Search of human proteins with 31657136

Search of human proteins with 31657136

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
         (633 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31657136 follicle stimulating hormone receptor isoform 2 prec...  1270   0.0  
gi|31657138 follicle stimulating hormone receptor isoform 1 prec...  1165   0.0  
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre...   569   e-162
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu...   469   e-132
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   185   1e-46
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   181   1e-45
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...   175   1e-43
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   165   1e-40
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   165   1e-40
gi|62912474 leucine-rich repeat-containing G protein-coupled rec...   165   1e-40
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo...   151   2e-36
gi|217330610 thyroid stimulating hormone receptor isoform 3 prec...   128   2e-29
gi|64085161 thyroid stimulating hormone receptor isoform 2 precu...   125   2e-28
gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]                   83   9e-16
gi|71999131 opsin 3 [Homo sapiens]                                     77   5e-14
gi|4557859 somatostatin receptor 2 [Homo sapiens]                      74   4e-13
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]              74   4e-13
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            74   4e-13
gi|5174593 melatonin receptor 1A [Homo sapiens]                        74   5e-13
gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens]                   74   5e-13
gi|51317373 netrin-G1 ligand [Homo sapiens]                            72   1e-12
gi|15150803 opsin 4 isoform 1 [Homo sapiens]                           72   2e-12
gi|5921992 adenosine A2a receptor [Homo sapiens]                       72   2e-12
gi|4506527 rhodopsin [Homo sapiens]                                    71   3e-12
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          70   8e-12
gi|4759146 slit homolog 2 [Homo sapiens]                               69   1e-11
gi|23238240 angiotensin II receptor, type 2 [Homo sapiens]             68   2e-11
gi|11321571 slit homolog 3 [Homo sapiens]                              68   3e-11
gi|157426873 tachykinin receptor 2 [Homo sapiens]                      67   4e-11
gi|188528675 slit homolog 1 [Homo sapiens]                             67   4e-11

>gi|31657136 follicle stimulating hormone receptor isoform 2
           precursor [Homo sapiens]
          Length = 633

 Score = 1270 bits (3286), Expect = 0.0
 Identities = 633/633 (100%), Positives = 633/633 (100%)

Query: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
Sbjct: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60

Query: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
           IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
Sbjct: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120

Query: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180
           NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
Sbjct: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180

Query: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILSELHPICNKSILRQEVD 240
           GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILSELHPICNKSILRQEVD
Sbjct: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILSELHPICNKSILRQEVD 240

Query: 241 YMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGY 300
           YMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGY
Sbjct: 241 YMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGY 300

Query: 301 NILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVD 360
           NILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVD
Sbjct: 301 NILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVD 360

Query: 361 IHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQ 420
           IHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQ
Sbjct: 361 IHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQ 420

Query: 421 LRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAF 480
           LRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAF
Sbjct: 421 LRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAF 480

Query: 481 VVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 540
           VVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI
Sbjct: 481 VVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 540

Query: 541 TVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTV 600
           TVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTV
Sbjct: 541 TVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTV 600

Query: 601 HNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 633
           HNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
Sbjct: 601 HNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 633


>gi|31657138 follicle stimulating hormone receptor isoform 1
           precursor [Homo sapiens]
          Length = 695

 Score = 1165 bits (3013), Expect = 0.0
 Identities = 604/695 (86%), Positives = 612/695 (88%), Gaps = 62/695 (8%)

Query: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
Sbjct: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60

Query: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
           IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
Sbjct: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120

Query: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180
           NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
Sbjct: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180

Query: 181 GIQ------------------------EIHNCAFNGTQ---------------------- 194
           GIQ                        E+ N  F+G                        
Sbjct: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN 240

Query: 195 LDELNLSDNNNLEELP----------------NDVFHGASGPVILSELHPICNKSILRQE 238
           L +L      NL++LP                +     A+    +SELHPICNKSILRQE
Sbjct: 241 LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE 300

Query: 239 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 298
           VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM
Sbjct: 301 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 360

Query: 299 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 358
           GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
Sbjct: 361 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 420

Query: 359 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 418
           VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK
Sbjct: 421 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 480

Query: 419 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 478
           VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
Sbjct: 481 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 540

Query: 479 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 538
           AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP
Sbjct: 541 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600

Query: 539 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 598
           LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS
Sbjct: 601 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 660

Query: 599 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 633
           TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
Sbjct: 661 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 695


>gi|106067657 luteinizing hormone/choriogonadotropin receptor
           precursor [Homo sapiens]
          Length = 699

 Score =  569 bits (1467), Expect = e-162
 Identities = 304/612 (49%), Positives = 408/612 (66%), Gaps = 59/612 (9%)

Query: 58  LRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQ 117
           ++VI   AF G  ++ KIEISQ D LE IEA+ F NL  L EI I+   NL YI P AF 
Sbjct: 61  VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI 120

Query: 118 NLPNLQYLLISNTGIKHLPDVHKIHSLQK-VLLDIQDNINIHTIERNSFVGLSFESVILW 176
           NLP L+YL I NTGI+  PDV K+ S +   +L+I DN++I TI  N+F G++ ESV L 
Sbjct: 121 NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK 180

Query: 177 LNKNGIQEIHNCAFNGT------------------------------------------- 193
           L  NG +E+ + AFNGT                                           
Sbjct: 181 LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY 240

Query: 194 ---QLDELNLSDNNNLEELPN-DVFHGASGPVILSELHPICNKSILRQEVDYMTQARGQR 249
               +  L  + + +L++LP+ + F       +    H    +++  +E ++        
Sbjct: 241 GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF 300

Query: 250 SSLAE------DNESSYSRGF---DMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGY 300
           S   E      +N++ YS      +++  +++Y  C       C+P+PDAFNPCEDIMGY
Sbjct: 301 SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTP-RCAPEPDAFNPCEDIMGY 359

Query: 301 NILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVD 360
           + LRVLIW I+ILAI GN+ VL +L TS+YKLTVPRFLMCNL+FAD C+G+YLLLIASVD
Sbjct: 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVD 419

Query: 361 IHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQ 420
             TK QY+N+AIDWQTG+GC  AGFFTVFASELSVYTLT ITLERWHTIT+A+ LD K++
Sbjct: 420 SQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLR 479

Query: 421 LRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAF 480
           LRHA  +M+ GW+F+   A+ P+ G+S+YMKVSIC PMD+++ LSQ+Y++++L+LNV+AF
Sbjct: 480 LRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAF 539

Query: 481 VVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 540
            +IC CYI IY  VRNP +++++ DT+IAK+MA+LIFTDF CMAPISFFAISA+ KVPLI
Sbjct: 540 FIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLI 599

Query: 541 TVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTV 600
           TV+ +K+LLVLF+PINSCANPFLYAIFTK F+RDFF+LLSK GC + +A++YR +  S  
Sbjct: 600 TVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFS-A 658

Query: 601 HNTHPRNGHCSS 612
           + ++ +NG   S
Sbjct: 659 YTSNCKNGFTGS 670


>gi|64085121 thyroid stimulating hormone receptor isoform 1
           precursor [Homo sapiens]
          Length = 764

 Score =  469 bits (1208), Expect = e-132
 Identities = 258/537 (48%), Positives = 345/537 (64%), Gaps = 25/537 (4%)

Query: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNL---PKLHEIRIEKANNLLYINPEAFQ 117
           +Q  AF+G   L+ + +++N  L VI+ D F  +   P L ++       L        +
Sbjct: 192 VQGYAFNGT-KLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTAL------PSK 244

Query: 118 NLPNLQYLLISNTG-IKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 176
            L +L+ L+  NT  +K LP    +  L     D+    +    +    +    ES  L 
Sbjct: 245 GLEHLKELIARNTWTLKKLP--LSLSFLHLTRADLSYPSHCCAFKNQKKIRGILES--LM 300

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILSELHPICNKSILR 236
            N++ +Q +         ++ LN   +   EE   D   G        + H   +  +  
Sbjct: 301 CNESSMQSLRQ----RKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFF 356

Query: 237 QEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCED 296
           +E +      GQ     ++ +    + FD  Y   DY +C +  D+ C+PK D FNPCED
Sbjct: 357 EEQEDEIIGFGQE---LKNPQEETLQAFDSHY---DYTICGDSEDMVCTPKSDEFNPCED 410

Query: 297 IMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLI 356
           IMGY  LR+++WF+S+LA+ GN+ VL+IL TS YKL VPRFLMCNLAFAD C+G+YLLLI
Sbjct: 411 IMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLI 470

Query: 357 ASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLD 416
           ASVD++T S+Y+N+AIDWQTG GC+ AGFFTVFASELSVYTLT ITLERW+ IT AM+LD
Sbjct: 471 ASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLD 530

Query: 417 CKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLN 476
            K++LRHA ++MV GW+  F  AL P+ GISSY KVSICLPMD ++PL+  Y++ +L LN
Sbjct: 531 RKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLN 590

Query: 477 VLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLK 536
           ++AFV++C CY+ IY+TVRNP       DT+IAKRMA+LIFTDF+CMAPISF+A+SA L 
Sbjct: 591 IVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILN 650

Query: 537 VPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYR 593
            PLITVS +KILLVLF+P+NSCANPFLYAIFTK F+RD FILLSK G  + QAQ YR
Sbjct: 651 KPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYR 707



 Score =  124 bits (311), Expect = 3e-28
 Identities = 83/227 (36%), Positives = 120/227 (52%), Gaps = 9/227 (3%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVIL 223
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +L
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  185 bits (470), Expect = 1e-46
 Identities = 153/586 (26%), Positives = 268/586 (45%), Gaps = 63/586 (10%)

Query: 47  NAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKAN 106
           N  EL F    +R I + AF G   L  I    N + + +    F +LP+L  + +  A+
Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI-QFVGRSAFQHLPELRTLTLNGAS 316

Query: 107 NLLYIN---------------------PEAFQN-LPNLQYLLISNTGIKHLPDVHKIHSL 144
            +                         P+   N LPNLQ L +S   ++ LP       L
Sbjct: 317 QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 376

Query: 145 QKVLLDIQDNINIHTIERNSFVGL-SFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSD 202
           QK+  D++ N  I+ I+ ++F  L S  S+ L  NK  I  IH  AF+    L +L+LS 
Sbjct: 377 QKI--DLRHN-EIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKLDLS- 430

Query: 203 NNNLEELPNDVFHG----------ASGPVILSELHP------------ICNKSILRQEVD 240
           +N L   P    HG          A   +I SE  P             C   +      
Sbjct: 431 SNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYK 490

Query: 241 YMTQ-ARGQRSSLAEDN-------ESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFN 292
              Q  +G  SS+ + +       ++   R  +    +F+ DL   +  V CSP P  F 
Sbjct: 491 ISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDL-KALHSVQCSPSPGPFK 549

Query: 293 PCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
           PCE ++   ++R+ +W I++LA+T N +V   +  S   ++  + L+  +A  ++  G+ 
Sbjct: 550 PCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVS 609

Query: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
             ++A VD  T   +  +   W+ G GC   GF ++FASE SV+ LT   LER  ++ ++
Sbjct: 610 SAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYS 669

Query: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSL 472
            + + K        ++++  + A   A  P+ G S Y    +CLP+    P +  Y+++L
Sbjct: 670 AKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVAL 729

Query: 473 LVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAIS 532
           ++LN L F+++   Y  +Y  +   ++  +  D  + K +A+L+FT+ +   P++F + S
Sbjct: 730 ILLNSLCFLMMTIAYTKLYCNLDKGDL-ENIWDCSMVKHIALLLFTNCILNCPVAFLSFS 788

Query: 533 ASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFIL 578
           + + +  I+    K +L++  P+ +C NP LY +F  +F+ D   L
Sbjct: 789 SLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSL 834



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 65/223 (29%), Positives = 103/223 (46%), Gaps = 39/223 (17%)

Query: 23  CHCS--NRVFL---CQESKVTEIPS---------DLPRNAI---------------ELRF 53
           CHC    R+ L   C +  ++E+PS         DL  N I               ELR 
Sbjct: 38  CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97

Query: 54  VLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINP 113
               L  I KGAF+G   L K+ + QN+ L  +  +   NL  L  +R++ AN++ Y+ P
Sbjct: 98  AGNALTYIPKGAFTGLYSL-KVLMLQNNQLRHVPTEALQNLRSLQSLRLD-ANHISYVPP 155

Query: 114 EAFQNLPNLQYLLISNTGIKHLP--DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFE 171
             F  L +L++L + +  +  +P      + +LQ + L +     IH I   +F  LS  
Sbjct: 156 SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN---KIHHIPDYAFGNLS-S 211

Query: 172 SVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLEELPNDV 213
            V+L L+ N I  +    F+G   L+ L+L + NNL+E P  +
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLDEFPTAI 253



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 45/203 (22%), Positives = 81/203 (39%), Gaps = 27/203 (13%)

Query: 34  ESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQ--NDVLEVIEADVF 91
           ++ +TEIP    R+   L+ +   L  I       FG+L  + +    N+ +  +    F
Sbjct: 171 DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCF 230

Query: 92  SNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDI 151
             L  L  + +   N  L   P A + L NL+ L   +  I+ +P+   + +   + +  
Sbjct: 231 DGLHSLETLDLNYNN--LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF 288

Query: 152 QDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDEL-NLSDNNNLEEL 209
            DN  I  + R++F                + E+     NG +Q+ E  +L+   NLE L
Sbjct: 289 YDN-PIQFVGRSAF--------------QHLPELRTLTLNGASQITEFPDLTGTANLESL 333

Query: 210 PNDVFHGASGPVILSELHPICNK 232
                   +G  I S    +CN+
Sbjct: 334 T------LTGAQISSLPQTVCNQ 350


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  181 bits (460), Expect = 1e-45
 Identities = 150/575 (26%), Positives = 266/575 (46%), Gaps = 57/575 (9%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
           EL F    + VI  GAF G   L  I +  N  L  +    F NL  LH + I  A+ + 
Sbjct: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASMVQ 310

Query: 109 -------------LYINPEAFQNLPN--------LQYLLISNTGIKHLPDVHKIHSLQKV 147
                        L +      ++PN        L+ L +S   I+ LP  +  H+L+++
Sbjct: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370

Query: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
            L  Q N  I+ I+  +F GL     IL L++N I EIH+ AF     +  L++S N  L
Sbjct: 371 SL--QRN-QIYQIKEGTFQGL-ISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNE-L 425

Query: 207 EELPNDVFHGAS-----GPVILSELHPICNKSILRQ-EVDYMTQARG------------- 247
              P +  +G +     G   L E     +   LR   V Y  Q                
Sbjct: 426 TSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTE 485

Query: 248 ----QRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNIL 303
               Q  S+A++  ++ +     T    ++      + + C+P   AF PCE ++G  ++
Sbjct: 486 DNSLQDHSVAQEKGTADAANVTSTLENEEHSQ----IIIHCTPSTGAFKPCEYLLGSWMI 541

Query: 304 RVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHT 363
           R+ +WFI ++A+  N++V++    S   L   +  +  ++ ++L +GIY  ++  +D  +
Sbjct: 542 RLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVS 601

Query: 364 KSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRH 423
             ++  + I W+TG+GC  AGF  VF+SE +++ L   T+ER  +    M+      L+ 
Sbjct: 602 WGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQ 661

Query: 424 AASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVI 483
                ++ ++ A  A  FP+F    Y    +CLP       S  + ++L++LN LAF+++
Sbjct: 662 FRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLM 721

Query: 484 CGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVS 543
              Y  +Y  +   ++ S +S + + K +A LIFT+ +   P++FF+ +  +    I+  
Sbjct: 722 AVIYTKLYCNLEKEDL-SENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE 780

Query: 544 KAKILLVLFHPINSCANPFLYAIFTKNFRRDFFIL 578
             K + ++F P+ +C NP LY  F   F+ D+ +L
Sbjct: 781 IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLL 815



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 45/154 (29%), Positives = 81/154 (52%), Gaps = 10/154 (6%)

Query: 73  EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
           + ++IS N++ ++ E D F N P L E+++   N+L +I+P+A   L  L+ L + N  +
Sbjct: 60  QALDISMNNITQLPE-DAFKNFPFLEELQLA-GNDLSFIHPKALSGLKELKVLTLQNNQL 117

Query: 133 KHLPD--VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIH-NCA 189
           K +P   +  + +LQ + LD     +I ++  +SF GL  +   LWL+ N + E+  +  
Sbjct: 118 KTVPSEAIRGLSALQSLRLDAN---HITSVPEDSFEGL-VQLRHLWLDDNSLTEVPVHPL 173

Query: 190 FNGTQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
            N   L  L L+  N +  +P+  F   S  V+L
Sbjct: 174 SNLPTLQALTLA-LNKISSIPDFAFTNLSSLVVL 206



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 41/160 (25%), Positives = 71/160 (44%), Gaps = 5/160 (3%)

Query: 57  KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAF 116
           +L+ +   A  G   L+ + +  N +  V E D F  L +L  + ++  N+L  +     
Sbjct: 116 QLKTVPSEAIRGLSALQSLRLDANHITSVPE-DSFEGLVQLRHLWLDD-NSLTEVPVHPL 173

Query: 117 QNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 176
            NLP LQ L ++   I  +PD    +    V+L + +N  I ++ ++ F GL      L 
Sbjct: 174 SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN-KIRSLSQHCFDGLD-NLETLD 231

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHG 216
           LN N + E          L EL    +N++  +P+  F G
Sbjct: 232 LNYNNLGEFPQAIKALPSLKELGF-HSNSISVIPDGAFDG 270


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score =  175 bits (444), Expect = 1e-43
 Identities = 148/567 (26%), Positives = 277/567 (48%), Gaps = 38/567 (6%)

Query: 33  QESKVTEIPSDLPRNAIELRFVL---TKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 89
           Q + + ++P D  +N  +L+ +     K+  I   AF G   L K+ +S N +   ++  
Sbjct: 134 QWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT-FLKPG 192

Query: 90  VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKV-L 148
           VF +L +L  + IE  N+L  I+P  F  L +L  L++ N  +  LPD      + ++  
Sbjct: 193 VFEDLHRLEWLIIED-NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHW 251

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLE 207
           LD++ N +IH +   +F+  S  +V++ + KN I  ++   F   Q LDEL+L  +N +E
Sbjct: 252 LDLEGN-HIHNLRNLTFISCSNLTVLV-MRKNKINHLNENTFAPLQKLDELDLG-SNKIE 308

Query: 208 ELPNDVFHGASGPVILSELHPICN--KSILRQEVDYMTQARG---QRSSLAEDNESSYSR 262
            LP  +F        LS+L+   N  + I   + DY+ + +    +   ++   +  +  
Sbjct: 309 NLPPLIFKDLKE---LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365

Query: 263 GFDMTYTEFD-YDLCNEVVDV-TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNII 320
             ++++  F  +  C     V +C P  D  +  E+++   I RV +W +S +   GNI 
Sbjct: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425

Query: 321 VLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGC 380
           V+ +    + +  +    + +L  AD  +GIYL +I   D+  + +Y+ +A  W     C
Sbjct: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485

Query: 381 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAAL 440
              G   + ++E+SV  LT +TLE++  I +  +     + R   +V+++ WI  F  A 
Sbjct: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAF 544

Query: 441 FPI----FGISSYMKVSICLPM---DIDSPLSQLYVMSL-LVLNVLAFVVICGCYIHIYL 492
            P+    F  + Y    +C P+   D +S  +Q+Y +++ L +N+ AF++I   Y  ++ 
Sbjct: 545 IPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY 604

Query: 493 TVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-TVSKA 545
           +V    I ++        +  +AKR   ++FTD LC  PI      + L+V +  T++  
Sbjct: 605 SVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW 664

Query: 546 KILLVLFHPINSCANPFLYAIFTKNFR 572
            ++ +L  PINS  NP LY + T+ F+
Sbjct: 665 VVIFIL--PINSALNPILYTLTTRPFK 689


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  165 bits (417), Expect = 1e-40
 Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 209 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 267

Query: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
                               + + P    Q LP L+ L +S+  I+ LP +H+   L+++
Sbjct: 268 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 327

Query: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
              +Q N  I  I  ++F  LS     L L+ N I+ IH  AF+    L +L+L+D N L
Sbjct: 328 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 382

Query: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
             LP     G       G + LS+     +   LR  EV Y  Q            A GQ
Sbjct: 383 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 442

Query: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
                L  D+E S  R   +        +D DL     E+ D      V CSP P  F P
Sbjct: 443 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 502

Query: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
           CE +     +R+ +W I +L++  N +++L +       L   +F++  +A A+   GI 
Sbjct: 503 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 562

Query: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
             L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE SV  LT   ++   +++  
Sbjct: 563 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 622

Query: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
                   L    + ++     A  AA  P+  +  Y    +CLP       P +  + +
Sbjct: 623 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 682

Query: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
           +L+++N   F+V+ G YI +Y  +   +   +  D  + + +A LIF D L   P++F +
Sbjct: 683 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 741

Query: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
            ++ L +  +T    K +L++  P+ +C NP LY +F  +FR D   L  + G      Y
Sbjct: 742 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 801

Query: 586 EMQAQIYRTETSST 599
               ++ ++   ST
Sbjct: 802 AAAGELEKSSCDST 815



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 58/192 (30%), Positives = 81/192 (42%), Gaps = 31/192 (16%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
           ELR     L  I   AFSG   L KI + QN+ L  I A+    LP L  +R++   NL+
Sbjct: 42  ELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLI 98

Query: 110 YINPE-------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSL 144
            + PE                         A  NLP LQ + ++   I H+PD    +  
Sbjct: 99  SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 158

Query: 145 QKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNN 204
             V+L + +N  I  +  +SF GL      L LN N +QE         +L EL    NN
Sbjct: 159 SLVVLHLHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNN 215

Query: 205 NLEELPNDVFHG 216
           N++ +P   F G
Sbjct: 216 NIKAIPEKAFMG 227



 Score = 33.9 bits (76), Expect = 0.47
 Identities = 35/144 (24%), Positives = 54/144 (37%), Gaps = 30/144 (20%)

Query: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--------------------------VH 139
           NNL  + P  F +L  L+ L +S   + H+P                           + 
Sbjct: 24  NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 83

Query: 140 KIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELN 199
           ++ SLQ + LD      I  +   SF GLS     LWL+ N + EI   A N     +  
Sbjct: 84  ELPSLQSLRLDAN---LISLVPERSFEGLS-SLRHLWLDDNALTEIPVRALNNLPALQAM 139

Query: 200 LSDNNNLEELPNDVFHGASGPVIL 223
               N +  +P+  F   +  V+L
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVL 163


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  165 bits (417), Expect = 1e-40
 Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 319

Query: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
                               + + P    Q LP L+ L +S+  I+ LP +H+   L+++
Sbjct: 320 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 379

Query: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
              +Q N  I  I  ++F  LS     L L+ N I+ IH  AF+    L +L+L+D N L
Sbjct: 380 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 434

Query: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
             LP     G       G + LS+     +   LR  EV Y  Q            A GQ
Sbjct: 435 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 494

Query: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
                L  D+E S  R   +        +D DL     E+ D      V CSP P  F P
Sbjct: 495 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 554

Query: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
           CE +     +R+ +W I +L++  N +++L +       L   +F++  +A A+   GI 
Sbjct: 555 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 614

Query: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
             L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE SV  LT   ++   +++  
Sbjct: 615 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 674

Query: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
                   L    + ++     A  AA  P+  +  Y    +CLP       P +  + +
Sbjct: 675 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 734

Query: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
           +L+++N   F+V+ G YI +Y  +   +   +  D  + + +A LIF D L   P++F +
Sbjct: 735 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 793

Query: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
            ++ L +  +T    K +L++  P+ +C NP LY +F  +FR D   L  + G      Y
Sbjct: 794 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 853

Query: 586 EMQAQIYRTETSST 599
               ++ ++   ST
Sbjct: 854 AAAGELEKSSCDST 867



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 62/246 (25%), Positives = 93/246 (37%), Gaps = 57/246 (23%)

Query: 23  CHCSNRVFL----CQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEIS 78
           CHC     +    C E  ++ +P DL      L   +  L  +Q G F     LE++ +S
Sbjct: 39  CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLS 98

Query: 79  -----------------------QNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPE- 114
                                  QN+ L  I A+    LP L  +R++   NL+ + PE 
Sbjct: 99  GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLISLVPER 156

Query: 115 ------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLD 150
                                   A  NLP LQ + ++   I H+PD    +    V+L 
Sbjct: 157 SFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLH 216

Query: 151 IQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELP 210
           + +N  I  +  +SF GL      L LN N +QE         +L EL    NNN++ +P
Sbjct: 217 LHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIP 273

Query: 211 NDVFHG 216
              F G
Sbjct: 274 EKAFMG 279


>gi|62912474 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 3 [Homo sapiens]
          Length = 828

 Score =  165 bits (417), Expect = 1e-40
 Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 180

Query: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
                               + + P    Q LP L+ L +S+  I+ LP +H+   L+++
Sbjct: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 240

Query: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
              +Q N  I  I  ++F  LS     L L+ N I+ IH  AF+    L +L+L+D N L
Sbjct: 241 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 295

Query: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
             LP     G       G + LS+     +   LR  EV Y  Q            A GQ
Sbjct: 296 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 355

Query: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
                L  D+E S  R   +        +D DL     E+ D      V CSP P  F P
Sbjct: 356 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 415

Query: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
           CE +     +R+ +W I +L++  N +++L +       L   +F++  +A A+   GI 
Sbjct: 416 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 475

Query: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
             L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE SV  LT   ++   +++  
Sbjct: 476 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 535

Query: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
                   L    + ++     A  AA  P+  +  Y    +CLP       P +  + +
Sbjct: 536 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 595

Query: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
           +L+++N   F+V+ G YI +Y  +   +   +  D  + + +A LIF D L   P++F +
Sbjct: 596 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 654

Query: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
            ++ L +  +T    K +L++  P+ +C NP LY +F  +FR D   L  + G      Y
Sbjct: 655 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 714

Query: 586 EMQAQIYRTETSST 599
               ++ ++   ST
Sbjct: 715 AAAGELEKSSCDST 728



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 25/122 (20%)

Query: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--VHKIHSLQKVLLDIQDNINIHTIERN 163
           NNL  + P  F +L  L+ L +S   + H+P      ++SL K+L+          ++ N
Sbjct: 33  NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL-KILM----------LQNN 81

Query: 164 SFVGLSFESVILW---------LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVF 214
              G+  E+  LW         LN N +QE         +L EL    NNN++ +P   F
Sbjct: 82  QLGGIPAEA--LWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIPEKAF 138

Query: 215 HG 216
            G
Sbjct: 139 MG 140


>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
           sapiens]
          Length = 754

 Score =  151 bits (381), Expect = 2e-36
 Identities = 141/585 (24%), Positives = 278/585 (47%), Gaps = 41/585 (7%)

Query: 26  SNRVFLC--QESKVTEIPSDLPRNAIELRFVLTK---LRVIQKGAFSGFGDLEKIEISQN 80
           SN V L   +++K+  +P  +     +L+ +  +   +R I + AF G  +L+ + ++ N
Sbjct: 136 SNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHN 195

Query: 81  DVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHK 140
             +  +   +F +L +L  + ++  N +  I+   F  L +L +L + N  ++ LP    
Sbjct: 196 -CITTLRPGIFKDLHQLTWLILDD-NPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMC 253

Query: 141 IHSLQKVLLDIQDNINIHTIERNSFVGLSFESV-ILWLNKNGIQEIHNCAFNGTQ-LDEL 198
               Q   +D++ N  I  +  ++F  LS +S+ +L+L +N I  +    F+  + L EL
Sbjct: 254 AQMPQLNWVDLEGN-RIKYLTNSTF--LSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGEL 310

Query: 199 NLSDNNNLEELPNDVFHGASGPVILSELHPICNKSIL--RQEVDYMTQARG---QRSSLA 253
           +LS +N + EL   +F       +L +L+   N  +   + + + + Q +    +R  + 
Sbjct: 311 DLS-SNTITELSPHLFKDLK---LLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIP 366

Query: 254 EDNESSYSRGFDMTYTEF-DYDLCNEVVDVT-CSPKPDAFNPCEDIMGYNILRVLIWFIS 311
             N   +    ++++  F ++  C+    V  C P  D  +  ED++  NILR+ +W I+
Sbjct: 367 NINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIA 426

Query: 312 ILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYA 371
            +   GN+ V+ + +  + + T     +  L  AD  +G+YL  +   DI  + QY  YA
Sbjct: 427 FITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYA 486

Query: 372 IDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMG 431
           + W     C   GF  + ++E+SV  LT +TLE++  I      + +   R  + +++  
Sbjct: 487 LLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFS-NIRPGKRQTSVILICI 545

Query: 432 WIFAFAAALFPI-----FGISSYMKVSICLPMDIDSPL---SQLYVMSL-LVLNVLAFVV 482
           W+  F  A+ P      FG + Y K  +C P+  D      S+ Y + + L +N+LAF++
Sbjct: 546 WMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLI 604

Query: 483 ICGCYIHIYLTVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLK 536
           I   YI ++ +++   + ++        +  +A R   ++F+D +C  P+    I +  +
Sbjct: 605 IVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFR 664

Query: 537 VPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSK 581
           V  I  +    +++ F P+NS  NP LY + T  F+     LL K
Sbjct: 665 VE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHK 708


>gi|217330610 thyroid stimulating hormone receptor isoform 3
           precursor [Homo sapiens]
          Length = 274

 Score =  128 bits (321), Expect = 2e-29
 Identities = 88/263 (33%), Positives = 134/263 (50%), Gaps = 9/263 (3%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVILSELHPICNKSILR 236
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +L E   +  K   +
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLVENVAVSGKGFCK 244

Query: 237 QEVDYMTQARGQRSSLAEDNESS 259
               ++ +    R SL+ + + +
Sbjct: 245 SLFSWLYRLPLGRKSLSFETQKA 267


>gi|64085161 thyroid stimulating hormone receptor isoform 2
           precursor [Homo sapiens]
          Length = 253

 Score =  125 bits (313), Expect = 2e-28
 Identities = 90/256 (35%), Positives = 132/256 (51%), Gaps = 18/256 (7%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVILSELHPICNKSILR 236
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +L  L         R
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLLPLG--------R 236

Query: 237 QEVDYMTQARGQRSSL 252
           + + + TQ +  RSS+
Sbjct: 237 KSLSFETQ-KAPRSSM 251


>gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]
          Length = 384

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 78/318 (24%), Positives = 126/318 (39%), Gaps = 37/318 (11%)

Query: 310 ISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHN 369
           + IL ++GN+ +++I+   +    V   L+ NL+F+DL + I  L    V        + 
Sbjct: 50  VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV--------YT 101

Query: 370 YAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 428
               W  G A C    F    +  +S+++L  I +ER   I +      +   RHA   +
Sbjct: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR--GWRPNNRHAYVGI 159

Query: 429 VMGWIFAFAAAL------------FPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLN 476
            + W+ A A++L            F    + +Y    +C            Y   LLVL 
Sbjct: 160 AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219

Query: 477 V---LAFVVICGCYIHIYLTVRN-------PNIVSSSSDTRIAKRMAMLIFTDFLCMAPI 526
               L F+ IC   I+I L  RN        N   SS   RI   +  ++    +C  P+
Sbjct: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPL 279

Query: 527 SFFAISASLKVPLITVSKAKILLVLFH---PINSCANPFLYAIFTKNFRRDFFILLSKCG 583
           + F         +I      +L +L H    I++C NP  Y    KNF+RD     + C 
Sbjct: 280 TIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCD 339

Query: 584 CYEMQAQIYRTETSSTVH 601
            +  +   Y T   ST+H
Sbjct: 340 -FRSRDDDYETIAMSTMH 356


>gi|71999131 opsin 3 [Homo sapiens]
          Length = 402

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 37/315 (11%)

Query: 283 TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNL 342
           T SP P  F+P      Y  L +L+  I +L +  N++VLV+    Q   T    L+ N+
Sbjct: 29  TLSPAP-LFSPGT----YERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNI 83

Query: 343 AFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAIT 402
           + +DL + ++ +    V              W T  GC   GF       +S+ TLT + 
Sbjct: 84  SLSDLLVSLFGVTFTFVSCLRNGWV------WDT-VGCVWDGFSGSLFGIVSIATLTVLA 136

Query: 403 LERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDI-- 460
            ER+  + HA  ++     R    +    W+++ A A  P+ G + Y+     L   +  
Sbjct: 137 YERYIRVVHARVINFSWAWRAITYI----WLYSLAWAGAPLLGWNRYILDVHGLGCTVDW 192

Query: 461 ---DSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSS----------SSDTR 507
              D+  S   +   L   V+   VI  CY HI  ++R    V              + +
Sbjct: 193 KSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKK 252

Query: 508 IAKRMAMLIFTDFLCMAP---ISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLY 564
           +AK   ++IFT  +C  P   I F  ++    +   T+S   I+  LF   N+  NP +Y
Sbjct: 253 LAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTIS---IVSYLFAKSNTVYNPVIY 309

Query: 565 AIFTKNFRRDFFILL 579
               + FRR    LL
Sbjct: 310 VFMIRKFRRSLLQLL 324


>gi|4557859 somatostatin receptor 2 [Homo sapiens]
          Length = 369

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 71/328 (21%), Positives = 140/328 (42%), Gaps = 36/328 (10%)

Query: 267 TYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILT 326
           T+    +DL   VV    S + +   P  D+    +L  + + + I+ + GN +V+ ++ 
Sbjct: 13  TWLSIPFDLNGSVVSTNTSNQTE---PYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVIL 69

Query: 327 TSQYKLTVPRFLMCNLAFAD--LCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAA 383
                 T+    + NLA AD    +G+  L +    +H           W  G A C   
Sbjct: 70  RYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-----------WPFGKAICRVV 118

Query: 384 GFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGW---------IF 434
                     S++ LT ++++R+  + H ++     + R A  + +  W         I 
Sbjct: 119 MTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM 178

Query: 435 AFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTV 494
            +A      +G SS    +I  P +  +  +   + + ++  ++   +IC CY+ I + V
Sbjct: 179 IYAGLRSNQWGRSS---CTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV 235

Query: 495 RNPNI-VSSS----SDTRIAKRMAMLIFTDFLCMAPISFFAISA-SLKVPLITVSKAKI- 547
           ++  I V SS    S+ ++ + +++++     C  P   F +S+ S+ +      K    
Sbjct: 236 KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFD 295

Query: 548 LLVLFHPINSCANPFLYAIFTKNFRRDF 575
            +V+    NSCANP LYA  + NF++ F
Sbjct: 296 FVVVLTYANSCANPILYAFLSDNFKKSF 323


>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
          Length = 318

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/293 (22%), Positives = 130/293 (44%), Gaps = 32/293 (10%)

Query: 309 FISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYH 368
           FI + AI GN++V+ ++  +    T   + + +LA AD+ +G+ ++ +A V +      H
Sbjct: 21  FIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIV-VSLGITIH 79

Query: 369 NYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 428
            Y+  + T           +  +  S+ +L AI ++R+  +   ++       R     +
Sbjct: 80  FYSCLFMT--------CLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLAL 131

Query: 429 VMGWIFAFAAALFPIFG-----ISSYMKVSICLPMDIDSPLSQLYVM--SLLVLNVLAFV 481
            + W+ +F   L P+FG      S Y +    L     S +   Y++  S L    +  V
Sbjct: 132 GLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLV 191

Query: 482 VICGCYIHIYLTVRNPNI--VSSSSDT--------RIAKRMAMLIFTDFLCMAPISFF-- 529
           V+C  Y+ I+  +RN     +S+S +T        + AK + +++F   L   P+S    
Sbjct: 192 VMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINC 251

Query: 530 AISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKC 582
            I  + +VP + +     + +L    NS  NP +YA   K F+  + ++L  C
Sbjct: 252 IIYFNGEVPQLVL----YMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC 300


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 68/262 (25%), Positives = 115/262 (43%), Gaps = 55/262 (20%)

Query: 3   LLLVSLLAFLSLGSGCHHRICHCSNRV--FLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           +L  ++ A  S G      +C CSN+    +C    ++E+P  +P N   L  +   +++
Sbjct: 30  ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89

Query: 61  IQK------------------------GAFSGFGDLEKIEI------------------- 77
           IQ                         GAF+G   L  +E+                   
Sbjct: 90  IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149

Query: 78  ----SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIK 133
                +N+ +E I +  F+ +P L  + + +   L YI+  AF+ L NL+YL +    IK
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 209

Query: 134 HLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG- 192
            +P++  +  L++  L++  N +   I   SF GLS     LW+  + +  I   AF+G 
Sbjct: 210 DMPNLTPLVGLEE--LEMSGN-HFPEIRPGSFHGLS-SLKKLWVMNSQVSLIERNAFDGL 265

Query: 193 TQLDELNLSDNNNLEELPNDVF 214
             L ELNL+ +NNL  LP+D+F
Sbjct: 266 ASLVELNLA-HNNLSSLPHDLF 286


>gi|5174593 melatonin receptor 1A [Homo sapiens]
          Length = 350

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 62/314 (19%), Positives = 137/314 (43%), Gaps = 32/314 (10%)

Query: 303 LRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIH 362
           L  ++ F  ++ I GN++V++ +  ++         + +LA ADL + IY   +  + I 
Sbjct: 30  LACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIF 89

Query: 363 TKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQL 421
                      W  G   C  +GF    +   S++ +T I + R+  I H+++ D     
Sbjct: 90  NNG--------WNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSS 141

Query: 422 RHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLA-F 480
           +++   +++ W+   AA L P     +               +S  Y ++++V + L   
Sbjct: 142 KNSLCYVLLIWLLTLAAVL-PNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPM 200

Query: 481 VVICGCYIHIYLTV----------RNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
           +++  CY+ I++ V          R P +        +   +  ++F   +C AP++F  
Sbjct: 201 IIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFA--ICWAPLNFIG 258

Query: 531 ISASLKVPLITVSKAKILLVLFHPI---NSCANPFLYAIFTKNFRRDF-FILLSKCGCYE 586
           ++ +     +     + L V  + +   NSC N  +Y +  +NFR+++  I++S C    
Sbjct: 259 LAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLC---- 314

Query: 587 MQAQIYRTETSSTV 600
             A+++  ++S+ V
Sbjct: 315 -TARVFFVDSSNDV 327


>gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens]
          Length = 381

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 79/335 (23%), Positives = 143/335 (42%), Gaps = 35/335 (10%)

Query: 286 PKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFA 345
           P+P+  +  + I    +L +    I +L + GN +V+ ++   +   TV  F + NLA A
Sbjct: 36  PEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVA 95

Query: 346 DLCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLE 404
           DL +    L             +    +W+ G   C    +    A ++S  TLT I L+
Sbjct: 96  DLLVNTLCLPFTLT--------YTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALD 147

Query: 405 RWHTITHAMQLDCKVQLRHAASVMVMGW-IFAFAAALFPIFGISSYM------KVSICL- 456
           R   I +   L+ K+  R +  ++ + W I A  A+   IF   S +      ++  C  
Sbjct: 148 RHRCIVY--HLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTE 205

Query: 457 --PMDIDSPLSQLY-VMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSD------TR 507
             P +  S    +Y + SLL+L VL   +I   Y  I+  ++N     +++D       +
Sbjct: 206 KWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQK 265

Query: 508 IAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSC---ANPFLY 564
             K +  ++    +   P+  F ++  +   ++ + + K++  +FH I  C   ANP LY
Sbjct: 266 TTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLY 325

Query: 565 AIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSST 599
                N+R+ F   LS   C E +     +E S T
Sbjct: 326 GWMNSNYRKAF---LSAFRC-EQRLDAIHSEVSVT 356


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 55/243 (22%)

Query: 22  ICHCSNRV--FLCQESKVTEIPS---------DLPRNAIE---------------LRFVL 55
           +C CSN+    +C    + E+P          +L  N I+               L+   
Sbjct: 50  VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109

Query: 56  TKLRVIQKGAFSGFGDLEKIEIS-----------------------QNDVLEVIEADVFS 92
             +R I+ GAF+G  +L  +E+                        +N+ +E I +  F+
Sbjct: 110 NHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFN 169

Query: 93  NLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQ 152
            +P L  + + +   L YI+  AF+ L NL+YL ++   ++ +P++  +  L +  LD+ 
Sbjct: 170 RIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDE--LDLS 227

Query: 153 DNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPN 211
            N ++  I   SF GL      LW+ ++ IQ I   AF+  Q L E+NL+ +NNL  LP+
Sbjct: 228 GN-HLSAIRPGSFQGL-MHLQKLWMIQSQIQVIERNAFDNLQSLVEINLA-HNNLTLLPH 284

Query: 212 DVF 214
           D+F
Sbjct: 285 DLF 287


>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
          Length = 478

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 69/293 (23%), Positives = 118/293 (40%), Gaps = 30/293 (10%)

Query: 303 LRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIH 362
           L  +I  + +  + GN+ V+     S+   T     + NLA +D     +L+      + 
Sbjct: 73  LGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSD-----FLMSFTQAPVF 127

Query: 363 TKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLR 422
             S  +   +  +TG  C+   F        S+ TLTAI L+R+  IT  +        R
Sbjct: 128 FTSSLYKQWLFGETG--CEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKR 185

Query: 423 HAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDID----SPLSQLYVMSL-LVLNV 477
            AA V++  W++A A +L P FG S+Y+   +      D    +P  + Y M L   +  
Sbjct: 186 RAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFF 245

Query: 478 LAFVVICGCYIHIYLTVRNPNIVSSS------------------SDTRIAKRMAMLIFTD 519
           L  ++I  CYI I+  +R       +                  S+ ++AK M ++I   
Sbjct: 246 LPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLF 305

Query: 520 FLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFR 572
            L  AP S  A+ A      +       +  +    ++  NP +YAI    +R
Sbjct: 306 VLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 358


>gi|5921992 adenosine A2a receptor [Homo sapiens]
          Length = 412

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 79/350 (22%), Positives = 148/350 (42%), Gaps = 59/350 (16%)

Query: 297 IMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLI 356
           IMG ++   +   I++LAI GN++V   +  +     V  + + +LA AD+ +G+  +  
Sbjct: 3   IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI-- 60

Query: 357 ASVDIHTKSQYHNYAIDWQTGA-----GCDAAGFFTVFASELSVYTLTAITLERWHTITH 411
                        +AI   TG      GC     F +  ++ S+++L AI ++R+  I  
Sbjct: 61  ------------PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI 108

Query: 412 AMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVS--------------ICLP 457
            ++ +  V    A  ++ + W+ +FA  L P+ G ++  +                 CL 
Sbjct: 109 PLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLF 168

Query: 458 MDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRN----------PNIVSSSS--- 504
            D+  P++ +   +     ++  +++ G Y+ I+L  R           P   + S+   
Sbjct: 169 EDV-VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQK 227

Query: 505 DTRIAKRMAMLIFTDFLCMAPI------SFFAISASLKVPLITVSKAKILLVLFHPINSC 558
           +   AK +A+++    LC  P+      +FF    S   PL  +  A   +VL H  NS 
Sbjct: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCS-HAPLWLMYLA---IVLSH-TNSV 282

Query: 559 ANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNG 608
            NPF+YA   + FR+ F  ++ +      Q       TS+ V   H  +G
Sbjct: 283 VNPFIYAYRIREFRQTFRKII-RSHVLRQQEPFKAAGTSARVLAAHGSDG 331


>gi|4506527 rhodopsin [Homo sapiens]
          Length = 348

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 66/321 (20%), Positives = 132/321 (41%), Gaps = 37/321 (11%)

Query: 300 YNILRVLIWFISILAITGNIIVLVILTTSQYKLTVP-RFLMCNLAFADLCIGIYLLLIAS 358
           +++L   ++ + +L    N + L + T    KL  P  +++ NLA ADL      +++  
Sbjct: 37  FSMLAAYMFLLIVLGFPINFLTLYV-TVQHKKLRTPLNYILLNLAVADL-----FMVLGG 90

Query: 359 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 418
                 +  H Y +   TG  C+  GFF     E+++++L  + +ER+  +   M  + +
Sbjct: 91  FTSTLYTSLHGYFVFGPTG--CNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFR 147

Query: 419 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDID------SPLSQLYVMSL 472
               HA   +   W+ A A A  P+ G S Y+   +     ID         ++ +V+ +
Sbjct: 148 FGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYM 207

Query: 473 LVLN-VLAFVVICGCYIHIYLTVR------NPNIVSSSSDTRIAKRMAMLIFTDFLCMAP 525
            V++  +  ++I  CY  +  TV+        +  +  ++  + + + +++    +C  P
Sbjct: 208 FVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP 267

Query: 526 IS-----FFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILL- 579
            +      F    S   P+     A      F    +  NP +Y +  K FR      + 
Sbjct: 268 YASVAFYIFTHQGSNFGPIFMTIPA-----FFAKSAAIYNPVIYIMMNKQFRNCMLTTIC 322

Query: 580 ---SKCGCYEMQAQIYRTETS 597
              +  G  E  A + +TETS
Sbjct: 323 CGKNPLGDDEASATVSKTETS 343


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 64/242 (26%), Positives = 108/242 (44%), Gaps = 55/242 (22%)

Query: 23  CHCSNRV--FLCQESKVTEIPSDLP---------RNAIE---------------LRFVLT 56
           C CSN+    +C    + E+P+ +P          N I+               L+    
Sbjct: 61  CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120

Query: 57  KLRVIQKGAFSGFGDLEKIEIS-----------------------QNDVLEVIEADVFSN 93
            +R I+ GAF+G   L  +E+                        +N+ +E I +  F+ 
Sbjct: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180

Query: 94  LPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQD 153
           +P L  + + +   L YI+  AF+ L NL+YL +    +K +P++  +  L++  L++  
Sbjct: 181 VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE--LELSG 238

Query: 154 NINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPND 212
           N  +  I   SF GL+     LWL    +  I   AF+  + L+ELNLS +NNL  LP+D
Sbjct: 239 N-RLDLIRPGSFQGLT-SLRKLWLMHAQVATIERNAFDDLKSLEELNLS-HNNLMSLPHD 295

Query: 213 VF 214
           +F
Sbjct: 296 LF 297


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 13/148 (8%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CSN +  C+   +TEIP++LP    E+R     ++VI  GAFS +  L +I++S N +
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHL-----PD 137
            E +  D F  L  L+ + +   N +  +    F+ L +LQ LL++   I  L      D
Sbjct: 337 SE-LAPDAFQGLRSLNSL-VLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQD 394

Query: 138 VHKIHSLQKVLLDIQDNINIHTIERNSF 165
           +H ++     LL + DN  + TI + +F
Sbjct: 395 LHNLN-----LLSLYDN-KLQTIAKGTF 416



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 7/184 (3%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CS     C    +  +P ++PRN   L      +  I K  F+G   L  +++ +N +
Sbjct: 32  CSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKI 91

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPNLQYLLISNTGIKHLPDVHKI 141
              IE   F +L +L  +R+ +  N L + PE  F     L  L +S   I+ +P     
Sbjct: 92  -STIERGAFQDLKELERLRLNR--NHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFR 148

Query: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNL 200
            ++    L +  N  I  IE  +F  L  +  +L LN N I  +   +FN   +L    L
Sbjct: 149 GAVDIKNLQLDYN-QISCIEDGAFRALR-DLEVLTLNNNNITRLSVASFNHMPKLRTFRL 206

Query: 201 SDNN 204
             NN
Sbjct: 207 HSNN 210



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 4/144 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIEISQND 81
           C C      C   K+ +IP  +P+   ELR    +  V++  G F     L KI  S N 
Sbjct: 510 CRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNK 569

Query: 82  VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 141
           + + IE   F     ++EI +  +N L  +  + F+ L +L+ L++ +  I  + +   I
Sbjct: 570 ITD-IEEGAFEGASGVNEILL-TSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFI 627

Query: 142 HSLQKVLLDIQDNINIHTIERNSF 165
                 LL + DN  I T+   +F
Sbjct: 628 GLSSVRLLSLYDN-QITTVAPGAF 650



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C + V  C    +  +P  +PR+  EL     +  ++ K   S +  L  I++S N +
Sbjct: 731 CTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRI 789

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
              +    FSN+ +L  + I   N L  I P  F  L +L+ L +    I  +P+
Sbjct: 790 -STLSNQSFSNMTQLLTL-ILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842


>gi|23238240 angiotensin II receptor, type 2 [Homo sapiens]
          Length = 363

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 70/318 (22%), Positives = 132/318 (41%), Gaps = 39/318 (12%)

Query: 277 NEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPR 336
           N    + CS KP   +        + + +L + I ++    NI+V+ +    +    V  
Sbjct: 28  NNESTLNCSQKPSDKH-------LDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSS 80

Query: 337 FLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSV 395
             + NLA ADL      LL+A++ +   + Y++Y  DW  G   C   G F       S+
Sbjct: 81  IYIFNLAVADL------LLLATLPLW--ATYYSYRYDWLFGPVMCKVFGSFLTLNMFASI 132

Query: 396 YTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISS-----YM 450
           + +T ++++R+ ++ +   L  +     A+ ++ + W  A  ++L P F         Y+
Sbjct: 133 FFITCMSVDRYQSVIYPF-LSQRRNPWQASYIVPLVWCMACLSSL-PTFYFRDVRTIEYL 190

Query: 451 KVSICLPMDIDSPLSQLYVMSLLVLNVLAFVV----ICGCYIHIYLTVRNPNIVSSSSDT 506
            V+ C+        +Q      L+ N+L F++    I  CY  I   +   N    +  T
Sbjct: 191 GVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRIT 250

Query: 507 R--IAKRMAMLIFTDFLCMAP---------ISFFAISASLKVPLITVSKAKILLVLFHPI 555
           R  + K  A ++    +C  P         +++  +  S +V +  +  A    +L    
Sbjct: 251 RDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEV-IAVIDLALPFAILLGFT 309

Query: 556 NSCANPFLYAIFTKNFRR 573
           NSC NPFLY      F++
Sbjct: 310 NSCVNPFLYCFVGNRFQQ 327


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 47/147 (31%), Positives = 75/147 (51%), Gaps = 5/147 (3%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CSN +  C+   + EIP++LP   +E+R     ++ I  GAF+ +  L++I+IS+N +
Sbjct: 284 CTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQI 343

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH 142
            + I  D F  L  L  + +   N +  I    F  L +LQ LL++   I  L  V+   
Sbjct: 344 SD-IAPDAFQGLKSLTSL-VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL-RVNTFQ 400

Query: 143 SLQKV-LLDIQDNINIHTIERNSFVGL 168
            LQ + LL + DN  + TI +  F  L
Sbjct: 401 DLQNLNLLSLYDN-KLQTISKGLFAPL 426



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 55/175 (31%), Positives = 79/175 (45%), Gaps = 16/175 (9%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CS     C    +  +P  +PRNA  L      +  I K  F+G  +L  + +  N V
Sbjct: 38  CTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV 97

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPNLQYLLISNTGIKHLP----- 136
             VIE   F +L +L  +R+ K  N L + PE  FQ+ P L  L +S   I+ +P     
Sbjct: 98  -SVIERGAFQDLKQLERLRLNK--NKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFR 154

Query: 137 DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFN 191
            +  + +LQ       DN +I  IE  +F  L  +  IL LN N I  I   +FN
Sbjct: 155 GITDVKNLQ------LDNNHISCIEDGAFRALR-DLEILTLNNNNISRILVTSFN 202



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 42/153 (27%), Positives = 66/153 (43%), Gaps = 4/153 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIEISQND 81
           C C   +  C   K+  IPS LP    +LR    ++ V++  G F    +L KI +S N 
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNK 568

Query: 82  VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 141
           + EV E   F     + E+ +   N L  ++   F+ L  L+ L++ +  I  + +    
Sbjct: 569 IKEVREG-AFDGAASVQELML-TGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFA 626

Query: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVI 174
                 LL + DN  I TI   +F  L   S I
Sbjct: 627 GLSSVRLLSLYDN-RITTITPGAFTTLVSLSTI 658



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C   V  C    +  +P  +P++  EL      L  + +   S    L  I++S N +
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSI 787

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
             ++    FSN+  L  + I   N L  I   AF  L +L+ L +    I  +P+
Sbjct: 788 -SMLTNYTFSNMSHLSTL-ILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840


>gi|157426873 tachykinin receptor 2 [Homo sapiens]
          Length = 398

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 66/290 (22%), Positives = 117/290 (40%), Gaps = 28/290 (9%)

Query: 312 ILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYA 371
           ++A+TGN IV+ I+   +   TV  + + NLA ADLC+  +      V       Y ++ 
Sbjct: 45  LVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFV-------YASHN 97

Query: 372 IDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMG 431
           I +   A C     F + A  +S+Y++TAI  +R+  I H  Q   ++      +V+   
Sbjct: 98  IWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAGI 155

Query: 432 WIFAFAAALFPIFGISSYM-----KVSICLPMDIDSPLSQLY-VMSLLVLNVLAFVVICG 485
           W+ A A A    F  +  M     K  +  P D       LY ++ + ++  L   V+  
Sbjct: 156 WLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFV 215

Query: 486 CYIHIYLTV----------RNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASL 535
            Y  I LT+             N+    +  +  K M +++ T  +C  P   + I  S 
Sbjct: 216 AYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSF 275

Query: 536 KVPLIT---VSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKC 582
           +  +     + +  + L      ++  NP +Y      FR  F +    C
Sbjct: 276 QEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCC 325


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 7/158 (4%)

Query: 13  SLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDL 72
           +L SG    +C CSN +  C+   +T IP++LP    E+R  L  ++ I  GAFS +  L
Sbjct: 276 TLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335

Query: 73  EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
            +I++S N + E I  D F  L  L+ + +   N +  +    F  L  LQ LL++   I
Sbjct: 336 RRIDLSNNQIAE-IAPDAFQGLRSLNSL-VLYGNKITDLPRGVFGGLYTLQLLLLNANKI 393

Query: 133 KHL-PDVHKIHSLQKV-LLDIQDNINIHTIERNSFVGL 168
             + PD      LQ + LL + DN  I ++ + +F  L
Sbjct: 394 NCIRPDA--FQDLQNLSLLSLYDN-KIQSLAKGTFTSL 428



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 8/191 (4%)

Query: 3   LLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ 62
           L L+   A   LG+     +C C+     C  + +  IP ++PRN   L      +  I 
Sbjct: 18  LWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIH 77

Query: 63  KGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPN 121
           K  F+G   L  +++ +N +   +E   F ++ +L  +R+ +  N L++ PE  FQN   
Sbjct: 78  KNDFAGLKQLRVLQLMENQI-GAVERGAFDDMKELERLRLNR--NQLHMLPELLFQNNQA 134

Query: 122 LQYLLISNTGIKHLPDVHKIHSLQKVLLDIQ-DNINIHTIERNSFVGLSFESVILWLNKN 180
           L  L +S   I+ +P   K       L ++Q D   I  IE  +F  L    V L LN N
Sbjct: 135 LSRLDLSENAIQAIP--RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEV-LTLNNN 191

Query: 181 GIQEIHNCAFN 191
            I  I   +FN
Sbjct: 192 NITTIPVSSFN 202



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 7/150 (4%)

Query: 18  CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIE 76
           C H+ C C   V  C   K+T+IP  +P++  ELR    ++ +++  G F     L+KI 
Sbjct: 513 CPHK-CRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571

Query: 77  ISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP 136
           +S N V E IE   F     + E+ +  AN L  I    F+ L  L+ L++ N  I  + 
Sbjct: 572 LSNNKVSE-IEDGAFEGAASVSELHL-TANQLESIRSGMFRGLDGLRTLMLRNNRISCIH 629

Query: 137 DVHKIHSLQKV-LLDIQDNINIHTIERNSF 165
           +      L+ V LL + DN  I T+   +F
Sbjct: 630 N-DSFTGLRNVRLLSLYDN-QITTVSPGAF 657



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C + V  C    +  +P  +P+N  EL     +  ++  G  S F  L+ +++S N +
Sbjct: 738 CACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKI 796

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
             +  +  F+N+ +L  + I   N L  I P AFQ L +L+ L +    I  L +
Sbjct: 797 SSLSNSS-FTNMSQLTTL-ILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.138    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,777,696
Number of Sequences: 37866
Number of extensions: 910810
Number of successful extensions: 4689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 274
Number of HSP's successfully gapped in prelim test: 414
Number of HSP's that attempted gapping in prelim test: 3354
Number of HSP's gapped (non-prelim): 1096
length of query: 633
length of database: 18,247,518
effective HSP length: 108
effective length of query: 525
effective length of database: 14,157,990
effective search space: 7432944750
effective search space used: 7432944750
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.