Search of human proteins with 29570791

Search of human proteins with 29570791

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo
sapiens]
         (391 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo sapi...   806   0.0  
gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo sap...   806   0.0  
gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]    602   e-172
gi|29570793 casein kinase II alpha 1 subunit isoform b [Homo sap...   531   e-151
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   148   9e-36
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         142   7e-34
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             137   1e-32
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        137   2e-32
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   137   2e-32
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        137   2e-32
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        136   4e-32
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           135   5e-32
gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]             135   6e-32
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   134   1e-31
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]             134   2e-31
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         133   2e-31
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         133   2e-31
gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo sap...   132   4e-31
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   132   5e-31
gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo sapi...   131   9e-31
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        130   2e-30
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    130   2e-30
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   130   3e-30
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   129   3e-30
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]           129   3e-30
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   129   3e-30
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   129   6e-30
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        128   1e-29
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]             127   2e-29
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        127   2e-29

>gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo
           sapiens]
          Length = 391

 Score =  806 bits (2083), Expect = 0.0
 Identities = 391/391 (100%), Positives = 391/391 (100%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
Sbjct: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120
           NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
Sbjct: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120

Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
           FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360
           LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360

Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391
           PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
Sbjct: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391


>gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo
           sapiens]
          Length = 391

 Score =  806 bits (2083), Expect = 0.0
 Identities = 391/391 (100%), Positives = 391/391 (100%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
Sbjct: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120
           NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
Sbjct: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120

Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
           FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360
           LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360

Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391
           PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
Sbjct: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391


>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
          Length = 350

 Score =  602 bits (1553), Expect = e-172
 Identities = 285/334 (85%), Positives = 309/334 (92%), Gaps = 1/334 (0%)

Query: 1   MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59
           M GP   SRARVY +VN+ R REYWDYE+HV  WGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 1   MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60

Query: 60  TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT
Sbjct: 61  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120

Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
           DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA
Sbjct: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
           EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY
Sbjct: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD
Sbjct: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300

Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333
            LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q++
Sbjct: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ 334


>gi|29570793 casein kinase II alpha 1 subunit isoform b [Homo
           sapiens]
          Length = 255

 Score =  531 bits (1367), Expect = e-151
 Identities = 255/255 (100%), Positives = 255/255 (100%)

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196
           MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY
Sbjct: 1   MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 60

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
           FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD
Sbjct: 61  FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 120

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
           YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR
Sbjct: 121 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 180

Query: 317 EAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 376
           EAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA
Sbjct: 181 EAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 240

Query: 377 NPLGMPVPAAAGAQQ 391
           NPLGMPVPAAAGAQQ
Sbjct: 241 NPLGMPVPAAAGAQQ 255


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  148 bits (373), Expect = 9e-36
 Identities = 102/301 (33%), Positives = 166/301 (55%), Gaps = 29/301 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRG 90
           D +Q V K+G G Y  V++A N    + V +K ++       V    I REI +L+ L+ 
Sbjct: 2   DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAI-REISLLKELKH 60

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDY 146
            PNI+ L D+V +   R   LVFE ++    K +  T    L  + I+ Y++++L+ + +
Sbjct: 61  -PNIVRLLDVVHN--ERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSF 117

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVD 205
           CHS  ++HRD+KP N++I+ E   ++L D+GLA  F  P + Y   V + +++ PE+L+ 
Sbjct: 118 CHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLG 176

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDKYNI 263
            + Y  ++D+WS+GC+ A M+ RK   F G    DQL RI ++LGT  ED +  + +   
Sbjct: 177 SKFYTTAVDIWSIGCIFAEMVTRK-ALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQL-- 233

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
              P +     + +RK  E  V +     + PE  D L +LL+YD   R+TA+ A+ HPY
Sbjct: 234 ---PDYKGSFPKWTRKGLEEIVPN-----LEPEGRDLLMQLLQYDPSQRITAKTALAHPY 285

Query: 324 F 324
           F
Sbjct: 286 F 286


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  142 bits (357), Expect = 7e-34
 Identities = 94/315 (29%), Positives = 165/315 (52%), Gaps = 20/315 (6%)

Query: 19  RPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PV 73
           R + ++  + +   W     Y     +G G Y  V  AI+  + EKV +K L       +
Sbjct: 5   RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLY-QTLT 129
             K+  RE+ +L++++   N+I L D+     S      F  V     TD +++     +
Sbjct: 65  FAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
           +  I++ +Y++LK L Y HS G++HRD+KP N+ ++ E  +L+++D+GLA   H   E  
Sbjct: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAEMT 180

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
             V +R+++ PE+++ +  Y+ ++D+WS+GC++A M+  K   F G D  DQL +I KV 
Sbjct: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK-TLFKGKDYLDQLTQILKVT 239

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           G     +++ K N +    +   L +  RK + +          SP+A D L+K+L  D 
Sbjct: 240 GVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDV 293

Query: 310 QSRLTAREAMEHPYF 324
             RLTA +A+ HP+F
Sbjct: 294 DKRLTAAQALTHPFF 308


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  137 bits (346), Expect = 1e-32
 Identities = 91/301 (30%), Positives = 161/301 (53%), Gaps = 28/301 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           +DY  + K+G G Y  V++  + T  + V +K ++   +++       REI +L+ LR  
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD------IRFYMYEILKALD 145
           PNI++L D++    SR   L+FE ++  D K+   ++          ++ Y+Y+IL+ + 
Sbjct: 61  PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204
           +CHS  ++HRD+KP N++ID +   ++L D+GLA  F  P + Y   V + +++ PE+L+
Sbjct: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               Y   +D+WS+G + A +   K+P FHG    DQL RI + LGT          N E
Sbjct: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTP---------NNE 226

Query: 265 LDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           + P    +   +++  +W+    + +   +    LD L K+L YD   R++ + A+ HPY
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286

Query: 324 F 324
           F
Sbjct: 287 F 287


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  137 bits (345), Expect = 2e-32
 Identities = 97/323 (30%), Positives = 166/323 (51%), Gaps = 43/323 (13%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKK 77
           ++  E +   W      Q +R +G G Y  V  A +    +KV VK L       +  ++
Sbjct: 8   FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------------ 125
             RE+++L++L+   N+I L D+       TPA   E     DF ++Y            
Sbjct: 68  TYRELRLLKHLKH-ENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNN 115

Query: 126 ----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
               Q L+D  ++F +Y++L+ L Y HS GI+HRD+KP NV + +E  +LR++D+GLA  
Sbjct: 116 IVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV-NEDCELRILDFGLAR- 173

Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
               +E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++ + +  F G D  DQ
Sbjct: 174 -QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQ 231

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
           L RI +V+GT    + + K + E    +   L    +K         N     P A+D L
Sbjct: 232 LKRIMEVVGTPS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLL 285

Query: 302 DKLLRYDHQSRLTAREAMEHPYF 324
            ++L  D   R++A EA+ H YF
Sbjct: 286 GRMLVLDSDQRVSAAEALAHAYF 308


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  137 bits (344), Expect = 2e-32
 Identities = 93/318 (29%), Positives = 165/318 (51%), Gaps = 33/318 (10%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKK 77
           ++  E +   W   + YQ +  +G G Y  V  A +     +V VK L       +  K+
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE---------HVNNTDFKQLY--Q 126
             RE+++L++++   N+I L D+       TPA   E         H+   D   +   Q
Sbjct: 68  TYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
            LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ + +E  +L+++D+GLA   H   
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV-NEDCELKILDFGLAR--HTDD 177

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
           E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  +   F G D+ DQL  I 
Sbjct: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGTDHIDQLKLIL 236

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
           +++GT    + + K + E    +   L +  +  +       N     P A+D L+K+L 
Sbjct: 237 RLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLV 290

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R+TA +A+ H YF
Sbjct: 291 LDSDKRITAAQALAHAYF 308


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  137 bits (344), Expect = 2e-32
 Identities = 100/334 (29%), Positives = 174/334 (52%), Gaps = 33/334 (9%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MS P P+R+  Y    T               W  +  Y+ ++ +G G Y  V  A++  
Sbjct: 1   MSSPPPARSGFYRQEVTK------------TAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48

Query: 61  NNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115
              KV +K L +P +     K+  RE+++L+++R   N+I L D+     +      F  
Sbjct: 49  TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYL 107

Query: 116 VN---NTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK 170
           V     TD  +L  ++ L +  I+F +Y++LK L Y H+ GI+HRD+KP N+ + +E  +
Sbjct: 108 VMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV-NEDCE 166

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
           L+++D+GLA       E    V +R+++ PE+++++  Y  ++D+WS+GC++A MI  K 
Sbjct: 167 LKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK- 223

Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290
             F G D+ DQL  I KV GT    +++ +   +    +   L    +K +   + +   
Sbjct: 224 TLFKGSDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTN--- 279

Query: 291 HLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
              SP A++ L+K+L  D + R+TA EA+ HPYF
Sbjct: 280 --ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  136 bits (342), Expect = 4e-32
 Identities = 95/305 (31%), Positives = 160/305 (52%), Gaps = 27/305 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           +++Q V K+G G Y  V++A N    E V +K ++   + +       REI +L+ L   
Sbjct: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYD---IRFYMYEILKALDY 146
           PNI+ L D++         LVFE ++  D K+      LT      I+ Y++++L+ L +
Sbjct: 61  PNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVD 205
           CHS  ++HRD+KP N++I+ E   ++L D+GLA  F  P + Y   V + +++ PE+L+ 
Sbjct: 118 CHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-E 264
            + Y  ++D+WSLGC+ A M+ R+   F G    DQL RI + LGT D   +    ++ +
Sbjct: 177 CKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
             P F          +W R   S+    +  +    L ++L YD   R++A+ A+ HP+F
Sbjct: 236 YKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286

Query: 325 YTVVK 329
             V K
Sbjct: 287 QDVTK 291


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  135 bits (341), Expect = 5e-32
 Identities = 90/301 (29%), Positives = 160/301 (53%), Gaps = 28/301 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           +DY  + K+G G Y  V++  + T  + V +K ++   +++       REI +L+ LR  
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD------IRFYMYEILKALD 145
           PNI++L D++    SR   L+FE ++  D K+   ++          ++ Y+Y+IL+ + 
Sbjct: 61  PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204
           +CHS  ++HRD+KP N++ID +   ++L D+GLA  F  P + Y     + +++ PE+L+
Sbjct: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLL 176

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               Y   +D+WS+G + A +   K+P FHG    DQL RI + LGT          N E
Sbjct: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTP---------NNE 226

Query: 265 LDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           + P    +   +++  +W+    + +   +    LD L K+L YD   R++ + A+ HPY
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286

Query: 324 F 324
           F
Sbjct: 287 F 287


>gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]
          Length = 419

 Score =  135 bits (340), Expect = 6e-32
 Identities = 92/318 (28%), Positives = 158/318 (49%), Gaps = 31/318 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPN 93
           +Y+ + K+G G +SEV +  ++ +      K +K     +++    REI+ L  L   PN
Sbjct: 3   NYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPN 62

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSM 150
           I+ L ++V D  S + AL+ E ++   ++ +      L++  I  YMY++ K+LD+ H  
Sbjct: 63  ILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRN 122

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           GI HRDVKP N++I  +   L+L D+G     +  Q Y   +++R+++ PE L+    Y 
Sbjct: 123 GIFHRDVKPENILIKQD--VLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYT 180

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
           Y +D+WS GC+    I   +P F G +  DQ+ +I  V+GT      + K+         
Sbjct: 181 YKMDLWSAGCVFYE-IASLQPLFPGVNELDQISKIHDVIGTP-AQKILTKF--------- 229

Query: 271 DILGRHSRKRWERFVHSENQHL------VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               + SR     F   +   +      +SP+ L  L  ++ YD   R+ A +A++HPYF
Sbjct: 230 ----KQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYF 285

Query: 325 YTVVKDQAR-MGSSSMPG 341
               K + R +GS    G
Sbjct: 286 QEQRKTEKRALGSHRKAG 303


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  134 bits (337), Expect = 1e-31
 Identities = 92/318 (28%), Positives = 164/318 (51%), Gaps = 33/318 (10%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKK 77
           ++  E +   W   + YQ +  +G G Y  V  A +     +V VK L       +  K+
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE---------HVNNTDFKQLY--Q 126
             RE+++L++++   N+I L D+       TPA   E         H+   D   +   Q
Sbjct: 68  TYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
            LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ + +E  +L+++D+GLA   H   
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV-NEDCELKILDFGLAR--HTDD 177

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
           E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  +   F G D+ +QL +I 
Sbjct: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGTDHINQLQQIM 236

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
           ++ GT   Y  I++        +   L +  +  +       N     P A+D L+K+L 
Sbjct: 237 RLTGTPPAY-LINRMPSHEARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLV 290

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R+TA +A+ H YF
Sbjct: 291 LDSDKRITAAQALAHAYF 308


>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
          Length = 315

 Score =  134 bits (336), Expect = 2e-31
 Identities = 91/303 (30%), Positives = 153/303 (50%), Gaps = 33/303 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91
           + Y+ + K G G Y  VF+  N T+ + V VK        PV KK   REI++L+ L+  
Sbjct: 2   EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH- 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
           PN++ L ++ +    R   LVFE+ ++T   +L +    + D  I+  +++ L+AL++CH
Sbjct: 61  PNLVNLIEVFRR--KRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCH 118

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
               +HRD+KP N++I  +   +++ D+G A+   PG  Y   VA+R+++ PELLV    
Sbjct: 119 IHNCIHRDIKPENILITKQGI-IKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQ 177

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           Y  S+D+W++GC+ A ++   +P + G  + DQL  I + LG             +L PR
Sbjct: 178 YGSSVDIWAIGCVFAELL-TGQPLWPGKSDVDQLYLIIRTLG-------------KLIPR 223

Query: 269 FNDILGRHSRKRWERFVHSENQHL-------VSPEALDFLDKLLRYDHQSRLTAREAMEH 321
              I   +           E+          V P AL+F+   L+ +   RLT  + +E 
Sbjct: 224 HQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLES 283

Query: 322 PYF 324
            YF
Sbjct: 284 SYF 286


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  133 bits (335), Expect = 2e-31
 Identities = 89/297 (29%), Positives = 156/297 (52%), Gaps = 21/297 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
           Y  +  +G G Y  V  A +  N  +V +K + P + +    +  REIKIL   R   NI
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENI 83

Query: 95  ITLADIVKDPV--SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           I + DI++ P         + + +  TD  +L +T  L++  I +++Y+IL+ L Y HS 
Sbjct: 84  IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206
            ++HRD+KP N+++ +    L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 144 NVLHRDLKPSNLLL-NTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 202

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++  
Sbjct: 203 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKA- 260

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
             +   L   ++  W R   + +      +ALD LDK+L ++   R+   +A+ HPY
Sbjct: 261 RNYLLSLPHKNKVPWNRLFPNADS-----KALDLLDKMLTFNPHKRIEVEQALAHPY 312


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  133 bits (335), Expect = 2e-31
 Identities = 89/297 (29%), Positives = 156/297 (52%), Gaps = 21/297 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
           Y  +  +G G Y  V  A +  N  +V +K + P + +    +  REIKIL   R   NI
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENI 83

Query: 95  ITLADIVKDPV--SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           I + DI++ P         + + +  TD  +L +T  L++  I +++Y+IL+ L Y HS 
Sbjct: 84  IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206
            ++HRD+KP N+++ +    L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 144 NVLHRDLKPSNLLL-NTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 202

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++  
Sbjct: 203 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKA- 260

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
             +   L   ++  W R   + +      +ALD LDK+L ++   R+   +A+ HPY
Sbjct: 261 RNYLLSLPHKNKVPWNRLFPNADS-----KALDLLDKMLTFNPHKRIEVEQALAHPY 312


>gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
           sapiens]
          Length = 420

 Score =  132 bits (333), Expect = 4e-31
 Identities = 105/364 (28%), Positives = 168/364 (46%), Gaps = 49/364 (13%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L    NI+ L
Sbjct: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL-DHCNIVRL 112

Query: 98  A---------------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142
                           ++V D V  T   V  H     + +  QTL    ++ YMY++ +
Sbjct: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH-----YSRAKQTLPVIYVKLYMYQLFR 167

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           +L Y HS GI HRD+KP N+++D +   L+L D+G A+    G+     + SRY++ PEL
Sbjct: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +     Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT        +  
Sbjct: 228 IFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP-----TREQI 281

Query: 263 IELDPRFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            E++P + +    +     W +           PEA+    +LL Y   +RLT  EA  H
Sbjct: 282 REMNPNYTEFKFPQIKAHPWTKVFRPR----TPPEAIALCSRLLEYTPTARLTPLEACAH 337

Query: 322 PYFYTVVKDQARMGSSSMPGG---------STPVSSANMMSGISSVPTPSPLGPLAGSPV 372
            +F     D+ R  +  +P G         +T   S+N       +P  + +   A +P 
Sbjct: 338 SFF-----DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPT 392

Query: 373 IAAA 376
            A A
Sbjct: 393 NATA 396


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  132 bits (332), Expect = 5e-31
 Identities = 97/304 (31%), Positives = 162/304 (53%), Gaps = 38/304 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLRG 90
           Y+ +  LG G+++ V++A +   N+ V +K +K   + + K        REIK+L+ L  
Sbjct: 12  YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70

Query: 91  GPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
            PNII L D    K  +S    LVF+ +  TD + + +     LT   I+ YM   L+ L
Sbjct: 71  HPNIIGLLDAFGHKSNIS----LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203
           +Y H   I+HRD+KP+N+++D E+  L+L D+GLA+ F  P + Y  +V +R+++ PELL
Sbjct: 126 EYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              +MY   +DMW++GC+LA ++ R  PF  G  + DQL RI + LGT            
Sbjct: 185 FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGT------------ 231

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVS---PEALDFLDKLLRYDHQSRLTAREAME 320
             + ++ D+        ++ F      H+ S    + LD +  L  ++  +R+TA +A++
Sbjct: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291

Query: 321 HPYF 324
             YF
Sbjct: 292 MKYF 295


>gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
           sapiens]
          Length = 433

 Score =  131 bits (330), Expect = 9e-31
 Identities = 109/372 (29%), Positives = 168/372 (45%), Gaps = 52/372 (13%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L    NI+ L
Sbjct: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL-DHCNIVRL 112

Query: 98  A---------------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142
                           ++V D V  T   V  H     + +  QTL    ++ YMY++ +
Sbjct: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH-----YSRAKQTLPVIYVKLYMYQLFR 167

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           +L Y HS GI HRD+KP N+++D +   L+L D+G A+    G+     + SRY++ PEL
Sbjct: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT---EDLYDYID 259
           +     Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT   E + +   
Sbjct: 228 IFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286

Query: 260 KY------NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
            Y       I+  P   D  G        R           PEA+    +LL Y   +RL
Sbjct: 287 NYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPR----TPPEAIALCSRLLEYTPTARL 342

Query: 314 TAREAMEHPYFYTVVKDQARMGSSSMPGG---------STPVSSANMMSGISSVPTPSPL 364
           T  EA  H +F     D+ R  +  +P G         +T   S+N       +P  + +
Sbjct: 343 TPLEACAHSFF-----DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 397

Query: 365 GPLAGSPVIAAA 376
              A +P  A A
Sbjct: 398 QAAASTPTNATA 409


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  130 bits (328), Expect = 2e-30
 Identities = 97/302 (32%), Positives = 152/302 (50%), Gaps = 28/302 (9%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93
           Y L R+LG+G Y  V++A++    E V +K +    + K       REI +L+     PN
Sbjct: 13  YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSM 150
           II+L D+++    R   LVFE ++ TD   + +    L D  +R   Y++L+A  + HS 
Sbjct: 73  IISLLDVIRAENDRDIYLVFEFMD-TDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSG 131

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP------GQEYNVRVASRYFKGPELLV 204
            ++HRD KP NV++D  +  ++L D+GLA            Q     VA+R+++ PE+L+
Sbjct: 132 HVVHRDQKPSNVLLD-ANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLL 190

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL---GTEDLYDYIDKY 261
               Y   +DMWSLGC+L  M+ R  P F G     QL  I + +     EDL       
Sbjct: 191 SSHRYTLGVDMWSLGCILGEML-RGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGC 249

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
              +  +    LG   R+  +  +  +     SPEALD L +LL +    RL+A +A++H
Sbjct: 250 RASVLHQ----LGSRPRQTLDALLPPD----TSPEALDLLRRLLVFAPDKRLSATQALQH 301

Query: 322 PY 323
           PY
Sbjct: 302 PY 303


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  130 bits (328), Expect = 2e-30
 Identities = 92/304 (30%), Positives = 156/304 (51%), Gaps = 23/304 (7%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILEN 87
           ++G  D Y+ + KLG G Y+ V++  +  N + V +K+++  +++       RE  +L+ 
Sbjct: 110 KFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKG 169

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKA 143
           L+   NI+ L DI+      T  LVFE+V+ TD  Q        L   +++ +++++L+ 
Sbjct: 170 LKHA-NIVLLHDIIH--TKETLTLVFEYVH-TDLCQYMDKHPGGLHPDNVKLFLFQLLRG 225

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPEL 202
           L Y H   I+HRD+KP N++I  +  +L+L D+GLA     P   Y+  V + +++ P++
Sbjct: 226 LSYIHQRYILHRDLKPQNLLIS-DTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDV 284

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDK 260
           L+    Y   LDMW +GC+   MI     F    D  DQL RI  VLGT  ED +  +  
Sbjct: 285 LLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHS 344

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                  RF     ++ R+ W +  +  +       A D   KLL+   ++RL+A+ A+ 
Sbjct: 345 LPHFKPERFTLYSSKNLRQAWNKLSYVNH-------AEDLASKLLQCSPKNRLSAQAALS 397

Query: 321 HPYF 324
           H YF
Sbjct: 398 HEYF 401


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  130 bits (326), Expect = 3e-30
 Identities = 88/311 (28%), Positives = 158/311 (50%), Gaps = 21/311 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
           Y  ++ +G G Y  V  A +     +V +K + P + +    +  REI+IL   R   N+
Sbjct: 42  YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 100

Query: 95  ITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150
           I + DI++     +     + + +  TD  +L   Q L++  I +++Y+IL+ L Y HS 
Sbjct: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206
            ++HRD+KP N++I +    L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 161 NVLHRDLKPSNLLI-NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++  
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA- 277

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
             +   L   ++  W +     +      +ALD LD++L ++   R+T  EA+ HPY   
Sbjct: 278 RNYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332

Query: 327 VVKDQARMGSS 337
                  +G S
Sbjct: 333 YYDPTDEVGQS 343


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  129 bits (325), Expect = 3e-30
 Identities = 86/297 (28%), Positives = 155/297 (52%), Gaps = 21/297 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
           Y  ++ +G G Y  V  A +     +V +K + P + +    +  REI+IL   R   N+
Sbjct: 42  YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 100

Query: 95  ITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150
           I + DI++     +     + + +  TD  +L   Q L++  I +++Y+IL+ L Y HS 
Sbjct: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206
            ++HRD+KP N++I +    L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 161 NVLHRDLKPSNLLI-NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++  
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA- 277

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
             +   L   ++  W +     +      +ALD LD++L ++   R+T  EA+ HPY
Sbjct: 278 RNYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPY 329


>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
          Length = 483

 Score =  129 bits (325), Expect = 3e-30
 Identities = 97/332 (29%), Positives = 156/332 (46%), Gaps = 30/332 (9%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y  ++ +G G +  V++A      E V +K  K ++ K+ K RE++I+  L    NI+ L
Sbjct: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIK--KVLQDKRFKNRELQIMRKL-DHCNIVRL 175

Query: 98  ADIVKDPVSRTPAL----VFEHVNNT------DFKQLYQTLTDYDIRFYMYEILKALDYC 147
                    +   L    V E+V  T       F +   T+    ++ YMY++ ++L Y 
Sbjct: 176 RYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYI 235

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS G+ HRD+KP N+++D +   L+L D+G A+    G+     + SRY++ PEL+    
Sbjct: 236 HSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 295

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT        +   E++P
Sbjct: 296 DYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP-----TREQIREMNP 349

Query: 268 RFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            + +    +     W +   S       PEA+     LL Y   SRL+  EA  H +F  
Sbjct: 350 NYTEFKFPQIKAHPWTKVFKSR----TPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-- 403

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSV 358
              D+ R   + +P         N  +G  S+
Sbjct: 404 ---DELRCLGTQLPNNRPLPPLFNFSAGELSI 432


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  129 bits (325), Expect = 3e-30
 Identities = 91/300 (30%), Positives = 158/300 (52%), Gaps = 31/300 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGGPN 93
           Y+ + K+G G Y  VF+A N   +E V +K ++             REI +L+ L+   N
Sbjct: 4   YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYD---IRFYMYEILKALDYCHS 149
           I+ L D++      T  LVFE  +  D K+ + +   D D   ++ +++++LK L +CHS
Sbjct: 63  IVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQM 208
             ++HRD+KP N++I+  + +L+L D+GLA  F  P + Y+  V + +++ P++L   ++
Sbjct: 120 RNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           Y  S+DMWS GC+ A +     P F G+D  DQL RI ++LGT              + +
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT------------PTEEQ 226

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +  +      K +  +  + +   V P+      D L  LL+ +   R++A EA++HPYF
Sbjct: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  129 bits (323), Expect = 6e-30
 Identities = 94/310 (30%), Positives = 158/310 (50%), Gaps = 37/310 (11%)

Query: 33  WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENL 88
           +G    Y  + KLG G Y+ V++ I+  N + V +K++    ++ +     RE  +L+ L
Sbjct: 46  FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144
           +   NI+ L DI+      T   VFE+++ TD  Q        L  +++R +M+++L+ L
Sbjct: 106 KHA-NIVLLHDIIH--TKETLTFVFEYMH-TDLAQYMSQHPGGLHPHNVRLFMFQLLRGL 161

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203
            Y H   ++HRD+KP N++I H   +L+L D+GLA     P Q Y+  V + +++ P+ L
Sbjct: 162 AYIHHQHVLHRDLKPQNLLISH-LGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDAL 220

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDN-YDQLVRIAKVLG--TEDLYDYIDK 260
           +    Y   LD+W  GC+   M F+ +P F G  N  +QL +I +VLG  TED +  + K
Sbjct: 221 LGATEYSSELDIWGAGCIFIEM-FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSK 279

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLV------SPEALDFLDKLLRYDHQSRLT 314
                 P +N          W       + H+V       PEA D   ++L+   + R++
Sbjct: 280 L-----PNYN--------PEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS 326

Query: 315 AREAMEHPYF 324
           A+EA+ H YF
Sbjct: 327 AQEALVHDYF 336


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  128 bits (321), Expect = 1e-29
 Identities = 86/300 (28%), Positives = 154/300 (51%), Gaps = 21/300 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPVKKKKIKREIKILENLRGG 91
           D Y ++ ++G G +  VF+A ++   E     KV ++ L+     +  REIK L+ +   
Sbjct: 2   DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDN 61

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCH 148
             ++ L  +   P      L FE + +      +   + L    ++ Y+  +LK + +CH
Sbjct: 62  QYVVQLKAVF--PHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLVDY 206
           +  I+HRD+KP N++I    + L++ D+GLA  + P   + Y  +VA+R+++ PELL   
Sbjct: 120 ANNIVHRDLKPANLLISASGQ-LKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGA 178

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD  +D+WS+GC++  ++    P F G ++ +QL  + ++LGT +   + +   +   
Sbjct: 179 RQYDQGVDLWSVGCIMGELL-NGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTEL--- 234

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
           P +N I    S K        E    VSP+ALD L + L Y    R+ A +A+ H YF+T
Sbjct: 235 PDYNKI----SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 290


>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
          Length = 358

 Score =  127 bits (319), Expect = 2e-29
 Identities = 92/315 (29%), Positives = 155/315 (49%), Gaps = 36/315 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91
           + Y+ + K+G G Y  VF+  N    + V +K        PV KK   REI++L+ L+  
Sbjct: 3   EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH- 61

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--YQT-LTDYDIRFYMYEILKALDYCH 148
           PN++ L ++ +    R   LVFE+ ++T   +L  YQ  + ++ ++   ++ L+A+++CH
Sbjct: 62  PNLVNLLEVFRR--KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQ 207
               +HRDVKP N++I  +H  ++L D+G A     P   Y   VA+R+++ PELLV   
Sbjct: 120 KHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDT 178

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y   +D+W++GC+ A ++    P + G  + DQL  I K LG             +L P
Sbjct: 179 QYGPPVDVWAIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLG-------------DLIP 224

Query: 268 RFNDILGRHSRKRWERFVHSENQH-------LVSPEALDFLDKLLRYDHQSRLTAREAME 320
           R   +   +      +    E+          +S  AL  L   L  D   RLT  + + 
Sbjct: 225 RHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLH 284

Query: 321 HPYFYTV--VKDQAR 333
           HPYF  +  ++D A+
Sbjct: 285 HPYFENIREIEDLAK 299


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  127 bits (318), Expect = 2e-29
 Identities = 94/347 (27%), Positives = 178/347 (51%), Gaps = 48/347 (13%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILE 86
           + +G  + Y  + KLG G Y+ V++  +   +  V +K ++   ++       RE+ +L+
Sbjct: 163 IGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLK 222

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-------YDIRFYMYE 139
           +L+   NI+TL DI+    S T  LVFE+++    K L Q L D       ++++ ++++
Sbjct: 223 DLKHA-NIVTLHDIIHTEKSLT--LVFEYLD----KDLKQYLDDCGNIINMHNVKLFLFQ 275

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFK 198
           +L+ L YCH   ++HRD+KP N++I +E  +L+L D+GLA     P + Y+  V + +++
Sbjct: 276 LLRGLAYCHRQKVLHRDLKPQNLLI-NERGELKLADFGLARAKSIPTKTYSNEVVTLWYR 334

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            P++L+    Y   +DMW +GC+   M   + P F G    +QL  I ++LGT     + 
Sbjct: 335 PPDILLGSTDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWP 393

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
              + E    +N     + + R E  +   +   +  +  D L KLL+++ ++R++A +A
Sbjct: 394 GILSNEEFKTYN-----YPKYRAEALL--SHAPRLDSDGADLLTKLLQFEGRNRISAEDA 446

Query: 319 MEHPYFYTV--------------------VKDQARMGSSSMPGGSTP 345
           M+HP+F ++                    ++ +A + SSSMP    P
Sbjct: 447 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRP 493


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,910,859
Number of Sequences: 37866
Number of extensions: 751162
Number of successful extensions: 5120
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 567
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 3192
Number of HSP's gapped (non-prelim): 1160
length of query: 391
length of database: 18,247,518
effective HSP length: 104
effective length of query: 287
effective length of database: 14,309,454
effective search space: 4106813298
effective search space used: 4106813298
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.