Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 34304379
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34304379 inversin isoform b [Homo sapiens]
(895 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34304379 inversin isoform b [Homo sapiens] 1810 0.0
gi|34304381 inversin isoform a [Homo sapiens] 1474 0.0
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 215 2e-55
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 207 4e-53
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 201 2e-51
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 199 7e-51
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 199 7e-51
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 199 7e-51
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 199 7e-51
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 199 7e-51
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 196 8e-50
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 193 5e-49
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 193 5e-49
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 193 5e-49
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 193 7e-49
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 154 5e-37
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 149 9e-36
gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens] 148 2e-35
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 142 1e-33
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 139 9e-33
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 136 8e-32
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 135 2e-31
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 135 2e-31
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 131 2e-30
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 131 2e-30
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 127 6e-29
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 124 3e-28
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 123 7e-28
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 120 4e-27
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 120 7e-27
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 1810 bits (4687), Expect = 0.0
Identities = 895/895 (100%), Positives = 895/895 (100%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV
Sbjct: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
Query: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL
Sbjct: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
Query: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
Query: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA
Sbjct: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA 480
QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA
Sbjct: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA 480
Query: 481 DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI 540
DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI
Sbjct: 481 DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI 540
Query: 541 QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE 600
QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE
Sbjct: 541 QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE 600
Query: 601 NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG 660
NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG
Sbjct: 601 NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG 660
Query: 661 SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP 720
SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP
Sbjct: 661 SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP 720
Query: 721 SVEKSRELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDV 780
SVEKSRELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDV
Sbjct: 721 SVEKSRELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDV 780
Query: 781 DRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHE 840
DRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHE
Sbjct: 781 DRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHE 840
Query: 841 GKIHHPTRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP 895
GKIHHPTRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP
Sbjct: 841 GKIHHPTRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP 895
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 1474 bits (3817), Expect = 0.0
Identities = 726/726 (100%), Positives = 726/726 (100%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV
Sbjct: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
Query: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL
Sbjct: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
Query: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
Query: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA
Sbjct: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA 480
QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA
Sbjct: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA 480
Query: 481 DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI 540
DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI
Sbjct: 481 DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI 540
Query: 541 QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE 600
QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE
Sbjct: 541 QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE 600
Query: 601 NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG 660
NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG
Sbjct: 601 NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG 660
Query: 661 SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP 720
SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP
Sbjct: 661 SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP 720
Query: 721 SVEKSR 726
SVEKSR
Sbjct: 721 SVEKSR 726
Score = 339 bits (870), Expect = 6e-93
Identities = 169/169 (100%), Positives = 169/169 (100%)
Query: 727 ELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQE 786
ELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQE
Sbjct: 897 ELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQE 956
Query: 787 STALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHP 846
STALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHP
Sbjct: 957 STALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHP 1016
Query: 847 TRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP 895
TRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP
Sbjct: 1017 TRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP 1065
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 215 bits (547), Expect = 2e-55
Identities = 174/576 (30%), Positives = 270/576 (46%), Gaps = 52/576 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA + L+V N A + + + G++PL + R + L++ G +++
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D T LH+AA+ G+ + L T A+ + + M PLHL + C LL
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS-- 368
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
+ E+DT DK +T LH +A N E +KLL ++ D G+ PLH+AA A
Sbjct: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA------A 422
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA---DGNVTVVD---------------- 238
CI T + +N D GRT LH+A A D N T++
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
Query: 239 --------VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290
N + D +H+AA GH Q + LLLER SG SDS GA
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS-GA 541
Query: 291 T--PLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
T PLH AA + + ++V L+ D D +GRT+ AA KG + + +++ + I
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 349 DI--NMADKYGGTALHAAALSGHVSTVKLLLE---NNAQVDATDVMKHTPLFRACEMGHK 403
+ N+ + T LHA+ ++GH ++LLLE N VD D TPL A GH
Sbjct: 602 FVKDNVTKR---TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHI 658
Query: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463
D + L++ A VD VD G + LH + G+ + Q+L+E +++ +D GRTPL A
Sbjct: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
Query: 464 AYGGYINCMAVLME---NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN 520
A G+ ++ L++ + D +D +G T LHW+C NG + I++LL+ F + N
Sbjct: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
Query: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556
+TPL A++ + +L SI + +D
Sbjct: 779 ---PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Score = 188 bits (478), Expect = 2e-47
Identities = 153/576 (26%), Positives = 262/576 (45%), Gaps = 46/576 (7%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
++K+E++ S + +H AA GD ++ LI+ + + K++ + TPL V +
Sbjct: 3 IHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASRS 61
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
+ L+K ADVN D + +T LH+AA + ++++ ++ D T LH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
+ + + LLL A ++ DK + ALHW+AY + + V LLI H + + D
Sbjct: 122 AALNGHVEMVNLLLAKGA--NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
+G PLH AA++ ++ V+ +L+ +N G T LH A +G VV+ L
Sbjct: 180 KGYTPLHAAASN---GQINVVKHLLNLGVEIDEIN---VYGNTALHIACYNGQDAVVNEL 233
Query: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300
Y N+ +N TPLH+AA H + LL N + G +PLH A
Sbjct: 234 IDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292
Query: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS----------------- 343
+ +++ D D +G T AA G + ++ T+ +
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
Query: 344 --------------LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
L S +I+ DK+G T LHAAA G+V +KLL + A D
Sbjct: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412
Query: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449
TPL A H I+TL+ GA V+ D G + LH+AA + D + ++ N +
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILGNAHDN 471
Query: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
+ + R + A C+ L++N+A+P+I+DKEG ++H++ G+ ++LLL
Sbjct: 472 SEELERARELKEKEA----TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Query: 510 DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
+ + ++ +PL A H+ ++ +L+
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Score = 182 bits (462), Expect = 1e-45
Identities = 144/499 (28%), Positives = 225/499 (45%), Gaps = 81/499 (16%)
Query: 67 LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126
L+ DVN D +RT LH+AA G+ ++LL+ A KD +TPLH RS
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186
+ + +L+K A +V+ +DKN QT LH +A + +++I S++ + D G+ L
Sbjct: 62 EEAVQVLIKHSA--DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 187 HWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246
H AA +G+V +V++L + +
Sbjct: 120 HHAA---------------------------------------LNGHVEMVNLLLA-KGA 139
Query: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
NI ++D R LHWAA +GH +V LL+ T D +G TPLH AA + VK
Sbjct: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC-KDKKGYTPLHAAASNGQINVVK 198
Query: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI------------------ 348
L D+ ++ G T+ A G D V+ ++ +++
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
Query: 349 --------------DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394
D+N+ K G + LH A+ G + + L++N ++D D +TPL
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPL 318
Query: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSL--LHWAALGGNADVCQILIENKINPNVQ 452
A GH+ +I TL GA D HS+ LH AAL ++D C+ L+ + +
Sbjct: 319 HVAARYGHELLINTLRTSGA--DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTP 376
Query: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
D GRT L AA GG + C+ +L + AD + +DK GRT LH++ N + I+ L+
Sbjct: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Query: 513 AFPNQMENNEERYTPLDYA 531
A N E ++ T L YA
Sbjct: 437 A--NVNETDDWGRTALHYA 453
Score = 173 bits (439), Expect = 6e-43
Identities = 151/556 (27%), Positives = 245/556 (44%), Gaps = 93/556 (16%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+HAAA G+ + +L+ + A K+D+ GRTPL Y C + L+ GA+VN+T
Sbjct: 384 LHAAAAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNET 442
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D RTALH AA R +L N EE+ + CL LL+
Sbjct: 443 DDWGRTALHYAAASDMDRNKTILGNAHDN-----SEELERARELKEKEATLCLEFLLQND 497
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG---KIPLHWAANHKD 194
A + +DK ++H++A Y + + ++LL++ +N G + + K PLH AA +
Sbjct: 498 ANPSI--RDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGH 554
Query: 195 PSAVHTV-RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
A+ + + ++D L+ +D +GRT L A G+ V+ L + +I DN
Sbjct: 555 HQALEVLLQSLVD-------LDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDN 606
Query: 254 LF-RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
+ RTPLH + + GH + LLLE +P
Sbjct: 607 VTKRTPLHASVINGHTLCLRLLLE-------------------------------IADNP 635
Query: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372
D D +G+T M A G D + +L ++++D D G TALH ++GH
Sbjct: 636 EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT--VDILGCTALHRGIMTGHEEC 693
Query: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD---LVDQDGHSLLHW 429
V++LLE + D TPL A GH + L++ + D G++ LHW
Sbjct: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753
Query: 430 AALGGNADVCQILIENKI------NP----------------------------NVQDYA 455
A GN + ++L+E K NP + +D
Sbjct: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
Query: 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFP 515
GRTPL+ AA+ ++ C+ +L+ ++A N D G+TAL + NG A+ +L++ +A
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQA 872
Query: 516 NQMENNEERYTPLDYA 531
+ +++ TPL A
Sbjct: 873 DLTVKDKDLNTPLHLA 888
Score = 140 bits (352), Expect = 7e-33
Identities = 124/424 (29%), Positives = 195/424 (45%), Gaps = 28/424 (6%)
Query: 16 SQVHAAAVNGDKGALQRLIVG-NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
+ +H AA G + L+ L+ NS ++ + ++PL + LL++ D+
Sbjct: 509 NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
Query: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-LEEMTPLHLTTRHRSPKCLALL 133
+ D RTAL LAA KG+ ++ L+ A+ KD + + TPLH + + CL LL
Sbjct: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Query: 134 LKFMA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA--A 190
L+ P VD +D QT L + Y + + V LL++ ++N+ D+ G LH
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
Query: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT----VVDVLTSYESC 246
H++ C+ E + +D GRTPLH+A A G+ T ++ + S E C
Sbjct: 689 GHEE--------CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
DN TPLHWA G+ + +LLE+ + TPLH A ++
Sbjct: 741 CFK--DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCAS 796
Query: 307 VFLK--HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAA 364
+ L S+ D +GRT AA +D V L L+ +N D G TAL A
Sbjct: 797 LLLGAIDSSIVSCRDDKGRTPLRAAAF--ADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854
Query: 365 ALSGHVSTVKLLLENNAQVDAT--DVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422
A +G V +L+ N+AQ D T D +TPL AC GH+ ++ L+++
Sbjct: 855 AENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Query: 423 GHSL 426
++L
Sbjct: 914 NNAL 917
Score = 125 bits (314), Expect = 2e-28
Identities = 89/303 (29%), Positives = 139/303 (45%), Gaps = 39/303 (12%)
Query: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
++ + D+ RTPLH AA LG A+I+ LL+ + + D+ TPLH A S E V+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLI-LSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
Query: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366
V +KH + D+N DK T LH AA
Sbjct: 67 VLIKHSA-----------------------------------DVNARDKNWQTPLHVAAA 91
Query: 367 SGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL 426
+ V ++++ + V+ +D T L A GH +++ L+ GA ++ D+
Sbjct: 92 NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA 151
Query: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
LHWAA G+ DV +LI + +D G TPL AA G IN + L+ + + +
Sbjct: 152 LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211
Query: 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV-IQFMLE 545
G TALH +C NG + L+D+ A NQ NN +TPL +A + ++ ++
Sbjct: 212 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGALCLELLVN 269
Query: 546 HGA 548
+GA
Sbjct: 270 NGA 272
Score = 90.5 bits (223), Expect = 6e-18
Identities = 54/174 (31%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Query: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
+L+ V+ D K TPL A +G ++I+ LI GARV+ D + LH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494
+ + Q+LI++ + N +D +TPL AA + C V++ + N+ D+ GRTALH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+ NG+++ + LLL A N + + R L +A +V+ ++ HGA
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGA 172
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 207 bits (527), Expect = 4e-53
Identities = 186/651 (28%), Positives = 291/651 (44%), Gaps = 41/651 (6%)
Query: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
R ++ N A ++ D GRT L + LD + L+ GAD+ D T L LAA++
Sbjct: 529 RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQ 588
Query: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
G+ + + L+ AN D + T L + ++ LL A +VD D + +T
Sbjct: 589 GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL--YAGVKVDCADADSRT 646
Query: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAP 209
AL +A+ + + V L++H + + D EG+ L AA H++ V +LD
Sbjct: 647 ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE-----IVEHLLDHGA 701
Query: 210 TESLLNWQDYEGRTPLHFAV-----ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 264
+N +D +GRT L A + G+ +VV +L + D TPL AA
Sbjct: 702 E---VNHEDVDGRTALSVAALCVPASKGHASVVSLLID-RGAEVDHCDKDGMTPLLVAAY 757
Query: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
GH +V LLLE + +D+ G TPL AA A V L + D D EGRT
Sbjct: 758 EGHVDVVDLLLEGG-ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
Query: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384
A+ +G+ +V+RT+L +D N D G T LH AA GH + L+E A+ +
Sbjct: 817 VLSIASAQGNVEVVRTLLD--RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
D P A + GH D +Q L++ + +D DG + L AAL G+ D+ ++L
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
Query: 445 NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504
+ + N +D GR L A + +EN A+ D EGRTALH SC G+++
Sbjct: 935 HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 505 IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQA 564
+++L+ + A N +N E+ + L A +V+Q ++EHGA+ A A
Sbjct: 995 VQVLIAYHADVNAADN--EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
Query: 565 VYKGYKVRKAFRDRKNLLMKH-------EQLRKDA--AAKKREEENKRKEAEQQKGRRSP 615
+G+ D +L++H +Q + A A K K E+ G S
Sbjct: 1053 AQEGH------IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY-GASSL 1105
Query: 616 DSCRPQALPCLPS--TQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGG 664
+ C P + + Q + S+ K +G+ G RG P G
Sbjct: 1106 NGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNG 1156
Score = 114 bits (286), Expect = 3e-25
Identities = 79/251 (31%), Positives = 126/251 (50%), Gaps = 9/251 (3%)
Query: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362
++++ L + + + D GRT AA GS DV+ ++S +D++I D +G T L
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIE--DAHGHTPLT 583
Query: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422
AA GH V L+ A ++ TD T L A GH +V+ L+ G +VD D D
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
+ L AA GG+ D+ L+++ N D GRT L AAY G+ + L+++ A+
Sbjct: 644 SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703
Query: 483 NIQDKEGRTALHWS-----CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537
N +D +GRTAL + + G+ + LL+D A + + ++ TPL A
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD--KDGMTPLLVAAYEGHV 761
Query: 538 EVIQFMLEHGA 548
+V+ +LE GA
Sbjct: 762 DVVDLLLEGGA 772
Score = 112 bits (279), Expect = 2e-24
Identities = 83/264 (31%), Positives = 129/264 (48%), Gaps = 14/264 (5%)
Query: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370
H + +DD RTS + +D +RT+L + +N D G T L AA SG +
Sbjct: 506 HVNSEDD-----RTSCIVRQALEREDSIRTLLD--NGASVNQCDSNGRTLLANAAYSGSL 558
Query: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
V LL+ A ++ D HTPL A GH V+ LI GA ++ DQDG + L A
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
Query: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
A GG+ +V L+ + + D RT L+ AA+GG+ + + L+++ A+ N D EGR
Sbjct: 619 AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
Query: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALL----GERH-EVIQFMLE 545
TAL + G+ + ++ LLD A N + + T L A L + H V+ +++
Sbjct: 679 TALIAAAYMGHREIVEHLLDHGAEVN--HEDVDGRTALSVAALCVPASKGHASVVSLLID 736
Query: 546 HGALSIAAIQDIAAFKIQAVYKGY 569
GA +D + A Y+G+
Sbjct: 737 RGAEVDHCDKDGMTPLLVAAYEGH 760
Score = 59.7 bits (143), Expect = 1e-08
Identities = 56/215 (26%), Positives = 93/215 (43%), Gaps = 8/215 (3%)
Query: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEM---GHKDVIQTLIKGGAR 415
T L A + H+ L LE A++ + TP+ + ++V+Q L+K GA
Sbjct: 448 TPLEAQEFALHLINSNLQLET-AELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAH 506
Query: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
V+ D ++ A D + L++N + N D GRT L AAY G ++ + +L
Sbjct: 507 VNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535
+ AD I+D G T L + G+ + L+ A N +++ +T L A G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQDGWTALRSAAWGG 622
Query: 536 RHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYK 570
EV+ +L G A D A + G++
Sbjct: 623 HTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 201 bits (512), Expect = 2e-51
Identities = 169/584 (28%), Positives = 259/584 (44%), Gaps = 62/584 (10%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+HAAA G+ L L+ + L+ + D+FGRTPL Y CA L+ AGA VN+
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLR-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEA 485
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D + LH AA YR D EE PL + R + CL LL
Sbjct: 486 DCKGCSPLHYAAASDTYR-----RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP---LHWAANHKD 194
A + +D+ TA+H++A Y N ++++LL++ N + DVE IP LH AA +
Sbjct: 541 A--DPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGH 597
Query: 195 PSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254
A+ T+ A T L+ +D++GRT L A G+ V+VLT++ + +
Sbjct: 598 CEALKTL------AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Query: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKHP 312
TPLH AA GH +HLL++ + I D+ G TPL A + + V + L+
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
Query: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372
S D +DL GRT+ A G +D L +L D + D G T +H A+ GH +
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLD--HDAFVLCRDFKGRTPIHLASACGHTAV 769
Query: 373 VKLLLENNAQVD----ATDVMKHTPLFRACEMGHKDVIQTLIK----------------- 411
++ LL+ D D ++P+ A GH+D ++ L++
Sbjct: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHC 829
Query: 412 -----------------GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454
G V+ D G + LH AA N ++L++++ N D+
Sbjct: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH 889
Query: 455 AGRTPLQCAAYGGYINCMAVLM-ENNADPNIQDKEGRTALHWSCNNGYLD-AIKLLLDFA 512
GRT L AA G + L+ AD + D+ TALH +C+ G+ A+ +L +
Sbjct: 890 TGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQ 949
Query: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556
N PL A V+Q +L HGA +A ++
Sbjct: 950 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEE 993
Score = 174 bits (441), Expect = 3e-43
Identities = 152/539 (28%), Positives = 234/539 (43%), Gaps = 99/539 (18%)
Query: 51 PLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQK 110
PL+ + + ++ +LL ++N D +RT LH AA G+ ++LLL AN K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 111 DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK 170
D +TPLH R+ K L LLL A +V+ +DK QT LH +A
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSA--DVNARDKLWQTPLHVAA------------- 115
Query: 171 HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230
+N E PL + N D S GR+ LH AV
Sbjct: 116 --ANRATKCAEALAPLLSSLNVADRS------------------------GRSALHHAVH 149
Query: 231 DGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290
G++ V++L + + ++ D R PLHWAA LGH +++ LL+ R + D +G
Sbjct: 150 SGHLETVNLLLN-KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG-ADLGCKDRKGY 207
Query: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI-- 348
LH AA S E VK L+ + D+ + G T+ A G D V +++ +++
Sbjct: 208 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 349 ------------------------------DINMADKYGGTALHAAALSGHVSTVKLLLE 378
D+N K G + LH AA+ G + ++L++
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL--LHWAALGGNA 436
N +++D D +TPL A GH+ +I TL+ GA D + H + LH A L G +
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA--DTARRGIHDMFPLHLAVLFGFS 385
Query: 437 DVCQILIEN------------------KINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN 478
D C+ L+ + + N D GRT L AA GG + C+ +L+ +
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
Query: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537
AD +DK GRT LH++ NG L+ A N E + + +PL YA + +
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN--EADCKGCSPLHYAAASDTY 502
Score = 167 bits (423), Expect = 4e-41
Identities = 149/530 (28%), Positives = 231/530 (43%), Gaps = 36/530 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA N + L S+L + D+ GR+ L + V + L+ + LL GA +N
Sbjct: 111 LHVAAANRATKCAEALAPLLSSL-NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC 169
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D +R LH AA G+ +KLL+ R A+ KD + LH + + LL+
Sbjct: 170 DKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A E+D + TALH + Y L+ +N+ P+ +G PLH AA +
Sbjct: 230 A--EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA-----VS 282
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
+ C+ + +N+Q EG++PLH A G T +L S I D T
Sbjct: 283 TNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS-EIDCADKFGNT 341
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH AA GH ++ L+ N + T PLH A F++ + L +
Sbjct: 342 PLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL--- 397
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
+ + ++ VL + DIN D G T LHAAA G+V + LLL
Sbjct: 398 --------YSIVSSLSNEHVL------SAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
+ A + D TPL A G TL+ GA V+ D G S LH+AA
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
Query: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
+ P+ D PL+ + C+ L++N ADP+++D++G TA+H++
Sbjct: 504 RAE-----PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA 558
Query: 498 NNGYLDAIKLLLDFAAFPNQMENNEER--YTPLDYALLGERHEVIQFMLE 545
G ++LLL+ + N +E+ E +PL A E ++ + E
Sbjct: 559 AYGNRQNLELLLEMSF--NCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Score = 159 bits (402), Expect = 1e-38
Identities = 160/647 (24%), Positives = 256/647 (39%), Gaps = 166/647 (25%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AAV+ + L+V N A + + + G++PL + R + L++ G++++
Sbjct: 276 LHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK-- 135
D T LH+AA+ G+ + L+T A+ ++ + +M PLHL C LL
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Query: 136 --------------FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE 181
A +++T D +T LH +A N E + LL+ +++ D
Sbjct: 396 QLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKF 455
Query: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
G+ PLH+AA A + +C + + +N D +G +PLH+A A + T
Sbjct: 456 GRTPLHYAA------ANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHT 509
Query: 242 --SYES-------------------------CNITSYDNLFRTPLHWAALLGHAQIVHLL 274
S+++ + + D T +H+AA G+ Q + LL
Sbjct: 510 PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
Query: 275 LE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM- 327
LE + TIP +PLH AA + E +K + D D +GRT+
Sbjct: 570 LEMSFNCLEDVESTIP-----VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFL 624
Query: 328 ----------------------------W-----AAGKGSDDVLRTMLSLKSDIDI-NMA 353
W AA G D L ++ DI ++
Sbjct: 625 ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM 684
Query: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFR----ACE---------- 399
D YG T L A ++GHV V LLLE + DA D+ T L R CE
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744
Query: 400 -------------------MGHKDVIQTLIKGGARVDL----VDQDGHSLLHWAALGGNA 436
GH V++TL++ D VD G+S +HWA+ G+
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804
Query: 437 DVCQILIE---------NKINP-------------------------NVQDYAGRTPLQC 462
D ++L+E N P N +D GRTPL
Sbjct: 805 DCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHA 864
Query: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
AA+ ++ + +L+++ A+ N D GRTAL + NG A++ LL
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
Score = 147 bits (370), Expect = 6e-35
Identities = 142/520 (27%), Positives = 239/520 (45%), Gaps = 65/520 (12%)
Query: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE---MTPLH 119
C + LL GAD + D TA+H AA GN + ++LLL N ++ D+E ++PLH
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE-DVESTIPVSPLH 590
Query: 120 LTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
L + + L L + + +D +D +TAL + + E V++L H ++ I +
Sbjct: 591 LAAYNGHCEALKTLAETLV--NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 180 VEGK-IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238
+ K PLH AA ++H ++D+ + + D G+TPL A+ +G+V V
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHL---LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
Query: 239 VL-----------------------TSYESCNITSYDN---------LFRTPLHWAALLG 266
+L T E C D+ RTP+H A+ G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Query: 267 HAQIVHLLLERNKSGTIPSDS----QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEG 322
H ++ LL+ S T P D+ G +P+H+A+ + + +++ L+H S LEG
Sbjct: 766 HTAVLRTLLQAALS-TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF---SYLEG 821
Query: 323 R--TSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
T A D +L +N D G T LHAAA + +VS +++LL++
Sbjct: 822 NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVC 439
A+V+ATD T L A E G ++ L+ +G A + ++D++ ++ LH A G+ + C
Sbjct: 882 AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH-EKC 940
Query: 440 QILIENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT-ALH 494
++I + N + A + PL AA G + + L+ + A D+EG T AL
Sbjct: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALA 1000
Query: 495 WSCNNGYLDAIKLLLD-FAAFPNQMENNEERYTPLDYALL 533
+ N D + L+L FP ++ +P ++LL
Sbjct: 1001 CAPNKDVADCLALILSTMKPFP-----PKDAVSPFSFSLL 1035
Score = 122 bits (307), Expect = 1e-27
Identities = 102/327 (31%), Positives = 157/327 (48%), Gaps = 9/327 (2%)
Query: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283
PL A+ +V V L S + NI D RTPLH AA +G I+ LLL + +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLL-MSGANVN 68
Query: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343
D+ TPLH AA S + + + L H + + D +T AA + +
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 344 LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHK 403
L S + N+AD+ G +ALH A SGH+ TV LLL A ++ D + PL A +GH
Sbjct: 129 LLSSL--NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186
Query: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463
+V++ L+ GA + D+ G+ LLH AA G +V + L+ + + G T L A
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Query: 464 AYGGYINCMAVLMENNADPNIQDKEGRTALHWSC--NNGYLDAIKLLLDFAAFPNQMENN 521
Y G L+ A+ N + +G T LH + NG L ++LL++ A N +
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY--QS 303
Query: 522 EERYTPLDYALLGERHEVIQFMLEHGA 548
+E +PL A + R Q ++++G+
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGS 330
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 199 bits (507), Expect = 7e-51
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 224
Query: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 278
Query: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 279 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 336
Query: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 394
Query: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 395 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 454
Query: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 572
Query: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
L A + V + +LE A AA
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAA 598
Score = 196 bits (499), Expect = 6e-50
Identities = 163/564 (28%), Positives = 258/564 (45%), Gaps = 48/564 (8%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA N D +++ N D + G TPL + L+ A LL GA VN T
Sbjct: 210 LHIAARNDDTRTAA-VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ T LH+A+++GN ++LLL R A K +E+TPLH R+ + +LL
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
AP + + KN + +H +A ++ + V+LL+++D+ I ++ PLH AA H
Sbjct: 329 AP--IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA-HCGHHR 385
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
V V A P LN G TPLH A +V V+++L +I + T
Sbjct: 386 VAKVLLDKGAKPNSRALN-----GFTPLHIACKKNHVRVMELLLK-TGASIDAVTESGLT 439
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH A+ +GH IV LL+R S + S+ + TPLH AA++ E K L++ + +
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
+ +T AA G ++++ L L+++ + N+A G T LH AA GHV TV LL
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVK--LLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
Query: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
E A TPL A + G V + L++ A + ++G + LH A N D
Sbjct: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616
Query: 438 VCQILIENKINP---------------------------------NVQDYAGRTPLQCAA 464
+ ++L+ +P N + G TPL AA
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G+ +A+L+ A+ N+ +K G T LH G++ +L+ +
Sbjct: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRMG 734
Query: 525 YTPLDYALLGERHEVIQFMLEHGA 548
YTPL A ++++F+L+H A
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQA 758
Score = 186 bits (473), Expect = 6e-47
Identities = 150/527 (28%), Positives = 234/527 (44%), Gaps = 37/527 (7%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 309 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 367
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN------ 191
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA
Sbjct: 428 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 485
Query: 192 ---------------HKDPSAVHTVRCILDAAPTESLL------NWQDYEGRTPLHFAVA 230
D + +H I + LL N G TPLH A
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 545
Query: 231 DGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290
+G+V V L E+ F TPLH AA G ++ LLLER+ + G
Sbjct: 546 EGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNA-AGKNGL 603
Query: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDI 350
TPLH A N + VK+ L G T AA + +V R++L
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA-- 661
Query: 351 NMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLI 410
N G T LH AA GH V LLL A + + TPL + GH V LI
Sbjct: 662 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721
Query: 411 KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 470
K G VD + G++ LH A+ GN + + L++++ + N + G +PL AA G+ +
Sbjct: 722 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 781
Query: 471 CMAVLMENNADPNIQDKEGRTALHWSCNNGYL---DAIKLLLDFAAF 514
+ +L++N A PN +G T L + GY+ D +K++ D +F
Sbjct: 782 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSF 828
Score = 182 bits (461), Expect = 2e-45
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 53/581 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 115 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 173
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 174 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 227
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 284
Query: 198 VHTVRCILDAAP------------------------TESLLNW------QDYEGRTPLHF 227
V VR +LD +E LL+ + G +P+H
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
Query: 228 AVADGNVTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
A ++ V +L Y++ + + D+L TPLH AA GH ++ +LL++ G P+
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK---GAKPNS 399
Query: 287 S--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
G TPLH A + N +++ LK + D G T A+ G +++ +L
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-- 457
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKD 404
+ N+++ T LH AA +GH K LL+N A+V+A TPL A +GH +
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 464
+++ L++ A +L GH+ LH AA G+ + L+E + + G TPL AA
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G + +L+E +A PN K G T LH + ++ LD +KLLL P+ N
Sbjct: 578 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--G 635
Query: 525 YTPLDYALLGERHEVIQFMLEHGALSIA-AIQDIAAFKIQA 564
YTPL A + EV + +L++G + A ++Q + + A
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Score = 92.0 bits (227), Expect = 2e-18
Identities = 74/257 (28%), Positives = 117/257 (45%), Gaps = 33/257 (12%)
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+ TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 44 DAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 101
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V +
Sbjct: 102 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCM---------------------------- 472
L+EN N NV G TPL A G+ N +
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 221
Query: 473 -AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL A
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIA 279
Query: 532 LLGERHEVIQFMLEHGA 548
+++ +L+ GA
Sbjct: 280 SRRGNVIMVRLLLDRGA 296
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 199 bits (507), Expect = 7e-51
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
Query: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
Query: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
Query: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
Query: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
Query: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
L A + V + +LE A AA
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 184 bits (466), Expect = 4e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
Query: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
Query: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
Query: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
K + +S +PC +P T + S + SK+
Sbjct: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
Score = 182 bits (461), Expect = 2e-45
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 53/581 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
Query: 198 VHTVRCILDAAP------------------------TESLLNW------QDYEGRTPLHF 227
V VR +LD +E LL+ + G +P+H
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 228 AVADGNVTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
A ++ V +L Y++ + + D+L TPLH AA GH ++ +LL++ G P+
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK---GAKPNS 366
Query: 287 S--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
G TPLH A + N +++ LK + D G T A+ G +++ +L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-- 424
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKD 404
+ N+++ T LH AA +GH K LL+N A+V+A TPL A +GH +
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 464
+++ L++ A +L GH+ LH AA G+ + L+E + + G TPL AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G + +L+E +A PN K G T LH + ++ LD +KLLL P+ N
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--G 602
Query: 525 YTPLDYALLGERHEVIQFMLEHGALSIA-AIQDIAAFKIQA 564
YTPL A + EV + +L++G + A ++Q + + A
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
+ L+EN N NV G TPL A G+ N +
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
Query: 530 YALLGERHEVIQFMLEHGA 548
A +++ +L+ GA
Sbjct: 245 IASRRGNVIMVRLLLDRGA 263
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 199 bits (507), Expect = 7e-51
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
Query: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
Query: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
Query: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
Query: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
Query: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
L A + V + +LE A AA
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 184 bits (466), Expect = 4e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
Query: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
Query: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
Query: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
K + +S +PC +P T + S + SK+
Sbjct: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
Score = 182 bits (461), Expect = 2e-45
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 53/581 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
Query: 198 VHTVRCILDAAP------------------------TESLLNW------QDYEGRTPLHF 227
V VR +LD +E LL+ + G +P+H
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 228 AVADGNVTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
A ++ V +L Y++ + + D+L TPLH AA GH ++ +LL++ G P+
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK---GAKPNS 366
Query: 287 S--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
G TPLH A + N +++ LK + D G T A+ G +++ +L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-- 424
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKD 404
+ N+++ T LH AA +GH K LL+N A+V+A TPL A +GH +
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 464
+++ L++ A +L GH+ LH AA G+ + L+E + + G TPL AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G + +L+E +A PN K G T LH + ++ LD +KLLL P+ N
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--G 602
Query: 525 YTPLDYALLGERHEVIQFMLEHGALSIA-AIQDIAAFKIQA 564
YTPL A + EV + +L++G + A ++Q + + A
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
+ L+EN N NV G TPL A G+ N +
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
Query: 530 YALLGERHEVIQFMLEHGA 548
A +++ +L+ GA
Sbjct: 245 IASRRGNVIMVRLLLDRGA 263
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 199 bits (507), Expect = 7e-51
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
Query: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
Query: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
Query: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
Query: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
Query: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
L A + V + +LE A AA
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 184 bits (466), Expect = 4e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
Query: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
Query: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
Query: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
K + +S +PC +P T + S + SK+
Sbjct: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
Score = 182 bits (461), Expect = 2e-45
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 53/581 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
Query: 198 VHTVRCILDAAP------------------------TESLLNW------QDYEGRTPLHF 227
V VR +LD +E LL+ + G +P+H
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 228 AVADGNVTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
A ++ V +L Y++ + + D+L TPLH AA GH ++ +LL++ G P+
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK---GAKPNS 366
Query: 287 S--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
G TPLH A + N +++ LK + D G T A+ G +++ +L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-- 424
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKD 404
+ N+++ T LH AA +GH K LL+N A+V+A TPL A +GH +
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 464
+++ L++ A +L GH+ LH AA G+ + L+E + + G TPL AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G + +L+E +A PN K G T LH + ++ LD +KLLL P+ N
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--G 602
Query: 525 YTPLDYALLGERHEVIQFMLEHGALSIA-AIQDIAAFKIQA 564
YTPL A + EV + +L++G + A ++Q + + A
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
+ L+EN N NV G TPL A G+ N +
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
Query: 530 YALLGERHEVIQFMLEHGA 548
A +++ +L+ GA
Sbjct: 245 IASRRGNVIMVRLLLDRGA 263
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 199 bits (507), Expect = 7e-51
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
Query: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
Query: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
Query: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
Query: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
Query: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
L A + V + +LE A AA
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 184 bits (466), Expect = 4e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
Query: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
Query: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
Query: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
K + +S +PC +P T + S + SK+
Sbjct: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
Score = 182 bits (461), Expect = 2e-45
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 53/581 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
Query: 198 VHTVRCILDAAP------------------------TESLLNW------QDYEGRTPLHF 227
V VR +LD +E LL+ + G +P+H
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 228 AVADGNVTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
A ++ V +L Y++ + + D+L TPLH AA GH ++ +LL++ G P+
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK---GAKPNS 366
Query: 287 S--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
G TPLH A + N +++ LK + D G T A+ G +++ +L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-- 424
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKD 404
+ N+++ T LH AA +GH K LL+N A+V+A TPL A +GH +
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 464
+++ L++ A +L GH+ LH AA G+ + L+E + + G TPL AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 465 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 524
G + +L+E +A PN K G T LH + ++ LD +KLLL P+ N
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--G 602
Query: 525 YTPLDYALLGERHEVIQFMLEHGALSIA-AIQDIAAFKIQA 564
YTPL A + EV + +L++G + A ++Q + + A
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
+ L+EN N NV G TPL A G+ N +
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
Query: 530 YALLGERHEVIQFMLEHGA 548
A +++ +L+ GA
Sbjct: 245 IASRRGNVIMVRLLLDRGA 263
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 196 bits (498), Expect = 8e-50
Identities = 155/560 (27%), Positives = 266/560 (47%), Gaps = 36/560 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA + L+VGN A + + + G+TPL L R + ++++GA ++
Sbjct: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D + T LH+AA+ G+ + L+T A+ ++ + M PLHL C LL
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-- 393
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
+ ++DT D +T LH +A N E + LL+ ++ D G+ PLH+AA A
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA------A 447
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHF-AVADGNVTVVDVLTSYESCNITSYDNLFR 256
+C+ + + +N D G TPLH+ A +D + ++ L ++ N D
Sbjct: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-NPGIRDKQGY 506
Query: 257 TPLHWAALLGHAQIVHLLLER-------NKSGT-IPSDSQG---ATPLHYAAQSNFAETV 305
+H++A GH + L+ SGT + SDS +PLH AA + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
Query: 306 KVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY--GGTALHA 363
+V ++ D + GRT AA KG + + +++ + I + Y T +HA
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI---LVKDYILKRTPIHA 623
Query: 364 AALSGHVSTVKLLLENNAQVDATDVMK---HTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
AA +GH ++LL+ N +A D+ TPL + GH D + +L+ GA VD D
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-- 478
+ G + LH A+ G+ + L+++ ++D GRTP+ +A G+I + L+++
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 479 --NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536
+A+P D G TALHW+C NG+ ++LLL+ F N ++PL A++ +
Sbjct: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN---AFSPLHCAVINDN 800
Query: 537 HEVIQFMLEHGALSIAAIQD 556
+ +++ SI D
Sbjct: 801 EGAAEMLIDTLGASIVNATD 820
Score = 194 bits (492), Expect = 4e-49
Identities = 146/554 (26%), Positives = 261/554 (47%), Gaps = 54/554 (9%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA G + + LI + A K G PL L+ DC LL +G D++
Sbjct: 343 LHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D RT LH AA GN + LLL A++ +KD +PLH + + +CL L+
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461
Query: 138 APGEVDTQDKNKQTALHWSAYYNNP-EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPS 196
A V+ D+ T LH++A + + ++ L+++D+N GI D +G +H++A +
Sbjct: 462 A--SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519
Query: 197 AVHTVRC------ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
+ + +++ + T+ L + + +PLH A G+ ++VL ++
Sbjct: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ-SLLDLDV 578
Query: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310
++ RTPL AA GH + V +L+ + S + TP+H AA + +E +++ +
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638
Query: 311 HPSVKDDSDLE---GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
+ ++ D++ G+T M + G D + ++L+ +++D DK+G TALH A++
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK--DKWGRTALHRGAVT 696
Query: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL----VDQDG 423
GH V LL++ A+ D TP+ + GH V+ L++ A +D D G
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 424 HSLLHWAALGGNADVCQILIE---------NKINP------------------------- 449
++ LHWA G+ ++L+E N +P
Sbjct: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816
Query: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
N D GRTPL AA+ ++ C+ +L+ +NA N D G+T L + NG + +++L+
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
Query: 510 DFAAFPNQMENNEE 523
A+ +++N +
Sbjct: 877 SSASAELTLQDNSK 890
Score = 191 bits (485), Expect = 3e-48
Identities = 142/485 (29%), Positives = 223/485 (45%), Gaps = 45/485 (9%)
Query: 97 MKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWS 156
++ L+ ++ + +D E+ TPLH + + LL+ ++ V+ +D T LH +
Sbjct: 24 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI--LSGARVNAKDSKWLTPLHRA 81
Query: 157 AYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNW 216
+ E V++L+KH +++ D + PLH AA +K V+C P S +N
Sbjct: 82 VASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANK------AVKCAEALVPLLSNVNV 135
Query: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276
D GRT LH A G+ +V +L S NI ++D R +HWAA +GH ++V LL+
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLS-RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
Query: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDD 336
T D + TPLH AA S VK L ++ + G T A G D
Sbjct: 195 HGAEVTC-KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253
Query: 337 VLRTMLSLKSDI--------------------------------DINMADKYGGTALHAA 364
V+ ++ + + D+NM K G T LH
Sbjct: 254 VVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313
Query: 365 ALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGH 424
AL G S + ++++ A +D D +TPL A GH+ +I TLI GA G
Sbjct: 314 ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGM 373
Query: 425 SLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 484
LH AAL G +D C+ L+ + + + D GRT L AA GG + C+ +L+ AD N
Sbjct: 374 FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK 433
Query: 485 QDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH-EVIQFM 543
+DK GR+ LH++ N + L+ A N ++ E TPL YA + + ++++
Sbjct: 434 KDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD--ERGCTPLHYAATSDTDGKCLEYL 491
Query: 544 LEHGA 548
L + A
Sbjct: 492 LRNDA 496
Score = 191 bits (485), Expect = 3e-48
Identities = 177/595 (29%), Positives = 262/595 (44%), Gaps = 69/595 (11%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA++G ++L+ + D D FGRT L L+C + LL GAD NK
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDI-DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLT-TRHRSPKCLALLLKF 136
D R+ LH AA NY+ + L+ A+ D TPLH T KCL LL+
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRN 494
Query: 137 MA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK------------ 183
A PG +DK A+H+SA Y + ++L+ + + G
Sbjct: 495 DANPG---IRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 184 IPLHWAANHKDPSAVHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242
PLH AA H A+ V+ +LD L+ ++ GRTPL A G+V VDVL +
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLD-------LDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
Query: 243 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER------------------------- 277
+ + L RTP+H AA GH++ + LL+
Sbjct: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
Query: 278 ---------NKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327
NK + + D G T LH A + E V L+H + D GRT
Sbjct: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
Query: 328 WAAGKGSDDVLRTMLSLKSDIDIN--MADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385
+A G VL +L + +D N AD +G TALH A +GH + V+LLLE
Sbjct: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQK 783
Query: 386 TDVMKHTPLFRACEMGHKDVIQTLIK--GGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
T+ +PL A ++ + LI G + V+ D G + LH AA + + Q+L+
Sbjct: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
Query: 444 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-NADPNIQDKEGRTALHWSCNNGYL 502
+ N D G+TPL AA G N + +L+ + +A+ +QD TALH +C+ G+
Sbjct: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHE 903
Query: 503 DAIKLLLDFAAFPNQME-NNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556
+ L+L+ N + N TPL A V+Q +L GA S+ A+ +
Sbjct: 904 TSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA-SVLAVDE 957
Score = 190 bits (483), Expect = 4e-48
Identities = 157/554 (28%), Positives = 248/554 (44%), Gaps = 23/554 (4%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
K E++ F + + +HAAA GD ++ LI+ + + K+ ++ TPL V + +
Sbjct: 30 KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW-LTPLHRAVASCSEE 88
Query: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT 122
LLK ADVN D + +T LH+AA + + L+ +N D T LH
Sbjct: 89 AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148
Query: 123 RHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG 182
+ + LLL A ++ DK + A+HW+AY + E VKLL+ H + + D +
Sbjct: 149 FSGHGEMVKLLLSRGA--NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 183 KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242
PLH AA+ + V+ +LD +N + G TPLH A +G VV+ L
Sbjct: 207 YTPLHAAAS---SGMISVVKYLLDLGVD---MNEPNAYGNTPLHVACYNGQDVVVNELID 260
Query: 243 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA 302
+ + F TPLH+AA H + LL N + G TPLH A
Sbjct: 261 CGAIVNQKNEKGF-TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRF 319
Query: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362
+ ++ +V D D G T AA G + ++ T+++ S D +G LH
Sbjct: 320 SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT--SGADTAKRGIHGMFPLH 377
Query: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422
AALSG + LL + +D D T L A G+ + + L+ GA + D+
Sbjct: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437
Query: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI-NCMAVLMENNAD 481
G S LH+AA N L+ + + N D G TPL AA C+ L+ N+A+
Sbjct: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497
Query: 482 PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME----------NNEERYTPLDYA 531
P I+DK+G A+H+S G+ ++L+ ME +N +PL A
Sbjct: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLA 557
Query: 532 LLGERHEVIQFMLE 545
H+ ++ +++
Sbjct: 558 AYHGHHQALEVLVQ 571
Score = 156 bits (394), Expect = 9e-38
Identities = 153/582 (26%), Positives = 250/582 (42%), Gaps = 100/582 (17%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+HAAA G+ L L++ A +K+D+FGR+PL Y C AL+ +GA VN
Sbjct: 409 LHAAAAGGNLECLN-LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467
Query: 78 DHSQRTALHLAAQKG-NYRFMKLLLTRRANWMQKDLE----------------------- 113
D T LH AA + + ++ LL AN +D +
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527
Query: 114 ----------------------EMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
++PLHL H + L +L++ + ++D ++ + +T
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL--DLDVRNSSGRT 585
Query: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPD-VEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
L +A+ + E V +LI ++I + D + + P+H AA + + R ++ A
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL---RLLIGNAEP 642
Query: 211 ESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQI 270
++ ++ QD G+TPL +V +G+ V L + + N+ + D RT LH A+ GH +
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN-KGANVDAKDKWGRTALHRGAVTGHEEC 701
Query: 271 VHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD----DSDLEGRTSF 326
V LL+ + DS+G TP+H +A + L+ + D +D G T+
Sbjct: 702 VDALLQHGAKCLL-RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
Query: 327 MWAAGKGSDDVLRTML---------------------------------SLKSDIDINMA 353
WA G + + +L +L + I +N
Sbjct: 761 HWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI-VNAT 819
Query: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLI-KG 412
D G T LHAAA + HV ++LLL +NAQV++ D TPL A E G + ++ L+
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879
Query: 413 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP----NVQDYAGRTPLQCAAYGGY 468
A + L D ++ LH A G+ + +LI KI N + A +TPL AA G
Sbjct: 880 SAELTLQDNSKNTALHLACSKGH-ETSALLILEKITDRNLINATNAALQTPLHVAARNGL 938
Query: 469 INCMAVLMENNADPNIQDKEGRT-ALHWSCNNGYLDAIKLLL 509
+ L+ A D+ G T AL + N D + L+L
Sbjct: 939 TMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 92.4 bits (228), Expect = 2e-18
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 2/189 (1%)
Query: 360 ALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV 419
+L A +G V+ L+ V+ D K TPL A +G ++I+ LI GARV+
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENN 479
D + LH A + + Q+L+++ + N +D +TPL AA + C L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV 539
++ N+ D+ GRTALH + +G+ + +KLLL A N + + R + +A EV
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHWAAYMGHIEV 188
Query: 540 IQFMLEHGA 548
++ ++ HGA
Sbjct: 189 VKLLVSHGA 197
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 193 bits (491), Expect = 5e-49
Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA +G ++ L+ + L + G +PL D ++C LL+ A V+
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
TALH+AA G+YR KLLL +RAN + L TPLH+ + K + LL+K+
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A + T+ + T +H +A+ + V LL+++ ++ + ++ G+ LH AA
Sbjct: 401 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 455
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
V VRC+L +L++ + E +TPLH A G +V +L + + + N + T
Sbjct: 456 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 511
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH +A G + +LLE + ++ + +G TPLH AA+ + K+ L+ + D
Sbjct: 512 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
+ G T AA + V +L L+ + K G T LH AA + LL
Sbjct: 571 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Query: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
A+ + TPL A + GH D++ L+ GA + + + G + LH AA +
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 688
Query: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
V IL ++ + + G TPL A + G + + L++ A+ N + K G T LH +
Sbjct: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
Query: 498 NNGYLDAIKLLLDFAAFPNQMENN 521
G+ I +LL A PN N
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTAN 772
Score = 179 bits (453), Expect = 1e-44
Identities = 158/571 (27%), Positives = 250/571 (43%), Gaps = 78/571 (13%)
Query: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
+Q G L + LL G+ V+ TALH+A+ G +K+L+
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
Query: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG------------------------ 140
AN + TPL++ + + LL+ A
Sbjct: 100 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 141 ---EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD--------VEGKIPLHWA 189
E DT+ K + ALH +A ++ + LL+++D N + G PLH A
Sbjct: 160 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 219
Query: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNI 248
A++ + V+ +L+ + +++ G TPLH A GN +V +L +
Sbjct: 220 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308
+ D L TPLH AA GH Q+V LLLER + + G +PLH AAQ + E VK
Sbjct: 274 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 330
Query: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349
L+H + DD L+ T+ AA G V + +L +++ +
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
+ + KYG T +H AA GH++ V LLL+N A D T++ T L A
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
Query: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
G +V++ L++ GA VD ++ + LH A+ G ++ Q+L+++ +P+ G
Sbjct: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
Query: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
TPL +A G ++ +VL+E A ++ K+G T LH + G LD KLLL A +
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
Query: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
N TPL A + +V +LE GA
Sbjct: 571 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 599
Score = 177 bits (450), Expect = 3e-44
Identities = 156/556 (28%), Positives = 259/556 (46%), Gaps = 44/556 (7%)
Query: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
A LD LK G D+N + + ALHLAA++G+ ++ LL R ++ + T
Sbjct: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 79
Query: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177
LH+ + + + +L+K A ++ Q +N T L+ +A N+ + VK L+++ +N
Sbjct: 80 LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 137
Query: 178 P--------------------------DVEGKI---PLHWAANHKDPSAVHTVRCILDAA 208
D +GK+ LH AA D + + A
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197
Query: 209 PTES--LLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALL 265
+S ++N G TPLH A GNV V +L + + + T+ + + TPLH A+
Sbjct: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKR 255
Query: 266 GHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
G+ +V LLL+R G I + ++ G TPLH AA+S + V++ L+ + G +
Sbjct: 256 GNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 313
Query: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384
AA + ++ +L K+ +D D TALH AA GH KLLL+ A +
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPN 371
Query: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
A + TPL AC+ V++ L+K GA + + + G + +H AA G+ ++ +L++
Sbjct: 372 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
Query: 445 NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504
N +P+V + G T L AA G + + L+ N A + + +E +T LH + G +
Sbjct: 432 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 491
Query: 505 IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQ 563
++LLL A P+ N YTPL + + +V +LE GA S+A + +
Sbjct: 492 VQLLLQHMAHPDAATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549
Query: 564 AVYKGYKVRKAFRDRK 579
A Y V K R+
Sbjct: 550 AKYGSLDVAKLLLQRR 565
Score = 167 bits (423), Expect = 4e-41
Identities = 155/598 (25%), Positives = 258/598 (43%), Gaps = 79/598 (13%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA G G +Q L+ G + D + G T L LA + + L+K GA++N
Sbjct: 47 LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ T L++AAQ+ + +K LL AN + TPL + + + +A+LL+
Sbjct: 106 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 165
Query: 138 APGEV---------------------------DTQDK--------NKQTALHWSAYYNNP 162
G+V D Q K + T LH +A+Y N
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225
Query: 163 EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222
LL+ + + G PLH A+ + + V+ +LD ++ + +G
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGN---TNMVKLLLDRG---GQIDAKTRDGL 279
Query: 223 TPLHFAVADGNVTVVDVLT-------------------SYESCNITSYDNLFR------- 256
TPLH A G+ VV++L + + ++ +L +
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 339
Query: 257 ------TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310
T LH AA GH ++ LLL++ + + G TPLH A + N + +++ +K
Sbjct: 340 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVK 398
Query: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370
+ + G T AA G +++ +L L++ ++ + G TALH AA +G V
Sbjct: 399 YGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQV 456
Query: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
V+ LL N A VDA + TPL A +G +++Q L++ A D +G++ LH +
Sbjct: 457 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 516
Query: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
A G DV +L+E ++ G TPL AA G ++ +L++ A + K G
Sbjct: 517 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
Query: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
T LH + + LLL+ A P+ N YTPL A + ++ +L +GA
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 632
Score = 108 bits (270), Expect = 2e-23
Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H A+ G K + +L++ + A D G TPL ++D A LL+AGA +
Sbjct: 480 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 538
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA+ G+ KLLL RRA +TPLH+ + + K LLL+
Sbjct: 539 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195
A KN T LH +A N + L+ + + I +G PLH A+ H D
Sbjct: 599 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 655
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V +LD ++ G T LH A + V V D+LT + + ++ L
Sbjct: 656 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 707
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPL A G+ ++V+ LL++ + + + G TPLH AAQ + V L+H +
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
+ + G T+ A G V+ T+ + ++
Sbjct: 767 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 799
Score = 92.8 bits (229), Expect = 1e-18
Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+ SF+ AA G+ D + + LK IDIN ++ G ALH AA GHV V+ LL
Sbjct: 9 DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
+ VD+ +T L A G +V++ L+K GA ++ Q+G + L+ AA + DV +
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
L+EN N + G TPL A G+ +A+L+EN+ + K ALH +
Sbjct: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 182
Query: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+ LLL D + E +TPL A V +L GA
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 236
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/232 (22%), Positives = 87/232 (37%), Gaps = 32/232 (13%)
Query: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLK 69
AG + + +H AA + D + L++ A + G TPL +++ A LL
Sbjct: 571 AGKNGLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
Query: 70 AGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKC 129
GA+ N T LHLA+Q+G+ + LLL + AN +T LHL +
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689
Query: 130 LALLLKFMAPGE-------------------------------VDTQDKNKQTALHWSAY 158
+L K A + V+ + KN T LH +A
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 749
Query: 159 YNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
+ + +L++H + G L A S V T++ + + T
Sbjct: 750 QGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/139 (27%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
L D ++ AA GN D ++ I+ N + G L AA G++ + L+
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537
+ + K+G TALH + G + +K+L+ A N N +TPL A
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN--GFTPLYMAAQENHI 122
Query: 538 EVIQFMLEHGALSIAAIQD 556
+V++++LE+GA A +D
Sbjct: 123 DVVKYLLENGANQSTATED 141
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 193 bits (491), Expect = 5e-49
Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA +G ++ L+ + L + G +PL D ++C LL+ A V+
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
TALH+AA G+YR KLLL +RAN + L TPLH+ + K + LL+K+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A + T+ + T +H +A+ + V LL+++ ++ + ++ G+ LH AA
Sbjct: 422 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 476
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
V VRC+L +L++ + E +TPLH A G +V +L + + + N + T
Sbjct: 477 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 532
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH +A G + +LLE + ++ + +G TPLH AA+ + K+ L+ + D
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
+ G T AA + V +L L+ + K G T LH AA + LL
Sbjct: 592 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
A+ + TPL A + GH D++ L+ GA + + + G + LH AA +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
V IL ++ + + G TPL A + G + + L++ A+ N + K G T LH +
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 498 NNGYLDAIKLLLDFAAFPNQMENN 521
G+ I +LL A PN N
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTAN 793
Score = 179 bits (453), Expect = 1e-44
Identities = 158/571 (27%), Positives = 250/571 (43%), Gaps = 78/571 (13%)
Query: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
+Q G L + LL G+ V+ TALH+A+ G +K+L+
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG------------------------ 140
AN + TPL++ + + LL+ A
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 141 ---EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD--------VEGKIPLHWA 189
E DT+ K + ALH +A ++ + LL+++D N + G PLH A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNI 248
A++ + V+ +L+ + +++ G TPLH A GN +V +L +
Sbjct: 241 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308
+ D L TPLH AA GH Q+V LLLER + + G +PLH AAQ + E VK
Sbjct: 295 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349
L+H + DD L+ T+ AA G V + +L +++ +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
+ + KYG T +H AA GH++ V LLL+N A D T++ T L A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
G +V++ L++ GA VD ++ + LH A+ G ++ Q+L+++ +P+ G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
TPL +A G ++ +VL+E A ++ K+G T LH + G LD KLLL A +
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
N TPL A + +V +LE GA
Sbjct: 592 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 177 bits (450), Expect = 3e-44
Identities = 156/556 (28%), Positives = 259/556 (46%), Gaps = 44/556 (7%)
Query: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
A LD LK G D+N + + ALHLAA++G+ ++ LL R ++ + T
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177
LH+ + + + +L+K A ++ Q +N T L+ +A N+ + VK L+++ +N
Sbjct: 101 LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 178 P--------------------------DVEGKI---PLHWAANHKDPSAVHTVRCILDAA 208
D +GK+ LH AA D + + A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 209 PTES--LLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALL 265
+S ++N G TPLH A GNV V +L + + + T+ + + TPLH A+
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKR 276
Query: 266 GHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
G+ +V LLL+R G I + ++ G TPLH AA+S + V++ L+ + G +
Sbjct: 277 GNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384
AA + ++ +L K+ +D D TALH AA GH KLLL+ A +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
A + TPL AC+ V++ L+K GA + + + G + +H AA G+ ++ +L++
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 445 NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504
N +P+V + G T L AA G + + L+ N A + + +E +T LH + G +
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 505 IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQ 563
++LLL A P+ N YTPL + + +V +LE GA S+A + +
Sbjct: 513 VQLLLQHMAHPDAATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 564 AVYKGYKVRKAFRDRK 579
A Y V K R+
Sbjct: 571 AKYGSLDVAKLLLQRR 586
Score = 167 bits (423), Expect = 4e-41
Identities = 155/598 (25%), Positives = 258/598 (43%), Gaps = 79/598 (13%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA G G +Q L+ G + D + G T L LA + + L+K GA++N
Sbjct: 68 LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ T L++AAQ+ + +K LL AN + TPL + + + +A+LL+
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 138 APGEV---------------------------DTQDK--------NKQTALHWSAYYNNP 162
G+V D Q K + T LH +A+Y N
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 163 EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222
LL+ + + G PLH A+ + + V+ +LD ++ + +G
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGN---TNMVKLLLDRG---GQIDAKTRDGL 300
Query: 223 TPLHFAVADGNVTVVDVLT-------------------SYESCNITSYDNLFR------- 256
TPLH A G+ VV++L + + ++ +L +
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360
Query: 257 ------TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310
T LH AA GH ++ LLL++ + + G TPLH A + N + +++ +K
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVK 419
Query: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370
+ + G T AA G +++ +L L++ ++ + G TALH AA +G V
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
V+ LL N A VDA + TPL A +G +++Q L++ A D +G++ LH +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
A G DV +L+E ++ G TPL AA G ++ +L++ A + K G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
T LH + + LLL+ A P+ N YTPL A + ++ +L +GA
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 108 bits (270), Expect = 2e-23
Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H A+ G K + +L++ + A D G TPL ++D A LL+AGA +
Sbjct: 501 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA+ G+ KLLL RRA +TPLH+ + + K LLL+
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195
A KN T LH +A N + L+ + + I +G PLH A+ H D
Sbjct: 620 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 676
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V +LD ++ G T LH A + V V D+LT + + ++ L
Sbjct: 677 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 728
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPL A G+ ++V+ LL++ + + + G TPLH AAQ + V L+H +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
+ + G T+ A G V+ T+ + ++
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
Score = 92.8 bits (229), Expect = 1e-18
Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+ SF+ AA G+ D + + LK IDIN ++ G ALH AA GHV V+ LL
Sbjct: 30 DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
+ VD+ +T L A G +V++ L+K GA ++ Q+G + L+ AA + DV +
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
L+EN N + G TPL A G+ +A+L+EN+ + K ALH +
Sbjct: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 203
Query: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+ LLL D + E +TPL A V +L GA
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/232 (22%), Positives = 87/232 (37%), Gaps = 32/232 (13%)
Query: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLK 69
AG + + +H AA + D + L++ A + G TPL +++ A LL
Sbjct: 592 AGKNGLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 70 AGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKC 129
GA+ N T LHLA+Q+G+ + LLL + AN +T LHL +
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 130 LALLLKFMAPGE-------------------------------VDTQDKNKQTALHWSAY 158
+L K A + V+ + KN T LH +A
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Query: 159 YNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
+ + +L++H + G L A S V T++ + + T
Sbjct: 771 QGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
AA GN D ++ I+ N + G L AA G++ + L+ + + K+G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549
TALH + G + +K+L+ A N N +TPL A +V++++LE+GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNG--FTPLYMAAQENHIDVVKYLLENGAN 155
Query: 550 SIAAIQD 556
A +D
Sbjct: 156 QSTATED 162
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 193 bits (491), Expect = 5e-49
Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA +G ++ L+ + L + G +PL D ++C LL+ A V+
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
TALH+AA G+YR KLLL +RAN + L TPLH+ + K + LL+K+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
A + T+ + T +H +A+ + V LL+++ ++ + ++ G+ LH AA
Sbjct: 422 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 476
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
V VRC+L +L++ + E +TPLH A G +V +L + + + N + T
Sbjct: 477 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 532
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH +A G + +LLE + ++ + +G TPLH AA+ + K+ L+ + D
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
+ G T AA + V +L L+ + K G T LH AA + LL
Sbjct: 592 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
A+ + TPL A + GH D++ L+ GA + + + G + LH AA +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497
V IL ++ + + G TPL A + G + + L++ A+ N + K G T LH +
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 498 NNGYLDAIKLLLDFAAFPNQMENN 521
G+ I +LL A PN N
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTAN 793
Score = 179 bits (453), Expect = 1e-44
Identities = 158/571 (27%), Positives = 250/571 (43%), Gaps = 78/571 (13%)
Query: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
+Q G L + LL G+ V+ TALH+A+ G +K+L+
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG------------------------ 140
AN + TPL++ + + LL+ A
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 141 ---EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD--------VEGKIPLHWA 189
E DT+ K + ALH +A ++ + LL+++D N + G PLH A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNI 248
A++ + V+ +L+ + +++ G TPLH A GN +V +L +
Sbjct: 241 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308
+ D L TPLH AA GH Q+V LLLER + + G +PLH AAQ + E VK
Sbjct: 295 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349
L+H + DD L+ T+ AA G V + +L +++ +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
+ + KYG T +H AA GH++ V LLL+N A D T++ T L A
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Query: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
G +V++ L++ GA VD ++ + LH A+ G ++ Q+L+++ +P+ G
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Query: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
TPL +A G ++ +VL+E A ++ K+G T LH + G LD KLLL A +
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
N TPL A + +V +LE GA
Sbjct: 592 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 177 bits (450), Expect = 3e-44
Identities = 156/556 (28%), Positives = 259/556 (46%), Gaps = 44/556 (7%)
Query: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
A LD LK G D+N + + ALHLAA++G+ ++ LL R ++ + T
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177
LH+ + + + +L+K A ++ Q +N T L+ +A N+ + VK L+++ +N
Sbjct: 101 LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 178 P--------------------------DVEGKI---PLHWAANHKDPSAVHTVRCILDAA 208
D +GK+ LH AA D + + A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 209 PTES--LLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALL 265
+S ++N G TPLH A GNV V +L + + + T+ + + TPLH A+
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKR 276
Query: 266 GHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
G+ +V LLL+R G I + ++ G TPLH AA+S + V++ L+ + G +
Sbjct: 277 GNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384
AA + ++ +L K+ +D D TALH AA GH KLLL+ A +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
A + TPL AC+ V++ L+K GA + + + G + +H AA G+ ++ +L++
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 445 NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504
N +P+V + G T L AA G + + L+ N A + + +E +T LH + G +
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 505 IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQ 563
++LLL A P+ N YTPL + + +V +LE GA S+A + +
Sbjct: 513 VQLLLQHMAHPDAATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 564 AVYKGYKVRKAFRDRK 579
A Y V K R+
Sbjct: 571 AKYGSLDVAKLLLQRR 586
Score = 167 bits (423), Expect = 4e-41
Identities = 155/598 (25%), Positives = 258/598 (43%), Gaps = 79/598 (13%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA G G +Q L+ G + D + G T L LA + + L+K GA++N
Sbjct: 68 LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ T L++AAQ+ + +K LL AN + TPL + + + +A+LL+
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 138 APGEV---------------------------DTQDK--------NKQTALHWSAYYNNP 162
G+V D Q K + T LH +A+Y N
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 163 EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222
LL+ + + G PLH A+ + + V+ +LD ++ + +G
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGN---TNMVKLLLDRG---GQIDAKTRDGL 300
Query: 223 TPLHFAVADGNVTVVDVLT-------------------SYESCNITSYDNLFR------- 256
TPLH A G+ VV++L + + ++ +L +
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360
Query: 257 ------TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310
T LH AA GH ++ LLL++ + + G TPLH A + N + +++ +K
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVK 419
Query: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370
+ + G T AA G +++ +L L++ ++ + G TALH AA +G V
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
V+ LL N A VDA + TPL A +G +++Q L++ A D +G++ LH +
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
A G DV +L+E ++ G TPL AA G ++ +L++ A + K G
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
T LH + + LLL+ A P+ N YTPL A + ++ +L +GA
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 108 bits (270), Expect = 2e-23
Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H A+ G K + +L++ + A D G TPL ++D A LL+AGA +
Sbjct: 501 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
T LH+AA+ G+ KLLL RRA +TPLH+ + + K LLL+
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195
A KN T LH +A N + L+ + + I +G PLH A+ H D
Sbjct: 620 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 676
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V +LD ++ G T LH A + V V D+LT + + ++ L
Sbjct: 677 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 728
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
TPL A G+ ++V+ LL++ + + + G TPLH AAQ + V L+H +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
+ + G T+ A G V+ T+ + ++
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
Score = 92.8 bits (229), Expect = 1e-18
Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+ SF+ AA G+ D + + LK IDIN ++ G ALH AA GHV V+ LL
Sbjct: 30 DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
+ VD+ +T L A G +V++ L+K GA ++ Q+G + L+ AA + DV +
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
L+EN N + G TPL A G+ +A+L+EN+ + K ALH +
Sbjct: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 203
Query: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+ LLL D + E +TPL A V +L GA
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/232 (22%), Positives = 87/232 (37%), Gaps = 32/232 (13%)
Query: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLK 69
AG + + +H AA + D + L++ A + G TPL +++ A LL
Sbjct: 592 AGKNGLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 70 AGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKC 129
GA+ N T LHLA+Q+G+ + LLL + AN +T LHL +
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 130 LALLLKFMAPGE-------------------------------VDTQDKNKQTALHWSAY 158
+L K A + V+ + KN T LH +A
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Query: 159 YNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210
+ + +L++H + G L A S V T++ + + T
Sbjct: 771 QGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
AA GN D ++ I+ N + G L AA G++ + L+ + + K+G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549
TALH + G + +K+L+ A N N +TPL A +V++++LE+GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNG--FTPLYMAAQENHIDVVKYLLENGAN 155
Query: 550 SIAAIQD 556
A +D
Sbjct: 156 QSTATED 162
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 193 bits (490), Expect = 7e-49
Identities = 159/570 (27%), Positives = 257/570 (45%), Gaps = 48/570 (8%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H A+ G + L+ A D + G T L LA + + L+ GA+VN
Sbjct: 78 LHLASKEGHVEVVSELLQ-REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ T L++AAQ+ + +K LL A+ + TPL + + + ++LLL
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL--- 193
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
E DT+ K + ALH +A ++ + LL+++D+N + G PLH AA++ +
Sbjct: 194 ---ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN--- 247
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
++ +L+ A D TPLH A GN +V +L I + T
Sbjct: 248 INVATLLLNRAAAVDFTARNDI---TPLHVASKRGNANMVKLLLD-RGAKIDAKTRDGLT 303
Query: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317
PLH A GH Q+V +LL+R + + G +PLH A Q + V++ L+H DD
Sbjct: 304 PLHCGARSGHEQVVEMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
Query: 318 SDLEGRTSFMWAAGKGSDDVLRTMLS-------------------------------LKS 346
+ T+ AA G V + +L LK
Sbjct: 363 VTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Query: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVI 406
I + G T +H AA GHV+ V L+ + A + T+V T L A G +V+
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Query: 407 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYG 466
+ L++ GA+V+ +D + LH +A G AD+ Q L++ +PN +G TPL +A
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSARE 542
Query: 467 GYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
G+ + A L+++ A +I K+G T LH + G L+ LLL +A P+ + T
Sbjct: 543 GHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA--GKSGLT 600
Query: 527 PLDYALLGERHEVIQFMLEHGALSIAAIQD 556
PL A + +V +L+ GA AA ++
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKN 630
Score = 190 bits (482), Expect = 6e-48
Identities = 151/519 (29%), Positives = 235/519 (45%), Gaps = 36/519 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H A +G + ++ L+ + + K G +PL D L+C LL+ V+
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKN-GLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
+ TALH+AA G+Y+ K+LL ++AN K L TPLH+ + K + LLLK
Sbjct: 364 TNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG 423
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH----- 192
A + T+ + T +H +A+ + V L+ H ++ +V G+ LH AA
Sbjct: 424 ASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
Query: 193 ----------------KDPSAVHTVRCILDAAPTESLL------NWQDYEGRTPLHFAVA 230
D + +H + A + LL N G TPLH +
Sbjct: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541
Query: 231 DGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG 289
+G+ V L + S +IT+ TPLH AA G ++ +LLL+++ S S G
Sbjct: 542 EGHEDVAAFLLDHGASLSITTKKGF--TPLHVAAKYGKLEVANLLLQKSASPDAAGKS-G 598
Query: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
TPLH AA + + + L + + G T AA K D+ T+L +D
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA- 657
Query: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409
N + G ++H AA GHV V LLL NA V+ ++ TPL A + +V + L
Sbjct: 658 -NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Query: 410 IKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI 469
+ GA VD + G++ LH GN + L+++ N + G TPL AA G+
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
Query: 470 NCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
+ + VL++NNA PN G TAL + GY+ + L
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 171 bits (433), Expect = 3e-42
Identities = 160/569 (28%), Positives = 254/569 (44%), Gaps = 54/569 (9%)
Query: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117
A L+ A +K G D+N + + ALHLA+++G+ + LL R AN + T
Sbjct: 51 AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTA 110
Query: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------- 170
LH+ + + + +L+ A V+ Q +N T L+ +A N+ E VK L+
Sbjct: 111 LHIASLAGQAEVVKVLVTNGA--NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
Query: 171 ----------------HDSNIGI---PDVEGKI---PLHWAANHKDPSAVHTVRCILDAA 208
HD + + D +GK+ LH AA D A + + A
Sbjct: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 209 PTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC-NITSYDNLFRTPLHWAALLGH 267
ES G TPLH A GN+ V +L + + + T+ +++ TPLH A+ G+
Sbjct: 229 DVES------KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI--TPLHVASKRGN 280
Query: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327
A +V LLL+R + G TPLH A+S + V++ L + G +
Sbjct: 281 ANMVKLLLDRG-AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339
Query: 328 WAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATD 387
A D + L L+ ++ ++ TALH AA GH K+LL+ A +A
Sbjct: 340 MAT--QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
Query: 388 VMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKI 447
+ TPL AC+ V++ L+K GA + V + G + +H AA G+ ++ L+ +
Sbjct: 398 LNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 448 NPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKL 507
+PN + G T L AA G + L+++ A + K+ +T LH S G D ++
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 508 LLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA-LSIAAIQDIAAFKIQAVY 566
LL A PN + YTPL + +V F+L+HGA LSI + + A Y
Sbjct: 518 LLQQGASPNAATTS--GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 567 KGYKVRKAFRDRKNLLMKHEQLRKDAAAK 595
+V NLL++ + DAA K
Sbjct: 576 GKLEV-------ANLLLQ-KSASPDAAGK 596
Score = 92.4 bits (228), Expect = 2e-18
Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 33/265 (12%)
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+ S++ AA G + + + +K+ +DIN+ ++ G ALH A+ GHV V LL+
Sbjct: 40 DANASYLRAARAGHLE--KALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
A VDA +T L A G +V++ L+ GA V+ Q+G + L+ AA + +V +
Sbjct: 98 ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA-------------------- 480
L++N + ++ G TPL A G+ +++L+EN+
Sbjct: 158 FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKA 217
Query: 481 ---------DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
+ +++ K G T LH + + G ++ LLL+ AA + N+ TPL A
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND--ITPLHVA 275
Query: 532 LLGERHEVIQFMLEHGALSIAAIQD 556
+++ +L+ GA A +D
Sbjct: 276 SKRGNANMVKLLLDRGAKIDAKTRD 300
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 154 bits (388), Expect = 5e-37
Identities = 113/331 (34%), Positives = 164/331 (49%), Gaps = 7/331 (2%)
Query: 219 YEGR-TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
YE + TPLHF VA G+V V +L ++E ++ TPL AA + LLL
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 278 NKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
D G PLH+AAQ+ T ++ L H + D + EG T AA ++V
Sbjct: 418 GADAN-RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476
Query: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397
R ++S ++D +++ A+ G T LH AA GHVS VKLL A++DA TPL A
Sbjct: 477 ARLLVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
Query: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457
E G IQ L+K GA D +DQ G+ LH AA G +C++L+ + + + G
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
TPL AAY G++ + +L E++A+ T LH + +G + LL A PN
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
E + +TPL A+ + +LEH A
Sbjct: 655 AE--QSGWTPLHLAVQRSTFLSVINLLEHHA 683
Score = 130 bits (327), Expect = 5e-30
Identities = 110/383 (28%), Positives = 174/383 (45%), Gaps = 17/383 (4%)
Query: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
RL++ + D + G TPL+ + D LL GAD N+ D LH AAQ
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
Query: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
G+ +LLL A ++ E TPLHL ++ LL+ A + + + +T
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA--DPNLHEAEGKT 496
Query: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
LH +AY+ + VKLL + + + PLH A + V ++ +L +
Sbjct: 497 PLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV---ERGKVRAIQHLLKSGAVP 553
Query: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQI 270
L D G PLH A A G + +L Y S + ++ TPLH AA GH +I
Sbjct: 554 DAL---DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW--TPLHLAAYKGHLEI 608
Query: 271 VHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWA 329
+HLL E + + G + + TPLH AA+ V L+ + + ++ G T A
Sbjct: 609 IHLLAESHANMGAL--GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Query: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
+ + L + L+ +++ +K G T H AAL G+ + +K+L+E AQ+D D +
Sbjct: 667 VQRST--FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV 724
Query: 390 KHTPLFRACEMGHKDVIQTLIKG 412
TPL A K I + ++G
Sbjct: 725 SCTPLQLALR-SRKQGIMSFLEG 746
Score = 128 bits (321), Expect = 3e-29
Identities = 129/488 (26%), Positives = 208/488 (42%), Gaps = 48/488 (9%)
Query: 57 LADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMT 116
LA ++ C +L + G +VN+ D SQ + + GNY L L+ R N + +D EE+
Sbjct: 304 LARKVSCKLSLRQPG-EVNE-DISQEL---MDSDSGNYLKRALQLSDRKNLVPRD-EEL- 356
Query: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
C+ +NK T LH+ + E V+LL+ H+ ++
Sbjct: 357 ------------CIY---------------ENKVTPLHFLVAQGSVEQVRLLLAHEVDVD 389
Query: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
G PL AA + P C L A N D +G PLHFA +G+
Sbjct: 390 CQTASGYTPLLIAAQDQQPDL-----CALLLAHGADA-NRVDEDGWAPLHFAAQNGDDGT 443
Query: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYA 296
+L + +C + + + TPLH AA + LL+ R + +++G TPLH A
Sbjct: 444 ARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL-HEAEGKTPLHVA 501
Query: 297 AQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY 356
A VK+ + D RT A +G ++ +L KS + D+
Sbjct: 502 AYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL--KSGAVPDALDQS 559
Query: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
G LH AA G K+LL A ++ TPL A GH ++I L + A +
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
Query: 417 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 476
+ + LH AA G V L++ +PN + +G TPL A + L+
Sbjct: 620 GALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679
Query: 477 ENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME-NNEERYTPLDYALLGE 535
E++A+ + ++K G T H + G +K+L++ A Q++ + TPL AL
Sbjct: 680 EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA---QLDVQDGVSCTPLQLALRSR 736
Query: 536 RHEVIQFM 543
+ ++ F+
Sbjct: 737 KQGIMSFL 744
Score = 117 bits (292), Expect = 6e-26
Identities = 114/376 (30%), Positives = 165/376 (43%), Gaps = 14/376 (3%)
Query: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
TPL + V ++ LL DV+ S T L +AAQ LLL A+ +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169
D + PLH ++ LLL A VD Q++ T LH +A N +LL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGAC--VDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 170 KHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAV 229
++ + + EGK PLH AA S V +L + E L+ Q RTPLH AV
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVK----LLTSQGAE--LDAQQRNLRTPLHLAV 535
Query: 230 ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG 289
G V + L + D PLH AA G I +LL S +P+ QG
Sbjct: 536 ERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT-HQG 593
Query: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
TPLH AA E + + + + T AA G + V+ + L+ D
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL--LQCGAD 651
Query: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409
N A++ G T LH A +V LLE++A V A + + TP A G+ +++ L
Sbjct: 652 PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
Query: 410 IKGGARVDLVDQDGHS 425
++ GA++D+ QDG S
Sbjct: 712 VEAGAQLDV--QDGVS 725
Score = 79.3 bits (194), Expect = 1e-14
Identities = 84/301 (27%), Positives = 127/301 (42%), Gaps = 51/301 (16%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
+H AA G +L +L+ A D + + RTPL V ++ LLK+GA +
Sbjct: 498 LHVAAYFGHV-SLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL 556
Query: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
D S LH AA +G Y K+LL A+ + TPLHL
Sbjct: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL----------------- 599
Query: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
+AY + E + LL + +N+G PLH AA H + +
Sbjct: 600 ------------------AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
Query: 198 VHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGN-VTVVDVLTSYESCNITSYDNLF 255
V ++C D N + G TPLH AV ++V+++L + N+ + + +
Sbjct: 642 VSALLQCGADP-------NAAEQSGWTPLHLAVQRSTFLSVINLLEHH--ANVHARNKVG 692
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL--KHPS 313
TP H AAL G+ I+ +L+E + D TPL A +S + + FL K PS
Sbjct: 693 WTPAHLAALKGNTAILKVLVEAGAQLDV-QDGVSCTPLQLALRSR-KQGIMSFLEGKEPS 750
Query: 314 V 314
V
Sbjct: 751 V 751
Score = 70.9 bits (172), Expect = 5e-12
Identities = 65/232 (28%), Positives = 104/232 (44%), Gaps = 9/232 (3%)
Query: 13 SLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72
+L + +H A G A+Q L+ + A+ D DQ G PL + LL+ GA
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
+ H T LHLAA KG+ + LL AN TPLHL RH ++
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
LL+ A + + +++ T LH + + V L++H +N+ + G P H AA
Sbjct: 645 LLQCGA--DPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA-L 701
Query: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244
K +A+ ++ +++A + L+ QD TPL A+ ++ L E
Sbjct: 702 KGNTAI--LKVLVEAG---AQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 149 bits (377), Expect = 9e-36
Identities = 180/650 (27%), Positives = 260/650 (40%), Gaps = 106/650 (16%)
Query: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
S + G ++ AA +G++ L L+ + D TPL +R+
Sbjct: 325 SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI 384
Query: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTT 122
LL+ GADV+ D LH A G+Y +LLL A DL + TPLH +
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444
Query: 123 RHRSPKCLALLLKFMAPGEVDTQDKNK-----QTALHWSAYYNNPEHVKL-------LIK 170
++R C LL P V+ K+ L Y H L L K
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 504
Query: 171 HDSNIGIPDVEGKIPL-HWAANHKDPSAVHTVRCILDAAPTESLL------NWQDYEGRT 223
+ + + K P H A H +++H R TE LL N ++ + T
Sbjct: 505 VKKTLALEIINFKQPQSHETALHCAVASLHPKR----KQVTELLLRKGANVNEKNKDFMT 560
Query: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283
PLH A + V++VL + + + D L +T LH AAL GH Q LLL +I
Sbjct: 561 PLHVAAERAHNDVMEVLHKH-GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343
S QG T AAQ E V+ L + SD++ R + A K D L T+
Sbjct: 620 IS-LQGFT----AAQMG-NEAVQQILSESTPIRTSDVDYR---LLEASKAGD--LETVKQ 668
Query: 344 LKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401
L S ++N D G T LH AA VS V+ LL + A V A D PL AC G
Sbjct: 669 LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
Query: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP------------ 449
H +V + L++ GA V++ D + LH AA G ++C++L+++ +P
Sbjct: 729 HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
Query: 450 ----------------------------------------NVQDYAGR--TPLQCAAYGG 467
N +D GR TPL AA
Sbjct: 789 LVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYN 848
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ L+E+ AD N QDK G LH + + G++D LL+ + N ++ +TP
Sbjct: 849 NLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN--ATDKWAFTP 906
Query: 528 LDYALLGERHEVIQFMLEHGA------------LSIAAIQDIAAFKIQAV 565
L A R ++ +L HGA L +A DI A I A+
Sbjct: 907 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM 956
Score = 124 bits (312), Expect = 3e-28
Identities = 145/563 (25%), Positives = 238/563 (42%), Gaps = 56/563 (9%)
Query: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADAL 67
A S ++ A NGD ++RL+ ++A + +D GR +PL + R D + L
Sbjct: 178 AVSGALRELLEACRNGDVSRVKRLV--DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235
Query: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRS 126
L+ GA+V+ D LH A G+ + LLL + A+ +D TPLH + +
Sbjct: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295
Query: 127 PKCLALLLKFMAPGEVDTQDKN------------------KQTALHWSAYYNNPEHVKLL 168
C+ LL P +T K+ K L + N + + LL
Sbjct: 296 DVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL 355
Query: 169 IKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFA 228
+ N D PLH AA + + V V+ +L ++ +D G PLH A
Sbjct: 356 TPLNVNCHASDGRKSTPLHLAAGY---NRVRIVQLLLQHGAD---VHAKDKGGLVPLHNA 409
Query: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
+ G+ V ++L + +C + + D TPLH AA ++ LLL T+ +
Sbjct: 410 CSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN--- 465
Query: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
H + + A T P +++ E + + A + + D+ + +L +I
Sbjct: 466 ----CHGKSAVDMAPT-------PELRERLTYEFKGHSLLQAAREA-DLAKVKKTLALEI 513
Query: 349 DINMADKYGGTALHAAALSGH---VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
+ TALH A S H +LLL A V+ + TPL A E H DV
Sbjct: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
Query: 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 465
++ L K GA+++ +D G + LH AAL G+ C++L+ +P++ G T AA
Sbjct: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQ 629
Query: 466 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERY 525
G +L E+ I+ + L + G L+ +K L + N +
Sbjct: 630 MGNEAVQQILSESTP---IRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHS 685
Query: 526 TPLDYALLGERHEVIQFMLEHGA 548
TPL +A R V++++L HGA
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGA 708
Score = 107 bits (268), Expect = 4e-23
Identities = 118/422 (27%), Positives = 189/422 (44%), Gaps = 63/422 (14%)
Query: 176 GIPDVEGKI-PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR--TPLHFAVADG 232
G+P V G + L A + D V V+ ++DAA +N +D GR +PLHFA G
Sbjct: 175 GVPAVSGALRELLEACRNGD---VSRVKRLVDAAN----VNAKDMAGRKSSPLHFAAGFG 227
Query: 233 NVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGA 290
VV+ L N+ + D+ PLH A GHA++V LLL + G P+ D+
Sbjct: 228 RKDVVEHLLQM-GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ---GADPNARDNWNY 283
Query: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSF--------------------MWAA 330
TPLH AA + V L+H + + + +G+++ + AA
Sbjct: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAA 343
Query: 331 GKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMK 390
G+++ L +L+ +++ + +D T LH AA V V+LLL++ A V A D
Sbjct: 344 RSGNEEKLMALLT-PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 391 HTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
PL AC GH +V + L+K GA V+ +D + LH AA +VC +L+ + +P
Sbjct: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462
Query: 451 VQDYAGRTPLQCA-----------AYGGYINCMAVLMENNADPN----------IQDKEG 489
+ + G++ + A + G+ A + A Q +
Sbjct: 463 LVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH 522
Query: 490 RTALHW---SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH 546
TALH S + +LLL A N E N++ TPL A ++V++ + +H
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGA--NVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580
Query: 547 GA 548
GA
Sbjct: 581 GA 582
Score = 50.8 bits (120), Expect = 5e-06
Identities = 39/110 (35%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
+D+ G PL +D A L+K VN TD T LH AAQKG + LLL
Sbjct: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Query: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTAL 153
A+ K+ E TPL L T + ALL+ M P + T K + T +
Sbjct: 926 GADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVV 972
>gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
Length = 614
Score = 148 bits (374), Expect = 2e-35
Identities = 98/294 (33%), Positives = 142/294 (48%), Gaps = 8/294 (2%)
Query: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75
+ V+ AA NGD AL +I + ++ + D G TPLM+ V + D LLK GA++N
Sbjct: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
Query: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
D RT+L LA G LL A D PLH T + L +LL+
Sbjct: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
E++ QD T LHW+A++N P+H ++L+K ++ + D + K LHWA
Sbjct: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV----- 203
Query: 196 SAVHTVRC--ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
+ + + C IL S++N+ D G+T +H A A G ++ L CN+ + D
Sbjct: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDV 263
Query: 254 LFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKV 307
RTPLHWAA G A+ V LLE + D +TPL YA VK+
Sbjct: 264 DDRTPLHWAAAAGKAECVQSLLELGMDSNL-RDINESTPLAYALYCGHTACVKL 316
Score = 108 bits (269), Expect = 3e-23
Identities = 88/283 (31%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
T ++ AA G + ++ + S DS+G TPL +A A+TVK+ LK + +
Sbjct: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
D GRTS A G + ++L ++ N+ DK G LHAA + + +L
Sbjct: 89 MQDAYGRTSLCLATYLGWLEGCVSLL--RNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
Query: 377 LE--NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
L+ N ++++ D TPL A Q L+K GA LVD+D + LHWA G
Sbjct: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
Query: 435 NADVCQILIENKINP---NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ--DKEG 489
N +C I++ + P N D +G+T + AA G+ + + L + N+Q D +
Sbjct: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL-ARVPECNLQALDVDD 265
Query: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
RT LHW+ G + ++ LL+ N + NE TPL YAL
Sbjct: 266 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINES--TPLAYAL 306
Score = 98.6 bits (244), Expect = 2e-20
Identities = 85/278 (30%), Positives = 121/278 (43%), Gaps = 11/278 (3%)
Query: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIV 271
S+L D EG TPL AV+ V +L NI D RT L A LG +
Sbjct: 52 SILECCDSEGCTPLMHAVSGRQADTVKLLLKM-GANINMQDAYGRTSLCLATYLGWLEGC 110
Query: 272 HLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD--DSDLEGRTSFMWA 329
LL IP D G PLH A + V L+ ++ + D EG T WA
Sbjct: 111 VSLLRNGAKHNIP-DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWA 169
Query: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN---AQVDAT 386
A T + LK D + DK TALH A SG+ ++L ++ + ++
Sbjct: 170 AFHNQPQ--HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYD 227
Query: 387 DVMKHTPLFRACEMGHKDVIQTLIK-GGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
D T + A G D+I L + + +D D + LHWAA G A+ Q L+E
Sbjct: 228 DESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLEL 287
Query: 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVL-MENNADP 482
++ N++D TPL A Y G+ C+ +L E+ +P
Sbjct: 288 GMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEP 325
Score = 84.7 bits (208), Expect = 3e-16
Identities = 71/269 (26%), Positives = 121/269 (44%), Gaps = 9/269 (3%)
Query: 285 SDSQGATPLHYAAQSNFAETVKVFLKH-PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343
S+ T ++ AA + + ++ PS+ + D EG T M A D ++ L
Sbjct: 23 SEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVK--LL 80
Query: 344 LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHK 403
LK +INM D YG T+L A G + LL N A+ + D PL A
Sbjct: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
Query: 404 DVIQTLIKGG--ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461
++ L++ + ++ D +G + LHWAA Q+L++ +P + D +T L
Sbjct: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
Query: 462 CAAYGGYINCMAVLMENNADPNI---QDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQM 518
A G ++++ ++ P+I D+ G+T +H + G+ D I L Q
Sbjct: 201 WAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQA 260
Query: 519 ENNEERYTPLDYALLGERHEVIQFMLEHG 547
+ ++R TPL +A + E +Q +LE G
Sbjct: 261 LDVDDR-TPLHWAAAAGKAECVQSLLELG 288
Score = 81.3 bits (199), Expect = 4e-15
Identities = 61/218 (27%), Positives = 100/218 (45%), Gaps = 6/218 (2%)
Query: 312 PSVKD----DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
PSV D DS E + ++ A D T + + + D G T L A
Sbjct: 12 PSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSG 71
Query: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
TVKLLL+ A ++ D T L A +G + +L++ GA+ ++ D++G L
Sbjct: 72 RQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPL 131
Query: 428 HWAALGGNADVCQILIE--NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
H A + + +L++ N N QD G TPL AA+ +L++ ADP +
Sbjct: 132 HAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLV 191
Query: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE 523
DK+ +TALHW+ +G ++L P+ + ++E
Sbjct: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDE 229
Score = 70.1 bits (170), Expect = 9e-12
Identities = 50/189 (26%), Positives = 87/189 (46%), Gaps = 1/189 (0%)
Query: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARV-DLVDQDGHSLLHWAALGGNADVCQIL 442
D+++ + T +++A G + + +I+ + + D +G + L A G AD ++L
Sbjct: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
Query: 443 IENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYL 502
++ N N+QD GRT L A Y G++ L+ N A NI DK GR LH + +
Sbjct: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
Query: 503 DAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI 562
+ +LL + + E TPL +A + + Q +L+ GA +D
Sbjct: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
Query: 563 QAVYKGYKV 571
AV G ++
Sbjct: 201 WAVQSGNRI 209
Score = 38.1 bits (87), Expect = 0.037
Identities = 26/83 (31%), Positives = 36/83 (43%)
Query: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
VH AA G + L D RTPL + A + +C +LL+ G D N
Sbjct: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
Query: 78 DHSQRTALHLAAQKGNYRFMKLL 100
D ++ T L A G+ +KLL
Sbjct: 295 DINESTPLAYALYCGHTACVKLL 317
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 142 bits (359), Expect = 1e-33
Identities = 161/620 (25%), Positives = 251/620 (40%), Gaps = 92/620 (14%)
Query: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
S + G ++ +A +G++ + L+ + D TPL +R+
Sbjct: 167 SAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKI 226
Query: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
LL+ GADV+ D LH A G+Y +LL+ A DL + TPLH
Sbjct: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
Query: 124 HRSPKCLALLLKFMA-PGEVDTQDKNK-----QTALHWSAYYNNPEHVKLLIKHDSNI-- 175
+ +LLL + A P ++ +K+ L Y H L ++++
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 176 -----GIPDVEGKIP------LHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTP 224
+ V K P LH AA P +L +N + E TP
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN---INEKTKEFLTP 403
Query: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284
LH A + VV+V+ +E+ + + DNL +T LH AA GH Q LLL I
Sbjct: 404 LHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII 462
Query: 285 SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
S QG T L E V+ L+ +S+ + + + AA G + ++ + ++
Sbjct: 463 S-LQGFTALQMGN-----ENVQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTV 514
Query: 345 KSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGH 402
+S +N D G T LH AA VS V+ LL++ A V A D PL AC GH
Sbjct: 515 QS---VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH 571
Query: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP------------- 449
+V + L+K GA V++ D + LH AA G ++C++L+++ +P
Sbjct: 572 YEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
Query: 450 ---------------------------------------NVQDYAGR--TPLQCAAYGGY 468
N +D GR TPL AA
Sbjct: 632 VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNN 691
Query: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPL 528
+ L+++ AD N QDK G LH + + G++D LL+ + A N ++ +TPL
Sbjct: 692 LEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN--ATDKWAFTPL 749
Query: 529 DYALLGERHEVIQFMLEHGA 548
A R ++ +L HGA
Sbjct: 750 HEAAQKGRTQLCALLLAHGA 769
Score = 134 bits (338), Expect = 3e-31
Identities = 128/454 (28%), Positives = 203/454 (44%), Gaps = 53/454 (11%)
Query: 76 KTDHSQRTALHLAAQKG---NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
K + TALH AA + +LLL + AN +K E +TPLH+ + + +
Sbjct: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
Query: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
++K A +V+ D QT+LH +AY + + +LL+ + + I ++G L +
Sbjct: 419 VVKHEA--KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN 476
Query: 193 KDPSAVHTV--------RCILDAAP-----------TESLLNWQDYEGR--TPLHFAVAD 231
+ R +L+AA T +N +D EGR TPLHFA
Sbjct: 477 VQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536
Query: 232 GNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGAT 291
V+VV+ L + ++ + D PLH A GH ++ LL++ + +D T
Sbjct: 537 NRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFT 594
Query: 292 PLHYAAQSNFAETVKVFLKHPS---------------VKD-DSDLE----GRTSFMWAAG 331
PLH AA E K+ L+H + VKD D+D++ G + + AA
Sbjct: 595 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAK 654
Query: 332 KGSDDVLRTMLSLKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
KG L + L S ++N D G T LH AA ++ + LL++ A V+A D
Sbjct: 655 KGC---LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449
PL A GH DV LIK A V+ D+ + LH AA G +C +L+ + +P
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Query: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483
+++ G+TPL + + M +A P+
Sbjct: 772 TLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805
Score = 133 bits (334), Expect = 8e-31
Identities = 153/613 (24%), Positives = 253/613 (41%), Gaps = 100/613 (16%)
Query: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADALLKAGA 72
A ++ A NGD ++RL+ + D GR TPL + R D + LL+ GA
Sbjct: 25 ARELFEACRNGDVERVKRLVTPEKV--NSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRSPKCLA 131
+V D LH A G+ + LLL A+ +D TPLH + + C+
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
Query: 132 LL-------------------------------------------------LKFMAPGEV 142
LL + + P V
Sbjct: 143 LLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNV 202
Query: 143 D--TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
+ D K T LH +A YN + V+LL++H +++ D +PLH A ++ T
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEV--T 260
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE------SCNITSYDNL 254
+ A ++ WQ TPLH A + V V +L SY +C+ S +L
Sbjct: 261 ELLVKHGACVNAMDLWQ----FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDL 316
Query: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTI--------------PSDSQGATPLHYAAQSN 300
TP L + H LL+ + + T LH AA S
Sbjct: 317 APTP-QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASP 375
Query: 301 F---AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYG 357
+ + ++ L+ + ++ E T A+ K +DV+ + +K + +N D G
Sbjct: 376 YPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVV--VKHEAKVNALDNLG 433
Query: 358 GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD 417
T+LH AA GH+ T +LLL + + F A +MG+++V Q L +G +
Sbjct: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG----FTALQMGNENVQQLLQEG---IS 486
Query: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR--TPLQCAAYGGYINCMAVL 475
L + + L AA G+ + + L + + N +D GR TPL AA ++ + L
Sbjct: 487 LGNSEADRQLLEAAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYL 545
Query: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535
+++ AD + +DK G LH +C+ G+ + +LL+ A N + ++TPL A
Sbjct: 546 LQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD--LWKFTPLHEAAAKG 603
Query: 536 RHEVIQFMLEHGA 548
++E+ + +L+HGA
Sbjct: 604 KYEICKLLLQHGA 616
Score = 110 bits (276), Expect = 4e-24
Identities = 114/410 (27%), Positives = 181/410 (44%), Gaps = 59/410 (14%)
Query: 210 TESLLNWQDYEGR--TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGH 267
T +N +D GR TPLHFA G VV+ L N+ + D+ PLH A GH
Sbjct: 45 TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ-NGANVQARDDGGLIPLHNACSFGH 103
Query: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327
A++V+LLL R+ + D+ TPLH AA + V L+H + + +GRT+
Sbjct: 104 AEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALD 162
Query: 328 WAAGKGS---------DDVLRT--------MLSLKSDIDINM--ADKYGGTALHAAALSG 368
A D++L + M++L + +++N +D T LH AA
Sbjct: 163 LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYN 222
Query: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428
V V+LLL++ A V A D PL AC GH +V + L+K GA V+ +D + LH
Sbjct: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 429 WAALGGNADVCQILIENKINPNV----------------------QDYAGRTPLQCAAYG 466
AA +VC +L+ +P + ++ G + LQ A
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 467 GYINC---MAVLMENNADPNIQDKEGRTALHWSCNNGY---LDAIKLLLDFAAFPNQMEN 520
+++ M N P + TALH + + Y +LLL A N E
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHE----TALHCAAASPYPKRKQICELLLRKGA--NINEK 396
Query: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI-QAVYKGY 569
+E TPL A ++V++ +++H A + A+ ++ + +A Y G+
Sbjct: 397 TKEFLTPLHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGH 445
Score = 58.2 bits (139), Expect = 3e-08
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 6/137 (4%)
Query: 414 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR--TPLQCAAYGGYINC 471
A + V+ L G V +++ K+N +D AGR TPL AA G +
Sbjct: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNS--RDTAGRKSTPLHFAAGFGRKDV 73
Query: 472 MAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
+ L++N A+ +D G LH +C+ G+ + + LLL A PN +N YTPL A
Sbjct: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDN--WNYTPLHEA 131
Query: 532 LLGERHEVIQFMLEHGA 548
+ + +V +L+HGA
Sbjct: 132 AIKGKIDVCIVLLQHGA 148
Score = 47.0 bits (110), Expect = 8e-05
Identities = 36/96 (37%), Positives = 45/96 (46%), Gaps = 3/96 (3%)
Query: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
+D+ G PL +D A L+K A VN TD T LH AAQKG + LLL
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Query: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
A+ K+ E TPL L + + ALL M P
Sbjct: 768 GADPTLKNQEGQTPLDLVS---ADDVSALLTAAMPP 800
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 139 bits (351), Expect = 9e-33
Identities = 99/329 (30%), Positives = 166/329 (50%), Gaps = 8/329 (2%)
Query: 221 GRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNK 279
G+TPL A GN+ +V +++ + +CN+ DN T L A+ GH IV LL+
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW--TALISASKEGHVHIVEELLKCGV 95
Query: 280 SGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339
+ D G T L +A + V++ L H + + L +WAAG+G D++
Sbjct: 96 N-LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 154
Query: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399
L L++ +N +DKYG T L AA GH+ VK LL A VD T L A +
Sbjct: 155 --LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVK 212
Query: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459
G+ ++ ++K V+L D+DG++ L A+ G+ ++ Q L++ N+ D +G T
Sbjct: 213 GGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTV 272
Query: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519
L A GG++ + L++ AD +I+ ++ +TAL+W+ G ++ +L P+
Sbjct: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ--CNPDTEI 330
Query: 520 NNEERYTPLDYALLGERHEVIQFMLEHGA 548
++ TPL A EV++ +L+ GA
Sbjct: 331 CTKDGETPLIKATKMRNIEVVELLLDKGA 359
Score = 139 bits (350), Expect = 1e-32
Identities = 113/370 (30%), Positives = 180/370 (48%), Gaps = 12/370 (3%)
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
+VD +++ QT L +A N E VK LIK+ +N + D++ L A+ VH
Sbjct: 30 DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE---GHVHI 86
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259
V +L L +D G T L +A G VV++L S+ + ++T +++ P+
Sbjct: 87 VEELLKCGVN---LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY--PI 141
Query: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
WAA GHA IVHLLL+ N + SD G TPL +AA+ E VK L + D
Sbjct: 142 IWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
T+ + A G ++ +L K + ++N+ DK G TAL A+ GH V+ LL+
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
Query: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
V+ D T L A GH ++++ L++ A +D+ QD + L+WA GNA +
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
Query: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
+ +++ + + G TPL A I + +L++ A + DK+G T LH +
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378
Query: 500 GYLDAIKLLL 509
+LLL
Sbjct: 379 RSRKLAELLL 388
Score = 132 bits (331), Expect = 2e-30
Identities = 109/404 (26%), Positives = 188/404 (46%), Gaps = 15/404 (3%)
Query: 59 DRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL 118
+ + ALL+ DV++ + +T L +AA++GN +K L+ AN +DL+ T L
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 119 HLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIP 178
++ + LLK ++ +D TAL W+ Y + V+LL+ H +N +
Sbjct: 76 ISASKEGHVHIVEELLK--CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 179 DVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238
+ P+ WAA VH + + +N D G TPL +A G++ V
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLL------LQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
Query: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
L + ++ T L A G+ Q V +L+RN + + +D G T L A++
Sbjct: 188 HLLAM-GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASK 245
Query: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358
E V+ L + + D G T + A G +++R +L +DIDI D
Sbjct: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD--NK 303
Query: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL 418
TAL+ A G+ + V+ +L+ N + TPL +A +M + +V++ L+ GA+V
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
Query: 419 VDQDGHSLLHWAALGGNADVCQILIENKINPNV---QDYAGRTP 459
VD+ G + LH A G + + ++L+ N + + + AG TP
Sbjct: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
Score = 96.3 bits (238), Expect = 1e-19
Identities = 54/169 (31%), Positives = 89/169 (52%)
Query: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
D++ ++ G T L AA G++ VK L++N A + D+ T L A + GH +++
Sbjct: 30 DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
Query: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
L+K G ++ D G + L WA G DV ++L+ + NP+V P+ AA G+
Sbjct: 90 LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
Query: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
+ + +L++N A N DK G T L W+ G+L+ +K LL A +Q
Sbjct: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198
Score = 88.2 bits (217), Expect = 3e-17
Identities = 99/392 (25%), Positives = 157/392 (40%), Gaps = 48/392 (12%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
AA G+ ++ LI N A + ED T L+ + + LLK G ++ D
Sbjct: 45 AAEQGNLEIVKELIK-NGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMG 103
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
TAL A KG ++LLL+ AN L + P
Sbjct: 104 GWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP----------------------- 140
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
+ W+A + + V LL+++ + + D G PL WAA
Sbjct: 141 ------------IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH------ 182
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADG-NVTVVDVLTSYESCNITSYDNLFRTPL 259
+ C+ + ++ + T L AV G +V ++L + N+T D T L
Sbjct: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG--NTAL 240
Query: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
A+ GH +IV LL+ IP D G T L A + E V+ L+ + D
Sbjct: 241 MIASKEGHTEIVQDLLDAGTYVNIP-DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
Query: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
+ +T+ WA KG+ ++R +L D +I K G T L A ++ V+LLL+
Sbjct: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEI--CTKDGETPLIKATKMRNIEVVELLLDK 357
Query: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
A+V A D TPL A + + + L++
Sbjct: 358 GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/294 (26%), Positives = 134/294 (45%), Gaps = 13/294 (4%)
Query: 33 LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92
L++ N A + D++G TPL++ L+C LL GADV++ + TAL +A + G
Sbjct: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214
Query: 93 NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTA 152
+ +K +L R N D + T L + ++ + + LL A V+ D++ T
Sbjct: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD--AGTYVNIPDRSGDTV 272
Query: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTES 212
L + + E V+ L++ ++I I + K L+WA + + VR IL P
Sbjct: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT---MVRDILQCNPDTE 329
Query: 213 LLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVH 272
+ +G TPL A N+ VV++L + +++ D TPLH A ++
Sbjct: 330 ICT---KDGETPLIKATKMRNIEVVELLLD-KGAKVSAVDKKGDTPLHIAIRGRSRKLAE 385
Query: 273 LLLERNKSGTI--PSDSQGATPLHYAAQSNFAETVKVF-LKHPS-VKDDSDLEG 322
LLL K G + + G TP + + ++F +H S + D D+ G
Sbjct: 386 LLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLG 439
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 136 bits (343), Expect = 8e-32
Identities = 109/380 (28%), Positives = 166/380 (43%), Gaps = 45/380 (11%)
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
DV+ S + LHLA + G K LL AN + TPLH+ R + L
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
LL V+ +D+++ TALH++A + +LL++ ++++
Sbjct: 490 LLARKI--SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV----------------- 530
Query: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYD 252
N D+EGRTP+H A G +V +L +++
Sbjct: 531 ----------------------NEVDFEGRTPMHVACQHGQENIVRILLR-RGVDVSLQG 567
Query: 253 NLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
PLH+AA GH IV LL ++ G TPLH AAQ ++ +
Sbjct: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627
Query: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372
S + L +T AA G R +L + + +D Y TALH AA +GH++T
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY--TALHLAARNGHLAT 685
Query: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAAL 432
VKLL+E A V A + T L A GH +V++ L+ +DL D+ G S LH AA
Sbjct: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ 744
Query: 433 GGNADVCQILIENKINPNVQ 452
G +A + L+ + + N+Q
Sbjct: 745 GRHAQTVETLLRHGAHINLQ 764
Score = 125 bits (314), Expect = 2e-28
Identities = 106/364 (29%), Positives = 174/364 (47%), Gaps = 14/364 (3%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
A V+GD L +++ D G + L V A + +CA LL A+ N ++
Sbjct: 413 AIVSGDTSKLMKILQPQDV--DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRR 470
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
T LH+A ++ ++LLL R+ + KD ++ T LH ++ LLL+ A
Sbjct: 471 GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA-- 528
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
V+ D +T +H + + V++L++ ++ + + +PLH+AA V
Sbjct: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK- 587
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLH 260
+L P S +N Q +GRTPLH A G+ V +L S ++ L +TPLH
Sbjct: 588 ---LLAKQPGVS-VNAQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLH 642
Query: 261 WAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDL 320
AA GH LLL R +G S G T LH AA++ TVK+ ++ +
Sbjct: 643 VAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGP 701
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
+T+ AA G +V+ ++S +D+ I++ D+ G +ALH AA H TV+ LL +
Sbjct: 702 LNQTALHLAAAHGHSEVVEELVS--ADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Query: 381 AQVD 384
A ++
Sbjct: 759 AHIN 762
Score = 119 bits (298), Expect = 1e-26
Identities = 96/385 (24%), Positives = 164/385 (42%), Gaps = 45/385 (11%)
Query: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
L+K + P +VD + + LH + E K L+ +++N + + G PLH A
Sbjct: 422 LMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVER 481
Query: 193 KDPSAVHTVRCILDAAPTESL-LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
+ VR +++ + +N +D + T LHFA +G+ + +L ++ ++
Sbjct: 482 R-------VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE-KNASVNEV 533
Query: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
D RTP+H A G IV +LL R ++ PLHYAA VK+ K
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDAWLPLHYAAWQGHLPIVKLLAKQ 592
Query: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVS 371
P V +N G T LH AA GH
Sbjct: 593 PGVS----------------------------------VNAQTLDGRTPLHLAAQRGHYR 618
Query: 372 TVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
++L++ + V+ ++ TPL A E GH + L+ GA + + DG++ LH AA
Sbjct: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
Query: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 491
G+ ++L+E K + + +T L AA G+ + L+ + ++ D++G +
Sbjct: 679 RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLS 737
Query: 492 ALHWSCNNGYLDAIKLLLDFAAFPN 516
ALH + + ++ LL A N
Sbjct: 738 ALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 111 bits (278), Expect = 3e-24
Identities = 78/261 (29%), Positives = 128/261 (49%), Gaps = 5/261 (1%)
Query: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
GA+ LH A ++ E K L + + + S+ G T A + V+ +L+ K I
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK--I 495
Query: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
+N D+ TALH AA +G S+ +LLLE NA V+ D TP+ AC+ G +++++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENK-INPNVQDYAGRTPLQCAAYGG 467
L++ G V L +D LH+AA G+ + ++L + ++ N Q GRTPL AA G
Sbjct: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
Query: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
+ +L++ +D N+ +T LH + G+ +LLL A M + YT
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM--TSDGYTA 673
Query: 528 LDYALLGERHEVIQFMLEHGA 548
L A ++ ++E A
Sbjct: 674 LHLAARNGHLATVKLLVEEKA 694
Score = 90.5 bits (223), Expect = 6e-18
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
S D + M L+ D+++A G + LH A +G K LL NNA + ++ TP
Sbjct: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
Query: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
L A E + V++ L+ V+ D+D + LH+AA G+ ++L+E + N D
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAA 513
+ GRTP+ A G N + +L+ D ++Q K+ LH++ G+L +KLL
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 514 FPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
+ + R TPL A + V + +++
Sbjct: 595 VSVNAQTLDGR-TPLHLAAQRGHYRVARILID 625
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 135 bits (339), Expect = 2e-31
Identities = 139/519 (26%), Positives = 230/519 (44%), Gaps = 21/519 (4%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
++E+ AG S + A GD A+++L++ ++ + ++ G + L A +
Sbjct: 223 RAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEE-GESLLCLACSAGYYE 281
Query: 63 CADALLKAGADV-NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLT 121
A LL A+V ++ T L AA G+ + +KLLL +A+ + T L
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 122 TRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE 181
+ +LL+ A ++ ++N T L + + E +LL+++ + I E
Sbjct: 342 CAGGYVDVVKVLLESGA--SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
Query: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
K A +K + VR +L+A + + E T L A DG+V V +L
Sbjct: 400 FKESALTLACYK--GHLEMVRFLLEAGADQE---HKTDEMHTALMEACMDGHVEVARLLL 454
Query: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
+ + F +PL AA GH ++ LL+ER S +D +G TPL AA+
Sbjct: 455 D-SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND-EGYTPLMEAAREGH 512
Query: 302 AETVKVFL-KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
E V + L + ++ ++ T+ A G +V ++ +DI++ + T
Sbjct: 513 EEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TP 567
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
L AA GH+ VK LL A V AT T L ACE GH DV L++ GA ++
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPN-VQDYAGRTPLQCAAYGGYINCMAVLMENN 479
+ G + L AA G+ Q LI N N T L A GG++ + +L+ +
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQM 518
ADP + K+G T L + G+ + LLD +PN +
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD---YPNNL 723
Score = 119 bits (297), Expect = 2e-26
Identities = 97/294 (32%), Positives = 147/294 (50%), Gaps = 10/294 (3%)
Query: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
TPL AA GH +IV LLL +K+ S G T L YA + + VKV L+ + +
Sbjct: 303 TPLMAAANGGHVKIVKLLLA-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
D + G T M A G +V R +L + I+ + ++++ +AL A GH+ V+ L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFL 420
Query: 377 LENNA-QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LE A Q TD M HT L AC GH +V + L+ GA+V++ S L AA GG+
Sbjct: 421 LEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALH 494
++ +LIE + + G TPL AA G+ +A+L+ A+ N Q +E + TAL
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+C G+L+ L+ A + TPL A E+++++L GA
Sbjct: 540 LACCGGFLEVADFLIKAGA-----DIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Score = 103 bits (256), Expect = 9e-22
Identities = 129/504 (25%), Positives = 217/504 (43%), Gaps = 58/504 (11%)
Query: 141 EVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
++D Q + N TAL + + E V+ L++ ++I D +G PL AA V
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT---AGHVG 1130
Query: 200 TVRCILDAAPTESLLNWQDYEGR------TPLHFAVADGNVTVVDVL----TSYESCNIT 249
V +LD N D E + TPL A + G VV++L + E N++
Sbjct: 1131 VVEILLD--------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
Query: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVF 308
Y TPL AA G+ I+ +LL + S+ G +PL AA + VK+
Sbjct: 1183 DY-----TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Query: 309 LKHPS-VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
L S + + T+ A +G +V+ +L K++++ K G T L AA
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA--KTGLTPLMEAASG 1295
Query: 368 GHVSTVKLLLENNAQVDATDV--MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425
G+ ++LL+ A V+A V + T L A + GH + LI GA +D+ ++ G++
Sbjct: 1296 GYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1355
Query: 426 LLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-ENNADPNI 484
L AA GG+ DV Q+L++ + + D TPL A G++ + L+ E N P+
Sbjct: 1356 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS- 1414
Query: 485 QDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFML 544
D E + + L L ++ Q ++ + + ++L E ++ +
Sbjct: 1415 -DSECMRYIATITDKEMLKKCHLCMESIV---QAKDRQAAEANKNASILLEELDLEKLRE 1470
Query: 545 EHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRK 604
E L++AA ++ R K K EQ RK + + +EN
Sbjct: 1471 ESRRLALAA------------------KREKRKEKRRKKKEEQRRKLEEIEAKNKENFEL 1512
Query: 605 EAEQQKGRRSPDSCRPQALPCLPS 628
+A Q+K + + P+ L PS
Sbjct: 1513 QAAQEKEKLKVED-EPEVLTEPPS 1535
Score = 103 bits (256), Expect = 9e-22
Identities = 101/342 (29%), Positives = 150/342 (43%), Gaps = 18/342 (5%)
Query: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
+T+ + TAL LA G+ ++ LL R A+ +D + TPL L + +LL
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
A E + ++ K T L + E V+LL+ +N +V PL AA+
Sbjct: 1138 NGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS---G 1193
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V+ ++ +L+A E G +PL A +G+ V +L S +
Sbjct: 1194 GYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------ 309
T L A G ++V LLL+R K+ G TPL AA +AE +V L
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDR-KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Query: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369
P V D T+ AA KG ++ + ID+ +K G T L AA GH
Sbjct: 1312 NAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVR--NKKGNTPLWLAANGGH 1365
Query: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
+ V+LL++ A VDA D K TPL A GH V++ L+K
Sbjct: 1366 LDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 76.3 bits (186), Expect = 1e-13
Identities = 89/360 (24%), Positives = 146/360 (40%), Gaps = 44/360 (12%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-KTDH 79
A G + +Q L+ ++++ + D+ G TPL+ A + + LL GAD+ +++
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 1148
Query: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
++ T L LA G ++LLL R AN +++ + TPL L + +LL A
Sbjct: 1149 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1208
Query: 140 GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
T K + L +A + VKLL+ S+I + +
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN-------------------AQIE 1249
Query: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259
T R T L A G VV +L N+ TPL
Sbjct: 1250 TNR-------------------NTALTLACFQGRTEVVSLLLD-RKANVEHRAKTGLTPL 1289
Query: 260 HWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDS 318
AA G+A++ +LL++ P S T L AA + ++ + + D
Sbjct: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ +G T AA G DV++ ++ +D+D AD T L AA GHV V+ L++
Sbjct: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVD--AADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 49.7 bits (117), Expect = 1e-05
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 4/142 (2%)
Query: 15 ASQVHAAAVNGDKGALQ--RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72
+S+ A + DKG + L++G A D ++ G TPL LD L++AGA
Sbjct: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL-HLTTRHRSPKCLA 131
DV+ D+ + T L A +KG+ + ++ L+ + N D E M + +T + KC
Sbjct: 1378 DVDAADNRKITPLMAAFRKGHVKVVRYLV-KEVNQFPSDSECMRYIATITDKEMLKKCHL 1436
Query: 132 LLLKFMAPGEVDTQDKNKQTAL 153
+ + + + NK ++
Sbjct: 1437 CMESIVQAKDRQAAEANKNASI 1458
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 135 bits (339), Expect = 2e-31
Identities = 139/519 (26%), Positives = 230/519 (44%), Gaps = 21/519 (4%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
++E+ AG S + A GD A+++L++ ++ + ++ G + L A +
Sbjct: 223 RAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEE-GESLLCLACSAGYYE 281
Query: 63 CADALLKAGADV-NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLT 121
A LL A+V ++ T L AA G+ + +KLLL +A+ + T L
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 122 TRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE 181
+ +LL+ A ++ ++N T L + + E +LL+++ + I E
Sbjct: 342 CAGGYVDVVKVLLESGA--SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
Query: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
K A +K + VR +L+A + + E T L A DG+V V +L
Sbjct: 400 FKESALTLACYK--GHLEMVRFLLEAGADQE---HKTDEMHTALMEACMDGHVEVARLLL 454
Query: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
+ + F +PL AA GH ++ LL+ER S +D +G TPL AA+
Sbjct: 455 D-SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND-EGYTPLMEAAREGH 512
Query: 302 AETVKVFL-KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
E V + L + ++ ++ T+ A G +V ++ +DI++ + T
Sbjct: 513 EEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TP 567
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
L AA GH+ VK LL A V AT T L ACE GH DV L++ GA ++
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPN-VQDYAGRTPLQCAAYGGYINCMAVLMENN 479
+ G + L AA G+ Q LI N N T L A GG++ + +L+ +
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQM 518
ADP + K+G T L + G+ + LLD +PN +
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD---YPNNL 723
Score = 119 bits (297), Expect = 2e-26
Identities = 97/294 (32%), Positives = 147/294 (50%), Gaps = 10/294 (3%)
Query: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
TPL AA GH +IV LLL +K+ S G T L YA + + VKV L+ + +
Sbjct: 303 TPLMAAANGGHVKIVKLLLA-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
D + G T M A G +V R +L + I+ + ++++ +AL A GH+ V+ L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFL 420
Query: 377 LENNA-QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LE A Q TD M HT L AC GH +V + L+ GA+V++ S L AA GG+
Sbjct: 421 LEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALH 494
++ +LIE + + G TPL AA G+ +A+L+ A+ N Q +E + TAL
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+C G+L+ L+ A + TPL A E+++++L GA
Sbjct: 540 LACCGGFLEVADFLIKAGA-----DIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Score = 103 bits (256), Expect = 9e-22
Identities = 129/504 (25%), Positives = 217/504 (43%), Gaps = 58/504 (11%)
Query: 141 EVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
++D Q + N TAL + + E V+ L++ ++I D +G PL AA V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT---AGHVG 879
Query: 200 TVRCILDAAPTESLLNWQDYEGR------TPLHFAVADGNVTVVDVL----TSYESCNIT 249
V +LD N D E + TPL A + G VV++L + E N++
Sbjct: 880 VVEILLD--------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 931
Query: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVF 308
Y TPL AA G+ I+ +LL + S+ G +PL AA + VK+
Sbjct: 932 DY-----TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Query: 309 LKHPS-VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
L S + + T+ A +G +V+ +L K++++ K G T L AA
Sbjct: 987 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA--KTGLTPLMEAASG 1044
Query: 368 GHVSTVKLLLENNAQVDATDV--MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425
G+ ++LL+ A V+A V + T L A + GH + LI GA +D+ ++ G++
Sbjct: 1045 GYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1104
Query: 426 LLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-ENNADPNI 484
L AA GG+ DV Q+L++ + + D TPL A G++ + L+ E N P+
Sbjct: 1105 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS- 1163
Query: 485 QDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFML 544
D E + + L L ++ Q ++ + + ++L E ++ +
Sbjct: 1164 -DSECMRYIATITDKEMLKKCHLCMESIV---QAKDRQAAEANKNASILLEELDLEKLRE 1219
Query: 545 EHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRK 604
E L++AA ++ R K K EQ RK + + +EN
Sbjct: 1220 ESRRLALAA------------------KREKRKEKRRKKKEEQRRKLEEIEAKNKENFEL 1261
Query: 605 EAEQQKGRRSPDSCRPQALPCLPS 628
+A Q+K + + P+ L PS
Sbjct: 1262 QAAQEKEKLKVED-EPEVLTEPPS 1284
Score = 103 bits (256), Expect = 9e-22
Identities = 101/342 (29%), Positives = 150/342 (43%), Gaps = 18/342 (5%)
Query: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
+T+ + TAL LA G+ ++ LL R A+ +D + TPL L + +LL
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
A E + ++ K T L + E V+LL+ +N +V PL AA+
Sbjct: 887 NGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS---G 942
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V+ ++ +L+A E G +PL A +G+ V +L S +
Sbjct: 943 GYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1001
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------ 309
T L A G ++V LLL+R K+ G TPL AA +AE +V L
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDR-KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Query: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369
P V D T+ AA KG ++ + ID+ +K G T L AA GH
Sbjct: 1061 NAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVR--NKKGNTPLWLAANGGH 1114
Query: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
+ V+LL++ A VDA D K TPL A GH V++ L+K
Sbjct: 1115 LDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 76.3 bits (186), Expect = 1e-13
Identities = 89/360 (24%), Positives = 146/360 (40%), Gaps = 44/360 (12%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-KTDH 79
A G + +Q L+ ++++ + D+ G TPL+ A + + LL GAD+ +++
Sbjct: 839 ACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
Query: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
++ T L LA G ++LLL R AN +++ + TPL L + +LL A
Sbjct: 898 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
Query: 140 GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
T K + L +A + VKLL+ S+I + +
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN-------------------AQIE 998
Query: 200 TVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPL 259
T R T L A G VV +L N+ TPL
Sbjct: 999 TNR-------------------NTALTLACFQGRTEVVSLLLD-RKANVEHRAKTGLTPL 1038
Query: 260 HWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDS 318
AA G+A++ +LL++ P S T L AA + ++ + + D
Sbjct: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
Query: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+ +G T AA G DV++ ++ +D+D AD T L AA GHV V+ L++
Sbjct: 1099 NKKGNTPLWLAANGGHLDVVQLLVQAGADVD--AADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 49.7 bits (117), Expect = 1e-05
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 4/142 (2%)
Query: 15 ASQVHAAAVNGDKGALQ--RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72
+S+ A + DKG + L++G A D ++ G TPL LD L++AGA
Sbjct: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL-HLTTRHRSPKCLA 131
DV+ D+ + T L A +KG+ + ++ L+ + N D E M + +T + KC
Sbjct: 1127 DVDAADNRKITPLMAAFRKGHVKVVRYLV-KEVNQFPSDSECMRYIATITDKEMLKKCHL 1185
Query: 132 LLLKFMAPGEVDTQDKNKQTAL 153
+ + + + NK ++
Sbjct: 1186 CMESIVQAKDRQAAEANKNASI 1207
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 131 bits (330), Expect = 2e-30
Identities = 135/512 (26%), Positives = 222/512 (43%), Gaps = 18/512 (3%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
K+EN AG + A +GD A+++L+ ++ + ++ G + L A +
Sbjct: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYE 252
Query: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYR-FMKLLLTRRANWMQKDLEEMTPLHLT 121
A LL A+V + +AA G Y +KLLL A+ + T L
Sbjct: 253 LAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYA 312
Query: 122 TRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE 181
+ +LL A ++ ++N T L +A + E ++L+ H + I E
Sbjct: 313 CAGGFVDIVKVLLNEGA--NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
Query: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
K A +K + VR +L+A + + E T L A DG+V V +L
Sbjct: 371 FKESALTLACYK--GHLDMVRFLLEAGADQE---HKTDEMHTALMEACMDGHVEVARLLL 425
Query: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
+ + F +PL AA GH ++ LL+ER + +D +G TPL AA+
Sbjct: 426 D-SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND-EGYTPLMEAAREGH 483
Query: 302 AETVKVFLKH-PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
E V + L ++ ++ T+ A G +V ++ +DI++ + T
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TP 538
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
L A+ GH+ VK LL + A V AT T L ACE GH DV L++ GA ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPN-VQDYAGRTPLQCAAYGGYINCMAVLMENN 479
+ G + L AA G+ Q LI N N T + A GG++ + +L+ +
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDF 511
ADP + K+G T L + G+ + + LLD+
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 127 bits (320), Expect = 4e-29
Identities = 115/449 (25%), Positives = 196/449 (43%), Gaps = 55/449 (12%)
Query: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGT 282
T L A A G+ +V VL + ++ I D TPL AA GH +V +LL++
Sbjct: 1057 TALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 283 IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML 342
S+ TPL A E V + L + K+ ++ T AA G ++++ +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 343 SLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDAT-DVMKHTPLFRACEMG 401
+ ++I+ K G + L AA++GHV VKLLL+ + ++A + ++T L AC G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV----------------------- 438
+V+ L+ A V+ + G + L AA GG A+V
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 439 ------------CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
C++LI + +V++ G TPL A+ GG+ + + +L++ AD + D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 487 KEGRTALHWSCNNGYLDAIKLLL-DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
T L + G++ ++ L+ + FP+ +E T D LL + H+
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQ------- 1408
Query: 546 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE---EENK 602
++ I K Q + K +L E+ RK A A KRE E+ K
Sbjct: 1409 -------CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRK 1461
Query: 603 RKEAEQQKGRRSPDSCRPQALPCLPSTQD 631
+K+ EQ++ + + +P+ LP +D
Sbjct: 1462 KKKEEQKRKQEEDEENKPKENSELPEDED 1490
Score = 118 bits (295), Expect = 3e-26
Identities = 111/354 (31%), Positives = 169/354 (47%), Gaps = 15/354 (4%)
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFR- 256
V+ VR +LD + +N EG + L A + G + VL + + N+ N
Sbjct: 218 VNAVRKLLDEGRS---VNEHTEEGESLLCLACSAGYYELAQVLLAMHA-NVEDRGNKGDI 273
Query: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
TPL A+ G+ IV LLL + S + G T L YA F + VKV L + +
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQS-ATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
D + G T M AA G +V R +L + I+ + ++++ +AL A GH+ V+ L
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFL 391
Query: 377 LENNA-QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LE A Q TD M HT L AC GH +V + L+ GA+V++ S L AA GG+
Sbjct: 392 LEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALH 494
++ +LIE N + G TPL AA G+ +A+L+ A+ N Q +E + TAL
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
Query: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+C G+ + L+ A + TPL A E+++++L GA
Sbjct: 511 LACCGGFSEVADFLIKAGA-----DIELGCSTPLMEASQEGHLELVKYLLASGA 559
Score = 117 bits (292), Expect = 6e-26
Identities = 139/576 (24%), Positives = 234/576 (40%), Gaps = 51/576 (8%)
Query: 214 LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHL 273
+N Q G T L +A A G V +V VL + E NI ++ TPL AA GH ++ +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 274 LLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKG 333
LL+ S+ + L A + V+ L+ + ++ E T+ M A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
+V R +L S +NM + L AA GHV LL+E A ++ + +TP
Sbjct: 417 HVEVARLLLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 394 LFRACEMGHKDVIQTLIKGGARVDL-VDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 452
L A GH++++ L+ GA ++ ++ + L A GG ++V LI K +++
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI--KAGADIE 532
Query: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
TPL A+ G++ + L+ + A+ + G TAL ++C NG+ D +LL
Sbjct: 533 -LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVR 572
A + +E TPL A +QF++ GA A + + G +
Sbjct: 592 A--DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 573 KAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRS---------PDSCRPQAL 623
LL+ H A R ++ E KG + P++ ++
Sbjct: 650 VV-----ELLLAH-----GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV--LSV 697
Query: 624 PCLPSTQDVPSRQSRAPSKQPPAGNVA-----QGPEPRDSRGSPGGSLGGALQKEQHVSS 678
P +Q P Q ++ + P +A Q P+ SP LG + SS
Sbjct: 698 PTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSP-ALLGVQKGTSKQKSS 756
Query: 679 DLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRELRLQIIQRE-- 736
LQ + + H C+ EG + ++EK++ L++IQ E
Sbjct: 757 SLQVADQ---DLLPSFHPYQPLECI-VEETEGKLNELGQRISAIEKAQLKSLELIQGEPL 812
Query: 737 ---------RRRKELFRKKNKAAAVIQRAWRSYQLR 763
+ R+E +KK K +Q+ R Q++
Sbjct: 813 NKDKIEELKKNREEQVQKKKKILKELQKVERQLQMK 848
Score = 104 bits (260), Expect = 3e-22
Identities = 102/342 (29%), Positives = 150/342 (43%), Gaps = 20/342 (5%)
Query: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKF 136
T+ + TAL LA G+ + +L+ R A +D + TPL L + +LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
Query: 137 MAPGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
G+++ Q ++ K T L + E V LL+ +N +V PL AA+
Sbjct: 1110 -KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS---G 1165
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V+ ++ +L+A E G +PL A +G+V V +L S +
Sbjct: 1166 GYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------ 309
T L A G A++V LLL+R K+ G TPL AA +AE +V L
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDR-KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369
P V D T+ AA KG ++ + ID+ +K G T L A+ GH
Sbjct: 1284 NAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVR--NKKGNTPLWLASNGGH 1337
Query: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
V+LL++ A VDA D K TPL A GH V+Q L+K
Sbjct: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 72.4 bits (176), Expect = 2e-12
Identities = 86/359 (23%), Positives = 140/359 (38%), Gaps = 43/359 (11%)
Query: 22 AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-KTDHS 80
A G L +++ A + D+ G TPL+ A + + LL G D+ +++ +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
+ T L LA G + LLL R AN +++ + TPL L + +LL A
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
T K + L +A + VKLL+ S+I + + T
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN-------------------AQIET 1222
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLH 260
R T L A G VV +L N+ TPL
Sbjct: 1223 NR-------------------NTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLM 1262
Query: 261 WAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
AA G+A++ +LL++ P S T L AA + ++ + + D +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+G T A+ G DV++ ++ +D+D AD T L +A GHV V+ L++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVD--AADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 65.9 bits (159), Expect = 2e-10
Identities = 82/333 (24%), Positives = 138/333 (41%), Gaps = 12/333 (3%)
Query: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75
S + A G ++ L+ + + K D+ T LM + ++ A LL +GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
S + L LAA G+ LL+ R AN + + E TPL R + +ALLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
A T++ ++TAL + E LIK ++I ++ PL A+
Sbjct: 493 QGANINAQTEE-TQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQE--- 545
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
+ V+ +L + ++ G T L +A +G+ V DVL ++
Sbjct: 546 GHLELVKYLLASGAN---VHATTATGDTALTYACENGHTDVADVLLQ-AGADLEHESEGG 601
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
RTPL AA GH V L+ + + + + T + A V++ L H +
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
+G T + AA G +V+ +L +++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 60.8 bits (146), Expect = 5e-09
Identities = 95/414 (22%), Positives = 160/414 (38%), Gaps = 54/414 (13%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
+N+ N+ + + + AA G + L+ + + ++F + L
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
LD LL+AGAD TAL A G+ +LLL A
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA--------------- 429
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
+V+ + ++ L +A + E LLI+ +N+ +
Sbjct: 430 --------------------QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 181 EGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238
EG PL AA H++ A+ + A TE T L A G V D
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEE-------TQETALTLACCGGFSEVAD 522
Query: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
L + + TPL A+ GH ++V LL + + + + G T L YA +
Sbjct: 523 FLIKAGA----DIELGCSTPLMEASQEGHLELVKYLL-ASGANVHATTATGDTALTYACE 577
Query: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358
+ + V L+ + + GRT M AA G ++ ++S ++++ A+
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-DH 636
Query: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMK--HTPLFRACEMGHKDVIQTLI 410
T + A GH++ V+LLL + A D T +K T L A + GH +V+ L+
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGA--DPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 60.1 bits (144), Expect = 9e-09
Identities = 77/310 (24%), Positives = 130/310 (41%), Gaps = 24/310 (7%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
AA G G ++ L+ ++ + ++ TPL R + D LL GA+ + S
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEM--TPLHLTTRHRSPKCLALLLKFMA 138
T L LAA G +K+LL A + ++ +PL L + + LLL
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM-- 1212
Query: 139 PGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
+++ Q + N+ TAL + + E V LL+ +N+ G PL AA+
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAAS---GGY 1269
Query: 198 VHTVRCILD------AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
R +LD A P S + T L A G+ ++L + +I
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRD-------TALTIAADKGHYKFCELLI-HRGAHIDVR 1321
Query: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
+ TPL A+ GH +V LL++ + +D++ TPL A + + V+ +K
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAG-ADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Query: 312 PSVKDDSDLE 321
+ + SD+E
Sbjct: 1381 VN-QFPSDIE 1389
Score = 44.3 bits (103), Expect = 5e-04
Identities = 35/142 (24%), Positives = 65/142 (45%), Gaps = 4/142 (2%)
Query: 15 ASQVHAAAVNGDKGALQ--RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72
+S+ A + DKG + L++ A D ++ G TPL D L++AGA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL-HLTTRHRSPKCLA 131
DV+ D+ + T L A +KG+ + ++ L+ + N D+E M + +T + KC
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLV-KEVNQFPSDIECMRYIATITDKELLKKCHQ 1408
Query: 132 LLLKFMAPGEVDTQDKNKQTAL 153
+ + + + NK ++
Sbjct: 1409 CVETIVKAKDQQAAEANKNASI 1430
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 131 bits (330), Expect = 2e-30
Identities = 135/512 (26%), Positives = 222/512 (43%), Gaps = 18/512 (3%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
K+EN AG + A +GD A+++L+ ++ + ++ G + L A +
Sbjct: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYE 252
Query: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYR-FMKLLLTRRANWMQKDLEEMTPLHLT 121
A LL A+V + +AA G Y +KLLL A+ + T L
Sbjct: 253 LAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYA 312
Query: 122 TRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE 181
+ +LL A ++ ++N T L +A + E ++L+ H + I E
Sbjct: 313 CAGGFVDIVKVLLNEGA--NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
Query: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
K A +K + VR +L+A + + E T L A DG+V V +L
Sbjct: 371 FKESALTLACYK--GHLDMVRFLLEAGADQE---HKTDEMHTALMEACMDGHVEVARLLL 425
Query: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
+ + F +PL AA GH ++ LL+ER + +D +G TPL AA+
Sbjct: 426 D-SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND-EGYTPLMEAAREGH 483
Query: 302 AETVKVFLKH-PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360
E V + L ++ ++ T+ A G +V ++ +DI++ + T
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TP 538
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420
L A+ GH+ VK LL + A V AT T L ACE GH DV L++ GA ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 421 QDGHSLLHWAALGGNADVCQILIENKINPN-VQDYAGRTPLQCAAYGGYINCMAVLMENN 479
+ G + L AA G+ Q LI N N T + A GG++ + +L+ +
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDF 511
ADP + K+G T L + G+ + + LLD+
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 127 bits (320), Expect = 4e-29
Identities = 115/449 (25%), Positives = 196/449 (43%), Gaps = 55/449 (12%)
Query: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGT 282
T L A A G+ +V VL + ++ I D TPL AA GH +V +LL++
Sbjct: 1057 TALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 283 IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML 342
S+ TPL A E V + L + K+ ++ T AA G ++++ +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 343 SLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDAT-DVMKHTPLFRACEMG 401
+ ++I+ K G + L AA++GHV VKLLL+ + ++A + ++T L AC G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV----------------------- 438
+V+ L+ A V+ + G + L AA GG A+V
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 439 ------------CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
C++LI + +V++ G TPL A+ GG+ + + +L++ AD + D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 487 KEGRTALHWSCNNGYLDAIKLLL-DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
T L + G++ ++ L+ + FP+ +E T D LL + H+
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQ------- 1408
Query: 546 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE---EENK 602
++ I K Q + K +L E+ RK A A KRE E+ K
Sbjct: 1409 -------CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRK 1461
Query: 603 RKEAEQQKGRRSPDSCRPQALPCLPSTQD 631
+K+ EQ++ + + +P+ LP +D
Sbjct: 1462 KKKEEQKRKQEEDEENKPKENSELPEDED 1490
Score = 118 bits (295), Expect = 3e-26
Identities = 111/354 (31%), Positives = 169/354 (47%), Gaps = 15/354 (4%)
Query: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFR- 256
V+ VR +LD + +N EG + L A + G + VL + + N+ N
Sbjct: 218 VNAVRKLLDEGRS---VNEHTEEGESLLCLACSAGYYELAQVLLAMHA-NVEDRGNKGDI 273
Query: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
TPL A+ G+ IV LLL + S + G T L YA F + VKV L + +
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQS-ATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
D + G T M AA G +V R +L + I+ + ++++ +AL A GH+ V+ L
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFL 391
Query: 377 LENNA-QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
LE A Q TD M HT L AC GH +V + L+ GA+V++ S L AA GG+
Sbjct: 392 LEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Query: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALH 494
++ +LIE N + G TPL AA G+ +A+L+ A+ N Q +E + TAL
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
Query: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
+C G+ + L+ A + TPL A E+++++L GA
Sbjct: 511 LACCGGFSEVADFLIKAGA-----DIELGCSTPLMEASQEGHLELVKYLLASGA 559
Score = 117 bits (292), Expect = 6e-26
Identities = 139/576 (24%), Positives = 234/576 (40%), Gaps = 51/576 (8%)
Query: 214 LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHL 273
+N Q G T L +A A G V +V VL + E NI ++ TPL AA GH ++ +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 274 LLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKG 333
LL+ S+ + L A + V+ L+ + ++ E T+ M A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
+V R +L S +NM + L AA GHV LL+E A ++ + +TP
Sbjct: 417 HVEVARLLLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 394 LFRACEMGHKDVIQTLIKGGARVDL-VDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 452
L A GH++++ L+ GA ++ ++ + L A GG ++V LI K +++
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLI--KAGADIE 532
Query: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
TPL A+ G++ + L+ + A+ + G TAL ++C NG+ D +LL
Sbjct: 533 -LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVR 572
A + +E TPL A +QF++ GA A + + G +
Sbjct: 592 A--DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 573 KAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRS---------PDSCRPQAL 623
LL+ H A R ++ E KG + P++ ++
Sbjct: 650 VV-----ELLLAH-----GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV--LSV 697
Query: 624 PCLPSTQDVPSRQSRAPSKQPPAGNVA-----QGPEPRDSRGSPGGSLGGALQKEQHVSS 678
P +Q P Q ++ + P +A Q P+ SP LG + SS
Sbjct: 698 PTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSP-ALLGVQKGTSKQKSS 756
Query: 679 DLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRELRLQIIQRE-- 736
LQ + + H C+ EG + ++EK++ L++IQ E
Sbjct: 757 SLQVADQ---DLLPSFHPYQPLECI-VEETEGKLNELGQRISAIEKAQLKSLELIQGEPL 812
Query: 737 ---------RRRKELFRKKNKAAAVIQRAWRSYQLR 763
+ R+E +KK K +Q+ R Q++
Sbjct: 813 NKDKIEELKKNREEQVQKKKKILKELQKVERQLQMK 848
Score = 104 bits (260), Expect = 3e-22
Identities = 102/342 (29%), Positives = 150/342 (43%), Gaps = 20/342 (5%)
Query: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKF 136
T+ + TAL LA G+ + +L+ R A +D + TPL L + +LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
Query: 137 MAPGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
G+++ Q ++ K T L + E V LL+ +N +V PL AA+
Sbjct: 1110 -KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS---G 1165
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
V+ ++ +L+A E G +PL A +G+V V +L S +
Sbjct: 1166 GYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------ 309
T L A G A++V LLL+R K+ G TPL AA +AE +V L
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDR-KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369
P V D T+ AA KG ++ + ID+ +K G T L A+ GH
Sbjct: 1284 NAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVR--NKKGNTPLWLASNGGH 1337
Query: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
V+LL++ A VDA D K TPL A GH V+Q L+K
Sbjct: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 72.4 bits (176), Expect = 2e-12
Identities = 86/359 (23%), Positives = 140/359 (38%), Gaps = 43/359 (11%)
Query: 22 AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-KTDHS 80
A G L +++ A + D+ G TPL+ A + + LL G D+ +++ +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
+ T L LA G + LLL R AN +++ + TPL L + +LL A
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
T K + L +A + VKLL+ S+I + + T
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN-------------------AQIET 1222
Query: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLH 260
R T L A G VV +L N+ TPL
Sbjct: 1223 NR-------------------NTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLM 1262
Query: 261 WAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
AA G+A++ +LL++ P S T L AA + ++ + + D +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
+G T A+ G DV++ ++ +D+D AD T L +A GHV V+ L++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVD--AADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 65.9 bits (159), Expect = 2e-10
Identities = 82/333 (24%), Positives = 138/333 (41%), Gaps = 12/333 (3%)
Query: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75
S + A G ++ L+ + + K D+ T LM + ++ A LL +GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
S + L LAA G+ LL+ R AN + + E TPL R + +ALLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
A T++ ++TAL + E LIK ++I ++ PL A+
Sbjct: 493 QGANINAQTEE-TQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQE--- 545
Query: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
+ V+ +L + ++ G T L +A +G+ V DVL ++
Sbjct: 546 GHLELVKYLLASGAN---VHATTATGDTALTYACENGHTDVADVLLQ-AGADLEHESEGG 601
Query: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
RTPL AA GH V L+ + + + + T + A V++ L H +
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
+G T + AA G +V+ +L +++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 60.8 bits (146), Expect = 5e-09
Identities = 95/414 (22%), Positives = 160/414 (38%), Gaps = 54/414 (13%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
+N+ N+ + + + AA G + L+ + + ++F + L
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
LD LL+AGAD TAL A G+ +LLL A
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA--------------- 429
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
+V+ + ++ L +A + E LLI+ +N+ +
Sbjct: 430 --------------------QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 181 EGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238
EG PL AA H++ A+ + A TE T L A G V D
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEE-------TQETALTLACCGGFSEVAD 522
Query: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
L + + TPL A+ GH ++V LL + + + + G T L YA +
Sbjct: 523 FLIKAGA----DIELGCSTPLMEASQEGHLELVKYLL-ASGANVHATTATGDTALTYACE 577
Query: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358
+ + V L+ + + GRT M AA G ++ ++S ++++ A+
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-DH 636
Query: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMK--HTPLFRACEMGHKDVIQTLI 410
T + A GH++ V+LLL + A D T +K T L A + GH +V+ L+
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGA--DPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 60.1 bits (144), Expect = 9e-09
Identities = 77/310 (24%), Positives = 130/310 (41%), Gaps = 24/310 (7%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
AA G G ++ L+ ++ + ++ TPL R + D LL GA+ + S
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEM--TPLHLTTRHRSPKCLALLLKFMA 138
T L LAA G +K+LL A + ++ +PL L + + LLL
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM-- 1212
Query: 139 PGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
+++ Q + N+ TAL + + E V LL+ +N+ G PL AA+
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAAS---GGY 1269
Query: 198 VHTVRCILD------AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251
R +LD A P S + T L A G+ ++L + +I
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRD-------TALTIAADKGHYKFCELLI-HRGAHIDVR 1321
Query: 252 DNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
+ TPL A+ GH +V LL++ + +D++ TPL A + + V+ +K
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAG-ADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Query: 312 PSVKDDSDLE 321
+ + SD+E
Sbjct: 1381 VN-QFPSDIE 1389
Score = 44.3 bits (103), Expect = 5e-04
Identities = 35/142 (24%), Positives = 65/142 (45%), Gaps = 4/142 (2%)
Query: 15 ASQVHAAAVNGDKGALQ--RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72
+S+ A + DKG + L++ A D ++ G TPL D L++AGA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL-HLTTRHRSPKCLA 131
DV+ D+ + T L A +KG+ + ++ L+ + N D+E M + +T + KC
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLV-KEVNQFPSDIECMRYIATITDKELLKKCHQ 1408
Query: 132 LLLKFMAPGEVDTQDKNKQTAL 153
+ + + + NK ++
Sbjct: 1409 CVETIVKAKDQQAAEANKNASI 1430
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 127 bits (318), Expect = 6e-29
Identities = 92/308 (29%), Positives = 147/308 (47%), Gaps = 4/308 (1%)
Query: 202 RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD-VLTSYESCNITSYDNLFRTPLH 260
R + A ++ L+ +D + A+ D NV + +L S + ++ + PL
Sbjct: 325 RSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLL 384
Query: 261 WAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDL 320
AA G+ QI+ LL++R + D G+ +++AA+ +T+K ++ D D
Sbjct: 385 IAAGCGNIQILQLLIKRGSRIDV-QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDK 443
Query: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
G + AA G DV + + S S+ N+ DK T LH AA G+ S K L E
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNP--NIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440
V+ + TPL A G+ D+++ L + GA ++ D+DGH LH A +V +
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500
L+ + QD G TPL A G + + L E N + +I +K GRT LH + NNG
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNG 621
Query: 501 YLDAIKLL 508
LD ++ L
Sbjct: 622 ILDVVRYL 629
Score = 112 bits (281), Expect = 1e-24
Identities = 74/238 (31%), Positives = 122/238 (51%), Gaps = 7/238 (2%)
Query: 315 KDDSDLEGRTSFMWAA---GKGSDDV--LRTMLSLKSDIDINMADKYGGTALHAAALSGH 369
+ D L+ SF+ A D+V L+ +L S+ D+N +K+G L AA G+
Sbjct: 332 RSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGN 391
Query: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHW 429
+ ++LL++ +++D D ++ A GH D ++ L + +D+ D+ G LH
Sbjct: 392 IQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHV 451
Query: 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
AA G+ADV Q+L NPN+QD TPL CAA+ GY + L E + NI+++EG
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511
Query: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
T L + GY D ++ L + A N + ++ + L A+ + EVI+ +L G
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACD--KDGHIALHLAVRRCQMEVIKTLLSQG 567
Score = 109 bits (272), Expect = 1e-23
Identities = 72/210 (34%), Positives = 104/210 (49%), Gaps = 4/210 (1%)
Query: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
G + AAG G+ +L+ ++ S ID+ DK G A++ AA GHV T+K L EN
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQ--DKGGSNAVYWAARHGHVDTLKFLSENKC 436
Query: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
+D D L A GH DV Q L G+ ++ D++ + LH AA G V +
Sbjct: 437 PLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA 496
Query: 442 LIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGY 501
L E N N+++ G TPL A+ GY + + L E+ AD N DK+G ALH +
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 502 LDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
++ IK LL F + + + TPL A
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGN--TPLHVA 584
Score = 103 bits (258), Expect = 5e-22
Identities = 80/279 (28%), Positives = 124/279 (44%), Gaps = 4/279 (1%)
Query: 214 LNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHL 273
+N + G PL A GN+ ++ +L S I D ++WAA GH +
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGS-RIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 274 LLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKG 333
L E NK D G LH AA+ A+ ++ S + D E T AA G
Sbjct: 431 LSE-NKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489
Query: 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
V + + ++ ++N+ ++ G T L A+ G+ V+ L E+ A ++A D H
Sbjct: 490 YYSVAKALC--EAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA 547
Query: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
L A +VI+TL+ G VD D+ G++ LH A GN + L E N ++ +
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607
Query: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 492
GRTPL AA G ++ + L A +G+TA
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTA 646
Score = 103 bits (256), Expect = 9e-22
Identities = 67/206 (32%), Positives = 105/206 (50%), Gaps = 4/206 (1%)
Query: 345 KSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKH--TPLFRACEMGH 402
+SD ++ D + A+ A +V ++ LL + + D KH PL A G+
Sbjct: 332 RSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGN 391
Query: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
++Q LIK G+R+D+ D+ G + ++WAA G+ D + L ENK +V+D +G L
Sbjct: 392 IQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHV 451
Query: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNE 522
AA G+ + +L ++PNIQDKE T LH + +GY K L + N N
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGC--NVNIKNR 509
Query: 523 ERYTPLDYALLGERHEVIQFMLEHGA 548
E TPL A H++++ + EHGA
Sbjct: 510 EGETPLLTASARGYHDIVECLAEHGA 535
Score = 91.7 bits (226), Expect = 3e-18
Identities = 88/348 (25%), Positives = 149/348 (42%), Gaps = 14/348 (4%)
Query: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKD--KEDQFGRTPLMYCVLADR 60
+S++ L S + A+N D + ++G+ + D + ++ G PL+
Sbjct: 332 RSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGN 391
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
+ L+K G+ ++ D A++ AA+ G+ +K L + KD LH+
Sbjct: 392 IQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHV 451
Query: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
R+ LL F + + QDK ++T LH +A++ K L + N+ I +
Sbjct: 452 AARYGHADVAQLLCSFGSNPNI--QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Query: 181 EGKIPLHWAANHKDPSAVHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDV 239
EG+ PL A+ H V C+ + LN D +G LH AV + V+
Sbjct: 510 EGETPLLTASAR----GYHDIVECLAEHGAD---LNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 240 LTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQS 299
L S + C + D TPLH A G+ IV L E N + I S+ G TPLH AA +
Sbjct: 563 LLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI-SNKYGRTPLHLAANN 620
Query: 300 NFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
+ V+ + + +G+T+ A + + V + L+ D
Sbjct: 621 GILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668
Score = 89.0 bits (219), Expect = 2e-17
Identities = 90/337 (26%), Positives = 143/337 (42%), Gaps = 14/337 (4%)
Query: 42 DKEDQFGRTPLMYCVLADRLDCADALLKA--GADVNKTDHSQRTALHLAAQKGNYRFMKL 99
D+ED F +++ + D + LL + DVN+ + L +AA GN + ++L
Sbjct: 338 DEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQL 397
Query: 100 LLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYY 159
L+ R + +D ++ RH L L + P +D +DK+ + ALH +A Y
Sbjct: 398 LIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP--LDVKDKSGEMALHVAARY 455
Query: 160 NNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDY 219
+ + +LL SN I D E + PLH AA H + + +A +N ++
Sbjct: 456 GHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH---GYYSVAKALCEAGCN---VNIKNR 509
Query: 220 EGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNK 279
EG TPL A A G +V+ L + ++ + D LH A +++ LL +
Sbjct: 510 EGETPLLTASARGYHDIVECLAEH-GADLNACDKDGHIALHLAVRRCQMEVIKTLLSQG- 567
Query: 280 SGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339
D G TPLH A + V + D S+ GRT AA G DV+R
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
+ + + ++ D G TA A H LL
Sbjct: 628 YLCLMGASVEALTTD--GKTAEDLARSEQHEHVAGLL 662
Score = 34.3 bits (77), Expect = 0.53
Identities = 31/133 (23%), Positives = 50/133 (37%)
Query: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
D+ G L V +++ LL G V+ D T LH+A + GN + L
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
Query: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164
N + TPLHL + + L A E T D L S + +
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 660
Query: 165 VKLLIKHDSNIGI 177
+ ++ D++ G+
Sbjct: 661 LLARLRKDTHRGL 673
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 124 bits (312), Expect = 3e-28
Identities = 94/303 (31%), Positives = 140/303 (46%), Gaps = 15/303 (4%)
Query: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276
+D+ GRTPLH AV G+ +V +L + + D RT LH AA GH+++ LLL+
Sbjct: 70 RDHAGRTPLHLAVLRGHAPLVRLLLQ-RGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQ 128
Query: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP----SVKDDSDLEGRTSFMWAAGK 332
R S S + G TPLH+AA L+ P + + D G T+ WAA
Sbjct: 129 RGASAAARSGT-GLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAG 187
Query: 333 GSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392
G VL + + + +D AL AA +G + ++ LL A+VDA D T
Sbjct: 188 GRLAVLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGAT 238
Query: 393 PLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 452
L A +G I+ L+ GA + D+ G S LH AA G+ Q+L+ + +
Sbjct: 239 ALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDAR 298
Query: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
D G TPL A+ G++ L++ A + +T LH + G+ + LLL
Sbjct: 299 DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
Query: 513 AFP 515
A P
Sbjct: 359 ASP 361
Score = 91.7 bits (226), Expect = 3e-18
Identities = 90/314 (28%), Positives = 137/314 (43%), Gaps = 31/314 (9%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
A G G + +L+ ++++++ D GRTPL VL LL+ GA V D +
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEER-DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRA 106
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
RTALH AA G+ R +LLL R A+ + +TPLH A LL+ PG
Sbjct: 107 GRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG 166
Query: 141 --EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH----DSNIGIPDVEGK-IPLHW----- 188
+ +D TA HW+A ++LL D + + G+ L +
Sbjct: 167 PAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARG 226
Query: 189 ----AANHKDPSAVHTVRCILDAAPTESLLNW------QDYEGRTPLHFAVADGNVTVVD 238
A + +A+ + + E LL +D GR+ LH A A G++ V
Sbjct: 227 ARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQ 286
Query: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG---ATPLHY 295
+L + + + + D L TPLH A+ GH ++ LL+R D+ G TPLH
Sbjct: 287 LLVT-QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQ----VDATGWLRKTPLHL 341
Query: 296 AAQSNFAETVKVFL 309
AA+ TV + L
Sbjct: 342 AAERGHGPTVGLLL 355
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/149 (32%), Positives = 71/149 (47%), Gaps = 4/149 (2%)
Query: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423
A G V LL A V+ D TPL A GH +++ L++ GA V VD+ G
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME----NN 479
+ LH AA G++ V ++L++ + + G TPL AA G+ A L+E
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
Query: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
A +D G TA HW+ G L ++LL
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL 196
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453
L +A G ++ L++ GA V+ D G + LH A L G+A + ++L++ D
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGY-LDAIKLLLDFA 512
AGRT L AA+ G+ +L++ A + G T LHW+ G+ L A +LL
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
Query: 513 AFPNQMENNEER-YTPLDYALLGERHEVIQFMLEHGA 548
P E + R +T +A G R V++ + GA
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA 201
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/170 (30%), Positives = 77/170 (45%), Gaps = 3/170 (1%)
Query: 5 ENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCA 64
E L G+ L + AA G +GA R ++ A D D G T L R
Sbjct: 194 ELLAAGGAGLDGALLVAAAAG-RGAALRFLLARGARVDARDGAGATALGLAAALGRSQDI 252
Query: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124
+ LL GAD D R+ALH AA +G+ ++LL+T+ A +D +TPLH +R
Sbjct: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
Query: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSN 174
+ LL A +VD ++T LH +A + V LL+ ++
Sbjct: 313 GHVEVAGCLLDRGA--QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
Score = 40.8 bits (94), Expect = 0.006
Identities = 34/118 (28%), Positives = 51/118 (43%), Gaps = 10/118 (8%)
Query: 33 LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92
+++G+ A D+ GR+ L L L+ GA+V+ D T LH A+++G
Sbjct: 254 VLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREG 313
Query: 93 NYRFMKLLLTRRA-----NWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQ 145
+ LL R A W++K TPLHL + LLL A + TQ
Sbjct: 314 HVEVAGCLLDRGAQVDATGWLRK-----TPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 123 bits (309), Expect = 7e-28
Identities = 140/544 (25%), Positives = 242/544 (44%), Gaps = 35/544 (6%)
Query: 18 VHAAAVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76
+H AA G ++++ +S + + D +G TPL V ++++ LL GA+ N
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE-MTPLHLTTRHRSPKCLALLLK 135
+ + LH+A Q N MK+LL R + + E T + + + + L +LLK
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-------EGK-IPLH 187
A + +K +H +A+ + E ++++++ G GK PLH
Sbjct: 187 KGA--KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
Query: 188 WAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR-TPLHFAVADGNVTVVDVLTSYESC 246
A + D + C+ + A + + +GR T +HFA G +V ++ S S
Sbjct: 245 LAVQNGDLEMIK--MCLDNGAQIDPV-----EKGRCTAIHFAATQGATEIVKLMISSYSG 297
Query: 247 N---ITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303
+ + + D T LH A+L H ++ L+ + DS+G +PL A S
Sbjct: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVG-ADINKIDSEGRSPLILATASASWN 356
Query: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGK--GSDDVLRTMLSLKSDIDINM-ADKYGGTA 360
V + L + D D GR + G ++ + ++ ++ M D G T
Sbjct: 357 IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTP 416
Query: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV- 419
LH A G +V LL N + + K +PL A G + Q L++ + L+
Sbjct: 417 LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476
Query: 420 --DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
D G + LH AA G+ V Q+L++ K + D+ G T L A+ GGY M V+++
Sbjct: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLK-KGALFLSDHNGWTALHHASMGGYTQTMKVILD 535
Query: 478 NNAD-PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536
N + D++G TALH++ G+ A+ LLL A + N+++ + L AL +R
Sbjct: 536 TNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA---DIVLNKQQASFLHLALHNKR 592
Query: 537 HEVI 540
EV+
Sbjct: 593 KEVV 596
Score = 106 bits (265), Expect = 8e-23
Identities = 122/519 (23%), Positives = 224/519 (43%), Gaps = 66/519 (12%)
Query: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
+++ N ++ + +H A + ++ L+ + + E + G T ++ +
Sbjct: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177
Query: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLL--------TRRANWMQKDL 112
+ LLK GA K++ +H AA G+ M+++L +R+ + +
Sbjct: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237
Query: 113 EEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHD 172
+ TPLHL ++ + + + L A ++D +K + TA+H++A E VKL+I
Sbjct: 238 GKATPLHLAVQNGDLEMIKMCLDNGA--QIDPVEKGRCTAIHFAATQGATEIVKLMISSY 295
Query: 173 SN----IGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
S + D + LH A+ +H H + L + + +N D EGR+PL
Sbjct: 296 SGSVDIVNTTDGCHETMLHRASLFDH------HELADYLISVGAD--INKIDSEGRSPLI 347
Query: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL----LGHAQIVHLLLERNKSGT 282
A A + +V++L S + + DN R LH L + + + +++ K
Sbjct: 348 LATASASWNIVNLLLS-KGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELV 406
Query: 283 IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML 342
+ D+ G TPLHYA + +V L + ++ +AA G + + +L
Sbjct: 407 MDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLL 466
Query: 343 SLKSDID-INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401
SD +N D +G T LH AA +GH V+LLL+ A LF
Sbjct: 467 QDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA------------LF------ 508
Query: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN-PNVQDYAGRTPL 460
L D +G + LH A++GG +++++ + + D G T L
Sbjct: 509 ----------------LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTAL 552
Query: 461 QCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
AA G+ +A+L+ +NAD + +K+ + LH + +N
Sbjct: 553 HFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHN 590
Score = 96.7 bits (239), Expect = 9e-20
Identities = 103/424 (24%), Positives = 181/424 (42%), Gaps = 25/424 (5%)
Query: 146 DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205
D T LH + N E VK L+ +N + + PLH A + + + +L
Sbjct: 95 DDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVM---KVLL 151
Query: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHWAA 263
+ + +N + G T + A N + +L + C + P+H AA
Sbjct: 152 EHRTID--VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCF---PIHQAA 206
Query: 264 LLGHAQIVHLLL----ERNKSGTIPSDSQG---ATPLHYAAQSNFAETVKVFLKHPSVKD 316
G + + ++L E S + + ATPLH A Q+ E +K+ L + + D
Sbjct: 207 FSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQID 266
Query: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKS-DIDI-NMADKYGGTALHAAALSGHVSTVK 374
+ T+ +AA +G+ ++++ M+S S +DI N D T LH A+L H
Sbjct: 267 PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELAD 326
Query: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA--- 431
L+ A ++ D +PL A +++ L+ GA+VD+ D G + LH
Sbjct: 327 YLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQP 386
Query: 432 LGGNADVCQILIENKINPNV--QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
G + + +I V +D G TPL A G + L+ N + + K+
Sbjct: 387 YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 446
Query: 490 RTALHWSCNNGYLDAI-KLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
++ LH++ + G ++ +LL D + E + TPL A +V+Q +L+ GA
Sbjct: 447 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 506
Query: 549 LSIA 552
L ++
Sbjct: 507 LFLS 510
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 120 bits (302), Expect = 4e-27
Identities = 105/360 (29%), Positives = 160/360 (44%), Gaps = 37/360 (10%)
Query: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTES 212
LH +A NN ++ LI N + G++ LHWAA AV R +L+
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAV---RLLLE------ 69
Query: 213 LLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVH 272
H A D V LT C L +A GH +I+
Sbjct: 70 -------------HEAAVDEE-DAVGALTEARLC-------FGMNALLLSAWFGHLRILQ 108
Query: 273 LLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLK--HPSVKDDSDLEGRTSFMWA 329
+L+ N I +S+ G T LH AAQ + ++ D D GRT+F A
Sbjct: 109 ILV--NSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 166
Query: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
A G D L ++ S D N+ DK G TALH AA GH++ ++ L++ ++ +
Sbjct: 167 AEHGQLDALDFLVG--SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
Query: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449
T L A H D +Q L++ G+ V+ + Q S LH+AAL G+ DV ++LI
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
Query: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
NV D+ G +PL A + + +L+ +++D N D +T LH + + + D +LL
Sbjct: 285 NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344
Score = 105 bits (262), Expect = 2e-22
Identities = 102/377 (27%), Positives = 165/377 (43%), Gaps = 25/377 (6%)
Query: 14 LASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
L Q+H AA + G +Q LI G + GR L + A LL+ A
Sbjct: 15 LERQLHEAARQNNVGRMQELI-GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAA 73
Query: 74 VNKTDHSQR----------TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
V++ D AL L+A G+ R +++L+ A + + +T LH +
Sbjct: 74 VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
Query: 124 HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK 183
LA +++ + +D DK +TA H +A + + + L+ + + D EG
Sbjct: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
Query: 184 IPLHWAANHKDPSAVHTVRCI-LDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD-VLT 241
LH AA + + + I LD L Q+ EG T LH A + V +L
Sbjct: 194 TALHLAAGRGHMAVLQRLVDIGLD-------LEEQNAEGLTALHSAAGGSHPDCVQLLLR 246
Query: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
+ + N + NL + LH+AAL G + +L+ + D QGA+PLH A + NF
Sbjct: 247 AGSTVNALTQKNL--SCLHYAALSGSEDVSRVLIHAGGCANV-VDHQGASPLHLAVRHNF 303
Query: 302 AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL 361
V++ + S + D +T AA D+ +L + +D+N+ DK G TAL
Sbjct: 304 PALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI--AGVDLNLRDKQGKTAL 361
Query: 362 HAAALSGHVSTVKLLLE 378
A S HVS V ++++
Sbjct: 362 AVAVRSNHVSLVDMIIK 378
Score = 99.8 bits (247), Expect = 1e-20
Identities = 86/333 (25%), Positives = 144/333 (43%), Gaps = 14/333 (4%)
Query: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284
LH A NV + L N + +++ R LHWAA GH Q V LLLE +++
Sbjct: 19 LHEAARQNNVGRMQELIG-RRVNTRARNHVGRVALHWAAGAGHEQAVRLLLE-HEAAVDE 76
Query: 285 SDSQGA----------TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS 334
D+ GA L +A +++ + + +G T AA KG
Sbjct: 77 EDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGH 136
Query: 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394
VL ++ D+ ++ DK G TA H AA G + + L+ + + D +T L
Sbjct: 137 VPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTAL 196
Query: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454
A GH V+Q L+ G ++ + +G + LH AA G + D Q+L+ N
Sbjct: 197 HLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQ 256
Query: 455 AGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAF 514
+ L AA G + VL+ N+ D +G + LH + + + ++LL++ +
Sbjct: 257 KNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD 316
Query: 515 PNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
N ++N ++ TPL A ++ +L G
Sbjct: 317 VNAVDNRQQ--TPLHLAAEHAWQDIADMLLIAG 347
Score = 92.4 bits (228), Expect = 2e-18
Identities = 91/375 (24%), Positives = 163/375 (43%), Gaps = 43/375 (11%)
Query: 142 VDTQDKNK--QTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP---LHWAANHKDPS 196
V+T+ +N + ALHW+A + + V+LL++H++ + D G + L + N S
Sbjct: 39 VNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLS 98
Query: 197 A-VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD-VLTSYESCNITSYDNL 254
A +R + + + ++ + +G T LH A G+V V+ ++ E + D L
Sbjct: 99 AWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKL 158
Query: 255 FRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSV 314
RT H AA G + L+ + D +G T LH AA ++ +
Sbjct: 159 GRTAFHRAAEHGQLDALDFLVGSGCDHNV-KDKEGNTALHLAAGRGHMAVLQRLVDIGLD 217
Query: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
++ + EG T+ AAG D ++ L L++ +N + + LH AALS
Sbjct: 218 LEEQNAEGLTALHSAAGGSHPDCVQ--LLLRAGSTVNALTQKNLSCLHYAALS------- 268
Query: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
G +DV + LI G ++VD G S LH A
Sbjct: 269 --------------------------GSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
Query: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494
+ ++LI + + N D +TPL AA + + +L+ D N++DK+G+TAL
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362
Query: 495 WSCNNGYLDAIKLLL 509
+ + ++ + +++
Sbjct: 363 VAVRSNHVSLVDMII 377
Score = 86.7 bits (213), Expect = 9e-17
Identities = 73/277 (26%), Positives = 123/277 (44%), Gaps = 14/277 (5%)
Query: 18 VHAAAVNGDKGALQRLIVG-NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76
+H AA G L ++ D D+ GRT +LD D L+ +G D N
Sbjct: 128 LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNV 187
Query: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKF 136
D TALHLAA +G+ ++ L+ + +++ E +T LH P C+ LLL+
Sbjct: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLR- 246
Query: 137 MAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPS 196
A V+ + + LH++A + + ++LI + D +G PLH A H P+
Sbjct: 247 -AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 305
Query: 197 AVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFR 256
VR +++ ++S +N D +TPLH A + D+L ++ D +
Sbjct: 306 ---LVRLLIN---SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDLNLRDKQGK 358
Query: 257 TPLHWAALLGHAQIVHLLLERNK----SGTIPSDSQG 289
T L A H +V ++++ ++ PSD G
Sbjct: 359 TALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSG 395
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 120 bits (300), Expect = 7e-27
Identities = 93/304 (30%), Positives = 148/304 (48%), Gaps = 26/304 (8%)
Query: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
LG+ ++V LLLE + S+S G TPL YAA + + V + K + D D G+
Sbjct: 895 LGYTEMVALLLEFGANVDASSES-GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
Query: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375
+ + AA +G +V++ ++ D MA + G AL AAA G+ V
Sbjct: 954 ALVHAALRGHLEVVKFLIQC----DWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSY 1009
Query: 376 LLE---------NNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425
LL+ AQ+++ D + T L A G +V + L++ GA V ++ G
Sbjct: 1010 LLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV 1069
Query: 426 LLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
L G+ + +L+ + + N+ D GRTPL AA G++ + L+ A +
Sbjct: 1070 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM 1129
Query: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
DKEG TAL W+C G+L ++ L+D A + + N TPLD A EV+QF+++
Sbjct: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR--TPLDLAAFYGDAEVVQFLVD 1187
Query: 546 HGAL 549
HGA+
Sbjct: 1188 HGAM 1191
Score = 102 bits (253), Expect = 2e-21
Identities = 89/310 (28%), Positives = 131/310 (42%), Gaps = 54/310 (17%)
Query: 221 GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280
G TPL +A A G +++V VL + + D + L AAL GH ++V L++ +
Sbjct: 918 GLTPLGYAAAAGYLSIV-VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-- 974
Query: 281 GTIPSDSQGATPLHYAAQS--------NFAETVKVFLKHPSVKDDSDLE----------- 321
T+ QG +A Q + E V L P KD+ ++E
Sbjct: 975 WTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE-KDEEEVERAQINSFDSLW 1033
Query: 322 GRTSFMWAAGKGSDDVLRTMLS-------------------------------LKSDIDI 350
G T+ AAG+G +V R +L L D+
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 1093
Query: 351 NMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLI 410
NMADK G T L AA GH+ TV LL A + D T L AC GH V+++L+
Sbjct: 1094 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
Query: 411 KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 470
GA D D++G + L AA G+A+V Q L+++ DY+G PL A +
Sbjct: 1154 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213
Query: 471 CMAVLMENNA 480
+ L++ A
Sbjct: 1214 VVVTLLKKGA 1223
Score = 88.6 bits (218), Expect = 2e-17
Identities = 108/395 (27%), Positives = 155/395 (39%), Gaps = 37/395 (9%)
Query: 67 LLKAGADVNKTDHSQRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124
L+ GA++N A L Q G + LLL AN +TPL
Sbjct: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAA 928
Query: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184
+ LL K A +VD DKN Q AL +A + E VK LI+ D + G+
Sbjct: 929 GYLSIVVLLCKKRA--KVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA-----GQQ 981
Query: 185 PLHWAANHKDPSAV---------HTVRCILDAAPTES-------LLNWQDYEGRTPLHFA 228
+ +H A+ V +LD + + ++ G T L A
Sbjct: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
Query: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
G + V +L + + + PL GH QIV LLL + +D Q
Sbjct: 1042 AGRGKLEVCRLLLE-QGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM-ADKQ 1099
Query: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
G TPL AA TV L + D EG T+ WA KG V+R+++ +
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
Query: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
D ADK G T L AA G V+ L+++ A ++ D PL RA + V+ T
Sbjct: 1160 D--HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
Query: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
L+K GA++ WA D+ IL+
Sbjct: 1218 LLKKGAKIGPAT--------WAMATSKPDIMIILL 1244
Score = 66.2 bits (160), Expect = 1e-10
Identities = 55/181 (30%), Positives = 80/181 (44%), Gaps = 2/181 (1%)
Query: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
AA K + RL++ A + ++ G PL V D LL GADVN D
Sbjct: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
Query: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
RT L +AA +G+ + LL + A+ D E +T L + L+ A
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA-- 1157
Query: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
D DKN +T L +A+Y + E V+ L+ H + I D G PL A ++ S V T
Sbjct: 1158 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
Query: 201 V 201
+
Sbjct: 1218 L 1218
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 8/206 (3%)
Query: 35 VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNY 94
V + + + +G T L +L+ LL+ GA V + + L ++G++
Sbjct: 1021 VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
Query: 95 RFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALH 154
+ + LLLT A+ D + TPL + + LL A + DK TAL
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGA--SIALMDKEGLTALS 1138
Query: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLL 214
W+ + V+ L+ + + D G+ PL AA + D V+ ++D +++
Sbjct: 1139 WACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGD---AEVVQFLVDHG---AMI 1192
Query: 215 NWQDYEGRTPLHFAVADGNVTVVDVL 240
DY G PL AV N +VV L
Sbjct: 1193 EHVDYSGMRPLDRAVGCRNTSVVVTL 1218
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 2/107 (1%)
Query: 405 VIQTLIKGGARVDLVDQ--DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
V + LI GGA ++ + + +L + G ++ +L+E N + +G TPL
Sbjct: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
Query: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
AA GY++ + +L + A + DK G+ AL + G+L+ +K L+
Sbjct: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 971
Score = 40.4 bits (93), Expect = 0.007
Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 21 AAVNGDKGALQRLIVGNS--ALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTD 78
AA G G + L+ + AL DKE G T L + L L +L+ GA + D
Sbjct: 1107 AASEGHLGTVDFLLAQGASIALMDKE---GLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163
Query: 79 HSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
+ RT L LAA G+ ++ L+ A D M PL R+ + LLK
Sbjct: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
Score = 40.0 bits (92), Expect = 0.010
Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 435 NADVCQILIENKINPNVQ-DYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQDKEGRTA 492
N V ++LI N N + + P+ C ++ GY +A+L+E A+ + + G T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 493 LHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
L ++ GYL + LL A + ++ N + L +A L EV++F+++
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ--CALVHAALRGHLEVVKFLIQ 972
Score = 30.4 bits (67), Expect = 7.7
Identities = 22/74 (29%), Positives = 30/74 (40%)
Query: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
R +V N A D D+ GRTPL + L+ GA + D+S L A
Sbjct: 1150 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC 1209
Query: 92 GNYRFMKLLLTRRA 105
N + LL + A
Sbjct: 1210 RNTSVVVTLLKKGA 1223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,244,519
Number of Sequences: 37866
Number of extensions: 1696956
Number of successful extensions: 18146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 393
Number of HSP's successfully gapped in prelim test: 222
Number of HSP's that attempted gapping in prelim test: 8459
Number of HSP's gapped (non-prelim): 3919
length of query: 895
length of database: 18,247,518
effective HSP length: 111
effective length of query: 784
effective length of database: 14,044,392
effective search space: 11010803328
effective search space used: 11010803328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.