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Search of human proteins with 32261318
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32261318 unc-5 homolog B [Homo sapiens]
(945 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32261318 unc-5 homolog B [Homo sapiens] 1946 0.0
gi|16933525 unc5C [Homo sapiens] 1209 0.0
gi|209977117 unc-5 homolog D [Homo sapiens] 1004 0.0
gi|62243567 netrin receptor Unc5h1 [Homo sapiens] 799 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 132 2e-30
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 110 5e-24
gi|147904700 semaphorin 5A [Homo sapiens] 107 7e-23
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 105 3e-22
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 105 3e-22
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 105 3e-22
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 104 4e-22
gi|4505737 complement factor properdin precursor [Homo sapiens] 103 1e-21
gi|223671861 complement factor properdin precursor [Homo sapiens] 103 1e-21
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 101 4e-21
gi|27734865 unc-5 homolog C-like [Homo sapiens] 101 4e-21
gi|134031945 SCO-spondin [Homo sapiens] 97 5e-20
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 75 2e-13
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 74 8e-13
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 72 3e-12
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 72 3e-12
gi|224994173 roundabout 1 isoform d [Homo sapiens] 71 4e-12
gi|224994171 roundabout 1 isoform c [Homo sapiens] 71 4e-12
gi|19743806 roundabout 1 isoform b [Homo sapiens] 71 4e-12
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 71 4e-12
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 71 4e-12
gi|4506569 roundabout 1 isoform a [Homo sapiens] 70 9e-12
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 69 3e-11
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 67 6e-11
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 66 2e-10
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 66 2e-10
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 1946 bits (5041), Expect = 0.0
Identities = 945/945 (100%), Positives = 945/945 (100%)
Query: 1 MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV 60
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV
Sbjct: 1 MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV 60
Query: 61 KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL 120
KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL
Sbjct: 61 KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL 120
Query: 121 FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV 180
FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV
Sbjct: 121 FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV 180
Query: 181 PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT 240
PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT
Sbjct: 181 PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT 240
Query: 241 VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP 300
VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP
Sbjct: 241 VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP 300
Query: 301 VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL
Sbjct: 301 VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
Query: 361 SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG 420
SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG
Sbjct: 361 SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG 420
Query: 421 FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL 480
FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL
Sbjct: 421 FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL 480
Query: 481 KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD 540
KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD
Sbjct: 481 KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD 540
Query: 541 PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV 600
PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV
Sbjct: 541 PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV 600
Query: 601 LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP 660
LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP
Sbjct: 601 LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP 660
Query: 661 CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT 720
CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT
Sbjct: 661 CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT 720
Query: 721 PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY 780
PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY
Sbjct: 721 PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY 780
Query: 781 HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC 840
HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC
Sbjct: 781 HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC 840
Query: 841 SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA 900
SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA
Sbjct: 841 SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA 900
Query: 901 SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC 945
SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
Sbjct: 901 SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC 945
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 1209 bits (3129), Expect = 0.0
Identities = 597/941 (63%), Positives = 717/941 (76%), Gaps = 34/941 (3%)
Query: 9 GALLLALLLCWDPRLSQAGTDSGSE------VLPDSFPSAPAEPLPYFLQEPQDAYIVKN 62
G LL L+L LS +GT S ++ LP++FPS P EPLP+FL EP++AYIVKN
Sbjct: 17 GYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKN 76
Query: 63 KPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFG 122
KPV L C+A PATQIYFKCN EWV Q DH+ E +DE +GL VREV IE+SRQQVEELFG
Sbjct: 77 KPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFG 136
Query: 123 LEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPV 182
EDYWCQCVAWSSAGTTKSR+AYVRIAYLRK F+QEPLGKEV L+ EVLLQCRPPEG+PV
Sbjct: 137 PEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPV 196
Query: 183 AEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVI 242
AEVEWLKNED+IDP +D NF +TIDHNLII+QARLSDTANYTCVAKNIVAKR+STTATVI
Sbjct: 197 AEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVI 256
Query: 243 VYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVD 302
VYVNGGWS+W EWS C++RCGRG+QKRTRTCTNPAPLNGGAFCEGQ+ QK ACTT+CPVD
Sbjct: 257 VYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVD 316
Query: 303 GAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSD 362
G WT WSKWS C TEC HWR REC AP P+NGG+DC G +L SKNCTDGLCMQ T D
Sbjct: 317 GRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQ---TAPD 373
Query: 363 PNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFH 422
S D ALY G+V+A+ V +AI + V + VYR+N RDF++DI DSS AL GGF
Sbjct: 374 --------SDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSS-ALNGGFQ 424
Query: 423 PVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKV 482
PVN K AR LL +VPPDLT++A +YRGPVYAL D +DKIPMTNSP+LDPLP+LK+
Sbjct: 425 PVNIKAAR---QDLL--AVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKI 479
Query: 483 KVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPG 542
KVY +T+G+ D ++ L P S + L L++ SL Q DP
Sbjct: 480 KVY--NTSGAVTPQDDLSEFTSKLSPQMTQS--LLENEALSLKNQSLARQ------TDPS 529
Query: 543 SSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLS 602
+ G+F LGG L +P +GVSLL+P GAIPQG+ YEMY+ +++ E+ P + +QT+L+
Sbjct: 530 CTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLT 589
Query: 603 PSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCY 662
P V+CGP G LL RPV+LTM HCA+ + DW LK QA QG WE+VV + EE TPCY
Sbjct: 590 PVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCY 649
Query: 663 CQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPV 722
+L+ ACHIL + L TY G S +++A KRL+LA+F P C+SLEYS+RVYCL+DT
Sbjct: 650 IKLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQD 709
Query: 723 ALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHI 782
ALKE+L LER GG L+EEPK L FK S HNLRLS+HD+ H+ W+SKLLAKYQEIPFYH+
Sbjct: 710 ALKEILHLERQTGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHV 769
Query: 783 WSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSA 842
WSGSQ+ LHCTFTLER SL + EL CK+CVRQVEGEGQIFQL+ T++E P G +D
Sbjct: 770 WSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTG-IDLPLLD 828
Query: 843 PGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASP 902
P +T+TT GP AF IPL IRQK+C+SLDAP +RG+DWRMLA KL++DRYLNYFATK+SP
Sbjct: 829 PANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSP 888
Query: 903 TGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDG 943
TGVILDLWEA DG+L+ LA+ LEEMG+ E +V++A +G
Sbjct: 889 TGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEG 929
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 1004 bits (2595), Expect = 0.0
Identities = 505/933 (54%), Positives = 660/933 (70%), Gaps = 14/933 (1%)
Query: 2 GARSGARGALLLALLLCWDPRLSQA-GTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV 60
G GAR L L W + A GTD+G E LP+S PSAP LP+F++EP DAYI+
Sbjct: 9 GGGGGARRWLPWLGLCFWAAGTAAARGTDNG-EALPESIPSAPGT-LPHFIEEPDDAYII 66
Query: 61 KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL 120
K+ P+ LRC+A PA QI+FKCNGEWV QN+HV++E LDE++GL+VREV I V+RQQVE+
Sbjct: 67 KSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQQVEDF 126
Query: 121 FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV 180
G EDYWCQCVAWS GT+KSR+A VRIAYLRKNF+Q+P G+EVP++ ++L CRPPEGV
Sbjct: 127 HGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGV 186
Query: 181 PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT 240
P AEVEWLKNE+ ID QD N DHNLIIRQARLSD+ NYTC+A NIVAKRRS +AT
Sbjct: 187 PAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSAT 246
Query: 241 VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP 300
V+VYVNGGWSSW EWS C+ RCGRGWQKR+RTCTNPAPLNGGAFCEG + QK CT++CP
Sbjct: 247 VVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTSLCP 306
Query: 301 VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
VDG+W WS+WS CS EC H R REC APPP+NGG+ C G +S+NCTDGLC+ +KK L
Sbjct: 307 VDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPL 366
Query: 361 SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG 420
+ +E + D ALY+GL A+ V VA+L+ +GV +YRR+ D+ D+ DSS ALTGG
Sbjct: 367 HEIKPQSIENASDIALYSGLGAAV-VAVAVLV-IGVTLYRRSQSDYGVDVIDSS-ALTGG 423
Query: 421 FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL 480
F NFKT R N LL+ ++ PDLT S Y GP+ LQD DK MT S L +PL +
Sbjct: 424 FQTFNFKTVRQGNSLLLNSAMQPDLTVSR-TYSGPI-CLQDPLDKELMTESSLFNPLSDI 481
Query: 481 KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD 540
KVKV SS G+++ A+ G T+P +H R+ Q L LP
Sbjct: 482 KVKVQSSFMVSL--GVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTR 539
Query: 541 PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV 600
+G FG LGGRL +P TGVSLL+P+GAIP+ +E+Y+ IN+ E +L S+G++ +
Sbjct: 540 TELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQ-SDGSEVL 598
Query: 601 LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP 660
LSP VTCGP +++ P LT+PHCA+VS+ W LK + QG WEEV+++++E +T
Sbjct: 599 LSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDE--STS 656
Query: 661 CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT 720
CYC L+P ACH+LLD GTY TGE + AVK+L++AVF C SL+Y+LRVYC+++T
Sbjct: 657 CYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNT 716
Query: 721 PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY 780
P A +EV+ ER GG L+EEPK L FK + +L++S+ D+P WR K QE+PF
Sbjct: 717 PCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFS 776
Query: 781 HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC 840
+W +++ LHC F+LER++ +T+L+CKIC+RQ++G QI Q+ T++ E+ ++ T
Sbjct: 777 RVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETI-TFF 835
Query: 841 SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA 900
+ ST Q GP AFKIP SIRQ+IC + D PN++G DW+MLAQK S++R L+YFAT++
Sbjct: 836 AQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQS 895
Query: 901 SPTGVILDLWEALQQDDGDLNSLASALEEMGKS 933
SP+ VIL+LWEA Q DGDL+SLA ALEE+G++
Sbjct: 896 SPSAVILNLWEARHQHDGDLDSLACALEEIGRT 928
>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
Length = 842
Score = 799 bits (2063), Expect = 0.0
Identities = 443/948 (46%), Positives = 584/948 (61%), Gaps = 109/948 (11%)
Query: 1 MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV 60
M R G ALL +L W L +G + V + P A + LP+FL EP+D YIV
Sbjct: 1 MAVRPGLWPALLGIVLAAW---LRGSGAQQSATVA-NPVPGANPDLLPHFLVEPEDVYIV 56
Query: 61 KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL 120
KNKPV L C+A PATQI+FKCNGEWV Q DHV + D ++GL EV+I VSRQQVE++
Sbjct: 57 KNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKV 116
Query: 121 FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV 180
FGLE+YWCQCVAWSS+GTTKS++AY+RIAYLRKNF+QEPL KEV L+ ++L CRPPEG+
Sbjct: 117 FGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGI 176
Query: 181 PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT 240
P AEVEWL+NED++DP+ D N +T +H+L++RQARL+DTANYTCVAKNIVA+RRS +A
Sbjct: 177 PPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAA 236
Query: 241 VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP 300
VIVYV+G WS W++WS C C W R+R C++PAP NGG C+G CT
Sbjct: 237 VIVYVDGSWSPWSKWSACGLDCTH-W--RSRECSDPAPRNGGEECQGTDLDTRNCT---- 289
Query: 301 VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
S C H T
Sbjct: 290 --------------SDLCVH--------------------------------------TA 297
Query: 361 SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG 420
S P L G A+ LV+ + V++ +VY R D+D+ DSS LT G
Sbjct: 298 SGPEDVALYV-GLIAVAVCLVLLLLVLI--------LVYCRKKEGLDSDVADSS-ILTSG 347
Query: 421 FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDS-TDKIPMTNSPLLDPLPS 479
F PV+ K ++ NP LL ++ PDL+ + Y+G + QD + K +TN LL PL
Sbjct: 348 FQPVSIKPSKADNPHLL--TIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGG 405
Query: 480 LKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPR 539
+ ++ SS T ++ + + L Y LPR
Sbjct: 406 GRHTLHHSSPT------SEAEEFVSRLSTQNY----------------------FRSLPR 437
Query: 540 DPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAEST-LPLSEGTQ 598
+ GTF LGGRL IP TG+SLL+P AIP+GK YE+YL ++K E LPL+ G Q
Sbjct: 438 GTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLA-GCQ 496
Query: 599 TVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLN 658
T+LSP V+CGP G+LL RPVIL M HC E S W +LK Q+ +G WE+V+ L EE +
Sbjct: 497 TLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPS 556
Query: 659 TPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLE 718
YCQLE AC++ +QLG + GE+ S +A KRL+L +FAP CTSLEY++RVYCL
Sbjct: 557 HLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLH 616
Query: 719 DTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIP 778
DT ALKEV++LE+ LGG L++EP+ L FKDSYHNLRLS+HD+P + W+SKLL YQEIP
Sbjct: 617 DTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIP 676
Query: 779 FYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLA-ETPAGSLD 837
FYHIW+G+Q+ LHCTFTLER S ++++L CK+ V QVEG+GQ F ++ + +T L
Sbjct: 677 FYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELL 736
Query: 838 TLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFA 897
L S G V +GP AFKIP IRQKI +SLD P RG DWR LAQKL +D +L++FA
Sbjct: 737 ALESEAG--VPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFA 794
Query: 898 TKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC 945
+K SPT +IL+LWEA +G+L+ LA+A+ +G+ + + ++ +C
Sbjct: 795 SKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC 842
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 132 bits (331), Expect = 2e-30
Identities = 76/228 (33%), Positives = 110/228 (48%), Gaps = 10/228 (4%)
Query: 130 CVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLK 189
CVA + AG + R+ EP+ + +++L C+ G P + W +
Sbjct: 4419 CVATNEAGVVE--RSMSLTLQSPPIITLEPVETVINAGGKIILNCQAT-GEPQPTITWSR 4475
Query: 190 NEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGW 249
I N L +++L I A+ DT+ + CVA+N++ VIV V+GG+
Sbjct: 4476 QGHSISWDDRVNVLS--NNSLYIADAQKEDTSEFECVARNLMGSVL-VRVPVIVQVHGGF 4532
Query: 250 SSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDGAWTEW 308
S W+ W CS CG+G QKR+R C P P NGG C+G + C CPVDG+W+EW
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEW 4592
Query: 309 SKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
S W C+ C R+R C P Q+GGR C G ++ C C
Sbjct: 4593 SLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPC 4640
Score = 115 bits (288), Expect = 2e-25
Identities = 50/113 (44%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICPVDG 303
V+G WS+W W CS CG+G Q R R C NP P GG++C+G Q C CP+ G
Sbjct: 4642 VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHG 4701
Query: 304 AWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W W+ WSACS C A R+R C P PQ GGR C G+ + S C C
Sbjct: 4702 KWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPC 4754
Score = 107 bits (267), Expect = 5e-23
Identities = 49/113 (43%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDG 303
V+G WS W+ W C+ CGRG Q RTRTC NP+ +GG CEG A + C CPV G
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHG 4644
Query: 304 AWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
AW+ W W CS C R+R C PPP GG C G + C + C
Sbjct: 4645 AWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNC 4697
Score = 106 bits (265), Expect = 9e-23
Identities = 48/113 (42%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDG 303
++G W++WA WS CS CG G ++RTR C++P P GG CEG Q C + CP G
Sbjct: 4699 IHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHG 4758
Query: 304 AWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W+ WS W CS C R R C PPP NGGR C G + C +C
Sbjct: 4759 NWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMC 4811
Score = 103 bits (258), Expect = 6e-22
Identities = 48/112 (42%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICPVDGA 304
+G WS W+ W CS C G +R RTC NP P NGG C G Q C T +CPVDG+
Sbjct: 4757 HGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGS 4816
Query: 305 WTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W W WS CS C R R C P P GGR C G C C
Sbjct: 4817 WGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQAC 4868
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/199 (30%), Positives = 92/199 (46%), Gaps = 25/199 (12%)
Query: 52 QEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQ 109
+E ++ ++ N P+EL C A PA ++ + +G + Q D V G E LR+ Q
Sbjct: 3533 EEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV--LRISTAQ 3590
Query: 110 IEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNF--DQEPLGKEVPLD 167
+E + + C+A S AG + Y+ ++ N EP V +
Sbjct: 3591 VEDTGRYT------------CLASSPAGDDD--KEYLVRVHVPPNIAGTDEPRDITVLRN 3636
Query: 168 HEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVA 227
+V L+C+ + VP + WL+N + + T +L+ L I A L DTANYTCVA
Sbjct: 3637 RQVTLECKS-DAVPPPVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTANYTCVA 3694
Query: 228 KNIVAKRRSTTATVIVYVN 246
NI K TT I+ VN
Sbjct: 3695 SNIAGK---TTREFILTVN 3710
Score = 60.5 bits (145), Expect = 7e-09
Identities = 26/57 (45%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICP 300
V+G W SW WS CS CG G + R R C +P P+ GG C G Q T C CP
Sbjct: 4813 VDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACP 4869
Score = 51.2 bits (121), Expect = 4e-06
Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 30/191 (15%)
Query: 54 PQDAYIVKNKPVELRCRAF---PATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQI 110
P+D ++ N P L C A+ PAT +FK +G + N R ++I
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFK-DGTPLESN----------------RNIRI 2624
Query: 111 EVSRQQVEELFGLEDYWCQ--CVAWSSAGTT-KSRRAYVRIAYLRKNFDQ-----EPLGK 162
+ ++ L ED + CVA + AG K V I + D P
Sbjct: 2625 LPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEV 2684
Query: 163 EVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTAN 222
++ +++ + L+C +P A + W K+ + N H L I++A++SDT
Sbjct: 2685 KIKVNNTLTLECEA-YAIPSASLSWYKDGQPLKSDDHVNIAAN-GHTLQIKEAQISDTGR 2742
Query: 223 YTCVAKNIVAK 233
YTCVA NI +
Sbjct: 2743 YTCVASNIAGE 2753
Score = 46.6 bits (109), Expect = 1e-04
Identities = 45/185 (24%), Positives = 76/185 (41%), Gaps = 20/185 (10%)
Query: 53 EPQDAYIVKNKPVELRCR--AFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQI 110
EP+D +++N+ V L C+ A P I + NGE + V L L++ +
Sbjct: 3627 EPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRI--LSGGRYLQINNADL 3684
Query: 111 EVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEV 170
+ CVA + AG K+ R ++ + N P + L+
Sbjct: 3685 GDTANYT------------CVASNIAG--KTTREFILTVNVPPNIKGGPQSLVILLNKST 3730
Query: 171 LLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNI 230
+L+C EGVP + W K+ V+ + + + L I+ A ++DT Y C+A N
Sbjct: 3731 VLECIA-EGVPTPRITWRKDGAVLAGNH-ARYSILENGFLHIQSAHVTDTGRYLCMATNA 3788
Query: 231 VAKRR 235
R
Sbjct: 3789 AGTDR 3793
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/228 (22%), Positives = 83/228 (36%), Gaps = 33/228 (14%)
Query: 23 LSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRC--RAFPATQIYFK 80
+++AG +G L P P F+QEP D + V L C + +P I ++
Sbjct: 775 INEAGRATGKITLDVGSP-------PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR 827
Query: 81 CNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQ------CVAWS 134
LD +S+ + LF L + W C A +
Sbjct: 828 ---------------RLDNMPIFSRPFSVSSISQLRTGALFIL-NLWASDKGTYICEAEN 871
Query: 135 SAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVI 194
G +S + P V ++ L C G P+ E W+KN ++
Sbjct: 872 QFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML 931
Query: 195 DPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVI 242
Q+ + D +L I + +L D YTCVA N+ TT+ V+
Sbjct: 932 --LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV 977
Score = 43.9 bits (102), Expect = 7e-04
Identities = 44/179 (24%), Positives = 81/179 (45%), Gaps = 19/179 (10%)
Query: 59 IVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQ 116
++ + PV+L C+A P I W N ++ G T L ++ I++ Q
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVI------TWYKDNRLLS--GSTSMTFLNRGQI-IDIESAQ 1982
Query: 117 VEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRP 176
+ + G+ +CVA +SAG T+ Y ++ + V +++ V L+C
Sbjct: 1983 ISDA-GIY----KCVAINSAGATEL--FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA 2035
Query: 177 PEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRR 235
G+P + WLK+ + + +L+ L + A++SDT YTCVA N +++
Sbjct: 2036 -RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ 2093
Score = 43.5 bits (101), Expect = 0.001
Identities = 50/180 (27%), Positives = 78/180 (43%), Gaps = 25/180 (13%)
Query: 59 IVKNKPVELRC--RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQ 116
+V N PV L C R PA + + +G VS + GL +G R+ + ++ Q
Sbjct: 2023 VVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSN----GLQVLSGGRI----LALTSAQ 2074
Query: 117 VEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRP 176
+ + CVA ++AG K R +R+ Y+ N E V + V L C+
Sbjct: 2075 ISDTGRYT-----CVAVNAAGE-KQRDIDLRV-YVPPNIMGEEQNVSVLISQAVELLCQS 2127
Query: 177 PEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHN---LIIRQARLSDTANYTCVAKNIVAK 233
+ +P + WLK+ + L+I N L I A++ DT YTC A N+ K
Sbjct: 2128 -DAIPPPTLTWLKDGHPLLKKPG----LSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/128 (27%), Positives = 57/128 (44%), Gaps = 14/128 (10%)
Query: 106 REVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRK---NFDQEPLGK 162
R++QI ++ + L+ CVA + AGT K + Y Y+R N P
Sbjct: 2252 RQLQISIAEKSDAALYS-------CVASNVAGTAK--KEYNLQVYIRPTITNSGSHPTEI 2302
Query: 163 EVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTAN 222
V + L+C +G+P V W+K+ + + +L H L ++ +SDT
Sbjct: 2303 IVTRGKSISLECEV-QGIPPPTVTWMKDGHPLIKAKGVE-ILDEGHILQLKNIHVSDTGR 2360
Query: 223 YTCVAKNI 230
Y CVA N+
Sbjct: 2361 YVCVAVNV 2368
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/171 (24%), Positives = 77/171 (45%), Gaps = 19/171 (11%)
Query: 65 VELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLE 124
+E A P I + NG ++++ HV E L + L +++ ++ + Q V
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHV--EILADGQMLHIKKAEVSDTGQYV------- 3129
Query: 125 DYWCQCVAWSSAGTT-KSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVA 183
C A + AG K+ V + + ++E + + + + V L C G+P
Sbjct: 3130 -----CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETI--SNPVTLTC-DATGIPPP 3181
Query: 184 EVEWLKNEDVIDPTQDTNF-LLTIDHNLIIRQARLSDTANYTCVAKNIVAK 233
+ WLKN I+ + +L+ L I +++ SD+ NYTC+A N+ K
Sbjct: 3182 TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGK 3232
Score = 42.0 bits (97), Expect = 0.003
Identities = 46/185 (24%), Positives = 82/185 (44%), Gaps = 33/185 (17%)
Query: 54 PQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIE 111
P++ ++ NK + C + PA + ++ +G+ + ++DH + L L++ QI
Sbjct: 2879 PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDH--HKFLSNGRILQILNTQIT 2936
Query: 112 VSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEP--LGKE-----V 164
+ V CVA ++AG+ K Y N P +G + V
Sbjct: 2937 DIGRYV------------CVAENTAGSAKK--------YFNLNVHVPPSVIGPKSENLTV 2976
Query: 165 PLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYT 224
+++ + L C G P ++ WLKNE I +T ++ L I +A++SD YT
Sbjct: 2977 VVNNFISLTCEV-SGFPPPDLSWLKNEQPIKLNTNT-LIVPGGRTLQIIRAKVSDGGEYT 3034
Query: 225 CVAKN 229
C+A N
Sbjct: 3035 CIAIN 3039
Score = 42.0 bits (97), Expect = 0.003
Identities = 42/179 (23%), Positives = 79/179 (44%), Gaps = 20/179 (11%)
Query: 54 PQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIE 111
PQ I+ NK L C A P +I ++ +G ++ N H L+ L ++ +
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN-HARYSILENGF-LHIQSAHVT 3776
Query: 112 VSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVL 171
+ + + C+A ++AGT + RR +++ ++ + P V ++ +
Sbjct: 3777 DTGRYL------------CMATNAAGTDR-RRIDLQV-HVPPSIAPGPTNMTVIVNVQTT 3822
Query: 172 LQCRPPEGVPVAEVEWLKNEDVIDPTQDTN-FLLTIDHNLIIRQARLSDTANYTCVAKN 229
L C G+P + W KN +++ Q+ N + L +L+I + DTA Y C N
Sbjct: 3823 LACEAT-GIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Score = 41.6 bits (96), Expect = 0.004
Identities = 49/192 (25%), Positives = 74/192 (38%), Gaps = 24/192 (12%)
Query: 47 LPYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEATGLR 104
LP Q ++ PV L C+A P + + GE +S + G D + L
Sbjct: 980 LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGS--LY 1037
Query: 105 VREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEV 164
V E S + V C A ++AG K + R DQ L ++
Sbjct: 1038 VVSPGGEESGEYV------------CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDK 1085
Query: 165 PLD------HEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLS 218
P++ EV L C + +P + W K +I P + L ++ I + R S
Sbjct: 1086 PVEISVLAGEEVTLPCEV-KSLPPPIITWAKETQLISPFSPRHTFLP-SGSMKITETRTS 1143
Query: 219 DTANYTCVAKNI 230
D+ Y CVA NI
Sbjct: 1144 DSGMYLCVATNI 1155
Score = 40.0 bits (92), Expect = 0.010
Identities = 44/199 (22%), Positives = 83/199 (41%), Gaps = 20/199 (10%)
Query: 48 PYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVRE 107
P +P + +++ N P+ L C A + E ++ N + + GL++
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQI-- 4045
Query: 108 VQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSR-RAYVRIAYLRKNFDQEPLGKEVPL 166
+ V E G CVA + AGT + + V++ + +E + + +
Sbjct: 4046 ------SRAVREDAGT----YMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYV---IAV 4092
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D + L C +G+P ++ W K+ I + + +L I + D +YTC+
Sbjct: 4093 DKPITLSCE-ADGLPPPDITWHKDGRAI--VESIRQRVLSSGSLQIAFVQPGDAGHYTCM 4149
Query: 227 AKNIVAKRRSTTATVIVYV 245
A N VA ST+ + V+V
Sbjct: 4150 AAN-VAGSSSTSTKLTVHV 4167
Score = 38.9 bits (89), Expect = 0.023
Identities = 27/102 (26%), Positives = 48/102 (47%), Gaps = 4/102 (3%)
Query: 129 QCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHE-VLLQCRPPEGVPVAEVEW 187
+C+A ++AG K + + ++ L + V + ++ V LQC G+P + W
Sbjct: 1804 RCMAANTAGDHK--KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIA-NGIPNPSITW 1860
Query: 188 LKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKN 229
LK++ ++ Q + + L I + L D YTCVA N
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Score = 38.9 bits (89), Expect = 0.023
Identities = 48/194 (24%), Positives = 79/194 (40%), Gaps = 30/194 (15%)
Query: 47 LPYFLQEPQDAYIVK--NKPVELRCRA--FPATQIYFKCNGEWVSQNDHVTQEGLDEATG 102
+P ++ P+ IV+ + PV L C A P I + N + + +D + L +
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSK 3208
Query: 103 LRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGK 162
L++ Q S C+A + G K+++ Y +L G
Sbjct: 3209 LQIARSQHSDSGNYT------------CIASNMEG--KAQKYY----FLSIQVPPSVAGA 3250
Query: 163 EVPLDHEVLLQ------CRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLI-IRQA 215
E+P D VLL C G+P ++WLK+ I + ++ + + + I A
Sbjct: 3251 EIPSDVSVLLGENVELVCNA-NGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGA 3309
Query: 216 RLSDTANYTCVAKN 229
SDT YTCVA N
Sbjct: 3310 LTSDTGKYTCVATN 3323
Score = 37.7 bits (86), Expect = 0.051
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 166 LDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTC 225
+D + ++CR G P ++ WLKN + P LL + I +A++SD A YTC
Sbjct: 3356 VDTSINIECRAT-GTPPPQINWLKNGLPL-PLSSHIRLLAAGQVIRIVRAQVSDVAVYTC 3413
Query: 226 VAKN 229
VA N
Sbjct: 3414 VASN 3417
Score = 35.8 bits (81), Expect = 0.19
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 1/51 (1%)
Query: 179 GVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKN 229
G P + WLK+ +ID LL L+I QA++S+T Y C+A N
Sbjct: 1760 GSPPPTIMWLKDGQLIDERDGFKILLN-GRKLVIAQAQVSNTGLYRCMAAN 1809
Score = 35.8 bits (81), Expect = 0.19
Identities = 40/185 (21%), Positives = 72/185 (38%), Gaps = 19/185 (10%)
Query: 54 PQDAYIVKNKPVELRC--RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIE 111
P + + + K + L C + P + + +G + + V E LDE L+++ + +
Sbjct: 2299 PTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGV--EILDEGHILQLKNIHVS 2356
Query: 112 VSRQQVEELFGLEDYWCQCVAWSSAGTT-KSRRAYVRIAYLRKNFDQEPLGKEVPLDHEV 170
+ + V CVA + AG T K V + P V + V
Sbjct: 2357 DTGRYV------------CVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSV 2404
Query: 171 LLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNI 230
L C G+P+ + W K+ + + +L+ L + Q + D YTCV +N
Sbjct: 2405 SLTCEA-SGIPLPSITWFKDGWPVSLSNSVR-ILSGGRMLRLMQTTMEDAGQYTCVVRNA 2462
Query: 231 VAKRR 235
+ R
Sbjct: 2463 AGEER 2467
Score = 35.8 bits (81), Expect = 0.19
Identities = 46/185 (24%), Positives = 69/185 (37%), Gaps = 22/185 (11%)
Query: 48 PYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRV 105
P EP D + K+ P + C A P I++ NG + L G R+
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL----------LPRGDGYRI 3946
Query: 106 -REVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEV 164
IE+ Q+ CVA ++AG+ + R + +P V
Sbjct: 3947 LSSGAIEILATQLNHAGRY-----TCVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHV 3999
Query: 165 PLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYT 224
L++ +LL C G P + W K E + T N + L I +A D Y
Sbjct: 4000 ILNNPILLPCE-ATGTPSPFITWQK-EGINVNTSGRNHAVLPSGGLQISRAVREDAGTYM 4057
Query: 225 CVAKN 229
CVA+N
Sbjct: 4058 CVAQN 4062
Score = 34.3 bits (77), Expect = 0.56
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 10/103 (9%)
Query: 130 CVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLK 189
C+A +SAGT K I + Q L V L +++C+ G+P +V+W K
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSEL--LVALGDITVMECKT-SGIPPPQVKWFK 737
Query: 190 NEDVIDPTQDTNFLLTIDHNL---IIRQARLSDTANYTCVAKN 229
+ + P+ L ID L I++ + D +YTCVA N
Sbjct: 738 GDLELRPST----FLIIDPLLGLLKIQETQDLDAGDYTCVAIN 776
Score = 33.9 bits (76), Expect = 0.74
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 19/182 (10%)
Query: 56 DAYIVKNKPVELRC--RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVS 113
D ++ N ++L C R P I + +G+ + + +D+ L + Q+ S
Sbjct: 1556 DISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALY--IDKGQYLHIPRAQVSDS 1613
Query: 114 RQQVEELFGLEDYWCQCVAWSSAGTT-KSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLL 172
C + AGT KS V + + + PL K+V + H + L
Sbjct: 1614 ATYT------------CHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661
Query: 173 QCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVA 232
+C+ G P + WLK + V D + L I A+ D Y CVA ++
Sbjct: 1662 ECK-AAGNPSPILTWLK-DGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719
Query: 233 KR 234
++
Sbjct: 1720 EK 1721
Score = 32.3 bits (72), Expect = 2.1
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 170 VLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHN--LIIRQARLSDTANYTCVA 227
+ L+C G+P+ + W K+ P ++ L ID L I +A++SD+A YTC
Sbjct: 1565 IKLECET-RGLPMPAITWYKDGQ---PIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHV 1620
Query: 228 KNIVAKRRSTTATVIVYV 245
N VA + V VYV
Sbjct: 1621 AN-VAGTAEKSFHVDVYV 1637
Score = 32.3 bits (72), Expect = 2.1
Identities = 23/102 (22%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 130 CVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLK 189
CVA ++AG + ++ F + P + ++ L C+ G+P+ ++ W
Sbjct: 4239 CVANNAAG--EDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKAT-GIPLPKLTWTF 4295
Query: 190 NEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIV 231
N ++I D+ + L+I + D+ Y C A+N V
Sbjct: 4296 NNNIIPAHFDS---VNGHSELVIERVSKEDSGTYVCTAENSV 4334
Score = 31.2 bits (69), Expect = 4.8
Identities = 39/169 (23%), Positives = 65/169 (38%), Gaps = 24/169 (14%)
Query: 65 VELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLE 124
+E R P QI + NG + + H+ A G +R V+ +VS V
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLL----AAGQVIRIVRAQVSDVAVYT----- 3412
Query: 125 DYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL--DHEVLLQCRPPEGVPV 182
CVA + AG + Y + N D +E+ + + C +G P
Sbjct: 3413 -----CVASNRAGV--DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACIT-DGTPA 3464
Query: 183 AEVEWLKNEDVIDPTQDTNFLLTIDHNLIIR--QARLSDTANYTCVAKN 229
+ WL++ P L H ++++ +A D+ YTC+A N
Sbjct: 3465 PSMAWLRDGQ---PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 110 bits (276), Expect = 5e-24
Identities = 54/146 (36%), Positives = 76/146 (52%), Gaps = 5/146 (3%)
Query: 213 RQARLSDTANYTCVAKNIVAKRRSTT-ATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTR 271
++ R D + TC+ +I + S + + +GGWS W+ WS CS CG G R R
Sbjct: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
Query: 272 TCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDGAWTEWSKWSACSTECA---HWRSRECM 327
C +P P GG C+G + AC CP+DG W+ WS WSAC+ CA R+R C
Sbjct: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCN 522
Query: 328 APPPQNGGRDCSGTLLDSKNCTDGLC 353
+P PQ GG+ C G + + + C C
Sbjct: 523 SPEPQYGGKACVGDVQERQMCNKRSC 548
Score = 91.7 bits (226), Expect = 3e-18
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 224 TCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGA 283
TC + + V + V GWS WAEW+ CS CG G Q+R R+C + G
Sbjct: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGP 418
Query: 284 FCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSG 340
+ +A + C T DG W+ WS WS+CS C R R C +P PQ GG++C G
Sbjct: 419 SIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKG 478
Query: 341 TLLDSKNCTDGLC 353
+ ++K C C
Sbjct: 479 SGRETKACQGAPC 491
Score = 60.8 bits (146), Expect = 6e-09
Identities = 25/60 (41%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICPVDG 303
++G WS W+ WS C+ C G ++RTR C +P P GG C G ++ C CPVDG
Sbjct: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 107 bits (266), Expect = 7e-23
Identities = 53/132 (40%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDG 303
VNG WS+W WS CS C RG + R R C NP P GG C G + + C + CPVDG
Sbjct: 783 VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDG 842
Query: 304 AWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
W+ WS W+ CS C + R+R C P P GG C G + C C ++
Sbjct: 843 VWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEW 902
Query: 361 SDPNSHLLEASG 372
SD + EASG
Sbjct: 903 SDWSE--CEASG 912
Score = 100 bits (250), Expect = 5e-21
Identities = 46/119 (38%), Positives = 62/119 (52%), Gaps = 11/119 (9%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT--TICPVDG 303
NGGW+ W WSPCS CG G+Q R R+C+NP P +GG C GQ ++ C +CP
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
Query: 304 AWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKT 359
WT W W C+ +C R R C G DC+G ++ ++C C + KKT
Sbjct: 655 FWTGWGPWERCTAQCGGGIQARRRIC------ENGPDCAGCNVEYQSCNTNPCPELKKT 707
Score = 93.6 bits (231), Expect = 8e-19
Identities = 43/104 (41%), Positives = 57/104 (54%), Gaps = 3/104 (2%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGA 304
V+G WS W+ W+ CS CG G RTR+C+NPAP GG C G ++ C T P +
Sbjct: 840 VDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNT-QPCPES 898
Query: 305 WTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
W+EWS WS C R+R+C+ P G CSG +S+ C
Sbjct: 899 WSEWSDWSECEASGVQVRARQCILLFPM--GSQCSGNTTESRPC 940
Score = 85.1 bits (209), Expect = 3e-16
Identities = 42/114 (36%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQK---RTRTCTNPAPLNGGAFCEGQAFQKTACTTICPV 301
V+G + W+ W+PC++ G RTR+C +PAP GG CEG + C+
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSR---- 594
Query: 302 DGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGL 352
+G WT W+ WS CST C R R C P P++GGR C G + + C + L
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHL 648
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 105 bits (261), Expect = 3e-22
Identities = 48/112 (42%), Positives = 61/112 (54%), Gaps = 4/112 (3%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDGA 304
+GGWS W+ WS CS CG G R R C +P+P G CEG+A + AC CP++G
Sbjct: 435 DGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGG 494
Query: 305 WTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W WS W CS C RSR C P PQ GG+DC G + +++ C C
Sbjct: 495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDC 546
Score = 87.4 bits (215), Expect = 6e-17
Identities = 45/117 (38%), Positives = 57/117 (48%), Gaps = 13/117 (11%)
Query: 248 GWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTA-----CTTICPVD 302
GWS W+EW+ CS CG G Q+R R+C + LN CEG + Q C D
Sbjct: 381 GWSPWSEWTSCSTSCGNGIQQRGRSCDS---LNNR--CEGSSVQTRTCHIQECDKRFKQD 435
Query: 303 GAWTEWSKWSACSTECAH---WRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQN 356
G W+ WS WS+CS C R R C +P PQ G+ C G ++K C C N
Sbjct: 436 GGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPIN 492
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/103 (36%), Positives = 47/103 (45%), Gaps = 6/103 (5%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICPVDG 303
+NGGW W+ W CS CG G QKR+R C NP P GG C G + C CP+DG
Sbjct: 491 INGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDG 550
Query: 304 AWTEWSKWSACSTECAHW--RSRECMAPPPQNGGRDCSGTLLD 344
S +C + S +C A PP G T +D
Sbjct: 551 C---LSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVD 590
Score = 36.2 bits (82), Expect = 0.15
Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 8/50 (16%)
Query: 302 DGAWTEWSKWSACSTECAH---WRSRECMAPPPQNGGRDCSGTLLDSKNC 348
D W+ WS+W++CST C + R R C + C G+ + ++ C
Sbjct: 379 DDGWSPWSEWTSCSTSCGNGIQQRGRSC-----DSLNNRCEGSSVQTRTC 423
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 105 bits (261), Expect = 3e-22
Identities = 75/228 (32%), Positives = 105/228 (46%), Gaps = 29/228 (12%)
Query: 128 CQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEW 187
C A AG T SR +R R+ +E LG E+ + P G P AE EW
Sbjct: 309 CNREACGPAGRTSSRSQSLRSTDARR---REELGDEL----QQFGFPAPQTGDPAAE-EW 360
Query: 188 LKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNG 247
V T + + R +++Y+ + ++R + + V+G
Sbjct: 361 -SPWSVCSSTCGEGWQT---------RTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHG 410
Query: 248 GWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICP---VDG 303
W W+ WS CS+ CGRG++ RTRTC P GG CEG Q C +CP VDG
Sbjct: 411 AWDEWSPWSLCSSTCGRGFRDRTRTCR--PPQFGGNPCEGPEKQTKFCNIALCPGRAVDG 468
Query: 304 AWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
W EWS WSACS C+ R+REC P GG +C G +++++C
Sbjct: 469 NWNEWSSWSACSASCSQGRQQRTRECNG--PSYGGAECQGHWVETRDC 514
Score = 93.6 bits (231), Expect = 8e-19
Identities = 44/105 (41%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query: 252 WAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC--TTICPVDGAWTEWS 309
W+ WS CS+ CG GWQ RTR C + + C G ++ C + +CPV GAW EWS
Sbjct: 360 WSPWSVCSSTCGEGWQTRTRFCVSSSY---STQCSGPLREQRLCNNSAVCPVHGAWDEWS 416
Query: 310 KWSACSTECAH-WRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
WS CS+ C +R R PPQ GG C G +K C LC
Sbjct: 417 PWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALC 461
Score = 89.7 bits (221), Expect = 1e-17
Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 4/122 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDG 303
V+G W+ W+ WS CS C +G Q+RTR C P+ GGA C+G + C CPVDG
Sbjct: 466 VDGNWNEWSSWSACSASCSQGRQQRTRECNGPS--YGGAECQGHWVETRDCFLQQCPVDG 523
Query: 304 AWTEWSKWSACSTEC-AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSD 362
W W+ W +CS C A + RE + P GG C G + + C C + + +
Sbjct: 524 KWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDE 583
Query: 363 PN 364
N
Sbjct: 584 DN 585
Score = 58.5 bits (140), Expect = 3e-08
Identities = 42/145 (28%), Positives = 53/145 (36%), Gaps = 45/145 (31%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTIC------- 299
GGW W+ W C+ CG G Q RTRTC PAP G CEG + C
Sbjct: 262 GGWKLWSLWGECTRDCGGGLQTRTRTCL-PAPGVEGGGCEGVLEEGRQCNREACGPAGRT 320
Query: 300 -------------------------------PVDGAWTEWSKWSACSTECAH-W--RSRE 325
D A EWS WS CS+ C W R+R
Sbjct: 321 SSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRF 380
Query: 326 CMAPPPQNGGRDCSGTLLDSKNCTD 350
C++ + CSG L + + C +
Sbjct: 381 CVS---SSYSTQCSGPLREQRLCNN 402
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 105 bits (261), Expect = 3e-22
Identities = 48/113 (42%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICPVDG 303
V+GGW++W WS CS C G++ R RTCTNP P NGG C G A + C CPV G
Sbjct: 852 VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRG 911
Query: 304 AWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
AW+ W+ WS CS C + R+R C +P P G C G + C C
Sbjct: 912 AWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQAC 964
Score = 92.8 bits (229), Expect = 1e-18
Identities = 43/118 (36%), Positives = 60/118 (50%), Gaps = 11/118 (9%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC--TTICPVDG 303
NG W+ W+ W+ CS CG G+Q R R+C+NPAP +GG C G++ ++ C T CPV
Sbjct: 664 NGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPI 723
Query: 304 AWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKK 358
W W WS CS+ C R R C G C G ++ K C C + ++
Sbjct: 724 FWASWGSWSKCSSNCGGGMQSRRRAC------ENGNSCLGCGVEFKTCNPEGCPEVRR 775
Score = 92.0 bits (227), Expect = 2e-18
Identities = 44/104 (42%), Positives = 56/104 (53%), Gaps = 3/104 (2%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGA 304
V G WS W WSPCS CG G +RTR+CT+PAP G C G ++ C T +G
Sbjct: 909 VRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEG- 967
Query: 305 WTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
W+ WS+WS C+ + A RSR C P G C+G S+ C
Sbjct: 968 WSPWSEWSKCTDDGAQSRSRHCEELLP--GSSACAGNSSQSRPC 1009
Score = 84.3 bits (207), Expect = 5e-16
Identities = 49/145 (33%), Positives = 69/145 (47%), Gaps = 17/145 (11%)
Query: 213 RQARLSDTANYTCVAKNIVA-KRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQK--- 268
R + L D++N + +NI A R+ T +GG+ W+ W PC + G
Sbjct: 581 RCSTLEDSSNMSLWTQNITACPVRNVTR------DGGFGPWSPWQPCEHLDGDNSGSCLC 634
Query: 269 RTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECA---HWRSRE 325
R R+C +P P GG C G A C+ +GAWT WS W+ CST C R R
Sbjct: 635 RARSCDSPRPRCGGLDCLGPAIHIANCSR----NGAWTPWSSWALCSTSCGIGFQVRQRS 690
Query: 326 CMAPPPQNGGRDCSGTLLDSKNCTD 350
C P P++GGR C G + + C +
Sbjct: 691 CSNPAPRHGGRICVGKSREERFCNE 715
Score = 59.7 bits (143), Expect = 1e-08
Identities = 30/92 (32%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 269 RTRTCTNPAPLNGGAFCEGQAFQ----KTACTTICPVDGAWTEWSKWSACSTECA---HW 321
R RT T P +G C+ A ++ T+ V G W W WS+CS +C
Sbjct: 816 RRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRV 875
Query: 322 RSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
R R C P P+NGG C G + ++C C
Sbjct: 876 RKRTCTNPEPRNGGLPCVGDAAEYQDCNPQAC 907
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 104 bits (259), Expect = 4e-22
Identities = 52/121 (42%), Positives = 66/121 (54%), Gaps = 8/121 (6%)
Query: 240 TVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TI 298
T + V+G W W+ WS CS CGRG + RTR+CT P GG CEG C +
Sbjct: 339 TALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGPETHHKPCNIAL 396
Query: 299 CPVDGAWTEWSKWSACSTECAH---WRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQ 355
CPVDG W EWS WS CS C++ RSR+C A +GG +C G +S+ C + C
Sbjct: 397 CPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTA--AAHGGSECRGPWAESRECYNPECTA 454
Query: 356 N 356
N
Sbjct: 455 N 455
Score = 97.8 bits (242), Expect = 4e-20
Identities = 48/109 (44%), Positives = 55/109 (50%), Gaps = 7/109 (6%)
Query: 248 GWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC--TTICPVDGAW 305
G W++WS CS CG+G Q RTRTC +P G C G + C T +CPV G W
Sbjct: 293 GVEEWSQWSTCSVTCGQGSQVRTRTCVSPY----GTHCSGPLRESRVCNNTALCPVHGVW 348
Query: 306 TEWSKWSACSTECAH-WRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
EWS WS CS C R+R PPQ GGR C G K C LC
Sbjct: 349 EEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALC 397
Score = 79.7 bits (195), Expect = 1e-14
Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 4/111 (3%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDG 303
V+G W W+ WS CS C G Q+R+R CT A +GG+ C G + C C +G
Sbjct: 399 VDGQWQEWSSWSQCSVTCSNGTQQRSRQCT--AAAHGGSECRGPWAESRECYNPECTANG 456
Query: 304 AWTEWSKWSACSTEC-AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W +W WS CS C W R G+ C GT + + C++ C
Sbjct: 457 QWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRC 507
Score = 50.4 bits (119), Expect = 8e-06
Identities = 24/65 (36%), Positives = 30/65 (46%), Gaps = 10/65 (15%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT--------T 297
NG W+ W WS CS C GW++R RTC + G CEG + C+
Sbjct: 455 NGQWNQWGHWSGCSKSCDGGWERRIRTC--QGAVITGQQCEGTGEEVRRCSEQRCPAPYE 512
Query: 298 ICPVD 302
ICP D
Sbjct: 513 ICPED 517
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 103 bits (256), Expect = 1e-21
Identities = 48/114 (42%), Positives = 58/114 (50%), Gaps = 12/114 (10%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT--ICPVDGA 304
GGWS W W PCS C +G + R R C +PAP GG C GQA + AC T +CP GA
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 305 WTEWSKWSACSTEC-------AHWRSRECMAPPPQN--GGRDCSGTLLDSKNCT 349
W W W+ CS C RSR+C AP P G+ C G + + CT
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
Score = 91.3 bits (225), Expect = 4e-18
Identities = 44/107 (41%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI--CPVD 302
V GGW W SPC CG G RTC +P P +GG FC G A + C T CPVD
Sbjct: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
Query: 303 GAWTEWSKWSACSTECAHWRSRECM-APPPQNGGRDCSGTLLDSKNC 348
G W W +WS C + +S C P Q+ GR C G D C
Sbjct: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Score = 74.3 bits (181), Expect = 5e-13
Identities = 39/114 (34%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 246 NGGWSSWAEWSPCSNRCGRG----WQKRTRTCTNPAPLN--GGAFCEGQAFQKTACTTI- 298
+G W++W W+PCS C G + R+R C+ P P G C G A+++ CT +
Sbjct: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
Query: 299 -CPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
CPV G W W S C C R C P PQ+GG C+G + C
Sbjct: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/112 (35%), Positives = 49/112 (43%), Gaps = 8/112 (7%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQ-AFQKTAC--TTICPVDGAW 305
WS W+ W+PCS C G Q R R C G G +Q AC CP G W
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 306 TEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC-TDGLC 353
+ W W CS C+ R R C P P+ GG C G +S+ C T +C
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVC 190
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/98 (36%), Positives = 45/98 (45%), Gaps = 14/98 (14%)
Query: 245 VNGGWSSWAEWSPCSNRCGR--------GWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT 296
V+G W SW EWSPC R + G Q R RTC G C GQ C
Sbjct: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
Query: 297 TI--CPVDGAWTEWSKWSACSTECA--HWRSRECMAPP 330
+I CP+ G+W+EWS W C C R+R+ + P
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTP 409
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 103 bits (256), Expect = 1e-21
Identities = 48/114 (42%), Positives = 58/114 (50%), Gaps = 12/114 (10%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT--ICPVDGA 304
GGWS W W PCS C +G + R R C +PAP GG C GQA + AC T +CP GA
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 305 WTEWSKWSACSTEC-------AHWRSRECMAPPPQN--GGRDCSGTLLDSKNCT 349
W W W+ CS C RSR+C AP P G+ C G + + CT
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
Score = 91.3 bits (225), Expect = 4e-18
Identities = 44/107 (41%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI--CPVD 302
V GGW W SPC CG G RTC +P P +GG FC G A + C T CPVD
Sbjct: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
Query: 303 GAWTEWSKWSACSTECAHWRSRECM-APPPQNGGRDCSGTLLDSKNC 348
G W W +WS C + +S C P Q+ GR C G D C
Sbjct: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Score = 74.3 bits (181), Expect = 5e-13
Identities = 39/114 (34%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 246 NGGWSSWAEWSPCSNRCGRG----WQKRTRTCTNPAPLN--GGAFCEGQAFQKTACTTI- 298
+G W++W W+PCS C G + R+R C+ P P G C G A+++ CT +
Sbjct: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
Query: 299 -CPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
CPV G W W S C C R C P PQ+GG C+G + C
Sbjct: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/112 (35%), Positives = 49/112 (43%), Gaps = 8/112 (7%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQ-AFQKTAC--TTICPVDGAW 305
WS W+ W+PCS C G Q R R C G G +Q AC CP G W
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 306 TEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC-TDGLC 353
+ W W CS C+ R R C P P+ GG C G +S+ C T +C
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVC 190
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/98 (36%), Positives = 45/98 (45%), Gaps = 14/98 (14%)
Query: 245 VNGGWSSWAEWSPCSNRCGR--------GWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT 296
V+G W SW EWSPC R + G Q R RTC G C GQ C
Sbjct: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
Query: 297 TI--CPVDGAWTEWSKWSACSTECA--HWRSRECMAPP 330
+I CP+ G+W+EWS W C C R+R+ + P
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTP 409
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 101 bits (251), Expect = 4e-21
Identities = 62/194 (31%), Positives = 87/194 (44%), Gaps = 22/194 (11%)
Query: 177 PEGVPVAEVEWLKNED--------VIDPTQD-----TNFLLTIDHNLIIRQARLSDTANY 223
PE P + +W ++ D DP + + LT L +R R ++ Y
Sbjct: 283 PEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVR-TRSCVSSPY 341
Query: 224 TCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGA 283
+ + + R + V+G W W WS CS CGRG + R RTC P +GG
Sbjct: 342 GTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCV--PPQHGGK 399
Query: 284 FCEGQAFQKTACT-TICPVDGAWTEWSKWSACSTECAH---WRSRECMAPPPQNGGRDCS 339
CEG Q C+ CPV+G W EW W CST CA+ RSR+C P C+
Sbjct: 400 ACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGP--AWATCT 457
Query: 340 GTLLDSKNCTDGLC 353
G L D++ C++ C
Sbjct: 458 GALTDTRECSNLEC 471
Score = 75.9 bits (185), Expect = 2e-13
Identities = 39/112 (34%), Positives = 49/112 (43%), Gaps = 5/112 (4%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPV-D 302
V G W W W PCS C G Q+R+R C+ P A C G C+ + CP D
Sbjct: 418 VEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGP--AWATCTGALTDTRECSNLECPATD 475
Query: 303 GAWTEWSKWSACSTEC-AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W W+ WS CS C W+ R M G C GT + K C++ C
Sbjct: 476 SKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRC 527
>gi|27734865 unc-5 homolog C-like [Homo sapiens]
Length = 518
Score = 101 bits (251), Expect = 4e-21
Identities = 102/388 (26%), Positives = 161/388 (41%), Gaps = 28/388 (7%)
Query: 553 GGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGL 612
GG L + TG+SLL+P GA+ G+ + L++ S P Q ++SP V CGP G
Sbjct: 112 GGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLVSPVVACGPHGA 171
Query: 613 LLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPC---YCQLEPRA 669
+P LT HCAE +H + TL + + P
Sbjct: 172 SFLKPCTLTFKHCAE-----------QPSHARTYSSNTTLLDAKVWRPLGRPGAHASRDE 220
Query: 670 CHILLDQLGTYVFTGES-YSRSAVKRLQLAVF-APALCTSLEYSLRVYCLEDTPVALKEV 727
C I L Y E+ R A K LQLAVF +P + LR+Y L +TP AL+
Sbjct: 221 CRIHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCALQWA 280
Query: 728 LELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQ 787
L E+ GG L + F + + L L + W + + Q +P HIW G
Sbjct: 281 LTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEG-WENVDDSSCQLVPHLHIWHG-- 337
Query: 788 KALHCTFTLERHSLASTE----LTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAP 843
K +F R + E LT +I V + + + + A ++ + P
Sbjct: 338 KCPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRFQASEEESWAAPP 397
Query: 844 GSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSM-DRYLNYFATKASP 902
P ++P + +++ L+ + GNDWR LA L + + + + + SP
Sbjct: 398 ----PVSQPPPCNRLPPELFEQLRMLLEPNSITGNDWRGLASHLGLCGMKIRFLSCQRSP 453
Query: 903 TGVILDLWEALQQDDGDLNSLASALEEM 930
IL+L+E +L+ L + +E +
Sbjct: 454 AAAILELFEEQNGSLQELHYLMTVMERL 481
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 97.4 bits (241), Expect = 5e-20
Identities = 48/115 (41%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQA------FQKTACTT- 297
V GGW W+EW+ CS C + R+R C P P +GGA C G+A Q+ AC +
Sbjct: 3407 VPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSY 3466
Query: 298 -ICPVDGAWTEWSKWSACSTECAH-WRSRECMAPPPQNGGRDCSGTLLDSKNCTD 350
CPVDGAW W WS C RSR C PP GGR C G S+ C +
Sbjct: 3467 ATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQE 3521
Score = 93.2 bits (230), Expect = 1e-18
Identities = 46/115 (40%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEG--QAFQKTACTTI--CPV 301
N W+SWA W PCS CG G Q+R R P P GG +C A+Q+ + CPV
Sbjct: 3946 NCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGP--GGHWCPNILTAYQERRFCNLRACPV 4003
Query: 302 DGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
G W+ WS WS C C RSR C +PP +NGG C+G ++ C C
Sbjct: 4004 PGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPC 4058
Score = 91.7 bits (226), Expect = 3e-18
Identities = 42/113 (37%), Positives = 57/113 (50%), Gaps = 9/113 (7%)
Query: 248 GWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVD-GAWT 306
GWS+W+ W+PC CG G + R R+ +NP GGA CEG + C T+C + WT
Sbjct: 2717 GWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWT 2776
Query: 307 EWSKWSACSTEC------AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W+ WS+CS C WRSR + P P G C G + C+ +C
Sbjct: 2777 PWTSWSSCSQSCLAPGGGPGWRSRSRLCPSP--GDSSCPGDATQEEPCSPPVC 2827
Score = 90.1 bits (222), Expect = 9e-18
Identities = 42/94 (44%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDGAW 305
G W W+ W PCS CG Q R+R C+ P L C G Q AC T CPVDG W
Sbjct: 1695 GAWGPWSPWGPCSRTCGPWGQGRSRRCS-PLGLLVLQNCPGPEHQSQACFTAACPVDGEW 1753
Query: 306 TEWSKWSACSTECAHWRSRECMAPPPQNGGRDCS 339
+ WS WS CS C +R+ PQNGGR C+
Sbjct: 1754 STWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCA 1787
Score = 79.3 bits (194), Expect = 2e-14
Identities = 39/101 (38%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 252 WAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC-TTICPVDGAWTEWSK 310
W+ WS CS CG G + + P PL GG+ C F+ +C CPV GAW W
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRP-PLPGGS-CPRDRFRSQSCFVQACPVAGAWAMWEA 2563
Query: 311 WSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
W CS C R R C+ PPP+NGG C G + C
Sbjct: 2564 WGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604
Score = 79.3 bits (194), Expect = 2e-14
Identities = 40/115 (34%), Positives = 53/115 (46%), Gaps = 15/115 (13%)
Query: 248 GWSSWAEWSPCSNRC-----GRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICPV 301
GW+ W WS CS C G GW+ R+R C +P G + C G A Q+ C+ +CPV
Sbjct: 2774 GWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSP----GDSSCPGDATQEEPCSPPVCPV 2829
Query: 302 DGAWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
W W+ WS CS C R R C + P G C G +++C C
Sbjct: 2830 PSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCNTQPC 2882
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/119 (31%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGA 304
V G W+ W W PCS CG G Q R R+C +P P NGGA C G + ++ C G
Sbjct: 2554 VAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGT 2613
Query: 305 WTEWSKWSACSTECAHWRSRECMAPP---PQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
E + + C C PP R CSG ++ C GL + + + L
Sbjct: 2614 DCELGRVYVSADLCQKGLVPPC--PPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCL 2670
Score = 68.6 bits (166), Expect = 3e-11
Identities = 36/98 (36%), Positives = 43/98 (43%), Gaps = 12/98 (12%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDGAW 305
GGW W WS CS CG G + RTR C P P G +CEG Q C + CPV
Sbjct: 3253 GGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPVTNCT 3312
Query: 306 T-EWSKWSACSTECAH---------WRSRE-CMAPPPQ 332
E +++S C C WR + C PP Q
Sbjct: 3313 AIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQ 3350
Score = 67.4 bits (163), Expect = 6e-11
Identities = 48/155 (30%), Positives = 63/155 (40%), Gaps = 26/155 (16%)
Query: 215 ARLSDTANYTCVA-KNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTC 273
ARL N TCV+ K R A GWS W WS CS C G ++R R
Sbjct: 2960 ARLDSCNNCTCVSGKMACTSERCPVAC-------GWSPWTLWSLCSCSCNVGIRRRFRAG 3012
Query: 274 TNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQN 333
T P GGA C+G + C ++ P G EW WS CS C +N
Sbjct: 3013 TAPPAAFGGAECQGPTMEAEFC-SLRPCPGPGGEWGPWSPCSVPCGGGY---------RN 3062
Query: 334 GGRDCSGTLLDSKNC--------TDGLCMQNKKTL 360
R S +L++ C G+C ++K+ L
Sbjct: 3063 RTRGSSRSLMEFSTCGLQPCAGPVPGMCPRDKQWL 3097
Score = 65.1 bits (157), Expect = 3e-10
Identities = 37/116 (31%), Positives = 41/116 (35%), Gaps = 16/116 (13%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTN------------PAPLNGGAFCEGQAFQKTACT 296
WS W WS CS CG R R C P P C G ++ C
Sbjct: 3186 WSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCL 3245
Query: 297 TI-CPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
C G W W WS CS C R+R C PPPQ G C G + C
Sbjct: 3246 LQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVC 3301
Score = 64.3 bits (155), Expect = 5e-10
Identities = 38/119 (31%), Positives = 50/119 (42%), Gaps = 15/119 (12%)
Query: 237 TTATVIVYVNGGWSSWAEWSPCSNRC----GRGWQKRTRTCTNPAPLNGGAFCEGQAFQK 292
+T + + GGW W+ WSPCS C W+ RTR C A G + +
Sbjct: 3871 STVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCL--ANCTMGDPLQERPCNL 3928
Query: 293 TACT--TICPVDG------AWTEWSKWSACSTECAHWRSRECMA-PPPQNGGRDCSGTL 342
+CT +CP G +WT W+ W CS C + R A PP GG C L
Sbjct: 3929 PSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNIL 3987
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/148 (29%), Positives = 56/148 (37%), Gaps = 55/148 (37%)
Query: 249 WSSWAEWSPCSNRCG-RGWQKRTRTCTN---------------PAPLN------------ 280
WS W+ WSPCS+ CG RG Q R R+ T+ P P
Sbjct: 4162 WSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRS 4221
Query: 281 ---GGAFCEGQAFQKTACT--------TICPVDGAWTEWSKWSACSTECA---------- 319
G ++ +G+ Q+ +CT T C V AWT WS WS C C
Sbjct: 4222 RTLGDSWLQGEC-QRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRAC 4280
Query: 320 -----HWRSRECMAPPPQNGGRDCSGTL 342
H RS C+ P Q + C G L
Sbjct: 4281 RAAAPHHRSPPCLGPDTQTRQQPCPGLL 4308
Score = 60.8 bits (146), Expect = 6e-09
Identities = 27/74 (36%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGA 304
V GGWS W+ WS C CG G R+R+C++P NGGA C G+ Q C + P +
Sbjct: 4003 VPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPM-PCEAG 4061
Query: 305 WTEWSKWSACSTEC 318
+ C+ C
Sbjct: 4062 CPAGMEVVTCANRC 4075
Score = 60.5 bits (145), Expect = 7e-09
Identities = 34/103 (33%), Positives = 42/103 (40%), Gaps = 20/103 (19%)
Query: 246 NGGWSSWAEWSPCSNRC-GRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP---- 300
+GG+ W+ W PCS C G G + R+R C P G C G + CP
Sbjct: 3811 DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPRQDLECPSPDCPGAEG 3870
Query: 301 --------VDGAWTEWSKWSACSTECAH-----WRSRE--CMA 328
+ G W WS WS CS C WRSR C+A
Sbjct: 3871 STVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLA 3913
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/50 (48%), Positives = 29/50 (58%), Gaps = 4/50 (8%)
Query: 295 CTTI-CPVDGAWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSG 340
CT + CPV G W WS+W+ CS C RSR C P PQ+GG C+G
Sbjct: 3400 CTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTG 3449
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/136 (29%), Positives = 48/136 (35%), Gaps = 22/136 (16%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI------CP 300
G WSSW W CS CG G Q R+R C P C G A Q C+T CP
Sbjct: 3646 GVWSSWGPWEDCSVSCGGGEQLRSRRCARPP-------CPGPARQSRTCSTQVCREAGCP 3698
Query: 301 VDGAWTEWSKWSACSTECAHWRSR-ECMAPPPQNGGRDCSGTLLDSKNC--------TDG 351
+ E C CAH + C + + G GT C T
Sbjct: 3699 AGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAW 3758
Query: 352 LCMQNKKTLSDPNSHL 367
L + T+ DP L
Sbjct: 3759 LLQELGATIGDPGQPL 3774
Score = 52.4 bits (124), Expect = 2e-06
Identities = 34/109 (31%), Positives = 42/109 (38%), Gaps = 6/109 (5%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEW 308
W+ W+ WS C CG G Q RTR C AP + C G Q CP W
Sbjct: 4256 WTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTR--QQPCPGLLEACSW 4313
Query: 309 SKWSACSTECAHWRSRECMAPPPQNGGRD--CSGTL--LDSKNCTDGLC 353
W CS C + + P D C+ T LD++ C G C
Sbjct: 4314 GPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYSGPC 4362
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/117 (29%), Positives = 45/117 (38%), Gaps = 14/117 (11%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQ-----KTACTTICPVDG 303
W WA WS CS C G Q R R+C++ AP G C G Q CT CP +
Sbjct: 2833 WGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCNTQPCTAQCPENM 2890
Query: 304 AWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
+ + C R C+ P G +C+G C GL + N L
Sbjct: 2891 LFRSAEQCHQEGGPC----PRLCLTQGP---GIECTGFCAPGCTCPPGLFLHNASCL 2940
Score = 48.5 bits (114), Expect = 3e-05
Identities = 29/112 (25%), Positives = 37/112 (33%), Gaps = 13/112 (11%)
Query: 248 GWSSWAEWSPCSNRCGRGW--QKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAW 305
GW W PC R W Q+ C C+ ++ C VD W
Sbjct: 1860 GWCVWPRQCPCLVDGARYWPGQRIKADCQL-------CICQDGRPRRCRLNPDCAVDCGW 1912
Query: 306 TEWSKWSACSTECA----HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
+ WS W+ C C W R P P GR C G ++ C C
Sbjct: 1913 SSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPC 1964
Score = 47.0 bits (110), Expect = 8e-05
Identities = 26/61 (42%), Positives = 30/61 (49%), Gaps = 5/61 (8%)
Query: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEG--QAFQKTACTTICPVD 302
V+G WS+W+ WS CS C RG R R C +P NGG C T T CP D
Sbjct: 1749 VDGEWSTWSPWSVCSEPC-RGTMTRQRQCHSPQ--NGGRTCAALPGGLHSTRQTKPCPQD 1805
Query: 303 G 303
G
Sbjct: 1806 G 1806
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/115 (25%), Positives = 39/115 (33%), Gaps = 15/115 (13%)
Query: 251 SWAEWSPCSNRCGRGWQKRTRTC----TNPAPLNGGAFCEGQAFQKTACTT-ICPVDGAW 305
SW W PCS CG G R+ +C P F C + CP + W
Sbjct: 4312 SWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLH---LDTQGCYSGPCPEECVW 4368
Query: 306 TEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDS-------KNCTDGLC 353
+ WS W+ CS + P + T LD NC++ C
Sbjct: 4369 SSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISNCSEDSC 4423
Score = 45.4 bits (106), Expect = 2e-04
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 10/60 (16%)
Query: 299 CPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQ 355
CP G W+ W W CS C RSR C PP C G S+ C+ +C +
Sbjct: 3642 CPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPP-------CPGPARQSRTCSTQVCRE 3694
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/142 (31%), Positives = 57/142 (40%), Gaps = 22/142 (15%)
Query: 214 QARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTC 273
QA D N TCV +++V + V G WS+W S CS CG G +R RTC
Sbjct: 4740 QAVQLDCQNCTCVNESLVCPHQECP------VLGPWSAW---SSCSAPCGGGTMERHRTC 4790
Query: 274 TNPAPLNGGAFCEGQ-AFQKTACT-TICPVDGAWTEWSKWSACSTE--CAHWRSRE---C 326
G A C+ Q Q+ C CP SAC+T C W + C
Sbjct: 4791 EGGP---GVAPCQAQDTEQRQECNLQPCP---ECPPGQVLSACATSCPCLCWHLQPGAIC 4844
Query: 327 MAPPPQNGGRDCSGTLLDSKNC 348
+ P Q G G LL + C
Sbjct: 4845 VQEPCQPGCGCPGGQLLHNGTC 4866
Score = 40.8 bits (94), Expect = 0.006
Identities = 20/54 (37%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 245 VNGGWSSWAEWSPCSNRCG-RGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT 297
V+ GWSSW+ W+ C CG + Q R+ NP P G C G + C T
Sbjct: 1908 VDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQT 1961
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/112 (29%), Positives = 41/112 (36%), Gaps = 24/112 (21%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRT--------CTNP---APLNGGAFCEGQAFQKTACTT 297
WS W WSPC C G++ R R C P NGG E +A Q T T
Sbjct: 4618 WSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQESCNGGPCPECEA-QDTVFTL 4676
Query: 298 ICPVDGAWTEWSKWSACSTECAH-WRSRECMAPPPQNGGRDCSGTLLDSKNC 348
C + C CA W +C+ P + G R G L+ C
Sbjct: 4677 DCA-----------NQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGRC 4717
Score = 39.3 bits (90), Expect = 0.018
Identities = 17/53 (32%), Positives = 22/53 (41%), Gaps = 3/53 (5%)
Query: 299 CPVDGAWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
CP+ W+ WS W+ C C R R PP GG C G + + C
Sbjct: 2712 CPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGC 2764
Score = 37.7 bits (86), Expect = 0.051
Identities = 30/120 (25%), Positives = 36/120 (30%), Gaps = 42/120 (35%)
Query: 250 SSWAEWSPCS-------------NRCGRGW------------------QKRTRTCTNPA- 277
S W+EWSPC W Q R R C +PA
Sbjct: 4526 SEWSEWSPCGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPAT 4585
Query: 278 --PLNGGA-FCEGQAFQKTACTT--ICPVDGAWTEWSKWSACSTECA-----HWRSRECM 327
P G C Q+ C CP W+ W WS C C+ WR E +
Sbjct: 4586 GRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEAL 4645
Score = 37.0 bits (84), Expect = 0.087
Identities = 17/47 (36%), Positives = 21/47 (44%), Gaps = 4/47 (8%)
Query: 302 DGAWTEWSKWSACSTECA----HWRSRECMAPPPQNGGRDCSGTLLD 344
DG + WS W CS C RSR+C+ P G+ C G D
Sbjct: 3811 DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPRQD 3857
Score = 34.3 bits (77), Expect = 0.56
Identities = 20/66 (30%), Positives = 26/66 (39%), Gaps = 14/66 (21%)
Query: 258 CSNRCGRGWQKRTR---TCTNPAPLNGGAFCEGQAFQKTACTTICP--VDGAWTEWSKWS 312
C++ G W ++ C N C QA Q + CP AW+ WS WS
Sbjct: 4119 CTDAQGHSWAPGSQHQDACNN---------CSCQAGQLSCTAQPCPPPTHCAWSHWSAWS 4169
Query: 313 ACSTEC 318
CS C
Sbjct: 4170 PCSHSC 4175
Score = 30.8 bits (68), Expect = 6.2
Identities = 30/103 (29%), Positives = 40/103 (38%), Gaps = 10/103 (9%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAP--LNGGAFCEGQAFQKTACTTICPVDGAWT 306
WSSW+ W+ CS C Q+R R PA GA C C + + T
Sbjct: 4368 WSSWSSWTRCS--CRVLVQQRYRH-QGPASRGARAGAPCTRLDGHFRPCLISNCSEDSCT 4424
Query: 307 EWSKWSACSTECA-----HWRSRECMAPPPQNGGRDCSGTLLD 344
++ AC + CA H + C PP G C LL+
Sbjct: 4425 PPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLE 4467
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 75.5 bits (184), Expect = 2e-13
Identities = 66/238 (27%), Positives = 106/238 (44%), Gaps = 22/238 (9%)
Query: 11 LLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCR 70
LL+ ++ W + + G GS + + FP P ++ P D + K +P L C+
Sbjct: 19 LLMMTVVFWGHQGN--GQGQGSRLRQEDFP-------PRIVEHPSDVIVSKGEPTTLNCK 69
Query: 71 A--FPATQIYFKCNGEWV--SQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDY 126
A P I + +GE V ++D + L + L + + R + +E Y
Sbjct: 70 AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI-VHGRRSKPDE----GSY 124
Query: 127 WCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVE 186
CVA + G SR A + +A LR +F Q P V +L+C+PP G P +
Sbjct: 125 --VCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIY 182
Query: 187 WLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVY 244
W K++ ID ++ + L+I R SD YTCV N+V +R S A + V+
Sbjct: 183 WKKDKVRIDDKEER--ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF 238
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/196 (24%), Positives = 83/196 (42%), Gaps = 24/196 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P L C R P IY+K D V + +E +R
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK--------KDKVRIDDKEERISIRGG 202
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ ++ CV + G S A + + + R F + P+ + V
Sbjct: 203 KLMISNTRKSDAGMY-------TCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 254
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
+ V +C+ +G P V W K++ + + + + D+ L I++ +D Y C+
Sbjct: 255 EEAVEFRCQV-QGDPQPTVRWKKDDADLPRGR---YDIKDDYTLRIKKTMSTDEGTYMCI 310
Query: 227 AKNIVAK-RRSTTATV 241
A+N V K S T TV
Sbjct: 311 AENRVGKMEASATLTV 326
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 157 QEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQAR 216
Q P + + +D LL+C+ G P+ + WLK E P +D + L I+ R
Sbjct: 438 QGPANQTLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLR 495
Query: 217 LSDTANYTCVA 227
+SDT YTCVA
Sbjct: 496 ISDTGTYTCVA 506
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 73.6 bits (179), Expect = 8e-13
Identities = 62/218 (28%), Positives = 97/218 (44%), Gaps = 20/218 (9%)
Query: 31 GSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWV-- 86
GS + + FP P ++ P D + K +P L C+A P I + +GE V
Sbjct: 21 GSRLRQEDFP-------PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET 73
Query: 87 SQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYV 146
++D + L + L + + R + +E Y CVA + G SR A +
Sbjct: 74 DKDDPRSHRMLLPSGSLFFLRI-VHGRRSKPDE----GSY--VCVARNYLGEAVSRNASL 126
Query: 147 RIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTI 206
+A LR +F Q P V +L+C+PP G P + W K++ ID ++ +
Sbjct: 127 EVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER--ISIR 184
Query: 207 DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVY 244
L+I R SD YTCV N+V +R S A + V+
Sbjct: 185 GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF 222
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/196 (24%), Positives = 83/196 (42%), Gaps = 24/196 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P L C R P IY+K D V + +E +R
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK--------KDKVRIDDKEERISIRGG 186
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ ++ CV + G S A + + + R F + P+ + V
Sbjct: 187 KLMISNTRKSDAGMY-------TCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 238
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
+ V +C+ +G P V W K++ + + + + D+ L I++ +D Y C+
Sbjct: 239 EEAVEFRCQV-QGDPQPTVRWKKDDADLPRGR---YDIKDDYTLRIKKTMSTDEGTYMCI 294
Query: 227 AKNIVAK-RRSTTATV 241
A+N V K S T TV
Sbjct: 295 AENRVGKMEASATLTV 310
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 157 QEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQAR 216
Q P + + +D LL+C+ G P+ + WLK E P +D + L I+ R
Sbjct: 422 QGPANQTLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLR 479
Query: 217 LSDTANYTCVA 227
+SDT YTCVA
Sbjct: 480 ISDTGTYTCVA 490
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 71.6 bits (174), Expect = 3e-12
Identities = 38/85 (44%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Query: 543 SSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPL--SEGTQTV 600
++ G F GG LS TGVS+++P GAIP+G E+Y + + S LP E +T+
Sbjct: 1554 ATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETL 1613
Query: 601 LSPSVTCGPTGLLLCRPVILTMPHC 625
LSP V CGP GL +PV L +PHC
Sbjct: 1614 LSPLVMCGPHGLKFLKPVELRLPHC 1638
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 71.6 bits (174), Expect = 3e-12
Identities = 38/85 (44%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Query: 543 SSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPL--SEGTQTV 600
++ G F GG LS TGVS+++P GAIP+G E+Y + + S LP E +T+
Sbjct: 1634 ATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETL 1693
Query: 601 LSPSVTCGPTGLLLCRPVILTMPHC 625
LSP V CGP GL +PV L +PHC
Sbjct: 1694 LSPLVMCGPHGLKFLKPVELRLPHC 1718
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
SGS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 18 SGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 70
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 71 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 122
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 123 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 179
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 180 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/198 (26%), Positives = 83/198 (41%), Gaps = 24/198 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 184
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 185 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 227 AKNIVAK-RRSTTATVIV 243
A+N+V K S T TV V
Sbjct: 293 AENMVGKAEASATLTVQV 310
Score = 48.5 bits (114), Expect = 3e-05
Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 20/192 (10%)
Query: 44 AEPLPYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEAT 101
+EP P+F+ +P+D + + V +C A P I+++ G SQN + + ++
Sbjct: 312 SEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSS 367
Query: 102 GLRVREV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----F 155
V + + ++ Q ++ Y CQ + + + TK AY+ + + +
Sbjct: 368 RFSVSQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVI 421
Query: 156 DQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQA 215
Q P+ + V +D +L C G PV + W K + V+ TQD+ + L IR A
Sbjct: 422 RQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYA 479
Query: 216 RLSDTANYTCVA 227
+L DT YTC+A
Sbjct: 480 KLGDTGRYTCIA 491
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
SGS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 18 SGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 70
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 71 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 122
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 123 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 179
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 180 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/198 (26%), Positives = 83/198 (41%), Gaps = 24/198 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 184
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 185 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 227 AKNIVAK-RRSTTATVIV 243
A+N+V K S T TV V
Sbjct: 293 AENMVGKAEASATLTVQV 310
Score = 48.5 bits (114), Expect = 3e-05
Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 20/192 (10%)
Query: 44 AEPLPYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEAT 101
+EP P+F+ +P+D + + V +C A P I+++ G SQN + + ++
Sbjct: 312 SEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSS 367
Query: 102 GLRVREV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----F 155
V + + ++ Q ++ Y CQ + + + TK AY+ + + +
Sbjct: 368 RFSVSQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVI 421
Query: 156 DQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQA 215
Q P+ + V +D +L C G PV + W K + V+ TQD+ + L IR A
Sbjct: 422 RQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYA 479
Query: 216 RLSDTANYTCVA 227
+L DT YTC+A
Sbjct: 480 KLGDTGRYTCIA 491
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
SGS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 18 SGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 70
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 71 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 122
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 123 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 179
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 180 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/196 (26%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 184
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 185 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 227 AKNIVAK-RRSTTATV 241
A+N+V K S T TV
Sbjct: 293 AENMVGKAEASATLTV 308
Score = 48.1 bits (113), Expect = 4e-05
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 19/188 (10%)
Query: 48 PYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEATGLRV 105
P+F+ +P+D + + V +C A P I+++ G SQN + + ++ V
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSSRFSV 368
Query: 106 REV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----FDQEP 159
+ + ++ Q ++ Y CQ + + + TK AY+ + + + Q P
Sbjct: 369 SQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGP 422
Query: 160 LGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSD 219
+ + V +D +L C G PV + W K + V+ TQD+ + L IR A+L D
Sbjct: 423 VNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLGD 480
Query: 220 TANYTCVA 227
T YTC+A
Sbjct: 481 TGRYTCIA 488
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
SGS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 18 SGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 70
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 71 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 122
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 123 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 179
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 180 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/198 (26%), Positives = 83/198 (41%), Gaps = 24/198 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 184
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 185 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 227 AKNIVAK-RRSTTATVIV 243
A+N+V K S T TV V
Sbjct: 293 AENMVGKAEASATLTVQV 310
Score = 48.5 bits (114), Expect = 3e-05
Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 20/192 (10%)
Query: 44 AEPLPYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEAT 101
+EP P+F+ +P+D + + V +C A P I+++ G SQN + + ++
Sbjct: 312 SEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSS 367
Query: 102 GLRVREV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----F 155
V + + ++ Q ++ Y CQ + + + TK AY+ + + +
Sbjct: 368 RFSVSQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVI 421
Query: 156 DQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQA 215
Q P+ + V +D +L C G PV + W K + V+ TQD+ + L IR A
Sbjct: 422 RQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYA 479
Query: 216 RLSDTANYTCVA 227
+L DT YTC+A
Sbjct: 480 KLGDTGRYTCIA 491
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 71.2 bits (173), Expect = 4e-12
Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
SGS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 18 SGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 70
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 71 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 122
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 123 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 179
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 180 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/198 (26%), Positives = 83/198 (41%), Gaps = 24/198 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 184
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 185 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 227 AKNIVAK-RRSTTATVIV 243
A+N+V K S T TV V
Sbjct: 293 AENMVGKAEASATLTVQV 310
Score = 48.5 bits (114), Expect = 3e-05
Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 20/192 (10%)
Query: 44 AEPLPYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEAT 101
+EP P+F+ +P+D + + V +C A P I+++ G SQN + + ++
Sbjct: 312 SEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSS 367
Query: 102 GLRVREV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----F 155
V + + ++ Q ++ Y CQ + + + TK AY+ + + +
Sbjct: 368 RFSVSQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVI 421
Query: 156 DQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQA 215
Q P+ + V +D +L C G PV + W K + V+ TQD+ + L IR A
Sbjct: 422 RQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYA 479
Query: 216 RLSDTANYTCVA 227
+L DT YTC+A
Sbjct: 480 KLGDTGRYTCIA 491
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 70.1 bits (170), Expect = 9e-12
Identities = 60/220 (27%), Positives = 92/220 (41%), Gaps = 24/220 (10%)
Query: 30 SGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRA--FPATQIYFKCNGEWVS 87
+GS + + FP P ++ P D + K +P L C+A P I + GE V
Sbjct: 57 TGSRLRQEDFP-------PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVE 109
Query: 88 QNDHVTQEG---LDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRA 144
+ + L + +R V SR ++ CVA + G S A
Sbjct: 110 TDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP--------DEGVYVCVARNYLGEAVSHNA 161
Query: 145 YVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLL 204
+ +A LR +F Q P V + +++C+PP G P + W K+ P D + +
Sbjct: 162 SLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERI 218
Query: 205 TI-DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
TI L+I R SD Y CV N+V +R S A + V
Sbjct: 219 TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 258
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/196 (26%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P D + +P + C R P I +K +G + D E +R
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD--------ERITIRGG 223
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
++ I +R+ + CV + G +S A + + R +F + P V +
Sbjct: 224 KLMITYTRKSDAGKY-------VCVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 275
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D +C G PV V W K++ + ++ + + DH L IR+ D +YTCV
Sbjct: 276 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCV 331
Query: 227 AKNIVAK-RRSTTATV 241
A+N+V K S T TV
Sbjct: 332 AENMVGKAEASATLTV 347
Score = 48.1 bits (113), Expect = 4e-05
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 19/188 (10%)
Query: 48 PYFLQEPQDAYIVKNKPVELRCRAF--PATQIYFKCNGEWVSQNDHVTQEGLDEATGLRV 105
P+F+ +P+D + + V +C A P I+++ G SQN + + ++ V
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG---SQNLLFSYQPPQSSSRFSV 407
Query: 106 REV-QIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKN-----FDQEP 159
+ + ++ Q ++ Y CQ + + + TK AY+ + + + Q P
Sbjct: 408 SQTGDLTITNVQRSDV---GYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGP 461
Query: 160 LGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSD 219
+ + V +D +L C G PV + W K + V+ TQD+ + L IR A+L D
Sbjct: 462 VNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLGD 519
Query: 220 TANYTCVA 227
T YTC+A
Sbjct: 520 TGRYTCIA 527
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 68.6 bits (166), Expect = 3e-11
Identities = 29/58 (50%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 246 NGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICPVD 302
+G WS W+ WSPCS CG G R+R CTNP P +GG FCEG C + CP D
Sbjct: 586 HGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRD 643
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/97 (29%), Positives = 38/97 (39%), Gaps = 3/97 (3%)
Query: 260 NRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECA 319
+R GR + + +C G K P G W++WS WS CS C
Sbjct: 544 HRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCG 603
Query: 320 ---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
RSR C P P +GG+ C G+ K C C
Sbjct: 604 GGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKC 640
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/79 (36%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 249 WSSWAEWSPCSNRCGRGWQKRTRTC--TNP---APLNGGAFC--EGQAFQKTACTTICPV 301
WS+ W+ CS+ CG+GW+KR C TNP A L A C E + AC
Sbjct: 990 WSA-GPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH 1048
Query: 302 DGAWTEW--SKWSACSTEC 318
+W S WS CS C
Sbjct: 1049 KPKKLQWLVSAWSQCSVTC 1067
Score = 40.0 bits (92), Expect = 0.010
Identities = 32/101 (31%), Positives = 41/101 (40%), Gaps = 12/101 (11%)
Query: 233 KRRSTTATVIVYVNGGWSSWA--EWSPCSNRCGRGWQKRTRTCT-----NPAPLNGGAFC 285
K R T V V+ SW+ WS CS CG G Q R CT + P+
Sbjct: 912 KTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP 971
Query: 286 EGQAFQKTACTT-ICPVDGAWTEWSKWSACSTECAH-WRSR 324
+ + AC + CP AW+ W+ CS C WR R
Sbjct: 972 QPAPSSRQACNSQSCP--PAWSA-GPWAECSHTCGKGWRKR 1009
Score = 37.0 bits (84), Expect = 0.087
Identities = 36/122 (29%), Positives = 43/122 (35%), Gaps = 29/122 (23%)
Query: 255 WSPCSNRCGRGWQKRTRTCTNP---------APLNGGAFCEGQAFQKTACTTI-C----- 299
WS CS C RG QKR C A + + AC + C
Sbjct: 1060 WSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPP 1119
Query: 300 -----PVDGAWTEWSKWSACSTEC---AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDG 351
P G+W S WS C+ C RS +C+A GGR SG LL K
Sbjct: 1120 FAAAGPSRGSWFA-SPWSQCTASCGGGVQTRSVQCLA-----GGRPASGCLLHQKPSASL 1173
Query: 352 LC 353
C
Sbjct: 1174 AC 1175
Score = 30.8 bits (68), Expect = 6.2
Identities = 17/56 (30%), Positives = 23/56 (41%), Gaps = 2/56 (3%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICPV 301
G W + + WS C+ CG G Q R+ C G + AC T CP+
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPI 1182
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 67.4 bits (163), Expect = 6e-11
Identities = 58/217 (26%), Positives = 87/217 (40%), Gaps = 13/217 (5%)
Query: 34 VLPDSFPS------APAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVS 87
+LP PS P + +P +++P D + + +P L CRA + N EW
Sbjct: 44 LLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRP----RPNIEWYK 99
Query: 88 QNDHVTQEGLD-EATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYV 146
V D A L + + R ++ CVA + G SR A +
Sbjct: 100 NGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASL 159
Query: 147 RIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTI 206
+A LR +F Q P V + +L+C PP G P V W K D ++ +
Sbjct: 160 EVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRK--DGARLKEEEGRITIR 217
Query: 207 DHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIV 243
L++ SD Y CVA N+ +R S A V+V
Sbjct: 218 GGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV 254
Score = 45.1 bits (105), Expect = 3e-04
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 23/191 (12%)
Query: 50 FLQEPQDAYIVKNKPVELRC---RAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVR 106
F Q P + + +P L C R P + ++ +G + + +EG
Sbjct: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKE-----EEG---------- 212
Query: 107 EVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPL 166
+ I + + + CVA + AG +S A V + R +F + P+ + V
Sbjct: 213 RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLE-RPSFLRRPVNQVVLA 271
Query: 167 DHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCV 226
D V C +G P + W K + + PT + + DH+L I D YTCV
Sbjct: 272 DAPVTFLCEV-KGDPPPRLRWRKEDGEL-PTG--RYEIRSDHSLWIGHVSAEDEGTYTCV 327
Query: 227 AKNIVAKRRST 237
A+N V + ++
Sbjct: 328 AENSVGRAEAS 338
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 65.9 bits (159), Expect = 2e-10
Identities = 28/61 (45%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT-ICPVDGAW 305
GGW W W CS CG G Q +R CT P P NGG +CEG+ + +C T CP A
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
Query: 306 T 306
T
Sbjct: 581 T 581
Score = 47.4 bits (111), Expect = 6e-05
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 300 PVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLC 353
P G W W W CS C + SR+C P P+NGG+ C G ++C C
Sbjct: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 65.9 bits (159), Expect = 2e-10
Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 7/110 (6%)
Query: 250 SSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDGAWTEW 308
S W+EWS CS CG+G + R R + A L C Q C CP+D TEW
Sbjct: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGD---CNEDLEQVEKCMLPECPIDCELTEW 674
Query: 309 SKWSACSTEC--AHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQN 356
S+WS C+ C H + PQ GG C T + K C C++N
Sbjct: 675 SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPET-VQRKKCRIRKCLRN 723
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/103 (28%), Positives = 36/103 (34%), Gaps = 6/103 (5%)
Query: 250 SSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT---ICPVDGAWT 306
S W WSPCS CG G + R R G+ C + CT P T
Sbjct: 505 SEWITWSPCSISCGMGMRSRERYVKQFP--EDGSVCTLPTEETEKCTVNEECSPSSCLMT 562
Query: 307 EWSKWSACSTECA-HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
EW +W CS C + R M G C ++ C
Sbjct: 563 EWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC 605
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/107 (31%), Positives = 47/107 (43%), Gaps = 8/107 (7%)
Query: 249 WSSWAEWSPC-SNRCGRGWQKRTRTCTNPAPLNGGAFC-EGQAFQKTACTTICPVDGA-- 304
+S+W+ WS C S+ C +G KR R A L+ C + Q FQ DG+
Sbjct: 445 YSNWSPWSACSSSTCDKG--KRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTC 502
Query: 305 -WTEWSKWSACSTECA-HWRSRECMAPPPQNGGRDCSGTLLDSKNCT 349
+EW WS CS C RSRE G C+ +++ CT
Sbjct: 503 TMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCT 549
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,995,530
Number of Sequences: 37866
Number of extensions: 2065842
Number of successful extensions: 6803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 5430
Number of HSP's gapped (non-prelim): 1179
length of query: 945
length of database: 18,247,518
effective HSP length: 112
effective length of query: 833
effective length of database: 14,006,526
effective search space: 11667436158
effective search space used: 11667436158
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.