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Search of human proteins with 34147456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
(830 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 1692 0.0
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 79 2e-14
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 75 2e-13
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 69 2e-11
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 69 2e-11
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 68 4e-11
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 66 1e-10
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 66 2e-10
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 65 3e-10
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 65 3e-10
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 65 3e-10
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 65 3e-10
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 65 3e-10
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 64 8e-10
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 63 1e-09
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 63 1e-09
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 63 1e-09
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 63 1e-09
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 63 1e-09
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 62 3e-09
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 62 3e-09
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 60 6e-09
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 60 8e-09
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 60 8e-09
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 60 8e-09
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 60 1e-08
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 60 1e-08
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 60 1e-08
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 59 2e-08
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 59 2e-08
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 1692 bits (4381), Expect = 0.0
Identities = 830/830 (100%), Positives = 830/830 (100%)
Query: 1 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS 60
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS
Sbjct: 1 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS 60
Query: 61 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP 120
RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP
Sbjct: 61 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP 120
Query: 121 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP 180
KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP
Sbjct: 121 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP 180
Query: 181 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE 240
ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE
Sbjct: 181 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE 240
Query: 241 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG 300
DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG
Sbjct: 241 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG 300
Query: 301 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA 360
ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA
Sbjct: 301 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA 360
Query: 361 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE 420
ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE
Sbjct: 361 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE 420
Query: 421 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV 480
GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV
Sbjct: 421 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV 480
Query: 481 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF 540
YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF
Sbjct: 481 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF 540
Query: 541 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL 600
HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL
Sbjct: 541 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL 600
Query: 601 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS 660
QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS
Sbjct: 601 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS 660
Query: 661 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP 720
SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP
Sbjct: 661 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP 720
Query: 721 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK 780
SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK
Sbjct: 721 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK 780
Query: 781 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 830
VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
Sbjct: 781 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI 830
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 79.0 bits (193), Expect = 2e-14
Identities = 66/234 (28%), Positives = 102/234 (43%), Gaps = 11/234 (4%)
Query: 392 KKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHA--KYDA-IDKDTPIPTDRQIEVDIPR 448
+ Q+ R +P +RG W L G H KY I K++P D I DI R
Sbjct: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESP--QDSAITRDINR 612
Query: 449 ---CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYA 505
H Y + +G ++ KA+ V ++ Y QG S A L L+ E A++
Sbjct: 613 TFPAHDYFKDTGG-DGQDSLYKICKAYSVYDEEIGYCQG-QSFLAAVLLLHMPEEQ-AFS 669
Query: 506 CMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFL 565
+ + Y K N + +++ + P+L NH +I +YA WFL
Sbjct: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
Query: 566 TMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF 619
T+FT FPL+ +FH+ D LL S F + + +L+ +D LL F + F
Sbjct: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFF 783
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 75.1 bits (183), Expect = 2e-13
Identities = 75/316 (23%), Positives = 123/316 (38%), Gaps = 53/316 (16%)
Query: 355 NELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWA 414
++ +A+ P+ +REK R+ F +LL + +++ K + +P +R +TW
Sbjct: 168 SDQNASGAPPMTVREK------TRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWR 221
Query: 415 ALLGVE-------------------GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL 455
L G G I YD+ +++ T RQI +DIPR + L
Sbjct: 222 LLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPL 281
Query: 456 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYL-----------NF------- 497
P F R+L W + HP Y QG++ L PF + NF
Sbjct: 282 FQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQ 341
Query: 498 ----NNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIG 553
+ EA ++ CMS + N+ IQ+ + ++++ D ++ NH
Sbjct: 342 DMLRSIEADSFWCMSKLLDGIQDNYTFAQPG--IQKKVKALEELVSRIDEQVHNHFRRYE 399
Query: 554 FIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLL---GNSSFPFCIGVAILQQLRDRLL-A 609
+A W + PL LWDT G S F + A L + R +L
Sbjct: 400 VEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDE 459
Query: 610 NGFNECILLFSDLPEI 625
F ++L +LP I
Sbjct: 460 EDFQGLLMLLQNLPTI 475
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/323 (23%), Positives = 122/323 (37%), Gaps = 50/323 (15%)
Query: 347 NLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPP 406
+LPHS + L + + +E + +R+ F +LL ++ + + IP
Sbjct: 167 SLPHS-ATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPK 225
Query: 407 LMRGLTWAALLGVEGA-------------------IHAKYDAIDKDTPIPTDRQIEVDIP 447
+R +TW L G A I YD+ + + T RQI +DIP
Sbjct: 226 PVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIP 285
Query: 448 RCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNF---------- 497
R + L+ P+ F R+L W + HP Y QG++ L PF +
Sbjct: 286 RMSP-EALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVD 344
Query: 498 -------------NNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPE 544
N EA Y CMS + N+ IQ + + ++++ D +
Sbjct: 345 TVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPG--IQMKVKMLEELVSRIDEQ 402
Query: 545 LSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLL---GNSSFPFCIGVAILQ 601
+ HL++ +A W + PL LWDT G S F + A L
Sbjct: 403 VHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLV 462
Query: 602 QLRDRLL-ANGFNECILLFSDLP 623
+ R +L F E +L +LP
Sbjct: 463 RWRKEILEEKDFQELLLFLQNLP 485
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 68.9 bits (167), Expect = 2e-11
Identities = 69/270 (25%), Positives = 115/270 (42%), Gaps = 25/270 (9%)
Query: 404 IPPLMRGLTWAALLGVEG--AIHAKYDA-IDKDTPIPTDRQIEVDIPR---CHQYDELLS 457
+P +R W L G A+ +Y I KD+ + I DI R H Y +
Sbjct: 539 VPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSA--QESVITRDIHRTFPAHDYFKDTG 596
Query: 458 SPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYN 517
+G ++ KA+ V D+ Y QG L A L +A + K +Y+
Sbjct: 597 G-DGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCV------LVKIMYD 649
Query: 518 FFLKD----NSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFP 573
+ L+D N + +++ P+L +H +++ +YA WFLT+FT FP
Sbjct: 650 YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFP 709
Query: 574 LHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFS-DLP-----EIDI 627
L +FH+ D LL + F + +A+L+ ++ LL F + F LP E +
Sbjct: 710 LCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENA 769
Query: 628 ERCVRESINLFCWTPKSATYRQHAQPPKPS 657
R + ++ N+ T K Y + Q + S
Sbjct: 770 RRLMEQACNIKVPTKKLKKYEKEYQTMRES 799
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 67.8 bits (164), Expect = 4e-11
Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 26/274 (9%)
Query: 442 IEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN 499
IE D+ R + ++ PE G +L + + H DL Y QG+ L +P LY+ N
Sbjct: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV-IQN 433
Query: 500 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY 559
E A+ C F+ NF +++ ++ L ++ DP L + L+ +
Sbjct: 434 EVDAFWCFCGFMELVQGNF--EESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCF 491
Query: 560 AIPWFLTMFTHVFPLHKIFHLWDTLLLG--NSSFPFCIGVAILQQLRDRLLANGFNECIL 617
W L F FP + LW+ L G + + AIL RD L+ +GF +
Sbjct: 492 CFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEI 551
Query: 618 LFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPK-------------PSSDSSGGR 664
L + E+ ++ V + + T A +RQ P+ P+ S
Sbjct: 552 L-KHINELTMKLSVEDVL-----TRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSP 605
Query: 665 SSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSP 698
+++P + PP S ++ P D E+ P
Sbjct: 606 TASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILP 639
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 66.2 bits (160), Expect = 1e-10
Identities = 57/221 (25%), Positives = 101/221 (45%), Gaps = 18/221 (8%)
Query: 391 YKKNQIWKEARVDIPPLMRGLTWAALLGV--EGAIHAKY------DAIDKDTPIPTDRQI 442
++ +I K + IP +RG W + A H Y +++ K + +I
Sbjct: 493 FRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVT--EEI 550
Query: 443 EVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEAL 502
E D+ R + G A RRVL A+ +P + Y Q ++ L + L + E
Sbjct: 551 ERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLL--YTKEEE 608
Query: 503 AYACMSAFIPKYLYNFFLKDNSHVI--QEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYA 560
A+ + A + L ++F N VI Q +VF ++I H PEL+ H+N++ + + +
Sbjct: 609 AFWLLVAVCERMLPDYF---NHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASV-S 664
Query: 561 IPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ 601
+ WFLT+F + PL ++ D F +G+A+L+
Sbjct: 665 LSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLE 705
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 65.9 bits (159), Expect = 2e-10
Identities = 61/250 (24%), Positives = 109/250 (43%), Gaps = 14/250 (5%)
Query: 359 AAATLPL-IIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALL 417
A +PL ++R++++++ L+ + +D+ + K +I + IPP +RG W L
Sbjct: 70 ALEEVPLEVLRQRESKW-LDMLNNWDKWMAK---KHKKIRLRCQKGIPPSLRGRAWQYLS 125
Query: 418 GVEGAIH---AKYDAIDKDTPIPTDRQ-IEVDIPRCHQYDELLSSPEGHAK--FRRVLKA 471
G + + K+D +D P IE D+ R + E+ S GH + RVLKA
Sbjct: 126 GGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKA 185
Query: 472 WVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYL 531
+ + P+ Y Q + A L ++ E A+ C+ KYL ++ + IQ
Sbjct: 186 YTLYRPEEGYCQAQAPIAAVLL-MHMPAEQ-AFWCLVQICEKYLPGYY-SEKLEAIQLDG 242
Query: 532 TVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSF 591
+ ++ P HL+ P LY WF+ F+ P + +WD
Sbjct: 243 EILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKI 302
Query: 592 PFCIGVAILQ 601
F +G+ +L+
Sbjct: 303 IFRVGLVLLK 312
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 65.1 bits (157), Expect = 3e-10
Identities = 62/248 (25%), Positives = 95/248 (38%), Gaps = 31/248 (12%)
Query: 404 IPPLMRGLTWAALLGVEGAIHAKYDAI-------------------DKDTPIPTDRQ--- 441
+PP +RG W+ +G E I + I D + DR+
Sbjct: 485 LPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASL 544
Query: 442 --IEVDIPRCHQYDELLSSPEG---HAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLN 496
I++DI R + L +G H +L A+ PD+ Y QG+ S A L LN
Sbjct: 545 ELIKLDISRT--FPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 601
Query: 497 FNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIP 556
EA A+ + + K F + + ++ +Y F + +L H P
Sbjct: 602 LE-EADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTP 660
Query: 557 DLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECI 616
D+Y I W T+++ PL +WD F F G+ IL+ D LL F
Sbjct: 661 DIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIA 720
Query: 617 LLFSDLPE 624
+ LPE
Sbjct: 721 QFLTKLPE 728
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 65.1 bits (157), Expect = 3e-10
Identities = 63/265 (23%), Positives = 98/265 (36%), Gaps = 42/265 (15%)
Query: 392 KKNQIWKEARVDIPPLMRGLTWAALLGVEGAI---------------------------- 423
K +W + IPP +RG W+ +G E I
Sbjct: 113 KVRDLWWQG---IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVEN 169
Query: 424 -HAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEG---HAKFRRVLKAWVVSHPDL 479
A + A D++ + I++DI R + L +G H +L A+ PD+
Sbjct: 170 EDAGFSAADREASLEL---IKLDISRT--FPNLCIFQQGGPYHDMLHSILGAYTCYRPDV 224
Query: 480 VYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIA 539
Y QG+ S A L LN + A A+ S + K F + + ++ Y F
Sbjct: 225 GYVQGM-SFIAAVLILNLDT-ADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFE 282
Query: 540 FHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAI 599
+ P+L H + PD+Y I W T+++ PL +WD F F + I
Sbjct: 283 ENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGI 342
Query: 600 LQQLRDRLLANGFNECILLFSDLPE 624
L+ D L F + LPE
Sbjct: 343 LKLFEDILTKMDFIHMAQFLTRLPE 367
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 65.1 bits (157), Expect = 3e-10
Identities = 63/265 (23%), Positives = 98/265 (36%), Gaps = 42/265 (15%)
Query: 392 KKNQIWKEARVDIPPLMRGLTWAALLGVEGAI---------------------------- 423
K +W + IPP +RG W+ +G E I
Sbjct: 393 KVRDLWWQG---IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVEN 449
Query: 424 -HAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEG---HAKFRRVLKAWVVSHPDL 479
A + A D++ + I++DI R + L +G H +L A+ PD+
Sbjct: 450 EDAGFSAADREASLEL---IKLDISRT--FPNLCIFQQGGPYHDMLHSILGAYTCYRPDV 504
Query: 480 VYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIA 539
Y QG+ S A L LN + A A+ S + K F + + ++ Y F
Sbjct: 505 GYVQGM-SFIAAVLILNLDT-ADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFE 562
Query: 540 FHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAI 599
+ P+L H + PD+Y I W T+++ PL +WD F F + I
Sbjct: 563 ENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGI 622
Query: 600 LQQLRDRLLANGFNECILLFSDLPE 624
L+ D L F + LPE
Sbjct: 623 LKLFEDILTKMDFIHMAQFLTRLPE 647
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 65.1 bits (157), Expect = 3e-10
Identities = 63/265 (23%), Positives = 98/265 (36%), Gaps = 42/265 (15%)
Query: 392 KKNQIWKEARVDIPPLMRGLTWAALLGVEGAI---------------------------- 423
K +W + IPP +RG W+ +G E I
Sbjct: 393 KVRDLWWQG---IPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVEN 449
Query: 424 -HAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEG---HAKFRRVLKAWVVSHPDL 479
A + A D++ + I++DI R + L +G H +L A+ PD+
Sbjct: 450 EDAGFSAADREASLEL---IKLDISRT--FPNLCIFQQGGPYHDMLHSILGAYTCYRPDV 504
Query: 480 VYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIA 539
Y QG+ S A L LN + A A+ S + K F + + ++ Y F
Sbjct: 505 GYVQGM-SFIAAVLILNLDT-ADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFE 562
Query: 540 FHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAI 599
+ P+L H + PD+Y I W T+++ PL +WD F F + I
Sbjct: 563 ENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGI 622
Query: 600 LQQLRDRLLANGFNECILLFSDLPE 624
L+ D L F + LPE
Sbjct: 623 LKLFEDILTKMDFIHMAQFLTRLPE 647
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 64.7 bits (156), Expect = 3e-10
Identities = 54/217 (24%), Positives = 89/217 (41%), Gaps = 11/217 (5%)
Query: 391 YKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQ----IEVDI 446
YKK ++ + R IP +R W L G + P D Q I D+
Sbjct: 82 YKKVKM--QCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDL 139
Query: 447 PRCHQYDELLSSPEGHAK--FRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAY 504
R E+ SP+GH + +VLKA+ + P+ Y Q + A L EA +
Sbjct: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEA--F 197
Query: 505 ACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWF 564
C+ YL ++ + ++ VF ++ P + HL ++G P LY WF
Sbjct: 198 WCLVQICEVYLPGYY-GPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
Query: 565 LTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ 601
L +F P + +WD L + F +G+ +++
Sbjct: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 63.5 bits (153), Expect = 8e-10
Identities = 55/213 (25%), Positives = 94/213 (44%), Gaps = 14/213 (6%)
Query: 404 IPPLMRGLTWAALLGV--EGAIHAKYDAIDKDTPIPT----DRQIEVDIPRCHQYDELLS 457
IP +RG W G + A + Y + + T +IE D+ R
Sbjct: 488 IPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQ 547
Query: 458 SPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYN 517
S G + RRVL A+ +P + Y Q ++ L + L + E A+ + A + L +
Sbjct: 548 SDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLL--YAKEEEAFWLLVAVCERMLPD 605
Query: 518 FFLKDNSHVIQEYL--TVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLH 575
+F N +I + VF ++I H P+L+ H+ ++ F + ++ WFLT+F V P+
Sbjct: 606 YF---NRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIE 661
Query: 576 KIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLL 608
++ D +G+AIL D+LL
Sbjct: 662 SAVNVVDCFFYDGIKAILQLGLAILDYNLDKLL 694
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)
Query: 441 QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500
+IE D+ RC + + +P K R ++ +++ H ++ Y QG+ L AP L + ++E
Sbjct: 822 RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 879
Query: 501 ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559
ALA++C + + + NF + + + +I D EL +++ G Y
Sbjct: 880 ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 936
Query: 560 AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613
WFL F +F +W+T+ + ++ + I +A+++ RD +L N F
Sbjct: 937 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 996
Query: 614 ECILLFSDLPE 624
+ I F+++ E
Sbjct: 997 DIIKFFNEMAE 1007
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)
Query: 441 QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500
+IE D+ RC + + +P K R ++ +++ H ++ Y QG+ L AP L + ++E
Sbjct: 883 RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 940
Query: 501 ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559
ALA++C + + + NF + + + +I D EL +++ G Y
Sbjct: 941 ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 997
Query: 560 AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613
WFL F +F +W+T+ + ++ + I +A+++ RD +L N F
Sbjct: 998 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 1057
Query: 614 ECILLFSDLPE 624
+ I F+++ E
Sbjct: 1058 DIIKFFNEMAE 1068
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)
Query: 441 QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500
+IE D+ RC + + +P K R ++ +++ H ++ Y QG+ L AP L + ++E
Sbjct: 877 RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 934
Query: 501 ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559
ALA++C + + + NF + + + +I D EL +++ G Y
Sbjct: 935 ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 991
Query: 560 AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613
WFL F +F +W+T+ + ++ + I +A+++ RD +L N F
Sbjct: 992 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 1051
Query: 614 ECILLFSDLPE 624
+ I F+++ E
Sbjct: 1052 DIIKFFNEMAE 1062
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)
Query: 441 QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500
+IE D+ RC + + +P K R ++ +++ H ++ Y QG+ L AP L + ++E
Sbjct: 938 RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 995
Query: 501 ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559
ALA++C + + + NF + + + +I D EL +++ G Y
Sbjct: 996 ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 1052
Query: 560 AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613
WFL F +F +W+T+ + ++ + I +A+++ RD +L N F
Sbjct: 1053 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 1112
Query: 614 ECILLFSDLPE 624
+ I F+++ E
Sbjct: 1113 DIIKFFNEMAE 1123
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 62.8 bits (151), Expect = 1e-09
Identities = 72/302 (23%), Positives = 120/302 (39%), Gaps = 12/302 (3%)
Query: 310 SSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRE 369
S L D L+ + +NRL + ++ L + +S S+ S++A+ L E
Sbjct: 76 SQLSPDDLELLAKLEEQNRLLETDSKS----LRSVNGSRRNSGSSLVSSSSASSNLSHLE 131
Query: 370 KDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGA-IHAKYD 428
+D+ RI+ + K+ Q+ + IP R + W L + I +Y
Sbjct: 132 EDSWILWGRIV--NEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYS 189
Query: 429 AIDKDTPIPTDRQIEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVYWQGLD 486
+ K T P ++ I DI R + + G V+KA+ + ++ Y QG
Sbjct: 190 ELLKMTS-PCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSA 248
Query: 487 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS 546
+ L L E A+ + Y K + + + F MI H PEL
Sbjct: 249 FIVG--LLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELF 306
Query: 547 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR 606
H F +YA WFLT+F FPL ++D + F +G+A+LQ +
Sbjct: 307 VHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAE 366
Query: 607 LL 608
L+
Sbjct: 367 LM 368
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 61.6 bits (148), Expect = 3e-09
Identities = 71/300 (23%), Positives = 122/300 (40%), Gaps = 18/300 (6%)
Query: 308 DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNEL--SAAATLPL 365
D +L D L+ + +NRL + ++ + N NS + L S++A+ L
Sbjct: 26 DSENLSPDELELLAKLEEQNRLLEADSKSMRSM------NGSRRNSGSSLVSSSSASSNL 79
Query: 366 IIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEA-RVDIPPLMRGLTWAALLGV-EGAI 423
E+DT RI + + +K ++ KE R IP R + W L + +
Sbjct: 80 SHLEEDTWILWGRIA---NEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPV 136
Query: 424 HAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVY 481
+Y + K + P ++ I DI R + E + G V+KA+ + ++ Y
Sbjct: 137 KNQYSELLKMSS-PCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
Query: 482 WQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFH 541
QG + L L E A+ + +Y K + + + F M+
Sbjct: 196 CQGSAFIVG--LLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
Query: 542 DPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ 601
P+L+ H F +YA WFLT+F FPL ++D + F +G+A+LQ
Sbjct: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 61.6 bits (148), Expect = 3e-09
Identities = 71/300 (23%), Positives = 122/300 (40%), Gaps = 18/300 (6%)
Query: 308 DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNEL--SAAATLPL 365
D +L D L+ + +NRL + ++ + N NS + L S++A+ L
Sbjct: 26 DSENLSPDELELLAKLEEQNRLLEADSKSMRSM------NGSRRNSGSSLVSSSSASSNL 79
Query: 366 IIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEA-RVDIPPLMRGLTWAALLGV-EGAI 423
E+DT RI + + +K ++ KE R IP R + W L + +
Sbjct: 80 SHLEEDTWILWGRIA---NEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPV 136
Query: 424 HAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVY 481
+Y + K + P ++ I DI R + E + G V+KA+ + ++ Y
Sbjct: 137 KNQYSELLKMSS-PCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGY 195
Query: 482 WQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFH 541
QG + L L E A+ + +Y K + + + F M+
Sbjct: 196 CQGSAFIVG--LLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQ 253
Query: 542 DPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ 601
P+L+ H F +YA WFLT+F FPL ++D + F +G+A+LQ
Sbjct: 254 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 60.5 bits (145), Expect = 6e-09
Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 4/169 (2%)
Query: 461 GHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFL 520
G +LKA+ + ++ Y QGL S A L L+ + E A+ + +
Sbjct: 869 GQLSLYNILKAYSLLDQEVGYCQGL-SFVAGILLLHMSEEE-AFKMLKFLMFDMGLRKQY 926
Query: 521 KDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHL 580
+ + ++Q + S+++ + +L NHL E P LYA PWFLTMF FPL + +
Sbjct: 927 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV 986
Query: 581 WDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF--SDLPEIDI 627
+D + L + F + +++L + +L + E I+ F S LP + +
Sbjct: 987 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGL 1035
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 60.1 bits (144), Expect = 8e-09
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 20/216 (9%)
Query: 404 IPPLMRGLTWAALLGV--EGAIHAKY--DAIDKDTP---IPTDRQIEVDIPRCHQYDELL 456
IP MRG W L G E A H Y D ++K + T+ +IE D+ R
Sbjct: 516 IPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATE-EIERDLHRSLPEHPAF 574
Query: 457 SSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEA--LAYACMSAFIPKY 514
+ G A RRVL A+ +P++ Y Q ++ + + L EA L A +P Y
Sbjct: 575 QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDY 634
Query: 515 LYNFFLKDNSHVIQEYLT--VFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVF 572
N+ V+ + VF ++ + P+L + + ++G I + ++ WFLT+F V
Sbjct: 635 Y-------NTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTI-SLSWFLTLFLSVM 686
Query: 573 PLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLL 608
P + D F + +A+L D+LL
Sbjct: 687 PFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 722
>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1006
Score = 60.1 bits (144), Expect = 8e-09
Identities = 49/199 (24%), Positives = 88/199 (44%), Gaps = 12/199 (6%)
Query: 433 DTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPF 492
DT +I+ D+ RC + + +P + R V+ ++V H D+ Y QG+ L AP
Sbjct: 788 DTVALNLHRIDKDVQRCDR-NYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPL 846
Query: 493 LYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEI 552
L + +N+ LAY+C S + + NF N + + +I D EL +++
Sbjct: 847 L-VTLDNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQN 902
Query: 553 GFIPDLY-AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRL 607
G Y WFL F +F +W+ + + + F I +A+++ R+ +
Sbjct: 903 GDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREII 962
Query: 608 LANG--FNECILLFSDLPE 624
N F + I F++ E
Sbjct: 963 RDNNMDFTDIIKFFNERAE 981
>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1051
Score = 60.1 bits (144), Expect = 8e-09
Identities = 49/199 (24%), Positives = 88/199 (44%), Gaps = 12/199 (6%)
Query: 433 DTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPF 492
DT +I+ D+ RC + + +P + R V+ ++V H D+ Y QG+ L AP
Sbjct: 833 DTVALNLHRIDKDVQRCDR-NYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPL 891
Query: 493 LYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEI 552
L + +N+ LAY+C S + + NF N + + +I D EL +++
Sbjct: 892 L-VTLDNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQN 947
Query: 553 GFIPDLY-AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRL 607
G Y WFL F +F +W+ + + + F I +A+++ R+ +
Sbjct: 948 GDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREII 1007
Query: 608 LANG--FNECILLFSDLPE 624
N F + I F++ E
Sbjct: 1008 RDNNMDFTDIIKFFNERAE 1026
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/155 (26%), Positives = 69/155 (44%), Gaps = 13/155 (8%)
Query: 466 RRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSH 525
+RVL A+ + + Y QG + L A L + NE A M I K L + +N
Sbjct: 159 KRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLR 218
Query: 526 VIQEYLTVFSQMIAFHDPELSNHLNEI----------GFIPDL---YAIPWFLTMFTHVF 572
+ + VF ++ PELS HL+ + G+ P L + + WFLT+F
Sbjct: 219 ALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCL 278
Query: 573 PLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRL 607
P + +WD++ S + +AI +L +++
Sbjct: 279 PNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/155 (26%), Positives = 69/155 (44%), Gaps = 13/155 (8%)
Query: 466 RRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSH 525
+RVL A+ + + Y QG + L A L + NE A M I K L + +N
Sbjct: 159 KRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLR 218
Query: 526 VIQEYLTVFSQMIAFHDPELSNHLNEI----------GFIPDL---YAIPWFLTMFTHVF 572
+ + VF ++ PELS HL+ + G+ P L + + WFLT+F
Sbjct: 219 ALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCL 278
Query: 573 PLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRL 607
P + +WD++ S + +AI +L +++
Sbjct: 279 PNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/155 (26%), Positives = 69/155 (44%), Gaps = 13/155 (8%)
Query: 466 RRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSH 525
+RVL A+ + + Y QG + L A L + NE A M I K L + +N
Sbjct: 159 KRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLR 218
Query: 526 VIQEYLTVFSQMIAFHDPELSNHLNEI----------GFIPDL---YAIPWFLTMFTHVF 572
+ + VF ++ PELS HL+ + G+ P L + + WFLT+F
Sbjct: 219 ALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCL 278
Query: 573 PLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRL 607
P + +WD++ S + +AI +L +++
Sbjct: 279 PNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/179 (29%), Positives = 79/179 (44%), Gaps = 14/179 (7%)
Query: 437 PTDRQIEVDIPRCHQYDELLSSP--EGHAKFRRVLKAWVVSHPDLVYWQGLDSLCA-PFL 493
P +QIE+D+ R ++ S P EG K R VL A+ +PD+ Y QGL+ L A L
Sbjct: 705 PASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764
Query: 494 YLNFNNEALAYACM----SAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHL 549
YL + A+ C+ F+P+ Y L S V Q VF +++ P L H
Sbjct: 765 YLEQED---AFWCLVTIVEVFMPRDYYTKTLL-GSQVDQR---VFRDLMSEKLPRLHGHF 817
Query: 550 NEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLL 608
+ L WFL +F +F +WD+ L F +A+ + + +L
Sbjct: 818 EQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEIL 876
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/179 (29%), Positives = 79/179 (44%), Gaps = 14/179 (7%)
Query: 437 PTDRQIEVDIPRCHQYDELLSSP--EGHAKFRRVLKAWVVSHPDLVYWQGLDSLCA-PFL 493
P +QIE+D+ R ++ S P EG K R VL A+ +PD+ Y QGL+ L A L
Sbjct: 705 PASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764
Query: 494 YLNFNNEALAYACM----SAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHL 549
YL + A+ C+ F+P+ Y L S V Q VF +++ P L H
Sbjct: 765 YLEQED---AFWCLVTIVEVFMPRDYYTKTLL-GSQVDQR---VFRDLMSEKLPRLHGHF 817
Query: 550 NEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLL 608
+ L WFL +F +F +WD+ L F +A+ + + +L
Sbjct: 818 EQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEIL 876
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,978,020
Number of Sequences: 37866
Number of extensions: 1615049
Number of successful extensions: 4811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 281
Number of HSP's that attempted gapping in prelim test: 4322
Number of HSP's gapped (non-prelim): 599
length of query: 830
length of database: 18,247,518
effective HSP length: 111
effective length of query: 719
effective length of database: 14,044,392
effective search space: 10097917848
effective search space used: 10097917848
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.