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Search of human proteins with 30794216
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30794216 tripartite motif-containing 56 [Homo sapiens]
(755 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30794216 tripartite motif-containing 56 [Homo sapiens] 1534 0.0
gi|224548923 tripartite motif-containing 45 isoform 2 [Homo sapi... 122 2e-27
gi|224548921 tripartite motif-containing 45 isoform 1 [Homo sapi... 122 2e-27
gi|32454739 tripartite motif-containing 3 [Homo sapiens] 115 2e-25
gi|32454737 tripartite motif-containing 3 [Homo sapiens] 115 2e-25
gi|5032179 tripartite motif-containing 28 protein [Homo sapiens] 102 1e-21
gi|74027251 tripartite motif-containing 33 protein isoform beta ... 97 7e-20
gi|74027249 tripartite motif-containing 33 protein isoform alpha... 97 7e-20
gi|54792146 tripartite motif-containing 47 [Homo sapiens] 95 2e-19
gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens] 94 5e-19
gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens] 94 5e-19
gi|67089160 promyelocytic leukemia protein isoform 11 [Homo sapi... 88 3e-17
gi|67089157 promyelocytic leukemia protein isoform 2 [Homo sapiens] 88 3e-17
gi|15451765 promyelocytic leukemia protein isoform 9 [Homo sapiens] 88 3e-17
gi|67089154 promyelocytic leukemia protein isoform 8 [Homo sapiens] 88 3e-17
gi|4505903 promyelocytic leukemia protein isoform 6 [Homo sapiens] 88 3e-17
gi|15451775 promyelocytic leukemia protein isoform 7 [Homo sapiens] 88 3e-17
gi|15451779 promyelocytic leukemia protein isoform 10 [Homo sapi... 88 3e-17
gi|67089149 promyelocytic leukemia protein isoform 1 [Homo sapiens] 88 3e-17
gi|109637788 promyelocytic leukemia protein isoform 5 [Homo sapi... 88 3e-17
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 82 2e-15
gi|47419909 transcriptional intermediary factor 1 alpha isoform ... 82 2e-15
gi|124487387 ring finger protein 207 [Homo sapiens] 75 3e-13
gi|148833499 midline 1 [Homo sapiens] 74 7e-13
gi|4557753 midline 1 [Homo sapiens] 74 7e-13
gi|15451852 midline 1 [Homo sapiens] 74 7e-13
gi|148596968 tripartite motif-containing 8 [Homo sapiens] 71 3e-12
gi|15208643 ADP-ribosylation factor domain protein 1 isoform gam... 67 6e-11
gi|15208641 ADP-ribosylation factor domain protein 1 isoform bet... 67 6e-11
gi|4502197 ADP-ribosylation factor domain protein 1 isoform alph... 67 6e-11
>gi|30794216 tripartite motif-containing 56 [Homo sapiens]
Length = 755
Score = 1534 bits (3972), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECR 60
MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECR
Sbjct: 1 MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECR 60
Query: 61 ETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARC 120
ETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARC
Sbjct: 61 ETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARC 120
Query: 121 LDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFL 180
LDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFL
Sbjct: 121 LDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFL 180
Query: 181 CQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEA 240
CQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEA
Sbjct: 181 CQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEA 240
Query: 241 LARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQ 300
LARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQ
Sbjct: 241 LARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQ 300
Query: 301 VARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPCLLPQLELHPGLLD 360
VARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPCLLPQLELHPGLLD
Sbjct: 301 VARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPCLLPQLELHPGLLD 360
Query: 361 KNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPK 420
KNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPK
Sbjct: 361 KNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPK 420
Query: 421 EEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPSPALGP 480
EEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPSPALGP
Sbjct: 421 EEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPSPALGP 480
Query: 481 NLDGSGLLPRPIFYCSFPTRMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDY 540
NLDGSGLLPRPIFYCSFPTRMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDY
Sbjct: 481 NLDGSGLLPRPIFYCSFPTRMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDY 540
Query: 541 KGTVPVPEGCSPCSVAALQSAVAFSASARLYLINPNGEVQWRRALSLSQASHAVAALPSG 600
KGTVPVPEGCSPCSVAALQSAVAFSASARLYLINPNGEVQWRRALSLSQASHAVAALPSG
Sbjct: 541 KGTVPVPEGCSPCSVAALQSAVAFSASARLYLINPNGEVQWRRALSLSQASHAVAALPSG 600
Query: 601 DRVAVSVAGHVEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVI 660
DRVAVSVAGHVEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVI
Sbjct: 601 DRVAVSVAGHVEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVI 660
Query: 661 CDGLGQVVGEYKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYH 720
CDGLGQVVGEYKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYH
Sbjct: 661 CDGLGQVVGEYKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYH 720
Query: 721 GLEKPRVTTMVDGRYLVVSLSNGTIHIFRVRSPDS 755
GLEKPRVTTMVDGRYLVVSLSNGTIHIFRVRSPDS
Sbjct: 721 GLEKPRVTTMVDGRYLVVSLSNGTIHIFRVRSPDS 755
>gi|224548923 tripartite motif-containing 45 isoform 2 [Homo
sapiens]
Length = 562
Score = 122 bits (305), Expect = 2e-27
Identities = 91/354 (25%), Positives = 142/354 (40%), Gaps = 46/354 (12%)
Query: 21 CKICLEQLRAPKTLPCLHTYCQDCLAQLAD-------GGR-------------------- 53
C +CL +AP+ LPCLHT C CL QL GG
Sbjct: 29 CPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQS 88
Query: 54 ---VRCPECRETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGT 110
+ CP C V +P GV + + + L R G C LC
Sbjct: 89 QIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQ----GLVCDLC------ 138
Query: 111 STGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCP 170
RC C +LC C HR ++T H +VDL + +R + CP
Sbjct: 139 -NDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKG-----YSRIGKPILCP 192
Query: 171 QHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVEL 230
HP E LR C+ C + +C++C + H +HPC + + + LL G ++ L
Sbjct: 193 VHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEAL 252
Query: 231 EAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARE 290
E A + L+++ V V +EG ++A+ + ++L QL E + +
Sbjct: 253 EEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQL 312
Query: 291 RLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGP 344
+ A+LE R F +L+ G + EIL + + +RLR+L ++ P
Sbjct: 313 QKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRP 366
>gi|224548921 tripartite motif-containing 45 isoform 1 [Homo
sapiens]
Length = 580
Score = 122 bits (305), Expect = 2e-27
Identities = 91/354 (25%), Positives = 142/354 (40%), Gaps = 46/354 (12%)
Query: 21 CKICLEQLRAPKTLPCLHTYCQDCLAQLAD-------GGR-------------------- 53
C +CL +AP+ LPCLHT C CL QL GG
Sbjct: 29 CPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQS 88
Query: 54 ---VRCPECRETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGT 110
+ CP C V +P GV + + + L R G C LC
Sbjct: 89 QIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQ----GLVCDLC------ 138
Query: 111 STGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCP 170
RC C +LC C HR ++T H +VDL + +R + CP
Sbjct: 139 -NDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKG-----YSRIGKPILCP 192
Query: 171 QHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVEL 230
HP E LR C+ C + +C++C + H +HPC + + + LL G ++ L
Sbjct: 193 VHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEAL 252
Query: 231 EAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARE 290
E A + L+++ V V +EG ++A+ + ++L QL E + +
Sbjct: 253 EEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQL 312
Query: 291 RLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGP 344
+ A+LE R F +L+ G + EIL + + +RLR+L ++ P
Sbjct: 313 QKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRP 366
>gi|32454739 tripartite motif-containing 3 [Homo sapiens]
Length = 744
Score = 115 bits (287), Expect = 2e-25
Identities = 183/801 (22%), Positives = 294/801 (36%), Gaps = 133/801 (16%)
Query: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQL--ADGGRVRCPECRETVPVPPE 68
++ + FL C ICL++ + PK LPCLHT+C+ CL A + CP CR+T +P +
Sbjct: 12 VQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQ 71
Query: 69 GVASFKTNFFVNGLLDLVKARACG--DLRAGKPACALC--PLVGGTSTGGPATARCLDCA 124
GV++ + NFF++ L++ ++ G D P + PL G C C
Sbjct: 72 GVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACE 131
Query: 125 DDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQPC 184
+C C G HR +H LR + +
Sbjct: 132 TAMCGECRAGE--------HR-------------------------EHGTVLLRDVVEQH 158
Query: 185 SQLLCRECRLDPHLDHPCLPLAEAVRARRPGLE---GLLAGVDNNLVELEAARRVEKEAL 241
L R+ EAVR R P L L+ G+ L E +A EAL
Sbjct: 159 KAALQRQ--------------LEAVRGRLPQLSAAIALVGGISQQLQERKA------EAL 198
Query: 242 ARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQV 301
A Q+ A E + +AL +KQ ++ L A ++ + +L L ++
Sbjct: 199 A-----------QISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEH 247
Query: 302 ARAAAAFARRVLSLGREAEILSLEGAIAQRLRQL--QGCPWAPGPAPCLLPQLE---LHP 356
++ +FA + L LG E+L + + +RL L Q P P L LE L
Sbjct: 248 IGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRR 307
Query: 357 GLLDKNCHL-LRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQA--- 412
+L+ L + E +G + Q + + ++ + + R G + +A
Sbjct: 308 SVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEIT 367
Query: 413 -GDGAQTP---------KEEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRP----- 457
DG + P E T R EG L P G P R RP
Sbjct: 368 GPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVR-GSPFRVRALRPGDLPP 426
Query: 458 ---NKKKKFKG--------RLKSISREPSP-ALGPNLDGSGLLPRPIFYCSFPTRMPGDK 505
+ K++ K R K++ R S + G + + +F R G+
Sbjct: 427 SPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGE- 485
Query: 506 RSPRITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQSAVAFS 565
+ G+ I+VAD N+ ++ FS G +K V G SP LQ +
Sbjct: 486 -FTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGV-RGRSP---GQLQRPTGVA 540
Query: 566 ASARLYLINPNGEVQWRRALSLS---QASHAVAALPSGDRVAVSVAGHVEV--------- 613
+I + + +W S + L VAV GH+ V
Sbjct: 541 VDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVF 600
Query: 614 -YNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGEYK 672
+ G L RF G R F+ + + V +D+ +SV + G+ + ++
Sbjct: 601 TFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFG 660
Query: 673 GPGLHGCQ---PGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTT 729
G Q P V+VD G I + +++ + D GS L T+ L P+
Sbjct: 661 SHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLA 720
Query: 730 MV-DGRYLVVSLSNGTIHIFR 749
+ DG +V N +R
Sbjct: 721 LTSDGHVVVADAGNHCFKAYR 741
>gi|32454737 tripartite motif-containing 3 [Homo sapiens]
Length = 744
Score = 115 bits (287), Expect = 2e-25
Identities = 183/801 (22%), Positives = 294/801 (36%), Gaps = 133/801 (16%)
Query: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQL--ADGGRVRCPECRETVPVPPE 68
++ + FL C ICL++ + PK LPCLHT+C+ CL A + CP CR+T +P +
Sbjct: 12 VQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQ 71
Query: 69 GVASFKTNFFVNGLLDLVKARACG--DLRAGKPACALC--PLVGGTSTGGPATARCLDCA 124
GV++ + NFF++ L++ ++ G D P + PL G C C
Sbjct: 72 GVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACE 131
Query: 125 DDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQPC 184
+C C G HR +H LR + +
Sbjct: 132 TAMCGECRAGE--------HR-------------------------EHGTVLLRDVVEQH 158
Query: 185 SQLLCRECRLDPHLDHPCLPLAEAVRARRPGLE---GLLAGVDNNLVELEAARRVEKEAL 241
L R+ EAVR R P L L+ G+ L E +A EAL
Sbjct: 159 KAALQRQ--------------LEAVRGRLPQLSAAIALVGGISQQLQERKA------EAL 198
Query: 242 ARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQV 301
A Q+ A E + +AL +KQ ++ L A ++ + +L L ++
Sbjct: 199 A-----------QISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEH 247
Query: 302 ARAAAAFARRVLSLGREAEILSLEGAIAQRLRQL--QGCPWAPGPAPCLLPQLE---LHP 356
++ +FA + L LG E+L + + +RL L Q P P L LE L
Sbjct: 248 IGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRR 307
Query: 357 GLLDKNCHL-LRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQA--- 412
+L+ L + E +G + Q + + ++ + + R G + +A
Sbjct: 308 SVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEIT 367
Query: 413 -GDGAQTP---------KEEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRP----- 457
DG + P E T R EG L P G P R RP
Sbjct: 368 GPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVR-GSPFRVRALRPGDLPP 426
Query: 458 ---NKKKKFKG--------RLKSISREPSP-ALGPNLDGSGLLPRPIFYCSFPTRMPGDK 505
+ K++ K R K++ R S + G + + +F R G+
Sbjct: 427 SPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGE- 485
Query: 506 RSPRITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQSAVAFS 565
+ G+ I+VAD N+ ++ FS G +K V G SP LQ +
Sbjct: 486 -FTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGV-RGRSP---GQLQRPTGVA 540
Query: 566 ASARLYLINPNGEVQWRRALSLS---QASHAVAALPSGDRVAVSVAGHVEV--------- 613
+I + + +W S + L VAV GH+ V
Sbjct: 541 VDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVF 600
Query: 614 -YNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGEYK 672
+ G L RF G R F+ + + V +D+ +SV + G+ + ++
Sbjct: 601 TFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFG 660
Query: 673 GPGLHGCQ---PGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTT 729
G Q P V+VD G I + +++ + D GS L T+ L P+
Sbjct: 661 SHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLA 720
Query: 730 MV-DGRYLVVSLSNGTIHIFR 749
+ DG +V N +R
Sbjct: 721 LTSDGHVVVADAGNHCFKAYR 741
>gi|5032179 tripartite motif-containing 28 protein [Homo sapiens]
Length = 835
Score = 102 bits (255), Expect = 1e-21
Identities = 69/283 (24%), Positives = 120/283 (42%), Gaps = 38/283 (13%)
Query: 21 CKICLEQLRA---PKTLPCLHTYCQDCLAQLA--------------DGGRVRCPECRETV 63
C +C E+LR P+ LPCLH+ C CL A DG V CP C++
Sbjct: 65 CGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQC 124
Query: 64 PVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDC 123
F + N + ++A D + C C PAT+ C++C
Sbjct: 125 ---------FSKDIVENYFMRDSGSKAATDAQDANQCCTSC------EDNAPATSYCVEC 169
Query: 124 ADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQP 183
++ LC+ C + H+ + T H V R+ + + C H E L C+
Sbjct: 170 SEPLCETCVEAHQRVKYTKDHTV------RSTGPAKSRDGERTVYCNVHKHEPLVLFCES 223
Query: 184 CSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALAR 243
C L CR+C+L+ H DH L +AVR +R L L+ + + L+ + + + ++ +
Sbjct: 224 CDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQ 283
Query: 244 LREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEE 286
+ + RV V+ A +++ L + + ++ + E +E
Sbjct: 284 VSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQE 326
>gi|74027251 tripartite motif-containing 33 protein isoform beta
[Homo sapiens]
Length = 1110
Score = 96.7 bits (239), Expect = 7e-20
Identities = 79/348 (22%), Positives = 143/348 (41%), Gaps = 43/348 (12%)
Query: 21 CKICLEQLRA-----PKTLPCLHTYCQDCLAQ----------------LADGGRVRCPEC 59
C +C + L++ PK LPCLH++C CL + + G +RCP C
Sbjct: 125 CAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVC 184
Query: 60 RETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATAR 119
R+ N+FV D +A + D ++ + C C A
Sbjct: 185 RQECRQ-----IDLVDNYFVK---DTSEAPSSSDEKS-EQVCTSC------EDNASAVGF 229
Query: 120 CLDCADDLCQACADGHRCTRQTHTH--RVVDLVGYRAGWYDEEARERQAAQCPQHPGEAL 177
C++C + LC+ C + H+ + T H R + V G A ++ CP H E L
Sbjct: 230 CVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVG-----ASGQRPVFCPVHKQEQL 284
Query: 178 RFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVE 237
+ C+ C +L CR+C+L H +H L EA + ++ +E LLA + + A
Sbjct: 285 KLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQV 344
Query: 238 KEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEG 297
+ + + E RV +++ A ++ + + + +L QL + + ++ ++ G
Sbjct: 345 QNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITG 404
Query: 298 REQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPA 345
+ + F ++ G +L + I +LR + P PA
Sbjct: 405 LSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPA 452
>gi|74027249 tripartite motif-containing 33 protein isoform alpha
[Homo sapiens]
Length = 1127
Score = 96.7 bits (239), Expect = 7e-20
Identities = 79/348 (22%), Positives = 143/348 (41%), Gaps = 43/348 (12%)
Query: 21 CKICLEQLRA-----PKTLPCLHTYCQDCLAQ----------------LADGGRVRCPEC 59
C +C + L++ PK LPCLH++C CL + + G +RCP C
Sbjct: 125 CAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVC 184
Query: 60 RETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATAR 119
R+ N+FV D +A + D ++ + C C A
Sbjct: 185 RQECRQ-----IDLVDNYFVK---DTSEAPSSSDEKS-EQVCTSC------EDNASAVGF 229
Query: 120 CLDCADDLCQACADGHRCTRQTHTH--RVVDLVGYRAGWYDEEARERQAAQCPQHPGEAL 177
C++C + LC+ C + H+ + T H R + V G A ++ CP H E L
Sbjct: 230 CVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVG-----ASGQRPVFCPVHKQEQL 284
Query: 178 RFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVE 237
+ C+ C +L CR+C+L H +H L EA + ++ +E LLA + + A
Sbjct: 285 KLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQV 344
Query: 238 KEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEG 297
+ + + E RV +++ A ++ + + + +L QL + + ++ ++ G
Sbjct: 345 QNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITG 404
Query: 298 REQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPA 345
+ + F ++ G +L + I +LR + P PA
Sbjct: 405 LSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPA 452
>gi|54792146 tripartite motif-containing 47 [Homo sapiens]
Length = 638
Score = 95.1 bits (235), Expect = 2e-19
Identities = 96/366 (26%), Positives = 137/366 (37%), Gaps = 61/366 (16%)
Query: 20 ACKICLEQLRAPKTLPCLHTYCQDCLAQL----------ADGGRVRCPECRETVPVPPEG 69
+C ICLE LR P TLPC H +C CL L GG RCP C+E P+G
Sbjct: 8 SCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPF---PDG 64
Query: 70 VASFKTNFFVNGLLDLVKARACGDLRAGKPA--------------------CALCPLVGG 109
+ + N ++ LL L + G PA CA P G
Sbjct: 65 L-QLRKNHTLSELLQLRQGSGPGSGPGPAPALAPEPSAPSALPSVPEPSAPCAPEPWPAG 123
Query: 110 ----------TSTGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDE 159
PA CL C C A H + HR+V
Sbjct: 124 EEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHRLV-----------P 172
Query: 160 EARERQAAQCPQHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGL 219
R + + CP+H R+ C+ LC C H H +PL + + +
Sbjct: 173 PLRRLEESLCPRHLRPLERY-CRAERVCLCEACAAQEHRGHELVPLEQERALQEAEQSKV 231
Query: 220 LAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRA 279
L+ V++ + EL A + +A ++ A +V AL + +VLG
Sbjct: 232 LSAVEDRMDELGAGIAQSRRTVALIKSAAVAERERVSRLFADAAAALQGFQTQVLG---- 287
Query: 280 HVEAAEEAARERLAELEGREQVARAAAAFARRVLSLGREAEILS-LEGAIAQRLRQLQGC 338
+E E A R R++ R+ + AR+ LS EA+ +S L+ +A RL GC
Sbjct: 288 FIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVPEADSVSFLQELLALRLALEDGC 347
Query: 339 PWAPGP 344
PGP
Sbjct: 348 GPGPGP 353
>gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens]
Length = 744
Score = 94.0 bits (232), Expect = 5e-19
Identities = 79/345 (22%), Positives = 140/345 (40%), Gaps = 71/345 (20%)
Query: 1 MVSHGSS-PS-LLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQL--ADGGRVRC 56
M S G++ PS ++ + FL C ICLE+ + PK LPCLHT+C+ CL A + C
Sbjct: 1 MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSC 60
Query: 57 PECRETVPVPPEGVASFKTNFFVNGLLDLVK------ARACGDLRAGKPACALCPLVGGT 110
P CR+T +P +GVA+ + NFF+ L+D+++ A L A PL
Sbjct: 61 PVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPN 120
Query: 111 STGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCP 170
G C C +C+ C +G
Sbjct: 121 HDGNVMEFYCQSCETAMCRECTEGEHA--------------------------------- 147
Query: 171 QHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVEL 230
+HP L+ + + + L LD AV R P E+
Sbjct: 148 EHPTVPLKDVVEQ------HKASLQVQLD--------AVNKRLP--------------EI 179
Query: 231 EAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARE 290
++A + E + +L Q A + + + + + L +K +L +L + + +
Sbjct: 180 DSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQS 239
Query: 291 RLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQL 335
+L L ++ ++ + F + L+ G E E+L ++ ++++L +L
Sbjct: 240 QLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNEL 284
Score = 49.7 bits (117), Expect = 1e-05
Identities = 40/175 (22%), Positives = 77/175 (44%), Gaps = 11/175 (6%)
Query: 500 RMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQ 559
R PG + P + P G +I++AD N+ + FS +G +K + + P V+ +
Sbjct: 528 RSPGQLQRPTGVAVHPSG--DIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDR 585
Query: 560 SA---VAFSASARLYLINPNGEVQWR---RALSLSQAS--HAVAALPSGDRVAVSVAGH- 610
+ V + + +++ PNG++ R R Q + H A + + + H
Sbjct: 586 NGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHS 645
Query: 611 VEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLG 665
V+V+N EG +F G+ + A + G+ + +DW + + + DG G
Sbjct: 646 VKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSG 700
Score = 37.4 bits (85), Expect = 0.052
Identities = 26/105 (24%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 611 VEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGE 670
V++++ +G +RF G++ L+ + P G + +D+ V I G+ +
Sbjct: 510 VQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTK 569
Query: 671 YKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDF 715
L G P VSVD+ G+I + + V I P G ++ F
Sbjct: 570 IGSGKLMG--PKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRF 612
>gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens]
Length = 771
Score = 94.0 bits (232), Expect = 5e-19
Identities = 79/345 (22%), Positives = 140/345 (40%), Gaps = 71/345 (20%)
Query: 1 MVSHGSS-PS-LLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQL--ADGGRVRC 56
M S G++ PS ++ + FL C ICLE+ + PK LPCLHT+C+ CL A + C
Sbjct: 28 MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSC 87
Query: 57 PECRETVPVPPEGVASFKTNFFVNGLLDLVK------ARACGDLRAGKPACALCPLVGGT 110
P CR+T +P +GVA+ + NFF+ L+D+++ A L A PL
Sbjct: 88 PVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPN 147
Query: 111 STGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCP 170
G C C +C+ C +G
Sbjct: 148 HDGNVMEFYCQSCETAMCRECTEGEHA--------------------------------- 174
Query: 171 QHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVEL 230
+HP L+ + + + L LD AV R P E+
Sbjct: 175 EHPTVPLKDVVEQ------HKASLQVQLD--------AVNKRLP--------------EI 206
Query: 231 EAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARE 290
++A + E + +L Q A + + + + + L +K +L +L + + +
Sbjct: 207 DSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQS 266
Query: 291 RLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQL 335
+L L ++ ++ + F + L+ G E E+L ++ ++++L +L
Sbjct: 267 QLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNEL 311
Score = 49.7 bits (117), Expect = 1e-05
Identities = 40/175 (22%), Positives = 77/175 (44%), Gaps = 11/175 (6%)
Query: 500 RMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQ 559
R PG + P + P G +I++AD N+ + FS +G +K + + P V+ +
Sbjct: 555 RSPGQLQRPTGVAVHPSG--DIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDR 612
Query: 560 SA---VAFSASARLYLINPNGEVQWR---RALSLSQAS--HAVAALPSGDRVAVSVAGH- 610
+ V + + +++ PNG++ R R Q + H A + + + H
Sbjct: 613 NGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHS 672
Query: 611 VEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLG 665
V+V+N EG +F G+ + A + G+ + +DW + + + DG G
Sbjct: 673 VKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSG 727
Score = 37.4 bits (85), Expect = 0.052
Identities = 26/105 (24%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 611 VEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGE 670
V++++ +G +RF G++ L+ + P G + +D+ V I G+ +
Sbjct: 537 VQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTK 596
Query: 671 YKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDF 715
L G P VSVD+ G+I + + V I P G ++ F
Sbjct: 597 IGSGKLMG--PKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRF 639
>gi|67089160 promyelocytic leukemia protein isoform 11 [Homo
sapiens]
Length = 781
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|67089157 promyelocytic leukemia protein isoform 2 [Homo sapiens]
Length = 611
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|15451765 promyelocytic leukemia protein isoform 9 [Homo sapiens]
Length = 829
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|67089154 promyelocytic leukemia protein isoform 8 [Homo sapiens]
Length = 435
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|4505903 promyelocytic leukemia protein isoform 6 [Homo sapiens]
Length = 633
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|15451775 promyelocytic leukemia protein isoform 7 [Homo sapiens]
Length = 423
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|15451779 promyelocytic leukemia protein isoform 10 [Homo
sapiens]
Length = 585
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|67089149 promyelocytic leukemia protein isoform 1 [Homo sapiens]
Length = 882
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|109637788 promyelocytic leukemia protein isoform 5 [Homo
sapiens]
Length = 560
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/324 (24%), Positives = 129/324 (39%), Gaps = 22/324 (6%)
Query: 18 FLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGVASFKTNF 77
FL C+ C + + PK LPCLHT C CL + ++CP C+ P+ + A N
Sbjct: 54 FLRCQQCQAEAKCPKLLPCLHTLCSGCL----EASGMQCPICQAPWPLGADTPA--LDNV 107
Query: 78 FVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRC 137
F L R R A A+C T A C +C LC C + H+
Sbjct: 108 FFESL-----QRRLSVYRQIVDAQAVC-----TRCKESADFWCFECEQLLCAKCFEAHQW 157
Query: 138 TRQTHTHRVVDLVGYRAGWYDEEARERQAAQC--PQHPGEALRFL-CQPCSQLLCRECRL 194
+ + +L + + R+ C P H L + C+ CS+ LC C L
Sbjct: 158 FLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCAL 217
Query: 195 --DPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVG 252
H + C ++ ++ R+ L+ + + A A+ +L A
Sbjct: 218 LDSSHSELKC-DISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE 276
Query: 253 TQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQVARAAAAFARRV 312
+ E V+ + AQ++E+L + A + E RL L+ Q R +A +R+
Sbjct: 277 ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRM 336
Query: 313 LSLGREAEILSLEGAIAQRLRQLQ 336
+ E+L + G + Q L +L+
Sbjct: 337 KCYASDQEVLDMHGFLRQALCRLR 360
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 82.0 bits (201), Expect = 2e-15
Identities = 118/589 (20%), Positives = 211/589 (35%), Gaps = 82/589 (13%)
Query: 21 CKICLE--QLRAPKTLPCLHTYCQDCLAQ-----LADGGRVRCPECRETVPVPPE---GV 70
C +C + Q RAPK LPCLH++CQ CL + + E VP P G
Sbjct: 56 CAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGS 115
Query: 71 ASFKT---------------------NFFVNGLLDLVKARACGDLRAGKPACALCPLVGG 109
+ F T NFFV ++ + + C C
Sbjct: 116 SPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSST----VEKSNQVCTSC----- 166
Query: 110 TSTGGPATARCLDCADDLCQACADGHRCTRQT--HTHRVVDLVGYRAGWYDEEARERQAA 167
A C++C + LC+ C H+ + T HT R + V A ++
Sbjct: 167 -EDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEA----VGVTSQRPV 221
Query: 168 QCPQHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNL 227
CP H E L+ C+ C +L CR+C+L H +H + EA + ++ ++ L+ +
Sbjct: 222 FCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKT 281
Query: 228 VELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEA 287
++ + + + + +V ++ A ++ + + + +L QL + +
Sbjct: 282 KYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMK 341
Query: 288 ARERLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPC 347
++ E+ G + F++ +S G +L + I RLR L P
Sbjct: 342 LMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTN 401
Query: 348 LLPQLELHPGLLDKN-CHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQG 406
Q P +N +L L E+++ Q K P E+
Sbjct: 402 NTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPK----------------QNPVVEQNS 445
Query: 407 GVQPQAGDGAQTPKEEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGR 466
QP +G + + Q + + + + + +P G PN + + +
Sbjct: 446 --QPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQ 503
Query: 467 LKSIS-REPSPAL------GPNLDGSGLLPRPIFYCSFPTRMPGDKRSPRITGLCPFGPR 519
SIS ++P P L P +G L P P R P ++ PR P
Sbjct: 504 QPSISHQQPPPRLINFQNHSPKPNGPVLPPHP-----QQLRYPPNQNIPRQA----IKPN 554
Query: 520 EILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQSAVAFSASA 568
+ +A +A+K++ ++ S S + SA + A
Sbjct: 555 PLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKA 603
>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
[Homo sapiens]
Length = 1016
Score = 81.6 bits (200), Expect = 2e-15
Identities = 84/392 (21%), Positives = 147/392 (37%), Gaps = 50/392 (12%)
Query: 21 CKICLE--QLRAPKTLPCLHTYCQDCLAQ-----LADGGRVRCPECRETVPVPPE---GV 70
C +C + Q RAPK LPCLH++CQ CL + + E VP P G
Sbjct: 56 CAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGS 115
Query: 71 ASFKT---------------------NFFVNGLLDLVKARACGDLRAGKPACALCPLVGG 109
+ F T NFFV ++ + + C C
Sbjct: 116 SPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSST----VEKSNQVCTSC----- 166
Query: 110 TSTGGPATARCLDCADDLCQACADGHRCTRQT--HTHRVVDLVGYRAGWYDEEARERQAA 167
A C++C + LC+ C H+ + T HT R + V A ++
Sbjct: 167 -EDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEA----VGVTSQRPV 221
Query: 168 QCPQHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNL 227
CP H E L+ C+ C +L CR+C+L H +H + EA + ++ ++ L+ +
Sbjct: 222 FCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKT 281
Query: 228 VELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEA 287
++ + + + + +V ++ A ++ + + + +L QL + +
Sbjct: 282 KYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMK 341
Query: 288 ARERLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPC 347
++ E+ G + F++ +S G +L + I RLR L P
Sbjct: 342 LMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTN 401
Query: 348 LLPQLELHPGLLDK---NCHLLRLSFEEQQPQ 376
Q P + N L + +E QPQ
Sbjct: 402 NTIQFHCDPSFWAQNIINLGSLVIEDKESQPQ 433
>gi|124487387 ring finger protein 207 [Homo sapiens]
Length = 634
Score = 74.7 bits (182), Expect = 3e-13
Identities = 90/337 (26%), Positives = 137/337 (40%), Gaps = 38/337 (11%)
Query: 8 PSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECR-ETVPVP 66
PS L+A S L C +C Q P L C H +C CL A GR+ CP C+ +TV
Sbjct: 12 PSSLDAPSIHPLVCPLCHVQYERPCLLDCFHDFCAGCLRGRATDGRLTCPLCQHQTVLKG 71
Query: 67 PEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADD 126
P G+ V+ LL + + + A + CA C L + T C C
Sbjct: 72 PSGLPP------VDRLLQFLVDSSGDGVEAVR--CANCDL-ECSEQDVETTYFCNTCGQP 122
Query: 127 LCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQ-CPQHPGEALRFLCQPCS 185
LC C D R H +V L R R Q C H L F
Sbjct: 123 LCARCRDETHRARMFARHDIVAL----------GQRSRDVPQKCTLHAEPYLLFSTDK-K 171
Query: 186 QLLCRECRLDPHLDH--PCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALAR 243
LLC C D + C+ L A G E L + ++ ++A + +EA+A
Sbjct: 172 LLLCIRCFRDMQKESRAHCVDLESAY---VQGCERL----EQAVLAVKALQTATREAIAL 224
Query: 244 LR---EQAARVGTQVEEAAE---GVLRALLAQKQEVLGQ-LRAHVEAAEEAARERLAELE 296
L+ E+ + E+A G ++ LA+++ +L Q +++ E ++A +E+L+ L
Sbjct: 225 LQAMVEEVRHSAAEEEDAIHALFGSMQDRLAERKALLLQAVQSQYEEKDKAFKEQLSHLA 284
Query: 297 GREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLR 333
+ LSL +AE L L + +RL+
Sbjct: 285 TLLPTLQVHLVICSSFLSLANKAEFLDLGYELMERLQ 321
>gi|148833499 midline 1 [Homo sapiens]
Length = 667
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/296 (23%), Positives = 110/296 (37%), Gaps = 46/296 (15%)
Query: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDC-----LAQLADGGRV------RCPEC 59
+E L S+ L C ICLE P LPC H+ C +C ++ A V +CP C
Sbjct: 1 METLESE-LTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTC 59
Query: 60 RETVPVPPEGVASFKTNFFVNGLLD-LVKARACGD-----------------LRAGKPAC 101
R + + G+ K N + ++D KA G A K C
Sbjct: 60 RHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLC 119
Query: 102 ALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHT-HRVVDLVGYRAGWYDEE 160
C A C+ C C C ++ T HR+++ + D
Sbjct: 120 QFC----DQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIP------DSH 169
Query: 161 ARERQAAQCPQHPGEALRFLCQPCSQLLCRECRL-DPHLDHPCLPLAEAVRARRPGLEGL 219
R C +H E + C QL+C C+L H DH L+E + LE
Sbjct: 170 IR---GLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESN 226
Query: 220 LAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLG 275
L + ELE + + A+R ++ E + +L ++ Q+++++G
Sbjct: 227 LTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECD-LLIEIIQQRRQIIG 281
>gi|4557753 midline 1 [Homo sapiens]
Length = 667
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/296 (23%), Positives = 110/296 (37%), Gaps = 46/296 (15%)
Query: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDC-----LAQLADGGRV------RCPEC 59
+E L S+ L C ICLE P LPC H+ C +C ++ A V +CP C
Sbjct: 1 METLESE-LTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTC 59
Query: 60 RETVPVPPEGVASFKTNFFVNGLLD-LVKARACGD-----------------LRAGKPAC 101
R + + G+ K N + ++D KA G A K C
Sbjct: 60 RHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLC 119
Query: 102 ALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHT-HRVVDLVGYRAGWYDEE 160
C A C+ C C C ++ T HR+++ + D
Sbjct: 120 QFC----DQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIP------DSH 169
Query: 161 ARERQAAQCPQHPGEALRFLCQPCSQLLCRECRL-DPHLDHPCLPLAEAVRARRPGLEGL 219
R C +H E + C QL+C C+L H DH L+E + LE
Sbjct: 170 IR---GLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESN 226
Query: 220 LAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLG 275
L + ELE + + A+R ++ E + +L ++ Q+++++G
Sbjct: 227 LTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECD-LLIEIIQQRRQIIG 281
>gi|15451852 midline 1 [Homo sapiens]
Length = 667
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/296 (23%), Positives = 110/296 (37%), Gaps = 46/296 (15%)
Query: 11 LEALSSDFLACKICLEQLRAPKTLPCLHTYCQDC-----LAQLADGGRV------RCPEC 59
+E L S+ L C ICLE P LPC H+ C +C ++ A V +CP C
Sbjct: 1 METLESE-LTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTC 59
Query: 60 RETVPVPPEGVASFKTNFFVNGLLD-LVKARACGD-----------------LRAGKPAC 101
R + + G+ K N + ++D KA G A K C
Sbjct: 60 RHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLC 119
Query: 102 ALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHT-HRVVDLVGYRAGWYDEE 160
C A C+ C C C ++ T HR+++ + D
Sbjct: 120 QFC----DQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIP------DSH 169
Query: 161 ARERQAAQCPQHPGEALRFLCQPCSQLLCRECRL-DPHLDHPCLPLAEAVRARRPGLEGL 219
R C +H E + C QL+C C+L H DH L+E + LE
Sbjct: 170 IR---GLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESN 226
Query: 220 LAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLG 275
L + ELE + + A+R ++ E + +L ++ Q+++++G
Sbjct: 227 LTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECD-LLIEIIQQRRQIIG 281
>gi|148596968 tripartite motif-containing 8 [Homo sapiens]
Length = 551
Score = 71.2 bits (173), Expect = 3e-12
Identities = 77/282 (27%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 19 LACKICLEQLRAPKTLPCLHTYCQDCL--AQLADGGRVRCPECRETVPVPPEGVASFKTN 76
L C ICL P LPC H +C+ C+ A D G VRCPEC + P + N
Sbjct: 13 LICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKP----GLEKN 68
Query: 77 FFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHR 136
+ +++ A L KP AL + PA CL C CQ+ H
Sbjct: 69 LKLTNIVEKFNA-----LHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTH- 122
Query: 137 CTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQPCSQLLCREC--RL 194
+Q T R LV EA + +A CPQH L + C+ +C+ C
Sbjct: 123 -LQQPSTARGHLLV---------EADDVRAWSCPQHNAYRL-YHCEAEQVAVCQYCCYYS 171
Query: 195 DPHLDHPCL-------PLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQ 247
H H + + + ++ LE +++ L +LE+ +R+ +E + +L+E+
Sbjct: 172 GAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEE 231
Query: 248 AARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAAR 289
V Q E+ + +L L Q EVL + +A +E AA+
Sbjct: 232 ---VRLQYEKLHQ-LLDEDLRQTVEVLDKAQAKF-CSENAAQ 268
>gi|15208643 ADP-ribosylation factor domain protein 1 isoform gamma
[Homo sapiens]
Length = 546
Score = 67.0 bits (162), Expect = 6e-11
Identities = 52/188 (27%), Positives = 78/188 (41%), Gaps = 23/188 (12%)
Query: 19 LACKIC-----LEQLRAPKTLPCLHTYCQDCLAQLADGGR-VRCPECRETVPVPPEGVAS 72
L C +C L+ + P+ L C HT C DCL +L GR +RCP R+ + GV
Sbjct: 29 LECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWG 88
Query: 73 FKTNFFVNGLLDLVKARACGDLRAGKPACALCP---LVGGTSTGGPATARCLDCADDLCQ 129
K NF + LL+ ++ G A + + + + A+ C CA LC
Sbjct: 89 LKKNFALLELLERLQNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCS 148
Query: 130 ACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLC--QPC--S 185
C+ T+ HR V L + + C QH A+ F+C + C S
Sbjct: 149 ECSQVTHSTKTLAKHRRVPLAD----------KPHEKTMCSQHQVHAIEFVCLEEGCQTS 198
Query: 186 QLLCRECR 193
L+C C+
Sbjct: 199 PLMCCVCK 206
>gi|15208641 ADP-ribosylation factor domain protein 1 isoform beta
[Homo sapiens]
Length = 569
Score = 67.0 bits (162), Expect = 6e-11
Identities = 52/188 (27%), Positives = 78/188 (41%), Gaps = 23/188 (12%)
Query: 19 LACKIC-----LEQLRAPKTLPCLHTYCQDCLAQLADGGR-VRCPECRETVPVPPEGVAS 72
L C +C L+ + P+ L C HT C DCL +L GR +RCP R+ + GV
Sbjct: 29 LECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWG 88
Query: 73 FKTNFFVNGLLDLVKARACGDLRAGKPACALCP---LVGGTSTGGPATARCLDCADDLCQ 129
K NF + LL+ ++ G A + + + + A+ C CA LC
Sbjct: 89 LKKNFALLELLERLQNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCS 148
Query: 130 ACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLC--QPC--S 185
C+ T+ HR V L + + C QH A+ F+C + C S
Sbjct: 149 ECSQVTHSTKTLAKHRRVPLAD----------KPHEKTMCSQHQVHAIEFVCLEEGCQTS 198
Query: 186 QLLCRECR 193
L+C C+
Sbjct: 199 PLMCCVCK 206
>gi|4502197 ADP-ribosylation factor domain protein 1 isoform alpha
[Homo sapiens]
Length = 574
Score = 67.0 bits (162), Expect = 6e-11
Identities = 52/188 (27%), Positives = 78/188 (41%), Gaps = 23/188 (12%)
Query: 19 LACKIC-----LEQLRAPKTLPCLHTYCQDCLAQLADGGR-VRCPECRETVPVPPEGVAS 72
L C +C L+ + P+ L C HT C DCL +L GR +RCP R+ + GV
Sbjct: 29 LECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWG 88
Query: 73 FKTNFFVNGLLDLVKARACGDLRAGKPACALCP---LVGGTSTGGPATARCLDCADDLCQ 129
K NF + LL+ ++ G A + + + + A+ C CA LC
Sbjct: 89 LKKNFALLELLERLQNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCS 148
Query: 130 ACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLC--QPC--S 185
C+ T+ HR V L + + C QH A+ F+C + C S
Sbjct: 149 ECSQVTHSTKTLAKHRRVPLAD----------KPHEKTMCSQHQVHAIEFVCLEEGCQTS 198
Query: 186 QLLCRECR 193
L+C C+
Sbjct: 199 PLMCCVCK 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,038,691
Number of Sequences: 37866
Number of extensions: 1787228
Number of successful extensions: 9845
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 433
Number of HSP's that attempted gapping in prelim test: 8036
Number of HSP's gapped (non-prelim): 1810
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.