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Search of human proteins with 31542244
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
(719 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542244 leucine rich repeat and fibronectin type III domain ... 1435 0.0
gi|55741571 leucine rich repeat and fibronectin type III domain ... 699 0.0
gi|149773484 leucine rich repeat and fibronectin type III domain... 678 0.0
gi|13375646 leucine rich repeat and fibronectin type III domain ... 592 e-169
gi|27363458 leucine rich repeat and fibronectin type III domain ... 572 e-163
gi|51317373 netrin-G1 ligand [Homo sapiens] 164 3e-40
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 155 9e-38
gi|109150416 peroxidasin [Homo sapiens] 147 3e-35
gi|126517478 peroxidasin homolog-like [Homo sapiens] 145 2e-34
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 142 1e-33
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 141 2e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 141 2e-33
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 138 2e-32
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 132 1e-30
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 132 1e-30
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 129 7e-30
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 129 7e-30
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 129 7e-30
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 127 5e-29
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 122 9e-28
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 120 6e-27
gi|11321571 slit homolog 3 [Homo sapiens] 106 7e-23
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 106 7e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 106 7e-23
gi|4759146 slit homolog 2 [Homo sapiens] 106 9e-23
gi|153791466 AMIGO protein [Homo sapiens] 105 1e-22
gi|62988340 leucine rich repeat containing 22 [Homo sapiens] 104 3e-22
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 103 7e-22
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 102 1e-21
gi|198041768 synleurin [Homo sapiens] 102 2e-21
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 1435 bits (3714), Expect = 0.0
Identities = 719/719 (100%), Positives = 719/719 (100%)
Query: 1 MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLAD 60
MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLAD
Sbjct: 1 MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLAD 60
Query: 61 NFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS 120
NFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS
Sbjct: 61 NFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS 120
Query: 121 GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDH 180
GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDH
Sbjct: 121 GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDH 180
Query: 181 NMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN 240
NMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN
Sbjct: 181 NMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN 240
Query: 241 PLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE 300
PLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE
Sbjct: 241 PLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE 300
Query: 301 GQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIAS 360
GQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIAS
Sbjct: 301 GQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIAS 360
Query: 361 NPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK 420
NPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK
Sbjct: 361 NPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK 420
Query: 421 IVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGT 480
IVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGT
Sbjct: 421 IVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGT 480
Query: 481 MYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVAS 540
MYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVAS
Sbjct: 481 MYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVAS 540
Query: 541 VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENA 600
VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENA
Sbjct: 541 VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENA 600
Query: 601 QCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAV 660
QCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAV
Sbjct: 601 QCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAV 660
Query: 661 TNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI 719
TNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI
Sbjct: 661 TNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI 719
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 699 bits (1803), Expect = 0.0
Identities = 344/583 (59%), Positives = 441/583 (75%), Gaps = 6/583 (1%)
Query: 1 MEKILFYLFLIGIAVKA-QICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLA 59
ME +L L G+A CPK CVCQ LS +L TLC KGLLFVPP+IDRRTVELRL
Sbjct: 1 METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLG 60
Query: 60 DNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMF 119
NF+ +I R+DFANMT LVDLTLSRNTIS I P +F DL +LR+LHL+SNRL + D
Sbjct: 61 GNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120
Query: 120 SGLSNLHHLILNNNQLTLISSTAFDD-VFALEELDLSYNNLETIPWDAVEKMVSLHTLSL 178
GL NL HLI+NNNQL I+ AF+D + LE+LDLSYNNL +PWD+V +MV+LH LSL
Sbjct: 121 RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSL 180
Query: 179 DHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFG 238
DHN++D+I +GTF+ L K+ RLD+TSN+LQKLPPDP+F R+Q A + + SFG
Sbjct: 181 DHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG 240
Query: 239 GNPLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRV 298
GNPLHCNCELLWLRRL R+DDLETC SP L GRYFW + EEEF+CEPPLIT+HTH++ V
Sbjct: 241 GNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLV 300
Query: 299 LEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCI 358
LEGQ ATL+CKA GDP P IHW++P+ +L+ N++R+ VYDNGTLDI ITT +D+GAFTCI
Sbjct: 301 LEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCI 360
Query: 359 ASNPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNG---DTK 415
A+N AGEAT +V++ I++LPHL NST+ P SDI+ S+K+ S G
Sbjct: 361 AANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKS 420
Query: 416 LSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNN 475
+ ++V+E T+++AL+K++ ++ P ++M+Q+QYN + D+ L+YRMIP ++K F+VNN
Sbjct: 421 PPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNN 480
Query: 476 LAAGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGG 535
L +GT YDLCVLA++DD T+LTAT +VGC QF T+ DY +C M SQ LGGTMI++IGG
Sbjct: 481 LVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGG 540
Query: 536 IIVASVLVFIIILMIRYKVCNNNGQHKV-TKVSNVYSQTNGAQ 577
IIVA++LVFI+ILM+RYKVCN+ K+ VSNVYSQTNGAQ
Sbjct: 541 IIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQ 583
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 678 bits (1750), Expect = 0.0
Identities = 361/673 (53%), Positives = 465/673 (69%), Gaps = 36/673 (5%)
Query: 6 FYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTN 65
F L L A + Q CP RC+CQ ++P L LCAK GLLFVPP IDRR VELRL DNF+
Sbjct: 20 FLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAA 79
Query: 66 IKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNL 125
++R+DFANMTSLV LTLSRNTI + AFADLR LRALHL+SNRL ++ D GL NL
Sbjct: 80 VRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNL 139
Query: 126 HHLILNNNQLTLISSTAFDDVFA-LEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID 184
HLIL NNQ+ + S AFD + +E+LDLSYNNLE +PW+AV +MV+L+TL+LDHN+ID
Sbjct: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
Query: 185 NIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHC 244
+I +GTF LHK+ RLD+TSN+L KLPPD LF R+Q +G P+ +SFGGNPLHC
Sbjct: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQ---GTGPKPPTPLTVSFGGNPLHC 256
Query: 245 NCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTH-EMRVLEGQR 303
NCELLWLRRL+REDDLETCA+P LT RYFWSIPEEEFLCEPPLITR V+EGQ
Sbjct: 257 NCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQA 316
Query: 304 ATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPA 363
+LRC+A GDPEP +HW++P+G+L+ N++R+ V +GTLD+ ITT++D+G FTCIASN A
Sbjct: 317 VSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAA 376
Query: 364 GEATQIVDLHIIKLPHLLNSTNHIHEP--DPGSSDISTSTKSGSNTSSSNGDTKLSQDKI 421
GEAT V++ ++ LP L+ P +PGSSDI+T + G+N S++ + ++
Sbjct: 377 GEATAPVEVCVVPLP-LMAPPPAAPPPLTEPGSSDIATPGRPGANDSAA-------ERRL 428
Query: 422 VVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTM 481
V AE TS++ L+++ QR +PGIRM+Q+QYN + DD+LVYRMIP TS+TFLVN+LAAG
Sbjct: 429 VAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRA 488
Query: 482 YDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASV 541
YDLCVLA+YDDG T+L ATRVVGC+QFTT D C +++ FLGGTMII IGG+IVASV
Sbjct: 489 YDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASV 548
Query: 542 LVFIIILMIRYKVCNN------NGQHKVTKVSNVYSQTNGAQIQGCSV-TLPQSVSKQAV 594
LVFI++LMIRYKV + G + +VS+V SQTNGA LP +A+
Sbjct: 549 LVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEAL 608
Query: 595 GHEENAQCCKATSDNVIQSSETCSSQ----------DSSTTTSALPPSWTSS----TSVS 640
E+ + +ET S++ S+T+ LP TS +V
Sbjct: 609 REVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGEESRAAVG 668
Query: 641 QKQKRKTGTKPST 653
++ R +P T
Sbjct: 669 PRRSRSGALEPPT 681
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 592 bits (1525), Expect = e-169
Identities = 304/564 (53%), Positives = 398/564 (70%), Gaps = 9/564 (1%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP+RC CQ S L+ LC GLLFVPP++DRR ELRLADNF+ +++R+D ANMT L+
Sbjct: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L+LSRNTI + AFADLR LRALHL+ NRLT + GL NL HLIL+NNQL ++
Sbjct: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
Query: 140 STAFDDVF-ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMT 198
+ A DD LE+LDLSYNNLE +PW+A+ ++ +++TL LDHN++ ++P G FS LHK+
Sbjct: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
Query: 199 RLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSRED 258
RLD+TSN+L +PPDPLF R +LA S L+FGGNPLHCNCEL+WLRRL+RED
Sbjct: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARED 267
Query: 259 DLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAI 318
DLE CASPP L GRYFW++ EEEF+CEPP++T + + V G+ A LRC+A GDPEP +
Sbjct: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRV 327
Query: 319 HWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI--IK 376
W+SP+G+L+ N++R+ + NGTL++L+T D G FTCIA+N AGEAT V+L +
Sbjct: 328 RWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPP 387
Query: 377 LPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK-IVVAEATSSTALLKF 435
P L NST+ P G D T S ++ S+ DT D+ + V E ++ AL+++
Sbjct: 388 PPQLANSTS-CDPPRDGDPDALT-PPSAASASAKVADTGPPTDRGVQVTEHGATAALVQW 445
Query: 436 NFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGIT 495
QR IPGIRM+QIQYN + DD LVYRMIP S++FL+ +LA+G YDLCVLA+Y+D T
Sbjct: 446 PDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSAT 505
Query: 496 SLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVC 555
LTATR VGC +F+TE C + FLGGTMII +GG+IVASVLVFI +L++RYKV
Sbjct: 506 GLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVLLMRYKVH 565
Query: 556 NNN--GQHKV-TKVSNVYSQTNGA 576
G+ K+ VS+V SQTNGA
Sbjct: 566 GGQPPGKAKIPAPVSSVCSQTNGA 589
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 572 bits (1473), Expect = e-163
Identities = 294/570 (51%), Positives = 389/570 (68%), Gaps = 14/570 (2%)
Query: 8 LFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIK 67
L L+ +A A CP CVCQ LS +L+TLCA +GLLFVPPN+DRRTVELRLADNF+ +
Sbjct: 5 LLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALG 64
Query: 68 RKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHH 127
DF NMT LVDLTLSRN I+ I AF DL +LR+LHL+ NRL ++ G NL H
Sbjct: 65 PPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQH 124
Query: 128 LILNNNQLTLISSTAFDDVF-ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNI 186
LIL+ NQL I+ AFDD +LE+LDLSYNNL +PW + M +LHTL+LDHN+ID +
Sbjct: 125 LILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDAL 184
Query: 187 PKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNC 246
P G F+ L +++RLD+TSN+L L PDPLF R + SP+ LSF GNPLHCNC
Sbjct: 185 PPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGR----DAEASPAPLVLSFSGNPLHCNC 240
Query: 247 ELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATL 306
ELLWLRRL+R DDLETCASPP L GRYFW++PE EF CEPPLI RHT + VLEGQRATL
Sbjct: 241 ELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATL 300
Query: 307 RCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEA 366
RC+A GDP P +HW+ P+ +L+ N++R+ + NGTL+I +T D G +TCIA+NPAGEA
Sbjct: 301 RCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEA 360
Query: 367 TQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEA 426
T V+L ++ LPH NS+ PG SDI+ S + T++ T S+ + V E
Sbjct: 361 TARVELRVLALPHGGNSS--AEGGRPGPSDIAASAR----TAAEGEGTLESEPAVQVTEV 414
Query: 427 TSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCV 486
T+++ L+ + R + MFQIQYN + D+TL+YR++P +S FL+ +L G YDLC+
Sbjct: 415 TATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCL 474
Query: 487 LAIYD-DGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFI 545
LA+ G + LTATR++GC F+T CH +Q+ LGGT+ + +GG++VA++LVF
Sbjct: 475 LALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFT 534
Query: 546 IILMIRYKVCNNNGQHKVTKVSNVYSQTNG 575
+ L++R + N K+S+V SQTNG
Sbjct: 535 VALLVRGRGAGNG--RLPLKLSHVQSQTNG 562
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 164 bits (415), Expect = 3e-40
Identities = 141/501 (28%), Positives = 204/501 (40%), Gaps = 80/501 (15%)
Query: 8 LFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIK 67
L ++ V+AQ CP C C + +C +K L VP I T L L +N + IK
Sbjct: 35 LLVVAGLVRAQTCPSVCSCS--NQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92
Query: 68 RKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHH 127
F ++ L L LSRN I I AF L NL L L NRLT I N F LS L
Sbjct: 93 VNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKE 152
Query: 128 LILNNNQLTLISSTAFDDV----------------------------------------- 146
L L NN + I S AF+ +
Sbjct: 153 LWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI 212
Query: 147 ------FALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRL 200
L+ELDLS N+L I + + ++ L L + + I I + F +L + +
Sbjct: 213 PNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEI 272
Query: 201 DVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLR------RL 254
++ N L LP D LF L + NP +CNC++LWL
Sbjct: 273 NLAHNNLTLLPHD-LFTPLHHLER----------IHLHHNPWNCNCDILWLSWWIKDMAP 321
Query: 255 SREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDP 314
S C +PP L GRY + + F C P+I ++ V EG A L+C+A
Sbjct: 322 SNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STS 380
Query: 315 EPAIHWISPEGKLISNA---TRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVD 371
++ WI+P G ++++ R V +GTL+ TV+DTG +TC+ SN G T
Sbjct: 381 LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASAT 440
Query: 372 LHI---IKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNT-----SSSNGDTKLSQDKIVV 423
L++ P ST + +P + T+ + T ++N T L+
Sbjct: 441 LNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRS 500
Query: 424 AEATSSTALLKFNFQRNIPGI 444
E T + + N IPGI
Sbjct: 501 TEKTFTIPVTDIN--SGIPGI 519
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 155 bits (393), Expect = 9e-38
Identities = 119/417 (28%), Positives = 177/417 (42%), Gaps = 76/417 (18%)
Query: 17 AQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTS 76
A CP C C + + +C ++ L VP +I T L L +N + I+ F ++
Sbjct: 54 ATSCPVACSCSNQASRV--ICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
Query: 77 LVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLT 136
L L LS+N + I AF L +L L L NRLT + F LS L L L NN +
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171
Query: 137 LISSTAFDDV-----------------------------------------------FAL 149
I S AF+ V L
Sbjct: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRL 231
Query: 150 EELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQK 209
EEL+LS N L+ I + + + SL L L H + I + F L + L+++ N L
Sbjct: 232 EELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMS 291
Query: 210 LPPD---PLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET---- 262
LP D PL + +V NP HCNC++LWL +E
Sbjct: 292 LPHDLFTPLHRLERV--------------HLNHNPWHCNCDVLWLSWWLKETVPSNTTCC 337
Query: 263 --CASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHW 320
C +P L GRY + + F C P+I ++ V EG A L+C+ G +++W
Sbjct: 338 ARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNW 396
Query: 321 ISPEGKLISNAT---RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI 374
++P G L+++ + R V +GTL+ TV+DTG +TC+ +N AG T L++
Sbjct: 397 LTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 147 bits (372), Expect = 3e-35
Identities = 104/316 (32%), Positives = 145/316 (45%), Gaps = 46/316 (14%)
Query: 72 ANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILN 131
A TS++DL +R I I P AF LRNL L LN+N++ +I + F L NL +L L
Sbjct: 61 APQTSILDLRFNR--IREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLY 118
Query: 132 NNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTF 191
N++ I AF + +LE+L L +N +ET+ D+ + + L L L +N I ++ GTF
Sbjct: 119 KNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTF 178
Query: 192 SHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWL 251
+HL M RL + S N LHC+CE+LWL
Sbjct: 179 NHLESMKRLRLDS-----------------------------------NTLHCDCEILWL 203
Query: 252 RRL-------SREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRA 304
L C P + GR +I EE CE P IT + V G
Sbjct: 204 ADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTV 263
Query: 305 TLRCKARGDPEPAIHWISPEGKL-ISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPA 363
C+A G+P+P I W+ +L + +R + D+GTL I T D G + C+A N A
Sbjct: 264 YFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVA 323
Query: 364 GEA-TQIVDLHIIKLP 378
GE TQ V L P
Sbjct: 324 GEVKTQEVTLRYFGSP 339
Score = 83.2 bits (204), Expect = 8e-16
Identities = 96/393 (24%), Positives = 145/393 (36%), Gaps = 63/393 (16%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP RC+C + L LL P + +T L L N + I+ F + +L
Sbjct: 36 CPSRCLCFRTTVRCMHL-----LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNT 90
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L L+ N I I AF DL NL+ L+L N + I F GL++L L L+ NQ+ +
Sbjct: 91 LLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLD 150
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI----------DNIPKG 189
+F + LE L L N + + + S+ L LD N + D +
Sbjct: 151 PDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTY 210
Query: 190 TFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNC--- 246
S + + ++Q + I S A GN ++ C
Sbjct: 211 AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAE 270
Query: 247 -----ELLWLR-----------RLSREDD--------------LETCASPPL-------- 268
E++WLR RL+ DD + C + +
Sbjct: 271 GNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQE 330
Query: 269 LTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLI 328
+T RYF S F+ +P VL G+ TL C A G P P I W + +
Sbjct: 331 VTLRYFGSPARPTFVIQP-------QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383
Query: 329 SNATRSLVYDNGTLDILITTVKDTGAFTCIASN 361
R + +G L I D+G + C A+N
Sbjct: 384 PVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Score = 49.3 bits (116), Expect = 1e-05
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 287 PLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILI 346
P T + V+EGQ +C+A+G+P P I W + G +S R LV +GTL I
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW-TKGGSQLSVDRRHLVLSSGTLRISG 491
Query: 347 TTVKDTGAFTCIASNPAGEATQIVDLHI 374
+ D G + C A N G + L +
Sbjct: 492 VALHDQGQYECQAVNIIGSQKVVAHLTV 519
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 287 PLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILI 346
P+ + V G L C ++G+PEPAI W + +G ++ + + + G L I
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITW-NKDGVQVTESGKFHISPEGFLTIND 583
Query: 347 TTVKDTGAFTCIASNPAGEAT 367
D G + C+A N G A+
Sbjct: 584 VGPADAGRYECVARNTIGSAS 604
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 145 bits (365), Expect = 2e-34
Identities = 106/336 (31%), Positives = 152/336 (45%), Gaps = 49/336 (14%)
Query: 75 TSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQ 134
T+++DL +R I I AF L+NL L LN+N + KI+ + F GL NL +L L N+
Sbjct: 52 TTVLDLRFNR--IREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
Query: 135 LTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHL 194
+ + F + +LE L + +N LE + + ++ L L L +N + IP G+FS+L
Sbjct: 110 IHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL 169
Query: 195 HKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRL 254
+ RL + SN L C+C+L+WL L
Sbjct: 170 DSLKRLRLDSNALV-----------------------------------CDCDLMWLGEL 194
Query: 255 -------SREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLR 307
TC P L GR S+ EEF C+ P IT ++ V G
Sbjct: 195 LQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFT 254
Query: 308 CKARGDPEPAIHWISPEGKL-ISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEA 366
C+A G+P+P I WI L + + TR V+D+GTL I T D G + C+A N AGEA
Sbjct: 255 CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
Query: 367 -TQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTST 401
TQ L LP + + +P I TST
Sbjct: 315 KTQSAMLRYSSLP---AKPSFVIQPQDTEVLIGTST 347
Score = 96.7 bits (239), Expect = 7e-20
Identities = 110/421 (26%), Positives = 159/421 (37%), Gaps = 63/421 (14%)
Query: 8 LFLI-GIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNI 66
LFL+ G + CP RC+C +T+ +L P + ++T L L N + I
Sbjct: 11 LFLLAGWCLPGLPCPSRCLCF-----KSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREI 65
Query: 67 KRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLH 126
F + +L L L+ N I I+ +AF L NL L+L N + + F GL +L
Sbjct: 66 PGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLE 125
Query: 127 HLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI--- 183
HL ++ NQL ++ F D+ LE L L N L IP + + SL L LD N +
Sbjct: 126 HLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCD 185
Query: 184 ------DNIPKGTFSH--------------LHKMTRLDVTSNKLQKLPPDPLFQRAQVLA 223
+ +G H LH VT + P F+ V
Sbjct: 186 CDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEV 245
Query: 224 TSGIISPSTFALSFGGNPLHCNCELLWLRR---LSREDDLE-TCASPPLLTGRYFWSIPE 279
SG + F GNP E++W+ L EDD L R +
Sbjct: 246 PSG--NTVYFTCRAEGNP---KPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
Query: 280 EEFLC----------------------EPPLITRHTHEMRVLEGQRATLRCKARGDPEPA 317
+ C P + VL G TL C A G P P
Sbjct: 301 GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL 360
Query: 318 IHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL 377
I W G L + +R + +G L + T +D G FTC A+N G ++ I++
Sbjct: 361 ITWTRDNG-LELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQAAANI-IVQA 417
Query: 378 P 378
P
Sbjct: 418 P 418
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 288 LITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILIT 347
+ T+ + V G+ + C A+G+P+P I W + EG I+ + + V D GTL I
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIITW-NKEGVQITESGKFHVDDEGTLTIYDA 570
Query: 348 TVKDTGAFTCIASNPAGEA 366
D G + C+A N G A
Sbjct: 571 GFPDQGRYECVARNSFGLA 589
Score = 37.4 bits (85), Expect = 0.049
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 1/89 (1%)
Query: 286 PPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDIL 345
PP T + VLE C+A G+P P I W G+L + V +GTL I
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT-VLSSGTLRID 476
Query: 346 ITTVKDTGAFTCIASNPAGEATQIVDLHI 374
D G + C A + G V L +
Sbjct: 477 RAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 142 bits (358), Expect = 1e-33
Identities = 96/357 (26%), Positives = 163/357 (45%), Gaps = 24/357 (6%)
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
L + DN + + R+ FA + +L +LTL R ++ ++ + LR+L AL L + +
Sbjct: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
Query: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHT 175
+ F L L HL ++N L + L L +++ N+ +P A+ L
Sbjct: 215 DQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTC 274
Query: 176 LSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATS------GIIS 229
L+L HN I +P+G+F L ++ L + L + P Q+ + +
Sbjct: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
Query: 230 PSTF-------ALSFGGNPLHCNCELLWL----RRLSREDDLETCASPPLLTGRYFWSIP 278
STF L GNPL C+C LLW+ + L+ + L CA+P + G ++P
Sbjct: 335 ESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLP 394
Query: 279 E----EEFLCEPPLI-TRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLI--SNA 331
+ E F+C P I R + G+ C+A G+P P + W++P+ + + ++A
Sbjct: 395 DSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSA 454
Query: 332 TRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIH 388
R+ V GTL+I +D+G +TC+ASN G T L + P + H
Sbjct: 455 GRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAH 511
Score = 89.7 bits (221), Expect = 8e-18
Identities = 56/181 (30%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP RC C + + +A C ++ L VP I T L L+ N + + D A + +L +
Sbjct: 25 CPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEE 82
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L LS N I+ + P AFA+L LR L L N+L I +F+ L NL L L+ N+L ++
Sbjct: 83 LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILL 142
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
F D+ +L L++ N+L + A +++L L+L+ + + + HL +
Sbjct: 143 DYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGA 202
Query: 200 L 200
L
Sbjct: 203 L 203
Score = 33.9 bits (76), Expect = 0.54
Identities = 17/61 (27%), Positives = 33/61 (54%)
Query: 152 LDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLP 211
L+LS N + + + + +L L L N I ++ G F++L ++ L + N+L+ +P
Sbjct: 59 LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118
Query: 212 P 212
P
Sbjct: 119 P 119
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 141 bits (356), Expect = 2e-33
Identities = 120/438 (27%), Positives = 185/438 (42%), Gaps = 73/438 (16%)
Query: 7 YLFLIGIAVKAQICPKRC--VCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVT 64
++ IA A P+ C VC + +C ++GL VP I T L L +N +
Sbjct: 29 WILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQ 88
Query: 65 NIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSN 124
I+ F ++ L L L RN+I I AF L +L L L N LT I + F LS
Sbjct: 89 MIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSK 148
Query: 125 LHHLILNNN-------------------------QLTLISSTAFDDVF------------ 147
L L L NN +L IS AF+ +F
Sbjct: 149 LRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNI 208
Query: 148 ----------ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKM 197
LEEL++S N+ I + + SL L + ++ + I + F L +
Sbjct: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASL 268
Query: 198 TRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSRE 257
L++ N L LP D LF + L L NP +C+C++LWL RE
Sbjct: 269 VELNLAHNNLSSLPHD-LFTPLRYLVE----------LHLHHNPWNCDCDILWLAWWLRE 317
Query: 258 ------DDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKAR 311
C +P + GRY + + F C P I ++ + EG+ A L+C R
Sbjct: 318 YIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKC--R 375
Query: 312 GDPEPAIHWISPEGKLISNATRS---LVYDNGTLDILITTVKDTGAFTCIASNPAGEATQ 368
P ++ W+ P G ++S+A+R V ++GTL+ + DTG +TC+ +N AG +
Sbjct: 376 TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNA 435
Query: 369 IVDLHIIKLPHLLNSTNH 386
L++ LN++N+
Sbjct: 436 SAYLNVSTAE--LNTSNY 451
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 141 bits (355), Expect = 2e-33
Identities = 125/477 (26%), Positives = 189/477 (39%), Gaps = 126/477 (26%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTV------------------------E 55
CP RC C + N + C ++ L+ +P I T E
Sbjct: 28 CPARCECS--AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
Query: 56 LRLADNFVTNIKRKDFANM------------------------TSLVDLTLSRNTISFIT 91
+ L+DN + N++ F N+ ++L L +S N I +
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
Query: 92 PHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTA--------- 142
+ F DL NL++L + N L I++ FSGL +L L L LT + + A
Sbjct: 146 DYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIS 205
Query: 143 ---------------FDDVFALEELDLSY------------------------NNLETIP 163
F +F L+ L++ Y NL T+P
Sbjct: 206 LHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVP 265
Query: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL----FQRA 219
+ A + +V L L+L +N I I G FS L ++ L + +L+ + P F R
Sbjct: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
Query: 220 --------QVLATSGIISPSTF-ALSFGGNPLHCNCELLWLRRLSREDDLE------TCA 264
+ L + SP LS NPL C+C LLW+ L R+ L+ CA
Sbjct: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCA 383
Query: 265 SPPLLTGRYFWSIPEEE----FLCEPPLI-TRHTHEMRVLEGQRATLRCKARGDPEPAIH 319
P + R F F C+ P I + + V EGQ L C A GDP+P I
Sbjct: 384 GPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVIS 443
Query: 320 WISPEGKLISNAT--RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI 374
W++P + I+ + R+ V +GTL+I +D+G + CIASN AG T L +
Sbjct: 444 WVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 138 bits (348), Expect = 2e-32
Identities = 129/505 (25%), Positives = 195/505 (38%), Gaps = 126/505 (24%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP RC C + + A LC +K + VP I T L L N + + + +FA+ L +
Sbjct: 42 CPPRCECS--AQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEE 99
Query: 80 LTLSRNTISFITPHAF-------------------------------------------- 95
L L+ N +S + P AF
Sbjct: 100 LELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILL 159
Query: 96 ----ADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTA--------- 142
DL NL++L + N L I++ FSGL++L L L LT I + A
Sbjct: 160 DYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 219
Query: 143 ---------------FDDVFALEELDLSY------------------------NNLETIP 163
F ++ L+ L++S+ NL +P
Sbjct: 220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP 279
Query: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL--FQRAQV 221
+ AV +V L L+L +N I I L ++ + + +L + P +V
Sbjct: 280 YLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRV 339
Query: 222 LATSG----IISPSTF-------ALSFGGNPLHCNCELLWLRR----LSREDDLETCASP 266
L SG + S F L NPL C+C LLW+ R L+ TCA+P
Sbjct: 340 LNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATP 399
Query: 267 PLLTGRYFWSIPE----EEFLCEPPLIT-RHTHEMRVLEGQRATLRCKARGDPEPAIHWI 321
+ G+ F P+ F C I R ++ V EG C+A GDP PAI W+
Sbjct: 400 EFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL 459
Query: 322 SPEGKLISNAT--RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL-- 377
SP L+S + R V+ +GTL++ V+D G + CIA+N G + LH+
Sbjct: 460 SPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSP 519
Query: 378 --PHLLNSTNHIHEPDPGSSDISTS 400
PH N T PG + +++
Sbjct: 520 DWPHQPNKTFAFISNQPGEGEANST 544
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 132 bits (332), Expect = 1e-30
Identities = 109/393 (27%), Positives = 170/393 (43%), Gaps = 74/393 (18%)
Query: 54 VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTK 113
+ L L +N +T ++ FA + SL +L L+ N + I P AF+ L NL LHLNSN L
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
Query: 114 ITN-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFAL 149
I + DM F L+NL L+L L IS A + + +L
Sbjct: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
Query: 150 EELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS----------------- 192
E L N L +P A+E++ L L L+ N + + G F+
Sbjct: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
Query: 193 --------HLHKMTRLDVTSN-KLQKLPP---DPLFQRAQVLATSGIIS----------P 230
+L ++T+LD+T+N +L + P L Q ++ + +S P
Sbjct: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
Query: 231 STFALSFGGNPLHCNCELLWLRRLSR-----EDDLETCASPPLLTGRYFWSIPEEEFL-- 283
+ + GNP+ C+C + W E CA PP L +P E
Sbjct: 360 NLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDH 419
Query: 284 CEPPLITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNA---TRSLVYDN 339
C P + R ++V G+ L C+A +PEP I+W++P G ++ A R VY
Sbjct: 420 CLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPE 479
Query: 340 GTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372
GTL++ T ++ G +TC+A N G T+ V +
Sbjct: 480 GTLELRRVTAEEAGLYTCVAQNLVGADTKTVSV 512
Score = 84.7 bits (208), Expect = 3e-16
Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 9/200 (4%)
Query: 20 CPKRCVCQIL-------SPNLATL--CAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKD 70
CP +C CQI S AT C L VPP + T L L N + + + +
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 71 FANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLIL 130
+ +L +L LS+N+ S F L L +LHL N+LT++ + F+GL++L L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 131 NNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGT 190
N+NQL I+ AF + L L L+ N L I E + +L L + N +D I
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 191 FSHLHKMTRLDVTSNKLQKL 210
F L + L + L+++
Sbjct: 209 FRPLANLRSLVLAGMNLREI 228
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 132 bits (332), Expect = 1e-30
Identities = 109/393 (27%), Positives = 170/393 (43%), Gaps = 74/393 (18%)
Query: 54 VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTK 113
+ L L +N +T ++ FA + SL +L L+ N + I P AF+ L NL LHLNSN L
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
Query: 114 ITN-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFAL 149
I + DM F L+NL L+L L IS A + + +L
Sbjct: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
Query: 150 EELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS----------------- 192
E L N L +P A+E++ L L L+ N + + G F+
Sbjct: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
Query: 193 --------HLHKMTRLDVTSN-KLQKLPP---DPLFQRAQVLATSGIIS----------P 230
+L ++T+LD+T+N +L + P L Q ++ + +S P
Sbjct: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
Query: 231 STFALSFGGNPLHCNCELLWLRRLSR-----EDDLETCASPPLLTGRYFWSIPEEEFL-- 283
+ + GNP+ C+C + W E CA PP L +P E
Sbjct: 360 NLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDH 419
Query: 284 CEPPLITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNA---TRSLVYDN 339
C P + R ++V G+ L C+A +PEP I+W++P G ++ A R VY
Sbjct: 420 CLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPE 479
Query: 340 GTLDILITTVKDTGAFTCIASNPAGEATQIVDL 372
GTL++ T ++ G +TC+A N G T+ V +
Sbjct: 480 GTLELRRVTAEEAGLYTCVAQNLVGADTKTVSV 512
Score = 84.7 bits (208), Expect = 3e-16
Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 9/200 (4%)
Query: 20 CPKRCVCQIL-------SPNLATL--CAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKD 70
CP +C CQI S AT C L VPP + T L L N + + + +
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 71 FANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLIL 130
+ +L +L LS+N+ S F L L +LHL N+LT++ + F+GL++L L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 131 NNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGT 190
N+NQL I+ AF + L L L+ N L I E + +L L + N +D I
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 191 FSHLHKMTRLDVTSNKLQKL 210
F L + L + L+++
Sbjct: 209 FRPLANLRSLVLAGMNLREI 228
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 129 bits (325), Expect = 7e-30
Identities = 112/429 (26%), Positives = 185/429 (43%), Gaps = 75/429 (17%)
Query: 58 LADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITND 117
L +N +T + K + +++L +L ++ N +S I+P AF L NL LHLNSNRL I +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 118 MFSGLSNLHHLILNNN------------------------QLTLISSTAFDDVFALEELD 153
F L NL L++ N LT I A + LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 154 LSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS--------------------- 192
N L +P A++K+V+L L L+ N I+ I +G FS
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302
Query: 193 ----HLHKMTRLDVTSN-KLQKLPPDPLFQRAQ---VLATSGIIS----------PSTFA 234
+L + +++ T+N +L + P+ F+ + ++ S +S P+
Sbjct: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362
Query: 235 LSFGGNPLHCNCELLWLRRLS-----REDDLETCASPPLLTGRYFWSIPEEEF--LCEPP 287
+S NP+ C+C + W+ E D C PP G+ + + +C P
Sbjct: 363 ISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPL 422
Query: 288 LITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG-KLISN--ATRSLVYDNGTLD 343
+ + V G + C+A +P+P I+WI+P G KL+ N + V+ GTLD
Sbjct: 423 IAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLD 482
Query: 344 ILITTVKDTGAFTCIASNPAGEATQIVDLHII-KLPHLLNSTNHIHEPDPGSSDISTSTK 402
I T K+ G +TCIA+N G + V + + P N + +I D ++ + S K
Sbjct: 483 INGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWK 542
Query: 403 SGSNTSSSN 411
+ S S+
Sbjct: 543 ASSKILKSS 551
Score = 75.1 bits (183), Expect = 2e-13
Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 10 LIGIAVKAQI--------CPKRCVCQI---LSPNLATL------CAKKGLLFVPPNIDRR 52
L+G+A+ + CP+ C C+I +P + C GLL P +
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 53 TVELRLADNFVTNIKRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111
T L L N + I+ DF +L L LS+N +S +T + L +++L N+L
Sbjct: 71 TQILLLQTNNIAKIEYSTDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKL 128
Query: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171
T++ S LSNL L +N+N L+ IS AF + L L L+ N L+ I + +
Sbjct: 129 TELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALP 188
Query: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
+L L + N I I F L + L + L ++P + L
Sbjct: 189 NLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 129 bits (325), Expect = 7e-30
Identities = 112/429 (26%), Positives = 185/429 (43%), Gaps = 75/429 (17%)
Query: 58 LADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITND 117
L +N +T + K + +++L +L ++ N +S I+P AF L NL LHLNSNRL I +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 118 MFSGLSNLHHLILNNN------------------------QLTLISSTAFDDVFALEELD 153
F L NL L++ N LT I A + LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 154 LSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS--------------------- 192
N L +P A++K+V+L L L+ N I+ I +G FS
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302
Query: 193 ----HLHKMTRLDVTSN-KLQKLPPDPLFQRAQ---VLATSGIIS----------PSTFA 234
+L + +++ T+N +L + P+ F+ + ++ S +S P+
Sbjct: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362
Query: 235 LSFGGNPLHCNCELLWLRRLS-----REDDLETCASPPLLTGRYFWSIPEEEF--LCEPP 287
+S NP+ C+C + W+ E D C PP G+ + + +C P
Sbjct: 363 ISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPL 422
Query: 288 LITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG-KLISN--ATRSLVYDNGTLD 343
+ + V G + C+A +P+P I+WI+P G KL+ N + V+ GTLD
Sbjct: 423 IAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLD 482
Query: 344 ILITTVKDTGAFTCIASNPAGEATQIVDLHII-KLPHLLNSTNHIHEPDPGSSDISTSTK 402
I T K+ G +TCIA+N G + V + + P N + +I D ++ + S K
Sbjct: 483 INGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWK 542
Query: 403 SGSNTSSSN 411
+ S S+
Sbjct: 543 ASSKILKSS 551
Score = 75.1 bits (183), Expect = 2e-13
Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 10 LIGIAVKAQI--------CPKRCVCQI---LSPNLATL------CAKKGLLFVPPNIDRR 52
L+G+A+ + CP+ C C+I +P + C GLL P +
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 53 TVELRLADNFVTNIKRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111
T L L N + I+ DF +L L LS+N +S +T + L +++L N+L
Sbjct: 71 TQILLLQTNNIAKIEYSTDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKL 128
Query: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171
T++ S LSNL L +N+N L+ IS AF + L L L+ N L+ I + +
Sbjct: 129 TELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALP 188
Query: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
+L L + N I I F L + L + L ++P + L
Sbjct: 189 NLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 129 bits (325), Expect = 7e-30
Identities = 112/429 (26%), Positives = 185/429 (43%), Gaps = 75/429 (17%)
Query: 58 LADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITND 117
L +N +T + K + +++L +L ++ N +S I+P AF L NL LHLNSNRL I +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 118 MFSGLSNLHHLILNNN------------------------QLTLISSTAFDDVFALEELD 153
F L NL L++ N LT I A + LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 154 LSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS--------------------- 192
N L +P A++K+V+L L L+ N I+ I +G FS
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302
Query: 193 ----HLHKMTRLDVTSN-KLQKLPPDPLFQRAQ---VLATSGIIS----------PSTFA 234
+L + +++ T+N +L + P+ F+ + ++ S +S P+
Sbjct: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362
Query: 235 LSFGGNPLHCNCELLWLRRLS-----REDDLETCASPPLLTGRYFWSIPEEEF--LCEPP 287
+S NP+ C+C + W+ E D C PP G+ + + +C P
Sbjct: 363 ISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPL 422
Query: 288 LITR-HTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG-KLISN--ATRSLVYDNGTLD 343
+ + V G + C+A +P+P I+WI+P G KL+ N + V+ GTLD
Sbjct: 423 IAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLD 482
Query: 344 ILITTVKDTGAFTCIASNPAGEATQIVDLHII-KLPHLLNSTNHIHEPDPGSSDISTSTK 402
I T K+ G +TCIA+N G + V + + P N + +I D ++ + S K
Sbjct: 483 INGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWK 542
Query: 403 SGSNTSSSN 411
+ S S+
Sbjct: 543 ASSKILKSS 551
Score = 75.1 bits (183), Expect = 2e-13
Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 10 LIGIAVKAQI--------CPKRCVCQI---LSPNLATL------CAKKGLLFVPPNIDRR 52
L+G+A+ + CP+ C C+I +P + C GLL P +
Sbjct: 11 LLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPAN 70
Query: 53 TVELRLADNFVTNIKRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111
T L L N + I+ DF +L L LS+N +S +T + L +++L N+L
Sbjct: 71 TQILLLQTNNIAKIEYSTDFP--VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKL 128
Query: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171
T++ S LSNL L +N+N L+ IS AF + L L L+ N L+ I + +
Sbjct: 129 TELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALP 188
Query: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
+L L + N I I F L + L + L ++P + L
Sbjct: 189 NLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 127 bits (318), Expect = 5e-29
Identities = 106/356 (29%), Positives = 148/356 (41%), Gaps = 44/356 (12%)
Query: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
+L + DN + + FA + L LTL R +S + A A L L AL L + ++
Sbjct: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
Query: 115 TNDMFSGLSNLHHLI-----------------LNNNQLTL----ISSTAFDDVFALE--- 150
GL L L LN + L + +SS F ++ L
Sbjct: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLR 279
Query: 151 ELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKL 210
LDLS N + IP + +V L L L + +I F L LDV N LQ L
Sbjct: 280 VLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTL 339
Query: 211 PPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDL----ETCASP 266
+ F L T L GNPL C+C LLWL RL R D CA P
Sbjct: 340 E-ETAFPSPDKLVT----------LRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGP 388
Query: 267 PLLTGRYFWS----IPEEEFLCEPPLITRHTHEMRVLE-GQRATLRCKARGDPEPAIHWI 321
+ G+ +P F C+P LI + + E G A C GDP P + W+
Sbjct: 389 HHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWM 448
Query: 322 SPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL 377
P G + A R V ++GTL+I ++D GA+ C+ SN AG + L +I++
Sbjct: 449 RPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQV 504
Score = 84.0 bits (206), Expect = 5e-16
Identities = 70/235 (29%), Positives = 112/235 (47%), Gaps = 4/235 (1%)
Query: 4 ILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFV 63
+LF L L G + + CP VC S A LC + L VP + T L L+ N +
Sbjct: 17 LLFLLLLPGGSGGS--CP--AVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRL 72
Query: 64 TNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS 123
+++ + ++ L +L LS N +S + P AF L++L L L NRL + +FSGLS
Sbjct: 73 WGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLS 132
Query: 124 NLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183
L L L NQ+ L AF ++ +L++L++ N+L + A + L TL+L+ +
Sbjct: 133 ALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNL 192
Query: 184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFG 238
+P + L + L + + +LP L Q+ + PS AL G
Sbjct: 193 STVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPG 247
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 122 bits (307), Expect = 9e-28
Identities = 120/437 (27%), Positives = 187/437 (42%), Gaps = 88/437 (20%)
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
L L +N +T + ++++L +L ++ N IS I+ HAFA L+NL LHLNSN+L I
Sbjct: 124 LHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVID 183
Query: 116 N-----------------------DM-FSGLSNLHHLILNNNQLTLISSTAFDDVFALEE 151
+ DM F L+NL L+L LT I A + +LE
Sbjct: 184 SRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLES 243
Query: 152 LDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTF-------------------- 191
L N L +P A++K+ +L L L+ N I I +G F
Sbjct: 244 LSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSV 303
Query: 192 -----SHLHKMTRLDVTSNKLQKLPPDPLFQRAQVL--------ATSGIIS------PST 232
+L ++T+L+ T+N F+ L A + I P+
Sbjct: 304 DRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNL 363
Query: 233 FALSFGGNPLHCNCELLWLRRLSREDDLE-------TCASPPLLTGRYFWSI----PEEE 281
+S NPL C+C + W+ S + ++ CA PP G + E+
Sbjct: 364 REISIHSNPLRCDCVIHWIN--SNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQ 421
Query: 282 FLCEPPLITRHT--HEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVY-- 337
L P+I+ + + + V G L C+A +PEP I+W++P G I+ T S Y
Sbjct: 422 CL---PMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKL 478
Query: 338 -DNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTN--HIHEPDPGS 394
GTL+I ++D+G +TC+A N G T++ + + LL+ T I+ S
Sbjct: 479 SSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGT--LLDGTQVLKIYVKQTES 536
Query: 395 SDISTSTKSGSNTSSSN 411
I S K SN +SN
Sbjct: 537 HSILVSWKVNSNVMTSN 553
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/256 (29%), Positives = 110/256 (42%), Gaps = 43/256 (16%)
Query: 20 CPKRCVCQI---LSPNL----ATL--CAKKGLLFVPPNIDRRT----------------- 53
CP+ CVC+I +P AT C L +P N+ T
Sbjct: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDEL 91
Query: 54 ------VELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLN 107
EL + N TNIK AN+T L L L N I+ +T + DL NL+ L++N
Sbjct: 92 QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYIN 151
Query: 108 SNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAV 167
N+++ I+ F+GL NL L LN+N+L +I S FD LE L + N + I
Sbjct: 152 HNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNF 211
Query: 168 EKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGI 227
+ + +L +L L + +IP L + L NKL K+P LA +
Sbjct: 212 KPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQ---------LALQKV 262
Query: 228 ISPSTFALSFGGNPLH 243
P+ L NP+H
Sbjct: 263 --PNLKFLDLNKNPIH 276
>gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
Length = 634
Score = 120 bits (300), Expect = 6e-27
Identities = 105/358 (29%), Positives = 161/358 (44%), Gaps = 28/358 (7%)
Query: 104 LHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIP 163
L + + +I+ + F L L +L + N + I ++F ++ L EL L N+L P
Sbjct: 17 LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFP 76
Query: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLA 223
W ++ M L TL L +N I ++P +L + LD++SN+L LPPD L +++
Sbjct: 77 WASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVS 136
Query: 224 T-SGI--ISPSTFALSFGGNPLHCNCELLWLRRLSRE--------DDLETCASPPLLTGR 272
T SG+ +SPS L NP C+C + + LS+ D L TC+ P LTG
Sbjct: 137 TPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGI 196
Query: 273 YFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332
F E E +P ++T T M L G LRC A G P P I W + ++
Sbjct: 197 LF-QRAELEHCLKPSVMTSATKIMSAL-GSNVLLRCDATGFPTPQITWTRSDSSPVNYTV 254
Query: 333 RSLVYDNGT----LDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL------PHLLN 382
+ G + + + KD G + C A N AG + +V + ++ + P
Sbjct: 255 IQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSE 314
Query: 383 STNHIHEPD--PGSSDISTSTKSGSN--TSSSNGDTKLSQDKIVVAEATSSTALLKFN 436
T E D PGS STS S S+ SSS T + +T+S +L F+
Sbjct: 315 RTGDHPEWDVQPGSGR-STSVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFS 371
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 106 bits (265), Expect = 7e-23
Identities = 82/275 (29%), Positives = 114/275 (41%), Gaps = 43/275 (15%)
Query: 17 AQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTS 76
A CP +C C S + C GL VP I R N +R D
Sbjct: 31 AVACPTKCTCSAASVD----CHGLGLRAVPRGIPR-------------NAERLD------ 67
Query: 77 LVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLT 136
L RN I+ IT FA L+NLR LHL N+++ I F L L L LN N+L
Sbjct: 68 -----LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ 122
Query: 137 LISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHK 196
++ F L LDLS N ++ IP A + + L LD+N I I G F L
Sbjct: 123 VLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRD 182
Query: 197 MTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL----WLR 252
+ L + +N + +++L TS P L N L+C+C L WLR
Sbjct: 183 LEILTLNNNNI-----------SRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLR 231
Query: 253 RLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPP 287
+ C +P L G + ++E++C P
Sbjct: 232 QRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP 266
Score = 94.7 bits (234), Expect = 3e-19
Identities = 71/269 (26%), Positives = 107/269 (39%), Gaps = 67/269 (24%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP C C N C KGL+ +P N+ VE+RL N + I F L
Sbjct: 280 CPSPCTCS----NNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKR 335
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
+ +S+N IS I P AF L++L +L L N++T+I +F GL +L L+LN N++ +
Sbjct: 336 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLR 395
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
F D + +L+ LSL N + I KG F+ L +
Sbjct: 396 VNTFQD------------------------LQNLNLLSLYDNKLQTISKGLFAPLQSIQT 431
Query: 200 LDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDD 259
L + N P C+C L WL +++
Sbjct: 432 LHLAQN-----------------------------------PFVCDCHLKWLADYLQDNP 456
Query: 260 LET----CASPPLLTGRYFWSIPEEEFLC 284
+ET C+SP L + I ++F C
Sbjct: 457 IETSGARCSSPRRLANKRISQIKSKKFRC 485
Score = 80.9 bits (198), Expect = 4e-15
Identities = 66/273 (24%), Positives = 103/273 (37%), Gaps = 92/273 (33%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP++C C C+ KGL +P + + EL L N +T +
Sbjct: 725 CPEQCTCM----ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV------------- 767
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
P + LR+L + L++N ++ +TN FS +S+L LI
Sbjct: 768 ------------PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLI---------- 805
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
LSYN L IP A + SL L+L N I ++P+G+F+ L ++
Sbjct: 806 --------------LSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851
Query: 200 LDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWL----RRLS 255
L+ G NPLHC+C L WL +
Sbjct: 852 -----------------------------------LALGTNPLHCDCSLRWLSEWVKAGY 876
Query: 256 REDDLETCASPPLLTGRYFWSIPEEEFLCEPPL 288
+E + C+SP + R + P F C+ P+
Sbjct: 877 KEPGIARCSSPEPMADRLLLTTPTHRFQCKGPV 909
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 16/187 (8%)
Query: 104 LHLNSNRLTKI-TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETI 162
L LN N ++ + +F L NL + L+NN++ + AFD +++EL L+ N LET+
Sbjct: 537 LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETV 596
Query: 163 PWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVL 222
+ L TL L N+I + TF+ L + L + N++ + P
Sbjct: 597 HGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPG--------- 647
Query: 223 ATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET----CASPPLLTGRYFWSIP 278
A + ++S ST L NP +CNC L WL + R+ + + C P L +
Sbjct: 648 AFTTLVSLSTINLL--SNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVA 705
Query: 279 EEEFLCE 285
++F C+
Sbjct: 706 IQDFTCD 712
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 106 bits (265), Expect = 7e-23
Identities = 69/220 (31%), Positives = 108/220 (49%), Gaps = 9/220 (4%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP C C S C ++ VP + + L++ + +T + F N+++L+
Sbjct: 31 CPSECTCSRASQ---VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIA 87
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L + +N +S ITP AF +L +LR L L +N+L + +F GL +L L+L++NQL I
Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
F L+EL L N+LE IP A + +V L L+L N + +I F HL +
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207
Query: 200 LDVTSNKLQKLPPDPL--FQRAQVLATS----GIISPSTF 233
L + N+L +P Q LA G++SP F
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLF 247
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/185 (31%), Positives = 89/185 (48%), Gaps = 6/185 (3%)
Query: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
EL+L N + I F ++ L L L +N+++ I+P F L NL+ L L NRLT I
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
Query: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLH 174
F GL NL L L NQ+ L+S F + L+ L LS N++ +P ++ L+
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278
Query: 175 TLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL--FQRAQVLATS----GII 228
L+L N + + G F + + L + N + LP + ++ QVL S I
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 338
Query: 229 SPSTF 233
SP F
Sbjct: 339 SPGAF 343
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/225 (27%), Positives = 109/225 (48%), Gaps = 20/225 (8%)
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
L L++N ++ + F + L LTL N++ ++ F + NLR L L N ++ +
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHT 175
+++FS L L LIL+ NQ++ IS AF+ + L EL L N L+ + + + +L
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 375
Query: 176 LSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFAL 235
+SL +N + +P F++++ + + + +N+L+ LP +F L L
Sbjct: 376 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLG-IFDHLGKLC----------EL 424
Query: 236 SFGGNPLHCNCELLWLR--------RLSREDDLETCASPPLLTGR 272
NP C+ ++L LR RL D + C SP + G+
Sbjct: 425 RLYDNPWRCDSDILPLRNWLLLNQPRLG-TDTVPVCFSPANVRGQ 468
Score = 77.8 bits (190), Expect = 3e-14
Identities = 47/127 (37%), Positives = 69/127 (54%)
Query: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
EL L DN ++++ F+N+ L L LSRN ISFI+P AF L LR L L++N L +
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLH 174
++F L+NL ++ L NN+L + F +V L + L N LE +P + + L
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 422
Query: 175 TLSLDHN 181
L L N
Sbjct: 423 ELRLYDN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 106 bits (265), Expect = 7e-23
Identities = 69/220 (31%), Positives = 108/220 (49%), Gaps = 9/220 (4%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP C C S C ++ VP + + L++ + +T + F N+++L+
Sbjct: 25 CPSECTCSRASQ---VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIA 81
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L + +N +S ITP AF +L +LR L L +N+L + +F GL +L L+L++NQL I
Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
F L+EL L N+LE IP A + +V L L+L N + +I F HL +
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201
Query: 200 LDVTSNKLQKLPPDPL--FQRAQVLATS----GIISPSTF 233
L + N+L +P Q LA G++SP F
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLF 241
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/185 (31%), Positives = 89/185 (48%), Gaps = 6/185 (3%)
Query: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
EL+L N + I F ++ L L L +N+++ I+P F L NL+ L L NRLT I
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
Query: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLH 174
F GL NL L L NQ+ L+S F + L+ L LS N++ +P ++ L+
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272
Query: 175 TLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL--FQRAQVLATS----GII 228
L+L N + + G F + + L + N + LP + ++ QVL S I
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI 332
Query: 229 SPSTF 233
SP F
Sbjct: 333 SPGAF 337
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/225 (27%), Positives = 109/225 (48%), Gaps = 20/225 (8%)
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
L L++N ++ + F + L LTL N++ ++ F + NLR L L N ++ +
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHT 175
+++FS L L LIL+ NQ++ IS AF+ + L EL L N L+ + + + +L
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
Query: 176 LSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFAL 235
+SL +N + +P F++++ + + + +N+L+ LP +F L L
Sbjct: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLG-IFDHLGKLC----------EL 418
Query: 236 SFGGNPLHCNCELLWLR--------RLSREDDLETCASPPLLTGR 272
NP C+ ++L LR RL D + C SP + G+
Sbjct: 419 RLYDNPWRCDSDILPLRNWLLLNQPRLG-TDTVPVCFSPANVRGQ 462
Score = 77.8 bits (190), Expect = 3e-14
Identities = 47/127 (37%), Positives = 69/127 (54%)
Query: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
EL L DN ++++ F+N+ L L LSRN ISFI+P AF L LR L L++N L +
Sbjct: 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Query: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLH 174
++F L+NL ++ L NN+L + F +V L + L N LE +P + + L
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 416
Query: 175 TLSLDHN 181
L L N
Sbjct: 417 ELRLYDN 423
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 106 bits (264), Expect = 9e-23
Identities = 82/274 (29%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 15 VKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANM 74
V Q CP +C C + + C L VP NI R T L L N +T I + DFA +
Sbjct: 23 VAPQACPAQCSCSGSTVD----CHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGL 78
Query: 75 TSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQ 134
L L L N IS I AF DL+ L L LN N L +F G + L+ L L+ NQ
Sbjct: 79 RHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQ 138
Query: 135 LTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHL 194
+ I AF ++ L L YN + I A + L L+L++N I + +F+H+
Sbjct: 139 IQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM 198
Query: 195 HKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL----W 250
K+ TF L N L+C+C L W
Sbjct: 199 PKL---------------------------------RTFRLH--SNNLYCDCHLAWLSDW 223
Query: 251 LRRLSREDDLETCASPPLLTGRYFWSIPEEEFLC 284
LR+ R C P L G + + EF+C
Sbjct: 224 LRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVC 257
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/269 (26%), Positives = 112/269 (41%), Gaps = 67/269 (24%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP C C N C KGL +P N+ E+RL
Sbjct: 273 CPAACTCS----NNIVDCRGKGLTEIPTNLPETITEIRL--------------------- 307
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
+NTI I P AF+ + LR + L++N+++++ D F GL +L+ L+L N++T +
Sbjct: 308 ---EQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELP 364
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTR 199
+ F+ +F+L+ L L+ N + + DA + + +L+ LSL N + I KGTFS L +
Sbjct: 365 KSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQT 424
Query: 200 LDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDD 259
+ + NP C+C L WL +
Sbjct: 425 MHLAQ-----------------------------------NPFICDCHLKWLADYLHTNP 449
Query: 260 LET----CASPPLLTGRYFWSIPEEEFLC 284
+ET C SP L + I ++F C
Sbjct: 450 IETSGARCTSPRRLANKRIGQIKSKKFRC 478
Score = 75.1 bits (183), Expect = 2e-13
Identities = 52/197 (26%), Positives = 89/197 (45%), Gaps = 46/197 (23%)
Query: 99 RNLRALHLNSNRLTKITNDMFSGLSNLHHLIL---NNNQLTLISSTAFDDVFALEELDLS 155
R++ L+L+ N+ T + + LSN HL L +NN+++ +S+ +F ++ L L LS
Sbjct: 754 RDVTELYLDGNQFTLVPKE----LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILS 809
Query: 156 YNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
YN L IP + + SL LSL N I +P+G F+ L ++
Sbjct: 810 YNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSH---------------- 853
Query: 216 FQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWL----RRLSREDDLETCASPPLLTG 271
L+ G NPL+C+C + WL + +E + CA P +
Sbjct: 854 -------------------LAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMAD 894
Query: 272 RYFWSIPEEEFLCEPPL 288
+ + P ++F C+ P+
Sbjct: 895 KLLLTTPSKKFTCQGPV 911
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/140 (33%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
CP C C + C+ KGL +P I R EL L N T + K+ +N L
Sbjct: 727 CPTECTCL----DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP-KELSNYKHLTL 781
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
+ LS N IS ++ +F+++ L L L+ NRL I F GL +L L L+ N ++++
Sbjct: 782 IDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP 841
Query: 140 STAFDDVFALEELDLSYNNL 159
AF+D+ AL L + N L
Sbjct: 842 EGAFNDLSALSHLAIGANPL 861
Score = 70.5 bits (171), Expect = 5e-12
Identities = 46/163 (28%), Positives = 81/163 (49%), Gaps = 29/163 (17%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRL--------------------- 58
CP++C C+ + + C+ + L +P +I + T ELRL
Sbjct: 506 CPEKCRCEGTTVD----CSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR 561
Query: 59 ----ADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
++N +T+I+ F + + ++ L+ N + + F L +L+ L L SNR+T +
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCV 621
Query: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYN 157
ND F GLS++ L L +NQ+T ++ AFD + +L L+L N
Sbjct: 622 GNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 64.7 bits (156), Expect = 3e-10
Identities = 49/187 (26%), Positives = 81/187 (43%), Gaps = 16/187 (8%)
Query: 104 LHLNSNRLTKI-TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETI 162
L LN+N T + +F L L + +NN++T I AF+ + E+ L+ N LE +
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV 597
Query: 163 PWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVL 222
+ + SL TL L N I + +F L + L + N++ + P F L
Sbjct: 598 QHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPG-AFDTLHSL 656
Query: 223 ATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET----CASPPLLTGRYFWSIP 278
+T +++ NP +CNC L WL R+ + T C P L +
Sbjct: 657 STLNLLA----------NPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVA 706
Query: 279 EEEFLCE 285
++F C+
Sbjct: 707 IQDFTCD 713
>gi|153791466 AMIGO protein [Homo sapiens]
Length = 493
Score = 105 bits (262), Expect = 1e-22
Identities = 104/382 (27%), Positives = 173/382 (45%), Gaps = 59/382 (15%)
Query: 8 LFLIGIAVKAQI-CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNI 66
LF + A +A + CP C+C + N+ + C+K+ L VP ++ T L L+ N ++ +
Sbjct: 21 LFEVARAGRAVVSCPAACLC---ASNILS-CSKQQLPNVPHSLPSYTALLDLSHNNLSRL 76
Query: 67 KRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNL 125
+ + +T L L LS N ++FI+ AF+ + NLR L L+SN+L + +FS L L
Sbjct: 77 RAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVL 136
Query: 126 HHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDN 185
L+L NN + + AFDD+ L++L LS N + P + V++
Sbjct: 137 EVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKE---------------- 180
Query: 186 IPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCN 245
+ L K+T LD++SNKL+ LP P Q+ +G L NPL+C+
Sbjct: 181 -----GAKLPKLTLLDLSSNKLKNLPL-PDLQKLPAWIKNG--------LYLHNNPLNCD 226
Query: 246 CELLWL------RRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVL 299
CEL L R+LS D + Y + + + + ++ R
Sbjct: 227 CELYQLFSHWQYRQLSSVMDFQ--------EDLYCMNSKKLHNVFNLSFLNCGEYKERAW 278
Query: 300 E---GQRATLRCKARGDPEPAIHWISPEGKL----ISNATRSLVYDNGTLDILITTVKDT 352
E G ++C + + W++P + ++N T S+ D G+L V+D
Sbjct: 279 EAHLGDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKD-GSLLFQQVQVEDG 336
Query: 353 GAFTCIASNPAGEATQIVDLHI 374
G +TC A T V+L +
Sbjct: 337 GVYTCYAMGETFNETLSVELKV 358
>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
Length = 550
Score = 104 bits (259), Expect = 3e-22
Identities = 100/404 (24%), Positives = 169/404 (41%), Gaps = 47/404 (11%)
Query: 102 RALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLET 161
+ + + ++ L ++ F +S L +L LN N +++I A + + L EL L N L +
Sbjct: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
Query: 162 IPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPD-----PLF 216
+PW A L L L N ID +P+ L +T LD++SN+L + P +
Sbjct: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAY 177
Query: 217 QRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET--------CASPPL 268
Q+ + G S+ ++ NP C+C L L + + L C P
Sbjct: 178 QKCR-QPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLS 236
Query: 269 LTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG--K 326
G+ F E C P I+ + + + GQ TLRC A+ P P+I W P +
Sbjct: 237 KAGQLFHE--TELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWR 294
Query: 327 LISNATRSLVYDNGTLDILITT--VKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNST 384
T S D ++ I + D+G +TC+ASN G++ ++ LH+
Sbjct: 295 EFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHV-------QPA 347
Query: 385 NHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGI 444
+H PD S + S G+ + + V + T LL++ +
Sbjct: 348 QALHAPD-------------SLSIPSEGNAYID---LRVVKQTVHGILLEWLAVADTSKE 391
Query: 445 RMF--QIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCV 486
F I + + +V+ I P T+ V++L GT Y+ C+
Sbjct: 392 EWFTLYIASDEAFRKEVVH--IGPGINTYAVDDLLPGTKYEACL 433
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 103 bits (256), Expect = 7e-22
Identities = 85/308 (27%), Positives = 134/308 (43%), Gaps = 50/308 (16%)
Query: 52 RTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111
R +L L N + I+ F + SL L L RN IS +T AF L + LHL N L
Sbjct: 212 RLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL 271
Query: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171
++ + GL+ LH L L+NN + I + L EL LS+NNL + +++ ++
Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELS 331
Query: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGI---- 227
SL L L HN I +I +G F L + LD+ N++ D + + + S +
Sbjct: 332 SLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFG 391
Query: 228 -----ISPSTFA-------LSFGGNPLH------------------------CNCELLWL 251
++ F+ L+ GGN + C+C+L WL
Sbjct: 392 NKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWL 451
Query: 252 -----RRLSREDDLETCASPPLLTGRYFWSIPEEEFLCE----PPLITRHTHEMRVLEGQ 302
R+ + TCA P L G+ +S+P E F+C+ P +IT+ M ++ G+
Sbjct: 452 PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMV-GK 510
Query: 303 RATLRCKA 310
C A
Sbjct: 511 DIRFTCSA 518
Score = 71.6 bits (174), Expect = 2e-12
Identities = 99/417 (23%), Positives = 154/417 (36%), Gaps = 74/417 (17%)
Query: 29 LSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTIS 88
LS N +KG F ++ EL L+ N +T + + A ++SL L LS N+IS
Sbjct: 290 LSNNSIARIHRKGWSFC-----QKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSIS 344
Query: 89 FITPHAFADLRNLRALHLNSNRLTKITNDM---------------------------FSG 121
I AF LR+LR L L+ N ++ D FSG
Sbjct: 345 HIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSG 404
Query: 122 LSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNN------LETIPWDAVEKMVSL-- 173
L L HL L N + + AF + L+EL +S ++ L+ +P + +M+
Sbjct: 405 LEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFV 464
Query: 174 -----HTLSLDHNMIDNIPKGTF--SHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSG 226
H SL I ++P +F K + + + D F + A S
Sbjct: 465 TATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCS---AASS 521
Query: 227 IISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEP 286
SP TFA N + N ++ + +D E +L R E + C
Sbjct: 522 SSSPMTFAWK-KDNEVLTNADMENFVHVHAQDG-EVMEYTTILHLRQVTFGHEGRYQCVI 579
Query: 287 -------------------PLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKL 327
P T+ H++ + A L C A G P P I W G
Sbjct: 580 TNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTD 639
Query: 328 ISNATRSLVY---DNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLL 381
A ++ D+ I + D G ++C A N AG + L +++ P L+
Sbjct: 640 FPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLV 696
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/162 (31%), Positives = 83/162 (51%), Gaps = 2/162 (1%)
Query: 55 ELRLADNFVTNIKRKDFANMT-SLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTK 113
EL LA N + ++ F ++ SL+ L LS+N I+ + AF L L L LN NR+
Sbjct: 167 ELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRL 225
Query: 114 ITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSL 173
I F GL++L L L N ++ ++ AF + + L L YN+L + ++ + +L
Sbjct: 226 IEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTAL 285
Query: 174 HTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
H L L +N I I + +S K+ L ++ N L +L + L
Sbjct: 286 HQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESL 327
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/133 (30%), Positives = 69/133 (51%), Gaps = 2/133 (1%)
Query: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
L LS N +S I P F DL NL+ ++LN+N LT + + + + S++ L L +N++ +
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPS-LGAASSHVVSLFLQHNKIRSVE 131
Query: 140 STAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHK-MT 198
+ +LE LDLS NN+ + + L+L N I + G F L + +
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 199 RLDVTSNKLQKLP 211
L ++ N++ +LP
Sbjct: 192 TLRLSKNRITQLP 204
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 5/190 (2%)
Query: 31 PNLATLCAKKGLLFVPPNI---DRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTI 87
PNL + L P++ V L L N + +++ SL L LS N I
Sbjct: 92 PNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNI 151
Query: 88 SFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS-NLHHLILNNNQLTLISSTAFDDV 146
+ + F ++ L+L NR+ + F GLS +L L L+ N++T + AF +
Sbjct: 152 TEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KL 210
Query: 147 FALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNK 206
L +LDL+ N + I + + SL L L N I + G F L KM L + N
Sbjct: 211 PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNS 270
Query: 207 LQKLPPDPLF 216
L ++ L+
Sbjct: 271 LVEVNSGSLY 280
Score = 50.1 bits (118), Expect = 7e-06
Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 102 RALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLET 161
R+L+L+ N+L++I F L NL + LNNN+LT + S + L L +N + +
Sbjct: 71 RSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVV-SLFLQHNKIRS 129
Query: 162 IPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKL 210
+ ++ +SL L L N I + F H + L++ N++ L
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTL 178
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/80 (31%), Positives = 34/80 (42%)
Query: 285 EPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDI 344
E P + + V G+ L+CKA G+P P I W + L L DN L +
Sbjct: 691 ETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVV 750
Query: 345 LITTVKDTGAFTCIASNPAG 364
+D G +TC SN G
Sbjct: 751 QNVVAEDAGRYTCEMSNTLG 770
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 102 bits (254), Expect = 1e-21
Identities = 68/216 (31%), Positives = 109/216 (50%), Gaps = 24/216 (11%)
Query: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTV------------------------E 55
CP C CQ L+ C++ GL VP ++D T E
Sbjct: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
LRL+ N +++I + F+ + SL L L N + I A +L +L++L L++N ++ +
Sbjct: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
Query: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHT 175
F GLS+L HL L++N LT I A +++ AL+ + L+ N + IP A + + SL
Sbjct: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
Query: 176 LSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLP 211
L L +N I ++ +F LH + LD+ NKLQ+ P
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 51/219 (23%)
Query: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
L L DN +T I + N+ +L +TL+ N IS I +AF +L +L LHL++NR+ +
Sbjct: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
Query: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPW----------- 164
F GL NL L LN N+L A + L+EL NN++ IP
Sbjct: 227 THSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 285
Query: 165 -------------DAVEKMVSLHTLSLDHNM-----------------------IDNIPK 188
A + + LHTLSL+ M I +P
Sbjct: 286 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 345
Query: 189 GTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGI 227
G L ++ L+++ N++++LP R Q L G+
Sbjct: 346 GMCQQLPRLRVLELSHNQIEELPS---LHRCQKLEEIGL 381
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/162 (28%), Positives = 72/162 (44%), Gaps = 3/162 (1%)
Query: 52 RTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRL 111
R EL +N + I K F L + N I F+ AF L L L LN
Sbjct: 258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
Query: 112 TKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV 171
+ D+ G ++L L L + L+ S + L L+LS+N +E +P ++ +
Sbjct: 318 IQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ 374
Query: 172 SLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPD 213
L + L HN I I TFS L + LD++ N ++ + P+
Sbjct: 375 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/134 (32%), Positives = 63/134 (47%), Gaps = 7/134 (5%)
Query: 25 VCQILSPNLATLCAKKGLLFVPPNIDR--RTVELRLADNFVTNIKRKDFANMTSLVDLTL 82
+CQ L P L L + P++ R + E+ L N + I F+ ++SL L L
Sbjct: 347 MCQQL-PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDL 405
Query: 83 SRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTA 142
S N I I P AF+ L +L L L N+LT + +GL L HL L N L L + +
Sbjct: 406 SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN-LALSQAFS 461
Query: 143 FDDVFALEELDLSY 156
D L L++ Y
Sbjct: 462 KDSFPKLRILEVPY 475
Score = 35.4 bits (80), Expect = 0.19
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 152 LDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLP 211
LDLS NNL + + L L L N + +IP FS L+ + L + +N+L +P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 212 PDPLFQ 217
+ L++
Sbjct: 131 AEALWE 136
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 102 bits (253), Expect = 2e-21
Identities = 62/187 (33%), Positives = 95/187 (50%), Gaps = 1/187 (0%)
Query: 25 VCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSR 84
VCQ+ + C GL +P N TV L L N ++ I + + SLV L L
Sbjct: 35 VCQLCTGRQIN-CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDN 93
Query: 85 NTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFD 144
+ I ++ P AF LR+L L LN+N + ++ +F GL NL +L L NQ++ + F+
Sbjct: 94 SNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFN 153
Query: 145 DVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTS 204
D+ +++ L+L N L + MV+L L L +N I I + F HL + L + S
Sbjct: 154 DLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGS 213
Query: 205 NKLQKLP 211
N L K+P
Sbjct: 214 NNLTKVP 220
Score = 90.5 bits (223), Expect = 5e-18
Identities = 73/249 (29%), Positives = 106/249 (42%), Gaps = 20/249 (8%)
Query: 44 FVPPNIDRRTVE---LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRN 100
FVP + V L L N +T + F M +L L LS N I I+ F L N
Sbjct: 146 FVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLEN 205
Query: 101 LRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLE 160
L L+L SN LTK+ ++ F L +L L L++N + I AF + LE L L + +
Sbjct: 206 LACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIR 265
Query: 161 TIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQ 220
+ D + +L L L HN ++N+ TFS L + L + N++ + D
Sbjct: 266 NVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGA 325
Query: 221 VLATSG------------IISP--STFALSFGGNPLHCNCELLWLRRLSREDDLET---C 263
L ++ P S L NP CNC+LL LR + C
Sbjct: 326 SLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYC 385
Query: 264 ASPPLLTGR 272
+PP + GR
Sbjct: 386 QNPPSMRGR 394
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,467,318
Number of Sequences: 37866
Number of extensions: 1150851
Number of successful extensions: 8804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 336
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 4450
Number of HSP's gapped (non-prelim): 2816
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.