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Search of human proteins with 34485720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34485720 echinoderm microtubule associated protein like 5
[Homo sapiens]
(1977 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 4083 0.0
gi|223005862 echinoderm microtubule associated protein like 6 [H... 3159 0.0
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 389 e-107
gi|56790932 echinoderm microtubule associated protein like 1 iso... 382 e-105
gi|56790930 echinoderm microtubule associated protein like 1 iso... 382 e-105
gi|223029510 echinoderm microtubule associated protein like 4 is... 365 e-100
gi|19923497 echinoderm microtubule associated protein like 4 iso... 365 e-100
gi|110227615 echinoderm microtubule associated protein like 3 [H... 323 1e-87
gi|94400919 WD repeat domain 90 [Homo sapiens] 150 9e-36
gi|31377846 WD repeat domain 52 [Homo sapiens] 134 9e-31
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 82 4e-15
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 80 2e-14
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 80 3e-14
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 77 2e-13
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 75 8e-13
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 75 8e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 70 2e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 70 3e-11
gi|145279222 WD repeat domain 66 [Homo sapiens] 67 1e-10
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 65 9e-10
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 62 4e-09
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 62 4e-09
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 62 4e-09
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 60 2e-08
gi|19913367 transducin beta-like 1Y [Homo sapiens] 60 2e-08
gi|19913365 transducin beta-like 1Y [Homo sapiens] 60 2e-08
gi|15150805 transducin beta-like 1Y [Homo sapiens] 60 2e-08
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 59 5e-08
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 59 5e-08
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 59 5e-08
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 4083 bits (10590), Expect = 0.0
Identities = 1977/1977 (100%), Positives = 1977/1977 (100%)
Query: 1 MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH 60
MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH
Sbjct: 1 MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH 60
Query: 61 SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR 120
SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR
Sbjct: 61 SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR 120
Query: 121 LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC 180
LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC
Sbjct: 121 LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC 180
Query: 181 GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI 240
GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI
Sbjct: 181 GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI 240
Query: 241 FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT 300
FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT
Sbjct: 241 FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT 300
Query: 301 QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI 360
QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI
Sbjct: 301 QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI 360
Query: 361 ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG 420
ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG
Sbjct: 361 ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG 420
Query: 421 TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM 480
TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM
Sbjct: 421 TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM 480
Query: 481 PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG 540
PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG
Sbjct: 481 PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG 540
Query: 541 IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK 600
IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK
Sbjct: 541 IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK 600
Query: 601 DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK 660
DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK
Sbjct: 601 DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK 660
Query: 661 QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ 720
QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ
Sbjct: 661 QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ 720
Query: 721 RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF 780
RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF
Sbjct: 721 RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF 780
Query: 781 SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM 840
SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM
Sbjct: 781 SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM 840
Query: 841 KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK 900
KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK
Sbjct: 841 KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK 900
Query: 901 AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS 960
AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS
Sbjct: 901 AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS 960
Query: 961 IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK 1020
IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK
Sbjct: 961 IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK 1020
Query: 1021 TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH 1080
TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH
Sbjct: 1021 TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH 1080
Query: 1081 RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL 1140
RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL
Sbjct: 1081 RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL 1140
Query: 1141 QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC 1200
QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC
Sbjct: 1141 QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC 1200
Query: 1201 LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD 1260
LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD
Sbjct: 1201 LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD 1260
Query: 1261 MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG 1320
MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG
Sbjct: 1261 MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG 1320
Query: 1321 IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYR 1380
IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYR
Sbjct: 1321 IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYR 1380
Query: 1381 GRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIV 1440
GRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIV
Sbjct: 1381 GRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIV 1440
Query: 1441 ATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPE 1500
ATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPE
Sbjct: 1441 ATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPE 1500
Query: 1501 HTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKG 1560
HTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKG
Sbjct: 1501 HTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKG 1560
Query: 1561 LLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTL 1620
LLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTL
Sbjct: 1561 LLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTL 1620
Query: 1621 RDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRN 1680
RDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRN
Sbjct: 1621 RDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRN 1680
Query: 1681 AEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKV 1740
AEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKV
Sbjct: 1681 AEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKV 1740
Query: 1741 NLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYL 1800
NLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYL
Sbjct: 1741 NLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYL 1800
Query: 1801 AVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVP 1860
AVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVP
Sbjct: 1801 AVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVP 1860
Query: 1861 SGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGM 1920
SGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGM
Sbjct: 1861 SGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGM 1920
Query: 1921 VKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH 1977
VKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH
Sbjct: 1921 VKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH 1977
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 3159 bits (8191), Expect = 0.0
Identities = 1466/1973 (74%), Positives = 1713/1973 (86%), Gaps = 15/1973 (0%)
Query: 1 MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGH 60
MA R+AP C LRLEWVYGYRGHQCRNNLYYTA KE+VYFVAGVGVVY+ REH QKF+ GH
Sbjct: 1 MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH 60
Query: 61 SDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQR 120
+DDIISLALHP++ LVATGQVGKEPYICIWDSY VQT+S+LKDVHTHG+ACLAFD DGQR
Sbjct: 61 NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR 120
Query: 121 LVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC 180
L SVGLD+KN VC+WDW++GK+L+ A GH+DRIFDISWD YQPN++VSCGVKHIKFW+LC
Sbjct: 121 LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC 180
Query: 181 GNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGI 240
GNALT KRG+FGKTGDLQTILCLACA++++TYSGALNGDIYVWKG+NL+RTIQGAH+AGI
Sbjct: 181 GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI 240
Query: 241 FSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGT 300
FSM ACEEGFATGGRDGCIRLWD FKPIT IDLRET+QGYKGLS+RSVCW+ D +L GT
Sbjct: 241 FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT 300
Query: 301 QDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI 360
QDSEIFE++V+ER+KP LI+QGHCEGELWALA+HP KPLAVTGSDDRSVR+WSL DHALI
Sbjct: 301 QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI 360
Query: 361 ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG 420
ARCNMEE +R A + DG LALGMKDGSF VLRVRDMTEVVHIKDRKE IHE+K+SPDG
Sbjct: 361 ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG 420
Query: 421 TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRM 480
+YLAVG ND VD+Y VAQRYKK+GEC SLSFITH+DWS DS+YLQTNDG G+RLFYRM
Sbjct: 421 SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM 480
Query: 481 PGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYG 540
P GK +TS EEIKG+ WASWTCV G EV+GIWPKY+++ DINSVD NY VLV+ DD+G
Sbjct: 481 PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG 540
Query: 541 IIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLK 600
++KLF++PCL++GAKFRKY+GHSAHVTNVRWSHD+QWV+S GGADHSVFQW+FIPE
Sbjct: 541 LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN 600
Query: 601 DAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEK 660
+ APQE ADS+S+ESDSDLSDVPELDS+IEQE Q+ Y RQVYKEDLPQLK+Q KEK
Sbjct: 601 GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK 660
Query: 661 QKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQ 720
+ +RE+AP +S++L F+HGYRGYDCR+NLFYTQ GE+VYH+AAV V+YNRQQ++Q
Sbjct: 661 NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ 720
Query: 721 RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF 780
R YLGHDDDIL LTIHP+KDYVATGQVGRD +IH+WDT+T+K LS+LKG HQ GV A+DF
Sbjct: 721 RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF 780
Query: 781 SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHM 840
SADGK L SVG+DD H++V WDWKKGEK++ RG KDKIFVVK NP+ DKL+T GIKH+
Sbjct: 781 SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI 840
Query: 841 KFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVK 900
KFW++AGGG ++G G++GK +TMMC YG E++ FSG +TGD+ IW+DI L+KTVK
Sbjct: 841 KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK 900
Query: 901 AHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPS 960
AHDGPVF+M+AL+KGFVTGGKDGIV LWDD FERCLKTYAIKR+AL+ SKGLLLEDNPS
Sbjct: 901 AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS 960
Query: 961 IRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDK 1020
IRAI+LGHGHILVGTKNGEILE+DKSGP+TLLVQGHMEGEVWGLA HP LPICATVSDDK
Sbjct: 961 IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK 1020
Query: 1021 TLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHH 1080
TLRIW+LS H MLAVRKLKKGGRCC FSPDGKALAVGLNDGSFL+ NADT+ED+VSFHH
Sbjct: 1021 TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH 1080
Query: 1081 RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLL 1140
RK+MISDI+FS +GKYLAVASHD+F+DIYNV++SKRVGICKGA+SYITHIDWD RGKLL
Sbjct: 1081 RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
Query: 1141 QVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASC 1200
QVN+GA+EQLFFEAPRGK+ I E+EKI W +WT VLG CEGIWP ++TDV A+
Sbjct: 1141 QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS 1200
Query: 1201 LTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTD 1260
LT D +LATGDD GFVKLF YP KG+ +FK+YV HS HVTNVRW ++DS+L+T+GG D
Sbjct: 1201 LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD 1260
Query: 1261 MSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG 1320
+LM+WT E G +E + DSEESD D EEDGGYDSDV RE I YT + + +IR M G
Sbjct: 1261 TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG 1320
Query: 1321 IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYR 1380
KPH Q KE S++E RPPVSRA PQPEKLQ NN+ KKK+ +E+L L+ +FGYR
Sbjct: 1321 TKPHQQLKEVSVEE--------RPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYR 1372
Query: 1381 GRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIV 1440
G DCRNN+HYLNDG DII+HTA+ GI+ N++TGSQSFY EH DDILCLTVNQHPK+ N+V
Sbjct: 1373 GFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVV 1432
Query: 1441 ATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPE 1500
AT Q+G T PSIHIWDAM K TLS+LRC+HSKGV ++FSATGKLL+SVG+DPE
Sbjct: 1433 ATSQIG-------TTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPE 1485
Query: 1501 HTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKG 1560
HTIT+WRWQEGAK+ASR GH +RIFV EFRPDSDTQFVSVGVKH+KFWTLAG ALL KKG
Sbjct: 1486 HTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKG 1545
Query: 1561 LLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTL 1620
++ +L A+MQTML++AFGANNLTFTG I+GDV VWKDH L R+VA+AH GPVF MYTTL
Sbjct: 1546 VIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTL 1605
Query: 1621 RDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRN 1680
RDGLIVTGGKERP+KEGGAVKLWDQE++RCRAF+LETGQ +CVRSVCRGKGKILVGT++
Sbjct: 1606 RDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKD 1665
Query: 1681 AEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKV 1740
EIIEVGEKNAA NIL++GH++G IWGLATHPS+D F+SA+ DGT R+WD+ADKK+LNKV
Sbjct: 1666 GEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV 1725
Query: 1741 NLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYL 1800
+LGHAAR YSP+G+MVAIGMKNGEF+ILLV+SLK+WGKKRDR+ AI DIR SPD+R+L
Sbjct: 1726 SLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1785
Query: 1801 AVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVP 1860
AVGSSE++VDFYDLT G LNRI YCKDIPSFVIQMDFSAD Y+QVS+G YKR V+EVP
Sbjct: 1786 AVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVP 1845
Query: 1861 SGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGM 1920
GK + + I++ITWA+WTS+LGDEV+GIW R+A+KADVNCACV+H+G+++VTGDDFG+
Sbjct: 1846 LGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGL 1905
Query: 1921 VKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
VKLFDFPC EKFAKHKR+ GHS HVTNIRF+ D++VVS GGDDCS+FVW+C+
Sbjct: 1906 VKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 389 bits (1000), Expect = e-107
Identities = 233/607 (38%), Positives = 336/607 (55%), Gaps = 27/607 (4%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
PSC L+LEWVYGYRG CR NLY EIVYFVA V V+YS E RQ+ Y GH+DDI
Sbjct: 51 PSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKC 110
Query: 67 LALHPERVLVATGQVG---KE-----PYICIWDSYTVQTISVLK-DVHTHGIACLAFDLD 117
LA+HP+ V +ATGQV KE P++ IWDS ++ T+ VL V + C+ F
Sbjct: 111 LAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
Query: 118 --GQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
G L +V + + + VWDW + + + + ++ P L++CG HI
Sbjct: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
Query: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLI-RTIQ 233
FW+L G +L+ ++G+F K + +LC+ +G G++YVW KG N I + +
Sbjct: 231 FWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
Query: 234 GAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVC- 290
GAH G+F + A +G + GGRD + LW + + +++ E D G VR+V
Sbjct: 291 GAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPE-DFG----PVRTVAE 345
Query: 291 WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350
GD + VGT + I + V L++QGH E ELW LA HP++ VT D+ V
Sbjct: 346 GHGDTLYVGTTRNSILQGSVHTGFS--LLVQGHVE-ELWGLATHPSRAQFVTCGQDKLVH 402
Query: 351 IWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEA 410
+WS H + +E+P R A + G LA+G G + +L V D E
Sbjct: 403 LWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQ 462
Query: 411 IHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKV---GECLGSLSFITHLDWSSDSRYLQ 467
I + +SPDG YLAVG +D+ V +Y V Q +KV G+C G SFITHLDW+ DS
Sbjct: 463 ISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFV 522
Query: 468 TNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGN 527
TN G+ + L++ K++TS + ++ + WA+ TCV G V GIW + +D DIN+V +
Sbjct: 523 TNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARS 582
Query: 528 YIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHS 587
+ G++L +ADD+G + LF YPC + A KY GHS+HVTNV + D ++ GG D S
Sbjct: 583 HDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTS 642
Query: 588 VFQWKFI 594
V QW+ +
Sbjct: 643 VLQWRVV 649
Score = 344 bits (883), Expect = 4e-94
Identities = 224/620 (36%), Positives = 315/620 (50%), Gaps = 42/620 (6%)
Query: 669 RERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDD 728
R P ++L +V+GYRG DCR+NL+ GEIVY VA+V V+Y+ ++ QR YLGH+D
Sbjct: 47 RSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHND 106
Query: 729 DILCLTIHPLKDYVATGQVG--------RDPSIHIWDTETIKPLSIL-KGHHQYGVSAVD 779
DI CL IHP +ATGQV P + IWD+ ++ L +L G V V
Sbjct: 107 DIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVG 166
Query: 780 FSAD--GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI 837
FS G L +V + H + +WDW K K+ + S + + V +P P LIT G
Sbjct: 167 FSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGK 226
Query: 838 KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW---RDIF 894
H+ FW GG L R+G K ++C + ++ +G S G++ +W +
Sbjct: 227 SHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRI 285
Query: 895 LVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTYAIKRAALAPGSKG 952
+ AHDG VF + AL G + GG+D V LW + + +
Sbjct: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVE------------- 332
Query: 953 LLLEDNPSIRAISLGHGHIL-VGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLP 1011
+ ED +R ++ GHG L VGT IL+ +LLVQGH+E E+WGLATHP
Sbjct: 333 -VPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVE-ELWGLATHPSRA 390
Query: 1012 ICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADT 1071
T DK + +W S SH L R ++ R F P G LAVG G +L+ + +T
Sbjct: 391 QFVTCGQDKLVHLWS-SDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTET 449
Query: 1072 LEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNV----MSSKRVGICKGATS 1126
DLV+ H + IS + FSP G YLAV SHD+ + +Y V R+G C G +S
Sbjct: 450 -HDLVAIHTDGNEQISVVSFSP-DGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSS 507
Query: 1127 YITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGI 1186
+ITH+DW N+G E L+++ P KQ + V + WA+ T VLG GI
Sbjct: 508 FITHLDWAQDSSCFVTNSGDYEILYWD-PATCKQITSADAVRNMEWATATCVLGFGVFGI 566
Query: 1187 WPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRW 1246
W + TD+ A + D +LA+ DD G V LF YP +Y HS+HVTNV +
Sbjct: 567 WSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAF 626
Query: 1247 TYDDSMLVTLGGTDMSLMVW 1266
+DDSM +T GG D S++ W
Sbjct: 627 LWDDSMALTTGGKDTSVLQW 646
Score = 337 bits (864), Expect = 7e-92
Identities = 212/612 (34%), Positives = 320/612 (52%), Gaps = 26/612 (4%)
Query: 1371 LVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTV 1430
L LE ++GYRGRDCR N++ L G+ I+Y ASV +L++V Q Y HNDDI CL +
Sbjct: 55 LKLEWVYGYRGRDCRANLYLLPTGE-IVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
Query: 1431 NQHPKFINIVATGQV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVSFSAT 1488
HP + I ATGQV G + + P + IWD+++ TL +L + VC V FS +
Sbjct: 114 --HPDMVTI-ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
Query: 1489 --GKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVK 1546
G LL +V +H +++W W + K+ N+ + VA F P T ++ G H+
Sbjct: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
Query: 1547 FWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKD--HILCRI 1604
FWTL G +L ++GL E + +L + F TG G++ VW + + +
Sbjct: 231 FWTLEGGSLSKRQGLFEKHEKPKY--VLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQA 288
Query: 1605 VARAHNGPVFAMYTTLRDGLIVTGG-KERPSKEGGAVKLWDQELRRCRAFRLETGQATDC 1663
V AH+G VF + LRDG +V+GG ++R V LW + + + +E +
Sbjct: 289 VLGAHDGGVFGL-CALRDGTLVSGGGRDR------RVVLWGSDYSKLQ--EVEVPEDFGP 339
Query: 1664 VRSVCRGKGKIL-VGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAE 1722
VR+V G G L VGT I++ G + ++LV GHV+ +WGLATHPSR F++ +
Sbjct: 340 VRTVAEGHGDTLYVGTTRNSILQ-GSVHTGFSLLVQGHVE-ELWGLATHPSRAQFVTCGQ 397
Query: 1723 DGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKR 1782
D V LW + L + AR+ + P G ++A+G G +++L + +
Sbjct: 398 DKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHT 457
Query: 1783 DRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPT-LNRISYCKDIPSFVIQMDFSAD 1841
D I + FSPD YLAVGS +N V Y + G ++R+ C SF+ +D++ D
Sbjct: 458 DGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQD 517
Query: 1842 SSYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVN 1901
SS +SG Y+ ++ + K + A+ + WAT T +LG V GIWS A+ D+N
Sbjct: 518 SSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDIN 577
Query: 1902 CACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAG 1961
SH G L + DDFG V LF +PC + A ++ GHS HVTN+ F D ++ G
Sbjct: 578 AVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTG 637
Query: 1962 GDDCSLFVWKCV 1973
G D S+ W+ V
Sbjct: 638 GKDTSVLQWRVV 649
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 382 bits (982), Expect = e-105
Identities = 220/607 (36%), Positives = 343/607 (56%), Gaps = 27/607 (4%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
P+ L+LEWVYGYRG CRNNLY E VYF+A V V+Y+ E Q+ Y GH+DD+
Sbjct: 236 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 295
Query: 67 LALHPERVLVATGQV------GKE--PYICIWDSYTVQTISVLK-DVHTHGIACLAFDLD 117
LA+HP+R+ +ATGQV GK+ P++ IWDS T+ T+ V+ + C+AF
Sbjct: 296 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 355
Query: 118 --GQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
G L +V + + + VWDW++ + L+ + +F + N +V+CG H+
Sbjct: 356 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 415
Query: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLIR-TIQ 233
FW+L G++L K+G+F K + +LC+ + + T +G +G+I VW KG N I +Q
Sbjct: 416 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 475
Query: 234 GAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVC- 290
GAH GIF++ +G + GG+D + W ++ LR+T+ + +R+V
Sbjct: 476 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 530
Query: 291 WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350
+GD IL+GT + + + + P I QGH + ELW LA+H +K +T D+
Sbjct: 531 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 587
Query: 351 IWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEA 410
+W V H + +E+P + + + G +A+G G + V V D E
Sbjct: 588 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 647
Query: 411 IHELKYSPDGTYLAVGCNDSSVDIYGVA---QRYKKVGECLGSLSFITHLDWSSDSRYLQ 467
+ ++YSPDG +LA+G +D+ + IYGV+ ++Y +VG+C G SFITHLDWS +S++L
Sbjct: 648 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 707
Query: 468 TNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGN 527
+N G+ + L++ K+V S E + + WA++TC G V G+WP+ SD DIN+V
Sbjct: 708 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 767
Query: 528 YIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHS 587
+ ++L T DD+G + LF YPC + A Y GHS+HVTNV + + +IS GG D S
Sbjct: 768 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 827
Query: 588 VFQWKFI 594
+ QW+ I
Sbjct: 828 IMQWRVI 834
Score = 341 bits (874), Expect = 5e-93
Identities = 221/659 (33%), Positives = 336/659 (50%), Gaps = 32/659 (4%)
Query: 1328 KEPSIDERQGVV----RGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRD 1383
KEP +G V RG PV+ P+ + + K + P + L LE ++GYRGRD
Sbjct: 195 KEPVFSAEEGYVKMFLRGR--PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 252
Query: 1384 CRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATG 1443
CRNN++ L G+ + Y ASV +L+NV Q Y HNDD+ CL V HP I I ATG
Sbjct: 253 CRNNLYLLPTGETV-YFIASVVVLYNVEEQLQRHYAGHNDDVKCLAV--HPDRITI-ATG 308
Query: 1444 QV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVSFSAT--GKLLLSVGLDP 1499
QV G S D P + IWD++ TL ++ + + V ++FS + G L +V
Sbjct: 309 QVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSN 368
Query: 1500 EHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKK 1559
+H +++W WQ+ K+A N+ +F A+F P V+ G H+ FWTL G +L K+
Sbjct: 369 DHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQ 428
Query: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKD--HILCRIVARAHNGPVFAMY 1617
GL E + +L + F N T TG SG++ VW + + V AH G +FA+
Sbjct: 429 GLFEKQEKPKF--VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL- 485
Query: 1618 TTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGK-ILV 1676
LRDG +V+GG K+ + W ++ R + E + +R+V GKG IL+
Sbjct: 486 CMLRDGTLVSGG----GKDRKLIS-WSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVILI 538
Query: 1677 GTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKM 1736
GT +++ G + + GH D +WGLA H S+ FL+ D LWD +
Sbjct: 539 GTTRNFVLQ-GTLSGDFTPITQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHRP 596
Query: 1737 LNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPD 1796
+ + A++ + P G +VA+G G + + + + D + +R+SPD
Sbjct: 597 VWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPD 656
Query: 1797 SRYLAVGSSENSVDFYDLT-LGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRH 1855
+LA+GS +N + Y ++ G R+ C SF+ +D+S +S +L +SG Y+
Sbjct: 657 GNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEI- 715
Query: 1856 VYEVPSG-KHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVT 1914
+Y VPS K ++ I WAT+T LG V G+W ++ D+N C +H L T
Sbjct: 716 LYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLST 775
Query: 1915 GDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
GDDFG V LF +PC + A + GHS HVTN+ F D H++S GG D S+ W+ +
Sbjct: 776 GDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834
Score = 335 bits (859), Expect = 3e-91
Identities = 207/633 (32%), Positives = 326/633 (51%), Gaps = 46/633 (7%)
Query: 658 KEKQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQ 717
K++ S + + + P ++L +V+GYRG DCR+NL+ GE VY +A+V V+YN ++
Sbjct: 221 KDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEE 280
Query: 718 NTQRFYLGHDDDILCLTIHPLKDYVATGQVG--------RDPSIHIWDTETIKPLSILK- 768
QR Y GH+DD+ CL +HP + +ATGQV P + IWD+ T+ L ++
Sbjct: 281 QLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGI 340
Query: 769 GHHQYGVSAVDFSAD--GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNP 826
G V+ + FS G L +V + H + +WDW+K EKL+ + S + +F +P
Sbjct: 341 GFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHP 400
Query: 827 YVPDKLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGD 886
+ ++T G H+ FW G L ++G K ++C + + +G S+G+
Sbjct: 401 TDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGD-TITGDSSGN 459
Query: 887 VCIW-----RDIFLVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTY 939
+ +W R + V+ AH+G +F++ L G + GGKD + W ++++ KT
Sbjct: 460 ILVWGKGTNRISYAVQ--GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 517
Query: 940 AIKRAALAPGSKGLLLEDNPSIRAISLGHGH-ILVGTKNGEILEVDKSGPITLLVQGHME 998
+ E IR ++ G G IL+GT +L+ SG T + QGH +
Sbjct: 518 --------------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD 563
Query: 999 GEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVG 1058
E+WGLA H T DK +WD + H + + ++ + F P G +AVG
Sbjct: 564 -ELWGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVG 621
Query: 1059 LNDGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS-- 1115
G + + + +T +DLV+ H + +S +R+SP G +LA+ SHD+ I IY V +
Sbjct: 622 TLTGRWFVFDTET-KDLVTVHTDGNEQLSVMRYSP-DGNFLAIGSHDNCIYIYGVSDNGR 679
Query: 1116 --KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWA 1173
RVG C G +S+ITH+DW + + L N+G E L++ P KQ + I WA
Sbjct: 680 KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWA 738
Query: 1174 SWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKR 1233
++T LG G+WP + TD+ A C +K +L+TGDD G V LF YP
Sbjct: 739 TYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHI 798
Query: 1234 YVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
Y HS+HVTNV + +DS L++ GG D S+M W
Sbjct: 799 YGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQW 831
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 382 bits (982), Expect = e-105
Identities = 220/607 (36%), Positives = 343/607 (56%), Gaps = 27/607 (4%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
P+ L+LEWVYGYRG CRNNLY E VYF+A V V+Y+ E Q+ Y GH+DD+
Sbjct: 217 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 276
Query: 67 LALHPERVLVATGQV------GKE--PYICIWDSYTVQTISVLK-DVHTHGIACLAFDLD 117
LA+HP+R+ +ATGQV GK+ P++ IWDS T+ T+ V+ + C+AF
Sbjct: 277 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 336
Query: 118 --GQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
G L +V + + + VWDW++ + L+ + +F + N +V+CG H+
Sbjct: 337 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 396
Query: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLIR-TIQ 233
FW+L G++L K+G+F K + +LC+ + + T +G +G+I VW KG N I +Q
Sbjct: 397 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 456
Query: 234 GAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVC- 290
GAH GIF++ +G + GG+D + W ++ LR+T+ + +R+V
Sbjct: 457 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 511
Query: 291 WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350
+GD IL+GT + + + + P I QGH + ELW LA+H +K +T D+
Sbjct: 512 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 568
Query: 351 IWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEA 410
+W V H + +E+P + + + G +A+G G + V V D E
Sbjct: 569 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 628
Query: 411 IHELKYSPDGTYLAVGCNDSSVDIYGVA---QRYKKVGECLGSLSFITHLDWSSDSRYLQ 467
+ ++YSPDG +LA+G +D+ + IYGV+ ++Y +VG+C G SFITHLDWS +S++L
Sbjct: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
Query: 468 TNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGN 527
+N G+ + L++ K+V S E + + WA++TC G V G+WP+ SD DIN+V
Sbjct: 689 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 748
Query: 528 YIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHS 587
+ ++L T DD+G + LF YPC + A Y GHS+HVTNV + + +IS GG D S
Sbjct: 749 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 808
Query: 588 VFQWKFI 594
+ QW+ I
Sbjct: 809 IMQWRVI 815
Score = 341 bits (874), Expect = 5e-93
Identities = 221/659 (33%), Positives = 336/659 (50%), Gaps = 32/659 (4%)
Query: 1328 KEPSIDERQGVV----RGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRD 1383
KEP +G V RG PV+ P+ + + K + P + L LE ++GYRGRD
Sbjct: 176 KEPVFSAEEGYVKMFLRGR--PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 233
Query: 1384 CRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATG 1443
CRNN++ L G+ + Y ASV +L+NV Q Y HNDD+ CL V HP I I ATG
Sbjct: 234 CRNNLYLLPTGETV-YFIASVVVLYNVEEQLQRHYAGHNDDVKCLAV--HPDRITI-ATG 289
Query: 1444 QV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVSFSAT--GKLLLSVGLDP 1499
QV G S D P + IWD++ TL ++ + + V ++FS + G L +V
Sbjct: 290 QVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSN 349
Query: 1500 EHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKK 1559
+H +++W WQ+ K+A N+ +F A+F P V+ G H+ FWTL G +L K+
Sbjct: 350 DHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQ 409
Query: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKD--HILCRIVARAHNGPVFAMY 1617
GL E + +L + F N T TG SG++ VW + + V AH G +FA+
Sbjct: 410 GLFEKQEKPKF--VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL- 466
Query: 1618 TTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGK-ILV 1676
LRDG +V+GG K+ + W ++ R + E + +R+V GKG IL+
Sbjct: 467 CMLRDGTLVSGG----GKDRKLIS-WSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVILI 519
Query: 1677 GTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKM 1736
GT +++ G + + GH D +WGLA H S+ FL+ D LWD +
Sbjct: 520 GTTRNFVLQ-GTLSGDFTPITQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHRP 577
Query: 1737 LNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPD 1796
+ + A++ + P G +VA+G G + + + + D + +R+SPD
Sbjct: 578 VWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPD 637
Query: 1797 SRYLAVGSSENSVDFYDLT-LGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRH 1855
+LA+GS +N + Y ++ G R+ C SF+ +D+S +S +L +SG Y+
Sbjct: 638 GNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEI- 696
Query: 1856 VYEVPSG-KHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVT 1914
+Y VPS K ++ I WAT+T LG V G+W ++ D+N C +H L T
Sbjct: 697 LYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLST 756
Query: 1915 GDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
GDDFG V LF +PC + A + GHS HVTN+ F D H++S GG D S+ W+ +
Sbjct: 757 GDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
Score = 335 bits (859), Expect = 3e-91
Identities = 207/633 (32%), Positives = 326/633 (51%), Gaps = 46/633 (7%)
Query: 658 KEKQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQ 717
K++ S + + + P ++L +V+GYRG DCR+NL+ GE VY +A+V V+YN ++
Sbjct: 202 KDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEE 261
Query: 718 NTQRFYLGHDDDILCLTIHPLKDYVATGQVG--------RDPSIHIWDTETIKPLSILK- 768
QR Y GH+DD+ CL +HP + +ATGQV P + IWD+ T+ L ++
Sbjct: 262 QLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGI 321
Query: 769 GHHQYGVSAVDFSAD--GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNP 826
G V+ + FS G L +V + H + +WDW+K EKL+ + S + +F +P
Sbjct: 322 GFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHP 381
Query: 827 YVPDKLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGD 886
+ ++T G H+ FW G L ++G K ++C + + +G S+G+
Sbjct: 382 TDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGD-TITGDSSGN 440
Query: 887 VCIW-----RDIFLVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTY 939
+ +W R + V+ AH+G +F++ L G + GGKD + W ++++ KT
Sbjct: 441 ILVWGKGTNRISYAVQ--GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 498
Query: 940 AIKRAALAPGSKGLLLEDNPSIRAISLGHGH-ILVGTKNGEILEVDKSGPITLLVQGHME 998
+ E IR ++ G G IL+GT +L+ SG T + QGH +
Sbjct: 499 --------------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD 544
Query: 999 GEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVG 1058
E+WGLA H T DK +WD + H + + ++ + F P G +AVG
Sbjct: 545 -ELWGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVG 602
Query: 1059 LNDGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS-- 1115
G + + + +T +DLV+ H + +S +R+SP G +LA+ SHD+ I IY V +
Sbjct: 603 TLTGRWFVFDTET-KDLVTVHTDGNEQLSVMRYSP-DGNFLAIGSHDNCIYIYGVSDNGR 660
Query: 1116 --KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWA 1173
RVG C G +S+ITH+DW + + L N+G E L++ P KQ + I WA
Sbjct: 661 KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWA 719
Query: 1174 SWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKR 1233
++T LG G+WP + TD+ A C +K +L+TGDD G V LF YP
Sbjct: 720 TYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHI 779
Query: 1234 YVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
Y HS+HVTNV + +DS L++ GG D S+M W
Sbjct: 780 YGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQW 812
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 365 bits (937), Expect = e-100
Identities = 220/699 (31%), Positives = 360/699 (51%), Gaps = 47/699 (6%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
P L+LEW YGYRG CR N+Y EIVYF+A V V+++ E Q+ Y GH+D +
Sbjct: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 256
Query: 67 LALHPERVLVATGQVGK--------EPYICIWDSYTVQTISVLK-DVHTHGIACLAFDL- 116
LA+HP+++ +ATGQ+ +P++ +WDS T+ T+ ++ G+ CL F
Sbjct: 257 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 316
Query: 117 -DGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
G L + +++ + VWDW++ + + + + + N +++CG HI
Sbjct: 317 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 376
Query: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW------------ 223
FW+ GN+LT K+G+FGK + + CLA + +G G + +W
Sbjct: 377 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 436
Query: 224 -KGINLIRTIQGAHAAGIFSMNACEEGFAT--GGRDGCIRLWDLTFKPITVIDLRETDQG 280
KG+ I AH +F++ G GG+D I LWD P I++ +
Sbjct: 437 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYG- 495
Query: 281 YKGLSVRSVC-WRGDHILVGTQDSEIFEIVVQERNKPFLI-MQGHCEGELWALAVHPTKP 338
++R+V + D LVGT + I N F I +QGH + ELW LA HP K
Sbjct: 496 ----TIRAVAEGKADQFLVGTSRNFILRGTF---NDGFQIEVQGHTD-ELWGLATHPFKD 547
Query: 339 LAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDM 398
L +T + DR V +W+ ++H L ++EP CA + G +A+G G + VL
Sbjct: 548 LLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETR 607
Query: 399 TEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ---RYKKVGECLGSLSFIT 455
V D E + ++YS DGT+LAVG +D+ + +Y V++ +Y + G C G S+IT
Sbjct: 608 DLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYIT 667
Query: 456 HLDWSSDSRYLQTNDGNGKRLFYRMPGG-KEVTSTEEIKGVHWASWTCVSGLEVNGIWPK 514
HLDWS D++Y+ +N G+ + L++ +P G K + + + K + W ++TCV G +V G+WP+
Sbjct: 668 HLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 727
Query: 515 YSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHD 574
SD DIN++ ++ +V+ ADD+ + LF+YPC + A KY HS+HVTNV ++H+
Sbjct: 728 GSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHN 787
Query: 575 YQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLSDVP------E 628
+IS GG D S+ QWK + + L +A S S+ P
Sbjct: 788 DSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP 847
Query: 629 LDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSK 667
L+ E+E++++ + + L Q E ++ + + +
Sbjct: 848 LNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEE 886
Score = 350 bits (898), Expect = 8e-96
Identities = 216/631 (34%), Positives = 333/631 (52%), Gaps = 52/631 (8%)
Query: 669 RERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDD 728
R P ++L + +GYRG DCR+N++ GEIVY +A+V V++N ++ TQR YLGH D
Sbjct: 193 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 252
Query: 729 DILCLTIHPLKDYVATGQV------GR--DPSIHIWDTETIKPLSILK-GHHQYGVSAVD 779
+ CL IHP K +ATGQ+ GR P + +WD+ T+ L I+ G + GV +D
Sbjct: 253 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
Query: 780 FSADGKRLASVGIDDS--HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI 837
FS + IDDS H + +WDW+K K + + + + + V+ +P + +IT G
Sbjct: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
Query: 838 KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW------- 890
H+ FW +G L ++G G K + C + ++ +G S G + IW
Sbjct: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDV-LTGDSGGVMLIWSKTTVEP 431
Query: 891 ------RDIFLV-KTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTYAI 941
+ ++ + K +KAHDG VF++ + G + GGKD + LWD
Sbjct: 432 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP------- 484
Query: 942 KRAALAPGSKGLLLEDNPSIRAISLGHG-HILVGTKNGEILEVDKSGPITLLVQGHMEGE 1000
+R P G +IRA++ G LVGT IL + + VQGH + E
Sbjct: 485 EREIEVPDQYG-------TIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 536
Query: 1001 VWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLN 1060
+WGLATHP+ + T + D+ + +W+ S H + R + + G C F P G +A+G +
Sbjct: 537 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 595
Query: 1061 DGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS---- 1115
G + + +A+T DLVS H + +S +R+S G +LAV SHD+FI +Y V +
Sbjct: 596 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSI-DGTFLAVGSHDNFIYLYVVSENGRKY 653
Query: 1116 KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASW 1175
R G C G +SYITH+DW K + N+G E L+++ P G K + + I W ++
Sbjct: 654 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
Query: 1176 TSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYV 1235
T VLG G+WP + TD+ A + ++ V+A DD V LF+YP +Y
Sbjct: 714 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 773
Query: 1236 AHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
AHS+HVTNV +T++DS L++ GG DMS++ W
Sbjct: 774 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 804
Score = 311 bits (796), Expect = 5e-84
Identities = 203/628 (32%), Positives = 312/628 (49%), Gaps = 38/628 (6%)
Query: 1367 PIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDIL 1426
P E L LE +GYRG+DCR NV+ L G+ I+Y ASV +L N +Q Y H D +
Sbjct: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGE-IVYFIASVVVLFNYEERTQRHYLGHTDCVK 255
Query: 1427 CLTVNQHPKFINIVATGQV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVS 1484
CL + HP I I ATGQ+ G D P + +WD++ TL I+ +GV +
Sbjct: 256 CLAI--HPDKIRI-ATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
Query: 1485 FSA--TGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGV 1542
FS +G L + EH +T+W WQ+ AK A N+ + EF P ++ G
Sbjct: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
Query: 1543 KHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVW------ 1596
H+ FWT +G +L K+G+ E + + +AF N TG G + +W
Sbjct: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTTVE 430
Query: 1597 -------KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGG-KERPSKEGGAVKLWDQELR 1648
K +AH+G VF + +R+G+++TGG K+R + LWD +L
Sbjct: 431 PTPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLN 483
Query: 1649 RCRAFRLETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWG 1707
R + T +R+V GK + LVGT I+ G N I V GH D +WG
Sbjct: 484 PEREIEVPDQYGT--IRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWG 539
Query: 1708 LATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEF 1767
LATHP +D L+ A+D V LW+ + ++ + + P G +VAIG +G +
Sbjct: 540 LATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRW 599
Query: 1768 IILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTL-GPTLNRISYC 1826
+L + + D + +R+S D +LAVGS +N + Y ++ G +R C
Sbjct: 600 FVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRC 659
Query: 1827 KDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSG-KHLMDHAAIDRITWATWTSILGD 1885
S++ +D+S D+ Y+ +SG Y+ +++P+G K + + + I W T+T +LG
Sbjct: 660 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGF 719
Query: 1886 EVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHV 1945
+V G+W ++ D+N SH+ + DDF V LF +PC + A ++ HS HV
Sbjct: 720 QVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHV 779
Query: 1946 TNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
TN+ FT D H++S GG D S+ WK V
Sbjct: 780 TNVSFTHNDSHLISTGGKDMSIIQWKLV 807
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 365 bits (937), Expect = e-100
Identities = 220/699 (31%), Positives = 360/699 (51%), Gaps = 47/699 (6%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
P L+LEW YGYRG CR N+Y EIVYF+A V V+++ E Q+ Y GH+D +
Sbjct: 255 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 314
Query: 67 LALHPERVLVATGQVGK--------EPYICIWDSYTVQTISVLK-DVHTHGIACLAFDL- 116
LA+HP+++ +ATGQ+ +P++ +WDS T+ T+ ++ G+ CL F
Sbjct: 315 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 374
Query: 117 -DGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
G L + +++ + VWDW++ + + + + + N +++CG HI
Sbjct: 375 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 434
Query: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW------------ 223
FW+ GN+LT K+G+FGK + + CLA + +G G + +W
Sbjct: 435 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 494
Query: 224 -KGINLIRTIQGAHAAGIFSMNACEEGFAT--GGRDGCIRLWDLTFKPITVIDLRETDQG 280
KG+ I AH +F++ G GG+D I LWD P I++ +
Sbjct: 495 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYG- 553
Query: 281 YKGLSVRSVC-WRGDHILVGTQDSEIFEIVVQERNKPFLI-MQGHCEGELWALAVHPTKP 338
++R+V + D LVGT + I N F I +QGH + ELW LA HP K
Sbjct: 554 ----TIRAVAEGKADQFLVGTSRNFILRGTF---NDGFQIEVQGHTD-ELWGLATHPFKD 605
Query: 339 LAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDM 398
L +T + DR V +W+ ++H L ++EP CA + G +A+G G + VL
Sbjct: 606 LLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETR 665
Query: 399 TEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ---RYKKVGECLGSLSFIT 455
V D E + ++YS DGT+LAVG +D+ + +Y V++ +Y + G C G S+IT
Sbjct: 666 DLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYIT 725
Query: 456 HLDWSSDSRYLQTNDGNGKRLFYRMPGG-KEVTSTEEIKGVHWASWTCVSGLEVNGIWPK 514
HLDWS D++Y+ +N G+ + L++ +P G K + + + K + W ++TCV G +V G+WP+
Sbjct: 726 HLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 785
Query: 515 YSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHD 574
SD DIN++ ++ +V+ ADD+ + LF+YPC + A KY HS+HVTNV ++H+
Sbjct: 786 GSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHN 845
Query: 575 YQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLSDVP------E 628
+IS GG D S+ QWK + + L +A S S+ P
Sbjct: 846 DSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP 905
Query: 629 LDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSK 667
L+ E+E++++ + + L Q E ++ + + +
Sbjct: 906 LNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEE 944
Score = 350 bits (898), Expect = 8e-96
Identities = 216/631 (34%), Positives = 333/631 (52%), Gaps = 52/631 (8%)
Query: 669 RERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDD 728
R P ++L + +GYRG DCR+N++ GEIVY +A+V V++N ++ TQR YLGH D
Sbjct: 251 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 310
Query: 729 DILCLTIHPLKDYVATGQV------GR--DPSIHIWDTETIKPLSILK-GHHQYGVSAVD 779
+ CL IHP K +ATGQ+ GR P + +WD+ T+ L I+ G + GV +D
Sbjct: 311 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 370
Query: 780 FSADGKRLASVGIDDS--HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI 837
FS + IDDS H + +WDW+K K + + + + + V+ +P + +IT G
Sbjct: 371 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 430
Query: 838 KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW------- 890
H+ FW +G L ++G G K + C + ++ +G S G + IW
Sbjct: 431 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDV-LTGDSGGVMLIWSKTTVEP 489
Query: 891 ------RDIFLV-KTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTYAI 941
+ ++ + K +KAHDG VF++ + G + GGKD + LWD
Sbjct: 490 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP------- 542
Query: 942 KRAALAPGSKGLLLEDNPSIRAISLGHG-HILVGTKNGEILEVDKSGPITLLVQGHMEGE 1000
+R P G +IRA++ G LVGT IL + + VQGH + E
Sbjct: 543 EREIEVPDQYG-------TIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 594
Query: 1001 VWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLN 1060
+WGLATHP+ + T + D+ + +W+ S H + R + + G C F P G +A+G +
Sbjct: 595 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 653
Query: 1061 DGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS---- 1115
G + + +A+T DLVS H + +S +R+S G +LAV SHD+FI +Y V +
Sbjct: 654 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSI-DGTFLAVGSHDNFIYLYVVSENGRKY 711
Query: 1116 KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASW 1175
R G C G +SYITH+DW K + N+G E L+++ P G K + + I W ++
Sbjct: 712 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 771
Query: 1176 TSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYV 1235
T VLG G+WP + TD+ A + ++ V+A DD V LF+YP +Y
Sbjct: 772 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 831
Query: 1236 AHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
AHS+HVTNV +T++DS L++ GG DMS++ W
Sbjct: 832 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 862
Score = 311 bits (796), Expect = 5e-84
Identities = 203/628 (32%), Positives = 312/628 (49%), Gaps = 38/628 (6%)
Query: 1367 PIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDIL 1426
P E L LE +GYRG+DCR NV+ L G+ I+Y ASV +L N +Q Y H D +
Sbjct: 255 PPEKLKLEWAYGYRGKDCRANVYLLPTGE-IVYFIASVVVLFNYEERTQRHYLGHTDCVK 313
Query: 1427 CLTVNQHPKFINIVATGQV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVS 1484
CL + HP I I ATGQ+ G D P + +WD++ TL I+ +GV +
Sbjct: 314 CLAI--HPDKIRI-ATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 370
Query: 1485 FSA--TGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGV 1542
FS +G L + EH +T+W WQ+ AK A N+ + EF P ++ G
Sbjct: 371 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 430
Query: 1543 KHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVW------ 1596
H+ FWT +G +L K+G+ E + + +AF N TG G + +W
Sbjct: 431 SHIFFWTWSGNSLTRKQGIFGKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTTVE 488
Query: 1597 -------KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGG-KERPSKEGGAVKLWDQELR 1648
K +AH+G VF + +R+G+++TGG K+R + LWD +L
Sbjct: 489 PTPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLN 541
Query: 1649 RCRAFRLETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWG 1707
R + T +R+V GK + LVGT I+ G N I V GH D +WG
Sbjct: 542 PEREIEVPDQYGT--IRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWG 597
Query: 1708 LATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEF 1767
LATHP +D L+ A+D V LW+ + ++ + + P G +VAIG +G +
Sbjct: 598 LATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRW 657
Query: 1768 IILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTL-GPTLNRISYC 1826
+L + + D + +R+S D +LAVGS +N + Y ++ G +R C
Sbjct: 658 FVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRC 717
Query: 1827 KDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSG-KHLMDHAAIDRITWATWTSILGD 1885
S++ +D+S D+ Y+ +SG Y+ +++P+G K + + + I W T+T +LG
Sbjct: 718 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGF 777
Query: 1886 EVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHV 1945
+V G+W ++ D+N SH+ + DDF V LF +PC + A ++ HS HV
Sbjct: 778 QVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHV 837
Query: 1946 TNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
TN+ FT D H++S GG D S+ WK V
Sbjct: 838 TNVSFTHNDSHLISTGGKDMSIIQWKLV 865
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 323 bits (828), Expect = 1e-87
Identities = 208/631 (32%), Positives = 321/631 (50%), Gaps = 55/631 (8%)
Query: 11 LRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVY-------SPREHRQKFYRGHSDD 63
L L+WVYGYRG R+NL+ + E+VYF+A V V+Y P Q+ YRGH+D
Sbjct: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDC 307
Query: 64 IISLALHPERVLVATGQV------GK--EPYICIWDSYTVQTISVLK-DVHTHGIACLAF 114
+ LA+HP+ V VA+GQ GK +P + IWDS T+ + + G+ LAF
Sbjct: 308 VRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAF 367
Query: 115 DLDGQRLVSVGLDSKNA--VCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVK 172
Q +D N + VWD RG L+ D + + ++ + +V+ G
Sbjct: 368 SAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKS 427
Query: 173 HIKFWSLCGNA-------LTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-- 223
H+ FW+ G LT K+GVFGK + I C D +G G+I W
Sbjct: 428 HVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGR 487
Query: 224 -------------KGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKP 268
K I AH IF++ +G + GGRD + W
Sbjct: 488 SPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPG--- 544
Query: 269 ITVIDLRETDQGYKGLSVRSVC-WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGE 327
++ L+E + +VR++ G +LVGT + + + + P ++QGH + E
Sbjct: 545 --LVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP--VIQGHTD-E 599
Query: 328 LWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKD 387
LW L HP++ +T DR + +W HAL +++E CA + G +A+G+
Sbjct: 600 LWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNT 659
Query: 388 GSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ---RYKKV 444
G + VL V + D E + ++YSPDG YLA+G +D+ + IY V+ + +
Sbjct: 660 GRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRF 719
Query: 445 GECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGG-KEVTSTEEIKGVHWASWTCV 503
G C+G SFITHLDWS D ++ +N G+ + L++ + GG K++ + E + WA++TCV
Sbjct: 720 GRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCV 779
Query: 504 SGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHS 563
G V G+WP SD DINS+ ++ +V+ ADD+ + LF+YPC R A R Y GH
Sbjct: 780 LGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHG 839
Query: 564 AHVTNVRWSHDYQWVISIGGADHSVFQWKFI 594
+HVT+VR++HD ++S+GG D S+FQW+ +
Sbjct: 840 SHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
Score = 323 bits (827), Expect = 1e-87
Identities = 219/642 (34%), Positives = 321/642 (50%), Gaps = 66/642 (10%)
Query: 673 PGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNT-------QRFYLG 725
P ++ L +V+GYRG D RSNLF + GE+VY +A V V+Y QR Y G
Sbjct: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
Query: 726 HDDDILCLTIHPLKDYVATGQ---VGRD-----PSIHIWDTETIKPLS-ILKGHHQYGVS 776
H D + CL +HP VA+GQ V +D P +HIWD+ET+ L I G + GV
Sbjct: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
Query: 777 AVDFSADGKRLASVGIDDS--HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLIT 834
A+ FSA + +DDS H + +WD +G KL+ + + D + V NP ++T
Sbjct: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
Query: 835 AGIKHMKFWRKAGG------GLIGRK-GYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDV 887
+G H+ FW +GG G + RK G G K + C V+ + +G S G++
Sbjct: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVF-LPDGDILTGDSEGNI 482
Query: 888 CIW----------------RDIFLVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWD 929
W +V AH+G +F++ G V GG+D + W
Sbjct: 483 LTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWG 542
Query: 930 DSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHG-HILVGTKNGEILEVDKSGP 988
A++ A + E ++RAI+ G G +LVGT +L D +
Sbjct: 543 PGL------VALQEAEIP--------EHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG 588
Query: 989 ITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCF 1048
+ ++QGH + E+WGL THP T D+ L +WD SH + LK+ G C F
Sbjct: 589 FSPVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWD-GESHALAWSIDLKETGLCADF 646
Query: 1049 SPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFID 1108
P G +AVGLN G +L+ + +T E + + +S +R+SP G YLA+ SHD+ I
Sbjct: 647 HPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSP-DGLYLAIGSHDNVIY 705
Query: 1109 IYNVMS----SKRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPS 1164
IY+V S S R G C G +S+ITH+DW G + N+G E L+++ G KQ
Sbjct: 706 IYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNR 765
Query: 1165 VEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPT 1224
E WA++T VLG G+WP + TD+ + C + ++ V+A DD V LF+YP
Sbjct: 766 YESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPC 825
Query: 1225 KGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
+ Y H +HVT+VR+T+DDS LV+LGG D S+ W
Sbjct: 826 ARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
Score = 277 bits (708), Expect = 8e-74
Identities = 186/639 (29%), Positives = 299/639 (46%), Gaps = 48/639 (7%)
Query: 1367 PIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATG-------SQSFYQ 1419
P E L L+ ++GYRGRD R+N+ L G+ ++Y A V +L+ G Q Y+
Sbjct: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGE-VVYFIACVVVLYRPGGGPGGPGGGGQRHYR 302
Query: 1420 EHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRC-YHSK 1478
H D + CL V HP + + + G D P +HIWD+ L + +
Sbjct: 303 GHTDCVRCLAV--HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
Query: 1479 GVCSVSFSAT--GKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQ 1536
GV +++FSA G L V EH +++W G K+A N + F P +
Sbjct: 361 GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC 420
Query: 1537 FVSVGVKHVKFWTLAGRALLSKKGLLSTLEDA-----RMQTMLAIAFGANNLTFTGTISG 1591
V+ G HV FW +G + G L+ + + + + F + TG G
Sbjct: 421 IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG 480
Query: 1592 DVCVW---------------KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGG-KERPSK 1635
++ W K+ A AH G +FA+ RDG +++GG ++R
Sbjct: 481 NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR-RDGTVLSGGGRDRRLV 539
Query: 1636 EGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACN 1694
+ G + QE E + VR++ G G ++LVGT ++ G+ +
Sbjct: 540 QWGPGLVALQEA--------EIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFS 590
Query: 1695 ILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPE 1754
++ GH D +WGL THPS++ FL+ D + LWD + ++L + P
Sbjct: 591 PVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPS 649
Query: 1755 GDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDL 1814
G +VA+G+ G +++L + +I D + +R+SPD YLA+GS +N + Y +
Sbjct: 650 GAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSV 709
Query: 1815 TL-GPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSG-KHLMDHAAID 1872
+ G +R C SF+ +D+S D +++ +SG Y+ ++V G K L +
Sbjct: 710 SSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESR 769
Query: 1873 RITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKF 1932
WAT+T +LG V G+W ++ D+N C SH+ + DDF V LF +PC
Sbjct: 770 DREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAK 829
Query: 1933 AKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWK 1971
A + + GH HVT++RFT D H+VS GG D S+F W+
Sbjct: 830 APSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWR 868
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 150 bits (380), Expect = 9e-36
Identities = 285/1224 (23%), Positives = 448/1224 (36%), Gaps = 183/1224 (14%)
Query: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
P LRL+ V G+ GH R L+ +VY V VV Q+F+ GH+D + +
Sbjct: 355 PDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSA 414
Query: 67 LALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGL 126
LAL L+A+ Q + +WD T + + + + H + L+F G L VG
Sbjct: 415 LALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-MHVVCSLSFSDSGALLCGVGK 473
Query: 127 DSKNAVCVWDWKRGKM------LSMAPGHTDRIFDISW---DLYQPNKLVSCGVKHIKFW 177
D V W G++ + +A HTD FD+ + ++ SCG ++ W
Sbjct: 474 DHHGRTMVVAWGTGQVGLGGEVVVLAKAHTD--FDVQAFRVTFFDETRMASCGQGSVRLW 531
Query: 178 SLCGNALTPKRGVFGKTGDLQ-TILCLACARD-------ELTYSGALNGDIYVWKGINLI 229
L G L G+ LQ T L ARD + + + +G I ++
Sbjct: 532 RLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMV 591
Query: 230 ----------RTIQGAH----------AAGIFSMNACEEGFATGGRDGCIRLWDLTFKPI 269
RT G H I S++ A G DG +RLW L F +
Sbjct: 592 VRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSV 651
Query: 270 TVIDLRE--------TDQGYKGLSVRS--------VCWRGDHILVGTQDSEIFEIVVQER 313
+ E + G + LS S R H+L + + + + +++R
Sbjct: 652 LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQR 711
Query: 314 NKPFLIMQGHCEGELWALAV-------------------HPTKPLAVTGSDDRSVRIWSL 354
+ +W LA HPT+P G +VR +SL
Sbjct: 712 RGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSL 771
Query: 355 -VDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFT----------VLRVR-DMTEVV 402
L+ + DG L GS VLRV DM
Sbjct: 772 EAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMV--- 828
Query: 403 HIKDRKEAIHELKYSPDGTYLA-VGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSS 461
D + L S DG LA VG + +V + G A + + +G+L +
Sbjct: 829 -CPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDL-------A 880
Query: 462 DSRYLQTNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGL---EVNGIWPKYSDI 518
SR D F G + ST + V VSG E+ G+ P+
Sbjct: 881 SSRL----DSAMAVCFGPAALGHLLVSTSSNRVV---VLDAVSGRIIRELPGVHPEPCPS 933
Query: 519 NDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWV 578
+ S D ++ L+ A IK++ Y + YIGHS V V +S D Q V
Sbjct: 934 LTL-SEDARFL---LIAAGR--TIKVWDYATQASPGP-QVYIGHSEPVQAVAFSPDQQQV 986
Query: 579 ISIGGADHSVFQWKFIPERKLKDAVHIAPQES--------LADSHSDESDSDLSDVPELD 630
+S G A VF W + + + AP L D+ S S+ VP+
Sbjct: 987 LSAGDA---VFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPC 1043
Query: 631 SEIEQETQLTYR--------RQVYKEDLPQLK--EQCKE--------KQKSATSKRRERA 672
+ R R P+ CK SA A
Sbjct: 1044 QASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPA 1103
Query: 673 PGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILC 732
G +RL V GY G + ++ G Y + V+ + Q+ + GH +I
Sbjct: 1104 SGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEIST 1163
Query: 733 LTIHPLKDYVATGQVGRDPS-----IHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRL 787
L + +A+ GR + I +WD L H V A+ FS D + L
Sbjct: 1164 LALSHSAQVLASAS-GRSSTTAHCQIRVWDVSG-GLCQHLIFPHSTTVLALAFSPDDRLL 1221
Query: 788 ASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFW--RK 845
++G D T+ LW + +S R + + V NP+ +L G + FW ++
Sbjct: 1222 VTLGDHDGRTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQ 1280
Query: 846 AGGGL---IGRKGYIGTLGKND-TMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTV 899
G + + R+ +G + T +C YG + + GTS+G VC+W R +
Sbjct: 1281 RGADISLQVRREPVPEAVGAGELTSLC--YG-APPLLYCGTSSGQVCVWDTRAGRCFLSW 1337
Query: 900 KAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNP 959
+A DG + + V+G G + LW L+ A + + L+ D
Sbjct: 1338 EADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKG--SGASSVFMEHELVLDGA 1395
Query: 960 SIRA-----ISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPYLPIC 1013
+ A + +G +VGT G + V G T L+ GH +V + P C
Sbjct: 1396 VVSASFDDSVDMG----VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHC 1450
Query: 1014 ATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRC------CCFSPDGKALAVGLNDGSFLMA 1067
AT S+D ++R+W L+ ++ + L + C CC P+ + LA G DGS +
Sbjct: 1451 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIF 1510
Query: 1068 NADTLEDLVSFHHRKDMISDIRFS 1091
+ + H ++ + FS
Sbjct: 1511 SVSRTAMELKMHPHPVALTTVAFS 1534
Score = 76.3 bits (186), Expect = 3e-13
Identities = 110/477 (23%), Positives = 181/477 (37%), Gaps = 51/477 (10%)
Query: 1368 IEDLVLEL--IFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDI 1425
+ D VL L + G+ G R + + DG ++Y +V ++ V TG Q F+ H D +
Sbjct: 354 LPDPVLRLKGVIGFGGHGTRQAL-WTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKV 412
Query: 1426 LCLTVNQHPKFINIVATGQVGDSADMSATAPSI-HIWDAMNKQTLSILRCYHSKGVCSVS 1484
L ++ + A A APS+ +WD + L + R VCS+S
Sbjct: 413 SALALDGSSSLL-----------ASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLS 460
Query: 1485 FSATGKLLLSVGLDPEHTITIWRWQE-----GAKIASRAGHNQRIFVAEFRPD--SDTQF 1537
FS +G LL VG D + W G ++ A + V FR +T+
Sbjct: 461 FSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRM 520
Query: 1538 VSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWK 1597
S G V+ W L G L S L A T LA + VC
Sbjct: 521 ASCGQGSVRLWRLRGGVLRSCPVDLGE-HHALQFTDLAFKQARDGCPEPSAAMLFVCSRS 579
Query: 1598 DHIL---CR----------IVARAHNGPVFAMYT-TLRDGLIVTGGKERPS-----KEGG 1638
HIL C+ + R GP T + G+ ++ P+ E G
Sbjct: 580 GHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDG 639
Query: 1639 AVKLWDQELRRCRAFRLETGQATDCVRSVCRGKG--KILVGTRNAEIIEVGEKNAACNIL 1696
++LW + L + V SVC ++L T + + + + ++L
Sbjct: 640 FLRLWPLDFSSV----LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHML 695
Query: 1697 VNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIAD-KKMLNKVNLGHAARTVCYSPEG 1755
H P+ LA R + ++D TVR+WD+A +++ + + A V + P
Sbjct: 696 ARSHT-APVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
Query: 1756 DMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFY 1812
G +G + + ++ + R A+ + +PD R L S+ S+ Y
Sbjct: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQY 811
Score = 75.9 bits (185), Expect = 4e-13
Identities = 109/487 (22%), Positives = 191/487 (39%), Gaps = 63/487 (12%)
Query: 1371 LVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTV 1430
L L+ + GY G R N+ + D Y + ++ ++ +G+Q + H+ +I L +
Sbjct: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
Query: 1431 NQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK 1490
+ H + A+G+ +A I +WD ++ HS V +++FS +
Sbjct: 1167 S-HSAQVLASASGRSSTTAHCQ-----IRVWDVSGGLCQHLI-FPHSTTVLALAFSPDDR 1219
Query: 1491 LLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL 1550
LL+++G T+ +W + S + + F P + VG V FW
Sbjct: 1220 LLVTLGDHDGRTLALWGTAT-YDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFW-- 1276
Query: 1551 AGRALLSKKGLLSTLEDARMQT--------MLAIAFGANNLTFTGTISGDVCVWKDHI-L 1601
LL ++G +L+ R + ++ +GA L + GT SG VCVW
Sbjct: 1277 ----LLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGR 1332
Query: 1602 CRIVARAHNGPVFAMYTTLRDGLIVTGGKERPS-KEGGAVKLWD----QELRRCRAFRLE 1656
C + A +G + GL++ G S G ++LW EL RC+
Sbjct: 1333 CFLSWEADDGGI---------GLLLFSGSRLVSGSSTGRLRLWAVGAVSEL-RCKG---- 1378
Query: 1657 TGQATDCVRSVCRGKGKI------------LVGTRNAEIIEVGEKNAACNILVNGHVDGP 1704
+G ++ + G + +VGT + V L++GH
Sbjct: 1379 SGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGH-RSK 1437
Query: 1705 IWGLATHPSRDFFLSAAEDGTVRLWDIADKKM------LNKVNLGHA-ARTVCYSPEGDM 1757
+ + P + +EDG+VR+W +A ++ LN+ L A + C PE
Sbjct: 1438 VNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQR 1497
Query: 1758 VAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+A G +G I VS + K A+ + FS D + + G + V G
Sbjct: 1498 LAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTG 1557
Query: 1818 PTLNRIS 1824
T +S
Sbjct: 1558 TTFRVLS 1564
Score = 72.0 bits (175), Expect = 5e-12
Identities = 105/526 (19%), Positives = 190/526 (36%), Gaps = 63/526 (11%)
Query: 607 PQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATS 666
P+ SL+ SD S++D L+ + E + L + E + T
Sbjct: 292 PEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTH---VLTHESAEVPVARTG 348
Query: 667 KRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGH 726
P +RL V G+ G+ R L+ +VY AV V+ QRF+LGH
Sbjct: 349 SCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGH 408
Query: 727 DDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKR 786
D + L + +A+ Q + +WD +T + L + + + V ++ FS G
Sbjct: 409 TDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLSFSDSGAL 467
Query: 787 LASVGIDDSHTVVLWDWKK------GEKLSIARGSKD-KIFVVKMNPYVPDKLITAGIKH 839
L VG D ++ W GE + +A+ D + ++ + ++ + G
Sbjct: 468 LCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGS 527
Query: 840 MKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTE----------EMAFSGTSTGDV-- 887
++ WR GG L + LG++ + + + M F + +G +
Sbjct: 528 VRLWRLRGGVL---RSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILE 584
Query: 888 -----CIWRDIFLVKTVKAHDGP--------------VFSMHALEKGFVTGGKDGIVALW 928
+ R + + GP + S+ G +DG + LW
Sbjct: 585 IDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLW 644
Query: 929 DDSFERCLKTYAIKRAALAPGSKGLLLEDNPSI-RAISLGH-GHILVGTKNGEILEVDKS 986
F L ++ P S + D + A S GH G + ++ +L +
Sbjct: 645 PLDFSSVL----LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHT 700
Query: 987 GPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCC 1046
P+ L G++ ATVS D+T+RIWDL+ + +
Sbjct: 701 APVLALAMEQRRGQL------------ATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAV 748
Query: 1047 CFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSP 1092
F P G + G+ + + E LV + ++ + +P
Sbjct: 749 TFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATP 794
Score = 61.6 bits (148), Expect = 7e-09
Identities = 101/458 (22%), Positives = 169/458 (36%), Gaps = 48/458 (10%)
Query: 11 LRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLAL- 69
LRL+ V GY G+ N ++ Y + VV Q+ + GHS +I +LAL
Sbjct: 1108 LRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALS 1167
Query: 70 HPERVLV-ATGQVGKEPY--ICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGL 126
H +VL A+G+ + I +WD + L H+ + LAF D + LV++G
Sbjct: 1168 HSAQVLASASGRSSTTAHCQIRVWD-VSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGD 1226
Query: 127 DSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSL----CGN 182
+ +W ++S + + + ++++ + +L G + FW L
Sbjct: 1227 HDGRTLALWGTATYDLVS-STRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADI 1285
Query: 183 ALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLIRTIQGAHAAGIF 241
+L +R + + L L Y G +G + VW A GI
Sbjct: 1286 SLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIG 1345
Query: 242 SMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQ 301
+ +G G +RLW + V +LR KG SV + +L G
Sbjct: 1346 LLLFSGSRLVSGSSTGRLRLWAVG----AVSELR-----CKGSGASSVFMEHELVLDGAV 1396
Query: 302 DSEIFE----------------IVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSD 345
S F+ V ++ GH ++ + P + T S+
Sbjct: 1397 VSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHCATCSE 1455
Query: 346 DRSVRIWSLVDHALIAR---------CNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVR 396
D SVR+W+L L+ + C P C + LA G DGS + V
Sbjct: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCG--RPEQQRLAAGYGDGSLRIFSVS 1513
Query: 397 DMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDI 434
+ + A+ + +S DG + G D V +
Sbjct: 1514 RTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
Score = 32.3 bits (72), Expect = 4.7
Identities = 27/113 (23%), Positives = 42/113 (37%)
Query: 1721 AEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGK 1780
+EDG +RLW + +L + +VC SP+G V +G L S
Sbjct: 636 SEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHML 695
Query: 1781 KRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFV 1833
R + + LA S + +V +DL L + +D P V
Sbjct: 696 ARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAV 748
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 134 bits (337), Expect = 9e-31
Identities = 132/512 (25%), Positives = 223/512 (43%), Gaps = 66/512 (12%)
Query: 679 LHFVHGYRGYDCRSNLFYTQIGE-IVYHVAAVGVIYNRQQNTQRFYL--GHDDDILCLTI 735
L VH + GYDCR + + I ++A +I+ + ++ YL + I + +
Sbjct: 133 LTLVHSF-GYDCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEGIGVIGV 191
Query: 736 HPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDS 795
HP K Y + G P I I++ +++P +L+ + G + VDF+ G LASVG +
Sbjct: 192 HPHKTYFTVAEKGSFPDIIIYEYPSLRPYRVLRDGTEKGYAYVDFNYSGNLLASVGSNPD 251
Query: 796 HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRKAGGGL-IGRK 854
+T+ +W+WK+ + + + ++F V NP ++L T+G H+KFW A + +
Sbjct: 252 YTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQ 311
Query: 855 GYIGTLGKNDTMMCAVYGWTE---EMAFSGTSTGDVCIWR------DIFLVKTVKAHDGP 905
G +G GK T+ + G+ E SG+ G++ +W ++ + H+GP
Sbjct: 312 GSLGRFGK--TITTDIEGYMELPDGKVLSGSEWGNMLLWEGGLIKVELCRGTSKSCHNGP 369
Query: 906 VFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAIS 965
+ + E +T G DG V +WD FE I L L+ + ++ S
Sbjct: 370 INQIMLYEGEVITVGSDGYVRIWD--FETIDTADVIDETGLLEIEPINELQVDKNVNLFS 427
Query: 966 L------GHGHILVGTKNGEILEVDKS-GPIT----LLVQGHMEGEVWGLATHPYLPICA 1014
+ G+ L NG I ++D S IT L H G + +A P + A
Sbjct: 428 MIKMNETGNNFWLAQDANGAIWKLDLSFSNITQDPECLFSFH-SGAIEAVAVSPLTYLMA 486
Query: 1015 TVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSP-----DGKALAVGLNDGSFLMANA 1069
T + D ++RI+D + S LA K K+GG + P G + VG DG +
Sbjct: 487 TTALDCSVRIYDFA-SKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVVRILEL 545
Query: 1070 DTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYIT 1129
+ L F RK ++ D+ I + V K T+ +T
Sbjct: 546 YDPKGLTIFAGRKKIL------------------DADIQLKQVF--------KPHTACVT 579
Query: 1130 HIDWDIRGKLLQVNTGAKEQ--LFFEAPRGKK 1159
+ ++ G++L TG+K+Q FFE R K
Sbjct: 580 ALAYERDGEILA--TGSKDQTVFFFEVERDYK 609
Score = 112 bits (279), Expect = 5e-24
Identities = 113/477 (23%), Positives = 198/477 (41%), Gaps = 56/477 (11%)
Query: 21 GHQCRNNLYYTAAKE-IVYFVAGVGVVYSPREHRQKFYRGHS--DDIISLALHPERVLVA 77
G+ CR + I ++AG +++ + +++ Y S + I + +HP +
Sbjct: 140 GYDCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEGIGVIGVHPHKTYFT 199
Query: 78 TGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDW 137
+ G P I I++ +++ VL+D G A + F+ G L SVG + + +W+W
Sbjct: 200 VAEKGSFPDIIIYEYPSLRPYRVLRDGTEKGYAYVDFNYSGNLLASVGSNPDYTLTIWNW 259
Query: 138 KRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLC----GNALTPKRGVFGK 193
K + + + +F ++++ + +L + G HIKFW + G L G FGK
Sbjct: 260 KEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGK 319
Query: 194 T--GDLQTILCLACARDELTYSGALNGDIYVWKG----INLIR-TIQGAHAAGIFSMNAC 246
T D++ + L D SG+ G++ +W+G + L R T + H I +
Sbjct: 320 TITTDIEGYMELP---DGKVLSGSEWGNMLLWEGGLIKVELCRGTSKSCHNGPINQIMLY 376
Query: 247 EEGFATGGRDGCIRLWDL-TFKPITVIDLR-----------ETDQGYKGLSVRSVCWRGD 294
E T G DG +R+WD T VID + D+ S+ + G+
Sbjct: 377 EGEVITVGSDGYVRIWDFETIDTADVIDETGLLEIEPINELQVDKNVNLFSMIKMNETGN 436
Query: 295 HI-LVGTQDSEIFEIVVQERN---KPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350
+ L + I+++ + N P + H G + A+AV P L T + D SVR
Sbjct: 437 NFWLAQDANGAIWKLDLSFSNITQDPECLFSFH-SGAIEAVAVSPLTYLMATTALDCSVR 495
Query: 351 IWSLVDHALIARCNMEEPIRCAA-----VNADGIHLALGMKDGSFTVLRVRDMTEVVHIK 405
I+ +A+ ++ VN G + +G +DG +L + D +
Sbjct: 496 IYDFASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVVRILELYDPKGLTIFA 555
Query: 406 DRKE-----------------AIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVG 445
RK+ + L Y DG LA G D +V + V + YK +G
Sbjct: 556 GRKKILDADIQLKQVFKPHTACVTALAYERDGEILATGSKDQTVFFFEVERDYKPIG 612
Score = 105 bits (261), Expect = 6e-22
Identities = 115/501 (22%), Positives = 200/501 (39%), Gaps = 78/501 (15%)
Query: 1367 PIEDLVLELIFGYRGRDCRNNVHY-LNDGDDIIYHTASVGILHNVATGSQSFYQEHNDD- 1424
P++ L L FGY DCR + L D IY + I N+ T Q + + + +
Sbjct: 129 PLDLLTLVHSFGY---DCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEG 185
Query: 1425 ILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVS 1484
I + V+ H + + G P I I++ + + +LR KG V
Sbjct: 186 IGVIGVHPHKTYFTVAEKGSF----------PDIIIYEYPSLRPYRVLRDGTEKGYAYVD 235
Query: 1485 FSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKH 1544
F+ +G LL SVG +P++T+TIW W+E I +Q +F F PD + Q + G H
Sbjct: 236 FNYSGNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGH 295
Query: 1545 VKFW----TLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHI 1600
+KFW T G L G ++ + + G +G+ G++ +W+ +
Sbjct: 296 IKFWEMAFTFTGLKLQGSLGRFGKTITTDIEGYMELPDGK---VLSGSEWGNMLLWEGGL 352
Query: 1601 ----LCRIVARA-HNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRL 1655
LCR +++ HNGP+ + L +G ++T G + G V++WD E
Sbjct: 353 IKVELCRGTSKSCHNGPINQI--MLYEGEVITVGSD------GYVRIWDFETIDTADVID 404
Query: 1656 ETG----------------QATDCVRSVCRGKGKILVGTRNAEI--IEVGEKNAACN--I 1695
ETG ++ G L N I +++ N +
Sbjct: 405 ETGLLEIEPINELQVDKNVNLFSMIKMNETGNNFWLAQDANGAIWKLDLSFSNITQDPEC 464
Query: 1696 LVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPE- 1754
L + H G I +A P + A D +VR++D A K L ++ + + P
Sbjct: 465 LFSFH-SGAIEAVAVSPLTYLMATTALDCSVRIYDFASKTPLAQMKFKQGGTALVWVPRM 523
Query: 1755 ----GDMVAIGMKNGEFIIL-----------------LVSSLKIWGKKRDRRCAIHDIRF 1793
G + +G ++G IL L + +++ + + + +
Sbjct: 524 VNFTGAQIIVGFEDGVVRILELYDPKGLTIFAGRKKILDADIQLKQVFKPHTACVTALAY 583
Query: 1794 SPDSRYLAVGSSENSVDFYDL 1814
D LA GS + +V F+++
Sbjct: 584 ERDGEILATGSKDQTVFFFEV 604
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 82.4 bits (202), Expect = 4e-15
Identities = 75/269 (27%), Positives = 116/269 (43%), Gaps = 20/269 (7%)
Query: 682 VHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHD-DDILCLTIHPLKD 740
V G RG C + G + Y V V++N +++ Q L I L P
Sbjct: 49 VSGGRGLACDP-----RSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 741 YVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVL 800
Y+ TG+ G P++ +WD ++ L+ H+YGV+ V FS K + SVG V +
Sbjct: 104 YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
Query: 801 WDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWR---------KAGGGLI 851
W WKK ++ + S ++ V + +TAG +H+KFW A L+
Sbjct: 163 WAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLL 220
Query: 852 GRKGYIGTLGKN-DTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLV-KTVKAHDGPVFSM 909
GR G +G L N T + G + F TS+G +C + D L+ K V+ +
Sbjct: 221 GRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHCI 280
Query: 910 HALEKGFVTGGKDGIVALWDDSFERCLKT 938
+ G DG V L++ S L T
Sbjct: 281 SVSQDYIFCGCADGTVRLFNPSNLHFLST 309
Score = 77.8 bits (190), Expect = 1e-13
Identities = 88/341 (25%), Positives = 146/341 (42%), Gaps = 55/341 (16%)
Query: 36 IVYFVAGVGVVYSPREHRQKFYRGHS-DDIISLALHPERVLVATGQVGKEPYICIWDSYT 94
+ Y V V+++PR+H+Q S I +LA P+ + TG+ G P + +WD
Sbjct: 64 VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
Query: 95 VQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIF 154
++ L++ H +G+AC+AF + +VSVG V VW WK+ +++ + + R+
Sbjct: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVA-SNKVSSRVT 181
Query: 155 DISWDLYQPNKLVSCGVKHIKFWSLCG------NALTPKRGVFGKTGDLQTILC--LACA 206
+S+ + V+ G +HIKFW L NA P G G G+L+ L +AC
Sbjct: 182 AVSFS-EDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
Query: 207 RDE-------LTYSGAL---NGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRD 256
R + +T SG L + + K + L T+ AH ++ ++ G D
Sbjct: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRTTV--AHC-----ISVSQDYIFCGCAD 293
Query: 257 GCIRLWDLTFKPITVIDLRETDQGYK-GLSVRSVCWRGDHILVGTQDSEIFEIVVQERNK 315
G +RL F P + L + + G + SV T+ S +F V R
Sbjct: 294 GTVRL----FNPSNLHFLSTLPRPHALGTDIASV----------TEASRLFSGVANARYP 339
Query: 316 PFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356
+ AL PT +D S+ +W + D
Sbjct: 340 DTI-----------ALTFDPTNQWLSCVYNDHSIYVWDVRD 369
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 14/160 (8%)
Query: 1452 SATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEG 1511
S P++ +WD ++ L+ H GV V+FS + K ++SVG + + +W W++
Sbjct: 110 SGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKN 168
Query: 1512 AKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL---------AGRALLSKKGLL 1562
+AS + R+ F D + FV+ G +H+KFW L A LL + GLL
Sbjct: 169 IVVASNK-VSSRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLL 226
Query: 1563 STLEDARMQTMLAIAFGAN-NLTFTGTISGDVCVWKDHIL 1601
L + + T +A G + TF T SG +C + D L
Sbjct: 227 GELRN-NLFTDVACGRGKKADSTFCITSSGLLCEFSDRRL 265
Score = 47.8 bits (112), Expect = 1e-04
Identities = 76/346 (21%), Positives = 138/346 (39%), Gaps = 59/346 (17%)
Query: 369 IRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGT---YLAV 425
IR V+ +G HLA G + G+ V ++ ++E++ ++ I L+YS T LA
Sbjct: 476 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 535
Query: 426 GCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWS-SDSRYLQTNDGNGKRLFYRMPGGK 484
D + + + Y S IT + ++ SD + + G K +++R K
Sbjct: 536 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRT-AQK 594
Query: 485 EVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDIN---------DINS------------ 523
+ + H T + ++V W KY+ I +I+S
Sbjct: 595 SGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISSGKQKKLFKGSQG 653
Query: 524 VDGNYI-------GQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQ 576
DG I G + T+ + +F + G GHS VT +++S+D +
Sbjct: 654 EDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS---SGECVATMFGHSEIVTGMKFSNDCK 710
Query: 577 WVISIGGADHSVFQWKFIPERKLKDAVHIA----------------PQESLADSHSDESD 620
+IS+ G D +F W+ E + +A PQ + + + ++
Sbjct: 711 HLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRA-SGPNRHQAP 768
Query: 621 SDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATS 666
S LS P L S+ ++E + + +E+LP L K +K+ S
Sbjct: 769 SMLSPGPALSSDSDKEGE----DEGTEEELPALPVLAKSTKKALAS 810
Score = 42.4 bits (98), Expect = 0.005
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Query: 1908 SGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSL 1967
SGI + T + +FDF E A GHS VT ++F++ +H++S GD C +
Sbjct: 666 SGIYIATSCSDKNLSIFDFSSGECVAT---MFGHSEIVTGMKFSNDCKHLISVSGDSC-I 721
Query: 1968 FVWK 1971
FVW+
Sbjct: 722 FVWR 725
Score = 32.3 bits (72), Expect = 4.7
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 726 HDDDILCLTIH-PLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSA-D 783
HD +ILCL P RD IH+ D L H ++AV F+A D
Sbjct: 514 HDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASD 573
Query: 784 GK-RLASVGIDDS 795
G+ R+ S G D S
Sbjct: 574 GQVRMISCGADKS 586
Score = 32.0 bits (71), Expect = 6.2
Identities = 37/149 (24%), Positives = 57/149 (38%), Gaps = 16/149 (10%)
Query: 1061 DGSFLMANADTLEDLVSF---HH--RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS 1115
D S A D V F HH RK + D+ P S KY A+ D I I+N+ S
Sbjct: 584 DKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEP-SWKYTAIGCQDRNIRIFNISSG 642
Query: 1116 KRVGICKGA---TSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAW 1172
K+ + KG+ + + D G + + K F+ G+ E +
Sbjct: 643 KQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTG 702
Query: 1173 ASWT-------SVLGLCCEGIWPVIGEVT 1194
++ SV G C +W + E+T
Sbjct: 703 MKFSNDCKHLISVSGDSCIFVWRLSSEMT 731
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 80.5 bits (197), Expect = 2e-14
Identities = 98/391 (25%), Positives = 166/391 (42%), Gaps = 33/391 (8%)
Query: 59 GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
GHS+ +IS+A P +A+G + + WD T K H H + +++ DG
Sbjct: 112 GHSEAVISVAFSPTGKYLASGS--GDTTVRFWDLSTETPHFTCKG-HRHWVLSISWSPDG 168
Query: 119 QRLVSVGLDSKNA-VCVWDWKRGKMLSMA-PGHTDRIFDISWDLYQPN---KLVSCGVKH 173
++L S KN + +WD GK + GH+ I +SW+ N + V+ K
Sbjct: 169 RKLAS---GCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 174 --IKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGIN--LI 229
++ W T R TG Q++ CL D L YS + + I VW+ + L
Sbjct: 226 GSVRIWDT-----TAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 230 RTIQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSV-RS 288
RT+QG H + +M A +A R G + + P DL+ + Q K ++ R
Sbjct: 281 RTLQG-HGHWVNTM-ALSTDYAL--RTGAFEPAEASVNPQ---DLQGSLQELKERALSRY 333
Query: 289 VCWRG---DHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSD 345
RG + ++ G+ D +F E KP M GH + + + P + + S
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-QALINQVLFSPDSRIVASASF 392
Query: 346 DRSVRIWSLVDHALIARCNME-EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHI 404
D+S+++W +A + A +AD L G D + V V+ + +
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 405 KDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
+ ++ + +SPDG +A G D + I+
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 53.1 bits (126), Expect = 3e-06
Identities = 97/441 (21%), Positives = 167/441 (37%), Gaps = 90/441 (20%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADG 784
GH + ++ + P Y+A+G D ++ WD T P KGH + V ++ +S DG
Sbjct: 112 GHSEAVISVAFSPTGKYLASGS--GDTTVRFWDLSTETPHFTCKGHRHW-VLSISWSPDG 168
Query: 785 KRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFV------VKMNPYVPDKLITAGIK 838
++LAS G + ++LWD G+++ K + NP ++
Sbjct: 169 RKLAS-GCKNGQ-ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 839 HMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWR--DIFLV 896
++ W GR I T G ++ C +G + + +S + + +WR D L
Sbjct: 227 SVRIWDTTA----GRCERILT-GHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 897 KTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLE 956
+T++ H V +M AL D YA++ A P + +
Sbjct: 281 RTLQGHGHWVNTM----------------ALSTD--------YALRTGAFEPAEASVNPQ 316
Query: 957 D----NPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPI 1012
D ++ +L +++ G GP LV G
Sbjct: 317 DLQGSLQELKERALSRYNLVRG-----------QGP-ERLVSG----------------- 347
Query: 1013 CATVSDDKTLRIW----DLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMAN 1068
SDD TL +W D P M + L FSPD + +A D S + +
Sbjct: 348 ----SDDFTLFLWSPAEDKKPLTRMTGHQALINQ---VLFSPDSRIVASASFDKSIKLWD 400
Query: 1069 ADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYI 1128
T + L S + I +S S + L S DS + +++V + K G +
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADS-RLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459
Query: 1129 THIDWDIRGKLLQVNTGAKEQ 1149
+DW G+ +V +G K++
Sbjct: 460 YAVDWSPDGQ--RVASGGKDK 478
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 16/136 (11%)
Query: 1693 CNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIA-DKKMLNKVNLGHAARTVCY 1751
C + GH + I +A P+ + S + D TVR WD++ + H ++ +
Sbjct: 106 CTSSLEGHSEAVI-SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 1752 SPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHD----------IRFSPDSRYLA 1801
SP+G +A G KNG+ ++ S+ GK+ R A H + +P+ RY+A
Sbjct: 165 SPDGRKLASGCKNGQILLWDPST----GKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 1802 VGSSENSVDFYDLTLG 1817
S + SV +D T G
Sbjct: 221 SSSKDGSVRIWDTTAG 236
Score = 50.4 bits (119), Expect = 2e-05
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 46 VYSPREHRQKFYR--GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKD 103
++SP E ++ R GH I + P+ +VA+ K I +WD T + ++ L+
Sbjct: 355 LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS--IKLWDGRTGKYLASLRG 412
Query: 104 VHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISW 158
H + +A+ D + LVS DS + VWD K K+ PGH D ++ + W
Sbjct: 413 -HVAAVYQIAWSADSRLLVSGSSDS--TLKVWDVKAQKLAMDLPGHADEVYAVDW 464
Score = 48.1 bits (113), Expect = 8e-05
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 392 VLRVRDMTEVVH-IKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECLGS 450
+ RVR +T ++ EA+ + +SP G YLA G D++V + ++ C G
Sbjct: 97 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHF-TCKGH 155
Query: 451 LSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKEVTST-----EEIKGVHW 497
++ + WS D R L + NG+ L + GK+V T + I G+ W
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSW 207
Score = 46.6 bits (109), Expect = 2e-04
Identities = 82/387 (21%), Positives = 143/387 (36%), Gaps = 61/387 (15%)
Query: 144 SMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCL 203
S GH++ + +++ G ++FW L + TP F G +L +
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL--STETPH---FTCKGHRHWVLSI 162
Query: 204 ACARD-ELTYSGALNGDIYVWK---GINLIRTIQGAHAAGIFSMN--------ACEEGFA 251
+ + D SG NG I +W G + RT+ G H+ I ++ C A
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAG-HSKWITGLSWEPLHANPECRY-VA 220
Query: 252 TGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQ 311
+ +DG +R+WD T I T SV + W GD +L ++
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQ------SVTCLRWGGDGLLYSASQDRTIKVWRA 274
Query: 312 ERNKPFLIMQGHCE-------GELWALAVHPTKPL-AVTGSDDRSVRIWSLVDHALIARC 363
+QGH +AL +P A D + L + AL +R
Sbjct: 275 HDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL-SRY 333
Query: 364 NMEEPIRCAAVNADGIHLALGMKDGSFTVLR---VRDMTEVVHIKDRKEAIHELKYSPDG 420
N+ V G + D FT+ D + + + I+++ +SPD
Sbjct: 334 NL--------VRGQGPERLVSGSD-DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS 384
Query: 421 TYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTN---------DG 471
+A D S+ ++ + K + G ++ + + WS+DSR L + D
Sbjct: 385 RIVASASFDKSIKLWD-GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 472 NGKRLFYRMPGGKEVTSTEEIKGVHWA 498
++L +PG +E+ V W+
Sbjct: 444 KAQKLAMDLPG-----HADEVYAVDWS 465
Score = 45.8 bits (107), Expect = 4e-04
Identities = 39/155 (25%), Positives = 68/155 (43%), Gaps = 6/155 (3%)
Query: 990 TLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFS 1049
T ++GH E + +A P A+ S D T+R WDLS + + +S
Sbjct: 107 TSSLEGHSEAVI-SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 1050 PDGKALAVGLNDGSFLMANADTLEDL-VSFHHRKDMISDIRFSP----GSGKYLAVASHD 1104
PDG+ LA G +G L+ + T + + + I+ + + P +Y+A +S D
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 1105 SFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKL 1139
+ I++ + + I G T +T + W G L
Sbjct: 226 GSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLL 260
Score = 42.4 bits (98), Expect = 0.005
Identities = 104/449 (23%), Positives = 160/449 (35%), Gaps = 107/449 (23%)
Query: 1476 HSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDT 1535
HS+ V SV+FS TGK L S D T+ W + GH + + PD
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDT--TVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 1536 QFVSVGVKHVKFWTLA-----GRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTIS 1590
+ W + GR L ++ L + + A++ +
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASS-----SKD 225
Query: 1591 GDVCVWKDHI-LCRIVARAHNGPVFAMYTTLR---DGLIVTGGKERPSK-----EGGAVK 1641
G V +W C + H V T LR DGL+ + ++R K +G +
Sbjct: 226 GSVRIWDTTAGRCERILTGHTQSV----TCLRWGGDGLLYSASQDRTIKVWRAHDGVLCR 281
Query: 1642 L------WDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNI 1695
W + + L TG SV + L G+ + E+ E+ +
Sbjct: 282 TLQGHGHWVNTMALSTDYALRTGAFEPAEASV---NPQDLQGS----LQELKERALSRYN 334
Query: 1696 LVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIA-DKKMLNKVNLGHAARTVCYSPE 1754
LV G GP + +S ++D T+ LW A DKK L ++ GH A
Sbjct: 335 LVRGQ--GP----------ERLVSGSDDFTLFLWSPAEDKKPLTRMT-GHQA-------- 373
Query: 1755 GDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDL 1814
I+ + FSPDSR +A S + S+ +D
Sbjct: 374 --------------------------------LINQVLFSPDSRIVASASFDKSIKLWD- 400
Query: 1815 TLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMD---HAAI 1871
G T ++ + + V Q+ +SADS L S V++V + K MD HA
Sbjct: 401 --GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA-- 456
Query: 1872 DRITWATWT-------SILGDEVLGIWSR 1893
D + W+ S D+ L IW R
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 42.0 bits (97), Expect = 0.006
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 367 EPIRCAAVNADGIHLALGMKDGSFTVLRVRDM-TEVVHI--KDRKEAIHELKYSPDGTYL 423
E + A + G +LA G D T +R D+ TE H K + + + +SPDG L
Sbjct: 115 EAVISVAFSPTGKYLASGSGD---TTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 424 AVGCNDSSVDIYGVAQRYKKVGECL-GSLSFITHLDW-----SSDSRYLQTNDGNGKRLF 477
A GC + + ++ + K+VG L G +IT L W + + RY+ ++ +G
Sbjct: 172 ASGCKNGQILLWDPSTG-KQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 478 YRMPGGKEVTSTEEIKGVHWASWTCV 503
+ G+ E I H S TC+
Sbjct: 231 WDTTAGR----CERILTGHTQSVTCL 252
Score = 41.6 bits (96), Expect = 0.008
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
Query: 750 DPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKL 809
D SI +WD T K L+ L+G H V + +SAD + L S G DS T+ +WD K +
Sbjct: 393 DKSIKLWDGRTGKYLASLRG-HVAAVYQIAWSADSRLLVS-GSSDS-TLKVWDVKAQKLA 449
Query: 810 SIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRK 845
G D+++ V +P K ++ WR+
Sbjct: 450 MDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 38.1 bits (87), Expect = 0.086
Identities = 50/188 (26%), Positives = 85/188 (45%), Gaps = 33/188 (17%)
Query: 1787 AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQ 1846
A+ + FSP +YLA GS + +V F+DL+ T CK +V+ + +S D +
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLS---TETPHFTCKGHRHWVLSISWSPDGR--K 170
Query: 1847 VSSGCYKRHV--YEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCAC 1904
++SGC + ++ +GK + A + W + L E L A+ C
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLA----GHSKWITGLSWEPL--------HANPECRY 218
Query: 1905 VSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFL-GHSPHVTNIRFTSGDRHVVSAGGD 1963
V+ S G V+++D + +R L GH+ VT +R+ GD + SA
Sbjct: 219 VASSSKD-------GSVRIWDTTA----GRCERILTGHTQSVTCLRW-GGDGLLYSA-SQ 265
Query: 1964 DCSLFVWK 1971
D ++ VW+
Sbjct: 266 DRTIKVWR 273
Score = 36.2 bits (82), Expect = 0.33
Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 1/83 (1%)
Query: 1077 SFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIR 1136
S + + + FSP +GKYLA S D+ + +++ + CKG ++ I W
Sbjct: 109 SLEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Query: 1137 GKLLQVNTGAKEQLFFEAPRGKK 1159
G+ L + L ++ GK+
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQ 190
Score = 35.0 bits (79), Expect = 0.73
Identities = 23/92 (25%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1457 SIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS 1516
SI +WD + L+ LR H V +++SA +LL+S D T+ +W +
Sbjct: 395 SIKLWDGRTGKYLASLRG-HVAAVYQIAWSADSRLLVSGSSDS--TLKVWDVKAQKLAMD 451
Query: 1517 RAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW 1548
GH ++ ++ PD K ++ W
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 79.7 bits (195), Expect = 3e-14
Identities = 64/222 (28%), Positives = 99/222 (44%), Gaps = 19/222 (8%)
Query: 682 VHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHD-DDILCLTIHPLKD 740
V G RG C + G + Y V V++N +++ Q L I L P
Sbjct: 49 VSGGRGLACDP-----RSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 741 YVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVL 800
Y+ TG+ G P++ +WD ++ L+ H+YGV+ V FS K + SVG V +
Sbjct: 104 YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
Query: 801 WDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWR---------KAGGGLI 851
W WKK ++ + S ++ V + +TAG +H+KFW A L+
Sbjct: 163 WAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLL 220
Query: 852 GRKGYIGTLGKN-DTMMCAVYGWTEEMAFSGTSTGDVCIWRD 892
GR G +G L N T + G + F TS+G +C + D
Sbjct: 221 GRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSD 262
Score = 77.8 bits (190), Expect = 1e-13
Identities = 87/341 (25%), Positives = 144/341 (42%), Gaps = 49/341 (14%)
Query: 36 IVYFVAGVGVVYSPREHRQKFYRGHS-DDIISLALHPERVLVATGQVGKEPYICIWDSYT 94
+ Y V V+++PR+H+Q S I +LA P+ + TG+ G P + +WD
Sbjct: 64 VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
Query: 95 VQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIF 154
++ L++ H +G+AC+AF + +VSVG V VW WK+ +++ + + R+
Sbjct: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVA-SNKVSSRVT 181
Query: 155 DISWDLYQPNKLVSCGVKHIKFWSLCG------NALTPKRGVFGKTGDLQTILC--LACA 206
+S+ + V+ G +HIKFW L NA P G G G+L+ L +AC
Sbjct: 182 AVSFS-EDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
Query: 207 RDE-------LTYSGAL---NGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRD 256
R + +T SG L + + K + L R I ++ ++ G D
Sbjct: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVEL-RNIDSFTTTVAHCISVSQDYIFCGCAD 299
Query: 257 GCIRLWDLTFKPITVIDLRETDQGYK-GLSVRSVCWRGDHILVGTQDSEIFEIVVQERNK 315
G +RL F P + L + + G + SV T+ S +F V R
Sbjct: 300 GTVRL----FNPSNLHFLSTLPRPHALGTDIASV----------TEASRLFSGVANARYP 345
Query: 316 PFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356
+ AL PT +D S+ +W + D
Sbjct: 346 DTI-----------ALTFDPTNQWLSCVYNDHSIYVWDVRD 375
Score = 67.8 bits (164), Expect = 1e-10
Identities = 101/479 (21%), Positives = 184/479 (38%), Gaps = 82/479 (17%)
Query: 1452 SATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEG 1511
S P++ +WD ++ L+ H GV V+FS + K ++SVG + + +W W++
Sbjct: 110 SGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKN 168
Query: 1512 AKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL---------AGRALLSKKGLL 1562
+AS + R+ F D + FV+ G +H+KFW L A LL + GLL
Sbjct: 169 IVVASNK-VSSRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLL 226
Query: 1563 STLEDARMQTMLAIAFGAN-NLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLR 1621
L + + T +A G + TF T SG +C + D L N + + TT+
Sbjct: 227 GELRN-NLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRN--IDSFTTTVA 283
Query: 1622 DGLIVTGGKERPSKEGGAVKLWD-------QELRRCRAFRLETGQATDCVRSVCRGKGKI 1674
+ V+ G V+L++ L R A + T+ R +
Sbjct: 284 HCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASR--------L 335
Query: 1675 LVGTRNAE-----IIEVGEKNAACNILVNGH------VDGP---------------IWGL 1708
G NA + N + + N H V P +W +
Sbjct: 336 FSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSV 395
Query: 1709 ATHPS----------RDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMV 1758
+P F++ + D T+RLW+ + H + D++
Sbjct: 396 EVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGV-------HGSTLHRNILSSDLI 448
Query: 1759 AIGMKNGEFIILLVSSL----KIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDL 1814
I +G LL + L K D R I + SP+ ++LA G ++ ++L
Sbjct: 449 KIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL 508
Query: 1815 TLGPTLNRISYCKDIPSFVIQMDFS-ADSSYLQVSSGCYKRHVYEVPSGKHLMDHAAID 1872
+L+ + + S ++ +++S D+ ++S R ++ + +G+ +D
Sbjct: 509 ---QSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD 564
Score = 47.8 bits (112), Expect = 1e-04
Identities = 76/346 (21%), Positives = 138/346 (39%), Gaps = 59/346 (17%)
Query: 369 IRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGT---YLAV 425
IR V+ +G HLA G + G+ V ++ ++E++ ++ I L+YS T LA
Sbjct: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
Query: 426 GCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWS-SDSRYLQTNDGNGKRLFYRMPGGK 484
D + + + Y S IT + ++ SD + + G K +++R K
Sbjct: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRT-AQK 600
Query: 485 EVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDIN---------DINS------------ 523
+ + H T + ++V W KY+ I +I+S
Sbjct: 601 SGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISSGKQKKLFKGSQG 659
Query: 524 VDGNYI-------GQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQ 576
DG I G + T+ + +F + G GHS VT +++S+D +
Sbjct: 660 EDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS---SGECVATMFGHSEIVTGMKFSNDCK 716
Query: 577 WVISIGGADHSVFQWKFIPERKLKDAVHIA----------------PQESLADSHSDESD 620
+IS+ G D +F W+ E + +A PQ + + + ++
Sbjct: 717 HLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRA-SGPNRHQAP 774
Query: 621 SDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATS 666
S LS P L S+ ++E + + +E+LP L K +K+ S
Sbjct: 775 SMLSPGPALSSDSDKEGE----DEGTEEELPALPVLAKSTKKALAS 816
Score = 42.4 bits (98), Expect = 0.005
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Query: 1908 SGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSL 1967
SGI + T + +FDF E A GHS VT ++F++ +H++S GD C +
Sbjct: 672 SGIYIATSCSDKNLSIFDFSSGECVAT---MFGHSEIVTGMKFSNDCKHLISVSGDSC-I 727
Query: 1968 FVWK 1971
FVW+
Sbjct: 728 FVWR 731
Score = 32.3 bits (72), Expect = 4.7
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 726 HDDDILCLTIH-PLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSA-D 783
HD +ILCL P RD IH+ D L H ++AV F+A D
Sbjct: 520 HDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASD 579
Query: 784 GK-RLASVGIDDS 795
G+ R+ S G D S
Sbjct: 580 GQVRMISCGADKS 592
Score = 32.0 bits (71), Expect = 6.2
Identities = 37/149 (24%), Positives = 57/149 (38%), Gaps = 16/149 (10%)
Query: 1061 DGSFLMANADTLEDLVSF---HH--RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS 1115
D S A D V F HH RK + D+ P S KY A+ D I I+N+ S
Sbjct: 590 DKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEP-SWKYTAIGCQDRNIRIFNISSG 648
Query: 1116 KRVGICKGA---TSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAW 1172
K+ + KG+ + + D G + + K F+ G+ E +
Sbjct: 649 KQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTG 708
Query: 1173 ASWT-------SVLGLCCEGIWPVIGEVT 1194
++ SV G C +W + E+T
Sbjct: 709 MKFSNDCKHLISVSGDSCIFVWRLSSEMT 737
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 77.0 bits (188), Expect = 2e-13
Identities = 130/632 (20%), Positives = 250/632 (39%), Gaps = 68/632 (10%)
Query: 6 APSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDII 65
A L L+ V G+ GH + + ++Y + ++ + Q F +GH +++
Sbjct: 9 AQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVS 68
Query: 66 SLALHPERVLVATGQV---GKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
LA+ +A+GQV G + I +WD Y + + +H I LAF + LV
Sbjct: 69 CLAISRSGEYIASGQVTFMGFKADIILWD-YKNRELLARLSLHKGKIEALAFSPNDLYLV 127
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPG---HTDRIFDISWDLYQPNKLVSCGVKHIKFWSL 179
S+G +V VW + + +P + ++ + + ++ G I+ W L
Sbjct: 128 SLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL 187
Query: 180 CGNALTPKRGVFG---KTGDLQTILCLACARDE--LTYSGALNGDIYVWKGINLIRTIQG 234
P R ++ +TG L+ I+ D+ Y G GDI + T G
Sbjct: 188 D----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVG 243
Query: 235 ----AHAAGIFSMNACEEGFATGGRDGCIRLWDLT--FKPITVIDLRETDQGYKGLSVRS 288
+ G+ ++ + G G + ++ + +KPI I L QG G++ +
Sbjct: 244 PAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQL----QG--GITSIT 297
Query: 289 VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRS 348
+ G LVGT++S I+ + + K LI H + + T L T + +
Sbjct: 298 LRGEGHQFLVGTEESHIYRVSFTD-FKETLIATCHFDAVEDIVFPFGTAELFATCA-KKD 355
Query: 349 VRIWSLVDHALIARCNMEEPIRCAAVN--ADGIHLALGMKDGSFTVLRVRDMTEVVHIKD 406
+R+W + + R + + C ++ DG + DG + I +
Sbjct: 356 IRVWHTSSNRELLRITVPN-MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINN 414
Query: 407 -RKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECL----GSLSFITHLDWSS 461
+ + + + D + G + V ++ + + +K+ E L S+S I + ++
Sbjct: 415 AHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCI-RVKRNN 473
Query: 462 DSRYLQTNDGN----------------GKRLF----YRMPGGKEVTSTEEIKGVHWASWT 501
+ + DG LF Y + +TS + K +W +
Sbjct: 474 EECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFD 533
Query: 502 CVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIG 561
E+ G S IN +D G VT + ++K++ Y +G +G
Sbjct: 534 GTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVKVWDY---NEGEVTHVGVG 585
Query: 562 HSAHVTNVRWSHDYQWVISIGGADHSVFQWKF 593
HS ++T +R S Q+++S+ AD ++ +WK+
Sbjct: 586 HSGNITRIRISPGNQYIVSV-SADGAILRWKY 616
Score = 61.6 bits (148), Expect = 7e-09
Identities = 129/667 (19%), Positives = 249/667 (37%), Gaps = 117/667 (17%)
Query: 1368 IEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILC 1427
+ +L L+ + G+ G + D + +IY ++ + T Q+F Q H +++ C
Sbjct: 11 VAELELDAVIGFNGH-VPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSC 69
Query: 1428 LTVNQHPKFINIVATGQV---GDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVS 1484
L +++ ++I A+GQV G AD I +WD N++ L+ L + K + +++
Sbjct: 70 LAISRSGEYI---ASGQVTFMGFKAD-------IILWDYKNRELLARLSLHKGK-IEALA 118
Query: 1485 FSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAE---FRPDSDTQFVSVG 1541
FS L+S+G + ++ +W + I + A F D F++ G
Sbjct: 119 FSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAG 178
Query: 1542 VKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGA---NNLTFTGTISGDVCVWKD 1598
++ W L L + + T + ++ G ++ + GT +GD+
Sbjct: 179 NGTIRVWELD----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNP 234
Query: 1599 HI-LCRIVARAHNG---PVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFR 1654
L V A + V A+ GL+V G G V + + +
Sbjct: 235 RTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSG------AGLLVFCKSPGYKPIKKIQ 288
Query: 1655 LETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACNILVNGHVD---------GP 1704
L+ G RG+G + LVGT + I V + ++ H D G
Sbjct: 289 LQGG----ITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGT 344
Query: 1705 IWGLATHPSRDF--------------------------------FLSAAEDGTVRLWDIA 1732
AT +D +SA DG +R +
Sbjct: 345 AELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPE 404
Query: 1733 DKKMLNKVNLGHAARTVCYSPEGD--MVAIGMKNGEFIILLV--SSLKIWGKKRDRRCAI 1788
+++ +N H + D V G GE + + + K+ ++ + ++
Sbjct: 405 TGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSV 464
Query: 1789 HDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVS 1848
IR ++ S++ + +DL L R + + + Q + ++
Sbjct: 465 SCIRVKRNNEECVTASTDGTCIIWDLV---RLRRNQMI--LANTLFQCVCYHPEEFQIIT 519
Query: 1849 SGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHS 1908
SG ++ Y W + + E+ G S +N ++
Sbjct: 520 SGTDRKIAY------------------WEVFDGTVIRELEGSLS-----GSINGMDITQE 556
Query: 1909 GISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLF 1968
G+ VTG + +VK++D+ E H +GHS ++T IR + G++++VS D ++
Sbjct: 557 GVHFVTGGNDHLVKVWDY--NEGEVTHVG-VGHSGNITRIRISPGNQYIVSVSADG-AIL 612
Query: 1969 VWKCVHT 1975
WK +T
Sbjct: 613 RWKYPYT 619
Score = 60.1 bits (144), Expect = 2e-08
Identities = 98/419 (23%), Positives = 162/419 (38%), Gaps = 69/419 (16%)
Query: 677 IRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIH 736
+ L V G+ G+ + ++Y + +I Q F GH +++ CL I
Sbjct: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
Query: 737 PLKDYVATGQV---GRDPSIHIWD---TETIKPLSILKGHHQYGVSAVDFSADGKRLASV 790
+Y+A+GQV G I +WD E + LS+ KG + A+ FS + L S+
Sbjct: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGK----IEALAFSPNDLYLVSL 129
Query: 791 GIDDSHTVVLWDWKKGEKL--SIARG-------------SKDKIFVVKMNPYVPDKLITA 835
G D +VV+W K + + S A G +D++F+ N + ++
Sbjct: 130 GGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTI--RVWEL 187
Query: 836 GIKHMKFW-RKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RD 892
+ + K W + G + K + ++G +D + + GT+TGD+ R
Sbjct: 188 DLPNRKIWPTECQTGQL--KRIVMSIGVDD---------DDSFFYLGTTTGDILKMNPRT 236
Query: 893 IFLVKTVKAHDGPVFSMHALE----KGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAP 948
L A D + A+ G + G G++ F + IK+ L
Sbjct: 237 KLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLV-----FCKSPGYKPIKKIQLQG 291
Query: 949 GSKGLLLEDNPSIRAISLGHGH-ILVGTKNGEILEVDKSG-PITLLVQGH---MEGEVWG 1003
G + L G GH LVGT+ I V + TL+ H +E V+
Sbjct: 292 GITSITLR----------GEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFP 341
Query: 1004 LATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDG 1062
T CA K +R+W S + +L + F DGK++ NDG
Sbjct: 342 FGTAELFATCA----KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDG 396
Score = 39.3 bits (90), Expect = 0.039
Identities = 23/95 (24%), Positives = 43/95 (45%), Gaps = 4/95 (4%)
Query: 732 CLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVG 791
C+ HP + + T G D I W+ + L+G ++ +D + +G + G
Sbjct: 507 CVCYHPEEFQIITS--GTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGG 564
Query: 792 IDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNP 826
D H V +WD+ +GE + G I ++++P
Sbjct: 565 ND--HLVKVWDYNEGEVTHVGVGHSGNITRIRISP 597
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 74.7 bits (182), Expect = 8e-13
Identities = 58/223 (26%), Positives = 97/223 (43%), Gaps = 19/223 (8%)
Query: 660 KQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNT 719
++++ S E N + L V G + G + Y V VI + ++N
Sbjct: 43 RRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENK 102
Query: 720 QRFYLGHDDDIL-CLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAV 778
Q+ L L P Y+ TG+ G P++ IWD E ++ + GH +YGV+ V
Sbjct: 103 QQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGH-KYGVACV 161
Query: 779 DFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDK--LITAG 836
FS + K + S+G + +WDWKK + +K V+ ++ + D +T G
Sbjct: 162 AFSPNMKHIVSMGYQHDMVLNVWDWKKD---IVVASNKVSCRVIALS-FSEDSSYFVTVG 217
Query: 837 IKHMKFW---------RKAGGGLIGRKGYIGTLGKNDTMMCAV 870
+H++FW + L+GR G +G L N + C V
Sbjct: 218 NRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNN--IFCGV 258
Score = 70.9 bits (172), Expect = 1e-11
Identities = 63/246 (25%), Positives = 114/246 (46%), Gaps = 29/246 (11%)
Query: 36 IVYFVAGVGVVYSPREHRQK-FYRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYT 94
+ Y V V+ P+E++Q+ + + +LA P+ + TG+ G P + IWD
Sbjct: 85 VAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEE 144
Query: 95 VQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIF 154
++ + H +G+AC+AF + + +VS+G + VWDWK+ +++ + + R+
Sbjct: 145 KNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVA-SNKVSCRVI 202
Query: 155 DISWDLYQPNKLVSCGVKHIKFWSLCGNALT------PKRGVFGKTGDL-QTILC-LACA 206
+S+ + V+ G +H++FW L + T P G G G+L I C +AC
Sbjct: 203 ALSFS-EDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACG 261
Query: 207 RDEL-------TYSGAL---NGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRD 256
R + +YSG L N + K INL ++ + +E G D
Sbjct: 262 RGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSC-------LCVSQELIFCGCTD 314
Query: 257 GCIRLW 262
G +R++
Sbjct: 315 GIVRIF 320
Score = 58.9 bits (141), Expect = 5e-08
Identities = 67/285 (23%), Positives = 115/285 (40%), Gaps = 30/285 (10%)
Query: 1327 QKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLV-LELIFGYRGRDCR 1385
+K PS+ RG P APP + +T + +++ V LE + G ++
Sbjct: 16 EKLPSVMAGVPARRGQSSPPP-APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSS 74
Query: 1386 NNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQV 1445
G V IL Q + + L + K+I TG+
Sbjct: 75 GLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYI---VTGEN 131
Query: 1446 GDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITI 1505
G P++ IWD K ++ + H GV V+FS K ++S+G + + +
Sbjct: 132 GHR-------PAVRIWDVEEKNQVAEM-LGHKYGVACVAFSPNMKHIVSMGYQHDMVLNV 183
Query: 1506 WRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL---------AGRALL 1556
W W++ +AS + R+ F DS + FV+VG +HV+FW L + L+
Sbjct: 184 WDWKKDIVVASNK-VSCRVIALSFSEDS-SYFVTVGNRHVRFWFLEVSTETKVTSTVPLV 241
Query: 1557 SKKGLLSTLEDARMQTMLAIAFGANNL---TFTGTISGDVCVWKD 1598
+ G+L L + +A G + TF + SG +C + +
Sbjct: 242 GRSGILGELHN---NIFCGVACGRGRMAGSTFCVSYSGLLCQFNE 283
Score = 48.9 bits (115), Expect = 5e-05
Identities = 70/340 (20%), Positives = 135/340 (39%), Gaps = 47/340 (13%)
Query: 369 IRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG---TYLAV 425
+R V+ DG HLA G + G+ + + M E+V ++ + L+YS T LA
Sbjct: 495 VRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLAS 554
Query: 426 GCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKE 485
D + + V + Y S IT + ++ + + G K +++R +
Sbjct: 555 ASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFR-SAQQG 613
Query: 486 VTSTEEIKGVHWASWTCVSGLEVNGIWPKY-------SDINDINSVDGN----YIGQVLV 534
++ H A T + ++++ I KY ++ N+V+G Y G
Sbjct: 614 SDGLHFVRTHHVAEKTTLYDMDID-ITQKYVAVACQDRNVRVYNTVNGKQKKCYKGS--- 669
Query: 535 TADDYGIIKLFRYP--------CLRK---------GAKFRKYIGHSAHVTNVRWSHDYQW 577
D+ ++K+ P C K G K GHS +T++++++D
Sbjct: 670 QGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHH 729
Query: 578 VISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDE----SDSDLSDVPELDSEI 633
+I++ G D VF W PE + Q L H + +D S P D+ +
Sbjct: 730 LITVSG-DSCVFIWHLGPE-----ITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYV 783
Query: 634 EQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSKRRERAP 673
+++ + ++ L+E+C+ ++ T + P
Sbjct: 784 STPSEI-HSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDP 822
Score = 39.3 bits (90), Expect = 0.039
Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 1905 VSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDD 1964
V SG L T + + DF E AK GHS +T+++FT H+++ GD
Sbjct: 681 VDPSGTFLATSCSDKSISVIDFYSGECIAK---MFGHSEIITSMKFTYDCHHLITVSGDS 737
Query: 1965 CSLFVW 1970
C +F+W
Sbjct: 738 C-VFIW 742
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 74.7 bits (182), Expect = 8e-13
Identities = 58/223 (26%), Positives = 97/223 (43%), Gaps = 19/223 (8%)
Query: 660 KQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNT 719
++++ S E N + L V G + G + Y V VI + ++N
Sbjct: 43 RRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENK 102
Query: 720 QRFYLGHDDDIL-CLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAV 778
Q+ L L P Y+ TG+ G P++ IWD E ++ + GH +YGV+ V
Sbjct: 103 QQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGH-KYGVACV 161
Query: 779 DFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDK--LITAG 836
FS + K + S+G + +WDWKK + +K V+ ++ + D +T G
Sbjct: 162 AFSPNMKHIVSMGYQHDMVLNVWDWKKD---IVVASNKVSCRVIALS-FSEDSSYFVTVG 217
Query: 837 IKHMKFW---------RKAGGGLIGRKGYIGTLGKNDTMMCAV 870
+H++FW + L+GR G +G L N + C V
Sbjct: 218 NRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNN--IFCGV 258
Score = 70.9 bits (172), Expect = 1e-11
Identities = 63/246 (25%), Positives = 114/246 (46%), Gaps = 29/246 (11%)
Query: 36 IVYFVAGVGVVYSPREHRQK-FYRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYT 94
+ Y V V+ P+E++Q+ + + +LA P+ + TG+ G P + IWD
Sbjct: 85 VAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEE 144
Query: 95 VQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIF 154
++ + H +G+AC+AF + + +VS+G + VWDWK+ +++ + + R+
Sbjct: 145 KNQVAEMLG-HKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVA-SNKVSCRVI 202
Query: 155 DISWDLYQPNKLVSCGVKHIKFWSLCGNALT------PKRGVFGKTGDL-QTILC-LACA 206
+S+ + V+ G +H++FW L + T P G G G+L I C +AC
Sbjct: 203 ALSFS-EDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACG 261
Query: 207 RDEL-------TYSGAL---NGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRD 256
R + +YSG L N + K INL ++ + +E G D
Sbjct: 262 RGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSC-------LCVSQELIFCGCTD 314
Query: 257 GCIRLW 262
G +R++
Sbjct: 315 GIVRIF 320
Score = 58.9 bits (141), Expect = 5e-08
Identities = 67/285 (23%), Positives = 115/285 (40%), Gaps = 30/285 (10%)
Query: 1327 QKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLV-LELIFGYRGRDCR 1385
+K PS+ RG P APP + +T + +++ V LE + G ++
Sbjct: 16 EKLPSVMAGVPARRGQSSPPP-APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSS 74
Query: 1386 NNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQV 1445
G V IL Q + + L + K+I TG+
Sbjct: 75 GLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYI---VTGEN 131
Query: 1446 GDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITI 1505
G P++ IWD K ++ + H GV V+FS K ++S+G + + +
Sbjct: 132 GHR-------PAVRIWDVEEKNQVAEM-LGHKYGVACVAFSPNMKHIVSMGYQHDMVLNV 183
Query: 1506 WRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL---------AGRALL 1556
W W++ +AS + R+ F DS + FV+VG +HV+FW L + L+
Sbjct: 184 WDWKKDIVVASNK-VSCRVIALSFSEDS-SYFVTVGNRHVRFWFLEVSTETKVTSTVPLV 241
Query: 1557 SKKGLLSTLEDARMQTMLAIAFGANNL---TFTGTISGDVCVWKD 1598
+ G+L L + +A G + TF + SG +C + +
Sbjct: 242 GRSGILGELHN---NIFCGVACGRGRMAGSTFCVSYSGLLCQFNE 283
Score = 48.9 bits (115), Expect = 5e-05
Identities = 70/340 (20%), Positives = 135/340 (39%), Gaps = 47/340 (13%)
Query: 369 IRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDG---TYLAV 425
+R V+ DG HLA G + G+ + + M E+V ++ + L+YS T LA
Sbjct: 495 VRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLAS 554
Query: 426 GCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKE 485
D + + V + Y S IT + ++ + + G K +++R +
Sbjct: 555 ASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFR-SAQQG 613
Query: 486 VTSTEEIKGVHWASWTCVSGLEVNGIWPKY-------SDINDINSVDGN----YIGQVLV 534
++ H A T + ++++ I KY ++ N+V+G Y G
Sbjct: 614 SDGLHFVRTHHVAEKTTLYDMDID-ITQKYVAVACQDRNVRVYNTVNGKQKKCYKGS--- 669
Query: 535 TADDYGIIKLFRYP--------CLRK---------GAKFRKYIGHSAHVTNVRWSHDYQW 577
D+ ++K+ P C K G K GHS +T++++++D
Sbjct: 670 QGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHH 729
Query: 578 VISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDE----SDSDLSDVPELDSEI 633
+I++ G D VF W PE + Q L H + +D S P D+ +
Sbjct: 730 LITVSG-DSCVFIWHLGPE-----ITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYV 783
Query: 634 EQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSKRRERAP 673
+++ + ++ L+E+C+ ++ T + P
Sbjct: 784 STPSEI-HSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDP 822
Score = 39.3 bits (90), Expect = 0.039
Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 1905 VSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDD 1964
V SG L T + + DF E AK GHS +T+++FT H+++ GD
Sbjct: 681 VDPSGTFLATSCSDKSISVIDFYSGECIAK---MFGHSEIITSMKFTYDCHHLITVSGDS 737
Query: 1965 CSLFVW 1970
C +F+W
Sbjct: 738 C-VFIW 742
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 70.5 bits (171), Expect = 2e-11
Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 14/219 (6%)
Query: 723 YLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSA 782
+ GH +I+CL+ +P VATG + D + +WD + + + L+GH +S + F+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSM--DTTAKLWDIQNGEEVYTLRGHSAEIIS-LSFNT 229
Query: 783 DGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKF 842
G R+ + D HTVV+WD G K++I G +I N L + K K
Sbjct: 230 SGDRIITGSFD--HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 843 WRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIF--LVKTVK 900
W G + G +D ++ + + +T ++ + ++ G I+ + ++
Sbjct: 288 WDATNGKCVAT-----LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE 342
Query: 901 AHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLK 937
H+G + + +G +TG D +WD +CL+
Sbjct: 343 GHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Score = 65.1 bits (157), Expect = 7e-10
Identities = 75/357 (21%), Positives = 131/357 (36%), Gaps = 68/357 (19%)
Query: 797 TVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI-KHMKFWRKAGGGLIGRKG 855
T LWD GE+L+ G ++ ++ + N DK+ T K K W G K
Sbjct: 115 TCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG-----KC 169
Query: 856 YIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTVKAHDGPVFSMHALE 913
Y G ++C + + +G+ +W ++ V T++ H + S+
Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT 229
Query: 914 KG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHI 971
G +TG D V +WD R + I +GH
Sbjct: 230 SGDRIITGSFDHTVVVWDADTGRKVN--------------------------ILIGHC-- 261
Query: 972 LVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSH 1031
EI + +L++ G M DKT ++WD +
Sbjct: 262 ------AEISSASFNWDCSLILTGSM---------------------DKTCKLWDATNGK 294
Query: 1032 CMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFS 1091
C+ + CF GK +A DG+ + +A T + + + IS I F+
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
Query: 1092 PGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLLQVNTGAKE 1148
P G +L S D I++ + + + + +G T I ++ +G + V TG+K+
Sbjct: 355 P-QGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNI--VITGSKD 408
Score = 63.2 bits (152), Expect = 2e-09
Identities = 73/298 (24%), Positives = 127/298 (42%), Gaps = 58/298 (19%)
Query: 57 YRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDL 116
+RGH+ +I+ L+ +P+ LVATG + + +WD + + L+ H+ I L+F+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSM--DTTAKLWDIQNGEEVYTLRG-HSAEIISLSFNT 229
Query: 117 DGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKF 176
G R+++ D + V VWD G+ +++ GH I S++ L K K
Sbjct: 230 SGDRIITGSFD--HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 177 WSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAH 236
W T + V TG IL +C Y+G L
Sbjct: 288 WD-----ATNGKCVATLTGHDDEILD-SC----FDYTGKL-------------------- 317
Query: 237 AAGIFSMNACEEGFATGGRDGCIRLWD-LTFKPITVIDLRETDQGYKG-LSVRSVCWRGD 294
AT DG R++ T K I + +G++G +S S +G+
Sbjct: 318 -------------IATASADGTARIFSAATRKCIAKL------EGHEGEISKISFNPQGN 358
Query: 295 HILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIW 352
H+L G+ D + I + + +++GH + E+++ A + + +TGS D + RIW
Sbjct: 359 HLLTGSSD-KTARIWDAQTGQCLQVLEGHTD-EIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 53.9 bits (128), Expect = 2e-06
Identities = 62/292 (21%), Positives = 109/292 (37%), Gaps = 42/292 (14%)
Query: 1407 LHNVATGS-QSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMN 1465
L +V TG ++ H +I+CL+ N +VATG + +A + WD N
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQS---TLVATGSMDTTAKL---------WDIQN 208
Query: 1466 KQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIF 1525
+ + LR HS + S+SF+ +G +++ D HT+ +W G K+ GH I
Sbjct: 209 GEEVYTLRG-HSAEIISLSFNTSGDRIITGSFD--HTVVVWDADTGRKVNILIGHCAEIS 265
Query: 1526 VAEFRPDSDTQFVSVGVKHVKFWTLA-GRALLSKKGLLSTLEDARMQTMLAIAFGANNLT 1584
A F D K K W G+ + + G + D+ L
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY-------TGKLI 318
Query: 1585 FTGTISGDVCVWKDHI-LCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLW 1643
T + G ++ C H G + + + ++TG ++ ++W
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK------TARIW 372
Query: 1644 DQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNI 1695
D + +C ++ G + KG I++ G K+ C I
Sbjct: 373 DAQTGQC--LQVLEGHTDEIFSCAFNYKGNIVI---------TGSKDNTCRI 413
Score = 51.6 bits (122), Expect = 8e-06
Identities = 73/360 (20%), Positives = 137/360 (38%), Gaps = 61/360 (16%)
Query: 92 SYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTD 151
++T VLK H + +A + G ++ D +WD G+ L+ GH +
Sbjct: 79 NHTFYLFKVLK-AHILPLTNVALNKSGSCFITGSYD--RTCKLWDTASGEELNTLEGHRN 135
Query: 152 RIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELT 211
++ I+++ +K+ + G F KT L ++ C T
Sbjct: 136 VVYAIAFNNPYGDKIAT--------------------GSFDKTCKLWSVETGKCYH---T 172
Query: 212 YSGALNGDIYVWKGINLIRTIQGAHAAGI--FSMNACEEGFATGGRDGCIRLWDLTFKPI 269
+ G H A I S N ATG D +LWD+
Sbjct: 173 FRG---------------------HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ-NGE 210
Query: 270 TVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELW 329
V LR LS + GD I+ G+ D + + + + I+ GHC E+
Sbjct: 211 EVYTLRGHSAEIISLSFNT---SGDRIITGSFDHTVV-VWDADTGRKVNILIGHC-AEIS 265
Query: 330 ALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPIRCAAVNADGIHLALGMKDG 388
+ + + L +TGS D++ ++W + +A ++ I + + G +A DG
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Query: 389 SFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECL 448
+ + + ++ + I ++ ++P G +L G +D + I+ + G+CL
Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA-----QTGQCL 380
Score = 47.8 bits (112), Expect = 1e-04
Identities = 56/284 (19%), Positives = 109/284 (38%), Gaps = 37/284 (13%)
Query: 986 SGPITLLVQGHMEGEVWGLA-THPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGR 1044
SG ++GH V+ +A +PY AT S DKT ++W + C R
Sbjct: 123 SGEELNTLEGH-RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIV 181
Query: 1045 CCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHD 1104
C F+P +A G D + + + E++ + I + F+ SG + S D
Sbjct: 182 CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT-SGDRIITGSFD 240
Query: 1105 SFIDIYNVMSSKRVGICKGATSYIT--HIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTI 1162
+ +++ + ++V I G + I+ +WD + TG+ ++
Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCS----LILTGSMDK------------- 283
Query: 1163 PSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRY 1222
W + G C + + G ++ SC ++AT G ++F
Sbjct: 284 --------TCKLWDATNGKC---VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
Query: 1223 PTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
T+ K + H ++ + + + L+T G +D + +W
Sbjct: 333 ATRKCIAKLE---GHEGEISKISFNPQGNHLLT-GSSDKTARIW 372
Score = 47.0 bits (110), Expect = 2e-04
Identities = 62/268 (23%), Positives = 103/268 (38%), Gaps = 23/268 (8%)
Query: 1562 LSTLEDARMQTMLAIAFGA--NNLTFTGTISGDVCVWKDHI-LCRIVARAHNGPVFAMYT 1618
L+TLE R + AIAF + TG+ +W C R H + +
Sbjct: 127 LNTLEGHR-NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSF 185
Query: 1619 TLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGT 1678
+ L+ TG + +K LWD + + L A S +I+ G+
Sbjct: 186 NPQSTLVATGSMDTTAK------LWDIQNGE-EVYTLRGHSAEIISLSFNTSGDRIITGS 238
Query: 1679 RNAEII----EVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADK 1734
+ ++ + G K NIL+ GH I + + L+ + D T +LWD +
Sbjct: 239 FDHTVVVWDADTGRK---VNILI-GHC-AEISSASFNWDCSLILTGSMDKTCKLWDATNG 293
Query: 1735 KMLNKVNLGHAARTV--CYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIR 1792
K + + GH + C+ G ++A +G I ++ K K I I
Sbjct: 294 KCVATLT-GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 1793 FSPDSRYLAVGSSENSVDFYDLTLGPTL 1820
F+P +L GSS+ + +D G L
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Score = 46.6 bits (109), Expect = 2e-04
Identities = 65/312 (20%), Positives = 120/312 (38%), Gaps = 28/312 (8%)
Query: 1460 IWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAG 1519
+WD + + L+ L H V +++F+ ++ G + T +W + G + G
Sbjct: 118 LWDTASGEELNTLEG-HRNVVYAIAFNNPYGDKIATG-SFDKTCKLWSVETGKCYHTFRG 175
Query: 1520 HNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLA-GRALLSKKGLLSTLEDARMQTMLAIAF 1578
H I F P S K W + G + + +G + + T
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT------ 229
Query: 1579 GANNLTFTGTISGDVCVWKDHILCRI-VARAHNGPVFAMYTTLRDGLIVTGGKERPSKEG 1637
+ + TG+ V VW ++ + H + + LI+TG ++
Sbjct: 230 -SGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK----- 283
Query: 1638 GAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILV---GTRNAEIIEVGEKNAACN 1694
KLWD +C A TG + + S GK++ A I + C
Sbjct: 284 -TCKLWDATNGKCVA--TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRK--CI 338
Query: 1695 ILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAAR--TVCYS 1752
+ GH +G I ++ +P + L+ + D T R+WD + L +V GH + ++
Sbjct: 339 AKLEGH-EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSCAFN 396
Query: 1753 PEGDMVAIGMKN 1764
+G++V G K+
Sbjct: 397 YKGNIVITGSKD 408
Score = 46.2 bits (108), Expect = 3e-04
Identities = 68/325 (20%), Positives = 117/325 (36%), Gaps = 38/325 (11%)
Query: 750 DPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKL 809
D + +WDT + + L+ L+GH + + G ++A+ D T LW + G+
Sbjct: 113 DRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD--KTCKLWSVETGKCY 170
Query: 810 SIARGSKDKIFVVKMNPYVPDKLITAGIKH--MKFWRKAGGGLIGRKGYIGTLGKNDTMM 867
RG +I + NP L+ G K W G + G + ++
Sbjct: 171 HTFRGHTAEIVCLSFNP--QSTLVATGSMDTTAKLWDIQNG-----EEVYTLRGHSAEII 223
Query: 868 CAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGF-----VTGGKD 922
+ + + +G+ V +W D + V G + + + +TG D
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVW-DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282
Query: 923 GIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGE--- 979
LWD + +C+ T L + I + L+ T + +
Sbjct: 283 KTCKLWDATNGKCVAT---------------LTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 980 -ILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
I I L +GH EGE+ ++ +P T S DKT RIWD C+ +
Sbjct: 328 RIFSAATRKCIAKL-EGH-EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385
Query: 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
C F+ G + G D +
Sbjct: 386 HTDEIFSCAFNYKGNIVITGSKDNT 410
Score = 43.5 bits (101), Expect = 0.002
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 7/121 (5%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADG 784
GHDD+IL +AT D + I+ T K ++ L+GH + +S + F+ G
Sbjct: 301 GHDDEILDSCFDYTGKLIATASA--DGTARIFSAATRKCIAKLEGH-EGEISKISFNPQG 357
Query: 785 KRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKH-MKFW 843
L + D T +WD + G+ L + G D+IF N Y + +IT + + W
Sbjct: 358 NHLLTGSSDK--TARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414
Query: 844 R 844
R
Sbjct: 415 R 415
Score = 43.1 bits (100), Expect = 0.003
Identities = 76/353 (21%), Positives = 136/353 (38%), Gaps = 36/353 (10%)
Query: 55 KFYRGHSDDIISLALHPERVLVATGQVGKEPYIC-IWDSYTVQTISVLKDVHTHGIACLA 113
K + H + ++AL+ TG + C +WD+ + + ++ L+ H + + +A
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRT---CKLWDTASGEELNTLEG-HRNVVYAIA 141
Query: 114 FDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKH 173
F+ ++ G K +W + GK GHT I +S++ + LV+ G
Sbjct: 142 FNNPYGDKIATGSFDKTCK-LWSVETGKCYHTFRGHTAEIVCLSFN--PQSTLVATGSMD 198
Query: 174 I--KFWSLCGNALTPKRGVFGKTGDLQTILCLAC-ARDELTYSGALNGDIYVW-----KG 225
K W + V+ G I+ L+ + +G+ + + VW +
Sbjct: 199 TTAKLWDIQNG-----EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253
Query: 226 INLIRTIQGAHAAGIFS--MNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKG 283
+N++ H A I S N TG D +LWD T D+
Sbjct: 254 VNILI----GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE---- 305
Query: 284 LSVRSVCWRGDHILVGTQDSE-IFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVT 342
+ C+ L+ T ++ I K ++GH EGE+ ++ +P +T
Sbjct: 306 --ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGH-EGEISKISFNPQGNHLLT 362
Query: 343 GSDDRSVRIW-SLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLR 394
GS D++ RIW + L + I A N G + G KD + + R
Sbjct: 363 GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 69.7 bits (169), Expect = 3e-11
Identities = 84/314 (26%), Positives = 130/314 (41%), Gaps = 37/314 (11%)
Query: 724 LGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSAD 783
+GH + + + P +++A+ R I IW K L GH+ +S V +S+D
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSADR--LIIIWGAYDGKYEKTLYGHN-LEISDVAWSSD 94
Query: 784 GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI--KHMK 841
RL S D T+ LWD + G+ L +G + +F NP P LI +G + +K
Sbjct: 95 SSRLVSAS--DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP--PSNLIISGSFDETVK 150
Query: 842 FWRKAGGGLIGRKGYIGTLGKNDTMMCAV-YGWTEEMAFSGTSTGDVCIWRDIF--LVKT 898
W G + TL + + AV + + + SG+ G IW +KT
Sbjct: 151 IWEVKTGKC------LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 899 VKAHDGPVFSMHALE---KGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLL 955
+ D P S K +T D + LWD S RCLKTY G K
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT--------GHKN--- 253
Query: 956 EDNPSIRAISLGHGHILVGTKNGEILEV--DKSGPITLLVQGHMEGEVWGLATHP--YLP 1011
E S+ G +V ++ + ++ I +QGH + V A HP L
Sbjct: 254 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD-VVISAACHPTENLI 312
Query: 1012 ICATVSDDKTLRIW 1025
A + +DKT+++W
Sbjct: 313 ASAALENDKTIKLW 326
Score = 53.1 bits (126), Expect = 3e-06
Identities = 64/277 (23%), Positives = 100/277 (36%), Gaps = 61/277 (22%)
Query: 1476 HSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDT 1535
H++ V SV FS G+ L S D I IW +G + GHN I + DS
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSAD--RLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR 97
Query: 1536 QFVSVGVKHVKFWTL-AGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVC 1594
+ K +K W + +G+ L + KG + + +NL +G+ V
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP-------PSNLIISGSFDETVK 150
Query: 1595 VWKDHI-LCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAF 1653
+W+ C AH+ PV A++ LIV+G + G ++WD +C
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD------GLCRIWDAASGQCL-- 202
Query: 1654 RLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPS 1713
K LV N P+ + P+
Sbjct: 203 -------------------KTLVDDDNP----------------------PVSFVKFSPN 221
Query: 1714 RDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC 1750
+ L+A D T++LWD + + L K GH C
Sbjct: 222 GKYILTATLDNTLKLWDYSRGRCL-KTYTGHKNEKYC 257
Score = 50.4 bits (119), Expect = 2e-05
Identities = 76/339 (22%), Positives = 130/339 (38%), Gaps = 43/339 (12%)
Query: 1407 LHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNK 1466
L + A S+ + N + C V H + ++ V G+ S+ I IW A +
Sbjct: 15 LSSSANQSKEVPENPNYALKCTLVG-HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG 73
Query: 1467 QTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFV 1526
+ L H+ + V++S+ L+S D T+ +W + G + + GH+ +F
Sbjct: 74 KYEKTLYG-HNLEISDVAWSSDSSRLVSASDDK--TLKLWDVRSGKCLKTLKGHSNYVFC 130
Query: 1527 AEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFG-ANNLTF 1585
F P S+ + VK W + K G A + A+ F + +L
Sbjct: 131 CNFNPPSNLIISGSFDETVKIWEV-------KTGKCLKTLSAHSDPVSAVHFNCSGSLIV 183
Query: 1586 TGTISGDVCVW--KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLW 1643
+G+ G +W + + N PV + + I+T + +KLW
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD------NTLKLW 237
Query: 1644 DQELRRCRAFRLETGQATD--CV---------RSVCRGKGKILVGTRNAEIIEVGEKNAA 1692
D RC + TG + C+ + + G LV N + E+ +K
Sbjct: 238 DYSRGRC--LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK--- 292
Query: 1693 CNILVNGHVDGPIWGLATHPSRDFFLSAA--EDGTVRLW 1729
+ GH D I A HP+ + SAA D T++LW
Sbjct: 293 ----LQGHTDVVI-SAACHPTENLIASAALENDKTIKLW 326
Score = 46.2 bits (108), Expect = 3e-04
Identities = 41/181 (22%), Positives = 74/181 (40%), Gaps = 16/181 (8%)
Query: 950 SKGLLLEDNPSIRAISLGHGHILVGTK---NGEILEVDKSGPITLLVQGHMEG------- 999
SK + N +++ +GH + K NGE L S +++ G +G
Sbjct: 22 SKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL-ASSSADRLIIIWGAYDGKYEKTLY 80
Query: 1000 ----EVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKAL 1055
E+ +A + SDDKTL++WD+ C+ ++ CC F+P +
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 1056 AVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS 1115
G D + + T + L + D +S + F+ SG + S+D I++ S
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN-CSGSLIVSGSYDGLCRIWDAASG 199
Query: 1116 K 1116
+
Sbjct: 200 Q 200
Score = 45.8 bits (107), Expect = 4e-04
Identities = 57/267 (21%), Positives = 100/267 (37%), Gaps = 23/267 (8%)
Query: 105 HTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPN 164
HT ++ + F +G+ L S D + +W GK GH I D++W
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSAD--RLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR 97
Query: 165 KLVSCGVKHIKFWSL-CGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW 223
+ + K +K W + G L +G C L SG+ + + +W
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKG-----HSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 224 --KGINLIRTIQGAHAAGIFSM--NACEEGFATGGRDGCIRLWDLTFKPI--TVIDLRET 277
K ++T+ AH+ + ++ N +G DG R+WD T++D
Sbjct: 153 EVKTGKCLKTL-SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 278 DQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTK 337
+ S G +IL T D+ + ++ R + GH + A
Sbjct: 212 PVSFVKFSP-----NGKYILTATLDNTL-KLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265
Query: 338 --PLAVTGSDDRSVRIWSLVDHALIAR 362
V+GS+D V IW+L ++ +
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQK 292
Score = 44.3 bits (103), Expect = 0.001
Identities = 37/171 (21%), Positives = 71/171 (41%), Gaps = 15/171 (8%)
Query: 284 LSVRSVCWRGDHI-LVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVT 342
L + V W D LV D + ++ K ++GH ++ +P L ++
Sbjct: 84 LEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH-SNYVFCCNFNPPSNLIIS 142
Query: 343 GSDDRSVRIWSLVDHALIARCNME-EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEV 401
GS D +V+IW + + + +P+ N G + G DG + R+ D
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG---LCRIWDAASG 199
Query: 402 VHIK----DRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECL 448
+K D + +K+SP+G Y+ D+++ ++ ++ G CL
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR-----GRCL 245
Score = 41.2 bits (95), Expect = 0.010
Identities = 41/176 (23%), Positives = 78/176 (44%), Gaps = 17/176 (9%)
Query: 55 KFYRGHSDDIISLALHPERVLVATGQVGKEPYIC-IWDSYTVQTISVLKDVHTHGIACLA 113
K HSD + ++ + L+ +G +C IWD+ + Q + L D ++ +
Sbjct: 161 KTLSAHSDPVSAVHFNCSGSLIVSGSYDG---LCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 114 FDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDI--SWDLYQPNKLVSCGV 171
F +G+ +++ LD N + +WD+ RG+ L GH + + I ++ + +VS
Sbjct: 218 FSPNGKYILTATLD--NTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
Query: 172 KHIKF-WSLCGNALTPKRGVFGKTGDLQTILCLAC-ARDELTYSGALNGD--IYVW 223
++ + W+L + K G ++ AC + L S AL D I +W
Sbjct: 276 DNLVYIWNLQTKEIVQK-----LQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 34.7 bits (78), Expect = 0.95
Identities = 23/112 (20%), Positives = 53/112 (47%), Gaps = 2/112 (1%)
Query: 1711 HPSRDFFLSAAEDGTVRLWDIADKKMLNKVNL-GHAARTVCYSPEGDMVAIGMKNGEFII 1769
+P + +S + D TV++W++ K L ++ V ++ G ++ G +G I
Sbjct: 134 NPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRI 193
Query: 1770 LLVSSLK-IWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTL 1820
+S + + D + ++FSP+ +Y+ + +N++ +D + G L
Sbjct: 194 WDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245
Score = 33.5 bits (75), Expect = 2.1
Identities = 51/265 (19%), Positives = 100/265 (37%), Gaps = 34/265 (12%)
Query: 898 TVKAHDGPVFSMHALEKG--FVTGGKDGIVALW---DDSFERCLKTYAIKRAALAPGSKG 952
T+ H V S+ G + D ++ +W D +E+ L + ++ + +A S
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 953 LLL---EDNPSIRAISLGHGHILVGTK--NGEILEVDKSGPITLLVQGHMEG--EVWGLA 1005
L D+ +++ + G L K + + + + P L++ G + ++W +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 1006 THPYLPICATVSD-------------------DKTLRIWDLSPSHCMLA-VRKLKKGGRC 1045
T L + SD D RIWD + C+ V
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 1046 CCFSPDGKALAVGLNDGSFLMANADTLEDLVSF--HHRKDMISDIRFSPGSGKYLAVASH 1103
FSP+GK + D + + + L ++ H + FS GK++ S
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
Query: 1104 DSFIDIYNVMSSKRVGICKGATSYI 1128
D+ + I+N+ + + V +G T +
Sbjct: 276 DNLVYIWNLQTKEIVQKLQGHTDVV 300
Score = 33.1 bits (74), Expect = 2.8
Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 409 EAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ-RYKKVGECLGSLSFITHLDWSSD-SRYL 466
EA+ +K+SP+G +LA D + I+G +Y+K G I+ + WSSD SR +
Sbjct: 42 EAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKT--LYGHNLEISDVAWSSDSSRLV 99
Query: 467 QTNDGNGKRLF 477
+D +L+
Sbjct: 100 SASDDKTLKLW 110
>gi|145279222 WD repeat domain 66 [Homo sapiens]
Length = 1149
Score = 67.4 bits (163), Expect = 1e-10
Identities = 86/454 (18%), Positives = 176/454 (38%), Gaps = 52/454 (11%)
Query: 702 IVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETI 761
++Y A +IYN +N Q GH + I CL + + ++AT G D + IWD+ T
Sbjct: 274 LLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTG 333
Query: 762 KPLSIL--KGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGE-------KLSIA 812
P+ + G+ A+ + D K LA++ + V +W W +L
Sbjct: 334 IPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTE 393
Query: 813 RGSKDKIFVVKMNPYVPDKLI----TAGIKHMKFWRK----AGGGLIGRKGYIGTLGKND 864
G ++ V NP +L+ T I + + + L+ K + +GK
Sbjct: 394 YGVQN---YVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGK-- 448
Query: 865 TMMCAVYGWTEEMAFSGTSTGDVCIW--------RDIFL-------VKTVKAHDGPVFSM 909
+++ S T G + +W FL K V + +
Sbjct: 449 -FSQSIFHLNLTQILSATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEGITVL 507
Query: 910 HALEKGFVTGGKDGIVALWDDSFE----------RCLKTYAIKRAALAPGSKGLLLEDNP 959
++ VTG G + +D + ++T + + P ++ +
Sbjct: 508 TTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPTEKSNYPPDC 567
Query: 960 SIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDD 1019
+++ + ++GT + + + G + + + ++ HPY P+ A S
Sbjct: 568 TLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSIC 627
Query: 1020 KTLRIWDLSPSHCMLA-VRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLED--LV 1076
+++W+ + + V + G + ++P+G L G +G+ + +A +LE+
Sbjct: 628 GMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPE 687
Query: 1077 SFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIY 1110
F + + ++ I FS S +Y+A A + +Y
Sbjct: 688 PFKYSRTSVTHISFSHDS-QYMATADRSFTVAVY 720
Score = 63.5 bits (153), Expect = 2e-09
Identities = 107/512 (20%), Positives = 194/512 (37%), Gaps = 88/512 (17%)
Query: 1364 KKRPIEDLVLELIFGYRGRDCRNNVHYLNDGDD--IIYHTASVGILHNVATGSQSFYQEH 1421
K P+ L + FG+ V+Y+ + ++Y A I++NV +Q Q H
Sbjct: 242 KSTPVYPLTMTWSFGWNSS---LPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGH 298
Query: 1422 NDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSIL--RCYHSKG 1479
+ I CL V++ ++I AT G + IWD+ + + C G
Sbjct: 299 ANIISCLCVSEDRRWI---ATADKGPDC-------LVIIWDSFTGIPVHTIFDSCPEGNG 348
Query: 1480 VCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS-----RAGHNQRIFVAEFRPDSD 1534
+ +++ + K L ++ + IW+W + + + + +V F P ++
Sbjct: 349 IMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVT-FNPTNN 407
Query: 1535 TQFVSVGVKHVKFW-------TLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLT--F 1585
+ VS ++ TLA A L + + L Q++ + NLT
Sbjct: 408 KELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHL-----NLTQIL 462
Query: 1586 TGTISGDVCVWKDHIL---------------CRIVARAHNGPVFAMYTTLRDGLIVTGGK 1630
+ T+ G + VW H C++V G + TT+ D IVTG
Sbjct: 463 SATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEG--ITVLTTI-DSYIVTGDI 519
Query: 1631 ERPSKEGGAVKLWDQELR--------RCRAFRLETGQATDCVRSV--------CRGKGKI 1674
+ G +K +D L + A R + T C KG +
Sbjct: 520 K------GNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPTEKSNYPPDCTLKGDL 573
Query: 1675 ------LVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRL 1728
++GT +A + + L D I ++ HP + + G +++
Sbjct: 574 FVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDA-ICAISCHPYQPLIAIGSICGMIKV 632
Query: 1729 WDIADKKML--NKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKK--RDR 1784
W+ +K+ L G +++ Y+PEG ++ G G IL SL+ + +
Sbjct: 633 WNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYS 692
Query: 1785 RCAIHDIRFSPDSRYLAVGSSENSVDFYDLTL 1816
R ++ I FS DS+Y+A +V Y L +
Sbjct: 693 RTSVTHISFSHDSQYMATADRSFTVAVYMLVV 724
Score = 57.8 bits (138), Expect = 1e-07
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 2/136 (1%)
Query: 4 RSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDD 63
+S P L + W +G+ + + ++Y A ++Y+ + Q +GH++
Sbjct: 242 KSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANI 301
Query: 64 IISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKD--VHTHGIACLAFDLDGQRL 121
I L + +R +AT G + + IWDS+T + + D +GI +A D + L
Sbjct: 302 ISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKYL 361
Query: 122 VSVGLDSKNAVCVWDW 137
++ VC+W W
Sbjct: 362 ATISDAEVQKVCIWKW 377
Score = 39.7 bits (91), Expect = 0.030
Identities = 31/162 (19%), Positives = 70/162 (43%), Gaps = 7/162 (4%)
Query: 295 HILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSL 354
+ ++GT D+ ++ + L ++ + + A++ HP +PL GS +++W+
Sbjct: 578 NFIIGTSDAAVYHLTTDGTKLEKLFVEP--KDAICAISCHPYQPLIAIGSICGMIKVWNY 635
Query: 355 VDHALIARCNMEE--PIRCAAVNADGIHLALGMKDGSFTVLRVRDM--TEVVHIKDRKEA 410
+ + E+ ++ N +G L G +G+ +L + K + +
Sbjct: 636 ENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTS 695
Query: 411 IHELKYSPDGTYLAVGCNDSSVDIYG-VAQRYKKVGECLGSL 451
+ + +S D Y+A +V +Y V + ++V E L L
Sbjct: 696 VTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARL 737
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 64.7 bits (156), Expect = 9e-10
Identities = 53/174 (30%), Positives = 80/174 (45%), Gaps = 22/174 (12%)
Query: 721 RFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDF 780
R +GH +I L HP ++VA+G +D +I +WD + +GH Q V + F
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGS--QDTNIKLWDIRRKGCVFRYRGHSQ-AVRCLRF 155
Query: 781 SADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI--K 838
S DGK LAS D HTV LWD G+ +S G + VV+ +P + L+ +G +
Sbjct: 156 SPDGKWLASAA--DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP--NEYLLASGSSDR 211
Query: 839 HMKFWR----KAGGGLIGRKGYIGTLGKNDTMMC---------AVYGWTEEMAF 879
++FW + + G G + ++ N C VYGW E F
Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCF 265
Score = 58.9 bits (141), Expect = 5e-08
Identities = 53/188 (28%), Positives = 81/188 (43%), Gaps = 18/188 (9%)
Query: 208 DELTYSGALNGDIYVW--KGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWD 263
+EL +G+ +G I VW + ++RT+ G H A I S++ G A+G +D I+LWD
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMG-HKANICSLDFHPYGEFVASGSQDTNIKLWD 133
Query: 264 LTFKPITVIDLRETDQGYKGLSVRSVCWR---GDHILVGTQDSEIFEIVVQERNKPFLIM 320
+ K Y+G S C R L D ++ K
Sbjct: 134 IRRKGCVF--------RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 321 QGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEE-PIRCAAVNADGI 379
GH G + + HP + L +GS DR++R W L +++ E P+R N DG
Sbjct: 186 PGHT-GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGC 244
Query: 380 HLALGMKD 387
L G +D
Sbjct: 245 CLYSGCQD 252
Score = 58.5 bits (140), Expect = 6e-08
Identities = 36/141 (25%), Positives = 75/141 (53%), Gaps = 24/141 (17%)
Query: 1693 CNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-- 1750
C + + GH P+ + + + ++ ++ G++R+WD+ K+L + +GH A +C
Sbjct: 55 CIMSLTGHTS-PVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL-MGHKAN-ICSL 111
Query: 1751 -YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRC---------AIHDIRFSPDSRYL 1800
+ P G+ VA G ++ +++K+W +R + C A+ +RFSPD ++L
Sbjct: 112 DFHPYGEFVASGSQD--------TNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWL 162
Query: 1801 AVGSSENSVDFYDLTLGPTLN 1821
A + +++V +DLT G ++
Sbjct: 163 ASAADDHTVKLWDLTAGKMMS 183
Score = 56.6 bits (135), Expect = 2e-07
Identities = 55/232 (23%), Positives = 98/232 (42%), Gaps = 19/232 (8%)
Query: 896 VKTVKAHDGPVFSM---HALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKG 952
++ + AH V S+ A + TGG D V LW + C+ + + +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE----- 67
Query: 953 LLLEDNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPYLP 1011
S+R ++ I+ G+++G I D ++ I + GH + + L HPY
Sbjct: 68 -------SVR-LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGH-KANICSLDFHPYGE 118
Query: 1012 ICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADT 1071
A+ S D +++WD+ C+ R + RC FSPDGK LA +D + + +
Sbjct: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
Query: 1072 LEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKG 1123
+ + F ++ + F P LA S D I +++ + V +G
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEKFQVVSCIEG 229
Score = 55.8 bits (133), Expect = 4e-07
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 59 GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
GH +I SL HP VA+G ++ I +WD + + H+ + CL F DG
Sbjct: 103 GHKANICSLDFHPYGEFVASGS--QDTNIKLWDIRRKGCVFRYRG-HSQAVRCLRFSPDG 159
Query: 119 QRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNK-LVSCGV--KHIK 175
+ L S D + V +WD GKM+S PGHT + + + PN+ L++ G + I+
Sbjct: 160 KWLASAADD--HTVKLWDLTAGKMMSEFPGHTGPVNVVE---FHPNEYLLASGSSDRTIR 214
Query: 176 FWSL 179
FW L
Sbjct: 215 FWDL 218
Score = 52.0 bits (123), Expect = 6e-06
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 25/247 (10%)
Query: 201 LCLACARDELTYSGALNGDIYVWK--GINLIRTIQGAHAAGIFS--MNACEEGFATGGRD 256
L L A L +G + + +W N I ++ G H + + S +N EE G +
Sbjct: 26 LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTG-HTSPVESVRLNTPEELIVAGSQS 84
Query: 257 GCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWR--GDHILVGTQDSEIFEIVVQERN 314
G IR+WDL I T G+K ++ S+ + G+ + G+QD+ I ++ +
Sbjct: 85 GSIRVWDLEAAKIL-----RTLMGHKA-NICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 315 KPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAV 374
F +GH + + L P + +DD +V++W L +++ E P V
Sbjct: 139 CVFRY-RGHSQA-VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS----EFPGHTGPV 192
Query: 375 NADGIH-----LALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCND 429
N H LA G D + + V I+ + + ++PDG L GC D
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Query: 430 SSVDIYG 436
S+ +YG
Sbjct: 253 -SLRVYG 258
Score = 49.7 bits (117), Expect = 3e-05
Identities = 67/260 (25%), Positives = 109/260 (41%), Gaps = 24/260 (9%)
Query: 1596 WKDHILCRIVARAHNGPVFAMYTTLRDG-LIVTGGKERPSKEGGAVKLWDQELRRCRAFR 1654
WK L IVA A N V ++ G L+ TGG + V LW C
Sbjct: 11 WK---LQEIVAHASN--VSSLVLGKASGRLLATGGDDC------RVNLWSINKPNC--IM 57
Query: 1655 LETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNI-LVNGHVDGPIWGLATHPS 1713
TG + +++V + I V + AA + + GH I L HP
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGH-KANICSLDFHPY 116
Query: 1714 RDFFLSAAEDGTVRLWDIADKKMLNKVNLGH--AARTVCYSPEGDMVAIGMKNGEFIILL 1771
+F S ++D ++LWDI K + + GH A R + +SP+G +A + +
Sbjct: 117 GEFVASGSQDTNIKLWDIRRKGCVFRYR-GHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Query: 1772 VSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPS 1831
+++ K+ + ++ + F P+ LA GSS+ ++ F+DL +S + P
Sbjct: 176 LTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL---EKFQVVSCIEGEPG 232
Query: 1832 FVIQMDFSADSSYLQVSSGC 1851
V + F+ D L SGC
Sbjct: 233 PVRSVLFNPDGCCLY--SGC 250
Score = 47.8 bits (112), Expect = 1e-04
Identities = 43/197 (21%), Positives = 81/197 (41%), Gaps = 29/197 (14%)
Query: 875 EEMAFSGTSTGDVCIW--RDIFLVKTVKAHDGPVFSM--HALEKGFVTGGKDGIVALWDD 930
EE+ +G+ +G + +W +++T+ H + S+ H + +G +D + LWD
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
Query: 931 SFERCLKTY-----AIKRAALAPGSKGLL-LEDNPSIRAISLGHGHILVGTKNGEILEVD 984
+ C+ Y A++ +P K L D+ +++ L G ++
Sbjct: 135 RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG------- 187
Query: 985 KSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGR 1044
+GP+ ++ HP + A+ S D+T+R WDL + + R
Sbjct: 188 HTGPVNVV------------EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVR 235
Query: 1045 CCCFSPDGKALAVGLND 1061
F+PDG L G D
Sbjct: 236 SVLFNPDGCCLYSGCQD 252
Score = 44.3 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 72/183 (39%), Gaps = 17/183 (9%)
Query: 1381 GRDCRNNVHYLNDGDDIIYHTASVGILHNV---------ATGSQS----FYQEHNDDILC 1427
G DCR N+ +N + I+ T + +V GSQS + IL
Sbjct: 40 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKIL- 98
Query: 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSA 1487
T+ H I + G+ + +I +WD K + R HS+ V + FS
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-HSQAVRCLRFSP 157
Query: 1488 TGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKF 1547
GK L S D HT+ +W G ++ GH + V EF P+ + ++F
Sbjct: 158 DGKWLASAADD--HTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 1548 WTL 1550
W L
Sbjct: 216 WDL 218
Score = 43.1 bits (100), Expect = 0.003
Identities = 50/238 (21%), Positives = 91/238 (38%), Gaps = 14/238 (5%)
Query: 1574 LAIAFGANNLTFTGTISGDVCVWK-DHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKER 1632
L + + L TG V +W + C + H PV ++ + LIV G
Sbjct: 26 LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS--- 82
Query: 1633 PSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILV-GTRNAEIIEVGEKNA 1691
+ G++++WD L + R G + G+ + G+++ I +
Sbjct: 83 ---QSGSIRVWD--LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 1692 ACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHA--ARTV 1749
C GH + L P + SAA+D TV+LWD+ KM+++ GH V
Sbjct: 138 GCVFRYRGHSQA-VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP-GHTGPVNVV 195
Query: 1750 CYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSEN 1807
+ P ++A G + + ++ + + F+PD L G ++
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Score = 40.8 bits (94), Expect = 0.013
Identities = 65/253 (25%), Positives = 102/253 (40%), Gaps = 27/253 (10%)
Query: 60 HSDDIISLAL-HPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
H+ ++ SL L L+ATG G + + +W I L HT + + +
Sbjct: 19 HASNVSSLVLGKASGRLLATG--GDDCRVNLWSINKPNCIMSLTG-HTSPVESVRLNTP- 74
Query: 119 QRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVK--HIKF 176
+ L+ G S ++ VWD + K+L GH I S D + + V+ G + +IK
Sbjct: 75 EELIVAGSQS-GSIRVWDLEAAKILRTLMGHKANI--CSLDFHPYGEFVASGSQDTNIKL 131
Query: 177 WSLCGNALTPKRGVFGKTGDLQTILCLACARD-ELTYSGALNGDIYVW---KGINLIRTI 232
W + K VF G Q + CL + D + S A + + +W G +
Sbjct: 132 WD-----IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 233 QGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWR 292
+ + E A+G D IR WDL + V+ E + G VRSV +
Sbjct: 187 GHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL--EKFQVVSCIEGEPG----PVRSVLFN 240
Query: 293 GDH--ILVGTQDS 303
D + G QDS
Sbjct: 241 PDGCCLYSGCQDS 253
Score = 38.9 bits (89), Expect = 0.050
Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 3/102 (2%)
Query: 1457 SIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS 1516
SI +WD + L L H +CS+ F G+ + S D I +W + +
Sbjct: 86 SIRVWDLEAAKILRTLMG-HKANICSLDFHPYGEFVASGSQDTN--IKLWDIRRKGCVFR 142
Query: 1517 RAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSK 1558
GH+Q + F PD + VK W L ++S+
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184
Score = 34.7 bits (78), Expect = 0.95
Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 4/99 (4%)
Query: 520 DINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVI 579
+I S+D + G+ + + IKL + RKG FR Y GHS V +R+S D +W+
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKL--WDIRRKGCVFR-YRGHSQAVRCLRFSPDGKWLA 163
Query: 580 SIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDE 618
S DH+V W + + + ++ + H +E
Sbjct: 164 S-AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE 201
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 62.4 bits (150), Expect = 4e-09
Identities = 54/212 (25%), Positives = 97/212 (45%), Gaps = 25/212 (11%)
Query: 59 GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
GH+ + + LH +RV+ + ++ + +WD T Q + VL H + C+ +D G
Sbjct: 341 GHTSTVRCMHLHEKRVVSGS----RDATLRVWDIETGQCLHVLMG-HVAAVRCVQYD--G 393
Query: 119 QRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGV-KHIKFW 177
+R+VS D V VWD + L GHT+R++ + +D +VS + I+ W
Sbjct: 394 RRVVSGAYDFM--VKVWDPETETCLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVW 448
Query: 178 SL-CGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW--KGINLIRTIQG 234
+ GN + G T ++ +D + SG + + +W K ++T+QG
Sbjct: 449 DVETGNCIHTLTGHQSLTSGME-------LKDNILVSGNADSTVKIWDIKTGQCLQTLQG 501
Query: 235 --AHAAGIFSMNACEEGFATGGRDGCIRLWDL 264
H + + + + T DG ++LWDL
Sbjct: 502 PNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 533
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/234 (26%), Positives = 108/234 (46%), Gaps = 44/234 (18%)
Query: 136 DWKRGKMLS--MAPGHTDRIFDISWDLYQPNKLVSCGVKH-IKFWSLCGNALTPK--RGV 190
+W+RG++ S + GH D + I+ + N++VS + +K WS A+T K R +
Sbjct: 246 NWRRGELKSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWS----AVTGKCLRTL 299
Query: 191 FGKTGDLQTILCLACARDELTYSGALNGDIYVWKGIN--LIRTIQGAHAAGIFSMNACEE 248
G TG + + + RD + SG+ + + VW I T+ G H + + M+ E+
Sbjct: 300 VGHTGGVWS----SQMRDNIIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHEK 354
Query: 249 GFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGL-----SVRSVCWRGDHILVGTQDS 303
+G RD +R+WD+ ET Q L +VR V + G ++ G D
Sbjct: 355 RVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF 403
Query: 304 EIFEIVVQERNKPFLIMQGHCEGELWAL---AVHPTKPLAVTGSDDRSVRIWSL 354
+ ++ E +QGH +++L +H V+GS D S+R+W +
Sbjct: 404 MV-KVWDPETETCLHTLQGH-TNRVYSLQFDGIH-----VVSGSLDTSIRVWDV 450
Score = 50.4 bits (119), Expect = 2e-05
Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 55/323 (17%)
Query: 756 WDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS 815
W +K +LKGH + ++ + F G R+ S G DD+ T+ +W G+ L G
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVS-GSDDN-TLKVWSAVTGKCLRTLVGH 302
Query: 816 KDKIFVVKMNPYVPDKLITAGI--KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGW 873
++ +M D +I +G + +K W G I G T+ C
Sbjct: 303 TGGVWSSQMR----DNIIISGSTDRTLKVWNAETGECIHT-----LYGHTSTVRCMHLH- 352
Query: 874 TEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALE---KGFVTGGKDGIVALWDD 930
E+ SG+ + +W DI + + G V ++ ++ + V+G D +V +WD
Sbjct: 353 -EKRVVSGSRDATLRVW-DIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDP 410
Query: 931 SFERCLKT--------YAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILE 982
E CL T Y+++ + S L + SIR + G+ + + L
Sbjct: 411 ETETCLHTLQGHTNRVYSLQFDGIHVVSGSL----DTSIRVWDVETGNCIHTLTGHQSLT 466
Query: 983 VDKSGPITLLVQGHMEG--EVWGLAT------------HPYLPICA--------TVSDDK 1020
+LV G+ + ++W + T H C T SDD
Sbjct: 467 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG 526
Query: 1021 TLRIWDLSPSHCMLAVRKLKKGG 1043
T+++WDL + + L+ GG
Sbjct: 527 TVKLWDLKTGEFIRNLVTLESGG 549
Score = 48.9 bits (115), Expect = 5e-05
Identities = 73/303 (24%), Positives = 117/303 (38%), Gaps = 54/303 (17%)
Query: 90 WDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGH 149
W +++ VLK H I CL F G R+VS D N + VW GK L GH
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDD--NTLKVWSAVTGKCLRTLVGH 302
Query: 150 TDRIFDISWDLYQPNKLVSCGV--KHIKFWS---------LCGNALT-------PKRGVF 191
T + W + ++ G + +K W+ L G+ T KR V
Sbjct: 303 TGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS 358
Query: 192 G------KTGDLQTILCLACARDELT------------YSGALNGDIYVW--KGINLIRT 231
G + D++T CL + SGA + + VW + + T
Sbjct: 359 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 232 IQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCW 291
+QG H ++S+ +G D IR+WD + + T G++ L+ S
Sbjct: 419 LQG-HTNRVYSLQFDGIHVVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLT--SGME 470
Query: 292 RGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRI 351
D+ILV +I + + +QG + + + K +T SDD +V++
Sbjct: 471 LKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 530
Query: 352 WSL 354
W L
Sbjct: 531 WDL 533
Score = 47.0 bits (110), Expect = 2e-04
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 31/214 (14%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVD-FSAD 783
GH + C+ +H + V +G RD ++ +WD ET + L +L GH V+AV D
Sbjct: 341 GHTSTVRCMHLHEKR--VVSGS--RDATLRVWDIETGQCLHVLMGH----VAAVRCVQYD 392
Query: 784 GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMN--PYVPDKLITAGIKHMK 841
G+R+ S D V +WD + L +G ++++ ++ + V L T+ ++
Sbjct: 393 GRRVVSGAYD--FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTS----IR 446
Query: 842 FWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKA 901
W G I TL + ++ + + + SG + V IW DI + ++
Sbjct: 447 VWDVETGNC------IHTLTGHQSLTSGM-ELKDNILVSGNADSTVKIW-DIKTGQCLQT 498
Query: 902 HDGPVFSMHAL-----EKGFV-TGGKDGIVALWD 929
GP A+ K FV T DG V LWD
Sbjct: 499 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 532
Score = 38.1 bits (87), Expect = 0.086
Identities = 46/242 (19%), Positives = 96/242 (39%), Gaps = 41/242 (16%)
Query: 802 DWKKGEKLS--IARGSKDKIFVVKMNPYVPDKLITAGIKH-MKFWRKAGGG----LIGRK 854
+W++GE S + +G D V+ + +++++ + +K W G L+G
Sbjct: 246 NWRRGELKSPKVLKGHDDH--VITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 303
Query: 855 GYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIF--LVKTVKAHDGPVFSMHAL 912
G + + D ++ SG++ + +W + T+ H V MH
Sbjct: 304 GGVWSSQMRDNII-----------ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 352
Query: 913 EKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
EK V+G +D + +WD +CL +L+ ++R + ++
Sbjct: 353 EKRVVSGSRDATLRVWDIETGQCLH---------------VLMGHVAAVRCVQYDGRRVV 397
Query: 973 VGTKNGEILEVDKSGPITL-LVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSH 1031
G + + D L +QGH V+ L + ++ D ++R+WD+ +
Sbjct: 398 SGAYDFMVKVWDPETETCLHTLQGH-TNRVYSLQFDGIHVVSGSL--DTSIRVWDVETGN 454
Query: 1032 CM 1033
C+
Sbjct: 455 CI 456
Score = 36.2 bits (82), Expect = 0.33
Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 41/320 (12%)
Query: 1457 SIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS 1516
++ +W A+ + L L H+ GV S +++S D T+ +W + G I +
Sbjct: 284 TLKVWSAVTGKCLRTL-VGHTGGVWSSQMR--DNIIISGSTD--RTLKVWNAETGECIHT 338
Query: 1517 RAGHNQRI---FVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTM 1573
GH + + E R S ++ ++ V ++ G+ L G ++ + +
Sbjct: 339 LYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE----TGQCLHVLMGHVAAVRCVQYDGR 394
Query: 1574 LAIAFGANNLTFTGTISGDVCVWKDHI-LCRIVARAHNGPVFAMYTTLRDGLIVTGGKER 1632
++ G V VW C + H V+++ DG+ V G
Sbjct: 395 RVVS---------GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLD 442
Query: 1633 PSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGE-KNA 1691
S +++WD E C + T + S K ILV +++ + K
Sbjct: 443 TS-----IRVWDVETGNC----IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 493
Query: 1692 ACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKML-NKVNL-----GHA 1745
C + G +++F +++++DGTV+LWD+ + + N V L G
Sbjct: 494 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 553
Query: 1746 ARTVCYSPEGDMVAIGMKNG 1765
+ S + A+G +NG
Sbjct: 554 VWRIRASNTKLVCAVGSRNG 573
Score = 34.7 bits (78), Expect = 0.95
Identities = 70/337 (20%), Positives = 128/337 (37%), Gaps = 57/337 (16%)
Query: 1520 HNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFG 1579
H ++ +F+ D F+S+ K + + L+ L K LL + R +LA
Sbjct: 149 HMMQVIEPQFQRD----FISLLPKELALYVLS---FLEPKDLLQAAQTCRYWRILA---- 197
Query: 1580 ANNLTFTGTISGDVCVWKDHILCRIVARAH--NGPVFAMYTTLRDGLIVTGGKERPSKEG 1637
+NL + + HI R V + + P + Y +R I T + K
Sbjct: 198 EDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAY--IRQHRIDTNWRRGELKSP 255
Query: 1638 GAVKLWDQELRRCRAF---RLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACN 1694
+K D + C F R+ +G + ++ GK L T V N
Sbjct: 256 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCL-RTLVGHTGGVWSSQMRDN 314
Query: 1695 ILVNGHVDGP--IWGLAT-----------------HPSRDFFLSAAEDGTVRLWDIADKK 1735
I+++G D +W T H +S + D T+R+WDI +
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQ 374
Query: 1736 MLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRD--------RRCA 1787
L+ V +GH A C +G V G +F++ K+W + +
Sbjct: 375 CLH-VLMGHVAAVRCVQYDGRRVVSGAY--DFMV------KVWDPETETCLHTLQGHTNR 425
Query: 1788 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIS 1824
++ ++F D ++ GS + S+ +D+ G ++ ++
Sbjct: 426 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 460
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 62.4 bits (150), Expect = 4e-09
Identities = 54/212 (25%), Positives = 97/212 (45%), Gaps = 25/212 (11%)
Query: 59 GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
GH+ + + LH +RV+ + ++ + +WD T Q + VL H + C+ +D G
Sbjct: 459 GHTSTVRCMHLHEKRVVSGS----RDATLRVWDIETGQCLHVLMG-HVAAVRCVQYD--G 511
Query: 119 QRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGV-KHIKFW 177
+R+VS D V VWD + L GHT+R++ + +D +VS + I+ W
Sbjct: 512 RRVVSGAYDFM--VKVWDPETETCLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVW 566
Query: 178 SL-CGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW--KGINLIRTIQG 234
+ GN + G T ++ +D + SG + + +W K ++T+QG
Sbjct: 567 DVETGNCIHTLTGHQSLTSGME-------LKDNILVSGNADSTVKIWDIKTGQCLQTLQG 619
Query: 235 --AHAAGIFSMNACEEGFATGGRDGCIRLWDL 264
H + + + + T DG ++LWDL
Sbjct: 620 PNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/234 (26%), Positives = 108/234 (46%), Gaps = 44/234 (18%)
Query: 136 DWKRGKMLS--MAPGHTDRIFDISWDLYQPNKLVSCGVKH-IKFWSLCGNALTPK--RGV 190
+W+RG++ S + GH D + I+ + N++VS + +K WS A+T K R +
Sbjct: 364 NWRRGELKSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWS----AVTGKCLRTL 417
Query: 191 FGKTGDLQTILCLACARDELTYSGALNGDIYVWKGIN--LIRTIQGAHAAGIFSMNACEE 248
G TG + + + RD + SG+ + + VW I T+ G H + + M+ E+
Sbjct: 418 VGHTGGVWS----SQMRDNIIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHEK 472
Query: 249 GFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGL-----SVRSVCWRGDHILVGTQDS 303
+G RD +R+WD+ ET Q L +VR V + G ++ G D
Sbjct: 473 RVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF 521
Query: 304 EIFEIVVQERNKPFLIMQGHCEGELWAL---AVHPTKPLAVTGSDDRSVRIWSL 354
+ ++ E +QGH +++L +H V+GS D S+R+W +
Sbjct: 522 MV-KVWDPETETCLHTLQGH-TNRVYSLQFDGIH-----VVSGSLDTSIRVWDV 568
Score = 50.4 bits (119), Expect = 2e-05
Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 55/323 (17%)
Query: 756 WDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS 815
W +K +LKGH + ++ + F G R+ S G DD+ T+ +W G+ L G
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVS-GSDDN-TLKVWSAVTGKCLRTLVGH 420
Query: 816 KDKIFVVKMNPYVPDKLITAGI--KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGW 873
++ +M D +I +G + +K W G I G T+ C
Sbjct: 421 TGGVWSSQMR----DNIIISGSTDRTLKVWNAETGECIHT-----LYGHTSTVRCMHLH- 470
Query: 874 TEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALE---KGFVTGGKDGIVALWDD 930
E+ SG+ + +W DI + + G V ++ ++ + V+G D +V +WD
Sbjct: 471 -EKRVVSGSRDATLRVW-DIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDP 528
Query: 931 SFERCLKT--------YAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILE 982
E CL T Y+++ + S L + SIR + G+ + + L
Sbjct: 529 ETETCLHTLQGHTNRVYSLQFDGIHVVSGSL----DTSIRVWDVETGNCIHTLTGHQSLT 584
Query: 983 VDKSGPITLLVQGHMEG--EVWGLAT------------HPYLPICA--------TVSDDK 1020
+LV G+ + ++W + T H C T SDD
Sbjct: 585 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG 644
Query: 1021 TLRIWDLSPSHCMLAVRKLKKGG 1043
T+++WDL + + L+ GG
Sbjct: 645 TVKLWDLKTGEFIRNLVTLESGG 667
Score = 48.9 bits (115), Expect = 5e-05
Identities = 73/303 (24%), Positives = 117/303 (38%), Gaps = 54/303 (17%)
Query: 90 WDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGH 149
W +++ VLK H I CL F G R+VS D N + VW GK L GH
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDD--NTLKVWSAVTGKCLRTLVGH 420
Query: 150 TDRIFDISWDLYQPNKLVSCGV--KHIKFWS---------LCGNALT-------PKRGVF 191
T + W + ++ G + +K W+ L G+ T KR V
Sbjct: 421 TGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS 476
Query: 192 G------KTGDLQTILCLACARDELT------------YSGALNGDIYVW--KGINLIRT 231
G + D++T CL + SGA + + VW + + T
Sbjct: 477 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 232 IQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCW 291
+QG H ++S+ +G D IR+WD + + T G++ L+ S
Sbjct: 537 LQG-HTNRVYSLQFDGIHVVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLT--SGME 588
Query: 292 RGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRI 351
D+ILV +I + + +QG + + + K +T SDD +V++
Sbjct: 589 LKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 648
Query: 352 WSL 354
W L
Sbjct: 649 WDL 651
Score = 47.0 bits (110), Expect = 2e-04
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 31/214 (14%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVD-FSAD 783
GH + C+ +H + V +G RD ++ +WD ET + L +L GH V+AV D
Sbjct: 459 GHTSTVRCMHLHEKR--VVSGS--RDATLRVWDIETGQCLHVLMGH----VAAVRCVQYD 510
Query: 784 GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMN--PYVPDKLITAGIKHMK 841
G+R+ S D V +WD + L +G ++++ ++ + V L T+ ++
Sbjct: 511 GRRVVSGAYD--FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTS----IR 564
Query: 842 FWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKA 901
W G I TL + ++ + + + SG + V IW DI + ++
Sbjct: 565 VWDVETGNC------IHTLTGHQSLTSGM-ELKDNILVSGNADSTVKIW-DIKTGQCLQT 616
Query: 902 HDGPVFSMHAL-----EKGFV-TGGKDGIVALWD 929
GP A+ K FV T DG V LWD
Sbjct: 617 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 650
Score = 38.1 bits (87), Expect = 0.086
Identities = 46/242 (19%), Positives = 96/242 (39%), Gaps = 41/242 (16%)
Query: 802 DWKKGEKLS--IARGSKDKIFVVKMNPYVPDKLITAGIKH-MKFWRKAGGG----LIGRK 854
+W++GE S + +G D V+ + +++++ + +K W G L+G
Sbjct: 364 NWRRGELKSPKVLKGHDDH--VITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 421
Query: 855 GYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIF--LVKTVKAHDGPVFSMHAL 912
G + + D ++ SG++ + +W + T+ H V MH
Sbjct: 422 GGVWSSQMRDNII-----------ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
Query: 913 EKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
EK V+G +D + +WD +CL +L+ ++R + ++
Sbjct: 471 EKRVVSGSRDATLRVWDIETGQCLH---------------VLMGHVAAVRCVQYDGRRVV 515
Query: 973 VGTKNGEILEVDKSGPITL-LVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSH 1031
G + + D L +QGH V+ L + ++ D ++R+WD+ +
Sbjct: 516 SGAYDFMVKVWDPETETCLHTLQGH-TNRVYSLQFDGIHVVSGSL--DTSIRVWDVETGN 572
Query: 1032 CM 1033
C+
Sbjct: 573 CI 574
Score = 36.2 bits (82), Expect = 0.33
Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 41/320 (12%)
Query: 1457 SIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS 1516
++ +W A+ + L L H+ GV S +++S D T+ +W + G I +
Sbjct: 402 TLKVWSAVTGKCLRTL-VGHTGGVWSSQMR--DNIIISGSTD--RTLKVWNAETGECIHT 456
Query: 1517 RAGHNQRI---FVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTM 1573
GH + + E R S ++ ++ V ++ G+ L G ++ + +
Sbjct: 457 LYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE----TGQCLHVLMGHVAAVRCVQYDGR 512
Query: 1574 LAIAFGANNLTFTGTISGDVCVWKDHI-LCRIVARAHNGPVFAMYTTLRDGLIVTGGKER 1632
++ G V VW C + H V+++ DG+ V G
Sbjct: 513 RVVS---------GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLD 560
Query: 1633 PSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGE-KNA 1691
S +++WD E C + T + S K ILV +++ + K
Sbjct: 561 TS-----IRVWDVETGNC----IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 611
Query: 1692 ACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKML-NKVNL-----GHA 1745
C + G +++F +++++DGTV+LWD+ + + N V L G
Sbjct: 612 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 671
Query: 1746 ARTVCYSPEGDMVAIGMKNG 1765
+ S + A+G +NG
Sbjct: 672 VWRIRASNTKLVCAVGSRNG 691
Score = 34.7 bits (78), Expect = 0.95
Identities = 70/337 (20%), Positives = 128/337 (37%), Gaps = 57/337 (16%)
Query: 1520 HNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFG 1579
H ++ +F+ D F+S+ K + + L+ L K LL + R +LA
Sbjct: 267 HMMQVIEPQFQRD----FISLLPKELALYVLS---FLEPKDLLQAAQTCRYWRILA---- 315
Query: 1580 ANNLTFTGTISGDVCVWKDHILCRIVARAH--NGPVFAMYTTLRDGLIVTGGKERPSKEG 1637
+NL + + HI R V + + P + Y +R I T + K
Sbjct: 316 EDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAY--IRQHRIDTNWRRGELKSP 373
Query: 1638 GAVKLWDQELRRCRAF---RLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACN 1694
+K D + C F R+ +G + ++ GK L T V N
Sbjct: 374 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCL-RTLVGHTGGVWSSQMRDN 432
Query: 1695 ILVNGHVDGP--IWGLAT-----------------HPSRDFFLSAAEDGTVRLWDIADKK 1735
I+++G D +W T H +S + D T+R+WDI +
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQ 492
Query: 1736 MLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRD--------RRCA 1787
L+ V +GH A C +G V G +F++ K+W + +
Sbjct: 493 CLH-VLMGHVAAVRCVQYDGRRVVSGAY--DFMV------KVWDPETETCLHTLQGHTNR 543
Query: 1788 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIS 1824
++ ++F D ++ GS + S+ +D+ G ++ ++
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 578
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 62.4 bits (150), Expect = 4e-09
Identities = 54/212 (25%), Positives = 97/212 (45%), Gaps = 25/212 (11%)
Query: 59 GHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDG 118
GH+ + + LH +RV+ + ++ + +WD T Q + VL H + C+ +D G
Sbjct: 379 GHTSTVRCMHLHEKRVVSGS----RDATLRVWDIETGQCLHVLMG-HVAAVRCVQYD--G 431
Query: 119 QRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGV-KHIKFW 177
+R+VS D V VWD + L GHT+R++ + +D +VS + I+ W
Sbjct: 432 RRVVSGAYDFM--VKVWDPETETCLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVW 486
Query: 178 SL-CGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW--KGINLIRTIQG 234
+ GN + G T ++ +D + SG + + +W K ++T+QG
Sbjct: 487 DVETGNCIHTLTGHQSLTSGME-------LKDNILVSGNADSTVKIWDIKTGQCLQTLQG 539
Query: 235 --AHAAGIFSMNACEEGFATGGRDGCIRLWDL 264
H + + + + T DG ++LWDL
Sbjct: 540 PNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/234 (26%), Positives = 108/234 (46%), Gaps = 44/234 (18%)
Query: 136 DWKRGKMLS--MAPGHTDRIFDISWDLYQPNKLVSCGVKH-IKFWSLCGNALTPK--RGV 190
+W+RG++ S + GH D + I+ + N++VS + +K WS A+T K R +
Sbjct: 284 NWRRGELKSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWS----AVTGKCLRTL 337
Query: 191 FGKTGDLQTILCLACARDELTYSGALNGDIYVWKGIN--LIRTIQGAHAAGIFSMNACEE 248
G TG + + + RD + SG+ + + VW I T+ G H + + M+ E+
Sbjct: 338 VGHTGGVWS----SQMRDNIIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHEK 392
Query: 249 GFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGL-----SVRSVCWRGDHILVGTQDS 303
+G RD +R+WD+ ET Q L +VR V + G ++ G D
Sbjct: 393 RVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF 441
Query: 304 EIFEIVVQERNKPFLIMQGHCEGELWAL---AVHPTKPLAVTGSDDRSVRIWSL 354
+ ++ E +QGH +++L +H V+GS D S+R+W +
Sbjct: 442 MV-KVWDPETETCLHTLQGH-TNRVYSLQFDGIH-----VVSGSLDTSIRVWDV 488
Score = 50.4 bits (119), Expect = 2e-05
Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 55/323 (17%)
Query: 756 WDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS 815
W +K +LKGH + ++ + F G R+ S G DD+ T+ +W G+ L G
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVS-GSDDN-TLKVWSAVTGKCLRTLVGH 340
Query: 816 KDKIFVVKMNPYVPDKLITAGI--KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGW 873
++ +M D +I +G + +K W G I G T+ C
Sbjct: 341 TGGVWSSQMR----DNIIISGSTDRTLKVWNAETGECIHT-----LYGHTSTVRCMHLH- 390
Query: 874 TEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALE---KGFVTGGKDGIVALWDD 930
E+ SG+ + +W DI + + G V ++ ++ + V+G D +V +WD
Sbjct: 391 -EKRVVSGSRDATLRVW-DIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDP 448
Query: 931 SFERCLKT--------YAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILE 982
E CL T Y+++ + S L + SIR + G+ + + L
Sbjct: 449 ETETCLHTLQGHTNRVYSLQFDGIHVVSGSL----DTSIRVWDVETGNCIHTLTGHQSLT 504
Query: 983 VDKSGPITLLVQGHMEG--EVWGLAT------------HPYLPICA--------TVSDDK 1020
+LV G+ + ++W + T H C T SDD
Sbjct: 505 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG 564
Query: 1021 TLRIWDLSPSHCMLAVRKLKKGG 1043
T+++WDL + + L+ GG
Sbjct: 565 TVKLWDLKTGEFIRNLVTLESGG 587
Score = 48.9 bits (115), Expect = 5e-05
Identities = 73/303 (24%), Positives = 117/303 (38%), Gaps = 54/303 (17%)
Query: 90 WDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGH 149
W +++ VLK H I CL F G R+VS D N + VW GK L GH
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDD--NTLKVWSAVTGKCLRTLVGH 340
Query: 150 TDRIFDISWDLYQPNKLVSCGV--KHIKFWS---------LCGNALT-------PKRGVF 191
T + W + ++ G + +K W+ L G+ T KR V
Sbjct: 341 TGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS 396
Query: 192 G------KTGDLQTILCLACARDELT------------YSGALNGDIYVW--KGINLIRT 231
G + D++T CL + SGA + + VW + + T
Sbjct: 397 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 232 IQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCW 291
+QG H ++S+ +G D IR+WD + + T G++ L+ S
Sbjct: 457 LQG-HTNRVYSLQFDGIHVVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLT--SGME 508
Query: 292 RGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRI 351
D+ILV +I + + +QG + + + K +T SDD +V++
Sbjct: 509 LKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 568
Query: 352 WSL 354
W L
Sbjct: 569 WDL 571
Score = 47.0 bits (110), Expect = 2e-04
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 31/214 (14%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVD-FSAD 783
GH + C+ +H + V +G RD ++ +WD ET + L +L GH V+AV D
Sbjct: 379 GHTSTVRCMHLHEKR--VVSGS--RDATLRVWDIETGQCLHVLMGH----VAAVRCVQYD 430
Query: 784 GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMN--PYVPDKLITAGIKHMK 841
G+R+ S D V +WD + L +G ++++ ++ + V L T+ ++
Sbjct: 431 GRRVVSGAYD--FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTS----IR 484
Query: 842 FWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKA 901
W G I TL + ++ + + + SG + V IW DI + ++
Sbjct: 485 VWDVETGNC------IHTLTGHQSLTSGM-ELKDNILVSGNADSTVKIW-DIKTGQCLQT 536
Query: 902 HDGPVFSMHAL-----EKGFV-TGGKDGIVALWD 929
GP A+ K FV T DG V LWD
Sbjct: 537 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 570
Score = 38.1 bits (87), Expect = 0.086
Identities = 46/242 (19%), Positives = 96/242 (39%), Gaps = 41/242 (16%)
Query: 802 DWKKGEKLS--IARGSKDKIFVVKMNPYVPDKLITAGIKH-MKFWRKAGGG----LIGRK 854
+W++GE S + +G D V+ + +++++ + +K W G L+G
Sbjct: 284 NWRRGELKSPKVLKGHDDH--VITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 341
Query: 855 GYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIF--LVKTVKAHDGPVFSMHAL 912
G + + D ++ SG++ + +W + T+ H V MH
Sbjct: 342 GGVWSSQMRDNII-----------ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 390
Query: 913 EKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
EK V+G +D + +WD +CL +L+ ++R + ++
Sbjct: 391 EKRVVSGSRDATLRVWDIETGQCLH---------------VLMGHVAAVRCVQYDGRRVV 435
Query: 973 VGTKNGEILEVDKSGPITL-LVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSH 1031
G + + D L +QGH V+ L + ++ D ++R+WD+ +
Sbjct: 436 SGAYDFMVKVWDPETETCLHTLQGH-TNRVYSLQFDGIHVVSGSL--DTSIRVWDVETGN 492
Query: 1032 CM 1033
C+
Sbjct: 493 CI 494
Score = 36.2 bits (82), Expect = 0.33
Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 41/320 (12%)
Query: 1457 SIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIAS 1516
++ +W A+ + L L H+ GV S +++S D T+ +W + G I +
Sbjct: 322 TLKVWSAVTGKCLRTL-VGHTGGVWSSQMR--DNIIISGSTD--RTLKVWNAETGECIHT 376
Query: 1517 RAGHNQRI---FVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTM 1573
GH + + E R S ++ ++ V ++ G+ L G ++ + +
Sbjct: 377 LYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE----TGQCLHVLMGHVAAVRCVQYDGR 432
Query: 1574 LAIAFGANNLTFTGTISGDVCVWKDHI-LCRIVARAHNGPVFAMYTTLRDGLIVTGGKER 1632
++ G V VW C + H V+++ DG+ V G
Sbjct: 433 RVVS---------GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHVVSGSLD 480
Query: 1633 PSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGE-KNA 1691
S +++WD E C + T + S K ILV +++ + K
Sbjct: 481 TS-----IRVWDVETGNC----IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 531
Query: 1692 ACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKML-NKVNL-----GHA 1745
C + G +++F +++++DGTV+LWD+ + + N V L G
Sbjct: 532 QCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 591
Query: 1746 ARTVCYSPEGDMVAIGMKNG 1765
+ S + A+G +NG
Sbjct: 592 VWRIRASNTKLVCAVGSRNG 611
Score = 34.7 bits (78), Expect = 0.95
Identities = 70/337 (20%), Positives = 128/337 (37%), Gaps = 57/337 (16%)
Query: 1520 HNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFG 1579
H ++ +F+ D F+S+ K + + L+ L K LL + R +LA
Sbjct: 187 HMMQVIEPQFQRD----FISLLPKELALYVLS---FLEPKDLLQAAQTCRYWRILA---- 235
Query: 1580 ANNLTFTGTISGDVCVWKDHILCRIVARAH--NGPVFAMYTTLRDGLIVTGGKERPSKEG 1637
+NL + + HI R V + + P + Y +R I T + K
Sbjct: 236 EDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAY--IRQHRIDTNWRRGELKSP 293
Query: 1638 GAVKLWDQELRRCRAF---RLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACN 1694
+K D + C F R+ +G + ++ GK L T V N
Sbjct: 294 KVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCL-RTLVGHTGGVWSSQMRDN 352
Query: 1695 ILVNGHVDGP--IWGLAT-----------------HPSRDFFLSAAEDGTVRLWDIADKK 1735
I+++G D +W T H +S + D T+R+WDI +
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQ 412
Query: 1736 MLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRD--------RRCA 1787
L+ V +GH A C +G V G +F++ K+W + +
Sbjct: 413 CLH-VLMGHVAAVRCVQYDGRRVVSGAY--DFMV------KVWDPETETCLHTLQGHTNR 463
Query: 1788 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIS 1824
++ ++F D ++ GS + S+ +D+ G ++ ++
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 498
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 60.5 bits (145), Expect = 2e-08
Identities = 50/212 (23%), Positives = 90/212 (42%), Gaps = 19/212 (8%)
Query: 64 IISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVS 123
I+S P+ V +G + ICI D+ + T+SV+KD HT I FD D QR+ S
Sbjct: 189 IVSCKFSPDGKYVVSG-FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVAS 247
Query: 124 VGLDSKNAVCVWD-WKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSL--- 179
V LD + +WD + +L++ H++ I + + S K++K W++
Sbjct: 248 VSLD--RCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTG 305
Query: 180 ----CGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQ-G 234
CG +T +G G C SG + + +W R +
Sbjct: 306 EFRNCGACVTLMQGHEGSVSS-----CHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK 360
Query: 235 AHAAGIF--SMNACEEGFATGGRDGCIRLWDL 264
H + +++ ++ + +D +RLW++
Sbjct: 361 GHNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
Score = 43.1 bits (100), Expect = 0.003
Identities = 66/313 (21%), Positives = 118/313 (37%), Gaps = 70/313 (22%)
Query: 1432 QHPKFINIVATGQVGDSADMSATA--PSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATG 1489
+H +V GDS+ + A + ++ WD + L +R + + S FS G
Sbjct: 141 EHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR--YDTFIVSCKFSPDG 198
Query: 1490 KLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQR-IFVAEFRPDSDTQFVSVGVKH-VKF 1547
K ++S G D +H I I + ++ H+ R I F PDS + SV + +K
Sbjct: 199 KYVVS-GFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQ-RVASVSLDRCIKI 256
Query: 1548 WTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHI------- 1600
W + +A L L T + + F + L T + ++ +W H
Sbjct: 257 WDVTSQATL----LTITKAHSNAISNCCFTFSGHFLC-TSSWDKNLKIWNVHTGEFRNCG 311
Query: 1601 LCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQA 1660
C + + H G V + + +++GG +R V +WD
Sbjct: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDR------TVAIWD---------------- 349
Query: 1661 TDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSA 1720
V G K+ + N +++V N ++ + LSA
Sbjct: 350 ------VAEGYRKLSLKGHNDWVMDVAISN----------------------NKKWILSA 381
Query: 1721 AEDGTVRLWDIAD 1733
++D T+RLW+I +
Sbjct: 382 SKDRTMRLWNIEE 394
Score = 42.7 bits (99), Expect = 0.003
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 726 HDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGK 785
+D I+ P YV +G D I I D E I +S++K HH +++ F D +
Sbjct: 185 YDTFIVSCKFSPDGKYVVSG-FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQ 243
Query: 786 RLASVGIDDSHTVVLWD 802
R+ASV +D + +WD
Sbjct: 244 RVASVSLD--RCIKIWD 258
Score = 40.8 bits (94), Expect = 0.013
Identities = 36/150 (24%), Positives = 68/150 (45%), Gaps = 8/150 (5%)
Query: 1718 LSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILL----VS 1773
++A+ D TVR WD+ K+L KV + +SP+G V G I ++ ++
Sbjct: 161 IAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENIT 220
Query: 1774 SLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFV 1833
++ + R +I F PDS+ +A S + + +D+T TL ++ K + +
Sbjct: 221 TVSVIKDHHTR--SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL--LTITKAHSNAI 276
Query: 1834 IQMDFSADSSYLQVSSGCYKRHVYEVPSGK 1863
F+ +L SS ++ V +G+
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGE 306
Score = 40.0 bits (92), Expect = 0.023
Identities = 43/145 (29%), Positives = 63/145 (43%), Gaps = 19/145 (13%)
Query: 1017 SDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLN-DGSFLMANAD--TLE 1073
S DKT+R WDL + VR C FSPDGK + G + D + +A+ T
Sbjct: 164 SYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTV 222
Query: 1074 DLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMS-----------SKRVGICK 1122
++ HH + I+ F P S + +A S D I I++V S S + C
Sbjct: 223 SVIKDHHTRS-ITSCCFDPDSQR-VASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCC 280
Query: 1123 GATS--YITHIDWDIRGKLLQVNTG 1145
S ++ WD K+ V+TG
Sbjct: 281 FTFSGHFLCTSSWDKNLKIWNVHTG 305
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.1 bits (144), Expect = 2e-08
Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 59/362 (16%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 171 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 856 YIGTLGKNDTMMCAVYGWTEE--MAFSGTSTGDVCIWRDIF-LVKTVKAHDGPVFSMHAL 912
+ K+ T + W + + G+ G IW + L T+ H GP+F++
Sbjct: 230 HDVPSNKDVTSL----DWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 913 EKG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGH 970
+KG ++ G D +WD + + A P++ + +
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA--------------PALD-VDWQNNM 330
Query: 971 ILVGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDL 1027
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 331 TFASCSTDMCIHVCRLGCDHPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSM 388
Query: 1028 SPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV----------- 1076
C+ ++ K +SP G A + N S +M + + + V
Sbjct: 389 KQDACVHDLQAHSKEIYTIKWSPTGPATS---NPNSSIMLASASFDSTVRLWDVEQGVCT 445
Query: 1077 -SFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDI 1135
+ ++ + + FSP GKYLA S D ++ I+N S V +G T I + W+
Sbjct: 446 HTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNA 503
Query: 1136 RG 1137
RG
Sbjct: 504 RG 505
Score = 45.4 bits (106), Expect = 5e-04
Identities = 77/352 (21%), Positives = 133/352 (37%), Gaps = 70/352 (19%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 177 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D+++DG LA D + W + L+ G K IF +K N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI----WTENGNLASTLGQHKGPIFALKWNK-KGN 289
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W M F+ ST D+C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNMTFASCST-DMC-- 340
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + H F H E + G++ L S + LK +++K+ A
Sbjct: 341 --IHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQDACV--- 394
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYL 1010
+ +K ++ +GP T ++P
Sbjct: 395 ------------------HDLQAHSKEIYTIKWSPTGPAT---------------SNPNS 421
Query: 1011 PI-CATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
I A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Score = 44.3 bits (103), Expect = 0.001
Identities = 53/236 (22%), Positives = 92/236 (38%), Gaps = 23/236 (9%)
Query: 214 GALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITV 271
G+ +G +W + + G H IF++ ++G + G D +WD
Sbjct: 253 GSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA------- 305
Query: 272 IDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELW 329
E Q + S + V W+ + + + P QGH E+
Sbjct: 306 -HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN-EVN 363
Query: 330 ALAVHPTKPLAVTGSDDRSVRIWSLVDHALI--ARCNMEE-------PIRCAAVNADG-I 379
A+ P+ L + SDD +++IWS+ A + + + +E P A N + I
Sbjct: 364 AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSI 423
Query: 380 HLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
LA D + + V + +E ++ + +SPDG YLA G D V I+
Sbjct: 424 MLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 40.8 bits (94), Expect = 0.013
Identities = 67/352 (19%), Positives = 127/352 (36%), Gaps = 97/352 (27%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL-------------------AGRALLSKK 1559
GH +F+ + P SD G + W L G + S K
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTT 1619
+ S L+ T+LA+ G+ G +W ++ H GP+FA+
Sbjct: 237 DVTS-LDWNSDGTLLAM----------GSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 1620 LRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTR 1679
+ +++ G ++ + +WD G+ K
Sbjct: 286 KKGNYVLSAGVDKTTI------IWDAHT----------------------GEAKQQFPFH 317
Query: 1680 NAEIIEVGEKN----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSA 1720
+A ++V +N A+C+ + HV D P+ H PS S
Sbjct: 318 SAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASC 377
Query: 1721 AEDGTVRLWDIADKKMLNKVNLGHAAR--TVCYSPEGDMVAIGMKNGEFIILLVSS---- 1774
++D T+++W + ++ + H+ T+ +SP G + N I+L S+
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQ-AHSKEIYTIKWSPTGPATS----NPNSSIMLASASFDS 432
Query: 1775 -LKIWGKKRD--------RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+++W ++ + ++ + FSPD +YLA GS + V ++ G
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 40.0 bits (92), Expect = 0.023
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 174 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N+DG LA+G DG F + + + K I LK++ G Y
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDG-FARIWTENGNLASTLGQHKGPIFALKWNKKGNYV 291
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 292 LSAGVDKTTI 301
Score = 37.7 bits (86), Expect = 0.11
Identities = 70/338 (20%), Positives = 120/338 (35%), Gaps = 61/338 (18%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + + L+A G + + IW ++ H I L ++ G ++
Sbjct: 237 DVTSLDWNSDGTLLAMGSY--DGFARIWTENG--NLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W N + +C
Sbjct: 293 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ----NNMTFASCSTDMCIHVCRL 346
Query: 183 ALT-PKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGA 235
P + G T ++ I + LA D++T I+ K + +Q A
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQDACVHDLQ-A 399
Query: 236 HAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDH 295
H+ I+++ G AT + I L +F + + L + +QG VC H
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFD--STVRLWDVEQG--------VC---TH 446
Query: 296 ILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLV 355
L+ Q+ ++++A P +GS D+ V IW+
Sbjct: 447 TLMKHQE------------------------PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
Query: 356 DHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVL 393
+L+ I NA G + DGS VL
Sbjct: 483 SGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 37.4 bits (85), Expect = 0.15
Identities = 39/188 (20%), Positives = 72/188 (38%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN+ + + D+ H +G H V T +Q H +++ N +
Sbjct: 325 DWQNNMTFASCSTDMCIHVCRLGCDHPVKT-----FQGHTNEV------------NAIKW 367
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + L+ HSK + ++ +S TG +L
Sbjct: 368 DPSGMLLASCSDDMTLKIWSMKQDACVHDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W ++G + H + ++ F PD K+V W T +G
Sbjct: 427 SASFDS--TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 485 SLVHSYQG 492
Score = 32.3 bits (72), Expect = 4.7
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Query: 750 DPSIHIWDTET-IKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEK 808
D ++ +WD E + +++K HQ V +V FS DGK LAS D V +W+ + G
Sbjct: 431 DSTVRLWDVEQGVCTHTLMK--HQEPVYSVAFSPDGKYLASGSFD--KYVHIWNTQSGSL 486
Query: 809 LSIARGS 815
+ +G+
Sbjct: 487 VHSYQGT 493
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.1 bits (144), Expect = 2e-08
Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 59/362 (16%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 171 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 856 YIGTLGKNDTMMCAVYGWTEE--MAFSGTSTGDVCIWRDIF-LVKTVKAHDGPVFSMHAL 912
+ K+ T + W + + G+ G IW + L T+ H GP+F++
Sbjct: 230 HDVPSNKDVTSL----DWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 913 EKG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGH 970
+KG ++ G D +WD + + A P++ + +
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA--------------PALD-VDWQNNM 330
Query: 971 ILVGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDL 1027
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 331 TFASCSTDMCIHVCRLGCDHPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSM 388
Query: 1028 SPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV----------- 1076
C+ ++ K +SP G A + N S +M + + + V
Sbjct: 389 KQDACVHDLQAHSKEIYTIKWSPTGPATS---NPNSSIMLASASFDSTVRLWDVEQGVCT 445
Query: 1077 -SFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDI 1135
+ ++ + + FSP GKYLA S D ++ I+N S V +G T I + W+
Sbjct: 446 HTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNA 503
Query: 1136 RG 1137
RG
Sbjct: 504 RG 505
Score = 45.4 bits (106), Expect = 5e-04
Identities = 77/352 (21%), Positives = 133/352 (37%), Gaps = 70/352 (19%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 177 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D+++DG LA D + W + L+ G K IF +K N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI----WTENGNLASTLGQHKGPIFALKWNK-KGN 289
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W M F+ ST D+C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNMTFASCST-DMC-- 340
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + H F H E + G++ L S + LK +++K+ A
Sbjct: 341 --IHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQDACV--- 394
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYL 1010
+ +K ++ +GP T ++P
Sbjct: 395 ------------------HDLQAHSKEIYTIKWSPTGPAT---------------SNPNS 421
Query: 1011 PI-CATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
I A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Score = 44.3 bits (103), Expect = 0.001
Identities = 53/236 (22%), Positives = 92/236 (38%), Gaps = 23/236 (9%)
Query: 214 GALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITV 271
G+ +G +W + + G H IF++ ++G + G D +WD
Sbjct: 253 GSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA------- 305
Query: 272 IDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELW 329
E Q + S + V W+ + + + P QGH E+
Sbjct: 306 -HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN-EVN 363
Query: 330 ALAVHPTKPLAVTGSDDRSVRIWSLVDHALI--ARCNMEE-------PIRCAAVNADG-I 379
A+ P+ L + SDD +++IWS+ A + + + +E P A N + I
Sbjct: 364 AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSI 423
Query: 380 HLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
LA D + + V + +E ++ + +SPDG YLA G D V I+
Sbjct: 424 MLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 40.8 bits (94), Expect = 0.013
Identities = 67/352 (19%), Positives = 127/352 (36%), Gaps = 97/352 (27%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL-------------------AGRALLSKK 1559
GH +F+ + P SD G + W L G + S K
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTT 1619
+ S L+ T+LA+ G+ G +W ++ H GP+FA+
Sbjct: 237 DVTS-LDWNSDGTLLAM----------GSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 1620 LRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTR 1679
+ +++ G ++ + +WD G+ K
Sbjct: 286 KKGNYVLSAGVDKTTI------IWDAHT----------------------GEAKQQFPFH 317
Query: 1680 NAEIIEVGEKN----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSA 1720
+A ++V +N A+C+ + HV D P+ H PS S
Sbjct: 318 SAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASC 377
Query: 1721 AEDGTVRLWDIADKKMLNKVNLGHAAR--TVCYSPEGDMVAIGMKNGEFIILLVSS---- 1774
++D T+++W + ++ + H+ T+ +SP G + N I+L S+
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQ-AHSKEIYTIKWSPTGPATS----NPNSSIMLASASFDS 432
Query: 1775 -LKIWGKKRD--------RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+++W ++ + ++ + FSPD +YLA GS + V ++ G
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 40.0 bits (92), Expect = 0.023
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 174 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N+DG LA+G DG F + + + K I LK++ G Y
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDG-FARIWTENGNLASTLGQHKGPIFALKWNKKGNYV 291
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 292 LSAGVDKTTI 301
Score = 37.7 bits (86), Expect = 0.11
Identities = 70/338 (20%), Positives = 120/338 (35%), Gaps = 61/338 (18%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + + L+A G + + IW ++ H I L ++ G ++
Sbjct: 237 DVTSLDWNSDGTLLAMGSY--DGFARIWTENG--NLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W N + +C
Sbjct: 293 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ----NNMTFASCSTDMCIHVCRL 346
Query: 183 ALT-PKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGA 235
P + G T ++ I + LA D++T I+ K + +Q A
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQDACVHDLQ-A 399
Query: 236 HAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDH 295
H+ I+++ G AT + I L +F + + L + +QG VC H
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFD--STVRLWDVEQG--------VC---TH 446
Query: 296 ILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLV 355
L+ Q+ ++++A P +GS D+ V IW+
Sbjct: 447 TLMKHQE------------------------PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
Query: 356 DHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVL 393
+L+ I NA G + DGS VL
Sbjct: 483 SGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 37.4 bits (85), Expect = 0.15
Identities = 39/188 (20%), Positives = 72/188 (38%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN+ + + D+ H +G H V T +Q H +++ N +
Sbjct: 325 DWQNNMTFASCSTDMCIHVCRLGCDHPVKT-----FQGHTNEV------------NAIKW 367
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + L+ HSK + ++ +S TG +L
Sbjct: 368 DPSGMLLASCSDDMTLKIWSMKQDACVHDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W ++G + H + ++ F PD K+V W T +G
Sbjct: 427 SASFDS--TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 485 SLVHSYQG 492
Score = 32.3 bits (72), Expect = 4.7
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Query: 750 DPSIHIWDTET-IKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEK 808
D ++ +WD E + +++K HQ V +V FS DGK LAS D V +W+ + G
Sbjct: 431 DSTVRLWDVEQGVCTHTLMK--HQEPVYSVAFSPDGKYLASGSFD--KYVHIWNTQSGSL 486
Query: 809 LSIARGS 815
+ +G+
Sbjct: 487 VHSYQGT 493
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.1 bits (144), Expect = 2e-08
Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 59/362 (16%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 171 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 856 YIGTLGKNDTMMCAVYGWTEE--MAFSGTSTGDVCIWRDIF-LVKTVKAHDGPVFSMHAL 912
+ K+ T + W + + G+ G IW + L T+ H GP+F++
Sbjct: 230 HDVPSNKDVTSL----DWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 913 EKG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGH 970
+KG ++ G D +WD + + A P++ + +
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA--------------PALD-VDWQNNM 330
Query: 971 ILVGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDL 1027
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 331 TFASCSTDMCIHVCRLGCDHPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSM 388
Query: 1028 SPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV----------- 1076
C+ ++ K +SP G A + N S +M + + + V
Sbjct: 389 KQDACVHDLQAHSKEIYTIKWSPTGPATS---NPNSSIMLASASFDSTVRLWDVEQGVCT 445
Query: 1077 -SFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDI 1135
+ ++ + + FSP GKYLA S D ++ I+N S V +G T I + W+
Sbjct: 446 HTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNA 503
Query: 1136 RG 1137
RG
Sbjct: 504 RG 505
Score = 45.4 bits (106), Expect = 5e-04
Identities = 77/352 (21%), Positives = 133/352 (37%), Gaps = 70/352 (19%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 177 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D+++DG LA D + W + L+ G K IF +K N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI----WTENGNLASTLGQHKGPIFALKWNK-KGN 289
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W M F+ ST D+C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNMTFASCST-DMC-- 340
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + H F H E + G++ L S + LK +++K+ A
Sbjct: 341 --IHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQDACV--- 394
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYL 1010
+ +K ++ +GP T ++P
Sbjct: 395 ------------------HDLQAHSKEIYTIKWSPTGPAT---------------SNPNS 421
Query: 1011 PI-CATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
I A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Score = 44.3 bits (103), Expect = 0.001
Identities = 53/236 (22%), Positives = 92/236 (38%), Gaps = 23/236 (9%)
Query: 214 GALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITV 271
G+ +G +W + + G H IF++ ++G + G D +WD
Sbjct: 253 GSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA------- 305
Query: 272 IDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELW 329
E Q + S + V W+ + + + P QGH E+
Sbjct: 306 -HTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN-EVN 363
Query: 330 ALAVHPTKPLAVTGSDDRSVRIWSLVDHALI--ARCNMEE-------PIRCAAVNADG-I 379
A+ P+ L + SDD +++IWS+ A + + + +E P A N + I
Sbjct: 364 AIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSI 423
Query: 380 HLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
LA D + + V + +E ++ + +SPDG YLA G D V I+
Sbjct: 424 MLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 40.8 bits (94), Expect = 0.013
Identities = 67/352 (19%), Positives = 127/352 (36%), Gaps = 97/352 (27%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL-------------------AGRALLSKK 1559
GH +F+ + P SD G + W L G + S K
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTT 1619
+ S L+ T+LA+ G+ G +W ++ H GP+FA+
Sbjct: 237 DVTS-LDWNSDGTLLAM----------GSYDGFARIWTENGNLASTLGQHKGPIFALKWN 285
Query: 1620 LRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTR 1679
+ +++ G ++ + +WD G+ K
Sbjct: 286 KKGNYVLSAGVDKTTI------IWDAHT----------------------GEAKQQFPFH 317
Query: 1680 NAEIIEVGEKN----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSA 1720
+A ++V +N A+C+ + HV D P+ H PS S
Sbjct: 318 SAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASC 377
Query: 1721 AEDGTVRLWDIADKKMLNKVNLGHAAR--TVCYSPEGDMVAIGMKNGEFIILLVSS---- 1774
++D T+++W + ++ + H+ T+ +SP G + N I+L S+
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQ-AHSKEIYTIKWSPTGPATS----NPNSSIMLASASFDS 432
Query: 1775 -LKIWGKKRD--------RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+++W ++ + ++ + FSPD +YLA GS + V ++ G
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 40.0 bits (92), Expect = 0.023
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 174 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N+DG LA+G DG F + + + K I LK++ G Y
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDG-FARIWTENGNLASTLGQHKGPIFALKWNKKGNYV 291
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 292 LSAGVDKTTI 301
Score = 37.7 bits (86), Expect = 0.11
Identities = 70/338 (20%), Positives = 120/338 (35%), Gaps = 61/338 (18%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + + L+A G + + IW ++ H I L ++ G ++
Sbjct: 237 DVTSLDWNSDGTLLAMGSY--DGFARIWTENG--NLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W N + +C
Sbjct: 293 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ----NNMTFASCSTDMCIHVCRL 346
Query: 183 ALT-PKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGA 235
P + G T ++ I + LA D++T I+ K + +Q A
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQDACVHDLQ-A 399
Query: 236 HAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDH 295
H+ I+++ G AT + I L +F + + L + +QG VC H
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFD--STVRLWDVEQG--------VC---TH 446
Query: 296 ILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLV 355
L+ Q+ ++++A P +GS D+ V IW+
Sbjct: 447 TLMKHQE------------------------PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
Query: 356 DHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVL 393
+L+ I NA G + DGS VL
Sbjct: 483 SGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 37.4 bits (85), Expect = 0.15
Identities = 39/188 (20%), Positives = 72/188 (38%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN+ + + D+ H +G H V T +Q H +++ N +
Sbjct: 325 DWQNNMTFASCSTDMCIHVCRLGCDHPVKT-----FQGHTNEV------------NAIKW 367
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + L+ HSK + ++ +S TG +L
Sbjct: 368 DPSGMLLASCSDDMTLKIWSMKQDACVHDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W ++G + H + ++ F PD K+V W T +G
Sbjct: 427 SASFDS--TVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 485 SLVHSYQG 492
Score = 32.3 bits (72), Expect = 4.7
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Query: 750 DPSIHIWDTET-IKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEK 808
D ++ +WD E + +++K HQ V +V FS DGK LAS D V +W+ + G
Sbjct: 431 DSTVRLWDVEQGVCTHTLMK--HQEPVYSVAFSPDGKYLASGSFD--KYVHIWNTQSGSL 486
Query: 809 LSIARGS 815
+ +G+
Sbjct: 487 VHSYQGT 493
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 58.9 bits (141), Expect = 5e-08
Identities = 84/360 (23%), Positives = 143/360 (39%), Gaps = 55/360 (15%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 173 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 856 YIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW-RDIFLVKTVKAHDGPVFSMHALEK 914
+ K+ T + + + +G+ G IW D L T+ H GP+F++ K
Sbjct: 232 HDVPSNKDVTSLD--WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289
Query: 915 G--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
G ++ G D +WD + + A + + ++N + + S
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAP----ALDVDWQNNTTFASCS------- 338
Query: 973 VGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSP 1029
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 339 ----TDMCIHVCRLGCDRPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392
Query: 1030 SHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV------------S 1077
C+ ++ K +SP G A + N S +M + + + V +
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATS---NPNSNIMLASASFDSTVRLWDIERGVCTHT 449
Query: 1078 FHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRG 1137
++ + + FSP GKYLA S D + I+N S V +G T I + W+ RG
Sbjct: 450 LTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARG 507
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/338 (18%), Positives = 125/338 (36%), Gaps = 69/338 (20%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL------AGRALLSKKGLLSTLEDARM-Q 1571
GH +F+ + P SD G + W L L+ + + D +
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238
Query: 1572 TMLAIAFGANN-LTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGK 1630
+ ++ + N L TG+ G +W + H GP+FA+ + I++ G
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 1631 ERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKN 1690
++ + +WD G+ K +A ++V +N
Sbjct: 299 DKTTI------IWDAHT----------------------GEAKQQFPFHSAPALDVDWQN 330
Query: 1691 ----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSAAEDGTVRLWDI 1731
A+C+ + HV D P+ H PS S ++D T+++W +
Sbjct: 331 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Query: 1732 ADKKMLNKVNLGHAA-RTVCYSPEGDMVAIGMKNGEFIILLVS---SLKIWGKKRD---- 1783
+ ++ + + T+ +SP G A N ++ S ++++W +R
Sbjct: 391 KQEVCIHDLQAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 448
Query: 1784 ----RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+ ++ + FSPD +YLA GS + V ++ G
Sbjct: 449 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Score = 44.3 bits (103), Expect = 0.001
Identities = 52/240 (21%), Positives = 89/240 (37%), Gaps = 23/240 (9%)
Query: 210 LTYSGALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFK 267
L +G+ +G +W + + G H IF++ +G + G D +WD
Sbjct: 251 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA--- 307
Query: 268 PITVIDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCE 325
E Q + S + V W+ + + ++P QGH
Sbjct: 308 -----HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTN 362
Query: 326 GELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEE---------PIRCAAVNA 376
E+ A+ P+ L + SDD +++IWS+ I P A N
Sbjct: 363 -EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 421
Query: 377 DG-IHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
+ I LA D + + + + +E ++ + +SPDG YLA G D V I+
Sbjct: 422 NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 38.5 bits (88), Expect = 0.066
Identities = 74/340 (21%), Positives = 116/340 (34%), Gaps = 59/340 (17%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + L+ATG I D T+ H I L ++ G ++
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ----HKGPIFALKWNRKGNYIL 294
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W SC G
Sbjct: 295 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNTTFASCSTDMCIHVCRLG- 349
Query: 183 ALTPKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGAH 236
P + G T ++ I + LA D++T I+ K I +Q AH
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQEVCIHDLQ-AH 402
Query: 237 AAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHI 296
I+++ G AT + I L +F + + L + ++G VC H
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFD--STVRLWDIERG--------VC---THT 449
Query: 297 LVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356
L Q+ ++++A P +GS D+ V IW+
Sbjct: 450 LTKHQE------------------------PVYSVAFSPDGKYLASGSFDKCVHIWNTQS 485
Query: 357 HALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVR 396
L+ I NA G + DGS VL +R
Sbjct: 486 GNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 38.1 bits (87), Expect = 0.086
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 176 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N +G LA G DG F + D + K I LK++ G Y
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDG-FARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 293
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 294 LSAGVDKTTI 303
Score = 37.7 bits (86), Expect = 0.11
Identities = 74/353 (20%), Positives = 132/353 (37%), Gaps = 72/353 (20%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 179 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D++ +G LA+ D + W + L+ G K IF +K N +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARI----WTEDGNLASTLGQHKGPIFALKWN-RKGN 291
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W F+ ST D+C
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNTTFASCST-DMC-- 342
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + F H E + G++ L S + LK +++K+
Sbjct: 343 --IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQE------ 393
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEV--DKSGPITLLVQGHMEGEVWGLATHP 1008
+ + D + N EI + +GP T ++
Sbjct: 394 --VCIHD---------------LQAHNKEIYTIKWSPTGPATSNPNSNI----------- 425
Query: 1009 YLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
+ A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 426 ---MLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475
Score = 32.7 bits (73), Expect = 3.6
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 750 DPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKL 809
D ++ +WD E L HQ V +V FS DGK LAS D V +W+ + G +
Sbjct: 433 DSTVRLWDIERGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFD--KCVHIWNTQSGNLV 489
Query: 810 SIARGS 815
RG+
Sbjct: 490 HSYRGT 495
Score = 32.0 bits (71), Expect = 6.2
Identities = 37/188 (19%), Positives = 69/188 (36%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN + + D+ H +G V T +Q H +++ N +
Sbjct: 327 DWQNNTTFASCSTDMCIHVCRLGCDRPVKT-----FQGHTNEV------------NAIKW 369
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + + L+ H+K + ++ +S TG +L
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLA 428
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W + G + H + ++ F PD K V W T +G
Sbjct: 429 SASFDS--TVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 487 NLVHSYRG 494
Score = 31.6 bits (70), Expect = 8.0
Identities = 16/82 (19%), Positives = 33/82 (40%), Gaps = 1/82 (1%)
Query: 1689 KNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAART 1748
+ C + H + P++ +A P + S + D V +W+ +++
Sbjct: 442 ERGVCTHTLTKHQE-PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFE 500
Query: 1749 VCYSPEGDMVAIGMKNGEFIIL 1770
VC++ GD V +G +L
Sbjct: 501 VCWNARGDKVGASASDGSVCVL 522
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 58.9 bits (141), Expect = 5e-08
Identities = 84/360 (23%), Positives = 143/360 (39%), Gaps = 55/360 (15%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 173 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 856 YIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW-RDIFLVKTVKAHDGPVFSMHALEK 914
+ K+ T + + + +G+ G IW D L T+ H GP+F++ K
Sbjct: 232 HDVPSNKDVTSLD--WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289
Query: 915 G--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
G ++ G D +WD + + A + + ++N + + S
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAP----ALDVDWQNNTTFASCS------- 338
Query: 973 VGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSP 1029
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 339 ----TDMCIHVCRLGCDRPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392
Query: 1030 SHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV------------S 1077
C+ ++ K +SP G A + N S +M + + + V +
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATS---NPNSNIMLASASFDSTVRLWDIERGVCTHT 449
Query: 1078 FHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRG 1137
++ + + FSP GKYLA S D + I+N S V +G T I + W+ RG
Sbjct: 450 LTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARG 507
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/338 (18%), Positives = 125/338 (36%), Gaps = 69/338 (20%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL------AGRALLSKKGLLSTLEDARM-Q 1571
GH +F+ + P SD G + W L L+ + + D +
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 238
Query: 1572 TMLAIAFGANN-LTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGK 1630
+ ++ + N L TG+ G +W + H GP+FA+ + I++ G
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 1631 ERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKN 1690
++ + +WD G+ K +A ++V +N
Sbjct: 299 DKTTI------IWDAHT----------------------GEAKQQFPFHSAPALDVDWQN 330
Query: 1691 ----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSAAEDGTVRLWDI 1731
A+C+ + HV D P+ H PS S ++D T+++W +
Sbjct: 331 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Query: 1732 ADKKMLNKVNLGHAA-RTVCYSPEGDMVAIGMKNGEFIILLVS---SLKIWGKKRD---- 1783
+ ++ + + T+ +SP G A N ++ S ++++W +R
Sbjct: 391 KQEVCIHDLQAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 448
Query: 1784 ----RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+ ++ + FSPD +YLA GS + V ++ G
Sbjct: 449 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Score = 44.3 bits (103), Expect = 0.001
Identities = 52/240 (21%), Positives = 89/240 (37%), Gaps = 23/240 (9%)
Query: 210 LTYSGALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFK 267
L +G+ +G +W + + G H IF++ +G + G D +WD
Sbjct: 251 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA--- 307
Query: 268 PITVIDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCE 325
E Q + S + V W+ + + ++P QGH
Sbjct: 308 -----HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTN 362
Query: 326 GELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEE---------PIRCAAVNA 376
E+ A+ P+ L + SDD +++IWS+ I P A N
Sbjct: 363 -EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 421
Query: 377 DG-IHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
+ I LA D + + + + +E ++ + +SPDG YLA G D V I+
Sbjct: 422 NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 38.5 bits (88), Expect = 0.066
Identities = 74/340 (21%), Positives = 116/340 (34%), Gaps = 59/340 (17%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + L+ATG I D T+ H I L ++ G ++
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ----HKGPIFALKWNRKGNYIL 294
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W SC G
Sbjct: 295 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNTTFASCSTDMCIHVCRLG- 349
Query: 183 ALTPKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGAH 236
P + G T ++ I + LA D++T I+ K I +Q AH
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQEVCIHDLQ-AH 402
Query: 237 AAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHI 296
I+++ G AT + I L +F + + L + ++G VC H
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFD--STVRLWDIERG--------VC---THT 449
Query: 297 LVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356
L Q+ ++++A P +GS D+ V IW+
Sbjct: 450 LTKHQE------------------------PVYSVAFSPDGKYLASGSFDKCVHIWNTQS 485
Query: 357 HALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVR 396
L+ I NA G + DGS VL +R
Sbjct: 486 GNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 38.1 bits (87), Expect = 0.086
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 176 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N +G LA G DG F + D + K I LK++ G Y
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDG-FARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 293
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 294 LSAGVDKTTI 303
Score = 37.7 bits (86), Expect = 0.11
Identities = 74/353 (20%), Positives = 132/353 (37%), Gaps = 72/353 (20%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 179 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D++ +G LA+ D + W + L+ G K IF +K N +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARI----WTEDGNLASTLGQHKGPIFALKWN-RKGN 291
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W F+ ST D+C
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNTTFASCST-DMC-- 342
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + F H E + G++ L S + LK +++K+
Sbjct: 343 --IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQE------ 393
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEV--DKSGPITLLVQGHMEGEVWGLATHP 1008
+ + D + N EI + +GP T ++
Sbjct: 394 --VCIHD---------------LQAHNKEIYTIKWSPTGPATSNPNSNI----------- 425
Query: 1009 YLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
+ A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 426 ---MLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475
Score = 32.7 bits (73), Expect = 3.6
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 750 DPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKL 809
D ++ +WD E L HQ V +V FS DGK LAS D V +W+ + G +
Sbjct: 433 DSTVRLWDIERGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFD--KCVHIWNTQSGNLV 489
Query: 810 SIARGS 815
RG+
Sbjct: 490 HSYRGT 495
Score = 32.0 bits (71), Expect = 6.2
Identities = 37/188 (19%), Positives = 69/188 (36%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN + + D+ H +G V T +Q H +++ N +
Sbjct: 327 DWQNNTTFASCSTDMCIHVCRLGCDRPVKT-----FQGHTNEV------------NAIKW 369
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + + L+ H+K + ++ +S TG +L
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLA 428
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W + G + H + ++ F PD K V W T +G
Sbjct: 429 SASFDS--TVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 487 NLVHSYRG 494
Score = 31.6 bits (70), Expect = 8.0
Identities = 16/82 (19%), Positives = 33/82 (40%), Gaps = 1/82 (1%)
Query: 1689 KNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAART 1748
+ C + H + P++ +A P + S + D V +W+ +++
Sbjct: 442 ERGVCTHTLTKHQE-PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFE 500
Query: 1749 VCYSPEGDMVAIGMKNGEFIIL 1770
VC++ GD V +G +L
Sbjct: 501 VCWNARGDKVGASASDGSVCVL 522
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 58.9 bits (141), Expect = 5e-08
Identities = 84/360 (23%), Positives = 143/360 (39%), Gaps = 55/360 (15%)
Query: 808 KLSIARGSKDKIFVVKMNPYVPDKLIT-AGIKHMKFWR---KAGGG--------LIGRKG 855
K ++ RG + ++F+ NP V D L + +G + W + GG I G
Sbjct: 224 KATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 856 YIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW-RDIFLVKTVKAHDGPVFSMHALEK 914
+ K+ T + + + +G+ G IW D L T+ H GP+F++ K
Sbjct: 283 HDVPSNKDVTSLD--WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340
Query: 915 G--FVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL 972
G ++ G D +WD + + A + + ++N + + S
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAP----ALDVDWQNNTTFASCS------- 389
Query: 973 VGTKNGEILEVDKSG---PITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSP 1029
+ V + G P+ QGH EV + P + A+ SDD TL+IW +
Sbjct: 390 ----TDMCIHVCRLGCDRPVKTF-QGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443
Query: 1030 SHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLV------------S 1077
C+ ++ K +SP G A + N S +M + + + V +
Sbjct: 444 EVCIHDLQAHNKEIYTIKWSPTGPATS---NPNSNIMLASASFDSTVRLWDIERGVCTHT 500
Query: 1078 FHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRG 1137
++ + + FSP GKYLA S D + I+N S V +G T I + W+ RG
Sbjct: 501 LTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARG 558
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/338 (18%), Positives = 125/338 (36%), Gaps = 69/338 (20%)
Query: 1519 GHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL------AGRALLSKKGLLSTLEDARM-Q 1571
GH +F+ + P SD G + W L L+ + + D +
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 289
Query: 1572 TMLAIAFGANN-LTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGK 1630
+ ++ + N L TG+ G +W + H GP+FA+ + I++ G
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 1631 ERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKN 1690
++ + +WD G+ K +A ++V +N
Sbjct: 350 DKTTI------IWDAHT----------------------GEAKQQFPFHSAPALDVDWQN 381
Query: 1691 ----AACNILVNGHV-----DGPIWGLATH----------PSRDFFLSAAEDGTVRLWDI 1731
A+C+ + HV D P+ H PS S ++D T+++W +
Sbjct: 382 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Query: 1732 ADKKMLNKVNLGHAA-RTVCYSPEGDMVAIGMKNGEFIILLVS---SLKIWGKKRD---- 1783
+ ++ + + T+ +SP G A N ++ S ++++W +R
Sbjct: 442 KQEVCIHDLQAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
Query: 1784 ----RRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
+ ++ + FSPD +YLA GS + V ++ G
Sbjct: 500 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
Score = 44.3 bits (103), Expect = 0.001
Identities = 52/240 (21%), Positives = 89/240 (37%), Gaps = 23/240 (9%)
Query: 210 LTYSGALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFK 267
L +G+ +G +W + + G H IF++ +G + G D +WD
Sbjct: 302 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA--- 358
Query: 268 PITVIDLRETDQGYKGLSVRS--VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCE 325
E Q + S + V W+ + + ++P QGH
Sbjct: 359 -----HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTN 413
Query: 326 GELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEE---------PIRCAAVNA 376
E+ A+ P+ L + SDD +++IWS+ I P A N
Sbjct: 414 -EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNP 472
Query: 377 DG-IHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
+ I LA D + + + + +E ++ + +SPDG YLA G D V I+
Sbjct: 473 NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 38.5 bits (88), Expect = 0.066
Identities = 74/340 (21%), Positives = 116/340 (34%), Gaps = 59/340 (17%)
Query: 63 DIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
D+ SL + L+ATG I D T+ H I L ++ G ++
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ----HKGPIFALKWNRKGNYIL 345
Query: 123 SVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGN 182
S G+D +WD G+ P H+ D+ W SC G
Sbjct: 346 SAGVDK--TTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNTTFASCSTDMCIHVCRLG- 400
Query: 183 ALTPKRGVFGKTGDLQTI------LCLACARDELTYSGALNGDIYVWKGINLIRTIQGAH 236
P + G T ++ I + LA D++T I+ K I +Q AH
Sbjct: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK------IWSMKQEVCIHDLQ-AH 453
Query: 237 AAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHI 296
I+++ G AT + I L +F + + L + ++G VC H
Sbjct: 454 NKEIYTIKWSPTGPATSNPNSNIMLASASFD--STVRLWDIERG--------VC---THT 500
Query: 297 LVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356
L Q+ ++++A P +GS D+ V IW+
Sbjct: 501 LTKHQE------------------------PVYSVAFSPDGKYLASGSFDKCVHIWNTQS 536
Query: 357 HALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVR 396
L+ I NA G + DGS VL +R
Sbjct: 537 GNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 38.1 bits (87), Expect = 0.086
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 18/130 (13%)
Query: 319 IMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHA-------LIARCNME----- 366
+++GH E E++ A +P L +GS D + RIW+L +++ ++ C E
Sbjct: 227 VLRGH-ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
Query: 367 ---EPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTY- 422
+ + N +G LA G DG F + D + K I LK++ G Y
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDG-FARIWTEDGNLASTLGQHKGPIFALKWNRKGNYI 344
Query: 423 LAVGCNDSSV 432
L+ G + +++
Sbjct: 345 LSAGVDKTTI 354
Score = 37.7 bits (86), Expect = 0.11
Identities = 74/353 (20%), Positives = 132/353 (37%), Gaps = 72/353 (20%)
Query: 725 GHDDDILCLTIHPLKDYVATGQVGRDPSIHIWD---------TETIKPLSILKGHHQY-- 773
GH+ ++ +P+ D +A+G D + IW+ T+ + I +G H
Sbjct: 230 GHESEVFICAWNPVSDLLASG--SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 774 --GVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGS-KDKIFVVKMNPYVPD 830
V+++D++ +G LA+ D + W + L+ G K IF +K N +
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARI----WTEDGNLASTLGQHKGPIFALKWN-RKGN 342
Query: 831 KLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW 890
+++AG+ A G ++ + D W F+ ST D+C
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV------DWQNNTTFASCST-DMC-- 393
Query: 891 RDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGS 950
I + + F H E + G++ L S + LK +++K+
Sbjct: 394 --IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGML-LASCSDDMTLKIWSMKQE------ 444
Query: 951 KGLLLEDNPSIRAISLGHGHILVGTKNGEILEV--DKSGPITLLVQGHMEGEVWGLATHP 1008
+ + D + N EI + +GP T ++
Sbjct: 445 --VCIHD---------------LQAHNKEIYTIKWSPTGPATSNPNSNI----------- 476
Query: 1009 YLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLND 1061
+ A+ S D T+R+WD+ C + K ++ FSPDGK LA G D
Sbjct: 477 ---MLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
Score = 32.7 bits (73), Expect = 3.6
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 750 DPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKL 809
D ++ +WD E L HQ V +V FS DGK LAS D V +W+ + G +
Sbjct: 484 DSTVRLWDIERGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFD--KCVHIWNTQSGNLV 540
Query: 810 SIARGS 815
RG+
Sbjct: 541 HSYRGT 546
Score = 32.0 bits (71), Expect = 6.2
Identities = 37/188 (19%), Positives = 69/188 (36%), Gaps = 30/188 (15%)
Query: 1383 DCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVAT 1442
D +NN + + D+ H +G V T +Q H +++ N +
Sbjct: 378 DWQNNTTFASCSTDMCIHVCRLGCDRPVKT-----FQGHTNEV------------NAIKW 420
Query: 1443 GQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK---------LLL 1493
G + ++ IW + + L+ H+K + ++ +S TG +L
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLA 479
Query: 1494 SVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFW-TLAG 1552
S D T+ +W + G + H + ++ F PD K V W T +G
Sbjct: 480 SASFDS--TVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
Query: 1553 RALLSKKG 1560
+ S +G
Sbjct: 538 NLVHSYRG 545
Score = 31.6 bits (70), Expect = 8.0
Identities = 16/82 (19%), Positives = 33/82 (40%), Gaps = 1/82 (1%)
Query: 1689 KNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAART 1748
+ C + H + P++ +A P + S + D V +W+ +++
Sbjct: 493 ERGVCTHTLTKHQE-PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFE 551
Query: 1749 VCYSPEGDMVAIGMKNGEFIIL 1770
VC++ GD V +G +L
Sbjct: 552 VCWNARGDKVGASASDGSVCVL 573
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,545,073
Number of Sequences: 37866
Number of extensions: 3611394
Number of successful extensions: 13553
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 9136
Number of HSP's gapped (non-prelim): 3335
length of query: 1977
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1860
effective length of database: 13,817,196
effective search space: 25699984560
effective search space used: 25699984560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.