Search of human proteins with 30348954

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30348954 mindbomb homolog 1 [Homo sapiens]
         (1006 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30348954 mindbomb homolog 1 [Homo sapiens]                        2066   0.0  
gi|21264330 mindbomb homolog 2 [Homo sapiens]                         682   0.0  
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        152   2e-36
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        143   7e-34
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        143   7e-34
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       142   1e-33
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   139   1e-32
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       137   5e-32
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        137   7e-32
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        137   7e-32
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        137   7e-32
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        137   7e-32
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          136   1e-31
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    134   4e-31
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   132   1e-30
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   124   4e-28
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  122   1e-27
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   122   1e-27
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   121   3e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   120   5e-27
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   120   6e-27
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   120   6e-27
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   116   9e-26
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   114   4e-25
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   114   4e-25
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   114   4e-25
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    114   4e-25
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   114   4e-25
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            112   1e-24
gi|50511945 cajalin 2 isoform a [Homo sapiens]                        111   4e-24

>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 2066 bits (5354), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 1    MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY 60
            MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
Sbjct: 1    MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY 60

Query: 61   RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL 120
            RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
Sbjct: 61   RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL 120

Query: 121  RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE 180
            RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
Sbjct: 121  RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE 180

Query: 181  IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN 240
            IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
Sbjct: 181  IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN 240

Query: 241  RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS 300
            RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
Sbjct: 241  RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS 300

Query: 301  GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE 360
            GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
Sbjct: 301  GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE 360

Query: 361  AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK 420
            AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
Sbjct: 361  AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK 420

Query: 421  KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL 480
            KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
Sbjct: 421  KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL 480

Query: 481  KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK 540
            KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
Sbjct: 481  KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK 540

Query: 541  GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 600
            GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL
Sbjct: 541  GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 600

Query: 601  HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD 660
            HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD
Sbjct: 601  HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD 660

Query: 661  IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 720
            IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD
Sbjct: 661  IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 720

Query: 721  MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC 780
            MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC
Sbjct: 721  MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC 780

Query: 781  PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC 840
            PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC
Sbjct: 781  PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC 840

Query: 841  SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC 900
            SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC
Sbjct: 841  SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC 900

Query: 901  RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ 960
            RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ
Sbjct: 901  RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ 960

Query: 961  TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 1006
            TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
Sbjct: 961  TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 1006


>gi|21264330 mindbomb homolog 2 [Homo sapiens]
          Length = 1013

 Score =  682 bits (1759), Expect = 0.0
 Identities = 393/1022 (38%), Positives = 562/1022 (54%), Gaps = 107/1022 (10%)

Query: 14   VGARVVRGPDWKWGKQDGGEGHVGTV------RSFESPEEVVVV-WDNGTAANYRCS--G 64
            VG RVVRG DWKWG+QDGGEG VGTV       S  +P+  VVV WD GT  NYR    G
Sbjct: 69   VGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQG 128

Query: 65   AYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRF 124
            A+DL + D+A  G++H   +CD C++  + G+RWKC  C +YDLCT CY  +KH L H F
Sbjct: 129  AHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAF 188

Query: 125  YRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDW 184
             R  T  S  V L  R+   +I  RGIF GA+VVRG DW+W  QDGG G+ G+V +I+ W
Sbjct: 189  DRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGW 248

Query: 185  SASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLG-----EQNG 239
               +  S A V W +G  N+YRVG +G  DLKCV +A GG +Y+DH P LG     ++  
Sbjct: 249  DVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRV 308

Query: 240  NRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYP 299
            + +    Q GD V   LD ++++ +Q GHGGW   M E +  TGTV  I +  D+ VQ+ 
Sbjct: 309  SADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFN 368

Query: 300  SGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWA 359
               RWTF+P  LTK +                 F VGD+V+V  DL+ +K LQ GHGEW 
Sbjct: 369  HETRWTFHPGALTKHH----------------SFWVGDVVRVIGDLDTVKRLQAGHGEWT 412

Query: 360  EAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV--------SKVASAGSAISNAS 411
            + M P LG+VG+V +++ D +L+V V G  WT++P+ +        + +  A  A  N S
Sbjct: 413  DDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKS 472

Query: 412  GERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAA 471
               LS  L KL   +   +    LV   A G+ A+  DLL+R    V+ +  G TA+Q A
Sbjct: 473  S--LSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVA 530

Query: 472  SQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQ 531
            +  G V++++LLL+    V+  D +G+ A+H+AA G++     VL       +A N  + 
Sbjct: 531  AYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQS 590

Query: 532  TPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR--DDILAVLLEA-GAD 588
            T LH+AV +G L+VV+ L + GC  +L D+  DTPLH AIS       I+ VL E    D
Sbjct: 591  TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNID 650

Query: 589  VTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVA 648
            VT TN+ GF  LHHA+L+G+  A+R +L++  +  +VD KK+DG+TALHLAALNNH EVA
Sbjct: 651  VTATNSQGFTLLHHASLKGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVA 708

Query: 649  ELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
            ++L+ +G  +++++N   Q+ LHLAV++ H  +V LLV AG  ++ +D++GDT LH AL+
Sbjct: 709  QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768

Query: 709  HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG----AEKKSAASIACFLAANGA 764
             H L  L     + D     A  +P    L+  L   G    AE    A++ACFLA  GA
Sbjct: 769  RHQLLPL-----VAD----GAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGA 819

Query: 765  DLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSD 824
            D+S  N +G+SPLDL  +  + KAL  C +     Q G  +        +TL      ++
Sbjct: 820  DVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAP---GPRQTLGTPNTVTN 876

Query: 825  MKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHM 884
            +      GP                            +  EC+VCS+    VLF PC H 
Sbjct: 877  LHVGAAPGP----------------------------EAAECLVCSELALLVLFSPCQHR 908

Query: 885  CACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVN 944
              CE CA  MKKC++C+ VV +++            D ++  S+   P   +        
Sbjct: 909  TVCEECARRMKKCIRCQVVVSKKL----------RPDGSEVASAAPAPGPPRQL------ 952

Query: 945  ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRIL 1004
              V++LQ + + ++E+  CP+C+D    ++F CGHG C  CG  +S CPICR+ I  RI 
Sbjct: 953  --VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQ 1010

Query: 1005 LY 1006
            ++
Sbjct: 1011 IF 1012



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 34/76 (44%), Positives = 44/76 (57%), Gaps = 1/76 (1%)

Query: 150 GIFAGARVVRGVDWQWEDQDGGNGRRGKVTEI-QDWSASSPHSAAYVLWDNGAKNLYRVG 208
           G+  G RVVRGVDW+W  QDGG G  G V E+ +  S S+P     V WD G +  YR G
Sbjct: 66  GVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAG 125

Query: 209 FEGMSDLKCVQDAKGG 224
           ++G  DL    +A+ G
Sbjct: 126 YQGAHDLLLYDNAQIG 141


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  152 bits (383), Expect = 2e-36
 Identities = 97/286 (33%), Positives = 161/286 (56%), Gaps = 10/286 (3%)

Query: 420 KKLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAASQNGHVD 478
           K+  + ++  D N   ++AA  G + K  D +K   D+++  Q  G  A+  AS+ GHV+
Sbjct: 30  KRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQ-NGLNALHLASKEGHVE 88

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           ++  LL++  +V+A  K G+ A+H A+   +  V++VL    A++NA+++   TPL++A 
Sbjct: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFN 598
            + HL+VVK LLD G   SL   +G TPL  A+ +  D ++++LLE      +       
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR----LP 204

Query: 599 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNAN 658
           ALH AA + +  A  +LL         D +   G+T LH+AA   ++ VA LL+++  A 
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNN---ADVESKSGFTPLHIAAHYGNINVATLLLNRA-AA 260

Query: 659 LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704
           +D    N  T LH+A +R +  +V+LL+  GAK+D + +DG TPLH
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLH 306



 Score =  133 bits (335), Expect = 7e-31
 Identities = 92/275 (33%), Positives = 137/275 (49%), Gaps = 5/275 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           +A  G    V+ LL++         +G+T +  +++ GH D+   LL     +    K G
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA   +  V  +L + SA  +A  K   TPLH+A +  + +V   LLD G  P 
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TPLH A  K + DI   LLE GAD       G  ++H AA  G+   + +LL 
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +      V+     G T LHLAA  + V VAE+LV+QG A++D Q     T LH+     
Sbjct: 686 RNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHVDAQTKMGYTPLHVGCHYG 741

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH-HT 711
           + +IV  L++  AK++ + K+G TPLH+A +  HT
Sbjct: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776



 Score =  132 bits (332), Expect = 2e-30
 Identities = 110/395 (27%), Positives = 177/395 (44%), Gaps = 46/395 (11%)

Query: 417 QLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPD--VDVNGQCAGHTAMQAASQN 474
           Q++  L E    G +    +  AA  D  K   LL + D   DV  + +G T +  A+  
Sbjct: 187 QVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK-SGFTPLHIAAHY 245

Query: 475 GHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPL 534
           G++++  LLL +   V+   ++    +H A+      ++++L    A ++A+ +   TPL
Sbjct: 246 GNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305

Query: 535 HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNN 594
           H     GH QVV+ LLD       +   G +PLH A      + + +LL+    V    N
Sbjct: 306 HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTN 365

Query: 595 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 654
           +   ALH AA  G+    +VLL K   P   + K  +G+T LH+A   N ++V ELL+  
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANP---NAKALNGFTPLHIACKKNRIKVMELLLKH 422

Query: 655 G--------------------------------NANLDIQNVNQQTALHLAVERQHTQIV 682
           G                                 A+ +  NV  +TALH+A      ++V
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482

Query: 683 RLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGL 742
           R LV+ GA+++ + KD  TPLH + R      ++QL  +Q     +AA       L +  
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL--LQQGASPNAATTSGYTPLHL-- 538

Query: 743 GTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
               + ++    +A FL  +GA LSI  KKG +PL
Sbjct: 539 ----SAREGHEDVAAFLLDHGASLSITTKKGFTPL 569



 Score =  130 bits (327), Expect = 6e-30
 Identities = 102/365 (27%), Positives = 162/365 (44%), Gaps = 44/365 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           KV +LL +    +     +G T +  A+  GHV+I+  L+         +  G+ A+H A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A   +  V+  L +  A + A+ K  QTPLHI+   G   +V+ LL  G  P+   + G 
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRP-- 622
           TPLH +  +  +D+ A LL+ GA ++IT   GF  LH AA  G      +LL K   P  
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593

Query: 623 ----------------------WIVDE------KKDDGYTALHLAALNNHVEVAELLVHQ 654
                                  ++D+         +GYT LH+AA  N +++A  L+  
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY 653

Query: 655 GNANLDIQNVNQQ--TALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL 712
           G    D   V +Q   ++HLA +  H  +V LL+   A +++ +K G TPLH A +   +
Sbjct: 654 G---ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 710

Query: 713 SQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKK 772
           +    L  +     VDA  +     L +G             I  FL  + A ++ + K 
Sbjct: 711 NVAEVL--VNQGAHVDAQTKMGYTPLHVGC------HYGNIKIVNFLLQHSAKVNAKTKN 762

Query: 773 GQSPL 777
           G +PL
Sbjct: 763 GYTPL 767



 Score =  124 bits (311), Expect = 4e-28
 Identities = 104/346 (30%), Positives = 153/346 (44%), Gaps = 12/346 (3%)

Query: 439 AANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGD 498
           A +G    VE LL R    ++    G + +  A+Q  H++ ++LLL+ NV V+    D  
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368

Query: 499 RAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSL 558
            A+H AA      V +VL    A+ NA+     TPLHIA  K  ++V++ LL  G     
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 559 QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
               G TP+H A      +I++ L+  GA    TN  G  ALH AA  G    +R L+  
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 619 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH 678
             +   V+ K  D  T LH++A     ++ + L+ QG A+ +    +  T LHL+    H
Sbjct: 489 GAQ---VEAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGH 544

Query: 679 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL 738
             +   L+  GA L I  K G TPLH A ++  L     L  +Q     DAA +     L
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL--LQKSASPDAAGKSGLTPL 602

Query: 739 IMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPN 784
            +      A       +A  L   GA      K G +PL +    N
Sbjct: 603 HV------AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 69/235 (29%), Positives = 106/235 (45%), Gaps = 4/235 (1%)

Query: 418 LLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGH 476
           LL+K      +G      +  AA+ D  KV  LL       +     G+T +  A++   
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643

Query: 477 VDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHI 536
           +DI   LL+   D  A  + G  +VH AA      ++ +L   +A++N  NK   TPLH+
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL 703

Query: 537 AVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNG 596
           A  +  + V + L++ G H   Q   G TPLH         I+  LL+  A V     NG
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763

Query: 597 FNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
           +  LH AA +G+   + VLL     P   +E   +G TAL +A    ++ V + L
Sbjct: 764 YTPLHQAAQQGHTHIINVLLQNNASP---NELTVNGNTALGIARRLGYISVVDTL 815



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 16/197 (8%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           ++ G D+ I N NG NALH A+  G+   + V+   L R   VD     G TALH+A+L 
Sbjct: 61  IKNGVDINICNQNGLNALHLASKEGH---VEVVSELLQREANVDAATKKGNTALHIASLA 117

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV ++LV  G AN++ Q+ N  T L++A +  H ++V+ L+  GA   +  +DG TP
Sbjct: 118 GQAEVVKVLVTNG-ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAAN 762
           L  AL+      +  L +    GKV     P+ +          A +K     A  L  N
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRL---PALHI---------AARKDDTKAAALLLQN 224

Query: 763 GADLSIRNKKGQSPLDL 779
             +  + +K G +PL +
Sbjct: 225 DNNADVESKSGFTPLHI 241



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 40/158 (25%), Positives = 63/158 (39%), Gaps = 42/158 (26%)

Query: 627 EKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLV 686
           +KK D   +   AA   H+E A   +  G  +++I N N   ALHLA +  H ++V  L+
Sbjct: 36  KKKSDANASYLRAARAGHLEKALDYIKNG-VDINICNQNGLNALHLASKEGHVEVVSELL 94

Query: 687 RAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG 746
           +  A +D   K G+T LH A           L    +V KV                   
Sbjct: 95  QREANVDAATKKGNTALHIA----------SLAGQAEVVKV------------------- 125

Query: 747 AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPN 784
                       L  NGA+++ +++ G +PL +    N
Sbjct: 126 ------------LVTNGANVNAQSQNGFTPLYMAAQEN 151


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  143 bits (361), Expect = 7e-34
 Identities = 99/310 (31%), Positives = 174/310 (56%), Gaps = 13/310 (4%)

Query: 405 SAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCA 463
           +A  + SGE+ +   ++    ++S D N   ++AA  G++ KV + LK   +D+N     
Sbjct: 6   AAQKSDSGEKFNGSSQRRKRPKKS-DSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQN 63

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G  A+  A++ GHV +++ LL +   V++  K G+ A+H A+   +  V++VL +  A++
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           NA+++   TPL++A  + H+ VVK LL+ G + S    +G TPL  A+ +  +  +A+LL
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLL-----SKLPRPWIVDEKKDDGYTALHL 638
           E      +       ALH AA + +  +  +LL     + +    +V+   + G+T LH+
Sbjct: 184 ENDTKGKVR----LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   +V VA LL+++G A +D    N  T LH+A +R +T +V+LL+  G ++D + +D
Sbjct: 240 AAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 699 GDTPLHEALR 708
           G TPLH A R
Sbjct: 299 GLTPLHCAAR 308



 Score =  140 bits (354), Expect = 5e-33
 Identities = 103/315 (32%), Positives = 155/315 (49%), Gaps = 12/315 (3%)

Query: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
           +G T +  A+  GH++I+ LLL+     +  +  G+ A+H AA   +  V+  L R  A 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582
           ++AR +  QTPLHIA   G  ++V+ LL    HP    + G TPLH +  + + D+ +VL
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           LEAGA  ++    GF  LH AA  G+    ++LL    R    D    +G T LH+AA  
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKNGLTPLHVAAHY 606

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
           ++ +VA LL+ +G A+      N  T LH+A ++   QI   L+  GA+ +I  K G TP
Sbjct: 607 DNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAAN 762
           LH A +      +  L D        A    S  + +  L     E K   ++A  L  +
Sbjct: 666 LHLASQEGHTDMVTLLLDK------GANIHMSTKSGLTSLHLAAQEDK--VNVADILTKH 717

Query: 763 GADLSIRNKKGQSPL 777
           GAD     K G +PL
Sbjct: 718 GADQDAHTKLGYTPL 732



 Score =  124 bits (312), Expect = 3e-28
 Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 6/272 (2%)

Query: 438 AAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           A+  G+   V+ LL R   +D   +  G T +  A+++GH  +++LLL++   + A  K+
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H AA GD    ++ L +  A ++       T LH+A + GH +V K LLD   +P
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
           + +   G TPLH A  K R  ++ +L++ GA +     +G   +H AA  G+ + + +LL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
                P + + +   G TALH+AA    VEV   L+  G A +D +   +QT LH+A   
Sbjct: 452 QNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNG-ALVDARAREEQTPLHIASRL 507

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
             T+IV+LL++  A  D    +G TPLH + R
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 539



 Score =  123 bits (308), Expect = 1e-27
 Identities = 78/245 (31%), Positives = 128/245 (52%), Gaps = 4/245 (1%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A++ G +D+ KLLL++    ++  K+G   +H AA  D   V  +L    A  
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           +A  K   TPLHIA  K  +Q+  TLL++G   ++   +G TPLH A  +   D++ +LL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           + GA++ ++  +G  +LH AA     +   +L          D     GYT L +A    
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYG 739

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
           +V++   L+ QG AN++ +  N  T LH A ++ HT I+ +L++ GAK +    +G+T L
Sbjct: 740 NVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798

Query: 704 HEALR 708
             A R
Sbjct: 799 AIAKR 803



 Score =  122 bits (305), Expect = 2e-27
 Identities = 110/367 (29%), Positives = 166/367 (45%), Gaps = 29/367 (7%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA +G    VE LL+R    +     G + +  A+Q  HV+ +K LL+    V+    D 
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
             A+H AA      V ++L    A+ NAR     TPLHIA  K  ++V++ L+ +G    
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TP+H A      +I+ +LL+ GA   +TN  G  ALH AA  G    +R LL 
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 +VD +  +  T LH+A+     E+ +LL+ Q  A+ D    N  T LH++    
Sbjct: 486 NGA---LVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREG 541

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ----DVGK------- 726
              +  +L+ AGA   +  K G TPLH A ++ +L   + L   +      GK       
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 727 VDAAWEPSKNTLIM--------GLGTQG------AEKKSAASIACFLAANGADLSIRNKK 772
           V A ++  K  L++             G      A KK+   IA  L   GA+ +I  K+
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 773 GQSPLDL 779
           G +PL L
Sbjct: 662 GVTPLHL 668



 Score =  120 bits (302), Expect = 5e-27
 Identities = 99/318 (31%), Positives = 155/318 (48%), Gaps = 26/318 (8%)

Query: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF-GDEGAVIEVLHRGSADLNARNKR 529
           A++ G++D +   LK  +D+   +++G  A+H AA  G  G V E+L RGS+ +++  K+
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKK 96

Query: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
             T LHIA   G  +VVK L+  G + + Q   G TPL+ A  +   D++  LLE GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 590 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE 649
           +    +GF  L  A  +G+  A+ +LL         D K      ALH+AA  +  + A 
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAA 209

Query: 650 LLVHQGNANLDIQN---VNQQTA-----LHLAVERQHTQIVRLLVRAGAKLDIQDKDGDT 701
           LL+ Q + N D+Q+   VN+ T      LH+A    +  +  LL+  GA +D   ++G T
Sbjct: 210 LLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAA 761
           PLH A +    + ++ L D    G++DA        L        A +     +   L  
Sbjct: 269 PLHVASKRGNTNMVKLLLDRG--GQIDAKTRDGLTPL------HCAARSGHDQVVELLLE 320

Query: 762 NGADLSIRNKKGQSPLDL 779
            GA L  R K G SPL +
Sbjct: 321 RGAPLLARTKNGLSPLHM 338



 Score =  120 bits (301), Expect = 6e-27
 Identities = 107/403 (26%), Positives = 175/403 (43%), Gaps = 52/403 (12%)

Query: 416 SQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC---------AGHT 466
           +Q +  L E    G +    +  AA  D  K   LL + D + + Q          +G T
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
            +  A+  G+V++  LLL +   V+   ++G   +H A+      ++++L      ++A+
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLH A   GH QVV+ LL+ G     +   G +PLH A      + +  LL+  
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A V     +   ALH AA  G+    ++LL K   P   + +  +G+T LH+A   N ++
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIK 412

Query: 647 VAELLVH--------------------------------QGNANLDIQNVNQQTALHLAV 674
           V ELLV                                 Q  A+ D+ N+  +TALH+A 
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472

Query: 675 ERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPS 734
                ++VR L+R GA +D + ++  TPLH A R      ++ L  +Q +   DAA    
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL--LQHMAHPDAATTNG 530

Query: 735 KNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
              L +      + ++    +A  L   GA  S+  KKG +PL
Sbjct: 531 YTPLHI------SAREGQVDVASVLLEAGAAHSLATKKGFTPL 567



 Score =  107 bits (267), Expect = 6e-23
 Identities = 85/281 (30%), Positives = 124/281 (44%), Gaps = 4/281 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA  G V  V  LL+   +         T +  AS+ G  +I++LLL+     +A   +G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H +A   +  V  VL    A  +   K+  TPLH+A   G L V K LL       
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TPLH A       +  +LLE GA    T  NG+  LH AA +        LL+
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 IV ++   G T LHLA+   H ++  LL+ +G AN+ +   +  T+LHLA +  
Sbjct: 651 YGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQED 706

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
              +  +L + GA  D   K G TPL  A  +  +  +  L
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 72/243 (29%), Positives = 111/243 (45%), Gaps = 6/243 (2%)

Query: 443 DVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVH 502
           DVAK+  L +R   D  G+  G T +  A+   +  +  LLL++     A  K+G   +H
Sbjct: 577 DVAKLL-LQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 503 HAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562
            AA  ++  +   L    A+ N   K+  TPLH+A  +GH  +V  LLD G +  +    
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694

Query: 563 GDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRP 622
           G T LH A  + + ++  +L + GAD       G+  L  A   GN   +  LL +    
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN- 753

Query: 623 WIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV 682
             V+ K  +GYT LH AA   H  +  +L+  G A  +    N  TAL +A    +  +V
Sbjct: 754 --VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVV 810

Query: 683 RLL 685
             L
Sbjct: 811 DTL 813



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 40/171 (23%), Positives = 73/171 (42%), Gaps = 42/171 (24%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G  ALHLAA   HV + + L+ +G++ +D       TALH+A      ++V++LV+ GA
Sbjct: 63  NGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q ++G TPL+ A + + +  ++                                  
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVK---------------------------------- 147

Query: 751 SAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQV 801
                  +L  NGA+ S   + G +PL +       +A+A   +    G+V
Sbjct: 148 -------YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  143 bits (361), Expect = 7e-34
 Identities = 99/310 (31%), Positives = 174/310 (56%), Gaps = 13/310 (4%)

Query: 405 SAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCA 463
           +A  + SGE+ +   ++    ++S D N   ++AA  G++ KV + LK   +D+N     
Sbjct: 6   AAQKSDSGEKFNGSSQRRKRPKKS-DSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQN 63

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G  A+  A++ GHV +++ LL +   V++  K G+ A+H A+   +  V++VL +  A++
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           NA+++   TPL++A  + H+ VVK LL+ G + S    +G TPL  A+ +  +  +A+LL
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLL-----SKLPRPWIVDEKKDDGYTALHL 638
           E      +       ALH AA + +  +  +LL     + +    +V+   + G+T LH+
Sbjct: 184 ENDTKGKVR----LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   +V VA LL+++G A +D    N  T LH+A +R +T +V+LL+  G ++D + +D
Sbjct: 240 AAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 699 GDTPLHEALR 708
           G TPLH A R
Sbjct: 299 GLTPLHCAAR 308



 Score =  140 bits (354), Expect = 5e-33
 Identities = 103/315 (32%), Positives = 155/315 (49%), Gaps = 12/315 (3%)

Query: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
           +G T +  A+  GH++I+ LLL+     +  +  G+ A+H AA   +  V+  L R  A 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582
           ++AR +  QTPLHIA   G  ++V+ LL    HP    + G TPLH +  + + D+ +VL
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           LEAGA  ++    GF  LH AA  G+    ++LL    R    D    +G T LH+AA  
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKNGLTPLHVAAHY 606

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
           ++ +VA LL+ +G A+      N  T LH+A ++   QI   L+  GA+ +I  K G TP
Sbjct: 607 DNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAAN 762
           LH A +      +  L D        A    S  + +  L     E K   ++A  L  +
Sbjct: 666 LHLASQEGHTDMVTLLLDK------GANIHMSTKSGLTSLHLAAQEDK--VNVADILTKH 717

Query: 763 GADLSIRNKKGQSPL 777
           GAD     K G +PL
Sbjct: 718 GADQDAHTKLGYTPL 732



 Score =  124 bits (312), Expect = 3e-28
 Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 6/272 (2%)

Query: 438 AAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           A+  G+   V+ LL R   +D   +  G T +  A+++GH  +++LLL++   + A  K+
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H AA GD    ++ L +  A ++       T LH+A + GH +V K LLD   +P
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
           + +   G TPLH A  K R  ++ +L++ GA +     +G   +H AA  G+ + + +LL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
                P + + +   G TALH+AA    VEV   L+  G A +D +   +QT LH+A   
Sbjct: 452 QNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNG-ALVDARAREEQTPLHIASRL 507

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
             T+IV+LL++  A  D    +G TPLH + R
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 539



 Score =  123 bits (308), Expect = 1e-27
 Identities = 78/245 (31%), Positives = 128/245 (52%), Gaps = 4/245 (1%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A++ G +D+ KLLL++    ++  K+G   +H AA  D   V  +L    A  
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           +A  K   TPLHIA  K  +Q+  TLL++G   ++   +G TPLH A  +   D++ +LL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           + GA++ ++  +G  +LH AA     +   +L          D     GYT L +A    
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYG 739

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
           +V++   L+ QG AN++ +  N  T LH A ++ HT I+ +L++ GAK +    +G+T L
Sbjct: 740 NVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798

Query: 704 HEALR 708
             A R
Sbjct: 799 AIAKR 803



 Score =  122 bits (305), Expect = 2e-27
 Identities = 110/367 (29%), Positives = 166/367 (45%), Gaps = 29/367 (7%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA +G    VE LL+R    +     G + +  A+Q  HV+ +K LL+    V+    D 
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
             A+H AA      V ++L    A+ NAR     TPLHIA  K  ++V++ L+ +G    
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TP+H A      +I+ +LL+ GA   +TN  G  ALH AA  G    +R LL 
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 +VD +  +  T LH+A+     E+ +LL+ Q  A+ D    N  T LH++    
Sbjct: 486 NGA---LVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREG 541

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ----DVGK------- 726
              +  +L+ AGA   +  K G TPLH A ++ +L   + L   +      GK       
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 727 VDAAWEPSKNTLIM--------GLGTQG------AEKKSAASIACFLAANGADLSIRNKK 772
           V A ++  K  L++             G      A KK+   IA  L   GA+ +I  K+
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 773 GQSPLDL 779
           G +PL L
Sbjct: 662 GVTPLHL 668



 Score =  120 bits (302), Expect = 5e-27
 Identities = 99/318 (31%), Positives = 155/318 (48%), Gaps = 26/318 (8%)

Query: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF-GDEGAVIEVLHRGSADLNARNKR 529
           A++ G++D +   LK  +D+   +++G  A+H AA  G  G V E+L RGS+ +++  K+
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKK 96

Query: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
             T LHIA   G  +VVK L+  G + + Q   G TPL+ A  +   D++  LLE GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 590 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE 649
           +    +GF  L  A  +G+  A+ +LL         D K      ALH+AA  +  + A 
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAA 209

Query: 650 LLVHQGNANLDIQN---VNQQTA-----LHLAVERQHTQIVRLLVRAGAKLDIQDKDGDT 701
           LL+ Q + N D+Q+   VN+ T      LH+A    +  +  LL+  GA +D   ++G T
Sbjct: 210 LLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAA 761
           PLH A +    + ++ L D    G++DA        L        A +     +   L  
Sbjct: 269 PLHVASKRGNTNMVKLLLDRG--GQIDAKTRDGLTPL------HCAARSGHDQVVELLLE 320

Query: 762 NGADLSIRNKKGQSPLDL 779
            GA L  R K G SPL +
Sbjct: 321 RGAPLLARTKNGLSPLHM 338



 Score =  120 bits (301), Expect = 6e-27
 Identities = 107/403 (26%), Positives = 175/403 (43%), Gaps = 52/403 (12%)

Query: 416 SQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC---------AGHT 466
           +Q +  L E    G +    +  AA  D  K   LL + D + + Q          +G T
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
            +  A+  G+V++  LLL +   V+   ++G   +H A+      ++++L      ++A+
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLH A   GH QVV+ LL+ G     +   G +PLH A      + +  LL+  
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A V     +   ALH AA  G+    ++LL K   P   + +  +G+T LH+A   N ++
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIK 412

Query: 647 VAELLVH--------------------------------QGNANLDIQNVNQQTALHLAV 674
           V ELLV                                 Q  A+ D+ N+  +TALH+A 
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472

Query: 675 ERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPS 734
                ++VR L+R GA +D + ++  TPLH A R      ++ L  +Q +   DAA    
Sbjct: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL--LQHMAHPDAATTNG 530

Query: 735 KNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
              L +      + ++    +A  L   GA  S+  KKG +PL
Sbjct: 531 YTPLHI------SAREGQVDVASVLLEAGAAHSLATKKGFTPL 567



 Score =  107 bits (267), Expect = 6e-23
 Identities = 85/281 (30%), Positives = 124/281 (44%), Gaps = 4/281 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA  G V  V  LL+   +         T +  AS+ G  +I++LLL+     +A   +G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H +A   +  V  VL    A  +   K+  TPLH+A   G L V K LL       
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TPLH A       +  +LLE GA    T  NG+  LH AA +        LL+
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 IV ++   G T LHLA+   H ++  LL+ +G AN+ +   +  T+LHLA +  
Sbjct: 651 YGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQED 706

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
              +  +L + GA  D   K G TPL  A  +  +  +  L
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 72/243 (29%), Positives = 111/243 (45%), Gaps = 6/243 (2%)

Query: 443 DVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVH 502
           DVAK+  L +R   D  G+  G T +  A+   +  +  LLL++     A  K+G   +H
Sbjct: 577 DVAKLL-LQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 503 HAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562
            AA  ++  +   L    A+ N   K+  TPLH+A  +GH  +V  LLD G +  +    
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694

Query: 563 GDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRP 622
           G T LH A  + + ++  +L + GAD       G+  L  A   GN   +  LL +    
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN- 753

Query: 623 WIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV 682
             V+ K  +GYT LH AA   H  +  +L+  G A  +    N  TAL +A    +  +V
Sbjct: 754 --VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVV 810

Query: 683 RLL 685
             L
Sbjct: 811 DTL 813



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 40/171 (23%), Positives = 73/171 (42%), Gaps = 42/171 (24%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G  ALHLAA   HV + + L+ +G++ +D       TALH+A      ++V++LV+ GA
Sbjct: 63  NGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGA 121

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q ++G TPL+ A + + +  ++                                  
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVK---------------------------------- 147

Query: 751 SAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQV 801
                  +L  NGA+ S   + G +PL +       +A+A   +    G+V
Sbjct: 148 -------YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  142 bits (359), Expect = 1e-33
 Identities = 94/288 (32%), Positives = 162/288 (56%), Gaps = 12/288 (4%)

Query: 427 ESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLK 485
           +  D N   ++AA  G++ KV + LK   +D+N     G  A+  A++ GHV +++ LL 
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 486 QNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQV 545
           +   V++  K G+ A+H A+   +  V++VL +  A++NA+++   TPL++A  + H+ V
Sbjct: 65  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124

Query: 546 VKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAAL 605
           VK LL+ G + S    +G TPL  A+ +  +  +A+LLE      +       ALH AA 
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR----LPALHIAAR 180

Query: 606 RGNPSAMRVLL-----SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD 660
           + +  +  +LL     + +    +V+   + G+T LH+AA   +V VA LL+++G A +D
Sbjct: 181 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG-AAVD 239

Query: 661 IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
               N  T LH+A +R +T +V+LL+  G ++D + +DG TPLH A R
Sbjct: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287



 Score =  140 bits (354), Expect = 5e-33
 Identities = 103/315 (32%), Positives = 155/315 (49%), Gaps = 12/315 (3%)

Query: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
           +G T +  A+  GH++I+ LLL+     +  +  G+ A+H AA   +  V+  L R  A 
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468

Query: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582
           ++AR +  QTPLHIA   G  ++V+ LL    HP    + G TPLH +  + + D+ +VL
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           LEAGA  ++    GF  LH AA  G+    ++LL    R    D    +G T LH+AA  
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKNGLTPLHVAAHY 585

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
           ++ +VA LL+ +G A+      N  T LH+A ++   QI   L+  GA+ +I  K G TP
Sbjct: 586 DNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAAN 762
           LH A +      +  L D        A    S  + +  L     E K   ++A  L  +
Sbjct: 645 LHLASQEGHTDMVTLLLDK------GANIHMSTKSGLTSLHLAAQEDK--VNVADILTKH 696

Query: 763 GADLSIRNKKGQSPL 777
           GAD     K G +PL
Sbjct: 697 GADQDAHTKLGYTPL 711



 Score =  124 bits (312), Expect = 3e-28
 Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 6/272 (2%)

Query: 438 AAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           A+  G+   V+ LL R   +D   +  G T +  A+++GH  +++LLL++   + A  K+
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H AA GD    ++ L +  A ++       T LH+A + GH +V K LLD   +P
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
           + +   G TPLH A  K R  ++ +L++ GA +     +G   +H AA  G+ + + +LL
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 430

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
                P + + +   G TALH+AA    VEV   L+  G A +D +   +QT LH+A   
Sbjct: 431 QNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNG-ALVDARAREEQTPLHIASRL 486

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
             T+IV+LL++  A  D    +G TPLH + R
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 518



 Score =  123 bits (308), Expect = 1e-27
 Identities = 78/245 (31%), Positives = 128/245 (52%), Gaps = 4/245 (1%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A++ G +D+ KLLL++    ++  K+G   +H AA  D   V  +L    A  
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           +A  K   TPLHIA  K  +Q+  TLL++G   ++   +G TPLH A  +   D++ +LL
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           + GA++ ++  +G  +LH AA     +   +L          D     GYT L +A    
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYG 718

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
           +V++   L+ QG AN++ +  N  T LH A ++ HT I+ +L++ GAK +    +G+T L
Sbjct: 719 NVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777

Query: 704 HEALR 708
             A R
Sbjct: 778 AIAKR 782



 Score =  122 bits (305), Expect = 2e-27
 Identities = 110/367 (29%), Positives = 166/367 (45%), Gaps = 29/367 (7%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA +G    VE LL+R    +     G + +  A+Q  HV+ +K LL+    V+    D 
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
             A+H AA      V ++L    A+ NAR     TPLHIA  K  ++V++ L+ +G    
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TP+H A      +I+ +LL+ GA   +TN  G  ALH AA  G    +R LL 
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 +VD +  +  T LH+A+     E+ +LL+ Q  A+ D    N  T LH++    
Sbjct: 465 NGA---LVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREG 520

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ----DVGK------- 726
              +  +L+ AGA   +  K G TPLH A ++ +L   + L   +      GK       
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580

Query: 727 VDAAWEPSKNTLIM--------GLGTQG------AEKKSAASIACFLAANGADLSIRNKK 772
           V A ++  K  L++             G      A KK+   IA  L   GA+ +I  K+
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640

Query: 773 GQSPLDL 779
           G +PL L
Sbjct: 641 GVTPLHL 647



 Score =  120 bits (302), Expect = 5e-27
 Identities = 99/318 (31%), Positives = 155/318 (48%), Gaps = 26/318 (8%)

Query: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF-GDEGAVIEVLHRGSADLNARNKR 529
           A++ G++D +   LK  +D+   +++G  A+H AA  G  G V E+L RGS+ +++  K+
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS-VDSATKK 75

Query: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
             T LHIA   G  +VVK L+  G + + Q   G TPL+ A  +   D++  LLE GA+ 
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 590 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE 649
           +    +GF  L  A  +G+  A+ +LL         D K      ALH+AA  +  + A 
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAA 188

Query: 650 LLVHQGNANLDIQN---VNQQTA-----LHLAVERQHTQIVRLLVRAGAKLDIQDKDGDT 701
           LL+ Q + N D+Q+   VN+ T      LH+A    +  +  LL+  GA +D   ++G T
Sbjct: 189 LLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 247

Query: 702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAA 761
           PLH A +    + ++ L D    G++DA        L        A +     +   L  
Sbjct: 248 PLHVASKRGNTNMVKLLLDRG--GQIDAKTRDGLTPL------HCAARSGHDQVVELLLE 299

Query: 762 NGADLSIRNKKGQSPLDL 779
            GA L  R K G SPL +
Sbjct: 300 RGAPLLARTKNGLSPLHM 317



 Score =  120 bits (301), Expect = 6e-27
 Identities = 107/403 (26%), Positives = 175/403 (43%), Gaps = 52/403 (12%)

Query: 416 SQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC---------AGHT 466
           +Q +  L E    G +    +  AA  D  K   LL + D + + Q          +G T
Sbjct: 155 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 214

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
            +  A+  G+V++  LLL +   V+   ++G   +H A+      ++++L      ++A+
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLH A   GH QVV+ LL+ G     +   G +PLH A      + +  LL+  
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A V     +   ALH AA  G+    ++LL K   P   + +  +G+T LH+A   N ++
Sbjct: 335 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIK 391

Query: 647 VAELLVH--------------------------------QGNANLDIQNVNQQTALHLAV 674
           V ELLV                                 Q  A+ D+ N+  +TALH+A 
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 451

Query: 675 ERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPS 734
                ++VR L+R GA +D + ++  TPLH A R      ++ L  +Q +   DAA    
Sbjct: 452 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL--LQHMAHPDAATTNG 509

Query: 735 KNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
              L +      + ++    +A  L   GA  S+  KKG +PL
Sbjct: 510 YTPLHI------SAREGQVDVASVLLEAGAAHSLATKKGFTPL 546



 Score =  107 bits (267), Expect = 6e-23
 Identities = 85/281 (30%), Positives = 124/281 (44%), Gaps = 4/281 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA  G V  V  LL+   +         T +  AS+ G  +I++LLL+     +A   +G
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H +A   +  V  VL    A  +   K+  TPLH+A   G L V K LL       
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
                G TPLH A       +  +LLE GA    T  NG+  LH AA +        LL+
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
                 IV ++   G T LHLA+   H ++  LL+ +G AN+ +   +  T+LHLA +  
Sbjct: 630 YGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQED 685

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
              +  +L + GA  D   K G TPL  A  +  +  +  L
Sbjct: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 72/243 (29%), Positives = 111/243 (45%), Gaps = 6/243 (2%)

Query: 443 DVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVH 502
           DVAK+  L +R   D  G+  G T +  A+   +  +  LLL++     A  K+G   +H
Sbjct: 556 DVAKLL-LQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 613

Query: 503 HAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562
            AA  ++  +   L    A+ N   K+  TPLH+A  +GH  +V  LLD G +  +    
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673

Query: 563 GDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRP 622
           G T LH A  + + ++  +L + GAD       G+  L  A   GN   +  LL +    
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN- 732

Query: 623 WIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV 682
             V+ K  +GYT LH AA   H  +  +L+  G A  +    N  TAL +A    +  +V
Sbjct: 733 --VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVV 789

Query: 683 RLL 685
             L
Sbjct: 790 DTL 792



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 58/170 (34%), Positives = 84/170 (49%), Gaps = 4/170 (2%)

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
           LQ S+ +     A      D +   L+ G D+   N NG NALH AA  G+   ++ LL 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
              R   VD     G TALH+A+L    EV ++LV +G AN++ Q+ N  T L++A +  
Sbjct: 65  ---RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQEN 120

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKV 727
           H  +V+ L+  GA      +DG TPL  AL+      +  L +    GKV
Sbjct: 121 HIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 170



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 44/175 (25%), Positives = 79/175 (45%), Gaps = 10/175 (5%)

Query: 627 EKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLV 686
           +K D   + L  A   N  +V E L  +G  +++  N N   ALHLA +  H  +V+ L+
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63

Query: 687 RAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG 746
             G+ +D   K G+T LH A        ++ L  +++   ++A  +     L M      
Sbjct: 64  GRGSSVDSATKKGNTALHIASLAGQAEVVKVL--VKEGANINAQSQNGFTPLYM------ 115

Query: 747 AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQV 801
           A +++   +  +L  NGA+ S   + G +PL +       +A+A   +    G+V
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 170


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  139 bits (350), Expect = 1e-32
 Identities = 121/406 (29%), Positives = 192/406 (47%), Gaps = 34/406 (8%)

Query: 406 AISNASGERLSQLLKKLFETQESGDLNEE-------LVKAAANGDVAKVEDLLKR-PDVD 457
           A+++ S E +  LLK       S D+N         L  AAAN  V   E L+    +V+
Sbjct: 81  AVASCSEEAVQVLLK------HSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134

Query: 458 VNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH 517
           V+ + AG TA+  A+ +GH +++KLLL +  ++ A DK   RA+H AA+     V+++L 
Sbjct: 135 VSDR-AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 518 RGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDD 577
              A++  ++K+  TPLH A + G + VVK LLD G   +  ++ G+TPLH A    +D 
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253

Query: 578 ILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALH 637
           ++  L++ GA V   N  GF  LH AA   + +    LL  +     V+ K  DG T LH
Sbjct: 254 VVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL--VGNGADVNMKSKDGKTPLH 311

Query: 638 LAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 697
           + AL+     ++ ++  G A +D ++ N  T LH+A    H  ++  L+ +GA    +  
Sbjct: 312 MTALHGRFSRSQTIIQSG-AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370

Query: 698 DGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIAC 757
            G  PLH A         R+L  +     +D   +  +  L        A          
Sbjct: 371 HGMFPLHLAALSGFSDCCRKL--LSSGFDIDTPDDFGRTCL------HAAAAGGNLECLN 422

Query: 758 FLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGS 803
            L   GAD + ++K G+SPL          A A C+ + +   VGS
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHY--------AAANCNYQCLFALVGS 460



 Score =  118 bits (296), Expect = 2e-26
 Identities = 97/334 (29%), Positives = 154/334 (46%), Gaps = 16/334 (4%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  +  NGH D +  LL +  +V+A+DK G  A+H  A       ++ L +  A  
Sbjct: 653 GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLL----DFGCHPSLQDSEGDTPLHDAISKKRDDIL 579
             R+ R +TP+H++   GH+ V+  LL        +P+  D+ G T LH A     +  +
Sbjct: 713 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV 772

Query: 580 AVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639
            +LLE       T  N F+ LH A +  N  A  +L+  L    IV+     G T LH A
Sbjct: 773 ELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGAS-IVNATDSKGRTPLHAA 830

Query: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLV-RAGAKLDIQDKD 698
           A  +HVE  +LL+   NA ++  +   +T L +A E   T  V +LV  A A+L +QD  
Sbjct: 831 AFTDHVECLQLLLSH-NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889

Query: 699 GDTPLHEAL-RHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIAC 757
            +T LH A  + H  S L  L+ + D   ++A     +  L +      A +     +  
Sbjct: 890 KNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHV------AARNGLTMVVQ 943

Query: 758 FLAANGADLSIRNKKGQSPLDLC-PDPNLCKALA 790
            L   GA +   ++ G +P   C P+ ++   LA
Sbjct: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLA 977



 Score =  116 bits (291), Expect = 9e-26
 Identities = 95/346 (27%), Positives = 157/346 (45%), Gaps = 46/346 (13%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           LV+A  NGD  +V  L+ + + DVN Q     T + AA+  G  +I++LL+     V A+
Sbjct: 12  LVQAIFNGDPDEVRALIFKKE-DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           D      +H A        ++VL + SAD+NAR+K  QTPLHIA     ++  + L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613
            + ++ D  G T LH A      +++ +LL  GA++   +     A+H AA  G+   ++
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673
           +L+S        D+K    YT LH AA +  + V + L+  G  +++  N    T LH+A
Sbjct: 191 LLVSHGAEVTCKDKK---SYTPLHAAASSGMISVVKYLLDLG-VDMNEPNAYGNTPLHVA 246

Query: 674 VERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEP 733
                  +V  L+  GA ++ +++ G TPLH A                           
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA--------------------------- 279

Query: 734 SKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
                        A     A     L  NGAD+++++K G++PL +
Sbjct: 280 -------------AASTHGALCLELLVGNGADVNMKSKDGKTPLHM 312



 Score =  103 bits (256), Expect = 1e-21
 Identities = 92/332 (27%), Positives = 155/332 (46%), Gaps = 27/332 (8%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T + AA+  G+++ L LLL    D   +DK G   +H+AA       +  L    A +
Sbjct: 405 GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464

Query: 524 NARNKRRQTPLHIAVNKG-HLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR------- 575
           N  ++R  TPLH A       + ++ LL    +P ++D +G   +H + +          
Sbjct: 465 NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524

Query: 576 --DDILAVLLE-AGADVTITNNNG--FNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKD 630
             +  L VL+E +G D+   ++N    + LH AA  G+  A+ VL+  L     +D +  
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD---LDVRNS 581

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLV---R 687
            G T L LAA   HVE  ++L++QG + L    + ++T +H A    H++ +RLL+    
Sbjct: 582 SGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAE 641

Query: 688 AGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGA 747
               +DIQD +G TPL  ++ +     +  L  +     VDA  +  +  L  G  T   
Sbjct: 642 PQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL--LNKGANVDAKDKWGRTALHRGAVTGHE 699

Query: 748 EKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
           E   A      L  +GA   +R+ +G++P+ L
Sbjct: 700 ECVDA------LLQHGAKCLLRDSRGRTPIHL 725



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 92/355 (25%), Positives = 142/355 (40%), Gaps = 12/355 (3%)

Query: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDI-LKLLLKQNVDV 490
           N  L  A  NG    V +L+    +       G T +  A+ + H  + L+LL+    DV
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299

Query: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
             + KDG   +H  A     +  + + +  A ++  +K   TPLHIA   GH  ++ TL+
Sbjct: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359

Query: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G   + +   G  PLH A      D    LL +G D+   ++ G   LH AA  GN  
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419

Query: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTAL 670
            + +LL+        ++K   G + LH AA N + +    LV  G +  D+         
Sbjct: 420 CLNLLLNTGAD---FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476

Query: 671 HLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH--EALRHHTLSQL----RQLQDMQDV 724
           + A      + +  L+R  A   I+DK G   +H   A  H    QL      L  + + 
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET 536

Query: 725 GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
              D   +      I  L          A     L  +  DL +RN  G++PLDL
Sbjct: 537 SGTDMLSDSDNRATISPLHLAAYHGHHQALEV--LVQSLLDLDVRNSSGRTPLDL 589



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 70/256 (27%), Positives = 125/256 (48%), Gaps = 8/256 (3%)

Query: 438 AAANGDVAKVEDLLKRP-DVDVNGQCA---GHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           +AA G +  +  LL+    +D N   A   G+TA+  A  NGH   ++LLL+Q V  + E
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785

Query: 494 DKDGDRAVHHAAFGDEGAVIEVL--HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
             +    +H A   D     E+L    G++ +NA + + +TPLH A    H++ ++ LL 
Sbjct: 786 G-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLE-AGADVTITNNNGFNALHHAALRGNPS 610
                +  DS G TPL  A    + + + +L+  A A++T+ +N+   ALH A  +G+ +
Sbjct: 845 HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 904

Query: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTAL 670
           +  ++L K+    +++       T LH+AA N    V + L+ +G + L +       AL
Sbjct: 905 SALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPAL 964

Query: 671 HLAVERQHTQIVRLLV 686
             A  +     + L++
Sbjct: 965 ACAPNKDVADCLALIL 980


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  137 bits (345), Expect = 5e-32
 Identities = 94/287 (32%), Positives = 158/287 (55%), Gaps = 10/287 (3%)

Query: 424 ETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKL 482
           + ++  D     ++AA +G++ K  D L R  VD+N     G   +  AS+ GHV ++  
Sbjct: 38  DRKKKADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96

Query: 483 LLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGH 542
           LL + + +E   K G+ A+H AA   +  V+  L    A++NA++++  TPL++A  + H
Sbjct: 97  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156

Query: 543 LQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 602
           L+VVK LL+ G + ++   +G TPL  A+ +  ++++A L+  G    +       ALH 
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 212

Query: 603 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 662
           AA   +     VLL   P P   D     G+T LH+AA   ++ VA+LL+++G A+++  
Sbjct: 213 AARNDDTRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYENLNVAQLLLNRG-ASVNFT 268

Query: 663 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
             N  T LH+A  R +  +VRLL+  GA+++ + KD  TPLH A R+
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315



 Score =  137 bits (344), Expect = 7e-32
 Identities = 90/271 (33%), Positives = 139/271 (51%), Gaps = 4/271 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G+V  V  LL R            T +  A++NGHV I ++LL     ++A+ K+G
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA GD    + +L +  A+++       TPLH+A + GH +V K LLD G  P+
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +   G TPLH A  K    ++ +LL+ GA +     +G   LH A+  G+   ++ LL 
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 458

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +   P + + K +   T LH+AA   H EVA+ L+ Q  A ++ +  + QT LH A    
Sbjct: 459 RGASPNVSNVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIG 514

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           HT +V+LL+   A  ++    G TPLH A R
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAR 545



 Score =  125 bits (313), Expect = 3e-28
 Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A +  HV +++LLLK    ++A  + G   +H A+F     +++ L +  A  
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  N + +TPLH+A   GH +V K LL      + +  +  TPLH A      +++ +LL
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           E  A+  +    G   LH AA  G+   +  LL K      + +K   G+T LH+AA   
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYG 580

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            V VAELL+ + +A+ +    N  T LH+AV   +  IV+LL+  G        +G TPL
Sbjct: 581 KVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 639

Query: 704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           H A + + +   R L  +Q  G  +A        L +      A ++  A +   L +  
Sbjct: 640 HIAAKQNQVEVARSL--LQYGGSANAESVQGVTPLHL------AAQEGHAEMVALLLSKQ 691

Query: 764 ADLSIRNKKGQSPLDL 779
           A+ ++ NK G +PL L
Sbjct: 692 ANGNLGNKSGLTPLHL 707



 Score =  123 bits (309), Expect = 8e-28
 Identities = 115/403 (28%), Positives = 174/403 (43%), Gaps = 51/403 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           +V +LL +    ++    +G T +  AS  GH+ I+K LL++       +   +  +H A
Sbjct: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A      V + L +  A +NA+ K  QTPLH A   GH  +VK LL+   +P+L  + G 
Sbjct: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 537

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK------ 618
           TPLH A  +   + +  LLE  A        GF  LH AA  G      +LL +      
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597

Query: 619 ------------------------LPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVH 653
                                   LPR         +GYT LH+AA  N VEVA  LL +
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G+AN   ++V   T LHLA +  H ++V LL+   A  ++ +K G TPLH   +   + 
Sbjct: 658 GGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               L  ++    VDA        L +      A       +  FL  + AD++ + K G
Sbjct: 716 VADVL--IKHGVMVDATTRMGYTPLHV------ASHYGNIKLVKFLLQHQADVNAKTKLG 767

Query: 774 QSPLDLCPDPNLCKALAKCHKEKVSGQV-GSRSPSMISNDSET 815
            SPL         +A  + H + V+  +    SP+ +S+D  T
Sbjct: 768 YSPLH--------QAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802



 Score =  120 bits (300), Expect = 8e-27
 Identities = 95/343 (27%), Positives = 162/343 (47%), Gaps = 14/343 (4%)

Query: 438 AAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA N D      LL+  P+ DV  +  G T +  A+   ++++ +LLL +   V    ++
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H A+      ++ +L    A +  + K   TPLH A   GH+++ + LLD G   
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
             +   G +P+H A      D + +LL+  A++     +    LH AA  G+    +VLL
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
            K  +P   + +  +G+T LH+A   NHV V ELL+  G A++D    +  T LH+A   
Sbjct: 392 DKGAKP---NSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFM 447

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H  IV+ L++ GA  ++ +   +TPLH A R       + L  +Q+  KV+A  +  + 
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL--LQNKAKVNAKAKDDQT 505

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
            L        A +    ++   L  N A+ ++    G +PL +
Sbjct: 506 PL------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542



 Score =  119 bits (297), Expect = 2e-26
 Identities = 100/374 (26%), Positives = 154/374 (41%), Gaps = 47/374 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G +  V++LL+R            T +  A++ GH ++ K LL+    V A+ KD 
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA      ++++L   +A+ N       TPLHIA  +GH++ V  LL+     +
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
               +G TPLH A    +  +  +LLE  A       NG   LH A    N   +++LL 
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL- 622

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN--------------------- 656
             PR         +GYT LH+AA  N VEVA  L+  G                      
Sbjct: 623 --PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 680

Query: 657 -----------ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHE 705
                      AN ++ N +  T LHL  +  H  +  +L++ G  +D   + G TPLH 
Sbjct: 681 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 740

Query: 706 ALRHHTLSQLR-QLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           A  +  +  ++  LQ   DV  K    + P             A ++    I   L  NG
Sbjct: 741 ASHYGNIKLVKFLLQHQADVNAKTKLGYSP----------LHQAAQQGHTDIVTLLLKNG 790

Query: 764 ADLSIRNKKGQSPL 777
           A  +  +  G +PL
Sbjct: 791 ASPNEVSSDGTTPL 804



 Score =  112 bits (280), Expect = 2e-24
 Identities = 86/311 (27%), Positives = 149/311 (47%), Gaps = 12/311 (3%)

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
           A+  A++N       +LL+ + + +   K G   +H AA  +   V ++L    A +N  
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLHIA  +G++ +V+ LLD G     +  +  TPLH A       I  +LL+ G
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A +     NG + +H AA   +   +R+LL        +D+   D  T LH+AA   H  
Sbjct: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHR 385

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           VA++L+ +G A  + + +N  T LH+A ++ H +++ LL++ GA +D   + G TPLH A
Sbjct: 386 VAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 444

Query: 707 LRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766
                L  ++ L        +     P+ + + +      A +     +A +L  N A +
Sbjct: 445 SFMGHLPIVKNL--------LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496

Query: 767 SIRNKKGQSPL 777
           + + K  Q+PL
Sbjct: 497 NAKAKDDQTPL 507



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 5/211 (2%)

Query: 441 NGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
           N D+ K+  LL R     +    G+T +  A++   V++ + LL+      AE   G   
Sbjct: 614 NLDIVKL--LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 671

Query: 501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQD 560
           +H AA      ++ +L    A+ N  NK   TPLH+   +GH+ V   L+  G       
Sbjct: 672 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 731

Query: 561 SEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
             G TPLH A       ++  LL+  ADV      G++ LH AA +G+   + +LL    
Sbjct: 732 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 791

Query: 621 RPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
            P   +E   DG T L +A    ++ V ++L
Sbjct: 792 SP---NEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           L  G D+   N NG N LH A+  G+   +++++  L +  I++     G TALH+AAL 
Sbjct: 65  LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEIILETTTKKGNTALHIAALA 121

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV   LV+ G AN++ Q+    T L++A +  H ++V+ L+  GA  ++  +DG TP
Sbjct: 122 GQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKV 727
           L  AL+    + +  L +    GKV
Sbjct: 181 LAVALQQGHENVVAHLINYGTKGKV 205



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%)

Query: 426 QESGDLNEELVK-------AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVD 478
           Q  G  N E V+       AA  G    V  LL +      G  +G T +   +Q GHV 
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           +  +L+K  V V+A  + G   +H A+      +++ L +  AD+NA+ K   +PLH A 
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR-----DDILAVLLEAGADVTITN 593
            +GH  +V  LL  G  P+   S+G TPL  AI+K+       D+L V+ +  + V +++
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRLGYISVTDVLKVVTDETSFVLVSD 833

Query: 594 NN 595
            +
Sbjct: 834 KH 835



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 42/147 (28%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G   LHLA+   HV++   L+H+    L+       TALH+A      ++VR LV  GA
Sbjct: 77  NGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q + G TPL+ A + + L  ++                                  
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVK---------------------------------- 161

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
                  FL  NGA+ ++  + G +PL
Sbjct: 162 -------FLLENGANQNVATEDGFTPL 181


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  137 bits (344), Expect = 7e-32
 Identities = 90/271 (33%), Positives = 139/271 (51%), Gaps = 4/271 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G+V  V  LL R            T +  A++NGHV I ++LL     ++A+ K+G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA GD    + +L +  A+++       TPLH+A + GH +V K LLD G  P+
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +   G TPLH A  K    ++ +LL+ GA +     +G   LH A+  G+   ++ LL 
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +   P + + K +   T LH+AA   H EVA+ L+ Q  A ++ +  + QT LH A    
Sbjct: 426 RGASPNVSNVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIG 481

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           HT +V+LL+   A  ++    G TPLH A R
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAR 512



 Score =  136 bits (342), Expect = 1e-31
 Identities = 94/281 (33%), Positives = 155/281 (55%), Gaps = 10/281 (3%)

Query: 430 DLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLKQNV 488
           D     ++AA +G++ K  D L R  VD+N     G   +  AS+ GHV ++  LL + +
Sbjct: 11  DAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 489 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT 548
            +E   K G+ A+H AA   +  V+  L    A++NA++++  TPL++A  + HL+VVK 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 549 LLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGN 608
           LL+ G + ++   +G TPL  A+ +  ++++A L+  G    +       ALH AA   +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDD 185

Query: 609 PSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQT 668
                VLL   P P   D     G+T LH+AA   ++ VA+LL+++G A+++    N  T
Sbjct: 186 TRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYENLNVAQLLLNRG-ASVNFTPQNGIT 241

Query: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
            LH+A  R +  +VRLL+  GA+++ + KD  TPLH A R+
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282



 Score =  125 bits (313), Expect = 3e-28
 Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A +  HV +++LLLK    ++A  + G   +H A+F     +++ L +  A  
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  N + +TPLH+A   GH +V K LL      + +  +  TPLH A      +++ +LL
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           E  A+  +    G   LH AA  G+   +  LL K      + +K   G+T LH+AA   
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYG 547

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            V VAELL+ + +A+ +    N  T LH+AV   +  IV+LL+  G        +G TPL
Sbjct: 548 KVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           H A + + +   R L  +Q  G  +A        L +      A ++  A +   L +  
Sbjct: 607 HIAAKQNQVEVARSL--LQYGGSANAESVQGVTPLHL------AAQEGHAEMVALLLSKQ 658

Query: 764 ADLSIRNKKGQSPLDL 779
           A+ ++ NK G +PL L
Sbjct: 659 ANGNLGNKSGLTPLHL 674



 Score =  123 bits (309), Expect = 8e-28
 Identities = 115/403 (28%), Positives = 174/403 (43%), Gaps = 51/403 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           +V +LL +    ++    +G T +  AS  GH+ I+K LL++       +   +  +H A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A      V + L +  A +NA+ K  QTPLH A   GH  +VK LL+   +P+L  + G 
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK------ 618
           TPLH A  +   + +  LLE  A        GF  LH AA  G      +LL +      
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 619 ------------------------LPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVH 653
                                   LPR         +GYT LH+AA  N VEVA  LL +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G+AN   ++V   T LHLA +  H ++V LL+   A  ++ +K G TPLH   +   + 
Sbjct: 625 GGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               L  ++    VDA        L +      A       +  FL  + AD++ + K G
Sbjct: 683 VADVL--IKHGVMVDATTRMGYTPLHV------ASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 774 QSPLDLCPDPNLCKALAKCHKEKVSGQV-GSRSPSMISNDSET 815
            SPL         +A  + H + V+  +    SP+ +S+D  T
Sbjct: 735 YSPLH--------QAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769



 Score =  120 bits (300), Expect = 8e-27
 Identities = 95/343 (27%), Positives = 162/343 (47%), Gaps = 14/343 (4%)

Query: 438 AAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA N D      LL+  P+ DV  +  G T +  A+   ++++ +LLL +   V    ++
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H A+      ++ +L    A +  + K   TPLH A   GH+++ + LLD G   
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
             +   G +P+H A      D + +LL+  A++     +    LH AA  G+    +VLL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
            K  +P   + +  +G+T LH+A   NHV V ELL+  G A++D    +  T LH+A   
Sbjct: 359 DKGAKP---NSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFM 414

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H  IV+ L++ GA  ++ +   +TPLH A R       + L  +Q+  KV+A  +  + 
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL--LQNKAKVNAKAKDDQT 472

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
            L        A +    ++   L  N A+ ++    G +PL +
Sbjct: 473 PL------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score =  119 bits (297), Expect = 2e-26
 Identities = 100/374 (26%), Positives = 154/374 (41%), Gaps = 47/374 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G +  V++LL+R            T +  A++ GH ++ K LL+    V A+ KD 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA      ++++L   +A+ N       TPLHIA  +GH++ V  LL+     +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
               +G TPLH A    +  +  +LLE  A       NG   LH A    N   +++LL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL- 589

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN--------------------- 656
             PR         +GYT LH+AA  N VEVA  L+  G                      
Sbjct: 590 --PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647

Query: 657 -----------ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHE 705
                      AN ++ N +  T LHL  +  H  +  +L++ G  +D   + G TPLH 
Sbjct: 648 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707

Query: 706 ALRHHTLSQLR-QLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           A  +  +  ++  LQ   DV  K    + P             A ++    I   L  NG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSP----------LHQAAQQGHTDIVTLLLKNG 757

Query: 764 ADLSIRNKKGQSPL 777
           A  +  +  G +PL
Sbjct: 758 ASPNEVSSDGTTPL 771



 Score =  112 bits (280), Expect = 2e-24
 Identities = 86/311 (27%), Positives = 149/311 (47%), Gaps = 12/311 (3%)

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
           A+  A++N       +LL+ + + +   K G   +H AA  +   V ++L    A +N  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLHIA  +G++ +V+ LLD G     +  +  TPLH A       I  +LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A +     NG + +H AA   +   +R+LL        +D+   D  T LH+AA   H  
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHR 352

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           VA++L+ +G A  + + +N  T LH+A ++ H +++ LL++ GA +D   + G TPLH A
Sbjct: 353 VAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411

Query: 707 LRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766
                L  ++ L        +     P+ + + +      A +     +A +L  N A +
Sbjct: 412 SFMGHLPIVKNL--------LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 767 SIRNKKGQSPL 777
           + + K  Q+PL
Sbjct: 464 NAKAKDDQTPL 474



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 5/211 (2%)

Query: 441 NGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
           N D+ K+  LL R     +    G+T +  A++   V++ + LL+      AE   G   
Sbjct: 581 NLDIVKL--LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 638

Query: 501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQD 560
           +H AA      ++ +L    A+ N  NK   TPLH+   +GH+ V   L+  G       
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698

Query: 561 SEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
             G TPLH A       ++  LL+  ADV      G++ LH AA +G+   + +LL    
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758

Query: 621 RPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
            P   +E   DG T L +A    ++ V ++L
Sbjct: 759 SP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           L  G D+   N NG N LH A+  G+   +++++  L +  I++     G TALH+AAL 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV   LV+ G AN++ Q+    T L++A +  H ++V+ L+  GA  ++  +DG TP
Sbjct: 89  GQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKV 727
           L  AL+    + +  L +    GKV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV 172



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%)

Query: 426 QESGDLNEELVK-------AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVD 478
           Q  G  N E V+       AA  G    V  LL +      G  +G T +   +Q GHV 
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           +  +L+K  V V+A  + G   +H A+      +++ L +  AD+NA+ K   +PLH A 
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR-----DDILAVLLEAGADVTITN 593
            +GH  +V  LL  G  P+   S+G TPL  AI+K+       D+L V+ +  + V +++
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 594 NN 595
            +
Sbjct: 801 KH 802



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 42/147 (28%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G   LHLA+   HV++   L+H+    L+       TALH+A      ++VR LV  GA
Sbjct: 44  NGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q + G TPL+ A + + L  ++                                  
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVK---------------------------------- 128

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
                  FL  NGA+ ++  + G +PL
Sbjct: 129 -------FLLENGANQNVATEDGFTPL 148


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  137 bits (344), Expect = 7e-32
 Identities = 90/271 (33%), Positives = 139/271 (51%), Gaps = 4/271 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G+V  V  LL R            T +  A++NGHV I ++LL     ++A+ K+G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA GD    + +L +  A+++       TPLH+A + GH +V K LLD G  P+
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +   G TPLH A  K    ++ +LL+ GA +     +G   LH A+  G+   ++ LL 
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +   P + + K +   T LH+AA   H EVA+ L+ Q  A ++ +  + QT LH A    
Sbjct: 426 RGASPNVSNVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIG 481

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           HT +V+LL+   A  ++    G TPLH A R
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAR 512



 Score =  136 bits (342), Expect = 1e-31
 Identities = 94/281 (33%), Positives = 155/281 (55%), Gaps = 10/281 (3%)

Query: 430 DLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLKQNV 488
           D     ++AA +G++ K  D L R  VD+N     G   +  AS+ GHV ++  LL + +
Sbjct: 11  DAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 489 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT 548
            +E   K G+ A+H AA   +  V+  L    A++NA++++  TPL++A  + HL+VVK 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 549 LLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGN 608
           LL+ G + ++   +G TPL  A+ +  ++++A L+  G    +       ALH AA   +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDD 185

Query: 609 PSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQT 668
                VLL   P P   D     G+T LH+AA   ++ VA+LL+++G A+++    N  T
Sbjct: 186 TRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYENLNVAQLLLNRG-ASVNFTPQNGIT 241

Query: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
            LH+A  R +  +VRLL+  GA+++ + KD  TPLH A R+
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282



 Score =  125 bits (313), Expect = 3e-28
 Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A +  HV +++LLLK    ++A  + G   +H A+F     +++ L +  A  
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  N + +TPLH+A   GH +V K LL      + +  +  TPLH A      +++ +LL
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           E  A+  +    G   LH AA  G+   +  LL K      + +K   G+T LH+AA   
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYG 547

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            V VAELL+ + +A+ +    N  T LH+AV   +  IV+LL+  G        +G TPL
Sbjct: 548 KVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           H A + + +   R L  +Q  G  +A        L +      A ++  A +   L +  
Sbjct: 607 HIAAKQNQVEVARSL--LQYGGSANAESVQGVTPLHL------AAQEGHAEMVALLLSKQ 658

Query: 764 ADLSIRNKKGQSPLDL 779
           A+ ++ NK G +PL L
Sbjct: 659 ANGNLGNKSGLTPLHL 674



 Score =  123 bits (309), Expect = 8e-28
 Identities = 115/403 (28%), Positives = 174/403 (43%), Gaps = 51/403 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           +V +LL +    ++    +G T +  AS  GH+ I+K LL++       +   +  +H A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A      V + L +  A +NA+ K  QTPLH A   GH  +VK LL+   +P+L  + G 
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK------ 618
           TPLH A  +   + +  LLE  A        GF  LH AA  G      +LL +      
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 619 ------------------------LPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVH 653
                                   LPR         +GYT LH+AA  N VEVA  LL +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G+AN   ++V   T LHLA +  H ++V LL+   A  ++ +K G TPLH   +   + 
Sbjct: 625 GGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               L  ++    VDA        L +      A       +  FL  + AD++ + K G
Sbjct: 683 VADVL--IKHGVMVDATTRMGYTPLHV------ASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 774 QSPLDLCPDPNLCKALAKCHKEKVSGQV-GSRSPSMISNDSET 815
            SPL         +A  + H + V+  +    SP+ +S+D  T
Sbjct: 735 YSPLH--------QAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769



 Score =  120 bits (300), Expect = 8e-27
 Identities = 95/343 (27%), Positives = 162/343 (47%), Gaps = 14/343 (4%)

Query: 438 AAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA N D      LL+  P+ DV  +  G T +  A+   ++++ +LLL +   V    ++
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H A+      ++ +L    A +  + K   TPLH A   GH+++ + LLD G   
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
             +   G +P+H A      D + +LL+  A++     +    LH AA  G+    +VLL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
            K  +P   + +  +G+T LH+A   NHV V ELL+  G A++D    +  T LH+A   
Sbjct: 359 DKGAKP---NSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFM 414

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H  IV+ L++ GA  ++ +   +TPLH A R       + L  +Q+  KV+A  +  + 
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL--LQNKAKVNAKAKDDQT 472

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
            L        A +    ++   L  N A+ ++    G +PL +
Sbjct: 473 PL------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score =  119 bits (297), Expect = 2e-26
 Identities = 100/374 (26%), Positives = 154/374 (41%), Gaps = 47/374 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G +  V++LL+R            T +  A++ GH ++ K LL+    V A+ KD 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA      ++++L   +A+ N       TPLHIA  +GH++ V  LL+     +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
               +G TPLH A    +  +  +LLE  A       NG   LH A    N   +++LL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL- 589

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN--------------------- 656
             PR         +GYT LH+AA  N VEVA  L+  G                      
Sbjct: 590 --PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647

Query: 657 -----------ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHE 705
                      AN ++ N +  T LHL  +  H  +  +L++ G  +D   + G TPLH 
Sbjct: 648 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707

Query: 706 ALRHHTLSQLR-QLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           A  +  +  ++  LQ   DV  K    + P             A ++    I   L  NG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSP----------LHQAAQQGHTDIVTLLLKNG 757

Query: 764 ADLSIRNKKGQSPL 777
           A  +  +  G +PL
Sbjct: 758 ASPNEVSSDGTTPL 771



 Score =  112 bits (280), Expect = 2e-24
 Identities = 86/311 (27%), Positives = 149/311 (47%), Gaps = 12/311 (3%)

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
           A+  A++N       +LL+ + + +   K G   +H AA  +   V ++L    A +N  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLHIA  +G++ +V+ LLD G     +  +  TPLH A       I  +LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A +     NG + +H AA   +   +R+LL        +D+   D  T LH+AA   H  
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHR 352

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           VA++L+ +G A  + + +N  T LH+A ++ H +++ LL++ GA +D   + G TPLH A
Sbjct: 353 VAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411

Query: 707 LRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766
                L  ++ L        +     P+ + + +      A +     +A +L  N A +
Sbjct: 412 SFMGHLPIVKNL--------LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 767 SIRNKKGQSPL 777
           + + K  Q+PL
Sbjct: 464 NAKAKDDQTPL 474



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 5/211 (2%)

Query: 441 NGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
           N D+ K+  LL R     +    G+T +  A++   V++ + LL+      AE   G   
Sbjct: 581 NLDIVKL--LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 638

Query: 501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQD 560
           +H AA      ++ +L    A+ N  NK   TPLH+   +GH+ V   L+  G       
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698

Query: 561 SEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
             G TPLH A       ++  LL+  ADV      G++ LH AA +G+   + +LL    
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758

Query: 621 RPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
            P   +E   DG T L +A    ++ V ++L
Sbjct: 759 SP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           L  G D+   N NG N LH A+  G+   +++++  L +  I++     G TALH+AAL 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV   LV+ G AN++ Q+    T L++A +  H ++V+ L+  GA  ++  +DG TP
Sbjct: 89  GQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKV 727
           L  AL+    + +  L +    GKV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV 172



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%)

Query: 426 QESGDLNEELVK-------AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVD 478
           Q  G  N E V+       AA  G    V  LL +      G  +G T +   +Q GHV 
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           +  +L+K  V V+A  + G   +H A+      +++ L +  AD+NA+ K   +PLH A 
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR-----DDILAVLLEAGADVTITN 593
            +GH  +V  LL  G  P+   S+G TPL  AI+K+       D+L V+ +  + V +++
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 594 NN 595
            +
Sbjct: 801 KH 802



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 42/147 (28%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G   LHLA+   HV++   L+H+    L+       TALH+A      ++VR LV  GA
Sbjct: 44  NGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q + G TPL+ A + + L  ++                                  
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVK---------------------------------- 128

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
                  FL  NGA+ ++  + G +PL
Sbjct: 129 -------FLLENGANQNVATEDGFTPL 148


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  137 bits (344), Expect = 7e-32
 Identities = 90/271 (33%), Positives = 139/271 (51%), Gaps = 4/271 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G+V  V  LL R            T +  A++NGHV I ++LL     ++A+ K+G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA GD    + +L +  A+++       TPLH+A + GH +V K LLD G  P+
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +   G TPLH A  K    ++ +LL+ GA +     +G   LH A+  G+   ++ LL 
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +   P + + K +   T LH+AA   H EVA+ L+ Q  A ++ +  + QT LH A    
Sbjct: 426 RGASPNVSNVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIG 481

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           HT +V+LL+   A  ++    G TPLH A R
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAR 512



 Score =  136 bits (342), Expect = 1e-31
 Identities = 94/281 (33%), Positives = 155/281 (55%), Gaps = 10/281 (3%)

Query: 430 DLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLKQNV 488
           D     ++AA +G++ K  D L R  VD+N     G   +  AS+ GHV ++  LL + +
Sbjct: 11  DAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 489 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT 548
            +E   K G+ A+H AA   +  V+  L    A++NA++++  TPL++A  + HL+VVK 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 549 LLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGN 608
           LL+ G + ++   +G TPL  A+ +  ++++A L+  G    +       ALH AA   +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDD 185

Query: 609 PSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQT 668
                VLL   P P   D     G+T LH+AA   ++ VA+LL+++G A+++    N  T
Sbjct: 186 TRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYENLNVAQLLLNRG-ASVNFTPQNGIT 241

Query: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
            LH+A  R +  +VRLL+  GA+++ + KD  TPLH A R+
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282



 Score =  125 bits (313), Expect = 3e-28
 Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A +  HV +++LLLK    ++A  + G   +H A+F     +++ L +  A  
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  N + +TPLH+A   GH +V K LL      + +  +  TPLH A      +++ +LL
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           E  A+  +    G   LH AA  G+   +  LL K      + +K   G+T LH+AA   
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYG 547

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            V VAELL+ + +A+ +    N  T LH+AV   +  IV+LL+  G        +G TPL
Sbjct: 548 KVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           H A + + +   R L  +Q  G  +A        L +      A ++  A +   L +  
Sbjct: 607 HIAAKQNQVEVARSL--LQYGGSANAESVQGVTPLHL------AAQEGHAEMVALLLSKQ 658

Query: 764 ADLSIRNKKGQSPLDL 779
           A+ ++ NK G +PL L
Sbjct: 659 ANGNLGNKSGLTPLHL 674



 Score =  123 bits (309), Expect = 8e-28
 Identities = 115/403 (28%), Positives = 174/403 (43%), Gaps = 51/403 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           +V +LL +    ++    +G T +  AS  GH+ I+K LL++       +   +  +H A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A      V + L +  A +NA+ K  QTPLH A   GH  +VK LL+   +P+L  + G 
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK------ 618
           TPLH A  +   + +  LLE  A        GF  LH AA  G      +LL +      
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 619 ------------------------LPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVH 653
                                   LPR         +GYT LH+AA  N VEVA  LL +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G+AN   ++V   T LHLA +  H ++V LL+   A  ++ +K G TPLH   +   + 
Sbjct: 625 GGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               L  ++    VDA        L +      A       +  FL  + AD++ + K G
Sbjct: 683 VADVL--IKHGVMVDATTRMGYTPLHV------ASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 774 QSPLDLCPDPNLCKALAKCHKEKVSGQV-GSRSPSMISNDSET 815
            SPL         +A  + H + V+  +    SP+ +S+D  T
Sbjct: 735 YSPLH--------QAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769



 Score =  120 bits (300), Expect = 8e-27
 Identities = 95/343 (27%), Positives = 162/343 (47%), Gaps = 14/343 (4%)

Query: 438 AAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA N D      LL+  P+ DV  +  G T +  A+   ++++ +LLL +   V    ++
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H A+      ++ +L    A +  + K   TPLH A   GH+++ + LLD G   
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
             +   G +P+H A      D + +LL+  A++     +    LH AA  G+    +VLL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
            K  +P   + +  +G+T LH+A   NHV V ELL+  G A++D    +  T LH+A   
Sbjct: 359 DKGAKP---NSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFM 414

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H  IV+ L++ GA  ++ +   +TPLH A R       + L  +Q+  KV+A  +  + 
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL--LQNKAKVNAKAKDDQT 472

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
            L        A +    ++   L  N A+ ++    G +PL +
Sbjct: 473 PL------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score =  119 bits (297), Expect = 2e-26
 Identities = 100/374 (26%), Positives = 154/374 (41%), Gaps = 47/374 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G +  V++LL+R            T +  A++ GH ++ K LL+    V A+ KD 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA      ++++L   +A+ N       TPLHIA  +GH++ V  LL+     +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
               +G TPLH A    +  +  +LLE  A       NG   LH A    N   +++LL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL- 589

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN--------------------- 656
             PR         +GYT LH+AA  N VEVA  L+  G                      
Sbjct: 590 --PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647

Query: 657 -----------ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHE 705
                      AN ++ N +  T LHL  +  H  +  +L++ G  +D   + G TPLH 
Sbjct: 648 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707

Query: 706 ALRHHTLSQLR-QLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           A  +  +  ++  LQ   DV  K    + P             A ++    I   L  NG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSP----------LHQAAQQGHTDIVTLLLKNG 757

Query: 764 ADLSIRNKKGQSPL 777
           A  +  +  G +PL
Sbjct: 758 ASPNEVSSDGTTPL 771



 Score =  112 bits (280), Expect = 2e-24
 Identities = 86/311 (27%), Positives = 149/311 (47%), Gaps = 12/311 (3%)

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
           A+  A++N       +LL+ + + +   K G   +H AA  +   V ++L    A +N  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLHIA  +G++ +V+ LLD G     +  +  TPLH A       I  +LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A +     NG + +H AA   +   +R+LL        +D+   D  T LH+AA   H  
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHR 352

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           VA++L+ +G A  + + +N  T LH+A ++ H +++ LL++ GA +D   + G TPLH A
Sbjct: 353 VAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411

Query: 707 LRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766
                L  ++ L        +     P+ + + +      A +     +A +L  N A +
Sbjct: 412 SFMGHLPIVKNL--------LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 767 SIRNKKGQSPL 777
           + + K  Q+PL
Sbjct: 464 NAKAKDDQTPL 474



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 5/211 (2%)

Query: 441 NGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
           N D+ K+  LL R     +    G+T +  A++   V++ + LL+      AE   G   
Sbjct: 581 NLDIVKL--LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 638

Query: 501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQD 560
           +H AA      ++ +L    A+ N  NK   TPLH+   +GH+ V   L+  G       
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698

Query: 561 SEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
             G TPLH A       ++  LL+  ADV      G++ LH AA +G+   + +LL    
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758

Query: 621 RPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
            P   +E   DG T L +A    ++ V ++L
Sbjct: 759 SP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           L  G D+   N NG N LH A+  G+   +++++  L +  I++     G TALH+AAL 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV   LV+ G AN++ Q+    T L++A +  H ++V+ L+  GA  ++  +DG TP
Sbjct: 89  GQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKV 727
           L  AL+    + +  L +    GKV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV 172



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%)

Query: 426 QESGDLNEELVK-------AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVD 478
           Q  G  N E V+       AA  G    V  LL +      G  +G T +   +Q GHV 
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           +  +L+K  V V+A  + G   +H A+      +++ L +  AD+NA+ K   +PLH A 
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR-----DDILAVLLEAGADVTITN 593
            +GH  +V  LL  G  P+   S+G TPL  AI+K+       D+L V+ +  + V +++
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 594 NN 595
            +
Sbjct: 801 KH 802



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 42/147 (28%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G   LHLA+   HV++   L+H+    L+       TALH+A      ++VR LV  GA
Sbjct: 44  NGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q + G TPL+ A + + L  ++                                  
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVK---------------------------------- 128

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
                  FL  NGA+ ++  + G +PL
Sbjct: 129 -------FLLENGANQNVATEDGFTPL 148


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  137 bits (344), Expect = 7e-32
 Identities = 90/271 (33%), Positives = 139/271 (51%), Gaps = 4/271 (1%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G+V  V  LL R            T +  A++NGHV I ++LL     ++A+ K+G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA GD    + +L +  A+++       TPLH+A + GH +V K LLD G  P+
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +   G TPLH A  K    ++ +LL+ GA +     +G   LH A+  G+   ++ LL 
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
           +   P + + K +   T LH+AA   H EVA+ L+ Q  A ++ +  + QT LH A    
Sbjct: 426 RGASPNVSNVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIG 481

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           HT +V+LL+   A  ++    G TPLH A R
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAR 512



 Score =  136 bits (342), Expect = 1e-31
 Identities = 94/281 (33%), Positives = 155/281 (55%), Gaps = 10/281 (3%)

Query: 430 DLNEELVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLKQNV 488
           D     ++AA +G++ K  D L R  VD+N     G   +  AS+ GHV ++  LL + +
Sbjct: 11  DAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 489 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT 548
            +E   K G+ A+H AA   +  V+  L    A++NA++++  TPL++A  + HL+VVK 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 549 LLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGN 608
           LL+ G + ++   +G TPL  A+ +  ++++A L+  G    +       ALH AA   +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDD 185

Query: 609 PSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQT 668
                VLL   P P   D     G+T LH+AA   ++ VA+LL+++G A+++    N  T
Sbjct: 186 TRTAAVLLQNDPNP---DVLSKTGFTPLHIAAHYENLNVAQLLLNRG-ASVNFTPQNGIT 241

Query: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
            LH+A  R +  +VRLL+  GA+++ + KD  TPLH A R+
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282



 Score =  125 bits (313), Expect = 3e-28
 Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A +  HV +++LLLK    ++A  + G   +H A+F     +++ L +  A  
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  N + +TPLH+A   GH +V K LL      + +  +  TPLH A      +++ +LL
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           E  A+  +    G   LH AA  G+   +  LL K      + +K   G+T LH+AA   
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYG 547

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            V VAELL+ + +A+ +    N  T LH+AV   +  IV+LL+  G        +G TPL
Sbjct: 548 KVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           H A + + +   R L  +Q  G  +A        L +      A ++  A +   L +  
Sbjct: 607 HIAAKQNQVEVARSL--LQYGGSANAESVQGVTPLHL------AAQEGHAEMVALLLSKQ 658

Query: 764 ADLSIRNKKGQSPLDL 779
           A+ ++ NK G +PL L
Sbjct: 659 ANGNLGNKSGLTPLHL 674



 Score =  123 bits (309), Expect = 8e-28
 Identities = 115/403 (28%), Positives = 174/403 (43%), Gaps = 51/403 (12%)

Query: 446 KVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHA 504
           +V +LL +    ++    +G T +  AS  GH+ I+K LL++       +   +  +H A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 505 AFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD 564
           A      V + L +  A +NA+ K  QTPLH A   GH  +VK LL+   +P+L  + G 
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK------ 618
           TPLH A  +   + +  LLE  A        GF  LH AA  G      +LL +      
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 619 ------------------------LPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVH 653
                                   LPR         +GYT LH+AA  N VEVA  LL +
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G+AN   ++V   T LHLA +  H ++V LL+   A  ++ +K G TPLH   +   + 
Sbjct: 625 GGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               L  ++    VDA        L +      A       +  FL  + AD++ + K G
Sbjct: 683 VADVL--IKHGVMVDATTRMGYTPLHV------ASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 774 QSPLDLCPDPNLCKALAKCHKEKVSGQV-GSRSPSMISNDSET 815
            SPL         +A  + H + V+  +    SP+ +S+D  T
Sbjct: 735 YSPLH--------QAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769



 Score =  120 bits (300), Expect = 8e-27
 Identities = 95/343 (27%), Positives = 162/343 (47%), Gaps = 14/343 (4%)

Query: 438 AAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA N D      LL+  P+ DV  +  G T +  A+   ++++ +LLL +   V    ++
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
           G   +H A+      ++ +L    A +  + K   TPLH A   GH+++ + LLD G   
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
             +   G +P+H A      D + +LL+  A++     +    LH AA  G+    +VLL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
            K  +P   + +  +G+T LH+A   NHV V ELL+  G A++D    +  T LH+A   
Sbjct: 359 DKGAKP---NSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFM 414

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H  IV+ L++ GA  ++ +   +TPLH A R       + L  +Q+  KV+A  +  + 
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL--LQNKAKVNAKAKDDQT 472

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
            L        A +    ++   L  N A+ ++    G +PL +
Sbjct: 473 PL------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509



 Score =  119 bits (297), Expect = 2e-26
 Identities = 100/374 (26%), Positives = 154/374 (41%), Gaps = 47/374 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           A+  G +  V++LL+R            T +  A++ GH ++ K LL+    V A+ KD 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA      ++++L   +A+ N       TPLHIA  +GH++ V  LL+     +
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
               +G TPLH A    +  +  +LLE  A       NG   LH A    N   +++LL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL- 589

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN--------------------- 656
             PR         +GYT LH+AA  N VEVA  L+  G                      
Sbjct: 590 --PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647

Query: 657 -----------ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHE 705
                      AN ++ N +  T LHL  +  H  +  +L++ G  +D   + G TPLH 
Sbjct: 648 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707

Query: 706 ALRHHTLSQLR-QLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 763
           A  +  +  ++  LQ   DV  K    + P             A ++    I   L  NG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSP----------LHQAAQQGHTDIVTLLLKNG 757

Query: 764 ADLSIRNKKGQSPL 777
           A  +  +  G +PL
Sbjct: 758 ASPNEVSSDGTTPL 771



 Score =  112 bits (280), Expect = 2e-24
 Identities = 86/311 (27%), Positives = 149/311 (47%), Gaps = 12/311 (3%)

Query: 467 AMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR 526
           A+  A++N       +LL+ + + +   K G   +H AA  +   V ++L    A +N  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 527 NKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG 586
            +   TPLHIA  +G++ +V+ LLD G     +  +  TPLH A       I  +LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 587 ADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE 646
           A +     NG + +H AA   +   +R+LL        +D+   D  T LH+AA   H  
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHR 352

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           VA++L+ +G A  + + +N  T LH+A ++ H +++ LL++ GA +D   + G TPLH A
Sbjct: 353 VAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411

Query: 707 LRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766
                L  ++ L        +     P+ + + +      A +     +A +L  N A +
Sbjct: 412 SFMGHLPIVKNL--------LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 767 SIRNKKGQSPL 777
           + + K  Q+PL
Sbjct: 464 NAKAKDDQTPL 474



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 5/211 (2%)

Query: 441 NGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
           N D+ K+  LL R     +    G+T +  A++   V++ + LL+      AE   G   
Sbjct: 581 NLDIVKL--LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 638

Query: 501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQD 560
           +H AA      ++ +L    A+ N  NK   TPLH+   +GH+ V   L+  G       
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698

Query: 561 SEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
             G TPLH A       ++  LL+  ADV      G++ LH AA +G+   + +LL    
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758

Query: 621 RPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
            P   +E   DG T L +A    ++ V ++L
Sbjct: 759 SP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           L  G D+   N NG N LH A+  G+   +++++  L +  I++     G TALH+AAL 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
              EV   LV+ G AN++ Q+    T L++A +  H ++V+ L+  GA  ++  +DG TP
Sbjct: 89  GQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKV 727
           L  AL+    + +  L +    GKV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV 172



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%)

Query: 426 QESGDLNEELVK-------AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVD 478
           Q  G  N E V+       AA  G    V  LL +      G  +G T +   +Q GHV 
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 479 ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAV 538
           +  +L+K  V V+A  + G   +H A+      +++ L +  AD+NA+ K   +PLH A 
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742

Query: 539 NKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR-----DDILAVLLEAGADVTITN 593
            +GH  +V  LL  G  P+   S+G TPL  AI+K+       D+L V+ +  + V +++
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 594 NN 595
            +
Sbjct: 801 KH 802



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 42/147 (28%)

Query: 631 DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
           +G   LHLA+   HV++   L+H+    L+       TALH+A      ++VR LV  GA
Sbjct: 44  NGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 691 KLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKK 750
            ++ Q + G TPL+ A + + L  ++                                  
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVK---------------------------------- 128

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
                  FL  NGA+ ++  + G +PL
Sbjct: 129 -------FLLENGANQNVATEDGFTPL 148


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  136 bits (342), Expect = 1e-31
 Identities = 90/268 (33%), Positives = 143/268 (53%), Gaps = 6/268 (2%)

Query: 435 LVKAAANGDVAKVEDLLKRPD-VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           L+ AA  G++  ++ L+KR   +DV  +  G  A+  A+++GHVD LK L +    ++ +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           DK G+ A+H AA      V ++L    ++ N ++K  +TPLH A   G+  V K L + G
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613
           C+ ++++ EG+TPL  A ++   DI+  L E GAD+   + +G  ALH A  R     ++
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561

Query: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673
            LLS   +   VD +   G T LH+A  + ++ +   L  + N NLDI N   +T LHLA
Sbjct: 562 TLLS---QGCFVDYQDRHGNTPLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLA 617

Query: 674 VERQHTQIVRLLVRAGAKLDIQDKDGDT 701
                  +VR L   GA ++    DG T
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKT 645



 Score =  126 bits (317), Expect = 9e-29
 Identities = 93/295 (31%), Positives = 144/295 (48%), Gaps = 6/295 (2%)

Query: 426 QESGDLNEELVKAAANGDVAKVEDLL-KRPDVDVNGQCA-GHTAMQAASQNGHVDILKLL 483
           +E   + + ++ A  + +V  ++ LL    + DVN     G   +  A+  G++ IL+LL
Sbjct: 339 EEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLL 398

Query: 484 LKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHL 543
           +K+   ++ +DK G  AV+ AA       ++ L      L+ ++K  +  LH+A   GH 
Sbjct: 399 IKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHA 458

Query: 544 QVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHA 603
            V + L  FG +P++QD E +TPLH A       +   L EAG +V I N  G   L  A
Sbjct: 459 DVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTA 518

Query: 604 ALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQN 663
           + RG    +  L          D+   DG+ ALHLA     +EV + L+ QG   +D Q+
Sbjct: 519 SARGYHDIVECLAEHGADLNACDK---DGHIALHLAVRRCQMEVIKTLLSQG-CFVDYQD 574

Query: 664 VNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
            +  T LH+A +  +  IV  L  A   LDI +K G TPLH A  +  L  +R L
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 42/136 (30%), Positives = 68/136 (50%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  AS  G+ DI++ L +   D+ A DKDG  A+H A    +  VI+ L      +
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           + +++   TPLH+A   G++ +V  L +  C+  + +  G TPLH A +    D++  L 
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630

Query: 584 EAGADVTITNNNGFNA 599
             GA V     +G  A
Sbjct: 631 LMGASVEALTTDGKTA 646



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 2/155 (1%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNG-QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           L+ A+A G    VE L +    D+N     GH A+  A +   ++++K LL Q   V+ +
Sbjct: 515 LLTASARGYHDIVECLAEH-GADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ 573

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           D+ G+  +H A       ++  L   + +L+  NK  +TPLH+A N G L VV+ L   G
Sbjct: 574 DRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMG 633

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 588
                  ++G T    A S++ + +  +L     D
Sbjct: 634 ASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 49/190 (25%), Positives = 84/190 (44%), Gaps = 45/190 (23%)

Query: 588 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 647
           DV   N +G   L  AA  GN   +++L+ +  R   +D +   G  A++ AA + HV+ 
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR---IDVQDKGGSNAVYWAARHGHVDT 427

Query: 648 AELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEAL 707
            + L  +    LD+++ + + ALH+A    H  + +LL   G+  +IQDK+ +TPLH   
Sbjct: 428 LKFL-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH--- 483

Query: 708 RHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLS 767
                                AAW                      S+A  L   G +++
Sbjct: 484 --------------------CAAWH------------------GYYSVAKALCEAGCNVN 505

Query: 768 IRNKKGQSPL 777
           I+N++G++PL
Sbjct: 506 IKNREGETPL 515



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 34/143 (23%), Positives = 71/143 (49%), Gaps = 10/143 (6%)

Query: 636 LHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQ 695
           +H    +N   +  LL    N +++  N +    L +A    + QI++LL++ G+++D+Q
Sbjct: 349 IHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ 408

Query: 696 DKDGDTPLHEALRHHTLSQLRQLQDMQ-DVGKVDAAWEPSKNTLIMGLGTQGAEKKSAAS 754
           DK G   ++ A RH  +  L+ L + +  +   D + E         +    A +   A 
Sbjct: 409 DKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGE---------MALHVAARYGHAD 459

Query: 755 IACFLAANGADLSIRNKKGQSPL 777
           +A  L + G++ +I++K+ ++PL
Sbjct: 460 VAQLLCSFGSNPNIQDKEEETPL 482


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  134 bits (337), Expect = 4e-31
 Identities = 104/344 (30%), Positives = 172/344 (50%), Gaps = 23/344 (6%)

Query: 394 PAAVSKVASAGSAISNASGERLSQL------------LKKLFETQES-GDLN------EE 434
           P  +S+ +S     S+ SG+RLS +            L   FE + S  DL       ++
Sbjct: 350 PEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKK 409

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
           LV A  +GD +K+  +L+  DVD+    +G + +  A + G  +  K LL  N +    +
Sbjct: 410 LVDAIVSGDTSKLMKILQPQDVDL-ALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468

Query: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
           + G   +H A       V+E+L      +NA+++ + T LH A   G     + LL+   
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528

Query: 555 HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRV 614
             +  D EG TP+H A    +++I+ +LL  G DV++   + +  LH+AA +G+   ++ 
Sbjct: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK- 587

Query: 615 LLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAV 674
           LL+K P    V+ +  DG T LHLAA   H  VA +L+    +++++ ++  QT LH+A 
Sbjct: 588 LLAKQPGV-SVNAQTLDGRTPLHLAAQRGHYRVARILIDL-CSDVNVCSLLAQTPLHVAA 645

Query: 675 ERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
           E  HT   RLL+  GA  +    DG T LH A R+  L+ ++ L
Sbjct: 646 ETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689



 Score =  124 bits (310), Expect = 6e-28
 Identities = 89/285 (31%), Positives = 142/285 (49%), Gaps = 18/285 (6%)

Query: 418 LLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHV 477
           L +K+    +  D    L  AA NGD +    LL++          G T M  A Q+G  
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 478 DILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG-SADLNARNKRRQTPLHI 536
           +I+++LL++ VDV  + KD    +H+AA+     ++++L +     +NA+    +TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 537 AVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNG 596
           A  +GH +V + L+D     ++      TPLH A          +LL  GA      ++G
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670

Query: 597 FNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDD------GYTALHLAALNNHVEVAEL 650
           + ALH AA  G+ + +++L         V+EK D         TALHLAA + H EV E 
Sbjct: 671 YTALHLAARNGHLATVKLL---------VEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721

Query: 651 LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQ 695
           LV      +D+ +    +ALHLA + +H Q V  L+R GA +++Q
Sbjct: 722 LVSADV--IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQ 764



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 78/232 (33%), Positives = 111/232 (47%), Gaps = 8/232 (3%)

Query: 438 AAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ-NVDVEAEDK 495
           A  +G    V  LL+R  DV + G+ A      AA Q GH+ I+KLL KQ  V V A+  
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ-GHLPIVKLLAKQPGVSVNAQTL 602

Query: 496 DGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
           DG   +H AA      V  +L    +D+N  +   QTPLH+A   GH    + LL  G  
Sbjct: 603 DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662

Query: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVL 615
                S+G T LH A        + +L+E  ADV         ALH AA  G+   +  L
Sbjct: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722

Query: 616 LSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQ 667
           +S      ++D   + G +ALHLAA   H +  E L+  G A++++Q++  Q
Sbjct: 723 VS----ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG-AHINLQSLKFQ 769


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  132 bits (333), Expect = 1e-30
 Identities = 87/254 (34%), Positives = 132/254 (51%), Gaps = 10/254 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAE--DKDGDRAVHHAAFGDEGAVIEVLHRGSA 521
           G T +  A+Q GHV +L  +++   DV  +  DK G  A H AA   +   ++ L     
Sbjct: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183

Query: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
           D N ++K   T LH+A  +GH+ V++ L+D G     Q++EG T LH A      D + +
Sbjct: 184 DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243

Query: 582 LLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL 641
           LL AG+ V        + LH+AAL G+    RVL+       +VD +   G + LHLA  
Sbjct: 244 LLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQ---GASPLHLAVR 300

Query: 642 NNHVEVAELLVHQGNANLDIQNVN--QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDG 699
           +N   +  LL+   N++ D+  V+  QQT LHLA E     I  +L+ AG  L+++DK G
Sbjct: 301 HNFPALVRLLI---NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357

Query: 700 DTPLHEALRHHTLS 713
            T L  A+R + +S
Sbjct: 358 KTALAVAVRSNHVS 371



 Score =  114 bits (286), Expect = 4e-25
 Identities = 101/368 (27%), Positives = 167/368 (45%), Gaps = 26/368 (7%)

Query: 423 FETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKL 482
           +ET     L  +L +AA   +V ++++L+ R          G  A+  A+  GH   ++L
Sbjct: 7   WETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRL 66

Query: 483 LLKQNVDVEAEDKDGDRAVHHAAFGDEGA----------VIEVLHRGSADLNARNKRRQT 532
           LL+    V+ ED  G        FG              ++++L    A ++  +K   T
Sbjct: 67  LLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLT 126

Query: 533 PLHIAVNKGHLQVVKTLLDFGCHPSLQ--DSEGDTPLHDAISKKRDDILAVLLEAGADVT 590
            LH A  KGH+ V+  +++     +L   D  G T  H A    + D L  L+ +G D  
Sbjct: 127 LLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN 186

Query: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650
           + +  G  ALH AA RG+   M VL   +     ++E+  +G TALH AA  +H +  +L
Sbjct: 187 VKDKEGNTALHLAAGRGH---MAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243

Query: 651 LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHH 710
           L+  G+    +   N  + LH A       + R+L+ AG   ++ D  G +PLH A+RH+
Sbjct: 244 LLRAGSTVNALTQKNL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302

Query: 711 TLSQLRQL-QDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769
             + +R L     DV  VD   +   +          A + +   IA  L   G DL++R
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHL---------AAEHAWQDIADMLLIAGVDLNLR 353

Query: 770 NKKGQSPL 777
           +K+G++ L
Sbjct: 354 DKQGKTAL 361



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 52/189 (27%), Positives = 98/189 (51%), Gaps = 3/189 (1%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G+TA+  A+  GH+ +L+ L+   +D+E ++ +G  A+H AA G     +++L R  + +
Sbjct: 192 GNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           NA  ++  + LH A   G   V + L+  G   ++ D +G +PLH A+      ++ +L+
Sbjct: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
            + +DV   +N     LH AA         +LL       + D++   G TAL +A  +N
Sbjct: 312 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ---GKTALAVAVRSN 368

Query: 644 HVEVAELLV 652
           HV + ++++
Sbjct: 369 HVSLVDMII 377



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 59/202 (29%), Positives = 93/202 (46%), Gaps = 5/202 (2%)

Query: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDV 490
           N  L  AA  G +A ++ L+    +D+  Q A G TA+ +A+   H D ++LLL+    V
Sbjct: 193 NTALHLAAGRGHMAVLQRLVDI-GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251

Query: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
            A  +     +H+AA      V  VL       N  + +  +PLH+AV      +V+ L+
Sbjct: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311

Query: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
           +     +  D+   TPLH A      DI  +LL AG D+ + +  G  AL   A+R N  
Sbjct: 312 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTAL-AVAVRSNHV 370

Query: 611 AMRVLLSKLPR--PWIVDEKKD 630
           ++  ++ K  R   W  D   D
Sbjct: 371 SLVDMIIKADRFYRWEKDHPSD 392



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 50/190 (26%), Positives = 82/190 (43%), Gaps = 20/190 (10%)

Query: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659
           LH AA + N   M+ L+ +         +   G  ALH AA   H +   LL+    A  
Sbjct: 19  LHEAARQNNVGRMQELIGRRVN---TRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75

Query: 660 DIQNVNQQT---------ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH-EALRH 709
           +   V   T         AL L+    H +I+++LV +GAK+  + KDG T LH  A + 
Sbjct: 76  EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135

Query: 710 HTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769
           H       ++D++DV  +D   +  +           A +        FL  +G D +++
Sbjct: 136 HVPVLAFIMEDLEDVA-LDHVDKLGRTAF------HRAAEHGQLDALDFLVGSGCDHNVK 188

Query: 770 NKKGQSPLDL 779
           +K+G + L L
Sbjct: 189 DKEGNTALHL 198


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  124 bits (311), Expect = 4e-28
 Identities = 123/442 (27%), Positives = 197/442 (44%), Gaps = 46/442 (10%)

Query: 406 AISNASGERLSQLLKKLFETQESGDLNEE-------LVKAAANGDVAKVE---DLLKRPD 455
           A+++ S E +  L+K       S D+N         L  AAAN  V   E    LL   +
Sbjct: 56  AVASRSEEAVQVLIK------HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109

Query: 456 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEV 515
           V   G   G TA+  A+ NGHV+++ LLL +  ++ A DK   RA+H AA+     V+ +
Sbjct: 110 VSDRG---GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166

Query: 516 LHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR 575
           L    A++  ++K+  TPLH A + G + VVK LL+ G      +  G+T LH A    +
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226

Query: 576 DDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTA 635
           D ++  L++ GA+V   NNNGF  LH AA   + +    LL  +     V+ +  DG + 
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL--VNNGADVNIQSKDGKSP 284

Query: 636 LHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQ 695
           LH+ A++     ++ L+  G   +D  + +  T LH+A    H  ++  L  +GA     
Sbjct: 285 LHMTAVHGRFTRSQTLIQNG-GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKC 343

Query: 696 DKDGDTPLH-EALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAAS 754
                 PLH  AL  H+    + L    ++   D       +    G            +
Sbjct: 344 GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG-----------GN 392

Query: 755 IAC--FLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISND 812
           + C   L ++GAD   ++K G++PL          A A CH   +   V + +    ++D
Sbjct: 393 VECIKLLQSSGADFHKKDKCGRTPLHY--------AAANCHFHCIETLVTTGANVNETDD 444

Query: 813 -SETLEECMVCSDMKRD-TLFG 832
              T       SDM R+ T+ G
Sbjct: 445 WGRTALHYAAASDMDRNKTILG 466



 Score =  116 bits (291), Expect = 9e-26
 Identities = 92/297 (30%), Positives = 140/297 (47%), Gaps = 40/297 (13%)

Query: 466 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 525
           T +  A+  G  +I++LL+     V A+D      +H A        ++VL + SAD+NA
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 526 RNKRRQTPLHI-AVNK--------------------------------GHLQVVKTLLDF 552
           R+K  QTPLH+ A NK                                GH+++V  LL  
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 553 GCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAM 612
           G + +  D +    LH A      D++A+L+  GA+VT  +  G+  LH AA  G  + +
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197

Query: 613 RVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHL 672
           + LL+       +DE    G TALH+A  N    V   L+  G AN++  N N  T LH 
Sbjct: 198 KHLLNLGVE---IDEINVYGNTALHIACYNGQDAVVNELIDYG-ANVNQPNNNGFTPLHF 253

Query: 673 AVERQHTQI-VRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVD 728
           A    H  + + LLV  GA ++IQ KDG +PLH    H   ++ + L  +Q+ G++D
Sbjct: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL--IQNGGEID 308



 Score =  116 bits (290), Expect = 1e-25
 Identities = 89/297 (29%), Positives = 140/297 (47%), Gaps = 39/297 (13%)

Query: 461 QCAGHTA--MQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR 518
           +C  H+   +  A+ N H D  + LL    +++  DK G   +H AA G     I++L  
Sbjct: 342 KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDD- 577
             AD + ++K  +TPLH A    H   ++TL+  G + +  D  G T LH A +   D  
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRN 461

Query: 578 ---------------------------ILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
                                       L  LL+  A+ +I +  G+N++H+AA  G+  
Sbjct: 462 KTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQ 521

Query: 611 AMRVLLSKLPRPWIVDEKKDDGYT--ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQT 668
            + +LL +    +   E+ D G T   LHLAA N H +  E+L+ Q   +LDI++   +T
Sbjct: 522 CLELLLERTNSGF---EESDSGATKSPLHLAAYNGHHQALEVLL-QSLVDLDIRDEKGRT 577

Query: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDK-DGDTPLH-EALRHHTLSQLRQLQDMQD 723
           AL LA  + HT+ V  L+  GA + ++D     TPLH   +  HTL  LR L ++ D
Sbjct: 578 ALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLC-LRLLLEIAD 633



 Score =  113 bits (283), Expect = 8e-25
 Identities = 95/333 (28%), Positives = 151/333 (45%), Gaps = 27/333 (8%)

Query: 482 LLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKG 541
           +L+ +  DV   D +    +H AAF  +  +IE+L    A +NA++    TPLH AV   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 542 HLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALH 601
             + V+ L+      + +D    TPLH A + K      V++   + V +++  G  ALH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 602 HAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDI 661
           HAAL G+   + +LL+K       D+K      ALH AA   H++V  LL++ G A +  
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKK---DRRALHWAAYMGHLDVVALLINHG-AEVTC 176

Query: 662 QNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDM 721
           ++    T LH A       +V+ L+  G ++D  +  G+T LH A  +   + + +L D 
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID- 235

Query: 722 QDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCP 781
                  A      N     L    A    A  +   L  NGAD++I++K G+SPL    
Sbjct: 236 -----YGANVNQPNNNGFTPLHFAAASTHGALCLE-LLVNNGADVNIQSKDGKSPL---- 285

Query: 782 DPNLCKALAKCHKEKVSGQVGSRSPSMISNDSE 814
                      H   V G+  +RS ++I N  E
Sbjct: 286 -----------HMTAVHGRF-TRSQTLIQNGGE 306



 Score =  108 bits (271), Expect = 2e-23
 Identities = 110/399 (27%), Positives = 175/399 (43%), Gaps = 22/399 (5%)

Query: 393 NPAAVSKVASAGSAISNASGER--LSQLLKKL---FETQESGDLNEELVKAAANGDVAKV 447
           NP+   K        + A G R  L  LL++    FE  +SG     L  AA NG    +
Sbjct: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558

Query: 448 EDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF 506
           E LL+   D+D+  +  G TA+  A+  GH + ++ L+     +  +D    R   HA+ 
Sbjct: 559 EVLLQSLVDLDIRDE-KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617

Query: 507 GDEGAVIEVLHRGSAD----LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562
            +   +   L    AD    ++ ++ + QTPL +AV  GH+  V  LL+   +    D  
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 677

Query: 563 GDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRP 622
           G T LH  I    ++ + +LLE    +   ++ G   LH+AA RG+ + +  LL      
Sbjct: 678 GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE 737

Query: 623 WIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV 682
                K + GYT LH A  N +    E+L+ Q      I   N  T LH A+   H    
Sbjct: 738 EDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG--NPFTPLHCAIINDHGNCA 795

Query: 683 RLLVRA--GAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIM 740
            LL+ A   + +  +D  G TPL  A     +  L+ L  ++    V+A     K  L+M
Sbjct: 796 SLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLL--LRHSAPVNAVDNSGKTALMM 853

Query: 741 GLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
                 AE   A ++   + +  ADL++++K   +PL L
Sbjct: 854 -----AAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887



 Score =  102 bits (255), Expect = 1e-21
 Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 9/273 (3%)

Query: 456 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEV 515
           VDV     G T +  A   GH+D + LLL++  +V+  D  G  A+H          +++
Sbjct: 638 VDVK-DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQM 696

Query: 516 LHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS---LQDSEGDTPLHDAIS 572
           L      +  ++ R +TPLH A  +GH   +  LL           +D++G TPLH A  
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACY 756

Query: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG 632
              ++ + VLLE         N  F  LH A +  + +   +LL  +    IV  + D G
Sbjct: 757 NGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSS-IVSCRDDKG 814

Query: 633 YTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVR-AGAK 691
            T L  AA  +HVE  +LL+   +A ++  + + +TAL +A E      V +LV  A A 
Sbjct: 815 RTPLRAAAFADHVECLQLLLRH-SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873

Query: 692 LDIQDKDGDTPLHEAL-RHHTLSQLRQLQDMQD 723
           L ++DKD +TPLH A  + H    L  L  +QD
Sbjct: 874 LTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 40/170 (23%), Positives = 80/170 (47%), Gaps = 4/170 (2%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG--SA 521
           G+T +  A  NG+ + +++LL+Q         +    +H A   D G    +L     S+
Sbjct: 747 GYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSS 805

Query: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
            ++ R+ + +TPL  A    H++ ++ LL      +  D+ G T L  A    +   + +
Sbjct: 806 IVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI 865

Query: 582 LLE-AGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKD 630
           L+  A AD+T+ + +    LH A  +G+     ++L K+    +++EK +
Sbjct: 866 LVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  122 bits (307), Expect = 1e-27
 Identities = 118/380 (31%), Positives = 174/380 (45%), Gaps = 48/380 (12%)

Query: 435 LVKAAANGDVAKVEDLL-KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           LV+A  + DV +V  LL ++ +++V  Q    T + AA+  G V IL+LLL    +V A+
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQ-ERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHI----------------- 536
           D      +H AA      V+ +L   SAD+NAR+K  QTPLH+                 
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 537 ----------------AVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 580
                           AV+ GHL+ V  LL+ G   ++ D +   PLH A      ++L 
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 581 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA 640
           +L+  GAD+   +  G+  LH AA  G    ++ LL        +DE    G TALH+A 
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE---IDEPNAFGNTALHIAC 247

Query: 641 LNNHVEVAELLVHQGNANLDIQNVNQQTALHL-AVERQHTQIVRLLVRAGAKLDIQDKDG 699
                 VA  LV+ G AN++  N    T LH+ AV       + LLV  GA ++ Q K+G
Sbjct: 248 YLGQDAVAIELVNAG-ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306

Query: 700 DTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFL 759
            +PLH A  H   ++ + L  +Q+  ++D A +   NT +      G E      +   L
Sbjct: 307 KSPLHMAAIHGRFTRSQIL--IQNGSEIDCA-DKFGNTPLHVAARYGHE-----LLISTL 358

Query: 760 AANGADLSIRNKKGQSPLDL 779
             NGAD + R      PL L
Sbjct: 359 MTNGADTARRGIHDMFPLHL 378



 Score =  108 bits (270), Expect = 3e-23
 Identities = 81/258 (31%), Positives = 123/258 (47%), Gaps = 8/258 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T + AA+  G+V+ L LLL    D+   DK G   +H+AA          L    A +
Sbjct: 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV 482

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  + +  +PLH A      +  +        PS  D+E D PL ++  K+    L  LL
Sbjct: 483 NEADCKGCSPLHYAAASDTYRRAEPHT-----PSSHDAEEDEPLKESRRKEAFFCLEFLL 537

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643
           + GAD ++ +  G+ A+H+AA  GN   + +LL ++    + D +     + LHLAA N 
Sbjct: 538 DNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL-EMSFNCLEDVESTIPVSPLHLAAYNG 596

Query: 644 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD-TP 702
           H E  + L  +   NLD+++   +TAL LA ER  T+ V +L   GA   I+++    TP
Sbjct: 597 HCEALKTLA-ETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTP 655

Query: 703 LHEALRHHTLSQLRQLQD 720
           LH A        L  L D
Sbjct: 656 LHAAAASGHTDSLHLLID 673



 Score =  107 bits (267), Expect = 6e-23
 Identities = 87/326 (26%), Positives = 154/326 (47%), Gaps = 15/326 (4%)

Query: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
           +G +A+  A  +GH++ + LLL +   +   DK   + +H AAF     V+++L    AD
Sbjct: 139 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198

Query: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582
           L  ++++    LH A   G ++VVK LL  G      ++ G+T LH A    +D +   L
Sbjct: 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIEL 258

Query: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
           + AGA+V   N+ GF  LH AA+  N +    LL  +     V+ +  +G + LH+AA++
Sbjct: 259 VNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL--VNNGADVNYQSKEGKSPLHMAAIH 316

Query: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
                +++L+  G + +D  +    T LH+A    H  ++  L+  GA    +      P
Sbjct: 317 GRFTRSQILIQNG-SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFP 375

Query: 703 LHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEK---------KSAA 753
           LH A+        R+L     +  + ++   +++ L  G      +           S  
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLS-NEHVLSAGFDINTPDNLGRTCLHAAASGG 434

Query: 754 SIAC--FLAANGADLSIRNKKGQSPL 777
           ++ C   L ++GADL  R+K G++PL
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPL 460



 Score =  102 bits (254), Expect = 2e-21
 Identities = 100/352 (28%), Positives = 148/352 (42%), Gaps = 30/352 (8%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AAA+G +  V+ LL+           G+TA+  A   G   +   L+    +V   +  G
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272

Query: 498 DRAVHHAAFGDEGAV-IEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP 556
              +H AA    GA+ +E+L    AD+N ++K  ++PLH+A   G     + L+  G   
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332

Query: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
              D  G+TPLH A     + +++ L+  GAD      +    LH A L G     R LL
Sbjct: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392

Query: 617 SKLPRPWIVDEKKDD---------------GYTALHLAALNNHVEVAELLVHQGNANLDI 661
           S      IV    ++               G T LH AA   +VE   LL+  G A+L  
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG-ADLRR 451

Query: 662 QNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDM 721
           ++   +T LH A      Q    LV AGA ++  D  G +PLH A    T  +       
Sbjct: 452 RDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPS 511

Query: 722 QDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
               + D   EP K +           +K A     FL  NGAD S+R+++G
Sbjct: 512 SHDAEED---EPLKES----------RRKEAFFCLEFLLDNGADPSLRDRQG 550



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 92/325 (28%), Positives = 139/325 (42%), Gaps = 47/325 (14%)

Query: 438 AAANGDVAKVEDLL---KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
           AAA+G    +  L+   +R D+       G T +  A  NGHVD + LLL++    +A D
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 718

Query: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL---- 550
             G  A+H  A       +  L    A +  R+ + +TP+H+A   GH  V++TLL    
Sbjct: 719 LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAAL 778

Query: 551 -----DFGC-------------------------HPSLQDSEGD--TPLHDAISKKRDDI 578
                D G                          H      EG+  TPLH A+   +D  
Sbjct: 779 STDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDST 838

Query: 579 LAVLLEA-GADVTITNN-NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTAL 636
             +LL A GA +  + +  G   LH AA   N S +R+LL        V+     G TAL
Sbjct: 839 TEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE---VNATDHTGRTAL 895

Query: 637 HLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQD 696
             AA N      E L+++G A+L + + N+ TALHLA  + H +   +++     L + +
Sbjct: 896 MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955

Query: 697 KDGDT---PLHEALRHHTLSQLRQL 718
                   PLH A R+   S ++ L
Sbjct: 956 ATNSALQMPLHIAARNGLASVVQAL 980



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 94/352 (26%), Positives = 144/352 (40%), Gaps = 49/352 (13%)

Query: 468 MQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH-RGSADLNAR 526
           +  A+ NGH + LK L +  V+++  D  G  A+  A        +EVL   G++ L   
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 527 NKRRQTPLH------------------------------------IAVNKGHLQVVKTLL 550
            KR+ TPLH                                    +A+  GH+  V  LL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708

Query: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
           + G      D  G T LH       +D LA LL+  A V   +  G   +H A+  G+ +
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 611 AMRVLLSKLPRPWIVDEKKD-DGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTA 669
            +R LL        +D   D  GY+ +H A+   H +  ELL+   ++       N  T 
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE--HSPFSYLEGNPFTP 826

Query: 670 LHLAVERQHTQIVRLLVRA-GAKL-DIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKV 727
           LH AV         +L+ A GAK+ + +D  G TPLH A     +S LR L  +Q   +V
Sbjct: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRML--LQHQAEV 884

Query: 728 DAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
           +A     +  L+       AE    A++   L    ADL++ ++   + L L
Sbjct: 885 NATDHTGRTALM-----TAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 79/272 (29%), Positives = 124/272 (45%), Gaps = 29/272 (10%)

Query: 531 QTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVT 590
           Q PL  A+    ++ V++LL    + ++ D E  TPLH A       IL +LL +GA+V 
Sbjct: 9   QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68

Query: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650
             +      LH AA   N   + +LL+       V+ +     T LH+AA N   + AE 
Sbjct: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSAD---VNARDKLWQTPLHVAAANRATKCAEA 125

Query: 651 LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHH 710
           L     ++L++ + + ++ALH AV   H + V LL+  GA L++ DK    PLH A    
Sbjct: 126 LAPL-LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184

Query: 711 TLSQLRQL---------QDMQDVGKVDAAWEPSKNTLIMGLGTQGAE-------KKSAAS 754
            L  L+ L         +D +  G +  A    +  ++  L   GAE         +A  
Sbjct: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244

Query: 755 IACFLAAN---------GADLSIRNKKGQSPL 777
           IAC+L  +         GA+++  N KG +PL
Sbjct: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 90/310 (29%), Positives = 136/310 (43%), Gaps = 20/310 (6%)

Query: 406 AISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-DVDVNGQCA- 463
           AI N   + +  LL+K   T ++ DL      A   G V   ED L    D D    C  
Sbjct: 695 AIMNGHVDCVHLLLEK-GSTADAADLRGRT--ALHRGAVTGCEDCLAALLDHDAFVLCRD 751

Query: 464 --GHTAMQAASQNGHVDILKLLLKQNVDVE----AEDKDGDRAVHHAAFGDEGAVIEVLH 517
             G T +  AS  GH  +L+ LL+  +  +      D  G   +H A++      +E+L 
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL 811

Query: 518 RGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD-FGCH-PSLQDSEGDTPLHDAISKKR 575
             S   +       TPLH AV        + LL   G    + +D++G TPLH A     
Sbjct: 812 EHSP-FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADN 870

Query: 576 DDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPW-IVDEKKDDGYT 634
              L +LL+  A+V  T++ G  AL  AA  G  +A+  LL +      ++DE K+   T
Sbjct: 871 VSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN---T 927

Query: 635 ALHLAALNNHVEVAELLVH--QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKL 692
           ALHLA    H + A +++   Q    ++  N   Q  LH+A       +V+ L+  GA +
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987

Query: 693 DIQDKDGDTP 702
              D++G TP
Sbjct: 988 LAVDEEGHTP 997



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 64/256 (25%), Positives = 112/256 (43%), Gaps = 8/256 (3%)

Query: 438  AAANGDVAKVEDLLKRP----DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            A+A G  A +  LL+       +D     +G++ M  AS  GH D L+LLL+ +     E
Sbjct: 761  ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLE 820

Query: 494  DKDGDRAVHHAAFGDEGAVIEVL--HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
                   +H A   ++ +  E+L    G+  +N+R+ + +TPLH A    ++  ++ LL 
Sbjct: 821  GNPFT-PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQ 879

Query: 552  FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAG-ADVTITNNNGFNALHHAALRGNPS 610
                 +  D  G T L  A    +   +  LL  G AD+T+ + N   ALH A  +G+  
Sbjct: 880  HQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEK 939

Query: 611  AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTAL 670
               ++L++     +++         LH+AA N    V + L+  G   L +       AL
Sbjct: 940  CALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPAL 999

Query: 671  HLAVERQHTQIVRLLV 686
              A  +     + L++
Sbjct: 1000 ACAPNKDVADCLALIL 1015



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 24/127 (18%)

Query: 659 LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLR-Q 717
           + I ++  Q  L  A+  +  + VR L+     +++ D++  TPLH A     +  L+  
Sbjct: 1   MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60

Query: 718 LQDMQDVGKVDAAW-------EPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRN 770
           L    +V   D  W         S+N  ++GL                L A+ AD++ R+
Sbjct: 61  LMSGANVNAKDTLWLTPLHRAAASRNEKVLGL----------------LLAHSADVNARD 104

Query: 771 KKGQSPL 777
           K  Q+PL
Sbjct: 105 KLWQTPL 111


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  122 bits (307), Expect = 1e-27
 Identities = 128/477 (26%), Positives = 206/477 (43%), Gaps = 89/477 (18%)

Query: 352 QRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG--------TSWTYNPAAVSKVASA 403
           ++ H +  E ++    KV  +  +   S  +   CG         S+  +P  +S     
Sbjct: 409 EKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT 468

Query: 404 GSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDV---DVNG 460
              + N   E + QLL++      S + + +L++AA  GDV  V+ L     V   D+ G
Sbjct: 469 ALQMGN---ENVQQLLQEGISLGNS-EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEG 524

Query: 461 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS 520
           + +  T +  A+    V +++ LL+   DV A+DK G   +H+A       V E+L +  
Sbjct: 525 RQS--TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 521 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 580
           A +N  +  + TPLH A  KG  ++ K LL  G  P+ ++ +G+TPL D +     DI  
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQD 641

Query: 581 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGY--TALHL 638
           +L             G  AL  AA +G  + ++    KL  P  V+ +   G   T LHL
Sbjct: 642 LL------------RGDAALLDAAKKGCLARVK----KLSSPDNVNCRDTQGRHSTPLHL 685

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA  N++EVAE L+  G A+++ Q+      LH A    H  +  LL++  A ++  DK 
Sbjct: 686 AAGYNNLEVAEYLLQHG-ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744

Query: 699 GDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACF 758
             TPLHEA +                                         K    +   
Sbjct: 745 AFTPLHEAAQ-----------------------------------------KGRTQLCAL 763

Query: 759 LAANGADLSIRNKKGQSPLDLCPDPNLC---------KALAKCHKEKVSGQVGSRSP 806
           L A+GAD +++N++GQ+PLDL    ++           AL  C+K +V    G RSP
Sbjct: 764 LLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLN--GVRSP 818



 Score =  119 bits (297), Expect = 2e-26
 Identities = 109/396 (27%), Positives = 169/396 (42%), Gaps = 77/396 (19%)

Query: 399 KVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDV 458
           + A  G+A ++A+ E +    ++LFE             A  NGDV +V+ L+    V+ 
Sbjct: 5   RCAGGGAACASAAAEAVEPAARELFE-------------ACRNGDVERVKRLVTPEKVN- 50

Query: 459 NGQCAGH--TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVL 516
           +   AG   T +  A+  G  D+++ LL+   +V+A D  G   +H+A       V+ +L
Sbjct: 51  SRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLL 110

Query: 517 HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRD 576
            R  AD NAR+    TPLH A  KG + V   LL  G  P++++++G T L         
Sbjct: 111 LRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALD-------- 162

Query: 577 DILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG--YT 634
                L +  A   +T     + L  +A  GN   M  LL+    P  V+    DG   T
Sbjct: 163 -----LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT----PLNVNCHASDGRKST 213

Query: 635 ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDI 694
            LHLAA  N V++ +LL+  G A++  ++      LH A    H ++  LLV+ GA ++ 
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHG-ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA 272

Query: 695 QDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAAS 754
            D    TPLHE                                         A  K+   
Sbjct: 273 MDLWQFTPLHE-----------------------------------------AASKNRVE 291

Query: 755 IACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALA 790
           +   L + GAD ++ N   +S +DL P P L + LA
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLA 327



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 76/270 (28%), Positives = 131/270 (48%), Gaps = 22/270 (8%)

Query: 458 VNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH 517
           + G+      +++A       ++ LL   NV+  A D      +H AA  +   ++++L 
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231

Query: 518 RGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDD 577
           +  AD++A++K    PLH A + GH +V + L+  G   +  D    TPLH+A SK R +
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291

Query: 578 ILAVLLEAGADVTITNNNGFNALH-----------------HAALRGNPSAMRVLLSKLP 620
           + ++LL  GAD T+ N +  +A+                  H+ L+    A    + K  
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351

Query: 621 RPWIVDEKKDDGY-TALHLAALN---NHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
              +V+ K    + TALH AA +      ++ ELL+ +G AN++ +     T LH+A E+
Sbjct: 352 SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG-ANINEKTKEFLTPLHVASEK 410

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
            H  +V ++V+  AK++  D  G T LH A
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 104/406 (25%), Positives = 169/406 (41%), Gaps = 65/406 (16%)

Query: 382 KVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAAN 441
           +VEVC    +Y            SAI  A   +L + L   F+          L++AA  
Sbjct: 289 RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK-------GHSLLQAARE 341

Query: 442 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHV---DILKLLLKQNVDVEAEDKDGD 498
            DV +++  L    V+        TA+  A+ + +     I +LLL++  ++  + K+  
Sbjct: 342 ADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFL 401

Query: 499 RAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSL 558
             +H A+      V+EV+ +  A +NA +   QT LH A   GHLQ  + LL +GC P++
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461

Query: 559 QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
              +G T    A+    +++  +L E    +++ N+     L  AA  G+   ++    K
Sbjct: 462 ISLQGFT----ALQMGNENVQQLLQEG---ISLGNSEADRQLLEAAKAGDVETVK----K 510

Query: 619 LPRPWIVDEKKDDG--YTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
           L     V+ +  +G   T LH AA  N V V E L+  G A++  ++      LH A   
Sbjct: 511 LCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG-ADVHAKDKGGLVPLHNACSY 569

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKN 736
            H ++  LLV+ GA +++ D    TPLHE                               
Sbjct: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHE------------------------------- 598

Query: 737 TLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPD 782
                     A  K    I   L  +GAD + +N+ G +PLDL  D
Sbjct: 599 ----------AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD 634


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  121 bits (304), Expect = 3e-27
 Identities = 116/391 (29%), Positives = 178/391 (45%), Gaps = 31/391 (7%)

Query: 403 AGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC 462
           AGS  +N+     S            G    E  +AA     A +      P   V    
Sbjct: 121 AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS 180

Query: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA--VHHAAFGDEGAVIEVLHRGS 520
                +  A +NG V  +K L+    +V A+D  G ++  +H AA      V+E L +  
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239

Query: 521 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 580
           A+++AR+     PLH A + GH +VV  LL  G  P+ +D+   TPLH+A  K + D+  
Sbjct: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCI 299

Query: 581 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA 640
           VLL+ GAD  I N +G +AL  A    +PSA  VL          + KKD+    L  AA
Sbjct: 300 VLLQHGADPNIRNTDGKSALDLA----DPSAKAVLTG--------EYKKDE----LLEAA 343

Query: 641 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700
            + + E    L+   N N    +  + T LHLA      +IV+LL++ GA +  +DK G 
Sbjct: 344 RSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 701 TPLHEALR--HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACF 758
            PLH A    H+ +++L  L+    V  +D  W+ +            A  K+   +   
Sbjct: 404 VPLHNACSYGHYEVTEL-LLKHGACVNAMD-LWQFTP--------LHEAASKNRVEVCSL 453

Query: 759 LAANGADLSIRNKKGQSPLDLCPDPNLCKAL 789
           L ++GAD ++ N  G+S +D+ P P L + L
Sbjct: 454 LLSHGADPTLVNCHGKSAVDMAPTPELRERL 484



 Score =  117 bits (292), Expect = 7e-26
 Identities = 122/451 (27%), Positives = 192/451 (42%), Gaps = 75/451 (16%)

Query: 398  SKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVD 457
            S ++  G   +    E + Q+L +    + S D++  L++A+  GD+  V+ L    +V+
Sbjct: 618  SIISLQGFTAAQMGNEAVQQILSESTPIRTS-DVDYRLLEASKAGDLETVKQLCSSQNVN 676

Query: 458  VNGQCAGH-TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVL 516
                   H T +  A+    V +++ LL    DV A+DK G   +H+A       V E+L
Sbjct: 677  CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELL 736

Query: 517  HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRD 576
             R  A +N  +  + TPLH A  KG  ++ K LL  G  P+ ++ +G+TPL D + +   
Sbjct: 737  VRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDT 795

Query: 577  DILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTAL 636
            DI  +L             G  AL  AA +G  + ++ L +  P      + +    T L
Sbjct: 796  DIQDLL------------RGDAALLDAAKKGCLARVQKLCT--PENINCRDTQGRNSTPL 841

Query: 637  HLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQD 696
            HLAA  N++EVAE L+  G A+++ Q+      LH A    H  I  LL++    ++  D
Sbjct: 842  HLAAGYNNLEVAEYLLEHG-ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900

Query: 697  KDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIA 756
            K   TPLHE                                         A +K    + 
Sbjct: 901  KWAFTPLHE-----------------------------------------AAQKGRTQLC 919

Query: 757  CFLAANGADLSIRNKKGQSPLDLCP---------DPNLCKALAKCHKEKVSGQVGSRSPS 807
              L A+GAD +++N++GQ+PLDL           D    +AL  C K     Q    S S
Sbjct: 920  ALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKP----QATVVSAS 975

Query: 808  MISNDSETLEECMVCSDMKRDTLFGPCGHIA 838
            +IS  S     C+  +    D L GP   +A
Sbjct: 976  LISPAS--TPSCLSAAS-SIDNLTGPLAELA 1003



 Score =  114 bits (284), Expect = 6e-25
 Identities = 82/270 (30%), Positives = 135/270 (50%), Gaps = 22/270 (8%)

Query: 458 VNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH 517
           + G+      ++AA       ++ LL   NV+  A D      +H AA  +   ++++L 
Sbjct: 330 LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLL 389

Query: 518 RGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDD 577
           +  AD++A++K    PLH A + GH +V + LL  G   +  D    TPLH+A SK R +
Sbjct: 390 QHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVE 449

Query: 578 ILAVLLEAGADVTITNNNGFNALH-----------------HAALRGNPSAMRVLLSKLP 620
           + ++LL  GAD T+ N +G +A+                  H+ L+    A    + K  
Sbjct: 450 VCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTL 509

Query: 621 RPWIVDEKKDDGY-TALHLAALNNH---VEVAELLVHQGNANLDIQNVNQQTALHLAVER 676
              I++ K+   + TALH A  + H    +V ELL+ +G AN++ +N +  T LH+A ER
Sbjct: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKG-ANVNEKNKDFMTPLHVAAER 568

Query: 677 QHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
            H  ++ +L + GAK++  D  G T LH A
Sbjct: 569 AHNDVMEVLHKHGAKMNALDTLGQTALHRA 598



 Score =  105 bits (263), Expect = 2e-22
 Identities = 121/447 (27%), Positives = 192/447 (42%), Gaps = 70/447 (15%)

Query: 382 KVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAAN 441
           +VEVC    ++            SA+  A    L + L   F+          L++AA  
Sbjct: 447 RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK-------GHSLLQAARE 499

Query: 442 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHV---DILKLLLKQNVDVEAEDKDGD 498
            D+AKV+  L    ++     +  TA+  A  + H     + +LLL++  +V  ++KD  
Sbjct: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559

Query: 499 RAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSL 558
             +H AA      V+EVLH+  A +NA +   QT LH A   GHLQ  + LL +G  PS+
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619

Query: 559 QDSEGDTP-----------LHDAISKKRDDILAVLLEA--------------GADVTITN 593
              +G T            L ++   +  D+   LLEA                +V   +
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRD 679

Query: 594 NNGFNA--LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
             G ++  LH AA     S +  LL        V  K   G   LH A    H EVAELL
Sbjct: 680 LEGRHSTPLHFAAGYNRVSVVEYLLH---HGADVHAKDKGGLVPLHNACSYGHYEVAELL 736

Query: 652 VHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHT 711
           V  G A++++ ++ + T LH A  +   +I +LL++ GA    +++DG+TPL       T
Sbjct: 737 VRHG-ASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 795

Query: 712 LSQLRQLQDMQDVGKVDAA-WEPSKNTLIMGL------------GTQG--------AEKK 750
                   D+QD+ + DAA  + +K   +  +             TQG        A   
Sbjct: 796 --------DIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 751 SAASIACFLAANGADLSIRNKKGQSPL 777
           +   +A +L  +GAD++ ++K G  PL
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPL 874


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  120 bits (302), Expect = 5e-27
 Identities = 96/321 (29%), Positives = 147/321 (45%), Gaps = 22/321 (6%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G   +  A+QNG     +LLL     V+A++++G   +H AA  +   V  +L    AD 
Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADP 487

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N      +TPLH+A   GH+ +VK L   G     Q     TPLH A+ + +   +  LL
Sbjct: 488 NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLL---SKLPRPWIVDEKKDDGYTALHLAA 640
           ++GA     + +G+  LH AA RG     ++LL   + L  P         G+T LHLAA
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP------THQGWTPLHLAA 601

Query: 641 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700
              H+E+  LL  + +AN+        T LHLA       +V  L++ GA  +  ++ G 
Sbjct: 602 YKGHLEIIHLLA-ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 701 TPLHEALRHHT-LSQLRQLQDMQDV-GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACF 758
           TPLH A++  T LS +  L+   +V  +    W P+            A  K   +I   
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA----------HLAALKGNTAILKV 710

Query: 759 LAANGADLSIRNKKGQSPLDL 779
           L   GA L +++    +PL L
Sbjct: 711 LVEAGAQLDVQDGVSCTPLQL 731



 Score =  119 bits (298), Expect = 1e-26
 Identities = 104/342 (30%), Positives = 160/342 (46%), Gaps = 16/342 (4%)

Query: 440 ANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGD 498
           A G V +V  LL   +VDV+ Q A G+T +  A+Q+   D+  LLL    D    D+DG 
Sbjct: 371 AQGSVEQVRLLLAH-EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429

Query: 499 RAVHHAAF-GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
             +H AA  GD+G    +L  G+  ++A+ +   TPLH+A       V + L+     P+
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
           L ++EG TPLH A       ++ +L   GA++     N    LH A  RG   A++ LL 
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
               P  +D+    GY  LH AA      + ++L+  G A+L++      T LHLA  + 
Sbjct: 549 SGAVPDALDQ---SGYGPLHTAAARGKYLICKMLLRYG-ASLELPTHQGWTPLHLAAYKG 604

Query: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNT 737
           H +I+ LL  + A +        TPLH A RH   + +  L  +Q     +AA +     
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL--LQCGADPNAAEQSGWTP 662

Query: 738 LIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDL 779
           L +      A ++S       L  + A++  RNK G +P  L
Sbjct: 663 LHL------AVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698



 Score =  118 bits (296), Expect = 2e-26
 Identities = 86/302 (28%), Positives = 142/302 (47%), Gaps = 33/302 (10%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AA NGD      LL         +  G T +  A+QN   ++ +LL+ +  D    + +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
              +H AA+    +++++L    A+L+A+ +  +TPLH+AV +G ++ ++ LL  G  P 
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
             D  G  PLH A ++ +  I  +LL  GA + +  + G+  LH AA +G+   + +L  
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614

Query: 618 KLPRPWIV------------------------------DEKKDDGYTALHLAALNN-HVE 646
                  +                              +  +  G+T LHLA   +  + 
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLS 674

Query: 647 VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706
           V  LL H  +AN+  +N    T  HLA  + +T I+++LV AGA+LD+QD    TPL  A
Sbjct: 675 VINLLEH--HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732

Query: 707 LR 708
           LR
Sbjct: 733 LR 734



 Score =  112 bits (280), Expect = 2e-24
 Identities = 83/253 (32%), Positives = 124/253 (49%), Gaps = 14/253 (5%)

Query: 528 KRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGA 587
           + + TPLH  V +G ++ V+ LL        Q + G TPL  A   ++ D+ A+LL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 588 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 647
           D    + +G+  LH AA  G+    R+LL        VD ++ +G+T LHLAA NN   V
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD---HGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 648 AELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEAL 707
           A LLV +  A+ ++     +T LH+A    H  +V+LL   GA+LD Q ++  TPLH A+
Sbjct: 477 ARLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535

Query: 708 RHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIAC-FLAANGADL 766
                 ++R +Q +   G V  A + S      G G           + C  L   GA L
Sbjct: 536 ER---GKVRAIQHLLKSGAVPDALDQS------GYGPLHTAAARGKYLICKMLLRYGASL 586

Query: 767 SIRNKKGQSPLDL 779
            +   +G +PL L
Sbjct: 587 ELPTHQGWTPLHL 599



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 58/187 (31%), Positives = 87/187 (46%)

Query: 430 DLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVD 489
           +L   L  A   G V  ++ LLK   V      +G+  +  A+  G   I K+LL+    
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585

Query: 490 VEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTL 549
           +E     G   +H AA+     +I +L    A++ A      TPLH+A   G   VV  L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 550 LDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNP 609
           L  G  P+  +  G TPLH A+ +     +  LLE  A+V   N  G+   H AAL+GN 
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNT 705

Query: 610 SAMRVLL 616
           + ++VL+
Sbjct: 706 AILKVLV 712



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 49/157 (31%), Positives = 72/157 (45%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A+  GH++I+ LL + + ++ A        +H AA   E AV+  L +  AD 
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           NA  +   TPLH+AV +     V  LL+   +   ++  G TP H A  K    IL VL+
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLP 620
           EAGA + + +      L  A        M  L  K P
Sbjct: 713 EAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEP 749



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 57/225 (25%), Positives = 88/225 (39%), Gaps = 45/225 (20%)

Query: 565 TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI 624
           TPLH  +++   + + +LL    DV     +G+  L  AA    P    +LL+       
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 625 VDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRL 684
           VDE   DG+  LH AA N     A LL+  G A +D Q     T LHLA +     + RL
Sbjct: 424 VDE---DGWAPLHFAAQNGDDGTARLLLDHG-ACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 685 LVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGT 744
           LV   A  ++ + +G TPLH A     +S ++                            
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK---------------------------- 511

Query: 745 QGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKAL 789
                         L + GA+L  + +  ++PL L  +    +A+
Sbjct: 512 -------------LLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  120 bits (301), Expect = 6e-27
 Identities = 105/368 (28%), Positives = 176/368 (47%), Gaps = 20/368 (5%)

Query: 415 LSQLLKKLFETQESGDLNEEL--VKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAA 471
           L+Q+L  +    E   +  ++  + AAANG   K+  LL     DVN Q + G+TA+  A
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341

Query: 472 SQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRR 530
              G+VD++K+LL+    +E  +++G   +  A       V  +L    A +N   N+ +
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401

Query: 531 QTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVT 590
           ++ L +A  KGHL++V+ LL+ G     +  E  T L +A      ++  +LL++GA V 
Sbjct: 402 ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461

Query: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650
           +  ++  + L  AA  G+     +L+    R   ++E  D+GYT L  AA   H E+  L
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIE---RGASLEEVNDEGYTPLMEAAREGHEEMVAL 518

Query: 651 LVHQGNANLDIQNVN-QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
           L+ QG AN++ Q    Q+TAL LA      ++   L++AGA +++      TPL EA + 
Sbjct: 519 LLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQE 574

Query: 710 HTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769
             L  ++ L        + A       T         A +     +A  L   GADL   
Sbjct: 575 GHLELVKYL--------LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626

Query: 770 NKKGQSPL 777
           ++ G++PL
Sbjct: 627 SEGGRTPL 634



 Score =  110 bits (276), Expect = 5e-24
 Identities = 91/291 (31%), Positives = 142/291 (48%), Gaps = 12/291 (4%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA  G V  VE LL    D++   +    T +  A   G  ++++LLL +  + E  
Sbjct: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR--NKRRQTPLHIAVNKGHLQVVKTLLD 551
            +      +  AA G    +I++L    A++N+R  +K   +PL +A   GH   VK LLD
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239

Query: 552  FGCHPSLQ-DSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G   + Q ++  +T L  A  + R +++++LL+  A+V      G   L  AA  G   
Sbjct: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299

Query: 611  AMRVLLSK---LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQ 667
              RVLL K   +  P +   +     TAL +AA   H +  ELL+ +G A++D++N    
Sbjct: 1300 VGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRG-AHIDVRNKKGN 1354

Query: 668  TALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
            T L LA    H  +V+LLV+AGA +D  D    TPL  A R   +  +R L
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405



 Score =  104 bits (260), Expect = 4e-22
 Identities = 95/325 (29%), Positives = 145/325 (44%), Gaps = 43/325 (13%)

Query: 455  DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIE 514
            D+D   +    TA+  A   GH ++++ LL++   +E  DK G   +  AA      V+E
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 515  VLHRGSADLNARNKR-RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
            +L    AD+ A+++R + TPL +A + G  +VV+ LL  G +   ++    TPL  A S 
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 574  KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGY 633
               +I+ +LL AGA++                           SKL            G 
Sbjct: 1194 GYVNIIKILLNAGAEINSRTG----------------------SKL------------GI 1219

Query: 634  TALHLAALNNHVEVAELLVHQGN-ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKL 692
            + L LAA+N H    +LL+  G+  N  I+  N+ TAL LA  +  T++V LL+   A +
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANV 1278

Query: 693  DIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSA 752
            + + K G TPL EA         R L D      V+A   PS     + +    A  K  
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKG--ADVNAPPVPSSRDTALTI----AADKGH 1332

Query: 753  ASIACFLAANGADLSIRNKKGQSPL 777
                  L   GA + +RNKKG +PL
Sbjct: 1333 YKFCELLIGRGAHIDVRNKKGNTPL 1357



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 75/253 (29%), Positives = 119/253 (47%), Gaps = 7/253 (2%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
           L  AA  G V     L++R          G+T +  A++ GH +++ LLL Q  ++ A+ 
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530

Query: 495 KDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL  G
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAG 587

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613
            +     + GDT L  A      D+  VLL+AGAD+   +  G   L  AA  G+   ++
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647

Query: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673
            L+SK     +     ++ +T L LA    H+ V ELL+  G A+   +  +  T L  A
Sbjct: 648 FLISKGAN--VNRTTANNDHTVLSLACAGGHLAVVELLLAHG-ADPTHRLKDGSTMLIEA 704

Query: 674 VERQHTQIVRLLV 686
            +  HT +V  L+
Sbjct: 705 AKGGHTSVVCYLL 717



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 60/188 (31%), Positives = 96/188 (51%), Gaps = 3/188 (1%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA NG  A V+ LL    D++   +   +TA+  A   G  +++ LLL +  +VE  
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARN--KRRQTPLHIAVNKGHLQVVKTLLD 551
             K G   +  AA G    V  VL    AD+NA      R T L IA +KGH +  + L+ 
Sbjct: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIG 1341

Query: 552  FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
             G H  +++ +G+TPL  A +    D++ +L++AGADV   +N     L  A  +G+   
Sbjct: 1342 RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV 1401

Query: 612  MRVLLSKL 619
            +R L+ ++
Sbjct: 1402 VRYLVKEV 1409



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 85/315 (26%), Positives = 141/315 (44%), Gaps = 22/315 (6%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD-T 565
           GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL    +   +  +GD T
Sbjct: 245 GDVNAVRKLLIEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303

Query: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
           PL  A +     I+ +LL   ADV   ++ G  AL +A   G    ++VLL        +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS---I 360

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           ++  ++G+T L  A    HVEVA LL+  G       N  +++AL LA  + H ++VR L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           + AGA  + +  +  T L EA     +   R L D      + A    S  TL       
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL------- 473

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRS 805
            A       +A  L   GA L   N +G +P        L +A  + H+E V+  +G + 
Sbjct: 474 -AACGGHVELAALLIERGASLEEVNDEGYTP--------LMEAAREGHEEMVALLLG-QG 523

Query: 806 PSMISNDSETLEECM 820
            ++ +   ET E  +
Sbjct: 524 ANINAQTEETQETAL 538



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/141 (29%), Positives = 71/141 (50%), Gaps = 3/141 (2%)

Query: 413  ERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQ---CAGHTAMQ 469
            E +S LL +    +         +  AA+G  A+V  +L     DVN      +  TA+ 
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 470  AASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529
             A+  GH    +LL+ +   ++  +K G+  +  AA G    V+++L +  AD++A + R
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 530  RQTPLHIAVNKGHLQVVKTLL 550
            + TPL  A  KGH++VV+ L+
Sbjct: 1386 KITPLMAAFRKGHVKVVRYLV 1406



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 46/152 (30%), Positives = 73/152 (48%), Gaps = 3/152 (1%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           L++AA  G +  V+ LL     +V+   A G TA+  A +NGH D+  +LL+   D+E E
Sbjct: 568 LMEAAQEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQ-TPLHIAVNKGHLQVVKTLLDF 552
            + G   +  AA       ++ L    A++N        T L +A   GHL VV+ LL  
Sbjct: 627 SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686

Query: 553 GCHPSLQDSEGDTPLHDAISKKRDDILAVLLE 584
           G  P+ +  +G T L +A       ++  LL+
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 41/130 (31%), Positives = 58/130 (44%), Gaps = 5/130 (3%)

Query: 425 TQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLL 483
           T  +GD    L  A  NG    V D+L +   D+  +   G T +  A++ GHV  ++ L
Sbjct: 593 TTATGDT--ALTYACENGHT-DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 484 LKQNVDVEAEDKDGDRAVHH-AAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGH 542
           + +  +V     + D  V   A  G   AV+E+L    AD   R K   T L  A   GH
Sbjct: 650 ISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 709

Query: 543 LQVVKTLLDF 552
             VV  LLD+
Sbjct: 710 TSVVCYLLDY 719



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 16/153 (10%)

Query: 665  NQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDV 724
            N  TAL LA    H ++V+ L+  GA ++ +DK G TPL  A    T   +  ++ + D 
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA---TAGHVGVVEILLDN 1138

Query: 725  G-KVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPD- 782
            G  ++A  E +K+T  + L   G  ++    +   L A GA+   RN    +PL L    
Sbjct: 1139 GADIEAQSERTKDT-PLSLACSGGRQE----VVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 783  --PNLCKALAKCHKEKVSGQVGSR---SPSMIS 810
               N+ K L     E ++ + GS+   SP M++
Sbjct: 1194 GYVNIIKILLNAGAE-INSRTGSKLGISPLMLA 1225


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  120 bits (301), Expect = 6e-27
 Identities = 105/368 (28%), Positives = 176/368 (47%), Gaps = 20/368 (5%)

Query: 415 LSQLLKKLFETQESGDLNEEL--VKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAA 471
           L+Q+L  +    E   +  ++  + AAANG   K+  LL     DVN Q + G+TA+  A
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341

Query: 472 SQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRR 530
              G+VD++K+LL+    +E  +++G   +  A       V  +L    A +N   N+ +
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401

Query: 531 QTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVT 590
           ++ L +A  KGHL++V+ LL+ G     +  E  T L +A      ++  +LL++GA V 
Sbjct: 402 ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461

Query: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650
           +  ++  + L  AA  G+     +L+    R   ++E  D+GYT L  AA   H E+  L
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIE---RGASLEEVNDEGYTPLMEAAREGHEEMVAL 518

Query: 651 LVHQGNANLDIQNVN-QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH 709
           L+ QG AN++ Q    Q+TAL LA      ++   L++AGA +++      TPL EA + 
Sbjct: 519 LLGQG-ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQE 574

Query: 710 HTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769
             L  ++ L        + A       T         A +     +A  L   GADL   
Sbjct: 575 GHLELVKYL--------LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626

Query: 770 NKKGQSPL 777
           ++ G++PL
Sbjct: 627 SEGGRTPL 634



 Score =  110 bits (276), Expect = 5e-24
 Identities = 91/291 (31%), Positives = 142/291 (48%), Gaps = 12/291 (4%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA  G V  VE LL    D++   +    T +  A   G  ++++LLL +  + E  
Sbjct: 869  LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 928

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR--NKRRQTPLHIAVNKGHLQVVKTLLD 551
            +      +  AA G    +I++L    A++N+R  +K   +PL +A   GH   VK LLD
Sbjct: 929  NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 988

Query: 552  FGCHPSLQ-DSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G   + Q ++  +T L  A  + R +++++LL+  A+V      G   L  AA  G   
Sbjct: 989  MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048

Query: 611  AMRVLLSK---LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQ 667
              RVLL K   +  P +   +     TAL +AA   H +  ELL+ +G A++D++N    
Sbjct: 1049 VGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRG-AHIDVRNKKGN 1103

Query: 668  TALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL 718
            T L LA    H  +V+LLV+AGA +D  D    TPL  A R   +  +R L
Sbjct: 1104 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1154



 Score =  104 bits (260), Expect = 4e-22
 Identities = 95/325 (29%), Positives = 145/325 (44%), Gaps = 43/325 (13%)

Query: 455  DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIE 514
            D+D   +    TA+  A   GH ++++ LL++   +E  DK G   +  AA      V+E
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882

Query: 515  VLHRGSADLNARNKR-RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
            +L    AD+ A+++R + TPL +A + G  +VV+ LL  G +   ++    TPL  A S 
Sbjct: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942

Query: 574  KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGY 633
               +I+ +LL AGA++                           SKL            G 
Sbjct: 943  GYVNIIKILLNAGAEINSRTG----------------------SKL------------GI 968

Query: 634  TALHLAALNNHVEVAELLVHQGN-ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKL 692
            + L LAA+N H    +LL+  G+  N  I+  N+ TAL LA  +  T++V LL+   A +
Sbjct: 969  SPLMLAAMNGHTAAVKLLLDMGSDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKANV 1027

Query: 693  DIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSA 752
            + + K G TPL EA         R L D      V+A   PS     + +    A  K  
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKG--ADVNAPPVPSSRDTALTI----AADKGH 1081

Query: 753  ASIACFLAANGADLSIRNKKGQSPL 777
                  L   GA + +RNKKG +PL
Sbjct: 1082 YKFCELLIGRGAHIDVRNKKGNTPL 1106



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 75/253 (29%), Positives = 119/253 (47%), Gaps = 7/253 (2%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
           L  AA  G V     L++R          G+T +  A++ GH +++ LLL Q  ++ A+ 
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530

Query: 495 KDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL  G
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAG 587

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613
            +     + GDT L  A      D+  VLL+AGAD+   +  G   L  AA  G+   ++
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647

Query: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673
            L+SK     +     ++ +T L LA    H+ V ELL+  G A+   +  +  T L  A
Sbjct: 648 FLISKGAN--VNRTTANNDHTVLSLACAGGHLAVVELLLAHG-ADPTHRLKDGSTMLIEA 704

Query: 674 VERQHTQIVRLLV 686
            +  HT +V  L+
Sbjct: 705 AKGGHTSVVCYLL 717



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 60/188 (31%), Positives = 96/188 (51%), Gaps = 3/188 (1%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA NG  A V+ LL    D++   +   +TA+  A   G  +++ LLL +  +VE  
Sbjct: 971  LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1030

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARN--KRRQTPLHIAVNKGHLQVVKTLLD 551
             K G   +  AA G    V  VL    AD+NA      R T L IA +KGH +  + L+ 
Sbjct: 1031 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIG 1090

Query: 552  FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
             G H  +++ +G+TPL  A +    D++ +L++AGADV   +N     L  A  +G+   
Sbjct: 1091 RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV 1150

Query: 612  MRVLLSKL 619
            +R L+ ++
Sbjct: 1151 VRYLVKEV 1158



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 85/315 (26%), Positives = 141/315 (44%), Gaps = 22/315 (6%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD-T 565
           GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL    +   +  +GD T
Sbjct: 245 GDVNAVRKLLIEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303

Query: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
           PL  A +     I+ +LL   ADV   ++ G  AL +A   G    ++VLL        +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS---I 360

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           ++  ++G+T L  A    HVEVA LL+  G       N  +++AL LA  + H ++VR L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           + AGA  + +  +  T L EA     +   R L D      + A    S  TL       
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL------- 473

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRS 805
            A       +A  L   GA L   N +G +P        L +A  + H+E V+  +G + 
Sbjct: 474 -AACGGHVELAALLIERGASLEEVNDEGYTP--------LMEAAREGHEEMVALLLG-QG 523

Query: 806 PSMISNDSETLEECM 820
            ++ +   ET E  +
Sbjct: 524 ANINAQTEETQETAL 538



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 107/418 (25%), Positives = 177/418 (42%), Gaps = 53/418 (12%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           L++AA  G +  V+ LL     +V+   A G TA+  A +NGH D+  +LL+   D+E E
Sbjct: 568 LMEAAQEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQ-TPLHIAVNKGHLQVVKTLLDF 552
            + G   +  AA       ++ L    A++N        T L +A   GHL VV+ LL  
Sbjct: 627 SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686

Query: 553 GCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAM 612
           G  P+ +  +G T L +A       ++  LL+   ++          L   +   N  A 
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLN-RAP 745

Query: 613 RVLLSKLPR---PWIVDEKKDDGYTALHL---------AALNNH---------------- 644
           RV +  LP    P   D+   +  T L +         +A++N                 
Sbjct: 746 RVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPT 805

Query: 645 ----VEVAELLVHQGNANLDIQ-NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDG 699
               +  + +L      ++D Q   N  TAL LA    H ++V+ L+  GA ++ +DK G
Sbjct: 806 PSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 865

Query: 700 DTPLHEALRHHTLSQLRQLQDMQDVG-KVDAAWEPSKNTLIMGLGTQGAEKKSAASIACF 758
            TPL  A    T   +  ++ + D G  ++A  E +K+T  + L   G  ++    +   
Sbjct: 866 FTPLILAA---TAGHVGVVEILLDNGADIEAQSERTKDT-PLSLACSGGRQE----VVEL 917

Query: 759 LAANGADLSIRNKKGQSPLDLCPD---PNLCKALAKCHKEKVSGQVGSR---SPSMIS 810
           L A GA+   RN    +PL L       N+ K L     E ++ + GS+   SP M++
Sbjct: 918 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE-INSRTGSKLGISPLMLA 974



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/141 (29%), Positives = 71/141 (50%), Gaps = 3/141 (2%)

Query: 413  ERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQ---CAGHTAMQ 469
            E +S LL +    +         +  AA+G  A+V  +L     DVN      +  TA+ 
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074

Query: 470  AASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529
             A+  GH    +LL+ +   ++  +K G+  +  AA G    V+++L +  AD++A + R
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134

Query: 530  RQTPLHIAVNKGHLQVVKTLL 550
            + TPL  A  KGH++VV+ L+
Sbjct: 1135 KITPLMAAFRKGHVKVVRYLV 1155


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  116 bits (291), Expect = 9e-26
 Identities = 104/366 (28%), Positives = 169/366 (46%), Gaps = 13/366 (3%)

Query: 415 LSQLLKKLFETQESGDLNEE-LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQ 473
           L  LL+K  +  E  +  +  L+ AA  G++  V++L+K             TA+ +AS+
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 474 NGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTP 533
            GHV I++ LLK  V++E  D  G  A+  A +     V+E+L    A+ +        P
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140

Query: 534 LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 593
           +  A  +GH  +V  LL  G   +  D  G TPL  A  K   + +  LL  GADV    
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200

Query: 594 NNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH 653
            N   AL  A   G   +++ +L + P   + D+   DG TAL +A+   H E+ + L+ 
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDK---DGNTALMIASKEGHTEIVQDLLD 257

Query: 654 QGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLS 713
            G   ++I + +  T L  AV   H +IVR L++  A +DI+ +D  T L+ A+     +
Sbjct: 258 AG-TYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316

Query: 714 QLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKG 773
            +R +  +Q     +   +  +  LI       A K     +   L   GA +S  +KKG
Sbjct: 317 MVRDI--LQCNPDTEICTKDGETPLIK------ATKMRNIEVVELLLDKGAKVSAVDKKG 368

Query: 774 QSPLDL 779
            +PL +
Sbjct: 369 DTPLHI 374



 Score =  101 bits (251), Expect = 4e-21
 Identities = 83/281 (29%), Positives = 139/281 (49%), Gaps = 13/281 (4%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCA---GHTAMQAASQNGHVDILKLLLKQNVDVE 491
           ++ AA  G  A +  LL +    VN  C+   G T +  A++ GH++ +K LL    DV+
Sbjct: 141 IIWAAGRGH-ADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197

Query: 492 AEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
            E  +   A+  A  G     ++ + + + ++N  +K   T L IA  +GH ++V+ LLD
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
            G + ++ D  GDT L  A+     +I+  LL+  AD+ I   +   AL+ A  +GN + 
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317

Query: 612 MRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALH 671
           +R +L   P   I  +   DG T L  A    ++EV ELL+ +G A +   +    T LH
Sbjct: 318 VRDILQCNPDTEICTK---DGETPLIKATKMRNIEVVELLLDKG-AKVSAVDKKGDTPLH 373

Query: 672 LAVERQHTQIVRLLVR---AGAKLDIQDKDGDTPLHEALRH 709
           +A+  +  ++  LL+R    G  L   +K G+TP +    H
Sbjct: 374 IAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSH 414



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 85/303 (28%), Positives = 147/303 (48%), Gaps = 14/303 (4%)

Query: 476 HVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLH 535
           ++  LK LL++  DV+  ++ G   +  AA      +++ L +  A+ N  +    T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 536 IAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNN 595
            A  +GH+ +V+ LL  G +   +D  G T L  A  K R D++ +LL  GA+ ++T   
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 596 GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQG 655
               +  AA RG+   + +LL    +   V+     G T L  AA   H+E  + L+  G
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAK---VNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 656 NANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH-HTLSQ 714
            A++D +  N  TAL +AV+  +TQ V+ +++    +++ DKDG+T L  A +  HT   
Sbjct: 194 -ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHT--- 249

Query: 715 LRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQ 774
              +QD+ D G      + S +T+++     GA +     I   L    AD+ IR +  +
Sbjct: 250 -EIVQDLLDAGTYVNIPDRSGDTVLI-----GAVRGGHVEIVRALLQKYADIDIRGQDNK 303

Query: 775 SPL 777
           + L
Sbjct: 304 TAL 306



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 70/267 (26%), Positives = 118/267 (44%), Gaps = 5/267 (1%)

Query: 435 LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
           LV AA  G +  V+ LL    DVD  G     TA+  A + G+   +K +LK+N +V   
Sbjct: 174 LVWAARKGHLECVKHLLAMGADVDQEG-ANSMTALIVAVKGGYTQSVKEILKRNPNVNLT 232

Query: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553
           DKDG+ A+  A+      +++ L      +N  ++   T L  AV  GH+++V+ LL   
Sbjct: 233 DKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKY 292

Query: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613
               ++  +  T L+ A+ K    ++  +L+   D  I   +G   L  A    N   + 
Sbjct: 293 ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVE 352

Query: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673
           +LL K  +   VD+K D   T LH+A      ++AELL+        +   N+       
Sbjct: 353 LLLDKGAKVSAVDKKGD---TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYN 409

Query: 674 VERQHTQIVRLLVRAGAKLDIQDKDGD 700
           ++  H + +   +     L   + DGD
Sbjct: 410 IDCSHQKSILTQIFGARHLSPTETDGD 436


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  114 bits (286), Expect = 4e-25
 Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 7/300 (2%)

Query: 402 SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL--KRPDVDVN 459
           S   A S+     + +LL +     E  +  E L+  A +    ++  +L     +V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 460 GQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG 519
           G     T + AAS  G++DI+KLLL  + DV ++   G+ A+ +A  G    +++VL   
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 520 SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE-GDTPLHDAISKKRDDI 578
            A++   N+   TPL  A + GH++V + LLD G   +   +E  ++ L  A  K   D+
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638
           +  LLEAGAD     +    AL  A + G+    R+LL    +   V+   D   + L L
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ---VNMPADSFESPLTL 444

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   HVE+A LL+ +G ANL+  N    T L  A    H ++V LL+  GA ++ Q ++
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503



 Score =  107 bits (266), Expect = 7e-23
 Identities = 104/382 (27%), Positives = 184/382 (48%), Gaps = 22/382 (5%)

Query: 393 NPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLN-EELVKAAANGDVAKVEDLL 451
           +P  + ++ S+ S   + +   L+++  K   +  +G ++   L +A ++GDV  V  LL
Sbjct: 168 DPEVLRRLTSSVSCALDEAAAALTRM--KAENSHNAGQVDTRSLAEACSDGDVNAVRKLL 225

Query: 452 KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGD-RAVHHAAFGDEG 510
                       G + +  A   G+ ++ ++LL  + +VE     GD   +  A+ G   
Sbjct: 226 DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYL 285

Query: 511 AVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDA 570
            ++++L    AD+N+++    T L  A   G + +VK LL+ G +    +  G TPL +A
Sbjct: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 571 ISKKRDDILAVLLEAGADVTITNNNGF--NALHHAALRGNPSAMRVLLSKLPRPWIVDEK 628
            S    ++  VLL+ GA +  T++N F  +AL  A  +G+   +R LL         + K
Sbjct: 346 ASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQ---EHK 401

Query: 629 KDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688
            D+ +TAL  A ++ HVEVA LL+  G A +++   + ++ L LA    H ++  LL+  
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSG-AQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 689 GAKLDIQDKDGDTPLHEALR--HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG 746
           GA L+  + +G TPL EA R  H  +  L   Q       ++A  E ++ T +  L   G
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG----ANINAQTEETQETALT-LACCG 515

Query: 747 AEKKSAASIACFLAANGADLSI 768
                 + +A FL   GAD+ +
Sbjct: 516 ----GFSEVADFLIKAGADIEL 533



 Score =  105 bits (263), Expect = 2e-22
 Identities = 96/339 (28%), Positives = 156/339 (46%), Gaps = 44/339 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA++G    +  LL   D DVN Q A G+TA+  A   G VDI+K+LL +  ++E  +++
Sbjct: 278 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
           G   +  AA      V  VL    A +N   N+ +++ L +A  KGHL +V+ LL+ G  
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVL 615
              +  E  T L +A      ++  +LL++GA V +  ++  + L  AA  G+     +L
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 616 LSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVN-QQTALHLAV 674
           + +      ++E  D+GYT L  AA   H E+  LL+ QG AN++ Q    Q+TAL LA 
Sbjct: 458 IERGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQG-ANINAQTEETQETALTLAC 513

Query: 675 ------------------------------ERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704
                                         +  H ++V+ L+ +GA +      GDT L 
Sbjct: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 705 EALRH-HT------LSQLRQLQDMQDVGKVDAAWEPSKN 736
            A  + HT      L     L   +D+  +    +P+K+
Sbjct: 574 YACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKH 612



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 79/272 (29%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD-T 565
           GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL    +   + ++GD T
Sbjct: 216 GDVNAVRKLLDEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
           PL  A S    DI+ +LL   ADV   +  G  AL +A   G    ++VLL++      +
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN---I 331

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           ++  ++G+T L  AA   HVEVA +L+  G       N  +++AL LA  + H  +VR L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           + AGA  + +  +  T L EA     +   R L D      + A    S  TL       
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL------- 444

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
            A       +A  L   GA+L   N +G +PL
Sbjct: 445 -AACGGHVELAALLIERGANLEEVNDEGYTPL 475



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 51/158 (32%), Positives = 80/158 (50%), Gaps = 8/158 (5%)

Query: 435 LVKAAANGDVAKVEDLLKRPD--VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEA 492
           L  AA  G V     L++R     +VN +  G+T +  A++ GH +++ LLL Q  ++ A
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 493 EDKDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
           + ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 556

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
            G +     + GDT L  A      D+  VLL+AGAD+
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)

Query: 427 ESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ 486
           ++ +  E  +  A  G  ++V D L +   D+   C+  T +  ASQ GH++++K LL  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLAS 557

Query: 487 NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLN 524
             +V A    GD A+ +A       V +VL +  ADL+
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  114 bits (286), Expect = 4e-25
 Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 7/300 (2%)

Query: 402 SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL--KRPDVDVN 459
           S   A S+     + +LL +     E  +  E L+  A +    ++  +L     +V+  
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 460 GQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG 519
           G     T + AAS  G++DI+KLLL  + DV ++   G+ A+ +A  G    +++VL   
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 520 SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE-GDTPLHDAISKKRDDI 578
            A++   N+   TPL  A + GH++V + LLD G   +   +E  ++ L  A  K   D+
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638
           +  LLEAGAD     +    AL  A + G+    R+LL    +   V+   D   + L L
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ---VNMPADSFESPLTL 433

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   HVE+A LL+ +G ANL+  N    T L  A    H ++V LL+  GA ++ Q ++
Sbjct: 434 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492



 Score =  107 bits (266), Expect = 7e-23
 Identities = 104/382 (27%), Positives = 184/382 (48%), Gaps = 22/382 (5%)

Query: 393 NPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLN-EELVKAAANGDVAKVEDLL 451
           +P  + ++ S+ S   + +   L+++  K   +  +G ++   L +A ++GDV  V  LL
Sbjct: 157 DPEVLRRLTSSVSCALDEAAAALTRM--KAENSHNAGQVDTRSLAEACSDGDVNAVRKLL 214

Query: 452 KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGD-RAVHHAAFGDEG 510
                       G + +  A   G+ ++ ++LL  + +VE     GD   +  A+ G   
Sbjct: 215 DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYL 274

Query: 511 AVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDA 570
            ++++L    AD+N+++    T L  A   G + +VK LL+ G +    +  G TPL +A
Sbjct: 275 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334

Query: 571 ISKKRDDILAVLLEAGADVTITNNNGF--NALHHAALRGNPSAMRVLLSKLPRPWIVDEK 628
            S    ++  VLL+ GA +  T++N F  +AL  A  +G+   +R LL         + K
Sbjct: 335 ASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQ---EHK 390

Query: 629 KDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688
            D+ +TAL  A ++ HVEVA LL+  G A +++   + ++ L LA    H ++  LL+  
Sbjct: 391 TDEMHTALMEACMDGHVEVARLLLDSG-AQVNMPADSFESPLTLAACGGHVELAALLIER 449

Query: 689 GAKLDIQDKDGDTPLHEALR--HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG 746
           GA L+  + +G TPL EA R  H  +  L   Q       ++A  E ++ T +  L   G
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG----ANINAQTEETQETALT-LACCG 504

Query: 747 AEKKSAASIACFLAANGADLSI 768
                 + +A FL   GAD+ +
Sbjct: 505 ----GFSEVADFLIKAGADIEL 522



 Score =  105 bits (263), Expect = 2e-22
 Identities = 96/339 (28%), Positives = 156/339 (46%), Gaps = 44/339 (12%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA++G    +  LL   D DVN Q A G+TA+  A   G VDI+K+LL +  ++E  +++
Sbjct: 267 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 326

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
           G   +  AA      V  VL    A +N   N+ +++ L +A  KGHL +V+ LL+ G  
Sbjct: 327 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 386

Query: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVL 615
              +  E  T L +A      ++  +LL++GA V +  ++  + L  AA  G+     +L
Sbjct: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446

Query: 616 LSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVN-QQTALHLAV 674
           + +      ++E  D+GYT L  AA   H E+  LL+ QG AN++ Q    Q+TAL LA 
Sbjct: 447 IERGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQG-ANINAQTEETQETALTLAC 502

Query: 675 ------------------------------ERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704
                                         +  H ++V+ L+ +GA +      GDT L 
Sbjct: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562

Query: 705 EALRH-HT------LSQLRQLQDMQDVGKVDAAWEPSKN 736
            A  + HT      L     L   +D+  +    +P+K+
Sbjct: 563 YACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKH 601



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 94/346 (27%), Positives = 150/346 (43%), Gaps = 29/346 (8%)

Query: 433 EELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEA 492
           E L++AAA  D   +  L       ++   A  T M+A  +N H               A
Sbjct: 147 EALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKA--ENSH--------------NA 190

Query: 493 EDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF 552
              D        + GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL  
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAM 249

Query: 553 GCHPSLQDSEGD-TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
             +   + ++GD TPL  A S    DI+ +LL   ADV   +  G  AL +A   G    
Sbjct: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309

Query: 612 MRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALH 671
           ++VLL++      +++  ++G+T L  AA   HVEVA +L+  G       N  +++AL 
Sbjct: 310 VKVLLNEGAN---IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366

Query: 672 LAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAW 731
           LA  + H  +VR L+ AGA  + +  +  T L EA     +   R L D      + A  
Sbjct: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426

Query: 732 EPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
             S  TL        A       +A  L   GA+L   N +G +PL
Sbjct: 427 FESPLTL--------AACGGHVELAALLIERGANLEEVNDEGYTPL 464



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 51/158 (32%), Positives = 80/158 (50%), Gaps = 8/158 (5%)

Query: 435 LVKAAANGDVAKVEDLLKRPD--VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEA 492
           L  AA  G V     L++R     +VN +  G+T +  A++ GH +++ LLL Q  ++ A
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINA 488

Query: 493 EDKDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
           + ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL 
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 545

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
            G +     + GDT L  A      D+  VLL+AGAD+
Sbjct: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 2/98 (2%)

Query: 427 ESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ 486
           ++ +  E  +  A  G  ++V D L +   D+   C+  T +  ASQ GH++++K LL  
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLAS 546

Query: 487 NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLN 524
             +V A    GD A+ +A       V +VL +  ADL+
Sbjct: 547 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  114 bits (286), Expect = 4e-25
 Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 7/300 (2%)

Query: 402 SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL--KRPDVDVN 459
           S   A S+     + +LL +     E  +  E L+  A +    ++  +L     +V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 460 GQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG 519
           G     T + AAS  G++DI+KLLL  + DV ++   G+ A+ +A  G    +++VL   
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 520 SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE-GDTPLHDAISKKRDDI 578
            A++   N+   TPL  A + GH++V + LLD G   +   +E  ++ L  A  K   D+
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638
           +  LLEAGAD     +    AL  A + G+    R+LL    +   V+   D   + L L
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ---VNMPADSFESPLTL 444

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   HVE+A LL+ +G ANL+  N    T L  A    H ++V LL+  GA ++ Q ++
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503



 Score =  113 bits (283), Expect = 8e-25
 Identities = 91/281 (32%), Positives = 140/281 (49%), Gaps = 12/281 (4%)

Query: 435  LVKAAANGDVAKVEDLL-KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA  G V  VE LL K  D++   +    T +  A   G  +++ LLL +  + E  
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR--NKRRQTPLHIAVNKGHLQVVKTLLD 551
            +      +  AA G    +I++L    A++N+R  +K   +PL +A   GH+  VK LLD
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211

Query: 552  FGCHPSLQ-DSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G   + Q ++  +T L  A  + R +++++LL+  A+V      G   L  AA  G   
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271

Query: 611  AMRVLLSK---LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQ 667
              RVLL K   +  P +   +     TAL +AA   H +  ELL+H+G A++D++N    
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIHRG-AHIDVRNKKGN 1326

Query: 668  TALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
            T L LA    H  +V+LLV+AGA +D  D    TPL  A R
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367



 Score =  104 bits (260), Expect = 4e-22
 Identities = 106/404 (26%), Positives = 171/404 (42%), Gaps = 73/404 (18%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA++G    +  LL   D DVN Q A G+TA+  A   G VDI+K+LL +  ++E  +++
Sbjct: 278 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
           G   +  AA      V  VL    A +N   N+ +++ L +A  KGHL +V+ LL+ G  
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTI------------------------ 591
              +  E  T L +A      ++  +LL++GA V +                        
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 592 ---------TNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
                     N+ G+  L  AA  G+   + +LL++     I  + ++   TAL LA   
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN--INAQTEETQETALTLACCG 515

Query: 643 NHVEVAELLVHQG-----------------------------NANLDIQNVNQQTALHLA 673
              EVA+ L+  G                              AN+        TAL  A
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 674 VERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEP 733
            E  HT +  +L++AGA L+ + + G TPL +A R   L  ++ L  +     V+ A   
Sbjct: 576 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL--ISKGANVNRATAN 633

Query: 734 SKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
           + +T ++ L   G       ++   L A+GAD + R K G + L
Sbjct: 634 NDHT-VVSLACAGGH----LAVVELLLAHGADPTHRLKDGSTML 672



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 93/325 (28%), Positives = 144/325 (44%), Gaps = 43/325 (13%)

Query: 455  DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIE 514
            D+D + +    TA+  A   GH +++ +L+ ++  +E  DK G   +  AA      V+E
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 515  VLHRGSADLNARNKR-RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
            +L     D+ A+++R + TPL +A + G  +VV  LL  G +   ++    TPL  A S 
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 574  KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGY 633
               +I+ +LL AGA++                           SKL            G 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTG----------------------SKL------------GI 1191

Query: 634  TALHLAALNNHVEVAELLVHQGN-ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKL 692
            + L LAA+N HV   +LL+  G+  N  I+  N+ TAL LA  +   ++V LL+   A +
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIET-NRNTALTLACFQGRAEVVSLLLDRKANV 1250

Query: 693  DIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSA 752
            + + K G TPL EA         R L D      V+A   PS     + +    A  K  
Sbjct: 1251 EHRAKTGLTPLMEAASGGYAEVGRVLLDKG--ADVNAPPVPSSRDTALTI----AADKGH 1304

Query: 753  ASIACFLAANGADLSIRNKKGQSPL 777
                  L   GA + +RNKKG +PL
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPL 1329



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 76/255 (29%), Positives = 123/255 (48%), Gaps = 11/255 (4%)

Query: 435 LVKAAANGDVAKVEDLLKRPD--VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEA 492
           L  AA  G V     L++R     +VN +  G+T +  A++ GH +++ LLL Q  ++ A
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 493 EDKDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
           + ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 556

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
            G +     + GDT L  A      D+  VLL+AGAD+   +  G   L  AA  G+   
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 612 MRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALH 671
           ++ L+SK     +     ++ +T + LA    H+ V ELL+  G A+   +  +  T L 
Sbjct: 617 VQFLISKGAN--VNRATANNDHTVVSLACAGGHLAVVELLLAHG-ADPTHRLKDGSTMLI 673

Query: 672 LAVERQHTQIVRLLV 686
            A +  HT +V  L+
Sbjct: 674 EAAKGGHTNVVSYLL 688



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 59/188 (31%), Positives = 96/188 (51%), Gaps = 3/188 (1%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA NG V  V+ LL    D++   +   +TA+  A   G  +++ LLL +  +VE  
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARN--KRRQTPLHIAVNKGHLQVVKTLLD 551
             K G   +  AA G    V  VL    AD+NA      R T L IA +KGH +  + L+ 
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIH 1313

Query: 552  FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
             G H  +++ +G+TPL  A +    D++ +L++AGADV   +N     L  A  +G+   
Sbjct: 1314 RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKV 1373

Query: 612  MRVLLSKL 619
            ++ L+ ++
Sbjct: 1374 VQYLVKEV 1381



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 79/272 (29%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD-T 565
           GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL    +   + ++GD T
Sbjct: 216 GDVNAVRKLLDEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
           PL  A S    DI+ +LL   ADV   +  G  AL +A   G    ++VLL++      +
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN---I 331

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           ++  ++G+T L  AA   HVEVA +L+  G       N  +++AL LA  + H  +VR L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           + AGA  + +  +  T L EA     +   R L D      + A    S  TL       
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL------- 444

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
            A       +A  L   GA+L   N +G +PL
Sbjct: 445 -AACGGHVELAALLIERGANLEEVNDEGYTPL 475



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 3/191 (1%)

Query: 427 ESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ 486
           ++ +  E  +  A  G  ++V D L +   D+   C+  T +  ASQ GH++++K LL  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLAS 557

Query: 487 NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVV 546
             +V A    GD A+ +A       V +VL +  ADL   ++  +TPL  A   GHL  V
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617

Query: 547 KTLLDFGCHPSLQDSEGD-TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAAL 605
           + L+  G + +   +  D T +  A +     ++ +LL  GAD T    +G   L  AA 
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677

Query: 606 RGNPSAMRVLL 616
            G+ + +  LL
Sbjct: 678 GGHTNVVSYLL 688



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 40/141 (28%), Positives = 71/141 (50%), Gaps = 3/141 (2%)

Query: 413  ERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQ---CAGHTAMQ 469
            E +S LL +    +         +  AA+G  A+V  +L     DVN      +  TA+ 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 470  AASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529
             A+  GH    +LL+ +   ++  +K G+  +  A+ G    V+++L +  AD++A + R
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 530  RQTPLHIAVNKGHLQVVKTLL 550
            + TPL  A  KGH++VV+ L+
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLV 1378



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 48/170 (28%), Positives = 77/170 (45%), Gaps = 14/170 (8%)

Query: 665  NQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDV 724
            N  TAL LA    H ++V +L+   AK++ +DK G TPL  A     +  +  L D    
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG-- 1111

Query: 725  GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPD-- 782
            G ++A  E +K+T  + L   G  ++    +   L A GA+   RN    +PL L     
Sbjct: 1112 GDIEAQSERTKDT-PLSLACSGGRQE----VVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 783  -PNLCKALAKCHKEKVSGQVGSR---SPSMISNDSETLEECMVCSDMKRD 828
              N+ K L     E ++ + GS+   SP M++  +  +    +  DM  D
Sbjct: 1167 YVNIIKILLNAGAE-INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/214 (25%), Positives = 84/214 (39%), Gaps = 16/214 (7%)

Query: 352 QRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVAS----AGSAI 407
           + GH E    +L     +    +   ++ L +  CG         +   A       + +
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPL 539

Query: 408 SNASGERLSQLLKKLFE-------TQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG 460
             AS E   +L+K L         T  +GD    L  A  NG    V D+L +   D+  
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDT--ALTYACENGHT-DVADVLLQAGADLEH 596

Query: 461 QC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHH-AAFGDEGAVIEVLHR 518
           +   G T +  A++ GH+  ++ L+ +  +V     + D  V   A  G   AV+E+L  
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF 552
             AD   R K   T L  A   GH  VV  LLD+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  114 bits (286), Expect = 4e-25
 Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 7/300 (2%)

Query: 402 SAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL--KRPDVDVN 459
           S   A S+     + +LL +     E  +  E L+  A +    ++  +L     +V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 460 GQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG 519
           G     T + AAS  G++DI+KLLL  + DV ++   G+ A+ +A  G    +++VL   
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 520 SADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE-GDTPLHDAISKKRDDI 578
            A++   N+   TPL  A + GH++V + LLD G   +   +E  ++ L  A  K   D+
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638
           +  LLEAGAD     +    AL  A + G+    R+LL    +   V+   D   + L L
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ---VNMPADSFESPLTL 444

Query: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
           AA   HVE+A LL+ +G ANL+  N    T L  A    H ++V LL+  GA ++ Q ++
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503



 Score =  113 bits (283), Expect = 8e-25
 Identities = 91/281 (32%), Positives = 140/281 (49%), Gaps = 12/281 (4%)

Query: 435  LVKAAANGDVAKVEDLL-KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA  G V  VE LL K  D++   +    T +  A   G  +++ LLL +  + E  
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNAR--NKRRQTPLHIAVNKGHLQVVKTLLD 551
            +      +  AA G    +I++L    A++N+R  +K   +PL +A   GH+  VK LLD
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211

Query: 552  FGCHPSLQ-DSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G   + Q ++  +T L  A  + R +++++LL+  A+V      G   L  AA  G   
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271

Query: 611  AMRVLLSK---LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQ 667
              RVLL K   +  P +   +     TAL +AA   H +  ELL+H+G A++D++N    
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIHRG-AHIDVRNKKGN 1326

Query: 668  TALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
            T L LA    H  +V+LLV+AGA +D  D    TPL  A R
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367



 Score =  104 bits (260), Expect = 4e-22
 Identities = 106/404 (26%), Positives = 171/404 (42%), Gaps = 73/404 (18%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKD 496
           AA++G    +  LL   D DVN Q A G+TA+  A   G VDI+K+LL +  ++E  +++
Sbjct: 278 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 497 GDRAVHHAAFGDEGAVIEVLHRGSADLNAR-NKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
           G   +  AA      V  VL    A +N   N+ +++ L +A  KGHL +V+ LL+ G  
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTI------------------------ 591
              +  E  T L +A      ++  +LL++GA V +                        
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 592 ---------TNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
                     N+ G+  L  AA  G+   + +LL++     I  + ++   TAL LA   
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN--INAQTEETQETALTLACCG 515

Query: 643 NHVEVAELLVHQG-----------------------------NANLDIQNVNQQTALHLA 673
              EVA+ L+  G                              AN+        TAL  A
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 674 VERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEP 733
            E  HT +  +L++AGA L+ + + G TPL +A R   L  ++ L  +     V+ A   
Sbjct: 576 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL--ISKGANVNRATAN 633

Query: 734 SKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
           + +T ++ L   G       ++   L A+GAD + R K G + L
Sbjct: 634 NDHT-VVSLACAGGH----LAVVELLLAHGADPTHRLKDGSTML 672



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 93/325 (28%), Positives = 144/325 (44%), Gaps = 43/325 (13%)

Query: 455  DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIE 514
            D+D + +    TA+  A   GH +++ +L+ ++  +E  DK G   +  AA      V+E
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 515  VLHRGSADLNARNKR-RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
            +L     D+ A+++R + TPL +A + G  +VV  LL  G +   ++    TPL  A S 
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 574  KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGY 633
               +I+ +LL AGA++                           SKL            G 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTG----------------------SKL------------GI 1191

Query: 634  TALHLAALNNHVEVAELLVHQGN-ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKL 692
            + L LAA+N HV   +LL+  G+  N  I+  N+ TAL LA  +   ++V LL+   A +
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIET-NRNTALTLACFQGRAEVVSLLLDRKANV 1250

Query: 693  DIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSA 752
            + + K G TPL EA         R L D      V+A   PS     + +    A  K  
Sbjct: 1251 EHRAKTGLTPLMEAASGGYAEVGRVLLDKG--ADVNAPPVPSSRDTALTI----AADKGH 1304

Query: 753  ASIACFLAANGADLSIRNKKGQSPL 777
                  L   GA + +RNKKG +PL
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPL 1329



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 76/255 (29%), Positives = 123/255 (48%), Gaps = 11/255 (4%)

Query: 435 LVKAAANGDVAKVEDLLKRPD--VDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEA 492
           L  AA  G V     L++R     +VN +  G+T +  A++ GH +++ LLL Q  ++ A
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 493 EDKDG-DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
           + ++  + A+  A  G    V + L +  AD+        TPL  A  +GHL++VK LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 556

Query: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
            G +     + GDT L  A      D+  VLL+AGAD+   +  G   L  AA  G+   
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 612 MRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALH 671
           ++ L+SK     +     ++ +T + LA    H+ V ELL+  G A+   +  +  T L 
Sbjct: 617 VQFLISKGAN--VNRATANNDHTVVSLACAGGHLAVVELLLAHG-ADPTHRLKDGSTMLI 673

Query: 672 LAVERQHTQIVRLLV 686
            A +  HT +V  L+
Sbjct: 674 EAAKGGHTNVVSYLL 688



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 59/188 (31%), Positives = 96/188 (51%), Gaps = 3/188 (1%)

Query: 435  LVKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAE 493
            L+ AA NG V  V+ LL    D++   +   +TA+  A   G  +++ LLL +  +VE  
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253

Query: 494  DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARN--KRRQTPLHIAVNKGHLQVVKTLLD 551
             K G   +  AA G    V  VL    AD+NA      R T L IA +KGH +  + L+ 
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIH 1313

Query: 552  FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
             G H  +++ +G+TPL  A +    D++ +L++AGADV   +N     L  A  +G+   
Sbjct: 1314 RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKV 1373

Query: 612  MRVLLSKL 619
            ++ L+ ++
Sbjct: 1374 VQYLVKEV 1381



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 79/272 (29%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGD-T 565
           GD  AV ++L  G + +N   +  ++ L +A + G+ ++ + LL    +   + ++GD T
Sbjct: 216 GDVNAVRKLLDEGRS-VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
           PL  A S    DI+ +LL   ADV   +  G  AL +A   G    ++VLL++      +
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN---I 331

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           ++  ++G+T L  AA   HVEVA +L+  G       N  +++AL LA  + H  +VR L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           + AGA  + +  +  T L EA     +   R L D      + A    S  TL       
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL------- 444

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
            A       +A  L   GA+L   N +G +PL
Sbjct: 445 -AACGGHVELAALLIERGANLEEVNDEGYTPL 475



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 3/191 (1%)

Query: 427 ESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ 486
           ++ +  E  +  A  G  ++V D L +   D+   C+  T +  ASQ GH++++K LL  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLAS 557

Query: 487 NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVV 546
             +V A    GD A+ +A       V +VL +  ADL   ++  +TPL  A   GHL  V
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617

Query: 547 KTLLDFGCHPSLQDSEGD-TPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAAL 605
           + L+  G + +   +  D T +  A +     ++ +LL  GAD T    +G   L  AA 
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677

Query: 606 RGNPSAMRVLL 616
            G+ + +  LL
Sbjct: 678 GGHTNVVSYLL 688



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 40/141 (28%), Positives = 71/141 (50%), Gaps = 3/141 (2%)

Query: 413  ERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQ---CAGHTAMQ 469
            E +S LL +    +         +  AA+G  A+V  +L     DVN      +  TA+ 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 470  AASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529
             A+  GH    +LL+ +   ++  +K G+  +  A+ G    V+++L +  AD++A + R
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 530  RQTPLHIAVNKGHLQVVKTLL 550
            + TPL  A  KGH++VV+ L+
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLV 1378



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 48/170 (28%), Positives = 77/170 (45%), Gaps = 14/170 (8%)

Query: 665  NQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDV 724
            N  TAL LA    H ++V +L+   AK++ +DK G TPL  A     +  +  L D    
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG-- 1111

Query: 725  GKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPD-- 782
            G ++A  E +K+T  + L   G  ++    +   L A GA+   RN    +PL L     
Sbjct: 1112 GDIEAQSERTKDT-PLSLACSGGRQE----VVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 783  -PNLCKALAKCHKEKVSGQVGSR---SPSMISNDSETLEECMVCSDMKRD 828
              N+ K L     E ++ + GS+   SP M++  +  +    +  DM  D
Sbjct: 1167 YVNIIKILLNAGAE-INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/214 (25%), Positives = 84/214 (39%), Gaps = 16/214 (7%)

Query: 352 QRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVAS----AGSAI 407
           + GH E    +L     +    +   ++ L +  CG         +   A       + +
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPL 539

Query: 408 SNASGERLSQLLKKLFE-------TQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG 460
             AS E   +L+K L         T  +GD    L  A  NG    V D+L +   D+  
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDT--ALTYACENGHT-DVADVLLQAGADLEH 596

Query: 461 QC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHH-AAFGDEGAVIEVLHR 518
           +   G T +  A++ GH+  ++ L+ +  +V     + D  V   A  G   AV+E+L  
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF 552
             AD   R K   T L  A   GH  VV  LLD+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  114 bits (286), Expect = 4e-25
 Identities = 95/356 (26%), Positives = 162/356 (45%), Gaps = 31/356 (8%)

Query: 354 GHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGE 413
           GH E   A+L    KV       +D+D +  +   +W  +   V  +   G+ ++ A  E
Sbjct: 622 GHTEVVSALLYAGVKVD-----CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE 676

Query: 414 RLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAAS- 472
             + L+   +      ++ E L+   A          +   DVD      G TA+  A+ 
Sbjct: 677 GRTALIAAAYMGHR--EIVEHLLDHGAE---------VNHEDVD------GRTALSVAAL 719

Query: 473 ----QNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNK 528
                 GH  ++ LL+ +  +V+  DKDG   +  AA+     V+++L  G AD++  + 
Sbjct: 720 CVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDN 779

Query: 529 RRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 588
             +TPL  A + GH  VV TLL +G      DSEG T L  A ++   +++  LL+ G D
Sbjct: 780 NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839

Query: 589 VTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVA 648
               ++ G+  LH AA  G+      L+ +  R    +E  +DG     LA+   H +  
Sbjct: 840 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR---TNEIDNDGRIPFILASQEGHYDCV 896

Query: 649 ELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704
           ++L+ +  +N+D +  + + AL +A    H  IV LL   GA ++ +D DG   L+
Sbjct: 897 QILL-ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLY 951



 Score =  103 bits (256), Expect = 1e-21
 Identities = 84/304 (27%), Positives = 148/304 (48%), Gaps = 14/304 (4%)

Query: 395  AAVSKVASAGS---AISNASG--ERLSQLLKKLFETQESGDLN-EELVKAAANGDVAKVE 448
            AAV  + S G    +I++A G  E +  LL +  +     D     L  AA  G     E
Sbjct: 805  AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 864

Query: 449  DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD 508
             L+++          G      ASQ GH D +++LL+   +++    DG  A+  AA   
Sbjct: 865  ALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEG 924

Query: 509  EGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLH 568
               ++E+L    AD+N ++   +  L+I   +  L + +  L+ G +    D+EG T LH
Sbjct: 925  HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH 984

Query: 569  DAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEK 628
             +  +   +++ VL+   ADV   +N   +AL  AA +G+   +++L+       +VD  
Sbjct: 985  VSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE---HGAVVDHT 1041

Query: 629  KDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ--QTALHLAVERQHTQIVRLLV 686
             + G TAL +AA   H++V ++L+  G    D  + +Q  +TA+ +A +  H+QI++LL 
Sbjct: 1042 CNQGATALCIAAQEGHIDVVQVLLEHG---ADPNHADQFGRTAMRVAAKNGHSQIIKLLE 1098

Query: 687  RAGA 690
            + GA
Sbjct: 1099 KYGA 1102



 Score =  101 bits (252), Expect = 3e-21
 Identities = 79/245 (32%), Positives = 117/245 (47%), Gaps = 9/245 (3%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G T +  A+ +G +D++ LL+ +  D+E ED  G   +  AA      V+  L    A++
Sbjct: 545 GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583
           N  ++   T L  A   GH +VV  LL  G      D++  T L  A     +DI+  LL
Sbjct: 605 NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664

Query: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL-- 641
           + GA+V   +N G  AL  AA  G+   +  LL        V+ +  DG TAL +AAL  
Sbjct: 665 QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE---VNHEDVDGRTALSVAALCV 721

Query: 642 ---NNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698
                H  V  LL+ +G A +D  + +  T L +A    H  +V LL+  GA +D  D +
Sbjct: 722 PASKGHASVVSLLIDRG-AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780

Query: 699 GDTPL 703
           G TPL
Sbjct: 781 GRTPL 785



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 72/231 (31%), Positives = 116/231 (50%), Gaps = 9/231 (3%)

Query: 478 DILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIA 537
           D ++ LL     V   D +G   + +AA+     V+ +L    ADL   +    TPL +A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585

Query: 538 VNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGF 597
             +GH +VV  L+  G + +  D +G T L  A      ++++ LL AG  V   + +  
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645

Query: 598 NALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNA 657
            AL  AA  G+     ++L+ L     V++  ++G TAL  AA   H E+ E L+  G A
Sbjct: 646 TALRAAAWGGHED---IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG-A 701

Query: 658 NLDIQNVNQQTALHLA-----VERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            ++ ++V+ +TAL +A       + H  +V LL+  GA++D  DKDG TPL
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 752



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 65/226 (28%), Positives = 116/226 (51%), Gaps = 5/226 (2%)

Query: 436  VKAAANGDVAKVEDLLK-RPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
            + A+  G    V+ LL+ + ++D  G   G  A++ A+  GH DI++LL     DV  +D
Sbjct: 885  ILASQEGHYDCVQILLENKSNIDQRGY-DGRNALRVAALEGHRDIVELLFSHGADVNCKD 943

Query: 495  KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
             DG   ++  A  ++  + E      A++ A +   +T LH++  +GH+++V+ L+ +  
Sbjct: 944  ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003

Query: 555  HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRV 614
              +  D+E  + L  A  +    ++ +L+E GA V  T N G  AL  AA  G+   ++V
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063

Query: 615  LLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD 660
            LL     P   D+    G TA+ +AA N H ++ +LL   G ++L+
Sbjct: 1064 LLEHGADPNHADQ---FGRTAMRVAAKNGHSQIIKLLEKYGASSLN 1106



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 71/269 (26%), Positives = 124/269 (46%), Gaps = 4/269 (1%)

Query: 435  LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
            L+ AA+ G  + V  LL       +    G T +  AS  G+V++++ LL + +D    D
Sbjct: 785  LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844

Query: 495  KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
              G   +H AAF     + E L    A  N  +   + P  +A  +GH   V+ LL+   
Sbjct: 845  DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904

Query: 555  HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRV 614
            +   +  +G   L  A  +   DI+ +L   GADV   + +G   L+  AL    +    
Sbjct: 905  NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964

Query: 615  LLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAV 674
             L        V+    +G TALH++    H+E+ ++L+   +A+++  +  +++AL  A 
Sbjct: 965  FLENGAN---VEASDAEGRTALHVSCWQGHMEMVQVLIAY-HADVNAADNEKRSALQSAA 1020

Query: 675  ERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
             + H ++V+LL+  GA +D     G T L
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 71/269 (26%), Positives = 122/269 (45%), Gaps = 9/269 (3%)

Query: 509 EGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLH 568
           E  V+++L +  A +N+ + R    +  A+ +     ++TLLD G   +  DS G T L 
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550

Query: 569 DAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEK 628
           +A      D++ +L+  GAD+ I + +G   L  AA +G+   +  L+        ++  
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN---INHT 607

Query: 629 KDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688
             DG+TAL  AA   H EV   L++ G   +D  + + +TAL  A    H  IV  L++ 
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAG-VKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666

Query: 689 GAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAE 748
           GA+++  D +G T L  A     +     ++ + D G      +    T +         
Sbjct: 667 GAEVNKADNEGRTALIAAAY---MGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPA 723

Query: 749 KKSAASIACFLAANGADLSIRNKKGQSPL 777
            K  AS+   L   GA++   +K G +PL
Sbjct: 724 SKGHASVVSLLIDRGAEVDHCDKDGMTPL 752



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 70/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 565 TPLHDAISK---KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPR 621
           TP+ D++S    K  ++L +L++AGA V   ++     +  A  R +  ++R LL     
Sbjct: 480 TPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERED--SIRTLLDNGAS 537

Query: 622 PWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQI 681
              V++   +G T L  AA +  ++V  LLV +G A+L+I++ +  T L LA  + HT++
Sbjct: 538 ---VNQCDSNGRTLLANAAYSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTKV 593

Query: 682 VRLLVRAGAKLDIQDKDGDTPLHEAL---RHHTLSQLRQLQDMQDVGKVD-------AAW 731
           V  L+  GA ++  D+DG T L  A        +S L       D    D       AAW
Sbjct: 594 VNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAW 653

Query: 732 EPSKNTLIMGLGTQGAEKKSA----------------ASIACFLAANGADLSIRNKKGQS 775
              ++ +++ L   GAE   A                  I   L  +GA+++  +  G++
Sbjct: 654 GGHED-IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRT 712

Query: 776 PLDLCPDPNLCKALAKCHKEKVS 798
            L +     LC   +K H   VS
Sbjct: 713 ALSVAA---LCVPASKGHASVVS 732



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 4/107 (3%)

Query: 435  LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
            L  AA  G V  V+ L++   V  +    G TA+  A+Q GH+D++++LL+   D    D
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075

Query: 495  KDGDRAVHHAAFGDEGAVIEVLHR-GSADLNARNKRRQTPLHIAVNK 540
            + G  A+  AA      +I++L + G++ LN  +    +P+H    K
Sbjct: 1076 QFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCS---PSPVHTMEQK 1119


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  112 bits (281), Expect = 1e-24
 Identities = 95/278 (34%), Positives = 138/278 (49%), Gaps = 15/278 (5%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
           L++A   G    V  LL++         AG T +  A   GH  +++LLL++   V A D
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF-G 553
           + G  A+H AA+     V E+L +  A   AR+    TPLH A   GH  +   LL+  G
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164

Query: 554 CHPS---LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             P+    +D+ G T  H A +  R  +L +L   GA +         AL  AA  G  +
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGA 217

Query: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTAL 670
           A+R LL++  R   VD +   G TAL LAA     +  E+L+  G A+  I++ + ++AL
Sbjct: 218 ALRFLLARGAR---VDARDGAGATALGLAAALGRSQDIEVLLGHG-ADPGIRDRHGRSAL 273

Query: 671 HLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
           H A  R H   V+LLV  GA++D +D  G TPLH A R
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311



 Score =  100 bits (248), Expect = 9e-21
 Identities = 90/260 (34%), Positives = 124/260 (47%), Gaps = 15/260 (5%)

Query: 435 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQN----VDV 490
           L +AA +G     E LL+R          G T +  A+  GH  +   LL+         
Sbjct: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170

Query: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
           EAED  G  A H AA G   AV+E+L  G A L+         L +A   G    ++ LL
Sbjct: 171 EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLL 223

Query: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
             G     +D  G T L  A +  R   + VLL  GAD  I + +G +ALH AA RG+  
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283

Query: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTAL 670
           A+++L+++      VD +   G T LH A+   HVEVA  L+ +G A +D     ++T L
Sbjct: 284 AVQLLVTQGAE---VDARDTLGLTPLHHASREGHVEVAGCLLDRG-AQVDATGWLRKTPL 339

Query: 671 HLAVERQHTQIVRLLVRAGA 690
           HLA ER H   V LL+  GA
Sbjct: 340 HLAAERGHGPTVGLLLSRGA 359



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 79/272 (29%), Positives = 115/272 (42%), Gaps = 51/272 (18%)

Query: 507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTP 566
           G  G V ++L +G A +  R+   +TPLH+AV +GH  +V+ LL  G      D  G T 
Sbjct: 52  GPAGLVTQLLRQG-ASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTA 110

Query: 567 LHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS-AMRVLLSKLPRPWIV 625
           LH+A       +  +LL+ GA     +  G   LH AA  G+   A R+L +  P P   
Sbjct: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170

Query: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685
           + +   G+TA H AA    + V ELL   G A LD        AL +A        +R L
Sbjct: 171 EAEDARGWTAAHWAAAGGRLAVLELLA-AGGAGLD-------GALLVAAAAGRGAALRFL 222

Query: 686 VRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQ 745
           +  GA++D +D  G T L  A      + L + QD++                       
Sbjct: 223 LARGARVDARDGAGATALGLA------AALGRSQDIE----------------------- 253

Query: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
                        L  +GAD  IR++ G+S L
Sbjct: 254 ------------VLLGHGADPGIRDRHGRSAL 273



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 61/185 (32%), Positives = 88/185 (47%), Gaps = 7/185 (3%)

Query: 438 AAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDG 497
           AAA G +A +E LL      ++G      A+  A+  G    L+ LL +   V+A D  G
Sbjct: 184 AAAGGRLAVLE-LLAAGGAGLDG------ALLVAAAAGRGAALRFLLARGARVDARDGAG 236

Query: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
             A+  AA       IEVL    AD   R++  ++ LH A  +GHL  V+ L+  G    
Sbjct: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296

Query: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
            +D+ G TPLH A  +   ++   LL+ GA V  T       LH AA RG+   + +LLS
Sbjct: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356

Query: 618 KLPRP 622
           +   P
Sbjct: 357 RGASP 361



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 62/200 (31%), Positives = 93/200 (46%), Gaps = 5/200 (2%)

Query: 394 PAAVSKVASAGSAISN--ASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL 451
           PAA     + G   ++  A+G RL+ L  +L     +G L+  L+ AAA G  A +  LL
Sbjct: 167 PAAAEAEDARGWTAAHWAAAGGRLAVL--ELLAAGGAG-LDGALLVAAAAGRGAALRFLL 223

Query: 452 KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGA 511
            R         AG TA+  A+  G    +++LL    D    D+ G  A+H AA      
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283

Query: 512 VIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAI 571
            +++L    A+++AR+    TPLH A  +GH++V   LLD G           TPLH A 
Sbjct: 284 AVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAA 343

Query: 572 SKKRDDILAVLLEAGADVTI 591
            +     + +LL  GA  T+
Sbjct: 344 ERGHGPTVGLLLSRGASPTL 363



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 8/111 (7%)

Query: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
           G +A+  A+  GH+  ++LL+ Q  +V+A D  G   +HHA+      V   L    A +
Sbjct: 269 GRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328

Query: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSL--------QDSEGDTP 566
           +A    R+TPLH+A  +GH   V  LL  G  P+L        Q  EGD P
Sbjct: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLP 379


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score =  111 bits (277), Expect = 4e-24
 Identities = 107/391 (27%), Positives = 185/391 (47%), Gaps = 36/391 (9%)

Query: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLL-LKQNVDV 490
           ++EL++AA  G+VA VE LL           +G         +G + +  LL + +  +V
Sbjct: 4   DQELLEAARTGNVALVEKLL-----------SGRKGGILGGGSGPLPLSNLLSIWRGPNV 52

Query: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
              D  G  A+HHAA      ++  L +  A  N  + +   P+H+A  KG +++VK L+
Sbjct: 53  NCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILI 112

Query: 551 DFGCHPSL---QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRG 607
             G   S    Q++E +T LH A      +++AVLLE   D TI N+     L  AAL G
Sbjct: 113 HHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYG 172

Query: 608 NPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ-NVNQ 666
               +++++S  P     + +K   +T LHLAA N H  V ++L+  G   +D+     +
Sbjct: 173 RLRVVKMIISAHPNLMSCNTRK---HTPLHLAARNGHKAVVQVLLEAG---MDVSCQTEK 226

Query: 667 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL-----QDM 721
            +ALH A       +VR+L+  G   +I+D  G T L + L+ H   +  Q+     + +
Sbjct: 227 GSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL-DILKEHPSQKSLQIATLLQEYL 285

Query: 722 QDVGKVDAAWEP-----SKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSP 776
           + VG+     EP     ++ T I       ++K  + ++   L+    ++ +  +K  S 
Sbjct: 286 EGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSF 345

Query: 777 LDLCP--DPNLCKALAKCHKEKVSGQVGSRS 805
            DLC     +    L+K  +E++ G+ GS+S
Sbjct: 346 EDLCHTISDHYLDNLSKISEEEL-GKNGSQS 375



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 63/232 (27%), Positives = 115/232 (49%), Gaps = 11/232 (4%)

Query: 401 ASAGSAISNASGERLSQLLKKLFETQESGDLNEE-----LVKAAANGDVAKVEDLLKRPD 455
           +S  +A+ +A+      ++ KL + + S ++ +      +  AA  GDV  V+ L+    
Sbjct: 57  SSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGP 116

Query: 456 VD--VNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAV 512
               VN Q     TA+  A+Q GH +++ +LL++  D    +   +  +  AA      V
Sbjct: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRV 176

Query: 513 IEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572
           ++++     +L + N R+ TPLH+A   GH  VV+ LL+ G   S Q  +G + LH+A  
Sbjct: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAAL 235

Query: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI 624
             + D++ VLLE G D  I ++ G   L    L+ +PS   + ++ L + ++
Sbjct: 236 FGKVDVVRVLLETGIDANIKDSLGRTVLD--ILKEHPSQKSLQIATLLQEYL 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,350,439
Number of Sequences: 37866
Number of extensions: 1902832
Number of successful extensions: 10995
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 441
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 4859
Number of HSP's gapped (non-prelim): 2598
length of query: 1006
length of database: 18,247,518
effective HSP length: 112
effective length of query: 894
effective length of database: 14,006,526
effective search space: 12521834244
effective search space used: 12521834244
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.