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Search of human proteins with 29571106
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
(402 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 832 0.0
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 817 0.0
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 402 e-112
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 392 e-109
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 380 e-106
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 174 1e-43
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 174 1e-43
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 174 1e-43
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 171 1e-42
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 143 3e-34
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 138 1e-32
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 137 1e-32
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 125 7e-29
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 124 2e-28
gi|7705308 growth differentiation factor 2 [Homo sapiens] 123 3e-28
gi|110349792 growth differentiation factor 1 [Homo sapiens] 116 3e-26
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 114 2e-25
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 110 2e-24
gi|222352098 nodal precursor [Homo sapiens] 106 4e-23
gi|4504699 inhibin beta A precursor [Homo sapiens] 103 4e-22
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 93 4e-19
gi|4885259 myostatin [Homo sapiens] 87 2e-17
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 87 3e-17
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 87 3e-17
gi|13899338 activin beta E [Homo sapiens] 86 6e-17
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 86 8e-17
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 83 4e-16
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 80 3e-15
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 79 7e-15
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 75 1e-13
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 832 bits (2148), Expect = 0.0
Identities = 402/402 (100%), Positives = 402/402 (100%)
Query: 1 MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP 60
MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP
Sbjct: 1 MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP 60
Query: 61 RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH 120
RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH
Sbjct: 61 RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH 120
Query: 121 QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF 180
QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF
Sbjct: 121 QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF 180
Query: 181 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA 240
FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
Sbjct: 181 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA 240
Query: 241 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV 300
PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
Sbjct: 241 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV 300
Query: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
Query: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 817 bits (2110), Expect = 0.0
Identities = 395/402 (98%), Positives = 397/402 (98%)
Query: 1 MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP 60
M A PGPLWLLGL LCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP
Sbjct: 1 MAARPGPLWLLGLTLCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP 60
Query: 61 RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH 120
RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAE+RLGRADLVMSFVNMVERDRALGH
Sbjct: 61 RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRALGH 120
Query: 121 QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF 180
QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF
Sbjct: 121 QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF 180
Query: 181 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA 240
FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
Sbjct: 181 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA 240
Query: 241 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV 300
PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDV GSHGRQV
Sbjct: 241 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV 300
Query: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM P+
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPN 360
Query: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 402 bits (1032), Expect = e-112
Identities = 206/418 (49%), Positives = 281/418 (67%), Gaps = 53/418 (12%)
Query: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED-- 91
RRL ERR++QREIL++LGLP RPRP +P + +SAPLFMLDLY+AM +++ +
Sbjct: 41 RRLRNHERREIQREILSILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEES 97
Query: 92 ------------------------GAPAERRLGR----------------------ADLV 105
G P +L R AD+V
Sbjct: 98 EYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMV 157
Query: 106 MSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVS 164
MSFVN+VERD+ HQ H+KEFRFDLTQIP GEAVTAAEFRIYK S + N T+ +S
Sbjct: 158 MSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKIS 217
Query: 165 MFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETED 224
++Q+++E +NR++DLF LD + +A D GWLV D+T S+ W++ +LGL+L ET D
Sbjct: 218 IYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGD 277
Query: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANR 284
G S++ AGL+G++ P+S+QPF+V FF+AS +R+ RA + + KS+ ++R
Sbjct: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSR 337
Query: 285 LPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNA 344
+ + D + S +Q C++HELYVSF+DLGW DW+IAP+GY+A+YC+GECSFPL++ MNA
Sbjct: 338 MSSV-GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNA 396
Query: 345 TNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
TNHAI+Q+LVHLM PD VPK CCAPTKL+A SVLY+D S+NVIL+K+RNMVV++CGCH
Sbjct: 397 TNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 392 bits (1008), Expect = e-109
Identities = 206/395 (52%), Positives = 275/395 (69%), Gaps = 33/395 (8%)
Query: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGA 93
RRL ++ERR++QREIL++LGLP RPRP + SAP+FMLDLY+AMA + E G
Sbjct: 44 RRLRSQERREMQREILSILGLPHRPRPHLQGKHN----SAPMFMLDLYNAMAVE--EGGG 97
Query: 94 PAERR------------------------LGRADLVMSFVNMVERDRALGHQEPHWKEFR 129
P + L AD+VMSFVN+VE D+ H H +EFR
Sbjct: 98 PGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFR 157
Query: 130 FDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLR 188
FDL++IP GEAVTAAEFRIYK N T +S++QV+QE RESDLF LD +TL
Sbjct: 158 FDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLW 217
Query: 189 AGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFV 248
A +EGWLV D+TA S+ W++ +LGL+L VET DG S++P LAGL+G+ P+++QPF+
Sbjct: 218 ASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFM 277
Query: 249 VTFFRASPSPIRTPRAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELY 307
V FF+A+ R+ R+ +R Q + K+ + +A R+ + ++ S RQ C++HELY
Sbjct: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN-SSSDQRQACKKHELY 336
Query: 308 VSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACC 367
VSF+DLGW DW+IAP+GY+AYYCEGEC+FPL+S MNATNHAI+Q+LVH + P+ VPK CC
Sbjct: 337 VSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCC 396
Query: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
APT+L+A SVLY+D S+NVIL+K+RNMVV+ACGCH
Sbjct: 397 APTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 431
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 380 bits (977), Expect = e-106
Identities = 213/468 (45%), Positives = 279/468 (59%), Gaps = 86/468 (18%)
Query: 20 GGGPG-LRPPPGCPQ-------RRLGARERRDVQREILAVLGLPGRPRP----------- 60
GG PG PP PQ RRL +E+R++Q+EIL+VLGLP RPRP
Sbjct: 47 GGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPA 106
Query: 61 --------------RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGA------------- 93
R P RL SAPLFMLDLY+A++ D+DEDGA
Sbjct: 107 LRQQEEQQQQQQLPRGEPPPGRLK-SAPLFMLDLYNALSADNDEDGASEGERQQSWPHEA 165
Query: 94 ---------------PAERR-----------------------LGRADLVMSFVNMVERD 115
P R+ L AD+VMSFVN+VE D
Sbjct: 166 ASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYD 225
Query: 116 RALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSN 174
+ ++ H KEF+F+L+QIP GE VTAAEFRIYK + N+T +S++QV+QE +
Sbjct: 226 KEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQH 285
Query: 175 RESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAG 234
R+SDLF LD + + A +EGWL D+TA S+ W++ ++GL+L V T DG V P AG
Sbjct: 286 RDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAG 345
Query: 235 LLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHG 294
L+G+ P +QPF+V FF+ S +RT R+ RR+Q + + Q D +
Sbjct: 346 LVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNS 405
Query: 295 SHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLV 354
S + CR+HELYVSFQDLGW DW+IAP+GY+A YC+GECSFPL++ MNATNHAI+Q+LV
Sbjct: 406 SELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLV 465
Query: 355 HLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
HLM P+ VPK CCAPTKL+A SVLY+D ++NVIL+K+RNMVV+ACGCH
Sbjct: 466 HLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 174 bits (442), Expect = 1e-43
Identities = 133/434 (30%), Positives = 203/434 (46%), Gaps = 64/434 (14%)
Query: 4 LPGPLWLLGLALCALGGGGPG---LRPPPGCPQ----------RRLGARER--RDVQREI 48
+PG L+ + LC + GG L P G + RR G RD + +
Sbjct: 2 IPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATL 61
Query: 49 LAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA------ERRLGRA 102
L + GL RP+P A P +M DLY +G+++E+ + ER RA
Sbjct: 62 LQMFGLRRRPQPSKS-------AVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRA 114
Query: 103 DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK--VPSIHLLNRT 160
+ V SF + + G E F F+L+ IP E +++AE R+++ V R
Sbjct: 115 NTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERG 174
Query: 161 LH-VSMFQVVQEQSNRESDLFF---LDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGL 216
H +++++V++ + LD + + W DV+ A W ++ + GL
Sbjct: 175 FHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234
Query: 217 RLYV------ETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270
+ V T G V + G +P +VTF T RR
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT-------RR 287
Query: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV---CRRHELYVSFQDLGWLDWVIAPQGYSA 327
R+ K+S + H R+ CRRH LYV F D+GW DW++AP GY A
Sbjct: 288 RRAKRSPKH-------------HSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA 334
Query: 328 YYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVI 387
+YC G+C FPL +N+TNHAI+Q+LV+ + ++PKACC PT+LSA S+LY D + V+
Sbjct: 335 FYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNSSIPKACCVPTELSAISMLYLDEYDKVV 393
Query: 388 LRKHRNMVVKACGC 401
L+ ++ MVV+ CGC
Sbjct: 394 LKNYQEMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 174 bits (442), Expect = 1e-43
Identities = 133/434 (30%), Positives = 203/434 (46%), Gaps = 64/434 (14%)
Query: 4 LPGPLWLLGLALCALGGGGPG---LRPPPGCPQ----------RRLGARER--RDVQREI 48
+PG L+ + LC + GG L P G + RR G RD + +
Sbjct: 2 IPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATL 61
Query: 49 LAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA------ERRLGRA 102
L + GL RP+P A P +M DLY +G+++E+ + ER RA
Sbjct: 62 LQMFGLRRRPQPSKS-------AVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRA 114
Query: 103 DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK--VPSIHLLNRT 160
+ V SF + + G E F F+L+ IP E +++AE R+++ V R
Sbjct: 115 NTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERG 174
Query: 161 LH-VSMFQVVQEQSNRESDLFF---LDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGL 216
H +++++V++ + LD + + W DV+ A W ++ + GL
Sbjct: 175 FHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234
Query: 217 RLYV------ETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270
+ V T G V + G +P +VTF T RR
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT-------RR 287
Query: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV---CRRHELYVSFQDLGWLDWVIAPQGYSA 327
R+ K+S + H R+ CRRH LYV F D+GW DW++AP GY A
Sbjct: 288 RRAKRSPKH-------------HSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA 334
Query: 328 YYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVI 387
+YC G+C FPL +N+TNHAI+Q+LV+ + ++PKACC PT+LSA S+LY D + V+
Sbjct: 335 FYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNSSIPKACCVPTELSAISMLYLDEYDKVV 393
Query: 388 LRKHRNMVVKACGC 401
L+ ++ MVV+ CGC
Sbjct: 394 LKNYQEMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 174 bits (442), Expect = 1e-43
Identities = 133/434 (30%), Positives = 203/434 (46%), Gaps = 64/434 (14%)
Query: 4 LPGPLWLLGLALCALGGGGPG---LRPPPGCPQ----------RRLGARER--RDVQREI 48
+PG L+ + LC + GG L P G + RR G RD + +
Sbjct: 2 IPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATL 61
Query: 49 LAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA------ERRLGRA 102
L + GL RP+P A P +M DLY +G+++E+ + ER RA
Sbjct: 62 LQMFGLRRRPQPSKS-------AVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRA 114
Query: 103 DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK--VPSIHLLNRT 160
+ V SF + + G E F F+L+ IP E +++AE R+++ V R
Sbjct: 115 NTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERG 174
Query: 161 LH-VSMFQVVQEQSNRESDLFF---LDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGL 216
H +++++V++ + LD + + W DV+ A W ++ + GL
Sbjct: 175 FHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGL 234
Query: 217 RLYV------ETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270
+ V T G V + G +P +VTF T RR
Sbjct: 235 AIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALT-------RR 287
Query: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV---CRRHELYVSFQDLGWLDWVIAPQGYSA 327
R+ K+S + H R+ CRRH LYV F D+GW DW++AP GY A
Sbjct: 288 RRAKRSPKH-------------HSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA 334
Query: 328 YYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVI 387
+YC G+C FPL +N+TNHAI+Q+LV+ + ++PKACC PT+LSA S+LY D + V+
Sbjct: 335 FYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNSSIPKACCVPTELSAISMLYLDEYDKVV 393
Query: 388 LRKHRNMVVKACGC 401
L+ ++ MVV+ CGC
Sbjct: 394 LKNYQEMVVEGCGC 407
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 171 bits (433), Expect = 1e-42
Identities = 131/424 (30%), Positives = 203/424 (47%), Gaps = 60/424 (14%)
Query: 6 GPLWLLGLALC-ALGGGGPGLRPP----------PGCPQRRLGARERRDVQREILAVLGL 54
G LL L L L GG GL P G P + + + +L++ GL
Sbjct: 4 GTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGL 63
Query: 55 PGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPA-----ERRLGRADLVMSFV 109
RP P A P +MLDLY +G + G+PA ER RA+ V SF
Sbjct: 64 KQRPTPSRD-------AVVPPYMLDLYRRHSG---QPGSPAPDHRLERAASRANTVRSFH 113
Query: 110 NMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL--NRTLH--VSM 165
+ + + F F+L+ IP E +T+AE ++++ L N + H +++
Sbjct: 114 HEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINI 173
Query: 166 FQVVQEQS--NRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL---YV 220
+++++ + ++ LD + + W DVT A W + H + G + ++
Sbjct: 174 YEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHL 233
Query: 221 ETEDGHSV-DPGLAGLLGQRAPRSQQ--PFVVTFFRASPSPIRTPRAVRPLRRRQPKKSN 277
E + G S ++ L Q Q P +VTF PL +R+ +++
Sbjct: 234 EEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKG--------HPLHKREKRQAK 285
Query: 278 ELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFP 337
Q RL + C+RH LYV F D+GW DW++AP GY A+YC GEC FP
Sbjct: 286 H-KQRKRL------------KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFP 332
Query: 338 LDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVK 397
L +N+TNHAI+Q+LV+ + +PKACC PT+LSA S+LY D + V+L+ +++MVV+
Sbjct: 333 LADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVE 391
Query: 398 ACGC 401
CGC
Sbjct: 392 GCGC 395
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 143 bits (360), Expect = 3e-34
Identities = 68/141 (48%), Positives = 91/141 (64%)
Query: 261 TPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVI 320
+PRAV RRR+ A G HG GR C R L+V F++LGW DW+I
Sbjct: 309 SPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWII 368
Query: 321 APQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYY 380
AP Y AY+CEG C FPL S + TNHAI+Q+L++ M PDA P +CC P +LS S+LY
Sbjct: 369 APLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYI 428
Query: 381 DSSNNVILRKHRNMVVKACGC 401
D++NNV+ +++ +MVV+ACGC
Sbjct: 429 DAANNVVYKQYEDMVVEACGC 449
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 138 bits (347), Expect = 1e-32
Identities = 122/439 (27%), Positives = 198/439 (45%), Gaps = 97/439 (22%)
Query: 25 LRPPPGCPQRRLG--ARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPL------- 75
L P PG P+ + G + R+ R + LPG +APP A +P+S L
Sbjct: 97 LPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG---KAPPKAGSVPSSFLLKKAREPG 153
Query: 76 ------------------FMLDLYHAMAGDDDEDG-APAERRLGRADLVMSFVNMVERDR 116
+ML LY ++ D + G + + G A+ + SF++ + DR
Sbjct: 154 PPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDR 213
Query: 117 ALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTL----HVSMFQVVQEQ 172
++ + + FD++ + + + AE RI + + ++
Sbjct: 214 GPVVRK---QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCP 269
Query: 173 SNRESDLFFLDLQTLRAGD-EGWLVLDVTAASDCWLLKRHKDLGLRLYVETED---GHSV 228
S R+ LD++++ D GW V D+ W L R+ +L +E E G +V
Sbjct: 270 SGRQP-ASLLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSAQLCLELEAWERGRAV 322
Query: 229 DPGLAGLLGQRAPRS--QQPFVVTFFRASPSPI------------------------RTP 262
D L GL RA R ++ + F R + R
Sbjct: 323 D--LRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKR 380
Query: 263 RAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322
RA PL RQ K+ ++ +A C R L+V+F+D+GW DW+IAP
Sbjct: 381 RA--PLATRQGKRPSKNLKAR-----------------CSRKALHVNFKDMGWDDWIIAP 421
Query: 323 QGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDS 382
Y A++CEG C FPL S + TNHA++Q+L++ M P++ P CC PT+LS S+L+ DS
Sbjct: 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDS 481
Query: 383 SNNVILRKHRNMVVKACGC 401
+NNV+ +++ +MVV++CGC
Sbjct: 482 ANNVVYKQYEDMVVESCGC 500
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 137 bits (346), Expect = 1e-32
Identities = 121/401 (30%), Positives = 178/401 (44%), Gaps = 75/401 (18%)
Query: 55 PGRPRPRAPPAASRLPASAPL-FMLDLYHAMA-GDDDEDGAPAERRLGRADLVMSFVNMV 112
P +PRA R P P +ML +Y + + A + A+ + SFV+
Sbjct: 75 PRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRG 134
Query: 113 ERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRT--LHVSMFQVV 169
D L H +++ FD++ + E + AE R+++ PS LHV +F +
Sbjct: 135 LDD--LSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCL 192
Query: 170 QEQSNRESDLFFLDLQTLR---AGDEGWLVLDVTAASDCWLLKRH---KDLGLRL---YV 220
LD +TL A GW V DV W RH K L L L +
Sbjct: 193 SP--------LLLDARTLDPQGAPPAGWEVFDV------WQGLRHQPWKQLCLELRAAWG 238
Query: 221 ETEDGHSV----------DPGLAGL-LGQRA-PRSQQPFVVTFFRAS------------- 255
E + G + P L L G+R P ++ +V F R+
Sbjct: 239 ELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLG 298
Query: 256 ---------------PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV 300
P P P A RP ++ A+R HG R
Sbjct: 299 SAEAAGPGAGAEGSWPPPSGAPDA-RPWLPSPGRRRRRTAFASR----HGKRHGKKSRLR 353
Query: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
C + L+V+F++LGW DW+IAP Y AY+CEG C FPL S + TNHAI+Q+L++ M P
Sbjct: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
Query: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
+ P +CC PTKL+ S+LY D+ NNV+ +++ +MVV++CGC
Sbjct: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 125 bits (314), Expect = 7e-29
Identities = 52/104 (50%), Positives = 79/104 (75%), Gaps = 1/104 (0%)
Query: 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM 357
+ +C RH+L+++F+DLGW W+IAP+G+ A YC GEC F L +N++N+A +Q+L+H +
Sbjct: 261 KNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAV 320
Query: 358 MPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
P+ +P+A C PTKLS S+LY D+++NVILR + +MVV CGC
Sbjct: 321 DPE-IPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 124 bits (310), Expect = 2e-28
Identities = 96/369 (26%), Positives = 156/369 (42%), Gaps = 48/369 (13%)
Query: 64 PAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGHQEP 123
P P +ML+LY+ A D + A+++ SF N + +
Sbjct: 72 PTQDSAKVDPPEYMLELYNKFATD--------RTSMPSANIIRSFKNEDLFSQPVSFNGL 123
Query: 124 HWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLH------VSMFQVVQEQSNRES 177
F+++ IP E V AE R+Y + +R ++ +++F+V++ + + E
Sbjct: 124 RKYPLLFNVS-IPHHEEVIMAELRLYTLVQ---RDRMIYDGVDRKITIFEVLESKGDNEG 179
Query: 178 DLFFLDLQT--LRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGL 235
+ L L + + + W DVT A W L +++E++ + D L
Sbjct: 180 ERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRL 239
Query: 236 -LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRL--------P 286
+ A P ++ F S ++ R + +LP+ + L P
Sbjct: 240 EIDTSAQNKHNPLLIVF-----SDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGP 294
Query: 287 G-----------IFDD---VHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEG 332
G I+D + + C+R LY+ F+++GW W+IAP GY AY C G
Sbjct: 295 GEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRG 354
Query: 333 ECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHR 392
C++PL + T HAI+Q+LVHL KACC PTKL S+LY D K+
Sbjct: 355 VCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYE 414
Query: 393 NMVVKACGC 401
M V CGC
Sbjct: 415 GMAVSECGC 423
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 123 bits (308), Expect = 3e-28
Identities = 124/454 (27%), Positives = 167/454 (36%), Gaps = 85/454 (18%)
Query: 5 PGPLW------------LLGLALCALGGGGPGLR-------PPPGCPQRRLGARE-RRDV 44
PG LW L G L + G G G P G P+ + +V
Sbjct: 3 PGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENV 62
Query: 45 QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADL 104
+ + L L L G P+ + P +M+DLY+ D A +++
Sbjct: 63 KVDFLRSLNLSG------VPSQDKTRVEPPQYMIDLYNRYTSDKSTTPA--------SNI 108
Query: 105 VMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKV------PSIHLLN 158
V SF P K IP E +T AE R+Y PS L
Sbjct: 109 VRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKG 168
Query: 159 RTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL 218
+ + + FL Q ++ DEGW L+V++A W+ +L
Sbjct: 169 SVVIYDVLDGTDAWDSATETKTFLVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKL 226
Query: 219 YVETEDGH--------SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270
V E SV PG L PF V F S + R LR
Sbjct: 227 EVTVESHRKGCDTLDISVPPGSRNL----------PFFVVFSNDHSSGTKETRL--ELRE 274
Query: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV----------------------CRRHELYV 308
+ + + G + SH C++ L V
Sbjct: 275 MISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRV 334
Query: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCA 368
+F+D+GW W+IAP+ Y AY C+G C FPL + T HAI+Q+LVHL P V KACC
Sbjct: 335 NFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCV 394
Query: 369 PTKLSATSVLYYDSSNNVILRKH-RNMVVKACGC 401
PTKLS SVLY D L+ H M V CGC
Sbjct: 395 PTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 116 bits (291), Expect = 3e-26
Identities = 73/203 (35%), Positives = 101/203 (49%), Gaps = 30/203 (14%)
Query: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRAS-------PSPIRTPRAVRPLRRRQPKKSN 277
G DPG LL Q P P A+ P +R A+RP R P
Sbjct: 173 GAGADPGPV-LLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRP---RAPAACA 228
Query: 278 ELPQANRLPGIFDD---------------VHGSHGRQVCRRHELYVSFQDLGWLDWVIAP 322
L +A+ L D V G CR LYVSF+++GW WVIAP
Sbjct: 229 RLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAP 288
Query: 323 QGYSAYYCEGECSFPLDSCMN----ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVL 378
+G+ A YC+G+C+ P+ + A NHA+L++L+H P A CC P +LS SVL
Sbjct: 289 RGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVL 348
Query: 379 YYDSSNNVILRKHRNMVVKACGC 401
++D+S+NV+LR++ +MVV CGC
Sbjct: 349 FFDNSDNVVLRQYEDMVVDECGC 371
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 114 bits (285), Expect = 2e-25
Identities = 52/152 (34%), Positives = 85/152 (55%), Gaps = 8/152 (5%)
Query: 258 PIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV-------CRRHELYVSF 310
P +T +A P + + KK + P FD+ R+ C R L V F
Sbjct: 320 PYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDF 379
Query: 311 QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM-MPDAVPKACCAP 369
D+GW +W+I+P+ + AYYC G C FP+ + +NHA +QS+V + + +P+ CC P
Sbjct: 380 ADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVP 439
Query: 370 TKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
K+S+ S+L++D + NV+L+ + NM V++C C
Sbjct: 440 EKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 110 bits (276), Expect = 2e-24
Identities = 56/154 (36%), Positives = 85/154 (55%), Gaps = 9/154 (5%)
Query: 256 PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQ-------VCRRHELYV 308
PSP R + RP R+ + KK E+ A FD+ R+ VC R L V
Sbjct: 325 PSPFRALKP-RPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKV 383
Query: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM-MPDAVPKACC 367
F D+GW +W+I+P+ + AYYC G C FP+ + +NHA +QS+V + + +P+ CC
Sbjct: 384 DFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCC 443
Query: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
P K+++ VL+ D + NV+L+ + NM V C C
Sbjct: 444 VPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 106 bits (264), Expect = 4e-23
Identities = 90/317 (28%), Positives = 143/317 (45%), Gaps = 36/317 (11%)
Query: 99 LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLN 158
L RAD++ S + D A+ Q +W F FD + + E + AE R+ + L
Sbjct: 52 LPRADIIRS---LQAEDVAVDGQ--NWT-FAFDFSFLSQQEDLAWAELRLQLSSPVDLPT 105
Query: 159 R-TLHVSMFQVVQEQSNRESDL----FFLDLQTLRAGDE----GWLVLDVTAASDCWLLK 209
+L + +F + + + SD F +DL T+ G +VL+VT WL
Sbjct: 106 EGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL-- 163
Query: 210 RHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPI-RTPRAVRPL 268
+H +++ ++ + G+ PR P S + + R +
Sbjct: 164 KHPG-------------ALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGS 210
Query: 269 RRRQPKKSNELPQANRLPGIFDDVHGSHG----RQVCRRHELYVSFQDLGWLDWVIAPQG 324
+S+ Q +L + H H Q+CR+ + V F +GW W+I P+
Sbjct: 211 TLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQ 270
Query: 325 YSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSN 384
Y+AY CEGEC P+ + TNHA +QSL+ P VP CCAP K S+LY D +
Sbjct: 271 YNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD-NG 329
Query: 385 NVILRKHRNMVVKACGC 401
V+L H++M+V+ CGC
Sbjct: 330 RVLLDHHKDMIVEECGC 346
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 103 bits (256), Expect = 4e-22
Identities = 108/437 (24%), Positives = 170/437 (38%), Gaps = 58/437 (13%)
Query: 8 LWLLGLALCALG--------GGGPGLRPPPGCPQRRLGARER----------RDVQREIL 49
LWL G L + G G P CP L A + V++ IL
Sbjct: 4 LWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHIL 63
Query: 50 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDG-APAERRLGRADLVMSF 108
+L L RP P +P +A L + H G E+G E +GR +
Sbjct: 64 NMLHLKKRPDVTQP-----VPKAALLNAIRKLHV--GKVGENGYVEIEDDIGRRAEMNEL 116
Query: 109 VNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVT--AAEFRIYKVPSIHLLNRTLHVSMF 166
+ K F++++ + +V A + KVP NRT
Sbjct: 117 MEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKA---NRTRTKVTI 173
Query: 167 QVVQEQSNRESDL-----------------FFLDLQTLRAGDEGWLVLDVTAASDCWLLK 209
++ Q+Q + + L L + + A W V V+++ L +
Sbjct: 174 RLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQ 233
Query: 210 RHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLR 269
L +R+ E L G ++ + + + ++ RP
Sbjct: 234 GKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFL 293
Query: 270 RRQPKKSNELPQANRLPGIFDDVHGSHGR-QVCRRHELYVSFQDLGWLDWVIAPQGYSAY 328
Q ++S + P R G+ D G+ +C + + +VSF+D+GW DW+IAP GY A
Sbjct: 294 MLQARQSEDHPHRRRRRGLECD-----GKVNICCKKQFFVSFKDIGWNDWIIAPSGYHAN 348
Query: 329 YCEGECSFPLDSCMNATNHAILQSLVHLMM----PDAVPKACCAPTKLSATSVLYYDSSN 384
YCEGEC + ++ + H M P A K+CC PTKL S+LYYD
Sbjct: 349 YCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQ 408
Query: 385 NVILRKHRNMVVKACGC 401
N+I + +NM+V+ CGC
Sbjct: 409 NIIKKDIQNMIVEECGC 425
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 93.2 bits (230), Expect = 4e-19
Identities = 88/356 (24%), Positives = 143/356 (40%), Gaps = 31/356 (8%)
Query: 60 PRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALG 119
P P RL + +ML+LY A D G P E R A +V + R
Sbjct: 53 PGEQPRKPRLLGHSLRYMLELYRRSA---DSHGHPRENRTIGATMVRLVKPLTSVAR--- 106
Query: 120 HQEPHWKEFRFDLTQIPAGEAVTAAEF-RIYKVPSIHL----LNRTLHVSMFQVVQEQSN 174
PH + + P + R V HL N + HV + VQ+
Sbjct: 107 ---PHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPW--VQKNPT 161
Query: 175 RESDLFFLDLQTLRAGDEGWLVLDVT--AASDCWLLKRHKDLGLRLYVETEDGHSVDPGL 232
D W +D+T W K H+ L LR + + D G
Sbjct: 162 NHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQK----DSG- 216
Query: 233 AGL-LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDD 291
GL L F++ +F + IR + + ++ + L + + GI +
Sbjct: 217 -GLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAE 275
Query: 292 V------HGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNAT 345
V H C H +SF+ LGW W+IAP Y+ YC+G C L +N+
Sbjct: 276 VTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSP 335
Query: 346 NHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
NHAI+Q+L++ ++ +VP+ C P K SVL +++ +++ +++ M+ ++C C
Sbjct: 336 NHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 87.4 bits (215), Expect = 2e-17
Identities = 64/213 (30%), Positives = 89/213 (41%), Gaps = 46/213 (21%)
Query: 194 WLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSV-----DPGLAGLLGQRAPRSQQPFV 248
W +DV WL + +LG+ + E+GH + PG GL PF+
Sbjct: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGL---------NPFL 253
Query: 249 VTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYV 308
+ + +P R+ R G+ D H + R C R+ L V
Sbjct: 254 EV--KVTDTPKRSRRDF---------------------GLDCDEHSTESR--CCRYPLTV 288
Query: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCA 368
F+ GW DW+IAP+ Y A YC GEC F T+ LVH P CC
Sbjct: 289 DFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCT 341
Query: 369 PTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
PTK+S ++LY++ +I K MVV CGC
Sbjct: 342 PTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 87.0 bits (214), Expect = 3e-17
Identities = 75/298 (25%), Positives = 130/298 (43%), Gaps = 28/298 (9%)
Query: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 153 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 212
Query: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 213 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 272
Query: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 273 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 328
Query: 287 G-IFDDVHGSHGRQV-CRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
D + Q C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 329 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 384
Query: 344 ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
T H+ + SL + + P+A CC L ++LYY I + NM+VK+C C
Sbjct: 385 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 441
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 87.0 bits (214), Expect = 3e-17
Identities = 75/298 (25%), Positives = 130/298 (43%), Gaps = 28/298 (9%)
Query: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 125 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 184
Query: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 185 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 244
Query: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 245 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 300
Query: 287 G-IFDDVHGSHGRQV-CRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
D + Q C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 301 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 356
Query: 344 ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
T H+ + SL + + P+A CC L ++LYY I + NM+VK+C C
Sbjct: 357 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 413
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 85.9 bits (211), Expect = 6e-17
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 2/104 (1%)
Query: 300 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSC--MNATNHAILQSLVHLM 357
+C R + YV FQ+LGW DW++ P+GY YC G+C L + A+ H+ + SL+
Sbjct: 246 LCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKAN 305
Query: 358 MPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
P +CC PT S+LY D + NV+ +MVV+ACGC
Sbjct: 306 NPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 85.5 bits (210), Expect = 8e-17
Identities = 41/106 (38%), Positives = 59/106 (55%), Gaps = 5/106 (4%)
Query: 300 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPL----DSCMNATNHAILQSLVH 355
+C R + ++ F+ +GW DW+IAP GY YCEG C L S + + Q +
Sbjct: 302 LCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361
Query: 356 LMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
+ P V +CC PTKLS S+LY+D N++ R NM+V+ CGC
Sbjct: 362 GLNPGTV-NSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 83.2 bits (204), Expect = 4e-16
Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 30/294 (10%)
Query: 126 KEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDL 184
K FRF+++ + + AEFR+ +VP+ + +FQ+++ + +
Sbjct: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGK 189
Query: 185 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQ 244
G WL DVT WLL+R +LGL + + H+ P G
Sbjct: 190 NLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPC-HTFQPN-----GDILENIH 243
Query: 245 QPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV---- 300
+ + F + L++++ + L P D+ G G++
Sbjct: 244 EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNP-GQGGQRKKRAL 302
Query: 301 ------------CRRHELYVSF-QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNH 347
C LY+ F QDLGW WV P+GY A +C G C + + T H
Sbjct: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSA---DTTH 358
Query: 348 AILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
+ + L + + P+A CC P L ++LYY + + NMVVK+C C
Sbjct: 359 STVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 80.1 bits (196), Expect = 3e-15
Identities = 37/109 (33%), Positives = 61/109 (55%), Gaps = 4/109 (3%)
Query: 297 GRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSC--MNATNHAILQSLV 354
G ++C R E +V F+++GW DW+I P+GY+ +C G+C + + A+ H + +L+
Sbjct: 243 GSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLL 302
Query: 355 HLMMPDAVP--KACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
+CC PT S+LYYD +N++ +MVV+ACGC
Sbjct: 303 KANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 79.0 bits (193), Expect = 7e-15
Identities = 45/121 (37%), Positives = 60/121 (49%), Gaps = 9/121 (7%)
Query: 281 QANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDS 340
++ R G+ D H S R C R+ L V F+ GW DW+IAP+ Y A YC G+C +
Sbjct: 295 RSRRNLGLDCDEHSSESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF-- 349
Query: 341 CMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACG 400
M H LV P CC PTK+S ++LY++ +I K MVV CG
Sbjct: 350 -MQKYPHT---HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCG 405
Query: 401 C 401
C
Sbjct: 406 C 406
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 74.7 bits (182), Expect = 1e-13
Identities = 28/101 (27%), Positives = 55/101 (54%)
Query: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
C H+ +SF L W +W++AP Y+ YC+G+C + + H ++Q++++ +
Sbjct: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
Query: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
+VP+ C P K S SVL + ++ +++ +M+ C C
Sbjct: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,020,219
Number of Sequences: 37866
Number of extensions: 979992
Number of successful extensions: 4553
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 4176
Number of HSP's gapped (non-prelim): 394
length of query: 402
length of database: 18,247,518
effective HSP length: 105
effective length of query: 297
effective length of database: 14,271,588
effective search space: 4238661636
effective search space used: 4238661636
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.