFQ 818

Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCE 480
           C C  G+R S  G  CEDINEC    S C + +C N  GSY C C  G+QL   D  TC+
Sbjct: 819 CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD--DNKTCQ 876

Query: 481 DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
           DI+EC  P    +C  +  C+N  GSF C C   G+ ++ +GR C+DIDECV     C  
Sbjct: 877 DINECEHP---GLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNT-VCDS 931

Query: 539 NETCFNIQGGFRCLAFE 555
           +  C N  G FRCL ++
Sbjct: 932 HGFCDNTAGSFRCLCYQ 948



 Score =  182 bits (461), Expect = 1e-45
 Identities = 122/362 (33%), Positives = 169/362 (46%), Gaps = 75/362 (20%)

Query: 253 ELTEDNSCK-DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDIN 310
           ++TE N C  + D C +G         C N    + C     C  G+   +    C+DI+
Sbjct: 545 QVTEINECTVNPDICGAGH--------CINLPVRYTCI----CYEGYRFSEQQRKCVDID 592

Query: 311 ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
           EC  +   C  G  C NTEGS+ C      C  G+  +EEGT C+DVDEC  P + CG+G
Sbjct: 593 ECTQVQHLCSQGR-CENTEGSFLCI-----CPAGFMASEEGTNCIDVDECLRP-DVCGEG 645

Query: 371 HRCVNSPGSFRCE-CKTGYY---------------------------------------F 390
           H CVN+ G+FRCE C +GY                                        F
Sbjct: 646 H-CVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGF 704

Query: 391 DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP- 449
            G +  C+DV+EC   P       C N  GSY+CSC  G+  + D + C DI+EC     
Sbjct: 705 RGWNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNL 763

Query: 450 -CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQC 507
             + +C N  GS++C C +GYQLS      CEDIDEC      H+C++ +C N  GSFQC
Sbjct: 764 CVNGQCKNTEGSFRCTCGQGYQLSAAKD-QCEDIDEC---QHRHLCAHGQCRNTEGSFQC 819

Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATR 567
            C   GYR +  G +C+DI+EC+     C   + C N  G + C    CP+ ++      
Sbjct: 820 VC-DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDC---TCPDGFQLDDNKT 874

Query: 568 CE 569
           C+
Sbjct: 875 CQ 876



 Score =  168 bits (425), Expect = 2e-41
 Identities = 173/630 (27%), Positives = 239/630 (37%), Gaps = 133/630 (21%)

Query: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CAT 80
            ++  V     C +G+R +  Q+ C      +  EC  VQ  C   + E         C  
Sbjct: 565  INLPVRYTCICYEGYRFSEQQRKC-----VDIDECTQVQHLCSQGRCENTEGSFLCICPA 619

Query: 81   GISLANEQ------DRCATPH--GDNASLEATFVKRCCHCCLLGRAAQA----------Q 122
            G   + E       D C  P   G+   +      RC +C    R  Q            
Sbjct: 620  GFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN 679

Query: 123  GQSCEYSLMVG----YQC---GQVFRAC---------CVKSQETGDLDVGGLQET----- 161
              +C     V     YQC    + FR           C++     + D   L+ +     
Sbjct: 680  PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC 739

Query: 162  DKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
             K      + +     D C+ G  C   QC++T     C+C  GYQL +    CED++EC
Sbjct: 740  HKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDEC 799

Query: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFIC 279
                H C  G+ C NT GSF+C     C  GY  +   + C+DI+EC      C     C
Sbjct: 800  -QHRHLCAHGQ-CRNTEGSFQCV----CDQGYRASGLGDHCEDINECLEDKSVCQRGD-C 852

Query: 280  QNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP 339
             NT GS+ C     C  GF  D    C DINEC       P G  C+NTEGS+ C     
Sbjct: 853  INTAGSYDCT----CPDGFQLDDNKTCQDINECEHPGLCGPQGE-CLNTEGSFHCV---- 903

Query: 340  NCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
             C +G+ ++ +G  C D+DEC      C     C N+ GSFRC C  G+      + CVD
Sbjct: 904  -CQQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 961

Query: 400  VNECQRYPGRLCGHK-CENTLGSYLCSCS----------------VGFRLSVD-GRSCED 441
            VNEC+   G +CG   CEN  GS+LC C+                    L VD  +  E+
Sbjct: 962  VNECELLSG-VCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020

Query: 442  INEC-----SSSPC---------SQECANVYGS--------YQC---------------- 463
              EC      +S C          QEC    G+        + C                
Sbjct: 1021 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1080

Query: 464  -YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGR 521
             +   G   S+  G   +D DEC L  G  IC    C+N    ++C C    Y   P   
Sbjct: 1081 GFVPAGESSSEAGGENYKDADECLL-FGQEICKNGFCLNTRPGYECYCKQGTY-YDPVKL 1138

Query: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRC 551
             C D+DEC     +  I+  C N +G + C
Sbjct: 1139 QCFDMDECQD--PSSCIDGQCVNTEGSYNC 1166



 Score =  151 bits (382), Expect = 2e-36
 Identities = 92/272 (33%), Positives = 131/272 (48%), Gaps = 52/272 (19%)

Query: 352 TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
           T+  +++EC    + CG GH C+N P  + C C  GY F    R CVD++EC +      
Sbjct: 544 TQVTEINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 602

Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SSSPCSQ-ECANVYGSYQC-YCRRG 468
             +CENT GS+LC C  GF  S +G +C D++EC     C +  C N  G+++C YC  G
Sbjct: 603 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSG 662

Query: 469 YQLSDVDGVTCEDIDECALPT-----------GGHIC-----SYR--------------- 497
           Y+++      CEDIDEC  P+           G + C      +R               
Sbjct: 663 YRMTQRG--RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP 720

Query: 498 -------CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
                  C N+ GS+ CSC   GY   P+ ++C+DIDEC  G  N  +N  C N +G FR
Sbjct: 721 NVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFR 777

Query: 551 CLAFECPENYRRSAA-TRCERL-PCHENRECS 580
           C    C + Y+ SAA  +CE +  C     C+
Sbjct: 778 C---TCGQGYQLSAAKDQCEDIDECQHRHLCA 806



 Score =  122 bits (306), Expect = 1e-27
 Identities = 169/672 (25%), Positives = 249/672 (37%), Gaps = 145/672 (21%)

Query: 27   VDADVLLEA-CCADG---HRMATHQKDCSLPYAT--ESKECRMVQE-----QCCHSQLEE 75
            +D D  LE   CA+G   +   ++   C   Y    + K CR + E      C + Q + 
Sbjct: 712  LDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKN 771

Query: 76   LH------CATGISLANEQDRCAT----------PHGDNASLEATFVKRCCHCCLLGRAA 119
                    C  G  L+  +D+C             HG   + E +F  +C   C  G  A
Sbjct: 772  TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSF--QCV--CDQGYRA 827

Query: 120  QAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDV--GGLQETDKIIEVEEEQEDPYLN 177
               G  CE             R  C+ +  + D     G   + +K  +   E E P L 
Sbjct: 828  SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL- 886

Query: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
              C   GP + +C +T     C C  G+ + +DG +CED++EC+  +  C     C NT 
Sbjct: 887  --C---GP-QGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSHGFCDNTA 939

Query: 238  GSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRC-------- 288
            GSFRC     C  G++  +D   C D++ECE     C   F C+N  GSF C        
Sbjct: 940  GSFRCL----CYQGFQAPQDGQGCVDVNECELLSGVCGEAF-CENVEGSFLCVCADENQE 994

Query: 289  ---------------------RPKLQCKSGF--IQDA------LGNCIDINECLSISA-- 317
                                 +PK + K  +  + DA      L   +   EC   S   
Sbjct: 995  YSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG 1054

Query: 318  --------PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG-TRCVDVDECAPPAEPCG 368
                    PCP+  T   TE    C K       G   +E G     D DEC    +   
Sbjct: 1055 WGDNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEIC 1111

Query: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
            K   C+N+   + C CK G Y+D +   C D++ECQ  P      +C NT GSY C C+ 
Sbjct: 1112 KNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTH 1170

Query: 429  GFRLSVDGRSC-------EDINE------------CSSSPCSQECANVYGSY-QCYCRRG 468
               L    + C       E I E                 CS+       +Y +C C  G
Sbjct: 1171 PMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYG 1230

Query: 469  YQLSDVDGVTC-----EDIDE----CALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAP 518
                +  G+ C     +D D+    C +P  G    Y R   +  S Q +  +  Y +  
Sbjct: 1231 ----EAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1286

Query: 519  NGRNCQD---IDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHE 575
               N  +    +EC  GI N   N  C  +Q G+ C   +C + Y    A    ++ C +
Sbjct: 1287 RFLNSFEELQAEEC--GILNGCENGRCVRVQEGYTC---DCFDGYHLDTA----KMTCVD 1337

Query: 576  NRECSKLPLRIT 587
              EC +L  R++
Sbjct: 1338 VNECDELNNRMS 1349



 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 114/462 (24%), Positives = 165/462 (35%), Gaps = 103/462 (22%)

Query: 178  DRCRGGGPCKQQ--CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES-CI 234
            D C     C     C +T     C C+ G+Q   DG  C DVNEC   S  C  GE+ C 
Sbjct: 921  DECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC--GEAFCE 978

Query: 235  NTVGSFRC-----QRDSSCGTGYELTEDNSCKDID------ECESGIHNCLPDFICQNTL 283
            N  GSF C      ++ S  TG   +  ++  D+D      E +   +N     +C N L
Sbjct: 979  NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1038

Query: 284  GSFRCRPKLQCKSG---------FIQDALG---------------------------NCI 307
                 + +  C SG         F    LG                           N  
Sbjct: 1039 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1098

Query: 308  DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
            D +ECL           C+NT   Y C      C +G + +    +C D+DEC  P+  C
Sbjct: 1099 DADECLLFGQEICKNGFCLNTRPGYECY-----CKQGTYYDPVKLQCFDMDECQDPSS-C 1152

Query: 368  GKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------DVNECQRYPGRLCGHKCENTLG 420
              G +CVN+ GS+ C C      D   + C+        + E   Y   LC    E+   
Sbjct: 1153 IDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQD-LCW---EHLSD 1207

Query: 421  SYLCSCSVGFRLSVDGRSCEDINECSSSPCS-----------QEC-ANVYGSYQCYCRRG 468
             Y+CS  +  + +     C    E     C+           Q C   V G  Q Y R  
Sbjct: 1208 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1267

Query: 469  --------------YQLSDVDGVTCEDI--DECALPTGGHICSYRCINIPGSFQCSCPSS 512
                          Y + D    + E++  +EC +  G    + RC+ +   + C C   
Sbjct: 1268 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCE--NGRCVRVQEGYTCDC-FD 1324

Query: 513  GYRLAPNGRNCQDIDECVTGIHNCSI--NETCFNIQGGFRCL 552
            GY L      C D++EC    +  S+  N  C N  G ++CL
Sbjct: 1325 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 80/293 (27%), Positives = 107/293 (36%), Gaps = 63/293 (21%)

Query: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242
            C +T     C C  G       + C D++EC   S SC  G+ C+NT GS+ C       
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS-SCIDGQ-CVNTEGSYNCFCTHPMV 1173

Query: 243  --QRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTL-GSFRCRPKLQCKSG 297
                +  C    E  E     D+  D C   + +   +++C   L G      +  C  G
Sbjct: 1174 LDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD---EYVCSRPLVGKQTTYTECCCLYG 1230

Query: 298  FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
               +A G      +C    A CP+          Y    N+P  GR      +    VD 
Sbjct: 1231 ---EAWGM-----QC----ALCPL-----KDSDDYAQLCNIPVTGRRQPYGRDAL--VDF 1271

Query: 358  DECAPP-------------------AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGI 393
             E   P                   AE CG     +  RCV     + C+C  GY+ D  
Sbjct: 1272 SEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTA 1331

Query: 394  SRMCVDVNECQRYPGR--LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
               CVDVNEC     R  LC + KC NT GSY C C  G+  S     C  +N
Sbjct: 1332 KMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 133/557 (23%), Positives = 182/557 (32%), Gaps = 173/557 (31%)

Query: 49   DCSLP---YATESKECRMVQE----QCCHSQLEELH--------CATGISLANEQDRC-- 91
            DC+ P      ++K C+ + E      C  Q E L+        C  G S++ +   C  
Sbjct: 860  DCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCED 919

Query: 92   ---------ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSC----EYSLMVGYQCGQ 138
                        HG   +   +F  RC   C  G  A   GQ C    E  L+ G  CG+
Sbjct: 920  IDECVNNTVCDSHGFCDNTAGSF--RCL--CYQGFQAPQDGQGCVDVNECELLSGV-CGE 974

Query: 139  VFR---------ACCVKSQE----TG--------DLDVGGLQETDKIIEVEEEQEDPYLN 177
             F           C  ++QE    TG        DLDV   Q  ++  E      D  L 
Sbjct: 975  AFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLC 1034

Query: 178  DRCRGGGPCKQQCRDT-----GD-------------EVVCSCFVGYQLLSDGVSC----- 214
            D        KQ+C  T     GD             E    C  G   +  G S      
Sbjct: 1035 DNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGG 1094

Query: 215  ---EDVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
               +D +EC+  G   C+ G  C+NT   + C      GT Y+  +   C D+DEC+   
Sbjct: 1095 ENYKDADECLLFGQEICKNG-FCLNTRPGYECYCKQ--GTYYDPVK-LQCFDMDECQDP- 1149

Query: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA---------------------------- 302
             +C+ D  C NT GS+ C     C    + DA                            
Sbjct: 1150 SSCI-DGQCVNTEGSYNCF----CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEH 1204

Query: 303  -----------LGNCIDINECLSI--------SAPCPIGHTCINTEGSYTCQKNVPNCGR 343
                       +G      EC  +         A CP+          Y    N+P  GR
Sbjct: 1205 LSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPL-----KDSDDYAQLCNIPVTGR 1259

Query: 344  GYHLNEEGTRCVDVDE-CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNE 402
                  +    VD  E   P A+P     R +NS    + E             C  +N 
Sbjct: 1260 RQPYGRDAL--VDFSEQYTPEADPYFIQDRFLNSFEELQAE------------ECGILNG 1305

Query: 403  CQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-----SPCSQ-ECAN 456
            C+         +C      Y C C  G+ L     +C D+NEC       S C   +C N
Sbjct: 1306 CEN-------GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358

Query: 457  VYGSYQCYCRRGYQLSD 473
              GSY+C C  GY  SD
Sbjct: 1359 TDGSYKCLCLPGYVPSD 1375



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 37/109 (33%), Positives = 45/109 (41%), Gaps = 13/109 (11%)

Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
           SY     +  C  GY      T C D++EC      C  G  C+N+ GS+RC CK G+  
Sbjct: 276 SYHGYNQMMECLPGYK-RVNNTFCQDINECQLQGV-CPNGE-CLNTMGSYRCTCKIGFGP 332

Query: 391 DGISRMCV--------DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
           D     CV        +   C R    GR C H     L   LC CSVG
Sbjct: 333 DPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG 381



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 23/94 (24%)

Query: 231 ESCINTVGSF-------RCQRDSS---------CGTGYELTEDNSCKDIDECESGIHNCL 274
           E C  TVG+        +C +  S         C  GY+   +  C+DI+EC+  +    
Sbjct: 253 EDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVC 310

Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCI 307
           P+  C NT+GS+RC     CK GF  D    +C+
Sbjct: 311 PNGECLNTMGSYRC----TCKIGFGPDPTFSSCV 340



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 8/71 (11%)

Query: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANVY 458
           N+CQ+ P +   H     +      C  G++  V+   C+DINEC     C   EC N  
Sbjct: 266 NKCQKCPKKPSYHGYNQMM-----ECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTM 319

Query: 459 GSYQCYCRRGY 469
           GSY+C C+ G+
Sbjct: 320 GSYRCTCKIGF 330



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 2/57 (3%)

Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
           EC  GY     +  C D+NECQ   G     +C NT+GSY C+C +GF       SC
Sbjct: 285 ECLPGYKRVN-NTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)

Query: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNC 523
           C  GY+   V+   C+DI+EC L   G   +  C+N  GS++C+C   G+   P   +C
Sbjct: 286 CLPGYKR--VNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTC-KIGFGPDPTFSSC 339


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  250 bits (639), Expect = 3e-66
 Identities = 176/580 (30%), Positives = 254/580 (43%), Gaps = 120/580 (20%)

Query: 34   EACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE------ELHCATGISLANE 87
            E  C  G   AT +     P+  +  EC+M+   C H +        +  C +G +L +E
Sbjct: 1005 EELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSE 1064

Query: 88   QDRCATPHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACC 144
            +  C            T +  C      C  G+     G   E     GY+ G +    C
Sbjct: 1065 ERNC------------TDIDECRISPDLCGRGQCVNTPG-DFECKCDEGYESGFMMMKNC 1111

Query: 145  VKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVG 204
                                ++++E Q DP L   CRGG      C +T     C C  G
Sbjct: 1112 --------------------MDIDECQRDPLL---CRGG-----VCHNTEGSYRCECPPG 1143

Query: 205  YQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC---------------------- 242
            +QL  +  +C D+NEC   +H C  G  C+N +G ++C                      
Sbjct: 1144 HQLSPNISACIDINECELSAHLCPNGR-CVNLIGKYQCACNPGYHSTPDRLFCVDIDECS 1202

Query: 243  ---------------QRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSF 286
                             + SC  G+ L  D  SC DIDECE   + C     C N  G +
Sbjct: 1203 IMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNIC-DGGQCTNIPGEY 1261

Query: 287  RCRPKLQCKSGFI-QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY 345
            RC     C  GF+  + +  C+D+NEC  ++    +  TC NT+GS+ C     +C  GY
Sbjct: 1262 RC----LCYDGFMASEDMKTCVDVNEC-DLNPNICLSGTCENTKGSFIC-----HCDMGY 1311

Query: 346  HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
               +  T C D++EC   A  CGK   C N+ GSF+C C  G+  DGI   C D++EC  
Sbjct: 1312 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIK--CTDLDECSN 1369

Query: 406  YPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQ-ECANVYGSY 461
                   H  C+NT+GSY C C  G+  + DG +C D++ECS   + C   +C N  G Y
Sbjct: 1370 GTHMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGY 1427

Query: 462  QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNG 520
            +C C  G+ +   DG  CEDIDEC+LP   +IC +  C N+PG F+C C   GY L  +G
Sbjct: 1428 RCECDMGF-VPSADGKACEDIDECSLP---NICVFGTCHNLPGLFRCEC-EIGYELDRSG 1482

Query: 521  RNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
             NC D++EC+       I+  C N  G + C   +CP ++
Sbjct: 1483 GNCTDVNECLD--PTTCISGNCVNTPGSYIC---DCPPDF 1517



 Score =  228 bits (581), Expect = 1e-59
 Identities = 144/402 (35%), Positives = 200/402 (49%), Gaps = 45/402 (11%)

Query: 189  QCRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSS 247
            QC +T  +  C C  GY+       +C D++EC      CR G  C NT GS+RC+    
Sbjct: 1085 QCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCR-GGVCHNTEGSYRCE---- 1139

Query: 248  CGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALG 304
            C  G++L+ + ++C DI+ECE   H C P+  C N +G ++C     C  G+    D L 
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLC-PNGRCVNLIGKYQCA----CNPGYHSTPDRLF 1194

Query: 305  NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPA 364
             C+DI+EC  ++  C     C N+EGSY C     +C  G+ L  +   C D+DEC    
Sbjct: 1195 -CVDIDECSIMNGGCET--FCTNSEGSYEC-----SCQPGFALMPDQRSCTDIDECEDNP 1246

Query: 365  EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLC 424
              C  G +C N PG +RC C  G+      + CVDVNEC   P       CENT GS++C
Sbjct: 1247 NICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFIC 1305

Query: 425  SCSVGFRLSVDGRSCEDINEC--SSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCE 480
             C +G+        C DINEC   +  C +   C N  GS++C C  G+     DG+ C 
Sbjct: 1306 HCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW---IGDGIKCT 1362

Query: 481  DIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSI 538
            D+DEC+   G H+CS    C N  GS++C C   GY    +G  C D+DEC   ++ C  
Sbjct: 1363 DLDECS--NGTHMCSQHADCKNTMGSYRCLC-KEGY--TGDGFTCTDLDECSENLNLCG- 1416

Query: 539  NETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
            N  C N  GG+RC   EC   +  SA  +     C +  ECS
Sbjct: 1417 NGQCLNAPGGYRC---ECDMGFVPSADGKA----CEDIDECS 1451



 Score =  218 bits (556), Expect = 1e-56
 Identities = 184/631 (29%), Positives = 253/631 (40%), Gaps = 120/631 (19%)

Query: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68
            PLL  GG+     G          C  GH+++ +   C      +  EC +    C    
Sbjct: 1121 PLLCRGGVCHNTEGS-----YRCECPPGHQLSPNISAC-----IDINECELSAHLCPNGR 1170

Query: 69   CHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCC-------HC-CLLGRAAQ 120
            C + + +  CA      +  DR      D  S+     +  C        C C  G A  
Sbjct: 1171 CVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALM 1230

Query: 121  AQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVEE 169
               +SC          ++  G QC  +   +R  C       +       +    ++V E
Sbjct: 1231 PDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASE-------DMKTCVDVNE 1283

Query: 170  EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
               +P +   C  G      C +T    +C C +GY        C D+NEC  G+H+C  
Sbjct: 1284 CDLNPNI---CLSG-----TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGK 1335

Query: 230  GESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
               C NT GSF+C    SC  G+ + +   C D+DEC +G H C     C+NT+GS+RC 
Sbjct: 1336 HAVCTNTAGSFKC----SCSPGW-IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCL 1390

Query: 290  PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
                CK G+  D    C D++EC      C  G  C+N  G Y C+     C  G+  + 
Sbjct: 1391 ----CKEGYTGDGF-TCTDLDECSENLNLCGNGQ-CLNAPGGYRCE-----CDMGFVPSA 1439

Query: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
            +G  C D+DEC+ P   C  G  C N PG FRCEC+ GY  D     C DVNEC   P  
Sbjct: 1440 DGKACEDIDECSLP-NICVFG-TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLD-PTT 1496

Query: 410  LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN------------ECSSSPCSQECANV 457
                 C NT GSY+C C   F L+     C D              +   + CS E    
Sbjct: 1497 CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVG 1556

Query: 458  YGSYQCYCRRG-----------------YQLSDVDG---------VTCEDIDECALPTGG 491
                 C C  G                 Y++    G         V  EDIDEC    G 
Sbjct: 1557 VSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPG- 1615

Query: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGF 549
             +C   +CIN  GSFQC CP +GY L  + R C D++EC T GI  C    TC+N  G +
Sbjct: 1616 -LCQGGKCINTFGSFQCRCP-TGYYLNEDTRVCDDVNECETPGI--CGPG-TCYNTVGNY 1670

Query: 550  RCLAFECPENYRR-SAATRC---ERLPCHEN 576
             C+   CP +Y + +    C    R  C+ N
Sbjct: 1671 TCI---CPPDYMQVNGGNNCMDMRRSLCYRN 1698



 Score =  214 bits (544), Expect = 3e-55
 Identities = 167/535 (31%), Positives = 236/535 (44%), Gaps = 74/535 (13%)

Query: 59   KECRMVQEQCCHSQLEELHCATGISLANEQD-RCATPHGD------NASLEATFVKRCCH 111
            K C  + E     Q + L C  G+    E   RC  P G       +A ++    +   H
Sbjct: 1109 KNCMDIDE----CQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAH 1164

Query: 112  CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
             C  GR     G+         YQC     AC          + G     D++  V+ + 
Sbjct: 1165 LCPNGRCVNLIGK---------YQC-----AC----------NPGYHSTPDRLFCVDID- 1199

Query: 172  EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
            E   +N      G C+  C ++     CSC  G+ L+ D  SC D++EC    + C  G 
Sbjct: 1200 ECSIMN------GGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICD-GG 1252

Query: 232  SCINTVGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
             C N  G +RC     C  G+  +ED  +C D++EC+   + CL    C+NT GSF C  
Sbjct: 1253 QCTNIPGEYRC----LCYDGFMASEDMKTCVDVNECDLNPNICLSG-TCENTKGSFIC-- 1305

Query: 291  KLQCKSGFI-QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
               C  G+  +     C DINEC   +  C     C NT GS+ C     +C  G+    
Sbjct: 1306 --HCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKC-----SCSPGW--IG 1356

Query: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
            +G +C D+DEC+     C +   C N+ GS+RC CK GY  DG +  C D++EC      
Sbjct: 1357 DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFT--CTDLDECSENL-N 1413

Query: 410  LCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCR 466
            LCG+ +C N  G Y C C +GF  S DG++CEDI+ECS  +      C N+ G ++C C 
Sbjct: 1414 LCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECE 1473

Query: 467  RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
             GY+L D  G  C D++EC  PT     S  C+N PGS+ C CP   + L P    C D 
Sbjct: 1474 IGYEL-DRSGGNCTDVNECLDPT--TCISGNCVNTPGSYICDCPPD-FELNPTRVGCVDT 1529

Query: 527  --DECVTGIHNCSIN-ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRE 578
                C   I     N +T  + + G       C  +  ++  T CE  P     E
Sbjct: 1530 RSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSE 1584



 Score =  210 bits (534), Expect = 4e-54
 Identities = 146/414 (35%), Positives = 190/414 (45%), Gaps = 56/414 (13%)

Query: 184  GPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNE--CITG--SHSCRLGESCINTVG 238
            G C+  +C +T     C C  G+    +   C D  E  C T    + C++G S  N V 
Sbjct: 2300 GICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVT 2359

Query: 239  SFRCQRDSSCGTGYE---------LTEDNSCK----------DIDECESGIHNCLPDFIC 279
               C  D   G G           +     C           DIDEC+  IH+   +  C
Sbjct: 2360 KSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKV-IHDVCRNGEC 2418

Query: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
             N  GS+ C     CK+G+  D  G +C+D+NEC    AP P    C NTEGSY C    
Sbjct: 2419 VNDRGSYHCI----CKTGYTPDITGTSCVDLNECNQ--APKPCNFICKNTEGSYQC---- 2468

Query: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
             +C +GY L E+G  C D+DECA     C     CVN+ G F C+C  G+     S  C+
Sbjct: 2469 -SCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTCKCPPGFTQHHTS--CI 2523

Query: 399  DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECA 455
            D NEC      LCG K  C+NT GS+ C C  GF L   G SCED++EC  +  C   C 
Sbjct: 2524 DNNECTS-DINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQ 2582

Query: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS-YRCINIPGSFQCSCPSSGY 514
            N+ G Y+C C +GY L       C D +EC      HIC    C N  GS++C CP+ G+
Sbjct: 2583 NIIGGYRCSCPQGY-LQHYQWNQCVDENECL---SAHICGGASCHNTLGSYKCMCPA-GF 2637

Query: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRC 568
            +       CQDI+EC +    CS    C N +GG+ C    CP  Y R     C
Sbjct: 2638 QYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLC---GCPPGYFRIGQGHC 2686



 Score =  209 bits (533), Expect = 5e-54
 Identities = 140/436 (32%), Positives = 193/436 (44%), Gaps = 60/436 (13%)

Query: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C  G PC    C++      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 2168 DECSVGNPCGNGTCKNVIGGFECTCEEGFEP-GPMMTCEDINECAQNPLLCAF--RCVNT 2224

Query: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFI-CQNTLGSFRCRPKLQC 294
             GS+ C+    C  GY L ED   CKD DECE G H+C    + C+N +G++ C     C
Sbjct: 2225 YGSYECK----CPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI----C 2276

Query: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
              G+ +   G  C+D NEC +    C  G  C+NT GSYTC+     C  G+  +     
Sbjct: 2277 GPGYQRRPDGEGCVDENECQTKPGICENGR-CLNTRGSYTCE-----CNDGFTASPNQDE 2330

Query: 354  CVDVDE--CAPPA--EPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC------------ 397
            C+D  E  C        C  G    N      C C  G  +     +C            
Sbjct: 2331 CLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLC 2390

Query: 398  ----------VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
                       D++EC+         +C N  GSY C C  G+   + G SC D+NEC+ 
Sbjct: 2391 PHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQ 2450

Query: 448  SP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
            +P  C+  C N  GSYQC C +GY L + DG +C+D+DECA  T  H C + C+N  G F
Sbjct: 2451 APKPCNFICKNTEGSYQCSCPKGYILQE-DGRSCKDLDECA--TKQHNCQFLCVNTIGGF 2507

Query: 506  QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR-RSA 564
             C CP        +  +C D +EC + I+ C     C N  G F C   EC   +     
Sbjct: 2508 TCKCPPG---FTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTC---ECQRGFSLDQT 2561

Query: 565  ATRCERL-PCHENREC 579
             + CE +  C  N  C
Sbjct: 2562 GSSCEDVDECEGNHRC 2577



 Score =  199 bits (507), Expect = 5e-51
 Identities = 178/621 (28%), Positives = 250/621 (40%), Gaps = 126/621 (20%)

Query: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH------CATGISLANEQ-- 88
            C +G+ +A   + C      +  EC +   +C     + L       C  G SL NE+  
Sbjct: 1958 CNEGYEVAPDGRTC-----VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCE 2012

Query: 89   --DRCATPH-----GDNASLEATFVKRCCHCCLLGRAAQAQGQSCE-------YSLMVGY 134
              D C         G  ++ E +F  +C   C  G +  + G+ C+       Y+   G 
Sbjct: 2013 DIDECVEEPEICALGTCSNTEGSF--KCL--CPEGFSLSSSGRRCQDLRMSYCYAKFEGG 2068

Query: 135  QCGQVFR--------ACCVKSQETGDLDVGGLQETDKIIE---------VEEEQEDPYLN 177
            +C              C +K +  GD       E D+            +    +     
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDM 2128

Query: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C+    CK  QC +T     C C  GY L   G  C D +EC  G+  C  G +C N 
Sbjct: 2129 DECKEPDVCKHGQCINTDGSYRCECPFGYILA--GNECVDTDECSVGN-PCGNG-TCKNV 2184

Query: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            +G F C    +C  G+E     +C+DI+EC      C   F C NT GS+ C+    C  
Sbjct: 2185 IGGFEC----TCEEGFEPGPMMTCEDINECAQNPLLCA--FRCVNTYGSYECK----CPV 2234

Query: 297  GFI-QDALGNCIDINECLSISAPCPIGHT-CINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
            G++ ++    C D +EC      C      C N  G+Y C      CG GY    +G  C
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCI-----CGPGYQRRPDGEGC 2289

Query: 355  VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY-----------------YFDGISRMC 397
            VD +EC      C  G RC+N+ GS+ CEC  G+                 + + +  MC
Sbjct: 2290 VDENECQTKPGICENG-RCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMC 2348

Query: 398  ---------VDVNECQRYPGRLCGHKCE------NTLGSYLCSCSVGFRLSVDGRSCEDI 442
                     V  +EC    GR  G  CE            LC    GF  +       DI
Sbjct: 2349 QIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG-----ADI 2403

Query: 443  NECS--SSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI 499
            +EC      C   EC N  GSY C C+ GY   D+ G +C D++EC        C++ C 
Sbjct: 2404 DECKVIHDVCRNGECVNDRGSYHCICKTGYT-PDITGTSCVDLNECN--QAPKPCNFICK 2460

Query: 500  NIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPEN 559
            N  GS+QCSCP  GY L  +GR+C+D+DEC T  HNC     C N  GGF C   +CP  
Sbjct: 2461 NTEGSYQCSCPK-GYILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTC---KCPPG 2514

Query: 560  YRRSAATRCERLPCHENRECS 580
            + +          C +N EC+
Sbjct: 2515 FTQ------HHTSCIDNNECT 2529



 Score =  199 bits (505), Expect = 9e-51
 Identities = 149/515 (28%), Positives = 224/515 (43%), Gaps = 72/515 (13%)

Query: 166  EVEEEQEDPYLNDRC-----RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNE 219
            ++     +P     C     RG GP  + C   G       C  G   +++G    D++E
Sbjct: 2349 QIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGA---DIDE 2405

Query: 220  CITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPD 276
            C      CR GE C+N  GS+ C     C TGY  T D    SC D++EC      C  +
Sbjct: 2406 CKVIHDVCRNGE-CVNDRGSYHC----ICKTGY--TPDITGTSCVDLNECNQAPKPC--N 2456

Query: 277  FICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
            FIC+NT GS++C     C  G+I    G +C D++EC +    C     C+NT G +TC+
Sbjct: 2457 FICKNTEGSYQC----SCPKGYILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTCK 2510

Query: 336  KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISR 395
                 C  G+   +  T C+D +EC      CG    C N+PGSF CEC+ G+  D    
Sbjct: 2511 -----CPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGS 2563

Query: 396  MCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQE 453
             C DV+EC+      C H C+N +G Y CSC  G+        C D NEC S+       
Sbjct: 2564 SCEDVDECE--GNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS 2621

Query: 454  CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSG 513
            C N  GSY+C C  G+Q     G  C+DI+EC   +    CSY C N  G + C CP   
Sbjct: 2622 CHNTLGSYKCMCPAGFQYEQFSG-GCQDINECG--SAQAPCSYGCSNTEGGYLCGCPPGY 2678

Query: 514  YRLAPNGRNCQDIDECVTGIH----------NCSINETCFNIQGGFRCLAFECPENYRRS 563
            +R+            CV+G+           +  +++   + +  + C     P+  R+ 
Sbjct: 2679 FRIGQG--------HCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECKINGYPKRGRKR 2730

Query: 564  AATRCERLPCHENRECSKLPLRITYYHLS----FPTNI---QAPAVVFRMGPSSAVPGDS 616
             +T        E++  ++  + +  + +     F  NI        +  + P+     + 
Sbjct: 2731 RSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILELLPALTTLTNH 2790

Query: 617  MQLAITGGNEEGFFTTRKVSPHSGVVAL--TKPVP 649
             +  I  GNE+GFF   K++   G+  L  TK  P
Sbjct: 2791 NRYLIESGNEDGFF---KINQKEGISYLHFTKKKP 2822



 Score =  194 bits (492), Expect = 3e-49
 Identities = 151/487 (31%), Positives = 213/487 (43%), Gaps = 79/487 (16%)

Query: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIE 166
            K CC    +GRA     + C             F   C   +    +D+     T   ++
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPST------DEFATLCGSQRPGFVIDI----YTGLPVD 1766

Query: 167  VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
            ++E +E P +   C  G      C +      C C VG+      + CED++EC  G   
Sbjct: 1767 IDECREIPGV---CENG-----VCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGP-V 1817

Query: 227  CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
            C+    CINT GS+RC     C  GY  T    C D +EC+  I N      C +T+GSF
Sbjct: 1818 CQRNAECINTAGSYRCD----CKPGYRFTSTGQCNDRNECQE-IPNICSHGQCIDTVGSF 1872

Query: 287  RCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY 345
             C     C +GF   D    C+DINEC   +  C  G TC NT GS+ C+     C  G+
Sbjct: 1873 YCL----CHTGFKTNDDQTMCLDINECERDA--CGNG-TCRNTIGSFNCR-----CNHGF 1920

Query: 346  HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR 405
             L+     C+DVDECA       +  +C+N+ GSF+C+C  GY      R CVD+NEC  
Sbjct: 1921 ILSHNND-CIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLL 1979

Query: 406  YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS-QECANVYGSYQ 462
             P +     C+N  GSY C C  G+  S+    CEDI+EC   P  C+   C+N  GS++
Sbjct: 1980 EPRKCAPGTCQNLDGSYRCICPPGY--SLQNEKCEDIDECVEEPEICALGTCSNTEGSFK 2037

Query: 463  CYCRRGYQLSDVDGVTCEDI-----------DECALP-TGGHICSYRCINIPG------- 503
            C C  G+ LS   G  C+D+            +C+ P +  H     C  + G       
Sbjct: 2038 CLCPEGFSLSS-SGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPC 2096

Query: 504  ---------SFQCSCP-SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
                     +F+  CP  SG  + P+  +  D+DEC     +   +  C N  G +RC  
Sbjct: 2097 ELCPTEPDEAFRQICPYGSGIIVGPDD-SAVDMDECKE--PDVCKHGQCINTDGSYRC-- 2151

Query: 554  FECPENY 560
             ECP  Y
Sbjct: 2152 -ECPFGY 2157



 Score =  181 bits (458), Expect = 3e-45
 Identities = 161/540 (29%), Positives = 219/540 (40%), Gaps = 141/540 (26%)

Query: 127 EYSLMVGYQC--GQVFR---ACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCR 181
           +Y  +V Y C  G+      +C  +  +   LD+ G     + I+V+E +++P     C 
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRG-----ECIDVDECEKNP-----CA 500

Query: 182 GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFR 241
           GG     +C +      C C  GYQ       C D++EC+     C  G  CINT GSF 
Sbjct: 501 GG-----ECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR-CINTDGSFH 554

Query: 242 CQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ 300
           C     C  G+ +T D  +C+D+DEC   I N   + +C N  GSF+C     CK GF  
Sbjct: 555 C----VCNAGFHVTRDGKNCEDMDEC--SIRNMCLNGMCINEDGSFKC----ICKPGFQL 604

Query: 301 DALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV-- 357
            + G  C DINEC      C  G  C+NT+GSY C+     C  G  +  +G  CVD   
Sbjct: 605 ASDGRYCKDINEC-ETPGICMNGR-CVNTDGSYRCE-----CFPGLAVGLDGRVCVDTHM 657

Query: 358 -----------------------DEC---------APPAEPC--------------GKG- 370
                                   EC           P +PC              G G 
Sbjct: 658 RSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGM 717

Query: 371 -------HRCVNSP------------GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
                  + C   P            G+++C C +GY  D   + CVD+NEC      LC
Sbjct: 718 TSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECV-LNSLLC 776

Query: 412 GH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC-SQECANVYGSYQCYCRRGY 469
            + +C NT GS++C+C  GF    D ++CEDI+EC SSPC +  C N  GS+ C C    
Sbjct: 777 DNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSES 836

Query: 470 QLSDVDGVTCEDIDECALPTGGHICSYRC-INIPG-SFQCSCPSS--------------- 512
            L     +  E I      T   +   RC INI G + +  C SS               
Sbjct: 837 TLDPTKTICIETIKGTCWQT---VIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVD 893

Query: 513 -----GYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATR 567
                GY     G  C+DIDEC      C  N  C N +G F+C   +CP      A  R
Sbjct: 894 PICGKGYSRI-KGTQCEDIDECEVFPGVCK-NGLCVNTRGSFKC---QCPSGMTLDATGR 948



 Score =  177 bits (449), Expect = 3e-44
 Identities = 148/490 (30%), Positives = 198/490 (40%), Gaps = 125/490 (25%)

Query: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
            C +      C C  GY++ S G +C D+NEC+  S  C  G+ C NT GSF C    +C 
Sbjct: 739  CENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ-CRNTPGSFVC----TCP 793

Query: 250  TGYELTED-NSCKDIDECESG------IHNCLPDFICQ---------------------- 280
             G+    D  +C+DIDECES         N    FIC+                      
Sbjct: 794  KGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTC 853

Query: 281  -NTLGSFRCRPKLQ----------------------------CKSGFIQDALGNCIDINE 311
              T+   RC   +                             C  G+ +     C DI+E
Sbjct: 854  WQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDE 913

Query: 312  CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV-----------DEC 360
            C      C  G  C+NT GS+ CQ     C  G  L+  G  C+D+           +EC
Sbjct: 914  CEVFPGVCKNG-LCVNTRGSFKCQ-----CPSGMTLDATGRICLDIRLETCFLRYEDEEC 967

Query: 361  APPAEPCGKGHRCVNSPGSF----RCE-------------CKTGYYF-----DGISRMCV 398
              P     +   C  S G+      CE             C  G  F             
Sbjct: 968  TLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFK 1027

Query: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQ-EC 454
            D+NEC+  P  LC H KC NT+GS+ C C  GF L  + R+C DI+EC  SP  C + +C
Sbjct: 1028 DINECKMIPS-LCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQC 1086

Query: 455  ANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC----ALPTGGHICSYRCINIPGSFQCSCP 510
             N  G ++C C  GY+   +    C DIDEC     L  GG      C N  GS++C CP
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGG-----VCHNTEGSYRCECP 1141

Query: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCER 570
              G++L+PN   C DI+EC    H C  N  C N+ G ++C    C   Y  +     +R
Sbjct: 1142 -PGHQLSPNISACIDINECELSAHLCP-NGRCVNLIGKYQC---ACNPGYHSTP----DR 1192

Query: 571  LPCHENRECS 580
            L C +  ECS
Sbjct: 1193 LFCVDIDECS 1202



 Score =  103 bits (258), Expect = 4e-22
 Identities = 85/302 (28%), Positives = 112/302 (37%), Gaps = 64/302 (21%)

Query: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCI 234
           + N RC  GG C            C C  GY     G  C        G   C  G  C+
Sbjct: 118 HCNIRCMNGGSCSDDH--------CLCQKGYI----GTHC--------GQPVCESG--CL 155

Query: 235 NTVGSFRCQRDSSCGTGYELTEDNSCKDI--DECESGIHNCLPDFICQNTLGSFRCRPKL 292
           N     RC   + C   Y  T     +D     C + I N +    CQ  L    C   L
Sbjct: 156 N---GGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQM----CQGQLSGIVCTKTL 208

Query: 293 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352
            C +  +  A G+            PC +            C      C RG+  N    
Sbjct: 209 CCAT--VGRAWGH------------PCEM------------CPAQPHPCRRGFIPNIRTG 242

Query: 353 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412
            C DVDEC      C +G  C+N+ GSF C+C  G+  + +S+ C D++EC   PG   G
Sbjct: 243 ACQDVDECQAIPGLC-QGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEG 301

Query: 413 HKCENTLGSYLCSCSVGFRLSVDGRSCEDI------NECSSSPCSQECANVYGSYQCYCR 466
            +C NT+ SY C C  GF  S DG  C D+         ++  CS +        QC C 
Sbjct: 302 GECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCD 361

Query: 467 RG 468
            G
Sbjct: 362 AG 363



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 86/284 (30%), Positives = 125/284 (44%), Gaps = 51/284 (17%)

Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
           IC+++ G   C RP +  C SG I  + G+   I  C   +  C  G +C  ++    CQ
Sbjct: 84  ICRHSCGDGFCSRPNMCTCPSGQIAPSCGSR-SIQHC---NIRCMNGGSC--SDDHCLCQ 137

Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC----KTGYYFD 391
           K       G  + E G  C++   C  P       +RC  + G    +C    +TG  F 
Sbjct: 138 KGYIGTHCGQPVCESG--CLNGGRCVAP-------NRCACTYGFTGPQCERDYRTGPCFT 188

Query: 392 GIS-RMC--------VDVNECQRYPGRLCGHKCENTLGSYLCS-----CSVGFRLSVDGR 437
            IS +MC             C    GR  GH CE      +C      C  GF  ++   
Sbjct: 189 VISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE------MCPAQPHPCRRGFIPNIRTG 242

Query: 438 SCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
           +C+D++EC + P  C    C N  GS++C C  G++L++V    CEDIDEC+   G  IC
Sbjct: 243 ACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEV-SQKCEDIDECSTIPG--IC 299

Query: 495 -SYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI--DECVTGIHN 535
               C N   S+ C CP  G+  +P+G  C D+    C T + N
Sbjct: 300 EGGECTNTVSSYFCKCP-PGFYTSPDGTRCIDVRPGYCYTALTN 342


>gi|86788132 EGF-containing fibulin-like extracellular matrix
           protein 1 precursor [Homo sapiens]
          Length = 493

 Score =  241 bits (614), Expect = 2e-63
 Identities = 158/476 (33%), Positives = 228/476 (47%), Gaps = 56/476 (11%)

Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
           + C  GYE       CKDIDEC+     C     C N  G + C PK           Q 
Sbjct: 27  TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86

Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
           ++   +   G    +    S+             SA    G        ++  ++N    
Sbjct: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146

Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
             +P+       C  GY  +E    C D+DEC      C     C+N  GSF C+C  GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205

Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
              G    CVD++EC   P   C  +C NT GS+ C CS GF+L+ +  +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261

Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
           + C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC   T  ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318

Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE-CPENYRRSAAT 566
            CP  GY++    R CQDI+EC T  + C  +E C+N  GGFRC     C + Y  +   
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPEN 375

Query: 567 RCERLPCH-ENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGN 625
           RC    C   N  C +LP  I Y ++S  ++   P+ +F++  ++          I  GN
Sbjct: 376 RCV---CPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGN 432

Query: 626 EEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DLSRHGTV-SSFVAKLFIFV 679
           E G F  R+ SP S ++ L K +  PR+ ++ ++M  +S  GT  +S V +L I V
Sbjct: 433 ENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIV 488



 Score =  139 bits (350), Expect = 9e-33
 Identities = 99/299 (33%), Positives = 125/299 (41%), Gaps = 76/299 (25%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
           C  GY+     V C+D++EC  G+H+CR  + CIN  GSF CQ    C  GY+      C
Sbjct: 159 CAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQ----CPPGYQ-KRGEQC 212

Query: 261 KDIDECESGIHNCLPDFI---CQNTLGSFRCRPKLQCKSGFIQDALGN--CIDINECLSI 315
            DIDEC       +P +    C NT GSF C    QC  GF Q A  N  C+DINEC   
Sbjct: 213 VDIDEC------TIPPYCHQRCVNTPGSFYC----QCSPGF-QLAANNYTCVDINEC--- 258

Query: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
            A       C N  GS+ CQ     C +GY L+ +   C D+DEC   +  C   ++CVN
Sbjct: 259 DASNQCAQQCYNILGSFICQ-----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVN 311

Query: 376 SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435
            PG F C C  GY     SR C D+NE                                 
Sbjct: 312 EPGKFSCMCPQGYQVVR-SRTCQDINE--------------------------------- 337

Query: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
              CE  NEC      + C N +G ++CY R   Q    D       + C  P    +C
Sbjct: 338 ---CETTNECRE---DEMCWNYHGGFRCYPRNPCQ----DPYILTPENRCVCPVSNAMC 386



 Score =  100 bits (248), Expect = 6e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272

Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322

Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378


>gi|86788015 EGF-containing fibulin-like extracellular matrix
           protein 1 precursor [Homo sapiens]
          Length = 493

 Score =  241 bits (614), Expect = 2e-63
 Identities = 158/476 (33%), Positives = 228/476 (47%), Gaps = 56/476 (11%)

Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
           + C  GYE       CKDIDEC+     C     C N  G + C PK           Q 
Sbjct: 27  TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86

Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
           ++   +   G    +    S+             SA    G        ++  ++N    
Sbjct: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146

Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
             +P+       C  GY  +E    C D+DEC      C     C+N  GSF C+C  GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205

Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
              G    CVD++EC   P   C  +C NT GS+ C CS GF+L+ +  +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261

Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
           + C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC   T  ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318

Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE-CPENYRRSAAT 566
            CP  GY++    R CQDI+EC T  + C  +E C+N  GGFRC     C + Y  +   
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPEN 375

Query: 567 RCERLPCH-ENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGN 625
           RC    C   N  C +LP  I Y ++S  ++   P+ +F++  ++          I  GN
Sbjct: 376 RCV---CPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGN 432

Query: 626 EEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DLSRHGTV-SSFVAKLFIFV 679
           E G F  R+ SP S ++ L K +  PR+ ++ ++M  +S  GT  +S V +L I V
Sbjct: 433 ENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIV 488



 Score =  139 bits (350), Expect = 9e-33
 Identities = 99/299 (33%), Positives = 125/299 (41%), Gaps = 76/299 (25%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
           C  GY+     V C+D++EC  G+H+CR  + CIN  GSF CQ    C  GY+      C
Sbjct: 159 CAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQ----CPPGYQ-KRGEQC 212

Query: 261 KDIDECESGIHNCLPDFI---CQNTLGSFRCRPKLQCKSGFIQDALGN--CIDINECLSI 315
            DIDEC       +P +    C NT GSF C    QC  GF Q A  N  C+DINEC   
Sbjct: 213 VDIDEC------TIPPYCHQRCVNTPGSFYC----QCSPGF-QLAANNYTCVDINEC--- 258

Query: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
            A       C N  GS+ CQ     C +GY L+ +   C D+DEC   +  C   ++CVN
Sbjct: 259 DASNQCAQQCYNILGSFICQ-----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVN 311

Query: 376 SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435
            PG F C C  GY     SR C D+NE                                 
Sbjct: 312 EPGKFSCMCPQGYQVVR-SRTCQDINE--------------------------------- 337

Query: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
              CE  NEC      + C N +G ++CY R   Q    D       + C  P    +C
Sbjct: 338 ---CETTNECRE---DEMCWNYHGGFRCYPRNPCQ----DPYILTPENRCVCPVSNAMC 386



 Score =  100 bits (248), Expect = 6e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272

Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322

Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378


>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
           1 precursor [Homo sapiens]
          Length = 493

 Score =  241 bits (614), Expect = 2e-63
 Identities = 158/476 (33%), Positives = 228/476 (47%), Gaps = 56/476 (11%)

Query: 246 SSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL----------QC 294
           + C  GYE       CKDIDEC+     C     C N  G + C PK           Q 
Sbjct: 27  TQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86

Query: 295 KSGFIQDALGNCIDINECLSI-------------SAPCPIGHTCINTEGSYTCQKN---- 337
           ++   +   G    +    S+             SA    G        ++  ++N    
Sbjct: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146

Query: 338 --VPN-------CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY 388
             +P+       C  GY  +E    C D+DEC      C     C+N  GSF C+C  GY
Sbjct: 147 QRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205

Query: 389 YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC-SS 447
              G    CVD++EC   P   C  +C NT GS+ C CS GF+L+ +  +C DINEC +S
Sbjct: 206 QKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261

Query: 448 SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC 507
           + C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC   T  ++C Y+C+N PG F C
Sbjct: 262 NQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDECR--TSSYLCQYQCVNEPGKFSC 318

Query: 508 SCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE-CPENYRRSAAT 566
            CP  GY++    R CQDI+EC T  + C  +E C+N  GGFRC     C + Y  +   
Sbjct: 319 MCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPEN 375

Query: 567 RCERLPCH-ENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGN 625
           RC    C   N  C +LP  I Y ++S  ++   P+ +F++  ++          I  GN
Sbjct: 376 RCV---CPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGN 432

Query: 626 EEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DLSRHGTV-SSFVAKLFIFV 679
           E G F  R+ SP S ++ L K +  PR+ ++ ++M  +S  GT  +S V +L I V
Sbjct: 433 ENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIV 488



 Score =  139 bits (350), Expect = 9e-33
 Identities = 99/299 (33%), Positives = 125/299 (41%), Gaps = 76/299 (25%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
           C  GY+     V C+D++EC  G+H+CR  + CIN  GSF CQ    C  GY+      C
Sbjct: 159 CAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQ----CPPGYQ-KRGEQC 212

Query: 261 KDIDECESGIHNCLPDFI---CQNTLGSFRCRPKLQCKSGFIQDALGN--CIDINECLSI 315
            DIDEC       +P +    C NT GSF C    QC  GF Q A  N  C+DINEC   
Sbjct: 213 VDIDEC------TIPPYCHQRCVNTPGSFYC----QCSPGF-QLAANNYTCVDINEC--- 258

Query: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375
            A       C N  GS+ CQ     C +GY L+ +   C D+DEC   +  C   ++CVN
Sbjct: 259 DASNQCAQQCYNILGSFICQ-----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVN 311

Query: 376 SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435
            PG F C C  GY     SR C D+NE                                 
Sbjct: 312 EPGKFSCMCPQGYQVVR-SRTCQDINE--------------------------------- 337

Query: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
              CE  NEC      + C N +G ++CY R   Q    D       + C  P    +C
Sbjct: 338 ---CETTNECRE---DEMCWNYHGGFRCYPRNPCQ----DPYILTPENRCVCPVSNAMC 386



 Score =  100 bits (248), Expect = 6e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272

Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322

Query: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  239 bits (611), Expect = 5e-63
 Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T     C C +G+Q  + G  CEDV+EC   +H    G+ C+N
Sbjct: 687  DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 744

Query: 236  TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
            + GSF+C+   +C +G+ L     C D+DEC SG   C P   C NT GSFRC   P  +
Sbjct: 745  SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800

Query: 294  CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
              SG      G C D+NECL      P G  C+NT+GS+ C      C  GY     G  
Sbjct: 801  APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 850

Query: 354  CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
            C+DVDEC+   + C  G  C N+ GSF C C  G+        C+DV+EC+     LCG 
Sbjct: 851  CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 908

Query: 413  HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
             +CEN+ GSY C   C  G+    +G +C+D++EC       C +Q C N  GSY+C   
Sbjct: 909  QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 967

Query: 465  CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
            C  GYQ +   G  C+D+DEC   +  G H     C N+PGSFQC C   GY  A +GR+
Sbjct: 968  CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1021

Query: 523  CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
            C D++EC T    C     C N++G F C+    PE +
Sbjct: 1022 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1058



 Score =  224 bits (570), Expect = 3e-58
 Identities = 160/459 (34%), Positives = 207/459 (45%), Gaps = 73/459 (15%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T    +C C  GYQ    G SC+DV+EC      C  G +C N
Sbjct: 564  DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 622

Query: 236  TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
              GSFRC                   Q    CG G       S                 
Sbjct: 623  LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 682

Query: 260  CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
            C+D+DEC      C     C+NT GSF+C     C  GF  +  G+ C D++EC +  A 
Sbjct: 683  CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 736

Query: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
            CP G  C+N+ GS+ C+     C  G+HL+    RC DVDEC+  A PCG    C N+ G
Sbjct: 737  CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 789

Query: 379  SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
            SFRC C  GY    G    C DVNEC          +C NT GS+ C+C+ G+R    G 
Sbjct: 790  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 849

Query: 438  SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC- 494
            SC D++ECS     Q   C N  GS++C C  G++ +  D  +C D+DEC    G  +C 
Sbjct: 850  SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECR-ERGPALCG 907

Query: 495  SYRCINIPGSFQC--SCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGFRC 551
            S RC N PGS++C   C   GY   P G  C D+DEC   G   C   + C N  G +RC
Sbjct: 908  SQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVDECQEYGPEICGA-QRCENTPGSYRC 964

Query: 552  LAFECPENYRRSAATRCE-------RLPCHENRECSKLP 583
                C   Y+ +    C+       R  C  +  C  LP
Sbjct: 965  TP-ACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLP 1002



 Score =  212 bits (539), Expect = 1e-54
 Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)

Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
           GP +   R +G    C+C  G++L   G  C DV+EC      C  G  C N+ GSFRC 
Sbjct: 490 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 545

Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
               CG G+        C D+DEC    H   P      C+NT GSF C     C +G+ 
Sbjct: 546 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 594

Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
               G +C D++EC      C  G  C N  GS+ C      C  G+     G+ C  DV
Sbjct: 595 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 644

Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
           DECA    PCG G RC N+ GSF C C  G+   G    C DV+EC R P      +CEN
Sbjct: 645 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 703

Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
           T GS+ C C +GF+ +  G  CED++EC +      QEC N  GS+QC  C  G+ L   
Sbjct: 704 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 760

Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
               C D+DEC   A P G H     C N  GSF+CSC + GYR AP+GR   C D++EC
Sbjct: 761 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 815

Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
           + G   C  +  C N  G F C    C   YR
Sbjct: 816 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 843



 Score =  190 bits (482), Expect = 4e-48
 Identities = 109/273 (39%), Positives = 148/273 (54%), Gaps = 34/273 (12%)

Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
           CI+    YTC      C  G+ L+ +GTRC+DVDEC     PC  G RC NSPGSFRC C
Sbjct: 494 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 547

Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
             G+     +  C+DV+EC R P      +CENT GS+LC C  G++ +  G SC+D++E
Sbjct: 548 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 607

Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
           C+ SP  C +  C N+ GS++C C  G++     G  C ED+DECA    P G      R
Sbjct: 608 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 658

Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
           C N  GSF C+CP +G+R    G  CQD+DEC      C+    C N +G F+C+   CP
Sbjct: 659 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 713

Query: 558 ENYR-RSAATRCERLPCHEN------RECSKLP 583
             ++  +A + CE +   EN      +EC   P
Sbjct: 714 MGFQPNTAGSECEDVDECENHLACPGQECVNSP 746



 Score =  145 bits (366), Expect = 1e-34
 Identities = 84/234 (35%), Positives = 115/234 (49%), Gaps = 22/234 (9%)

Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
           C    + CG G RC++ P  + C C +G+        C+DV+EC+R P      +CEN+ 
Sbjct: 482 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 540

Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
           GS+ C C  GFR       C D++EC     PC    C N  GS+ C C  GYQ +   G
Sbjct: 541 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 599

Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
            +C+D+DEC    G  +C    C N+PGSF+C CP +G+R    G  C +D+DEC     
Sbjct: 600 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 652

Query: 535 NCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITY 588
            C     C N  G F C    CP  +R    +R    PC +  EC++ P   TY
Sbjct: 653 PCGPGR-CDNTAGSFHC---ACPAGFR----SRGPGAPCQDVDECARSPPPCTY 698



 Score =  112 bits (279), Expect = 1e-24
 Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)

Query: 178  DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
            D CR  GP     Q+C ++     C   C  GY    +G +C+DV+EC          + 
Sbjct: 896  DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 954

Query: 233  CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
            C NT GS+RC    +C  GY+ T    C+D+DEC +    C    +CQN  GSF+C    
Sbjct: 955  CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1008

Query: 293  QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
             C  G+     G +C+D+NEC ++   C     C N EGS+ C    PN    +  +   
Sbjct: 1009 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1062

Query: 352  TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
             RCV     A                     PP  P           GS R EC    YF
Sbjct: 1063 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1118

Query: 391  D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
            D         I    V   EC    G   G  C        E      LC    G+   S
Sbjct: 1119 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1178

Query: 434  VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
             D     D++EC       C S  C N    Y CYC  GY       + C D DECA   
Sbjct: 1179 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1237

Query: 487  -LPTGGHICSYRCINIPGSFQCSC 509
                GG     RC+N  GS+ C+C
Sbjct: 1238 PACEGG-----RCVNTVGSYHCTC 1256



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)

Query: 308  DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
            D++EC L     C  G  C+NT   Y+C      C  GY+ + +   C+D DECA   EP
Sbjct: 1186 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1238

Query: 367  CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
              +G RCVN+ GS+ C C+     DG  R CV  NE Q     L            C H 
Sbjct: 1239 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1297

Query: 415  CENTLGSYL-CSCSVGFRLSVDGRSC 439
              +   +Y  C C  G    +D   C
Sbjct: 1298 RLDRQATYTECCCLYGEAWGMDCALC 1323



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)

Query: 342  GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
            GRGY L   G   +  DVDEC    +   K   CVN+   + C C  GYY+      C+D
Sbjct: 1171 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1229

Query: 400  VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
             +EC        G +C NT+GSY C+C     L    R C
Sbjct: 1230 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1269



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)

Query: 364  AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
            AE CG        RCV  P  F C C  GY  D     CVD+NEC        LC   +C
Sbjct: 1467 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1526

Query: 416  ENTLGSYLCSCSVGF 430
             NT GS+ C C  GF
Sbjct: 1527 LNTDGSFRCICRPGF 1541



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)

Query: 307  IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
            ++  EC  I   C  G  C+     +TC+     C  GY L+     CVD++EC  A  A
Sbjct: 1465 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1517

Query: 365  EPCGKGHRCVNSPGSFRCECKTGY 388
             P     RC+N+ GSFRC C+ G+
Sbjct: 1518 SPLCVNARCLNTDGSFRCICRPGF 1541



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)

Query: 459  GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
            GSY       Y+  +++   C  +D C   T G     RC+ +P  F C C   GYRL  
Sbjct: 1452 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1500

Query: 519  NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
                C DI+EC          +N  C N  G FRC+
Sbjct: 1501 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 398  VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
            ++  EC    G   G +C      + C C  G+RL +   +C DINEC    ++SP   +
Sbjct: 1465 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 452  QECANVYGSYQCYCRRGY 469
              C N  GS++C CR G+
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
            E E E+  + D C  G     +C    +   C CF GY+L    ++C D+NEC     + 
Sbjct: 1464 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1518

Query: 228  RL--GESCINTVGSFRC 242
             L     C+NT GSFRC
Sbjct: 1519 PLCVNARCLNTDGSFRC 1535



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)

Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
           V +C   +E  G   R V++P      C TG  F+ ++  C DV+EC    G  C H +C
Sbjct: 254 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 305

Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
            NT G Y C C  GF L     SC  + +   +  PC
Sbjct: 306 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 342



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)

Query: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
            GSY  S +  +   ++   C  ++ C++      C  V   + C C  GY+L D+  + C
Sbjct: 1452 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1505

Query: 480  EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
             DI+EC        +C + RC+N  GSF+C C
Sbjct: 1506 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1537



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)

Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
           G+H+C    +C   LG+      P   C +GF +   G+C D++EC +    C  G  C 
Sbjct: 253 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 306

Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
           NT G YTC      C  G+ L+   + C+     +    PC
Sbjct: 307 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 342



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)

Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
           G H C+L   C   +G+       D  C TG+E   + SC+D+DEC +G         C 
Sbjct: 253 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 306

Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
           NT G + C     C  GF+ D +  +CI  +       PC
Sbjct: 307 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 342



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 261  KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
            +D+DEC+          +C NT   + C     C +G+        CID +EC      C
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1240

Query: 320  PIGHTCINTEGSYTCQKNVP 339
              G  C+NT GSY C    P
Sbjct: 1241 E-GGRCVNTVGSYHCTCEPP 1259



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)

Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
           V++CQ     LC  +  N+  + +    C  GF   V+G SCED++EC++    Q  ECA
Sbjct: 254 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 306

Query: 456 NVYGSYQCYCRRGYQL 471
           N  G Y C C  G+ L
Sbjct: 307 NTRGGYTCVCPDGFLL 322



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)

Query: 252  YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
            YE  E   C  +D C +G         C      F CR    C  G+  D     C+DIN
Sbjct: 1462 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1509

Query: 311  ECLSISAPCP--IGHTCINTEGSYTC 334
            EC    A  P  +   C+NT+GS+ C
Sbjct: 1510 ECDEAEAASPLCVNARCLNTDGSFRC 1535



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)

Query: 112  CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
            CC +G   +  G  C      G +  + +++ C   +  G L   G    D  +  + ++
Sbjct: 1140 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1189

Query: 172  EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
               + +  C+ G      C +T     C C  GY   +  + C D +EC     +C  G 
Sbjct: 1190 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1243

Query: 232  SCINTVGSFRC 242
             C+NTVGS+ C
Sbjct: 1244 RCVNTVGSYHC 1254



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)

Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
           S+P     ++  G   C+   R G   S + G+  +++      L  G H C      + 
Sbjct: 206 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 265

Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
            S + S     CP+   R+  NG +C+D+DEC TG   C   E C N +GG+ C+   CP
Sbjct: 266 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 317

Query: 558 ENY 560
           + +
Sbjct: 318 DGF 320



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
           C  G++ ++   SCEDV+EC TG   C+ GE C NT G + C     C  G+ L    S
Sbjct: 277 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 327


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  239 bits (611), Expect = 5e-63
 Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T     C C +G+Q  + G  CEDV+EC   +H    G+ C+N
Sbjct: 717  DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 774

Query: 236  TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
            + GSF+C+   +C +G+ L     C D+DEC SG   C P   C NT GSFRC   P  +
Sbjct: 775  SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 830

Query: 294  CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
              SG      G C D+NECL      P G  C+NT+GS+ C      C  GY     G  
Sbjct: 831  APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 880

Query: 354  CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
            C+DVDEC+   + C  G  C N+ GSF C C  G+        C+DV+EC+     LCG 
Sbjct: 881  CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 938

Query: 413  HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
             +CEN+ GSY C   C  G+    +G +C+D++EC       C +Q C N  GSY+C   
Sbjct: 939  QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 997

Query: 465  CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
            C  GYQ +   G  C+D+DEC   +  G H     C N+PGSFQC C   GY  A +GR+
Sbjct: 998  CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1051

Query: 523  CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
            C D++EC T    C     C N++G F C+    PE +
Sbjct: 1052 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1088



 Score =  224 bits (570), Expect = 3e-58
 Identities = 160/459 (34%), Positives = 207/459 (45%), Gaps = 73/459 (15%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T    +C C  GYQ    G SC+DV+EC      C  G +C N
Sbjct: 594  DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 652

Query: 236  TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
              GSFRC                   Q    CG G       S                 
Sbjct: 653  LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 712

Query: 260  CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
            C+D+DEC      C     C+NT GSF+C     C  GF  +  G+ C D++EC +  A 
Sbjct: 713  CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 766

Query: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
            CP G  C+N+ GS+ C+     C  G+HL+    RC DVDEC+  A PCG    C N+ G
Sbjct: 767  CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 819

Query: 379  SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
            SFRC C  GY    G    C DVNEC          +C NT GS+ C+C+ G+R    G 
Sbjct: 820  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 879

Query: 438  SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC- 494
            SC D++ECS     Q   C N  GS++C C  G++ +  D  +C D+DEC    G  +C 
Sbjct: 880  SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECR-ERGPALCG 937

Query: 495  SYRCINIPGSFQC--SCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGFRC 551
            S RC N PGS++C   C   GY   P G  C D+DEC   G   C   + C N  G +RC
Sbjct: 938  SQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVDECQEYGPEICGA-QRCENTPGSYRC 994

Query: 552  LAFECPENYRRSAATRCE-------RLPCHENRECSKLP 583
                C   Y+ +    C+       R  C  +  C  LP
Sbjct: 995  TP-ACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLP 1032



 Score =  212 bits (539), Expect = 1e-54
 Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)

Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
           GP +   R +G    C+C  G++L   G  C DV+EC      C  G  C N+ GSFRC 
Sbjct: 520 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 575

Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
               CG G+        C D+DEC    H   P      C+NT GSF C     C +G+ 
Sbjct: 576 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 624

Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
               G +C D++EC      C  G  C N  GS+ C      C  G+     G+ C  DV
Sbjct: 625 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 674

Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
           DECA    PCG G RC N+ GSF C C  G+   G    C DV+EC R P      +CEN
Sbjct: 675 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 733

Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
           T GS+ C C +GF+ +  G  CED++EC +      QEC N  GS+QC  C  G+ L   
Sbjct: 734 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 790

Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
               C D+DEC   A P G H     C N  GSF+CSC + GYR AP+GR   C D++EC
Sbjct: 791 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 845

Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
           + G   C  +  C N  G F C    C   YR
Sbjct: 846 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 873



 Score =  190 bits (482), Expect = 4e-48
 Identities = 109/273 (39%), Positives = 148/273 (54%), Gaps = 34/273 (12%)

Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
           CI+    YTC      C  G+ L+ +GTRC+DVDEC     PC  G RC NSPGSFRC C
Sbjct: 524 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 577

Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
             G+     +  C+DV+EC R P      +CENT GS+LC C  G++ +  G SC+D++E
Sbjct: 578 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 637

Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
           C+ SP  C +  C N+ GS++C C  G++     G  C ED+DECA    P G      R
Sbjct: 638 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 688

Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
           C N  GSF C+CP +G+R    G  CQD+DEC      C+    C N +G F+C+   CP
Sbjct: 689 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 743

Query: 558 ENYR-RSAATRCERLPCHEN------RECSKLP 583
             ++  +A + CE +   EN      +EC   P
Sbjct: 744 MGFQPNTAGSECEDVDECENHLACPGQECVNSP 776



 Score =  145 bits (366), Expect = 1e-34
 Identities = 84/234 (35%), Positives = 115/234 (49%), Gaps = 22/234 (9%)

Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
           C    + CG G RC++ P  + C C +G+        C+DV+EC+R P      +CEN+ 
Sbjct: 512 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 570

Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
           GS+ C C  GFR       C D++EC     PC    C N  GS+ C C  GYQ +   G
Sbjct: 571 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 629

Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
            +C+D+DEC    G  +C    C N+PGSF+C CP +G+R    G  C +D+DEC     
Sbjct: 630 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 682

Query: 535 NCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITY 588
            C     C N  G F C    CP  +R    +R    PC +  EC++ P   TY
Sbjct: 683 PCGPGR-CDNTAGSFHC---ACPAGFR----SRGPGAPCQDVDECARSPPPCTY 728



 Score =  112 bits (279), Expect = 1e-24
 Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)

Query: 178  DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
            D CR  GP     Q+C ++     C   C  GY    +G +C+DV+EC          + 
Sbjct: 926  DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 984

Query: 233  CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
            C NT GS+RC    +C  GY+ T    C+D+DEC +    C    +CQN  GSF+C    
Sbjct: 985  CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1038

Query: 293  QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
             C  G+     G +C+D+NEC ++   C     C N EGS+ C    PN    +  +   
Sbjct: 1039 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1092

Query: 352  TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
             RCV     A                     PP  P           GS R EC    YF
Sbjct: 1093 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1148

Query: 391  D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
            D         I    V   EC    G   G  C        E      LC    G+   S
Sbjct: 1149 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1208

Query: 434  VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
             D     D++EC       C S  C N    Y CYC  GY       + C D DECA   
Sbjct: 1209 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1267

Query: 487  -LPTGGHICSYRCINIPGSFQCSC 509
                GG     RC+N  GS+ C+C
Sbjct: 1268 PACEGG-----RCVNTVGSYHCTC 1286



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)

Query: 308  DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
            D++EC L     C  G  C+NT   Y+C      C  GY+ + +   C+D DECA   EP
Sbjct: 1216 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1268

Query: 367  CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
              +G RCVN+ GS+ C C+     DG  R CV  NE Q     L            C H 
Sbjct: 1269 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1327

Query: 415  CENTLGSYL-CSCSVGFRLSVDGRSC 439
              +   +Y  C C  G    +D   C
Sbjct: 1328 RLDRQATYTECCCLYGEAWGMDCALC 1353



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)

Query: 342  GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
            GRGY L   G   +  DVDEC    +   K   CVN+   + C C  GYY+      C+D
Sbjct: 1201 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1259

Query: 400  VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
             +EC        G +C NT+GSY C+C     L    R C
Sbjct: 1260 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1299



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)

Query: 364  AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
            AE CG        RCV  P  F C C  GY  D     CVD+NEC        LC   +C
Sbjct: 1497 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1556

Query: 416  ENTLGSYLCSCSVGF 430
             NT GS+ C C  GF
Sbjct: 1557 LNTDGSFRCICRPGF 1571



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)

Query: 307  IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
            ++  EC  I   C  G  C+     +TC+     C  GY L+     CVD++EC  A  A
Sbjct: 1495 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1547

Query: 365  EPCGKGHRCVNSPGSFRCECKTGY 388
             P     RC+N+ GSFRC C+ G+
Sbjct: 1548 SPLCVNARCLNTDGSFRCICRPGF 1571



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)

Query: 459  GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
            GSY       Y+  +++   C  +D C   T G     RC+ +P  F C C   GYRL  
Sbjct: 1482 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1530

Query: 519  NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
                C DI+EC          +N  C N  G FRC+
Sbjct: 1531 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 398  VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
            ++  EC    G   G +C      + C C  G+RL +   +C DINEC    ++SP   +
Sbjct: 1495 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 452  QECANVYGSYQCYCRRGY 469
              C N  GS++C CR G+
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
            E E E+  + D C  G     +C    +   C CF GY+L    ++C D+NEC     + 
Sbjct: 1494 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1548

Query: 228  RL--GESCINTVGSFRC 242
             L     C+NT GSFRC
Sbjct: 1549 PLCVNARCLNTDGSFRC 1565



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)

Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
           V +C   +E  G   R V++P      C TG  F+ ++  C DV+EC    G  C H +C
Sbjct: 284 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 335

Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
            NT G Y C C  GF L     SC  + +   +  PC
Sbjct: 336 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 372



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)

Query: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
            GSY  S +  +   ++   C  ++ C++      C  V   + C C  GY+L D+  + C
Sbjct: 1482 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1535

Query: 480  EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
             DI+EC        +C + RC+N  GSF+C C
Sbjct: 1536 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1567



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)

Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
           G+H+C    +C   LG+      P   C +GF +   G+C D++EC +    C  G  C 
Sbjct: 283 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 336

Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
           NT G YTC      C  G+ L+   + C+     +    PC
Sbjct: 337 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 372



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)

Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
           G H C+L   C   +G+       D  C TG+E   + SC+D+DEC +G         C 
Sbjct: 283 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 336

Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
           NT G + C     C  GF+ D +  +CI  +       PC
Sbjct: 337 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 372



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 261  KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
            +D+DEC+          +C NT   + C     C +G+        CID +EC      C
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1270

Query: 320  PIGHTCINTEGSYTCQKNVP 339
              G  C+NT GSY C    P
Sbjct: 1271 E-GGRCVNTVGSYHCTCEPP 1289



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)

Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
           V++CQ     LC  +  N+  + +    C  GF   V+G SCED++EC++    Q  ECA
Sbjct: 284 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 336

Query: 456 NVYGSYQCYCRRGYQL 471
           N  G Y C C  G+ L
Sbjct: 337 NTRGGYTCVCPDGFLL 352



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)

Query: 252  YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
            YE  E   C  +D C +G         C      F CR    C  G+  D     C+DIN
Sbjct: 1492 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1539

Query: 311  ECLSISAPCP--IGHTCINTEGSYTC 334
            EC    A  P  +   C+NT+GS+ C
Sbjct: 1540 ECDEAEAASPLCVNARCLNTDGSFRC 1565



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)

Query: 112  CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
            CC +G   +  G  C      G +  + +++ C   +  G L   G    D  +  + ++
Sbjct: 1170 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1219

Query: 172  EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
               + +  C+ G      C +T     C C  GY   +  + C D +EC     +C  G 
Sbjct: 1220 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1273

Query: 232  SCINTVGSFRC 242
             C+NTVGS+ C
Sbjct: 1274 RCVNTVGSYHC 1284



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)

Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
           S+P     ++  G   C+   R G   S + G+  +++      L  G H C      + 
Sbjct: 236 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 295

Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
            S + S     CP+   R+  NG +C+D+DEC TG   C   E C N +GG+ C+   CP
Sbjct: 296 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 347

Query: 558 ENY 560
           + +
Sbjct: 348 DGF 350



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
           C  G++ ++   SCEDV+EC TG   C+ GE C NT G + C     C  G+ L    S
Sbjct: 307 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 357


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  239 bits (611), Expect = 5e-63
 Identities = 153/398 (38%), Positives = 205/398 (51%), Gaps = 41/398 (10%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T     C C +G+Q  + G  CEDV+EC   +H    G+ C+N
Sbjct: 754  DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC--ENHLACPGQECVN 811

Query: 236  TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQ 293
            + GSF+C+   +C +G+ L     C D+DEC SG   C P   C NT GSFRC   P  +
Sbjct: 812  SPGSFQCR---TCPSGHHLHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 867

Query: 294  CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
              SG      G C D+NECL      P G  C+NT+GS+ C      C  GY     G  
Sbjct: 868  APSG----RPGPCADVNECLEGDFCFPHGE-CLNTDGSFAC-----TCAPGYRPGPRGAS 917

Query: 354  CVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG- 412
            C+DVDEC+   + C  G  C N+ GSF C C  G+        C+DV+EC+     LCG 
Sbjct: 918  CLDVDECSEE-DLCQSGI-CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 975

Query: 413  HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS---SPC-SQECANVYGSYQCY-- 464
             +CEN+ GSY C   C  G+    +G +C+D++EC       C +Q C N  GSY+C   
Sbjct: 976  QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPA 1034

Query: 465  CRRGYQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRN 522
            C  GYQ +   G  C+D+DEC   +  G H     C N+PGSFQC C   GY  A +GR+
Sbjct: 1035 CDPGYQPTPGGG--CQDVDECRNRSFCGAHAV---CQNLPGSFQCLC-DQGYEGARDGRH 1088

Query: 523  CQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
            C D++EC T    C     C N++G F C+    PE +
Sbjct: 1089 CVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEF 1125



 Score =  224 bits (570), Expect = 3e-58
 Identities = 160/459 (34%), Positives = 207/459 (45%), Gaps = 73/459 (15%)

Query: 178  DRC-RGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C R   PC   +C +T    +C C  GYQ    G SC+DV+EC      C  G +C N
Sbjct: 631  DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKN 689

Query: 236  TVGSFRC-------------------QRDSSCGTGYELTEDNS----------------- 259
              GSFRC                   Q    CG G       S                 
Sbjct: 690  LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 749

Query: 260  CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAP 318
            C+D+DEC      C     C+NT GSF+C     C  GF  +  G+ C D++EC +  A 
Sbjct: 750  CQDVDECARSPPPCTYGR-CENTEGSFQC----VCPMGFQPNTAGSECEDVDECENHLA- 803

Query: 319  CPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
            CP G  C+N+ GS+ C+     C  G+HL+    RC DVDEC+  A PCG    C N+ G
Sbjct: 804  CP-GQECVNSPGSFQCR----TCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEG 856

Query: 379  SFRCECKTGYYF-DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR 437
            SFRC C  GY    G    C DVNEC          +C NT GS+ C+C+ G+R    G 
Sbjct: 857  SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 916

Query: 438  SCEDINECSSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC- 494
            SC D++ECS     Q   C N  GS++C C  G++ +  D  +C D+DEC    G  +C 
Sbjct: 917  SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECR-ERGPALCG 974

Query: 495  SYRCINIPGSFQC--SCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGFRC 551
            S RC N PGS++C   C   GY   P G  C D+DEC   G   C   + C N  G +RC
Sbjct: 975  SQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVDECQEYGPEICGA-QRCENTPGSYRC 1031

Query: 552  LAFECPENYRRSAATRCE-------RLPCHENRECSKLP 583
                C   Y+ +    C+       R  C  +  C  LP
Sbjct: 1032 TP-ACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLP 1069



 Score =  212 bits (539), Expect = 1e-54
 Identities = 150/392 (38%), Positives = 189/392 (48%), Gaps = 52/392 (13%)

Query: 184 GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ 243
           GP +   R +G    C+C  G++L   G  C DV+EC      C  G  C N+ GSFRC 
Sbjct: 557 GPGRCISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRC- 612

Query: 244 RDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDF---ICQNTLGSFRCRPKLQCKSGFI 299
               CG G+        C D+DEC    H   P      C+NT GSF C     C +G+ 
Sbjct: 613 ---VCGPGFRAGPRAAECLDVDEC----HRVPPPCDLGRCENTPGSFLC----VCPAGYQ 661

Query: 300 QDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC-VDV 357
               G +C D++EC      C  G  C N  GS+ C      C  G+     G+ C  DV
Sbjct: 662 AAPHGASCQDVDECTQSPGLCGRG-ACKNLPGSFRCV-----CPAGF----RGSACEEDV 711

Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
           DECA    PCG G RC N+ GSF C C  G+   G    C DV+EC R P      +CEN
Sbjct: 712 DECAQEPPPCGPG-RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCEN 770

Query: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC--SQECANVYGSYQC-YCRRGYQLSDV 474
           T GS+ C C +GF+ +  G  CED++EC +      QEC N  GS+QC  C  G+ L   
Sbjct: 771 TEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--- 827

Query: 475 DGVTCEDIDEC---ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGR--NCQDIDEC 529
               C D+DEC   A P G H     C N  GSF+CSC + GYR AP+GR   C D++EC
Sbjct: 828 HRGRCTDVDECSSGAPPCGPH---GHCTNTEGSFRCSC-APGYR-APSGRPGPCADVNEC 882

Query: 530 VTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
           + G   C  +  C N  G F C    C   YR
Sbjct: 883 LEG-DFCFPHGECLNTDGSFAC---TCAPGYR 910



 Score =  190 bits (482), Expect = 4e-48
 Identities = 109/273 (39%), Positives = 148/273 (54%), Gaps = 34/273 (12%)

Query: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCEC 384
           CI+    YTC      C  G+ L+ +GTRC+DVDEC     PC  G RC NSPGSFRC C
Sbjct: 561 CISRPSGYTCA-----CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVC 614

Query: 385 KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444
             G+     +  C+DV+EC R P      +CENT GS+LC C  G++ +  G SC+D++E
Sbjct: 615 GPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE 674

Query: 445 CSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTC-EDIDECAL---PTGGHICSYR 497
           C+ SP  C +  C N+ GS++C C  G++     G  C ED+DECA    P G      R
Sbjct: 675 CTQSPGLCGRGACKNLPGSFRCVCPAGFR-----GSACEEDVDECAQEPPPCG----PGR 725

Query: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
           C N  GSF C+CP +G+R    G  CQD+DEC      C+    C N +G F+C+   CP
Sbjct: 726 CDNTAGSFHCACP-AGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCV---CP 780

Query: 558 ENYR-RSAATRCERLPCHEN------RECSKLP 583
             ++  +A + CE +   EN      +EC   P
Sbjct: 781 MGFQPNTAGSECEDVDECENHLACPGQECVNSP 813



 Score =  145 bits (366), Expect = 1e-34
 Identities = 84/234 (35%), Positives = 115/234 (49%), Gaps = 22/234 (9%)

Query: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTL 419
           C    + CG G RC++ P  + C C +G+        C+DV+EC+R P      +CEN+ 
Sbjct: 549 CQRNPQVCGPG-RCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP 607

Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECS--SSPCS-QECANVYGSYQCYCRRGYQLSDVDG 476
           GS+ C C  GFR       C D++EC     PC    C N  GS+ C C  GYQ +   G
Sbjct: 608 GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAP-HG 666

Query: 477 VTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC-QDIDECVTGIH 534
            +C+D+DEC    G  +C    C N+PGSF+C CP +G+R    G  C +D+DEC     
Sbjct: 667 ASCQDVDECTQSPG--LCGRGACKNLPGSFRCVCP-AGFR----GSACEEDVDECAQEPP 719

Query: 535 NCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITY 588
            C     C N  G F C    CP  +R    +R    PC +  EC++ P   TY
Sbjct: 720 PCGPGR-CDNTAGSFHC---ACPAGFR----SRGPGAPCQDVDECARSPPPCTY 765



 Score =  112 bits (279), Expect = 1e-24
 Identities = 114/384 (29%), Positives = 146/384 (38%), Gaps = 75/384 (19%)

Query: 178  DRCRGGGPC---KQQCRDTGDEVVC--SCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
            D CR  GP     Q+C ++     C   C  GY    +G +C+DV+EC          + 
Sbjct: 963  DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR 1021

Query: 233  CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
            C NT GS+RC    +C  GY+ T    C+D+DEC +    C    +CQN  GSF+C    
Sbjct: 1022 CENTPGSYRCT--PACDPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCL--- 1075

Query: 293  QCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
             C  G+     G +C+D+NEC ++   C     C N EGS+ C    PN    +  +   
Sbjct: 1076 -CDQGYEGARDGRHCVDVNECETLQGVCGAA-LCENVEGSFLCV--CPNSPEEF--DPMT 1129

Query: 352  TRCVDVDECA---------------------PPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
             RCV     A                     PP  P           GS R EC    YF
Sbjct: 1130 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRREC----YF 1185

Query: 391  D--------GISRMCVDVNECQRYPGRLCGHKC--------ENTLGSYLCSCSVGFRL-S 433
            D         I    V   EC    G   G  C        E      LC    G+   S
Sbjct: 1186 DTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPS 1245

Query: 434  VDGRSCEDINECS---SSPC-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA--- 486
             D     D++EC       C S  C N    Y CYC  GY       + C D DECA   
Sbjct: 1246 GDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYY-HTQRLECIDNDECADEE 1304

Query: 487  -LPTGGHICSYRCINIPGSFQCSC 509
                GG     RC+N  GS+ C+C
Sbjct: 1305 PACEGG-----RCVNTVGSYHCTC 1323



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 48/146 (32%), Positives = 63/146 (43%), Gaps = 22/146 (15%)

Query: 308  DINEC-LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
            D++EC L     C  G  C+NT   Y+C      C  GY+ + +   C+D DECA   EP
Sbjct: 1253 DVDECQLFRDQVCKSG-VCVNTAPGYSCY-----CSNGYYYHTQRLECIDNDECADE-EP 1305

Query: 367  CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRL------------CGHK 414
              +G RCVN+ GS+ C C+     DG  R CV  NE Q     L            C H 
Sbjct: 1306 ACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHP 1364

Query: 415  CENTLGSYL-CSCSVGFRLSVDGRSC 439
              +   +Y  C C  G    +D   C
Sbjct: 1365 RLDRQATYTECCCLYGEAWGMDCALC 1390



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 36/100 (36%), Positives = 46/100 (46%), Gaps = 3/100 (3%)

Query: 342  GRGYHLNEEGTRCV--DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
            GRGY L   G   +  DVDEC    +   K   CVN+   + C C  GYY+      C+D
Sbjct: 1238 GRGY-LAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECID 1296

Query: 400  VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
             +EC        G +C NT+GSY C+C     L    R C
Sbjct: 1297 NDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1336



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 31/75 (41%), Positives = 34/75 (45%), Gaps = 8/75 (10%)

Query: 364  AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR--LC-GHKC 415
            AE CG        RCV  P  F C C  GY  D     CVD+NEC        LC   +C
Sbjct: 1534 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1593

Query: 416  ENTLGSYLCSCSVGF 430
             NT GS+ C C  GF
Sbjct: 1594 LNTDGSFRCICRPGF 1608



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)

Query: 307  IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC--APPA 364
            ++  EC  I   C  G  C+     +TC+     C  GY L+     CVD++EC  A  A
Sbjct: 1532 LEAEEC-GILDGCTNGR-CVRVPEGFTCR-----CFDGYRLDMTRMACVDINECDEAEAA 1584

Query: 365  EPCGKGHRCVNSPGSFRCECKTGY 388
             P     RC+N+ GSFRC C+ G+
Sbjct: 1585 SPLCVNARCLNTDGSFRCICRPGF 1608



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 13/96 (13%)

Query: 459  GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAP 518
            GSY       Y+  +++   C  +D C   T G     RC+ +P  F C C   GYRL  
Sbjct: 1519 GSYAGSLAEPYE--ELEAEECGILDGC---TNG-----RCVRVPEGFTCRC-FDGYRLDM 1567

Query: 519  NGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCL 552
                C DI+EC          +N  C N  G FRC+
Sbjct: 1568 TRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 398  VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC----SSSP--CS 451
            ++  EC    G   G +C      + C C  G+RL +   +C DINEC    ++SP   +
Sbjct: 1532 LEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 452  QECANVYGSYQCYCRRGY 469
              C N  GS++C CR G+
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 168  EEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
            E E E+  + D C  G     +C    +   C CF GY+L    ++C D+NEC     + 
Sbjct: 1531 ELEAEECGILDGCTNG-----RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1585

Query: 228  RL--GESCINTVGSFRC 242
             L     C+NT GSFRC
Sbjct: 1586 PLCVNARCLNTDGSFRC 1602



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 11/97 (11%)

Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KC 415
           V +C   +E  G   R V++P      C TG  F+ ++  C DV+EC    G  C H +C
Sbjct: 321 VHDCQLCSERLGNSER-VSAPDG---PCPTG--FERVNGSCEDVDECAT--GGRCQHGEC 372

Query: 416 ENTLGSYLCSCSVGFRLSVDGRSC--EDINECSSSPC 450
            NT G Y C C  GF L     SC  + +   +  PC
Sbjct: 373 ANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 409



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 8/92 (8%)

Query: 420  GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC 479
            GSY  S +  +   ++   C  ++ C++      C  V   + C C  GY+L D+  + C
Sbjct: 1519 GSYAGSLAEPYE-ELEAEECGILDGCTNG----RCVRVPEGFTCRCFDGYRL-DMTRMAC 1572

Query: 480  EDIDEC-ALPTGGHIC-SYRCINIPGSFQCSC 509
             DI+EC        +C + RC+N  GSF+C C
Sbjct: 1573 VDINECDEAEAASPLCVNARCLNTDGSFRCIC 1604



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 30/101 (29%), Positives = 45/101 (44%), Gaps = 13/101 (12%)

Query: 269 GIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
           G+H+C    +C   LG+      P   C +GF +   G+C D++EC +    C  G  C 
Sbjct: 320 GVHDCQ---LCSERLGNSERVSAPDGPCPTGF-ERVNGSCEDVDECAT-GGRCQHGE-CA 373

Query: 327 NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
           NT G YTC      C  G+ L+   + C+     +    PC
Sbjct: 374 NTRGGYTCV-----CPDGFLLDSSRSSCISQHVISEAKGPC 409



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 13/100 (13%)

Query: 223 GSHSCRLGESCINTVGSFR--CQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
           G H C+L   C   +G+       D  C TG+E   + SC+D+DEC +G         C 
Sbjct: 320 GVHDCQL---CSERLGNSERVSAPDGPCPTGFERV-NGSCEDVDECATG--GRCQHGECA 373

Query: 281 NTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPC 319
           NT G + C     C  GF+ D +  +CI  +       PC
Sbjct: 374 NTRGGYTC----VCPDGFLLDSSRSSCISQHVISEAKGPC 409



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 261  KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPC 319
            +D+DEC+          +C NT   + C     C +G+        CID +EC      C
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSC----YCSNGYYYHTQRLECIDNDECADEEPAC 1307

Query: 320  PIGHTCINTEGSYTCQKNVP 339
              G  C+NT GSY C    P
Sbjct: 1308 E-GGRCVNTVGSYHCTCEPP 1326



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)

Query: 400 VNECQRYPGRLCGHKCENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECA 455
           V++CQ     LC  +  N+  + +    C  GF   V+G SCED++EC++    Q  ECA
Sbjct: 321 VHDCQ-----LCSERLGNSERVSAPDGPCPTGFE-RVNG-SCEDVDECATGGRCQHGECA 373

Query: 456 NVYGSYQCYCRRGYQL 471
           N  G Y C C  G+ L
Sbjct: 374 NTRGGYTCVCPDGFLL 389



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 15/86 (17%)

Query: 252  YELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDIN 310
            YE  E   C  +D C +G         C      F CR    C  G+  D     C+DIN
Sbjct: 1529 YEELEAEECGILDGCTNGR--------CVRVPEGFTCR----CFDGYRLDMTRMACVDIN 1576

Query: 311  ECLSISAPCP--IGHTCINTEGSYTC 334
            EC    A  P  +   C+NT+GS+ C
Sbjct: 1577 ECDEAEAASPLCVNARCLNTDGSFRC 1602



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 16/131 (12%)

Query: 112  CCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQ 171
            CC +G   +  G  C      G +  + +++ C   +  G L   G    D  +  + ++
Sbjct: 1207 CCTVG---EGWGSGCRIQQCPGTETAE-YQSLCPHGR--GYLAPSG----DLSLRRDVDE 1256

Query: 172  EDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGE 231
               + +  C+ G      C +T     C C  GY   +  + C D +EC     +C  G 
Sbjct: 1257 CQLFRDQVCKSG-----VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACE-GG 1310

Query: 232  SCINTVGSFRC 242
             C+NTVGS+ C
Sbjct: 1311 RCVNTVGSYHC 1321



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 17/123 (13%)

Query: 447 SSPCSQECANVYGSYQCY--CRRGYQLSDVDGVTCEDI--DECALPTGGHICSYRCINIP 502
           S+P     ++  G   C+   R G   S + G+  +++      L  G H C      + 
Sbjct: 273 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 332

Query: 503 GSFQCS-----CPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
            S + S     CP+   R+  NG +C+D+DEC TG   C   E C N +GG+ C+   CP
Sbjct: 333 NSERVSAPDGPCPTGFERV--NG-SCEDVDECATG-GRCQHGE-CANTRGGYTCV---CP 384

Query: 558 ENY 560
           + +
Sbjct: 385 DGF 387



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 8/59 (13%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS 259
           C  G++ ++   SCEDV+EC TG   C+ GE C NT G + C     C  G+ L    S
Sbjct: 344 CPTGFERVNG--SCEDVDECATGGR-CQHGE-CANTRGGYTC----VCPDGFLLDSSRS 394


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  235 bits (600), Expect = 9e-62
 Identities = 139/401 (34%), Positives = 204/401 (50%), Gaps = 45/401 (11%)

Query: 190  CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
            C +T     C CF GY+       +C D++EC      CR G +C+NT GSF+C     C
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185

Query: 249  GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305
              G+EL+     C DI+EC    + C  +  C N +G+++C     C  G+    D  G 
Sbjct: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239

Query: 306  CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
            C DI+EC+ ++  C     C N+EGSY C     +C  GY L  +G  C D+DEC    +
Sbjct: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292

Query: 366  PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425
             C  G +C N PG +RC C  G+      + C+DVNEC          +CENT GS++C 
Sbjct: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351

Query: 426  CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
            C +G+ +      C D++EC     +      C N+ GS++C CR G+     +G+ C D
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408

Query: 482  IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
            +DEC+   G H CS   +C+N PGS++C+C S G+    +G  C D+DEC   I+ C  N
Sbjct: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462

Query: 540  ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
              C N+ G +RC   EC   +  ++ +R     C +  ECS
Sbjct: 1463 GQCLNVPGAYRC---ECEMGFTPASDSR----SCQDIDECS 1496



 Score =  229 bits (584), Expect = 6e-60
 Identities = 156/480 (32%), Positives = 209/480 (43%), Gaps = 112/480 (23%)

Query: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C  G PC    C +      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271

Query: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294
             GS+ C    +C  GY L ED   CKD+DEC  G+H+C     +C+N +G+F C     C
Sbjct: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323

Query: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
              G  +   G  C+D NEC +    C  G  C+N  GSY C+     C  G+  +  GT 
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377

Query: 354  CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382
            C+D  +                        +E C     G GH+C     PG+ +    C
Sbjct: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437

Query: 383  ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
                GY  DG      D++EC+  P      +C NT+GS+ C C VG+   + G SC D+
Sbjct: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492

Query: 443  NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500
            +ECS S  PC+  C N  GSYQC C RGY L + DG TC+D+DEC   T  H C + C+N
Sbjct: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549

Query: 501  IPGSFQCSCP----------------------------------------SSGYRLAPNG 520
              G F C CP                                          G+ L   G
Sbjct: 2550 TLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATG 2609

Query: 521  RNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
             NC+D+DEC  G H C     C NI GG+RC    CP+ Y        +   C +  ECS
Sbjct: 2610 LNCEDVDEC-DGNHRC--QHGCQNILGGYRC---GCPQGY----IQHYQWNQCVDENECS 2659



 Score =  214 bits (545), Expect = 2e-55
 Identities = 140/399 (35%), Positives = 186/399 (46%), Gaps = 57/399 (14%)

Query: 199  CSCFVGYQLLSDGVSCEDVNECITGSHS----CRLGESCINTVGSFRCQRDSSCGTGYEL 254
            C C  G+Q  S G  C D  + +  +      C++  S  N V    C  D   G G++ 
Sbjct: 2363 CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422

Query: 255  ---------------------TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293
                                 T D   +DIDEC+  + N   +  C NT+GSFRC     
Sbjct: 2423 ELCPLPGTAQYKKICPHGPGYTTDG--RDIDECKV-MPNLCTNGQCINTMGSFRCF---- 2475

Query: 294  CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352
            CK G+  D  G +CID++EC     PC   + C NTEGSY C     +C RGY L E+G 
Sbjct: 2476 CKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC-----SCPRGYVLQEDGK 2528

Query: 353  RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412
             C D+DEC      C     CVN+ G F C+C  G  F      C+D NEC   P  LCG
Sbjct: 2529 TCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG--FTQHHTACIDNNECGSQPS-LCG 2583

Query: 413  HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECANVYGSYQCYCRRGY 469
             K  C+NT GS+ C C  GF L   G +CED++EC  +  C   C N+ G Y+C C +GY
Sbjct: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643

Query: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
             +       C D +EC+ P      S  C N  GS++C+CPS G+        C D++EC
Sbjct: 2644 -IQHYQWNQCVDENECSNPNACGSAS--CYNTLGSYKCACPS-GFSFDQFSSACHDVNEC 2699

Query: 530  VTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRC 568
             +  + C  N  C N +GG+ C    CP  Y R     C
Sbjct: 2700 SSSKNPC--NYGCSNTEGGYLC---GCPPGYYRVGQGHC 2733



 Score =  207 bits (528), Expect = 2e-53
 Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)

Query: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68
            PLL  GG       V+ +   +  C  GH ++  ++DC      +  EC +    C    
Sbjct: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215

Query: 69   CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119
            C + +    C+         DR        C   +G     + T  +    C C  G A 
Sbjct: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274

Query: 120  QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168
               G+SC           +  G QC  +   +R  C           G +   D    ++
Sbjct: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325

Query: 169  EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227
              + D  LN   C  G     +C +T    +C C +GY +      C DV+EC  G+H+C
Sbjct: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378

Query: 228  RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287
             +  SC+N  GSF+C    SC  G+ +     C D+DEC +G H C  +  C NT GS+R
Sbjct: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433

Query: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347
            C     C  GF  D    C D++EC      C  G  C+N  G+Y C+     C  G+  
Sbjct: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482

Query: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407
              +   C D+DEC+     C  G  C N PG F C C  GY  D     C D++EC   P
Sbjct: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539

Query: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456
                   C NT G Y C+C   F+L+  G  C D  +  C          S  C+ E   
Sbjct: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599

Query: 457  VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486
                  C C  G                  Y L         +   +  EDIDEC     
Sbjct: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659

Query: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546
            L  GG+     CIN  GSFQC CP  GY L+ + R C+DIDEC      C    TC+N  
Sbjct: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712

Query: 547  GGFRCLAFECPENY 560
            G + C+   CP  Y
Sbjct: 1713 GNYTCI---CPPEY 1723



 Score =  204 bits (518), Expect = 3e-52
 Identities = 120/284 (42%), Positives = 143/284 (50%), Gaps = 25/284 (8%)

Query: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
            QC +T     C C VGY     G SC D++EC      C     C NT GS++C    SC
Sbjct: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY--ICKNTEGSYQC----SC 2517

Query: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI 307
              GY L ED  +CKD+DEC++  HNC   F+C NTLG F C+    C  GF Q     CI
Sbjct: 2518 PRGYVLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTCK----CPPGFTQHHTA-CI 2570

Query: 308  DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367
            D NEC S  + C     C NT GS++C+     C RG+ L+  G  C DVDEC      C
Sbjct: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCE-----CQRGFSLDATGLNCEDVDEC-DGNHRC 2624

Query: 368  GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCS 427
               H C N  G +RC C  GY        CVD NEC   P       C NTLGSY C+C 
Sbjct: 2625 Q--HGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACP 2681

Query: 428  VGFRLSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGY 469
             GF       +C D+NECSSS  PC+  C+N  G Y C C  GY
Sbjct: 2682 SGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725



 Score =  202 bits (513), Expect = 1e-51
 Identities = 152/472 (32%), Positives = 206/472 (43%), Gaps = 108/472 (22%)

Query: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237
            +C ++     C C  G  L   G  C D+           +ECI         ++C   V
Sbjct: 970  RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029

Query: 238  GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278
            G+     C+     GT                G  LT     KDI+EC++    C     
Sbjct: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088

Query: 279  CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337
            C+NT+GSF+CR    C SGF  D    NC DI+EC      C  G  C+NT GS+ C+  
Sbjct: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141

Query: 338  VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393
               C  GY   E G      C+D+DEC      C +G  CVN+ GSF+C+C  G+     
Sbjct: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194

Query: 394  SRMCVDVNEC---------------------------QRYPGRL--------------CG 412
               CVD+NEC                           Q  P R               C 
Sbjct: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254

Query: 413  HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGY 469
             +C N+ GSY CSCS G+ L  DGRSC DI+EC ++P  C   +C N+ G Y+C C  G+
Sbjct: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGF 1314

Query: 470  QLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE 528
             ++ +D  TC D++EC L    +IC +  C N  GSF C C   GY +      C D+DE
Sbjct: 1315 -MASMDMKTCIDVNECDL--NSNICMFGECENTKGSFICHC-QLGYSVKKGTTGCTDVDE 1370

Query: 529  CVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
            C  G HNC ++ +C NI G F+C    C E +  +       + C +  ECS
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKC---SCREGWIGNG------IKCIDLDECS 1413



 Score =  200 bits (508), Expect = 4e-51
 Identities = 141/466 (30%), Positives = 195/466 (41%), Gaps = 100/466 (21%)

Query: 186  CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL-GESCINTVGSFRC-- 242
            C  +C +T     C+C +GY L  D   C+D++EC  G H C   G  C N +G+F C  
Sbjct: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323

Query: 243  -------------QRDSSCGTGYELTEDNSCKDID-----ECESGIHN------CLPD-- 276
                           ++ C T   + E+  C +I      EC  G  +      CL +  
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383

Query: 277  ---------FICQNTLGSFRCRPKLQC-----------------------------KSGF 298
                      ICQ    S     K +C                               G+
Sbjct: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443

Query: 299  IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVD 358
              D      DI+EC  +   C  G  CINT GS+ C      C  GY  +  GT C+D+D
Sbjct: 2444 TTDGR----DIDECKVMPNLCTNGQ-CINTMGSFRCF-----CKVGYTTDISGTSCIDLD 2493

Query: 359  ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT 418
            EC+   +PC   + C N+ GS++C C  GY      + C D++ECQ      C   C NT
Sbjct: 2494 ECSQSPKPCN--YICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNT 2550

Query: 419  LGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDV 474
            LG + C C  GF  +    +C D NEC S P  C  +  C N  GS+ C C+RG+ L D 
Sbjct: 2551 LGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL-DA 2607

Query: 475  DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534
             G+ CED+DEC    G H C + C NI G ++C CP  GY        C D +EC     
Sbjct: 2608 TGLNCEDVDEC---DGNHRCQHGCQNILGGYRCGCP-QGYIQHYQWNQCVDENECSN--P 2661

Query: 535  NCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
            N   + +C+N  G ++C    CP  +     +      CH+  ECS
Sbjct: 2662 NACGSASCYNTLGSYKC---ACPSGFSFDQFSSA----CHDVNECS 2700



 Score =  196 bits (497), Expect = 8e-50
 Identities = 123/364 (33%), Positives = 169/364 (46%), Gaps = 48/364 (13%)

Query: 180  CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233
            C GG     QC           + +C    GY   +DG    D++EC    + C  G+ C
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465

Query: 234  INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
            INT+GSFRC     C  GY       SC D+DEC      C  ++IC+NT GS++C    
Sbjct: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515

Query: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351
             C  G++    G  C D++EC +    C     C+NT G +TC+     C  G+   +  
Sbjct: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566

Query: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411
            T C+D +EC      CG    C N+PGSF CEC+ G+  D     C DV+EC       C
Sbjct: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG--NHRC 2624

Query: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469
             H C+N LG Y C C  G+        C D NECS+ + C S  C N  GSY+C C  G+
Sbjct: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684

Query: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
                     C D++EC+  +  + C+Y C N  G + C CP   YR+            C
Sbjct: 2685 SFDQFSSA-CHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733

Query: 530  VTGI 533
            V+G+
Sbjct: 2734 VSGM 2737



 Score =  195 bits (496), Expect = 1e-49
 Identities = 149/501 (29%), Positives = 206/501 (41%), Gaps = 118/501 (23%)

Query: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220
            T K ++++E +E P +   C  G      C +      C C  G+      + CED++EC
Sbjct: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854

Query: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280
              G + C+    CIN+ GS+RC+    C  G++L+ + +C D +EC   I N     +C 
Sbjct: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909

Query: 281  NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
            +  GS++C     C +GF   QD    C+D++EC     PC  G TC NT GSY C    
Sbjct: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958

Query: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
              C  G+ L      C+D+DEC+       +  RC N  GSF+C C  GY      + C+
Sbjct: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015

Query: 399  DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455
            D NEC   PG      C+N  GS+ C C  G+   V   +C DINEC   P       C 
Sbjct: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073

Query: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGH------------ 492
            N  G +QC C  G+ LSD +G  C D             +C++P   +            
Sbjct: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132

Query: 493  ---------------------ICSY----------------RCINIPG------------ 503
                                 +C Y                 C+  PG            
Sbjct: 2133 GEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDG 2192

Query: 504  SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563
            SF+C CP  GY L   G  C D DEC  G  N   N TC N+ G F C    C E +   
Sbjct: 2193 SFRCECP-MGYNLDYTGVRCVDTDECSIG--NPCGNGTCTNVIGSFEC---NCNEGFEPG 2246

Query: 564  AATRCERLPCHENRECSKLPL 584
                CE +      EC++ PL
Sbjct: 2247 PMMNCEDI-----NECAQNPL 2262



 Score =  189 bits (480), Expect = 7e-48
 Identities = 136/404 (33%), Positives = 181/404 (44%), Gaps = 71/404 (17%)

Query: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274
           + ++ C   ++ C  G  CI TV S+RC+    C  GY+   +  C D+DEC S   N  
Sbjct: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544

Query: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333
            +  C NT GS+ C+    C +GF +      CIDI+EC+     C  G  C+NT+GS+ 
Sbjct: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599

Query: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393
           C      C  G+ L  +G  CVD DEC      C  G  C+N  GSF+C CK G+     
Sbjct: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652

Query: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442
            R C DV+ECQ  PG      C N+ GS+ C C  G  + +DGR C D            
Sbjct: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711

Query: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
                         +EC           PC    A     +   C  G  ++ VDG    
Sbjct: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767

Query: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
           DI+ECAL     IC+   C N+ GS++C+C +SGY    +GRNC DIDEC+     C  N
Sbjct: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823

Query: 540 ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
             C N  G + C    CP  Y      R E   C +  EC   P
Sbjct: 824 GLCRNTPGSYSC---TCPPGY----VFRTETETCEDINECESNP 860



 Score =  174 bits (440), Expect = 3e-43
 Identities = 141/454 (31%), Positives = 187/454 (41%), Gaps = 75/454 (16%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           D C         C +T     C C  G+Q      +C D++ECI     C+ G  C+NT 
Sbjct: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595

Query: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           GSF+C     C  G+ELT D  +C D DEC +  + CL + +C N  GSF+C     CK 
Sbjct: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645

Query: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
           GF+    G  C D++EC +    C  GH CIN+EGS+ C     +C  G  +  +G  CV
Sbjct: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698

Query: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386
           D                           EC       G G  C   P     E    C +
Sbjct: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758

Query: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446
           G    GI+    D+NEC   P       CEN  GSY C+C+ G+     GR+C DI+EC 
Sbjct: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815

Query: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503
            +    +   C N  GSY C C  GY +   +  TCEDI+EC         +  C N  G
Sbjct: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871

Query: 504 SFQCSCPSSGYRLAPNGRNCQDI-----------DECVTGIHNCSINETCFNIQG---GF 549
           SF C C S G +L+  G  C D              C   I+  ++   C    G   G 
Sbjct: 872 SFNCEC-SPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGS 930

Query: 550 RCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
            C   E      R  A R + + C +  EC   P
Sbjct: 931 PCERCELDTACPRGLA-RIKGVTCEDVNECEVFP 963



 Score =  168 bits (425), Expect = 2e-41
 Identities = 139/464 (29%), Positives = 194/464 (41%), Gaps = 96/464 (20%)

Query: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
            QC +      C C +G+   SD  SC+D++EC +  + C  G +C N  G F C     C
Sbjct: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517

Query: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302
              GYEL     +C DIDEC   I NC+ + +C NT G + C   P  Q      G + + 
Sbjct: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575

Query: 303  LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337
            +GNC           +  N  + +     S  C +G        TC  +N+   YT    
Sbjct: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635

Query: 338  VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397
                G G+  N       D+DEC      C +G  C+N+ GSF+CEC  GYY    +R+C
Sbjct: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690

Query: 398  VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450
             D++EC  +PG +CG   C NTLG+Y C C   +     G +C D+ +       + + C
Sbjct: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749

Query: 451  SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480
              E         C C   Y +       CE                              
Sbjct: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807

Query: 481  DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539
            DIDEC    G  IC+   CIN  GSF+C CP +G+        C+DIDEC  G + C  N
Sbjct: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864

Query: 540  ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
              C N  G +RC   EC   ++ S    C      +  EC ++P
Sbjct: 1865 ADCINSPGSYRC---ECAAGFKLSPNGACV-----DRNECLEIP 1900



 Score =  149 bits (376), Expect = 8e-36
 Identities = 175/634 (27%), Positives = 242/634 (38%), Gaps = 134/634 (21%)

Query: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81
            V+ D   +  C  G  + T  K+C      +  EC    M     C ++     C    G
Sbjct: 592  VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646

Query: 82   ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131
              LA       + D C TP    +G   + E +F  RC   C  G A    G+ C  + M
Sbjct: 647  FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702

Query: 132  VGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCR 191
                 G + +  CV+         G + +++              N     G PC+    
Sbjct: 703  RSTCYGGIKKGVCVRPFP------GAVTKSECCCA----------NPDYGFGEPCQPCPA 746

Query: 192  DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTG 251
                E    C  G  +  DG    D+NEC      C  G  C N  GS+RC    +C +G
Sbjct: 747  KNSAEFHGLCSSGVGITVDG---RDINECALDPDICANG-ICENLRGSYRC----NCNSG 798

Query: 252  YEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI-QDALGNCIDI 309
            YE      +C DIDEC      C  + +C+NT GS+ C     C  G++ +     C DI
Sbjct: 799  YEPDASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCT----CPPGYVFRTETETCEDI 853

Query: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD------------- 356
            NEC S   PC  G  C N  GS+ C+     C  G  L+  G  C+D             
Sbjct: 854  NECES--NPCVNG-ACRNNLGSFNCE-----CSPGSKLSSTGLICIDSLKGTCWLNIQDS 905

Query: 357  -----VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM----CVDVNECQRYP 407
                 ++     +E C        SP   RCE  T     G++R+    C DVNEC+ +P
Sbjct: 906  RCEVNINGATLKSECCATLGAAWGSPCE-RCELDTACP-RGLARIKGVTCEDVNECEVFP 963

Query: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI--NECSSSPCSQECAN--------- 456
            G     +C N+ GS+ C C  G  L   GR C DI   +C       EC +         
Sbjct: 964  GVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMD 1023

Query: 457  --------VYGS------------YQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491
                     +G+            Y+  C RG   ++   V       +DI+EC    G 
Sbjct: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082

Query: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550
             +C+Y +C N  GSF+C C +SG+ L    RNC DIDEC      C  +  C N  G F 
Sbjct: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139

Query: 551  CLAFECPENYRRSAATRCERLPCHENRECSKLPL 584
            C   EC E Y            C +  EC + PL
Sbjct: 1140 C---ECFEGYESGFMMMKN---CMDIDECERNPL 1167



 Score =  144 bits (363), Expect = 3e-34
 Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)

Query: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271
           +C+DV+EC      C+ G +CINTVGSF C+    C  G++ +E    C+DIDEC S I 
Sbjct: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326

Query: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305
                  C NT+GS+               RC  +    C SG +     Q+  G     
Sbjct: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386

Query: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340
             C +   C  I      CP+  +    E    C   +P                     
Sbjct: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443

Query: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396
             G G      GT  + +        P G G     SPG        G       G++ +
Sbjct: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491

Query: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455
              ++ C+ +       +C  T+ SY C C++G++   +G  C D++EC+S+PC+  +C 
Sbjct: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550

Query: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514
           N  GSY C C  G+Q +      C DIDEC     G +C + RC+N  GSFQC C ++G+
Sbjct: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606

Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
            L  +G+NC D DEC T   N  +N  C N  G F+C+
Sbjct: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259
           C  G++ L  G      N+CI           C N+ G   C R + C  +  +++    
Sbjct: 97  CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142

Query: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312
            K I +C     N   C  D   CQ   +G++  +P  +  C++G      G CI  N C
Sbjct: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196

Query: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369
                 C  G T    E  Y    C   V N      L   G  C     CA      G 
Sbjct: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248

Query: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429
            H C   P   +  C+ G+  +  +  C DV+ECQ  PG   G  C NT+GS+ C C  G
Sbjct: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306

Query: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
            + S   + CEDI+ECS  P  C   EC+N  GSY C C RGY ++  DG  C  ID+  
Sbjct: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363

Query: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509
                 + + RC   +PG     QC C
Sbjct: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)

Query: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
           RC  GG C     QC+       C    G  +  +G  C++   CI G + C    +C+ 
Sbjct: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200

Query: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
                +C+RD   G                C + ++N +    CQ  L    C   L C 
Sbjct: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241

Query: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
           +  I  A G+            PC +            C      C RG+  N     C 
Sbjct: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275

Query: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
           DVDEC      C +G  C+N+ GSF C C  G+     ++ C D++EC   PG     +C
Sbjct: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334

Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468
            NT+GSY C C  G+  S DG  C D       +   +  C+QE        QC C  G
Sbjct: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 98/306 (32%), Positives = 129/306 (42%), Gaps = 76/306 (24%)

Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
           IC+N+ G   C RP +  C SG I    G+   I +C   S  C  G TC +      CQ
Sbjct: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165

Query: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388
                C +GY     GT C       P  E  C  G RC+   G  RC C  G+      
Sbjct: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208

Query: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446
             Y  G     V+   CQ   G+L G  C  TL    C  ++G      G  CE    C 
Sbjct: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255

Query: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505
           + P               CRRG+ + ++    C+D+DEC    G  IC    CIN  GSF
Sbjct: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299

Query: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563
           +C CP +G++ +   + C+DIDEC  + GI  C   E C N  G + C+   CP  Y  S
Sbjct: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGYVTS 352

Query: 564 A-ATRC 568
              +RC
Sbjct: 353 TDGSRC 358



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)

Query: 36   CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73
            CC DG R   HQ + C LP              Y T+ +   EC+++   C    C + +
Sbjct: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469

Query: 74   EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124
                C       T IS  +  + D C+ +P   N   + T     C C   G   Q  G+
Sbjct: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528

Query: 125  SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158
            +C+                 + + G+ C            C+ + E G         G  
Sbjct: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588

Query: 159  QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210
            Q T      E ++    +   LN    D C G   C+  C++      C C  GY     
Sbjct: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648

Query: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269
               C D NEC +  ++C    SC NT+GS++C    +C +G+   +  ++C D++EC S 
Sbjct: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702

Query: 270  IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325
             + C  ++ C NT G + C     C  G+ +   G+C+     N+   +S    +     
Sbjct: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756

Query: 326  INTEGSYTCQKN 337
            ++ E  Y C+ N
Sbjct: 2757 LSPEACYECKIN 2768


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  234 bits (596), Expect = 3e-61
 Identities = 177/557 (31%), Positives = 246/557 (44%), Gaps = 80/557 (14%)

Query: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQC----CHSQLEELHCAT--GISLANEQDR 90
            C  G   A+       P+  +  EC++    C    C + +   HCA   G +L  ++  
Sbjct: 966  CPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERN 1025

Query: 91   CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150
            C        S +          C  G      G S E     GY+ G +    C+   E 
Sbjct: 1026 CTDIDECRISPDL---------CGQGTCVNTPG-SFECECFPGYESGFMLMKNCMDVDEC 1075

Query: 151  GDLDV----GGLQETDKIIEVE--------------EEQEDPYLNDRCRGGGPCKQ-QCR 191
                +    G    TD   + +              E+ ++  L+D     G C   QC 
Sbjct: 1076 ARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSD-----GLCPHGQCV 1130

Query: 192  DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTG 251
            +      CSC  G+Q   D   C D+NEC   +  C +   CINT GS+RC    SCG G
Sbjct: 1131 NVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDV--HCINTEGSYRC----SCGQG 1184

Query: 252  YELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-LGNCIDI 309
            Y L  D  +C D+DECE     C     C N  G  RC     C  GF+    +  C+D+
Sbjct: 1185 YSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCL----CYDGFMATPDMRTCVDV 1239

Query: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369
            +EC      C  G  C NT+GS+ C     +C  GY + +  T C DVDEC      C  
Sbjct: 1240 DECDLNPHICLHGD-CENTKGSFVC-----HCQLGYMVRKGATGCSDVDECEVGGHNCDS 1293

Query: 370  GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK--CENTLGSYLCSCS 427
               C+N PGSF C C  G+  DG    C D++EC     R C  +  C N  GSY C+C 
Sbjct: 1294 HASCLNIPGSFSCRCLPGWVGDGFE--CHDLDECVSQEHR-CSPRGDCLNVPGSYRCTCR 1350

Query: 428  VGFRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDE 484
             GF  + DG  CED +EC+ +   C   +C N  G Y+C C  G+  ++ D   C+D+DE
Sbjct: 1351 QGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTE-DHRACQDVDE 1407

Query: 485  CALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF 543
            CA    G++C++  C N+PG F+C C + GY L   G NC DI+EC   + NC IN  C 
Sbjct: 1408 CA---QGNLCAFGSCENLPGMFRCIC-NGGYELDRGGGNCTDINECADPV-NC-INGVCI 1461

Query: 544  NIQGGFRCLAFECPENY 560
            N  G + C    CP+++
Sbjct: 1462 NTPGSYLC---SCPQDF 1475



 Score =  219 bits (557), Expect = 9e-57
 Identities = 167/517 (32%), Positives = 225/517 (43%), Gaps = 97/517 (18%)

Query: 113  CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162
            C  G +    G +C  +    VG+ CGQ         F   C    E G      L  T 
Sbjct: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164

Query: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222
            +  +++E   +P L         C  +C +T    +C+C  GY L  DG  C DV+EC  
Sbjct: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213

Query: 223  GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276
            G   C   G  C N +G+F C          G+G   T+DN C    D C +G       
Sbjct: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266

Query: 277  FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316
              C NT GSFRC     C  GF     L  C DI +           C S+S        
Sbjct: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321

Query: 317  APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
            A C  G               G+   +K  P+ G GY    EG    DVDEC   A  C 
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375

Query: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428
             G  C+NS GSFRC C+ GY  D  +  C+D++EC + P + C   C+NT GS+LCSC  
Sbjct: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433

Query: 429  GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486
            G+ L  DGR+C+D++EC+S    C   C N  G++ C C  G+         C D DEC+
Sbjct: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490

Query: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546
               G       C N PGSF+C C   G+ L  +G  C+D++EC  G H C     C N  
Sbjct: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546

Query: 547  GGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
            GG+RC    CP+ + + +    +   C +  EC+  P
Sbjct: 2547 GGYRC---SCPQGFTQHS----QWAQCVDENECALSP 2576



 Score =  215 bits (547), Expect = 1e-55
 Identities = 159/465 (34%), Positives = 211/465 (45%), Gaps = 59/465 (12%)

Query: 181  RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
            RG GP  + C   G       C  G    ++G    DV+EC   +H C  GE CIN++GS
Sbjct: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385

Query: 240  FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            FRC     C  GY  T D    +C D+DEC      C   F+C+NT GSF C     C  
Sbjct: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433

Query: 297  GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            G++ +  G  C D++EC S    C     C+NT G++TC+     C  G+  + +   C 
Sbjct: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484

Query: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
            D DEC+    PCG    C N+PGSFRCEC  G+        C DVNEC   P R C H C
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542

Query: 416  ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472
            +N LG Y CSC  GF        C D NEC+ SP  C S  C N  G ++C C  G+   
Sbjct: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602

Query: 473  DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532
               G  C+++DECA   G   CSY C N PG F C CP  GY  A  G        CV+G
Sbjct: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCP-QGYFRAGQG-------HCVSG 2651

Query: 533  I------HNCSINETCFNIQGGFRC-LAFECPENYRRSAATRCERLPCHENRECSKLPLR 585
            +       +    E   + +  + C +    P +  R +A R  ++        + L L 
Sbjct: 2652 LGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLG 2711

Query: 586  ITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFF 630
            +   HL     I        + P+       ++  I  GNE+GFF
Sbjct: 2712 LNLSHLGRAERI------LELRPALEGLEGRIRYVIVRGNEQGFF 2750



 Score =  214 bits (546), Expect = 2e-55
 Identities = 136/379 (35%), Positives = 186/379 (49%), Gaps = 34/379 (8%)

Query: 179  RCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVG 238
            R + GG C   C +T     CSC  GY L+ DG +C DV+EC      C  G  C N  G
Sbjct: 1160 RVQNGG-CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG 1217

Query: 239  SFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
              RC     C  G+  T D  +C D+DEC+   H CL    C+NT GSF C     C+ G
Sbjct: 1218 GHRC----LCYDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVC----HCQLG 1268

Query: 298  F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356
            + ++     C D++EC      C    +C+N  GS++C+     C  G+    +G  C D
Sbjct: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGW--VGDGFECHD 1321

Query: 357  VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE 416
            +DEC      C     C+N PGS+RC C+ G+  DG    C D +EC          +C 
Sbjct: 1322 LDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDECAENVDLCDNGQCL 1379

Query: 417  NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCS-QECANVYGSYQCYCRRGYQLSDV 474
            N  G Y C C +GF  + D R+C+D++EC+  + C+   C N+ G ++C C  GY+L D 
Sbjct: 1380 NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL-DR 1438

Query: 475  DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534
             G  C DI+ECA P   +  +  CIN PGS+ CSCP   + L P+G  C D     T   
Sbjct: 1439 GGGNCTDINECADPV--NCINGVCINTPGSYLCSCPQD-FELNPSGVGCVD-----TRAG 1490

Query: 535  NCSINETCFNIQGGFRCLA 553
            NC + ET      G  C A
Sbjct: 1491 NCFL-ETHDRGDSGISCSA 1508



 Score =  202 bits (515), Expect = 6e-52
 Identities = 160/531 (30%), Positives = 226/531 (42%), Gaps = 93/531 (17%)

Query: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146
            E  +C+ P   N +           CC   R  +  G  CE     G      F+  C  
Sbjct: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068

Query: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206
                G   V G  ++ +  +V E  E+P +   C  G      C +T     C C  GY 
Sbjct: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116

Query: 207  LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266
            L   G++C D +EC  G H C  G +C N +G F C    +C  G+E     +C+DIDEC
Sbjct: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170

Query: 267  ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPI-GHT 324
               ++  L  F C NT GS+ C     C +G+ +++    C D++EC      C   G  
Sbjct: 2171 --SLNPLLCAFRCHNTEGSYLC----TCPAGYTLREDGAMCRDVDECADGQQDCHARGME 2224

Query: 325  CINTEGSYTCQKNVPNCGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
            C N  G++ C      C  G   L   G  C D +EC    + C  G RCVN+ GSFRC+
Sbjct: 2225 CKNLIGTFACV-----CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCD 2278

Query: 384  CKTGY-----------------YFDGISRMCVDVN---------ECQRYPGRLCGHKCE- 416
            C  G+                 + + +  MC  ++         EC    GR  G +CE 
Sbjct: 2279 CDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338

Query: 417  ---NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSD 473
                   +Y   C  G   + +GR  ++    +      EC N  GS++C+C+ GY   D
Sbjct: 2339 CPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGY-TPD 2397

Query: 474  VDGVTCEDIDECA-LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532
                TC D+DEC+ +P     C++ C N  GSF CSCP  GY L  +GR C+D+DEC + 
Sbjct: 2398 ATATTCLDMDECSQVPKP---CTFLCKNTKGSFLCSCP-RGYLLEEDGRTCKDLDECTSR 2453

Query: 533  IHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
             HNC     C N  G F C    CP  + +          C +N ECS  P
Sbjct: 2454 QHNCQF--LCVNTVGAFTC---RCPPGFTQ------HHQACFDNDECSAQP 2493



 Score =  200 bits (509), Expect = 3e-51
 Identities = 146/438 (33%), Positives = 198/438 (45%), Gaps = 63/438 (14%)

Query: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234
            +C +T     C C  G  L + G  C DV           +EC +T     R+   C  I
Sbjct: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943

Query: 235  NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279
              V    C+           S C  G G+   +  S     KD++EC+     C     C
Sbjct: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002

Query: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338
            +NT+GSF C     C  GF  DA   NC DI+EC      C  G TC+NT GS+ C+   
Sbjct: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056

Query: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
            P    G+ L +    C+DVDECA     C +G  C N+ GS++C+C  G+        C 
Sbjct: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112

Query: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455
            D++EC    G LC H +C N +G++ CSC  GF+ + D + C DINEC   +  C   C 
Sbjct: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171

Query: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514
            N  GSY+C C +GY L   DG  C D+DEC       +C    C N+PG  +C C   G+
Sbjct: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227

Query: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR-RSAATRCERLP- 572
               P+ R C D+DEC    H C ++  C N +G F C    C   Y  R  AT C  +  
Sbjct: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC---HCQLGYMVRKGATGCSDVDE 1283

Query: 573  -------CHENRECSKLP 583
                   C  +  C  +P
Sbjct: 1284 CEVGGHNCDSHASCLNIP 1301



 Score =  188 bits (478), Expect = 1e-47
 Identities = 162/511 (31%), Positives = 218/511 (42%), Gaps = 88/511 (17%)

Query: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163
            K CC    +G+A     ++C   +   YQ  CG         +Q  G L D+     T K
Sbjct: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718

Query: 164  IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223
             ++++E  E P +   C  G      C +      C C  G+   S  ++CEDV+EC + 
Sbjct: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770

Query: 224  SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
               C+    CIN  GS+RC+    C  GY+L+   +C   +EC   I N      C +T 
Sbjct: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825

Query: 284  GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342
            GS+ C     C  GF   A    C+DI+EC     PC  G TC N  GSY C      C 
Sbjct: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873

Query: 343  RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
             G+ +   G  CVD DEC     + C  GH C+N+ GSF C C+ G+      + CVD N
Sbjct: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931

Query: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458
            EC    G      C+N  GS+ C C  GF++  D   C DI+ECS  P       C N  
Sbjct: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989

Query: 459  GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503
            GS+QC C  G+ LSD +G  C D             +C++P   +    RC     PG  
Sbjct: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048

Query: 504  -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549
                C  CP  G      L P G           +D++EC      C+ N  C N  G F
Sbjct: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107

Query: 550  RCLAFECPENYRRSAATRCERLPCHENRECS 580
            RC   ECP  Y    +     + C +  ECS
Sbjct: 2108 RC---ECPFGY----SLDFTGINCVDTDECS 2131



 Score =  176 bits (447), Expect = 5e-44
 Identities = 144/455 (31%), Positives = 187/455 (41%), Gaps = 77/455 (16%)

Query: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
           D C    PC    C +      C C+ G+Q      +C DV+ECI     C LG  C+NT
Sbjct: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508

Query: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
            GSF+C     C  G+EL+ D  +C D +EC +       + +C N  GSF C     CK
Sbjct: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558

Query: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
            GF+    G+ C+DI+EC      C  GH C NTEGS+ CQ     C  G  +  +G  C
Sbjct: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611

Query: 355 VDV------------DECAPP-------AEPC------GKGHRCVNSP----GSFRCECK 385
           VD               CA P       +E C      G G  C   P      F+  C 
Sbjct: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCS 671

Query: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
           +G    GI+    D+NEC   P       CEN  GSY C C++G+     G+ C D++EC
Sbjct: 672 SGL---GITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDEC 728

Query: 446 --SSSPCSQE-CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
             +S  C    C N  GSY C C  G+     D   C+D+DEC         S  C N+ 
Sbjct: 729 ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQ-DTEICKDVDEC---LSSPCVSGVCRNLA 784

Query: 503 GSFQCSCPSSGYRLAPNGRNCQDI-----------DECVTGIHNCSINETCFNIQG---G 548
           GS+ C C   G RL P+G  C D              C   +   S+   C    G   G
Sbjct: 785 GSYTCKC-GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWG 843

Query: 549 FRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
             C   E      R  A R   + C +  EC   P
Sbjct: 844 SPCERCEIDPACARGFA-RMTGVTCDDVNECESFP 877



 Score =  162 bits (411), Expect = 7e-40
 Identities = 142/471 (30%), Positives = 200/471 (42%), Gaps = 93/471 (19%)

Query: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
            D C  G     QC +      C C +G+    D  +C+DV+EC  G+  C  G SC N  
Sbjct: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423

Query: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            G FRC     C  GYEL     +C DI+EC   + NC+ + +C NT GS+ C      + 
Sbjct: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477

Query: 297  -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330
                 G +    GNC     D  +  +S SA   +G T   C  + G             
Sbjct: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537

Query: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
            + T  + +   G G+  N       D+DEC      C +G  CVN+ GSF+CEC  GY+ 
Sbjct: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596

Query: 391  DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444
               +R+C D++EC  + G +CG   C NTLG+Y C C   +     G +C D+ +     
Sbjct: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655

Query: 445  --------------------CS-------SSPCSQECANVYGSYQCYCRR---GYQLSDV 474
                                CS       + PC      +   YQ  C     G+ L+D+
Sbjct: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF-LTDI 1714

Query: 475  DGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532
                  DIDEC  +P    IC+   CIN  GSF+C CP +G+        C+D+DEC + 
Sbjct: 1715 HTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGSR 1770

Query: 533  IHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
               C  N  C NI G +RC   +C   Y+ S    C         EC ++P
Sbjct: 1771 ESPCQQNADCINIPGSYRC---KCTRGYKLSPGGACV-----GRNECREIP 1813



 Score =  162 bits (410), Expect = 1e-39
 Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)

Query: 94   PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150
            PHG   + E   V  C    H C  G    + G                FR  C ++  T
Sbjct: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395

Query: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210
             D       + D+  +V +               PC   C++T    +CSC  GY L  D
Sbjct: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440

Query: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270
            G +C+D++EC +  H+C+    C+NTVG+F C+    C  G+      +C D DEC +  
Sbjct: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493

Query: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329
              C     C NT GSFRC    +C  GF   + G+ C D+NEC     P    H C N  
Sbjct: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546

Query: 330  GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389
            G Y C     +C +G+  + +  +CVD +ECA     CG    C N+ G FRC C +G+ 
Sbjct: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600

Query: 390  FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446
            FD     C +V+EC    G  C + C NT G +LC C  G+  +  G     +       
Sbjct: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659

Query: 447  SSPCSQECANVYGSYQC 463
             +P  +E  +    Y+C
Sbjct: 2660 DTPDKEELLSSEACYEC 2676



 Score =  162 bits (409), Expect = 1e-39
 Identities = 179/661 (27%), Positives = 252/661 (38%), Gaps = 138/661 (20%)

Query: 3    RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59
            +A P+R+  + +   ++ GGL  L   V+ +   +  C  G  ++   K+C      +  
Sbjct: 479  QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533

Query: 60   ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104
            EC    M     C ++     C        A G     + D C TP    +G   + E +
Sbjct: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593

Query: 105  FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164
            F  RC   CL G A    G+ C  + +     G + +  C +                  
Sbjct: 594  F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633

Query: 165  IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224
                 + E    N     G PC+        E    C  G  + +DG    D+NEC    
Sbjct: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690

Query: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283
              C  G  C N  GS+RC     C  GYE       C D+DEC      C   + CQN+ 
Sbjct: 691  EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744

Query: 284  GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
            GS+ C     C  GF   QD    C D++ECLS  +PC  G  C N  GSYTC+     C
Sbjct: 745  GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791

Query: 342  GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383
            G G  L+  GT C+D  +           C    +       C  + G+       RCE 
Sbjct: 792  GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851

Query: 384  ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
               C  G+    G++  C DVNEC+ +PG     +C NT GS+ C C  G  L   GR C
Sbjct: 852  DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909

Query: 440  EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468
             D+           +EC            C      V+G             +   C RG
Sbjct: 910  VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969

Query: 469  YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523
               +  D ++     +D++EC +  G  +C++  C N  GSF C+C + G+ L    RNC
Sbjct: 970  LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026

Query: 524  QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583
             DIDEC      C    TC N  G F C   EC   Y            C +  EC++ P
Sbjct: 1027 TDIDECRISPDLCG-QGTCVNTPGSFEC---ECFPGYESGFMLMKN---CMDVDECARDP 1079

Query: 584  L 584
            L
Sbjct: 1080 L 1080



 Score =  151 bits (382), Expect = 2e-36
 Identities = 113/350 (32%), Positives = 151/350 (43%), Gaps = 61/350 (17%)

Query: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322
           ID C    + CL +  C  T  S+RC    +C  G+ QD  G CID++EC   S+PC  G
Sbjct: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461

Query: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382
             C+N  G+Y C+     C  G+        CVDVDEC      C  G RCVN+ GSF+C
Sbjct: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514

Query: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
            C  G+      + CVD NEC      +C    C N  GS+ C C  GF L+  G  C D
Sbjct: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572

Query: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487
           I+EC +     +  C N  GS++C C  G  +   DG  C D               CA 
Sbjct: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631

Query: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
           P  G +    C                       FQ  C SSG  +  +GR   DI+EC 
Sbjct: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687

Query: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
                C+ N  C N++G +RC+   C   Y   A+ +     C +  EC+
Sbjct: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGASGK----DCTDVDECA 729



 Score =  147 bits (370), Expect = 4e-35
 Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)

Query: 94  PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153
           P G    L      +   C  +GRA    G  CE      + C + F           ++
Sbjct: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240

Query: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213
             G  Q+ D      E Q  P L   C+GG      C +      C C VG++L     +
Sbjct: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286

Query: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265
           CED         S   G  C   +     +R   C  G         EL       +  +
Sbjct: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344

Query: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306
                        G+   L  F        LG  R  P      G      GN       
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404

Query: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362
               IDI  C   +  C  G  C+ T  SY C+ NV     GY  +  G  C+DVDEC  
Sbjct: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454

Query: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422
            + PC  G  CVN PG++ C C  G+      + CVDV+EC    G     +C NT GS+
Sbjct: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512

Query: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480
            C C+ GF LS DG++C D NEC++S    +  C N  GS+ C C+ G+ L+   G  C 
Sbjct: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571

Query: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
           DIDEC  P  G   +  C N  GSF+C C   G  +  +GR C D
Sbjct: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 111/458 (24%), Positives = 151/458 (32%), Gaps = 135/458 (29%)

Query: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335
           IC+   G   C +P L  C  G +  + G    ++     S  C  G TC     S  CQ
Sbjct: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138

Query: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381
           K         P C RG H    G RC+  + CA       P  E   +   C    G   
Sbjct: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195

Query: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407
           C+                                  C+ G+  +  +  C DV+ECQ  P
Sbjct: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255

Query: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461
           G   G  C N +GS+ C C VG RLS    +CED     C S      C+ + A  Y   
Sbjct: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315

Query: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505
           QC C RG   +         + E   P G +    +C+ R   +P            GS 
Sbjct: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369

Query: 506 QCSCPSSGYRLAPNGRNC-------------------QDIDECVTGIHNCSINETCFNIQ 546
               P    RL P+G +                    Q ID C     N  +N  C    
Sbjct: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC-RHFTNLCLNGRCLPTP 428

Query: 547 GGFRCLAFECPENYRRSA------ATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP 600
             +RC   EC   Y +           C   PCH   +C  +P   TY+   +P      
Sbjct: 429 SSYRC---ECNVGYTQDVRGECIDVDECTSSPCHHG-DCVNIP--GTYHCRCYPG----- 477

Query: 601 AVVFRMGPSSAVPGDSMQLAITGG--------NEEGFF 630
              F+  P+     D  +  ++GG        N EG F
Sbjct: 478 ---FQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 105/423 (24%), Positives = 142/423 (33%), Gaps = 87/423 (20%)

Query: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238
           C++ C +       +C+C  G    S GVS    C     C+ G  +CR G SC+   G 
Sbjct: 86  CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141

Query: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289
               C +   D  C  G      N C     C  G     C  D+    C   +G   C+
Sbjct: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197

Query: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
            +L   +G +      C  +     +  PC +            C      C RG+  N 
Sbjct: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240

Query: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409
               C DVDEC      C +G  CVN  GSF C C  G+     S  C D      +   
Sbjct: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298

Query: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455
           L G +C   L  +     C C  G R    G   E      S+   Q CA          
Sbjct: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357

Query: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496
                      N  G      R     SD  G+        +I    L     IC +   
Sbjct: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417

Query: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
                RC+  P S++C C + GY     G  C D+DEC +    C   + C NI G + C
Sbjct: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472

Query: 552 LAF 554
             +
Sbjct: 473 RCY 475


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  228 bits (580), Expect = 2e-59
 Identities = 159/452 (35%), Positives = 211/452 (46%), Gaps = 93/452 (20%)

Query: 164  IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
            I E++EEQ  P  +          DRC  G     GP    C +  D   C C  GYQL 
Sbjct: 822  IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879

Query: 209  SDGVSCEDVNECI-------------TGSHSCRL-------------------------- 229
                 C D NEC+              GS+SC                            
Sbjct: 880  PSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGV 939

Query: 230  --GESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287
              G  C NT GS+ C+    C  GY +     C+DI+EC        PD  C N+ GS+ 
Sbjct: 940  CSGGQCTNTEGSYHCE----CDQGYIMVRKGHCQDINECRH--PGTCPDGRCVNSPGSYT 993

Query: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347
            C   L C+ G+ +   G+C+D+NECL+    C  G  C N EGS+ C     +C +GY +
Sbjct: 994  C---LACEEGY-RGQSGSCVDVNECLT-PGVCAHG-KCTNLEGSFRC-----SCEQGYEV 1042

Query: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQRY 406
              +   C DVDECA  A  C  G  C+N+ GSF C  C+ GY+ +     C D++EC  +
Sbjct: 1043 TSDEKGCQDVDECASRAS-CPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDEC-AF 1099

Query: 407  PGRLCGHKCENTLGSYLC-SCSVGFRLSVDGRSCEDINEC---SSSPCSQECANVYGSYQ 462
            PG      C NT GS+ C  C  G+R S  G SCED++EC    SS    EC N  GSYQ
Sbjct: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159

Query: 463  CYCRRGYQLSDVDGVTCEDIDECALPTGGHICS--YRCINIPGSFQCSCPSSGYRLAPNG 520
            C C +G+QL+  +G  CED++EC    G   C+    C+N  GSF C C + G+  A  G
Sbjct: 1160 CLCPQGFQLA--NGTVCEDVNEC---MGEEHCAPHGECLNSHGSFFCLC-APGFVSAEGG 1213

Query: 521  RNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
             +CQD+DEC T   +  +   C N +G F CL
Sbjct: 1214 TSCQDVDECAT--TDPCVGGHCVNTEGSFNCL 1243



 Score =  222 bits (566), Expect = 8e-58
 Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)

Query: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            + C   G C   +C +      CSC  GY++ SD   C+DV+EC + + SC  G  C+NT
Sbjct: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069

Query: 237  VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
             GSF C   S+C  GY + ED  +C+D+DEC        P  +C NT GSF C+    C 
Sbjct: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121

Query: 296  SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
             G+    LG +C D++EC    + C +G  C NT GSY C      C +G+ L   GT C
Sbjct: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174

Query: 355  VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
             DV+EC    E C     C+NS GSF C C  G+        C DV+EC      + GH 
Sbjct: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232

Query: 415  CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
            C NT GS+ C C  GF+ S +   C DI+EC     P   + +C N  GSY+C   C+ G
Sbjct: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292

Query: 469  YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
            + ++      C DIDECA  T  G H     C N  GSF+C C   G+ ++P+G +C D+
Sbjct: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346

Query: 527  DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
            +EC   +  C     C N++G F CL     E Y
Sbjct: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379



 Score =  208 bits (530), Expect = 1e-53
 Identities = 141/379 (37%), Positives = 193/379 (50%), Gaps = 41/379 (10%)

Query: 212  VSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGI 270
            +S   ++ C  G+ +     +C+N    +RC     C  GY+L    + C D +EC    
Sbjct: 840  LSTPGIDRCAAGATNVCGPGTCVNLPDGYRCV----CSPGYQLHPSQAYCTDDNECLRD- 894

Query: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG---NCIDINECLSISAPCPIGHTCIN 327
              C     C N +GS+ C     C  G+     G    C DINEC      C  G  C N
Sbjct: 895  -PCKGKGRCINRVGSYSCF----CYPGYTLATSGATQECQDINECEQPGV-CS-GGQCTN 947

Query: 328  TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKT 386
            TEGSY C+     C +GY +  +G  C D++EC  P   C  G RCVNSPGS+ C  C+ 
Sbjct: 948  TEGSYHCE-----CDQGYIMVRKG-HCQDINECRHPGT-CPDG-RCVNSPGSYTCLACEE 999

Query: 387  GYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
            GY   G S  CVDVNEC   PG +C H KC N  GS+ CSC  G+ ++ D + C+D++EC
Sbjct: 1000 GYR--GQSGSCVDVNECLT-PG-VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055

Query: 446  SS--SPCSQECANVYGSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
            +S  S  +  C N  GS+ C  C  GY +++ DG  CED+DECA P  G   S  C N  
Sbjct: 1056 ASRASCPTGLCLNTEGSFACSACENGYWVNE-DGTACEDLDECAFP--GVCPSGVCTNTA 1112

Query: 503  GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
            GSF C     GYR +P G +C+D+DEC     +C +   C N  G ++CL   CP+ ++ 
Sbjct: 1113 GSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL---CPQGFQL 1168

Query: 563  SAATRCERL-PCHENRECS 580
            +  T CE +  C     C+
Sbjct: 1169 ANGTVCEDVNECMGEEHCA 1187



 Score =  186 bits (473), Expect = 5e-47
 Identities = 149/474 (31%), Positives = 202/474 (42%), Gaps = 98/474 (20%)

Query: 178  DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
            D C   G C    C +T     C  C  GY+    G SCEDV+EC     SC LG  C N
Sbjct: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153

Query: 236  TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
            TVGS++C     C  G++L     C+D++EC  G  +C P   C N+ GSF C     C 
Sbjct: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204

Query: 296  SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
             GF+    G +C D++EC +   PC  GH C+NTEGS+ C      C  G+  + E   C
Sbjct: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257

Query: 355  VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
            VD+DEC    +P     +C NSPGS+RC   C+ G++    +  C+D++EC      +CG
Sbjct: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314

Query: 413  HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
                C+NT GS+ C C  GF +S  G  C D+NEC    + C    C NV GS+ C C  
Sbjct: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374

Query: 468  GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
              +  D     C       + + E   PTG H  +   ++      G   CS        
Sbjct: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432

Query: 509  ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
                              CPS        + P+G+                 D DECV  
Sbjct: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492

Query: 533  IHNCSINETCFNIQGGFRCLAFECPENYRRSAATR-------CERLPCHENREC 579
                  N  C N   G+ CL   C   +   A+ +       C+ L C EN EC
Sbjct: 1493 GPGLCPNGRCLNTVPGYVCL---CNPGFHYDASHKKCEDHDECQDLAC-ENGEC 1542



 Score =  115 bits (288), Expect = 1e-25
 Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)

Query: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
            D C    PC    C +T     C C  G+Q   +   C D++EC   G   C   + C N
Sbjct: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278

Query: 236  TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
            + GS+RC     C  G+ +  +  C DIDEC +    C     C NT GSFRC     C 
Sbjct: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331

Query: 296  SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
             GF I  +  +C+D+NEC  + A C     C N EGS+   C  ++     +  H    G
Sbjct: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390

Query: 352  TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
                 + E        AP    C  G +    C +  G       C C  G  +     +
Sbjct: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450

Query: 397  C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
            C                                 D +EC  +   LC + +C NT+  Y+
Sbjct: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510

Query: 424  CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
            C C+ GF      + CED +EC    C   EC N  GS+ C+C     L D+    C + 
Sbjct: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569

Query: 483  DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
                     H     IC  +  N      CS P  G+R       CQD
Sbjct: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)

Query: 364  AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
            AE CG     +  RCV     + C+C  G+  D     CVDVNEC     P  LC H  C
Sbjct: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793

Query: 416  ENTLGSYLCSCSVGF 430
            ENT GSY C CS G+
Sbjct: 1794 ENTEGSYRCHCSPGY 1808



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)

Query: 325  CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
            C+     YTC     +C  G+ L+     CVDV+EC     PA  C  G+ C N+ GS+R
Sbjct: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801

Query: 382  CECKTGY 388
            C C  GY
Sbjct: 1802 CHCSPGY 1808



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)

Query: 390  FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
            F+G+ +  C  +N C+         +C      Y C C  GF+L     +C D+NEC   
Sbjct: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781

Query: 447  SSPC----SQECANVYGSYQCYCRRGY 469
            + P        C N  GSY+C+C  GY
Sbjct: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)

Query: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
           +++ APCP          S   +     C +GY  LN   T C D++EC        K  
Sbjct: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635

Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
            CVN+ GS+ C C+ G   D     CV         G      C  +LG   C+  +  R
Sbjct: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690

Query: 432 LSVDGRSCEDINECSSSPCSQ 452
           ++     C  + +   S C +
Sbjct: 691 ITKQICCCSRVGKAWGSECEK 711



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)

Query: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
           +L+C  G+ +  L +C DINECL++   C     C+NT GSY C      C  G  L+  
Sbjct: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657

Query: 351 GTRCV 355
            +RCV
Sbjct: 658 RSRCV 662



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)

Query: 251  GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
            G+E  +   C  ++ CE+G         C      + C     C  GF  DA    C+D+
Sbjct: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775

Query: 310  NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
            NEC  ++ P   C  G+ C NTEGSY C     +C  GY
Sbjct: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
            +C    +   C CF G+QL +  ++C DVNEC  + G     +   C NT GS+RC    
Sbjct: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803

Query: 247  SCGTGY 252
             C  GY
Sbjct: 1804 -CSPGY 1808



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)

Query: 434  VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
            +    C  +N C +      C  V   Y C C  G+QL D   + C D++EC    G  +
Sbjct: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786

Query: 494  CSYR--CINIPGSFQCSCPSSGY 514
                  C N  GS++C C S GY
Sbjct: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 14/138 (10%)

Query: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
           +PC    A+ V  + Q  C +GY+  ++    C+DI+EC   T G      C+N  GS+ 
Sbjct: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645

Query: 507 CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAAT 566
           C+C   G  L P+   C   D+ ++      +   C+   G   C         ++    
Sbjct: 646 CTC-RPGLMLDPSRSRCVS-DKAIS-----MLQGLCYRSLGPGTCTLPLAQRITKQICC- 697

Query: 567 RCERLPCHENRECSKLPL 584
            C R+      EC K PL
Sbjct: 698 -CSRVGKAWGSECEKCPL 714



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)

Query: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
           C+DINEC +    +  EC N  GSY C CR G  L
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
           C  GY+ L+    C+D+NEC+T    C+  E C+NT GS+ C    +C  G  L    S 
Sbjct: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659

Query: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
                C S     +   +C  +LG   C
Sbjct: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 11/87 (12%)

Query: 248 CGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI 307
           C  GY+      C+DI+EC +       D  C NT GS+ C     C+ G + D      
Sbjct: 608 CPQGYKRLNLTHCQDINECLT--LGLCKDAECVNTRGSYLC----TCRPGLMLDP----- 656

Query: 308 DINECLSISAPCPIGHTCINTEGSYTC 334
             + C+S  A   +   C  + G  TC
Sbjct: 657 SRSRCVSDKAISMLQGLCYRSLGPGTC 683


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  215 bits (548), Expect = 9e-56
 Identities = 133/358 (37%), Positives = 179/358 (50%), Gaps = 43/358 (12%)

Query: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESCINTVG 238
           C  GG C       G    C C  G+Q    G  C+ DV+EC T +  C+    C+NT G
Sbjct: 133 CFHGGRCVP-----GSAQPCHCPPGFQ----GPRCQYDVDECRTHNGGCQ--HRCVNTPG 181

Query: 239 SFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
           S+ C+    C  G+ L T+  +C  I+ C  G   C    + Q T+   RC    QC+ G
Sbjct: 182 SYLCE----CKPGFRLHTDSRTCLAINSCALGNGGCQHHCV-QLTITRHRC----QCRPG 232

Query: 298 F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356
           F +Q+   +C+  + C + +  C   H C    G   C+     C  GY L  +G  C D
Sbjct: 233 FQLQEDGRHCVRRSPCANRNGSCM--HRCQVVRGLARCE-----CHVGYQLAADGKACED 285

Query: 357 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVD-----VNECQRYPGRLC 411
           VDECA     C   H C+N+ GSF+C C  GY      R C       VN C+   G  C
Sbjct: 286 VDECAAGLAQCA--HGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGG-C 342

Query: 412 GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE-CANVYGSYQCYCRRGYQ 470
            H C +T    LC+C  G+ L  D R+C D+++C+ SPC Q+ C N  G Y+C C  GY+
Sbjct: 343 SHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYR 402

Query: 471 LSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE 528
           LS  DG  CED+DECA   GG  C + C N+ GSFQCSC  +GYRL  + R C  ++E
Sbjct: 403 LS-ADGCGCEDVDECASSRGG--CEHHCTNLAGSFQCSC-EAGYRLHEDRRGCSPLEE 456



 Score =  180 bits (456), Expect = 4e-45
 Identities = 112/309 (36%), Positives = 146/309 (47%), Gaps = 35/309 (11%)

Query: 262 DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCP 320
           D+DEC +  HN      C NT GS+ C    +CK GF +      C+ IN C   +  C 
Sbjct: 161 DVDECRT--HNGGCQHRCVNTPGSYLC----ECKPGFRLHTDSRTCLAINSCALGNGGCQ 214

Query: 321 IGHTCIN-TEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379
             H C+  T   + CQ     C  G+ L E+G  CV    CA     C   HRC    G 
Sbjct: 215 --HHCVQLTITRHRCQ-----CRPGFQLQEDGRHCVRRSPCANRNGSCM--HRCQVVRGL 265

Query: 380 FRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439
            RCEC  GY      + C DV+EC     + C H C NT GS+ C C  G+ L  DGR C
Sbjct: 266 ARCECHVGYQLAADGKACEDVDECAAGLAQ-CAHGCLNTQGSFKCVCHAGYELGADGRQC 324

Query: 440 -----EDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
                E +N C ++   CS  C++      C C RGY+L D D  TC D+D+CA      
Sbjct: 325 YRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYEL-DTDQRTCIDVDDCA---DSP 380

Query: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
            C   C N PG ++C C  +GYRL+ +G  C+D+DEC +    C     C N+ G F+C 
Sbjct: 381 CCQQVCTNNPGGYECGC-YAGYRLSADGCGCEDVDECASSRGGC--EHHCTNLAGSFQC- 436

Query: 553 AFECPENYR 561
              C   YR
Sbjct: 437 --SCEAGYR 443



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 138/573 (24%), Positives = 192/573 (33%), Gaps = 136/573 (23%)

Query: 73  LEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMV 132
           L    C  G  LA +   C     ++    A  + +C H CL       QG S +     
Sbjct: 265 LARCECHVGYQLAADGKAC-----EDVDECAAGLAQCAHGCL-----NTQG-SFKCVCHA 313

Query: 133 GYQCGQVFRAC------CVKSQETGD---------LDVGGLQETDKIIEVEEEQEDPYLN 177
           GY+ G   R C       V S E  +            G L    +  E++ +Q      
Sbjct: 314 GYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDV 373

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           D C     C+Q C +      C C+ GY+L +DG  CEDV+EC +    C     C N  
Sbjct: 374 DDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE--HHCTNLA 431

Query: 238 GSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
           GSF+C    SC  GY L ED   C  ++E    +   LP F+        R  P +    
Sbjct: 432 GSFQC----SCEAGYRLHEDRRGCSPLEEPMVDLDGELP-FV--------RPLPHI---- 474

Query: 297 GFIQDALGNCIDINECLSISAPCPI--GHT------CINTEGSYTCQKNVPNCGRGYHLN 348
             +QD L      ++  +      +   HT      C++    + C     +C  G    
Sbjct: 475 AVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNG---- 530

Query: 349 EEGTRCVDVDECAPP-----------AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397
             GT  + +D C  P             P   G  C     SF C C+ G   D ++  C
Sbjct: 531 --GTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNC-----SFSCSCQNGGTCDSVTGAC 583

Query: 398 -----VDVNECQ-----RYPGRLCGHK--------CENTLGSYLCS-------CSVGFRL 432
                V    C+      Y G+ C  K        C    G+ LC        C +    
Sbjct: 584 RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPP 643

Query: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQC-----------YCRRGY-------QLSDV 474
              G  C +  +C   P +Q C    GS  C            C  GY         +  
Sbjct: 644 WAFGPGCSEECQC-VQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCP 702

Query: 475 DGVTCEDID-ECA--LPTG--GHICSYRC----INIPGSFQCSCPS------SGYRLAPN 519
            GV C+ +  EC    P G  G  C   C      +  S  CSC        +G    P 
Sbjct: 703 VGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPP 762

Query: 520 GRNCQDID-ECVTGIHNCSINETCFNIQGGFRC 551
           GR  +D + +C  G       E C   Q   RC
Sbjct: 763 GRTGEDCEADCPEGRWGLGCQEICPACQHAARC 795



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 131/585 (22%), Positives = 184/585 (31%), Gaps = 128/585 (21%)

Query: 45   THQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEAT 104
            T  K+CS         C       C S      C  G+S  N +D C  P G        
Sbjct: 559  TFGKNCSF-------SCSCQNGGTCDSVTGACRCPPGVSGTNCEDGC--PKG-------Y 602

Query: 105  FVKRC---CHCCLLGRAAQAQGQS-CEYSLMVGY------------------QCGQVFRA 142
            + K C   C+C   GR  +  G   C+  L   +                  QC Q    
Sbjct: 603  YGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQ 662

Query: 143  CCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCF 202
             C K   +     G                  +  +RC+    C+      G    C+C 
Sbjct: 663  SCDKRDGSCSCKAG------------------FRGERCQA--ECELGYFGPGCWQACTCP 702

Query: 203  VGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF--RCQRDSSCGTG--YELTEDN 258
            VG  +  D VS E    C  G      G+ C   VG+F   C    SCG    + +T   
Sbjct: 703  VG--VACDSVSGECGKRCPAGFQGEDCGQEC--PVGTFGVNCSSSCSCGGAPCHGVTGQC 758

Query: 259  SC------KDID-ECESGIHNCLPDFICQNTLGSFRCRPK---LQCKSGFIQDALGNCID 308
             C      +D + +C  G        IC     + RC P+     C  GF+      C D
Sbjct: 759  RCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVG---SRCQD 815

Query: 309  INECLSISAPCPIGHTCIN------TEGSYTCQKNVP--NCGRGYHLNEEGTRCVDVDEC 360
            +         C    +C N        G  +C       +C R       G  C     C
Sbjct: 816  VCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNC 875

Query: 361  APPAEPCGK-GHRCVNSPGSF--RCE--CKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
            +     C      C+   G    RCE  C  G++  G  + C    +CQ       G  C
Sbjct: 876  SAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRC----QCQH------GAAC 925

Query: 416  ENTLGSYLCSCSVGFRLSVDGRSCE------DINECSSSPCSQECANVYGSYQCYCRRGY 469
            ++  G+  C+C  G+R +    +C       D     +      C  V GS  C C  G 
Sbjct: 926  DHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGS--CLCPAGR 981

Query: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
            +     G  C   + C   T GH CS  C    G+  C         AP       +  C
Sbjct: 982  R-----GPRC--AETCPAHTYGHNCSQACACFNGA-SCDPVHGQCHCAPGWMGPSCLQAC 1033

Query: 530  VTGIHNCSINETCFNIQGGFRCLAFE----CPENYRRSAATRCER 570
              G++  +   +C   Q G  C        CPE +   A   CE+
Sbjct: 1034 PAGLYGDNCRHSCL-CQNGGTCDPVSGHCACPEGW---AGLACEK 1074



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 111/506 (21%), Positives = 160/506 (31%), Gaps = 123/506 (24%)

Query: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC--EDVNECITGSHSCRLGESCIN 235
            D CR GG C            C C  G+  L    +C  +   +  + S SC+ G +C +
Sbjct: 525  DDCRNGGTCLLGLDG------CDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDS 578

Query: 236  TVGSFRC-------QRDSSCGTGY---ELTEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
              G+ RC         +  C  GY      +  +C +   C      CL D         
Sbjct: 579  VTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCH 638

Query: 286  FRCRP--------------------------KLQCKSGFIQDALGNCIDIN----ECLSI 315
              C P                             CK+GF  +      ++      C   
Sbjct: 639  LTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQ- 697

Query: 316  SAPCPIGHTCINTEGSYTCQKNVP------NCGRGYHLNEEGTRCVDVDECAPPAEPC-G 368
            +  CP+G  C +  G   C K  P      +CG+   +   G  C     C+    PC G
Sbjct: 698  ACTCPVGVACDSVSGE--CGKRCPAGFQGEDCGQECPVGTFGVNC--SSSCSCGGAPCHG 753

Query: 369  KGHRCVNSPG----SFRCECKTGYYFDGISRMC----------VDVNECQRYPGRLCGHK 414
               +C   PG        +C  G +  G   +C           +   C   PG   G +
Sbjct: 754  VTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPG-FVGSR 812

Query: 415  CENT--LGSYLCSCSVGFRLSVDGRSCEDINECSSSP------CSQECANVYG----SYQ 462
            C++    G Y  SC      + DG        CS +P      C + C   +     S+ 
Sbjct: 813  CQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHP 872

Query: 463  CYCRRGYQLSDV-----------DGVTCEDIDECALPTGGHICSYRCINIPG------SF 505
            C C  G+   D             G  CE   +C     G  C  RC    G      S 
Sbjct: 873  CNCSAGHGSCDAISGLCLCEAGYVGPRCE--QQCPQGHFGPGCEQRCQCQHGAACDHVSG 930

Query: 506  QCSCPSSGYR------LAPN---GRNCQDIDECVTGIHNCSINETCFNIQG--GFRCLAF 554
             C+CP +G+R        P    G +C+    C  G    ++N +C    G  G RC A 
Sbjct: 931  ACTCP-AGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRC-AE 988

Query: 555  ECP-ENYRRSAATRCERLPCHENREC 579
             CP   Y  + +  C    C     C
Sbjct: 989  TCPAHTYGHNCSQAC---ACFNGASC 1011



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 130/588 (22%), Positives = 167/588 (28%), Gaps = 149/588 (25%)

Query: 61   CRMVQEQCCHSQLEELHCA---TGISLANEQD------------RCATPHGDNASL---- 101
            C    +  CH       CA   TG S     D             C+  HG   ++    
Sbjct: 830  CSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLC 889

Query: 102  --EATFV-KRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGL 158
              EA +V  RC   C  G       Q C+     G  C  V  AC   +   G       
Sbjct: 890  LCEAGYVGPRCEQQCPQGHFGPGCEQRCQ--CQHGAACDHVSGACTCPAGWRGTF----- 942

Query: 159  QETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN 218
                     E      +    CR    C            C C  G +    G  C +  
Sbjct: 943  --------CEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRR----GPRCAETC 990

Query: 219  ECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH--NCLPD 276
               T  H+C    +C N            C  G+      SC  +  C +G++  NC   
Sbjct: 991  PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGW---MGPSC--LQACPAGLYGDNCRHS 1045

Query: 277  FICQN------TLGSFRCR---PKLQC-KSGFIQDALGNCIDINECLSISAPCPIGHTCI 326
             +CQN        G   C      L C K    +D    C     CL+     P    C+
Sbjct: 1046 CLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCL 1105

Query: 327  NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC--------------GKGHR 372
               G +T  K    C RG+     G  C     C PP   C              G G  
Sbjct: 1106 CPAG-WTGDKCQSPCLRGWF----GEACAQRCSC-PPGAACHHVTGACRCPPGFTGSGCE 1159

Query: 373  CVNSPGSF----------------------RCECKTGYYFDGISRMCVDVN---ECQRYP 407
                PGSF                       C C  GY+     + C        C++  
Sbjct: 1160 QACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLC 1219

Query: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR 467
            G L G  C+   G+  C C  GF     G  C     C        C +V     C C +
Sbjct: 1220 GCLNGGSCDAATGA--CRCPTGFL----GTDCN--LTCPQGRFGPNCTHV-----CGCGQ 1266

Query: 468  GYQLSDVDGVTCEDIDECALPTG--GHICSYRC----INIPGSFQCSCPSSGYRLAPN-- 519
            G     V G        C  P G  G  C   C      +     CSC + G   A N  
Sbjct: 1267 GAACDPVTGT-------CLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGS 1319

Query: 520  --------GRNCQDIDECVTGIH--------NCSINETCFNIQGGFRC 551
                    GR+C+    C  G +        +C  N TC    G  RC
Sbjct: 1320 CSCGLGWTGRHCE--LACPPGRYGAACHLECSCHNNSTCEPATGTCRC 1365



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 108/446 (24%), Positives = 145/446 (32%), Gaps = 103/446 (23%)

Query: 180  CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS--HSCRLGESCINTV 237
            C+ GG C            C+C  G+     G++CE   EC+       CR    C+N  
Sbjct: 1048 CQNGGTCDPVSGH------CACPEGWA----GLACE--KECLPRDVRAGCRHSGGCLN-- 1093

Query: 238  GSFRCQRDSSCGTGYELTEDNSCKD------IDECESGIHNCLPDFICQNTLGSFRCRPK 291
            G         C      T D  C+         E  +   +C P   C +  G+ RC P 
Sbjct: 1094 GGLCDPHTGRCLCPAGWTGDK-CQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPG 1152

Query: 292  LQ---CKSGFIQDALG-NCIDINECLSISAPC-PIGHTCINTEGSYTCQKNVPNCGRGYH 346
                 C+      + G +C  + +C   +  C P   TC              +C  GYH
Sbjct: 1153 FTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC--------------SCAAGYH 1198

Query: 347  LNEEGTRCVDVDECAPPAEP---CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
                  RC       P  E    C  G  C  + G+  C C TG+     +  C      
Sbjct: 1199 GPSCQQRC-PPGRYGPGCEQLCGCLNGGSCDAATGA--CRCPTGFLGTDCNLTCP----- 1250

Query: 404  QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRS---CEDINECSSSPCSQECANVYGS 460
            Q   G  C H C    G+  C    G  L   GR+   CE         C Q    V   
Sbjct: 1251 QGRFGPNCTHVCGCGQGA-ACDPVTGTCLCPPGRAGVRCE-------RGCPQNRFGVGCE 1302

Query: 461  YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF------QCSC----- 509
            + C CR G  L      +C     C L   G  C   C   PG +      +CSC     
Sbjct: 1303 HTCSCRNG-GLCHASNGSC----SCGLGWTGRHCELAC--PPGRYGAACHLECSCHNNST 1355

Query: 510  --PSSG-YRLAPN--GRNCQDIDECVTGIHNCSINETCFNIQG------GFRCLAFECPE 558
              P++G  R  P   G+ C+    C  G H       C+   G        RCL   CP 
Sbjct: 1356 CEPATGTCRCGPGFYGQACE--HPCPPGFHGAGCQGLCWCQHGAPCDPISGRCL---CPA 1410

Query: 559  NYRRSAATR-CE----RLPCHENREC 579
             +      R CE       CH+  +C
Sbjct: 1411 GFHGHFCERGCEPGSFGEGCHQRCDC 1436


>gi|190343004 EGF-containing fibulin-like extracellular matrix
           protein 2 [Homo sapiens]
          Length = 443

 Score =  215 bits (547), Expect = 1e-55
 Identities = 150/467 (32%), Positives = 211/467 (45%), Gaps = 94/467 (20%)

Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ----------- 293
           + C  GYE   D+  C+D++EC +    C  +  C N  G + C P+             
Sbjct: 37  TECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGP 96

Query: 294 ------------CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
                       C  G+  D   +C+D++EC      C     C N  GSY C      C
Sbjct: 97  PPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC-----TC 151

Query: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
             GY   + G  CVD+DEC      C   HRCVN PGSFRC+C+ G+     +R CVDVN
Sbjct: 152 PDGYR--KIGPECVDIDECR--YRYCQ--HRCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205

Query: 402 ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYG 459
           EC    G  C  +C N+ G++LC C  G+ L  DG SC DI+ECS S   C   C N  G
Sbjct: 206 ECDM--GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPG 263

Query: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS--YRCINIPGSFQCSCPSSGYRLA 517
            + C+C +GYQL  +    C+DIDEC   +G H CS    C+N  G         GYR  
Sbjct: 264 RFSCHCPQGYQL--LATRLCQDIDEC--ESGAHQCSEAQTCVNFHG---------GYR-- 308

Query: 518 PNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENR 577
                C D + CV      S N          RCL   CP +                N 
Sbjct: 309 -----CVDTNRCVEPYIQVSEN----------RCL---CPAS----------------NP 334

Query: 578 ECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSP 637
            C + P  I + +++  +    PA VF++  +S  PG      I  GN +G F  R+++ 
Sbjct: 335 LCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINN 394

Query: 638 HSGVVALTKPVPEPRDLLLTVKMDLSRHGTVS---SFVAKLFIFVSA 681
            S ++ L +PV  PR+ +L ++M ++ +  +S   S V +L +FV A
Sbjct: 395 VSAMLVLARPVTGPREYVLDLEM-VTMNSLMSYRASSVLRLTVFVGA 440



 Score =  171 bits (432), Expect = 3e-42
 Identities = 104/292 (35%), Positives = 140/292 (47%), Gaps = 50/292 (17%)

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------------------ 242
           C  GY+   D   C DVNEC+T   +C+    CIN  G + C                  
Sbjct: 39  CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98

Query: 243 -----QRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
                Q  + C  GYE  + +SC D+DEC   +H+C P   C N  GS++C     C  G
Sbjct: 99  PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQC----TCPDG 154

Query: 298 FIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
           + +     C+DI+EC          H C+N  GS+ CQ     C  G+ L      CVDV
Sbjct: 155 Y-RKIGPECVDIDECRYRYCQ----HRCVNLPGSFRCQ-----CEPGFQLGPNNRSCVDV 204

Query: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQRYPGRLCGHKC 415
           +EC   A PC +  RC NS G+F C C  GY  + DG S  C D++EC  Y   LC ++C
Sbjct: 205 NECDMGA-PCEQ--RCFNSYGTFLCRCHQGYELHRDGFS--CSDIDECS-YSSYLCQYRC 258

Query: 416 ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSS--PCS--QECANVYGSYQC 463
            N  G + C C  G++L +  R C+DI+EC S    CS  Q C N +G Y+C
Sbjct: 259 VNEPGRFSCHCPQGYQL-LATRLCQDIDECESGAHQCSEAQTCVNFHGGYRC 309



 Score =  103 bits (257), Expect = 5e-22
 Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 6/130 (4%)

Query: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
           + C  G PC+Q+C ++    +C C  GY+L  DG SC D++EC   S+ C+    C+N  
Sbjct: 205 NECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQY--RCVNEP 262

Query: 238 GSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297
           G F C     C  GY+L     C+DIDECESG H C     C N  G +RC    +C   
Sbjct: 263 GRFSCH----CPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEP 318

Query: 298 FIQDALGNCI 307
           +IQ +   C+
Sbjct: 319 YIQVSENRCL 328



 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 61/179 (34%), Positives = 78/179 (43%), Gaps = 34/179 (18%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C+ +C +      C C  G+QL  +  SC DVNEC  G+  C   + C N+ G+F C+  
Sbjct: 173 CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGA-PCE--QRCFNSYGTFLCR-- 227

Query: 246 SSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
             C  GYEL  D  SC DIDEC    + C   + C N  G F C     C  G+   A  
Sbjct: 228 --CHQGYELHRDGFSCSDIDECSYSSYLC--QYRCVNEPGRFSC----HCPQGYQLLATR 279

Query: 305 NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
            C DI+EC S +  C    TC+N  G Y                    RCVD + C  P
Sbjct: 280 LCQDIDECESGAHQCSEAQTCVNFHGGY--------------------RCVDTNRCVEP 318


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  213 bits (543), Expect = 4e-55
 Identities = 149/461 (32%), Positives = 214/461 (46%), Gaps = 56/461 (12%)

Query: 243  QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
            + +  C  G+EL    + C D DEC  G   C     C N  G F C     C +GF   
Sbjct: 3423 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 3473

Query: 302  ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
            AL     NC D++EC   +  C  G  C+N  GSY C   +P+CG G+ +  +G  C DV
Sbjct: 3474 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 3529

Query: 358  DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
            DEC    + C     C N+PG  RC C  GY   G S  C+DVNEC + P + C ++C N
Sbjct: 3530 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 3588

Query: 418  TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
              GSY C C  G  L  DG++C  +     +           P  +  A++ G SY  + 
Sbjct: 3589 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3648

Query: 465  -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
              R G   LS V            +GV C D+DEC +    ++C + C N  GS+QC CP
Sbjct: 3649 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 3704

Query: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCER 570
             +GYRL P+G+NCQDI+EC      C   + CFN +G ++C+   CP  YR+  +     
Sbjct: 3705 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCF 3763

Query: 571  LPCHENREC-SKLPLRITYYHLSFPTNIQAPAVVFRMGPSS--AVPGDSMQLAITGGNEE 627
              C  +++C +  P  + Y  L  P  ++A   V R+   S   VP +  +L++   +  
Sbjct: 3764 RRC--SQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPANRTELSMLEPDPR 3821

Query: 628  GFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTV 668
              F  R +    G V   + +       LTV+    RH +V
Sbjct: 3822 SPFALRPLRAGLGAVYTRRALTRAGLYRLTVRAAAPRHQSV 3862



 Score =  182 bits (462), Expect = 9e-46
 Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)

Query: 178  DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C GG  PC   C +      C+C  G+ L  D  +C DV+EC   +H CR G+ C+N 
Sbjct: 3445 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 3504

Query: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            +GS+RC  D  CG G+ + +   C+D+DEC  G+ +C  + +C+NT G  RC     C  
Sbjct: 3505 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 3558

Query: 297  GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            G+ +Q     C+D+NECL +   C   + C N +GSY C      C  G  L  +G  C 
Sbjct: 3559 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 3611

Query: 356  DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
             ++                    P A   G  +    S  PG        R  C  G+  
Sbjct: 3612 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 3671

Query: 391  DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
               + +C D++EC+     LC H C NT GSY C C  G+RL   G++C+DINEC   S 
Sbjct: 3672 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 3727

Query: 449  PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
             C   Q C N  GSYQC    C   Y+     G       +     G     YR + +P
Sbjct: 3728 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 3786



 Score =  157 bits (398), Expect = 2e-38
 Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)

Query: 195  DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
            +E    C  G++L S G  C D +EC  G   C    +C+N  G F C    +C TG+ L
Sbjct: 3422 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 3475

Query: 255  T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
              +D +C+D+DEC    H C     C N LGS+RC P   C  GF + D  G C D++EC
Sbjct: 3476 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 3532

Query: 313  LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
            L     C     C NT G + C     +C RGY +      C+DV+EC    + C   ++
Sbjct: 3533 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 3585

Query: 373  CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
            C N  GS+RC C  G       + C  +                          PG    
Sbjct: 3586 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 3644

Query: 413  HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
            H   +     +   SVG      G       C D++EC   + C   C N  GSYQC C 
Sbjct: 3645 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 3704

Query: 467  RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
             GY+L    G  C+DI+EC   +        C N  GS+QC    CP++ YR  P+   C
Sbjct: 3705 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 3762

Query: 524  --QDIDECVTG 532
              +   +C TG
Sbjct: 3763 FRRCSQDCGTG 3773


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  213 bits (543), Expect = 4e-55
 Identities = 149/461 (32%), Positives = 214/461 (46%), Gaps = 56/461 (12%)

Query: 243  QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
            + +  C  G+EL    + C D DEC  G   C     C N  G F C     C +GF   
Sbjct: 4614 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 4664

Query: 302  ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
            AL     NC D++EC   +  C  G  C+N  GSY C   +P+CG G+ +  +G  C DV
Sbjct: 4665 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 4720

Query: 358  DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
            DEC    + C     C N+PG  RC C  GY   G S  C+DVNEC + P + C ++C N
Sbjct: 4721 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 4779

Query: 418  TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
              GSY C C  G  L  DG++C  +     +           P  +  A++ G SY  + 
Sbjct: 4780 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 4839

Query: 465  -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
              R G   LS V            +GV C D+DEC +    ++C + C N  GS+QC CP
Sbjct: 4840 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 4895

Query: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCER 570
             +GYRL P+G+NCQDI+EC      C   + CFN +G ++C+   CP  YR+  +     
Sbjct: 4896 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCF 4954

Query: 571  LPCHENREC-SKLPLRITYYHLSFPTNIQAPAVVFRMGPSS--AVPGDSMQLAITGGNEE 627
              C  +++C +  P  + Y  L  P  ++A   V R+   S   VP +  +L++   +  
Sbjct: 4955 RRC--SQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPANRTELSMLEPDPR 5012

Query: 628  GFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTV 668
              F  R +    G V   + +       LTV+    RH +V
Sbjct: 5013 SPFALRPLRAGLGAVYTRRALTRAGLYRLTVRAAAPRHQSV 5053



 Score =  182 bits (462), Expect = 9e-46
 Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)

Query: 178  DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C GG  PC   C +      C+C  G+ L  D  +C DV+EC   +H CR G+ C+N 
Sbjct: 4636 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 4695

Query: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            +GS+RC  D  CG G+ + +   C+D+DEC  G+ +C  + +C+NT G  RC     C  
Sbjct: 4696 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 4749

Query: 297  GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            G+ +Q     C+D+NECL +   C   + C N +GSY C      C  G  L  +G  C 
Sbjct: 4750 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 4802

Query: 356  DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
             ++                    P A   G  +    S  PG        R  C  G+  
Sbjct: 4803 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 4862

Query: 391  DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
               + +C D++EC+     LC H C NT GSY C C  G+RL   G++C+DINEC   S 
Sbjct: 4863 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 4918

Query: 449  PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
             C   Q C N  GSYQC    C   Y+     G       +     G     YR + +P
Sbjct: 4919 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 4977



 Score =  157 bits (398), Expect = 2e-38
 Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)

Query: 195  DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
            +E    C  G++L S G  C D +EC  G   C    +C+N  G F C    +C TG+ L
Sbjct: 4613 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 4666

Query: 255  T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
              +D +C+D+DEC    H C     C N LGS+RC P   C  GF + D  G C D++EC
Sbjct: 4667 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 4723

Query: 313  LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
            L     C     C NT G + C     +C RGY +      C+DV+EC    + C   ++
Sbjct: 4724 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 4776

Query: 373  CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
            C N  GS+RC C  G       + C  +                          PG    
Sbjct: 4777 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 4835

Query: 413  HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
            H   +     +   SVG      G       C D++EC   + C   C N  GSYQC C 
Sbjct: 4836 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 4895

Query: 467  RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
             GY+L    G  C+DI+EC   +        C N  GS+QC    CP++ YR  P+   C
Sbjct: 4896 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 4953

Query: 524  --QDIDECVTG 532
              +   +C TG
Sbjct: 4954 FRRCSQDCGTG 4964


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  213 bits (543), Expect = 4e-55
 Identities = 149/461 (32%), Positives = 214/461 (46%), Gaps = 56/461 (12%)

Query: 243  QRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301
            + +  C  G+EL    + C D DEC  G   C     C N  G F C     C +GF   
Sbjct: 3332 ENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCT----CPTGF--- 3382

Query: 302  ALG----NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
            AL     NC D++EC   +  C  G  C+N  GSY C   +P+CG G+ +  +G  C DV
Sbjct: 3383 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRC---LPDCGPGFRV-ADGAGCEDV 3438

Query: 358  DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
            DEC    + C     C N+PG  RC C  GY   G S  C+DVNEC + P + C ++C N
Sbjct: 3439 DECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLP-KACAYQCHN 3497

Query: 418  TLGSYLCSCSVGFRLSVDGRSCEDINECSSS-----------PCSQECANVYG-SYQCY- 464
              GSY C C  G  L  DG++C  +     +           P  +  A++ G SY  + 
Sbjct: 3498 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3557

Query: 465  -CRRG-YQLSDV------------DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP 510
              R G   LS V            +GV C D+DEC +    ++C + C N  GS+QC CP
Sbjct: 3558 SLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLDECRV---RNLCQHACRNTEGSYQCLCP 3613

Query: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCER 570
             +GYRL P+G+NCQDI+EC      C   + CFN +G ++C+   CP  YR+  +     
Sbjct: 3614 -AGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCF 3672

Query: 571  LPCHENREC-SKLPLRITYYHLSFPTNIQAPAVVFRMGPSS--AVPGDSMQLAITGGNEE 627
              C  +++C +  P  + Y  L  P  ++A   V R+   S   VP +  +L++   +  
Sbjct: 3673 RRC--SQDCGTGGPSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPANRTELSMLEPDPR 3730

Query: 628  GFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTV 668
              F  R +    G V   + +       LTV+    RH +V
Sbjct: 3731 SPFALRPLRAGLGAVYTRRALTRAGLYRLTVRAAAPRHQSV 3771



 Score =  182 bits (462), Expect = 9e-46
 Identities = 116/359 (32%), Positives = 161/359 (44%), Gaps = 51/359 (14%)

Query: 178  DRCRGG-GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C GG  PC   C +      C+C  G+ L  D  +C DV+EC   +H CR G+ C+N 
Sbjct: 3354 DECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNL 3413

Query: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
            +GS+RC  D  CG G+ + +   C+D+DEC  G+ +C  + +C+NT G  RC     C  
Sbjct: 3414 LGSYRCLPD--CGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC----SCPR 3467

Query: 297  GF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            G+ +Q     C+D+NECL +   C   + C N +GSY C      C  G  L  +G  C 
Sbjct: 3468 GYRMQGPSLPCLDVNECLQLPKAC--AYQCHNLQGSYRCL-----CPPGQTLLRDGKACT 3520

Query: 356  DVDE-----------------CAPPAEPCGKGHRCVNS--PGSF------RCECKTGYYF 390
             ++                    P A   G  +    S  PG        R  C  G+  
Sbjct: 3521 SLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIR 3580

Query: 391  DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSS 448
               + +C D++EC+     LC H C NT GSY C C  G+RL   G++C+DINEC   S 
Sbjct: 3581 Q--NGVCTDLDECR--VRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESI 3636

Query: 449  PC--SQECANVYGSYQCY---CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502
             C   Q C N  GSYQC    C   Y+     G       +     G     YR + +P
Sbjct: 3637 ECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGPSTLQYRLLPLP 3695



 Score =  157 bits (398), Expect = 2e-38
 Identities = 116/371 (31%), Positives = 158/371 (42%), Gaps = 52/371 (14%)

Query: 195  DEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL 254
            +E    C  G++L S G  C D +EC  G   C    +C+N  G F C    +C TG+ L
Sbjct: 3331 EENEVGCPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSC----TCPTGFAL 3384

Query: 255  T-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINEC 312
              +D +C+D+DEC    H C     C N LGS+RC P   C  GF + D  G C D++EC
Sbjct: 3385 AWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLP--DCGPGFRVADGAG-CEDVDEC 3441

Query: 313  LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHR 372
            L     C     C NT G + C     +C RGY +      C+DV+EC    + C   ++
Sbjct: 3442 LEGLDDCHYNQLCENTPGGHRC-----SCPRGYRMQGPSLPCLDVNECLQLPKAC--AYQ 3494

Query: 373  CVNSPGSFRCECKTGYYFDGISRMCVDVNE--------------------CQRYPGRLCG 412
            C N  GS+RC C  G       + C  +                          PG    
Sbjct: 3495 CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPG-TSY 3553

Query: 413  HKCENTLGSYLCSCSVGFRLSVDG-----RSCEDINECS-SSPCSQECANVYGSYQCYCR 466
            H   +     +   SVG      G       C D++EC   + C   C N  GSYQC C 
Sbjct: 3554 HAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCP 3613

Query: 467  RGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCPSSGYRLAPNGRNC 523
             GY+L    G  C+DI+EC   +        C N  GS+QC    CP++ YR  P+   C
Sbjct: 3614 AGYRLLP-SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPAT-YRQGPSPGTC 3671

Query: 524  --QDIDECVTG 532
              +   +C TG
Sbjct: 3672 FRRCSQDCGTG 3682


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  207 bits (528), Expect = 2e-53
 Identities = 132/390 (33%), Positives = 179/390 (45%), Gaps = 36/390 (9%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304

Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356

Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466

Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525

Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580

Query: 542 CFNIQGGFRCLAFECPENYRRSA-ATRCER 570
           C N    + C   EC E +R +    RC R
Sbjct: 581 CVNSDDSYTC---ECLEGFRLAEDGKRCRR 607



 Score =  194 bits (493), Expect = 2e-49
 Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345

Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397

Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507

Query: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566

Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621

Query: 542 CFNIQGGFRCLAFECPENY 560
           C N    + C   +C E +
Sbjct: 622 CVNNGNSYIC---KCSEGF 637



 Score =  172 bits (435), Expect = 1e-42
 Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)

Query: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292

Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351

Query: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410

Query: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465

Query: 550 RCLAFECPENY 560
            C   +C E +
Sbjct: 466 VC---QCSEGF 473



 Score =  161 bits (407), Expect = 2e-39
 Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)

Query: 61  CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
           C  ++  C H  +         C  G  L ++Q  C     D  ++E    ++ C     
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299

Query: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
              C C  G A    G+ C   + V Y C      C     E  + D   L +  +   +
Sbjct: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352

Query: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
             +++     D C      C+ +C +T D   C C  G+ L  D  +C  +N C      
Sbjct: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412

Query: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
           C     C+N   S+ C+    C  GY L  +  +C  +D C    H C  + +C NT  S
Sbjct: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464

Query: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
           F C    QC  GF I + L  C  ++ CL     C   ++C+N + S+ CQ     C  G
Sbjct: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513

Query: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
           + L  +G  C  +D CA     C   H CV+S  SF C+C  GY      + C   + CQ
Sbjct: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571

Query: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
                 C H C N+  SY C C  GFRL+ DG+ C   + C S+   C   C N   SY 
Sbjct: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630

Query: 463 CYCRRGYQLSDVDGVTCEDIDE 484
           C C  G+ L++ DG  C+   E
Sbjct: 631 CKCSEGFVLAE-DGRRCKKCTE 651



 Score =  140 bits (353), Expect = 4e-33
 Identities = 87/266 (32%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C+ +C +  +   C C  GY L  +G +C  V+ C    H C   + C+NT  SF CQ  
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468

Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
             C  G+ + ED  +C  +D C    H C  ++ C N   SF C    QC  G +  + G
Sbjct: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520

Query: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  ++ C      C   H+C+++E S+ CQ     C  GY L E+G  C   D C   
Sbjct: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C   H CVNS  S+ CEC  G+      + C   + C+      C H C N   SY+
Sbjct: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKS-THHGCEHICVNNGNSYI 630

Query: 424 CSCSVGFRLSVDGRSCEDINECSSSP 449
           C CS GF L+ DGR C+   +C+  P
Sbjct: 631 CKCSEGFVLAEDGRRCK---KCTEGP 653


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  207 bits (528), Expect = 2e-53
 Identities = 132/390 (33%), Positives = 179/390 (45%), Gaps = 36/390 (9%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304

Query: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356

Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466

Query: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525

Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580

Query: 542 CFNIQGGFRCLAFECPENYRRSA-ATRCER 570
           C N    + C   EC E +R +    RC R
Sbjct: 581 CVNSDDSYTC---ECLEGFRLAEDGKRCRR 607



 Score =  194 bits (493), Expect = 2e-49
 Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345

Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397

Query: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507

Query: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566

Query: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621

Query: 542 CFNIQGGFRCLAFECPENY 560
           C N    + C   +C E +
Sbjct: 622 CVNNGNSYIC---KCSEGF 637



 Score =  172 bits (435), Expect = 1e-42
 Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)

Query: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292

Query: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351

Query: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410

Query: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465

Query: 550 RCLAFECPENY 560
            C   +C E +
Sbjct: 466 VC---QCSEGF 473



 Score =  161 bits (407), Expect = 2e-39
 Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)

Query: 61  CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
           C  ++  C H  +         C  G  L ++Q  C     D  ++E    ++ C     
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299

Query: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
              C C  G A    G+ C   + V Y C      C     E  + D   L +  +   +
Sbjct: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352

Query: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
             +++     D C      C+ +C +T D   C C  G+ L  D  +C  +N C      
Sbjct: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412

Query: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
           C     C+N   S+ C+    C  GY L  +  +C  +D C    H C  + +C NT  S
Sbjct: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464

Query: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
           F C    QC  GF I + L  C  ++ CL     C   ++C+N + S+ CQ     C  G
Sbjct: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513

Query: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
           + L  +G  C  +D CA     C   H CV+S  SF C+C  GY      + C   + CQ
Sbjct: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571

Query: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
                 C H C N+  SY C C  GFRL+ DG+ C   + C S+   C   C N   SY 
Sbjct: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630

Query: 463 CYCRRGYQLSDVDGVTCEDIDE 484
           C C  G+ L++ DG  C+   E
Sbjct: 631 CKCSEGFVLAE-DGRRCKKCTE 651



 Score =  140 bits (353), Expect = 4e-33
 Identities = 87/266 (32%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C+ +C +  +   C C  GY L  +G +C  V+ C    H C   + C+NT  SF CQ  
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468

Query: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
             C  G+ + ED  +C  +D C    H C  ++ C N   SF C    QC  G +  + G
Sbjct: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520

Query: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
             C  ++ C      C   H+C+++E S+ CQ     C  GY L E+G  C   D C   
Sbjct: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573

Query: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
              C   H CVNS  S+ CEC  G+      + C   + C+      C H C N   SY+
Sbjct: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKS-THHGCEHICVNNGNSYI 630

Query: 424 CSCSVGFRLSVDGRSCEDINECSSSP 449
           C CS GF L+ DGR C+   +C+  P
Sbjct: 631 CKCSEGFVLAEDGRRCK---KCTEGP 653


>gi|194328809 latent transforming growth factor beta binding protein
           3 isoform 1 [Homo sapiens]
          Length = 1303

 Score =  202 bits (513), Expect = 1e-51
 Identities = 142/379 (37%), Positives = 183/379 (48%), Gaps = 48/379 (12%)

Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626

Query: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681

Query: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734

Query: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791

Query: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845

Query: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900

Query: 563 SAATR-CERL-PCHENREC 579
           +     CE +   H  +EC
Sbjct: 901 TQDQHGCEEVEQPHHKKEC 919



 Score =  185 bits (469), Expect = 1e-46
 Identities = 140/416 (33%), Positives = 188/416 (45%), Gaps = 57/416 (13%)

Query: 170 EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
           E ++  LN    G G C     D      C C  GY+       C DVNEC   +  C  
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYS----CHCNPGYRSHPQHRYCVDVNEC--EAEPCGP 627

Query: 230 GES-CINTVGSFRCQRDSSCGTGYEL---TEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
           G   C+NT GS+ C     C  GY L       SC D++EC    H C     C N  G 
Sbjct: 628 GRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFPGH 682

Query: 286 FRCRPKLQCKSGFIQDALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
           ++C     C  G+   A     C DI+EC   S+ CP G  C N  GS+ C      C  
Sbjct: 683 YKC----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIA----CQP 732

Query: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
           GY  ++ G  C DV+ECA    PC  G  C N PGSFRC C  GY      R C+DV+EC
Sbjct: 733 GYR-SQGGGACRDVNECA-EGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789

Query: 404 QRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGS 460
           +   G +C +  C NT GS+ C C  G+ LS D   CEDI+EC   ++    +C N  GS
Sbjct: 790 E--AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847

Query: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
           Y+C C +G++L  V G  C+DIDEC+      +    C N+ GS+ C C   G+    + 
Sbjct: 848 YRCLCPQGHRL--VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQ 904

Query: 521 RNCQDID------ECVTGIH-----------NCSINETCFNIQGGF--RCLAFECP 557
             C++++      EC                N +  E C ++  G+   C  + CP
Sbjct: 905 HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960



 Score =  144 bits (363), Expect = 3e-34
 Identities = 122/397 (30%), Positives = 160/397 (40%), Gaps = 70/397 (17%)

Query: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803

Query: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
             GSF+CQ    C +GY L+ D S C+DIDEC+        D  C NT GS+RC     C 
Sbjct: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINTNGSYRCL----CP 853

Query: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
             G        C DI+EC    + C     C N +GSY C      C  G+   ++   C 
Sbjct: 854  QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV-----CDEGFTPTQDQHGCE 908

Query: 356  DVD------EC-----------------APPAEPC-----GKGHRC------VNSPGSFR 381
            +V+      EC                     E C     G G  C      V S   F 
Sbjct: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968

Query: 382  CECKTGYYFDGISRMCV-------DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLS 433
              C  G  +   + +         D++EC  +   +C   KC NT   Y C C  GF   
Sbjct: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028

Query: 434  VDGRSCEDINEC-SSSPCSQE-CANVYGSYQCYCRRGYQLSDVDGVTCE----DIDECAL 487
             +   C D++EC   S C    C N  G Y+C C    + S            D+DEC  
Sbjct: 1029 GNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD 1088

Query: 488  PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524
            P        RC+N+PGS++C C    +   P+GR+CQ
Sbjct: 1089 PAACR--PGRCVNLPGSYRCEC-RPPWVPGPSGRDCQ 1122



 Score =  117 bits (293), Expect = 4e-26
 Identities = 133/456 (29%), Positives = 166/456 (36%), Gaps = 82/456 (17%)

Query: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915

Query: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975

Query: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031

Query: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
              C+D++ECL  S  C  G  C NT G Y C    P               +DVDEC  P
Sbjct: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDP 1089

Query: 364  AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV-------------DVNECQRYPGRL 410
            A  C  G RCVN PGS+RCEC+  +      R C              DV   QR    +
Sbjct: 1090 AA-CRPG-RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147

Query: 411  C-GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGY 469
            C G      L    C C  G       R C      S  P SQ  +N +         G 
Sbjct: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL-GK 1206

Query: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529
               D D    ED DEC   +G      RC+  PG   C CP  G++L  +   C DIDEC
Sbjct: 1207 PPRDEDSSE-EDSDECRCVSG------RCVPRPGGAVCECPG-GFQLDASRARCVDIDEC 1258

Query: 530  --VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563
              +        +E C N  G FRC+   C   + RS
Sbjct: 1259 RELNQRGLLCKSERCVNTSGSFRCV---CKAGFARS 1291



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 116/472 (24%), Positives = 165/472 (34%), Gaps = 95/472 (20%)

Query: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-CATGISLANEQDRCAT-- 93
            C  GHR+   +K   +   ++     +    C + Q   +  C  G +   +Q  C    
Sbjct: 852  CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE 911

Query: 94   -PHGDNA------------SLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVF 140
             PH                S+ AT V +   CC LG      G  CE      Y   +  
Sbjct: 912  QPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG---WGDHCEIYPCPVYSSAEFH 968

Query: 141  RACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVC 199
              C          D  G  + + I+                G   CK+ +C +T     C
Sbjct: 969  SLCP---------DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC 1019

Query: 200  SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DN 258
             C  G+    + + C DV+EC+  S+ CR G  C NT G +RC    +C    E +    
Sbjct: 1020 YCKQGFYYDGNLLECVDVDECLDESN-CRNGV-CENTRGGYRC----ACTPPAEYSPAQR 1073

Query: 259  SC-----KDIDECESGIHNCLPDFICQNTLGSFRC--RP--------------------- 290
             C      D+DEC+     C P   C N  GS+RC  RP                     
Sbjct: 1074 QCLSPEEMDVDECQDPAA-CRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131

Query: 291  ---KLQCKSGFIQDAL------GNCIDINECLSISA--------PCP---IGHTCINTEG 330
               +  C S   +D +      G  +  ++C             PCP    G  C  ++ 
Sbjct: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1191

Query: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390
                  +      G    +E +   D DEC      C  G RCV  PG   CEC  G+  
Sbjct: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQL 1245

Query: 391  DGISRMCVDVNECQ--RYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439
            D     CVD++EC+     G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 64/314 (20%)

Query: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047

Query: 272  NCLPDFICQNTLGSFRCR--PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTE 329
            N     +C+NT G +RC   P  +      Q      +D++EC   +A C  G  C+N  
Sbjct: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAA-CRPGR-CVNLP 1101

Query: 330  GSYTCQKNVP----NCGRGYHLNE------------------EGTRC--------VDVDE 359
            GSY C+   P      GR   L E                  E   C        +  D+
Sbjct: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161

Query: 360  CA-----------PPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408
            C             P  P G G  C  S         T     G      D +E      
Sbjct: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221

Query: 409  RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-----C-SQECANVYGSYQ 462
            R    +C    G  +C C  GF+L      C DI+EC         C S+ C N  GS++
Sbjct: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281

Query: 463  CYCRRGYQLSDVDG 476
            C C+ G+  S   G
Sbjct: 1282 CVCKAGFARSRPHG 1295



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395

Query: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
                + + C R   P   C H     L   LC CSVG
Sbjct: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382

Query: 511 SSGYRLAPNGRNC 523
             G+ L P+   C
Sbjct: 383 -PGHSLGPSRTQC 394



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 31/103 (30%), Positives = 44/103 (42%), Gaps = 18/103 (17%)

Query: 256  EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-LGNCIDINECLS 314
            ED+S +D DEC      C+P        G   C    +C  GF  DA    C+DI+EC  
Sbjct: 1211 EDSSEEDSDECRCVSGRCVP------RPGGAVC----ECPGGFQLDASRARCVDIDECRE 1260

Query: 315  ISAPCPI--GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            ++    +     C+NT GS+ C      C  G+  +     CV
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCV-----CKAGFARSRPHGACV 1298



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371

Query: 417 NTLGSYLCSCSVGFRLSVDGRSC 439
           N  GSY C C  G  L      C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383

Query: 344 GYHLNEEGTRCV 355
           G+ L    T+C+
Sbjct: 384 GHSLGPSRTQCI 395



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 8/83 (9%)

Query: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385

Query: 561 RRS-AATRCERLPCHENRECSKL 582
               + T+C      E   C +L
Sbjct: 386 SLGPSRTQCIADKPEEKSLCFRL 408



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374

Query: 284 GSFRC 288
           GS+RC
Sbjct: 375 GSYRC 379


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score =  202 bits (513), Expect = 1e-51
 Identities = 142/379 (37%), Positives = 183/379 (48%), Gaps = 48/379 (12%)

Query: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCL 274
           + +EC    + C  GE C+     + C     C  GY    +   C D++ECE+    C 
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCH----CNPGYRSHPQHRYCVDVNECEA--EPCG 626

Query: 275 PDF-ICQNTLGSFRCRPKLQCKSGF---IQDALGNCIDINECLSISAPCPIGHTCINTEG 330
           P   IC NT GS+ C     C  G+   +     +C+D+NEC      C  G  CIN  G
Sbjct: 627 PGRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPG 681

Query: 331 SYTCQKNVPNCGRGYHLNEEGTR-CVDVDECAPPAEPCGKGHRCVNSPGSFRC-ECKTGY 388
            Y C     NC  GY L       C D+DEC  P+  C  G +C N PGSF+C  C+ GY
Sbjct: 682 HYKC-----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIACQPGY 734

Query: 389 YFDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS 447
              G    C DVNEC    G  C    CEN  GS+ C+C+ G+  + DGRSC D++EC +
Sbjct: 735 RSQG-GGACRDVNECAE--GSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA 791

Query: 448 SPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT---GGHICSYRCINIP 502
                   C+N  GS+QC C  GY LS  D   CEDIDEC  P    GG      CIN  
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSR-DRSHCEDIDECDFPAACIGGD-----CINTN 845

Query: 503 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562
           GS++C CP  G+RL   GR CQDIDEC      C  +  C N+QG + C+   C E +  
Sbjct: 846 GSYRCLCP-QGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV---CDEGFTP 900

Query: 563 SAATR-CERL-PCHENREC 579
           +     CE +   H  +EC
Sbjct: 901 TQDQHGCEEVEQPHHKKEC 919



 Score =  185 bits (469), Expect = 1e-46
 Identities = 140/416 (33%), Positives = 188/416 (45%), Gaps = 57/416 (13%)

Query: 170 EQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL 229
           E ++  LN    G G C     D      C C  GY+       C DVNEC   +  C  
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYS----CHCNPGYRSHPQHRYCVDVNEC--EAEPCGP 627

Query: 230 GES-CINTVGSFRCQRDSSCGTGYEL---TEDNSCKDIDECESGIHNCLPDFICQNTLGS 285
           G   C+NT GS+ C     C  GY L       SC D++EC    H C     C N  G 
Sbjct: 628 GRGICMNTGGSYNCH----CNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGFCINFPGH 682

Query: 286 FRCRPKLQCKSGFIQDALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
           ++C     C  G+   A     C DI+EC   S+ CP G  C N  GS+ C      C  
Sbjct: 683 YKC----NCYPGYRLKASRPPVCEDIDECRDPSS-CPDG-KCENKPGSFKCIA----CQP 732

Query: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
           GY  ++ G  C DV+ECA    PC  G  C N PGSFRC C  GY      R C+DV+EC
Sbjct: 733 GYR-SQGGGACRDVNECA-EGSPCSPGW-CENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789

Query: 404 QRYPGRLCGHK-CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGS 460
           +   G +C +  C NT GS+ C C  G+ LS D   CEDI+EC   ++    +C N  GS
Sbjct: 790 E--AGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847

Query: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
           Y+C C +G++L  V G  C+DIDEC+      +    C N+ GS+ C C   G+    + 
Sbjct: 848 YRCLCPQGHRL--VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQ 904

Query: 521 RNCQDID------ECVTGIH-----------NCSINETCFNIQGGF--RCLAFECP 557
             C++++      EC                N +  E C ++  G+   C  + CP
Sbjct: 905 HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP 960



 Score =  154 bits (388), Expect = 3e-37
 Identities = 137/488 (28%), Positives = 182/488 (37%), Gaps = 132/488 (27%)

Query: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            D C  G  C    C +T     C C  GY L  D   CED++EC   + +C +G  CINT
Sbjct: 787  DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA-AC-IGGDCINT 844

Query: 237  VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
             GS+RC     C  G+ L     C+DIDEC      CLP   C+N  GS+ C     C  
Sbjct: 845  NGSYRCL----CPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC----VCDE 896

Query: 297  GFI--QDALGNCIDINE------------------------------CLSISA------- 317
            GF   QD  G C ++ +                              C S+ A       
Sbjct: 897  GFTPTQDQHG-CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955

Query: 318  --PCPIG-----HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
              PCP+      H+       YT   N+ N G   H         D+DEC        K 
Sbjct: 956  IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR--------DIDECMLFGSEICKE 1007

Query: 371  HRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430
             +CVN+   + C CK G+Y+DG    CVDV+EC        G  CENT G Y C+C+   
Sbjct: 1008 GKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA 1066

Query: 431  RLSVDGRSCEDINECSSSP---------------CSQECANVYGSY-QCYCRRG------ 468
              S   R C    E   +P               C+   A    ++  C CR+G      
Sbjct: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126

Query: 469  -----------------------YQLSDV--------DGVTCEDIDECALPTGGHICSYR 497
                                   +  S +        +  + ED DEC   +G      R
Sbjct: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSG------R 1180

Query: 498  CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFE 555
            C+  PG   C CP  G++L  +   C DIDEC  +        +E C N  G FRC+   
Sbjct: 1181 CVPRPGGAVCECP-GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV--- 1236

Query: 556  CPENYRRS 563
            C   + RS
Sbjct: 1237 CKAGFARS 1244



 Score =  119 bits (298), Expect = 9e-27
 Identities = 103/334 (30%), Positives = 133/334 (39%), Gaps = 63/334 (18%)

Query: 178  DRCRGGGPCKQQ-CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
            + C  G PC    C +      C+C  GY    DG SC DV+EC  G   C  G  C NT
Sbjct: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD-VCDNG-ICSNT 803

Query: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
             GSF+CQ    C +GY L+ D S C+DIDEC+        D  C NT GS+RC     C 
Sbjct: 804  PGSFQCQ----CLSGYHLSRDRSHCEDIDECDFPAACIGGD--CINTNGSYRC----LCP 853

Query: 296  SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
             G        C DI+EC    + C     C N +GSY C      C  G+   ++   C 
Sbjct: 854  QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV-----CDEGFTPTQDQHGCE 908

Query: 356  DVD------EC-----------------APPAEPC-----GKGHRC------VNSPGSFR 381
            +V+      EC                     E C     G G  C      V S   F 
Sbjct: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968

Query: 382  CECKTGYYFDGISRMC-------VDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLS 433
              C  G  +   + +         D++EC  +   +C   KC NT   Y C C  GF   
Sbjct: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028

Query: 434  VDGRSCEDINEC-SSSPC-SQECANVYGSYQCYC 465
             +   C D++EC   S C +  C N  G Y+C C
Sbjct: 1029 GNLLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 76/273 (27%), Positives = 105/273 (38%), Gaps = 64/273 (23%)

Query: 216  DVNECIT-GSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDEC--ESGIH 271
            D++EC+  GS  C+ G+ C+NT   + C     C  G+    +   C D+DEC  ES   
Sbjct: 993  DIDECMLFGSEICKEGK-CVNTQPGYECY----CKQGFYYDGNLLECVDVDECLDESNCR 1047

Query: 272  NCLPDFICQNTLGSFRCR---------PKLQCKS---------------------GFIQD 301
            N     +C+NT G +RC           + QC S                     G    
Sbjct: 1048 NG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103

Query: 302  AL-GNCIDINECLSISA--------PCP---IGHTCINTEGSYTCQKNVPNCGRGYHLNE 349
             L G  +  ++C             PCP    G  C  ++       +      G    +
Sbjct: 1104 PLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD 1163

Query: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYP 407
            E +   D DEC      C  G RCV  PG   CEC  G+  D     CVD++EC+     
Sbjct: 1164 EDSSEEDSDECR-----CVSG-RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217

Query: 408  GRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSC 439
            G LC   +C NT GS+ C C  GF  S    +C
Sbjct: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 98/399 (24%), Positives = 128/399 (32%), Gaps = 98/399 (24%)

Query: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVN---- 218
            K  +++E  +DP L   C   G CK    +     VC C  G+    D   CE+V     
Sbjct: 863  KCQDIDECSQDPSL---CLPHGACK----NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915

Query: 219  --ECITGSHS------------------CRLGESCINTVGSFRCQRDSS------CGTGY 252
              EC                        C LG    +    + C   SS      C  G 
Sbjct: 916  KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 975

Query: 253  ELTEDNSC--------KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-L 303
              T+DN+         +DIDEC         +  C NT   + C     CK GF  D  L
Sbjct: 976  GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYEC----YCKQGFYYDGNL 1031

Query: 304  GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVP--------NCGRGYHLNEEGTR-- 353
              C+D++ECL  S  C  G  C NT G Y C    P         C     +     R  
Sbjct: 1032 LECVDVDECLDESN-CRNG-VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD 1089

Query: 354  -------------------CVDVDECA-----------PPAEPCGKGHRCVNSPGSFRCE 383
                                +  D+C             P  P G G  C  S       
Sbjct: 1090 VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSF 1149

Query: 384  CKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN 443
              T     G      D +E      R    +C    G  +C C  GF+L      C DI+
Sbjct: 1150 WDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDID 1209

Query: 444  ECSSSP-----C-SQECANVYGSYQCYCRRGYQLSDVDG 476
            EC         C S+ C N  GS++C C+ G+  S   G
Sbjct: 1210 ECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 340 NCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398
           +C +GY  LN   T C D++ECA P   C  G  C+N+PGS+RC C  G+        C+
Sbjct: 340 DCPQGYKRLNS--THCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLGPSRTQCI 395

Query: 399 -----DVNECQRY--PGRLCGHKCENTLGSYLCSCSVG 429
                + + C R   P   C H     L   LC CSVG
Sbjct: 396 ADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 7/73 (9%)

Query: 452 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCP 510
           Q+   V G     C +GY+   ++   C+DI+ECA+P    +C +  C+N PGS++C CP
Sbjct: 328 QKPGPVRGEVGADCPQGYKR--LNSTHCQDINECAMPG---VCRHGDCLNNPGSYRCVCP 382

Query: 511 SSGYRLAPNGRNC 523
             G+ L P+   C
Sbjct: 383 -PGHSLGPSRTQC 394



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 31/103 (30%), Positives = 44/103 (42%), Gaps = 18/103 (17%)

Query: 256  EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDA-LGNCIDINECLS 314
            ED+S +D DEC      C+P        G   C    +C  GF  DA    C+DI+EC  
Sbjct: 1164 EDSSEEDSDECRCVSGRCVP------RPGGAVC----ECPGGFQLDASRARCVDIDECRE 1213

Query: 315  ISAPCPI--GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
            ++    +     C+NT GS+ C      C  G+  +     CV
Sbjct: 1214 LNQRGLLCKSERCVNTSGSFRCV-----CKAGFARSRPHGACV 1251



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 31/83 (37%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 369 KGHRC-------VNSPGSFRCE----CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCE 416
           K H+C       V  PG  R E    C  GY     S  C D+NEC   PG +C H  C 
Sbjct: 315 KCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN-STHCQDINECAM-PG-VCRHGDCL 371

Query: 417 NTLGSYLCSCSVGFRLSVDGRSC 439
           N  GSY C C  G  L      C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 3/54 (5%)

Query: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
           G     C  G++  ++   C+DINEC+     +  +C N  GSY+C C  G+ L
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 7/72 (9%)

Query: 284 GSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
           G  R      C  G+ +    +C DINEC ++   C  G  C+N  GSY C      C  
Sbjct: 331 GPVRGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHG-DCLNNPGSYRCV-----CPP 383

Query: 344 GYHLNEEGTRCV 355
           G+ L    T+C+
Sbjct: 384 GHSLGPSRTQCI 395



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 8/83 (9%)

Query: 501 IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
           + G     CP    RL  N  +CQDI+EC   +     +  C N  G +RC+   CP  +
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINEC--AMPGVCRHGDCLNNPGSYRCV---CPPGH 385

Query: 561 RRS-AATRCERLPCHENRECSKL 582
               + T+C      E   C +L
Sbjct: 386 SLGPSRTQCIADKPEEKSLCFRL 408



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)

Query: 225 HSC-RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283
           H C +L  + +   G  R +  + C  GY+      C+DI+EC   +        C N  
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVCRHGDCLNNP 374

Query: 284 GSFRC 288
           GS+RC
Sbjct: 375 GSYRC 379


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  197 bits (500), Expect = 3e-50
 Identities = 130/385 (33%), Positives = 187/385 (48%), Gaps = 41/385 (10%)

Query: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
           C   C +      C+C+ G+ L  DG +C DV+EC  G+  C+  +SC+N +GS+ C   
Sbjct: 82  CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137

Query: 246 SSCGTGYELTEDNSCKDIDECESGIHNCLPD-----FICQNT-LGSFRCRPKLQCKSGFI 299
             C  G+ L+ DN    I   E G+ NC+        IC+ T  G   C    +C+ GF 
Sbjct: 138 --CREGFFLS-DNQHTCIQRPEEGM-NCMNKNHGCAHICRETPKGGIAC----ECRPGF- 188

Query: 300 QDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVD 358
            +   N  D    C   +  C   HTC +TE    C      C   + L+ +G  C++  
Sbjct: 189 -ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET- 239

Query: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT 418
            CA     C    +C ++     C C  G+      + C D++EC+   G  C H C NT
Sbjct: 240 -CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRNT 295

Query: 419 LGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDGV 477
           +GS+ CSC  G++L ++ R+C+DI+ECS    C   C N  GS+QC C RGY L    G+
Sbjct: 296 VGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---GI 352

Query: 478 T-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC 536
           T C D+DEC++  GG  C + CIN PGS+QC+CP+   RL  NG++C +  +C  G    
Sbjct: 353 THCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPGA 409

Query: 537 SINETCFNIQGGFRCLAFECPENYR 561
           S      N  G     A  CP   R
Sbjct: 410 SKAMLSCNRSGKKDTCALTCPSRAR 434



 Score =  191 bits (485), Expect = 2e-48
 Identities = 122/363 (33%), Positives = 171/363 (47%), Gaps = 40/363 (11%)

Query: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
           + +DV+EC+ G+ +C +   C NT  S++C     C +GY   +   CKD+DECE   + 
Sbjct: 26  AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80

Query: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
            C+ D  C N  G++RC     C  GF     G NC+D++EC   +  C    +C+N  G
Sbjct: 81  GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132

Query: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
           SY C     +C  G+ L++    C+   E    C      C   H C  +P G   CEC+
Sbjct: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185

Query: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
            G+      R C        Y    C H C++T     C C + F L  DG++C +    
Sbjct: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242

Query: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
           ++  C  +C +      C C  G+ L   D  TC+DIDEC L  GG  C + C N  GSF
Sbjct: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299

Query: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565
           +CSC   GY+L  N RNCQDIDEC     + + +  C N  G F+CL   C   Y     
Sbjct: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL---CHRGYLLYGI 352

Query: 566 TRC 568
           T C
Sbjct: 353 THC 355



 Score =  112 bits (279), Expect = 1e-24
 Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)

Query: 37  CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
           C DG  +A    +C      +  EC      C  S +      E HC  G  L++ Q  C
Sbjct: 97  CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151

Query: 92  ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
                +  +        C H C   R     G +CE     G++  +  R C +    T 
Sbjct: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201

Query: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
           +   GG Q T    E           V        +       G C  +C D    V C+
Sbjct: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261

Query: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
           C VG+ L  D  +C+D++EC   +  C     C NTVGSF C    SC  GY+ L  + +
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315

Query: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
           C+DIDEC S    C  D IC NT GSF+C     C  G++   + +C D++EC      C
Sbjct: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368

Query: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
             G  CINT GSY C      C  G   L+  G  C +  +C
Sbjct: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
           R A   +  QD+DECV G  NC I+  C N    ++C+   C   Y
Sbjct: 19  RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGY 61


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,734,213
Number of Sequences: 37866
Number of extensions: 1758978
Number of successful extensions: 11058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 174
Number of HSP's that attempted gapping in prelim test: 3576
Number of HSP's gapped (non-prelim): 1850
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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