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Search of human proteins with 34304356
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa... 884 0.0
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa... 800 0.0
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa... 800 0.0
gi|54144631 phosphatase and actin regulator 1 [Homo sapiens] 363 e-100
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s... 225 6e-59
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s... 225 6e-59
gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s... 224 1e-58
gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s... 224 1e-58
gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s... 214 1e-55
gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s... 214 1e-55
gi|56549694 enabled homolog isoform a [Homo sapiens] 51 2e-06
gi|39930375 enabled homolog isoform b [Homo sapiens] 51 2e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 50 3e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 50 3e-06
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 47 4e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 47 5e-05
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 46 8e-05
gi|148746195 trichohyalin [Homo sapiens] 45 1e-04
gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens] 45 1e-04
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 45 1e-04
gi|62244004 modulator of estrogen induced transcription isoform ... 45 1e-04
gi|63176611 modulator of estrogen induced transcription isoform ... 45 1e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 45 1e-04
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 45 1e-04
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 45 2e-04
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 44 2e-04
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 2e-04
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 44 2e-04
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 44 3e-04
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 44 4e-04
>gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
sapiens]
Length = 448
Score = 884 bits (2284), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG
Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
Query: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 120
RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG
Sbjct: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 120
Query: 121 TDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPS 180
TDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPS
Sbjct: 121 TDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPS 180
Query: 181 RVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALEN 240
RVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALEN
Sbjct: 181 RVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALEN 240
Query: 241 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 300
KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP
Sbjct: 241 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 300
Query: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360
SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE
Sbjct: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360
Query: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420
RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA
Sbjct: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420
Query: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448
IRKELNEYKSNEMEVHASSKHLTRFHRP
Sbjct: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448
>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
sapiens]
Length = 518
Score = 800 bits (2067), Expect = 0.0
Identities = 431/520 (82%), Positives = 433/520 (83%), Gaps = 74/520 (14%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG
Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
Query: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS------------ 108
RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS
Sbjct: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 120
Query: 109 ----------------------------EDAQPGSPLAT---------GTDQVSLDKP-- 129
E+A GS L T G D SLD P
Sbjct: 121 TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGAD--SLDSPPR 178
Query: 130 ---------------------LSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSP 168
SS + GQATLFQASSMKSADPSLRGQLSTPTGSP
Sbjct: 179 PLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSP 238
Query: 169 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 228
HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER
Sbjct: 239 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 298
Query: 229 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 288
EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK
Sbjct: 299 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 358
Query: 289 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 348
KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI
Sbjct: 359 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 418
Query: 349 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 408
LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK
Sbjct: 419 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 478
Query: 409 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
Sbjct: 479 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 518
>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
sapiens]
Length = 559
Score = 800 bits (2067), Expect = 0.0
Identities = 431/520 (82%), Positives = 433/520 (83%), Gaps = 74/520 (14%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG
Sbjct: 42 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 101
Query: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS------------ 108
RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS
Sbjct: 102 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 161
Query: 109 ----------------------------EDAQPGSPLAT---------GTDQVSLDKP-- 129
E+A GS L T G D SLD P
Sbjct: 162 TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGAD--SLDSPPR 219
Query: 130 ---------------------LSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSP 168
SS + GQATLFQASSMKSADPSLRGQLSTPTGSP
Sbjct: 220 PLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSP 279
Query: 169 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 228
HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER
Sbjct: 280 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 339
Query: 229 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 288
EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK
Sbjct: 340 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 399
Query: 289 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 348
KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI
Sbjct: 400 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 459
Query: 349 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 408
LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK
Sbjct: 460 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 519
Query: 409 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
Sbjct: 520 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
Length = 580
Score = 363 bits (933), Expect = e-100
Identities = 233/495 (47%), Positives = 302/495 (61%), Gaps = 62/495 (12%)
Query: 8 RPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREEL 67
R + LV G TPP+RR SK A LGRIFKPWKWRKKK+EK K T++ALE+K++ RQ REEL
Sbjct: 94 RSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREEL 153
Query: 68 IKKGLL-EMMEQDAESKTCNPDGGPRSVQS--------------EP-PTPKS----ETLT 107
IK+G+L E+ ++D E N + + QS EP P P+ E L
Sbjct: 154 IKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQ 213
Query: 108 SEDAQ----PGSPLATGTDQVSLDKPLSSAAHLD----DAGQATLFQASSMKSAD----- 154
D PG+P+ V L PL + +L ++ KS
Sbjct: 214 PSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQ 273
Query: 155 ------PS-LRGQLSTPTGSPHL--TTVHRPLPPS--RVIEELHRALA-TKHRQDSFQGR 202
PS ++ QL + HL TT P+ PS R+I+EL++ LA T R +S + R
Sbjct: 274 HHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQR 333
Query: 203 ESKGSPKKRLDVRLSRTSSVERGKEREEAWSFD-GALENKRTAAKESEENKENLIINSEL 261
+ +S + G +A + T E ++NKEN+ S+
Sbjct: 334 VPCSTSY--------HSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDY 385
Query: 262 KDDLLLY-------QDEEALNDSIISGTLPRK-CKKELLAVKLRNRPSKQELEDRNIFPR 313
+D LY +++E + S+ + +L K C+K+ LA+KL NRPSK+ELE++NI PR
Sbjct: 386 EDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPR 445
Query: 314 RTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLN 373
+TDEER E+RQQI KL++RLSQRP EELE+RNILK RN+Q EQEE+REIK+RLTRKL+
Sbjct: 446 QTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLS 505
Query: 374 QRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEM 433
QRPTV+ELR+RKILIRFSDYVEVA AQDYDRRADKPWTRL+AADKAAIRKELNE+KS EM
Sbjct: 506 QRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEM 565
Query: 434 EVHASSKHLTRFHRP 448
EVH S+HLTRFHRP
Sbjct: 566 EVHELSRHLTRFHRP 580
>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
sapiens]
Length = 634
Score = 225 bits (574), Expect = 6e-59
Identities = 167/458 (36%), Positives = 235/458 (51%), Gaps = 34/458 (7%)
Query: 15 GIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLE 74
G PP+++N+K P K +N + S+ KK G +
Sbjct: 187 GDEVPPIKKNTKAPGKQAPVPPPK-PASRNTTREAAGSSHSKKTTGSKASASPSTSSTSS 245
Query: 75 MMEQDAESK-----TCNPDGGPRSVQSEPPTP--KSETLTSEDAQ-PGSPLATGTDQVSL 126
+ E+ T G R +P T S+T TS + G P T + L
Sbjct: 246 RPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKL 305
Query: 127 DKPLSSAAHLDDAGQATLFQASSMKSADPS-------LRGQLSTPTGSPH-LTTVHRPLP 178
++ + A + ++ + A PS L Q T + +P L +V LP
Sbjct: 306 EQTVPGAEEQNTGKFKSMVPPPPVAPA-PSPLAPPLPLEDQCITASDTPVVLVSVGADLP 364
Query: 179 PSRVI-EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGA 237
S + +L A +R + G G R + + T E GK + +
Sbjct: 365 VSALDPSQLLWAEEPTNRTTLYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLM 420
Query: 238 LENKRTAAKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKE 290
E+ + + +E N D +LY +DE+ +S ++ + R+ +
Sbjct: 421 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---D 477
Query: 291 LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK 350
LA+KL NRPSK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILK
Sbjct: 478 TLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILK 537
Query: 351 QRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPW 410
Q+N++ EQE + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW
Sbjct: 538 QKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPW 596
Query: 411 TRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
RL+ ADKAAIRKELNE+KS EMEVH S+ TRFHRP
Sbjct: 597 ARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 634
Score = 84.7 bits (208), Expect = 2e-16
Identities = 39/83 (46%), Positives = 63/83 (75%), Gaps = 2/83 (2%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59
+D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 8 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67
Query: 60 GRQGREELIKKGLL-EMMEQDAE 81
RQ REELI++G+L E+ +QD +
Sbjct: 68 TRQSREELIRRGVLKELPDQDGD 90
>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
sapiens]
Length = 645
Score = 225 bits (574), Expect = 6e-59
Identities = 167/458 (36%), Positives = 235/458 (51%), Gaps = 34/458 (7%)
Query: 15 GIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLE 74
G PP+++N+K P K +N + S+ KK G +
Sbjct: 198 GDEVPPIKKNTKAPGKQAPVPPPK-PASRNTTREAAGSSHSKKTTGSKASASPSTSSTSS 256
Query: 75 MMEQDAESK-----TCNPDGGPRSVQSEPPTP--KSETLTSEDAQ-PGSPLATGTDQVSL 126
+ E+ T G R +P T S+T TS + G P T + L
Sbjct: 257 RPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKL 316
Query: 127 DKPLSSAAHLDDAGQATLFQASSMKSADPS-------LRGQLSTPTGSPH-LTTVHRPLP 178
++ + A + ++ + A PS L Q T + +P L +V LP
Sbjct: 317 EQTVPGAEEQNTGKFKSMVPPPPVAPA-PSPLAPPLPLEDQCITASDTPVVLVSVGADLP 375
Query: 179 PSRVI-EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGA 237
S + +L A +R + G G R + + T E GK + +
Sbjct: 376 VSALDPSQLLWAEEPTNRTTLYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLM 431
Query: 238 LENKRTAAKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKE 290
E+ + + +E N D +LY +DE+ +S ++ + R+ +
Sbjct: 432 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---D 488
Query: 291 LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK 350
LA+KL NRPSK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILK
Sbjct: 489 TLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILK 548
Query: 351 QRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPW 410
Q+N++ EQE + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW
Sbjct: 549 QKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPW 607
Query: 411 TRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
RL+ ADKAAIRKELNE+KS EMEVH S+ TRFHRP
Sbjct: 608 ARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 645
Score = 84.7 bits (208), Expect = 2e-16
Identities = 39/83 (46%), Positives = 63/83 (75%), Gaps = 2/83 (2%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59
+D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 19 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 78
Query: 60 GRQGREELIKKGLL-EMMEQDAE 81
RQ REELI++G+L E+ +QD +
Sbjct: 79 TRQSREELIRRGVLKELPDQDGD 101
>gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
sapiens]
Length = 554
Score = 224 bits (571), Expect = 1e-58
Identities = 120/208 (57%), Positives = 152/208 (73%), Gaps = 4/208 (1%)
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK---KELLAVKLRNRP 300
+A E E ++E +S+ +L DE+ D SG K ++ LA+KL NRP
Sbjct: 348 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRP 407
Query: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360
SK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE
Sbjct: 408 SKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEA 467
Query: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420
+ E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAA
Sbjct: 468 KMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAA 526
Query: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448
IRKELNE+KS EMEVH S+ TRFHRP
Sbjct: 527 IRKELNEFKSTEMEVHEESRQFTRFHRP 554
Score = 87.4 bits (215), Expect = 2e-17
Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59
+D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 8 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67
Query: 60 GRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPL 117
RQ REELI++G+L E+ +QD + + G E T + + SE+
Sbjct: 68 TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE------- 120
Query: 118 ATGTDQVS-LDKPLSSAAHLDDAGQATLFQASSMK-SADPSLRGQLSTPTGS 167
G VS PL A AG + + + K SA PS S P S
Sbjct: 121 --GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKAS 170
>gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
sapiens]
Length = 565
Score = 224 bits (571), Expect = 1e-58
Identities = 120/208 (57%), Positives = 152/208 (73%), Gaps = 4/208 (1%)
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK---KELLAVKLRNRP 300
+A E E ++E +S+ +L DE+ D SG K ++ LA+KL NRP
Sbjct: 359 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRP 418
Query: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360
SK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE
Sbjct: 419 SKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEA 478
Query: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420
+ E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAA
Sbjct: 479 KMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAA 537
Query: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448
IRKELNE+KS EMEVH S+ TRFHRP
Sbjct: 538 IRKELNEFKSTEMEVHEESRQFTRFHRP 565
Score = 87.4 bits (215), Expect = 2e-17
Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59
+D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 19 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 78
Query: 60 GRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPL 117
RQ REELI++G+L E+ +QD + + G E T + + SE+
Sbjct: 79 TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE------- 131
Query: 118 ATGTDQVS-LDKPLSSAAHLDDAGQATLFQASSMK-SADPSLRGQLSTPTGS 167
G VS PL A AG + + + K SA PS S P S
Sbjct: 132 --GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKAS 181
>gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo
sapiens]
Length = 712
Score = 214 bits (546), Expect = 1e-55
Identities = 131/281 (46%), Positives = 174/281 (61%), Gaps = 14/281 (4%)
Query: 176 PLPPSRVIEELHRALATK-HRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSF 234
PLP + ++E HRA + DSF S + L + + + +E E+
Sbjct: 438 PLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPS 497
Query: 235 DGALENKRTAA-------KESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKC 287
+ E T+ EE KE+ + + Y+DEE ++S S +
Sbjct: 498 TFSEEMTPTSVIPKLPQCLREEEEKES----DSDSEGPIQYRDEEDEDESYQSALANKVK 553
Query: 288 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRN 347
+K+ LA+KL +RPS+ EL + N +P ++ EE EIR QI L +RLSQRP EELE+RN
Sbjct: 554 RKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRN 612
Query: 348 ILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRAD 407
IL+ +N+ Q E+REIK+RLTRKL+QRPTV EL RKIL RF++YVEV AQDYDRRAD
Sbjct: 613 ILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKIL-RFNEYVEVTDAQDYDRRAD 671
Query: 408 KPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
KPWT+L+ ADKAAIRKELNE+KS+EMEVH SKH TR+HRP
Sbjct: 672 KPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 712
Score = 79.7 bits (195), Expect = 5e-15
Identities = 65/189 (34%), Positives = 92/189 (48%), Gaps = 30/189 (15%)
Query: 14 SGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMAGRQGREELIKKG- 71
+G TPP +R SK + G+IFKPWKWRKKK ++K K+T+ LE+K++ R+ REEL+K+G
Sbjct: 34 AGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGV 93
Query: 72 LLEMMEQDAE-----------SKTCNPDGGPRS-----VQSEPPTPKS-----------E 104
LLE EQ E + P G RS V+ EP S +
Sbjct: 94 LLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKK 153
Query: 105 TLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTP 164
L S +QP S + + V L L + +A+ QA S+ + R +ST
Sbjct: 154 RLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTS 213
Query: 165 -TGSPHLTT 172
T +P TT
Sbjct: 214 ITTAPAATT 222
>gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo
sapiens]
Length = 702
Score = 214 bits (546), Expect = 1e-55
Identities = 131/281 (46%), Positives = 174/281 (61%), Gaps = 14/281 (4%)
Query: 176 PLPPSRVIEELHRALATK-HRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSF 234
PLP + ++E HRA + DSF S + L + + + +E E+
Sbjct: 428 PLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPS 487
Query: 235 DGALENKRTAA-------KESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKC 287
+ E T+ EE KE+ + + Y+DEE ++S S +
Sbjct: 488 TFSEEMTPTSVIPKLPQCLREEEEKES----DSDSEGPIQYRDEEDEDESYQSALANKVK 543
Query: 288 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRN 347
+K+ LA+KL +RPS+ EL + N +P ++ EE EIR QI L +RLSQRP EELE+RN
Sbjct: 544 RKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRN 602
Query: 348 ILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRAD 407
IL+ +N+ Q E+REIK+RLTRKL+QRPTV EL RKIL RF++YVEV AQDYDRRAD
Sbjct: 603 ILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKIL-RFNEYVEVTDAQDYDRRAD 661
Query: 408 KPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
KPWT+L+ ADKAAIRKELNE+KS+EMEVH SKH TR+HRP
Sbjct: 662 KPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 702
Score = 79.7 bits (195), Expect = 5e-15
Identities = 65/189 (34%), Positives = 92/189 (48%), Gaps = 30/189 (15%)
Query: 14 SGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMAGRQGREELIKKG- 71
+G TPP +R SK + G+IFKPWKWRKKK ++K K+T+ LE+K++ R+ REEL+K+G
Sbjct: 24 AGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGV 83
Query: 72 LLEMMEQDAE-----------SKTCNPDGGPRS-----VQSEPPTPKS-----------E 104
LLE EQ E + P G RS V+ EP S +
Sbjct: 84 LLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKK 143
Query: 105 TLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTP 164
L S +QP S + + V L L + +A+ QA S+ + R +ST
Sbjct: 144 RLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTS 203
Query: 165 -TGSPHLTT 172
T +P TT
Sbjct: 204 ITTAPAATT 212
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 19/172 (11%)
Query: 272 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELE-----------DRNIFPRRTDEERQ 320
E LN TLPR+ + L +++N PS++ELE + + R + ER
Sbjct: 109 EVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 321 EIRQQIEMKLSKRLSQRPAVEE--LERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTV 378
E + +L + +R +E+ LER ++R ++ E++ER E ++RL R+
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 379 DELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR----LSAADKAAIRKELN 426
E ++R+ L R + + Q+ R W R SAA A++ LN
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLN 278
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 19/172 (11%)
Query: 272 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELE-----------DRNIFPRRTDEERQ 320
E LN TLPR+ + L +++N PS++ELE + + R + ER
Sbjct: 109 EVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 321 EIRQQIEMKLSKRLSQRPAVEE--LERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTV 378
E + +L + +R +E+ LER ++R ++ E++ER E ++RL R+
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 379 DELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR----LSAADKAAIRKELN 426
E ++R+ L R + + Q+ R W R SAA A++ LN
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLN 278
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 50.4 bits (119), Expect = 3e-06
Identities = 57/251 (22%), Positives = 107/251 (42%), Gaps = 29/251 (11%)
Query: 202 RESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKE-------------- 247
+E +P+K S E+ K E+A + D +T AKE
Sbjct: 727 KEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK 786
Query: 248 ---SEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQE 304
EE K S LK+D + E + + S P K +++ VK++ P K E
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS---PVKEEEKPQEVKVKEPPKKAE 843
Query: 305 LEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTE-QEERRE 363
E P+ EE+++ +++ + K+ + +P VEE + + K + + E ++E E
Sbjct: 844 EEKAPATPK--TEEKKDSKKE---EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898
Query: 364 IKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRK 423
K+++ + P E+++ + + EVAK + D +A +P + A +K
Sbjct: 899 DKKKVPTPEKEAPAKVEVKED---AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955
Query: 424 ELNEYKSNEME 434
+ E K+ + E
Sbjct: 956 DTKEEKAKKPE 966
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 50.4 bits (119), Expect = 3e-06
Identities = 47/229 (20%), Positives = 103/229 (44%), Gaps = 14/229 (6%)
Query: 223 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 282
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 283 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 338
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 339 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 398
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 399 AQDYDRR-ADKPWTRLSAADKAAIRKE--LNEYKSNEMEVHASSKHLTR 444
Q+Y RR ++ L + ++++ L E + EME H ++ L R
Sbjct: 464 EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 47.0 bits (110), Expect = 4e-05
Identities = 54/188 (28%), Positives = 80/188 (42%), Gaps = 37/188 (19%)
Query: 200 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 259
+G++ K KKR ERGKERE E +R +E E K
Sbjct: 58 RGKKEKKKRKKR-----------ERGKERERKRK---EREKQRKERREKERRKR------ 97
Query: 260 ELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEER 319
+ E+ + G RK KKE K R R +KQ E R RR + R
Sbjct: 98 ---------KKEKKKRERKQRGRRERKKKKER---KERERENKQRRE-RKRKKRRKKKRR 144
Query: 320 QEIRQQIE--MKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPT 377
+E +++ E + KR ++ E +R K+R + E++ERRE K+ RK +R
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE--RKKERRKK 202
Query: 378 VDELRDRK 385
+ +DRK
Sbjct: 203 KERKKDRK 210
Score = 37.7 bits (86), Expect = 0.021
Identities = 24/79 (30%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 297 RNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQT 356
R K+E +R R ++ER+ R + E K K+ +R E +R+ KQR ++
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKK-RERGKERERKRKEREKQRKERR 90
Query: 357 EQEERREIKQRLTRKLNQR 375
E+E R+ K++ R+ QR
Sbjct: 91 EKERRKRKKEKKKRERKQR 109
Score = 36.6 bits (83), Expect = 0.047
Identities = 33/156 (21%), Positives = 61/156 (39%)
Query: 285 RKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELE 344
R+ +KE + + K++ +R R +ER++ R++ K ++ + E +
Sbjct: 48 REREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERK 107
Query: 345 RRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDR 404
+R +++ + +E RE KQR RK +R ++RK K + +
Sbjct: 108 QRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEE 167
Query: 405 RADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSK 440
R K K RKE E K + K
Sbjct: 168 REKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Score = 34.3 bits (77), Expect = 0.24
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 288 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRN 347
KKE + R R ++E + + +++E ++ E K +R QR E ERR
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRK 96
Query: 348 ILKQRND-QTEQEERREIKQRLTRKLNQRPTVDELRDRK 385
K++ + +Q RRE K++ RK +R + R+RK
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKEREREN-KQRRERK 134
Score = 33.5 bits (75), Expect = 0.40
Identities = 33/168 (19%), Positives = 76/168 (45%), Gaps = 4/168 (2%)
Query: 281 GTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAV 340
G +K +K+ K R R K+ + R R ++ER++ +++ + + K+ +R
Sbjct: 59 GKKEKKKRKKRERGKERERKRKEREKQRK---ERREKERRKRKKEKKKRERKQRGRRERK 115
Query: 341 EELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQ 400
++ ER+ ++ N Q + +R++ +++ RK +R R+RK R + E + +
Sbjct: 116 KKKERKE-RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Query: 401 DYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
+ R + + K +KE + K + + + ++ RP
Sbjct: 175 NRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRP 222
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 46.6 bits (109), Expect = 5e-05
Identities = 62/260 (23%), Positives = 109/260 (41%), Gaps = 25/260 (9%)
Query: 183 IEELHRALATKHRQDSFQGRESKGSPK--KRLDVRLSRTSSVERGKEREEAWSFDGALEN 240
++ L L K R+ +E K K K D R S+ S+E G+ R+ + N
Sbjct: 10 VKTLDEILQEKKRRKE---QEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI--TIRN 64
Query: 241 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 300
++S E++ E D L + ++ + K K++ A R +
Sbjct: 65 SPYRREDSMEDR------GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHA---RVKE 115
Query: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLS--QRPAVEELERR--NILKQRNDQT 356
++E E R D+ R+E +Q ++++ S +R +E+LER+ K R Q
Sbjct: 116 KEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 175
Query: 357 EQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK-PWTRLSA 415
EQ E++E ++R + +R E+ +R DY + KA + R + P R
Sbjct: 176 EQREQKERERRAEERRKEREARREVSAHHRTMR-EDYSDKVKASHWSRSPPRPPRERFEL 234
Query: 416 ADKAAIRKELNEYKSNEMEV 435
D RK + E K E ++
Sbjct: 235 GDG---RKPVKEEKMEERDL 251
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 45.8 bits (107), Expect = 8e-05
Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 7/184 (3%)
Query: 196 QDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENL 255
++ + RE + ++ + R ER +ERE + + KR ++ E+ E
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
Query: 256 IINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRT 315
+ +L++ YQ E N I R+ +KE + R R +E + F
Sbjct: 445 KLERKLREKEAAYQ-ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDY 503
Query: 316 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 375
D++R + + L KRL R E + +R+ + E+EE EI+QRL + +
Sbjct: 504 DDDRDDPKYYRGSALQKRLRDREKEMEAD------ERDRKREKEELEEIRQRLLAEGHPD 557
Query: 376 PTVD 379
P +
Sbjct: 558 PDAE 561
Score = 45.4 bits (106), Expect = 1e-04
Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 12/167 (7%)
Query: 215 RLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEAL 274
RL ER K RE + E +R AKE++ KE L + +DD Y+ AL
Sbjct: 460 RLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS-AL 518
Query: 275 NDSIISGTLPRKCKKELLAVKLRNRPSKQELED--RNIFPRR---TDEERQEIRQQIEMK 329
+ R +KE+ A + + K+ELE+ + + D E Q + Q+ E +
Sbjct: 519 QKRL------RDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR 572
Query: 330 LSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRP 376
++ Q P EE E K+ + EE E +Q+ K RP
Sbjct: 573 RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRP 619
Score = 44.3 bits (103), Expect = 2e-04
Identities = 83/403 (20%), Positives = 154/403 (38%), Gaps = 38/403 (9%)
Query: 37 WKWRKKK---NEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRS 93
WK +KK N + + T+ E+ + R + + KG +E++ ++ S+ P S
Sbjct: 172 WKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP-----S 226
Query: 94 VQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSA 153
+S+ K + ED P+A + K +A +++ + L K
Sbjct: 227 QESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEE-DKRDLISREISKFR 285
Query: 154 DPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLD 213
D H+ L + +E R K R++ + RE + ++R
Sbjct: 286 D------------------THKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 214 VR---LSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQ- 269
R R ER +ERE D E R +E + +++ + KD +
Sbjct: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Query: 270 --DEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIE 327
D E + R+ ++E + R R ++E E R DEE R+++E
Sbjct: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
Query: 328 MKLSKR---LSQRPAVEELERRNILKQRNDQTEQEE--RREIKQRLTRKLNQRPTVDELR 382
KL ++ +R E+ R ++ + E+EE RRE+ + R D+ R
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
Query: 383 DRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKEL 425
D R S + + ++ + AD+ + + IR+ L
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
Score = 36.2 bits (82), Expect = 0.062
Identities = 31/148 (20%), Positives = 74/148 (50%), Gaps = 12/148 (8%)
Query: 284 PRKCKKELLAVKL----RNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPA 339
P K+++ A+++ R+ S++ + R+ + +E+ ++ +++ E++ +R +R
Sbjct: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER 316
Query: 340 VEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKA 399
E ERR ++R + E+E+ +E ++ R ++ T + RDR E +
Sbjct: 317 ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD--------RERDRD 368
Query: 400 QDYDRRADKPWTRLSAADKAAIRKELNE 427
+D +R +D+ R + +K+ R+ E
Sbjct: 369 RDRERSSDRNKDRSRSREKSRDRERERE 396
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/183 (22%), Positives = 86/183 (46%), Gaps = 10/183 (5%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 252
+H Q+ + + + ++R + L R ++ E +R + +E +
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 253 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 312
E L L+ + L +++E + + L R+ +K L + R +++ E R+
Sbjct: 526 ERL--QQRLRSEQQLRREQEERREQL----LKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 313 RRTDEERQE-IRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRK 371
+R +E RQ+ ++++ E +L +RL +R VE LE+ +QR + E EE R +Q+L +
Sbjct: 580 KREEERRQQRLKREQEERLEQRL-KREEVERLEQEERREQRLKREEPEEER--RQQLLKS 636
Query: 372 LNQ 374
Q
Sbjct: 637 EEQ 639
Score = 43.9 bits (102), Expect = 3e-04
Identities = 37/192 (19%), Positives = 82/192 (42%), Gaps = 9/192 (4%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKE--------REEAWSFDGALENKRTA 244
+ +++ + R + ++RL RL + R +E REE + +R
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Query: 245 AKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQE 304
++ E + L E + L + EE L + + R ++E +L+ ++E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 305 LEDRNIFPRRTDEERQ-EIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 363
+ + +E RQ ++R++ + + +RL + E LE+R + ++ EQE E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 364 IKQRLTRKLNQR 375
+++ ++ R
Sbjct: 689 EQEQARERIKSR 700
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/252 (19%), Positives = 108/252 (42%), Gaps = 35/252 (13%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 243
E+L R K R+ + + + ++ + +L R +R +ERE + + L+ ++
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQ 303
+ +E++ S+LK ++ ++ + + ++L +LR+R S+Q
Sbjct: 1211 KQRYRDEDQR-----SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 304 ELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 363
+L+ E+++ R+Q + +R P E+LER EE++E
Sbjct: 1266 DLQ------HLLGEQQERDREQERRRWQQRDRHFPEEEQLER-------------EEQKE 1306
Query: 364 IKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRK 423
K+R + ++ + E R+ K + Q+ DR+ + L ++ +R+
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEK-----------RRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 424 ELNEYKSNEMEV 435
+ + K E E+
Sbjct: 1356 QERDRKFREEEL 1367
Score = 41.2 bits (95), Expect = 0.002
Identities = 47/243 (19%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 252
+ +Q+ + +E + + R + R + R +E E E + +E E +
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERR-------EQQLRREQEEERRE 374
Query: 253 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 312
+ L +L+ + L ++++ + ++ ++E + + +Q+L
Sbjct: 375 QQLRREQQLRREQQLRREQQLRRE--------QQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 313 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 372
R +EER E + + E R QR E+ ERR+ LK R ++TE+ E+ KQ+L
Sbjct: 427 REQEEERHEQKHEQE-----RREQRLKREQEERRDWLK-REEETERHEQERRKQQL---- 476
Query: 373 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 432
+R +E R+R + + + E + ++ R ++ R + + L + +E
Sbjct: 477 -KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 433 MEV 435
++
Sbjct: 536 QQL 538
Score = 40.4 bits (93), Expect = 0.003
Identities = 43/222 (19%), Positives = 98/222 (44%), Gaps = 16/222 (7%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKE----------REEAWS 233
EE + +Q+ + ++ + ++R + +L R ER ++ RE+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 234 FDGALENKRTAAKESEENKEN-LIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELL 292
+ L ++ +E + +E L +L+ + L ++++ + + + ++
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 293 AVKLRNRPSKQELEDRNIFPRRTDE----ERQEIRQQIEMKLSKRLSQR-PAVEELERRN 347
+ R + K+E E+R + +R +E E++ +QQ++ + +R +EE ERR
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 348 ILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIR 389
++R Q +E+ +QRL R+ + LR + L R
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Score = 40.4 bits (93), Expect = 0.003
Identities = 49/210 (23%), Positives = 88/210 (41%), Gaps = 15/210 (7%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 243
EE + L Q+ + ++ + ++R + RL R ER ++R + + E +
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE-- 684
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKC----KKELLAVKLRNR 299
A+E +E I + K L + +A + S PRK +++ K R R
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR--PRKQEGQRRRQEQEEKRRRR 742
Query: 300 PSKQELEDRNIFPRRTDEERQEI----RQQIEMKLSK---RLSQRPAVEELERRNILKQR 352
S+ + ++ R+ EE Q + Q E K + RLS RP + E R + +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 353 NDQTEQEERREIKQRLTRKLNQRPTVDELR 382
Q EQ E +++ R+ +R EL+
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Score = 40.4 bits (93), Expect = 0.003
Identities = 50/242 (20%), Positives = 92/242 (38%), Gaps = 31/242 (12%)
Query: 200 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSF-----DGALENKRTAAKESEENKEN 254
Q RE K ++ L + ER K R + W D + + +E E +
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043
Query: 255 LIINSELKDDLLLYQDEEAL----NDSIISGTLPRKCKKELLAVK-----LRNRPSKQEL 305
+ +++ L Q+EE L ++ L R+ +KE + LR P K+
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 306 EDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIK 365
++R R +E +QE Q + + KR Q + E + ++ +E + +
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 366 QRLTRKLNQRPTVD--------ELRDRKILIRFSDYVEVAKAQ---------DYDRRADK 408
Q L R+ + + E ++++ R Y E + Q D D+R+D
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 409 PW 410
W
Sbjct: 1224 KW 1225
Score = 40.0 bits (92), Expect = 0.004
Identities = 50/258 (19%), Positives = 109/258 (42%), Gaps = 35/258 (13%)
Query: 195 RQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKEN 254
R++ + + K ++RL+ RL R VER ++ E +R +E EE +
Sbjct: 581 REEERRQQRLKREQEERLEQRLKR-EEVERLEQEER--------REQRLKREEPEEERRQ 631
Query: 255 LIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRR 314
++ SE +++ Q + L R+ ++E L +L K+E E+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERR-EQRLKREEEEERLEQRL-----KREHEEERREQEL 685
Query: 315 TDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQ 374
+EE+++ R++I+ ++ K Q + + + + + Q Q R+E +++ R+ ++
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 375 RPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKA-------AIRKELNE 427
+E R + + Q+ ++R D W + A +K+ + R L E
Sbjct: 746 LQWQEEERAHR------------QQQEEEQRRDFTW-QWQAEEKSERGRQRLSARPPLRE 792
Query: 428 YKSNEMEVHASSKHLTRF 445
+ ++ + RF
Sbjct: 793 QRERQLRAEERQQREQRF 810
Score = 39.7 bits (91), Expect = 0.006
Identities = 47/211 (22%), Positives = 97/211 (45%), Gaps = 35/211 (16%)
Query: 184 EELHRALATKHRQDSFQGRESKGSP-----KKRLDVRLSRTSSVERGKEREEAWSFDGAL 238
+E A + + S +G E++ P ++R + L R E+ ++R E
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE-------- 232
Query: 239 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 298
++ + EE KE K + +L ++EE L + + ++E L
Sbjct: 233 --RQDRVFQEEEEKE------WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL------ 278
Query: 299 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 358
++LE + + R +EE+Q+ R + E +L ++ + ++ ERR ++R Q E+
Sbjct: 279 ----RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 359 EE---RREIKQRLTRKLNQRPTVDELRDRKI 386
E RRE ++R ++L +R +E R++++
Sbjct: 335 REQQLRREQEERREQQL-RREQEEERREQQL 364
Score = 39.3 bits (90), Expect = 0.007
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 18/196 (9%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGAL----E 239
++L R + Q + ++ + + R + +L R ER +++ E + L E
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 240 NKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNR 299
+R K EE + + K L Q+EE + R+ ++E +LR
Sbjct: 453 ERRDWLKREEETERHE--QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-- 508
Query: 300 PSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQE 359
+E E+R + EE + ++Q++ + R Q E R +LK+ ++ ++
Sbjct: 509 ---REQEERREQRLKRQEEEERLQQRLRSEQQLRREQ-----EERREQLLKREEEKRLEQ 560
Query: 360 ERREIKQRLTRKLNQR 375
ERRE QRL R+ +R
Sbjct: 561 ERRE--QRLKREQEER 574
Score = 38.9 bits (89), Expect = 0.010
Identities = 42/181 (23%), Positives = 78/181 (43%), Gaps = 25/181 (13%)
Query: 289 KELLAVKLRNRPSKQELEDRNIFPRRTDEE----RQEIRQQIEMKLSKRLSQRPAVEELE 344
KE L R ++ E R+ R+ +EE R++ RQ+ E +L++ Q E LE
Sbjct: 106 KESLLQDRRQEEDQRRFEPRD---RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLE 162
Query: 345 RRN-------ILKQRNDQTEQEERREIKQRLT----RKLNQRPTVDELRDRKILI----- 388
+R+ + +QR + E+EERR +++L + + P ++LR R++L
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 389 RFSDYVEVAKAQD--YDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFH 446
R + + QD + +K W + + K E + E+ + L +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 447 R 447
R
Sbjct: 283 R 283
Score = 38.9 bits (89), Expect = 0.010
Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 21/224 (9%)
Query: 224 RGKEREEAWSFDGALENKRTAA-KESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 282
R +E+E + + L+ + +E E + + + D L Q EE L G
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-----LGE 976
Query: 283 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEE 342
P K +++ K R Q+ E++ + R RQE +Q K + + + E
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 343 LERRNILKQRNDQTEQE------------ERREIKQRLTRKLNQRPTVDELRDRKILIRF 390
+ L++R Q +E E RE ++R + R + ++ + L+R
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR- 1095
Query: 391 SDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEME 434
+ E + Q+ +R+ + L ++ +R+E + + E+E
Sbjct: 1096 -EEPEKRRRQERERQC-REEEELQQEEEQLLREEREKRRRQELE 1137
Score = 38.5 bits (88), Expect = 0.012
Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 41/217 (18%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 243
EE H KH Q+ + R + ++R ++ + + R++ D E +
Sbjct: 431 EERHEQ---KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQ 303
K EE + E ++ L + EE L R+ ++E L +LR S+Q
Sbjct: 488 WLKLEEEERRE---QQERREQQLRREQEERREQR-----LKRQEEEERLQQRLR---SEQ 536
Query: 304 ELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERR----------NILKQRN 353
+L RR EER+E Q ++ + KRL Q E E+R +LK+
Sbjct: 537 QL-------RREQEERRE--QLLKREEEKRLEQ----ERREQRLKREQEERRDQLLKREE 583
Query: 354 DQTEQEERRE----IKQRLTRKLNQRPTVDELRDRKI 386
++ +Q +RE ++QRL R+ +R +E R++++
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Score = 38.1 bits (87), Expect = 0.016
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 12/196 (6%)
Query: 200 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAW--SFDGALENKRTAAKESEENKENL-- 255
+GRE K ++ R+ + + ++RE + E + +E +E +E L
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 256 IINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQEL-----EDRNI 310
+ EL+ + Q+EE + R+ ++E + R +QE E R
Sbjct: 281 LERQELRRER---QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 311 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTR 370
RR EER+E + + E + +R Q +E ERR +R Q +E++ +Q+L R
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Query: 371 KLNQRPTVDELRDRKI 386
+ R R++++
Sbjct: 398 EQQLRREQQLRREQQL 413
Score = 37.7 bits (86), Expect = 0.021
Identities = 48/206 (23%), Positives = 94/206 (45%), Gaps = 24/206 (11%)
Query: 184 EELHRALATKHRQDSFQGRES-KGSPKKRLDVRLSRTSSVERGKE--REEAWSFDGALEN 240
++L R + R+ + + + + R + +L R + R ++ RE+ + L
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 241 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 300
++ +E EE + E ++ L + EE + L R+ + E + R +
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRD------WLKREEETERHEQERRKQQ 475
Query: 301 SK--QELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 358
K QE E R + + +EER+E +++ E +L + E+ ERR +QR + E+
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRR--------EQEERR---EQRLKRQEE 524
Query: 359 EERREIKQRLTRKLNQRPTVDELRDR 384
EER ++QRL + R +E R++
Sbjct: 525 EER--LQQRLRSEQQLRREQEERREQ 548
Score = 37.0 bits (84), Expect = 0.036
Identities = 51/266 (19%), Positives = 106/266 (39%), Gaps = 36/266 (13%)
Query: 180 SRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALE 239
S+V + + RQ+ + R + S + + + E + R+ W +
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ---- 772
Query: 240 NKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNR 299
A ++SE ++ L L++ Q E L +E + R
Sbjct: 773 ----AEEKSERGRQRLSARPPLRE-----QRERQLR------------AEERQQREQRFL 811
Query: 300 PSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEE-----LERRNILKQRND 354
P ++E E R R ++E Q + ++ +++ +R Q E+ ERR +QR D
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 355 QTEQEERREIKQRLTRKLNQRPTVDE-LRDRKILIRFSDYVEVAKAQDYDRRAD-----K 408
Q + + E ++R L +P + E LR + L++ + + ++ RR + +
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 409 PWTRLSAADKAAIRKELNEYKSNEME 434
+L ++ +R+E + + E E
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERE 957
Score = 35.8 bits (81), Expect = 0.081
Identities = 71/409 (17%), Positives = 160/409 (39%), Gaps = 17/409 (4%)
Query: 40 RKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPP 99
R++K K +Q E++ RQ R+ ++ ++ Q+ + K + R + E
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 100 TPKSETLTSEDA----QPGSPLATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADP 155
+ E ++ + L ++ L + L++ Q Q K +
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR-QERDRKFREQ 1506
Query: 156 SLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVR 215
LR Q +HR + ++E + + Q Q R+ K +++L R
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL--R 1564
Query: 216 LSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKD-----DLLLYQD 270
R +ER+ + + ++ ++ E+++ L + D +D
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 271 EEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKL 330
E+ L + ++ ++ L + + R ++E + R+ R+ EE Q +++ E +L
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 331 SKRLSQRPAVEELE--RRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILI 388
++ R EE + RR +++ Q EQ+ RR Q L RK + + + +++ L
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRR---QELERKFREEEQLRQETEQEQLR 1741
Query: 389 RFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHA 437
R Y ++ + + ++ R D+ +E + E ++ +
Sbjct: 1742 RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Score = 35.4 bits (80), Expect = 0.11
Identities = 42/204 (20%), Positives = 89/204 (43%), Gaps = 23/204 (11%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 252
K Q+ Q R + K R + +L + + E+ + +E + LE ++ + E+
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER---YRKILEEEQLRPEREEQQL 1764
Query: 253 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 312
+ + +++ L Q+ E + S RK ++E +QE E++ + P
Sbjct: 1765 RRQERDRKFREEEQLRQERE--EQQLRSQESDRKFREE--------EQLRQEREEQQLRP 1814
Query: 313 RRTD------EERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQ 366
++ D EE+ ++ +Q + +R Q A E+ + ++ + QEE ++ +Q
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 367 RLTRKLNQ----RPTVDELRDRKI 386
RKL + R +E R R++
Sbjct: 1875 ERERKLREEHIRRQQKEEQRHRQV 1898
Score = 34.7 bits (78), Expect = 0.18
Identities = 56/278 (20%), Positives = 118/278 (42%), Gaps = 39/278 (14%)
Query: 178 PPSRVIEELH-RALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDG 236
PP R E RA + R+ F E + ++R R R ++ +E E+ +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ--RREREKELQFLEEEEQLQRRER 845
Query: 237 A--LENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAV 294
A L+ + +E +E + + + +D +Q EE RK ++ L
Sbjct: 846 AQQLQEEEDGLQEDQERRRS---QEQRRDQKWRWQLEEE-----------RKRRRHTLYA 891
Query: 295 K--LRNRPSKQEL---EDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNIL 349
K L+ + K++ E+ R E+R+ Q+ + + ++L Q E+L R
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE--EQLLREERE 949
Query: 350 KQRNDQTEQEERRE--IKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQ----DYD 403
K+R + E++ R++ ++Q+ + L + P ++R+ R + ++ + Q + +
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 404 RRADKPWTR-------LSAADKAAIRKELNEYKSNEME 434
+R + W R L ++ +R+E + + E E
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Score = 34.3 bits (77), Expect = 0.24
Identities = 44/204 (21%), Positives = 84/204 (41%), Gaps = 41/204 (20%)
Query: 181 RVIEELHRALATKHRQDSFQGRESKGSPKKRL--DVRLSRTSSVERGKEREEAWSFDGAL 238
R ++E L RQ+ + R+ + ++RL + +L R ER +++EE
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER------- 321
Query: 239 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 298
+E +E +E Q EE + R+ ++E +LR
Sbjct: 322 -------REQQERRE---------------QQEERREQQL------RREQEERREQQLR- 352
Query: 299 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 358
+++ E+R R ++E + QQ+ + R Q+ E+ RR +R Q +
Sbjct: 353 ---REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 359 EERREIKQRLTRKLNQRPTVDELR 382
E++ +Q+L R+ R +E R
Sbjct: 410 EQQLRREQQLRREQQLRREQEEER 433
Score = 31.6 bits (70), Expect = 1.5
Identities = 49/224 (21%), Positives = 92/224 (41%), Gaps = 16/224 (7%)
Query: 193 KHRQDS-FQGRESKGSPKKRLDVRLSRTSSVE----RGKEREEAWSFDGALENKRTAAKE 247
+ RQD FQ E K K+ +R E R +E +E LE + +
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 248 SEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELED 307
EE ++ + E L Q+EE + +++ + R + ++E E+
Sbjct: 291 QEEEQQQQRLRRE--QQLRRKQEEERREQQEERREQQERREQQ---EERREQQLRREQEE 345
Query: 308 RNIFPRRTDEERQEIRQQI--EMKLSKRLSQRPAVEELERRNILKQRND-QTEQEERREI 364
R R ++E + QQ+ E + +R Q ++L R L++ + EQ+ RRE
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 365 KQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 408
+ R ++L + +LR + L R + + + +RR +
Sbjct: 406 QLRREQQLRRE---QQLRREQQLRREQEEERHEQKHEQERREQR 446
Score = 31.6 bits (70), Expect = 1.5
Identities = 50/251 (19%), Positives = 106/251 (42%), Gaps = 22/251 (8%)
Query: 200 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 259
Q R+ + + + +LSR + +E E+ E +R +E ++ ++
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEEQQLRQERHRKF 1463
Query: 260 ELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSK---QELEDRNIFPRRTD 316
++ LL ++E+ L+ RK +E ++ + R K QEL + + +
Sbjct: 1464 REEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 317 EERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRP 376
EE+Q RQQ + K L + + ER +Q D+ +EE + ++R ++L+++
Sbjct: 1520 EEQQLHRQQRQRKF---LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 377 TVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 436
RDRK + + + Q+ +R+ + +L + ++ + K E E
Sbjct: 1577 -----RDRKFRLE----EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 437 ASSKHLTRFHR 447
+ + HR
Sbjct: 1628 LQEREEQQLHR 1638
Score = 29.6 bits (65), Expect = 5.8
Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 13/106 (12%)
Query: 313 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERR-NILKQRNDQTEQEE--RREIKQRLT 369
R+ EE Q++R+Q + + Q+ +ELER+ +Q +TEQE+ R+E +++
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 370 RKLNQRPTVDEL------RDRKI----LIRFSDYVEVAKAQDYDRR 405
+ RP +E RDRK +R + ++Q+ DR+
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
>gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens]
Length = 1989
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/360 (21%), Positives = 145/360 (40%), Gaps = 52/360 (14%)
Query: 65 EELIKKGLLEMMEQDAESKTCNPD------GGPRSVQSEPPTPKSETLTSEDAQPGSPLA 118
EE + LL+ + E + N D +VQ +P +TL ED
Sbjct: 222 EETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDP-----KTLNFEDQ------- 269
Query: 119 TGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLP 178
T TD VS+ K S ++ Q FQA +K LR +L+ P L V
Sbjct: 270 TSTDNVSITKDSSKEVAPEEKTQVKTFQAFELK----PLRQKLTLPGDKNRLKKVKDGAK 325
Query: 179 PSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRT---SSVERGKEREEAWSFD 235
P + + DS QG + K ++ L R+S + S + G++ EE
Sbjct: 326 PLSLKSD---------TTDSSQGLQDK---EQNLTRRISTSDILSEKKLGEDEEELSELQ 373
Query: 236 GALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVK 295
L ++A+K+ ++ ++ ++ S+ K + + + + T KK K
Sbjct: 374 LRLLALQSASKKWQQKEQQVMKESKEK-----LTKTKTVQQKVKTSTKTHSAKKVSTTAK 428
Query: 296 LRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQ 355
R KQ+ + ++ ++ERQ +++ + K ++ +R EE+ + L + +Q
Sbjct: 429 QALR--KQQTKAWKKLQQQKEQERQ--KEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQ 484
Query: 356 TEQEERREIKQRLTRKLNQRPTVDELRDRKI------LIRFSDYVEVAKAQDYDRRADKP 409
+ + +R +R + P + D++ + ++ +Y EVA D + + P
Sbjct: 485 YNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAP 544
Score = 28.9 bits (63), Expect = 9.9
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 15/208 (7%)
Query: 239 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 298
E+ +T E + + +N+ I KD EE + +++L +N
Sbjct: 259 EDPKTLNFEDQTSTDNVSIT---KDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKN 315
Query: 299 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLS------------QRPAVEELERR 346
R K + + + + + + Q E L++R+S + EL+ R
Sbjct: 316 RLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLR 375
Query: 347 NILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRA 406
+ Q + Q++ +++ + KL + TV + + V Q ++
Sbjct: 376 LLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQ 435
Query: 407 DKPWTRLSAADKAAIRKELNEYKSNEME 434
K W +L + +KE ++ K E E
Sbjct: 436 TKAWKKLQQQKEQERQKEEDQRKQAEEE 463
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 45.4 bits (106), Expect = 1e-04
Identities = 84/411 (20%), Positives = 145/411 (35%), Gaps = 69/411 (16%)
Query: 91 PRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQ-----------VSLDKPLSSAAHLDDA 139
P+ V SE P E A+P P G + KP +S+ A
Sbjct: 368 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSA 427
Query: 140 GQ--ATLFQASSMKSADPSLRGQLSTPTG----------------SPHLTTVHRPLPPSR 181
GQ A QA + S R + S P T P P S+
Sbjct: 428 GQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
Query: 182 VIEELHRALATKHRQDSFQGRES----------KGSPKKRLDVRLSRTSSVERGKEREEA 231
V+ L L T R S K + R+D + +E + +EEA
Sbjct: 488 VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEA 547
Query: 232 WSF--DGALENKRTAAKESEENKENLI------------INSELKDDL--LLYQDEEALN 275
E+KR +E + +E + + E K + Q +E
Sbjct: 548 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 607
Query: 276 DSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLS 335
+ K KK+ A K+ ++++ E+ R +E +E R Q ++ K
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 667
Query: 336 QRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVE 395
Q + E + + +QR + ++ERRE ++R + Q E R+++ E
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQ-----ERREQE-----RQLAE 717
Query: 396 VAKAQDYDR-RADKPWTRLSAA---DKAAIRKELNEYKSNEMEVHASSKHL 442
+ ++ +R +A++ A K +++EL E K E + + + L
Sbjct: 718 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
Score = 39.7 bits (91), Expect = 0.006
Identities = 56/244 (22%), Positives = 100/244 (40%), Gaps = 29/244 (11%)
Query: 184 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 243
E L + L + R + + K KK+++ + ++ + K +EE + + A K+
Sbjct: 572 ERLRKVLQARERVE-----QMKEEKKKQIEQKFAQIDE-KTEKAKEERLAEEKA--KKKA 623
Query: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQ 303
AAK+ EE + E + L Q+EE + + KKE +LR +
Sbjct: 624 AAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL-----QKKKEEEQERLRKAAEAK 678
Query: 304 ELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 363
L ++ RR E R++ R++ E + E ERR +Q EQE RRE
Sbjct: 679 RLAEQREQERREQERREQERREQERR------------EQERR---EQERQLAEQERRRE 723
Query: 364 IKQ-RLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIR 422
++ + R+L +R L+ ++ + + + Q R + A + A
Sbjct: 724 QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 783
Query: 423 KELN 426
K LN
Sbjct: 784 KALN 787
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 45.1 bits (105), Expect = 1e-04
Identities = 75/369 (20%), Positives = 144/369 (39%), Gaps = 58/369 (15%)
Query: 64 REELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTP------KSETLTSEDAQPGSPL 117
+E+ +K +E +++ K + D +++ P + KS + S+D++ S
Sbjct: 290 KEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKD 349
Query: 118 ATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSA----DPSLRGQLSTPTGSPH---- 169
G+ + SS ++ +G ++ +A+ +K+ L ++ T SP
Sbjct: 350 DKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCY 409
Query: 170 -LTTVHRPLPPSRVIEELHRALATKHRQ----DSFQGRESKGSPKKRLDVRLSRTSSVER 224
+ T+ SR I LHR H Q + +G SK KK D + S SS ++
Sbjct: 410 GIVTMSSSTEVSRCIAHLHRT--ELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDK 467
Query: 225 GKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLP 284
+ + +++ + + E E KE+ D + ++ ND+ SG
Sbjct: 468 KNTSDRSSKTQASVKKEEKRSSEKSEKKES--------KDTKKIEGKDEKNDNGASGQTS 519
Query: 285 RKCKKELLAVKLRN-----------------RPSKQ-----------ELEDRNIFPRRT- 315
KK ++ + RPS++ E E ++ +R
Sbjct: 520 ESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
Query: 316 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 375
D R+EI +MK + E L R L++R + E+E R + R+ R+ +R
Sbjct: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
Query: 376 PTVDELRDR 384
+ R+R
Sbjct: 640 ERLQRERER 648
Score = 37.0 bits (84), Expect = 0.036
Identities = 43/189 (22%), Positives = 84/189 (44%), Gaps = 32/189 (16%)
Query: 224 RGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTL 283
R KE+E A +L+ KR + + ++ ++ ++K E+ L + ++
Sbjct: 564 RSKEKERA-----SLDKKR----DKDYRRKEILPFEKMK--------EQRLREHLVRFER 606
Query: 284 PRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEEL 343
R+ + ++ R ++ R I R E Q R+++E++ K +R E L
Sbjct: 607 LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERL 666
Query: 344 ERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYV--EVAKAQD 401
ER I + EQE R+E +R+ R+ +ELR ++ +R+ + + +D
Sbjct: 667 ERERI------RIEQERRKE-AERIARER------EELRRQQQQLRYEQEKRNSLKRPRD 713
Query: 402 YDRRADKPW 410
D R D P+
Sbjct: 714 VDHRRDDPY 722
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 45.1 bits (105), Expect = 1e-04
Identities = 75/369 (20%), Positives = 144/369 (39%), Gaps = 58/369 (15%)
Query: 64 REELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTP------KSETLTSEDAQPGSPL 117
+E+ +K +E +++ K + D +++ P + KS + S+D++ S
Sbjct: 308 KEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKD 367
Query: 118 ATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSA----DPSLRGQLSTPTGSPH---- 169
G+ + SS ++ +G ++ +A+ +K+ L ++ T SP
Sbjct: 368 DKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCY 427
Query: 170 -LTTVHRPLPPSRVIEELHRALATKHRQ----DSFQGRESKGSPKKRLDVRLSRTSSVER 224
+ T+ SR I LHR H Q + +G SK KK D + S SS ++
Sbjct: 428 GIVTMSSSTEVSRCIAHLHRT--ELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDK 485
Query: 225 GKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLP 284
+ + +++ + + E E KE+ D + ++ ND+ SG
Sbjct: 486 KNTSDRSSKTQASVKKEEKRSSEKSEKKES--------KDTKKIEGKDEKNDNGASGQTS 537
Query: 285 RKCKKELLAVKLRN-----------------RPSKQ-----------ELEDRNIFPRRT- 315
KK ++ + RPS++ E E ++ +R
Sbjct: 538 ESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 597
Query: 316 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 375
D R+EI +MK + E L R L++R + E+E R + R+ R+ +R
Sbjct: 598 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 657
Query: 376 PTVDELRDR 384
+ R+R
Sbjct: 658 ERLQRERER 666
Score = 37.0 bits (84), Expect = 0.036
Identities = 43/189 (22%), Positives = 84/189 (44%), Gaps = 32/189 (16%)
Query: 224 RGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTL 283
R KE+E A +L+ KR + + ++ ++ ++K E+ L + ++
Sbjct: 582 RSKEKERA-----SLDKKR----DKDYRRKEILPFEKMK--------EQRLREHLVRFER 624
Query: 284 PRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEEL 343
R+ + ++ R ++ R I R E Q R+++E++ K +R E L
Sbjct: 625 LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERL 684
Query: 344 ERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYV--EVAKAQD 401
ER I + EQE R+E +R+ R+ +ELR ++ +R+ + + +D
Sbjct: 685 ERERI------RIEQERRKE-AERIARER------EELRRQQQQLRYEQEKRNSLKRPRD 731
Query: 402 YDRRADKPW 410
D R D P+
Sbjct: 732 VDHRRDDPY 740
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 45.1 bits (105), Expect = 1e-04
Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 11/187 (5%)
Query: 223 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 282
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 283 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 338
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 339 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 398
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 399 AQDYDRR 405
Q+Y RR
Sbjct: 464 EQEYIRR 470
Score = 37.7 bits (86), Expect = 0.021
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 223 ERGKEREEAWSFDGALENKRTAAKESEENKENLIIN----SELKDDLLLYQDE-----EA 273
+RG++ E + + G+ E + ++ E + + I+N S L+ D L Q E EA
Sbjct: 312 KRGEKDETEYEYSGSEEEEEEVPEQ--EGEPSSIVNVPGESTLRRDFLRLQQENKERSEA 369
Query: 274 LN-DSIISGTLPRK---CKKELLAVKLRN-------RPSKQELEDRNIFPRRTDEERQEI 322
L ++ R+ K++LLA + + R +E + R RR E Q
Sbjct: 370 LRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRR 429
Query: 323 RQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE-RREIKQ 366
R+Q E + + L +R EE RR ++R + EQE RR++++
Sbjct: 430 REQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 45.1 bits (105), Expect = 1e-04
Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 11/187 (5%)
Query: 223 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 282
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 283 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 338
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 339 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 398
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 399 AQDYDRR 405
Q+Y RR
Sbjct: 464 EQEYIRR 470
Score = 37.7 bits (86), Expect = 0.021
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 223 ERGKEREEAWSFDGALENKRTAAKESEENKENLIIN----SELKDDLLLYQDE-----EA 273
+RG++ E + + G+ E + ++ E + + I+N S L+ D L Q E EA
Sbjct: 312 KRGEKDETEYEYSGSEEEEEEVPEQ--EGEPSSIVNVPGESTLRRDFLRLQQENKERSEA 369
Query: 274 LN-DSIISGTLPRK---CKKELLAVKLRN-------RPSKQELEDRNIFPRRTDEERQEI 322
L ++ R+ K++LLA + + R +E + R RR E Q
Sbjct: 370 LRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRR 429
Query: 323 RQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE-RREIKQ 366
R+Q E + + L +R EE RR ++R + EQE RR++++
Sbjct: 430 REQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 44.7 bits (104), Expect = 2e-04
Identities = 95/447 (21%), Positives = 167/447 (37%), Gaps = 97/447 (21%)
Query: 26 KLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREEL----------IKKGL--- 72
+LA LG + +K +N + K+ TS AG G+E L +K+G
Sbjct: 205 RLAPLGPLNPSYKSSPTRNIEKKKATST-STSGAGDVGKEALSGGEASLVEKVKRGQRTA 263
Query: 73 --LEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETL-------TSEDAQPGSPLATGTDQ 123
L ++ + + C GG S P K+ T T++ PGSP+
Sbjct: 264 TSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPA 323
Query: 124 VS-LDKPLSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRV 182
+S D P A + S K + +L Q + P G L + +
Sbjct: 324 LSGQDMPKRKAE-----------KEKSNKEREGTLAQQAAGPQGEEAL---EKHVVDKHA 369
Query: 183 IEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKR 242
E+ A K + G+ + G+ T + E K L KR
Sbjct: 370 SEKHAAAAGGKAENSAALGKPTAGT-----------TDAGEAAK----------ILAEKR 408
Query: 243 TAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSK 302
A+ +E +E + E +D L + EE L RK ++E L +L K
Sbjct: 409 RQARLQKEQEEQERVEKEEQDRL---EREE----------LKRKAEEERL--RLEEEARK 453
Query: 303 QELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERR 362
QE E R+ EE ++ ++ E + + ++R A EEL +LK++ +Q +QE+
Sbjct: 454 QEEE------RKRQEEEKKKQEGEEKRKAGEEAKRKAEEEL----LLKEKQEQEKQEKAM 503
Query: 363 EIKQRLTRKLNQRPTVDELRDRKILI-------------RFSDYVEVAKAQDYDRRADKP 409
KQ+ + R +++R + I R + ++ + D + K
Sbjct: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
Query: 410 WTRLSAADKAAIRKELNEYKSNEMEVH 436
++ + K+ N+ME++
Sbjct: 564 DPKVGVQPAVCVEKKTKLVVPNKMEIN 590
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 44.3 bits (103), Expect = 2e-04
Identities = 89/417 (21%), Positives = 160/417 (38%), Gaps = 45/417 (10%)
Query: 40 RKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPP 99
R+ + +K +T EKK ++ EE KK L ++ E S+ + + RS + E
Sbjct: 220 RRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQE----SQVTSHNKERRSKRDEKL 275
Query: 100 TPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAGQATLFQASSMKSADPSLRG 159
KS+ + A+ + ++ +PL ++ D + SS KS
Sbjct: 276 DKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKS------- 328
Query: 160 QLSTPTGSPHLTTVHRPLPPSR----VIEELHRALATKHRQDSFQGRESKGSPKKRLDVR 215
S+ T S +PP + EEL+R ++H+ + + VR
Sbjct: 329 DRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVR 388
Query: 216 LS----------RTSSVERGKEREEAWSFDGALENKRTAAKESEENKE---NLIINSELK 262
+ R + + E + + G NK + + + + N E
Sbjct: 389 IGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFT 448
Query: 263 DDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEER-QE 321
+ + E + + TL KKEL + N + D++I ++ER ++
Sbjct: 449 ESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALN----YKFNDQDIEEIVKEKERFRK 504
Query: 322 IRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQ-TEQEERREIKQRLTRK-------LN 373
MK ++ L ++ E+L ++ KQ DQ E EER E R K +N
Sbjct: 505 APPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYIN 564
Query: 374 QRPTV-DELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAAD---KAAIRKELN 426
QR + + K L+ S ++ + + RR KP ++ D +AAI +LN
Sbjct: 565 QRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLN 621
Score = 30.4 bits (67), Expect = 3.4
Identities = 44/205 (21%), Positives = 91/205 (44%), Gaps = 34/205 (16%)
Query: 203 ESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELK 262
E KG+ KK+ + S SS ++ E + +G + + + + S + ++ + E
Sbjct: 121 EKKGTMKKQANKTASSGSS-DKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFH 179
Query: 263 DDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEI 322
D E+ + D L + +KE +QEL +R E+R+ +
Sbjct: 180 DGY----GEDLMGDEEDRARLEQMTEKE----------REQELFNRI-------EKREVL 218
Query: 323 RQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLN--QRPTVDE 380
+++ E+K K+L E+ E++ K++ ++ E+++ +I++ N +R DE
Sbjct: 219 KRRFEIK--KKLKTAKKKEKKEKK---KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDE 273
Query: 381 LRDRKILIRFSDYVEVAKAQDYDRR 405
D+K S +E KA+ R+
Sbjct: 274 KLDKK-----SQAMEELKAEREKRK 293
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/228 (23%), Positives = 97/228 (42%), Gaps = 20/228 (8%)
Query: 213 DVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEE 272
D R S+ S+E G+ R+ + N ++S E++ E D L + ++
Sbjct: 5 DDRDSKRDSLEEGELRDHRMEI--TIRNSPYRREDSMEDR------GEEDDSLAIKPPQQ 56
Query: 273 ALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSK 332
+ K K++ A R + ++E E R D+ R+E +Q ++++
Sbjct: 57 MSRKEKVHHRKDEKRKEKKHA---RVKEKEREHERRKRHREEQDKARREWERQKRREMAR 113
Query: 333 RLS--QRPAVEELERR--NILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILI 388
S +R +E+LER+ K R Q EQ E++E ++R + +R E+ +
Sbjct: 114 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 173
Query: 389 RFSDYVEVAKAQDYDRRADK-PWTRLSAADKAAIRKELNEYKSNEMEV 435
R DY + KA + R + P R D RK + E K E ++
Sbjct: 174 R-EDYSDKVKASHWSRSPPRPPRERFELGDG---RKPVKEEKMEERDL 217
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 44.3 bits (103), Expect = 2e-04
Identities = 60/291 (20%), Positives = 114/291 (39%), Gaps = 47/291 (16%)
Query: 77 EQDAESKTCNPDGGPRSVQSEP------PTPKSETLTSEDAQPGSPLATGTDQVSLDKPL 130
E E + +P+ P+ V +EP P K E T E+ P P P
Sbjct: 375 EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPA 434
Query: 131 SSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRAL 190
S+ A A + + + + ++ S T + TT P +R++ E R L
Sbjct: 435 SAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAG--TT--DPEEATRLLAEKRR-L 489
Query: 191 ATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEE 250
A + R+ + R + +++ L++ + ER REE E++R A+++ E
Sbjct: 490 AREQREKEERERREQEELERQKREELAQRVAEERTTRREE--------ESRRLEAEQARE 541
Query: 251 NKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNI 310
+E L +E + L + EEA R +Q+ E+ +
Sbjct: 542 KEEQLQRQAE---ERALREREEA------------------------ERAQRQKEEEARV 574
Query: 311 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEER 361
+ RQE + + + +RL ++ +EE+ +R + D+ ++R
Sbjct: 575 -REEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
Score = 36.6 bits (83), Expect = 0.047
Identities = 35/148 (23%), Positives = 63/148 (42%), Gaps = 11/148 (7%)
Query: 238 LENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLR 297
L KR A+E E +E + + L Q E L + R+ ++ R
Sbjct: 483 LAEKRRLAREQREKEER----ERREQEELERQKREELAQRVAEERTTRREEES------R 532
Query: 298 NRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTE 357
++Q E R+ +E R++ E ++ + EE ER ++++ Q E
Sbjct: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
Query: 358 QEERREIKQRLTRKLNQRPTVDELRDRK 385
++ER E K+RL ++ +R E D+K
Sbjct: 593 EQERLERKKRL-EEIMKRTRRTEATDKK 619
Score = 34.3 bits (77), Expect = 0.24
Identities = 24/89 (26%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 289 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 348
++ LA + R KQ ++ R + RQ + +E + KRL ++ EE R +
Sbjct: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEER-KKRLEEQRQKEERRRAAV 124
Query: 349 LKQRNDQTEQE-ERREIKQRLTRKLNQRP 376
++R + E++ ER E R T + +Q+P
Sbjct: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKP 153
Score = 28.9 bits (63), Expect = 9.9
Identities = 15/70 (21%), Positives = 40/70 (57%), Gaps = 1/70 (1%)
Query: 317 EERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRP 376
++RQ + ++ + K+L+ R V LER +Q ++ +E ++ ++++ ++ +R
Sbjct: 64 DDRQRLARERREEREKQLAAREIVW-LEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
Query: 377 TVDELRDRKI 386
V+E R +++
Sbjct: 123 AVEEKRRQRL 132
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 43.9 bits (102), Expect = 3e-04
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 39/203 (19%)
Query: 183 IEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKR 242
I E R + T R++ + RES+ ++R + R ER +ER G E K
Sbjct: 38 IREREREIET--RKEGKKERESERKKERREREKRKREREKERKRER-------GKKEKKG 88
Query: 243 TAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSK 302
KE E K+ + E+ + +K KKE R R SK
Sbjct: 89 ERKKEERERKKR--------------RREKENKEGEEKEKRKKKEKKE------RGRTSK 128
Query: 303 QELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERR 362
+ E R +E ++E R++ E K +R +R E ER+ ++R E+EE R
Sbjct: 129 EGKERE-----RKEERKREERKERERKKEEREKER---ERKERKK--RERKQVGEKEEER 178
Query: 363 EIKQRLTRKLNQRPTVDELRDRK 385
+ K+R RK +R + ++R+
Sbjct: 179 KEKERKERKKRERNRKERKKERE 201
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/193 (24%), Positives = 86/193 (44%), Gaps = 12/193 (6%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 252
K R++ + + + +KR R + ER KE E ENK KE + K
Sbjct: 61 KERREREKRKREREKERKR--ERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK 118
Query: 253 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 312
E K+ + EE + R+ KKE K R R +++ E + +
Sbjct: 119 EKKERGRTSKEGKERERKEERKREE----RKERERKKEERE-KERERKERKKRERKQVGE 173
Query: 313 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 372
+ +EER+E ++ K + +R +E ER+ +++ ++ ++EER++ +Q+ R+
Sbjct: 174 K--EEERKEKERKERKKRERNRKERK--KERERKERRERKKERKKKEERKKERQK-DRQT 228
Query: 373 NQRPTVDELRDRK 385
N R R+RK
Sbjct: 229 NWREKERGKRERK 241
Score = 36.6 bits (83), Expect = 0.047
Identities = 41/179 (22%), Positives = 72/179 (40%), Gaps = 37/179 (20%)
Query: 193 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 252
K R+ + +E + K++ + R + + GKERE E KR KE E K
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE------ERKREERKERERKK 151
Query: 253 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELE----DR 308
E E K+ +K +++ + K R K+ E +R
Sbjct: 152 EEREKERERKER--------------------KKRERKQVGEKEEERKEKERKERKKRER 191
Query: 309 NIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQR 367
N R+ + ER+E R++ + + K E + R +Q N + ++ +RE K+R
Sbjct: 192 NRKERKKERERKERRERKKERKKKE-------ERKKERQKDRQTNWREKERGKRERKER 243
Score = 33.5 bits (75), Expect = 0.40
Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 26/163 (15%)
Query: 286 KCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELER 345
K K+E + R R K++ +R ++ + ER++ R++ E K + +R E+ ER
Sbjct: 68 KRKREREKERKRERGKKEKKGER----KKEERERKKRRREKENKEGEEKEKRKKKEKKER 123
Query: 346 RNILKQRNDQTEQEER-REIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDR 404
K+ ++ +EER RE ++ RK +R E ++RK +
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERK------------------K 165
Query: 405 RADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHR 447
R K ++ ++ KE E K E K R R
Sbjct: 166 RERK---QVGEKEEERKEKERKERKKRERNRKERKKERERKER 205
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 43.5 bits (101), Expect = 4e-04
Identities = 47/205 (22%), Positives = 92/205 (44%), Gaps = 23/205 (11%)
Query: 183 IEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAW-------SFD 235
+E +AL T+H +D QGR+ G ++R + R + VER +ER++ +
Sbjct: 1590 LEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1648
Query: 236 GALENKRTAAKESEENKENLI-----INSELKDDLLLYQDEEALNDSIISGTLPRKCKKE 290
G LE + + + KE + + +++K+ ++ + I S R+ +K
Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN--RESEKR 1706
Query: 291 LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK 350
L ++ ++EL + R+ ++R E+ ++ + LS+ +EE + L+
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV---ANGNLSKAAILEE---KRQLE 1760
Query: 351 QRNDQTEQEERREIKQRLTRKLNQR 375
R Q E+E E Q + LN R
Sbjct: 1761 GRLGQLEEELEEE--QSNSELLNDR 1783
Score = 42.0 bits (97), Expect = 0.001
Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 196 QDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENL 255
++ RE G + +LS R ++ EEA + + E +R AA+E+E + L
Sbjct: 1378 EEEAAARERAGRELQTAQAQLSEW----RRRQEEEAGALEAGEEARRRAAREAEALTQRL 1433
Query: 256 IINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLA-VKLRNRPSKQELEDRNIFPRR 314
+E D L + L + T+ + +++L++ ++ + R Q L + R
Sbjct: 1434 AEKTETVD--RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR 1491
Query: 315 TDEERQEIRQQIEMKLSKRLS-QRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLN 373
EER+ + + ++ LS R EE E R L+++N + R E++ L+ K +
Sbjct: 1492 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQN----RALRAELEALLSSKDD 1547
Query: 374 QRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKEL 425
+V EL R E A A D + + L+AA+ A +R E+
Sbjct: 1548 VGKSVHELE------RACRVAEQA-ANDLRAQVTELEDELTAAEDAKLRLEV 1592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,662,786
Number of Sequences: 37866
Number of extensions: 844989
Number of successful extensions: 6420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 534
Number of HSP's that attempted gapping in prelim test: 4650
Number of HSP's gapped (non-prelim): 1534
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.