Guide to the Human Genome
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Search of human proteins with 30795231

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
         (227 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30795231 brain abundant, membrane attached signal protein 1 [...   445   e-125
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     85   6e-17
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              79   3e-15
gi|153070260 myristoylated alanine-rich protein kinase C substra...    75   5e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    75   6e-14
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    74   1e-13
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    74   1e-13
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    74   1e-13
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    74   1e-13
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    74   1e-13
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    74   1e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    74   1e-13
gi|33286446 opioid growth factor receptor [Homo sapiens]               68   7e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    68   7e-12
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    68   7e-12
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    66   2e-11
gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]     66   2e-11
gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]       66   2e-11
gi|210032580 SET domain containing 1B [Homo sapiens]                   65   4e-11
gi|163965366 nascent polypeptide-associated complex alpha subuni...    65   4e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   63   2e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   63   2e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   63   2e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    63   2e-10
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    63   2e-10
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          62   3e-10
gi|42518068 trans-golgi network protein 2 [Homo sapiens]               62   3e-10
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       62   4e-10
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora...    60   2e-09
gi|157738619 smoothelin-like 1 [Homo sapiens]                          60   2e-09

>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score =  445 bits (1144), Expect = e-125
 Identities = 227/227 (100%), Positives = 227/227 (100%)

Query: 1   MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
           MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ
Sbjct: 1   MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60

Query: 61  DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
           DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP
Sbjct: 61  DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
           KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA
Sbjct: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180

Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE
Sbjct: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 84.7 bits (208), Expect = 6e-17
 Identities = 64/210 (30%), Positives = 95/210 (45%), Gaps = 14/210 (6%)

Query: 20  KEKDKKAEGAATEEEGTPKESE--------PQAAAEPAEAKEGKEKPDQDAEGKAEEKEG 71
           +EK+ K E    EE G  +E+E        P A    +  KE K    ++A+  AE K  
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQA-APGPAAGGEAPK--AAEAAA 127
           EK+ A +  E    E  K+    EAK+ P  K+PE+E+A +P      E  K  A E A 
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593

Query: 128 APAESAAPAAGEEPSKEEGE-PKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKET 186
           +PAE+ +P   + P KEE + P + ++P    A+      +P     P   EA    K  
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653

Query: 187 PAATEAPSSTPKAQGPA-ASAEEPKPVEAP 215
               E   S  KA+ P  A A+ P+  ++P
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683



 Score = 80.9 bits (198), Expect = 8e-16
 Identities = 70/224 (31%), Positives = 112/224 (50%), Gaps = 26/224 (11%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK 73
           V +E  +E++K+A+    EEEG  +E   +  AE  E +      ++ A  + E K   K
Sbjct: 466 VTEEVTEEEEKEAK----EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521

Query: 74  DAAAAKEEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
           + A +  EA   E E+ +  AE K+ E  K+P +E+A   P A  ++P+  E A +PAE 
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA--KSPE-KEEAKSPAEV 578

Query: 133 AAPAAGEEPSKEE----GEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-APSSKETP 187
            +P   + P+KEE     E K  E   +P  +E KS   PA    P   EA +P+  ++P
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS---PAEAKSPVKEEAKSPAEVKSP 635

Query: 188 AATEAPS-----STPKAQGP----AASAEEPK-PVEAPAANSDQ 221
              ++P+     S  KA+ P    A S E+ K PV+A A + ++
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679



 Score = 77.8 bits (190), Expect = 7e-15
 Identities = 70/214 (32%), Positives = 101/214 (47%), Gaps = 24/214 (11%)

Query: 17  EKAKEKDKKAEGAATEEEGTPKES---EPQAAAEPAEAKE-------GKEKPDQDAEGKA 66
           E+A   +K+A+    EE  +P E+   E + A  PAE K         KE+     E K+
Sbjct: 507 EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566

Query: 67  EEKEGEKDAAAAK--EEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAA 123
            EKE  K  A  K  E+A     E+ +  AEAK+ E  K+P +E+ A  PA      K  
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE-AKSPAEAKSPVK-- 623

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-APS 182
           E A +PAE  +P   + P+KEE   K  E   +P  +E KS   P     P  +EA +P 
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEA--KSPEKAKSPEKEEAKS---PEKAKSPVKAEAKSPE 678

Query: 183 SKETPAATEAPSSTPKAQGPA-ASAEEPKPVEAP 215
             ++P   EA  S  KA+ P    A+ P+  ++P
Sbjct: 679 KAKSPVKAEA-KSPEKAKSPVKEEAKSPEKAKSP 711



 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 71/231 (30%), Positives = 107/231 (46%), Gaps = 32/231 (13%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
           K++EK K  E   +E+E    E + +      E  E +EK  ++ EGK EE+ GE++ A 
Sbjct: 439 KSEEKIKVVE--KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK-EEEGGEEEEAE 495

Query: 78  AKEEAPKAEPEKTEGAAEAKAEPP-----------KAPEQEQA-APGPAAGGEAPK--AA 123
             EE  K+ P +   + E +A+ P           K+PE+E+A +P      E  K  A 
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---APASDSKPGSSEA- 179
           E A +P E+ +P   +E +K   E K  E   +PA +E KS     +P     P   EA 
Sbjct: 556 EEAKSPPEAKSPE--KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613

Query: 180 APSSKETPAATEAPS-----STPKAQGP----AASAEEPKPVEAPAANSDQ 221
           +P+  ++P   EA S     S  KA+ P    A S E+ K  E   A S +
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664



 Score = 73.6 bits (179), Expect = 1e-13
 Identities = 64/237 (27%), Positives = 104/237 (43%), Gaps = 19/237 (8%)

Query: 4   KLSKKKKGYNVNDEKAKEKDK---KAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
           K  +K++  +  + K+ EK K   K E  +  E  +P++ E ++ AE    ++ K    +
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590

Query: 61  DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA-------EPPKAPEQEQAAPGP 113
           +A+  AE K  EK  +  KEEA      K+    EAK+       E  K+P +E+A    
Sbjct: 591 EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650

Query: 114 AAGG---EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPAS 170
            A     E  K+ E A +P ++ A +  +  S  + E K  E   +P  +E KS   P  
Sbjct: 651 KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS---PEK 707

Query: 171 DSKPGSSEA-APSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
              P   EA +P   ++P   EA   TP+        E   P +A +    +T+ VK
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEA--KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762



 Score = 73.6 bits (179), Expect = 1e-13
 Identities = 74/238 (31%), Positives = 95/238 (39%), Gaps = 38/238 (15%)

Query: 17  EKAKEKDKKAEGAAT---EEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK 73
           EKAK  D K+  A T   EE  +P +  P+ A  P      KE+     + K+  KE   
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV-----KEEVKSPEKAKSPLKE--- 805

Query: 74  DAAAAKEEAPKAEPEKTEGAAEAK------AEPPKAPEQEQAAPGP------------AA 115
           DA A ++E PK E  K+    E K       EPPK  E+E+A   P            A 
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865

Query: 116 GGEAPK-AAEAAAAPAESAAPAAGEEPSKEEGEPKK---TEAPAAPAAQETKSDGAP--- 168
             EAPK   E    PA      +  E  KEE E KK   T    APA  E K D  P   
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925

Query: 169 --ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVT 224
              +  +P  ++A   SK       AP      +  A   EE    EA A   D+T++
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 66/216 (30%), Positives = 94/216 (43%), Gaps = 26/216 (12%)

Query: 24  KKAEGAATEEEGTPKESE-PQAAAEPA--EAK---EGKEKPDQDAEGKAEEKEGEKDAAA 77
           +KA+  A EE  +P E++ P+ A  P   EAK   E K    ++A+  AE K  EK  + 
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 78  AKEEAPKAE----PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--E 131
            KEEA   E    PEK E  +  KA+ P   E +      +      K+ E A +P   E
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701

Query: 132 SAAPAAGEEPSKEEGE-PKKTEAPA-----------APAAQETKSDGAPASDSKPGSSEA 179
           + +P   + P KEE + P+K ++P            +P  +E KS     S  K  + + 
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761

Query: 180 APSSKETPAATEAPSSTPKAQGPAAS--AEEPKPVE 213
                +TPA  EA S   K    A S   EE K  E
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797



 Score = 68.6 bits (166), Expect = 4e-12
 Identities = 72/261 (27%), Positives = 104/261 (39%), Gaps = 40/261 (15%)

Query: 4   KLSKKKKGYNVNDEKAKEKDK---KAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEK 57
           K  +K K     + K+ EK K   KAE  + E+  +P + E   P+ A  P + +E K  
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKSP 719

Query: 58  PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG 117
               +  K E K  EK  +  KEEA    PEK +   +AK    K+PE +  A   A   
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKS--PEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777

Query: 118 -------------EAPKAAEAAAAPAESAAPAAGEE---------PSKEEGEPKKTEAPA 155
                        E  K+ E A +P +  A A  +E         P KEE +P++ +   
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837

Query: 156 AP-AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAAS--------A 206
            P  A+E K+   P ++ K  S +     KE P         P  + P  S        A
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897

Query: 207 EEPKPVEAPAANSDQTVTVKE 227
           E+ K V  P   +   V VKE
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKE 918



 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 61/228 (26%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 4    KLSKKKKGYNVNDEKAKEKD---KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
            K  +K K     D KA EK+   K+   +  +EE  P+E + +   + AE ++    P  
Sbjct: 794  KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP-- 851

Query: 61   DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
                K EEK+  K   A K+EAPK + E+ +  A  K +  K   +++ A          
Sbjct: 852  ----KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907

Query: 121  KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP--------AAPAAQETKSDGAPASDS 172
            K A A     E A P    E +K+E +  K + P        AAP  ++TK + A   + 
Sbjct: 908  KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967

Query: 173  KPGSSEAA----------PSSKETPAATEAPSSTPKAQGPAASAEEPK 210
            KP +   A          PS  +   A ++ S+  K   P   A E K
Sbjct: 968  KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 66/226 (29%), Positives = 97/226 (42%), Gaps = 30/226 (13%)

Query: 20  KEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAA 76
           +E    AE  + E+  +P + E   P+ A  P E +E K      +  KAE K  EK  +
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP-EKEEAKSPEKAKSPVKAEAKSPEKAKS 682

Query: 77  AAKEEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESA 133
             K EA   E  K+    EAK+ E  K+P +E+A           K+ E A +P   E+ 
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA-----------KSPEKAKSPVKEEAK 731

Query: 134 APAAGEEPSKEEGE-PKKTEAPAAPAAQETKSDGA--PASDSKPGSSEAAPSSKETPAAT 190
            P   + P KEE + P+K ++P      + KS  A  PA +     ++  P   ++P   
Sbjct: 732 TPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE 791

Query: 191 EAPS-----STPKAQGPAASAEEPK--PVEAPAANSD--QTVTVKE 227
           E  S     S  K    A   E PK   V++P    +  Q V VKE
Sbjct: 792 EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 41/150 (27%), Positives = 63/150 (42%), Gaps = 15/150 (10%)

Query: 7    KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
            +K K   V  +K + +DKK     T E+  P + E +  A+P E  E  +K   DA+ K 
Sbjct: 883  EKPKESKVEAKKEEAEDKKK--VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 67   EEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
              K  EK     KE AP+ +        + K E  K PE++      A   +   + E +
Sbjct: 941  PSKPAEK-----KEAAPEKK--------DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPS 987

Query: 127  AAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
               AE A  ++  +    +   K TE  AA
Sbjct: 988  KPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 8/103 (7%)

Query: 16   DEKAKEKD----KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG 71
            D K KEK     K+ + A  +E   P E + +AA E  + KE K K  ++ + K E K  
Sbjct: 919  DAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-EAAPEKKDTKEEKAKKPEE-KPKTEAKAK 976

Query: 72   EKDAAAAKEEA-PKAEP-EKTEGAAEAKAEPPKAPEQEQAAPG 112
            E D   +KE + PKAE  EK+    +  ++PP+   +++AA G
Sbjct: 977  EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 47/170 (27%), Positives = 68/170 (40%), Gaps = 33/170 (19%)

Query: 65  KAEEK-----EGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGE 118
           K+EEK     + EK+    +E+  + +  E+     E +A+  +  E+E      A GGE
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
                E  + PAE AA      P KE   P K EA +            PA    P   E
Sbjct: 499 E----ETKSPPAEEAA-----SPEKEAKSPVKEEAKS------------PAEAKSPEKEE 537

Query: 179 A-APSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           A +P+  ++P   ++P     A+  A S  E K  E   A S   V   E
Sbjct: 538 AKSPAEVKSPEKAKSP-----AKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 79.0 bits (193), Expect = 3e-15
 Identities = 64/199 (32%), Positives = 93/199 (46%), Gaps = 14/199 (7%)

Query: 32   EEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTE 91
            + +G      P+A  E     EG E P+  AEG A+E EGE    +   EAP+AE     
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPE--AEGDAQEAEGEAQPESEDVEAPEAE----- 1880

Query: 92   GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES--AAPAAGE-EPSKEEGEP 148
            G A+ ++E  + PE E      + G EAP+A + A    ES  A    GE EP  E  E 
Sbjct: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940

Query: 149  KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
            ++ E  A  A  +T+ + +   +S+    EA P S++   A E    T +A+G A    E
Sbjct: 1941 QEAEEAAQEAEGQTQPE-SEVIESQEAEEEAQPESEDV-EALEVEVETQEAEGEA--QPE 1996

Query: 209  PKPVEAPAANSDQTVTVKE 227
             + VEAP A  +     +E
Sbjct: 1997 SEDVEAPEAEGEMQEAEEE 2015



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 15/209 (7%)

Query: 16   DEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAKEGKEKPDQDA-EGKAEEKEGE 72
            +++A+ + +  E   TE E  P+   +E Q A E A+  EG+ +P+ +  E +  E+E +
Sbjct: 1912 EKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ 1971

Query: 73   KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
             ++   +    + E ++ EG A+ ++E  +APE E          EA + A+  +   E+
Sbjct: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQ------EAEEEAQPESDGVEA 2025

Query: 133  AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
               + GEE  + EGE +KTE  A P     +SDG  A +++  + EA    +E       
Sbjct: 2026 QPKSEGEEAQEVEGETQKTEGDAQP-----ESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080

Query: 193  PSSTPKAQGPAASAE-EPKPVEAPAANSD 220
             S    AQ     A+ E + VEAP A  +
Sbjct: 2081 ESEDVDAQEAEGEAQPESEGVEAPEAEGE 2109



 Score = 74.3 bits (181), Expect = 8e-14
 Identities = 75/229 (32%), Positives = 107/229 (46%), Gaps = 31/229 (13%)

Query: 16   DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
            +E+A+ + +  E    E E    E E Q  +E  EA E  E   Q+AE   EE + E D 
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEA-EGEMQEAE---EEAQPESDG 2022

Query: 76   AAAK-----EEAPKAEPE--KTEGAAEAKA---EPPKAPEQEQAAPGPA--AGGEAPKAA 123
              A+     EEA + E E  KTEG A+ ++   E P+A E+ Q A G    A GEA   +
Sbjct: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082

Query: 124  E---AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPAS---DSKPGSS 177
            E   A  A  E+   + G E  + EGE +K E   AP   ET+ +  P S   ++     
Sbjct: 2083 EDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP---ETEGEAQPESEGIEAPEAEG 2139

Query: 178  EAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP----VEAPAANSD 220
            EA P S+   A      + P+++G  A  + EE +P    VEAP A  +
Sbjct: 2140 EAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188



 Score = 72.8 bits (177), Expect = 2e-13
 Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 28/217 (12%)

Query: 17   EKAKEKDKKAEGAATEE----EGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKA 66
            ++ + + +K EG A  E    E    E E Q A    +  EG+  P+      Q+AEG+A
Sbjct: 2035 QEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEA 2094

Query: 67   EEKEGEKDAAAAKEEAPKA---EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
            + +    +A  A+ EA KA   E  +TEG A+ ++E  +APE E  A   + G EA + A
Sbjct: 2095 QPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEA-QDA 2153

Query: 124  EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
            E  A P ES    A E   + + E +  EAP A    + +S+G  A +++    EA P  
Sbjct: 2154 EGEAQP-ESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE---GEAQPEL 2209

Query: 184  KETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
            +      EAP +  +AQ       EP+ VE P A  +
Sbjct: 2210 E----GVEAPEAEEEAQ------PEPEGVETPEAEGE 2236



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 65/208 (31%), Positives = 98/208 (47%), Gaps = 23/208 (11%)

Query: 14   VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKAE 67
            V   +A+ + +KAEG    E  T  E++P++    A   EG+ +P+      QDAEG+A+
Sbjct: 2101 VEAPEAEGEAQKAEGIEAPE--TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ 2158

Query: 68   EKEGEKDAAAAKEEAPK----AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
             +    +A  A+EEA       E  + EG A+ ++E  +APE E  A     G EAP+A 
Sbjct: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE 2218

Query: 124  EAAAAPAE--SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
            E A    E      A GE   + EGE   T+     + Q +  DG   S+    SS   P
Sbjct: 2219 EEAQPEPEGVETPEAEGEAQPESEGE---TQGEKKGSPQVSLGDG--QSEEASESSSPVP 2273

Query: 182  SSKETPAAT---EAPSSTPKAQ-GPAAS 205
              + TP  +   + P   P +Q GP++S
Sbjct: 2274 EDRPTPPPSPGGDTPHQRPGSQTGPSSS 2301



 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 69/242 (28%), Positives = 104/242 (42%), Gaps = 45/242 (18%)

Query: 14   VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK-----EGKEKPD-----QDAE 63
            V   +A+E+ ++AEG   E EG          A+ AE +     EG E P+     Q AE
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114

Query: 64   G-KAEEKEGEKDAAAAKEEAPKAEPEK-----------TEGAAEAKAEPPKAPEQEQAAP 111
            G +A E EGE    +   EAP+AE E             EG A+ ++E  +A E E+ A 
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174

Query: 112  GPAAGGEAPKAAEAAAAPAES--AAPAAGEEPSKEEG------------EPKKTEAPAAP 157
                G EAP+A   A   +E   A  A GE   + EG            EP+  E P A 
Sbjct: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE 2234

Query: 158  AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
               + +S+G    + K GS + +    ++  A+E+ S  P+        + P P  +P  
Sbjct: 2235 GEAQPESEGETQGEKK-GSPQVSLGDGQSEEASESSSPVPE--------DRPTPPPSPGG 2285

Query: 218  NS 219
            ++
Sbjct: 2286 DT 2287



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 63/215 (29%), Positives = 90/215 (41%), Gaps = 33/215 (15%)

Query: 24   KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA---EGKAEEKEGEKDAAAAKE 80
            ++AE AA E EG  +       ++ AE +   E  D +A   E + +E EGE    +   
Sbjct: 1941 QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDV 2000

Query: 81   EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES-------- 132
            EAP+AE E  E   EA+      PE +     P + GE  +  E      E         
Sbjct: 2001 EAPEAEGEMQEAEEEAQ------PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054

Query: 133  -AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
              AP A EE  + EGE ++ E  A P +++         D++    EA P S E   A E
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDV--------DAQEAEGEAQPES-EGVEAPE 2105

Query: 192  APSSTPKAQG---PAASAE---EPKPVEAPAANSD 220
            A     KA+G   P    E   E + +EAP A  +
Sbjct: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 58/215 (26%), Positives = 95/215 (44%), Gaps = 11/215 (5%)

Query: 16   DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK-EGK---EKPDQDAEGKAEEKEG 71
            D+  K  + + +  A E EG    SE  A +E  EA+ EG+   E+ +   +G   E   
Sbjct: 1755 DKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNL 1814

Query: 72   EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
            + +AAA  ++ P  + +  EG    +AE    PE E     P A G+A +A E  A P E
Sbjct: 1815 QGEAAAGGDQDP-GQSDGAEGIEAPEAEGEAQPESE-GVEAPEAEGDAQEA-EGEAQP-E 1870

Query: 132  SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
            S    A E   + + E +  E P A    + +S+GA A +++    EA P ++   A   
Sbjct: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE---KEAQPETESVEALET 1927

Query: 192  APSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
                 P+++G  A   E    EA      ++  ++
Sbjct: 1928 EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 67/216 (31%), Positives = 94/216 (43%), Gaps = 26/216 (12%)

Query: 19   AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAA 78
            A+E + +A+  + + E    E E Q  +E  E  E + +   ++EG AE  E EK+A   
Sbjct: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG-AEAPEAEKEA--- 1915

Query: 79   KEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG 138
            + E    E  +TEG  E ++E  +A E E+AA   A G   P++    +  AE  A    
Sbjct: 1916 QPETESVEALETEGEDEPESEGAEAQEAEEAAQ-EAEGQTQPESEVIESQEAEEEAQPES 1974

Query: 139  E---------EPSKEEG----EPKKTEAPAAPA-AQETKSDGAPASDSKPGSSEAAPSSK 184
            E         E  + EG    E +  EAP A    QE + +  P SD      EA P S 
Sbjct: 1975 EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESD----GVEAQPKS- 2029

Query: 185  ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
            E   A E    T K +G A    E   VEAP A  +
Sbjct: 2030 EGEEAQEVEGETQKTEGDA--QPESDGVEAPEAEEE 2063



 Score = 58.5 bits (140), Expect = 4e-09
 Identities = 50/173 (28%), Positives = 74/173 (42%), Gaps = 11/173 (6%)

Query: 18   KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG-KAEEKEGEKDAA 76
            +A E + +A+  +   E    E E Q  +E  EA+E +E+   + EG +A E EGE    
Sbjct: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192

Query: 77   AAKEEAPKAEPE---KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA 133
            +   EAP+AE E   + EG    +AE    PE E     P A GEA   +E      +  
Sbjct: 2193 SEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE-GVETPEAEGEAQPESEGETQGEKKG 2251

Query: 134  APAAG-----EEPSKEEGEPKKTEAPAAPAAQETKSDGA-PASDSKPGSSEAA 180
            +P         E + E   P   + P  P +    +    P S + P SS A+
Sbjct: 2252 SPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 52/186 (27%), Positives = 71/186 (38%), Gaps = 26/186 (13%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
            G+   + +G    D +  E   ++EG   +E     E E Q   E  EA E + +   ++
Sbjct: 2139 GEAQPESEGVEAQDAEG-EAQPESEGIEAQEA----EEEAQPELEGVEAPEAEGEAQPES 2193

Query: 63   EG-KAEEKEGEKDAAAAKEEAPKAEPE---KTEGAAEAKAEPPKAPEQEQAAPGPAAGGE 118
            EG +A E EGE        EAP+AE E   + EG    +AE    PE E    G      
Sbjct: 2194 EGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQG------ 2247

Query: 119  APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
                 E   +P  S      EE S E   P   + P  P      S G      +PGS  
Sbjct: 2248 -----EKKGSPQVSLGDGQSEEAS-ESSSPVPEDRPTPP-----PSPGGDTPHQRPGSQT 2296

Query: 179  AAPSSK 184
               SS+
Sbjct: 2297 GPSSSR 2302



 Score = 52.0 bits (123), Expect = 4e-07
 Identities = 53/220 (24%), Positives = 87/220 (39%), Gaps = 13/220 (5%)

Query: 1    MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
            MG      K+ +++     +++ +  +G A E       ++P +      A+ G      
Sbjct: 1676 MGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735

Query: 61   DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
               G  E ++GE      +++ PK    + EG A A+    K    E +A      GEA 
Sbjct: 1736 QGPGVDEGEDGEGSQRLNRDKDPKL--GEAEGDAMAQEREGKTHNSETSAGSEL--GEAE 1791

Query: 121  KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
            +  E  +   E+    +G E + +       EA A       +SDGA   ++     EA 
Sbjct: 1792 QEGEGISERGETGGQGSGHEDNLQ------GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845

Query: 181  PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
            P S E   A EA     +A+G A    E + VEAP A  +
Sbjct: 1846 PES-EGVEAPEAEGDAQEAEGEA--QPESEDVEAPEAEGE 1882



 Score = 52.0 bits (123), Expect = 4e-07
 Identities = 47/214 (21%), Positives = 84/214 (39%), Gaps = 17/214 (7%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATE-------EEGTPKESEPQAAAEPAEAKEGKE 56
            ++ ++K+G + + E A+    K     T        E G           +  E  EG +
Sbjct: 1691 QILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQ 1750

Query: 57   KPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAG 116
            + ++D + K  E EG+   A A+E   K    +T   +E         E EQ   G +  
Sbjct: 1751 RLNRDKDPKLGEAEGD---AMAQEREGKTHNSETSAGSE-------LGEAEQEGEGISER 1800

Query: 117  GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS 176
            GE            +  A A G++   +    +  EAP A    + +S+G  A +++  +
Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860

Query: 177  SEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
             EA   ++      EAP +  +AQ  +   E P+
Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 49/188 (26%), Positives = 78/188 (41%), Gaps = 11/188 (5%)

Query: 16   DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
            +E   E+D + + A++  E    E+  Q   +  E KEG E   +  + +A + E  K  
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLA-ENTVQEEVQLEETKEGTE--GEGLQEEAVQLEETKTE 1328

Query: 76   AAAKEEAPKAEPEK-TEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
               +EE  + E  K TEG  E + E     E+ +   G     E  +  E    P     
Sbjct: 1329 EGLQEEGVQLEETKETEG--EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386

Query: 135  PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----AAPSSKETPA-A 189
              A EE  KEEG P++        ++ +  DG  + +  P   E    A+ S++  PA  
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446

Query: 190  TEAPSSTP 197
            TE P+  P
Sbjct: 1447 TEEPTEPP 1454



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 51/202 (25%), Positives = 76/202 (37%), Gaps = 34/202 (16%)

Query: 21   EKDKKAEGAATEEEGTPKESEPQAAAEP-----AEAKEGKEKPDQDAEGKAEEKEGEKDA 75
            E+ K+ EG   +EE    E   +   E       + +E KE P+   +G+A E EG K+ 
Sbjct: 1339 EETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE-EGLKEE 1397

Query: 76   AAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAP 135
               +E +   +      + + K      P QE+ A      G A  +AE          P
Sbjct: 1398 GLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEA------GRASASAEPC--------P 1443

Query: 136  AAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
            A G E   E  EP    +   P+A E +S            S+  P  ++ P AT     
Sbjct: 1444 AEGTE---EPTEPPSHLSETDPSASERQS-----------GSQLEPGLEKPPGATMMGQE 1489

Query: 196  TPKAQGPAASAEEPKPVEAPAA 217
              +AQ    +AE    V   AA
Sbjct: 1490 HTQAQPTQGAAERSSSVACSAA 1511



 Score = 42.0 bits (97), Expect = 4e-04
 Identities = 47/192 (24%), Positives = 73/192 (38%), Gaps = 31/192 (16%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           +E+  +   +     G P+ SEP+++  P   ++G +     A+  AE K G        
Sbjct: 445 RERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAG-------- 496

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAG 138
                           +  E P          GP  GG   P+A     A ++S+A    
Sbjct: 497 ---------------GSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGS 541

Query: 139 EEPSKE-EGEPK--KTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
            E S E  G P+    +A A  + QE    G PAS   P  S ++  S +  A T+    
Sbjct: 542 HEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS---PALSLSSLRSDDLQAETQG-QG 597

Query: 196 TPKAQGPAASAE 207
           T +A G A + E
Sbjct: 598 TEQATGAAVTRE 609



 Score = 32.3 bits (72), Expect = 0.34
 Identities = 36/173 (20%), Positives = 67/173 (38%), Gaps = 21/173 (12%)

Query: 6    SKKKKGYNVNDEKAK-EKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQD 61
            +K+ +G    +E+A+ E+ ++  G   +EEG   E     P+   +    +EG ++    
Sbjct: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP 1400

Query: 62   AEGKAEEKE-----------GEKDAAAAKEEAPKA----EPEKTEGAAEAKAEPPKAPEQ 106
             EG    +E            ++D    +EEA +A    EP   EG  E    P    E 
Sbjct: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET 1460

Query: 107  EQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAA 159
            + +A    +G +     E               +P+  +G  +++ + A  AA
Sbjct: 1461 DPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPT--QGAAERSSSVACSAA 1511



 Score = 29.6 bits (65), Expect = 2.2
 Identities = 40/183 (21%), Positives = 65/183 (35%), Gaps = 35/183 (19%)

Query: 35   GTPKESEPQAAAEPAE------AKEGKEKPDQDAEGKAEEK--------EGEKDAAAAKE 80
            G+P+E   Q    P+       ++         + G +EEK        +G+++A+    
Sbjct: 886  GSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSP 945

Query: 81   EA-PKAEPEKTEGAAEAKAEPPKAP-----EQEQAAPGPAAGG-EAPKAAEAAAAPAESA 133
             + P++ PE      E     P+ P     E      G A GG   P+         E  
Sbjct: 946  SSLPRSSPEAV--VREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGL 1003

Query: 134  APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA--PASDSKPGSSEAAPSSKETPAATE 191
               A       EG+P           Q+ + +GA   +SD+ P S E  P        +E
Sbjct: 1004 GEPAQAGQQSLEGDP----------GQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSE 1053

Query: 192  APS 194
            AP+
Sbjct: 1054 APA 1056


>gi|153070260 myristoylated alanine-rich protein kinase C substrate
           [Homo sapiens]
          Length = 332

 Score = 75.1 bits (183), Expect = 5e-14
 Identities = 80/234 (34%), Positives = 103/234 (44%), Gaps = 47/234 (20%)

Query: 21  EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK------PDQDAEGKAEE------ 68
           EK+  AEG A E  G+P  +E +AA+  +     K +      P  +   K ++      
Sbjct: 104 EKEAPAEGEAAEP-GSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKK 162

Query: 69  ---------KEGEKDAAAAKE-EAPKAEPEKTE---GAAEAKAEPPKAPEQEQAAPGP-- 113
                    K+ +K+A    E EAP AE  K E   GAA A AE   A  ++ AAPG   
Sbjct: 163 SFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEA 222

Query: 114 ------AAGGEAPKAAEAAAAPAESAAPA-----AGEEPSKEEGEPKKTEAPAAPAAQET 162
                 AAGG+  +A    AA A    PA     A EEPSK E E K  EA A+ AA E 
Sbjct: 223 AAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVE-EKKAEEAGASAAACEA 281

Query: 163 KSDGAPASDSKPGSSEAAPSSKETPAATEAPS--STPKAQGPAASAEEPKPVEA 214
            S   P +   P   EAAP+  E PAA  A S  + P  +     + E  P EA
Sbjct: 282 PSAAGPGA---PPEQEAAPA--EEPAAAAASSACAAPSQEAQPECSPEAPPAEA 330



 Score = 68.6 bits (166), Expect = 4e-12
 Identities = 79/269 (29%), Positives = 112/269 (41%), Gaps = 51/269 (18%)

Query: 1   MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKES---EPQAAAEPAEAKEGKEK 57
           MG + SK         E A E+  +A  A++  +   +E+   +    A PA A+ G  K
Sbjct: 1   MGAQFSKTA----AKGEAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGA-K 55

Query: 58  PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAP-EQEQAAPGPAAG 116
            +  A G A   + E+ AAA    A  +  EK E AA A  E   +P E+E  A G AA 
Sbjct: 56  EELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAE 115

Query: 117 GEAPKAAEAAAAPAES--AAPAA--GEEPS------------------------------ 142
             +P AAE  AA A S  ++P A  G  PS                              
Sbjct: 116 PGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNK 175

Query: 143 KEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----AAPSSKETPAATEAPSSTPK 198
           KE GE  + EAPAA   ++  + GA A+ ++ G++     AAP  +       A    P+
Sbjct: 176 KEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQ 235

Query: 199 AQGPAASAEEPKPVEAPAANSDQTVTVKE 227
              P  +A  P   E P A SD+T   +E
Sbjct: 236 EAKPQEAAVAP---EKPPA-SDETKAAEE 260



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 64/189 (33%), Positives = 84/189 (44%), Gaps = 28/189 (14%)

Query: 4   KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAE 63
           K S K  G++    K KE  +  E  A   EG   E+   AAA  AEA  G    +Q A 
Sbjct: 161 KKSFKLSGFSFKKNK-KEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEA--GAASGEQAAA 217

Query: 64  GKAEEKEGEKDAAA-----AKEEAPKAEPEKTEGAAEAKA--EPPKAPEQE-QAAPGPAA 115
              E   GE+ AA      AK +     PEK   + E KA  EP K  E++ + A   AA
Sbjct: 218 PGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAA 277

Query: 116 GGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG 175
             EAP AA   A P + AAPA               E PAA AA  + +  AP+ +++P 
Sbjct: 278 ACEAPSAAGPGAPPEQEAAPA---------------EEPAAAAA--SSACAAPSQEAQPE 320

Query: 176 SSEAAPSSK 184
            S  AP ++
Sbjct: 321 CSPEAPPAE 329



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 52/161 (32%), Positives = 65/161 (40%), Gaps = 29/161 (18%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
           G   +  + G    ++ A   ++ A G      G P+E++PQ AA               
Sbjct: 199 GAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAA--------------- 243

Query: 62  AEGKAEEKEGEKDAAAAKEEAPKAEPEKTE--GAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
               A EK    D   A EE  K E +K E  GA+ A  E P A     A PG     EA
Sbjct: 244 ---VAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSA-----AGPGAPPEQEA 295

Query: 120 PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
             A E AAA A SA  A    PS+E       EAP A AA+
Sbjct: 296 APAEEPAAAAASSACAA----PSQEAQPECSPEAPPAEAAE 332


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 74.7 bits (182), Expect = 6e-14
 Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 40/258 (15%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKES----EPQAAAEPAEAKEGKEKPDQDAE 63
           KKK  + + E + E++++ +G   ++   P +       +AAA+ +E+   +E  D D E
Sbjct: 79  KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138

Query: 64  GKAEEKEGEK----DAAAAKEEAPKAEPEKTEGAAEAKAEPPK----------APEQEQA 109
              +++  +K     A AAK    KA+   ++  + ++ EPPK             Q +A
Sbjct: 139 EDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA 198

Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEE----GEPKKT--------EAPAAP 157
            P PA    APK A   AA + S++ ++      EE      PKKT        +AP   
Sbjct: 199 PPKPARA--APKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256

Query: 158 AAQETKSDGAPASDS--------KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP 209
           A   T+   +    S        KP  ++  P S   P +   P  +   Q P  + E+ 
Sbjct: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316

Query: 210 KPVEAPAANSDQTVTVKE 227
           +PVE+   +SD++ +  E
Sbjct: 317 QPVESSEDSSDESDSSSE 334



 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 58/218 (26%), Positives = 84/218 (38%), Gaps = 35/218 (16%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE--------EK 69
           +A  K    + A++    +   S   +  E A A   K  P +    KA          K
Sbjct: 204 RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK 263

Query: 70  EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
               + +++ EE  + +P K +    +   PP AP      P  + G + PK A     P
Sbjct: 264 SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP-----PKKSLGTQPPKKAVEKQQP 318

Query: 130 AESAAPAAGEEPSKEEGEPK----------KTEAPAAPAAQETKSDGAPASDSKPGSSEA 179
            ES+  ++ E  S  E E K           T+ P A  A E+ SD   +SDS     + 
Sbjct: 319 VESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSD---SSDSDSSEDDE 375

Query: 180 APSSKETPAATEAPSSTPKAQGPAASAEEP--KPVEAP 215
           APS    PA T   SS      PA + + P  KP  AP
Sbjct: 376 APSK---PAGTTKNSSNK----PAVTTKSPAVKPAAAP 406



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 56/203 (27%), Positives = 82/203 (40%), Gaps = 30/203 (14%)

Query: 48  PAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE-- 105
           P   K  K+    D+E  +EE+E  +   A K   P        G A AKA    + E  
Sbjct: 73  PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132

Query: 106 -----QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKK---------- 150
                +E     P   G  P+ A+AA AP + A  +  +  S  E EP K          
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQ-AKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVT 191

Query: 151 ----TEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK----AQ 200
               T+AP  P  AA +  +  A +S S   SS ++  S+E  AA     + PK    A+
Sbjct: 192 VKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK 251

Query: 201 GPAASAEEP--KPVEAPAANSDQ 221
            P  +A  P  K   +  ++SD+
Sbjct: 252 APVKAATTPTRKSSSSEDSSSDE 274



 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 60/225 (26%), Positives = 98/225 (43%), Gaps = 39/225 (17%)

Query: 11  GYNVNDEKAKEKDKKAEGAATEEEGTPK---ESEPQAAAEPA------EAKEGKEKPDQD 61
           G  +   KA     + E +++EEE T K    ++P+A A+ A      +A +G      D
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472

Query: 62  AEGKAEEKEGEKDAAAAKEEAPK-----AEPEKTEGAAEAKAEPPKAP-------EQEQA 109
           ++  + E+E EK + +A ++ P+     A P K   A + KAE   +        E+E+ 
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532

Query: 110 APGPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
             G  +   +APKA   +A  A++   A   + S+EE E KK  A     +   K     
Sbjct: 533 LKGKGSPRPQAPKANGTSALTAQNGKAA---KNSEEEEEEKKKAAVVVSKSGSLK----- 584

Query: 169 ASDSKPGSSEAAPSSKETPAA----TEAPSSTPKAQGPAASAEEP 209
               K   +EAA  + ETP A     + P++ PK +     A  P
Sbjct: 585 ----KRKQNEAAKEA-ETPQAKKIKLQTPNTFPKRKKGEKRASSP 624



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 56/248 (22%), Positives = 100/248 (40%), Gaps = 40/248 (16%)

Query: 17  EKAKEKDKKAEGA--ATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           +KA EK +  E +  +++E  +  E E +   +   +K   + P      ++     + D
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPG--PAAGGEAPKAAEAAAAPAES 132
           ++   +EAP      T+ ++   A   K+P  + AA    P  GG+     +A ++ +E 
Sbjct: 370 SSE-DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE 428

Query: 133 AAPAAGEEPSKEEGEPKKTEAPAA-----PAAQETKSDGAPASDSKPGSSE--------- 178
            + ++ EE +K+     K +A A      PA Q  +     +SDS   SSE         
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488

Query: 179 ------------AAPSSKETPAATEAPSSTPKAQGPAASAEE--------PKPVEAPAAN 218
                       AAPS   +    +A SS   +   ++  EE        P+P +AP AN
Sbjct: 489 AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP-QAPKAN 547

Query: 219 SDQTVTVK 226
               +T +
Sbjct: 548 GTSALTAQ 555



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 21/169 (12%)

Query: 65  KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
           K  E++ + +   AK+   KA    +E ++E          +E+   GP A   A  A  
Sbjct: 62  KVPERKLQANGPVAKKAKKKASSSDSEDSSE----------EEEEVQGPPAKKAAVPAKR 111

Query: 125 AAAAPAESAAPA----AGEEPSKEEGEPKKTEAPAAPAAQ-ETKSDGAPASDSKPGSSEA 179
               P ++AA A    + EE S ++ E  + + P     + + K+  AP   +K   S++
Sbjct: 112 VGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDS 171

Query: 180 APSSKETPAATEAPSSTP---KAQ---GPAASAEEPKPVEAPAANSDQT 222
             SS++ P   + P  TP   KAQ    P  +   PK     AA+S  +
Sbjct: 172 DSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSS 220



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 53/247 (21%), Positives = 102/247 (41%), Gaps = 43/247 (17%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQ-AAAEPAEAKEGKEKPDQDAEGKAE 67
           KK    + + +     + + A ++  GT K S  + A    + A +    P Q   G  +
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK 415

Query: 68  EKEGEKDAAAAKEEAPKAEPEKT-------------------------EGAAEAKAEPPK 102
               + D+++++EE+  +E EKT                         +G+ ++ ++   
Sbjct: 416 LLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDS 475

Query: 103 APEQEQ----------AAPGPAAGGEAP-KAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
           +  +E+            P   AGG AP K A A    AES+  ++ ++ S+EE E  K 
Sbjct: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE--KL 533

Query: 152 EAPAAPAAQETKSDGAPASDSKPG----SSEAAPSSKETPAATEAPSSTPKAQGPAASAE 207
           +   +P  Q  K++G  A  ++ G    +SE     K+  A   + S + K +    +A+
Sbjct: 534 KGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAK 593

Query: 208 EPKPVEA 214
           E +  +A
Sbjct: 594 EAETPQA 600



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 46/218 (21%), Positives = 76/218 (34%), Gaps = 32/218 (14%)

Query: 37  PKES----EPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
           PK+S     P+ A E  +  E  E    +++  +EE++     A   +   K  P K   
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA 359

Query: 93  AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG-------------- 138
            + + +    + E ++A   PA   +      A    + +  PAA               
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR 419

Query: 139 ---------EEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-----APSSK 184
                    E  S EE + KK  A   P A    +   PA  +  GS ++     + SS+
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
           E    T   +   K Q  A  A   KP  A    ++ +
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517



 Score = 34.7 bits (78), Expect = 0.069
 Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 16/111 (14%)

Query: 6   SKKKKGYNVN----DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA-EAKEGKEKPDQ 60
           +KK K  + N    D+ ++E+++K +G     +G+P+   P+A    A  A+ GK     
Sbjct: 509 AKKGKAESSNSSSSDDSSEEEEEKLKG-----KGSPRPQAPKANGTSALTAQNGK----- 558

Query: 61  DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP 111
            A   +EE+E EK  AA       +  ++ +  A  +AE P+A + +   P
Sbjct: 559 -AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 215 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 272

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 330

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 331 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 389 VQVGKQEEDSRSSSEESDSDREALAA 414



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 57/206 (27%), Positives = 80/206 (38%), Gaps = 21/206 (10%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D    +
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDVE 213

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
            +A +   +    +A AK  P K      A P P      P  A A A+  ++  P    
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKG-----ATPAP------PGKAGAVASQTKAGKPEEDS 262

Query: 140 EPSKEEGEPKKTEAPAAPAAQETKSDG---------APASDSKPGSSEAAPSSKETPAAT 190
           E S EE    + E PAA A  + K+ G         APA +S    +  AP  K  PA  
Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
           +A +   +    ++S E     EAPA
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPA 348



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 669 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 721

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 722 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 781

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
            G S AA + K+  + + +  S    + PAA  SA+  KP
Sbjct: 842 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 880



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 301

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 302 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 351

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 352 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 399

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLGKSP 427



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 286 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 345

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 346 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 465 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 513



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 30/225 (13%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE-- 139
            P +  EK      AKAE  KA +   + P PA G        +  +P +SA P+A    
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATGKTVANLL-SGKSPRKSAEPSANTTL 169

Query: 140 -EPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----------------AAPS 182
              ++EEG      A A P         + + D+   S E                A+  
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP 229

Query: 183 SKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           +K TP     P+   KA   A+  +  KP E   ++S+++   +E
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 274



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 506 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 564

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 565 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 622

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 623 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 680

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 681 KQEDSESSEEESDSEEAAASPAQVKTSVKK 710



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 318 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 376

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 377 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 494

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 555 AKPALKIPQTKA 566



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 599 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 656

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 657 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 716

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 717 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 775 KAVATAA 781



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 42/174 (24%), Positives = 65/174 (37%), Gaps = 18/174 (10%)

Query: 58   PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
            P     G +  KE  + +   K+E P  +  K        T+ A +  A+     +   A
Sbjct: 956  PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1015

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
               P++G ++      A +P  ++  A G    ++   PK  E   A  A E+  D   +
Sbjct: 1016 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRK---PKLPEVQQATKAPESSDDSEDS 1072

Query: 170  SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
            SDS  GS E      E P   +   S     GP  S  E    E  A +S+  V
Sbjct: 1073 SDSSSGSEE----DGEGP---QGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1119



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 618 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 738 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 795

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 796 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 829



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 46/187 (24%), Positives = 71/187 (37%), Gaps = 21/187 (11%)

Query: 27   EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
            +   T +   PK  E Q A +  E+ +  E     + G  E+ EG + A +A        
Sbjct: 1041 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPT- 1099

Query: 87   PEKTEGAAEAKAEPPKAPEQEQAAPGPA--AGGEAPKAAEAAAAPAESAAPAAGEEPSKE 144
            P +TE   E  A   ++ E +  AP  +  +G   P        PA S A  A       
Sbjct: 1100 PSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTP-----GLTPANSQASKA------- 1145

Query: 145  EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP-KAQGPA 203
               PK   +P+  +    K D     ++KP    A   S +T     A  +TP K++ P 
Sbjct: 1146 --TPKLDSSPSVSSTLAAKDDPDGKQEAKP-QQAAGMLSPKTGGKEAASGTTPQKSRKPK 1202

Query: 204  ASAEEPK 210
              A  P+
Sbjct: 1203 KGAGNPQ 1209



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 16/47 (34%), Positives = 27/47 (57%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
            K  KKK      D++ KEK KKA+ A+T++  +P + + +   + AE
Sbjct: 1363 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1409



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 41/186 (22%), Positives = 71/186 (38%), Gaps = 10/186 (5%)

Query: 23   DKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
            + +A  A  + + +P  S   AA +  + K+  E   Q A G    K G K+AA+     
Sbjct: 1139 NSQASKATPKLDSSPSVSSTLAAKDDPDGKQ--EAKPQQAAGMLSPKTGGKEAASGTTPQ 1196

Query: 83   PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE------SAAPA 136
               +P+K  G  +A     ++   +     P    EA   A       E           
Sbjct: 1197 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1256

Query: 137  AGEEPSKEEGEPKKTEAPA-APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
              +E S++  E +K +     PAA+  +S       +  G  EA+ S ++T   ++  + 
Sbjct: 1257 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG-GEASVSPEKTSTTSKGKAK 1315

Query: 196  TPKAQG 201
              KA G
Sbjct: 1316 RDKASG 1321



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)

Query: 50   EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
            E+++ K   DQ A      K+ +K  A    EA    PEKT   ++ KA+  KA    + 
Sbjct: 1267 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1325

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
              G  + G      E      +      G + S     KE+ +  K +       ++ K+
Sbjct: 1326 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1385

Query: 165  DGAPASDSKPGSSEAAPSSKETPAAT 190
              A   DS+  S +     K+T   T
Sbjct: 1386 KKASTKDSESPSQKKKKKKKKTAEQT 1411



 Score = 31.2 bits (69), Expect = 0.76
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
            GK  + K   +V ++K K     ++GA  E EE   K        + +  K  KEK   D
Sbjct: 1312 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1370

Query: 62   AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
               K +EK+ +      K++A KA  + +E  ++ K +  K   ++
Sbjct: 1371 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1410


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)

Query: 19  AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
           +  +D  +    T+ EG P     Q  A     KE   +    A GK      + +G   
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
             A + + P+ E E +E  +E++ E P       KA E   Q +AA  PA G        
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317

Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
             P  A A A+  ++  P    E S EE    + E PAA A  + K+ G         AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
           A +S    +  AP  K  PA  +A +   +    ++S E     EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D     
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
           E  P  +P + + ++ +  E P      +AAP P   G+  P+    A  PA+ A     
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268

Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
           E  S EEG   + EAPA                   APA                   A 
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328

Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
           +TK+ G P  DS+  S E++ S +ETPAA    +A +S   +Q  AASA   E P+   A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 215 PA 216
           PA
Sbjct: 388 PA 389



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
            G S AA + K+  + + +  S    + PAA  SA+  KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 45/191 (23%), Positives = 76/191 (39%), Gaps = 26/191 (13%)

Query: 58   PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEA--------------KAEPPKA 103
            P     G +  KE  + +   K+E P  + +   G   A              K   PK 
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092

Query: 104  PEQEQAAPGPAAGGEAPKAAEAAAAP---------AESAAPAAGEEPSKEEGEPKKTEAP 154
            PE +QA   P +  ++  ++++++           A+SA    G  PS+ E   ++T A 
Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1152

Query: 155  AAPAAQETKSDGAPASDSKPGSSEA-APSSKETPAATEAP--SSTPKAQGPAASAEEPKP 211
            ++       S    +    PG + A + +SK TP    +P  SST  A+      +E KP
Sbjct: 1153 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1212

Query: 212  VEAPAANSDQT 222
             +A    S +T
Sbjct: 1213 QQAAGMLSPKT 1223



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 632 AKPALKIPQTKA 643



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 852 KAVATAA 858



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
           ++  ++ E++++AE  A   + TP+ +   ++   A+     KEK   + E   +     
Sbjct: 82  ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139

Query: 73  KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
              A  K  A     +    +AE  A      E E+    PA G  A P    A  A + 
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
           S   ++  + +  EG+P    A    ++  TK   A  +   PG   +  P  K      
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
              +  P+ +  ++        EAPA    Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
            P +  EK      AKAE  KA +   + P PA G       +  A      +P    EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163

Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
           S         +EEG      A A P       A  +  D + +SD          KP   
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
           +A+  S+KE+PA   AP+       TP+ +G    PA  A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267



 Score = 41.2 bits (95), Expect = 7e-04
 Identities = 46/211 (21%), Positives = 80/211 (37%), Gaps = 12/211 (5%)

Query: 11   GYNVNDEKAKEKD-KKAEGAATEEE---GTPKESEPQAAAEPAEAKEGKEKP---DQDAE 63
            G + + E ++  D KK EG AT+ +   GT   + PQ+ +  A+      KP   +    
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098

Query: 64   GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
             KA E   + + ++      + + E  +GA  A       P + +      A   +    
Sbjct: 1099 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1158

Query: 124  EAAAAPAESAAPAAGEEPSKEEGE---PKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
             A +    S     G  P+  +     PK   +P+  +    K D     ++KP    A 
Sbjct: 1159 VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP-QQAAG 1217

Query: 181  PSSKETPAATEAPSSTP-KAQGPAASAEEPK 210
              S +T     A  +TP K++ P   A  P+
Sbjct: 1218 MLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 60/277 (21%), Positives = 89/277 (32%), Gaps = 73/277 (26%)

Query: 10   KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
            K + +    A  K+   +GAA           P     P+ A+ GK+  D  +  +  + 
Sbjct: 892  KTHQIRAALAPAKESPRKGAAPT---------PPGKTGPSAAQAGKQD-DSGSSSEESDS 941

Query: 70   EGEKDAAAAKEEAPK------------AEPEKTEGAAEAKAEPPKAPEQEQAA------- 110
            +GE  AA    +  K            A P  T   A+A + P KA   E  A       
Sbjct: 942  DGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSES 1001

Query: 111  -------------PGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA-- 155
                         PG          A    AP  S A A+  + S    + KK E PA  
Sbjct: 1002 EDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061

Query: 156  -----------APAAQETKSDG-----------------AP-ASDSKPGSSEAAPSSKET 186
                       +P +   ++ G                 AP +SD    SS+++  S+E 
Sbjct: 1062 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1121

Query: 187  PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
                +   S     GP  S  E    E  A +S+  V
Sbjct: 1122 GEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1158



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 16/47 (34%), Positives = 27/47 (57%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
            K  KKK      D++ KEK KKA+ A+T++  +P + + +   + AE
Sbjct: 1402 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1448



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 41/186 (22%), Positives = 71/186 (38%), Gaps = 10/186 (5%)

Query: 23   DKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
            + +A  A  + + +P  S   AA +  + K+  E   Q A G    K G K+AA+     
Sbjct: 1178 NSQASKATPKLDSSPSVSSTLAAKDDPDGKQ--EAKPQQAAGMLSPKTGGKEAASGTTPQ 1235

Query: 83   PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE------SAAPA 136
               +P+K  G  +A     ++   +     P    EA   A       E           
Sbjct: 1236 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1295

Query: 137  AGEEPSKEEGEPKKTEAPA-APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
              +E S++  E +K +     PAA+  +S       +  G  EA+ S ++T   ++  + 
Sbjct: 1296 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG-GEASVSPEKTSTTSKGKAK 1354

Query: 196  TPKAQG 201
              KA G
Sbjct: 1355 RDKASG 1360



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)

Query: 50   EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
            E+++ K   DQ A      K+ +K  A    EA    PEKT   ++ KA+  KA    + 
Sbjct: 1306 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1364

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
              G  + G      E      +      G + S     KE+ +  K +       ++ K+
Sbjct: 1365 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1424

Query: 165  DGAPASDSKPGSSEAAPSSKETPAAT 190
              A   DS+  S +     K+T   T
Sbjct: 1425 KKASTKDSESPSQKKKKKKKKTAEQT 1450



 Score = 31.2 bits (69), Expect = 0.76
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
            GK  + K   +V ++K K     ++GA  E EE   K        + +  K  KEK   D
Sbjct: 1351 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1409

Query: 62   AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
               K +EK+ +      K++A KA  + +E  ++ K +  K   ++
Sbjct: 1410 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)

Query: 19  AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
           +  +D  +    T+ EG P     Q  A     KE   +    A GK      + +G   
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
             A + + P+ E E +E  +E++ E P       KA E   Q +AA  PA G        
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317

Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
             P  A A A+  ++  P    E S EE    + E PAA A  + K+ G         AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
           A +S    +  AP  K  PA  +A +   +    ++S E     EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D     
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
           E  P  +P + + ++ +  E P      +AAP P   G+  P+    A  PA+ A     
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268

Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
           E  S EEG   + EAPA                   APA                   A 
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328

Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
           +TK+ G P  DS+  S E++ S +ETPAA    +A +S   +Q  AASA   E P+   A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 215 PA 216
           PA
Sbjct: 388 PA 389



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
            G S AA + K+  + + +  S    + PAA  SA+  KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 632 AKPALKIPQTKA 643



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 852 KAVATAA 858



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
           ++  ++ E++++AE  A   + TP+ +   ++   A+     KEK   + E   +     
Sbjct: 82  ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139

Query: 73  KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
              A  K  A     +    +AE  A      E E+    PA G  A P    A  A + 
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
           S   ++  + +  EG+P    A    ++  TK   A  +   PG   +  P  K      
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
              +  P+ +  ++        EAPA    Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 33/167 (19%), Positives = 60/167 (35%), Gaps = 8/167 (4%)

Query: 58   PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
            P     G +  KE  + +   K+E P  +  K        T+ A +  A+     +   A
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1092

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
               P++G ++      A +P  ++  A G    ++   P+  +A  AP + +   D + +
Sbjct: 1093 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1152

Query: 170  SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
            S       E    +K        PS T       A+      V AP+
Sbjct: 1153 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1199



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 12/169 (7%)

Query: 27   EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKE---GEKDAAAAKEEAP 83
            +   T +   PK  E Q A +  E+ +  E     + G  E+ E   G K A        
Sbjct: 1118 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS 1177

Query: 84   KAEPEKTEGAAEAKAEPPKAPEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAA 137
            + E    E AAE+  +   AP Q        PG   A  +A KA  +  ++P+ S+  AA
Sbjct: 1178 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1237

Query: 138  GEEP-SKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSS 183
             ++P  K+E +P++     +P    +E  S   P    KP      P +
Sbjct: 1238 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1286



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
            P +  EK      AKAE  KA +   + P PA G       +  A      +P    EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163

Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
           S         +EEG      A A P       A  +  D + +SD          KP   
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
           +A+  S+KE+PA   AP+       TP+ +G    PA  A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 16/47 (34%), Positives = 27/47 (57%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
            K  KKK      D++ KEK KKA+ A+T++  +P + + +   + AE
Sbjct: 1439 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1485



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)

Query: 50   EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
            E+++ K   DQ A      K+ +K  A    EA    PEKT   ++ KA+  KA    + 
Sbjct: 1343 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1401

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
              G  + G      E      +      G + S     KE+ +  K +       ++ K+
Sbjct: 1402 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1461

Query: 165  DGAPASDSKPGSSEAAPSSKETPAAT 190
              A   DS+  S +     K+T   T
Sbjct: 1462 KKASTKDSESPSQKKKKKKKKTAEQT 1487



 Score = 31.2 bits (69), Expect = 0.76
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
            GK  + K   +V ++K K     ++GA  E EE   K        + +  K  KEK   D
Sbjct: 1388 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1446

Query: 62   AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
               K +EK+ +      K++A KA  + +E  ++ K +  K   ++
Sbjct: 1447 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1486


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 215 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 272

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 330

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 331 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 389 VQVGKQEEDSRSSSEESDSDREALAA 414



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 57/206 (27%), Positives = 80/206 (38%), Gaps = 21/206 (10%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D    +
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDVE 213

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
            +A +   +    +A AK  P K      A P P      P  A A A+  ++  P    
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKG-----ATPAP------PGKAGAVASQTKAGKPEEDS 262

Query: 140 EPSKEEGEPKKTEAPAAPAAQETKSDG---------APASDSKPGSSEAAPSSKETPAAT 190
           E S EE    + E PAA A  + K+ G         APA +S    +  AP  K  PA  
Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
           +A +   +    ++S E     EAPA
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPA 348



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 669 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 721

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 722 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 781

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
            G S AA + K+  + + +  S    + PAA  SA+  KP
Sbjct: 842 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 880



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 301

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 302 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 351

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 352 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 399

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLGKSP 427



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 286 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 345

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 346 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 465 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 513



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 30/225 (13%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE-- 139
            P +  EK      AKAE  KA +   + P PA G        +  +P +SA P+A    
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATGKTVANLL-SGKSPRKSAEPSANTTL 169

Query: 140 -EPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----------------AAPS 182
              ++EEG      A A P         + + D+   S E                A+  
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP 229

Query: 183 SKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           +K TP     P+   KA   A+  +  KP E   ++S+++   +E
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 274



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 506 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 564

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 565 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 622

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 623 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 680

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 681 KQEDSESSEEESDSEEAAASPAQVKTSVKK 710



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 318 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 376

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 377 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 494

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 555 AKPALKIPQTKA 566



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 599 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 656

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 657 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 716

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 717 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 775 KAVATAA 781



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 33/167 (19%), Positives = 60/167 (35%), Gaps = 8/167 (4%)

Query: 58   PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
            P     G +  KE  + +   K+E P  +  K        T+ A +  A+     +   A
Sbjct: 956  PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1015

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
               P++G ++      A +P  ++  A G    ++   P+  +A  AP + +   D + +
Sbjct: 1016 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1075

Query: 170  SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
            S       E    +K        PS T       A+      V AP+
Sbjct: 1076 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1122



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 12/169 (7%)

Query: 27   EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKE---GEKDAAAAKEEAP 83
            +   T +   PK  E Q A +  E+ +  E     + G  E+ E   G K A        
Sbjct: 1041 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS 1100

Query: 84   KAEPEKTEGAAEAKAEPPKAPEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAA 137
            + E    E AAE+  +   AP Q        PG   A  +A KA  +  ++P+ S+  AA
Sbjct: 1101 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1160

Query: 138  GEEP-SKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSS 183
             ++P  K+E +P++     +P    +E  S   P    KP      P +
Sbjct: 1161 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1209



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 618 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 738 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 795

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 796 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 829



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 16/47 (34%), Positives = 27/47 (57%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
            K  KKK      D++ KEK KKA+ A+T++  +P + + +   + AE
Sbjct: 1362 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1408



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)

Query: 50   EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
            E+++ K   DQ A      K+ +K  A    EA    PEKT   ++ KA+  KA    + 
Sbjct: 1266 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1324

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
              G  + G      E      +      G + S     KE+ +  K +       ++ K+
Sbjct: 1325 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1384

Query: 165  DGAPASDSKPGSSEAAPSSKETPAAT 190
              A   DS+  S +     K+T   T
Sbjct: 1385 KKASTKDSESPSQKKKKKKKKTAEQT 1410



 Score = 31.2 bits (69), Expect = 0.76
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
            GK  + K   +V ++K K     ++GA  E EE   K        + +  K  KEK   D
Sbjct: 1311 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1369

Query: 62   AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
               K +EK+ +      K++A KA  + +E  ++ K +  K   ++
Sbjct: 1370 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1409


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)

Query: 19  AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
           +  +D  +    T+ EG P     Q  A     KE   +    A GK      + +G   
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
             A + + P+ E E +E  +E++ E P       KA E   Q +AA  PA G        
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317

Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
             P  A A A+  ++  P    E S EE    + E PAA A  + K+ G         AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
           A +S    +  AP  K  PA  +A +   +    ++S E     EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D     
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
           E  P  +P + + ++ +  E P      +AAP P   G+  P+    A  PA+ A     
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268

Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
           E  S EEG   + EAPA                   APA                   A 
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328

Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
           +TK+ G P  DS+  S E++ S +ETPAA    +A +S   +Q  AASA   E P+   A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 215 PA 216
           PA
Sbjct: 388 PA 389



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
            G S AA + K+  + + +  S    + PAA  SA+  KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 632 AKPALKIPQTKA 643



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 852 KAVATAA 858



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 52/210 (24%), Positives = 85/210 (40%), Gaps = 37/210 (17%)

Query: 11   GYNVNDEKAKEKD-KKAEGAATEEE---GTPKESEPQA---------------------A 45
            G + + E ++  D KK EG AT+ +   GT   + PQ+                     A
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098

Query: 46   AEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EGAAEAKAEPPK 102
             +  E+ +  E     + G  E+ EG + A +A    P     +T   E AAE+  +   
Sbjct: 1099 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVV 1158

Query: 103  APEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAAGEEP-SKEEGEPKKTEAPA 155
            AP Q        PG   A  +A KA  +  ++P+ S+  AA ++P  K+E +P++     
Sbjct: 1159 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1218

Query: 156  AP--AAQETKSDGAPASDSKPGSSEAAPSS 183
            +P    +E  S   P    KP      P +
Sbjct: 1219 SPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1248



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
           ++  ++ E++++AE  A   + TP+ +   ++   A+     KEK   + E   +     
Sbjct: 82  ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139

Query: 73  KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
              A  K  A     +    +AE  A      E E+    PA G  A P    A  A + 
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
           S   ++  + +  EG+P    A    ++  TK   A  +   PG   +  P  K      
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
              +  P+ +  ++        EAPA    Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
            P +  EK      AKAE  KA +   + P PA G       +  A      +P    EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163

Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
           S         +EEG      A A P       A  +  D + +SD          KP   
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
           +A+  S+KE+PA   AP+       TP+ +G    PA  A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 39/198 (19%), Positives = 67/198 (33%), Gaps = 18/198 (9%)

Query: 37   PKESEPQAAAEPAEAKEG----KEKPDQDAEGKAEEKEGEKDAAAAKE-----------E 81
            P  S    AA PA+A+      K +  +     +  +  ++D   A +            
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 82   APKAEPEKTEGAAEAKAEPPKAPEQ---EQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG 138
             P A P     A+ A A   K   +    +   GPA   ++      A +P  ++  A G
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG 1083

Query: 139  EEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK 198
                ++   P+  +A  AP + +   D + +S       E    +K        PS T  
Sbjct: 1084 TNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTET 1143

Query: 199  AQGPAASAEEPKPVEAPA 216
                 A+      V AP+
Sbjct: 1144 LVEETAAESSEDDVVAPS 1161



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 16/47 (34%), Positives = 27/47 (57%)

Query: 4    KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
            K  KKK      D++ KEK KKA+ A+T++  +P + + +   + AE
Sbjct: 1401 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1447



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)

Query: 50   EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
            E+++ K   DQ A      K+ +K  A    EA    PEKT   ++ KA+  KA    + 
Sbjct: 1305 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1363

Query: 110  APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
              G  + G      E      +      G + S     KE+ +  K +       ++ K+
Sbjct: 1364 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1423

Query: 165  DGAPASDSKPGSSEAAPSSKETPAAT 190
              A   DS+  S +     K+T   T
Sbjct: 1424 KKASTKDSESPSQKKKKKKKKTAEQT 1449



 Score = 31.2 bits (69), Expect = 0.76
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
            GK  + K   +V ++K K     ++GA  E EE   K        + +  K  KEK   D
Sbjct: 1350 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1408

Query: 62   AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
               K +EK+ +      K++A KA  + +E  ++ K +  K   ++
Sbjct: 1409 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1448


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)

Query: 18  KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
           KA EK  +   A+   +GTP K + P    +A A  ++ K GK  P++D+E  +EE  + 
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E++  AAK         KT     A A P K   ++ AAP P  G   P  A+A A   E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             + ++ EE   EE  P   +A  +  A + ++  APA +S    +  AP  K  PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
                 +    ++S E     EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)

Query: 19  AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
           +  +D  +    T+ EG P     Q  A     KE   +    A GK      + +G   
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
             A + + P+ E E +E  +E++ E P       KA E   Q +AA  PA G        
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317

Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
             P  A A A+  ++  P    E S EE    + E PAA A  + K+ G         AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
           A +S    +  AP  K  PA  +A +   +    ++S E     EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425



 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K   K AE +A     +  E E    A  A AK G     Q A+  +E+     D     
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
           E  P  +P + + ++ +  E P      +AAP P   G+  P+    A  PA+ A     
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268

Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
           E  S EEG   + EAPA                   APA                   A 
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328

Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
           +TK+ G P  DS+  S E++ S +ETPAA    +A +S   +Q  AASA   E P+   A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 215 PA 216
           PA
Sbjct: 388 PA 389



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 57/220 (25%), Positives = 89/220 (40%), Gaps = 30/220 (13%)

Query: 9   KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
           K G  V   KA   +K+ +  ++EEE   +E    AAA PA+ K   +K    A   A  
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
               K   +A  +   A  +  + +      P + P+     A GPA+    G     AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858

Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +A   P E +  +  E  S+EE          G+  +  A  APA +  +   AP    K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918

Query: 174 PGSS--------EAAPSSKETPAATEAPSSTPKAQGPAAS 205
            G S        ++  SS+E+ +  EAP++   AQ   +S
Sbjct: 919 TGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)

Query: 2   GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
           G   S+ K G    D ++        E++  A  A  + + + K S+  AA+ PA     
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
           KE P    +G A    G+   A AK +A K E +    + E+ +E       E+A     
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428

Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
             G+AP+   AA+APA+  +P  G  P+     P+KT  PAA   Q  K +     DS+ 
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
            SSE + S +E  AA  A    P  + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           KA  K  +   A+   + +P++     P     PA AK    K ++D++  +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
           A A  + + KA P+    +A AK  P K A        GPAA                 E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
           +    EA AA   +     G+ P  +                 P     PA P+AQ  K 
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541

Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
           +     DS+  S E++ SS  E P A       P  +    +  + KP  +PA    Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
           +P +  PQ A  P   +   EKP  ++E   E  +    ++A AA   A           
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641

Query: 84  KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
           KA P+KT   A AK  P     +AP +   A  PA  G +P  A     PAE ++ +   
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699

Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
           +  +E+     T  +A +     + K+   P   S    +      K  P  T+  +   
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757

Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
           K +   +S EE    EA A+ +    +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)

Query: 2   GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
           G  ++K + G    D ++  ++  +E  A  +   P    PQ  A  A AKE   K    
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453

Query: 58  -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
                             ++D+   +EE + +++A AA   A        P+ +P  T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 93  AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
                K   P  P +   A   A  G+  + +E+++   ES+  + GE P+       K 
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571

Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
            G   + K T +PA        P A + K++    +      S  +  S+E PAA  A  
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 195 STPKAQGPAASA 206
           + P  + P   A
Sbjct: 632 AKPALKIPQTKA 643



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)

Query: 44  AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
           A + PA A  G ++P +D+   +EE + E++         +A+        +A + P K 
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733

Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
              +  AP      GP     +A K  ++ ++  ES +  A   P++ +   KKT+A A 
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
           PAA   ++  A  + S PG   + AA + + +P+  + P     +ST  A+GPA+     
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851

Query: 210 KPVEAPA 216
           K V   A
Sbjct: 852 KAVATAA 858



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
           ++  ++ E++++AE  A   + TP+ +   ++   A+     KEK   + E   +     
Sbjct: 82  ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139

Query: 73  KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
              A  K  A     +    +AE  A      E E+    PA G  A P    A  A + 
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
           S   ++  + +  EG+P    A    ++  TK   A  +   PG   +  P  K      
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
              +  P+ +  ++        EAPA    Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
           + +KAE  A  +    + S+P + +E +E +E  E        KA  +    +++    +
Sbjct: 61  RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
            P +  EK      AKAE  KA +   + P PA G       +  A      +P    EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163

Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
           S         +EEG      A A P       A  +  D + +SD          KP   
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
           +A+  S+KE+PA   AP+       TP+ +G    PA  A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)

Query: 15  NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
           + E++  +++K   A T  + +   K  + +AA+ P +   G+      P +      + 
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754

Query: 69  K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
           K E ++D+ +++EE+   E   +    +   +  +A     AA  P+A G   AP     
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
           AAA A+  +P+  + P +       T     PA+  +     A A+ ++ G  E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872

Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
           E   + E   +  + + P+    + +   APA  S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 73.6 bits (179), Expect = 1e-13
 Identities = 51/182 (28%), Positives = 78/182 (42%), Gaps = 8/182 (4%)

Query: 7   KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
           +KK+     +EK +E+  + EG   E EG  +E E     E  E +EGK E+ +++ EG+
Sbjct: 775 RKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGE 834

Query: 66  AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQ--EQAAPGPAAGGEAPKAA 123
            EE+EGE      +EE  + E E+ EG  E + E  +  E+  E    G    GE     
Sbjct: 835 GEEEEGE-----GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEE 889

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
           E      E      GEE  + EGE ++ E       +E + +G        G        
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949

Query: 184 KE 185
           +E
Sbjct: 950 EE 951



 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 54/209 (25%), Positives = 84/209 (40%), Gaps = 15/209 (7%)

Query: 10   KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK------EGK-EKPDQDA 62
            +G  V + K + ++++ EG   EEEG  +E E +   E  E K      EG+ E+  ++ 
Sbjct: 815  EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG 874

Query: 63   EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAG--GEA 119
            EG+ EE+EGE +     EE  + E E+ EG  E + E     E+E+    G   G  GE 
Sbjct: 875  EGEGEEEEGEGEG----EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG 930

Query: 120  PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA 179
                E      E       EE  + EGE ++ E       +    +G    + + G  E 
Sbjct: 931  EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990

Query: 180  APSSKETPAATEAPSSTPKAQGPAASAEE 208
                 E     E      + +G     EE
Sbjct: 991  EEEEGEEEGEEEG-EGEEEGEGEGEEEEE 1018



 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 52/194 (26%), Positives = 79/194 (40%), Gaps = 12/194 (6%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPD---QDAEGKAEEKEGE--KD 74
           KE++++ E    EE G  +E E     E  E KEG+ K +   ++ EG+ E++EGE  K+
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKE 778

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
             A KEE  K E E  +G  E +    +  E+E+   G   GGE  +  +      E   
Sbjct: 779 ERAGKEE--KGEEEGDQGEGEEEETEGRGEEKEEG--GEVEGGEV-EEGKGEREEEEEEG 833

Query: 135 PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
               EE   EE E +  E       +E   +G    + + G  E      E     E   
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG 893

Query: 195 STPKAQGPAASAEE 208
              + +G     EE
Sbjct: 894 EGEEEEGEGEGEEE 907



 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 46/186 (24%), Positives = 78/186 (41%), Gaps = 15/186 (8%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPK----------ESEPQAAAEPAEAK 52
            GK  ++++      E+ + + ++ EG   EEEG  K          E E +      E +
Sbjct: 822  GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881

Query: 53   EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPG 112
            EG+ + +++ EG+ EE+EGE +    +E   + E E+ EG  E + E  +   +E+   G
Sbjct: 882  EGEGEGEEEGEGEGEEEEGEGE--GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939

Query: 113  PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
                GE     E      E      GE   +EEGE +  E       +E + +G      
Sbjct: 940  EGEDGEGEGEEEEGEWEGEE---EEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996

Query: 173  KPGSSE 178
            + G  E
Sbjct: 997  EEGEEE 1002



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 46/193 (23%), Positives = 80/193 (41%), Gaps = 14/193 (7%)

Query: 7    KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE---PAEAKEGKEKPDQDAE 63
            ++++G    +E+ +E + + EG   E EG  +E E +   E     E +EG+ + +++ E
Sbjct: 850  EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909

Query: 64   GKAEEKEGE--------KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
            G+ EE+EGE        +     +EE  + E E  EG  E +    +  E+E    G   
Sbjct: 910  GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969

Query: 116  GGEAPKAAEAAAAPAESAAPA---AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
            G    +  E      E         GEE  +EEGE ++         +E + +G    + 
Sbjct: 970  GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029

Query: 173  KPGSSEAAPSSKE 185
              G  E     +E
Sbjct: 1030 GEGEGEEEEGEEE 1042



 Score = 58.9 bits (141), Expect = 3e-09
 Identities = 55/211 (26%), Positives = 84/211 (39%), Gaps = 8/211 (3%)

Query: 3    GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
            G+  ++ +G    +E   E +++ EG   EEEG  K  E     E    +E  E   +D 
Sbjct: 885  GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944

Query: 63   EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA 122
            EG+ EE+EGE +    +EE  + E E+ EG  E +    +  E+E    G    GE  + 
Sbjct: 945  EGEGEEEEGEWE---GEEEEGEGEGEE-EGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEG 999

Query: 123  AEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
             E      E       EE  + EGE +  E       +E + +G      K G  E    
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEG--EEREKEGEGEENRR 1057

Query: 183  SKETPAATEAP-SSTPKAQGPAASAEEPKPV 212
            ++E     E     T + +      EE K V
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEEYKKV 1088



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 50/200 (25%), Positives = 78/200 (39%), Gaps = 9/200 (4%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKE--GKEKPDQDAEGKAEEKEG-- 71
           +E+ KE + K EG   E EG  ++ E +   E    KE  G+E+ DQ  EG+ EE EG  
Sbjct: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ-GEGEEEETEGRG 805

Query: 72  -EKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128
            EK+     E  E  + + E+ E   E + E  +   +E+   G    GE     E    
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865

Query: 129 PAESAAPAAGEEPSKEEGEPK-KTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETP 187
             E        E  +EEGE + + E       +E + +G    + +    E     +E  
Sbjct: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925

Query: 188 AATEAPSSTPKAQGPAASAE 207
              E      + +G     E
Sbjct: 926 EEGEGEGEEEEGEGEGEDGE 945



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 52/204 (25%), Positives = 78/204 (38%), Gaps = 15/204 (7%)

Query: 18   KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
            + +E++ + EG   E EG  +E E +   E  E +  +E   +  EG+ E +E E +   
Sbjct: 931  EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990

Query: 78   AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
             +EE  +   E+ EG  E + E  +  E+E    G   G E     E      E      
Sbjct: 991  EEEEGEEEGEEEGEGEEEGEGEGEE--EEEGEVEGEVEGEEGEGEGE------EEEGEEE 1042

Query: 138  GEEPSKE-EGEP----KKTEAPAAPAAQETKSDGAPASDSKPGS--SEAAPSSKETPAAT 190
            GEE  KE EGE     ++ E       QET  +     D +     S+   S K     T
Sbjct: 1043 GEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKT 1102

Query: 191  EAPSSTPKAQGPAASAEEPKPVEA 214
                S    QG         PV++
Sbjct: 1103 YQKKSVTNTQGNGKEQRSKMPVQS 1126



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 51/215 (23%), Positives = 77/215 (35%), Gaps = 9/215 (4%)

Query: 15  NDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPD---QDAEGKAEEKE 70
           +DE+ +  ++K EGA   +    +E E +A  E  +   G KEK +    D   KAE  E
Sbjct: 580 SDEEVEIPEEK-EGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638

Query: 71  GEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG-EAPKAAEAAAAP 129
           G+  +    E+ P+   + T     + AE  +  E+E+       G  E P   E   A 
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698

Query: 130 AESAAPAAGEE---PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKET 186
            E      GEE     +E+G  K+         +E   +G      +    E     KE 
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEE 758

Query: 187 PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
               E      K +G     E     E      DQ
Sbjct: 759 GEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 47/220 (21%), Positives = 79/220 (35%), Gaps = 28/220 (12%)

Query: 16  DEKAKEKDKKAEGA---ATEEEGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKA 66
           D+   E ++  EG    A +EE   ++ E Q   E  +  + KE+        ++  G+ 
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ-KERNQEMEEGGEEEHGEG 738

Query: 67  EEKEGEKDAAAAKE-------EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
           EE+EG+++    KE       E  + E E+ +   E K E     E++    G    GE 
Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798

Query: 120 PKAAEAAAAPAESAAPAAGE--------EPSKEEGEPKKTEAPAAP---AAQETKSDGAP 168
            +         E      GE        E  +EEGE ++ E          +E + +G  
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             + + G  E      E     E      + +G     EE
Sbjct: 859 EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898



 Score = 41.2 bits (95), Expect = 7e-04
 Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 4/108 (3%)

Query: 7    KKKKGYNVNDEKAKEKDKKAEGAATEE-EGTPKESEPQAAAEPAEAKEGK---EKPDQDA 62
            ++++G    +E+  E++ + EG   EE EG  +E E        E +EG+   E+ + + 
Sbjct: 982  EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041

Query: 63   EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA 110
            EG+  EKEGE +      E  + E  K +   E + E     E ++ +
Sbjct: 1042 EGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVS 1089



 Score = 38.9 bits (89), Expect = 0.004
 Identities = 47/201 (23%), Positives = 74/201 (36%), Gaps = 22/201 (10%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE-EKEGE 72
           V++ KAK   +  +G     +GT +E    A     E +E  EK     +G+ E E+ GE
Sbjct: 636 VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKD----KGRGEMERPGE 691

Query: 73  KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
            +    KE A K E +K +G  + + E  +  ++E+       G E     E      E 
Sbjct: 692 GE----KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREE 747

Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
                GE   + EGE  + E          K +G    + + G  E     K      + 
Sbjct: 748 EEEKEGEGKEEGEGEEVEGE--------REKEEGERKKEERAGKEE-----KGEEEGDQG 794

Query: 193 PSSTPKAQGPAASAEEPKPVE 213
                + +G     EE   VE
Sbjct: 795 EGEEEETEGRGEEKEEGGEVE 815



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 35/166 (21%), Positives = 59/166 (35%), Gaps = 9/166 (5%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
           K+K ++  G  T++    +  +     E +E KEGK      ++G    +      A + 
Sbjct: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581

Query: 80  EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA-------AAAPAES 132
           EE     PE+ EGA ++K    +  E E         G   +  E         A  +E 
Sbjct: 582 EEV--EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG 639

Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
            A + GE     EG    T    +  A+  + +     +   G  E
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGE 685



 Score = 30.8 bits (68), Expect = 0.99
 Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 17   EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE-KDA 75
            E  +E++ + EG    EEG   E E +   E  E +E + + +++   + EE+E E K  
Sbjct: 1012 EGEEEEEGEVEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070

Query: 76   AAAKEEAPKAEPEKTEGAAEAK 97
               +EE  + + E+ +  ++ K
Sbjct: 1071 ETGEEENERQDGEEYKKVSKIK 1092


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 67.8 bits (164), Expect = 7e-12
 Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 23/234 (9%)

Query: 1   MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATE--------EEGTPKESEPQAAAEPAEAK 52
           +G +++ K +     DE A +    A G A            G PK    +   E  E  
Sbjct: 447 LGARVADKVRKRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHSENGVE--EDT 504

Query: 53  EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG---AAEAKAEPPKAPEQEQA 109
           EG+  P +   G   E  G   A  A +E P   P +T G   A  A  EP ++P +   
Sbjct: 505 EGRTGPKEGTPGSPSETPGPSPAGPAGDE-PAESPSETPGPRPAGPAGDEPAESPSE--- 560

Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
            PGP   G  P   E A +P+E+  P+    P+++E     +E P    A     + A +
Sbjct: 561 TPGPRPAG--PAGDEPAESPSETPGPSPAG-PTRDEPAESPSETPGPRPAGPAGDEPAES 617

Query: 170 SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
               PG   A P+  E PA  E+PS TP       + +EP      A   D  V
Sbjct: 618 PSETPGPRPAGPAGDE-PA--ESPSETPGPSPAGPTRDEPAKAGEAAELQDAEV 668



 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 53/189 (28%), Positives = 72/189 (38%), Gaps = 26/189 (13%)

Query: 15  NDEKAKEKDKKAEGAATEEEGTPKESEPQ--------AAAEPAEAKEGKEKP-------D 59
           + E   E+D   EG    +EGTP              A  EPAE+      P       D
Sbjct: 495 HSENGVEED--TEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGD 552

Query: 60  QDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
           + AE  +E   G + A  A +E P   P +T G + A     +  E     PGP   G  
Sbjct: 553 EPAESPSETP-GPRPAGPAGDE-PAESPSETPGPSPAGPTRDEPAESPSETPGPRPAG-- 608

Query: 120 PKAAEAAAAPAESAAP----AAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG 175
           P   E A +P+E+  P     AG+EP++   E     +PA P   E    G  A      
Sbjct: 609 PAGDEPAESPSETPGPRPAGPAGDEPAESPSE-TPGPSPAGPTRDEPAKAGEAAELQDAE 667

Query: 176 SSEAAPSSK 184
              +A S K
Sbjct: 668 VESSAKSGK 676


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.8 bits (164), Expect = 7e-12
 Identities = 60/227 (26%), Positives = 96/227 (42%), Gaps = 17/227 (7%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK-- 73
           ++K   ++K+ E  A EEE   K+S  +A A   + +EG+++ ++  E + EE EG K  
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546

Query: 74  ---DAAAAKE-EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
              +  + KE  + K E E+ EG  EA+AE  +A  +E+      +   A K    A A 
Sbjct: 547 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 606

Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE---- 185
            E    A    P     E  K+  P +P  ++ KS    +   + G S    S  E    
Sbjct: 607 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 666

Query: 186 -----TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
                +P   +A S  PK+  P   A+    V       ++   VKE
Sbjct: 667 SPVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKEEEEKEVKE 711



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 14/204 (6%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEEK 69
           + +E A    ++ + AA E+E  P+  E + AA+     A A E KE+  +  E + +E+
Sbjct: 476 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 535

Query: 70  EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPK----AAEA 125
           E E+D  A  ++A +   EK EG++E +    +  E E  A G  A  +  K     +E 
Sbjct: 536 EEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
            A   E  A A  E+P K      K+  P +P  ++ KS    +   + G S    S  E
Sbjct: 595 VATKEELVADAKVEKPEK-----AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 649

Query: 186 TPAATEAPSSTPKAQGPAASAEEP 209
               +  P S  + +G +  ++ P
Sbjct: 650 EKGKSPVPKSPVEEKGKSPVSKSP 673



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 60/212 (28%), Positives = 89/212 (41%), Gaps = 39/212 (18%)

Query: 24  KKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
           K+ EG   EEEG  +E E    A+  +A+EG  EK     + + E++EGE +A A  EEA
Sbjct: 521 KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA 580

Query: 83  PKAEPEKTEGAAE-------------------AKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
              E +K E  +E                   AK+  PK+P +E+        G++P   
Sbjct: 581 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK--------GKSPVPK 632

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
                  +S  P   + P +E+G   K+  P +P  ++ KS   P S S       +P  
Sbjct: 633 SPVEEKGKSPVP---KSPVEEKG---KSPVPKSPVEEKGKS---PVSKSPVEEKAKSPVP 683

Query: 184 KETPAATEAPSSTPKAQGPAASAEEPKPVEAP 215
           K      EA S     +G     EE +  EAP
Sbjct: 684 KS--PVEEAKSKAEVGKGEQKEEEEKEVKEAP 713



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 16/221 (7%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPK--------ESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
           DE AK  D+  EG + +E  + K        E+E +A  E AEAKE K K ++ +E  A 
Sbjct: 540 DEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK-KVEEKSEEVAT 597

Query: 68  EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAGGEAPKAAEAA 126
           ++E   DA   K E  K+   K+    + K+  PK+P +E+  +P P +  E    +   
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 657

Query: 127 AAPAESAAPA-AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
            +P E    +   + P +E+ +    ++P   A  + +       + +    + AP  ++
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 717

Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
                E P   P+ +     AE P   EA A     T +VK
Sbjct: 718 VEKKEEKPKDVPEKK----KAESPVKEEAVAEVVTITKSVK 754



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 27/167 (16%)

Query: 63  EGKAEEKEGEKDAA--AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
           E K E+++ E + A  A  EE   +  E+ + AAE K E P+A E+E A           
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA----------- 507

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
               A  +P ++ AP   EE  ++E E  + E       +E + +GA +  ++ G SE  
Sbjct: 508 ----AKKSPVKATAPEVKEEEGEKEEEEGQEE-------EEEEDEGAKSDQAEEGGSEKE 556

Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
            SS++     E   +  +A+G  A A+E K VE     S++  T +E
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE---EKSEEVATKEE 600



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 33/241 (13%)

Query: 3   GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE--PAEAKEGKE---- 56
           G+  ++++      ++A+E   + EG++ +EEG  +E E +A AE   AEAKE K+    
Sbjct: 532 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 591

Query: 57  ------KPDQDAEGKAEEKEGEKDAAAAK---------------EEAPKAEPEKTEGAAE 95
                 K +  A+ K E+ E  K                     EE  K+   K+    +
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 651

Query: 96  AKAEPPKAPEQEQA-APGPAAGGEAPKAAEAAAAPAESAAPAA--GEEPSKEEGEPKKTE 152
            K+  PK+P +E+  +P   +  E    +    +P E A   A  G+   KEE E +  E
Sbjct: 652 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 711

Query: 153 APAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPV 212
           AP     ++ +       + K   S   P  +E  A     + + K      + EE KP+
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAES---PVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 768

Query: 213 E 213
           +
Sbjct: 769 Q 769



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 58/216 (26%), Positives = 88/216 (40%), Gaps = 18/216 (8%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE---AKEGKEKPDQD 61
           +S K +   V   K K + K  E    E +   ++SE + A        A   KE+  + 
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 491

Query: 62  AEGKAEEKEGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
           AE K EE E E++  AAK+   KA  PE  E   E + E  +  E+E+         E  
Sbjct: 492 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE--------DEGA 543

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE-- 178
           K+ +A    +E    +  EE  +EEGE   TEA A     E K +      S+  +++  
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGE---TEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600

Query: 179 -AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
             A +  E P   ++P      +    S     PVE
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 636



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 50/187 (26%), Positives = 75/187 (40%), Gaps = 34/187 (18%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK--------PDQDAEGKAE 67
           +EK K    K+      +   PK    +    P      +EK        P ++A+ KAE
Sbjct: 636 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 695

Query: 68  EKEGEKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGGEAPKAAE 124
             +GE+     KE  EAPK E        E K E PK  PE+++A        E+P   E
Sbjct: 696 VGKGEQKEEEEKEVKEAPKEEK------VEKKEEKPKDVPEKKKA--------ESPVKEE 741

Query: 125 AAA--APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
           A A       +     E+ +KEEG+P + E       +E +  G      + GS + A  
Sbjct: 742 AVAEVVTITKSVKVHLEKETKEEGKPLQQE-------KEKEKAGGEGGSEEEGSDKGAKG 794

Query: 183 SKETPAA 189
           S++   A
Sbjct: 795 SRKEDIA 801



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 55/249 (22%), Positives = 88/249 (35%), Gaps = 34/249 (13%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
           ++KG +   +   E+  K+  + +  E   K   P++  E A++K    K +Q  E + E
Sbjct: 649 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 708

Query: 68  EKEGEKDAAAAK-EEAPKAEPEKTEGAAEAKAEP------------------------PK 102
            KE  K+    K EE PK  PEK +  +  K E                         P 
Sbjct: 709 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 768

Query: 103 APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQE- 161
             E+E+   G   G E   + + A    +      GE   KEE E +  E  +    ++ 
Sbjct: 769 QQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 828

Query: 162 ---TKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAAN 218
                 D +PA + K G       S+E    T+         G  A+    K V      
Sbjct: 829 VVTNGLDLSPADEKKGGD-----KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 883

Query: 219 SDQTVTVKE 227
            +   T +E
Sbjct: 884 EEHEETFEE 892



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA--EAKEGKEKPDQDA 62
           L K+ K      ++ KEK+K      +EEEG+ K ++     + A     EGKE+ +Q+ 
Sbjct: 757 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 816

Query: 63  EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
           + K   +E EK       +   A+ +K    +E K    K  E+  +  G  A
Sbjct: 817 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGA 869



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 16/107 (14%)

Query: 7   KKKKGYNVNDEKAKEKDKKAEGAA----------------TEEEGTPKESEPQAAAEPAE 50
           K++K  +V ++K  E   K E  A                T+EEG P + E +      E
Sbjct: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780

Query: 51  AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAK 97
               +E  D+ A+G  +E          KEE  +   EK  G  E K
Sbjct: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.8 bits (164), Expect = 7e-12
 Identities = 60/227 (26%), Positives = 96/227 (42%), Gaps = 17/227 (7%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK-- 73
           ++K   ++K+ E  A EEE   K+S  +A A   + +EG+++ ++  E + EE EG K  
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170

Query: 74  ---DAAAAKE-EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
              +  + KE  + K E E+ EG  EA+AE  +A  +E+      +   A K    A A 
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230

Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE---- 185
            E    A    P     E  K+  P +P  ++ KS    +   + G S    S  E    
Sbjct: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290

Query: 186 -----TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
                +P   +A S  PK+  P   A+    V       ++   VKE
Sbjct: 291 SPVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKEEEEKEVKE 335



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 14/204 (6%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEEK 69
           + +E A    ++ + AA E+E  P+  E + AA+     A A E KE+  +  E + +E+
Sbjct: 100 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 159

Query: 70  EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPK----AAEA 125
           E E+D  A  ++A +   EK EG++E +    +  E E  A G  A  +  K     +E 
Sbjct: 160 EEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
            A   E  A A  E+P K      K+  P +P  ++ KS    +   + G S    S  E
Sbjct: 219 VATKEELVADAKVEKPEK-----AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 273

Query: 186 TPAATEAPSSTPKAQGPAASAEEP 209
               +  P S  + +G +  ++ P
Sbjct: 274 EKGKSPVPKSPVEEKGKSPVSKSP 297



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 60/212 (28%), Positives = 89/212 (41%), Gaps = 39/212 (18%)

Query: 24  KKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
           K+ EG   EEEG  +E E    A+  +A+EG  EK     + + E++EGE +A A  EEA
Sbjct: 145 KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA 204

Query: 83  PKAEPEKTEGAAE-------------------AKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
              E +K E  +E                   AK+  PK+P +E+        G++P   
Sbjct: 205 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK--------GKSPVPK 256

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
                  +S  P   + P +E+G   K+  P +P  ++ KS   P S S       +P  
Sbjct: 257 SPVEEKGKSPVP---KSPVEEKG---KSPVPKSPVEEKGKS---PVSKSPVEEKAKSPVP 307

Query: 184 KETPAATEAPSSTPKAQGPAASAEEPKPVEAP 215
           K      EA S     +G     EE +  EAP
Sbjct: 308 KS--PVEEAKSKAEVGKGEQKEEEEKEVKEAP 337



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 16/221 (7%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPK--------ESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
           DE AK  D+  EG + +E  + K        E+E +A  E AEAKE K K ++ +E  A 
Sbjct: 164 DEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK-KVEEKSEEVAT 221

Query: 68  EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAGGEAPKAAEAA 126
           ++E   DA   K E  K+   K+    + K+  PK+P +E+  +P P +  E    +   
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281

Query: 127 AAPAESAAPA-AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
            +P E    +   + P +E+ +    ++P   A  + +       + +    + AP  ++
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341

Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
                E P   P+ +     AE P   EA A     T +VK
Sbjct: 342 VEKKEEKPKDVPEKK----KAESPVKEEAVAEVVTITKSVK 378



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 27/167 (16%)

Query: 63  EGKAEEKEGEKDAA--AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
           E K E+++ E + A  A  EE   +  E+ + AAE K E P+A E+E A           
Sbjct: 83  ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA----------- 131

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
               A  +P ++ AP   EE  ++E E  + E       +E + +GA +  ++ G SE  
Sbjct: 132 ----AKKSPVKATAPEVKEEEGEKEEEEGQEE-------EEEEDEGAKSDQAEEGGSEKE 180

Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
            SS++     E   +  +A+G  A A+E K VE     S++  T +E
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE---EKSEEVATKEE 224



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 33/241 (13%)

Query: 3   GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE--PAEAKEGKE---- 56
           G+  ++++      ++A+E   + EG++ +EEG  +E E +A AE   AEAKE K+    
Sbjct: 156 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215

Query: 57  ------KPDQDAEGKAEEKEGEKDAAAAK---------------EEAPKAEPEKTEGAAE 95
                 K +  A+ K E+ E  K                     EE  K+   K+    +
Sbjct: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275

Query: 96  AKAEPPKAPEQEQA-APGPAAGGEAPKAAEAAAAPAESAAPAA--GEEPSKEEGEPKKTE 152
            K+  PK+P +E+  +P   +  E    +    +P E A   A  G+   KEE E +  E
Sbjct: 276 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 335

Query: 153 APAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPV 212
           AP     ++ +       + K   S   P  +E  A     + + K      + EE KP+
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAES---PVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 392

Query: 213 E 213
           +
Sbjct: 393 Q 393



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 58/216 (26%), Positives = 88/216 (40%), Gaps = 18/216 (8%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE---AKEGKEKPDQD 61
           +S K +   V   K K + K  E    E +   ++SE + A        A   KE+  + 
Sbjct: 56  ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115

Query: 62  AEGKAEEKEGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
           AE K EE E E++  AAK+   KA  PE  E   E + E  +  E+E+         E  
Sbjct: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE--------DEGA 167

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE-- 178
           K+ +A    +E    +  EE  +EEGE   TEA A     E K +      S+  +++  
Sbjct: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGE---TEAEAEGEEAEAKEEKKVEEKSEEVATKEE 224

Query: 179 -AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
             A +  E P   ++P      +    S     PVE
Sbjct: 225 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 260



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 50/187 (26%), Positives = 75/187 (40%), Gaps = 34/187 (18%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK--------PDQDAEGKAE 67
           +EK K    K+      +   PK    +    P      +EK        P ++A+ KAE
Sbjct: 260 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 319

Query: 68  EKEGEKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGGEAPKAAE 124
             +GE+     KE  EAPK E        E K E PK  PE+++A        E+P   E
Sbjct: 320 VGKGEQKEEEEKEVKEAPKEEK------VEKKEEKPKDVPEKKKA--------ESPVKEE 365

Query: 125 AAA--APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
           A A       +     E+ +KEEG+P + E       +E +  G      + GS + A  
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQE-------KEKEKAGGEGGSEEEGSDKGAKG 418

Query: 183 SKETPAA 189
           S++   A
Sbjct: 419 SRKEDIA 425



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 55/249 (22%), Positives = 88/249 (35%), Gaps = 34/249 (13%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
           ++KG +   +   E+  K+  + +  E   K   P++  E A++K    K +Q  E + E
Sbjct: 273 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 332

Query: 68  EKEGEKDAAAAK-EEAPKAEPEKTEGAAEAKAEP------------------------PK 102
            KE  K+    K EE PK  PEK +  +  K E                         P 
Sbjct: 333 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 392

Query: 103 APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQE- 161
             E+E+   G   G E   + + A    +      GE   KEE E +  E  +    ++ 
Sbjct: 393 QQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 452

Query: 162 ---TKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAAN 218
                 D +PA + K G       S+E    T+         G  A+    K V      
Sbjct: 453 VVTNGLDLSPADEKKGGD-----KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 507

Query: 219 SDQTVTVKE 227
            +   T +E
Sbjct: 508 EEHEETFEE 516



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA--EAKEGKEKPDQDA 62
           L K+ K      ++ KEK+K      +EEEG+ K ++     + A     EGKE+ +Q+ 
Sbjct: 381 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 440

Query: 63  EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
           + K   +E EK       +   A+ +K    +E K    K  E+  +  G  A
Sbjct: 441 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGA 493



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 16/107 (14%)

Query: 7   KKKKGYNVNDEKAKEKDKKAEGAA----------------TEEEGTPKESEPQAAAEPAE 50
           K++K  +V ++K  E   K E  A                T+EEG P + E +      E
Sbjct: 345 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404

Query: 51  AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAK 97
               +E  D+ A+G  +E          KEE  +   EK  G  E K
Sbjct: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 60/221 (27%), Positives = 87/221 (39%), Gaps = 16/221 (7%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
           +  A+ K KKA  AA+EE   P   E +   E +     +E+  ++AE         +  
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEM-EASGVSGNEEEMVEEAEATVNNSSDTESI 734

Query: 76  AAAKEEAPK------AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
            +   EA K       +P  T GA      PP  P ++  AP      E   A+EA  AP
Sbjct: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPT-----EPTPASEATGAP 789

Query: 130 AESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDS---KPGSSEAAPSSKE 185
               AP +   P      E K+ E  AAP  +E +    PA++      G +E    S+ 
Sbjct: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSEC 849

Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
           T  A E P+    A+   A+AE     E     S +  T K
Sbjct: 850 TEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 890



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 61/223 (27%), Positives = 93/223 (41%), Gaps = 31/223 (13%)

Query: 20   KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKP------DQDAEGKAEEKEGEK 73
            +EK+++   A   EEG  +E +P AA E A      E+P      ++  EG A+ K+ E 
Sbjct: 808  EEKEEETAAAPPVEEG--EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEA 865

Query: 74   DAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP-------GPAAGGEAPK-AAEA 125
             A A  E A KAE ++        A+   AP+   ++          A GG+  +  +  
Sbjct: 866  -AEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR 924

Query: 126  AAAPAESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSK 184
             +    +  P A   P K  + +  K  A A P  Q TK    P  D+ P  ++ AP + 
Sbjct: 925  PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP--TKPAPPAP 982

Query: 185  ETPA-------ATEAPSSTPKAQ----GPAASAEEPKPVEAPA 216
              P        A + P S+P+ +     P A  E  KPV  PA
Sbjct: 983  PPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025



 Score = 36.2 bits (82), Expect = 0.024
 Identities = 28/141 (19%), Positives = 62/141 (43%), Gaps = 10/141 (7%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
           L+KK + Y    +    +  +  G + +++   ++ + Q   +P      +EK +++ E 
Sbjct: 472 LTKKNENY----KSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK 527

Query: 65  KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA-- 122
           +AE++E + +    KE+  K + + T G    + E   +  ++ A       G   ++  
Sbjct: 528 EAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMA 587

Query: 123 ----AEAAAAPAESAAPAAGE 139
               +E A  P +SA  A+ E
Sbjct: 588 NEANSEEAITPQQSAELASME 608



 Score = 28.5 bits (62), Expect = 4.9
 Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 4/104 (3%)

Query: 33   EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
            E+  P +  P A   P   +   + P Q       +       A  + E P   P     
Sbjct: 970  EDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFP---AF 1026

Query: 93   AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP-AESAAP 135
            AAEA+  P   P      P P    E  KA+  A  P A S AP
Sbjct: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAP 1070


>gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]
          Length = 274

 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)

Query: 7   KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
           KK KG   +D +A E +   +  A   +G  K+ E    AE A A   K ++P +  E  
Sbjct: 85  KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144

Query: 66  AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
           +EEK+GE DAA   A  +AP +  EK   A    A          +    A   E PK A
Sbjct: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 204

Query: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
           +  AA   +AA  PAA +  +K   +P      ++ A +  ++      ++KP  S    
Sbjct: 205 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 260

Query: 182 SSKE 185
             KE
Sbjct: 261 EGKE 264



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
           K   DQ  E    + E +   AA K +A         K + EK +    A+AE  K  E 
Sbjct: 49  KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108

Query: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158
              A G    GE    AEAA  PA  + P     AGE PS+E   EG+    + AP APA
Sbjct: 109 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165

Query: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
           + E K+  A    +   S++ +PSSK             + PAA T A ++TP A+  AA
Sbjct: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225

Query: 205 SAEEPKPVE 213
            A    P E
Sbjct: 226 KATAQPPTE 234


>gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]
          Length = 238

 Score = 66.2 bits (160), Expect = 2e-11
 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)

Query: 7   KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
           KK KG   +D +A E +   +  A   +G  K+ E    AE A A   K ++P +  E  
Sbjct: 49  KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108

Query: 66  AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
           +EEK+GE DAA   A  +AP +  EK   A    A          +    A   E PK A
Sbjct: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 168

Query: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
           +  AA   +AA  PAA +  +K   +P      ++ A +  ++      ++KP  S    
Sbjct: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 224

Query: 182 SSKE 185
             KE
Sbjct: 225 EGKE 228



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)

Query: 55  KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
           K   DQ  E    + E +   AA K +A         K + EK +    A+AE  K  E 
Sbjct: 13  KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72

Query: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158
              A G    GE    AEAA  PA  + P     AGE PS+E   EG+    + AP APA
Sbjct: 73  P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129

Query: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
           + E K+  A    +   S++ +PSSK             + PAA T A ++TP A+  AA
Sbjct: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189

Query: 205 SAEEPKPVE 213
            A    P E
Sbjct: 190 KATAQPPTE 198


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 21/226 (9%)

Query: 10   KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
            KG  V    A+  +  + G   E+E   +E E     E AE +E +E  D D     +E 
Sbjct: 1015 KGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDES 1074

Query: 70   EGEKDAAAAKEEAPK----AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
            E + +  A  E + K    ++ E+T     +KAE   + E  +++   ++   +P ++E 
Sbjct: 1075 ENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSE- 1133

Query: 126  AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSD--------GAPASDSKPGSS 177
                 E    A  EE  +EE E    E+ A+   ++ + D        GAPA DS  G  
Sbjct: 1134 ----DEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSL-GME 1188

Query: 178  EAAPSSKETPAATEAPS---STPKAQGPAASAEEPKPVEAPAANSD 220
            E      E  A  E PS     P   G    A+  +P E P  + +
Sbjct: 1189 EEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQE 1234



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 57/223 (25%), Positives = 79/223 (35%), Gaps = 25/223 (11%)

Query: 15   NDEKAKEKDKKAEGAATEEEGTPK-----ESEPQAAAEPAEAKEGKEKPDQDAEGKA--- 66
            + E     +     +  EEE   +     E E +  AE + A  G E  +QD E  A   
Sbjct: 1118 SSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP 1177

Query: 67   ----------EEKEGEKDAAAAKEEAPKA--EPEKTEGAAEA--KAEPPKAPEQEQAAPG 112
                      EE+   +  A A EE P    EP    G  E     EPP+ P   Q   G
Sbjct: 1178 GAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQ--EG 1235

Query: 113  PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
                   P A E  A P  S   A   +   E   P     P  P     +    P+   
Sbjct: 1236 AMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPP 1295

Query: 173  KPGSSEAA-PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214
            +P +++A+ PS    P A + P  TP   G  A ++  + V A
Sbjct: 1296 EPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPA 1338



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 24/221 (10%)

Query: 6    SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGK 65
            S+K +G +  +E       KAE  ++ E     E E  + + P+ +++     +++   +
Sbjct: 1087 SEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSED-----EEEVVAR 1141

Query: 66   AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
             EE+E E++   A+E    A PE  E   E  A  P AP  +      + G E     E 
Sbjct: 1142 EEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVD------SLGMEEEVDIET 1195

Query: 126  AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA-------PASDSK---PG 175
             A   E   P+  +EP    G  +  ++   P       +GA       PA + +   P 
Sbjct: 1196 EAVAPEER-PSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPL 1254

Query: 176  SSEAAPSSKETPAATEAPSSTP-KAQGPAASAEEPKPVEAP 215
            S E AP   +     E P   P   Q P      P+P   P
Sbjct: 1255 SPERAP-EHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 49/243 (20%), Positives = 83/243 (34%), Gaps = 35/243 (14%)

Query: 5    LSKKKKGYNVNDEKAKEKDK----------KAEGAATEEEGTP--------------KES 40
            L+  K G + ++++ K KD+          K EG   E  G                K  
Sbjct: 908  LTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRK 967

Query: 41   EPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP 100
            EP       + K  +     D E +  E+E ++D A    E  K +P K  G     A P
Sbjct: 968  EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDP-KGVGVRRRPARP 1026

Query: 101  PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
             +     +     +   E     E   A  E       ++ S +  E +  +   A +  
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEA 1086

Query: 161  ETKSDG----------APASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
              K +G            +      SSE++ SS+   ++  +PSS+   +   A  EE +
Sbjct: 1087 SEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEE 1146

Query: 211  PVE 213
              E
Sbjct: 1147 EEE 1149



 Score = 30.4 bits (67), Expect = 1.3
 Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 11/96 (11%)

Query: 100 PPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAA 159
           PP       AA G    GE  +A   A  P   A P A E+P    G       P  P  
Sbjct: 409 PPPEEPTATAAFGARDSGEFRRAP--APPPLPPAEPLAKEKPGTPPG-------PPPPDT 459

Query: 160 QETKSDGAPAS--DSKPGSSEAAPSSKETPAATEAP 193
              +  G P      +P  S   P+ + +PA  E P
Sbjct: 460 NSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKP 495



 Score = 30.0 bits (66), Expect = 1.7
 Identities = 39/189 (20%), Positives = 61/189 (32%), Gaps = 42/189 (22%)

Query: 20   KEKDKKAEGAATEEEGTPKESEPQAAA--EPAEAKEGKEKPDQDAEG------KAEEKEG 71
            +E D + E  A EE  +  +  P      EPA+++E  E+P    EG      +   KE 
Sbjct: 1189 EEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEV 1248

Query: 72   EKDAAAAKEEAPK---------------------------------AEPEKTEGAAEAKA 98
            E     + E AP+                                  EPE T+ +  +  
Sbjct: 1249 EARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVP 1308

Query: 99   EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP-AAP 157
              P A +     PG        ++ E   A      P +G         P+   +P + P
Sbjct: 1309 PEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYP 1368

Query: 158  AAQETKSDG 166
            A   + S G
Sbjct: 1369 APSPSLSSG 1377


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 63/199 (31%), Positives = 82/199 (41%), Gaps = 26/199 (13%)

Query: 36   TPKESEPQAAAEPAEAK----EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP-----KAE 86
            +PK +   +A  P   K      KE P          KEG   A  A ++AP      + 
Sbjct: 860  SPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP--ATPAPKQAPALSMTSSS 917

Query: 87   PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
            P+K   A  A    P +P  + A   PAA   +PK   A  +P  +  P A   PS + G
Sbjct: 918  PKKAR-ATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGG 976

Query: 147  E--PKKTEAPAAPAAQETKSDGAPASDSKPGS----SEAAPSSKETPAATEAP--SSTPK 198
               P    AP  PAA      G PA+ S  G+    +   PS K +PAAT  P  +STP 
Sbjct: 977  PATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPP 1036

Query: 199  AQGPAASAEEPKPVEAPAA 217
            A  P      P P  +PAA
Sbjct: 1037 AATP------PSPKGSPAA 1049



 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 64/224 (28%), Positives = 86/224 (38%), Gaps = 25/224 (11%)

Query: 14   VNDEKAKEKDKKAEGAATEEEG--TPKESEP---QAAAEPAEAKEGKEKPDQ--DAEGKA 66
            ++ +KA       EGAAT  +G  TP    P   + A   +  K G   P    D    A
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA 1469

Query: 67   EEKEGEKDAAAAKEEAPKAEPEKTE------GAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
                  K+  A K+ A  + P+K        GA    A  P +P++  A P       AP
Sbjct: 1470 VTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAP 1529

Query: 121  ------KAAEAAAAPAESAAPAAGEEPS--KEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
                  K   A  AP E+  P A   PS  K    P   EAPA P+++E  S  A     
Sbjct: 1530 TATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVT--- 1586

Query: 173  KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
             P + + APS KE        S +PK      +   P P + PA
Sbjct: 1587 -PSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPA 1629



 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 59/191 (30%), Positives = 75/191 (39%), Gaps = 21/191 (10%)

Query: 37   PKESEPQAAAEPAEAKEGKEKP-DQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT--EGA 93
            PKE+   +       KEG   P  + A   +      K A A    APK  P     +GA
Sbjct: 882  PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP--APKGIPASPSPKGA 939

Query: 94   AEAKAEPPKAPEQEQAAPG-------PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
                A  P +P+   A P        PAA   +PK   A  +P  +  P A   PS + G
Sbjct: 940  PTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGG 999

Query: 147  --EPKKTEAPAAPAAQETKSDGAPASDSKP-GSS----EAAPSSKETPAATEAPSSTPKA 199
               P    AP  PA       G+PA+   P G+S       PS K +PAAT  P   P  
Sbjct: 1000 PATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTT 1059

Query: 200  QGPAASAEEPK 210
              PAA+   PK
Sbjct: 1060 --PAATLPSPK 1068



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 54/200 (27%), Positives = 73/200 (36%), Gaps = 22/200 (11%)

Query: 36   TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPK---AEPEKTEG 92
            +PK +    AA P   K G   P           +G     AA   +PK   A P     
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGPATPPPKGA 1263

Query: 93   AAEAKAEPPK-----APEQEQAAPGPAA-GGEAPKAAEAAAAPAESAAPAAGEEPSKE-- 144
                 A PP      A    + AP PA     +PK   A + P  +  P A   PS +  
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323

Query: 145  EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ-GPA 203
             G P    AP  PA       G P   +   SS+  P++  +      P++TP  + GPA
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPA 1383

Query: 204  ASAEEPKPVEA-PAANSDQT 222
             +   PK   A P+   D T
Sbjct: 1384 MTPPSPKRGPAIPSPKGDPT 1403



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 47/182 (25%), Positives = 62/182 (34%), Gaps = 9/182 (4%)

Query: 36   TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
            +PK +    AA P   K G   P                       +PK  P        
Sbjct: 935  SPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPP 994

Query: 96   AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTE--- 152
            +    P  P  + A   PA    +PK + AA    + A+      P   +G P  T    
Sbjct: 995  SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054

Query: 153  -APAAPAAQETKSDGAPASDSKPGS---SEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             AP  PAA      G PA+ S  G+     A P S +   AT +P   P    PAA+   
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP--MPPAATPPS 1112

Query: 209  PK 210
            PK
Sbjct: 1113 PK 1114



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 56/215 (26%), Positives = 79/215 (36%), Gaps = 29/215 (13%)

Query: 27   EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
            EG AT     PK++ P  +   +  K+ +  P       +   +G     AA   +PK  
Sbjct: 898  EGPATP---APKQA-PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGG 953

Query: 87   PE--KTEGAAEAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAA 137
            P     + A    A  P +P+   A P P       AA   +PK   A  +P  +  P A
Sbjct: 954  PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPA 1013

Query: 138  GEEPSKEEGEPKKTEAPAA----PAAQETKSDGAPASDSKPGSSEAAP-----SSKETPA 188
               PS + G P  T  P      PAA      G+PA+   P  +   P     S K  PA
Sbjct: 1014 VTPPSPK-GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPA 1072

Query: 189  ------ATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
                  A   P++TP +     +   PK    P A
Sbjct: 1073 TPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPA 1107



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 57/193 (29%), Positives = 73/193 (37%), Gaps = 31/193 (16%)

Query: 36   TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPE--KTEGA 93
            +PK +    AA P   K G   P           +G     AA   +PK  P     +GA
Sbjct: 958  SPKWAPTPPAATPPSPKGGPATPSP---------KGAPTPPAATPPSPKGGPATPSPKGA 1008

Query: 94   AEAKAEPPKAPEQEQAAPG--------PAAGGEAPKAAEAAAAPAESAAPA--AGEEPSK 143
                A  P +P+   AA          PAA   +PK +  AA P    AP   A   PS 
Sbjct: 1009 PTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGS-PAATPLPKGAPTTPAATLPSP 1067

Query: 144  EEG--EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG 201
            + G   P    AP  PAA      G PA+ S  G   A      TP + +   +TP  +G
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG---APMPPAATPPSPKGGLATPPHKG 1124

Query: 202  ----PAASAEEPK 210
                PAA+   PK
Sbjct: 1125 APTTPAATPPSPK 1137



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 56/203 (27%), Positives = 69/203 (33%), Gaps = 21/203 (10%)

Query: 27   EGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEE-KEGEKDAAAAKEE 81
            +GA T    TP   +   AA P    A        P       A    +G     AA   
Sbjct: 1006 KGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLP 1065

Query: 82   APKAEPE--KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA-----AAPAESAA 134
            +PK  P     +GA    A  P +P+   A P P      P A   +     A P    A
Sbjct: 1066 SPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGA 1125

Query: 135  PA--AGEEPSKEEG--EPKKTEAPAAPAAQETKSDG---APASDSKPGSSEAAPSSKETP 187
            P   A   PS + G   P    AP  PAA      G    P     P +  A P S +  
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1185

Query: 188  AATEAPSSTPKAQGPAASAEEPK 210
             AT +P   P    PAA+   PK
Sbjct: 1186 LATPSPKGAPTT--PAATPPSPK 1206



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 51/197 (25%), Positives = 71/197 (36%), Gaps = 27/197 (13%)

Query: 36   TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGA 93
            +PK +    AA P   K G   P           +G     AA   +PK        +GA
Sbjct: 1190 SPKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGLATPSPKGA 1240

Query: 94   AEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA-----AAPAESAAP-AAGEEPSKEEGE 147
                A  P +P+   A P P      P A   +     A P    AP  A   P   +G 
Sbjct: 1241 PTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGG 1300

Query: 148  PKKTE---APAAPAAQETKSDGAPASDSKPGS----SEAAPSSKETPAATEAPSSTPKAQ 200
            P  +    AP  PAA      G+P +    G+    +   PS K TP     P++TP ++
Sbjct: 1301 PATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT---LPATTPSSK 1357

Query: 201  GPAASAEEPKPVEAPAA 217
            G   +    +    PAA
Sbjct: 1358 GGPTTPSSKEGPTPPAA 1374



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 53/206 (25%), Positives = 72/206 (34%), Gaps = 32/206 (15%)

Query: 37   PKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGAA 94
            PK +    AA P   K G   P           +G     AA   +PK        +GA 
Sbjct: 1168 PKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGLATPSPKGAP 1218

Query: 95   EAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG- 146
               A  P +P+   A P P       AA   +PK   A   P  +  P A   PS + G 
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGL 1278

Query: 147  -EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG---- 201
              P    AP           G PA+ S P  +   P++  TP + +    TP  +G    
Sbjct: 1279 ATPPHKGAPNPAVVTPPSPKGGPAT-SPPKGAPTPPAA--TPPSPKGSPGTPPPKGAPTP 1335

Query: 202  PAASAEEPK-----PVEAPAANSDQT 222
            PA +   PK     P   P++    T
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPT 1361



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 40/164 (24%), Positives = 53/164 (32%), Gaps = 12/164 (7%)

Query: 37   PKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT--EGAA 94
            PK +    AA P   K G   P           +G  + A     +PK  P  +  +GA 
Sbjct: 1260 PKGAPTPPAATPPSLKGGLATPPH---------KGAPNPAVVTPPSPKGGPATSPPKGAP 1310

Query: 95   EAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
               A  P +P+     P P  G   P A    +       PA           P   E P
Sbjct: 1311 TPPAATPPSPKGSPGTP-PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGP 1369

Query: 155  AAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK 198
              PAA  +   G   +   P    A PS K  P +      +PK
Sbjct: 1370 TPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 41/147 (27%), Positives = 57/147 (38%), Gaps = 16/147 (10%)

Query: 87   PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
            P+KT      K E P  P  ++A+  PA     P   + A +P E   P A   PS +E 
Sbjct: 1558 PKKTPAIPTPK-EAPATPSSKEASSPPAV---TPSTYKGAPSPKELLIPPAVTSPSPKEA 1613

Query: 147  ---------EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
                      P+K  A  AP    T     P+S     +S A+ + K      +A    P
Sbjct: 1614 PTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLP 1673

Query: 198  KAQGPAASAEEPKPVEAPAANSDQTVT 224
              +GP A  E    + APA  S   +T
Sbjct: 1674 AKKGPTALKE---VLVAPAPESTPIIT 1697



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 53/191 (27%), Positives = 66/191 (34%), Gaps = 35/191 (18%)

Query: 36   TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGA 93
            +PK +    AA P   K G   P           +G     AA   +PK        +GA
Sbjct: 1098 SPKGAPMPPAATPPSPKGGLATPPH---------KGAPTTPAATPPSPKGGLATPPPKGA 1148

Query: 94   AEAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
                A  P +P+   A P P       AA   +PK   A  +P  +    A   PS + G
Sbjct: 1149 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1208

Query: 147  --EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAA 204
               P    AP  PAA          +   P    A PS K  P    A   +PK  GPA 
Sbjct: 1209 LATPSPKGAPTTPAA----------TPPSPKGGLATPSPKGAPTTPAATPPSPKG-GPAT 1257

Query: 205  SAEEPKPVEAP 215
                P P  AP
Sbjct: 1258 ----PPPKGAP 1264



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 51/189 (26%), Positives = 63/189 (33%), Gaps = 20/189 (10%)

Query: 34   EGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE--EAPKAEPEKTE 91
            +G+P    P+ A  P        K            +G     ++KE    P A P    
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG 1380

Query: 92   GAAEAKAEP---PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148
            G A     P   P  P  +     PA    +PK A A     E AA      PSK +  P
Sbjct: 1381 GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAAT-----PSKGDLTP 1435

Query: 149  KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK-AQGPAASAE 207
                    PA        APA+ S P    A PSSK  P        +PK    P   A 
Sbjct: 1436 --------PAVTPVSLKKAPAT-SAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVAT 1486

Query: 208  EPKPVEAPA 216
               P +APA
Sbjct: 1487 SSSPKKAPA 1495



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 46/167 (27%), Positives = 60/167 (35%), Gaps = 23/167 (13%)

Query: 70   EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEA 125
            +G KD+ A         P+   GA    A  P +P+      +  P P+     P   E 
Sbjct: 844  QGSKDSPATTHSPTPPSPK---GAPTPSAVTPLSPKGVTLPPKETPTPSVVN-LPFPKEG 899

Query: 126  AAAPAESAAPA---AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
             A PA   APA       P K    P     PA+P+ +   +  A A+   P    A PS
Sbjct: 900  PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA-ATPPSPKGGPATPS 958

Query: 183  SKETPAATEAPSSTPKAQGPAA----------SAEEPKPVEAPAANS 219
             K  P    A   +PK  GPA           +A  P P   PA  S
Sbjct: 959  PKWAPTPPAATPPSPKG-GPATPSPKGAPTPPAATPPSPKGGPATPS 1004



 Score = 38.9 bits (89), Expect = 0.004
 Identities = 49/182 (26%), Positives = 67/182 (36%), Gaps = 30/182 (16%)

Query: 42  PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPP 101
           PQ    P   K+G   PD    G         +A+   E +   +  K   A      PP
Sbjct: 803 PQTKRPPT--KKGSAGPDTPI-GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPP 859

Query: 102 KAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
                 + AP P+A    +PK       P E+  P+    P  +EG       PA PA +
Sbjct: 860 SP----KGAPTPSAVTPLSPKGV--TLPPKETPTPSVVNLPFPKEG-------PATPAPK 906

Query: 161 ETKSDGAPA---SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
           +     APA   + S P  + A P+ K  PA     S +PK      +A  P P   PA 
Sbjct: 907 Q-----APALSMTSSSPKKARATPAPKGIPA-----SPSPKGAPTPPAATPPSPKGGPAT 956

Query: 218 NS 219
            S
Sbjct: 957 PS 958



 Score = 38.1 bits (87), Expect = 0.006
 Identities = 45/207 (21%), Positives = 73/207 (35%), Gaps = 15/207 (7%)

Query: 24   KKAEGAATEEEGTPKESEPQAAAEPA---EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
            KK     T +E     S  +A++ PA      +G   P +     A      K+A     
Sbjct: 1559 KKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA 1618

Query: 81   EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE 140
              P + PEK       K  P   P        P++  ++P +  +      +  P A + 
Sbjct: 1619 VTPPS-PEKGPATPAPKGTPTSPPVT------PSSLKDSPTSPASVTCKMGATVPQASKG 1671

Query: 141  PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
               ++G     E   APA + T    AP         +   SS  +P     PS+   ++
Sbjct: 1672 LPAKKGPTALKEVLVAPAPESTPIITAPTRK----GPQTKKSSATSPPICPDPSAKNGSK 1727

Query: 201  GPAASAEEPKPVEAPAANSDQTVTVKE 227
            GP  S   P P+     +S +T   K+
Sbjct: 1728 GP-LSTVAPAPLLPVQKDSSKTAKGKD 1753



 Score = 35.0 bits (79), Expect = 0.053
 Identities = 27/121 (22%), Positives = 46/121 (38%), Gaps = 6/121 (4%)

Query: 90  TEGAAEAKAEPPKAPEQEQAAPGPAAG-GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148
           T   A   + P + P ++  A   A+  G     A++ +    S +P     P+K     
Sbjct: 757 TSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTK----- 811

Query: 149 KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
           K +  P  P    +       +   P +S +   SK++PA T +P+       P  SA  
Sbjct: 812 KGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVT 871

Query: 209 P 209
           P
Sbjct: 872 P 872



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 40/197 (20%), Positives = 67/197 (34%), Gaps = 24/197 (12%)

Query: 39  ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA 98
           +S P  +  PA    G +K D  +   A             E++  +    ++G     A
Sbjct: 732 KSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLA 791

Query: 99  EPP-----------KAPEQEQAAPGP---AAGGEAPKAAEAAAAPAESAAPAAGEEPSKE 144
           + P           K P  ++ + GP        +P +   A+   E++    G + S  
Sbjct: 792 DSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDS-- 849

Query: 145 EGEPKKTEAPAAPAAQETKSDGA-----PASDSKPGSSEAAPSSKETPAATEAPSSTPKA 199
              P  T +P  P+ +   +  A     P   + P      PS    P   E P++    
Sbjct: 850 ---PATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPK 906

Query: 200 QGPAASAEEPKPVEAPA 216
           Q PA S     P +A A
Sbjct: 907 QAPALSMTSSSPKKARA 923


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)

Query: 10  KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
           K  N         D   E + T  + T  E++         + +GKEK     E ++ EK
Sbjct: 122 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 181

Query: 70  EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
              KD A       +  PKAE      A     EP     +E A+     P P     AP
Sbjct: 182 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 241

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
              +  A     +AP   +EP+    +      P  PA   TK      + S P +  E 
Sbjct: 242 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 301

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
           AP++ + PA T   E   +TPK   P    E     + PA
Sbjct: 302 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 341



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 212 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 270

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P     AP    E A    +  AP   +EP+    +      P
Sbjct: 271 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 330

Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             PA      A  T  + AP +  KP     AP++ + PA T     TPK   P  + +E
Sbjct: 331 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 379

Query: 209 PKPV----EAPAANSDQTVTVKE 227
           P P      AP        T KE
Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTKE 402



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
           TPK+  P    EPA     KE      +  A     E      KE AP    K  P   E
Sbjct: 438 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496

Query: 92  GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
             A    E P     E+ AP            E A    ++AAP   +EP+    KE   
Sbjct: 497 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 556

Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
                     PK+T AP  P   A  T  + AP +  KP   E AP++ + P +T   + 
Sbjct: 557 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615

Query: 193 PSSTPKAQGPAASAEEPKP 211
             +TPK   P  + +EP P
Sbjct: 616 APTTPKGTAP-TTPKEPAP 633



 Score = 54.7 bits (130), Expect = 6e-08
 Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           E A    KK      +E    TPKE  P    EP+     +  P          KE    
Sbjct: 347 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 406

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
              +    PK EP  T     A   P +        P P    E         AP  +  
Sbjct: 407 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465

Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
           PA           PK+T AP  P      T    AP +  KP  +   E AP++ E P  
Sbjct: 466 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 524

Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
           T   E   +TPKA  P  + +EP P
Sbjct: 525 TTPEEPAPTTPKAAAP-NTPKEPAP 548



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
           TPKE  P    EPA     KE      +G A     E      K+ APK        EP 
Sbjct: 550 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608

Query: 89  KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
            T     A   P          P P    E         AP   +  AP   ++P+ +E 
Sbjct: 609 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 668

Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
            P  T+ P +  + +    T  + AP +  +P  +   + AP++ ETP  T +  STP  
Sbjct: 669 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 728

Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
                +  +      P  +++ T
Sbjct: 729 TKEPTTIHKSPDESTPELSAEPT 751



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 258 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 309

Query: 96  AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P    E AP   E A    +  AP A ++P+    +      P
Sbjct: 310 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 369

Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
             PA   TK + +P +  +P   ++++AP++ + PA T   S+  TPK   P  + +EP 
Sbjct: 370 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 427

Query: 211 P 211
           P
Sbjct: 428 P 428



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
           TPKE  P    EP      +  P          KE    A          EP  T   E 
Sbjct: 313 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 372

Query: 93  AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
           A     EP P  P++    P P     AP   +  A     +AP   +EPS    +    
Sbjct: 373 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
             P  PA       A  T  + AP +  +P    + + AP++ + PA T   E   +TPK
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 488

Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
              P         + E+P P      AP    + T T  E
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P    E      +G       KE AP            
Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 590

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
                PK P  ++ AP       +    + A    +  AP   +EP+       K  AP 
Sbjct: 591 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 642

Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
            P   A  T  + AP +  KP   E AP++ + P +T +     +TPK   P  + +EP 
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 701

Query: 211 PV--EAPAANSDQT 222
           P   + PA  + +T
Sbjct: 702 PTTPKKPAPTTPET 715



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
           E A    KK      +E    TPKE  P    +PA     +  P    E       K   
Sbjct: 433 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 492

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
              EK A    E+     PE  E A     EP P  PE+       AA    PK  E A 
Sbjct: 493 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 548

Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
              +  AP   +EP+     PK+T AP  P   A  T  + AP +  KP   E AP++ +
Sbjct: 549 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605

Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
            P +T                           E   +TPK   P  + +EP P   + PA
Sbjct: 606 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 664

Query: 217 ANSDQTVTVK 226
                  T K
Sbjct: 665 PKELAPTTTK 674



 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
           K+       E A    K+     T+E   T  +S P    EPA     K  P    E  A
Sbjct: 260 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 318

Query: 67  EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
                E      KE AP   EP  T     A   P K        P P    E       
Sbjct: 319 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
             +P     PA    P+  +  P  T+ PA     +A  T  + +P +  +P  +   E 
Sbjct: 379 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 434

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
           AP++ + PA T   E   +TPK   P  + ++P P
Sbjct: 435 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 468



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
           TPK + P    EPA     KE      +G A     E      K+ APK   P  T+G  
Sbjct: 619 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 677

Query: 95  EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
              ++ P     ++ AP     PA       A      P    +E + P   +EP     
Sbjct: 678 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 737

Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
           S +E  P+ +  P   A + + K  G P +      + AA   + T  A +  +      
Sbjct: 738 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 792

Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
            P  +   PK  +  A  +++T   K
Sbjct: 793 TPETTTAAPKMTKETATTTEKTTESK 818



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)

Query: 34  EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
           E TPK  E+ P+    P        KP+     K  +K  E+D     E    APK   E
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 806

Query: 89  K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
                   TE    A      +   +   P      +    APK          +     
Sbjct: 807 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 866

Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
            EE +K +     ++A      + TK+   P S  KP +       K TP   +  S+ P
Sbjct: 867 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 926

Query: 198 KAQGPAASAE 207
           +    +  AE
Sbjct: 927 ELNPTSRIAE 936


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)

Query: 10  KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
           K  N         D   E + T  + T  E++         + +GKEK     E ++ EK
Sbjct: 163 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 222

Query: 70  EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
              KD A       +  PKAE      A     EP     +E A+     P P     AP
Sbjct: 223 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 282

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
              +  A     +AP   +EP+    +      P  PA   TK      + S P +  E 
Sbjct: 283 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 342

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
           AP++ + PA T   E   +TPK   P    E     + PA
Sbjct: 343 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 382



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 253 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 311

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P     AP    E A    +  AP   +EP+    +      P
Sbjct: 312 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 371

Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             PA      A  T  + AP +  KP     AP++ + PA T     TPK   P  + +E
Sbjct: 372 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 420

Query: 209 PKPV----EAPAANSDQTVTVKE 227
           P P      AP        T KE
Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTKE 443



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
           TPK+  P    EPA     KE      +  A     E      KE AP    K  P   E
Sbjct: 479 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537

Query: 92  GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
             A    E P     E+ AP            E A    ++AAP   +EP+    KE   
Sbjct: 538 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 597

Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
                     PK+T AP  P   A  T  + AP +  KP   E AP++ + P +T   + 
Sbjct: 598 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656

Query: 193 PSSTPKAQGPAASAEEPKP 211
             +TPK   P  + +EP P
Sbjct: 657 APTTPKGTAP-TTPKEPAP 674



 Score = 54.7 bits (130), Expect = 6e-08
 Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           E A    KK      +E    TPKE  P    EP+     +  P          KE    
Sbjct: 388 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 447

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
              +    PK EP  T     A   P +        P P    E         AP  +  
Sbjct: 448 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506

Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
           PA           PK+T AP  P      T    AP +  KP  +   E AP++ E P  
Sbjct: 507 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 565

Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
           T   E   +TPKA  P  + +EP P
Sbjct: 566 TTPEEPAPTTPKAAAP-NTPKEPAP 589



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
           TPKE  P    EPA     KE      +G A     E      K+ APK        EP 
Sbjct: 591 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649

Query: 89  KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
            T     A   P          P P    E         AP   +  AP   ++P+ +E 
Sbjct: 650 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 709

Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
            P  T+ P +  + +    T  + AP +  +P  +   + AP++ ETP  T +  STP  
Sbjct: 710 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 769

Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
                +  +      P  +++ T
Sbjct: 770 TKEPTTIHKSPDESTPELSAEPT 792



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 299 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 350

Query: 96  AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P    E AP   E A    +  AP A ++P+    +      P
Sbjct: 351 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 410

Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
             PA   TK + +P +  +P   ++++AP++ + PA T   S+  TPK   P  + +EP 
Sbjct: 411 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 468

Query: 211 P 211
           P
Sbjct: 469 P 469



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
           TPKE  P    EP      +  P          KE    A          EP  T   E 
Sbjct: 354 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 413

Query: 93  AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
           A     EP P  P++    P P     AP   +  A     +AP   +EPS    +    
Sbjct: 414 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
             P  PA       A  T  + AP +  +P    + + AP++ + PA T   E   +TPK
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 529

Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
              P         + E+P P      AP    + T T  E
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P    E      +G       KE AP            
Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 631

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
                PK P  ++ AP       +    + A    +  AP   +EP+       K  AP 
Sbjct: 632 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 683

Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
            P   A  T  + AP +  KP   E AP++ + P +T +     +TPK   P  + +EP 
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 742

Query: 211 PV--EAPAANSDQT 222
           P   + PA  + +T
Sbjct: 743 PTTPKKPAPTTPET 756



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
           E A    KK      +E    TPKE  P    +PA     +  P    E       K   
Sbjct: 474 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 533

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
              EK A    E+     PE  E A     EP P  PE+       AA    PK  E A 
Sbjct: 534 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 589

Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
              +  AP   +EP+     PK+T AP  P   A  T  + AP +  KP   E AP++ +
Sbjct: 590 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646

Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
            P +T                           E   +TPK   P  + +EP P   + PA
Sbjct: 647 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 705

Query: 217 ANSDQTVTVK 226
                  T K
Sbjct: 706 PKELAPTTTK 715



 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
           K+       E A    K+     T+E   T  +S P    EPA     K  P    E  A
Sbjct: 301 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 359

Query: 67  EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
                E      KE AP   EP  T     A   P K        P P    E       
Sbjct: 360 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
             +P     PA    P+  +  P  T+ PA     +A  T  + +P +  +P  +   E 
Sbjct: 420 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 475

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
           AP++ + PA T   E   +TPK   P  + ++P P
Sbjct: 476 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 509



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
           TPK + P    EPA     KE      +G A     E      K+ APK   P  T+G  
Sbjct: 660 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 718

Query: 95  EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
              ++ P     ++ AP     PA       A      P    +E + P   +EP     
Sbjct: 719 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 778

Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
           S +E  P+ +  P   A + + K  G P +      + AA   + T  A +  +      
Sbjct: 779 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 833

Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
            P  +   PK  +  A  +++T   K
Sbjct: 834 TPETTTAAPKMTKETATTTEKTTESK 859



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)

Query: 34  EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
           E TPK  E+ P+    P        KP+     K  +K  E+D     E    APK   E
Sbjct: 790 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 847

Query: 89  K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
                   TE    A      +   +   P      +    APK          +     
Sbjct: 848 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 907

Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
            EE +K +     ++A      + TK+   P S  KP +       K TP   +  S+ P
Sbjct: 908 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 967

Query: 198 KAQGPAASAE 207
           +    +  AE
Sbjct: 968 ELNPTSRIAE 977


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)

Query: 10  KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
           K  N         D   E + T  + T  E++         + +GKEK     E ++ EK
Sbjct: 215 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 274

Query: 70  EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
              KD A       +  PKAE      A     EP     +E A+     P P     AP
Sbjct: 275 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 334

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
              +  A     +AP   +EP+    +      P  PA   TK      + S P +  E 
Sbjct: 335 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 394

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
           AP++ + PA T   E   +TPK   P    E     + PA
Sbjct: 395 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 434



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 305 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 363

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P     AP    E A    +  AP   +EP+    +      P
Sbjct: 364 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 423

Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             PA      A  T  + AP +  KP     AP++ + PA T     TPK   P  + +E
Sbjct: 424 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 472

Query: 209 PKPV----EAPAANSDQTVTVKE 227
           P P      AP        T KE
Sbjct: 473 PSPTTPKEPAPTTTKSAPTTTKE 495



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
           TPK+  P    EPA     KE      +  A     E      KE AP    K  P   E
Sbjct: 531 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589

Query: 92  GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
             A    E P     E+ AP            E A    ++AAP   +EP+    KE   
Sbjct: 590 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 649

Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
                     PK+T AP  P   A  T  + AP +  KP   E AP++ + P +T   + 
Sbjct: 650 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 708

Query: 193 PSSTPKAQGPAASAEEPKP 211
             +TPK   P  + +EP P
Sbjct: 709 APTTPKGTAP-TTPKEPAP 726



 Score = 54.7 bits (130), Expect = 6e-08
 Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           E A    KK      +E    TPKE  P    EP+     +  P          KE    
Sbjct: 440 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 499

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
              +    PK EP  T     A   P +        P P    E         AP  +  
Sbjct: 500 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558

Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
           PA           PK+T AP  P      T    AP +  KP  +   E AP++ E P  
Sbjct: 559 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 617

Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
           T   E   +TPKA  P  + +EP P
Sbjct: 618 TTPEEPAPTTPKAAAP-NTPKEPAP 641



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
           TPKE  P    EPA     KE      +G A     E      K+ APK        EP 
Sbjct: 643 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 701

Query: 89  KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
            T     A   P          P P    E         AP   +  AP   ++P+ +E 
Sbjct: 702 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 761

Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
            P  T+ P +  + +    T  + AP +  +P  +   + AP++ ETP  T +  STP  
Sbjct: 762 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 821

Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
                +  +      P  +++ T
Sbjct: 822 TKEPTTIHKSPDESTPELSAEPT 844



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 351 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 402

Query: 96  AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P    E AP   E A    +  AP A ++P+    +      P
Sbjct: 403 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 462

Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
             PA   TK + +P +  +P   ++++AP++ + PA T   S+  TPK   P  + +EP 
Sbjct: 463 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 520

Query: 211 P 211
           P
Sbjct: 521 P 521



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
           TPKE  P    EP      +  P          KE    A          EP  T   E 
Sbjct: 406 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 465

Query: 93  AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
           A     EP P  P++    P P     AP   +  A     +AP   +EPS    +    
Sbjct: 466 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 521

Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
             P  PA       A  T  + AP +  +P    + + AP++ + PA T   E   +TPK
Sbjct: 522 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 581

Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
              P         + E+P P      AP    + T T  E
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P    E      +G       KE AP            
Sbjct: 635 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 683

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
                PK P  ++ AP       +    + A    +  AP   +EP+       K  AP 
Sbjct: 684 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 735

Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
            P   A  T  + AP +  KP   E AP++ + P +T +     +TPK   P  + +EP 
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 794

Query: 211 PV--EAPAANSDQT 222
           P   + PA  + +T
Sbjct: 795 PTTPKKPAPTTPET 808



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
           E A    KK      +E    TPKE  P    +PA     +  P    E       K   
Sbjct: 526 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 585

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
              EK A    E+     PE  E A     EP P  PE+       AA    PK  E A 
Sbjct: 586 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 641

Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
              +  AP   +EP+     PK+T AP  P   A  T  + AP +  KP   E AP++ +
Sbjct: 642 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 698

Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
            P +T                           E   +TPK   P  + +EP P   + PA
Sbjct: 699 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 757

Query: 217 ANSDQTVTVK 226
                  T K
Sbjct: 758 PKELAPTTTK 767



 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
           K+       E A    K+     T+E   T  +S P    EPA     K  P    E  A
Sbjct: 353 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 411

Query: 67  EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
                E      KE AP   EP  T     A   P K        P P    E       
Sbjct: 412 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 471

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
             +P     PA    P+  +  P  T+ PA     +A  T  + +P +  +P  +   E 
Sbjct: 472 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 527

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
           AP++ + PA T   E   +TPK   P  + ++P P
Sbjct: 528 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 561



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
           TPK + P    EPA     KE      +G A     E      K+ APK   P  T+G  
Sbjct: 712 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 770

Query: 95  EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
              ++ P     ++ AP     PA       A      P    +E + P   +EP     
Sbjct: 771 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 830

Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
           S +E  P+ +  P   A + + K  G P +      + AA   + T  A +  +      
Sbjct: 831 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 885

Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
            P  +   PK  +  A  +++T   K
Sbjct: 886 TPETTTAAPKMTKETATTTEKTTESK 911



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)

Query: 34   EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
            E TPK  E+ P+    P        KP+     K  +K  E+D     E    APK   E
Sbjct: 842  EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 899

Query: 89   K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
                    TE    A      +   +   P      +    APK          +     
Sbjct: 900  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 959

Query: 138  GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
             EE +K +     ++A      + TK+   P S  KP +       K TP   +  S+ P
Sbjct: 960  PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1019

Query: 198  KAQGPAASAE 207
            +    +  AE
Sbjct: 1020 ELNPTSRIAE 1029


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)

Query: 10  KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
           K  N         D   E + T  + T  E++         + +GKEK     E ++ EK
Sbjct: 256 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 315

Query: 70  EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
              KD A       +  PKAE      A     EP     +E A+     P P     AP
Sbjct: 316 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 375

Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
              +  A     +AP   +EP+    +      P  PA   TK      + S P +  E 
Sbjct: 376 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 435

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
           AP++ + PA T   E   +TPK   P    E     + PA
Sbjct: 436 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 475



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 346 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 404

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P     AP    E A    +  AP   +EP+    +      P
Sbjct: 405 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 464

Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
             PA      A  T  + AP +  KP     AP++ + PA T     TPK   P  + +E
Sbjct: 465 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 513

Query: 209 PKPV----EAPAANSDQTVTVKE 227
           P P      AP        T KE
Sbjct: 514 PSPTTPKEPAPTTTKSAPTTTKE 536



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
           TPK+  P    EPA     KE      +  A     E      KE AP    K  P   E
Sbjct: 572 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630

Query: 92  GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
             A    E P     E+ AP            E A    ++AAP   +EP+    KE   
Sbjct: 631 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 690

Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
                     PK+T AP  P   A  T  + AP +  KP   E AP++ + P +T   + 
Sbjct: 691 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 749

Query: 193 PSSTPKAQGPAASAEEPKP 211
             +TPK   P  + +EP P
Sbjct: 750 APTTPKGTAP-TTPKEPAP 767



 Score = 54.7 bits (130), Expect = 6e-08
 Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           E A    KK      +E    TPKE  P    EP+     +  P          KE    
Sbjct: 481 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 540

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
              +    PK EP  T     A   P +        P P    E         AP  +  
Sbjct: 541 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599

Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
           PA           PK+T AP  P      T    AP +  KP  +   E AP++ E P  
Sbjct: 600 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 658

Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
           T   E   +TPKA  P  + +EP P
Sbjct: 659 TTPEEPAPTTPKAAAP-NTPKEPAP 682



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
           TPKE  P    EPA     KE      +G A     E      K+ APK        EP 
Sbjct: 684 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 742

Query: 89  KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
            T     A   P          P P    E         AP   +  AP   ++P+ +E 
Sbjct: 743 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 802

Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
            P  T+ P +  + +    T  + AP +  +P  +   + AP++ ETP  T +  STP  
Sbjct: 803 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 862

Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
                +  +      P  +++ T
Sbjct: 863 TKEPTTIHKSPDESTPELSAEPT 885



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P          KE       +    PK EP  T     
Sbjct: 392 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 443

Query: 96  AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
           A   P +        P P    E AP   E A    +  AP A ++P+    +      P
Sbjct: 444 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 503

Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
             PA   TK + +P +  +P   ++++AP++ + PA T   S+  TPK   P  + +EP 
Sbjct: 504 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 561

Query: 211 P 211
           P
Sbjct: 562 P 562



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
           TPKE  P    EP      +  P          KE    A          EP  T   E 
Sbjct: 447 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 506

Query: 93  AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
           A     EP P  P++    P P     AP   +  A     +AP   +EPS    +    
Sbjct: 507 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 562

Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
             P  PA       A  T  + AP +  +P    + + AP++ + PA T   E   +TPK
Sbjct: 563 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 622

Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
              P         + E+P P      AP    + T T  E
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662



 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
           TPKE  P    EPA     +  P    E      +G       KE AP            
Sbjct: 676 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 724

Query: 96  AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
                PK P  ++ AP       +    + A    +  AP   +EP+       K  AP 
Sbjct: 725 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 776

Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
            P   A  T  + AP +  KP   E AP++ + P +T +     +TPK   P  + +EP 
Sbjct: 777 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 835

Query: 211 PV--EAPAANSDQT 222
           P   + PA  + +T
Sbjct: 836 PTTPKKPAPTTPET 849



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)

Query: 17  EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
           E A    KK      +E    TPKE  P    +PA     +  P    E       K   
Sbjct: 567 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 626

Query: 69  KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
              EK A    E+     PE  E A     EP P  PE+       AA    PK  E A 
Sbjct: 627 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 682

Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
              +  AP   +EP+     PK+T AP  P   A  T  + AP +  KP   E AP++ +
Sbjct: 683 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 739

Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
            P +T                           E   +TPK   P  + +EP P   + PA
Sbjct: 740 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 798

Query: 217 ANSDQTVTVK 226
                  T K
Sbjct: 799 PKELAPTTTK 808



 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
           K+       E A    K+     T+E   T  +S P    EPA     K  P    E  A
Sbjct: 394 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 452

Query: 67  EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
                E      KE AP   EP  T     A   P K        P P    E       
Sbjct: 453 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 512

Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
             +P     PA    P+  +  P  T+ PA     +A  T  + +P +  +P  +   E 
Sbjct: 513 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 568

Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
           AP++ + PA T   E   +TPK   P  + ++P P
Sbjct: 569 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 602



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)

Query: 36  TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
           TPK + P    EPA     KE      +G A     E      K+ APK   P  T+G  
Sbjct: 753 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 811

Query: 95  EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
              ++ P     ++ AP     PA       A      P    +E + P   +EP     
Sbjct: 812 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 871

Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
           S +E  P+ +  P   A + + K  G P +      + AA   + T  A +  +      
Sbjct: 872 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 926

Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
            P  +   PK  +  A  +++T   K
Sbjct: 927 TPETTTAAPKMTKETATTTEKTTESK 952



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)

Query: 34   EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
            E TPK  E+ P+    P        KP+     K  +K  E+D     E    APK   E
Sbjct: 883  EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 940

Query: 89   K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
                    TE    A      +   +   P      +    APK          +     
Sbjct: 941  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 1000

Query: 138  GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
             EE +K +     ++A      + TK+   P S  KP +       K TP   +  S+ P
Sbjct: 1001 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1060

Query: 198  KAQGPAASAE 207
            +    +  AE
Sbjct: 1061 ELNPTSRIAE 1070


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
           sapiens]
          Length = 2524

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 67/237 (28%), Positives = 92/237 (38%), Gaps = 31/237 (13%)

Query: 16  DEKAKEKDKKAEGAATEEEGTP---KESEPQAAA---------EPAEA--KEGKEKPDQD 61
           +  A+ K KKA  AA+EE   P   ++ E +A+          E AEA    G E P  +
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGE 735

Query: 62  AEGKAE-------EKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGP 113
             G A        E        AAK+      +P  T GA      PP  P ++  AP  
Sbjct: 736 CSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPT- 794

Query: 114 AAGGEAPKAAEAAAAPAESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDS 172
               E   A+EA  AP    AP +   P      E K+ E  AAP  +E +    PA++ 
Sbjct: 795 ----EPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEE 850

Query: 173 ---KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
                G +E    S+ T  A E P+    A+   A+AE     E     S +  T K
Sbjct: 851 LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 907



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 71/258 (27%), Positives = 90/258 (34%), Gaps = 79/258 (30%)

Query: 34   EGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKDAAAAKEEAPKAEPEK 89
            E  P  +EP  A+E   A      P   +        EEKE E  AA   EE  + +P  
Sbjct: 788  EDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA 847

Query: 90   TEGAA--EAKAEPPKAPE-QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE------ 140
             E  A    KAE P   E  E+A  GPA G    K AEAA A AE A  A  +E      
Sbjct: 848  AEELAVDTGKAEEPVKSECTEEAEEGPAKG----KDAEAAEATAEGALKAEKKEGGSGRA 903

Query: 141  -PSKEEGEPKKTEAPAAPAAQE----------------------TKSDGAPASDSKP--- 174
              +K  G P+ +++ A  +A E                      T    A AS  KP   
Sbjct: 904  TTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 963

Query: 175  --------------------GSSEAAPSSKETPA------------ATEAPSSTPKAQG- 201
                                   +AAP+    PA            A + P S+P+ +  
Sbjct: 964  KQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSR 1023

Query: 202  ---PAASAEEPKPVEAPA 216
               P A  E  KPV  PA
Sbjct: 1024 SPAPPADKEAEKPVFFPA 1041



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 49/170 (28%), Positives = 67/170 (39%), Gaps = 29/170 (17%)

Query: 70  EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
           E E++A   K++AP A       A+E  A PP   ++E  A G  +G E     EA A  
Sbjct: 674 EKERNARRKKKKAPAA-------ASEEAAFPPVVEDEEMEASG-VSGNEEEMVEEAEALH 725

Query: 130 A--------ESAAPAAGEEPSKEEGEPKK-TEA--------PAAPAAQETKSDGAPASDS 172
           A        E + PA     S  E  P   TEA        P  PA     +DG P    
Sbjct: 726 ASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPAT--LGADGPPPGPP 783

Query: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
            P   +    ++ TPA+    + TP    P+ SA  P PV       ++T
Sbjct: 784 TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSA--PPPVVPKEEKEEET 831



 Score = 36.2 bits (82), Expect = 0.024
 Identities = 28/141 (19%), Positives = 62/141 (43%), Gaps = 10/141 (7%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
           L+KK + Y    +    +  +  G + +++   ++ + Q   +P      +EK +++ E 
Sbjct: 472 LTKKNENY----KSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK 527

Query: 65  KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA-- 122
           +AE++E + +    KE+  K + + T G    + E   +  ++ A       G   ++  
Sbjct: 528 EAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMA 587

Query: 123 ----AEAAAAPAESAAPAAGE 139
               +E A  P +SA  A+ E
Sbjct: 588 NEANSEEAITPQQSAELASME 608



 Score = 28.5 bits (62), Expect = 4.9
 Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 4/104 (3%)

Query: 33   EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
            E+  P +  P A   P   +   + P Q       +       A  + E P   P     
Sbjct: 986  EDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFP---AF 1042

Query: 93   AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP-AESAAP 135
            AAEA+  P   P      P P    E  KA+  A  P A S AP
Sbjct: 1043 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAP 1086


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 64/216 (29%), Positives = 89/216 (41%), Gaps = 30/216 (13%)

Query: 13  NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE 72
           +V +++   K++ +   A   E    + +P+AA E    KE K KP    E K EEKE  
Sbjct: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP----EDKKEEKEKP 656

Query: 73  KDAAAAKE--------EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
           K   A KE        E PK E  K E   E K E  K P++E     P      PK  +
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP------PKEVK 710

Query: 125 AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSS--EAAPS 182
                 E       +E  KEE EPKK E    P  ++ K    P S++K  ++     P 
Sbjct: 711 KEVKKEEK------KEVKKEEKEPKK-EIKKLP--KDAKKSSTPLSEAKKPAALKPKVPK 761

Query: 183 SKETPAATEAPSSTPKAQGP-AASAEEPKPVEAPAA 217
            +E+       +  PK +G      +E K  EA AA
Sbjct: 762 KEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAA 797



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 58/209 (27%), Positives = 92/209 (44%), Gaps = 15/209 (7%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK---EGKEKPDQDAEG 64
           +K+  +V  + AKEK  K E     E+   ++ +P+      E K   + +EKP ++   
Sbjct: 622 EKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVK 681

Query: 65  KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
           K  +KE +K+     ++  K E    E   E K E  K  ++E+  P      + PK A+
Sbjct: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI-KKLPKDAK 740

Query: 125 AAAAP-AESAAPAA--GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG-SSEAA 180
            ++ P +E+  PAA   + P KEE   K + A   P     K  G      K G ++EA 
Sbjct: 741 KSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP-----KEKGKIKVIKKEGKAAEAV 795

Query: 181 PSSKETPAATEAPSSTP--KAQGPAASAE 207
            ++  T A T A  +     A GPA   E
Sbjct: 796 AAAVGTGATTAAVMAAAGIAAIGPAKELE 824



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 45/188 (23%), Positives = 79/188 (42%), Gaps = 5/188 (2%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKE-KPDQDAEGKAEEKEGEKD 74
           ++K +EK+K  +  A +E+ TP + E +   E  + +  KE K ++  E K E K+    
Sbjct: 647 EDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA- 133
               KE   + + E  +   E K E  K P+  + +  P +  + P A +      E + 
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766

Query: 134 ---APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAAT 190
              + AAG+   K + +  K E  AA A       GA  +     +  AA    +   A 
Sbjct: 767 KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE 826

Query: 191 EAPSSTPK 198
            +  S+P+
Sbjct: 827 RSLMSSPE 834



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 58/243 (23%), Positives = 90/243 (37%), Gaps = 39/243 (16%)

Query: 4    KLSKKKKGYNVNDEKA--KEKDKKAEGAATEEEG-----------TPKESEPQAAAEPAE 50
            K   +  G+  + E    +EK +  E    EE+G           +P E E  A AE   
Sbjct: 925  KFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADA 984

Query: 51   AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA 110
                K +     + +AEE   + D A  K EA ++E E  E   E KAE  +  E E   
Sbjct: 985  YIREKRESVASGDDRAEE---DMDEAIEKGEAEQSEEEADE---EDKAEDAREEEYEP-- 1036

Query: 111  PGPAAGGEAPKAAEAAAAPAESAAPAAGEE--------PSKEEGEPKKTEAPAAPAAQET 162
                   E  +A +   A  + AA A G E        P+K+ G       PA+    ET
Sbjct: 1037 -------EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDET 1089

Query: 163  KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE---PKPVEAPAANS 219
               G+ +  +           +E  A +    ST +        +E   P+ V +   N+
Sbjct: 1090 LPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN 1149

Query: 220  DQT 222
            ++T
Sbjct: 1150 EET 1152



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 44/209 (21%), Positives = 76/209 (36%), Gaps = 17/209 (8%)

Query: 27   EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
            E A  E +   +E     A+    A+E  ++  +  E +  E+E +++  A      + E
Sbjct: 976  ESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYE 1035

Query: 87   PEKTEGAAEAKAEPPKAPE----QEQ----AAPGPAAGGEAPKAAEAAA-----APAESA 133
            PEK E      A   KA E    +EQ      P    G ++P    A++      P  S 
Sbjct: 1036 PEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSE 1095

Query: 134  APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAP 193
            + A   +    E +P++  A +       +    P    +  +     S +     TE+P
Sbjct: 1096 SEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESP 1155

Query: 194  S----STPKAQGPAASAEEPKPVEAPAAN 218
            S    +  K +    S E  KP +    N
Sbjct: 1156 SQEFVNITKYESSLYSQEYSKPADVTPLN 1184



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 39/248 (15%)

Query: 5   LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
           + K++K      +K  +K+ K E     ++   KE+ P+   +  + +E KE   ++ E 
Sbjct: 669 IKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEP 728

Query: 65  KAEEKEGEKDA-------------AAAKEEAPKAEPE-----------KTEGAAEAKAEP 100
           K E K+  KDA             AA K + PK E             K +G  +   + 
Sbjct: 729 KKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE 788

Query: 101 PKAPEQEQAAPGPAAGGEAPKAAEAAAA-------PAESAAPAAGEEPSKEEGEPKKTEA 153
            KA E   AA G  A   A  AA   AA        AE +  ++ E+ +K+  E K  E 
Sbjct: 789 GKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEV 848

Query: 154 PAAPAAQ---ETKSDGAPASDSKPGSSEAAPSSKE-TPAATEAPS---STPKAQGPA-AS 205
                 +   E   D     +++P  +      +E T    E+P    +T + +G    +
Sbjct: 849 DVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQT 908

Query: 206 AEEPKPVE 213
            EE +PVE
Sbjct: 909 PEELEPVE 916



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 55/233 (23%), Positives = 92/233 (39%), Gaps = 35/233 (15%)

Query: 19   AKEKDKKAEGAATEEEGTPK------------ESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
            ++E  +++E   T+  G P             E+ P + +E A ++   + P +  E  +
Sbjct: 2112 SEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPS 2171

Query: 67   EEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
               +   D+    E  P    +KT        +PP AP Q+++ P P     +    EA 
Sbjct: 2172 ITADANIDSEDESETIPT---DKT--VTYKHMDPPPAPVQDRS-PSPRHPDVSMVDPEAL 2225

Query: 127  AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP---ASDSKPG-------- 175
            A   E     A ++  KE+ + KK       ++   KSDG     A+  KP         
Sbjct: 2226 AI--EQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDK 2283

Query: 176  -SSEAAPSSKETPAATEAPSSTPK---AQGPAASAEEPKPVEAPAANSDQTVT 224
             S  A+P  KE+      P++TP+   A+G     E      A A+ S +T T
Sbjct: 2284 VSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTAT 2336



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 49/190 (25%), Positives = 76/190 (40%), Gaps = 32/190 (16%)

Query: 22   KDKKAEGAATEEEGTPKESEPQAA----AEPAEAKEGKEKPDQ-----DAEGKAE----- 67
            KD K +    E+E   KE+EP  A     E    K   E PD+     + EG+ E     
Sbjct: 852  KDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEE 911

Query: 68   ----EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQ----------AAPGP 113
                EK+G  D    ++E    E     G  E KAE  +A E E+          +   P
Sbjct: 912  LEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSP 971

Query: 114  AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG----EPKKTEAPAAPAAQETKSDGAPA 169
                E+ KA   A    +  + A+G++ ++E+     E  + E     A +E K++ A  
Sbjct: 972  TEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031

Query: 170  SDSKPGSSEA 179
             + +P   EA
Sbjct: 1032 EEYEPEKMEA 1041



 Score = 41.2 bits (95), Expect = 7e-04
 Identities = 51/211 (24%), Positives = 79/211 (37%), Gaps = 27/211 (12%)

Query: 21  EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
           EK  K E   ++E+   K+ +P          E KE P ++     + +  EK A   K 
Sbjct: 575 EKPPKVE---SKEKVMVKKDKPIKTETKPSVTE-KEVPSKEEPSPVKAEVAEKQATDVK- 629

Query: 81  EAPKAEPEK-----TEGAAEAKAEPPKAPEQEQAA---PGPAAGGEAPKAAEAAAAPAES 132
             PKA  EK     T+   E K E  + P++E A      P    E PK  E      + 
Sbjct: 630 --PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKE 687

Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
                 +EP KE     K E P     +E K +     + K    E     KE     + 
Sbjct: 688 IKKEEKKEPKKE----VKKETPPKEVKKEVKKE-----EKKEVKKEEKEPKKE---IKKL 735

Query: 193 PSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
           P    K+  P + A++P  ++      +++V
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 21/140 (15%)

Query: 18   KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
            KA +KD K E   T++ GT  +S     + P +  +GK KP   +   A  KE     + 
Sbjct: 2233 KALKKDLK-EKTKTKKPGTKTKS-----SSPVKKSDGKSKPLAASPKPAGLKESSDKVSR 2286

Query: 78   AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
                   A P+K E + E  A+P   PE  +AA G     E   AA A+A+ +   A A 
Sbjct: 2287 V------ASPKKKE-SVEKAAKPTTTPE-VKAARGEEKDKETKNAANASASKSAKTATAG 2338

Query: 138  GEEPSKEEGEPKKTEAPAAP 157
                    G  K T++ A P
Sbjct: 2339 -------PGTTKTTKSSAVP 2351



 Score = 37.7 bits (86), Expect = 0.008
 Identities = 29/92 (31%), Positives = 35/92 (38%), Gaps = 8/92 (8%)

Query: 131 ESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAAT 190
           ES  PAA   PSK   +  K E P        +         K  S E     K+ P  T
Sbjct: 543 ESLKPAAKPLPSKSVRKESKEETPEVTKVNHVE------KPPKVESKEKVMVKKDKPIKT 596

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
           E   S  + + P  S EEP PV+A  A    T
Sbjct: 597 ETKPSVTEKEVP--SKEEPSPVKAEVAEKQAT 626



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 39/185 (21%), Positives = 74/185 (40%), Gaps = 16/185 (8%)

Query: 21   EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK-PDQ---DAEGKAEEKEGEKDAA 76
            + + ++E   T++  T K  +P  A  P + +    + PD    D E  A E+   K   
Sbjct: 2179 DSEDESETIPTDKTVTYKHMDPPPA--PVQDRSPSPRHPDVSMVDPEALAIEQNLGK--- 2233

Query: 77   AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQ----AAPGPAAGGEAPKAAEAAAAPAES 132
            A K++  +    K  G     + P K  + +     A+P PA   E+       A+P + 
Sbjct: 2234 ALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKK 2293

Query: 133  AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
             +    E+ +K    P+   A      +ETK+    ++     ++ A P + +T  ++  
Sbjct: 2294 ESV---EKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAV 2350

Query: 193  PSSTP 197
            P   P
Sbjct: 2351 PPGLP 2355


>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
          Length = 437

 Score = 62.4 bits (150), Expect = 3e-10
 Identities = 52/205 (25%), Positives = 88/205 (42%), Gaps = 13/205 (6%)

Query: 28  GAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQD-AEGKAEEKEGEKDAAAAKEEAPKAE 86
           G +T+    P+  +   +   AEA+  ++ P++  AE K ++    K  A AK +  K  
Sbjct: 51  GGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQ--KGS 108

Query: 87  PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE--PSKE 144
             K+   A+   +       E   P  + G    +A     +P  S A A  ++  PSK 
Sbjct: 109 TSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKS 168

Query: 145 EGEPKKT-EAPAAPAAQ-ETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGP 202
             E + T + P    A  +T  DG+    SK G+ +  P  K+ P  + A   TPK    
Sbjct: 169 GSEAQTTKDVPNKSGADGQTPKDGS----SKSGAEDQTP--KDVPNKSGAEKQTPKDGSN 222

Query: 203 AASAEEPKPVEAPAANSDQTVTVKE 227
            + AEE  P++ P+ +  +  T K+
Sbjct: 223 KSGAEEQGPIDGPSKSGAEEQTSKD 247



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 49/233 (21%), Positives = 92/233 (39%), Gaps = 26/233 (11%)

Query: 8   KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG-KA 66
           ++ G +       +  K +   ++ E  TP+++  ++ AE    K+   K   +A+  K 
Sbjct: 48  QRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKG 107

Query: 67  EEKEGEKDAAAAKEEAPKAEPE-----KTEGAAEAKAEPPK-------APEQEQAAPGPA 114
              +   +A   K+   K+ PE      + G + A+A+ P+       A  + Q      
Sbjct: 108 STSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSK 167

Query: 115 AGGEAPKAAEAA-AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSK 173
           +G EA    +    + A+   P  G   S  E +  K     + A ++T  DG+    +K
Sbjct: 168 SGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGS----NK 223

Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP------KPVEAPAANSD 220
            G+ E  P   + P+ + A   T K        E+P      KP+  P+ N +
Sbjct: 224 SGAEEQGPI--DGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKE 274



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 47/202 (23%), Positives = 76/202 (37%), Gaps = 17/202 (8%)

Query: 42  PQAAAEPAEAKEGKEKPDQ---DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA 98
           P  A E  + +E   +P            ++ G    +  + + PK  P K+   A+   
Sbjct: 19  PLLATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPE 78

Query: 99  EPPK---APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGE---PK--- 149
           + P    A  + Q      +G EA K  + + + + S A    +  SK   E   PK   
Sbjct: 79  DTPNKSGAEAKTQKDSSNKSGAEA-KTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDST 137

Query: 150 -KTEAPAAPAAQETKSDGAPA---SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAAS 205
            K+ A A          GA A    DS   S   A ++K+ P  + A   TPK     + 
Sbjct: 138 GKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSG 197

Query: 206 AEEPKPVEAPAANSDQTVTVKE 227
           AE+  P + P  +  +  T K+
Sbjct: 198 AEDQTPKDVPNKSGAEKQTPKD 219



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 42/182 (23%), Positives = 76/182 (41%), Gaps = 21/182 (11%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE--EKEGEKDAAAAK 79
           KD  ++  A  E+ TPK+   ++ AE    K+G  K   + +G  +   K G ++  + K
Sbjct: 190 KDGSSKSGA--EDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTS-K 246

Query: 80  EEAPKAEPEKTEGAAEAKA--------EPPKAPEQEQAAPGPAA-------GGEAPKAAE 124
           +   K  PE+      +K         E PKA   + A  G  +        GE      
Sbjct: 247 DSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLIS 306

Query: 125 AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSS 183
                 +S+ P    EP + E +    E  + P  ++ K  G+ +S+++ G+ S++  S 
Sbjct: 307 PPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSE 366

Query: 184 KE 185
           K+
Sbjct: 367 KD 368



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 47/235 (20%), Positives = 89/235 (37%), Gaps = 17/235 (7%)

Query: 3   GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP-----------AEA 51
           G  +K +KG         +  K +   +  E  TPK+S  ++ AE            AEA
Sbjct: 99  GAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEA 158

Query: 52  KEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP 111
           K  K+ P +    +A+  +   + + A  + PK    K+    +   + P     E+  P
Sbjct: 159 KTQKDSPSKSG-SEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTP 217

Query: 112 GPAAGGEAPKAAEAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
              +     +       P++S A    + + P+K   E    +  + P +  + +   P 
Sbjct: 218 KDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPK 277

Query: 170 SDSK--PGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
           +D+       + +P + +T +  E    +P  Q    S+E  + VE   A  D T
Sbjct: 278 ADTNQLADKGKLSPHAFKTESGEETDLISP-PQEEVKSSEPTEDVEPKEAEDDDT 331



 Score = 35.0 bits (79), Expect = 0.053
 Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 29/174 (16%)

Query: 33  EEGTPKESEPQAAAEP-----------AEAKEGKEKPDQDAEGKAEEKEGEKDAA--AAK 79
           E+ TPK+   ++ AE            AE +  K+ P++    +   K+  K  +  +  
Sbjct: 213 EKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDN 272

Query: 80  EEAPKAEPE-------------KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
           +E PKA+               KTE   E     P  P++E  +  P    E  +A +  
Sbjct: 273 KELPKADTNQLADKGKLSPHAFKTESGEETDLISP--PQEEVKSSEPTEDVEPKEAEDDD 330

Query: 127 AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
             P E + P   +E        +  E   + +    K D  P + S  GS+E++
Sbjct: 331 TGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYP-NGSGNGSAESS 383


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 63/211 (29%), Positives = 94/211 (44%), Gaps = 24/211 (11%)

Query: 26  AEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE---EKEGEKDAAAAKEE 81
           AE A TE +   PKE+  + A+   +     E P  +   +A     +E   + A A+ +
Sbjct: 450 AEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQ 509

Query: 82  APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAA--APAESAAPAAG- 138
           +P AE    E   EA AE       E  A    A  ++P + E +A  APAE  +P+A  
Sbjct: 510 SPLAEETTAE---EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKG 566

Query: 139 ----------EEPSKEEGEPKKTEAP-AAPAAQETKSDGAPASDSKPGSSEAAPSSKETP 187
                     + PS EE   ++  A     AA E  ++ APA + +P  +E AP+  + P
Sbjct: 567 VSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPA-EVQPPPAEEAPAEVQPP 625

Query: 188 AATEAPSST--PKAQGPAASAEEPKPVEAPA 216
            A EAP+    P A+   A  + P   EAPA
Sbjct: 626 PAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 656



 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 66/222 (29%), Positives = 92/222 (41%), Gaps = 31/222 (13%)

Query: 22  KDKKAEGAATEEEGTPKESEPQAAAEPAEAKE--GKEKPDQDA----------EGKAEEK 69
           K+  AE A+ E +     +EP A   PAEA+    +E   ++A          E  AEE 
Sbjct: 463 KETTAEEASAEIQ-LLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEA 521

Query: 70  EGEKDAAAAKEEAPKAEPEKTEG--AAEAKAEPPKAPEQEQAAPG-----------PAAG 116
             E    AA E      P + +   + E  AE   A  Q  +A G           P +G
Sbjct: 522 SAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSG 581

Query: 117 GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS 176
            E      +AA    +A  A+ EE   E   P   EAPA    Q   ++ APA + +P  
Sbjct: 582 EETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAE--VQPPPAEEAPA-EVQPPP 638

Query: 177 SEAAPSSKETPAATEAPSST--PKAQGPAASAEEPKPVEAPA 216
           +E AP+  + P A EAP+    P A+   A  + P   EAPA
Sbjct: 639 AEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 680



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 67/223 (30%), Positives = 100/223 (44%), Gaps = 28/223 (12%)

Query: 14  VNDEKAKEKDKKAEGAATEEEGTPKESEPQ-----AAAEPAEAKEGKEKPDQDAEGKAEE 68
           +++E + E+      +   EE T +E+  +     A   PA+    + +     E  AEE
Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEE 554

Query: 69  KEGEKDAAAAK----EEAP-KAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
              E  + +AK    EEAP + +P   E   E  AE   A  Q  AA   A+  EAP   
Sbjct: 555 APAEVQSPSAKGVSIEEAPLELQPPSGE---ETTAEEASAAIQLLAAT-EASAEEAPAEV 610

Query: 124 E---AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
           +   A  APAE   P A E P++ +  P + EAPA    Q   ++ APA + +P  +E A
Sbjct: 611 QPPPAEEAPAEVQPPPAEEAPAEVQPPPAE-EAPAE--VQPPPAEEAPA-EVQPPPAEEA 666

Query: 181 PSSKETPAATEAPS---STPKAQGP----AASAEEPKPVEAPA 216
           P+  + P A EAP+   S P  + P     A+   P   + PA
Sbjct: 667 PAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPA 709



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 57/206 (27%), Positives = 85/206 (41%), Gaps = 32/206 (15%)

Query: 42  PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE---AKA 98
           P A   P+E    +  P    +  + E  GE  + +A++   + +P   EGA E   AK 
Sbjct: 353 PSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKV 412

Query: 99  EPPKAPEQEQAAPGPAAGGEAPKA------------AEAAAAPAESAAPAAGEEPSKEEG 146
           EPP   E+  A   P    EAP+               A  AP E  +P   E  ++E  
Sbjct: 413 EPPTV-EETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEAS 471

Query: 147 ---------EPKKTEAPA---APAAQETKSDGAPASDSKP----GSSEAAPSSKETPAAT 190
                    EP   E PA   +P ++ET ++ A A    P     ++E A +  +  AA 
Sbjct: 472 AEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAI 531

Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
           EAP+    A+  +  +EE    EAPA
Sbjct: 532 EAPADETPAEAQSPLSEETSAEEAPA 557



 Score = 52.0 bits (123), Expect = 4e-07
 Identities = 58/204 (28%), Positives = 83/204 (40%), Gaps = 13/204 (6%)

Query: 13  NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP-AEAKEGKEKPDQDAEGKAEEKEG 71
           +  +  A+ +   A+G + EE   P E +P +  E  AE      +     E  AEE   
Sbjct: 551 SAEEAPAEVQSPSAKGVSIEE--APLELQPPSGEETTAEEASAAIQLLAATEASAEEAPA 608

Query: 72  EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           E     A+E   + +P   E  A A+ +PP A E+  A   P    EAP  AE    PAE
Sbjct: 609 EVQPPPAEEAPAEVQPPPAE-EAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAE 664

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPA--APAAQETKSDGAPASDSKPGSSEAAPSSKETPAA 189
             APA  + P  EE   +    PA   P  +   +  +P +D  P + EA+      PA 
Sbjct: 665 E-APAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVP-AEEASVDKHSPPAD 722

Query: 190 TEAPSSTPKAQGPAASAEEPKPVE 213
                  P   G A++   P P E
Sbjct: 723 LLLTEEFP--IGEASAEVSPPPSE 744



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 54/197 (27%), Positives = 79/197 (40%), Gaps = 16/197 (8%)

Query: 18  KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
           +A   +  AE  +   E T  E  P     P+      E+   + +  + E+   ++A+A
Sbjct: 532 EAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASA 591

Query: 78  AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
           A +     E    E  AE   +PP A E+  A   P    EAP  AE    PAE A PA 
Sbjct: 592 AIQLLAATEASAEEAPAEV--QPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAEEA-PAE 645

Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS----KETPAATEAP 193
            + P  EE   +    PA  A  E +    P ++  P   ++ P+     +ET AA  +P
Sbjct: 646 VQPPPAEEAPAEVQPPPAEEAPAEVQ---PPPAEEAPAEVQSLPAEETPIEETLAAVHSP 702

Query: 194 SSTPKAQGPAASAEEPK 210
              P    PA  A   K
Sbjct: 703 ---PADDVPAEEASVDK 716



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 53/192 (27%), Positives = 71/192 (36%), Gaps = 10/192 (5%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
           DE   E         + EE   +   P A     E    + +P    E  AEE       
Sbjct: 536 DETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQL 595

Query: 76  AAAKEEAPKAEPEKTEGA----AEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
            AA E + +  P + +      A A+ +PP A E+  A   P    EAP  AE    PAE
Sbjct: 596 LAATEASAEEAPAEVQPPPAEEAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAE 652

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
            A PA  + P  EE   +    PA  A  E +S   PA ++    + AA  S        
Sbjct: 653 EA-PAEVQPPPAEEAPAEVQPPPAEEAPAEVQS--LPAEETPIEETLAAVHSPPADDVPA 709

Query: 192 APSSTPKAQGPA 203
             +S  K   PA
Sbjct: 710 EEASVDKHSPPA 721



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 49/194 (25%), Positives = 76/194 (39%), Gaps = 15/194 (7%)

Query: 33  EEGTPKESEPQAAAEPAEAKE--GKEKPD--QDAEGKAEEKEGEK---DAAAAKEEAPKA 85
           +EG+  +    A  EP   ++   K +P   ++A  KAE +  E+       + EE P A
Sbjct: 244 QEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDA 303

Query: 86  EPEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
           E          K +PP A E    +  A   P +  E+P     A     SA  +  EEP
Sbjct: 304 EAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEP 363

Query: 142 SKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG 201
             E   P   ++P+     E +S  A  +  +     A  + +E PA  E P+     + 
Sbjct: 364 PAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPT----VEE 419

Query: 202 PAASAEEPKPVEAP 215
             A  +   P EAP
Sbjct: 420 TLADVQPLLPEEAP 433



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 49/196 (25%), Positives = 74/196 (37%), Gaps = 20/196 (10%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
           +E   E+   A       E + +E+  +    PAE    + +P    E  AE +    + 
Sbjct: 582 EETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEE 641

Query: 76  AAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA-- 133
           A A+ + P AE       A A+ +PP A E+  A   P    EAP  AE  + PAE    
Sbjct: 642 APAEVQPPPAE------EAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQSLPAEETPI 692

Query: 134 --------APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
                   +P A + P+ EE    K   PA     E    G  +++  P  SE  P  + 
Sbjct: 693 EETLAAVHSPPADDVPA-EEASVDKHSPPADLLLTEEFPIGEASAEVSPPPSEQTPEDEA 751

Query: 186 TPAATEAPSSTPKAQG 201
                     +P+  G
Sbjct: 752 LVENVSTEFQSPQVAG 767



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 50/180 (27%), Positives = 69/180 (38%), Gaps = 28/180 (15%)

Query: 67  EEKEGEKDAAAAKEEAPKAE--PEKTEGA----AEAKAEPPKA--------PEQEQAAPG 112
           +E    K  A+A+ E P  E  P K +      A AKAEP  A        P  E+    
Sbjct: 244 QEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDA 303

Query: 113 PAAGGEAPKAAEAAAAPAESAA----PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
            AA   A  + +    PAE A     PA  + PS EE    +  A   P + E      P
Sbjct: 304 EAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEP 363

Query: 169 ASDSKPGSSEAAPSSK-----ETPAATEAPSSTPKAQGPAASAE-----EPKPVEAPAAN 218
            ++  P  +E +PS +      +P+A +AP          A  E     EP  VE   A+
Sbjct: 364 PAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLAD 423



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 58/224 (25%), Positives = 82/224 (36%), Gaps = 19/224 (8%)

Query: 13  NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE 72
           +V  + + E+   AE A    E + K   P A   P      + +P    E  + E   E
Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349

Query: 73  KDAAAAKE---EAPKAE----PEKTEGAAEAKAE-----PPKAPEQEQAAPGPAAGGEAP 120
               +A+E   E P AE    P +   + E   E       KAP + Q  P   A  EAP
Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409

Query: 121 KAAEAAAAPAESA--APAAGEEPSKEEGEPKKT----EAPAAPAAQETKSDGAPASDSKP 174
              E        A   P   EE  +EE    +     E PA  A  E +S     + ++ 
Sbjct: 410 AKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEE 469

Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP-KPVEAPAA 217
            S+E    +   P A E P+          SAEE    V++P A
Sbjct: 470 ASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLA 513



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 55/193 (28%), Positives = 79/193 (40%), Gaps = 15/193 (7%)

Query: 26  AEGAATEEEGTPKESEPQAAAEPAEAKEG---KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
           AEGA  E    P + EP    E     +    +E P ++A         E  A  A  E 
Sbjct: 401 AEGALEE---APAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEF 457

Query: 83  PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAA--APAESAAPAAGEE 140
               P++T  A EA AE       E  A    A   +P + E +A  A AE  +P A E 
Sbjct: 458 QSPLPKETT-AEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEET 516

Query: 141 PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAA-----TEAPSS 195
            ++E     +  A     A ET ++ A +  S+  S+E AP+  ++P+A      EAP  
Sbjct: 517 TAEEASAEIQLLAAIEAPADETPAE-AQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLE 575

Query: 196 TPKAQGPAASAEE 208
                G   +AEE
Sbjct: 576 LQPPSGEETTAEE 588



 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 50/203 (24%), Positives = 77/203 (37%), Gaps = 14/203 (6%)

Query: 6   SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAKEGKEKPDQDAE 63
           S   KG ++ +   + +    E    EE     +  +  +A+AE A A+    +P    E
Sbjct: 561 SPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEV---QPPPAEE 617

Query: 64  GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
             AE +    + A A+ + P AE       A A+ +PP A E+  A   P    EAP  A
Sbjct: 618 APAEVQPPPAEEAPAEVQPPPAE------EAPAEVQPPPA-EEAPAEVQPPPAEEAP--A 668

Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
           E    PAE A       P++E    +   A  +P A +  ++ A      P +       
Sbjct: 669 EVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEE 728

Query: 184 KETPAATEAPSSTPKAQGPAASA 206
                A+   S  P  Q P   A
Sbjct: 729 FPIGEASAEVSPPPSEQTPEDEA 751



 Score = 37.4 bits (85), Expect = 0.011
 Identities = 53/226 (23%), Positives = 82/226 (36%), Gaps = 35/226 (15%)

Query: 32  EEEGTPKESEPQAAAEPAEAKEGKEKPD---QDAEGK--AEEKEGEKDAAAAKEEAPKAE 86
           E++    ESE    + P ++   K K D     + GK  A E    + A  + EE  +  
Sbjct: 154 EQQTYFSESEIVVISRP-DSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKN 212

Query: 87  PEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEAAAAP-------AESAAP 135
             +T    E K  PP   E    +E   P    G    K A A   P       A+   P
Sbjct: 213 ISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPP 272

Query: 136 AAGEEPSKEEGEP-KKTEAPAAPAAQETKSDGAPASDSK-------PGSSEAA------- 180
              E  +K E  P ++T     P+ +ET    A  + ++       P + EA        
Sbjct: 273 LVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAE 332

Query: 181 ---PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
              PS++E+P+        P +   + S E P  +  P A    +V
Sbjct: 333 IQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSV 378


>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 1 [Homo sapiens]
          Length = 559

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 49/208 (23%), Positives = 89/208 (42%), Gaps = 15/208 (7%)

Query: 21  EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
           +K K + G+    + + K S+P         KE +E+P +D+E K+  KE E++ A + +
Sbjct: 173 KKTKPSHGSKDANKESSKTSKPHKVT-----KEHRERPRKDSESKSSSKELEREQAKSSK 227

Query: 81  EAPKAEPEKTEGAAEAKAEPPKAP--EQEQAAPGPAAGGEAPKAAEAAAAP----AESAA 134
           +  +   E      E KA PPKA   E + A         +PK       P    A S  
Sbjct: 228 DTSRKLGEGRL-PKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286

Query: 135 PAAGEEPSKEEGEPKKTEAP---AAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
           PA  + P     + KK+ +    +AP      S  +  SD KP   +++   ++  A +E
Sbjct: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346

Query: 192 APSSTPKAQGPAASAEEPKPVEAPAANS 219
              +    +   +++E+    ++ +A S
Sbjct: 347 PREAKKALEVEESNSEDEASFKSESAQS 374



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 50/220 (22%), Positives = 97/220 (44%), Gaps = 18/220 (8%)

Query: 6   SKKKKGYNVNDEKAKE--KDKKAEGAATEEEGTPKESEPQAAAEPAEA---KEGKEKPDQ 60
           SK  K + V  E  +   KD +++ ++ E E    +S    + +  E    KE K  P +
Sbjct: 189 SKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPK 248

Query: 61  DA--EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE--AKAEPPKAPEQEQ----AAPG 112
            A  E K   KE + ++ + K   P   P     +++  A A+ PK   ++Q    +   
Sbjct: 249 AAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGS 308

Query: 113 PAAGGEAPKAAEAAA----APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
            +A G +P+ + +++     PA+  +   GE+  K E EP++ +         ++ + + 
Sbjct: 309 RSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEK-VKAESEPREAKKALEVEESNSEDEASF 367

Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
            S+S   S   + SS ++ + ++   S   +QGP  S  E
Sbjct: 368 KSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVE 407



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 31/189 (16%), Positives = 77/189 (40%), Gaps = 10/189 (5%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK------ 73
           K+K   ++G+ +    +P+ S   + ++   AK+      +  + ++E +E +K      
Sbjct: 299 KQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEE 358

Query: 74  ----DAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
               D A+ K E+ ++ P  +  ++++ ++    P Q  +     +  E  ++ E+    
Sbjct: 359 SNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDD 418

Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAA 189
           + S   AAG+     +     +++ +  +A  +     P    KP    +  S + +P +
Sbjct: 419 SSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPES 478

Query: 190 TEAPSSTPK 198
              P    K
Sbjct: 479 CSKPEKILK 487



 Score = 36.6 bits (83), Expect = 0.018
 Identities = 31/176 (17%), Positives = 70/176 (39%), Gaps = 10/176 (5%)

Query: 3   GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
           G   +     + +D+K  +      G   + E  P+E++     E + +++      + A
Sbjct: 313 GTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESA 372

Query: 63  EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE--QEQAAPGPAAGGEAP 120
           +          D+++  +  P      ++G   +  E  ++ E  ++ ++ G  A G+  
Sbjct: 373 QSSPSNSSSSSDSSSDSDFEP--SQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTN 430

Query: 121 KAAEA--AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
              ++  + + +ES   A    PS+E   P+K   P +    +     +P S SKP
Sbjct: 431 PGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNS----KVSGRRSPESCSKP 482


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 55/205 (26%), Positives = 82/205 (40%), Gaps = 13/205 (6%)

Query: 20  KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAA 77
           ++++ K+E    EE+ +   SE Q A E     E  +K D +   K E K    E+DA  
Sbjct: 132 RKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKT 191

Query: 78  AKEEAP------KAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
           A +E          EP++     EAKAE  KA  +++A   P    + P   E A   A+
Sbjct: 192 ASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEP----KEPDGKEEAKHGAK 247

Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
             A A  E    EE EP           ++    GA    S P     +P+ +    +T+
Sbjct: 248 EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTD 307

Query: 192 APSSTPKAQGPAA-SAEEPKPVEAP 215
                  A G  + SA E  P + P
Sbjct: 308 GLGPDCVASGQTSPSASESSPSDVP 332



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 62/219 (28%), Positives = 99/219 (45%), Gaps = 45/219 (20%)

Query: 16  DEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAK----------EGKEKPDQDAE 63
           + KA  +++ A+ A+ EE G  KE  +EP+  A   EAK          E K +P ++ +
Sbjct: 179 EPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEP-KEPD 237

Query: 64  GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE-----AKAEP-------PKAPEQEQAAP 111
           GK E K G K+ A AKEEA  AE  +    +E      + EP       P +PE+   +P
Sbjct: 238 GKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESP 297

Query: 112 ------------GP---AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP-KKTEAPA 155
                       GP   A+G  +P A+E++ +    + P +     K+E  P ++  APA
Sbjct: 298 TGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPA 357

Query: 156 APAAQETKSDGAPASDSKPGSSEAAPSS--KETPAATEA 192
            P     ++    A   K G + + P++  + T AA  A
Sbjct: 358 RPRGP--RAQNRKAIVDKFGGAASGPTALFRNTKAAGAA 394



 Score = 58.2 bits (139), Expect = 6e-09
 Identities = 56/228 (24%), Positives = 84/228 (36%), Gaps = 27/228 (11%)

Query: 17  EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDA 75
           +KA+EK+ K E     +     + EP+A  E  +AK   +E+  Q  E   E KE   D 
Sbjct: 155 QKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDE 214

Query: 76  AAAKE-------EAPKAEPEKTEG----------AAEAKAEPPKAPEQEQAAPGPAAGGE 118
            A  E       +  KAEP++ +G           A+AK E   A E E  +P      +
Sbjct: 215 EAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQD 274

Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
             K  E  A    S+     E P+  EG    T+            D   +  + P +SE
Sbjct: 275 VEKEPEGGAGVIPSSPEEWPESPT-GEGHNLSTDG--------LGPDCVASGQTSPSASE 325

Query: 179 AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
           ++PS           S   K + P      P     P A + + +  K
Sbjct: 326 SSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDK 373



 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 57/210 (27%), Positives = 86/210 (40%), Gaps = 16/210 (7%)

Query: 17  EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAA 76
           E  KE  +K E     +E T ++ E ++  EP EA+E KE      + KAEEKE + ++ 
Sbjct: 111 ELKKEDGEKEETTVGSQEMTGRKEETKS--EPKEAEE-KESTLASEKQKAEEKEAKPESG 167

Query: 77  AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPA 136
              ++A   + +K E  A  + E  K   QE+         E  + A    A AES    
Sbjct: 168 ---QKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAV 224

Query: 137 AGEEPSKEEGEPKKTEAPAAPAAQE--TKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
             +E   E  EP   E     A +E   K +   A +++PGS    PS ++     + P 
Sbjct: 225 VEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS----PSEEQEQDVEKEPE 280

Query: 195 STPKAQGPAASAEEPKPVEAPAANSDQTVT 224
                 G   S+ E  P E+P        T
Sbjct: 281 G---GAGVIPSSPEEWP-ESPTGEGHNLST 306



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 58/231 (25%), Positives = 92/231 (39%), Gaps = 29/231 (12%)

Query: 6   SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGK 65
           +K   G  +N+    E  K+ +  A +      + E     E     + +    +DAE +
Sbjct: 52  TKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAE 111

Query: 66  AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE-------QAAPGPAAGGE 118
            ++++GEK      EE      E T    E K+EP +A E+E       Q A    A  E
Sbjct: 112 LKKEDGEK------EETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE 165

Query: 119 APKAAEA---------AAAPAESAAPAAGEEPSKEE---GEPKKTEAPAAPAAQETKS-- 164
           + + A+A         A    E A  A+ EE  + +    EPK+        A+  K+  
Sbjct: 166 SGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVV 225

Query: 165 -DGAPASDSKP-GSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
            D A A   +P G  EA   +KE   A E      +A+  + S E+ + VE
Sbjct: 226 EDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVE 276



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 54/228 (23%), Positives = 91/228 (39%), Gaps = 42/228 (18%)

Query: 18  KAKEKDKKAEGAATEEEGT--PKESEPQAAAEPAEAKE-----------------GKEKP 58
           +A+EK ++ EG  +E+  T  P    P+ +   A A+E                 GK++ 
Sbjct: 14  EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73

Query: 59  DQDAEGKAEEKEGEKDA-----------AAAKEEAPKAEPEKTEGAAE----AKAEPPKA 103
               +G + E +GE +            A  KE+A +AE +K +G  E       E    
Sbjct: 74  APAEDGMSAELQGEANGLDEVKVESQREAGGKEDA-EAELKKEDGEKEETTVGSQEMTGR 132

Query: 104 PEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETK 163
            E+ ++ P  A   E+  A+E   A  + A P +G++    + +  +      P A   +
Sbjct: 133 KEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPE------PKATVEE 186

Query: 164 SDGAPASDSKPGS-SEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
            D   AS  + G   E +   KE     EA + + KA     +  EPK
Sbjct: 187 EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPK 234



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 41/170 (24%), Positives = 62/170 (36%), Gaps = 6/170 (3%)

Query: 54  GKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGP 113
           G+     +A  K E+KEG+              PE + G A A+     A +     P P
Sbjct: 7   GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP-P 65

Query: 114 AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSK 173
              G+  KA       AE    A G +  K E +  +       A  E K +     ++ 
Sbjct: 66  TESGKQEKAPAEDGMSAELQGEANGLDEVKVESQ--REAGGKEDAEAELKKEDGEKEETT 123

Query: 174 PGSSEAAPSSKET---PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
            GS E     +ET   P   E   ST  ++   A  +E KP     A+++
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN 173



 Score = 33.5 bits (75), Expect = 0.15
 Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 15  NDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
           ++E+ ++ +K+ EG A     +P+E       E          PD  A G+         
Sbjct: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQT-------- 319

Query: 75  AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
           + +A E +P   P+    +  +  +  KAPE+  +AP    G   P+A    A   +   
Sbjct: 320 SPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRG---PRAQNRKAIVDKFGG 376

Query: 135 PAAG 138
            A+G
Sbjct: 377 AASG 380


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.287    0.110    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,700,729
Number of Sequences: 37866
Number of extensions: 767228
Number of successful extensions: 24856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1498
Number of HSP's successfully gapped in prelim test: 2083
Number of HSP's that attempted gapping in prelim test: 6242
Number of HSP's gapped (non-prelim): 12066
length of query: 227
length of database: 18,247,518
effective HSP length: 99
effective length of query: 128
effective length of database: 14,498,784
effective search space: 1855844352
effective search space used: 1855844352
T: 11
A: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 45 (21.8 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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