Search of human proteins with 31542984

Search of human proteins with 31542984

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]
         (930 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]       1838   0.0  
gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [...   627   e-179
gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo ...   493   e-139
gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]       481   e-135
gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor ...   392   e-109
gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor...   390   e-108
gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]   369   e-102
gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor...   304   2e-82
gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...    70   1e-11
gi|194306644 BCSC-1 isoform 1 [Homo sapiens]                           67   6e-11
gi|38195080 BCSC-1 isoform 1 [Homo sapiens]                            67   6e-11
gi|218505703 von Willebrand factor A domain containing 3A [Homo ...    57   8e-08
gi|210147462 von Willebrand factor A domain containing 5B1 [Homo...    55   3e-07
gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subun...    52   2e-06
gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3 ...    52   3e-06
gi|38195082 BCSC-1 isoform 2 [Homo sapiens]                            50   7e-06
gi|118918435 von Willebrand factor A domain containing 3B [Homo ...    48   4e-05
gi|54112390 calcium channel, voltage-dependent, alpha 2/delta su...    47   8e-05
gi|54112394 calcium channel, voltage-dependent, alpha 2/delta su...    45   2e-04
gi|54112392 calcium channel, voltage-dependent, alpha 2/delta su...    45   2e-04
gi|224809466 anthrax toxin receptor 2 isoform 2 [Homo sapiens]         40   0.010
gi|50513243 anthrax toxin receptor 2 isoform 1 [Homo sapiens]          40   0.010
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]                38   0.038
gi|239753176 PREDICTED: similar to zinc finger protein 607 [Homo...    37   0.065
gi|239747750 PREDICTED: hypothetical protein XP_002348259 [Homo ...    37   0.065
gi|239741616 PREDICTED: hypothetical protein XP_002342249 [Homo ...    37   0.065
gi|239755891 PREDICTED: hypothetical protein [Homo sapiens]            37   0.085
gi|239755652 PREDICTED: hypothetical protein [Homo sapiens]            36   0.19 
gi|239750190 PREDICTED: hypothetical protein [Homo sapiens]            36   0.19 
gi|239744495 PREDICTED: hypothetical protein XP_002343166 [Homo ...    36   0.19 

>gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]
          Length = 930

 Score = 1838 bits (4760), Expect = 0.0
 Identities = 930/930 (100%), Positives = 930/930 (100%)

Query: 1   MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNR 60
           MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNR
Sbjct: 1   MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNR 60

Query: 61  ANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKA 120
           ANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKA
Sbjct: 61  ANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKA 120

Query: 121 TGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFE 180
           TGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFE
Sbjct: 121 TGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFE 180

Query: 181 PQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIR 240
           PQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIR
Sbjct: 181 PQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIR 240

Query: 241 YDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKI 300
           YDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKI
Sbjct: 241 YDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKI 300

Query: 301 LDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAV 360
           LDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAV
Sbjct: 301 LDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAV 360

Query: 361 QLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFD 420
           QLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFD
Sbjct: 361 QLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFD 420

Query: 421 VSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQN 480
           VSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQN
Sbjct: 421 VSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQN 480

Query: 481 NFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIF 540
           NFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIF
Sbjct: 481 NFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIF 540

Query: 541 HNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQE 600
           HNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQE
Sbjct: 541 HNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQE 600

Query: 601 QSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNF 660
           QSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNF
Sbjct: 601 QSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNF 660

Query: 661 RPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETT 720
           RPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETT
Sbjct: 661 RPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETT 720

Query: 721 MTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGF 780
           MTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGF
Sbjct: 721 MTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGF 780

Query: 781 SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP 840
           SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP
Sbjct: 781 SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP 840

Query: 841 DKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQ 900
           DKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQ
Sbjct: 841 DKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQ 900

Query: 901 GNDHSATRERRLDYQEGPPGVEISCWSVEL 930
           GNDHSATRERRLDYQEGPPGVEISCWSVEL
Sbjct: 901 GNDHSATRERRLDYQEGPPGVEISCWSVEL 930


>gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein
           [Homo sapiens]
          Length = 890

 Score =  627 bits (1616), Expect = e-179
 Identities = 312/582 (53%), Positives = 430/582 (73%), Gaps = 3/582 (0%)

Query: 31  NGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMT 90
           NGI++YS  ++S+V+SRFAH VVT R VNRA+T +E +F +ELPK AFITNF++ IDG+T
Sbjct: 41  NGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVT 100

Query: 91  YPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELL 150
           YPG +KEK  A+ QY  AV++GK+AGLVKA+GR +E+F VSV+VA  +K+TFEL YEELL
Sbjct: 101 YPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELL 160

Query: 151 KRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLV-DALTTWQNKT 209
           KR  G YE+ LKV+P+QLVKH ++++ IFEPQGIS L+ E++F+TN L+  ALT   +  
Sbjct: 161 KRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGK 220

Query: 210 KAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLT 269
           K H+ FKP+L QQ+  P   +++L+G+  I YDV+R  S G++QI NGYFVH+FAP+GL 
Sbjct: 221 KGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRE-SPGNVQIVNGYFVHFFAPQGLP 279

Query: 270 TMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPA 329
            +PKNV FVID SGSM+GRK++QT+EAL++IL+D+   D  N I+FS + + W+  LV A
Sbjct: 280 VVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQA 339

Query: 330 SAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPT 389
           + EN+ +AR+F   ++  G TNIND +L  + +L+ + +E R+PE S S++I+LTDGD  
Sbjct: 340 TPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDAN 399

Query: 390 VGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQ 449
           VGE+ P  IQ NVR A+ G++ L+ LGFG +++Y FLE +AL+N G ARRI+EDSD+ LQ
Sbjct: 400 VGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQ 459

Query: 450 LQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATV 509
           LQ FY+EVANPLLT V  EYP NA+ ++TQN ++  + GSE+VVAG+L D   +   A V
Sbjct: 460 LQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADV 519

Query: 510 SGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQ 569
            G   T ++TF  E  + E E   Q   YIF N++ERLWAYLTI+QLLE+  +A   +++
Sbjct: 520 KGHGATNDLTFTEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKE 579

Query: 570 ALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQ-VAEKPME 610
            L  +AL+LSL Y FVTPLTSMVVTKP+D E  + +A+KP E
Sbjct: 580 NLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGE 621



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 29/222 (13%)

Query: 732 PSAILPLPGQSVERLCVDPRHRQGPV-NLLSDPEQGVEVTGQYEREKAG----------F 780
           P  I+ +P +  + LC +     G V  L+ D   G+ V GQ   +K G          F
Sbjct: 652 PHFIIQIPEKD-DALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYF 710

Query: 781 SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP 840
             + +        V  + E + +      S + W +T+     GL M +++  +++ S  
Sbjct: 711 GKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVV-SFG 769

Query: 841 DKVTIGLLF---WDGRG---EGLRLLLRDTDRFSSHVGGTLGQFYQ-------EVLWGSP 887
           D VT  ++    W       + L   + D+ R S+   G LGQF+Q       ++  GS 
Sbjct: 770 DGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSD 829

Query: 888 AASDDGRRTLRVQGNDHSATRERRLDY-QEGPPGVEISCWSV 928
               D   TL V+ +    TR  + DY ++   G ++ CW V
Sbjct: 830 PTKPDA--TLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFV 869


>gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo
           sapiens]
          Length = 946

 Score =  493 bits (1268), Expect = e-139
 Identities = 311/922 (33%), Positives = 489/922 (53%), Gaps = 90/922 (9%)

Query: 29  EKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDG 88
           E + + +YS  V S ++SR A T++ S+VVN +   Q   F +++PK AFI+NFSM +DG
Sbjct: 66  EVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDG 125

Query: 89  MTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEE 148
            T+   IKEK   +A Y+ A AKGK+AGLV+++  +ME F+  V+V P AK+ FEL Y+E
Sbjct: 126 KTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQE 185

Query: 149 LLKRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNK 208
           +  R+LG YE  + ++P +L KHL++D+ + EPQG+ FL    TF            + +
Sbjct: 186 VKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTF-EGHFDGVPVISKGQ 244

Query: 209 TKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGL 268
            KAH+ FKPT++QQ+  P  +ET +DG L++ YDV R    G +++ NGYFVH+FAP+ L
Sbjct: 245 QKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNL 304

Query: 269 TTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVP 328
             +PKN++FVID SGSM G K++QT EA+  ILDDL   D F++I F+     WR  L+ 
Sbjct: 305 DPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLIS 364

Query: 329 ASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDP 388
           A+   V  A+ +   IQ  GGTNIN+A+L A+ +L+ +N    L   SVSLIIL++DGDP
Sbjct: 365 ATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDP 424

Query: 389 TVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSAL 448
           TVGE     IQ NV+E +    SLF LG GFDV Y FL++L+ +N G+A+RI+ + D++ 
Sbjct: 425 TVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSS 484

Query: 449 QLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTAT 508
           QL+ FY +V+ PLL  V F YP  +V +VTQNNF   F GSE+VVAGK      D + + 
Sbjct: 485 QLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESV 544

Query: 509 VSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLL-EQTVSASDAD 567
           ++       +  +T + + + +      K+   +F  +LWAYLTI QLL E++++ + A 
Sbjct: 545 ITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAA 604

Query: 568 QQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSGSTFFKY 627
           ++ +    L +SL +  VTPLTS+V+      E+  +A+ P +  S      SG+ ++  
Sbjct: 605 KRRITRSILQMSLDHHIVTPLTSLVIENEAGDER-MLADAPPQDPS----CCSGALYY-- 657

Query: 628 YLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPF 687
              G+K+                                        P   P  A   P 
Sbjct: 658 ---GSKVV---------------------------------------PDSTPSWANPSPT 675

Query: 688 RRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLC 747
             +++L   +    S P P V RV N                  P  I+ LP +S + +C
Sbjct: 676 PVISMLAQGSQVLESTPPPHVMRVEN-----------------DPHFIIYLP-KSQKNIC 717

Query: 748 VDPRHRQGPV-NLLSDPEQGVEVTGQYEREK--------AGFSWIEVTFKNPLVWVHASP 798
            +     G + NL+SDPE G+ V GQ    K          F  +   F++  + +  S 
Sbjct: 718 FNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEIST 777

Query: 799 EHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLF---WDGRG- 854
           E + ++    + +  W +T       +++++ K  ++ ++   +++  +L    W     
Sbjct: 778 ETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPV 837

Query: 855 --EGLRLLLRDTDRFSSHVGGTLGQFYQEV---LWGSPAASDDGR--RTLRVQGNDHSAT 907
             + L + +  T++FS    G +GQF QE    ++      D  +   ++ V+G     T
Sbjct: 838 NVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIIT 897

Query: 908 RERRLDYQEGPP-GVEISCWSV 928
           R  + DY+     G +++CW V
Sbjct: 898 RGLQKDYRTDLVFGTDVTCWFV 919


>gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]
          Length = 911

 Score =  481 bits (1238), Expect = e-135
 Identities = 272/658 (41%), Positives = 394/658 (59%), Gaps = 26/658 (3%)

Query: 4   PRPVRTCSKVLVLLSLLAI---------------HQTTTAEKNGIDIYSLTVDSRVSSRF 48
           PR +  C  ++ LL L A+                Q      +G+ I SL V+ +V+SRF
Sbjct: 7   PRGLLLCMYLVSLLILQAMPALGSATGRSKSSEKRQAVDTAVDGVFIRSLKVNCKVTSRF 66

Query: 49  AHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAA 108
           AH VVTS+VVN AN  +E  F +E+PK AFI++F++  DG  + G IK+K  A  QY  A
Sbjct: 67  AHYVVTSQVVNTANEAREVAFDLEIPKTAFISDFAVTADGNAFIGDIKDKVTAWKQYRKA 126

Query: 109 VAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQL 168
              G++AGLV+A+GR MEQF + ++V P +K+TF+L YEE+LKR    YE+++KV+P+QL
Sbjct: 127 AISGENAGLVRASGRTMEQFTIHLTVNPQSKVTFQLTYEEVLKRNHMQYEIVIKVKPKQL 186

Query: 169 VKHLQMDIHIFEPQGISFLETESTFMTNQLV-DALTTWQNKTKAHIRFKPTLSQQQKSPE 227
           V H ++D+ IFEPQGIS L+ +++F+  +L    +    +  K H+ F+PT+SQQQ  P 
Sbjct: 187 VHHFEIDVDIFEPQGISKLDAQASFLPKELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPT 246

Query: 228 QQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSG 287
              ++L+G+  + YDV R      + + N +F H+FAP+ LT M KNVVFVID SGSM G
Sbjct: 247 CSTSLLNGHFKVTYDVSRD-KICDLLVANNHFAHFFAPQNLTNMNKNVVFVIDISGSMRG 305

Query: 288 RKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQAL 347
           +K++QT+EAL+KIL D+ P D F+L++F T    W+ SLV AS  N+  A+ F  G    
Sbjct: 306 QKVKQTKEALLKILGDMQPGDYFDLVLFGTRVQSWKGSLVQASEANLQAAQDFVRGFSLD 365

Query: 348 GGTNINDAMLMAVQLLDSSNQEERLPEGS--VSLIILLTDGDPTVGETNPRSIQNNVREA 405
             TN+N  +L  +++L+    +E LPE S   S++I+LTDGDPT G T+   I  NVR A
Sbjct: 366 EATNLNGGLLRGIEILNQV--QESLPELSNHASILIMLTDGDPTEGVTDRSQILKNVRNA 423

Query: 406 VSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAV 465
           + GR+ L+ LGFG +V + FLE ++++N G A+RI+ED D+  QLQ FY +VA PLL  V
Sbjct: 424 IRGRFPLYNLGFGHNVDFNFLEVMSMENNGRAQRIYEDHDATQQLQGFYSQVAKPLLVDV 483

Query: 466 TFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESS 525
             +YP +AV  +TQN+ +  ++GSE+VVAG++ D       A V      Q  +      
Sbjct: 484 DLQYPQDAVLALTQNHHKQYYEGSEIVVAGRIADNKQSSFKADVQAHGEGQEFSITCLVD 543

Query: 526 VAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFV 585
             E +   +   ++  N +ERLWAYLTIQ+LL + +     ++  L +QAL +SL Y FV
Sbjct: 544 EEEMKKLLRERGHMLENHVERLWAYLTIQELLAKRMKVDREERANLSSQALQMSLDYGFV 603

Query: 586 TPLTSMVVTKPDDQE-QSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFS 642
           TPLTSM +    DQ+      +KP E       +    TF    LQ    P P  S S
Sbjct: 604 TPLTSMSIRGMADQDGLKPTIDKPSEDSPPLEMLGPRRTFVLSALQ----PSPTHSSS 657



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 54/221 (24%), Positives = 94/221 (42%), Gaps = 27/221 (12%)

Query: 732 PSAILPLPGQSVERLCVDPRHRQGPV-NLLSDPEQGVEVTGQYEREKA-------GFSWI 783
           P  I+ +P Q  + LC +     G + +L+ DP  G  V GQ    KA       G  + 
Sbjct: 673 PHFIIHVP-QKEDTLCFNINEEPGVILSLVQDPNTGFSVNGQLIGNKARSPGQHDGTYFG 731

Query: 784 EVTFKNPLV--WVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPD 841
            +   NP     +  +P+++ +        + W++       G+ +T++K   L++S  D
Sbjct: 732 RLGIANPATDFQLEVTPQNITLNPGFGGPVFSWRDQAVLRQDGVVVTINKKRNLVVSVDD 791

Query: 842 KVTIGLLF---WDGRG---EGLRLLLRDTDRFSSHVGGTLGQFYQEVLW-------GSPA 888
             T  ++    W G     + L   + D+ R S+   G LGQF+  + +       GS  
Sbjct: 792 GGTFEVVLHRVWKGSSVHQDFLGFYVLDSHRMSARTHGLLGQFFHPIGFEVSDIHPGSDP 851

Query: 889 ASDDGRRTLRVQGNDHSATRERRLDYQEGP-PGVEISCWSV 928
              D   T+ V+    + TR  + DY + P  G E+SCW +
Sbjct: 852 TKPDA--TMVVRNRRLTVTRGLQKDYSKDPWHGAEVSCWFI 890


>gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 3 [Homo sapiens]
          Length = 702

 Score =  392 bits (1007), Expect = e-109
 Identities = 248/647 (38%), Positives = 363/647 (56%), Gaps = 32/647 (4%)

Query: 39  TVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEK 98
           +V S + SR+A T V+ R++NRA+  Q+  FQM++P  AFITNF+M+I    Y G I E+
Sbjct: 55  SVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITER 114

Query: 99  AEAQAQYSAAVAKGKSAGLVKATG-RNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVY 157
            +     S    K K     +  G +  E F+ S  +    K  F L YEELL+RRLG Y
Sbjct: 115 EKK----SGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKY 170

Query: 158 ELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVD-----------ALTTWQ 206
           E  + VRPQQL   L +D++I E  GI+ LE      + Q              +    Q
Sbjct: 171 EHSISVRPQQLSGRLSVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQ 230

Query: 207 NKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPE 266
           N+T A+I FKPT+ QQ +    Q  +L G+ IIRYDV+R  S G IQ+ NGYFVHYFAP+
Sbjct: 231 NETFANIIFKPTVVQQARIA--QNGIL-GDFIIRYDVNREQSIGDIQVLNGYFVHYFAPK 287

Query: 267 GLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSL 326
            L  +PKNVVFV+D S SM G K++QT++AL  IL DL P+D+F++I FS     W+  L
Sbjct: 288 DLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHL 347

Query: 327 VPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDG 386
           +  + +++   + +   +   GGT+IN A+  A++LL+       + + SVSLI+ LTDG
Sbjct: 348 ISVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDG 407

Query: 387 DPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDS 446
            PTVGET+   I NN REA  G+  +F +G G DV +  LEKL+L+N GL RR+HE+ D+
Sbjct: 408 KPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDA 467

Query: 447 ALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLT 506
             QL  FY E+  PLL+ +  +YP ++V + T+  F   F GSE+++AGKL DR  D L 
Sbjct: 468 GSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLH 527

Query: 507 ATVSGKLPTQNITFQTESSVAEQEAEFQ---SPK-----YIFHNFMERLWAYLTIQQLLE 558
             V+     + I  +T+  V  Q+A      SP+         N +ERLW+YLT ++LL 
Sbjct: 528 VEVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLS 587

Query: 559 QTVSASD-ADQQALRNQALNLSLAYSFVTPLTSMVVTKP----DDQEQSQVAEKPMEGES 613
             + + D  +++ LR +A  L+++Y F+TP TSM +  P    D  E++      M  E 
Sbjct: 588 SWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEP 647

Query: 614 RNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNF 660
             ++V    T     L+    P+ + S +  RG+ R+     + M F
Sbjct: 648 VVQSVRGAGTQPGPLLKKPYQPRIKISKTSVRGFRREEQIFSNVMKF 694


>gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 1 [Homo sapiens]
          Length = 956

 Score =  390 bits (1003), Expect = e-108
 Identities = 245/635 (38%), Positives = 354/635 (55%), Gaps = 37/635 (5%)

Query: 39  TVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEK 98
           +V S + SR+A T V+ R++NRA+  Q+  FQM++P  AFITNF+M+I    Y G I E+
Sbjct: 55  SVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITER 114

Query: 99  AEAQAQYSAAVAKGKSAGLVKATG-RNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVY 157
            +     S    K K     +  G +  E F+ S  +    K  F L YEELL+RRLG Y
Sbjct: 115 EKK----SGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKY 170

Query: 158 ELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVD-----------ALTTWQ 206
           E  + VRPQQL   L +D++I E  GI+ LE      + Q              +    Q
Sbjct: 171 EHSISVRPQQLSGRLSVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQ 230

Query: 207 NKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPE 266
           N+T A+I FKPT+ QQ +    Q  +L G+ IIRYDV+R  S G IQ+ NGYFVHYFAP+
Sbjct: 231 NETFANIIFKPTVVQQARIA--QNGIL-GDFIIRYDVNREQSIGDIQVLNGYFVHYFAPK 287

Query: 267 GLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSL 326
            L  +PKNVVFV+D S SM G K++QT++AL  IL DL P+D+F++I FS     W+  L
Sbjct: 288 DLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHL 347

Query: 327 VPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDG 386
           +  + +++   + +   +   GGT+IN A+  A++LL+       + + SVSLI+ LTDG
Sbjct: 348 ISVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDG 407

Query: 387 DPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDS 446
            PTVGET+   I NN REA  G+  +F +G G DV +  LEKL+L+N GL RR+HE+ D+
Sbjct: 408 KPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDA 467

Query: 447 ALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLT 506
             QL  FY E+  PLL+ +  +YP ++V + T+  F   F GSE+++AGKL DR  D L 
Sbjct: 468 GSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLH 527

Query: 507 ATVSGKLPTQNITFQTESSVAEQEAEFQ---SPK-----YIFHNFMERLWAYLTIQQLLE 558
             V+     + I  +T+  V  Q+A      SP+         N +ERLW+YLT ++LL 
Sbjct: 528 VEVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLS 587

Query: 559 QTVSASD-ADQQALRNQALNLSLAYSFVTPLTSMVVTKP----DDQEQSQ-----VAEKP 608
             + + D  +++ LR +A  L+++Y F+TP TSM +  P    D  E++      +  +P
Sbjct: 588 SWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEP 647

Query: 609 MEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSP 643
           +    R      G    K Y    KI K      P
Sbjct: 648 VVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDP 682


>gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]
          Length = 1313

 Score =  369 bits (946), Expect = e-102
 Identities = 231/579 (39%), Positives = 330/579 (56%), Gaps = 23/579 (3%)

Query: 37  SLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIK 96
           S ++ S V SR+AHT+VTS + N      EA F ++LP  AFI+NF+M I+   Y   +K
Sbjct: 39  SYSMRSTVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVK 98

Query: 97  EKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGV 156
           EK +A+  Y  A  +GK+A  V    R  E+F++S S+A   ++TF L YEELL+R  G 
Sbjct: 99  EKHQAKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQ 158

Query: 157 YELLLKVRPQQLVKHLQMDIHIFEPQGISF----------LETESTFMTNQLVDALTTWQ 206
           Y+L++ +RP QLVK L +++ + E  GIS+          L T +         +    +
Sbjct: 159 YQLVVSLRPGQLVKRLSIEVTVSERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIER 218

Query: 207 NKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPE 266
            +T   I + PTL Q Q S      + D   +++YDV      G +QI + YF+HYFAP 
Sbjct: 219 GETCVRITYCPTL-QDQSSISGSGIMAD--FLVQYDVVMEDIIGDVQIYDDYFIHYFAPR 275

Query: 267 GLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRP-S 325
           GL  M KNVVFVID S SM G K++QT+ A+  IL DL   D FN+I FS     W+   
Sbjct: 276 GLPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWKAGG 335

Query: 326 LVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEE-RLPE-GSVSLIILL 383
            + A+ +NV+ A+ +   ++A G T++N A+L A  +L+ SNQE  R P  G + LII L
Sbjct: 336 SIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLIIFL 395

Query: 384 TDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHED 443
           TDG+PT G T P  I +NVR+A+  R SLF L FG D  +  L +L+L+N G+ARRI+ED
Sbjct: 396 TDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADFTLLRRLSLENRGIARRIYED 455

Query: 444 SDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPD 503
           +D+ALQL+  Y+E++ PLL  V   Y    V       F   F GSE+VVAG++Q  G  
Sbjct: 456 TDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFPNYFGGSELVVAGQVQP-GKQ 514

Query: 504 VLTATVSGKLPTQN--ITFQTESSVAEQEAEFQSPKYIFHN---FMERLWAYLTIQQLLE 558
            L   ++ + P     +   +E +    +  F  P     N   F+ RLWAY+TI +LL+
Sbjct: 515 ELGIHLAARGPKDQLLVAHHSEGATNNSQKAFGCPGEPAPNVAHFIRRLWAYVTIGELLD 574

Query: 559 QTVSASD-ADQQALRNQALNLSLAYSFVTPLTSMVVTKP 596
               A D   +  L  + LNLSL Y+FVTPLTS+V+ +P
Sbjct: 575 AHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLVMVQP 613


>gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 2 [Homo sapiens]
          Length = 742

 Score =  304 bits (779), Expect = 2e-82
 Identities = 181/456 (39%), Positives = 264/456 (57%), Gaps = 21/456 (4%)

Query: 206 QNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAP 265
           QN+T A+I FKPT+ QQ +    Q  +L G+ IIRYDV+R  S G IQ+ NGYFVHYFAP
Sbjct: 16  QNETFANIIFKPTVVQQARIA--QNGIL-GDFIIRYDVNREQSIGDIQVLNGYFVHYFAP 72

Query: 266 EGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPS 325
           + L  +PKNVVFV+D S SM G K++QT++AL  IL DL P+D+F++I FS     W+  
Sbjct: 73  KDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDH 132

Query: 326 LVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTD 385
           L+  + +++   + +   +   GGT+IN A+  A++LL+       + + SVSLI+ LTD
Sbjct: 133 LISVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTD 192

Query: 386 GDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSD 445
           G PTVGET+   I NN REA  G+  +F +G G DV +  LEKL+L+N GL RR+HE+ D
Sbjct: 193 GKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEED 252

Query: 446 SALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVL 505
           +  QL  FY E+  PLL+ +  +YP ++V + T+  F   F GSE+++AGKL DR  D L
Sbjct: 253 AGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHL 312

Query: 506 TATVSGKLPTQNITFQTESSVAEQEAEFQ---SPK-----YIFHNFMERLWAYLTIQQLL 557
              V+     + I  +T+  V  Q+A      SP+         N +ERLW+YLT ++LL
Sbjct: 313 HVEVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELL 372

Query: 558 EQTVSASD-ADQQALRNQALNLSLAYSFVTPLTSMVVTKP----DDQEQSQ-----VAEK 607
              + + D  +++ LR +A  L+++Y F+TP TSM +  P    D  E++      +  +
Sbjct: 373 SSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPE 432

Query: 608 PMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSP 643
           P+    R      G    K Y    KI K      P
Sbjct: 433 PVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDP 468


>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
            sapiens]
          Length = 1724

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 127/613 (20%), Positives = 237/613 (38%), Gaps = 60/613 (9%)

Query: 28   AEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIID 87
            A  N + +  + +  R+    A  +V     N+++   EA +   L  KA +  F   I+
Sbjct: 616  ASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFIN 675

Query: 88   GMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSV-SVAPNAKITFELVY 146
            G    G IKEK EAQ +Y  AV +G  A L+     ++  F VSV ++ P AK+  ++ Y
Sbjct: 676  GKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDV--FTVSVGNLPPKAKVLIKITY 733

Query: 147  --EELLKRRLGVYELLLKVRPQQLVKHLQMDIH-IFEPQGISFLETESTFMTNQLVDALT 203
              E  +   +GV+ +   V P Q  K L  ++    E   I  + T+ +F     ++   
Sbjct: 734  ITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEM-- 791

Query: 204  TWQNKTKAHIRFKPTLSQQQKSPEQQETV--LDGNLI--IRYDVDRAISGGSI------- 252
                       F  T   +QK  + +  +  ++G+ +    + +   +S   +       
Sbjct: 792  ----PYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK 847

Query: 253  --QIENGYFVHYFAPEGLTTMP-----KNVVFVIDKSGSMSGRKIQQTREALIKILDDLS 305
              + E+   +  F P+    +P       V+  +D S SM G    Q ++  +  L  + 
Sbjct: 848  HPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVG 907

Query: 306  PRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDS 365
             + + N+I F T   +   S       N   A    +    +G T+     L  + LL  
Sbjct: 908  EKQKVNIIQFGTGYKELF-SYPKHITSNTMAAEFIMSATPTMGNTDFWKT-LRYLSLL-- 963

Query: 366  SNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAF 425
                   P      I+L++D     G     S+   + +       LF  G G   +   
Sbjct: 964  ------YPARGSRNILLVSD-----GHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHV 1012

Query: 426  LEKLALDNGGLARRIHEDSDSA--LQLQDFYQEVANPLLTAVTFEYP--SNAVEEVTQNN 481
            L  L+    G+    +  S  +   Q++D    + +P   +V+ ++   +  V E  Q  
Sbjct: 1013 LRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAP 1072

Query: 482  FRL--LFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYI 539
             ++  LF    ++V G +    P    AT+   +  Q   F+T  S  E +   ++   +
Sbjct: 1073 AQVPSLFLNDRLLVYGFI----PHCTQATLCALI--QEKEFRTMVSTTELQ---KTTGTM 1123

Query: 540  FHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQ 599
             H    R         +L +  ++ +  +Q L++  + LS   S +T  TS V  +  D+
Sbjct: 1124 IHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDE 1183

Query: 600  EQSQVAEKPMEGE 612
             +S   + P   E
Sbjct: 1184 NESPFPDIPKVSE 1196


>gi|194306644 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 130/638 (20%), Positives = 251/638 (39%), Gaps = 84/638 (13%)

Query: 27  TAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMII 86
           T  +  + + S++V   +    A    T    N      EA F   + + + + +F  ++
Sbjct: 9   TLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALV 68

Query: 87  DGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSV-SVAPNAKITFELV 145
           DG      +++K +A+  Y  A+++G  A L++    + + F  +V ++ P +K    L 
Sbjct: 69  DGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLK 128

Query: 146 Y-EELLKRRLGVYELLLK--VRPQQLVKHLQMD--IHIFEPQGISFLETESTFMTNQLVD 200
           Y +EL     G    +L   + P+        D  +++  P     +  E    T  +V 
Sbjct: 129 YVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTP----IVPVEDLPYTLSMVA 184

Query: 201 ALTTWQN--KTKAHIRFKPTLSQQQKSPEQQETVLDGN-------LIIRYDVDRA----I 247
            + +     K +++    PT    +     Q ++  G+       L+I Y+        +
Sbjct: 185 TIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTPSVVL 244

Query: 248 SGGSIQIENGYFVH------YFAPEGLTTMPKNV----VFVIDKSGSM---------SGR 288
             G   ++ G+ +        F P      P N     +F++D+SGSM         S  
Sbjct: 245 EMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQL 304

Query: 289 KIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQA-L 347
           +IQ  +E LI +L  L     FN+  F +      P  V  + + + +A      +QA L
Sbjct: 305 RIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADL 364

Query: 348 GGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVS 407
           GGT I       +  L +  +   +P   + L +  TDG+ T   +  + ++ N +    
Sbjct: 365 GGTEI-------LAPLQNIYRGPSIPGHPLQLFV-FTDGEVTDTFSVIKEVRINRQ---- 412

Query: 408 GRYSLFCLGFGFDVSYAFLEKLALDNGGLARRI----HEDSDSALQLQDFYQEVANPLLT 463
            ++  F  G G   S + ++ +A  +GG +  I       S +   L+   Q V   +  
Sbjct: 413 -KHRCFSFGIGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDV-- 469

Query: 464 AVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDV-LTATVSGKLPTQNITFQT 522
           ++++  P     ++      ++F+G  ++   +L  R P    T  V  K   Q  TF+ 
Sbjct: 470 SLSWHLPPGLSAKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFED 529

Query: 523 ESSVAEQEAEFQSPKYIFHNFMERLWA--YLTIQQLLEQTVSASDADQQALRNQALNLSL 580
           + +   Q      PK   +  + RL A   L  + +  +   ASD      +  ALNLSL
Sbjct: 530 KVTFPLQ------PKPDVNLTIHRLAAKSLLQTKDMGLRETPASD------KKDALNLSL 577

Query: 581 AYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNV 618
               ++  T+ +    +         KP++G   +R+V
Sbjct: 578 ESGVISSFTAFIAINKE-------LNKPVQGPLAHRDV 608


>gi|38195080 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 130/638 (20%), Positives = 251/638 (39%), Gaps = 84/638 (13%)

Query: 27  TAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMII 86
           T  +  + + S++V   +    A    T    N      EA F   + + + + +F  ++
Sbjct: 9   TLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALV 68

Query: 87  DGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSV-SVAPNAKITFELV 145
           DG      +++K +A+  Y  A+++G  A L++    + + F  +V ++ P +K    L 
Sbjct: 69  DGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLK 128

Query: 146 Y-EELLKRRLGVYELLLK--VRPQQLVKHLQMD--IHIFEPQGISFLETESTFMTNQLVD 200
           Y +EL     G    +L   + P+        D  +++  P     +  E    T  +V 
Sbjct: 129 YVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTP----IVPVEDLPYTLSMVA 184

Query: 201 ALTTWQN--KTKAHIRFKPTLSQQQKSPEQQETVLDGN-------LIIRYDVDRA----I 247
            + +     K +++    PT    +     Q ++  G+       L+I Y+        +
Sbjct: 185 TIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTPSVVL 244

Query: 248 SGGSIQIENGYFVH------YFAPEGLTTMPKNV----VFVIDKSGSM---------SGR 288
             G   ++ G+ +        F P      P N     +F++D+SGSM         S  
Sbjct: 245 EMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQL 304

Query: 289 KIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQA-L 347
           +IQ  +E LI +L  L     FN+  F +      P  V  + + + +A      +QA L
Sbjct: 305 RIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADL 364

Query: 348 GGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVS 407
           GGT I       +  L +  +   +P   + L +  TDG+ T   +  + ++ N +    
Sbjct: 365 GGTEI-------LAPLQNIYRGPSIPGHPLQLFV-FTDGEVTDTFSVIKEVRINRQ---- 412

Query: 408 GRYSLFCLGFGFDVSYAFLEKLALDNGGLARRI----HEDSDSALQLQDFYQEVANPLLT 463
            ++  F  G G   S + ++ +A  +GG +  I       S +   L+   Q V   +  
Sbjct: 413 -KHRCFSFGIGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDV-- 469

Query: 464 AVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDV-LTATVSGKLPTQNITFQT 522
           ++++  P     ++      ++F+G  ++   +L  R P    T  V  K   Q  TF+ 
Sbjct: 470 SLSWHLPPGLSAKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFED 529

Query: 523 ESSVAEQEAEFQSPKYIFHNFMERLWA--YLTIQQLLEQTVSASDADQQALRNQALNLSL 580
           + +   Q      PK   +  + RL A   L  + +  +   ASD      +  ALNLSL
Sbjct: 530 KVTFPLQ------PKPDVNLTIHRLAAKSLLQTKDMGLRETPASD------KKDALNLSL 577

Query: 581 AYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNV 618
               ++  T+ +    +         KP++G   +R+V
Sbjct: 578 ESGVISSFTAFIAINKE-------LNKPVQGPLAHRDV 608


>gi|218505703 von Willebrand factor A domain containing 3A [Homo
           sapiens]
          Length = 1184

 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 5/120 (4%)

Query: 269 TTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVP 328
           T   K VV ++D S + S   I       + + + LS +D FNLI F +    WRP +VP
Sbjct: 506 TVCEKRVVVLLDISATNSMYIIHIQHSLRLLLEEQLSNKDCFNLIAFGSTIESWRPEMVP 565

Query: 329 ASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDP 388
            S  N+  A  +A  ++  G  N+  A+  AV+ +D  ++++   +G    I L T G P
Sbjct: 566 VSHNNLQSAWRWALNLRCRGSRNVLSALRKAVE-VDFKDKDKHQSQG----IYLFTGGIP 620



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 15/169 (8%)

Query: 269  TTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPR--DQFNLIVFSTEATQWRPSL 326
            T +   V  ++D SGSM G  +QQ +  L+ ++ +   +  D FNL+ F+     W+ +L
Sbjct: 954  TVLESKVCILLDTSGSM-GPYLQQVKTELVLLIWEQLRKCCDSFNLLSFAESFQSWQDTL 1012

Query: 327  VPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDG 386
            V  +    ++A  +   +QA G T+I  A+L A    D               + LLTDG
Sbjct: 1013 VETTDAACHEAMQWVTHLQAQGSTSILQALLKAFSFHDLEG------------LYLLTDG 1060

Query: 387  DPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGG 435
             P    +   +    +RE    +     L      +  FL KLA   GG
Sbjct: 1061 KPDTSCSLVLNEVQKLREKRDVKVHTISLNCSDRAAVEFLRKLASFTGG 1109



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 36/155 (23%), Positives = 70/155 (45%), Gaps = 16/155 (10%)

Query: 275 VVFVIDKSGSMSGRKIQQTREALIKILDD-LSPRDQFNLIVFSTEATQWRPSLVPASAEN 333
           V  +ID S   SG + ++ ++ L+ ++D+ LS +++  ++ F T A    P  +  SA  
Sbjct: 171 VSILIDVSAISSGPQKEEFQKDLMSLIDEQLSHKEKLFVLSFGTNAGSLWPDPMEVSAST 230

Query: 334 VNKARSFAAGIQALGGTNINDAM--LMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVG 391
           + + + +   +Q  GG+N+  A+  +  ++ LDS     R      S I+       T+G
Sbjct: 231 LQELKLWVKTLQPDGGSNLLQALKKIFTLKGLDSLVAIMRSCPDQPSEILSDYIQQSTMG 290

Query: 392 -------------ETNPRSIQNNVREAVSGRYSLF 413
                        +  P ++  N+ EAV G Y  +
Sbjct: 291 RDLIIHFITYRCDDQMPPAVLKNLAEAVRGYYHCY 325


>gi|210147462 von Willebrand factor A domain containing 5B1 [Homo
           sapiens]
          Length = 1215

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 58/228 (25%), Positives = 102/228 (44%), Gaps = 18/228 (7%)

Query: 276 VFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVN 335
           +F+ID+S SMSG  + + ++A++  L  L P   FN+I F +      PS    S +++ 
Sbjct: 363 IFLIDRSSSMSGISMHRVKDAMLVALKSLMPACLFNIIGFGSTFKSLFPSSQTYSEDSLA 422

Query: 336 KARSFAAGIQA-LGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETN 394
            A      ++A +GGTNI   +   ++        + +  G   L+ ++TDG       N
Sbjct: 423 MACDDIQRMKADMGGTNILSPLKWVIR--------QPVHRGHPRLLFVITDG----AVNN 470

Query: 395 PRSIQNNVR-EAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDF 453
              +   VR  A S R   +  G G +V +  ++ LA  + G A  + E      ++   
Sbjct: 471 TGKVLELVRNHAFSTR--CYSFGIGPNVCHRLVKGLASVSEGSAELLMEGERLQPKMVKS 528

Query: 454 YQEVANPLLTAVTFE--YPSNAVEEVTQNNFRLLFKGSEMVVAGKLQD 499
            ++   P+L+ VT E  +P      V+  +   LF G  +V  G + D
Sbjct: 529 LKKAMAPVLSDVTVEWIFPETTEVLVSPVSASSLFPGERLVGYGIVCD 576


>gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subunit
           [Homo sapiens]
          Length = 1137

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 49/200 (24%), Positives = 92/200 (46%), Gaps = 15/200 (7%)

Query: 270 TMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPS---- 325
           T PK++V ++D SGSM G ++   +  +  ILD L   D  N+I ++       P     
Sbjct: 287 TSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGI 346

Query: 326 LVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSV--SLIILL 383
           LV A  +N    +     +   G   ++ A+  A Q+L    Q +   +GS+    I+L+
Sbjct: 347 LVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQIL---KQFQEAKQGSLCNQAIMLI 403

Query: 384 TDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEK-LALDNGGLARRIHE 442
           +DG   V +  P   + N  +    +  +F    G +VS+A   K +A +N G   +I  
Sbjct: 404 SDG--AVEDYEPVFEKYNWPDC---KVRVFTYLIGREVSFADRMKWIACNNKGYYTQIST 458

Query: 443 DSDSALQLQDFYQEVANPLL 462
            +D+   + ++   ++ P++
Sbjct: 459 LADTQENVMEYLHVLSRPMV 478


>gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3
           subunit [Homo sapiens]
          Length = 1091

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 9/123 (7%)

Query: 270 TMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRP----S 325
           T PK+VV ++D SGSM G ++   ++ +  ILD L   D FN+I ++ E     P    +
Sbjct: 252 TSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGT 311

Query: 326 LVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSV--SLIILL 383
           LV A   N    R     + A G   ++ A+  A  +L   N      +GS+    I+L+
Sbjct: 312 LVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFN---HTGQGSICSQAIMLI 368

Query: 384 TDG 386
           TDG
Sbjct: 369 TDG 371


>gi|38195082 BCSC-1 isoform 2 [Homo sapiens]
          Length = 415

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 76/365 (20%), Positives = 144/365 (39%), Gaps = 43/365 (11%)

Query: 27  TAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMII 86
           T  +  + + S++V   +    A    T    N      EA F   + + + + +F  ++
Sbjct: 9   TLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALV 68

Query: 87  DGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSV-SVAPNAKITFELV 145
           DG      +++K +A+  Y  A+++G  A L++    + + F  +V ++ P +K    L 
Sbjct: 69  DGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLK 128

Query: 146 Y-EELLKRRLGVYELLLK--VRPQQLVKHLQMD--IHIFEPQGISFLETESTFMTNQLVD 200
           Y +EL     G    +L   + P+        D  +++  P     +  E    T  +V 
Sbjct: 129 YVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTP----IVPVEDLPYTLSMVA 184

Query: 201 ALTTWQN--KTKAHIRFKPTLSQQQKSPEQQETVLDGN-------LIIRYDVDRA----I 247
            + +     K +++    PT    +     Q ++  G+       L+I Y+        +
Sbjct: 185 TIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTPSVVL 244

Query: 248 SGGSIQIENGYFVH------YFAPEGLTTMPKNV----VFVIDKSGSM---------SGR 288
             G   ++ G+ +        F P      P N     +F++D+SGSM         S  
Sbjct: 245 EMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQL 304

Query: 289 KIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQA-L 347
           +IQ  +E LI +L  L     FN+  F +      P  V  + + + +A      +QA L
Sbjct: 305 RIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADL 364

Query: 348 GGTNI 352
           GGT I
Sbjct: 365 GGTEI 369


>gi|118918435 von Willebrand factor A domain containing 3B [Homo
           sapiens]
          Length = 1294

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 37/162 (22%), Positives = 71/162 (43%), Gaps = 17/162 (10%)

Query: 275 VVFVIDKSGSMSGRKIQQTREALIKILDD-LSPRDQFNLIVFSTEATQWRPSLVPASAEN 333
           +  +ID S SM   K+   ++ +I+ + + L  + +FN + F  +A  WR  L   + +N
Sbjct: 509 IYILIDTSHSMKS-KLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDN 567

Query: 334 VNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGET 393
           + +A+S+   I+    TN   A+  A              +     I LLTDG P   + 
Sbjct: 568 LEQAQSWIRDIKIGSSTNTLSALKTA------------FADKETQAIYLLTDGRP---DQ 612

Query: 394 NPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGG 435
            P ++ + V+             +  +++  FL+++A   GG
Sbjct: 613 PPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGG 654



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 19/67 (28%), Positives = 37/67 (55%), Gaps = 2/67 (2%)

Query: 275 VVFVIDKSGSMSGRKIQQTREALIKILDD-LSPRDQFNLIVFSTEATQWRPSLVPASAEN 333
           V  V+D  G + G ++   REAL  +L + ++   +FN+I  S E  +W+ +  P + ++
Sbjct: 142 VTIVLDFGGILEG-ELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQS 200

Query: 334 VNKARSF 340
           +  A S+
Sbjct: 201 IATAISW 207


>gi|54112390 calcium channel, voltage-dependent, alpha 2/delta
           subunit 1 [Homo sapiens]
          Length = 1091

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 46/195 (23%), Positives = 83/195 (42%), Gaps = 10/195 (5%)

Query: 272 PKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEA--TQWRPSLVPA 329
           PK+++ ++D SGS+SG  ++  R ++ ++L+ LS  D  N+  F++ A        LV A
Sbjct: 251 PKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQA 310

Query: 330 SAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPT 389
           +  N    +     I A G T+       A + L + N           +I+L TDG   
Sbjct: 311 NVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR---ANCNKIIMLFTDG--- 364

Query: 390 VGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQ 449
            GE   + I N   +    R   F +G   +     ++ +A +N G    I       + 
Sbjct: 365 -GEERAQEIFNKYNKDKKVRVFTFSVG-QHNYDRGPIQWMACENKGYYYEIPSIGAIRIN 422

Query: 450 LQDFYQEVANPLLTA 464
            Q++   +  P++ A
Sbjct: 423 TQEYLDVLGRPMVLA 437


>gi|54112394 calcium channel, voltage-dependent, alpha 2/delta
           subunit 2 isoform b [Homo sapiens]
          Length = 1143

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 272 PKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEA--TQWRPSLVPA 329
           PK++V ++D SGS+SG  ++  + ++ ++LD LS  D  N+  F+ +A        LV A
Sbjct: 289 PKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQA 348

Query: 330 SAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDG 386
           +  N    +    G+ A G T        A   L +SN           +I++ TDG
Sbjct: 349 NVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR---ANCNKMIMMFTDG 402


>gi|54112392 calcium channel, voltage-dependent, alpha 2/delta
           subunit 2 isoform a [Homo sapiens]
          Length = 1145

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 272 PKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEA--TQWRPSLVPA 329
           PK++V ++D SGS+SG  ++  + ++ ++LD LS  D  N+  F+ +A        LV A
Sbjct: 289 PKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQA 348

Query: 330 SAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDG 386
           +  N    +    G+ A G T        A   L +SN           +I++ TDG
Sbjct: 349 NVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR---ANCNKMIMMFTDG 402


>gi|224809466 anthrax toxin receptor 2 isoform 2 [Homo sapiens]
          Length = 489

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 42/163 (25%), Positives = 76/163 (46%), Gaps = 22/163 (13%)

Query: 274 NVVFVIDKSGSMSGRKI------QQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLV 327
           ++ FV+DKSGS++   I      QQ  E  +      SP  + + IVFS++AT   P  +
Sbjct: 44  DLYFVLDKSGSVANNWIEIYNFVQQLAERFV------SPEMRLSFIVFSSQATIILP--L 95

Query: 328 PASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGD 387
                 ++K       +  +G T I++ + +A + +  +   +     + S+II LTDG 
Sbjct: 96  TGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLK-----TSSIIIALTDG- 149

Query: 388 PTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLA 430
             +    P   +   + + S   S++C+G   D   A LE++A
Sbjct: 150 -KLDGLVPSYAEKEAKISRSLGASVYCVGV-LDFEQAQLERIA 190


>gi|50513243 anthrax toxin receptor 2 isoform 1 [Homo sapiens]
          Length = 488

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 42/163 (25%), Positives = 76/163 (46%), Gaps = 22/163 (13%)

Query: 274 NVVFVIDKSGSMSGRKI------QQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLV 327
           ++ FV+DKSGS++   I      QQ  E  +      SP  + + IVFS++AT   P  +
Sbjct: 44  DLYFVLDKSGSVANNWIEIYNFVQQLAERFV------SPEMRLSFIVFSSQATIILP--L 95

Query: 328 PASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGD 387
                 ++K       +  +G T I++ + +A + +  +   +     + S+II LTDG 
Sbjct: 96  TGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLK-----TSSIIIALTDG- 149

Query: 388 PTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLA 430
             +    P   +   + + S   S++C+G   D   A LE++A
Sbjct: 150 -KLDGLVPSYAEKEAKISRSLGASVYCVGV-LDFEQAQLERIA 190


>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
          Length = 690

 Score = 38.1 bits (87), Expect = 0.038
 Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 20/89 (22%)

Query: 652 GAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRV 711
           G  G R+   P +L    LG PGPP++ D           +LP+ +PP+ S P P     
Sbjct: 590 GEFGGRVGVFPSLLVEELLGPPGPPELSDPE--------QMLPSPSPPSFSPPAP----- 636

Query: 712 MNMKIEETTMTTQTPAPIQAPSAILPLPG 740
                  T++    PAP+      L  PG
Sbjct: 637 -------TSVLDGPPAPVLPGDKALDFPG 658


>gi|239753176 PREDICTED: similar to zinc finger protein 607 [Homo
           sapiens]
          Length = 197

 Score = 37.4 bits (85), Expect = 0.065
 Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 11/66 (16%)

Query: 637 PEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPAS 696
           PE S SP +G +R   AA +         S  +  +P PP  P HA   P +R    P+S
Sbjct: 138 PETSGSPEKGVSRHGSAAAA---------SLPRAQVPTPP--PSHAQPQPLQRTPQSPSS 186

Query: 697 APPATS 702
           +PPA S
Sbjct: 187 SPPAAS 192


>gi|239747750 PREDICTED: hypothetical protein XP_002348259 [Homo
           sapiens]
          Length = 197

 Score = 37.4 bits (85), Expect = 0.065
 Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 11/66 (16%)

Query: 637 PEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPAS 696
           PE S SP +G +R   AA +         S  +  +P PP  P HA   P +R    P+S
Sbjct: 138 PETSGSPEKGVSRHGSAAAA---------SLPRAQVPTPP--PSHAQPQPLQRTPQSPSS 186

Query: 697 APPATS 702
           +PPA S
Sbjct: 187 SPPAAS 192


>gi|239741616 PREDICTED: hypothetical protein XP_002342249 [Homo
           sapiens]
          Length = 197

 Score = 37.4 bits (85), Expect = 0.065
 Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 11/66 (16%)

Query: 637 PEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPAS 696
           PE S SP +G +R   AA +         S  +  +P PP  P HA   P +R    P+S
Sbjct: 138 PETSGSPEKGVSRHGSAAAA---------SLPRAQVPTPP--PSHAQPQPLQRTPQSPSS 186

Query: 697 APPATS 702
           +PPA S
Sbjct: 187 SPPAAS 192


>gi|239755891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 246

 Score = 37.0 bits (84), Expect = 0.085
 Identities = 29/79 (36%), Positives = 34/79 (43%), Gaps = 5/79 (6%)

Query: 631 GAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRL 690
           G        S +PRRGW +QA   G     R G+   R+  L  P   P  A      RL
Sbjct: 104 GPSAQPSRGSETPRRGWRKQAATLGRGAEPRFGLSLPRRSELRKPR--PSAAPRRTRPRL 161

Query: 691 AILPASAPPATSNPDPAVS 709
           A LP SAP A   P PA +
Sbjct: 162 AALPVSAPLA---PRPAAA 177


>gi|239755652 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 158

 Score = 35.8 bits (81), Expect = 0.19
 Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 16/68 (23%)

Query: 649 RQAGAAGSRMNFRPGVLS-SRQL-----------GLPGPPDVPDHAAYHPFRRLAILPAS 696
           R  G  GSR++ RPGV S SRQL           G    PD P   A  P    A+LP  
Sbjct: 63  RPGGPRGSRLSSRPGVPSRSRQLTPPPGSPMASFGALATPDPPVGGAPAP----ALLPGQ 118

Query: 697 APPATSNP 704
           APPA  +P
Sbjct: 119 APPALPSP 126


>gi|239750190 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 158

 Score = 35.8 bits (81), Expect = 0.19
 Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 16/68 (23%)

Query: 649 RQAGAAGSRMNFRPGVLS-SRQL-----------GLPGPPDVPDHAAYHPFRRLAILPAS 696
           R  G  GSR++ RPGV S SRQL           G    PD P   A  P    A+LP  
Sbjct: 63  RPGGPRGSRLSSRPGVPSRSRQLTPPPGSPMASFGALATPDPPVGGAPAP----ALLPGQ 118

Query: 697 APPATSNP 704
           APPA  +P
Sbjct: 119 APPALPSP 126


>gi|239744495 PREDICTED: hypothetical protein XP_002343166 [Homo
           sapiens]
          Length = 158

 Score = 35.8 bits (81), Expect = 0.19
 Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 16/68 (23%)

Query: 649 RQAGAAGSRMNFRPGVLS-SRQL-----------GLPGPPDVPDHAAYHPFRRLAILPAS 696
           R  G  GSR++ RPGV S SRQL           G    PD P   A  P    A+LP  
Sbjct: 63  RPGGPRGSRLSSRPGVPSRSRQLTPPPGSPMASFGALATPDPPVGGAPAP----ALLPGQ 118

Query: 697 APPATSNP 704
           APPA  +P
Sbjct: 119 APPALPSP 126


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,121,714
Number of Sequences: 37866
Number of extensions: 1644230
Number of successful extensions: 5432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 5328
Number of HSP's gapped (non-prelim): 119
length of query: 930
length of database: 18,247,518
effective HSP length: 112
effective length of query: 818
effective length of database: 14,006,526
effective search space: 11457338268
effective search space used: 11457338268
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.