Search of human proteins with 122937307

Search of human proteins with 122937307

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937307 acyl-CoA synthetase medium-chain family member 4
[Homo sapiens]
         (580 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H...  1201   0.0  
gi|42544132 SA hypertension-associated homolog isoform 1 [Homo s...   753   0.0  
gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Ho...   746   0.0  
gi|157311624 acyl-CoA synthetase medium-chain family member 2B [...   686   0.0  
gi|157311622 acyl-CoA synthetase medium-chain family member 2B [...   686   0.0  
gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H...   683   0.0  
gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H...   642   0.0  
gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   637   0.0  
gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   637   0.0  
gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s...   484   e-137
gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Ho...   451   e-127
gi|253970489 acyl-CoA synthetase short-chain family member 2 iso...   187   2e-47
gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom...   187   2e-47
gi|8923896 acyl-CoA synthetase short-chain family member 2 isofo...   183   4e-46
gi|13375727 acyl-CoA synthetase short-chain family member 3 [Hom...   161   2e-39
gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]       133   4e-31
gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]       133   4e-31
gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]       124   2e-28
gi|38524616 solute carrier family 27, member 1 [Homo sapiens]          89   1e-17
gi|40807357 solute carrier family 27 (fatty acid transporter), m...    77   6e-14
gi|227499619 solute carrier family 27 (fatty acid transporter), ...    75   1e-13
gi|13236579 solute carrier family 27 member 3 [Homo sapiens]           67   3e-11
gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]                  65   1e-10
gi|62865631 solute carrier family 27 (fatty acid transporter), m...    64   3e-10
gi|13325055 solute carrier family 27 (fatty acid transporter), m...    64   3e-10
gi|57165412 acyl-CoA synthetase long-chain family member 6 isofo...    58   3e-08
gi|57165410 acyl-CoA synthetase long-chain family member 6 isofo...    58   3e-08
gi|40807491 acyl-CoA synthetase long-chain family member 1 [Homo...    58   3e-08
gi|13325057 solute carrier family 27 (fatty acid transporter), m...    57   5e-08
gi|42794760 acyl-CoA synthetase long-chain family member 5 isofo...    55   2e-07

>gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo
           sapiens]
          Length = 580

 Score = 1201 bits (3106), Expect = 0.0
 Identities = 580/580 (100%), Positives = 580/580 (100%)

Query: 1   MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLD 60
           MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLD
Sbjct: 1   MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLD 60

Query: 61  QWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVI 120
           QWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVI
Sbjct: 61  QWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVI 120

Query: 121 LPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVL 180
           LPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVL
Sbjct: 121 LPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVL 180

Query: 181 ECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQ 240
           ECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQ
Sbjct: 181 ECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQ 240

Query: 241 HSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQF 300
           HSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQF
Sbjct: 241 HSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQF 300

Query: 301 DTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRV 360
           DTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRV
Sbjct: 301 DTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRV 360

Query: 361 QTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIA 420
           QTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIA
Sbjct: 361 QTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIA 420

Query: 421 LRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGY 480
           LRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGY
Sbjct: 421 LRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGY 480

Query: 481 RIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHV 540
           RIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHV
Sbjct: 481 RIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHV 540

Query: 541 KKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR 580
           KKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR
Sbjct: 541 KKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR 580


>gi|42544132 SA hypertension-associated homolog isoform 1 [Homo
           sapiens]
          Length = 586

 Score =  753 bits (1944), Expect = 0.0
 Identities = 343/559 (61%), Positives = 446/559 (79%), Gaps = 1/559 (0%)

Query: 21  RRLHKDHQLWTPLTLADFEAINRCNR-PLPKNFNFAADVLDQWSQKEKTGERPANPALWW 79
           R LHKD++  TP   +++E++ +  +  +P+ FNFA DVLDQW+ KEK G++P+NPA WW
Sbjct: 26  RALHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWW 85

Query: 80  VNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGI 139
           +N  G+E++WSF ELGSLSRK AN+L++ C LQRGDR+ +ILPR+PEWWL NVAC+RTG 
Sbjct: 86  INRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGT 145

Query: 140 IFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGW 199
           + +PGT QLT KDILYRL++SKA CI+ ++ +APAV+++  +C +L +KL+VS  S  GW
Sbjct: 146 VLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGW 205

Query: 200 LSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLD 259
            + +EL + AS+ H+CV+T   E M I+FTSGT+G+PKM  H+ SS G+G ++ GR+WLD
Sbjct: 206 GNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLD 265

Query: 260 LKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCS 319
           L  SD++WN SDTGW K+A  SVFS W+ GACVF H + +F+  + L TL+ YPIT  CS
Sbjct: 266 LTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCS 325

Query: 320 PPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMIC 379
            PTVYRMLVQ D+  YKFKSL+HC++ GEP+ P+V E+WR +TGL++YEGYGQTE  +IC
Sbjct: 326 APTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLIC 385

Query: 380 ANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNP 439
            N KG +IKPGSMGK    +DV+I+D NGNVLPPG+EG+I +++ P RPF  F+ YVDNP
Sbjct: 386 GNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNP 445

Query: 440 QKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVE 499
            KTA+T+RG+FY+TGDRG MD DGYFWFV RADDVI+SSGYRIGPFEVE+AL EHP+V E
Sbjct: 446 SKTASTLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAE 505

Query: 500 SAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQEL 559
           SAVVSSPD IRGEVVKAFVVL   +KS++ E+L  E+Q+HVKK+TAPYKYPRKVEF+QEL
Sbjct: 506 SAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQEL 565

Query: 560 PKTITGKIKRNVLRDQEWR 578
           PKTI+GK KRN LR +EW+
Sbjct: 566 PKTISGKTKRNELRKKEWK 584


>gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Homo
           sapiens]
          Length = 579

 Score =  746 bits (1925), Expect = 0.0
 Identities = 349/543 (64%), Positives = 435/543 (80%), Gaps = 1/543 (0%)

Query: 35  LADFEAINRCNRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFREL 94
           +A +EAI+   + +P+ FNFA DVLD WS+ E+ G RP NPA WWVNG G E+KWSF EL
Sbjct: 36  VATWEAISLGRQLVPEYFNFAHDVLDVWSRLEEAGHRPPNPAFWWVNGTGAEIKWSFEEL 95

Query: 95  GSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDIL 154
           G  SRKAANVL   CGLQ GDR+ ++LPR+PEWWLV+VAC+RTG + +PG  QLT KD+ 
Sbjct: 96  GKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLK 155

Query: 155 YRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHS 214
           YRL+AS+AK I+ S+ +AP V++I  ECP L+TKLLVS  S  GWL+F+EL + AS EH+
Sbjct: 156 YRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSSRPGWLNFRELLREASTEHN 215

Query: 215 CVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGW 274
           C+ T S++P+ IYFTSGTTG PKM +HSQSS G+GF   GR W+ L  SDI WN +DTGW
Sbjct: 216 CMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDTGW 275

Query: 275 VKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKR 334
           VKAA  ++FS+W  G+C+FVH + + D    L+TL+ +PITTLC  PT++R+LVQ+DL R
Sbjct: 276 VKAA-WTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFPITTLCCVPTIFRLLVQEDLTR 334

Query: 335 YKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGK 394
           Y+F+SLRHCLTGGE LNP+V E+W+ QTG+ELYEGYGQ+E  +ICAN KG +IK GSMGK
Sbjct: 335 YQFQSLRHCLTGGEALNPDVREKWKHQTGVELYEGYGQSETVVICANPKGMKIKSGSMGK 394

Query: 395 GMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTG 454
              PYDVQI+D+ GNVLPPG+EG +A+R++PTRPFCFF+ Y+DNP+KTAA+ +GDFY+TG
Sbjct: 395 ASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNCYLDNPEKTAASEQGDFYITG 454

Query: 455 DRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVV 514
           DR  MD DGYFWF+GR DDVI SS YRIGP EVESAL EHPAV+ESAVVSSPD IRGEVV
Sbjct: 455 DRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVV 514

Query: 515 KAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRD 574
           KAF+VL   + S++PE LT ELQ+HVK+ TAPYKYPRKV FV ELPKT++GKI+R+ LR 
Sbjct: 515 KAFIVLTPAYSSHDPEALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRS 574

Query: 575 QEW 577
           QEW
Sbjct: 575 QEW 577


>gi|157311624 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  686 bits (1769), Expect = 0.0
 Identities = 325/534 (60%), Positives = 408/534 (76%), Gaps = 1/534 (0%)

Query: 45  NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANV 104
           ++ +P  FNFA+DVLD W+  EK G+R  +PALWWVNGKG E+ W+FREL   S++AAN+
Sbjct: 37  HQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANI 96

Query: 105 LTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKC 164
           L+  CGLQRGDR+AV+LPR+PEWWLV + CIR G+IFMPGTIQ+ + DILYRL+ SKAK 
Sbjct: 97  LSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKA 156

Query: 165 IVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPM 224
           IVA +EV   V+++  ECP L+ KLLVS +S +GWL+F++L   AS  H CVETGSQE  
Sbjct: 157 IVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS 216

Query: 225 TIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFS 284
            IYFTSGT+G PKMA+HS SSLG+   +    W  L++SDI+W +SDTGW+   +GS+  
Sbjct: 217 AIYFTSGTSGLPKMAEHSYSSLGLKAKMDAG-WTGLQASDIMWTISDTGWILNILGSLLE 275

Query: 285 SWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCL 344
           SW  GAC FVH + +FD    L TL++YPI ++   P VYRML+Q+DL  YKF  L++CL
Sbjct: 276 SWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCL 335

Query: 345 TGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQII 404
            GGE L PE LE WR QTGL++ E YGQTE G+ C   K  +IKPG MG     YDVQ+I
Sbjct: 336 AGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI 395

Query: 405 DENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGY 464
           D+ GNVLPPG EG+I +R+KP RP   FS YV+NP KTAA IRGDF++ GDRG+ D DGY
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGY 455

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           F F+GRADD+I SSGYRIGP EVE+AL++HPAVVE+AV+SSPD +RGEVVKAFV+LA+ F
Sbjct: 456 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 515

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWR 578
            S++PE+LT ELQ HVK  TAPYKYPRK+EFV  LPKT+TGKI+R  LRD+EW+
Sbjct: 516 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWK 569


>gi|157311622 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  686 bits (1769), Expect = 0.0
 Identities = 325/534 (60%), Positives = 408/534 (76%), Gaps = 1/534 (0%)

Query: 45  NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANV 104
           ++ +P  FNFA+DVLD W+  EK G+R  +PALWWVNGKG E+ W+FREL   S++AAN+
Sbjct: 37  HQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANI 96

Query: 105 LTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKC 164
           L+  CGLQRGDR+AV+LPR+PEWWLV + CIR G+IFMPGTIQ+ + DILYRL+ SKAK 
Sbjct: 97  LSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKA 156

Query: 165 IVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPM 224
           IVA +EV   V+++  ECP L+ KLLVS +S +GWL+F++L   AS  H CVETGSQE  
Sbjct: 157 IVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS 216

Query: 225 TIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFS 284
            IYFTSGT+G PKMA+HS SSLG+   +    W  L++SDI+W +SDTGW+   +GS+  
Sbjct: 217 AIYFTSGTSGLPKMAEHSYSSLGLKAKMDAG-WTGLQASDIMWTISDTGWILNILGSLLE 275

Query: 285 SWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCL 344
           SW  GAC FVH + +FD    L TL++YPI ++   P VYRML+Q+DL  YKF  L++CL
Sbjct: 276 SWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCL 335

Query: 345 TGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQII 404
            GGE L PE LE WR QTGL++ E YGQTE G+ C   K  +IKPG MG     YDVQ+I
Sbjct: 336 AGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI 395

Query: 405 DENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGY 464
           D+ GNVLPPG EG+I +R+KP RP   FS YV+NP KTAA IRGDF++ GDRG+ D DGY
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGY 455

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           F F+GRADD+I SSGYRIGP EVE+AL++HPAVVE+AV+SSPD +RGEVVKAFV+LA+ F
Sbjct: 456 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 515

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWR 578
            S++PE+LT ELQ HVK  TAPYKYPRK+EFV  LPKT+TGKI+R  LRD+EW+
Sbjct: 516 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWK 569


>gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo
           sapiens]
          Length = 577

 Score =  683 bits (1762), Expect = 0.0
 Identities = 327/534 (61%), Positives = 406/534 (76%), Gaps = 1/534 (0%)

Query: 45  NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANV 104
           ++ +P  FNFA+DVLD W+  EK G+R  +PALWWVNGKG E+ W+FREL   S++AANV
Sbjct: 37  HQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANV 96

Query: 105 LTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKC 164
           L+  CGLQRGDR+AV+LPR+PEWWLV + CIR G+IFMPGTIQ+ + DILYRL+ SKAK 
Sbjct: 97  LSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKA 156

Query: 165 IVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPM 224
           IVA +EV   V+++  ECP L+ KLLVS +S +GWL+F++L   AS  H CVETGSQE  
Sbjct: 157 IVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS 216

Query: 225 TIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFS 284
            IYFTSGT+G PKMA+HS SSLG+   +    W  L++SDI+W +SDTGW+   + S+  
Sbjct: 217 AIYFTSGTSGLPKMAEHSYSSLGLKAKMDAG-WTGLQASDIMWTISDTGWILNILCSLME 275

Query: 285 SWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCL 344
            W  GAC FVH + +FD    L TL++YPI ++   P VYRML+Q+DL  YKF  L++C+
Sbjct: 276 PWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCV 335

Query: 345 TGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQII 404
           T GE L PE LE WR QTGL++ E YGQTE G+ C   K  +IKPG MG     YDVQII
Sbjct: 336 TVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQII 395

Query: 405 DENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGY 464
           D+ GNVLPPG EG+I +R+KP RP   FS YVDNP KTAA IRGDF++ GDRG+ D DGY
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGY 455

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           F F+GRADD+I SSGYRIGP EVE+AL+EHPAVVE+AV+SSPD +RGEVVKAFVVLA+ F
Sbjct: 456 FQFMGRADDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQF 515

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWR 578
            S++PE+LT ELQ HVK  TAPYKYPRK+EFV  LPKT+TGKI+R  LRD+EW+
Sbjct: 516 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWK 569


>gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo
           sapiens]
          Length = 577

 Score =  642 bits (1657), Expect = 0.0
 Identities = 317/568 (55%), Positives = 401/568 (70%), Gaps = 2/568 (0%)

Query: 10  FRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLDQWSQKEKTG 69
           FR +W        +H         +L++F A    +  +P+ FNFA+ VLD W+QKEK G
Sbjct: 7   FRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEG 66

Query: 70  ERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWL 129
           +R  NPA WWVNG+GDEVKWSFRE+G L+R+ ANV T+ CGLQ+GD LA++LPR+PEWWL
Sbjct: 67  KRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWL 126

Query: 130 VNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKL 189
           V V C+RTGIIF+P TI L AKDILYRL+ SKAK IV  + +A  V+SI  +CP LKTKL
Sbjct: 127 VAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKL 186

Query: 190 LVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIG 249
           LVS  S  GWL F+ L + AS EH+CV++ + +PM I+FTSGTTGFPKMA+HS   L + 
Sbjct: 187 LVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHG-LALQ 245

Query: 250 FTLCG-RYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDT 308
            +  G R    LK+SD+ W +SD+GW+ A I ++   W  G  VF+H + QFDT   + T
Sbjct: 246 PSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQT 305

Query: 309 LTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYE 368
           L  YPI       ++YRM++Q+D    +F +L HC TGGE + P+  E+W+ +TGL LYE
Sbjct: 306 LLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYE 365

Query: 369 GYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRP 428
            YGQ+E G+ICA   G +IKPG MGK   PYDVQ+ID+ G++LPP  EG I +R+KP RP
Sbjct: 366 NYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRP 425

Query: 429 FCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVE 488
              F  Y  +P+KTA    GDFY TGDRG MD +GY  F+GR+DD+I +SGYRIGP EVE
Sbjct: 426 VSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVE 485

Query: 489 SALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYK 548
           SAL+EHPAV ESAVV SPD IRGEVVKAF+VL   F S++ ++LT ELQ HVK  TAPYK
Sbjct: 486 SALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYK 545

Query: 549 YPRKVEFVQELPKTITGKIKRNVLRDQE 576
           YPRKVEFV ELPKTITGKI+R  LR +E
Sbjct: 546 YPRKVEFVSELPKTITGKIERKELRKKE 573


>gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 2 [Homo sapiens]
          Length = 571

 Score =  637 bits (1642), Expect = 0.0
 Identities = 311/534 (58%), Positives = 393/534 (73%), Gaps = 7/534 (1%)

Query: 45  NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANV 104
           ++ +P  FNFA+DVLD W+  EK G+R  +PALWWVNGKG E+ W+FREL   S++AANV
Sbjct: 37  HQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANV 96

Query: 105 LTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKC 164
           L+  CGLQRGDR+AV+LPR+PEWWLV + CIR G+IFMPGTIQ+ + DILYRL+ SKAK 
Sbjct: 97  LSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKA 156

Query: 165 IVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPM 224
           IVA +EV   V+++  ECP L+ KLLVS +S +GWL+F++L   AS  H CVETGSQE  
Sbjct: 157 IVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS 216

Query: 225 TIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFS 284
            IYFTSGT+G PKMA+HS SSLG+   +    W  L++SDI+W +SDTGW+   +GS+  
Sbjct: 217 AIYFTSGTSGLPKMAEHSYSSLGLKAKM-DAGWTGLQASDIMWTISDTGWILNILGSLLE 275

Query: 285 SWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCL 344
           SW  GAC FVH + +FD    L TL++YPI ++   P VYRML+Q+DL  YKF  L++CL
Sbjct: 276 SWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCL 335

Query: 345 TGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQII 404
            GGE L PE LE WR QTGL++ E YGQTE G+ C   K  +IKPG MG     YDVQ+I
Sbjct: 336 AGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI 395

Query: 405 DENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGY 464
                V    + G++      T  FC    + +NP KTAA IRGDF++ GDRG+ D DGY
Sbjct: 396 ---AFVHGSPRAGDLGFAGTMTLSFC---GHQENPDKTAANIRGDFWLLGDRGIKDEDGY 449

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           F F+GRADD+I SSGYRIGP EVE+AL++HPAVVE+AV+SSPD +RGEVVKAFV+LA+ F
Sbjct: 450 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 509

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWR 578
            S++PE+LT ELQ HVK  TAPYKYPRK+EFV  LPKT+TGKI+R  LRD+EW+
Sbjct: 510 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWK 563


>gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 1 [Homo sapiens]
          Length = 571

 Score =  637 bits (1642), Expect = 0.0
 Identities = 311/534 (58%), Positives = 393/534 (73%), Gaps = 7/534 (1%)

Query: 45  NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANV 104
           ++ +P  FNFA+DVLD W+  EK G+R  +PALWWVNGKG E+ W+FREL   S++AANV
Sbjct: 37  HQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANV 96

Query: 105 LTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKC 164
           L+  CGLQRGDR+AV+LPR+PEWWLV + CIR G+IFMPGTIQ+ + DILYRL+ SKAK 
Sbjct: 97  LSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKA 156

Query: 165 IVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPM 224
           IVA +EV   V+++  ECP L+ KLLVS +S +GWL+F++L   AS  H CVETGSQE  
Sbjct: 157 IVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS 216

Query: 225 TIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFS 284
            IYFTSGT+G PKMA+HS SSLG+   +    W  L++SDI+W +SDTGW+   +GS+  
Sbjct: 217 AIYFTSGTSGLPKMAEHSYSSLGLKAKM-DAGWTGLQASDIMWTISDTGWILNILGSLLE 275

Query: 285 SWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCL 344
           SW  GAC FVH + +FD    L TL++YPI ++   P VYRML+Q+DL  YKF  L++CL
Sbjct: 276 SWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCL 335

Query: 345 TGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQII 404
            GGE L PE LE WR QTGL++ E YGQTE G+ C   K  +IKPG MG     YDVQ+I
Sbjct: 336 AGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVI 395

Query: 405 DENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGY 464
                V    + G++      T  FC    + +NP KTAA IRGDF++ GDRG+ D DGY
Sbjct: 396 ---AFVHGSPRAGDLGFAGTMTLSFC---GHQENPDKTAANIRGDFWLLGDRGIKDEDGY 449

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           F F+GRADD+I SSGYRIGP EVE+AL++HPAVVE+AV+SSPD +RGEVVKAFV+LA+ F
Sbjct: 450 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 509

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWR 578
            S++PE+LT ELQ HVK  TAPYKYPRK+EFV  LPKT+TGKI+R  LRD+EW+
Sbjct: 510 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWK 563


>gi|42544134 SA hypertension-associated homolog isoform 2 [Homo
           sapiens]
          Length = 438

 Score =  484 bits (1246), Expect = e-137
 Identities = 215/384 (55%), Positives = 294/384 (76%), Gaps = 1/384 (0%)

Query: 21  RRLHKDHQLWTPLTLADFEAINRCNR-PLPKNFNFAADVLDQWSQKEKTGERPANPALWW 79
           R LHKD++  TP   +++E++ +  +  +P+ FNFA DVLDQW+ KEK G++P+NPA WW
Sbjct: 26  RALHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWW 85

Query: 80  VNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGI 139
           +N  G+E++WSF ELGSLSRK AN+L++ C LQRGDR+ +ILPR+PEWWL NVAC+RTG 
Sbjct: 86  INRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGT 145

Query: 140 IFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGW 199
           + +PGT QLT KDILYRL++SKA CI+ ++ +APAV+++  +C +L +KL+VS  S  GW
Sbjct: 146 VLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGW 205

Query: 200 LSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLD 259
            + +EL + AS+ H+CV+T   E M I+FTSGT+G+PKM  H+ SS G+G ++ GR+WLD
Sbjct: 206 GNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLD 265

Query: 260 LKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCS 319
           L  SD++WN SDTGW K+A  SVFS W+ GACVF H + +F+  + L TL+ YPIT  CS
Sbjct: 266 LTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCS 325

Query: 320 PPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMIC 379
            PTVYRMLVQ D+  YKFKSL+HC++ GEP+ P+V E+WR +TGL++YEGYGQTE  +IC
Sbjct: 326 APTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLIC 385

Query: 380 ANQKGQEIKPGSMGKGMLPYDVQI 403
            N KG +IKPGSMGK    +DV++
Sbjct: 386 GNFKGMKIKPGSMGKPSPAFDVKV 409


>gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Homo
           sapiens]
          Length = 480

 Score =  451 bits (1161), Expect = e-127
 Identities = 216/434 (49%), Positives = 303/434 (69%), Gaps = 1/434 (0%)

Query: 50  KNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPC 109
           +NFNFA DVLDQWSQ EK G R   PALW V+ KG+E KWSF  +  LS+KAA++L+  C
Sbjct: 47  QNFNFAKDVLDQWSQLEKDGLRGPYPALWKVSAKGEEDKWSFERMTQLSKKAASILSDTC 106

Query: 110 GLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE 169
            L  GDRL +ILP  PE + + +AC+R GI F+PG+ QLTAK I Y+LR SKA+CIVA+E
Sbjct: 107 ALSHGDRLMIILPPTPEAYWICLACVRLGITFVPGSPQLTAKKIRYQLRMSKAQCIVANE 166

Query: 170 EVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFT 229
            +AP V S V +CP LKTKLLVS +S++GWL F++L Q A  + + + T SQ+PM I+FT
Sbjct: 167 AMAPVVNSAVSDCPTLKTKLLVSDKSYDGWLDFKKLIQVAPPKQTYMRTKSQDPMAIFFT 226

Query: 230 SGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCG 289
            GTTG PKM ++SQ  LG+GF+   R W+DL+ +D++W++ D      ++ +V  +W  G
Sbjct: 227 KGTTGAPKMVEYSQYGLGMGFSQASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTWFQG 286

Query: 290 ACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQ-KDLKRYKFKSLRHCLTGGE 348
           ACVF+  M  F  +T L+ L+ +PITTL + P +Y+ L+Q K    Y+FKSL+ C+  G 
Sbjct: 287 ACVFLCHMPTFCPETVLNVLSRFPITTLSANPEMYQELLQHKCFTSYRFKSLKQCVAAGG 346

Query: 349 PLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENG 408
           P++P V+E W+  T L++YEGYGQTE G++CA  K  ++KP S+GK + PY VQI+DEN 
Sbjct: 347 PISPGVIEDWKRITKLDIYEGYGQTETGLLCATSKTIKLKPSSLGKPLPPYIVQIVDENS 406

Query: 409 NVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFV 468
           N+LPPG+EG IA+R+K  +P   +  ++ + ++ A+      Y+TGDRG+MD DGYFW+ 
Sbjct: 407 NLLPPGEEGNIAIRIKLNQPASLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYFWWS 466

Query: 469 GRADDVIISSGYRI 482
           GR DDV  + G R+
Sbjct: 467 GRVDDVANALGQRL 480


>gi|253970489 acyl-CoA synthetase short-chain family member 2
           isoform 2 [Homo sapiens]
          Length = 714

 Score =  187 bits (476), Expect = 2e-47
 Identities = 169/589 (28%), Positives = 265/589 (44%), Gaps = 77/589 (13%)

Query: 53  NFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQ 112
           N   +VLD+   ++K G++ A    W  N  G+  + ++ +L     + +NVL K  G+Q
Sbjct: 102 NICYNVLDRNVHEKKLGDKVA--FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQ 158

Query: 113 RGDRLAVILPRIPEWWLVNVACIRTG----IIFMPGTIQ-------------LTAKDILY 155
           +GDR+A+ +P IPE  +  +AC R G    I+F   + +             L   D  Y
Sbjct: 159 KGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFY 218

Query: 156 R--------------LRASKAK------CIVASE---------EVAPAVESIVLECPDLK 186
           R              L+  + K      CIV            +       I   CPD++
Sbjct: 219 RGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ 278

Query: 187 TKLL-----VSPQ-SWNGWLS--FQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKM 238
            KL      V PQ SWN  +   + EL Q A +E       +++P+ I +TSG+TG PK 
Sbjct: 279 GKLKEKSKRVQPQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKG 338

Query: 239 AQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGAC--VFVHR 296
             H+     +      +Y  D  + D+ W  +D GW+       +     GA   +F   
Sbjct: 339 VVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGI 398

Query: 297 MAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQ---KDLKRYKFKSLRHCLTGGEPLNPE 353
               D +     +  Y +T   + PT  R+L++   + + ++   SL+   T GEP+NPE
Sbjct: 399 PTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPE 458

Query: 354 VLEQWRVQTGLE---LYEGYGQTEVG--MICANQKGQEIKPGSMGKGMLPYDVQIIDENG 408
               +    G +   + + + QTE G  M+        +KPGS           I++E+G
Sbjct: 459 AWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESG 518

Query: 409 NVLPPGKEGEIALRLKPTRPFCFFSKYV-DNPQKTAATIRGDF---YVTGDRGVMDSDGY 464
             L    EG +  +    +P+    + V  N ++   T    F   YVTGD    D DGY
Sbjct: 519 EELEGEAEGYLVFK----QPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGY 574

Query: 465 FWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPF 524
           +W  GR DD++  SG+ +   EVESAL+EH AV E+AVV  P  ++GE +  FV L    
Sbjct: 575 YWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTL-CDG 633

Query: 525 KSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLR 573
            +++P KLT EL+  +++   P   P  ++    LPKT +GKI R VLR
Sbjct: 634 HTFSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 681


>gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo
           sapiens]
          Length = 689

 Score =  187 bits (476), Expect = 2e-47
 Identities = 160/551 (29%), Positives = 257/551 (46%), Gaps = 40/551 (7%)

Query: 53  NFAADVLDQWSQKEKTGERPANPALWWVNGK-GDEVKWSFRELGSLSRKAANVLTKPCGL 111
           N + + LDQ  +K      P + AL W   + G EV+ ++REL   + + AN L K  G+
Sbjct: 109 NVSVNCLDQHVRKS-----PESVALIWERDEPGTEVRITYRELLETTCRLANTL-KRHGV 162

Query: 112 QRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE-- 169
            RGDR+A+ +P  P      +AC R G +        +A+ +  R+  +K K ++     
Sbjct: 163 HRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQG 222

Query: 170 -------EVAPAVESIVLECPDLKTKLLVSPQSWN----GWLSFQELFQFASEEHSCV-- 216
                  E+   V+  V  CP ++  +LV+ ++ N    G L      + A E+  C   
Sbjct: 223 LRGGRVVELKKIVDEAVKHCPTVQ-HVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPE 281

Query: 217 ETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVK 276
             GS++ + + +TSG+TG PK   H+Q+   +   L  +   D +  DI   ++D GW+ 
Sbjct: 282 SMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWIT 341

Query: 277 AAIGSVFSSWLCGAC--VFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKD--- 331
                V+     GA   +F       +   + +T+    I      PT  R+L++     
Sbjct: 342 GHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAW 401

Query: 332 LKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTG---LELYEGYGQTEVGMICA----NQKG 384
           +K+Y   SLR   + GEP+N E  E      G     L + + QTE G IC     +++G
Sbjct: 402 VKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEG 461

Query: 385 QEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAA 444
            EI P    +        ++DE G+V+  G     AL +    P    + Y D+ +   A
Sbjct: 462 AEILPAMAMRPFFGIVPVLMDEKGSVVE-GSNVSGALCISQAWPGMARTIYGDHQRFVDA 520

Query: 445 TIRG--DFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAV 502
             +    +Y TGD       GY+   GR DDVI  SG+R+G  E+E A+ +HPAV ESAV
Sbjct: 521 YFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580

Query: 503 VSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKT 562
           +  P  I+GE   AF+V+     + + + +  EL+  V    A Y  P ++  V+ LPKT
Sbjct: 581 IGYPHDIKGEAAFAFIVVKD--SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKT 638

Query: 563 ITGKIKRNVLR 573
            +GK+ R +LR
Sbjct: 639 RSGKVMRRLLR 649


>gi|8923896 acyl-CoA synthetase short-chain family member 2 isoform
           1 [Homo sapiens]
          Length = 701

 Score =  183 bits (464), Expect = 4e-46
 Identities = 158/576 (27%), Positives = 260/576 (45%), Gaps = 64/576 (11%)

Query: 53  NFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQ 112
           N   +VLD+   ++K G++ A    W  N  G+  + ++ +L     + +NVL K  G+Q
Sbjct: 102 NICYNVLDRNVHEKKLGDKVA--FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQ 158

Query: 113 RGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE--- 169
           +GDR+A+ +P IPE  +  +AC R G +        +++ +  R+  S    ++ ++   
Sbjct: 159 KGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFY 218

Query: 170 ---------EVA------------PAVESIVL---------------ECPDLKTKLLVSP 193
                    E+A            P    IV+               + P +K       
Sbjct: 219 RGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ 278

Query: 194 QSWNGWLS--FQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFT 251
            SWN  +   + EL Q A +E       +++P+ I +TSG+TG PK   H+     +   
Sbjct: 279 ISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVA 338

Query: 252 LCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGAC--VFVHRMAQFDTDTFLDTL 309
              +Y  D  + D+ W  +D GW+       +     GA   +F       D +     +
Sbjct: 339 TTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIV 398

Query: 310 TTYPITTLCSPPTVYRMLVQ---KDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLE- 365
             Y +T   + PT  R+L++   + + ++   SL+   T GEP+NPE    +    G + 
Sbjct: 399 DKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQR 458

Query: 366 --LYEGYGQTEVG--MICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIAL 421
             + + + QTE G  M+        +KPGS           I++E+G  L    EG +  
Sbjct: 459 CPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVF 518

Query: 422 RLKPTRPFCFFSKYV-DNPQKTAATIRGDF---YVTGDRGVMDSDGYFWFVGRADDVIIS 477
           +    +P+    + V  N ++   T    F   YVTGD    D DGY+W  GR DD++  
Sbjct: 519 K----QPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV 574

Query: 478 SGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQ 537
           SG+ +   EVESAL+EH AV E+AVV  P  ++GE +  FV L     +++P KLT EL+
Sbjct: 575 SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTL-CDGHTFSP-KLTEELK 632

Query: 538 DHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLR 573
             +++   P   P  ++    LPKT +GKI R VLR
Sbjct: 633 KQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668


>gi|13375727 acyl-CoA synthetase short-chain family member 3 [Homo
           sapiens]
          Length = 686

 Score =  161 bits (407), Expect = 2e-39
 Identities = 143/537 (26%), Positives = 229/537 (42%), Gaps = 49/537 (9%)

Query: 81  NGKGDEVK-------------WSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEW 127
           NGKGD++              ++++E+     K A VL K  G+++GD + + +P IP+ 
Sbjct: 123 NGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQA 181

Query: 128 WLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE---------EVAPAVESI 178
               +AC R G I         +K++  R+   K K +V +          E  P VE  
Sbjct: 182 MYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEA 241

Query: 179 VLECPDLKTKLLVS--------PQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTS 230
           +        K+L+         P +    L + E    A + H CV   S+ P+ I +TS
Sbjct: 242 LKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKA-QSHDCVPVLSEHPLYILYTS 300

Query: 231 GTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGA 290
           GTTG PK          +           L+  ++ W  SD GWV       +   L G 
Sbjct: 301 GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN 360

Query: 291 CVFVHR---MAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDL-----KRYKFKSLRH 342
              ++    +   D   +   L  + +  L + PT  R + Q+D      K+Y     + 
Sbjct: 361 TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT 420

Query: 343 CLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGM-ICANQKG----QEIKPGSMGKGML 397
               GE  + E LE  +    + + + + QTE G  I A+  G    +   PG  GK + 
Sbjct: 421 LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP 480

Query: 398 PYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRG--DFYVTGD 455
            Y+V I+D+N   L     G I ++L P  P  F   + +              +Y T D
Sbjct: 481 GYNVMILDDNMQKLKARCLGNIVVKL-PLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMD 539

Query: 456 RGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVK 515
            G MD +GY + + R DDVI  +G+RI    +E +++ H  V + AVV   D ++G V  
Sbjct: 540 AGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPL 599

Query: 516 AFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
           A  VL     +   E++  E+  HV+++  P    R   FV++LPKT +GKI R+ L
Sbjct: 600 ALCVLRKDINA-TEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655


>gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score =  133 bits (335), Expect = 4e-31
 Identities = 136/525 (25%), Positives = 233/525 (44%), Gaps = 64/525 (12%)

Query: 90  SFRELGSLSRKAANVLTKPCGLQRGD----RLAVILPRIPEWWLVNVACIRTGIIFMPGT 145
           ++REL S S + +  + + CG   GD    R++ +      + +   A   +G + +P  
Sbjct: 67  TYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLY 126

Query: 146 IQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLL-VSPQSWNGWLSFQE 204
            +  A  + Y +  S++  ++AS+E    +  +V +   L   LL ++P  + G  + +E
Sbjct: 127 RKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRK---LGVPLLPLTPAIYTG--AVEE 181

Query: 205 LFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSD 264
             +    E      G+     I +TSGTTG PK    +  ++    T     W   K  D
Sbjct: 182 PAEVPVPEQGWRNKGAM----IIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWAWTKD-D 236

Query: 265 IIWNMSDTGWVKAAIGSVFSS-WLCGACVFVHRMA-QFDTDTFLDTLTTYPITTLCSPPT 322
           +I ++     V   + ++    W+   CV +   + Q   + FL + T   I    + PT
Sbjct: 237 VILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPR-INVFMAVPT 295

Query: 323 VYRMLV------------QKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGY 370
           +Y  L+            Q  L+    + +R  ++G   L   VLE+W+  TG  L E Y
Sbjct: 296 IYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERY 355

Query: 371 GQTEVGMICANQKGQEIK-PGSMGKGMLPYDVQIIDEN-----------------GNVLP 412
           G TE+GM  +      ++ PGS+G  +    V+I+ EN                 G  + 
Sbjct: 356 GMTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVT 415

Query: 413 PG---KEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGD-FYVTGDRGVMDSDGYFWFV 468
           PG   KEGE+ +R         F +Y + P++T +    D ++ TGD  V+  DG +W  
Sbjct: 416 PGFEEKEGELLVRGPSV-----FREYWNKPEETKSAFTLDGWFKTGDT-VVFKDGQYWIR 469

Query: 469 GRAD-DVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSY 527
           GR   D+I + GY++   EVE  L+ HP++ + AV+  PD   G+ V A V L       
Sbjct: 470 GRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLS 529

Query: 528 NPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
           +      EL++  +   APY  P ++  V+E+P+   GKI +  L
Sbjct: 530 H-----RELKEWARNVLAPYAVPSELVLVEEIPRNQMGKIDKKAL 569


>gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score =  133 bits (335), Expect = 4e-31
 Identities = 136/525 (25%), Positives = 233/525 (44%), Gaps = 64/525 (12%)

Query: 90  SFRELGSLSRKAANVLTKPCGLQRGD----RLAVILPRIPEWWLVNVACIRTGIIFMPGT 145
           ++REL S S + +  + + CG   GD    R++ +      + +   A   +G + +P  
Sbjct: 67  TYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLY 126

Query: 146 IQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLL-VSPQSWNGWLSFQE 204
            +  A  + Y +  S++  ++AS+E    +  +V +   L   LL ++P  + G  + +E
Sbjct: 127 RKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRK---LGVPLLPLTPAIYTG--AVEE 181

Query: 205 LFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSD 264
             +    E      G+     I +TSGTTG PK    +  ++    T     W   K  D
Sbjct: 182 PAEVPVPEQGWRNKGAM----IIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWAWTKD-D 236

Query: 265 IIWNMSDTGWVKAAIGSVFSS-WLCGACVFVHRMA-QFDTDTFLDTLTTYPITTLCSPPT 322
           +I ++     V   + ++    W+   CV +   + Q   + FL + T   I    + PT
Sbjct: 237 VILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPR-INVFMAVPT 295

Query: 323 VYRMLV------------QKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGY 370
           +Y  L+            Q  L+    + +R  ++G   L   VLE+W+  TG  L E Y
Sbjct: 296 IYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERY 355

Query: 371 GQTEVGMICANQKGQEIK-PGSMGKGMLPYDVQIIDEN-----------------GNVLP 412
           G TE+GM  +      ++ PGS+G  +    V+I+ EN                 G  + 
Sbjct: 356 GMTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVT 415

Query: 413 PG---KEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGD-FYVTGDRGVMDSDGYFWFV 468
           PG   KEGE+ +R         F +Y + P++T +    D ++ TGD  V+  DG +W  
Sbjct: 416 PGFEEKEGELLVRGPSV-----FREYWNKPEETKSAFTLDGWFKTGDT-VVFKDGQYWIR 469

Query: 469 GRAD-DVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSY 527
           GR   D+I + GY++   EVE  L+ HP++ + AV+  PD   G+ V A V L       
Sbjct: 470 GRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLS 529

Query: 528 NPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
           +      EL++  +   APY  P ++  V+E+P+   GKI +  L
Sbjct: 530 H-----RELKEWARNVLAPYAVPSELVLVEEIPRNQMGKIDKKAL 569


>gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]
          Length = 615

 Score =  124 bits (312), Expect = 2e-28
 Identities = 143/527 (27%), Positives = 225/527 (42%), Gaps = 50/527 (9%)

Query: 85  DEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPG 144
           ++V+ +F +L     KAA+ L    GL +GDRL +  P    W L+ +A  + GII +  
Sbjct: 96  EDVRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSV 154

Query: 145 TIQLTAKDILYRLRASKAKCIV------------ASEEVAPAVESIV------LECPDLK 186
                A ++ Y L+    K +V              +++ P VE+           PDL 
Sbjct: 155 NPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLT 214

Query: 187 TKLLVSPQSWNGWLSFQELFQFASEEHSCVET-------GSQEPMTIYFTSGTTGFPKMA 239
           T + V      G L   E+    S      +           +P+ I FTSGTTG PK A
Sbjct: 215 TVISVDAPL-PGTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGA 273

Query: 240 QHSQSSLGIGFTLCG-RYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLC---GACVFVH 295
             S  ++     + G R  L  K+ + +  M     +   +GSV  + +C   GA + + 
Sbjct: 274 TLSHYNIVNNSNILGERLKLHEKTPEQL-RMILPNPLYHCLGSVAGTMMCLMYGATLILA 332

Query: 296 RMAQFDTDTFLDTLTTYPITTLCSPPTVY-RMLVQKDLKRYKFKSLRHCLTGGEPLNPEV 354
               F+    L+ ++    T L   PT++  +L Q D   Y   ++   +  G P  PE+
Sbjct: 333 SPI-FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPEL 391

Query: 355 LEQWRVQTGL-ELYEGYGQTE---VGMICANQKGQEIKPGSMGKGMLPYDVQIID-ENGN 409
           +     +  + +L   YG TE   V      +   E K  S+G+ M   + +I++ E G 
Sbjct: 392 IRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGT 451

Query: 410 VLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGD-FYVTGDRGVMDSDGYFWFV 468
           +      GE+ +R      +C    Y   PQKT   +  D +Y TGD   M+  G+   V
Sbjct: 452 LAKLNTPGELCIR-----GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIV 506

Query: 469 GRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYN 528
           GR+ D+II  G  I P E+E     HP V E  VV   D   GE + A + L        
Sbjct: 507 GRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL-----KDG 561

Query: 529 PEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQ 575
            E    E++   K   + +K P+ + FV   P TI+GKI++  LR+Q
Sbjct: 562 EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 608


>gi|38524616 solute carrier family 27, member 1 [Homo sapiens]
          Length = 646

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 129/519 (24%), Positives = 214/519 (41%), Gaps = 51/519 (9%)

Query: 89  WSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQL 148
           W+F +L + S   AN L +  G   GD +A+ L   PE+  + +   + G+      + L
Sbjct: 104 WTFAQLDAYSNAVAN-LFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNL 162

Query: 149 TAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQF 208
             + + + L  S AK ++   E+  AV  +         K         G L    L   
Sbjct: 163 RREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDP 222

Query: 209 ASEEHSCV------ETGSQEPMTIYFTSGTTGFPKMA--QHSQSSLGIGFTLCGRYWLDL 260
             +E S          G  + +   +TSGTTG PK A   HS+      F   G +   +
Sbjct: 223 LLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAF---GHHAYRM 279

Query: 261 KSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSP 320
           +++D++++          I  V    + G  V + +  +F    F D    Y  T +   
Sbjct: 280 QAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRK--KFSASRFWDDCIKYNCTVVQYI 337

Query: 321 PTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGL-ELYEGYGQTEVGMIC 379
             + R L+++ ++  + +  R  L  G  L P + E++  + G+ ++ E YG TE     
Sbjct: 338 GEICRYLLKQPVREAERRH-RVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSI 396

Query: 380 ANQKGQEIKPGSMG--KGMLP--YDVQII-----------DENGNVLP--PGKEGEIALR 422
           AN  G   K GS G    +LP  Y ++++           D  G  +P   G+ G +  +
Sbjct: 397 ANMDG---KVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQ 453

Query: 423 LKPTRPFCFFSKYVDNP---QKTAATI--RGDF-YVTGDRGVMDSDGYFWFVGRADDVII 476
           +    P   F  YV      +K A ++  +GD  Y++GD  VMD  GY +F  R+ D   
Sbjct: 454 INQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFR 513

Query: 477 SSGYRIGPFEVESALIEHPAVVESAV--VSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTL 534
             G  +   EVE  L       + AV  V+ P  + G+   A V  A P    +P  +  
Sbjct: 514 WRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPG-VEGKAGMAAV--ADPHSLLDPNAIYQ 570

Query: 535 ELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLR 573
           ELQ    K  APY  P  +  + ++  T T KI++  L+
Sbjct: 571 ELQ----KVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQ 605


>gi|40807357 solute carrier family 27 (fatty acid transporter),
           member 4 [Homo sapiens]
          Length = 643

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 122/527 (23%), Positives = 211/527 (40%), Gaps = 52/527 (9%)

Query: 83  KGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFM 142
           +G +  W+FR+L   S   AN L +  GL  GD  A+ +    E+  + +   + G+   
Sbjct: 96  EGTDTHWTFRQLDEYSSSVANFL-QARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAA 154

Query: 143 PGTIQLTAKDILYRLRASKAKCIVASEEVAPAV--------ESIVLECPDLKTKLLVSPQ 194
                L    +L+ L  S+A+ +V   E+A A+         S+ L C        V P 
Sbjct: 155 LINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPS 214

Query: 195 SWNGWLSFQELFQFASEE-HSCVETGSQEPMTIYFTSGTTGFPKMA--QHSQSSLGIGFT 251
           + +       L + A +   SC + G  + +   +TSGTTG PK A   HS+        
Sbjct: 215 TEH----LDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALV 270

Query: 252 LCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTT 311
               Y   ++ +DI+++          I  +    L G  V + +  +F    F D    
Sbjct: 271 Y---YGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRK--KFSASRFWDDCIK 325

Query: 312 YPITTLCSPPTVYRMLVQKDLKRYKFK-SLRHCLTGGEPLNPEVLEQWRVQTGL-ELYEG 369
           Y  T +     + R L+ +  +  + +  +R  L  G  L   +   +  +  + ++ E 
Sbjct: 326 YNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNG--LRQSIWTNFSSRFHIPQVAEF 383

Query: 370 YGQTEVGMICANQKGQEIKPGSMGKGM-LPYDVQIIDENGNVLP-------------PGK 415
           YG TE      N   Q    G   + +   Y ++++  N + +              PG+
Sbjct: 384 YGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGE 443

Query: 416 EGEIALRLKPTRPFCFFSKYVD---NPQKTAATI--RGD-FYVTGDRGVMDSDGYFWFVG 469
            G++  R+    P   F  Y++   N +K A  +  +GD  Y+TGD  VMD  GY +F  
Sbjct: 444 PGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRD 503

Query: 470 RADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKA-FVVLAAPFKSYN 528
           R  D     G  +   EVE  L     + + AV     ++ G   +A    +A+P  + +
Sbjct: 504 RTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGV--EVPGTEGRAGMAAVASPTGNCD 561

Query: 529 PEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQ 575
            E+    L+    K    Y  P  +  + EL KT T K ++  LR +
Sbjct: 562 LERFAQVLE----KELPLYARPIFLRLLPELHKTGTYKFQKTELRKE 604


>gi|227499619 solute carrier family 27 (fatty acid transporter),
           member 2 isoform 1 [Homo sapiens]
          Length = 620

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 123/539 (22%), Positives = 214/539 (39%), Gaps = 47/539 (8%)

Query: 66  EKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIP 125
           EK  + P  P L +     DE   ++ ++   S + A  L    GL++GD +A+++   P
Sbjct: 61  EKARQTPHKPFLLF----RDETL-TYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEP 115

Query: 126 EWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIV--LECP 183
            +  + +  ++ G         + AK +L+  +   AK ++ S E+  AVE I+  L+  
Sbjct: 116 AYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKD 175

Query: 184 DLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQ----EPMTIYFTSGTTGFPK-- 237
           D+    +    + +G  SF +     S E       S+     P    +TSGTTG PK  
Sbjct: 176 DVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAA 235

Query: 238 MAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRM 297
           M  H +   G G T        LK+ D+I+         A +  +    + GA + +   
Sbjct: 236 MITHQRIWYGTGLTFVS----GLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALR-- 289

Query: 298 AQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQ 357
            +F    F D    Y +T +     + R L     K    +  +  L  G  L  +V  Q
Sbjct: 290 TKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKP-NDRDHKVRLALGNGLRGDVWRQ 348

Query: 358 WRVQTG-LELYEGYGQTE--VG-MICANQKGQEIKPGSMGKGMLPYDV---------QII 404
           +  + G + +YE Y  TE  +G M  A + G   +   + K ++ YD+          + 
Sbjct: 349 FVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVR 408

Query: 405 DENGNV--LPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTA---ATIRGDFYV-TGDRGV 458
           DENG    +P G+ G +  ++    PF  ++      +K        +GD Y  +GD  +
Sbjct: 409 DENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLM 468

Query: 459 MDSDGYFWFVGRADDVIISSGYRIGPFEVES--ALIEHPAVVESAVVSSPDQIRGEVVKA 516
           +D + + +F  R  D     G  +   EV     L++    V    V  PD   G +  A
Sbjct: 469 VDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDH-EGRIGMA 527

Query: 517 FVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQ 575
            + +       N E    +L  H+      Y  PR +     +  T T K ++  L ++
Sbjct: 528 SIKM-----KENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEE 581


>gi|13236579 solute carrier family 27 member 3 [Homo sapiens]
          Length = 730

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 123/502 (24%), Positives = 199/502 (39%), Gaps = 76/502 (15%)

Query: 111 LQRGDRLAVILPRIPE----WWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIV 166
           L  G  +A++LP  PE    W+ +  A +RT   F+P  ++     +L+ LR+  A+ +V
Sbjct: 211 LSPGATVALLLPAGPEFLWLWFGLAKAGLRTA--FVPTALR--RGPLLHCLRSCGARALV 266

Query: 167 ASEEVAPAVESIVLECPDLKTKLL----VSPQSWNGWLSFQELFQFASEEHSCVETGSQE 222
            + E    +ES+  + P L+   L      P +    +S   L + ++E    V      
Sbjct: 267 LAPEF---LESLEPDLPALRAMGLHLWAAGPGTHPAGIS-DLLAEVSAEVDGPVPGYLSS 322

Query: 223 PMTI------YFTSGTTGFPKMAQHSQSSL----GIGFTLCGRYWLDLKSSDIIWNMSDT 272
           P +I       FTSGTTG PK A+ S   +    G  + LCG     +   D+I+     
Sbjct: 323 PQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCG-----VHQEDVIYLALPL 376

Query: 273 GWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLV-QKD 331
             +  ++  +      GA V +   ++F    F +    + +T       + R LV Q  
Sbjct: 377 YHMSGSLLGIVGCMGIGATVVL--KSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPP 434

Query: 332 LKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTG-LELYEGYGQTEVGMICANQKGQEIKPG 390
            K  +   +R  L  G  L P+  E++  + G L++ E YG TE  +   N  GQ    G
Sbjct: 435 SKAERGHKVR--LAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQR---G 489

Query: 391 SMGK-----------GMLPYDV----QIIDENGNVL--PPGKEGEIALRLKPTRPFCFFS 433
           ++G+            ++ YDV     I D  G+ +   PG+ G +   +    PF    
Sbjct: 490 AVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFL--- 546

Query: 434 KYVDNPQKTAATIRGD-------FYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFE 486
            Y   P+     +  D       F+ TGD  V D  G+  F  R  D     G  +   E
Sbjct: 547 GYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTE 606

Query: 487 VESAL--IEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKST 544
           V      ++    V    V+ P    G    A +VL  P          ++L  HV ++ 
Sbjct: 607 VAEVFEALDFLQEVNVYGVTVPGH-EGRAGMAALVLRPPHALD-----LMQLYTHVSENL 660

Query: 545 APYKYPRKVEFVQELPKTITGK 566
            PY  PR +   + L  T T K
Sbjct: 661 PPYARPRFLRLQESLATTETFK 682


>gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]
          Length = 672

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 116/529 (21%), Positives = 209/529 (39%), Gaps = 61/529 (11%)

Query: 82  GKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIF 141
           GK + VK +F EL       A  + K  G+++GDR+   LP         +A    G I+
Sbjct: 122 GKEEIVKVTFEELRQEVALFAAAMRK-MGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIW 180

Query: 142 MPGTIQLTAKDILYRLRASKAKCIVASEEVA---------PAVESIVLECPDLKTKLLVS 192
              +       +L R    + K I + E V            ++ +V   PDLK K++V 
Sbjct: 181 SSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLK-KVVVI 239

Query: 193 PQSWNGWLSFQELFQFASEEHSC-----VETGSQE--------------PMTIYFTSGTT 233
           P     ++S +E    +   +S      + TG+ E              P+ I F+SGTT
Sbjct: 240 P-----YVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTT 294

Query: 234 GFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVF 293
           G PK   HS     I          ++ SSDI+   +  GW       +  +W+      
Sbjct: 295 GAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGW-------MMWNWMVSLLAT 347

Query: 294 VHRMAQFD-------TDTFLDTLTTYPITTLCSPPTVYRMLVQKDLK---RYKFKSLRHC 343
              M  +D        +   D +    IT L +      +L +K +K    +  + L   
Sbjct: 348 GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI 407

Query: 344 LTGGEPLNPEVLEQ-WR-VQTGLELYEGYGQTE-VGMICANQKGQEIKPGSMGKGMLPYD 400
           L+ G PL  +  E  +R +++ + L    G T+ +     +     +  G +    L   
Sbjct: 408 LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA 467

Query: 401 VQIIDENGNVLPPGKEGE-IALRLKPTRPFCFFSKYVDNPQKTAATIR-GDFYVTGDR-G 457
           V+  +E G  +  G+ GE +  +  P +P  F++    N  + A   +    +  GD   
Sbjct: 468 VEAWNEEGKAV-WGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCR 526

Query: 458 VMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAF 517
           +    G    +GR+D  +  +G R G  E+ + +     V +S  V   ++ R E V  F
Sbjct: 527 INPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILF 586

Query: 518 VVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGK 566
           + +A+   ++ P+ L   ++D ++   +    P  +   + +P T+ GK
Sbjct: 587 LKMASG-HAFQPD-LVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGK 633


>gi|62865631 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 114/518 (22%), Positives = 203/518 (39%), Gaps = 54/518 (10%)

Query: 89  WSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQL 148
           ++++++   S + A+V      L++GD +A+++   P++  V     + G +       +
Sbjct: 80  YTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNI 139

Query: 149 TAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLV------SPQSWNGWLSF 202
            +  +L  +RA   + +V   ++   VE I+   P L   + V       PQ   G +S 
Sbjct: 140 RSNSLLNCIRACGPRALVVGADLLGTVEEIL---PSLSENISVWGMKDSVPQ---GVISL 193

Query: 203 QELFQFASEE-----HSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYW 257
           +E    + +E     H  V       + I FTSGTTG PK A  SQ  +  G  +   + 
Sbjct: 194 KEKLSTSPDEPVPRSHHVVSLLKSTCLYI-FTSGTTGLPKAAVISQLQVLRGSAVLWAF- 251

Query: 258 LDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTL 317
               + DI++         AAI  +      GA   + +  +F    F      Y +T  
Sbjct: 252 -GCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKK--KFSASQFWSDCKKYDVTVF 308

Query: 318 CSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTG-LELYEGYGQTEVG 376
                + R L  K  KR   K  +  L  G  +  +V  ++  + G +++ E Y  TE  
Sbjct: 309 QYIGELCRYLC-KQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESS 367

Query: 377 MICANQKGQEIKPGSMGK-----------GMLPYDVQIIDENGNV------LPPGKEGEI 419
           +   N  G   + G++G+            ++ YD Q  +   N       +  G+ G +
Sbjct: 368 ISFMNYTG---RIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLL 424

Query: 420 ALRLKPTRPFC-FFSKYVDNPQKTAATI--RGDFYV-TGDRGVMDSDGYFWFVGRADDVI 475
             R+    PF  +   Y     K    +  +GD Y+ TGD  V D D + +F  R  D  
Sbjct: 425 ISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTF 484

Query: 476 ISSGYRIGPFEVESALIEHPAVVESAVVS-SPDQIRGEVVKAFVVLAAPFKSYNPEKLTL 534
              G  +   EV   +     + E+ V   +     G    A ++L  P  S + EK   
Sbjct: 485 RWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIIL-KPNTSLDLEK--- 540

Query: 535 ELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
            + + V      Y  PR +   +++  T T K+ ++ L
Sbjct: 541 -VYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQL 577


>gi|13325055 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 114/518 (22%), Positives = 203/518 (39%), Gaps = 54/518 (10%)

Query: 89  WSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQL 148
           ++++++   S + A+V      L++GD +A+++   P++  V     + G +       +
Sbjct: 80  YTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNI 139

Query: 149 TAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLV------SPQSWNGWLSF 202
            +  +L  +RA   + +V   ++   VE I+   P L   + V       PQ   G +S 
Sbjct: 140 RSNSLLNCIRACGPRALVVGADLLGTVEEIL---PSLSENISVWGMKDSVPQ---GVISL 193

Query: 203 QELFQFASEE-----HSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYW 257
           +E    + +E     H  V       + I FTSGTTG PK A  SQ  +  G  +   + 
Sbjct: 194 KEKLSTSPDEPVPRSHHVVSLLKSTCLYI-FTSGTTGLPKAAVISQLQVLRGSAVLWAF- 251

Query: 258 LDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTL 317
               + DI++         AAI  +      GA   + +  +F    F      Y +T  
Sbjct: 252 -GCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKK--KFSASQFWSDCKKYDVTVF 308

Query: 318 CSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTG-LELYEGYGQTEVG 376
                + R L  K  KR   K  +  L  G  +  +V  ++  + G +++ E Y  TE  
Sbjct: 309 QYIGELCRYLC-KQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESS 367

Query: 377 MICANQKGQEIKPGSMGK-----------GMLPYDVQIIDENGNV------LPPGKEGEI 419
           +   N  G   + G++G+            ++ YD Q  +   N       +  G+ G +
Sbjct: 368 ISFMNYTG---RIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLL 424

Query: 420 ALRLKPTRPFC-FFSKYVDNPQKTAATI--RGDFYV-TGDRGVMDSDGYFWFVGRADDVI 475
             R+    PF  +   Y     K    +  +GD Y+ TGD  V D D + +F  R  D  
Sbjct: 425 ISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTF 484

Query: 476 ISSGYRIGPFEVESALIEHPAVVESAVVS-SPDQIRGEVVKAFVVLAAPFKSYNPEKLTL 534
              G  +   EV   +     + E+ V   +     G    A ++L  P  S + EK   
Sbjct: 485 RWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIIL-KPNTSLDLEK--- 540

Query: 535 ELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
            + + V      Y  PR +   +++  T T K+ ++ L
Sbjct: 541 -VYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQL 577


>gi|57165412 acyl-CoA synthetase long-chain family member 6 isoform
           b [Homo sapiens]
          Length = 722

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/183 (27%), Positives = 82/183 (44%), Gaps = 15/183 (8%)

Query: 340 LRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPY 399
           +R  +TG  P +P VL   R   G ++YEGYGQTE    C      +   G +G  +   
Sbjct: 453 VRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCN 512

Query: 400 DVQIID-ENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYV-TGDRG 457
            ++++D E  N      EGEI +R  P      F  Y+ +P +T   +  D ++ TGD G
Sbjct: 513 HIKLVDVEELNYWACKGEGEICVR-GPN----VFKGYLKDPDRTKEALDSDGWLHTGDIG 567

Query: 458 VMDSDGYFWFVGRADDVI-ISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKA 516
                G    + R   +  ++ G  + P ++E+  I    V +         + G+ +KA
Sbjct: 568 KWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQI-------YVHGDSLKA 620

Query: 517 FVV 519
           F+V
Sbjct: 621 FLV 623



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 36/152 (23%), Positives = 60/152 (39%), Gaps = 20/152 (13%)

Query: 117 LAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVE 176
           + V     PEW +V +AC    ++ +P    L    I Y +  +    ++  +   P   
Sbjct: 175 IGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDK---PQKA 231

Query: 177 SIVLE------CPDLKTKLLVSP---------QSWNGWL-SFQELFQFASEEHSCVETGS 220
            ++LE       P LK  +L+ P         Q     + S Q +     E H       
Sbjct: 232 VLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQ 291

Query: 221 QEPMTIY-FTSGTTGFPKMAQHSQSSLGIGFT 251
            + ++I  FTSGTTG PK A  +  ++   F+
Sbjct: 292 PDDLSIVCFTSGTTGNPKGAMLTHGNVVADFS 323


>gi|57165410 acyl-CoA synthetase long-chain family member 6 isoform
           a [Homo sapiens]
          Length = 722

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/183 (27%), Positives = 82/183 (44%), Gaps = 15/183 (8%)

Query: 340 LRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPY 399
           +R  +TG  P +P VL   R   G ++YEGYGQTE    C      +   G +G  +   
Sbjct: 453 VRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCN 512

Query: 400 DVQIID-ENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYV-TGDRG 457
            ++++D E  N      EGEI +R  P      F  Y+ +P +T   +  D ++ TGD G
Sbjct: 513 HIKLVDVEELNYWACKGEGEICVR-GPN----VFKGYLKDPDRTKEALDSDGWLHTGDIG 567

Query: 458 VMDSDGYFWFVGRADDVI-ISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKA 516
                G    + R   +  ++ G  + P ++E+  I    V +         + G+ +KA
Sbjct: 568 KWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQI-------YVHGDSLKA 620

Query: 517 FVV 519
           F+V
Sbjct: 621 FLV 623



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 36/152 (23%), Positives = 60/152 (39%), Gaps = 20/152 (13%)

Query: 117 LAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVE 176
           + V     PEW +V +AC    ++ +P    L    I Y +  +    ++  +   P   
Sbjct: 175 IGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDK---PQKA 231

Query: 177 SIVLE------CPDLKTKLLVSP---------QSWNGWL-SFQELFQFASEEHSCVETGS 220
            ++LE       P LK  +L+ P         Q     + S Q +     E H       
Sbjct: 232 VLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQ 291

Query: 221 QEPMTIY-FTSGTTGFPKMAQHSQSSLGIGFT 251
            + ++I  FTSGTTG PK A  +  ++   F+
Sbjct: 292 PDDLSIVCFTSGTTGNPKGAMLTHGNVVADFS 323


>gi|40807491 acyl-CoA synthetase long-chain family member 1 [Homo
           sapiens]
          Length = 698

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 15/183 (8%)

Query: 340 LRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPY 399
           +R  +TG  P++  VL   R   G + YEGYGQTE    C      +   G +G  M   
Sbjct: 428 VRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCN 487

Query: 400 DVQIID-ENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYV-TGDRG 457
            ++++D E  N +    EGE+ ++  P      F  Y+ +P KTA  +  D ++ TGD G
Sbjct: 488 LIKLVDVEEMNYMAAEGEGEVCVK-GPN----VFQGYLKDPAKTAEALDKDGWLHTGDIG 542

Query: 458 VMDSDGYFWFVGRADDVI-ISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKA 516
               +G    + R   +  ++ G  I P ++E+  +    V +  V        GE ++A
Sbjct: 543 KWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFV-------HGESLQA 595

Query: 517 FVV 519
           F++
Sbjct: 596 FLI 598


>gi|13325057 solute carrier family 27 (fatty acid transporter),
           member 5 [Homo sapiens]
          Length = 690

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 90/380 (23%), Positives = 156/380 (41%), Gaps = 46/380 (12%)

Query: 221 QEPMTIYFTSGTTGFPKMAQHSQS---SLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKA 277
           + P    +TSGTTG PK A  +      +    +L G       + D+++ +     V  
Sbjct: 287 RSPALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGA-----TADDVVYTVLPLYHVMG 341

Query: 278 AIGSVFSSWLCGA-CVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYK 336
            +  +      GA CV   +   F T  F D    + +T +     + R L     ++ +
Sbjct: 342 LVVGILGCLDLGATCVLAPK---FSTSCFWDDCRQHGVTVILYVGELLRYLCNIP-QQPE 397

Query: 337 FKSLRHCLTGGEPLNPEVLEQWRVQTG-LELYEGYGQTEVGMICANQKGQEIKPGSMGK- 394
            ++    L  G  L  +V E ++ + G + ++E YG TE  M   N  G   + G++GK 
Sbjct: 398 DRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVG---RCGALGKM 454

Query: 395 ----------GMLPYDVQ----IIDENGNVLPPG--KEGEIALRLKPTRPFCFFSKYVD- 437
                      ++ +D++    + D  G  +P G  + G +  ++   +PF  +    + 
Sbjct: 455 SCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGYRGPREL 514

Query: 438 NPQKTAATIR--GD-FYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESAL--I 492
           + +K    +R  GD +Y TGD   MD +G+ +F  R  D     G  +   EVE  L  +
Sbjct: 515 SERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQV 574

Query: 493 EHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK 552
           +    V    V  P    G+V  A V L AP ++++ EK    L  HV+     Y  P  
Sbjct: 575 DFLQQVNVYGVCVPG-CEGKVGMAAVQL-APGQTFDGEK----LYQHVRAWLPAYATPHF 628

Query: 553 VEFVQELPKTITGKIKRNVL 572
           +     +  T T K+ +  L
Sbjct: 629 IRIQDAMEVTSTFKLMKTRL 648


>gi|42794760 acyl-CoA synthetase long-chain family member 5 isoform
           b [Homo sapiens]
          Length = 683

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 98/431 (22%), Positives = 167/431 (38%), Gaps = 79/431 (18%)

Query: 125 PEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRAS-----------KAKCIVASEE--V 171
           PEW +  +AC    ++ +P    L  + I++ +  +           KA  ++ + E   
Sbjct: 143 PEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGF 202

Query: 172 APAVESIVLECP---DLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIY- 227
            P+++ I+L  P   DLK +     +S    LS  +      E        S E +++  
Sbjct: 203 TPSLKVIILMDPFDDDLKQR---GEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVIC 259

Query: 228 FTSGTTGFPKMAQHSQSSL---GIGFTLCGRYWLDLKSSDI-IWNMSDTGWVKAAIGSVF 283
           FTSGTTG PK A  +  ++      F  C  +  +    D+ I  +      +  + +V 
Sbjct: 260 FTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVV 319

Query: 284 SSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQK-------DLKRY- 335
            S  CGA V      Q D     D + T   T   + P +   +  K        LK++ 
Sbjct: 320 YS--CGARV---GFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFL 374

Query: 336 -------KFKSL---------------------------RHCLTGGEPLNPEVLEQWRVQ 361
                  KFK L                           R  +TG  P++  V+  +R  
Sbjct: 375 LKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAA 434

Query: 362 TGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIID-ENGNVLPPGKEGEIA 420
            G ++YE YGQTE    C      +   G +G  +    V++ D  + N      EGE+ 
Sbjct: 435 MGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVC 494

Query: 421 LRLKPTRPFCFFSKYVDNPQKTAATIRGDFYV-TGDRGVMDSDGYFWFVGRADDVI-ISS 478
             +K T     F  Y+ +P+KT   +  D ++ TGD G    +G    + R  ++  ++ 
Sbjct: 495 --IKGTN---VFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQ 549

Query: 479 GYRIGPFEVES 489
           G  I P ++E+
Sbjct: 550 GEYIAPEKIEN 560


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,121,441
Number of Sequences: 37866
Number of extensions: 1108991
Number of successful extensions: 2239
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2124
Number of HSP's gapped (non-prelim): 70
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.