Search of human proteins with 30089994

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
         (274 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso...   557   e-159
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso...   553   e-158
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        127   1e-29
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       112   5e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        112   5e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        112   5e-25
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    106   2e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   103   2e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       103   2e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        103   2e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        103   2e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        103   2e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        103   2e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   102   4e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   102   5e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   100   2e-21
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  94   1e-19
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    94   1e-19
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   93   3e-19
gi|116325987 ankyrin repeat domain 42 [Homo sapiens]                   92   4e-19
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       92   5e-19
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         91   1e-18
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         91   1e-18
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         91   1e-18
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]         91   1e-18
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]         91   1e-18
gi|34304381 inversin isoform a [Homo sapiens]                          91   1e-18
gi|34304379 inversin isoform b [Homo sapiens]                          91   1e-18
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          91   1e-18
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...    91   1e-18

>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
           isoform 1 [Homo sapiens]
          Length = 274

 Score =  557 bits (1435), Expect = e-159
 Identities = 274/274 (100%), Positives = 274/274 (100%)

Query: 1   MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
           MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
Sbjct: 1   MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60

Query: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
           RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
Sbjct: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
           LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
Sbjct: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180

Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
           GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
Sbjct: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240

Query: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTSM 274
           NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTSM
Sbjct: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTSM 274


>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
           isoform 2 [Homo sapiens]
          Length = 318

 Score =  553 bits (1426), Expect = e-158
 Identities = 272/272 (100%), Positives = 272/272 (100%)

Query: 1   MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
           MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
Sbjct: 1   MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60

Query: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
           RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
Sbjct: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
           LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
Sbjct: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180

Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
           GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
Sbjct: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240

Query: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT 272
           NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT
Sbjct: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT 272


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  127 bits (318), Expect = 1e-29
 Identities = 86/244 (35%), Positives = 120/244 (49%), Gaps = 10/244 (4%)

Query: 13  QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
           Q  L I A +   D+  V+++L+QG SPN    +G+T LH SA  G E      L+HGA 
Sbjct: 500 QTPLHISARLGKADI--VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 73  PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
            ++     GFT LH AA +G+  +A L+L+     D   A    G TPLHVAAHY     
Sbjct: 558 LSITTK-KGFTPLHVAAKYGKLEVANLLLQKSASPD---AAGKSGLTPLHVAAHYDNQKV 613

Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIK 190
             LLL+  A     +  G TPL +A  + +      LL++  +AN   + G    +   +
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673

Query: 191 SNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
             H     + L R A+ NL   + G TPLHL+A  D V  A +L N GA  + +   G T
Sbjct: 674 EGHVDMVSLLLGRNANVNLSN-KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732

Query: 250 PLAV 253
           PL V
Sbjct: 733 PLHV 736



 Score = 99.4 bits (246), Expect = 3e-21
 Identities = 69/231 (29%), Positives = 110/231 (47%), Gaps = 8/231 (3%)

Query: 27  VHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALH 86
           +  +  +L+ G S      +G T +H +A  G    V   + HGA P   + + G TALH
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN-VRGETALH 471

Query: 87  YAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPL 146
            AA  G+A + R +++   +   + AK+ D  TPLH++A  G+   V+ LL+  A  +  
Sbjct: 472 MAARSGQAEVVRYLVQDGAQ---VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528

Query: 147 SDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNHSYCRMFLQRG 203
           +  G TPL L+           LLDH A++ I  + GF  L  A          + LQ+ 
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 204 ADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           A  +    + G TPLH++A  D+   A +L + GA  +     G TPL ++
Sbjct: 589 ASPDAAG-KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638



 Score = 98.6 bits (244), Expect = 5e-21
 Identities = 73/259 (28%), Positives = 119/259 (45%), Gaps = 33/259 (12%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A  AG    V+ ++  G + N +  NG+T L+ +A       V+  L++GA  ++  
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA- 169

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDI--------------------------IN 111
              GFT L  A   G  ++  L+LE++ +  +                           +
Sbjct: 170 TEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229

Query: 112 AKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLD 171
            +S  G+TPLH+AAHYG  +   LLL   A VD  +    TPL +A  R  ++ VK+LLD
Sbjct: 230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289

Query: 172 HNANID--IQNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
             A ID   ++G    +   +S H     M L R A   L + ++G +PLH++   D + 
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI-LSKTKNGLSPLHMATQGDHLN 348

Query: 229 CARML--YNYGADTNTRNY 245
           C ++L  +N   D  T +Y
Sbjct: 349 CVQLLLQHNVPVDDVTNDY 367



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 67/240 (27%), Positives = 111/240 (46%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G+ + V+ +L++G   + +  +G T LH  A  G E+ V + L+  A P +  
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA-PILSK 330

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G + LH A         +L+L+     D +   +ND  T LHVAAH G     ++LL
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV---TNDYLTALHVAAHCGHYKVAKVLL 387

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFL-LRYAVIKSNHS 194
           + KA  +  +  G TPL +A  + R   +++LL H A+I    ++G   +  A    + +
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                +  GA  N   +  G+T LH++A        R L   GA    +  + QTPL +S
Sbjct: 448 IVSQLMHHGASPNTTNVR-GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506



 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 64/237 (27%), Positives = 112/237 (47%), Gaps = 12/237 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L++  + +     G T LH ++  G+   V+V + +GA+   + 
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +L++     +    + DG+TPL VA   G D  V LLL
Sbjct: 138 Q-NGFTPLYMAAQENHLEVVKFLLDNGASQSLA---TEDGFTPLAVALQQGHDQVVSLLL 193

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--DHNANIDIQNGFL-LRYAVIKSNHS 194
           E     D         L +A  ++ +    +LL  D+NA+++ ++GF  L  A    N +
Sbjct: 194 EN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + L R A  +     D  TPLH+++ R +    ++L + GA  + +  +G TPL
Sbjct: 250 VATLLLNRAAAVDFTARND-ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 52/175 (29%), Positives = 78/175 (44%), Gaps = 35/175 (20%)

Query: 33  MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPT------------------ 74
           +L+QG SP+    NG+T LH +A + +       LE+GAD                    
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676

Query: 75  ---VKDLIG-----------GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
              V  L+G           G T LH AA   R  +A +++      D   A++  G+TP
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD---AQTKMGYTP 733

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175
           LHV  HYG    V  LL+  A+V+  +  G TPL  A  +  +  + +LL +NA+
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 50/177 (28%), Positives = 78/177 (44%), Gaps = 33/177 (18%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL+ +A VD  + KG T L +A +  ++  VK+L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 170 LDHNANIDI--QNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTP--------- 217
           + + AN++   QNGF   Y   + NH    +  L  GA  +L   EDG TP         
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA-TEDGFTPLAVALQQGH 185

Query: 218 --------------------LHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                               LH++A +DD   A +L     + +  +  G TPL ++
Sbjct: 186 DQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242



 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 4/140 (2%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V  +L +  + N  + +G T LH +A   +     V +  GA    + 
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +G +T LH    +G  +I   +L+   +   +NAK+ +G+TPLH AA  G    + +LL
Sbjct: 728 KMG-YTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLL 783

Query: 138 EFKAEVDPLSDKGTTPLQLA 157
           +  A  + L+  G T L +A
Sbjct: 784 QNNASPNELTVNGNTALGIA 803


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  112 bits (279), Expect = 5e-25
 Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)

Query: 13  QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
           +E+  +  A   G    V+ +L+    P+    NG+T LH SA  G+     V LE GA 
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534

Query: 73  PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
            ++     GFT LH AA +G   +A+L+L+    +D   +   +G TPLHVAAHY     
Sbjct: 535 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 590

Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
             LLLE  A     +  G TPL +A  + +      LL++ A  NI  + G    +   +
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650

Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
             H+    + L +GA+ ++   + G T LHL+A  D V  A +L  +GAD +     G T
Sbjct: 651 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709

Query: 250 PLAVS 254
           PL V+
Sbjct: 710 PLIVA 714



 Score =  107 bits (268), Expect = 9e-24
 Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + +    +G+T L  +  +G  + V + LE+     V+    
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 171

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
              ALH AA     + A L+L++++ +D+     +N  +  G+TPLH+AAHYG  +   L
Sbjct: 172 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
           LL   A VD  +  G TPL +A  R  ++ VK+LLD    ID   ++G    +   +S H
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290

Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
                + L+RGA   L R ++G +PLH++A  D V C + L  + A  +    +  T L 
Sbjct: 291 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 349

Query: 253 VS 254
           V+
Sbjct: 350 VA 351



 Score =  104 bits (260), Expect = 7e-23
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)

Query: 12  LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
           ++ E  +  A  AG V  VR +L  G   + R     T LH ++  GK   V++ L+H A
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500

Query: 72  DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
            P       G+T LH +A  G+  +A ++LE+     +   K   G+TPLHVAA YG   
Sbjct: 501 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 556

Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
             +LLL+ +A  D     G TPL +A                A+ D              
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 586

Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           N     + L++GA  +    ++G TPLH++A ++ +  A  L NYGA+TN    +G TPL
Sbjct: 587 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645



 Score = 98.2 bits (243), Expect = 7e-21
 Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A  +G    V  +LE+G     R  NG + LH +A      CV+  L+H A P    
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 340

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   TALH AA  G  R+ +L+L+        NA++ +G+TPLH+A    R   + LL+
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 397

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
           ++ A +  +++ G TP+ +A      + V +LL + A+ D+ N      L  A       
Sbjct: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             R  L+ GA  +  R  + QTPLH+++        ++L  + A  +     G TPL +S
Sbjct: 458 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 516



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 67/242 (27%), Positives = 114/242 (47%), Gaps = 12/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
           +  A   G +   + +L++  + +    NG T LH +A    ++   + LE GA P  T 
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           K+   G+T LH AA   + +IA  +L     ++I+   +  G TPLH+A+  G    V L
Sbjct: 606 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 659

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
           LL+  A +   +  G T L LA   ++ +   IL  H A+ D          ++  ++  
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 719

Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
            +M    L++GA+ N  + ++G TPLH +A +       +L  +GA  N     G T LA
Sbjct: 720 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 778

Query: 253 VS 254
           ++
Sbjct: 779 IA 780



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
           A  AG++  V + L+ G   N  + NG   LH +A  G    V+  L  G+  D   K  
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 75

Query: 79  IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
             G TALH A++ G+A + +++++       INA+S +G+TPL++AA       V+ LLE
Sbjct: 76  --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
             A     ++ G TPL +A+ +  +  V ILL+++    ++    L  A  K +     +
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 189

Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
            LQ   + ++          E G TPLH++A   +V  A +L N GA  +     G TPL
Sbjct: 190 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 249

Query: 252 AVS 254
            V+
Sbjct: 250 HVA 252



 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V+++L +G S +     G T LH ++  G+   V+V ++ GA+   + 
Sbjct: 47  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       +  + DG+TPL VA   G +  V +LL
Sbjct: 107 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 162

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
               E D         L +A  ++ +    +LL ++ N D+Q+  +           L  
Sbjct: 163 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218

Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
           A    N +   + L RGA  +     +G TPLH+++ R +    ++L + G   + +  +
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277

Query: 247 GQTPL 251
           G TPL
Sbjct: 278 GLTPL 282



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+AA  G    V+ LL   + VD  + KG T L +A +  ++  VK+L
Sbjct: 36  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +   ANI+ Q+                               ++G TPL+++A  + +  
Sbjct: 96  VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 124

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ +T   +G TPLAV++
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVAL 150


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  112 bits (279), Expect = 5e-25
 Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)

Query: 13  QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
           +E+  +  A   G    V+ +L+    P+    NG+T LH SA  G+     V LE GA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 73  PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
            ++     GFT LH AA +G   +A+L+L+    +D   +   +G TPLHVAAHY     
Sbjct: 556 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 611

Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
             LLLE  A     +  G TPL +A  + +      LL++ A  NI  + G    +   +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
             H+    + L +GA+ ++   + G T LHL+A  D V  A +L  +GAD +     G T
Sbjct: 672 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 250 PLAVS 254
           PL V+
Sbjct: 731 PLIVA 735



 Score =  107 bits (268), Expect = 9e-24
 Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + +    +G+T L  +  +G  + V + LE+     V+    
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 192

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
              ALH AA     + A L+L++++ +D+     +N  +  G+TPLH+AAHYG  +   L
Sbjct: 193 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
           LL   A VD  +  G TPL +A  R  ++ VK+LLD    ID   ++G    +   +S H
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
                + L+RGA   L R ++G +PLH++A  D V C + L  + A  +    +  T L 
Sbjct: 312 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 253 VS 254
           V+
Sbjct: 371 VA 372



 Score =  104 bits (260), Expect = 7e-23
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)

Query: 12  LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
           ++ E  +  A  AG V  VR +L  G   + R     T LH ++  GK   V++ L+H A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 72  DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
            P       G+T LH +A  G+  +A ++LE+     +   K   G+TPLHVAA YG   
Sbjct: 522 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 577

Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
             +LLL+ +A  D     G TPL +A                A+ D              
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 607

Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           N     + L++GA  +    ++G TPLH++A ++ +  A  L NYGA+TN    +G TPL
Sbjct: 608 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666



 Score = 98.2 bits (243), Expect = 7e-21
 Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A  +G    V  +LE+G     R  NG + LH +A      CV+  L+H A P    
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 361

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   TALH AA  G  R+ +L+L+        NA++ +G+TPLH+A    R   + LL+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 418

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
           ++ A +  +++ G TP+ +A      + V +LL + A+ D+ N      L  A       
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             R  L+ GA  +  R  + QTPLH+++        ++L  + A  +     G TPL +S
Sbjct: 479 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 67/242 (27%), Positives = 114/242 (47%), Gaps = 12/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
           +  A   G +   + +L++  + +    NG T LH +A    ++   + LE GA P  T 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           K+   G+T LH AA   + +IA  +L     ++I+   +  G TPLH+A+  G    V L
Sbjct: 627 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 680

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
           LL+  A +   +  G T L LA   ++ +   IL  H A+ D          ++  ++  
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740

Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
            +M    L++GA+ N  + ++G TPLH +A +       +L  +GA  N     G T LA
Sbjct: 741 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799

Query: 253 VS 254
           ++
Sbjct: 800 IA 801



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
           A  AG++  V + L+ G   N  + NG   LH +A  G    V+  L  G+  D   K  
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 96

Query: 79  IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
             G TALH A++ G+A + +++++       INA+S +G+TPL++AA       V+ LLE
Sbjct: 97  --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
             A     ++ G TPL +A+ +  +  V ILL+++    ++    L  A  K +     +
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 210

Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
            LQ   + ++          E G TPLH++A   +V  A +L N GA  +     G TPL
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270

Query: 252 AVS 254
            V+
Sbjct: 271 HVA 273



 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V+++L +G S +     G T LH ++  G+   V+V ++ GA+   + 
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       +  + DG+TPL VA   G +  V +LL
Sbjct: 128 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 183

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
               E D         L +A  ++ +    +LL ++ N D+Q+  +           L  
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
           A    N +   + L RGA  +     +G TPLH+++ R +    ++L + G   + +  +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 247 GQTPL 251
           G TPL
Sbjct: 299 GLTPL 303



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+AA  G    V+ LL   + VD  + KG T L +A +  ++  VK+L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +   ANI+ Q+                               ++G TPL+++A  + +  
Sbjct: 117 VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 145

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ +T   +G TPLAV++
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVAL 171


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  112 bits (279), Expect = 5e-25
 Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)

Query: 13  QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
           +E+  +  A   G    V+ +L+    P+    NG+T LH SA  G+     V LE GA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 73  PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
            ++     GFT LH AA +G   +A+L+L+    +D   +   +G TPLHVAAHY     
Sbjct: 556 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 611

Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
             LLLE  A     +  G TPL +A  + +      LL++ A  NI  + G    +   +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
             H+    + L +GA+ ++   + G T LHL+A  D V  A +L  +GAD +     G T
Sbjct: 672 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 250 PLAVS 254
           PL V+
Sbjct: 731 PLIVA 735



 Score =  107 bits (268), Expect = 9e-24
 Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + +    +G+T L  +  +G  + V + LE+     V+    
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 192

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
              ALH AA     + A L+L++++ +D+     +N  +  G+TPLH+AAHYG  +   L
Sbjct: 193 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
           LL   A VD  +  G TPL +A  R  ++ VK+LLD    ID   ++G    +   +S H
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
                + L+RGA   L R ++G +PLH++A  D V C + L  + A  +    +  T L 
Sbjct: 312 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 253 VS 254
           V+
Sbjct: 371 VA 372



 Score =  104 bits (260), Expect = 7e-23
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)

Query: 12  LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
           ++ E  +  A  AG V  VR +L  G   + R     T LH ++  GK   V++ L+H A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 72  DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
            P       G+T LH +A  G+  +A ++LE+     +   K   G+TPLHVAA YG   
Sbjct: 522 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 577

Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
             +LLL+ +A  D     G TPL +A                A+ D              
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 607

Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           N     + L++GA  +    ++G TPLH++A ++ +  A  L NYGA+TN    +G TPL
Sbjct: 608 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666



 Score = 98.2 bits (243), Expect = 7e-21
 Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A  +G    V  +LE+G     R  NG + LH +A      CV+  L+H A P    
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 361

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   TALH AA  G  R+ +L+L+        NA++ +G+TPLH+A    R   + LL+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 418

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
           ++ A +  +++ G TP+ +A      + V +LL + A+ D+ N      L  A       
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             R  L+ GA  +  R  + QTPLH+++        ++L  + A  +     G TPL +S
Sbjct: 479 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 67/242 (27%), Positives = 114/242 (47%), Gaps = 12/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
           +  A   G +   + +L++  + +    NG T LH +A    ++   + LE GA P  T 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           K+   G+T LH AA   + +IA  +L     ++I+   +  G TPLH+A+  G    V L
Sbjct: 627 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 680

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
           LL+  A +   +  G T L LA   ++ +   IL  H A+ D          ++  ++  
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740

Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
            +M    L++GA+ N  + ++G TPLH +A +       +L  +GA  N     G T LA
Sbjct: 741 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799

Query: 253 VS 254
           ++
Sbjct: 800 IA 801



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
           A  AG++  V + L+ G   N  + NG   LH +A  G    V+  L  G+  D   K  
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 96

Query: 79  IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
             G TALH A++ G+A + +++++       INA+S +G+TPL++AA       V+ LLE
Sbjct: 97  --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
             A     ++ G TPL +A+ +  +  V ILL+++    ++    L  A  K +     +
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 210

Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
            LQ   + ++          E G TPLH++A   +V  A +L N GA  +     G TPL
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270

Query: 252 AVS 254
            V+
Sbjct: 271 HVA 273



 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V+++L +G S +     G T LH ++  G+   V+V ++ GA+   + 
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       +  + DG+TPL VA   G +  V +LL
Sbjct: 128 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 183

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
               E D         L +A  ++ +    +LL ++ N D+Q+  +           L  
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
           A    N +   + L RGA  +     +G TPLH+++ R +    ++L + G   + +  +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 247 GQTPL 251
           G TPL
Sbjct: 299 GLTPL 303



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+AA  G    V+ LL   + VD  + KG T L +A +  ++  VK+L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +   ANI+ Q+                               ++G TPL+++A  + +  
Sbjct: 117 VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 145

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ +T   +G TPLAV++
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVAL 171


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  106 bits (264), Expect = 2e-23
 Identities = 79/245 (32%), Positives = 120/245 (48%), Gaps = 10/245 (4%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A+ +GD   + K+L+        D+ G +LLH +   G+E C +  L + A+P + +  G
Sbjct: 413 AIVSGDTSKLMKILQPQDVDLALDS-GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
             T LH A       +  L+L    R   +NAK  D WT LH AA  G +S  RLLLE  
Sbjct: 472 S-TPLHMAVERRVRGVVELLLA---RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHSYCR 197
           A V+ +  +G TP+ +A    + + V+ILL    ++ +Q       L YA  + +    +
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 198 MFL-QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           +   Q G   N   L DG+TPLHL+A R     AR+L +  +D N  +   QTPL V+  
Sbjct: 588 LLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646

Query: 257 ISGSS 261
              +S
Sbjct: 647 TGHTS 651



 Score = 95.1 bits (235), Expect = 6e-20
 Identities = 72/226 (31%), Positives = 103/226 (45%), Gaps = 9/226 (3%)

Query: 30  VRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAA 89
           V  +L +  S N +D + WT LHF+A  G E   R+ LE  A     D  G  T +H A 
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR-TPMHVAC 545

Query: 90  MHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKA-EVDPLSD 148
            HG+  I R++L    R   ++ +  D W PLH AA  G    V+LL +     V+  + 
Sbjct: 546 QHGQENIVRILLR---RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL 602

Query: 149 KGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGAD 205
            G TPL LA  R      +IL+D  +++++ +      L  A    + S  R+ L RGA 
Sbjct: 603 DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662

Query: 206 TNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
                  DG T LHL+A    +   ++L    AD   R    QT L
Sbjct: 663 KE-AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 63/205 (30%), Positives = 103/205 (50%), Gaps = 7/205 (3%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A   GD  + R +LE+  S N  D  G T +H +   G+E  VR+ L  G D +++    
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK-D 569

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
            +  LHYAA  G   I +L+ +    S  +NA++ DG TPLH+AA  G     R+L++  
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH-SYCR 197
           ++V+  S    TPL +A     +S  ++LL   A  +    +G+   +   ++ H +  +
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVK 687

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSA 222
           + ++  AD  L R    QT LHL+A
Sbjct: 688 LLVEEKADV-LARGPLNQTALHLAA 711



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 66/233 (28%), Positives = 109/233 (46%), Gaps = 6/233 (2%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G  + VR +L +G   + +  + W  LH++A +G    V++  +         
Sbjct: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            + G T LH AA  G  R+AR+++  +  SD +N  S    TPLHVAA  G  S  RLLL
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILI--DLCSD-VNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAV-IKSNHSYC 196
              A  + ++  G T L LA      + VK+L++  A++ +  G L + A+ + + H + 
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADV-LARGPLNQTALHLAAAHGHS 716

Query: 197 RMFLQR-GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQ 248
            +  +   AD      E G + LHL+A          L  +GA  N ++ + Q
Sbjct: 717 EVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 5/133 (3%)

Query: 12  LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
           L  +  +  A   G   T R +L +G       ++G+T LH +A  G    V++ +E  A
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694

Query: 72  DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
           D   +  +   TALH AA HG + +    +E    +D+I+     G + LH+AA      
Sbjct: 695 DVLARGPLNQ-TALHLAAAHGHSEV----VEELVSADVIDLFDEQGLSALHLAAQGRHAQ 749

Query: 132 FVRLLLEFKAEVD 144
            V  LL   A ++
Sbjct: 750 TVETLLRHGAHIN 762


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/271 (27%), Positives = 128/271 (47%), Gaps = 36/271 (13%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  AVA+     V+ +++     N RD N  T LH +AA    +C  V +   +   V D
Sbjct: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112

Query: 78  LIGGFTALHYAAMHGRARIARLMLE------------------SEYRSDI---------- 109
             GG TALH+AA++G   +  L+L                   + Y   +          
Sbjct: 113 R-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171

Query: 110 --INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVK 167
             +  K   G+TPLH AA  G+ + V+ LL    E+D ++  G T L +A    + + V 
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231

Query: 168 ILLDHNANID--IQNGFL-LRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSAL 223
            L+D+ AN++    NGF  L +A   ++ + C  + +  GAD N+ + +DG++PLH++A+
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI-QSKDGKSPLHMTAV 290

Query: 224 RDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                 ++ L   G + +  + +G TPL V+
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321



 Score = 91.7 bits (226), Expect = 6e-19
 Identities = 68/231 (29%), Positives = 108/231 (46%), Gaps = 9/231 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER-CVRVFLEHGADPTVKDLIGGFT 83
           G    V ++++ G + N  + NG+T LHF+AA      C+ + + +GAD  ++    G +
Sbjct: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK-DGKS 283

Query: 84  ALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV 143
            LH  A+HGR   ++ ++++    D ++    DG TPLHVAA YG +  +  L    A+ 
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVD---KDGNTPLHVAARYGHELLINTLRTSGADT 340

Query: 144 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFL 200
                    PL LA +   S C + LL     ID  + F    L  A    N    ++  
Sbjct: 341 AKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQ 400

Query: 201 QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
             GAD +  + + G+TPLH +A      C   L   GA+ N  +  G+T L
Sbjct: 401 SSGADFH-KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 70/237 (29%), Positives = 101/237 (42%), Gaps = 31/237 (13%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  AVA G +  V  +LE+  + +  D  G T LH     G E CV++ LE       KD
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
             G  T LHYAA  G A     +L+     +    K N G+TPLH A + G ++ + +LL
Sbjct: 709 SRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR 197
           E K           TPL  AII +  +C  +LL                  I S+   CR
Sbjct: 768 EQKC-FRKFIGNPFTPLHCAIINDHGNCASLLL----------------GAIDSSIVSCR 810

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                         + G+TPL  +A  D V C ++L  + A  N  +  G+T L ++
Sbjct: 811 D-------------DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 61/196 (31%), Positives = 89/196 (45%), Gaps = 5/196 (2%)

Query: 43  RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLE 102
           RD  G T L  +A +G   CV   +  GA   VKD +   T LH + ++G     RL+LE
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630

Query: 103 SEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRER 162
                + ++ K   G TPL +A  YG    V LLLE +A VD +   G T L   I+   
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690

Query: 163 SSCVKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLED--GQTP 217
             CV++LL+   +I   D +    L YA  + + ++    LQ          +D  G TP
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750

Query: 218 LHLSALRDDVLCARML 233
           LH +    +  C  +L
Sbjct: 751 LHWACYNGNENCIEVL 766



 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 75/299 (25%), Positives = 132/299 (44%), Gaps = 45/299 (15%)

Query: 6   CRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER---- 61
           C R P       +  A A    H +  ++  G + N  D  G T LH++AA   +R    
Sbjct: 412 CGRTP-------LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464

Query: 62  ------------------------CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
                                   C+   L++ A+P+++D   G+ ++HYAA +G  +  
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDK-EGYNSIHYAAAYGHRQCL 523

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
            L+LE    S    + S    +PLH+AA+ G    + +LL+   ++D   +KG T L LA
Sbjct: 524 ELLLERT-NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582

Query: 158 IIRERSSCVKILLDHNANIDIQNGFLLR---YAVIKSNHSYC-RMFLQRGADTNLGRLED 213
             +  + CV+ L++  A+I +++    R   +A + + H+ C R+ L+   +     ++D
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642

Query: 214 --GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQE 270
             GQTPL L+     +    +L    A+ +T +  G T  A+   I      C+  L E
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT--ALHRGIMTGHEECVQMLLE 699



 Score = 78.6 bits (192), Expect = 6e-15
 Identities = 71/272 (26%), Positives = 115/272 (42%), Gaps = 34/272 (12%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           + AA A G+V  ++ +   G   + +D  G T LH++AA     C+   +  GA+    D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443

Query: 78  LIGGFTALHYAAMHG------------------------RARIARLMLESEYRSDI-INA 112
              G TALHYAA                           + + A L LE   ++D   + 
Sbjct: 444 -DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSI 502

Query: 113 KSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTT--PLQLAIIRERSSCVKILL 170
           +  +G+  +H AA YG    + LLLE        SD G T  PL LA        +++LL
Sbjct: 503 RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562

Query: 171 DHNANIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
               ++DI++      L  A  K +       +  GA   +      +TPLH S +    
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622

Query: 228 LCARMLYNYGAD---TNTRNYEGQTPLAVSIS 256
           LC R+L     +    + ++ +GQTPL ++++
Sbjct: 623 LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654



 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 48/177 (27%), Positives = 87/177 (49%), Gaps = 7/177 (3%)

Query: 83  TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
           T LH AA  G A I  L++ S  R   +NAK N   TPLH A     +  V++L++  A+
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGAR---VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74

Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNG---FLLRYAVIKSNHSYCRMF 199
           V+       TPL +A   +   C ++++   +++++ +      L +A +  +     + 
Sbjct: 75  VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134

Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           L +GA+ N    +D +  LH +A    +    +L N+GA+   ++ +G TPL  + S
Sbjct: 135 LAKGANINAFDKKDRRA-LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 54/196 (27%), Positives = 91/196 (46%), Gaps = 12/196 (6%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNG---RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           A A G    + ++L+   S      +D  G+T LH++   G E C+ V LE       + 
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC---FRK 774

Query: 78  LIGG-FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
            IG  FT LH A ++     A L+L +   S I++ + + G TPL  AA       ++LL
Sbjct: 775 FIGNPFTPLHCAIINDHGNCASLLLGA-IDSSIVSCRDDKGRTPLRAAAFADHVECLQLL 833

Query: 137 LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH-NANIDIQNGFL---LRYAVIKSN 192
           L   A V+ + + G T L +A    ++  V IL++   A++ +++  L   L  A  K +
Sbjct: 834 LRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893

Query: 193 HSYCRMFLQRGADTNL 208
                + L +  D +L
Sbjct: 894 EKCALLILDKIQDESL 909



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 31/99 (31%), Positives = 46/99 (46%), Gaps = 2/99 (2%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG-ADPTVK 76
           ++AA  A  V  ++ +L      N  D +G T L  +A  G+   V + +    AD TVK
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877

Query: 77  DLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSN 115
           D     T LH A   G  + A L+L+      +IN K+N
Sbjct: 878 DKDLN-TPLHLACSKGHEKCALLILDKIQDESLINEKNN 915


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)

Query: 26  DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           +++  + +L +G S N    NG T LH ++ RG    VR+ L+ GA    K      T L
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 309

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA +G  RI+ ++L+       I AK+ +G +P+H+AA       VRLLL++ AE+D 
Sbjct: 310 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
           ++    TPL +A         K+LLD  A  N    NGF   +   K NH     + L+ 
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           GA  +    E G TPLH+++    +   + L   GA  N  N + +TPL
Sbjct: 427 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474



 Score =  100 bits (250), Expect = 1e-21
 Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           ++  +  A   G  + V+ +LE   +PN     G T LH +A  G    V   LE  A  
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
                  GFT LH AA +G+ R+A L+LE +      NA   +G TPLHVA H+     V
Sbjct: 563 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 618

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
           +LLL         +  G TPL +A  + +    + LL +  +AN +   G    +   + 
Sbjct: 619 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678

Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
            H+    + L + A+ NLG  + G TPLHL A    V  A +L  +G   +     G TP
Sbjct: 679 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 737

Query: 251 LAVS 254
           L V+
Sbjct: 738 LHVA 741



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + N    +G+T L  +  +G E  V   + +G    V+    
Sbjct: 151 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 206

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
              ALH AA +   R A ++L+++   D++   S  G+TPLH+AAHY   +  +LLL   
Sbjct: 207 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 262

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
           A V+     G TPL +A  R     V++LLD  A I+ +    L      + + + R   
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           + L  GA     + ++G +P+H++A  D + C R+L  Y A+ +    +  TPL V+
Sbjct: 323 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
           +  A   G     + +L++G  PN R  NG+T LH +  +   R + + L+ GA  D   
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +    G T LH A+  G   I + +L+     ++ N K     TPLH+AA  G     + 
Sbjct: 435 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 488

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
           LL+ KA+V+  +    TPL  A     ++ VK+LL++NAN ++    G    +   +  H
Sbjct: 489 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
               + L     +     + G TPLH++A    V  A +L    A  N     G TPL V
Sbjct: 549 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608

Query: 254 SI 255
           ++
Sbjct: 609 AV 610



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A     V  +  +L+ G S +    +G T LH ++  G    V+  L+ GA P V +
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   T LH AA  G   +A+ +L+++ +   +NAK+ D  TPLH AA  G  + V+LLL
Sbjct: 468 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 523

Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
           E  A  +  +  G TPL            LA++ + +S                      
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583

Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
             ++LL+ +A  N   +NG   L  AV  +N    ++ L RG   +     +G TPLH++
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 642

Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           A ++ V  AR L  YG   N  + +G TPL
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPL 672



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V     +LE+   PN    NG T LH +        V++ L  G  P    
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 631

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G+T LH AA   +  +AR +L+        NA+S  G TPLH+AA  G    V LLL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 688

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
             +A  +  +  G TPL L           +L+ H   +D     G+  L  A    N  
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             +  LQ  AD N  + + G +PLH +A +       +L   GA  N  + +G TPLA++
Sbjct: 749 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V TV  +LE+  S       G+T LH +A  GK R   + LE  A P    
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G T LH A  H    I +L+L    R    ++ + +G+TPLH+AA   +    R LL
Sbjct: 600 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
           ++    +  S +G TPL LA     +  V +LL   AN ++ N  G    + V +  H  
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + ++ G   +      G TPLH+++   ++   + L  + AD N +   G +PL
Sbjct: 716 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 771



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           LH +A     R   V L++  +P V    G FT LH AA +    +A+L+L    R   +
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 265

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N    +G TPLH+A+  G    VRLLL+  A+++  +    TPL  A         +ILL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325

Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           DH A I  +  NG    +   + +H  C R+ LQ  A+ +   L D  TPLH++A     
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 384

Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
             A++L + GA  N+R   G TPL ++
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIA 411



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L +          G T LH +A  G++  VR  + +GA+   + 
Sbjct: 82  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       N  + DG+TPL VA   G ++ V  L+
Sbjct: 142 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 197

Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
            +  +      K   P L +A   + +    +LL ++ N D+  + GF  L  A    N 
Sbjct: 198 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +  ++ L RGA  N    ++G TPLH+++ R +V+  R+L + GA   T+  +  TPL
Sbjct: 253 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309



 Score = 71.2 bits (173), Expect = 9e-13
 Identities = 57/205 (27%), Positives = 87/205 (42%), Gaps = 34/205 (16%)

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
           G   LH A+  G  ++   +L  E    I+   +  G T LH+AA  G+D  VR L+ + 
Sbjct: 78  GLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRM 198
           A V+  S KG TPL +A        VK LL++  N N+  ++GF      ++  H     
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 194

Query: 199 FL-----------------QRGADTNLGRL------------EDGQTPLHLSALRDDVLC 229
            L                  R  DT    +            + G TPLH++A  +++  
Sbjct: 195 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 254

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVS 254
           A++L N GA  N     G TPL ++
Sbjct: 255 AQLLLNRGASVNFTPQNGITPLHIA 279



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 40/137 (29%), Positives = 66/137 (48%), Gaps = 4/137 (2%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL  +  ++  + KG T L +A +  +   V+ L
Sbjct: 71  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130

Query: 170 LDHNANIDIQN--GFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDD 226
           +++ AN++ Q+  GF   Y   + NH    +  L+ GA+ N+   EDG TPL ++  +  
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA-TEDGFTPLAVALQQGH 189

Query: 227 VLCARMLYNYGADTNTR 243
                 L NYG     R
Sbjct: 190 ENVVAHLINYGTKGKVR 206



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
           G V     +++ G   +     G+T LH ++  G  + V+  L+H AD   K  +G ++ 
Sbjct: 712 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 770

Query: 85  LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
           LH AA  G   I  L+L++       N  S+DG TPL +A   G  S   +L
Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)

Query: 26  DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           +++  + +L +G S N    NG T LH ++ RG    VR+ L+ GA    K      T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA +G  RI+ ++L+       I AK+ +G +P+H+AA       VRLLL++ AE+D 
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
           ++    TPL +A         K+LLD  A  N    NGF   +   K NH     + L+ 
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           GA  +    E G TPLH+++    +   + L   GA  N  N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441



 Score =  100 bits (250), Expect = 1e-21
 Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           ++  +  A   G  + V+ +LE   +PN     G T LH +A  G    V   LE  A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
                  GFT LH AA +G+ R+A L+LE +      NA   +G TPLHVA H+     V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
           +LLL         +  G TPL +A  + +    + LL +  +AN +   G    +   + 
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645

Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
            H+    + L + A+ NLG  + G TPLHL A    V  A +L  +G   +     G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 251 LAVS 254
           L V+
Sbjct: 705 LHVA 708



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + N    +G+T L  +  +G E  V   + +G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
              ALH AA +   R A ++L+++   D++   S  G+TPLH+AAHY   +  +LLL   
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
           A V+     G TPL +A  R     V++LLD  A I+ +    L      + + + R   
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           + L  GA     + ++G +P+H++A  D + C R+L  Y A+ +    +  TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
           +  A   G     + +L++G  PN R  NG+T LH +  +   R + + L+ GA  D   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +    G T LH A+  G   I + +L+     ++ N K     TPLH+AA  G     + 
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
           LL+ KA+V+  +    TPL  A     ++ VK+LL++NAN ++    G    +   +  H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
               + L     +     + G TPLH++A    V  A +L    A  N     G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575

Query: 254 SI 255
           ++
Sbjct: 576 AV 577



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A     V  +  +L+ G S +    +G T LH ++  G    V+  L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   T LH AA  G   +A+ +L+++ +   +NAK+ D  TPLH AA  G  + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
           E  A  +  +  G TPL            LA++ + +S                      
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
             ++LL+ +A  N   +NG   L  AV  +N    ++ L RG   +     +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609

Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           A ++ V  AR L  YG   N  + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V     +LE+   PN    NG T LH +        V++ L  G  P    
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G+T LH AA   +  +AR +L+        NA+S  G TPLH+AA  G    V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
             +A  +  +  G TPL L           +L+ H   +D     G+  L  A    N  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             +  LQ  AD N  + + G +PLH +A +       +L   GA  N  + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V TV  +LE+  S       G+T LH +A  GK R   + LE  A P    
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G T LH A  H    I +L+L    R    ++ + +G+TPLH+AA   +    R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
           ++    +  S +G TPL LA     +  V +LL   AN ++ N  G    + V +  H  
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + ++ G   +      G TPLH+++   ++   + L  + AD N +   G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           LH +A     R   V L++  +P V    G FT LH AA +    +A+L+L    R   +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N    +G TPLH+A+  G    VRLLL+  A+++  +    TPL  A         +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           DH A I  +  NG    +   + +H  C R+ LQ  A+ +   L D  TPLH++A     
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351

Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
             A++L + GA  N+R   G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L +          G T LH +A  G++  VR  + +GA+   + 
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       N  + DG+TPL VA   G ++ V  L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164

Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
            +  +      K   P L +A   + +    +LL ++ N D+  + GF  L  A    N 
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +  ++ L RGA  N    ++G TPLH+++ R +V+  R+L + GA   T+  +  TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 38  YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
           YS   R+A+  T    +A  G        L +G D    +   G   LH A+  G  ++ 
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
             +L  E    I+   +  G T LH+AA  G+D  VR L+ + A V+  S KG TPL +A
Sbjct: 62  VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118

Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
                   VK LL++  N N+  ++GF      ++  H      L               
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
              R  DT    +            + G TPLH++A  +++  A++L N GA  N     
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 247 GQTPLAVS 254
           G TPL ++
Sbjct: 239 GITPLHIA 246



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
           G V     +++ G   +     G+T LH ++  G  + V+  L+H AD   K  +G ++ 
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737

Query: 85  LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
           LH AA  G   I  L+L++       N  S+DG TPL +A   G  S   +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL  +  ++  + KG T L +A +  +   V+ L
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +++ AN++ Q+                               + G TPL+++A  + +  
Sbjct: 98  VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ N    +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)

Query: 26  DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           +++  + +L +G S N    NG T LH ++ RG    VR+ L+ GA    K      T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA +G  RI+ ++L+       I AK+ +G +P+H+AA       VRLLL++ AE+D 
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
           ++    TPL +A         K+LLD  A  N    NGF   +   K NH     + L+ 
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           GA  +    E G TPLH+++    +   + L   GA  N  N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441



 Score =  100 bits (250), Expect = 1e-21
 Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           ++  +  A   G  + V+ +LE   +PN     G T LH +A  G    V   LE  A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
                  GFT LH AA +G+ R+A L+LE +      NA   +G TPLHVA H+     V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
           +LLL         +  G TPL +A  + +    + LL +  +AN +   G    +   + 
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645

Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
            H+    + L + A+ NLG  + G TPLHL A    V  A +L  +G   +     G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 251 LAVS 254
           L V+
Sbjct: 705 LHVA 708



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + N    +G+T L  +  +G E  V   + +G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
              ALH AA +   R A ++L+++   D++   S  G+TPLH+AAHY   +  +LLL   
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
           A V+     G TPL +A  R     V++LLD  A I+ +    L      + + + R   
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           + L  GA     + ++G +P+H++A  D + C R+L  Y A+ +    +  TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
           +  A   G     + +L++G  PN R  NG+T LH +  +   R + + L+ GA  D   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +    G T LH A+  G   I + +L+     ++ N K     TPLH+AA  G     + 
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
           LL+ KA+V+  +    TPL  A     ++ VK+LL++NAN ++    G    +   +  H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
               + L     +     + G TPLH++A    V  A +L    A  N     G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575

Query: 254 SI 255
           ++
Sbjct: 576 AV 577



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A     V  +  +L+ G S +    +G T LH ++  G    V+  L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   T LH AA  G   +A+ +L+++ +   +NAK+ D  TPLH AA  G  + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
           E  A  +  +  G TPL            LA++ + +S                      
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
             ++LL+ +A  N   +NG   L  AV  +N    ++ L RG   +     +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609

Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           A ++ V  AR L  YG   N  + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V     +LE+   PN    NG T LH +        V++ L  G  P    
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G+T LH AA   +  +AR +L+        NA+S  G TPLH+AA  G    V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
             +A  +  +  G TPL L           +L+ H   +D     G+  L  A    N  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             +  LQ  AD N  + + G +PLH +A +       +L   GA  N  + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V TV  +LE+  S       G+T LH +A  GK R   + LE  A P    
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G T LH A  H    I +L+L    R    ++ + +G+TPLH+AA   +    R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
           ++    +  S +G TPL LA     +  V +LL   AN ++ N  G    + V +  H  
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + ++ G   +      G TPLH+++   ++   + L  + AD N +   G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           LH +A     R   V L++  +P V    G FT LH AA +    +A+L+L    R   +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N    +G TPLH+A+  G    VRLLL+  A+++  +    TPL  A         +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           DH A I  +  NG    +   + +H  C R+ LQ  A+ +   L D  TPLH++A     
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351

Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
             A++L + GA  N+R   G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L +          G T LH +A  G++  VR  + +GA+   + 
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       N  + DG+TPL VA   G ++ V  L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164

Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
            +  +      K   P L +A   + +    +LL ++ N D+  + GF  L  A    N 
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +  ++ L RGA  N    ++G TPLH+++ R +V+  R+L + GA   T+  +  TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 38  YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
           YS   R+A+  T    +A  G        L +G D    +   G   LH A+  G  ++ 
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
             +L  E    I+   +  G T LH+AA  G+D  VR L+ + A V+  S KG TPL +A
Sbjct: 62  VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118

Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
                   VK LL++  N N+  ++GF      ++  H      L               
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
              R  DT    +            + G TPLH++A  +++  A++L N GA  N     
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 247 GQTPLAVS 254
           G TPL ++
Sbjct: 239 GITPLHIA 246



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
           G V     +++ G   +     G+T LH ++  G  + V+  L+H AD   K  +G ++ 
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737

Query: 85  LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
           LH AA  G   I  L+L++       N  S+DG TPL +A   G  S   +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL  +  ++  + KG T L +A +  +   V+ L
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +++ AN++ Q+                               + G TPL+++A  + +  
Sbjct: 98  VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ N    +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)

Query: 26  DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           +++  + +L +G S N    NG T LH ++ RG    VR+ L+ GA    K      T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA +G  RI+ ++L+       I AK+ +G +P+H+AA       VRLLL++ AE+D 
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
           ++    TPL +A         K+LLD  A  N    NGF   +   K NH     + L+ 
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           GA  +    E G TPLH+++    +   + L   GA  N  N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441



 Score =  100 bits (250), Expect = 1e-21
 Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           ++  +  A   G  + V+ +LE   +PN     G T LH +A  G    V   LE  A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
                  GFT LH AA +G+ R+A L+LE +      NA   +G TPLHVA H+     V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
           +LLL         +  G TPL +A  + +    + LL +  +AN +   G    +   + 
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645

Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
            H+    + L + A+ NLG  + G TPLHL A    V  A +L  +G   +     G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 251 LAVS 254
           L V+
Sbjct: 705 LHVA 708



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + N    +G+T L  +  +G E  V   + +G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
              ALH AA +   R A ++L+++   D++   S  G+TPLH+AAHY   +  +LLL   
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
           A V+     G TPL +A  R     V++LLD  A I+ +    L      + + + R   
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           + L  GA     + ++G +P+H++A  D + C R+L  Y A+ +    +  TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
           +  A   G     + +L++G  PN R  NG+T LH +  +   R + + L+ GA  D   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +    G T LH A+  G   I + +L+     ++ N K     TPLH+AA  G     + 
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
           LL+ KA+V+  +    TPL  A     ++ VK+LL++NAN ++    G    +   +  H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
               + L     +     + G TPLH++A    V  A +L    A  N     G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575

Query: 254 SI 255
           ++
Sbjct: 576 AV 577



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A     V  +  +L+ G S +    +G T LH ++  G    V+  L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   T LH AA  G   +A+ +L+++ +   +NAK+ D  TPLH AA  G  + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
           E  A  +  +  G TPL            LA++ + +S                      
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
             ++LL+ +A  N   +NG   L  AV  +N    ++ L RG   +     +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609

Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           A ++ V  AR L  YG   N  + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V     +LE+   PN    NG T LH +        V++ L  G  P    
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G+T LH AA   +  +AR +L+        NA+S  G TPLH+AA  G    V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
             +A  +  +  G TPL L           +L+ H   +D     G+  L  A    N  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             +  LQ  AD N  + + G +PLH +A +       +L   GA  N  + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V TV  +LE+  S       G+T LH +A  GK R   + LE  A P    
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G T LH A  H    I +L+L    R    ++ + +G+TPLH+AA   +    R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
           ++    +  S +G TPL LA     +  V +LL   AN ++ N  G    + V +  H  
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + ++ G   +      G TPLH+++   ++   + L  + AD N +   G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           LH +A     R   V L++  +P V    G FT LH AA +    +A+L+L    R   +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N    +G TPLH+A+  G    VRLLL+  A+++  +    TPL  A         +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           DH A I  +  NG    +   + +H  C R+ LQ  A+ +   L D  TPLH++A     
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351

Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
             A++L + GA  N+R   G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L +          G T LH +A  G++  VR  + +GA+   + 
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       N  + DG+TPL VA   G ++ V  L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164

Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
            +  +      K   P L +A   + +    +LL ++ N D+  + GF  L  A    N 
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +  ++ L RGA  N    ++G TPLH+++ R +V+  R+L + GA   T+  +  TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 38  YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
           YS   R+A+  T    +A  G        L +G D    +   G   LH A+  G  ++ 
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
             +L  E    I+   +  G T LH+AA  G+D  VR L+ + A V+  S KG TPL +A
Sbjct: 62  VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118

Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
                   VK LL++  N N+  ++GF      ++  H      L               
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
              R  DT    +            + G TPLH++A  +++  A++L N GA  N     
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 247 GQTPLAVS 254
           G TPL ++
Sbjct: 239 GITPLHIA 246



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
           G V     +++ G   +     G+T LH ++  G  + V+  L+H AD   K  +G ++ 
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737

Query: 85  LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
           LH AA  G   I  L+L++       N  S+DG TPL +A   G  S   +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL  +  ++  + KG T L +A +  +   V+ L
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +++ AN++ Q+                               + G TPL+++A  + +  
Sbjct: 98  VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ N    +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  103 bits (257), Expect = 2e-22
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)

Query: 26  DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           +++  + +L +G S N    NG T LH ++ RG    VR+ L+ GA    K      T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA +G  RI+ ++L+       I AK+ +G +P+H+AA       VRLLL++ AE+D 
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
           ++    TPL +A         K+LLD  A  N    NGF   +   K NH     + L+ 
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           GA  +    E G TPLH+++    +   + L   GA  N  N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441



 Score =  100 bits (250), Expect = 1e-21
 Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           ++  +  A   G  + V+ +LE   +PN     G T LH +A  G    V   LE  A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
                  GFT LH AA +G+ R+A L+LE +      NA   +G TPLHVA H+     V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
           +LLL         +  G TPL +A  + +    + LL +  +AN +   G    +   + 
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645

Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
            H+    + L + A+ NLG  + G TPLHL A    V  A +L  +G   +     G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 251 LAVS 254
           L V+
Sbjct: 705 LHVA 708



 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A     +  V+ +LE G + N    +G+T L  +  +G E  V   + +G    V+    
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
              ALH AA +   R A ++L+++   D++   S  G+TPLH+AAHY   +  +LLL   
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
           A V+     G TPL +A  R     V++LLD  A I+ +    L      + + + R   
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           + L  GA     + ++G +P+H++A  D + C R+L  Y A+ +    +  TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
           +  A   G     + +L++G  PN R  NG+T LH +  +   R + + L+ GA  D   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +    G T LH A+  G   I + +L+     ++ N K     TPLH+AA  G     + 
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
           LL+ KA+V+  +    TPL  A     ++ VK+LL++NAN ++    G    +   +  H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
               + L     +     + G TPLH++A    V  A +L    A  N     G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575

Query: 254 SI 255
           ++
Sbjct: 576 AV 577



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A     V  +  +L+ G S +    +G T LH ++  G    V+  L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
            +   T LH AA  G   +A+ +L+++ +   +NAK+ D  TPLH AA  G  + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
           E  A  +  +  G TPL            LA++ + +S                      
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
             ++LL+ +A  N   +NG   L  AV  +N    ++ L RG   +     +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609

Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           A ++ V  AR L  YG   N  + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V     +LE+   PN    NG T LH +        V++ L  G  P    
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G+T LH AA   +  +AR +L+        NA+S  G TPLH+AA  G    V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
             +A  +  +  G TPL L           +L+ H   +D     G+  L  A    N  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
             +  LQ  AD N  + + G +PLH +A +       +L   GA  N  + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V TV  +LE+  S       G+T LH +A  GK R   + LE  A P    
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G T LH A  H    I +L+L    R    ++ + +G+TPLH+AA   +    R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
           ++    +  S +G TPL LA     +  V +LL   AN ++ N  G    + V +  H  
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              + ++ G   +      G TPLH+++   ++   + L  + AD N +   G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           LH +A     R   V L++  +P V    G FT LH AA +    +A+L+L    R   +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N    +G TPLH+A+  G    VRLLL+  A+++  +    TPL  A         +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           DH A I  +  NG    +   + +H  C R+ LQ  A+ +   L D  TPLH++A     
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351

Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
             A++L + GA  N+R   G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G V  V ++L +          G T LH +A  G++  VR  + +GA+   + 
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              GFT L+ AA      + + +LE+       N  + DG+TPL VA   G ++ V  L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164

Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
            +  +      K   P L +A   + +    +LL ++ N D+  + GF  L  A    N 
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +  ++ L RGA  N    ++G TPLH+++ R +V+  R+L + GA   T+  +  TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 38  YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
           YS   R+A+  T    +A  G        L +G D    +   G   LH A+  G  ++ 
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
             +L  E    I+   +  G T LH+AA  G+D  VR L+ + A V+  S KG TPL +A
Sbjct: 62  VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118

Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
                   VK LL++  N N+  ++GF      ++  H      L               
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
              R  DT    +            + G TPLH++A  +++  A++L N GA  N     
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 247 GQTPLAVS 254
           G TPL ++
Sbjct: 239 GITPLHIA 246



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)

Query: 25  GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
           G V     +++ G   +     G+T LH ++  G  + V+  L+H AD   K  +G ++ 
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737

Query: 85  LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
           LH AA  G   I  L+L++       N  S+DG TPL +A   G  S   +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN  + +G   LH+A+  G    V  LL  +  ++  + KG T L +A +  +   V+ L
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           +++ AN++ Q+                               + G TPL+++A  + +  
Sbjct: 98  VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126

Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
            + L   GA+ N    +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  102 bits (254), Expect = 4e-22
 Identities = 76/233 (32%), Positives = 113/233 (48%), Gaps = 8/233 (3%)

Query: 22  VAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGG 81
           VA G V  VR +L      + + A+G+T L  +A   +     + L HGAD    D   G
Sbjct: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDE-DG 428

Query: 82  FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKA 141
           +  LH+AA +G    ARL+L+       ++A+  +GWTPLH+AA    ++  RLL+  +A
Sbjct: 429 WAPLHFAAQNGDDGTARLLLD---HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA 485

Query: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL---LRYAVIKSNHSYCRM 198
           + +    +G TPL +A      S VK+L    A +D Q   L   L  AV +      + 
Sbjct: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545

Query: 199 FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
            L+ GA  +    + G  PLH +A R   L  +ML  YGA      ++G TPL
Sbjct: 546 LLKSGAVPD-ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597



 Score =  102 bits (253), Expect = 5e-22
 Identities = 72/241 (29%), Positives = 113/241 (46%), Gaps = 41/241 (17%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD---PT 74
           +  AV  G V  ++ +L+ G  P+  D +G+  LH +AARGK    ++ L +GA    PT
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590

Query: 75  VKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVR 134
            +    G+T LH AA  G   I  L+ ES      + A +   WTPLH+AA +G ++ V 
Sbjct: 591 HQ----GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEEAVVS 643

Query: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHS 194
            LL+  A+ +     G TPL LA+ R     V  LL+H+AN+  +N              
Sbjct: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-------------- 689

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                            + G TP HL+AL+ +    ++L   GA  + ++    TPL ++
Sbjct: 690 -----------------KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732

Query: 255 I 255
           +
Sbjct: 733 L 733



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/242 (29%), Positives = 108/242 (44%), Gaps = 10/242 (4%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A   GD  T R +L+ G   + ++  GWT LH +A    E   R+ +   ADP + +   
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE-AE 493

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
           G T LH AA  G   + +L+       D   A+  +  TPLH+A   G+   ++ LL+  
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELD---AQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI---QNGFLLRYAVIKSNHSYCR 197
           A  D L   G  PL  A  R +    K+LL + A++++   Q    L  A  K +     
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 198 MFLQRGADTNLGRL-EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           +  +  A  N+G L     TPLHL+A   +      L   GAD N     G TPL +++ 
Sbjct: 611 LLAESHA--NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668

Query: 257 IS 258
            S
Sbjct: 669 RS 670



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 4/160 (2%)

Query: 10  PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEH 69
           P  Q    +  A   G +  +  + E   +     A  WT LH +A  G+E  V   L+ 
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648

Query: 70  GADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGR 129
           GADP   +   G+T LH A           +LE       ++A++  GWTP H+AA  G 
Sbjct: 649 GADPNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHAN---VHARNKVGWTPAHLAALKGN 704

Query: 130 DSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
            + +++L+E  A++D       TPLQLA+   +   +  L
Sbjct: 705 TAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 47/139 (33%), Positives = 68/139 (48%), Gaps = 4/139 (2%)

Query: 119 TPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN--- 175
           TPLH     G    VRLLL  + +VD  +  G TPL +A   ++     +LL H A+   
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 176 IDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYN 235
           +D      L +A    +    R+ L  GA  +  +  +G TPLHL+A  +    AR+L +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVD-AQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 236 YGADTNTRNYEGQTPLAVS 254
             AD N    EG+TPL V+
Sbjct: 483 RQADPNLHEAEGKTPLHVA 501



 Score = 28.9 bits (63), Expect = 5.1
 Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 12/133 (9%)

Query: 129 RDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAV 188
           R  F+ + +E    +  L  +   P   A+ R+ S  + +      N DI    +     
Sbjct: 275 RPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELM----- 329

Query: 189 IKSNHSYCRMFLQRG-------ADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTN 241
              + +Y +  LQ          D  L   E+  TPLH    +  V   R+L  +  D +
Sbjct: 330 DSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVD 389

Query: 242 TRNYEGQTPLAVS 254
            +   G TPL ++
Sbjct: 390 CQTASGYTPLLIA 402


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  102 bits (253), Expect = 5e-22
 Identities = 77/263 (29%), Positives = 123/263 (46%), Gaps = 10/263 (3%)

Query: 10  PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER-CVRVFLE 68
           P       +  A   G    V ++++ G   N ++  G+T LHF+AA      C+ + + 
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294

Query: 69  HGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYG 128
           +GAD  +K    G T LH  A+HGR   ++ +++S     +I+ +  +G TPLH+AA YG
Sbjct: 295 NGADVNMKSK-DGKTPLHMTALHGRFSRSQTIIQS---GAVIDCEDKNGNTPLHIAARYG 350

Query: 129 RDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLR 185
            +  +  L+   A+       G  PL LA +   S C + LL    +ID  + F    L 
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410

Query: 186 YAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNY 245
            A    N     + L  GAD N  + + G++PLH +A   +  C   L   GA  N  + 
Sbjct: 411 AAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469

Query: 246 EGQTPLAVSISISGSSRPCLDFL 268
            G TPL  + + S +   CL++L
Sbjct: 470 RGCTPLHYA-ATSDTDGKCLEYL 491



 Score =  100 bits (249), Expect = 1e-21
 Identities = 69/236 (29%), Positives = 119/236 (50%), Gaps = 19/236 (8%)

Query: 33  MLEQGYSPNGRDANGWTLLHFSAARGKE-RCVRVFLEHGADPTVKDLIGGFTALHYAAMH 91
           ++  G S N  D  G T LH++A    + +C+   L + A+P ++D   G+ A+HY+A +
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK-QGYNAVHYSAAY 515

Query: 92  GRARIARLMLESEYRSDIINAKSNDGW----------TPLHVAAHYGRDSFVRLLLEFKA 141
           G  R+   ++ SE   D++   S              +PLH+AA++G    + +L++   
Sbjct: 516 GH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL 574

Query: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLR---YAVIKSNHSYC-R 197
           ++D  +  G TPL LA  +    CV +L++  A+I +++  L R   +A   + HS C R
Sbjct: 575 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634

Query: 198 MFLQRGADTNLGRLED--GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           + +      N   ++D  GQTPL LS L     C   L N GA+ + ++  G+T L
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL 690



 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 76/238 (31%), Positives = 106/238 (44%), Gaps = 9/238 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  AVA+     V+ +L+     N RD N  T LH +AA    +C    +   ++  V D
Sbjct: 78  LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G TALH+AA  G   + +L+L    R   INA        +H AA+ G    V+LL+
Sbjct: 138 R-AGRTALHHAAFSGHGEMVKLLLS---RGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHS 194
              AEV     K  TPL  A      S VK LLD   +++  N +    L  A       
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSAL-RDDVLCARMLYNYGADTNTRNYEGQTPL 251
                +  GA  N  + E G TPLH +A      LC  +L   GAD N ++ +G+TPL
Sbjct: 254 VVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 45/266 (16%)

Query: 3   HHHCRR----NPELQEELQIQ---------AAVAAGDVHTVRKMLEQGYSPNGRDANGWT 49
           H  C R    N E Q  + IQ          +V  G    V  +L +G + + +D  G T
Sbjct: 629 HSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRT 688

Query: 50  LLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDI 109
            LH  A  G E CV   L+HGA   ++D   G T +H +A  G   +   +L+S    D 
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRD-SRGRTPIHLSAACGHIGVLGALLQSAASMDA 747

Query: 110 INAKS-NDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
             A + N G+T LH A + G ++ V LLLE +           +PL  A+I +     ++
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLE-QEVFQKTEGNAFSPLHCAVINDNEGAAEM 806

Query: 169 LLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
           L+D            L  +++ +  S                   G+TPLH +A  D V 
Sbjct: 807 LID-----------TLGASIVNATDS------------------KGRTPLHAAAFTDHVE 837

Query: 229 CARMLYNYGADTNTRNYEGQTPLAVS 254
           C ++L ++ A  N+ +  G+TPL ++
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMA 863



 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 65/243 (26%), Positives = 114/243 (46%), Gaps = 13/243 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYS----PNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           I  + A G +  +  +L+   S    P   D +G+T LH++   G E CV + LE     
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
             +     F+ LH A ++     A +++++   + I+NA  + G TPLH AA       +
Sbjct: 783 KTEG--NAFSPLHCAVINDNEGAAEMLIDT-LGASIVNATDSKGRTPLHAAAFTDHVECL 839

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH-NANIDIQN---GFLLRYAVI 189
           +LLL   A+V+ +   G TPL +A    +++ V++L+   +A + +Q+      L  A  
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899

Query: 190 KSNHSYCRMFLQRGADTNLGRLEDG--QTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
           K + +   + L++  D NL    +   QTPLH++A     +  + L   GA     +  G
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959

Query: 248 QTP 250
            TP
Sbjct: 960 YTP 962



 Score = 68.9 bits (167), Expect = 4e-12
 Identities = 66/249 (26%), Positives = 103/249 (41%), Gaps = 40/249 (16%)

Query: 43  RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLE 102
           R+++G T L  +A +G   CV V +  GA   VKD I   T +H AA +G +   RL++ 
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638

Query: 103 SEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRER 162
           +    + ++ +  +G TPL ++   G    V  LL   A VD     G T L    +   
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698

Query: 163 SSCVKILLDHNANIDIQN-------------------GFLLRYA-------VIKSNHSYC 196
             CV  LL H A   +++                   G LL+ A           NH Y 
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758

Query: 197 RMF--LQRGADTNLGRLEDGQ----------TPLHLSALRDDVLCARMLYN-YGAD-TNT 242
            +      G +T +  L + +          +PLH + + D+   A ML +  GA   N 
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA 818

Query: 243 RNYEGQTPL 251
            + +G+TPL
Sbjct: 819 TDSKGRTPL 827



 Score = 68.2 bits (165), Expect = 8e-12
 Identities = 48/177 (27%), Positives = 86/177 (48%), Gaps = 7/177 (3%)

Query: 83  TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
           T LH AA  G A I  L++ S  R   +NAK +   TPLH A     +  V++LL+  A+
Sbjct: 43  TPLHAAAYLGDAEIIELLILSGAR---VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 99

Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMF 199
           V+       TPL +A   +   C + L+   +N+++ +      L +A    +    ++ 
Sbjct: 100 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159

Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           L RGA+ N    +D +  +H +A    +   ++L ++GA+   ++ +  TPL  + S
Sbjct: 160 LSRGANINAFDKKDRRA-IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 215



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 38/147 (25%), Positives = 63/147 (42%), Gaps = 31/147 (21%)

Query: 105 YRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSS 164
           ++ + +N + N+  TPLH AA+ G    + LL+   A V+    K  TPL  A+      
Sbjct: 29  FKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEE 88

Query: 165 CVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALR 224
            V++LL H+A+++                                R ++ QTPLH++A  
Sbjct: 89  AVQVLLKHSADVN-------------------------------ARDKNWQTPLHIAAAN 117

Query: 225 DDVLCARMLYNYGADTNTRNYEGQTPL 251
             V CA  L    ++ N  +  G+T L
Sbjct: 118 KAVKCAEALVPLLSNVNVSDRAGRTAL 144


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 82/245 (33%), Positives = 114/245 (46%), Gaps = 13/245 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           ++AA   G    V  +L+ G   N  D  G T L  +A  G    V   L+HGA+   +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707

Query: 78  LIGGFTALHYAAM-----HGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
            + G TAL  AA+      G A +  L+++   R   ++    DG TPL VAA+ G    
Sbjct: 708 -VDGRTALSVAALCVPASKGHASVVSLLID---RGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA---NIDIQNGFLLRYAVI 189
           V LLLE  A+VD   + G TPL  A     +S V  LL   A   +ID +   +L  A  
Sbjct: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823

Query: 190 KSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
           + N    R  L RG D N  R + G TPLH++A     L    L   GA TN  + +G+ 
Sbjct: 824 QGNVEVVRTLLDRGLDEN-HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 250 PLAVS 254
           P  ++
Sbjct: 883 PFILA 887



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 75/238 (31%), Positives = 108/238 (45%), Gaps = 10/238 (4%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A   G V  V  +LE G   +  D NG T L  +A+ G    V   L  GA     D  G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
             T L  A+  G   + R +L+   R    N + + GWTPLH+AA  G       L+E  
Sbjct: 815 R-TVLSIASAQGNVEVVRTLLD---RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF----LLRYAVIKSNHSYC 196
           A  + + + G  P  LA       CV+ILL++ +NID Q G+     LR A ++ +    
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID-QRGYDGRNALRVAALEGHRDIV 929

Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
            +    GAD N  +  DG+  L++ AL + +  A      GA+    + EG+T L VS
Sbjct: 930 ELLFSHGADVNC-KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS 986



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 66/235 (28%), Positives = 114/235 (48%), Gaps = 8/235 (3%)

Query: 20   AAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
            AA + G    V  +L  G + +  D+ G T+L  ++A+G    VR  L+ G D   +D  
Sbjct: 787  AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD-D 845

Query: 80   GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
             G+T LH AA  G   I   ++E   R++ I+   NDG  P  +A+  G    V++LLE 
Sbjct: 846  AGWTPLHMAAFEGHRLICEALIEQGARTNEID---NDGRIPFILASQEGHYDCVQILLEN 902

Query: 140  KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYC 196
            K+ +D     G   L++A +      V++L  H A+++ ++      L    +++  +  
Sbjct: 903  KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962

Query: 197  RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
              FL+ GA+      E G+T LH+S  +  +   ++L  Y AD N  + E ++ L
Sbjct: 963  EYFLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL 1016



 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 78/273 (28%), Positives = 118/273 (43%), Gaps = 44/273 (16%)

Query: 29  TVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD----------- 77
           ++R +L+ G S N  D+NG TLL  +A  G    V + +  GAD  ++D           
Sbjct: 527 SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586

Query: 78  ----------LIG-----------GFTALHYAAMHGRARIARLMLESEYRSDIINAKSND 116
                     LIG           G+TAL  AA  G   +   +L +  + D  +A S  
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR- 645

Query: 117 GWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI 176
             T L  AA  G +  V  LL+  AEV+   ++G T L  A        V+ LLDH A +
Sbjct: 646 --TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703

Query: 177 ---DIQNGFLLRYAVI-----KSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
              D+     L  A +     K + S   + + RGA+ +    +DG TPL ++A    V 
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVD 762

Query: 229 CARMLYNYGADTNTRNYEGQTPLAVSISISGSS 261
              +L   GAD +  +  G+TPL  + S+  +S
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 65/272 (23%), Positives = 112/272 (41%), Gaps = 39/272 (14%)

Query: 18   IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
            +  A A G+V  VR +L++G   N RD  GWT LH +A  G        +E GA     D
Sbjct: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877

Query: 78   LIG--------------------------------GFTALHYAAMHGRARIARLMLESEY 105
              G                                G  AL  AA+ G   I  L+    +
Sbjct: 878  NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS--H 935

Query: 106  RSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSC 165
             +D+ N K  DG   L++ A   + +     LE  A V+    +G T L ++  +     
Sbjct: 936  GADV-NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 166  VKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSA 222
            V++L+ ++A++   D +    L+ A  + +    ++ ++ GA  +      G T L ++A
Sbjct: 995  VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD-HTCNQGATALCIAA 1053

Query: 223  LRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
                +   ++L  +GAD N  +  G+T + V+
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 55/193 (28%), Positives = 87/193 (45%), Gaps = 6/193 (3%)

Query: 18   IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
            ++ A   G    V  +   G   N +DA+G   L+  A   +      FLE+GA+    D
Sbjct: 917  LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976

Query: 78   LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G  TALH +   G   + ++++   Y +D+ NA  N+  + L  AA  G    V+LL+
Sbjct: 977  AEGR-TALHVSCWQGHMEMVQVLIA--YHADV-NAADNEKRSALQSAAWQGHVKVVQLLI 1032

Query: 138  EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNHSY 195
            E  A VD   ++G T L +A        V++LL+H A  N   Q G        K+ HS 
Sbjct: 1033 EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ 1092

Query: 196  CRMFLQRGADTNL 208
                L++   ++L
Sbjct: 1093 IIKLLEKYGASSL 1105


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 81/286 (28%), Positives = 130/286 (45%), Gaps = 32/286 (11%)

Query: 14  EELQIQAAVAAGDVHTVRKMLEQG-------------YSPNGRDANGWTLLHFSAARGKE 60
           +E ++  AV A DV T +++L++               + N +D +G++ LH +A  G  
Sbjct: 3   KEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNT 62

Query: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
             + + LE  A   +KD   G   LHYAA  GR    +L+L++      +N  S++G  P
Sbjct: 63  ELISLLLEAQAAVDIKD-NKGMRPLHYAAWQGRKEPMKLVLKA---GSAVNIPSDEGHIP 118

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN------- 173
           LH+AA +G      +LL+ ++    + + G TPL LA    R   V++LL  N       
Sbjct: 119 LHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLE 178

Query: 174 ---ANIDIQNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
               +    NG    +   K+ H    R+ LQ G D N  R     T LH +AL      
Sbjct: 179 PRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN--RQTKSGTALHEAALCGKTEV 236

Query: 230 ARMLYNYGADTNTRNYEGQTPLAV--SISISGSSRPCLDFLQEVTS 273
            R+L + G + + RN   QT L +    + S +SR     L+E ++
Sbjct: 237 VRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASA 282


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 7/175 (4%)

Query: 83  TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
           TALH+A   G   I   +L+       +N K + GW+PLH+AA  GRD  V+ LL   A+
Sbjct: 42  TALHWACSAGHTEIVEFLLQLGVP---VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98

Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMF 199
           V+ ++  G TPL  A  + R     +LL+  AN D ++ +    +  A  K N     + 
Sbjct: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158

Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           L   A TN+   E G TPLHL+   + V  A++L + GA     N E +TPL V+
Sbjct: 159 LYYKASTNIQDTE-GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 56/160 (35%), Positives = 80/160 (50%), Gaps = 4/160 (2%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           A +AG    V  +L+ G   N +D  GW+ LH +A+ G++  V+  L  GA     +   
Sbjct: 47  ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ-N 105

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
           G T LHYAA   R  IA ++LE     D   AK +   T +H AA  G    + +LL +K
Sbjct: 106 GCTPLHYAASKNRHEIAVMLLEGGANPD---AKDHYEATAMHRAAAKGNLKMIHILLYYK 162

Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
           A  +    +G TPL LA   ER    K+L+   A+I I+N
Sbjct: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 4/140 (2%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A +AG    V+ +L +G   N  + NG T LH++A++ +     + LE GA+P  KD
Sbjct: 77  LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
                TA+H AA  G  ++  ++L   Y     N +  +G TPLH+A    R    +LL+
Sbjct: 137 HYEA-TAMHRAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLHLACDEERVEEAKLLV 192

Query: 138 EFKAEVDPLSDKGTTPLQLA 157
              A +   + +  TPLQ+A
Sbjct: 193 SQGASIYIENKEEKTPLQVA 212



 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 4/139 (2%)

Query: 116 DGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175
           D  T LH A   G    V  LL+    V+   D G +PL +A    R   VK LL   A 
Sbjct: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98

Query: 176 IDI--QNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARM 232
           ++   QNG   L YA  K+ H    M L+ GA+ +  +     T +H +A + ++    +
Sbjct: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD-AKDHYEATAMHRAAAKGNLKMIHI 157

Query: 233 LYNYGADTNTRNYEGQTPL 251
           L  Y A TN ++ EG TPL
Sbjct: 158 LLYYKASTNIQDTEGNTPL 176



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 5/75 (6%)

Query: 184 LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHL--SALRDDVLCARMLYNYGADTN 241
           L +A    +       LQ G   N  + + G +PLH+  SA RD+++  + L   GA  N
Sbjct: 44  LHWACSAGHTEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIV--KALLGKGAQVN 100

Query: 242 TRNYEGQTPLAVSIS 256
             N  G TPL  + S
Sbjct: 101 AVNQNGCTPLHYAAS 115


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 74/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)

Query: 21  AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
           AV +G + TV  +L +G S N  D      LH++A  G    +++ +  GAD   KD   
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDR-K 205

Query: 81  GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
           G+  LH AA  G+  + + +L      D  NA  N   T LH+A + G+D+    L+   
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN---TALHIACYLGQDAVAIELVNAG 262

Query: 141 AEVDPLSDKGTTPLQLAIIRERSS-CVKILLDHNANIDIQN---GFLLRYAVIKSNHSYC 196
           A V+  +DKG TPL +A +    + C+++L+++ A+++ Q+      L  A I    +  
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322

Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           ++ +Q G++ +    + G TPLH++A     L    L   GADT  R      PL +++ 
Sbjct: 323 QILIQNGSEIDCAD-KFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV- 380

Query: 257 ISGSSRPCLDFL 268
           + G S  C   L
Sbjct: 381 LFGFSDCCRKLL 392



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 64/220 (29%), Positives = 109/220 (49%), Gaps = 8/220 (3%)

Query: 38  YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
           ++P+  DA     L  S  +    C+   L++GADP+++D   G+TA+HYAA +G  +  
Sbjct: 508 HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR-QGYTAVHYAAAYGNRQNL 566

Query: 98  RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
            L+LE  +   + + +S    +PLH+AA+ G    ++ L E    +D    KG T L LA
Sbjct: 567 ELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625

Query: 158 IIRERSSCVKILLDHNANIDI---QNGFLLRYAVIKSNHS-YCRMFLQRGADTNLGRLED 213
             R  + CV++L  H A+  I   +  +   +A   S H+    + +  G   ++  + D
Sbjct: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685

Query: 214 --GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
             GQTPL L+ +   V C  +L   G+  +  +  G+T L
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 68/235 (28%), Positives = 107/235 (45%), Gaps = 32/235 (13%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A+  G V  V  +LE+G + +  D  G T LH  A  G E C+   L+H A    +D
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSN-DGWTPLHVAAHYGRDSFVRLL 136
             G  T +H A+  G   + R +L++   +D ++A  +  G++P+H A++ G +  + LL
Sbjct: 752 FKGR-TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810

Query: 137 LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYC 196
           LE  +    L     TPL  A+I  + S  ++LL          G L             
Sbjct: 811 LEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLL----------GAL------------- 846

Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
                 GA     R   G+TPLH +A  D+V   RML  + A+ N  ++ G+T L
Sbjct: 847 ------GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 70/257 (27%), Positives = 117/257 (45%), Gaps = 29/257 (11%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD---PT 74
           +  A A+G +  V+ +L  G   +  +A G T LH +   G++      +  GA+   P 
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269

Query: 75  VKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVR 134
            K    GFT LH AA+     +   +L +      +N +S +G +PLH+AA +GR +  +
Sbjct: 270 DK----GFTPLHVAAVSTNGALCLELLVNNGAD--VNYQSKEGKSPLHMAAIHGRFTRSQ 323

Query: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKS 191
           +L++  +E+D     G TPL +A        +  L+ + A+     I + F L  AV+  
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383

Query: 192 NHSYCRMFLQRG----------------ADTNLGRLED-GQTPLHLSALRDDVLCARMLY 234
               CR  L  G                A  ++   ++ G+T LH +A   +V C  +L 
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443

Query: 235 NYGADTNTRNYEGQTPL 251
           + GAD   R+  G+TPL
Sbjct: 444 SSGADLRRRDKFGRTPL 460



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 66/243 (27%), Positives = 109/243 (44%), Gaps = 13/243 (5%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPN----GRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
           I  A A G    +R +L+   S +    G D +G++ +H+++  G E C+ + LEH    
Sbjct: 758 IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817

Query: 74  TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
            ++     FT LH A ++ +     ++L +   + I+N++   G TPLH AA     S +
Sbjct: 818 YLEG--NPFTPLHCAVINNQDSTTEMLLGA-LGAKIVNSRDAKGRTPLHAAAFADNVSGL 874

Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN----ANIDIQNGFLLRYAVI 189
           R+LL+ +AEV+     G T L  A    +++ V+ LL         +D      L  A  
Sbjct: 875 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACS 934

Query: 190 KSNHSYCRMFLQRGADTNLGRLEDG--QTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
           K +     M L    D  L    +   Q PLH++A        + L ++GA     + EG
Sbjct: 935 KGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEG 994

Query: 248 QTP 250
            TP
Sbjct: 995 HTP 997



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 61/225 (27%), Positives = 94/225 (41%), Gaps = 6/225 (2%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A   G    ++ + E   + + RD  G T L  +  RG   CV V   HGA   +K+
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
               +T LH AA  G      L+++S  R+DI +     G TPL +A   G    V LLL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKSNHS 194
           E  +  D    +G T L    +     C+  LLDH+A +   D +    +  A    + +
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 195 YCRMFLQRGADT---NLGRLEDGQTPLHLSALRDDVLCARMLYNY 236
             R  LQ    T   + G    G +P+H ++      C  +L  +
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score = 78.2 bits (191), Expect = 7e-15
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 9/220 (4%)

Query: 39  SPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIAR 98
           S N  D +G + LH +   G    V + L  GA   V D       LH+AA  G   + +
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKER-QPLHWAAFLGHLEVLK 190

Query: 99  LMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAI 158
           L++    R   +  K   G+  LH AA  G+   V+ LL   AE+D  +  G T L +A 
Sbjct: 191 LLVA---RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247

Query: 159 IRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHSYC-RMFLQRGADTNLGRLEDG 214
              + +    L++  AN++  N  GF  L  A + +N + C  + +  GAD N  + ++G
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY-QSKEG 306

Query: 215 QTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           ++PLH++A+      +++L   G++ +  +  G TPL V+
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 76/278 (27%), Positives = 123/278 (44%), Gaps = 29/278 (10%)

Query: 13  QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
           +E   +  A   G +  ++ ++ +G     +D  G+ LLH +AA G+   V+  L  GA+
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231

Query: 73  PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
               +  G  TALH A   G+  +A   +E       +N  ++ G+TPLHVAA     + 
Sbjct: 232 IDEPNAFGN-TALHIACYLGQDAVA---IELVNAGANVNQPNDKGFTPLHVAAVSTNGAL 287

Query: 133 -VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAV 188
            + LL+   A+V+  S +G +PL +A I  R +  +IL+ + + ID  + F    L  A 
Sbjct: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347

Query: 189 IKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGA---------- 238
              +       +  GADT    + D   PLHL+ L     C R L + G           
Sbjct: 348 RYGHELLISTLMTNGADTARRGIHD-MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSN 406

Query: 239 --------DTNTRNYEGQTPLAVSISISGSSRPCLDFL 268
                   D NT +  G+T   +  + SG +  CL+ L
Sbjct: 407 EHVLSAGFDINTPDNLGRT--CLHAAASGGNVECLNLL 442



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 9/238 (3%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           +  A A+ +   +  +L      N RD    T LH +AA    +C        +   V D
Sbjct: 78  LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G +ALH+A   G      L+L      ++ + K      PLH AA  G    ++LL+
Sbjct: 138 R-SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ---PLHWAAFLGHLEVLKLLV 193

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHS 194
              A++     KG   L  A    +   VK LL   A ID  N F    L  A      +
Sbjct: 194 ARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA 253

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSAL-RDDVLCARMLYNYGADTNTRNYEGQTPL 251
                +  GA+ N    + G TPLH++A+  +  LC  +L N GAD N ++ EG++PL
Sbjct: 254 VAIELVNAGANVNQPN-DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 70/271 (25%), Positives = 108/271 (39%), Gaps = 34/271 (12%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           + AA + G+V  +  +L  G     RD  G T LH++AA G  +C    +  GA     D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSD-------------------------IINA 112
              G + LHYAA     R A     S + ++                           + 
Sbjct: 487 -CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSL 545

Query: 113 KSNDGWTPLHVAAHYGRDSFVRLLLE--FKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           +   G+T +H AA YG    + LLLE  F    D  S    +PL LA        +K L 
Sbjct: 546 RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLA 605

Query: 171 DHNANIDIQN--GFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
           +   N+D+++  G    +   +   + C  +    GA   +   +   TPLH +A     
Sbjct: 606 ETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665

Query: 228 LCARMLYNYG--AD-TNTRNYEGQTPLAVSI 255
               +L + G  AD T+  +  GQTPL ++I
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAI 696



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 51/155 (32%), Positives = 75/155 (48%), Gaps = 3/155 (1%)

Query: 18   IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG-ADPTVK 76
            + AA  A +V  +R +L+     N  D  G T L  +A  G+   V   L  G AD TV 
Sbjct: 862  LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921

Query: 77   DLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
            D     TALH A   G  + A ++L       +INA ++    PLH+AA  G  S V+ L
Sbjct: 922  DENKN-TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980

Query: 137  LEFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILL 170
            L   A V  + ++G TP L  A  ++ + C+ ++L
Sbjct: 981  LSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015



 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 67/260 (25%), Positives = 105/260 (40%), Gaps = 31/260 (11%)

Query: 33  MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHG 92
           +++ G   +  D  G T LH +A  G E  +   + +GAD T +  I     LH A + G
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFG 383

Query: 93  RARIARLMLESEYRSDIINAKSND---------------GWTPLHVAAHYGRDSFVRLLL 137
            +   R +L S     I+++ SN+               G T LH AA  G    + LLL
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKSNHS 194
              A++      G TPL  A       C   L+   A +   D +    L YA     + 
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY- 502

Query: 195 YCRMFLQRGADTNLGRLEDGQ--TPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
                  R A+ +     D +   PL  S  ++   C   L + GAD + R+ +G T  A
Sbjct: 503 -------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT--A 553

Query: 253 VSISISGSSRPCLDFLQEVT 272
           V  + +  +R  L+ L E++
Sbjct: 554 VHYAAAYGNRQNLELLLEMS 573



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 39/174 (22%), Positives = 66/174 (37%), Gaps = 37/174 (21%)

Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
           IN    +  TPLH AA+ G    ++LLL   A V+       TPL  A        + +L
Sbjct: 34  INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93

Query: 170 LDHNANIDIQNGF------------------------------------LLRYAVIKSNH 193
           L H+A+++ ++                                       L +AV   + 
Sbjct: 94  LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHL 153

Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
               + L +GA  N+   ++ Q PLH +A    +   ++L   GAD   ++ +G
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQ-PLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206


>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
          Length = 389

 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 52/285 (18%)

Query: 18  IQAAVAAGDVHTVRK------MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
           I  AV AGDV  + +      +L  G         GWT  H +A RG++ CV+  + +GA
Sbjct: 30  IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89

Query: 72  DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
           + T +D   G T LH AA HG +   ++ML S     + + +    W P+H AA +GR  
Sbjct: 90  NLTAQD-DRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE---WRPVHYAAFHGRLG 145

Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--------------DHNANI- 176
            ++LL+++   ++ +   G  P+ LA +     C K L+              D+  N+ 
Sbjct: 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205

Query: 177 -----------------------DIQNGFLLRY----AVIKSNHSYCRMFLQRGADTNLG 209
                                  D+++   L +    A  K +    +  ++ G      
Sbjct: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265

Query: 210 RLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
           R ++G TP+H +A +  + C + L   GAD+N  N  G+ P  V+
Sbjct: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 22/165 (13%)

Query: 85  LHYAAMHGRARIARLMLESE---------YRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
           +H+ ++H   R   +   SE         + +DI +  +  GWT  H+AA  G+D+ V+ 
Sbjct: 25  VHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQA 83

Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN---IDIQNGFLLRYAVIKSN 192
           L+   A +    D+G TPL LA     S  ++I+L    +    D +    + YA     
Sbjct: 84  LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143

Query: 193 HSYCRMFLQRGADTNLGRLED----GQTPLHLSALRDDVLCARML 233
               ++ ++ G       +ED    G  P+HL+A+   + C + L
Sbjct: 144 LGCLQLLVKWGCS-----IEDVDYNGNLPVHLAAMEGHLHCFKFL 183


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 83/286 (29%), Positives = 124/286 (43%), Gaps = 32/286 (11%)

Query: 15  ELQIQAAVAAGDVHTVRKMLEQ-------------GYSPNGRDANGWTLLHFSAARGKER 61
           E  +  AV  GDV  V+K++ +               + N +DA+G++ LH +A  G   
Sbjct: 4   EQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLE 63

Query: 62  CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPL 121
            + + LE  A   +KD   G   LHYAA  GR    RL+L +   S  +NA S DG  PL
Sbjct: 64  LIALLLEAQATVDIKD-SNGMRPLHYAAWQGRLEPVRLLLRA---SAAVNAASLDGQIPL 119

Query: 122 HVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNG 181
           H+AA YG      +LL+ ++    ++    TPL LA    R    ++LL+ +  + +  G
Sbjct: 120 HLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEG 179

Query: 182 FL-----------LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCA 230
                        L  A    +    R  L+ G + N  R     T LH +AL       
Sbjct: 180 EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEIN--RQTKTGTALHEAALYGKTEVV 237

Query: 231 RMLYNYGADTNTRNYEGQTPLAV--SISISGSSRPCLDFLQEVTSM 274
           R+L   G D N RN   QT L +    + S +SR     L+E + +
Sbjct: 238 RLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGI 283


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)

Query: 21  AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
           AV  GD   V  +L ++G S    D+ G T  H +AA+G   C+RV + HG D T +D  
Sbjct: 29  AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88

Query: 80  GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
            G +ALH AA +      R +L+S+  ++ ++   + G T LH AA  G    V++L E 
Sbjct: 89  -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 144

Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
           K+ ++     G  PL LA+    S     LLDH A+++ +N       +L   +  SN  
Sbjct: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 202

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
                +++GAD NL     G   LH S L ++     +L    +  AD  T     Q   
Sbjct: 203 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 261

Query: 252 AVSISISGSSRP 263
              IS   S  P
Sbjct: 262 VSKISSERSGTP 273



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
           +L   + +  AV  G       +L+ G   N R+ +G T L  +   G    V   ++ G
Sbjct: 152 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 211

Query: 71  ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
           AD  + D + G+ ALHY+ +   A I  L+L
Sbjct: 212 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 241


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)

Query: 21  AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
           AV  GD   V  +L ++G S    D+ G T  H +AA+G   C+RV + HG D T +D  
Sbjct: 18  AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77

Query: 80  GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
            G +ALH AA +      R +L+S+  ++ ++   + G T LH AA  G    V++L E 
Sbjct: 78  -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 133

Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
           K+ ++     G  PL LA+    S     LLDH A+++ +N       +L   +  SN  
Sbjct: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 191

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
                +++GAD NL     G   LH S L ++     +L    +  AD  T     Q   
Sbjct: 192 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 250

Query: 252 AVSISISGSSRP 263
              IS   S  P
Sbjct: 251 VSKISSERSGTP 262



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
           +L   + +  AV  G       +L+ G   N R+ +G T L  +   G    V   ++ G
Sbjct: 141 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 200

Query: 71  ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
           AD  + D + G+ ALHY+ +   A I  L+L
Sbjct: 201 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 230


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)

Query: 21  AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
           AV  GD   V  +L ++G S    D+ G T  H +AA+G   C+RV + HG D T +D  
Sbjct: 26  AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85

Query: 80  GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
            G +ALH AA +      R +L+S+  ++ ++   + G T LH AA  G    V++L E 
Sbjct: 86  -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141

Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
           K+ ++     G  PL LA+    S     LLDH A+++ +N       +L   +  SN  
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
                +++GAD NL     G   LH S L ++     +L    +  AD  T     Q   
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258

Query: 252 AVSISISGSSRP 263
              IS   S  P
Sbjct: 259 VSKISSERSGTP 270



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
           +L   + +  AV  G       +L+ G   N R+ +G T L  +   G    V   ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208

Query: 71  ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
           AD  + D + G+ ALHY+ +   A I  L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)

Query: 21  AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
           AV  GD   V  +L ++G S    D+ G T  H +AA+G   C+RV + HG D T +D  
Sbjct: 26  AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85

Query: 80  GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
            G +ALH AA +      R +L+S+  ++ ++   + G T LH AA  G    V++L E 
Sbjct: 86  -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141

Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
           K+ ++     G  PL LA+    S     LLDH A+++ +N       +L   +  SN  
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
                +++GAD NL     G   LH S L ++     +L    +  AD  T     Q   
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258

Query: 252 AVSISISGSSRP 263
              IS   S  P
Sbjct: 259 VSKISSERSGTP 270



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
           +L   + +  AV  G       +L+ G   N R+ +G T L  +   G    V   ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208

Query: 71  ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
           AD  + D + G+ ALHY+ +   A I  L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)

Query: 21  AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
           AV  GD   V  +L ++G S    D+ G T  H +AA+G   C+RV + HG D T +D  
Sbjct: 26  AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85

Query: 80  GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
            G +ALH AA +      R +L+S+  ++ ++   + G T LH AA  G    V++L E 
Sbjct: 86  -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141

Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
           K+ ++     G  PL LA+    S     LLDH A+++ +N       +L   +  SN  
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199

Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
                +++GAD NL     G   LH S L ++     +L    +  AD  T     Q   
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258

Query: 252 AVSISISGSSRP 263
              IS   S  P
Sbjct: 259 VSKISSERSGTP 270



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
           +L   + +  AV  G       +L+ G   N R+ +G T L  +   G    V   ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208

Query: 71  ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
           AD  + D + G+ ALHY+ +   A I  L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/231 (33%), Positives = 115/231 (49%), Gaps = 14/231 (6%)

Query: 27  VHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDL--IGGFTA 84
           VH + +  + G  P+  D+ G T LH++A       V+VFL+H   P+VKD   + G T+
Sbjct: 271 VHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTS 325

Query: 85  LHYAAMHGRARIARLMLESEYRSDI-INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV 143
             +AA  G   + R ML    +SDI IN     G T LH AA  G  S V+LLLE  A+V
Sbjct: 326 FMWAAGKGSDDVLRTMLS--LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 144 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGF-LLRYAVIKSNHSYCRMFL 200
           D       TPL  A        ++ L+   A +D+  Q+G  LL +A +  N   C++ +
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443

Query: 201 QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +   + N+     G+TPL  +A    + C  +L    AD N ++ EG+T L
Sbjct: 444 ENKINPNVQDYA-GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 61.6 bits (148), Expect = 7e-10
 Identities = 49/192 (25%), Positives = 89/192 (46%), Gaps = 9/192 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           + AA  +G V TV+ +LE     +  D    T L  +   G +  ++  ++ GA   + D
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G + LH+AA+ G A + ++++E++      N +   G TPL  AA+ G  + + +L+
Sbjct: 421 Q-DGHSLLHWAALGGNADVCQILIENKINP---NVQDYAGRTPLQCAAYGGYINCMAVLM 476

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA-----NIDIQNGFLLRYAVIKSN 192
           E  A+ +    +G T L  +        +K+LLD  A       + +    L YA++   
Sbjct: 477 ENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 193 HSYCRMFLQRGA 204
           H   +  L+ GA
Sbjct: 537 HEVIQFMLEHGA 548



 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 64/272 (23%), Positives = 110/272 (40%), Gaps = 41/272 (15%)

Query: 3   HHHCRRNPELQEELQIQAAVAAGDVHTVRKML--EQGYSPNGRDANGWTLLHFSAARGKE 60
           H   + + +L+       A   G    +R ML  +     N  D  G T LH +A  G  
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370

Query: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
             V++ LE+ A     D++   T L  A   G   + + +++   R D+++    DG + 
Sbjct: 371 STVKLLLENNAQVDATDVMK-HTPLFRACEMGHKDVIQTLIKGGARVDLVD---QDGHSL 426

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
           LH AA  G     ++L+E K   +     G TPLQ A      +C+ +L+++NA+ +IQ+
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486

Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
                                          ++G+T LH S     +   ++L ++ A  
Sbjct: 487 -------------------------------KEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 241 N--TRNYEGQTPLAVSISISGSSRPCLDFLQE 270
           N    N E  TPL    ++ G     + F+ E
Sbjct: 516 NQMENNEERYTPL--DYALLGERHEVIQFMLE 545



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 17/218 (7%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           +H +A  G +  ++  +   +    K+   G T L Y  +  R   A  +L++      +
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA---GADV 74

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N   +   T LH+AA  G   F++LLL  +A       +  TPL L        C+ +LL
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134

Query: 171 DHNA--NIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLE-DGQTPLHLSALR 224
              A   +D Q+      L ++   +N  + ++ ++   D+N+G  + +G+ PLH +A  
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH--DSNIGIPDVEGKIPLHWAANH 192

Query: 225 DD------VLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
            D      V C        +  N ++YEG+TPL  +++
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 53/260 (20%), Positives = 100/260 (38%), Gaps = 45/260 (17%)

Query: 33  MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHG 92
           +L+ G   N  D +  T LH +A +G  R +++ L   A+   KDL    T LH    H 
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDL-EEMTPLHLTTRHR 125

Query: 93  RARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV--------- 143
             +   L+L+     + ++ +  +  T LH +A+Y     V+LL++  + +         
Sbjct: 126 SPKCLALLLKFMAPGE-VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184

Query: 144 ---------DPLS---------------------DKGTTPLQLAIIRERSSCVKILLDH- 172
                    DP +                      +G TPL  A+     + V +L  + 
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244

Query: 173 NANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           + NI   +      L +A +  +     + L+R     +     G TPLH +A  +    
Sbjct: 245 SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAET 304

Query: 230 ARMLYNYGADTNTRNYEGQT 249
            ++   + +  +  + EG+T
Sbjct: 305 VKVFLKHPSVKDDSDLEGRT 324


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 77/231 (33%), Positives = 115/231 (49%), Gaps = 14/231 (6%)

Query: 27  VHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDL--IGGFTA 84
           VH + +  + G  P+  D+ G T LH++A       V+VFL+H   P+VKD   + G T+
Sbjct: 271 VHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTS 325

Query: 85  LHYAAMHGRARIARLMLESEYRSDI-INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV 143
             +AA  G   + R ML    +SDI IN     G T LH AA  G  S V+LLLE  A+V
Sbjct: 326 FMWAAGKGSDDVLRTMLS--LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 144 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGF-LLRYAVIKSNHSYCRMFL 200
           D       TPL  A        ++ L+   A +D+  Q+G  LL +A +  N   C++ +
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443

Query: 201 QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           +   + N+     G+TPL  +A    + C  +L    AD N ++ EG+T L
Sbjct: 444 ENKINPNVQDYA-GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 61.6 bits (148), Expect = 7e-10
 Identities = 49/192 (25%), Positives = 89/192 (46%), Gaps = 9/192 (4%)

Query: 18  IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
           + AA  +G V TV+ +LE     +  D    T L  +   G +  ++  ++ GA   + D
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 78  LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
              G + LH+AA+ G A + ++++E++      N +   G TPL  AA+ G  + + +L+
Sbjct: 421 Q-DGHSLLHWAALGGNADVCQILIENKINP---NVQDYAGRTPLQCAAYGGYINCMAVLM 476

Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA-----NIDIQNGFLLRYAVIKSN 192
           E  A+ +    +G T L  +        +K+LLD  A       + +    L YA++   
Sbjct: 477 ENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 193 HSYCRMFLQRGA 204
           H   +  L+ GA
Sbjct: 537 HEVIQFMLEHGA 548



 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 64/272 (23%), Positives = 110/272 (40%), Gaps = 41/272 (15%)

Query: 3   HHHCRRNPELQEELQIQAAVAAGDVHTVRKML--EQGYSPNGRDANGWTLLHFSAARGKE 60
           H   + + +L+       A   G    +R ML  +     N  D  G T LH +A  G  
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370

Query: 61  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
             V++ LE+ A     D++   T L  A   G   + + +++   R D+++    DG + 
Sbjct: 371 STVKLLLENNAQVDATDVMK-HTPLFRACEMGHKDVIQTLIKGGARVDLVD---QDGHSL 426

Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
           LH AA  G     ++L+E K   +     G TPLQ A      +C+ +L+++NA+ +IQ+
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486

Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
                                          ++G+T LH S     +   ++L ++ A  
Sbjct: 487 -------------------------------KEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 241 N--TRNYEGQTPLAVSISISGSSRPCLDFLQE 270
           N    N E  TPL    ++ G     + F+ E
Sbjct: 516 NQMENNEERYTPL--DYALLGERHEVIQFMLE 545



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 17/218 (7%)

Query: 51  LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
           +H +A  G +  ++  +   +    K+   G T L Y  +  R   A  +L++      +
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA---GADV 74

Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
           N   +   T LH+AA  G   F++LLL  +A       +  TPL L        C+ +LL
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134

Query: 171 DHNA--NIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLE-DGQTPLHLSALR 224
              A   +D Q+      L ++   +N  + ++ ++   D+N+G  + +G+ PLH +A  
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH--DSNIGIPDVEGKIPLHWAANH 192

Query: 225 DD------VLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
            D      V C        +  N ++YEG+TPL  +++
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 53/260 (20%), Positives = 100/260 (38%), Gaps = 45/260 (17%)

Query: 33  MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHG 92
           +L+ G   N  D +  T LH +A +G  R +++ L   A+   KDL    T LH    H 
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDL-EEMTPLHLTTRHR 125

Query: 93  RARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV--------- 143
             +   L+L+     + ++ +  +  T LH +A+Y     V+LL++  + +         
Sbjct: 126 SPKCLALLLKFMAPGE-VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184

Query: 144 ---------DPLS---------------------DKGTTPLQLAIIRERSSCVKILLDH- 172
                    DP +                      +G TPL  A+     + V +L  + 
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244

Query: 173 NANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
           + NI   +      L +A +  +     + L+R     +     G TPLH +A  +    
Sbjct: 245 SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAET 304

Query: 230 ARMLYNYGADTNTRNYEGQT 249
            ++   + +  +  + EG+T
Sbjct: 305 VKVFLKHPSVKDDSDLEGRT 324


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 75/257 (29%), Positives = 125/257 (48%), Gaps = 18/257 (7%)

Query: 8   RNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFL 67
           RN   Q  L I  AV  G +  V+ +L+ G  P+ +D+ G T LH + ++ ++  + V L
Sbjct: 526 RNKRRQTPLHI--AVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583

Query: 68  EHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHY 127
           E GAD T+ +   GF ALH+AA+ G     R++L    R  I++ K +DG+T LH+AA  
Sbjct: 584 EAGADVTITNN-NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642

Query: 128 GRDSFVRLLL-EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLL 184
                  LL+ +  A +D  +    T L LA+ R+ +  V++L+   A +DIQ+  G   
Sbjct: 643 NHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702

Query: 185 RYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSAL----------RDDVLCARMLY 234
            +  ++  H       Q     ++G+++    P   + +          +     A  L 
Sbjct: 703 LHEALR--HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 760

Query: 235 NYGADTNTRNYEGQTPL 251
             GAD + RN +GQ+PL
Sbjct: 761 ANGADLSIRNKKGQSPL 777



 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 75/252 (29%), Positives = 126/252 (50%), Gaps = 14/252 (5%)

Query: 11  ELQEELQIQAAVAAGDVHTVRKMLEQ-GYSPNGRDANGWTLLHFSAARGKERCVRVFLEH 69
           +L EEL    A A GDV  V  +L++     NG+ A G T +  ++  G    +++ L+ 
Sbjct: 430 DLNEELV--KAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQ 486

Query: 70  GADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGR 129
             D   +D  G   A+H+AA      +  ++      S  +NA++    TPLH+A + G 
Sbjct: 487 NVDVEAEDKDGD-RAVHHAAFGDEGAVIEVLHRG---SADLNARNKRRQTPLHIAVNKGH 542

Query: 130 DSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGF-LLRY 186
              V+ LL+F         +G TPL  AI ++R   + +LL+  A++ I   NGF  L +
Sbjct: 543 LQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 602

Query: 187 AVIKSNHSYCRMFLQRGADTNL--GRLEDGQTPLHLSALRDDVLCARMLYNYG-ADTNTR 243
           A ++ N S  R+ L +     +   + +DG T LHL+AL + V  A +L + G A+ + +
Sbjct: 603 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 662

Query: 244 NYEGQTPLAVSI 255
           N   QT L +++
Sbjct: 663 NVNQQTALHLAV 674



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 4/110 (3%)

Query: 150 GTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADT 206
           G T +Q A        +K+LL  N +++ ++      + +A      +   +  +  AD 
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523

Query: 207 NLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
           N  R +  QTPLH++  +  +   + L ++G   + ++ EG TPL  +IS
Sbjct: 524 N-ARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572


>gi|140161500 ankyrin repeat and sterile alpha motif domain
           containing 1 [Homo sapiens]
          Length = 1134

 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 72/229 (31%), Positives = 110/229 (48%), Gaps = 8/229 (3%)

Query: 28  HTVRKMLEQGYSPNGR--DANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
           H +  +L     PN    D+ G+T LH +A  G +  V V L + A   V D  G +  L
Sbjct: 59  HPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP-L 117

Query: 86  HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
           H AA  G A+I RL++        +N ++ND  T LH AA YG    V++LLE   +   
Sbjct: 118 HLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM 177

Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQR 202
            ++K  TPL LA +  R   VK+LL+ + N+   + +    L  A    + +  ++ L  
Sbjct: 178 RNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDA 237

Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
           G D+N  + E G + LH +AL       ++L   G D N ++  G T L
Sbjct: 238 GMDSNY-QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,137,317
Number of Sequences: 37866
Number of extensions: 433925
Number of successful extensions: 5350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 831
Number of HSP's gapped (non-prelim): 1859
length of query: 274
length of database: 18,247,518
effective HSP length: 101
effective length of query: 173
effective length of database: 14,423,052
effective search space: 2495187996
effective search space used: 2495187996
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.