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Search of human proteins with 122891870
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122891870 melanoma inhibitory activity family, member 3
[Homo sapiens]
(1907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 3820 0.0
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens] 282 2e-75
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens] 275 3e-73
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens] 274 7e-73
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens] 265 2e-70
gi|146262005 CTAGE family, member 6 [Homo sapiens] 242 2e-63
gi|56847634 hypothetical protein LOC441294 [Homo sapiens] 242 2e-63
gi|193290160 CTAGE family, member 4 [Homo sapiens] 239 1e-62
gi|224586773 hypothetical protein LOC643854 [Homo sapiens] 239 2e-62
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo... 226 2e-58
gi|229608967 spermatogenic leucine zipper 1 [Homo sapiens] 144 6e-34
gi|46094009 melanoma inhibitory activity 2 [Homo sapiens] 114 9e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 1e-18
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 91 1e-17
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 91 1e-17
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 90 2e-17
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 89 3e-17
gi|9910470 otoraplin precursor [Homo sapiens] 89 5e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 88 7e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 87 2e-16
gi|55770834 centromere protein F [Homo sapiens] 86 3e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 86 5e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 85 6e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 85 6e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 85 6e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 85 6e-16
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 85 6e-16
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 85 6e-16
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 85 8e-16
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 83 2e-15
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 3820 bits (9907), Expect = 0.0
Identities = 1907/1907 (100%), Positives = 1907/1907 (100%)
Query: 1 MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPD 60
MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPD
Sbjct: 1 MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPD 60
Query: 61 CRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDET 120
CRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDET
Sbjct: 61 CRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDET 120
Query: 121 DFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPE 180
DFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPE
Sbjct: 121 DFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPE 180
Query: 181 PVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKV 240
PVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKV
Sbjct: 181 PVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKV 240
Query: 241 PESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLE 300
PESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLE
Sbjct: 241 PESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLE 300
Query: 301 DDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNE 360
DDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNE
Sbjct: 301 DDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNE 360
Query: 361 EDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV 420
EDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV
Sbjct: 361 EDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV 420
Query: 421 PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQ 480
PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQ
Sbjct: 421 PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQ 480
Query: 481 DKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGML 540
DKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGML
Sbjct: 481 DKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGML 540
Query: 541 HEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDAL 600
HEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDAL
Sbjct: 541 HEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDAL 600
Query: 601 VNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQE 660
VNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQE
Sbjct: 601 VNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQE 660
Query: 661 RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKV 720
RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKV
Sbjct: 661 RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKV 720
Query: 721 EEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQ 780
EEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQ
Sbjct: 721 EEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQ 780
Query: 781 ETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE 840
ETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE
Sbjct: 781 ETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE 840
Query: 841 LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPE 900
LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPE
Sbjct: 841 LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPE 900
Query: 901 DDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLK 960
DDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLK
Sbjct: 901 DDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLK 960
Query: 961 SAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDD 1020
SAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDD
Sbjct: 961 SAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDD 1020
Query: 1021 IQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPE 1080
IQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPE
Sbjct: 1021 IQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPE 1080
Query: 1081 EPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVT 1140
EPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVT
Sbjct: 1081 EPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVT 1140
Query: 1141 PLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRT 1200
PLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRT
Sbjct: 1141 PLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRT 1200
Query: 1201 VLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD 1260
VLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD
Sbjct: 1201 VLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD 1260
Query: 1261 EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM 1320
EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM
Sbjct: 1261 EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM 1320
Query: 1321 NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ 1380
NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ
Sbjct: 1321 NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ 1380
Query: 1381 IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG 1440
IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG
Sbjct: 1381 IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG 1440
Query: 1441 GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRN 1500
GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRN
Sbjct: 1441 GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRN 1500
Query: 1501 SLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAV 1560
SLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAV
Sbjct: 1501 SLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAV 1560
Query: 1561 SAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAA 1620
SAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAA
Sbjct: 1561 SAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAA 1620
Query: 1621 NLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP 1680
NLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP
Sbjct: 1621 NLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP 1680
Query: 1681 LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSS 1740
LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSS
Sbjct: 1681 LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSS 1740
Query: 1741 SRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPL 1800
SRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPL
Sbjct: 1741 SRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPL 1800
Query: 1801 PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRL 1860
PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRL
Sbjct: 1801 PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRL 1860
Query: 1861 PPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCSQALKQSP 1907
PPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCSQALKQSP
Sbjct: 1861 PPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCSQALKQSP 1907
>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
Length = 761
Score = 282 bits (722), Expect = 2e-75
Identities = 236/780 (30%), Positives = 381/780 (48%), Gaps = 83/780 (10%)
Query: 1134 EEPASVTPLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASF 1193
EEP VTP LL+ + +VA LP+ ++P + YG PW+ V A +G +
Sbjct: 2 EEPG-VTPQPYLGLLLEEL-----RRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAV 55
Query: 1194 AIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRK 1253
FLWR+ V+ R+Y E++++ L +++E ++L++K S + KE + + E+
Sbjct: 56 LFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQ---KEYEGYEVESSL 112
Query: 1254 QNMILSDEAIKYKDKIKTLEK----NQEILDDTAKNLRVMLESEREQNVKNQDLISENKK 1309
++ EA + + T EK N E L+D L L+ E+ ++ + +L+++ K
Sbjct: 113 KDASFEKEATEAQSLEATCEKLNRSNSE-LEDEILCLEKELKEEKSKHSEQDELMADISK 171
Query: 1310 SIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIED 1369
I+ L+D S+ +E ++ +++EE++K EN++L++ ++QL QE E
Sbjct: 172 RIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEV 231
Query: 1370 WSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGN 1429
W + +EL++Q +FE S+ E L K+ +I LT LL+ + + +
Sbjct: 232 WKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE-----RLLKMKDWAAMLGEDIT 286
Query: 1430 DSDEL-----ANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVST 1484
D D L + E G + K +K+++ ++ ++ +E + + ++L T
Sbjct: 287 DDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKT 346
Query: 1485 KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYE 1544
K L + +K L+ ++ SLQ+ E+E + L+QK++++ ELYQ+ EM L +KL+ EE
Sbjct: 347 KEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENY 406
Query: 1545 RQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLK 1604
R E+E +LS DEK A EE++TY++R +++E+EL++T S++ QI +HEKKAH+NWL
Sbjct: 407 RLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLA 466
Query: 1605 ARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIV----------KPMPGKP-NTQ 1653
AR AER + + ++E A+ R KL E K +L+++P + PG P + Q
Sbjct: 467 ARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGRGSRGPGNPLDHQ 526
Query: 1654 NPPRRGPLSQNGSFGP--SPVSGGECSPP------LTVEPPVR--PLSA-TLNRRDMPRS 1702
RG S + P +P G SPP + PP + P SA R+D S
Sbjct: 527 ITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCS 586
Query: 1703 EFGSVDGPLPHPRWSAEASGKPSPS-DPGSGTATMMNSSSRGSSPTRVLDEGKVNMAPKG 1761
G + GP AE PS D G+ SSR + D G +N+
Sbjct: 587 NSGRLSGP-------AELRSFNMPSLDKMDGSMPSEMESSRNDTKD---DLGNLNV---- 632
Query: 1762 PPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPF---GPRPLPPPFGPGMRPPLG 1813
P +P + G G VPPP+ GP P GPF GP P PPP PG
Sbjct: 633 --PDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGP-PFPPP-PPGAMFGAS 688
Query: 1814 LREFAPGVPPGRRDLPLHPRGFLP--GHAPFRPLGSLGPREYFIPGTRLPPPTHGPQEYP 1871
F PG PG P R P G P+ P PR F P PP + G E+P
Sbjct: 689 RDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLP-----PRPGFFPP---PPHSEGRSEFP 740
>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
Length = 804
Score = 275 bits (703), Expect = 3e-73
Identities = 236/817 (28%), Positives = 385/817 (47%), Gaps = 114/817 (13%)
Query: 1134 EEPASVTPLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASF 1193
EEP VTP LL+ + +VA LP+ ++P + YG PW+ V A +G +
Sbjct: 2 EEPG-VTPQPYLGLLLEEL-----RRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAV 55
Query: 1194 AIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRK 1253
FLWR+ V+ R+Y E++++ L +++E ++L++K S + KE + + E+
Sbjct: 56 LFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQ---KEYEGYEVESSL 112
Query: 1254 QNMILSDEAIKYKDKIKTLEK----NQEILDDTAKNLRVMLESEREQNVKNQDLISENKK 1309
++ EA + + T EK N E L+D L L+ E+ ++ + +L+++ K
Sbjct: 113 KDASFEKEATEAQSLEATCEKLNRSNSE-LEDEILCLEKELKEEKSKHSEQDELMADISK 171
Query: 1310 SIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIED 1369
I+ L+D S+ +E ++ +++EE++K EN++L++ ++QL QE E
Sbjct: 172 RIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEV 231
Query: 1370 WSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGN 1429
W + +EL++Q +FE S+ E L K+ +I LT LL+ + + +
Sbjct: 232 WKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTE-----RLLKMKDWAAMLGEDIT 286
Query: 1430 DSDEL-----ANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVST 1484
D D L + E G + K +K+++ ++ ++ +E + + ++L T
Sbjct: 287 DDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKT 346
Query: 1485 KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYE 1544
K L + +K L+ ++ SLQ+ E+E + L+QK++++ ELYQ+ EM L +KL+ EE
Sbjct: 347 KEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENY 406
Query: 1545 RQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLK 1604
R E+E +LS DEK A EE++TY++R +++E+EL++T S++ QI +HEKKAH+NWL
Sbjct: 407 RLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLA 466
Query: 1605 ARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQN 1664
AR AER + + ++E A+ R KL E K +L+++P + PNT P +
Sbjct: 467 ARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYAL----DVPNTAFGREHSPYGPS 522
Query: 1665 GSFGPSPVSGGECSPPLTVEPPVR--PL-------------------------SATLNRR 1697
PS + SPP +E P+R PL ++ +R
Sbjct: 523 PLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRL 582
Query: 1698 DMPR---SEFGSVDGP--------LPHPRWSAEASGKP--------SPSDPGSGTATMMN 1738
P S+ GS+ P P P S S P S S SG A + +
Sbjct: 583 TDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRS 642
Query: 1739 ------SSSRGSSPTRVL--------DEGKVNMAPKGPPPFPGVPLMSTPMG-GPVPPPI 1783
GS P+ + D G +N+ P +P + G G VPPP+
Sbjct: 643 FNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNV------PDSSLPAENEATGPGFVPPPL 696
Query: 1784 R--YGP--PPQLCGPF---GPRPLPPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFL 1836
GP P GPF GP P PPP PG F PG PG P R
Sbjct: 697 APIRGPLFPVDARGPFLRRGP-PFPPP-PPGAMFGASRDYFPPGDFPGPPPAPFAMRNVY 754
Query: 1837 P--GHAPFRPLGSLGPREYFIPGTRLPPPTHGPQEYP 1871
P G P+ P PR F P PP + G E+P
Sbjct: 755 PPRGFPPYLP-----PRPGFFPP---PPHSEGRSEFP 783
>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
Length = 792
Score = 274 bits (700), Expect = 7e-73
Identities = 228/793 (28%), Positives = 376/793 (47%), Gaps = 108/793 (13%)
Query: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
+ +VA LP+ ++P + YG PW+ V A +G + FLWR+ V+ R+Y E++++
Sbjct: 8 EEVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLA 67
Query: 1218 EKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEK--- 1274
L +++E ++L++K S + KE + + E+ ++ EA + + T EK
Sbjct: 68 LMLSGLIEEKSKLLEKFSLVQ---KEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNR 124
Query: 1275 -NQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALN 1333
N E L+D L L+ E+ ++ + +L+++ K I+ L+D S+ +E ++
Sbjct: 125 SNSE-LEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFK 183
Query: 1334 EAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEV 1393
+++EE++K EN++L++ ++QL QE E W + +EL++Q +FE S+ E
Sbjct: 184 IFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQ 243
Query: 1394 ALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDEL-----ANGEVGGDRNEKMK 1448
L K+ +I LT LL+ + + + D D L + E G + K
Sbjct: 244 VLNDKESHIKTLTE-----RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPK 298
Query: 1449 NQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAG 1508
+K+++ ++ ++ +E + + ++L TK L + +K L+ ++ SLQ+
Sbjct: 299 GALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTH 358
Query: 1509 LEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKT 1568
E+E + L+QK++++ ELYQ+ EM L +KL+ EE R E+E +LS DEK A EE++T
Sbjct: 359 FENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELET 418
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
Y++R +++E+EL++T S++ QI +HEKKAH+NWL AR AER + + ++E A+ R KL E
Sbjct: 419 YRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTE 478
Query: 1629 LTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTVEPPVR 1688
K +L+++P + PNT P + PS + SPP +E P+R
Sbjct: 479 TELKFELLEKDPYAL----DVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLR 534
Query: 1689 --PL-------------------------SATLNRRDMPR---SEFGSVDGP-------- 1710
PL ++ +R P S+ GS+ P
Sbjct: 535 LSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMM 594
Query: 1711 LPHPRWSAEASGKP--------SPSDPGSGTATMMN------SSSRGSSPTRVL------ 1750
P P S S P S S SG A + + GS P+ +
Sbjct: 595 FPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDT 654
Query: 1751 --DEGKVNMAPKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPF---GPRPL 1800
D G +N+ P +P + G G VPPP+ GP P GPF GP P
Sbjct: 655 KDDLGNLNV------PDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGP-PF 707
Query: 1801 PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLP--GHAPFRPLGSLGPREYFIPGT 1858
PPP PG F PG PG P R P G P+ P PR F P
Sbjct: 708 PPP-PPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLP-----PRPGFFPP- 760
Query: 1859 RLPPPTHGPQEYP 1871
PP + G E+P
Sbjct: 761 --PPHSEGRSEFP 771
>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
Length = 775
Score = 265 bits (678), Expect = 2e-70
Identities = 224/783 (28%), Positives = 369/783 (47%), Gaps = 108/783 (13%)
Query: 1168 VQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKEN 1227
++P + YG PW+ V A +G + FLWR+ V+ R+Y E++++ L +++E
Sbjct: 1 MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
Query: 1228 TELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEK----NQEILDDTA 1283
++L++K S + KE + + E+ ++ EA + + T EK N E L+D
Sbjct: 61 SKLLEKFSLVQ---KEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSE-LEDEI 116
Query: 1284 KNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVK 1343
L L+ E+ ++ + +L+++ K I+ L+D S+ +E ++ +++EE++K
Sbjct: 117 LCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLK 176
Query: 1344 SECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNIN 1403
EN++L++ ++QL QE E W + +EL++Q +FE S+ E L K+ +I
Sbjct: 177 IAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 236
Query: 1404 ALTNCITQLNLLECESESEGQNKGGNDSDEL-----ANGEVGGDRNEKMKNQIKQMMDVS 1458
LT LL+ + + + D D L + E G + K +K+++ +
Sbjct: 237 TLTE-----RLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAA 291
Query: 1459 RTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQ 1518
+ ++ +E + + ++L TK L + +K L+ ++ SLQ+ E+E + L+Q
Sbjct: 292 KLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQ 351
Query: 1519 KVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMED 1578
K++++ ELYQ+ EM L +KL+ EE R E+E +LS DEK A EE++TY++R +++E+
Sbjct: 352 KLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEE 411
Query: 1579 ELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQE 1638
EL++T S++ QI +HEKKAH+NWL AR AER + + ++E A+ R KL E K +L++
Sbjct: 412 ELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEK 471
Query: 1639 EPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTVEPPVR--PL------ 1690
+P + PNT P + PS + SPP +E P+R PL
Sbjct: 472 DPYAL----DVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGG 527
Query: 1691 -------------------SATLNRRDMPR---SEFGSVDGP--------LPHPRWSAEA 1720
++ +R P S+ GS+ P P P S
Sbjct: 528 RGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPD 587
Query: 1721 SGKP--------SPSDPGSGTATMMN------SSSRGSSPTRVL--------DEGKVNMA 1758
S P S S SG A + + GS P+ + D G +N+
Sbjct: 588 SALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNV- 646
Query: 1759 PKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPF---GPRPLPPPFGPGMRP 1810
P +P + G G VPPP+ GP P GPF GP P PPP PG
Sbjct: 647 -----PDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGP-PFPPP-PPGAMF 699
Query: 1811 PLGLREFAPGVPPGRRDLPLHPRGFLP--GHAPFRPLGSLGPREYFIPGTRLPPPTHGPQ 1868
F PG PG P R P G P+ P PR F P PP + G
Sbjct: 700 GASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLP-----PRPGFFPP---PPHSEGRS 751
Query: 1869 EYP 1871
E+P
Sbjct: 752 EFP 754
>gi|146262005 CTAGE family, member 6 [Homo sapiens]
Length = 777
Score = 242 bits (618), Expect = 2e-63
Identities = 217/789 (27%), Positives = 368/789 (46%), Gaps = 103/789 (13%)
Query: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
+ +VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 20 RRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLG 79
Query: 1218 EKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 80 ATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLNRS 138
Query: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEA 1335
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I
Sbjct: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
Query: 1336 KLSEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVA 1394
K+SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E
Sbjct: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQV 258
Query: 1395 LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQM 1454
L K+++I LT + + E + + + + + E G + ++ +K +K++
Sbjct: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
Query: 1455 MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECK 1514
+ ++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E +
Sbjct: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQESLQSENIYFESENQ 378
Query: 1515 TLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIE 1574
L+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A E+++TY++ +
Sbjct: 379 KLQQKLKIMTEFYQEDEMKLYRKLTVEENYRIEEEEKLSKVEEKLSRATEQLETYRKLAK 438
Query: 1575 EMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMA 1634
++E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K
Sbjct: 439 DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
Query: 1635 MLQEEP---VIVKPMPGKPNTQNPPRRGPLSQNGS---------------FGPSPV--SG 1674
+L+++P + G+ + N P PL Q S G SPV G
Sbjct: 499 LLEKDPNALDVSNTAFGREHAPNGP--APLGQRSSETRAFLSPQTLLEDPLGLSPVLPEG 556
Query: 1675 GECSPPLTVEPPVRPLSATL-NRRDMPR-----------SEFGSVDGPL--------PHP 1714
G P P PL + N R P S+ GS+ P+ P P
Sbjct: 557 GGRGP----RGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPP 612
Query: 1715 RWSAEASGKP--------SPSDPGSGTAT----MMNSSSR--GSSPTRVL--------DE 1752
S S P S S+ SG+A M S + GS P+ + D
Sbjct: 613 GQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDL 672
Query: 1753 GKVNMAPKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPFGPRPLPPPFGPG 1807
G +N+ P +P + G G +PPP+ GP P GPF R PPF P
Sbjct: 673 GNLNV------PDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRR--GPPFPP- 723
Query: 1808 MRPPLGLREFAPGVPPGRRDLPLHPRGFL-PGHAPFRPLGSLGPREYFIPGTRLPPPTHG 1866
PP PG G PR F P HAPF PR LPP H
Sbjct: 724 --PP-------PGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPR-------GLPPYFHP 767
Query: 1867 PQEYPPPPA 1875
+ P PA
Sbjct: 768 RPGFYPNPA 776
>gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
Length = 777
Score = 242 bits (618), Expect = 2e-63
Identities = 217/789 (27%), Positives = 368/789 (46%), Gaps = 103/789 (13%)
Query: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
+ +VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 20 RRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLG 79
Query: 1218 EKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 80 ATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLNRS 138
Query: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEA 1335
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I
Sbjct: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
Query: 1336 KLSEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVA 1394
K+SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E
Sbjct: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQV 258
Query: 1395 LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQM 1454
L K+++I LT + + E + + + + + E G + ++ +K +K++
Sbjct: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
Query: 1455 MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECK 1514
+ ++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E +
Sbjct: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
Query: 1515 TLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIE 1574
L+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A E+++TY++ +
Sbjct: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK 438
Query: 1575 EMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMA 1634
++E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K
Sbjct: 439 DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
Query: 1635 MLQEEP---VIVKPMPGKPNTQNPPRRGPLSQNGS---------------FGPSPV--SG 1674
+L+++P + G+ + N P PL Q S G SPV G
Sbjct: 499 LLEKDPNALDVSNTAFGREHAPNGP--APLGQRSSETRAFLSPQTLLEDPLGLSPVLPEG 556
Query: 1675 GECSPPLTVEPPVRPLSATL-NRRDMPR-----------SEFGSVDGPL--------PHP 1714
G P P PL + N R P S+ GS+ P+ P P
Sbjct: 557 GGRGP----RGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPP 612
Query: 1715 RWSAEASGKP--------SPSDPGSGTAT----MMNSSSR--GSSPTRVL--------DE 1752
S S P S S+ SG+A M S + GS P+ + D
Sbjct: 613 GQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDL 672
Query: 1753 GKVNMAPKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPFGPRPLPPPFGPG 1807
G +N+ P +P + G G +PPP+ GP P GPF R PPF P
Sbjct: 673 GNLNV------PDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRR--GPPFPP- 723
Query: 1808 MRPPLGLREFAPGVPPGRRDLPLHPRGFL-PGHAPFRPLGSLGPREYFIPGTRLPPPTHG 1866
PP PG G PR F P HAPF PR LPP H
Sbjct: 724 --PP-------PGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPR-------GLPPYFHP 767
Query: 1867 PQEYPPPPA 1875
+ P PA
Sbjct: 768 RPGFYPNPA 776
>gi|193290160 CTAGE family, member 4 [Homo sapiens]
Length = 777
Score = 239 bits (611), Expect = 1e-62
Identities = 203/760 (26%), Positives = 361/760 (47%), Gaps = 86/760 (11%)
Query: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
+ +VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 20 RRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLG 79
Query: 1218 EKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 80 ATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLNRS 138
Query: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEA 1335
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I
Sbjct: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
Query: 1336 KLSEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVA 1394
K+SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E
Sbjct: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQV 258
Query: 1395 LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQM 1454
L K+++I LT + + E + + + + + E G + ++ +K +K++
Sbjct: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
Query: 1455 MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECK 1514
+ ++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E +
Sbjct: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
Query: 1515 TLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIE 1574
L+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A E ++TY++ +
Sbjct: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK 438
Query: 1575 EMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMA 1634
++E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K
Sbjct: 439 DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
Query: 1635 MLQEEPVIV--------------KPMP-GKPNTQ------------NPPRRGP-LSQNGS 1666
+L+++P + P P G+P+++ +P R P L G
Sbjct: 499 LLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGG 558
Query: 1667 FGPSPVSG----------GECSPPLTVEPPVRP-----LSATL--NRRDM-PRSEFGSVD 1708
GPS GE S ++P P LS+ + +RR M P D
Sbjct: 559 RGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPD 618
Query: 1709 GPLP---HPRWSAEASGKPSPSDPGSGTATMMNSSSRG------SSPTRVLDE-GKVNMA 1758
LP R+ + + P++P S T ++ R SS D+ G +N+
Sbjct: 619 STLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVP 678
Query: 1759 PKGPPPF-----PG-VPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRP-----------LP 1801
P PG +P P+ GP+ P GP + PF P P P
Sbjct: 679 DSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFP 738
Query: 1802 PPFGPG-MRPPLGLREFAP--GVPPGRRDLPLHPR-GFLP 1837
P PG P +R P G+PP LHPR GF P
Sbjct: 739 PRDFPGPPHAPFAMRNIYPPRGLPP-----YLHPRPGFYP 773
>gi|224586773 hypothetical protein LOC643854 [Homo sapiens]
Length = 777
Score = 239 bits (610), Expect = 2e-62
Identities = 204/758 (26%), Positives = 359/758 (47%), Gaps = 86/758 (11%)
Query: 1160 LVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEK 1219
+VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 22 VVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGAT 81
Query: 1220 LKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQE 1277
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 82 LSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLSRSNS 140
Query: 1278 ILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKL 1337
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I K+
Sbjct: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKM 200
Query: 1338 SEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVALT 1396
SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E L
Sbjct: 201 SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLN 260
Query: 1397 HKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMD 1456
K+++I LT + + E + + + + E G + ++ K +K+++
Sbjct: 261 DKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELKVNSQWENGANLDDPPKGALKKLIH 320
Query: 1457 VSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTL 1516
++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E + L
Sbjct: 321 AAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKL 380
Query: 1517 RQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEM 1576
+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A EE++TY++ +++
Sbjct: 381 QQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISHATEELETYRKLAKDL 440
Query: 1577 EDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAML 1636
E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K +L
Sbjct: 441 EEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTERELKFELL 500
Query: 1637 QEEPVIV--------------KPMP-GKPNTQ------------NPPRRGP-LSQNGSFG 1668
+++P + P P G+P+++ +P R P L G G
Sbjct: 501 EKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRG 560
Query: 1669 PSPVSG----------GECSPPLTVEPPVRP-----LSATL--NRRDM-PRSEFGSVDGP 1710
PS GE S ++P P LS+ + +RR M P D
Sbjct: 561 PSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDST 620
Query: 1711 LP---HPRWSAEASGKPSPSDPGSGTATMMNSSSRG------SSPTRVLDE-GKVNMAPK 1760
LP R+ + + P++P S T ++ R SS D+ G +N+
Sbjct: 621 LPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDS 680
Query: 1761 GPPPF-----PG-VPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRP-----------LPPP 1803
P PG +P P+ GP+ P GP + PF P P PP
Sbjct: 681 SLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPR 740
Query: 1804 FGPG-MRPPLGLREFAP--GVPPGRRDLPLHPR-GFLP 1837
PG P +R P G+PP LHPR GF P
Sbjct: 741 DFPGPPHAPFAMRNIYPPRGLPP-----YLHPRPGFYP 773
>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform 1
[Homo sapiens]
Length = 745
Score = 226 bits (576), Expect = 2e-58
Identities = 193/727 (26%), Positives = 333/727 (45%), Gaps = 55/727 (7%)
Query: 1168 VQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKEN 1227
++P YG PW+ V A G + +FLWR+ V R+Y E++ + L +++E
Sbjct: 1 MRPDSHPYGFPWELVIRAAVAGFFA-VLFLWRSFRSVTSRLYVRREKKFAVALSGLIEEK 59
Query: 1228 TELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEK----NQEILDDTA 1283
+L++K S + KE + + E+ +N EA + + T EK N E++ +
Sbjct: 60 CKLLEKFSLVQ---KEYEGYEVESSLKNASFEKEATEAQSLEATCEKLNRFNSELVHEIL 116
Query: 1284 KNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVK 1343
L L+ E+ ++ + +L+++ K I+ L+D S+ +E ++ + +EE+++
Sbjct: 117 C-LEKELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLE 175
Query: 1344 SECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNIN 1403
E +EN+ L++ ++QL QE E W + +EL +Q ++FE S+ E L K+++I
Sbjct: 176 IEIQDAWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIK 235
Query: 1404 ALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTA 1463
LT + ++ E + + + + + E G + K +K+++ ++ +
Sbjct: 236 TLTERLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNAS 295
Query: 1464 ISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL 1523
+ +E + + ++L TK L + +K L+ ++ SLQ+ E E + L+QK++++
Sbjct: 296 LKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVM 355
Query: 1524 NELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKT 1583
ELYQ+ EM L +KL EE R E+E +LS DE A EE++TY++R ++++ E +KT
Sbjct: 356 TELYQENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLK-EFEKT 414
Query: 1584 ERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIV 1643
++ +I HEKKAH+NW A AER + + ++E A+ R KL E+ K+ +L+++P +
Sbjct: 415 IHFYQKKIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGL 474
Query: 1644 KPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTVEPPVRPLSATLNRRDMPRSE 1703
PNT + P + PS + PP +E P+R LS L
Sbjct: 475 ----DVPNTAFGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLR-LSPLL--------- 520
Query: 1704 FGSVDGPLPHPRWSAEAS-GKPSPSDPGSGTATMMNSSSRGSSPTRVLDEGKVNMAPKGP 1762
PR S G +P D +S R + P R + P P
Sbjct: 521 ----------PRGGGRGSRGPGNPPDHQITKERGESSCDRLTDPHRAPSDA----GPLAP 566
Query: 1763 PPFPGVPLMSTPMGGPVP----PPIR----YGPPPQLCGPFGPRPLPPPFGPGM--RPPL 1812
P +M P G P PP R Y +L GP R P M P
Sbjct: 567 PWEQDYRMMFPPPGQSYPDSALPPQRQDRFYSNCARLSGPAELRSFNMPSLDKMDGSMPS 626
Query: 1813 GLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRLPPPTHGP----- 1867
+ +L + P LP G + P I G P T GP
Sbjct: 627 EMESSRNDTKDNLGNLKV-PDSSLPAENEATGPGFVPPPLAPIRGLLFPVDTRGPFIRRG 685
Query: 1868 QEYPPPP 1874
+PPPP
Sbjct: 686 PPFPPPP 692
>gi|229608967 spermatogenic leucine zipper 1 [Homo sapiens]
Length = 430
Score = 144 bits (364), Expect = 6e-34
Identities = 127/473 (26%), Positives = 225/473 (47%), Gaps = 66/473 (13%)
Query: 1163 TLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKT 1222
T+ V P PD + P A I S + W ++ +K+ +QVTEQQ ++K
Sbjct: 12 TISKTVNPTPDPHQEYLDPRITIALFEIGSHSPSSWGSLPFLKNSSHQVTEQQTAQKFNN 71
Query: 1223 IMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDT 1282
++KE ++++ ++ +E+KI E+K+ +ET ++++ +K+ I+ L+K E+L
Sbjct: 72 LLKEIKDILKNMAGFEEKITEAKELFEETN-----ITEDVSAHKENIRGLDKINEML--- 123
Query: 1283 AKNLRVMLESEREQNVKNQDLI------------SENKKSIEKLKDVISMNASEFSEVQI 1330
+ NL V L E+E N K Q++I EN + ++K+ +++S N + +
Sbjct: 124 STNLPVSLAPEKEDNEKKQEMILETNITEDVSAHKENIRGLDKINEMLSTN------LPV 177
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD 1390
+L K EK + ++ EN + + +++ + + L+E +S EK++
Sbjct: 178 SLAPEKEDNEKKQ----QMIMENQNSENTAQVFARDLVNRLEEKKVLNETQQSQEKAKNR 233
Query: 1391 LEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQ 1450
L V + + N + QL E+E +K + +L +K+
Sbjct: 234 LNV-----QEETMKIRNNMEQLL-----QEAEHWSKQHTELSKL------------IKSY 271
Query: 1451 IKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLE 1510
K D+S T V Q + VS K LE+QVKKL D SLQ A LE
Sbjct: 272 QKSQKDISETLGNNGVG------FQTQPNNEVSAKHELEEQVKKLSHDTYSLQLMAALLE 325
Query: 1511 DECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYK 1570
+EC+ L+Q+VEIL EL+ QK+ LQ+K Q Y++ ++ + S A++V+ YK
Sbjct: 326 NECQILQQRVEILKELHHQKQGTLQEKPIQINYKQDKKNQK--------PSEAKKVEMYK 377
Query: 1571 RRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLR 1623
+ + M+ K +RS ++ KKA A +A+ + R A++LR
Sbjct: 378 QNKQAMKGTFWKKDRSCRSLDVCLNKKACNTQFNIHVARKALRGKMRSASSLR 430
>gi|46094009 melanoma inhibitory activity 2 [Homo sapiens]
Length = 654
Score = 114 bits (285), Expect = 9e-25
Identities = 104/399 (26%), Positives = 174/399 (43%), Gaps = 36/399 (9%)
Query: 36 KLCADDECSMLMYRGEALEDFTGPDCRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFG 95
K C D EC L+ R A+ D+ GPDCR++NF KG+ + VY KLA ++WAGS G+ FG
Sbjct: 30 KKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFG 89
Query: 96 YFPKDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSE 155
YFP+D +Q+ + EE+Q+ T E+DF+C G F N + E + E D +
Sbjct: 90 YFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKD 149
Query: 156 KAVEKTLQDMEKNP--------ELSKEREPE---PEPVEANSEESDSVFSENTEDLQEQF 204
+ D + P L +++ P PE + + SE D + E + EQ
Sbjct: 150 EKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKD--WEEVVVESMEQD 207
Query: 205 TTQKHHSHANSQANHAQ------GEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQ 258
+ H +S + + GEQA ++FE +++ P E++ S V +E
Sbjct: 208 RIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIE-----PVQESSFRSRKIAVEDEN 262
Query: 259 DKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKED 318
D +L E + + + S D++ +T + S + + T ++ G
Sbjct: 263 D---LEELNNGEPQTEHQQESESEIDSV---PKTQSELASESEHIPKPQSTGWFGGGFTS 316
Query: 319 EENQEDFDE-LPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDK 377
D D L L+ E+ P + +DKE + + I ND
Sbjct: 317 YLGFGDEDTGLELIA----EESNPPLQDFPNSISSDKEATVPCTE-ILTEKKDTITNDSL 371
Query: 378 NILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDD 416
++ +W D F+I+ D + L+ +EE+ D+
Sbjct: 372 SLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADE 410
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.4 bits (233), Expect = 1e-18
Identities = 226/1097 (20%), Positives = 452/1097 (41%), Gaps = 137/1097 (12%)
Query: 612 EHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQM 671
E +R+EL+E++V Q ++ DL +++ E NL +ER SK +
Sbjct: 871 EARRKELEEKMVSLLQ--------EKNDLQLQVQSET----ENLMDAEERCEGLIKSKIL 918
Query: 672 SE-KIR-LSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEE 729
E K++ L+E +E+ ++ E K + + D L+KVE++ + +E
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR-DIDDLELTLTKVEKEKHATEN 977
Query: 730 ----LLEDENAIN---AKRSKEKNPGNQGRQFDVN-LQVPDRAVLGTIHPDPEIEES--- 778
L E+ A+ +K +KEK + Q ++ LQV + V G I + ++E+
Sbjct: 978 KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 779 -----KQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDS 833
+QE + D E+ + + ++ + +K ++ FE S
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ-- 1095
Query: 834 IKIQTPELGEV-FQNKDSDY------LKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKY 886
KI ++ + FQ K + L+ + EH + + + +L++E E +E+
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ-RSDLARELEEISERL 1154
Query: 887 MGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQS---LQRFQKYF 943
E+ G+ +A+ E + + + ++ +++Q+ + ++
Sbjct: 1155 --EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212
Query: 944 NVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRD 1003
N+ ++ L++ S+LK + + + N+E L K E ++ ++ + + + +
Sbjct: 1213 NLQRVKQKLEKEKSELKM-EIDDMASNIE-ALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270
Query: 1004 LGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEET--ATLVMAPPLEEGLGGAMEEMQPL 1061
+ + ++A + +L + V K S + + + LEE L MEE
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE-LKRQMEEETKA 1329
Query: 1062 -----HEDNFSREKTAELNVQVPEEPTHLD--QRVIGDTHASEVSQKPNTEKDLDPGPVT 1114
H SR L Q EE QR + ++ + E D
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 1115 TEDTPMDAI----DANKQPETAAEEPASVTPLENAIL-LIYSFMFYLTKSLVATLP-DDV 1168
E+ +A + ETA + AS+ + + + M L +S A D
Sbjct: 1390 LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK 1449
Query: 1169 QPGPDFYGLPWKPVF--ITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKE 1226
Q D WK A L A T L Y+ ++ ++L+T+ +E
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE----EVVDQLETLRRE 1505
Query: 1227 NTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNL 1286
N L +++S+ ++I E+ K++QE K ++ E + ++ +E + E + +K L
Sbjct: 1506 NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE--HEESKIL 1563
Query: 1287 RVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSEC 1346
RV LE + ++ ++ +I E + IE+LK N+ +E ++ +A++
Sbjct: 1564 RVQLELSQVKSELDRKVI-EKDEEIEQLK----RNSQRAAEALQSVLDAEI--------- 1609
Query: 1347 HRVQEENARLKKKKEQLQQEIE-DWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINAL 1405
R + + RLKKK E E+E + +++E K Q L+ + H DD + +
Sbjct: 1610 -RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN 1668
Query: 1406 TNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQ-MMDVS-RTQTA 1463
+ QL ++E + G +EL +V ++ E+ + +Q ++D S R Q
Sbjct: 1669 EDLKEQLAIVE--------RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL 1720
Query: 1464 IS----------VVEEDLKLLQLKLRASVSTKCNLEDQVKK-------LEDDRNSLQAAK 1506
S +E D+ Q ++ S+ N E++ KK + ++ Q
Sbjct: 1721 HSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1780
Query: 1507 AGLEDECKTLRQKV-EILNELYQQKEMAL---QKKLSQEEYERQEREHRLSAADEKAVSA 1562
A LE K L Q V ++ + L + +++AL +K++ + E +E E+ L ++ A
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEA 1840
Query: 1563 AEEVKTYKRRIEEME-----------------DELQKTERSFKNQIATHEKKAHENWLKA 1605
+ Y+R+++EM D+LQ +S+K Q E++A+ +
Sbjct: 1841 LKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRC 1900
Query: 1606 RAAERAIAEEKREAANL 1622
R + + EE E A++
Sbjct: 1901 RRVQHEL-EEAAERADI 1916
Score = 82.4 bits (202), Expect = 4e-15
Identities = 93/449 (20%), Positives = 200/449 (44%), Gaps = 50/449 (11%)
Query: 1222 TIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDD 1281
T+ K+ + L+ ++QK+ ES+ ++ +K++ LS E K ++ + + E L
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504
Query: 1282 TAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEK 1341
KNL+ + EQ I+E K++++ + + E S++Q+AL E + S E
Sbjct: 1505 ENKNLQEEISDLTEQ-------IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 1342 VKSECHRVQEENARLK----KKKEQLQQEIEDWSKLHAELSEQIKSF----EKSQKDLEV 1393
+S+ RVQ E +++K +K + +EIE + +E ++S +S+ D
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617
Query: 1394 ALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQI-- 1451
+ ++N + + N E++ + G D + + NE +K Q+
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677
Query: 1452 -------------KQMMDVSRTQTAISVVEEDL-------KLLQLKLRASVSTKCNLEDQ 1491
+ + + +T+ + E++L +LL + + ++TK LE
Sbjct: 1678 VERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD 1737
Query: 1492 VKKLEDD-RNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMA--LQKKLSQEEYERQER 1548
+ + + + NS+Q ++ E K + + EL ++++ + L++ E ++
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Query: 1549 EHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAA 1608
+HRL A++ A +K K++I+++E+ + R +N++ +K+ E A
Sbjct: 1798 QHRLDEAEQLA------LKGGKKQIQKLENRV----RELENELDVEQKRGAEALKGAHKY 1847
Query: 1609 ERAIAEEKREAANLRHKLLELTQKMAMLQ 1637
ER + E +A +L L + LQ
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQ 1876
Score = 77.8 bits (190), Expect = 9e-14
Identities = 98/466 (21%), Positives = 196/466 (42%), Gaps = 53/466 (11%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKES-KKHVQETRKQNMILSDE---AIKYKDKI 1269
++ KL+ +K + E + L N +Q+I+E KK E + + DE +++++ KI
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112
Query: 1270 KTLEKNQEILDDTAK---NLRVMLESEREQNVKNQDLISENKKSIEKLKDV-ISMNA--- 1322
K L+ E L++ + LR +E +R + + ISE + I MN
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE 1172
Query: 1323 SEFSEVQIALNEAKLSEEKVKSECHRVQEENA---------------RLKKKKEQLQQEI 1367
+EF +++ L EA L E + + Q ++ +L+K+K +L+ EI
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Query: 1368 EDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKG 1427
+D + LS+ + E++ + +E + T I LN+ ++ Q +
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM----QKARLQTQN 1288
Query: 1428 GNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN 1487
G S + E + K K + Q ++ + Q +EE+ K A S++ +
Sbjct: 1289 GELSHRVEEKESLISQLTKSKQALTQQLEELKRQ-----MEEETKAKNAMAHALQSSRHD 1343
Query: 1488 LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
+ ++ E++ Q AKA L+ +V Y+ + ++L + + + +
Sbjct: 1344 CDLLREQYEEE----QEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIE-EMED-------------ELQKTERSFKNQIAT 1593
R E A S ++ K+R++ E+ED L K +R+F +A
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459
Query: 1594 HEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
++K E+ + AA++ E +R+ E+ ++ L+ E
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE 1505
Score = 74.3 bits (181), Expect = 1e-12
Identities = 90/461 (19%), Positives = 209/461 (45%), Gaps = 55/461 (11%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++++E+L+ + N+ELV K N E K K+ + + + E ++K+K L
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 1274 KNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNA---SEFSEVQI 1330
+ L++ N+ + + ++ +Q + + + +K+ +I +NA + +++
Sbjct: 984 EEMTALEE---NISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG 1040
Query: 1331 ALNEAK-------LSEEKVKSECHRVQEENARLKKKKEQLQQEIE----DWSKLHAEL-S 1378
+L + K ++ K++ + QE L+ K+Q++++++ + S+L A++
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100
Query: 1379 EQIKS--FEKSQKDLEVALTHKDDNINALTNCITQLN------LLECESESEG-QNKGGN 1429
EQ+ S F+K K+L+ + ++ I A ++ E E SE + G
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160
Query: 1430 DSDELANGEVGGDRNEKMKNQIKQ-------MMDVSRTQTAISVVE--EDLKLLQLKLRA 1480
S ++ + +KM+ +++ R + A SV E E + LQ +
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 1481 SVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTL-----------RQKVEILNELYQQ 1529
K L+ ++ + + +L +K+ +E C+T+ Q+ +++++L Q
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 1530 KEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKN 1589
K LQ + + + +E+E +S + + ++++ KR++E E+ K +
Sbjct: 1281 K-ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME--EETKAKNAMAHAL 1337
Query: 1590 QIATHE----KKAHENWLKARA-AERAIAEEKREAANLRHK 1625
Q + H+ ++ +E +A+A +RA+++ E A R K
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Score = 72.8 bits (177), Expect = 3e-12
Identities = 99/433 (22%), Positives = 193/433 (44%), Gaps = 78/433 (18%)
Query: 1217 SEKLKTIMKENTELV-QKLSNYEQKIKE-SKKHVQETRKQNMIL------SDEAIKYKDK 1268
+EK MKE+ E ++L+ E + KE +K V +++N + ++ + +++
Sbjct: 849 AEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
Query: 1269 IKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEV 1328
+ L K++ +L+ K L LE E E N +L+++ + +K S +
Sbjct: 909 CEGLIKSKILLEAKVKELTERLEEEEEMN---SELVAKKRNLEDKC-----------SSL 954
Query: 1329 QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ 1388
+ +++ +L+ KV+ E H + + L ++ L++ I SKL E ++ +++
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI---SKLTKEKKSLQEAHQQTL 1011
Query: 1389 KDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMK 1448
DL+V ++D +N L +L +D+L ++
Sbjct: 1012 DDLQV----EEDKVNGLIKINAKLE---------------QQTDDLEGS---------LE 1043
Query: 1449 NQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAG 1508
+ K D+ R + + E DLK+ Q + + K +E+++KK E + + LQA
Sbjct: 1044 QEKKLRADLERAKRKL---EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK--- 1097
Query: 1509 LEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKT 1568
++DE ++ + +Q+K LQ ++ + E E E EH L A EK S
Sbjct: 1098 IDDE--------QVHSLQFQKKIKELQARIEELE-EEIEAEHTLRAKIEKQRS------D 1142
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK--- 1625
R +EE+ + L++ + QI ++K+ E R E A + + AA LR K
Sbjct: 1143 LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Query: 1626 -LLELTQKMAMLQ 1637
+ EL +++ LQ
Sbjct: 1203 SVAELGEQIDNLQ 1215
Score = 68.9 bits (167), Expect = 4e-11
Identities = 96/490 (19%), Positives = 204/490 (41%), Gaps = 65/490 (13%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKD- 1267
Y+ ++ +E + + K N+E+ Q + YE + + ++E +K+ EA + +
Sbjct: 1351 YEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Query: 1268 ---KIKTLEKNQEILDDTAKNLRVMLESER------EQNVKNQD-LISENKKSIEKLKDV 1317
K +LEK ++ L ++L LE ++ +N D +++E K+ +++ +
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE 1470
Query: 1318 ISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAEL 1377
+ E + L + + + E+V + ++ EN L+++ L ++I + K E
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA 1530
Query: 1378 SEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANG 1437
+ K E+ + DL+VAL + ++ + I ++ L + +SE K +E+
Sbjct: 1531 EKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQL 1590
Query: 1438 EVGGDR----------------------NEKMKNQIKQM--------MDVSRTQTAISVV 1467
+ R +KM+ + +M ++ TQ + V
Sbjct: 1591 KRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTV 1650
Query: 1468 EEDLKLLQLKLRASVSTKCNLEDQVKKLEDDR----NSLQAAKAGLEDECKTLR------ 1517
+ LK QL L ++ + +L++Q+ +E L+ K LE +T R
Sbjct: 1651 QGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQEL 1710
Query: 1518 ----QKVEILNE-----LYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKT 1568
+V++L+ + +K++ Q E E +E R A+EKA A +
Sbjct: 1711 LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR--NAEEKAKKAITDAAM 1768
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
+++ +D ER KN T + H A + A+ K++ L +++ E
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHR---LDEAEQLALKGGKKQIQKLENRVRE 1825
Query: 1629 LTQKMAMLQE 1638
L ++ + Q+
Sbjct: 1826 LENELDVEQK 1835
Score = 65.5 bits (158), Expect = 5e-10
Identities = 100/474 (21%), Positives = 192/474 (40%), Gaps = 59/474 (12%)
Query: 1210 QVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKI 1269
Q+ Q +E L + L++ E K+KE + ++E + N L + +DK
Sbjct: 892 QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKC 951
Query: 1270 KTLEKNQEILDDTAKNLRVMLESER---EQNVKNQDLISENKKSIEKLKDVISMNASEFS 1326
+L+++ +DD L +E E+ E VKN +SE ++E+ ++
Sbjct: 952 SSLKRD---IDDLELTL-TKVEKEKHATENKVKN---LSEEMTALEENISKLTKEKKSLQ 1004
Query: 1327 EV-QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAEL-------- 1377
E Q L++ ++ E+KV + + NA+L+++ + L+ +E KL A+L
Sbjct: 1005 EAHQQTLDDLQVEEDKVNG----LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 1378 ------SEQIKSFEKSQKDLEVALTHKDDNINALTNCI----------------TQLNLL 1415
E I E ++ +E L K+ ++ L I Q +
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 1416 ECESESEGQN----KGGNDSDELANG-EVGGDRNEKMKNQIKQMMDVSRTQTA-ISVVEE 1469
E E E E ++ K +LA E +R E+ +++++ + A +
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR 1180
Query: 1470 DLKLLQLKLRASVST-KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQ 1528
DL+ L+ A+ +T + D V +L + ++LQ K LE E L+ +++ + +
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240
Query: 1529 QKEMALQKKLSQEEYERQEREHRLS---AADEKAVSAAEEVKTYKRRIEEMEDELQKTER 1585
AL K S E + E + S A DE+ ++ K R++ EL
Sbjct: 1241 ----ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 1586 SFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
++ I+ K + +R + EE + + H L +L+E+
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Score = 45.8 bits (107), Expect = 4e-04
Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 22/189 (11%)
Query: 1450 QIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGL 1509
+IK ++ + + ++ ++ED + + +L S + + LE+++ L ++N LQ +
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ---V 895
Query: 1510 EDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTY 1569
+ E + L E L + K + L+ K+ + +E E S K + ++ +
Sbjct: 896 QSETENLMDAEERCEGLIKSK-ILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 1570 KRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLEL 1629
KR I+++E L K E+ EK A EN +K + E EE + +L
Sbjct: 955 KRDIDDLELTLTKVEK---------EKHATENKVKNLSEEMTALEE---------NISKL 996
Query: 1630 TQKMAMLQE 1638
T++ LQE
Sbjct: 997 TKEKKSLQE 1005
Score = 35.8 bits (81), Expect = 0.41
Identities = 180/1064 (16%), Positives = 409/1064 (38%), Gaps = 164/1064 (15%)
Query: 410 EEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGR 469
EE+E+ + LV + + + ++ D D+++ L V+ K + +V ++ +
Sbjct: 931 EEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVK---NLSEEMT 987
Query: 470 GVQESKRGLVQDKTELEDENQE-------------GMTVHSSVHSNNLNSMPAAEKGKDT 516
++E+ L ++K L++ +Q+ G+ ++ + + + + +
Sbjct: 988 ALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKK 1047
Query: 517 LKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQES 576
L++ + + L+G + ++ E +QI E + E +++D ++
Sbjct: 1048 LRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQ 1107
Query: 577 LGSAPLMGDDHPNASRDSVEGDALVNGAKLHTL--SVEHQREELKEEL--VLKTQNQPRF 632
+ +E + HTL +E QR +L EL + + +
Sbjct: 1108 FQKKIKELQARIEELEEEIEAE--------HTLRAKIEKQRSDLARELEEISERLEEASG 1159
Query: 633 SSPDEIDLPRELEDEVPILGRNLPWQ--QERDVAATASKQMSEKI-----------RLSE 679
++ +I++ ++ E E + R+L Q AAT K+ ++ + R+ +
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 680 GEAKEDS-----LDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEELLEDE 734
KE S +D+ + +A+ ++ ++T T F S+++ D +L+ D
Sbjct: 1220 KLEKEKSELKMEIDDMASNIEALSKSK-SNIERTCRTVEDQF-SEIKAKDEQQTQLIHDL 1277
Query: 735 NAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQE-TSMILDSEKTSE 793
N A+ + +++ +V ++ L + ++ +SKQ T + + ++ E
Sbjct: 1278 NMQKARLQTQNG--------ELSHRVEEKESLIS-----QLTKSKQALTQQLEELKRQME 1324
Query: 794 TAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYL 853
K N + L ++ + +++ ++ E+ + ++D +
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI 1384
Query: 854 KNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVE 913
+ E K + + +E ENTE T + A+ E VE
Sbjct: 1385 QRTEELEEAK------KKLAQRLQEAEENTE----TANSKCASLEKTKQRLQG----EVE 1430
Query: 914 PGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEK 973
D ++ K+Q++ + + E + L E ++L++AQ+ES + E
Sbjct: 1431 DLMRDLERSHTACATLDKKQRNFDKV-----LAEWKQKLDESQAELEAAQKESRSLSTE- 1484
Query: 974 VLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHS 1033
L K+ A E + L+T EN++L +++ E+ A + ++L + K
Sbjct: 1485 -LFKMRNAYEEVV-----DQLETLRRENKNLQEEISDLTEQIA--ETGKNLQEAEKTKKL 1536
Query: 1034 TAEETATLVMAPPLEEGLGGAM-EEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGD 1092
+E + L +A LEE G EE + L + +EL+ +V E+ ++Q
Sbjct: 1537 VEQEKSDLQVA--LEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 1093 THASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSF 1152
A+E Q + M+ D N+ + + + +
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEG-DLNEMEIQLGHSNRQMAETQKHLRTVQGQ 1653
Query: 1153 MFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVT 1212
+ K L D ++ D L + + G+ + + L +R +++
Sbjct: 1654 L----KDSQLHLDDALRSNED---LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 1213 EQQI---SEKLKTIMKENTELV-----------QKLSNYEQKIKESKKHVQETRK---QN 1255
EQ++ S++++ + +NT L+ Q + E I+ES+ ++ +K
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766
Query: 1256 MILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESERE----------QNVKNQDLIS 1305
++++E K +D LE+ ++ L+ T K+L+ L+ + Q ++N+
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826
Query: 1306 ENK---------------------------------KSIEKLKDVISMNASEFSEVQIAL 1332
EN+ K+I +L+D++ ++ +
Sbjct: 1827 ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQA 1886
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAE 1376
EA+ S C RVQ E ++ + + ++ +KL A+
Sbjct: 1887 EEAEEQANTQLSRCRRVQHELEEAAERADIAESQV---NKLRAK 1927
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/390 (26%), Positives = 159/390 (40%), Gaps = 58/390 (14%)
Query: 1493 KKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER-EHR 1551
K +E+ + + K G + + K ++EI + Q + +K + E +++ +
Sbjct: 423 KLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSE 482
Query: 1552 LSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERA 1611
L+A E V + +++++++++ E + S K QIAT ++ E
Sbjct: 483 LTARHELQVEMKKMESDFEQKLQDLQGE-KDALHSEKQQIATEKQDL----------EAE 531
Query: 1612 IAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPL-SQNGSFGPS 1670
+++ E A L +L + ++MA L + V P P+ P PL +G+ P
Sbjct: 532 VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPP--SVPSRAPVPPAPPLPGDSGTIIPP 589
Query: 1671 PVSGGECS---PPLTVEPPVRPLSATLNRRDMPRSEFGSV---------DGPLPHPRWSA 1718
P + G+ + PP PP PL + P G+ D +P P
Sbjct: 590 PPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLP 649
Query: 1719 EASGKPSPSDPGSGTATMMNSSSRGSSPTRVLDEGKVNMAPKGPPPFPG---VPLMSTPM 1775
E G PSPS GTA GS+ P PPP PG +P P+
Sbjct: 650 EGVGIPSPSSLPGGTAIPPPPPLPGSA-----------RIPPPPPPLPGSAGIPPPPPPL 698
Query: 1776 GGP--VPPPIRYGPPPQLCGPFGPRPLPPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPR 1833
G +PPP PPP GP P P P P GPG+ PP PPG P P
Sbjct: 699 PGEAGMPPP----PPPLPGGPGIPPPPPFPGGPGIPPP----------PPGMGMPPPPPF 744
Query: 1834 GFLPGHAPFRPLGSLGPREYFIPGTRLPPP 1863
GF AP P G L P++ + P +L P
Sbjct: 745 GFGVPAAPVLPFG-LTPKKLYKPEVQLRRP 773
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 90.9 bits (224), Expect = 1e-17
Identities = 103/390 (26%), Positives = 159/390 (40%), Gaps = 58/390 (14%)
Query: 1493 KKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER-EHR 1551
K +E+ + + K G + + K ++EI + Q + +K + E +++ +
Sbjct: 432 KLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSE 491
Query: 1552 LSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERA 1611
L+A E V + +++++++++ E + S K QIAT ++ E
Sbjct: 492 LTARHELQVEMKKMESDFEQKLQDLQGE-KDALHSEKQQIATEKQDL----------EAE 540
Query: 1612 IAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPL-SQNGSFGPS 1670
+++ E A L +L + ++MA L + V P P+ P PL +G+ P
Sbjct: 541 VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPP--SVPSRAPVPPAPPLPGDSGTIIPP 598
Query: 1671 PVSGGECS---PPLTVEPPVRPLSATLNRRDMPRSEFGSV---------DGPLPHPRWSA 1718
P + G+ + PP PP PL + P G+ D +P P
Sbjct: 599 PPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLP 658
Query: 1719 EASGKPSPSDPGSGTATMMNSSSRGSSPTRVLDEGKVNMAPKGPPPFPG---VPLMSTPM 1775
E G PSPS GTA GS+ P PPP PG +P P+
Sbjct: 659 EGVGIPSPSSLPGGTAIPPPPPLPGSA-----------RIPPPPPPLPGSAGIPPPPPPL 707
Query: 1776 GGP--VPPPIRYGPPPQLCGPFGPRPLPPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPR 1833
G +PPP PPP GP P P P P GPG+ PP PPG P P
Sbjct: 708 PGEAGMPPP----PPPLPGGPGIPPPPPFPGGPGIPPP----------PPGMGMPPPPPF 753
Query: 1834 GFLPGHAPFRPLGSLGPREYFIPGTRLPPP 1863
GF AP P G L P++ + P +L P
Sbjct: 754 GFGVPAAPVLPFG-LTPKKLYKPEVQLRRP 782
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 89.7 bits (221), Expect = 2e-17
Identities = 108/470 (22%), Positives = 208/470 (44%), Gaps = 67/470 (14%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++ ++L+T+ +EN L Q++++ ++I E+ K + E K + ++ D LE
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE---LEKADIQLALE 1546
Query: 1274 KNQEILD-DTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
+ + L+ + AK LR+ LE + ++ ++ I+E + IE+LK N E +
Sbjct: 1547 EAEAALEHEEAKILRIQLELTQVKSEIDRK-IAEKDEEIEQLK----RNYQRTVETMQSA 1601
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIE-DWSKLHAELSEQIKSFEKSQKDL 1391
+A++ R + E RLKKK E EIE S + + +E +K Q L
Sbjct: 1602 LDAEV----------RSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Query: 1392 EVALTHKDDNINALTNCITQL-------NLLECESES-EGQNKGGNDSDELANGEVGGDR 1443
+ H DD + + QL NLL+ E E + + +LA E+ D
Sbjct: 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELL-DS 1710
Query: 1444 NEKMK-----------NQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQV 1492
NE+++ + K D+ + Q+ + D + + K + +++ + +++
Sbjct: 1711 NERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 1770
Query: 1493 KKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRL 1552
KK +D L+ K LE K L+ + L+E Q +K++ + E +E E L
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHR---LDEAEQLALKGGKKQIQKLETRIRELEFEL 1827
Query: 1553 SAADEKAVSAAEEVKTYKRRIEEM-----------------EDELQKTERSFKNQIATHE 1595
+K + + ++ Y+RR++E+ D+LQ +S+K Q +
Sbjct: 1828 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAD 1887
Query: 1596 KKAHENWLKARAAERAI--AEEKREAA-----NLRHKLLELTQKMAMLQE 1638
++A+ + K R A+ + AEE+ + A LR K + T ++ E
Sbjct: 1888 EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
Score = 77.8 bits (190), Expect = 9e-14
Identities = 102/464 (21%), Positives = 210/464 (45%), Gaps = 51/464 (10%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRK---QNMILSDEAIKY 1265
Y+ ++ +E + + K N+E+ Q + YE + + ++E +K Q + S+E ++
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
Query: 1266 KD-KIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASE 1324
+ K +LEK ++ L ++L M++ ER ++ + + +++ +K+ E
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDL--MVDVERANSLAAA--LDKKQRNFDKVLAEWKTKCEE 1463
Query: 1325 F-SEVQIALNEAK-LSEE--KVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ 1380
+E++ +L E++ LS E K+K+ ++ +K++ + L+QEI D ++ AE +
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523
Query: 1381 IKSFEKSQKDLEV--------------ALTHKDDNINALTNCITQL------NLLECESE 1420
I EKS+K +E+ AL H++ I + +TQ+ + E + E
Sbjct: 1524 IHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEE 1583
Query: 1421 SEGQNKGGNDSDELANGEVGGD---RNEKMKNQIKQMMDVSRTQTAIS----VVEEDLKL 1473
E + + E + + RNE ++ + K D++ + +S E LK
Sbjct: 1584 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 1474 LQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMA 1533
L+ T+ +L+D ++ ED + L A +E L+ +VE L +Q E A
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQL----AIVERRANLLQAEVEELRATLEQTERA 1699
Query: 1534 LQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIAT 1593
+K QE + ER L + + ++++T + +++ E++ R +N
Sbjct: 1700 -RKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET---DLMQLQSEVEDASRDARNA--- 1752
Query: 1594 HEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQ 1637
E+KA + A + +E+ +A+L L Q + LQ
Sbjct: 1753 -EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1795
Score = 73.9 bits (180), Expect = 1e-12
Identities = 86/413 (20%), Positives = 176/413 (42%), Gaps = 57/413 (13%)
Query: 1240 KIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVK 1299
K E++K + +++ DE K + K K LE+ L +L++ +++E E +
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 1300 NQD----LISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEEN-- 1353
++ LI + K+K+V A + E+ L K K++ EC ++++
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTE-RAEDEEEINAELTAKK---RKLEDECSELKKDIDD 957
Query: 1354 -----ARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNC 1408
A+++K+K + ++++ ++ + L E I + +K L+ A D++ A +
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 1409 ITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVE 1468
+ LN + + E + + D ++ + K +D+ R + + E
Sbjct: 1018 VNSLNKTKSKLEQQVE-----------------DLESSLEQEKKLRVDLERNKRKL---E 1057
Query: 1469 EDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQ 1528
DLKL Q + + K L++++KK + + LQ+ +EDE Q
Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSK---VEDE---------------Q 1099
Query: 1529 QKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFK 1588
+ QKK+ + + +E E + A ++ Y R +EE+ + L++
Sbjct: 1100 TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 1589 NQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK----LLELTQKMAMLQ 1637
QI ++K+ E R E A + + A LR K + EL +++ LQ
Sbjct: 1160 TQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ 1212
Score = 68.9 bits (167), Expect = 4e-11
Identities = 89/458 (19%), Positives = 189/458 (41%), Gaps = 49/458 (10%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++++E+ + + N EL K E + E KK + + + E ++K+K L
Sbjct: 921 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 980
Query: 1274 KNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALN 1333
+ LD+T L ++ +E + + D + + + L S + +++ +L
Sbjct: 981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 1040
Query: 1334 EAK-------LSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIK---- 1382
+ K ++ K++ + QE L+ K+QL + ++ + +L +++
Sbjct: 1041 QEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQT 1100
Query: 1383 ---SFEKSQKDLEVALTHKDDNINA--LTNCITQLNLLECESESEG-----QNKGGNDSD 1432
F+K K+L+ + ++ I A T T+ + E E + GG S
Sbjct: 1101 LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 1160
Query: 1433 ELANGEVGGDRNEKMKNQIKQ-------MMDVSRTQTAISVVE--EDLKLLQLKLRASVS 1483
++ + K++ +++ M+ R + A SV E E + LQ +
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 1484 TKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKV-----------EILNELYQQKEM 1532
K + ++ L S+ +KA LE C+TL ++ L+EL QK
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKS- 1279
Query: 1533 ALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIA 1592
LQ + + + +E+E +S + ++ + KR++E E+ K + Q +
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE--EENKAKNALAHALQSS 1337
Query: 1593 THE----KKAHENWLKARA-AERAIAEEKREAANLRHK 1625
H+ ++ +E + +A +RA+++ E A R K
Sbjct: 1338 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1375
Score = 64.7 bits (156), Expect = 8e-10
Identities = 106/514 (20%), Positives = 218/514 (42%), Gaps = 100/514 (19%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
Q +K+ ++ K ++L Q++ + E +++ KK + + L + ++ I LE
Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071
Query: 1274 KNQEILDDTAKN-------LRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFS 1326
+++ LD+ K L+ +E E+ ++ Q I E + IE+L++ I + +
Sbjct: 1072 NDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA 1131
Query: 1327 EVQIALNEAKLSEEKVKS---ECHRVQEENARLKKKKE----QLQQEIEDWSKLH----- 1374
+ + ++ E++ E V L KK+E +L++++E+ + H
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191
Query: 1375 ----------AELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQ 1424
AEL EQI + ++ ++ LE + I+ L++ + ++ + E +
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 1425 NKGGNDSDELANGEVGGDRNEKMKNQIKQMM-DVSRTQTAISVV----EEDLKLLQLKLR 1479
D+L+ +NE+++ + ++ SR QT + EE ++ R
Sbjct: 1252 TL----EDQLSEAR---GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304
Query: 1480 ASVSTKCNLEDQVKKLEDD---RNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQK 1536
+ + E+ ++LE++ +N+L A +C LR++ E E + + AL K
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 1537 KLSQ----------------EEYERQERE--HRLSAADE--KAVSA--AEEVKTYKRRIE 1574
S+ EE E +++ RL ++E +AV+A A KT +R
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 1575 EMED-------------ELQKTERSFKNQIATHEKKAHENWLKARAA---ERAIAEE--- 1615
E+ED L K +R+F +A + K E+ + A+ R+++ E
Sbjct: 1425 EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK 1484
Query: 1616 ---------------KREAANLRHKLLELTQKMA 1634
KRE NL ++ +LT+++A
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518
Score = 60.1 bits (144), Expect = 2e-08
Identities = 191/1019 (18%), Positives = 393/1019 (38%), Gaps = 160/1019 (15%)
Query: 525 ENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGNQMNDRK-IQQESLGSAPLM 583
+NDL+ S+ +L E+ +Q+++ + E+ K + D + I E +
Sbjct: 885 KNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKL 944
Query: 584 GDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEEL---------VLKTQNQPRFSS 634
D+ +D + + + + + E++ + L EEL + + + + +
Sbjct: 945 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Query: 635 PDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQMSEKIRLS--------EGE---AK 683
+D + ED+V L + +++ +S + +K+R+ EG+ A+
Sbjct: 1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ 1064
Query: 684 EDSLD--------EEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEELLEDEN 735
E LD +E K + ++ + + T G F K++E EEL E+
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 736 AINAKRSK-EKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSET 794
A A R+K EK + R+ + ++ +R +IE +K+ + L + E
Sbjct: 1125 AERATRAKTEKQRSDYARELE---ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE 1181
Query: 795 A---------------AKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSI----- 834
A A V G + + + ++ L +K++ E D S S+
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241
Query: 835 -KIQTPELGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPE------GELSK--EDHENTEK 885
K ++ +++ S+ + N E S L + GELS+ E+ E+
Sbjct: 1242 SKANLEKICRTLEDQLSE-ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 886 YMGTESQG--------SAAAEPEDDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQ 937
+ Q E E+ + + H S + + L+ + +EQ+
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHAL----QSSRHDCDLLREQYEEEQEGKA 1356
Query: 938 RFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFRASESQILSI------AE 991
Q+ + E + + Q+ +K L + + SE Q+ ++ E
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 992 KMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLI--YFVRYKHSTAEETATLVMAPPLEE 1049
K E DL ++ AA LD Q +K E A L +
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 1050 GLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEKDLD 1109
L + +++ +E+ + +T V E +L+Q + T ++++ T +L+
Sbjct: 1477 SLSTELFKLKNAYEEALDQLET------VKRENKNLEQEIADLT--EQIAENGKTIHELE 1528
Query: 1110 PGPVTTEDTPMDAIDANKQPETAAE-EPASVTPLENAILLIYSFMFYLTKSLVATLPDDV 1168
E D A ++ E A E E A + ++ + + S + +A +++
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI----DRKIAEKDEEI 1584
Query: 1169 QPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRV-YQVTEQQISEKLKTIMK-E 1226
+ Y RTV ++ + +V + + +LK M+ +
Sbjct: 1585 EQLKRNY----------------------QRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
Query: 1227 NTELVQKLSNYEQKIKESKKH---VQETRKQNMILSDEAIK----YKDKIKTLEKNQEIL 1279
E+ +LS+ ++ E+ KH VQ K + D+A++ K+++ +E+ +L
Sbjct: 1623 LNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLL 1682
Query: 1280 DDTAKNLRVMLE-SEREQNVKNQDLISENKK---------SIEKLKDVISMNASEF-SEV 1328
+ LR LE +ER + + Q+L+ N++ S+ K + + + SEV
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742
Query: 1329 QIALNEAKLSEEKVK----------SECHRVQEENARLKKKKEQLQQEIEDWSKLHAELS 1378
+ A +A+ +EEK K E + Q+ +A L++ K+ L+Q ++D E
Sbjct: 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 1379 E--------QIKSFEKSQKDLEVALTHKD----DNINALTNCITQLNLLECESESEGQN 1425
+ QI+ E ++LE L + +++ L ++ L +SE + +N
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Score = 34.7 bits (78), Expect = 0.92
Identities = 34/165 (20%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 1476 LKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQ 1535
LK + ++++ +K +D+ +A + LE++ TL Q ++ ++ LQ
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQ---------EKNDLQLQ 891
Query: 1536 KKLSQEEY-ERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATH 1594
+ E + +ER +L A + + +EV EE+ EL +R +++ +
Sbjct: 892 VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Query: 1595 EKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
+K + L E+ + + NL +L L + +A L E
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 996
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 89.4 bits (220), Expect = 3e-17
Identities = 222/1117 (19%), Positives = 445/1117 (39%), Gaps = 156/1117 (13%)
Query: 612 EHQREELKEELV--LKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASK 669
E +R+EL+E++V LK +N + E D + E+ L +N + + T
Sbjct: 870 EAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERA 929
Query: 670 QMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEE 729
+ E+I +E AK+ L++E K D + T L+KVE++ + +E
Sbjct: 930 EEEEEIN-AELTAKKRKLEDECSELKK-------DIDDLELT-----LAKVEKEKHATEN 976
Query: 730 ----LLEDENAIN---AKRSKEKNPGNQGRQFDVN-LQVPDRAVLGTIHPDPEIEES--- 778
L E+ ++ AK SKEK + Q ++ LQ + V ++E+
Sbjct: 977 KVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDD 1036
Query: 779 -----KQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDS 833
+QE + +D E+ + M ++ L +K ++ FE S+
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLIS- 1095
Query: 834 IKIQTPELGEVFQNKDSDYLK------NDNPEEHLKTSGLAGEPEGELSKEDHENTEKYM 887
KI+ + E+ K L+ + E + A + +LS+E E +E+
Sbjct: 1096 -KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL- 1153
Query: 888 GTESQGSAAAEPEDDSFHWTPHTSVEPGHSDK--REDLLIISSFFKEQQSLQRF-QKYFN 944
E+ G+ +A+ E + + + + + ++ + K S+ ++ N
Sbjct: 1154 -EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDN 1212
Query: 945 VHELEALLQEMSSKLKSAQQESLPYNMEKV------LDKVFRASESQILSIAEK------ 992
+ ++ L++ S+LK + + L N E + L+K+ R+ E Q+ + K
Sbjct: 1213 LQRVKQKLEKEKSELKM-ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQR 1271
Query: 993 ----MLDTRVAENRDLGMNENNIFEEAAVLDDIQ-----DLIYFVRYKHSTAEETATLVM 1043
+ R + G + E+ A++ + KH EET
Sbjct: 1272 LINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA--- 1328
Query: 1044 APPLEEGLGGAMEEMQPLHED-NFSREKTAELNVQVPEEPTHLDQ-RVIGDTHASEVSQK 1101
L L + + L E +E AEL + + + + Q R +T A + +++
Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1388
Query: 1102 PNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLV 1161
K + + ++A++A A + L+N + M + +S
Sbjct: 1389 LEEAKKKLAQRLQEAEEHVEAVNAK-----CASLEKTKQRLQNEV---EDLMLDVERSNA 1440
Query: 1162 ATLP-DDVQPGPDFYGLPWKPVF--ITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISE 1218
A D Q D WK + A L + T L VY+ + Q
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ--- 1497
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEI 1278
L+T+ +EN L Q++S+ ++I E K + E K + E + + ++ E + E
Sbjct: 1498 -LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE- 1555
Query: 1279 LDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLS 1338
+ K LR+ LE + ++ ++ I+E + I++LK N + E + +A++
Sbjct: 1556 -HEEGKILRIQLELNQVKSEVDRK-IAEKDEEIDQLK----RNHTRVVETMQSTLDAEI- 1608
Query: 1339 EEKVKSECHRVQEENARLKKKKEQLQQEIE-DWSKLHAELSEQIKSFEKSQKDLEVALTH 1397
R + + R+KKK E E+E + + +E ++++ +Q L+ H
Sbjct: 1609 ---------RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH 1659
Query: 1398 KDDNINALTNCITQL-------NLLECESE--------SEGQNKGGNDS--DELANGEVG 1440
DD + + QL NLL+ E E +E K D ++
Sbjct: 1660 LDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLL 1719
Query: 1441 GDRNEKMKNQIKQMM-DVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDR 1499
+N + N K++ DVS+ Q+ + V ++ + + K + +++ + +++KK +D
Sbjct: 1720 HTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1779
Query: 1500 NSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKA 1559
L+ K LE K L+ + L+E Q +K++ + E +E E + ++
Sbjct: 1780 AHLERMKKNLEQTVKDLQHR---LDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRN 1836
Query: 1560 VSAAEEVKTYKRRIEEME-----------------DELQKTERSFKNQIATHEKKAHENW 1602
A + ++ ++RR++E+ D+LQ +S+K Q E++++ N
Sbjct: 1837 AEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANL 1896
Query: 1603 LKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
K R L+H+L E ++ + + +
Sbjct: 1897 SKFR--------------KLQHELEEAEERADIAESQ 1919
Score = 73.9 bits (180), Expect = 1e-12
Identities = 88/419 (21%), Positives = 174/419 (41%), Gaps = 69/419 (16%)
Query: 1240 KIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVK 1299
K E++K + +++ DE K + K K LE+ L +L++ ++SE +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 1300 NQDLISE---NKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEEN--- 1353
++ + NK +E ++ A E E+ L K K++ EC ++++
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKK---RKLEDECSELKKDIDDL 960
Query: 1354 ----ARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVA-------LTHKDDNI 1402
A+++K+K + ++++ ++ A L E I K +K L+ L ++D +
Sbjct: 961 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV 1020
Query: 1403 NALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQT 1462
N LT T+L + D ++ + K MD+ R +
Sbjct: 1021 NILTKAKTKLE------------------------QQVDDLEGSLEQEKKLRMDLERAKR 1056
Query: 1463 AISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEI 1522
+ E DLKL Q + K L+++++K E + ++L + +EDE
Sbjct: 1057 KL---EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK---IEDE---------- 1100
Query: 1523 LNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
Q E+ LQKK+ + + +E + A A ++ R +EE+ + L++
Sbjct: 1101 -----QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 1583 TERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK----LLELTQKMAMLQ 1637
+ Q+ ++K+ E R E A + + A LR K + EL +++ LQ
Sbjct: 1156 AGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQ 1214
Score = 43.5 bits (101), Expect = 0.002
Identities = 44/194 (22%), Positives = 90/194 (46%), Gaps = 29/194 (14%)
Query: 1446 KMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAA 1505
K+ +IK ++ + T+ ++ ++E+ + + +L S + + LE+++ L ++N LQ
Sbjct: 834 KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 893
Query: 1506 KAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEE 1565
++ E +L E +L + K + L+ K+ +E ER E E ++A E
Sbjct: 894 ---VQSEADSLADAEERCEQLIKNK-IQLEAKI-KEVTERAEEEEEINA----------E 938
Query: 1566 VKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK 1625
+ KR++E+ EL+K + +A EK+ H K + NL +
Sbjct: 939 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK--------------NLTEE 984
Query: 1626 LLELTQKMAMLQEE 1639
+ L + +A L +E
Sbjct: 985 MAGLDETIAKLSKE 998
Score = 35.8 bits (81), Expect = 0.41
Identities = 102/524 (19%), Positives = 200/524 (38%), Gaps = 55/524 (10%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQAN 218
EK + M++ + +K+ + E EE + DLQ Q S A+S A+
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV-----QSEADSLAD 903
Query: 219 HAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTK 278
+ E E+++++K+++ T + + ++ A K ++ +LK
Sbjct: 904 -------AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956
Query: 279 FGSTADALVSDDETTRLVTSLEDDFDEE---LDTEYYAVGKE----DEENQEDFDELPLL 331
L ++ + + EE LD + KE E +Q+ D+L
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-- 1014
Query: 332 TFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIF--S 389
D ++ T AK+ +E+ D E + +E K+++ + + + ++ T+ +
Sbjct: 1015 AEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN 1074
Query: 390 IVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVD-DGLFIVD 448
+E + + E S+ + ED+ + K+ K A + ++ +
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134
Query: 449 IPKTNND-----KEVNAEHHIKGKGRGVQ---ESKRGLVQDKT--ELEDENQEGMTVHSS 498
K +D +E++ G Q KR K +LE+ + + ++
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194
Query: 499 VHSNNLNSMPAAEKGKDTLKSAYDDTE----------NDLKGAAIHISKGMLHEEKPGEQ 548
+ + +SM + D L+ E +DL A ISK + EK
Sbjct: 1195 LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRS 1254
Query: 549 ILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+ + SE ++ ++ +ND Q+ L + + SR E DALV+
Sbjct: 1255 LEDQVSELKTKEEEQQRLINDLTAQRARLQT------EAGEYSRQLDEKDALVSQLSRSK 1308
Query: 609 LSVEHQREELKEELVLKTQNQPRF-----SSPDEIDLPRELEDE 647
+ Q EELK +L +T+ + SS + DL RE +E
Sbjct: 1309 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE 1352
>gi|9910470 otoraplin precursor [Homo sapiens]
Length = 128
Score = 88.6 bits (218), Expect = 5e-17
Identities = 46/103 (44%), Positives = 60/103 (58%), Gaps = 9/103 (8%)
Query: 31 RFSEHKLCADDECSMLMYRGEALEDFTGPDCRFVNFKKGDPVYVYYKLAR--GWPEVWAG 88
R + KLCADDEC + A ED+ PDCRF+N KKG +YVY KL + G E WAG
Sbjct: 25 RLASKKLCADDECVYTISLASAQEDYNAPDCRFINVKKGQQIYVYSKLVKENGAGEFWAG 84
Query: 89 SV---GR----TFGYFPKDLIQVVHEYTKEELQVPTDETDFVC 124
SV G+ GYFP++L++ Y + +VPT + DF C
Sbjct: 85 SVYGDGQDEMGVVGYFPRNLVKEQRVYQEATKEVPTTDIDFFC 127
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 88.2 bits (217), Expect = 7e-17
Identities = 103/466 (22%), Positives = 209/466 (44%), Gaps = 70/466 (15%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDK 1268
Y+ ++ ++ K +TEL + + YE ES +H++ +++N L +E ++
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYE----ESLEHLETFKRENKNLQEEISDLTEQ 1515
Query: 1269 IKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEV 1328
+ + K L+ +R LE+E+ ++ Q + E + S+E + I EF+++
Sbjct: 1516 LGSSGKTIHELE----KVRKQLEAEK---MELQSALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 1329 QIALNEAKLSE-----EKVKSECHRV--------------QEENARLKKKKE----QLQQ 1365
+ + E KL+E E+ K RV + E R+KKK E +++
Sbjct: 1569 KAEI-ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI 1627
Query: 1366 EIEDWSKLHAELSEQIKSFEKSQKDLEV----ALTHKDDNINALTNCITQLNLLECESES 1421
++ +++ AE +Q+KS + KD ++ A+ DD + + NLL+ E E
Sbjct: 1628 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1687
Query: 1422 -EGQNKGGNDSDELANGEVGG---------DRNEKMKNQIKQM-MDVSRTQTAISVVEED 1470
+ S +LA E+ +N + NQ K+M D+S+ QT + ++
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1471 LKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQK 1530
+ + K + +++ + +++KK +D L+ K +E K L+ + L+E Q
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR---LDEAEQIA 1804
Query: 1531 EMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEME------------- 1577
+K+L + E +E E+ L A ++ + + ++ +RRI+E+
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 1578 ----DELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREA 1619
D+LQ +++K Q E++A+ N K R + + E + A
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Score = 77.4 bits (189), Expect = 1e-13
Identities = 102/466 (21%), Positives = 203/466 (43%), Gaps = 84/466 (18%)
Query: 1184 ITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKE 1243
I AF+G+ ++ W + + + E++ +++ ++ +E T L + L E + KE
Sbjct: 818 IRAFMGVKNWP---WMKLYFKIKPLLKSAERE--KEMASMKEEFTRLKEALEKSEARRKE 872
Query: 1244 -SKKHVQETRKQNMIL------SDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQ 1296
+K V +++N + D +++ L KN+ L+ K + LE E E
Sbjct: 873 LEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932
Query: 1297 NVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARL 1356
N + ++ K+ +E E SE++ +++ +L+ KV+ E H +
Sbjct: 933 NAE----LTAKKRKLE----------DECSELKRDIDDLELTLAKVEKEKHATEN----- 973
Query: 1357 KKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLE 1416
K + L +E+ ++ A+L+++ K+ +++ + L ++D +N LT +L
Sbjct: 974 --KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLE--- 1028
Query: 1417 CESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQL 1476
+ D ++ + K MD+ R + + E DLKL Q
Sbjct: 1029 ---------------------QQVDDLEGSLEQEKKVRMDLERAKRKL---EGDLKLTQE 1064
Query: 1477 KLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQK 1536
+ + K L++++KK + + N+L A +EDE Q LQK
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNAR---IEDE---------------QALGSQLQK 1106
Query: 1537 KLSQEEYERQEREHRLSAADEKAVSAAEEVKT-YKRRIEEMEDELQKTERSFKNQIATHE 1595
KL + + +E E L A + A + E++++ R +EE+ + L++ + QI ++
Sbjct: 1107 KLKELQARIEELEEELEA-ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1165
Query: 1596 KKAHENWLKARAAERAIAEEKREAANLRHK----LLELTQKMAMLQ 1637
K+ E R E A + + AA LR K + EL +++ LQ
Sbjct: 1166 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Score = 66.6 bits (161), Expect = 2e-10
Identities = 102/467 (21%), Positives = 186/467 (39%), Gaps = 52/467 (11%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
Q +K+ T+ K +L Q++ + E +++ KK + + L + ++ I LE
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE 1070
Query: 1274 KNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALN 1333
+++ LD+ K L + + Q L S+ +K +++L+ I E E A
Sbjct: 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE----ELEEELEAER 1126
Query: 1334 EAKLSEEKVKSECHRVQEE-NARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKS--QKD 1390
A+ EK++S+ R EE + RL++ +IE K AE + + E++ Q +
Sbjct: 1127 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186
Query: 1391 LEVALTHKD--DNINALTNCITQLNLLECESESEGQNKGGNDSDELANGE--VGGDRN-E 1445
A K D++ L I L ++ + E E D +N E + N E
Sbjct: 1187 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 1446 KMKNQIKQMMDVSRT---QTAISV--------------------VEEDLKLLQLKLRASV 1482
KM ++ M+ R+ +T SV ++E L+ R +
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL 1306
Query: 1483 STKCNLEDQVKKLEDD---RNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLS 1539
+ LED ++LE++ +N+L A +C LR++ E E + + L K S
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 1540 Q-----EEYERQ--EREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIA 1592
+ +YE +R L A +K +E + + L+KT+ +N+I
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI- 1425
Query: 1593 THEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
+ + + A A ++ N L E QK Q E
Sbjct: 1426 ------EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Score = 65.5 bits (158), Expect = 5e-10
Identities = 95/451 (21%), Positives = 199/451 (44%), Gaps = 51/451 (11%)
Query: 1215 QISEKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
+++ K + + E +EL + + + E + E +KH E + +N L++E + I L
Sbjct: 935 ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN--LTEEMAGLDEIIAKL 992
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
K ++ L + + L++E ++ + +++ K +E+ D + + + +V++ L
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDK----VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048
Query: 1333 NEAK--------LSEEKVKSECHRVQEENARLKKKKEQLQQ---EIEDWSKLHAELSEQI 1381
AK L++E + + Q+ + RLKKK +L IED L ++L +++
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108
Query: 1382 KSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGG 1441
K + ++LE L + + + L+ E + GG S ++ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Query: 1442 DRNEKMKNQIKQMM-------DVSRTQTAISVVE-----EDLKLLQLKLRASVST-KCNL 1488
+KM+ +++ R + A SV E ++L+ ++ KL S K L
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Query: 1489 EDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER 1548
+D +E + AKA LE C+TL ++ ++ + ++ SQ + E
Sbjct: 1229 DDVTSNMEQ----IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 1549 EHRLSAADEKAVSAAEEVK---TYKRRIEEMEDELQKTERSFKN------QIATHE---- 1595
DEK ++ + TY +++E+++ +L++ E KN Q A H+
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE-EVKAKNALAHALQSARHDCDLL 1343
Query: 1596 KKAHENWLKARA-AERAIAEEKREAANLRHK 1625
++ +E +A+A +R +++ E A R K
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Score = 64.3 bits (155), Expect = 1e-09
Identities = 121/538 (22%), Positives = 215/538 (39%), Gaps = 121/538 (22%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRK---QNMILSDEAIKY 1265
Y+ + +E + + K N+E+ Q + YE + + ++E +K Q + ++EA++
Sbjct: 1347 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 1266 KD-KIKTLEKNQEILDDTAKNLRVMLESER------EQNVKNQD-LISENKKSIEKLKDV 1317
+ K +LEK + L + ++L V +E ++ +N D +++E K+ E+ +
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ-- 1464
Query: 1318 ISMNASEFSEVQIALNEAK-LSEE--KVKSECHRVQEENARLKKKKEQLQQEIEDWSKLH 1374
SE++ + EA+ LS E K+K+ E K++ + LQ+EI D ++
Sbjct: 1465 --------SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 1375 AELSEQIKSFEKSQKDL--------------EVALTHKDDNINALTNCITQL------NL 1414
+ I EK +K L E +L H++ I Q+ L
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Query: 1415 LECESESEGQNKGG---NDSDELANGEVGGDRNE------KMKNQIKQM--------MDV 1457
E + E E + DS + + RNE KM+ + +M
Sbjct: 1577 AEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMA 1636
Query: 1458 SRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGL-------- 1509
+ Q + ++ LK Q++L +V +L++ + +E N LQA L
Sbjct: 1637 AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1696
Query: 1510 ------EDECKTLRQKVEILNELYQQKEMALQKK-----LSQEEYERQEREHRLSAADEK 1558
E E ++V++L+ Q + QKK LSQ + E +E A+EK
Sbjct: 1697 RSRKLAEQELIETSERVQLLHS--QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Query: 1559 AVSA-------AEE---------------------VKTYKRRIEEMED--------ELQK 1582
A A AEE +K + R++E E +LQK
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1814
Query: 1583 TE---RSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQ 1637
E R +N++ +K+ E+ R +ER I E + R LL L + LQ
Sbjct: 1815 LEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQ 1872
Score = 56.2 bits (134), Expect = 3e-07
Identities = 83/402 (20%), Positives = 160/402 (39%), Gaps = 60/402 (14%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
E + + I++ E Q + E+K+ E + +++ ++ ++ + D D +T
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA-ETR 1606
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
+N+ LRV + E + N L N+ + E K V S+ S + QI L
Sbjct: 1607 SRNEA--------LRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ-SLLKDTQIQL 1657
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHA-------ELSEQIKSFE 1385
++A + + +K V+ N L+ + E+L+ +E + E SE+++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH 1717
Query: 1386 KSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDS----DELANGEVGG 1441
L D +++ L + + + EC + E K D+ +EL +
Sbjct: 1718 SQNTSLINQKKKMDADLSQLQTEVEEA-VQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1776
Query: 1442 DRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNS 1501
E+MK ++Q + Q + E Q+ L+ LE +V++LE N
Sbjct: 1777 AHLERMKKNMEQT--IKDLQHRLDEAE------QIALKGGKKQLQKLEARVRELE---NE 1825
Query: 1502 LQAAKAGLEDECKTLRQKVEILNELYQQKE------MALQK-----KLSQEEYERQERE- 1549
L+A + + K +R+ + EL Q E + LQ +L + Y+RQ E
Sbjct: 1826 LEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEA 1885
Query: 1550 ---------------HRLSAADEKAVSAAEEVKTYKRRIEEM 1576
H L A+E+A A +V + + ++
Sbjct: 1886 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Score = 32.0 bits (71), Expect = 5.9
Identities = 34/127 (26%), Positives = 55/127 (43%), Gaps = 28/127 (22%)
Query: 1522 ILNELYQQKEMALQKKLSQEEYER-----QEREHRLSAADEKAVSAAEEVKTYKRRIEEM 1576
+L ++KEMA K EE+ R ++ E R +EK VS +E + +++
Sbjct: 839 LLKSAEREKEMASMK----EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 1577 EDEL----QKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQK 1632
+D L ++ ++ KN+I K N ER EE+ A ELT K
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMN-------ERLEDEEEMNA--------ELTAK 939
Query: 1633 MAMLQEE 1639
L++E
Sbjct: 940 KRKLEDE 946
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 86.7 bits (213), Expect = 2e-16
Identities = 105/495 (21%), Positives = 221/495 (44%), Gaps = 67/495 (13%)
Query: 1199 RTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMIL 1258
R L K Q +S L+ K+ + + ++ E +++++++ +QE +Q + L
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
Query: 1259 SDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVI 1318
S + +++ +L++ QE ++ KNL + + + Q + + ++ +IE L++
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 1319 SMNASEFSEVQIALNEAKLSEEKVKSECHRVQEE--------------NARLKKKKEQLQ 1364
+ + L E L+ +K++ +R+Q+E + L+KK+++
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 1365 QEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQ 1424
Q + + + A +E+ E ++ E AL+ LE + E E Q
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKET---------KALSLARALEEALEAKEEFERQ 1505
Query: 1425 NKG-GNDSDELANGEVGGDRN----EKMKNQIKQMMDVSRTQTAISVVEEDLKLLQ-LKL 1478
NK D ++L + + +N EK K ++Q ++ RTQ + +E++L+ + KL
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ--LEELEDELQATEDAKL 1563
Query: 1479 RASVSTKC------------NLEDQVKK-------------LEDDRNS---LQAAKAGLE 1510
R V+ + + +++ KK LED+R A+K +E
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 1511 DECKTLRQKVEILNELYQQKEMALQKKLSQ-EEYERQEREHRLSAADEKAVSAAEE--VK 1567
+ K L ++E N+ + L+K +Q ++Y+R+ E R S + A S E +K
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 1568 TYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKR----EAANLR 1623
+ + I ++++EL +ER+ ++ ++ A E + + + A+ +EKR A L
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADE-ITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 1624 HKLLELTQKMAMLQE 1638
+L E M +L +
Sbjct: 1743 EELEEEQSNMELLND 1757
Score = 83.2 bits (204), Expect = 2e-15
Identities = 103/464 (22%), Positives = 203/464 (43%), Gaps = 71/464 (15%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQK----IKESKKHVQETRKQNMILSDEAIKYKDKI 1269
++I L++ ++E E Q L N ++K I++ ++ + E L E + + KI
Sbjct: 921 EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980
Query: 1270 KTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
K +E+ +L+D +N + + E + ++ + + S+ + EK K++ + + EV
Sbjct: 981 KKMEEEILLLED--QNSKFIKEKKLMED-RIAECSSQLAEEEEKAKNLAKIRNKQ--EVM 1035
Query: 1330 IA-LNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE--- 1385
I+ L E EEK + E L+K K +L E D AEL QI +
Sbjct: 1036 ISDLEERLKKEEKTRQE----------LEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 1386 -KSQKDLEVALTHKDDNINALTNCITQLNLLEC---------ESESEGQNKGGNDSDELA 1435
K +++L+ AL DD N + + L+ ESE +NK +L+
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 1436 NGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN-------- 1487
+ E +K +++ +D + Q + E ++ +LK TK +
Sbjct: 1146 ------EELEALKTELEDTLDTTAAQQELRTKREQ-EVAELKKALEEETKNHEAQIQDMR 1198
Query: 1488 ---------LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKL 1538
L +Q+++ + + +L+ K GLE + K L +V++L ++ + E +KKL
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK-RKKL 1257
Query: 1539 SQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTER---SFKNQIATHE 1595
+ + QE ++S D V AE+ + ++ + L++ E+ F A+ E
Sbjct: 1258 ---DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 1596 KKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
+ + + + EE R+ NL ++ +L ++ LQE+
Sbjct: 1315 SQLQD-------TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351
Score = 75.1 bits (183), Expect = 6e-13
Identities = 92/436 (21%), Positives = 185/436 (42%), Gaps = 40/436 (9%)
Query: 1224 MKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTA 1283
+K EL +++ ++ + K + KQ LS+E K ++ ++ LD TA
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL------EDTLDTTA 1163
Query: 1284 KNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVK 1343
+ + E+E + L E K +++D+ +A+ E+ L +AK + ++
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 1344 SECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD---LEVALTHKDD 1400
++ +N L + + LQQ + +L Q++ + L V L K
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 1401 NI-NALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG-GDRNEKMKNQIKQMMDVS 1458
+ N L N T L E + KG + + A+ E D E ++ + +Q +++S
Sbjct: 1284 KLQNELDNVSTLL--------EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 1459 RTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQV-----------KKLEDDRNSLQAAKA 1507
+ I +EE+ LQ + + NLE QV KK++DD ++++
Sbjct: 1336 ---SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES--- 1389
Query: 1508 GLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVK 1567
LE+ K L + E L++ ++K +A KL + + Q+ L+ + A ++
Sbjct: 1390 -LEEAKKKLLKDAEALSQRLEEKALAYD-KLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 1568 TYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAE--EKREAANLRHK 1625
+++ +++ E + + + E +A E KA + RA+ E E +E ++K
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 1626 LLELTQKMAMLQEEPV 1641
L + M ++ V
Sbjct: 1508 QLRADMEDLMSSKDDV 1523
Score = 73.6 bits (179), Expect = 2e-12
Identities = 94/467 (20%), Positives = 216/467 (46%), Gaps = 53/467 (11%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQ-ETR-KQNMILS-----DEAIKY 1265
++Q++ L+ K+ +L+ + + + E + + E R K+ LS +EA++
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 1266 KDKI----KTLEKNQEIL----DDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDV 1317
K++ K L + E L DD KN+ + +S+R + + E + +E+L+D
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL----EQQVEEMRTQLEELED- 1553
Query: 1318 ISMNASEFSEVQIALNEAKLS---EEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLH 1374
+ A+E +++++ +N + E +++ + +E+ L K+ +L+ E+ED K
Sbjct: 1554 -ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 1375 AELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDEL 1434
A K E KDLE + + + + + +L + + E + + +
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 1435 ANGEVGGDRNEKMKNQIKQMMD-VSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVK 1493
A + + + ++ +I Q+ + ++ ++ A E++ L ++ S S K L D+ +
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732
Query: 1494 KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQ---------KEMALQKKLSQ---- 1540
+LE A A LE+E + + +E+LN+ +++ E+A ++ +Q
Sbjct: 1733 RLE-------ARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 1541 --EEYERQEREHRLSAAD-EKAVSA--AEEVKTYKRRIEEMEDELQK--TERSFKNQIAT 1593
++ ERQ +E + + E AV + + + +I ++E++L++ ER+ N++
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 1594 H-EKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
EKK E +++ R + K + ++ +L +++ +EE
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Score = 68.2 bits (165), Expect = 7e-11
Identities = 200/1061 (18%), Positives = 399/1061 (37%), Gaps = 158/1061 (14%)
Query: 605 KLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQER--D 662
+L ++ E + ++++EE++L +F ++ +ED + L ++E+ +
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-----MEDRIAECSSQLAEEEEKAKN 1024
Query: 663 VAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGG--------P 714
+A +KQ L E KE+ +E KA + + TD D
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQEL--EKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 715 AFLSKVEEDDYPS-----EELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTI 769
L+K EE+ + +E L NA+ R + F+ ++A
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 770 HPDPEIEESKQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSD 829
E+E K E E T +T A + + E ++ L ++ + D
Sbjct: 1143 DLSEELEALKTEL------EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 830 FSDSIKIQTPELGEVFQN---------KDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDH 880
EL E + K+ L+ DN E + L + K +
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL------QQVKAES 1250
Query: 881 ENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQ-RF 939
E+ K + + Q A E D + S + +L +S+ +E + +F
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLR----VELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 940 QK-----YFNVHELEALLQE-------MSSKLKSAQQESLPYNMEKVLDKVFRAS-ESQI 986
K + + + LLQE +SS+++ ++E ++ ++ R + E Q+
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 987 LSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIY-----------FVRYKHSTA 1035
L++ ++ DT+ + DLG E+ + +L D + L + K+
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 1036 EETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKT-----AELNVQVPEEPTHLDQRVI 1090
+E L + + + +E+ Q + + EK+ AE + E + + +
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 1091 GDTHASE--VSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILL 1148
A E + K E+ ED D K E S LE +
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK---NVHELEKSKRALEQQVEE 1543
Query: 1149 IYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRV 1208
+ + + L L AT +D + + K F +R
Sbjct: 1544 MRTQLEELEDELQAT--EDAKLRLEVNMQAMKAQF----------------------ERD 1579
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQK---IKESKKHVQETRKQNMILSDEAIKY 1265
Q ++Q EK + ++K+ EL +L + ++ SKK ++ K + A K
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 1266 KDK-IKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASE 1324
+D+ IK L K Q + D + L E ++ +++K+S +KLK + +E
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQREL-------EEARASRDEIFAQSKESEKKLKSL----EAE 1688
Query: 1325 FSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSF 1384
++Q L ++ + + E + +E K L +++ +L A +++ +
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSAL---LDEKRRLEARIAQLEEEL 1745
Query: 1385 EKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRN 1444
E+ Q ++E+ +D T + LN E +E K N +L +N
Sbjct: 1746 EEEQSNMELL----NDRFRKTTLQVDTLN-AELAAERSAAQKSDNARQQLER------QN 1794
Query: 1445 EKMKNQIKQM---------MDVSRTQTAISVVEEDLKLLQLKLRASVS-----TKCNLED 1490
+++K +++++ +S + I +EE L+ + K RA+ + T+ L++
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE-QEAKERAAANKLVRRTEKKLKE 1853
Query: 1491 QVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREH 1550
++ED+R K +E ++Q + +L + +E A + S+ + +R+
Sbjct: 1854 IFMQVEDERRHADQYKEQMEKANARMKQ---LKRQLEEAEEEATRANASRRKLQRE---- 1906
Query: 1551 RLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQI 1591
L A E + EV T K R+ + RS + Q+
Sbjct: 1907 -LDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQL 1946
Score = 55.8 bits (133), Expect = 4e-07
Identities = 69/310 (22%), Positives = 133/310 (42%), Gaps = 53/310 (17%)
Query: 1337 LSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALT 1396
L + + E EE ++K+K+ +++ E+E+ + H +L E+ K+ Q E L
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE-KNILAEQLQAETELF 903
Query: 1397 HKDDNINALTNCITQ-----LNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQI 1451
+ + + A Q L+ LE E E + RN+ ++N+
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEE------------------RNQILQNEK 945
Query: 1452 KQMMDVSRTQTAISVVEEDL--------KLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQ 1503
K+M Q I +EE L KL K+ A K +E+++ LED +
Sbjct: 946 KKM------QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-KMEEEILLLEDQNSKFI 998
Query: 1504 AAKAGLED---ECKTL----RQKVEILNELYQQKEMA---LQKKLSQEEYERQEREHRLS 1553
K +ED EC + +K + L ++ ++E+ L+++L +EE RQE E
Sbjct: 999 KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 1554 AADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIA 1613
D + +++ + +I+E++ +L K E + +A + + L A + +
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA----RGDDETLHKNNALKVVR 1114
Query: 1614 EEKREAANLR 1623
E + + A L+
Sbjct: 1115 ELQAQIAELQ 1124
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 85.9 bits (211), Expect = 3e-16
Identities = 116/524 (22%), Positives = 220/524 (41%), Gaps = 85/524 (16%)
Query: 1221 KTIMKENTELVQKL----SNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQ 1276
++ + E ++ + KL S ++ + E+ ++ K+ +L+D+ + +I+ L+K+
Sbjct: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934
Query: 1277 EILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEK-------LKDV-ISMNASEFSEV 1328
+L+D+ K L+++ E+ + + +IS NK+ IE+ LK++ S+N + + +
Sbjct: 935 HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
Query: 1329 QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ 1388
Q + + A +E+ KS + E + + K++K L Q E+ + +LS++ K+ ++
Sbjct: 995 QKSESFANYIDEREKS----ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 1389 KDLEVALTHKDDNINALTNCITQLN------------------------LLECESESEGQ 1424
LE L N + QL +LE E+ +
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQAL 1110
Query: 1425 NKGGNDSDELANGEVGGDRNE---------KMKNQI-------KQMMDVSRTQTAISVVE 1468
D+ + E GG + E KM+ ++ +Q+M V +T+ +E
Sbjct: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
Query: 1469 EDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQ 1528
+ +K R S +CN + Q+ LE SL + A L LR K L E +
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQM-DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229
Query: 1529 QKEMALQKKL----------SQEEYERQEREHRLSA---ADEKAVSAAEEVKTYKRRIEE 1575
+KE LQ +L + ++ + QE A+EK +S E+ T +
Sbjct: 1230 EKE-CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288
Query: 1576 MEDELQKTERSFKN-----QIATHEKKAHENWLKARAAERAIAEEK--REAANLRHKLLE 1628
++ LQ T +I EK L +E A K E L +++
Sbjct: 1289 LQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348
Query: 1629 LTQKMAMLQEEPVIVKPMPG-----KPNTQNPPRRGPLSQNGSF 1667
L +L E +V+ +PG +PN Q+P PL ++ S+
Sbjct: 1349 LNDDSGLLHGE--LVEDIPGGEFGEQPNEQHPVSLAPLDESNSY 1390
Score = 75.5 bits (184), Expect = 5e-13
Identities = 120/485 (24%), Positives = 215/485 (44%), Gaps = 102/485 (21%)
Query: 1224 MKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDT- 1282
+KE TEL+Q LS+ ++ + K H+QE K+++LEK+ + L T
Sbjct: 2009 VKEKTELLQTLSSDVSELLKDKTHLQE-----------------KLQSLEKDSQALSLTK 2051
Query: 1283 --AKNLRVMLESEREQNVKN----QDLISEN---KKSIEKLKDVISMNASEF----SEVQ 1329
+N L E+E VK Q +SE+ K ++ K + + EF S Q
Sbjct: 2052 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
Query: 1330 IALNEAKLSEEKV--------KSECHRVQE------ENARLKKKKEQLQQEIEDWSKLHA 1375
+++ + EK+ K + H ++ EN LK K E L++E++ S+ +
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ-MSEENQ 2170
Query: 1376 ELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEG-----QNKGGND 1430
EL I E S+ ++E T ++ +L + +L+L+ SE E Q K G
Sbjct: 2171 EL--VILDAENSKAEVETLKTQIEEMARSLK--VFELDLVTLRSEKENLTKQIQEKQGQL 2226
Query: 1431 SD---ELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRA------- 1480
S+ L++ + + E+ + QIK+ ++TA+ +++ LK L + A
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKE-----ESKTAVEMLQNQLKELNEAVAALCGDQEI 2281
Query: 1481 SVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQ 1540
+T+ +L+ +++ RNS++ +A LE + K + L L Q KE L +
Sbjct: 2282 MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK------KQLCVLQQLKESEHHADLLK 2335
Query: 1541 EEYERQEREHRLSAADE-----KAVSAAEEVKTYKRRIEEMEDELQKTE------RSFKN 1589
E ERE ++ ++ +A ++ EV+T K +IE M L+ E RS K
Sbjct: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKE 2395
Query: 1590 QIATHEKK-------------AHENWLKARAAERAIAEEKREAA--NLRHKLLELTQKMA 1634
+ +K + EN L+ + E+ +EK A L+ +L EL +++A
Sbjct: 2396 NLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVA 2455
Query: 1635 MLQEE 1639
L +
Sbjct: 2456 ALHND 2460
Score = 73.6 bits (179), Expect = 2e-12
Identities = 99/472 (20%), Positives = 202/472 (42%), Gaps = 73/472 (15%)
Query: 1216 ISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT---- 1271
+SEKL+ ++ EL+Q++ E + + H ++ +++ + D K D K
Sbjct: 1842 LSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLD 1899
Query: 1272 ---------------------LEKNQEILDDTAKNLRVMLESEREQNV-----KNQDLIS 1305
LE + E++ + L + ++E +Q V + +++
Sbjct: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQ--TEKLCLEKDNENKQKVIVCLEEELSVVT 1957
Query: 1306 ENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSEC-HRVQEENARLKKKKEQLQ 1364
+ + D +S + ++ + E E +SEC H +Q A +K+K E LQ
Sbjct: 1958 SERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQ 2017
Query: 1365 QEIEDWSKL---HAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESES 1421
D S+L L E+++S EK + L + ++ I L + LL ESES
Sbjct: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK---EKELLVKESES 2074
Query: 1422 EGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRAS 1481
+D ++L V + + + + +S TQ + + ++ L++++ A
Sbjct: 2075 LQARLSESDYEKL---NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Query: 1482 VSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQE 1541
+ ++ +++K+ E + +S L+D+ + L +++++ E Q+ + L + S+
Sbjct: 2132 EKKQLHIAEKLKERERENDS-------LKDKVENLERELQMSEE--NQELVILDAENSKA 2182
Query: 1542 EYER-----QEREHRLSAADEKAVSAAEEVKTYKRRIEEME---DELQKTERSFKNQIAT 1593
E E +E L + V+ E + ++I+E + EL K SFK+ +
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 1594 HEKKAHENWLKARAAERAIAEEKREAAN-LRHKLLELTQKMAMLQEEPVIVK 1644
E+ AE I EE + A L+++L EL + +A L + I+K
Sbjct: 2243 KEQ-----------AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Score = 72.4 bits (176), Expect = 4e-12
Identities = 87/406 (21%), Positives = 178/406 (43%), Gaps = 62/406 (15%)
Query: 1216 ISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
+S+ L+ + E E +LS+ ++++ + ++ +++ R + + + +K+K E+
Sbjct: 2089 VSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE 2148
Query: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLI---SENKKS-IEKLKDVISMNASEFSEVQIA 1331
+ L D +N LE E + + +NQ+L+ +EN K+ +E LK I A ++
Sbjct: 2149 NDSLKDKVEN----LERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD 2204
Query: 1332 LNEAKLSEEKVKSECHRVQEENARLKK----------KKEQLQQEIEDWSKLHAE-LSEQ 1380
L + +E + + Q + + L K +KEQ + +I++ SK E L Q
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264
Query: 1381 IKSFEKS----------QKDLEVALTHKDDNINALTNCITQLNL-LECESESE----GQN 1425
+K ++ K E +L + + L N I +L LE + + + Q
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
Query: 1426 KGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTK 1485
K +L G V +++ ++++RT + +E + ++K
Sbjct: 2325 KESEHHADLLKGRV---------ENLERELEIARTNQEHAALEAE------------NSK 2363
Query: 1486 CNLEDQVKKLEDDRNSLQAAKAGLEDECKTLR-QKVEILNELYQQKEMALQKKLSQEEYE 1544
+E K+E SL+ GLE + T+R +K + NEL +++E + ++ +E
Sbjct: 2364 GEVETLKAKIEGMTQSLR----GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
Query: 1545 R--QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFK 1588
QE+E EK+ +A E ++T + + E L + + K
Sbjct: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
Score = 72.0 bits (175), Expect = 5e-12
Identities = 188/877 (21%), Positives = 355/877 (40%), Gaps = 103/877 (11%)
Query: 804 REPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKNDNPEEHLK 863
+E +V++ L + ++ +E+ + S +++ E GE L + E H
Sbjct: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALR-----LSSTQEEVHQL 2117
Query: 864 TSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKREDL 923
G+ E + E EK ++ E E+DS DK E+L
Sbjct: 2118 RRGI------EKLRVRIEADEKKQLHIAEKLKERERENDSL------------KDKVENL 2159
Query: 924 LIISSFFKEQQSLQRFQKYFNVHELEAL---LQEMSSKLKSAQQESLPYNMEKV-LDKVF 979
+E Q L + E+E L ++EM+ LK + + + EK L K
Sbjct: 2160 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2219
Query: 980 RASESQILSIAEKMLDTRVAENRDLGMNENNIFEEA-AVLDDIQDLIYFVRYKHSTAEET 1038
+ + Q LS +K+L + + + E I EE+ ++ +Q+ + + A
Sbjct: 2220 QEKQGQ-LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK--ELNEAVAALC 2276
Query: 1039 ATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEV 1098
+ E+ L +EE L N + A L ++ L Q + HA +
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLR--NSIEKLRARLEADEKKQLCVLQQLKESEHHADLL 2334
Query: 1099 SQK-PNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTP----LENAILLIYSFM 1153
+ N E++L+ E ++A ++ + ET + +T LE ++ I S
Sbjct: 2335 KGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK 2394
Query: 1154 FYLTKSL------------VATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTV 1201
LT L + + +++ + + K TA + + L V
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERV 2454
Query: 1202 LVVKD--RVYQVTEQQISEKLKTIMKENTELVQKL----SNYEQKIKESKKHVQETR--K 1253
+ + + EQ +S +++ + E +L+Q L +NY +QE K
Sbjct: 2455 AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 1254 QNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEK 1313
Q + DE I ++K ++QE L + + +EQN++ ++L E ++ I+
Sbjct: 2515 QKLEKKDEEIS---RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2571
Query: 1314 LKDVISMNASEFSEVQIALNEAKLSE---EKVKSECHRVQEENARLKKKKEQLQQEIEDW 1370
L+ S NAS +++ + K E E K + E+ ++ K+ +LQ+E+ +
Sbjct: 2572 LQ---SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEM 2628
Query: 1371 SKLHAELSEQIKSFEKSQKDLEVALTHKD-----DNINALTNCITQLNL-LECESESEGQ 1424
++ AEL E++ S EK++ E+ L ++ D + LT ++L L+C + + +
Sbjct: 2629 AQKTAELQEEL-SGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVE 2687
Query: 1425 NKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVST 1484
K G +E+A ++ EK K+Q + + + I E L K S
Sbjct: 2688 -KEGKVREEIAEYQLRLHEAEK-KHQALLLDTNKQYEVEIQTYREKLTS---KEECLSSQ 2742
Query: 1485 KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMA----------- 1533
K ++ E+ NSL+A LE+ KT ++ +N+L ++ E A
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSC 2802
Query: 1534 ---------LQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTE 1584
LQK+LSQ + QE++ + D K E+K K +EE E +
Sbjct: 2803 KQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL 2861
Query: 1585 RSFKNQIATHEK--KAHENWLKARAAERAIAEEKREA 1619
+ + + +HEK KA E L+ + A + K+++
Sbjct: 2862 DKYCSLLISHEKLEKAKE-MLETQVAHLCSQQSKQDS 2897
Score = 65.5 bits (158), Expect = 5e-10
Identities = 96/473 (20%), Positives = 192/473 (40%), Gaps = 60/473 (12%)
Query: 1210 QVTEQQISEKLKTIMKENT--------------ELVQKLSNYEQKIKESKKHVQETRKQN 1255
Q+ E ++ ++ + KEN L +L N +Q + +S+ +E + +N
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530
Query: 1256 MILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLK 1315
++KI NQ+ T + L++ + +Q +QDL+ + + IE+L
Sbjct: 531 TSQETMLRDLQEKI-----NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 1316 DVISMNASEFSEVQIALNEAK-----LSEEKVKSECHRVQEEN--ARLKKKKEQLQQEIE 1368
D +S E + AL K L EEK C + + E +++ +KE LQ +I
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN 645
Query: 1369 DWS--------KLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESE 1420
K H E +E++++ E +++L V + + + +++ + + L E +
Sbjct: 646 HLETCLKTQQIKSH-EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 704
Query: 1421 SEGQNKGGNDSDELAN---------GEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDL 1471
+ + E+ N G+V D K++ ++MD R + E L
Sbjct: 705 QKAEFSDQKHQKEIENMCLKTSQLTGQV-EDLEHKLQLLSNEIMDKDRCYQDLHAEYESL 763
Query: 1472 KLLQLKLRASVSTKCNLEDQVKKL--EDDRNSLQAAKAGLEDECKTL---RQKVEILNEL 1526
+ L AS+ T ED + L D + ++ + A + E ++ R + + +
Sbjct: 764 RDLLKSKDASLVTN---EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 1527 YQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERS 1586
+ LQ ++ E+ + ++ S ++ EE+ K IEE L K E+
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ----CEELVQIKGEIEE---NLMKAEQM 873
Query: 1587 FKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
++ +A ++ + A + +AE N +L L K+ Q E
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
Score = 65.1 bits (157), Expect = 6e-10
Identities = 94/449 (20%), Positives = 188/449 (41%), Gaps = 49/449 (10%)
Query: 1210 QVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKI 1269
Q + Q+SE L ++ L+++ E +IKE K E +L ++ + + +
Sbjct: 2220 QEKQGQLSE-LDKLLSSFKSLLEEKEQAEIQIKEESKTAVE------MLQNQLKELNEAV 2272
Query: 1270 KTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
L +QEI+ T ++L +E E + + SIEKL+ + + + V
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQL-----------RNSIEKLRARLEADEKKQLCVL 2321
Query: 1330 IALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQK 1389
L E++ + +K ++ E + +E E E+ L +I+ +S +
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Query: 1390 DLEVALTHKDDNINALTN-------CITQLNLLECESESEGQNKGGNDSDELANGEVGGD 1442
LE+ + LTN I++L ++ E+ Q K + +++ E
Sbjct: 2382 GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEK---EQEKVQMKEKSST 2438
Query: 1443 RNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVS----TKCNLEDQVKKLEDD 1498
E ++ Q+K++ + A+ +E K + L + V K L + + +++
Sbjct: 2439 AMEMLQTQLKEL---NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 1499 RNSLQAAKAGLEDECKTLRQKVE--------ILNELYQQKEMALQKKLSQEEYERQEREH 1550
LQ++ GL E + +QK+E + N++ Q++ L KLSQ E E Q +
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ--LVSKLSQVEGEHQLWKE 2553
Query: 1551 RLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAER 1610
+ V ++++ + + ++D L+ + S+KN E + +
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 1611 AIAEEKREAANLRHKLLELTQKMAMLQEE 1639
A+E L+ ++ E+ QK A LQEE
Sbjct: 2614 MTAKE----TELQREMHEMAQKTAELQEE 2638
Score = 63.2 bits (152), Expect = 2e-09
Identities = 99/440 (22%), Positives = 190/440 (43%), Gaps = 65/440 (14%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQE--TRKQN--MILSDEAIK 1264
Y EQ++ + + + + + EQKIKE +K QE +R+Q L E I+
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ 416
Query: 1265 YKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASE 1324
K ++ QE+ AKN+ +L++E ++ + + N +E+ K +
Sbjct: 417 MKARL-----TQEL--QQAKNMHNVLQAELDKLTSVKQQLENN---LEEFKQKLCRAEQA 466
Query: 1325 FSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKL---HAELSEQI 1381
F QI NE + S E++K E + ++ + + ++ L+ E+++ + +E++
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 1382 KSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGG 1441
K+ SQ E L + IN N +T L ++ E Q +
Sbjct: 527 KAKNTSQ---ETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR------------DCSQ 571
Query: 1442 DRNEKMKNQIKQMMD-VSRTQ-------TAISVVEEDLKLLQLKLRASVSTKCNLEDQVK 1493
D +K ++ I+Q+ D +S+T+ +A+ + +++ + L+ + K E +
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631
Query: 1494 KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLS 1553
++E ++ +LQ+ LE KT + K NE + EM E E + +
Sbjct: 632 QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM-------DRENLSVEIRNLHN 684
Query: 1554 AADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIA 1613
D K+V EV+T K E++ QK E F +Q H+K+ LK +
Sbjct: 685 VLDSKSV----EVETQKLAYMELQ---QKAE--FSDQ--KHQKEIENMCLKT-------S 726
Query: 1614 EEKREAANLRHKLLELTQKM 1633
+ + +L HKL L+ ++
Sbjct: 727 QLTGQVEDLEHKLQLLSNEI 746
Score = 59.3 bits (142), Expect = 3e-08
Identities = 101/433 (23%), Positives = 184/433 (42%), Gaps = 103/433 (23%)
Query: 1285 NLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKS 1344
NL++ ++ +N++ +I + + +E L +N + + ++ L E +L K+++
Sbjct: 1771 NLQLRVKETSNENLRLLHVIEDRDRKVESL-----LNEMKELDSKLHLQEVQLMT-KIEA 1824
Query: 1345 ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKD----- 1399
C +++ LKK+ L +++E +S H EL +++++ E DLE+ H D
Sbjct: 1825 -CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM---HADKSSRE 1880
Query: 1400 ---DNINALTNCITQLNLLECESESE--GQNKGGNDSDEL---ANGEV--------GGDR 1443
DN+ A N + L+ E+E K + + L A+ EV D
Sbjct: 1881 DIGDNV-AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 1444 NEKMK----------------NQIKQMMD-VSRTQTAISVVEEDLK-------------- 1472
K K NQ++ +D +S+ TA+ + E +K
Sbjct: 1940 ENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL 1999
Query: 1473 ---------------LLQLKLRASVS----TKCNLEDQVKKLEDDRNSLQAAKAGLEDEC 1513
LLQ L + VS K +L+++++ LE D +L K LE++
Sbjct: 2000 HCIQVAEAEVKEKTELLQ-TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQI 2058
Query: 1514 KTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAA----DEKAV---SAAEEV 1566
L ++ E+L ++ +LQ +LS+ +YE+ L AA E A+ S EEV
Sbjct: 2059 AQLNKEKELL----VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEV 2114
Query: 1567 KTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKL 1626
+R IE++ ++ E K Q+ EK LK R E ++K E ++
Sbjct: 2115 HQLRRGIEKLRVRIEADE---KKQLHIAEK------LKERERENDSLKDKVENLERELQM 2165
Query: 1627 LELTQKMAMLQEE 1639
E Q++ +L E
Sbjct: 2166 SEENQELVILDAE 2178
Score = 50.1 bits (118), Expect = 2e-05
Identities = 82/454 (18%), Positives = 194/454 (42%), Gaps = 45/454 (9%)
Query: 1217 SEKLKTIMKENTELVQKLSNYEQKIKESKKHVQET-----RKQNMILSDEAIKYKDKIKT 1271
+++L I + + QK+S +E ++KES+ + QE +KQ L E + K +++
Sbjct: 69 NQRLMEICESLEKTKQKIS-HELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELER 127
Query: 1272 LEKNQEILDDTAKNLRV--------MLESEREQNVKNQDLISENKKSIEKLK----DVIS 1319
++ + D + + S+ K +DL + K +E+ K +V +
Sbjct: 128 SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA 187
Query: 1320 MNASEFSEV--QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIE-DWSKLHAE 1376
+ A + S+ Q +N ++ + S Q+E + I D+S +
Sbjct: 188 LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247
Query: 1377 LSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELAN 1436
+++ S+ L++ +D N + N + L + +++++ N+ +
Sbjct: 248 GEQEVTP---SRSTLQIG--KRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ 302
Query: 1437 GEVGGDRNEKMKNQIK--QMMDVSRTQTAISVVEEDLKLLQLK---LRASV-----STKC 1486
G ++MK Q+ Q + + + + ++E++ L + + +R + STK
Sbjct: 303 GH-----EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY 357
Query: 1487 N-LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYER 1545
LE ++KKL +D L + E +L QK++ + +Q++ Q+ + E
Sbjct: 358 TALEQKLKKLTED---LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
Query: 1546 QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKA 1605
+ + RL+ ++A + ++ ++ ++ +L+ FK ++ E+ + +K
Sbjct: 415 IQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
R++ E K+E L+ + +++ L+ E
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Score = 48.1 bits (113), Expect = 8e-05
Identities = 81/391 (20%), Positives = 166/391 (42%), Gaps = 41/391 (10%)
Query: 1243 ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVK--- 1299
E + ++ K + IL + + +++ ++ L + L V ++ E E+N+
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEENLMKAE 871
Query: 1300 --NQDLISENKKSIEKLKDVISMNASEFSEVQIALN----EAKLSEEKVKSE---CHRVQ 1350
+Q ++E + I KL++ S + + +E AL E +L +KV++E ++
Sbjct: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK 931
Query: 1351 EENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCIT 1410
+ N L+ ++LQ E S E+S I +++++E LT ++ + + +
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSII---SLNKREIE-ELTQENGTLKEINASLN 987
Query: 1411 Q--LNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVE 1468
Q +NL++ +SES D E + E+ ++ + ++ + T A +
Sbjct: 988 QEKMNLIQ-KSESFANY---IDEREKSISELS---DQYKQEKLILLQRCEETGNAYEDLS 1040
Query: 1469 EDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQ 1528
+ K Q K + +C L + E+ +N L+ K E + K+ E Q
Sbjct: 1041 QKYKAAQEK---NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
Query: 1529 QKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDE----LQKTE 1584
+ L+ + ++ R E + + +A +E+ T K +M+ E LQ+ E
Sbjct: 1098 NLMLELE---TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENE 1154
Query: 1585 RSFKNQIATHEKKAHE-----NWLKARAAER 1610
+ K HE + E N +K R +ER
Sbjct: 1155 QLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Score = 39.3 bits (90), Expect = 0.037
Identities = 95/506 (18%), Positives = 205/506 (40%), Gaps = 55/506 (10%)
Query: 1204 VKDRVYQVTEQQIS--EKLKTIMKENTELVQKLSNYEQKIKESKK--HVQETRKQNMI-- 1257
+KD E+ IS +L T +N L L K+ E +K + + K ++
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 1258 LSD---EAI----KYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKS 1310
L+D E I K +++ L +IL+D + L L + + ++ S
Sbjct: 1321 LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS 1380
Query: 1311 IEKLKDVISMNASEFSEVQIALNEAKLSEE--KVKSECHRVQEENARLKKKKEQLQQEIE 1368
+ L + S S+ ++ ++ A+L E+ ++SE + +++ ++ K +LQ ++
Sbjct: 1381 LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD 1440
Query: 1369 DWSKLHAELSEQIKSFEKSQKDL--EVALTHKDDNINALTNCITQLNLLECESESEGQNK 1426
+ LS +++F Q DL E+ L ++ + +L++ C +S +
Sbjct: 1441 SLKAENLVLSTNLRNF---QGDLVKEMQLGLEEGLVPSLSS--------SCVPDSSSLSS 1489
Query: 1427 GGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVE-EDLKLLQLKLRASVSTK 1485
G+ S A E GD + + + ++ VS Q ++ V L+ L + + S
Sbjct: 1490 LGDSSFYRALLEQTGDMS--LLSNLEGA--VSANQCSVDEVFCSSLQEENLTRKETPSAP 1545
Query: 1486 CNLEDQVKKL-EDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYE 1544
++++ L E R SL+ + +E + ++++ L +L + L Q E
Sbjct: 1546 AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE 1605
Query: 1545 RQEREHRLSAA----DEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHE 1600
++ + +L++ + K + ++ + +E +LQ + S ++ + + A +
Sbjct: 1606 NEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQ 1665
Query: 1601 NWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGP 1660
++ + E E +H + ++ K A I K
Sbjct: 1666 GRNESCDISKEHTSETTERTP-KHDVHQICDKDAQQDLNLDIEK---------------- 1708
Query: 1661 LSQNGSFGPSPVSGGECSPPLTVEPP 1686
+++ G+ P+ GE SP EPP
Sbjct: 1709 ITETGAVKPTGECSGEQSPDTNYEPP 1734
Score = 36.2 bits (82), Expect = 0.31
Identities = 86/463 (18%), Positives = 181/463 (39%), Gaps = 79/463 (17%)
Query: 1228 TELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLR 1287
T +QK+ E ++ + KK Q+ +Q + S EA K K K + E + +N R
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQ--RQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71
Query: 1288 VMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECH 1347
+M E +S+EK K IS E+Q+ ++ E ++ S
Sbjct: 72 LM----------------EICESLEKTKQKIS------HELQVKESQVNFQEGQLNSGKK 109
Query: 1348 RVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHK--------D 1399
++++ LK+ K +L++ + + A++S + QK LT +
Sbjct: 110 QIEKLEQELKRCKSELERSQQ--AAQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYE 165
Query: 1400 DNINALTNCITQLNLLECESESEGQNKGG--------NDSD---ELANGEVGGDRNEKMK 1448
D + + LE E ++ K N D A+ V + EK
Sbjct: 166 DLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
Query: 1449 NQI---KQMMDVSRTQTAI-----SVVEEDLKLLQLKLRASVS------TKCNLEDQVKK 1494
+ + Q + R +A V LQ+ R + S + +L DQ+K
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 1495 LEDD-RNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREH--- 1550
+ RN + + L+ K ++ +V EL Q E A + + +E+ + R+
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
Query: 1551 ----------RLSAADEKAVSAAEEVKTYKRRIE----EMEDELQKTERSFKNQIATHEK 1596
+ +A ++K E++ ++ E +E ++++ E+ F+ +++ ++
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 1597 KAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
+ + + +E ++A N+ + L K+ ++++
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 85.5 bits (210), Expect = 5e-16
Identities = 219/1105 (19%), Positives = 434/1105 (39%), Gaps = 158/1105 (14%)
Query: 612 EHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQM 671
E +R+EL+E++V Q ++ DL +++ E L ++ D Q+
Sbjct: 871 EAKRKELEEKMVTLMQ--------EKNDLQLQVQAEADALADA---EERCDQLIKTKIQL 919
Query: 672 SEKIR-LSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEE- 729
KI+ ++E E+ ++ E K E + + D L+KVE++ + +E
Sbjct: 920 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK-DIDDLELTLAKVEKEKHATENK 978
Query: 730 ---LLEDENAIN---AKRSKEKNPGNQGRQFDVN-LQVPDRAVLGTIHPDPEIEES---- 778
L E+ ++ AK +KEK + Q ++ LQ+ + V ++E+
Sbjct: 979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDL 1038
Query: 779 ----KQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSI 834
+QE + +D E+ + ++ L +K ++ FE S+ I
Sbjct: 1039 EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI 1098
Query: 835 KIQTPELGEVFQNKDSDYLKNDNPEEHLKTS----GLAGEPEGELSKEDHENTEKYMGTE 890
+ + ++ + + + EE ++ A + +LS+E E +E+
Sbjct: 1099 EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 891 SQGSAAAE----------------PEDDSFHWTPHTSVEPGHSDKREDL-LIISSFFKEQ 933
SA E E H ++ H+D +L I S + +
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVK 1218
Query: 934 QSLQRFQKYFNVHELEALLQEMSSKLKS-AQQESLPYNMEKVLDKVFRASESQI-----L 987
Q L++ + + E+ L M + K+ A E + +E L ++ E Q L
Sbjct: 1219 QKLEKEKSELKM-EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277
Query: 988 SIAEKMLDTRVAE-NRDLGMNENNIFE----EAAVLDDIQDLIYFVRYKHSTAEETATLV 1042
S + L T E +R L + + + + A I++L K EET
Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL------KRQLEEETKA-- 1329
Query: 1043 MAPPLEEGLGGAMEEMQPLHED-NFSREKTAEL-------NVQVPEEPTHLDQRVIGDTH 1094
L L A + L E +E AEL N +V + T + I T
Sbjct: 1330 -KSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 1095 ASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILL-IYSFM 1153
E ++K ++ DA + E + AS+ + + + M
Sbjct: 1389 ELEEAKKKLAQR---------------LQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Query: 1154 FYLTKSLVATLP-DDVQPGPDFYGLPWKPVF--ITAFLGIASFAIFLWRTVLVVKDRVYQ 1210
+ +S A + D Q D WK + A L + T L Y+
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYE 1493
Query: 1211 VTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK 1270
+ + L+T+ +EN L Q++S+ ++I E KH+ E K L E + + ++
Sbjct: 1494 ----ESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLE 1549
Query: 1271 TLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
E + E + K LR+ LE + ++ ++ I+E + +++LK N E
Sbjct: 1550 EAEASLE--HEEGKILRIQLELNQVKSEIDRK-IAEKDEELDQLK----RNHLRVVESMQ 1602
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIE-DWSKLHAELSEQIKSFEKSQK 1389
+ +A++ R + + R+KKK E E+E + + + +E +++ +Q
Sbjct: 1603 STLDAEI----------RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQG 1652
Query: 1390 DLEVALTHKDDNINALTNCITQL-------NLLECESES-----EGQNKGGNDSD-ELAN 1436
L+ H DD I + QL NL++ E E E +G ++ EL +
Sbjct: 1653 ILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLD 1712
Query: 1437 G----EVGGDRNEKMKNQIKQM-MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQ 1491
++ +N + N K++ D+S+ Q + + ++ + + K + +++ + ++
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEE 1772
Query: 1492 VKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHR 1551
+KK +D L+ K +E K L+ + L+E Q +K++ + E +E E
Sbjct: 1773 LKKEQDTSAHLERMKKNMEQTVKDLQLR---LDEAEQLALKGGKKQIQKLEARVRELESE 1829
Query: 1552 LSAADEKAVSAAEEVKTYKRRIEEME-----------------DELQKTERSFKNQIATH 1594
+ + + V A + ++ ++RR++E+ D+LQ +++K Q
Sbjct: 1830 VESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEA 1889
Query: 1595 EKKAHENWLKARAAERAIAEEKREA 1619
E++++ N K R + + E K A
Sbjct: 1890 EEQSNVNLAKFRKLQHELEEAKERA 1914
Score = 78.6 bits (192), Expect = 6e-14
Identities = 90/433 (20%), Positives = 190/433 (43%), Gaps = 70/433 (16%)
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEI 1278
K+K ++K + E ++++N +++ +++K+ + +T + L ++ + + L+ +
Sbjct: 839 KIKPLLK-SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQA 897
Query: 1279 LDDTAKNLRVMLESEREQNVKNQ-DLISENKKSIEKLKDVISMNASEFSEVQIALNEAKL 1337
D + E +Q +K + L ++ K+ E+ +D +NA ++ + KL
Sbjct: 898 EADALADA----EERCDQLIKTKIQLEAKIKEVTERAEDEEEINA------ELTAKKRKL 947
Query: 1338 SEE--KVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVA- 1394
+E ++K + ++ A+++K+K + ++++ ++ A L E I K +K L+ A
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 1395 ------LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMK 1448
L ++D +N LT T+L + D ++
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLE------------------------QQVDDLEGSLE 1043
Query: 1449 NQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAG 1508
+ K MD+ R + + E DLKL Q + + K L +++KK E + ++LQ
Sbjct: 1044 QEKKLCMDLERAKRKL---EGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGK--- 1097
Query: 1509 LEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKT 1568
+EDE Q + LQKK+ + + +E E + A A ++
Sbjct: 1098 IEDE---------------QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK--- 1625
R +EE+ + L++ + QI ++K+ E R E + + + AA LR K
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 1626 -LLELTQKMAMLQ 1637
+ EL +++ LQ
Sbjct: 1203 SVAELGEQIDSLQ 1215
Score = 73.6 bits (179), Expect = 2e-12
Identities = 96/474 (20%), Positives = 202/474 (42%), Gaps = 52/474 (10%)
Query: 1197 LWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNM 1256
L +T + ++ ++ +VTE+ E+ + N EL K E + E KK + +
Sbjct: 912 LIKTKIQLEAKIKEVTERAEDEE-----EINAELTAKKRKLEDECSELKKDIDDLELTLA 966
Query: 1257 ILSDEAIKYKDKIKTLEKNQEILDDTAKNL---RVMLESEREQNVKNQDLISENKKSIEK 1313
+ E ++K+K L + LD+T L + L+ +Q + + + + ++ K
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTK 1026
Query: 1314 LK-----DVISMNASEFSEVQIALN----------EAKLSEEKVKSECHRVQEENARLKK 1358
K V + S E ++ ++ + KL++E + Q+ N +LKK
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKK 1086
Query: 1359 KK---EQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLL 1415
K+ LQ +IED L +L ++IK + ++LE + + + + L+
Sbjct: 1087 KEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 1416 ECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQ-------MMDVSRTQTAISVVE 1468
E + GG S ++ + +KM+ +++ R + A SV E
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE 1206
Query: 1469 --EDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNEL 1526
E + LQ + K L+ ++ L + ++ AKA E C+TL ++ +
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266
Query: 1527 YQQKEMALQKKLSQE--------EYERQ--EREHRLSAADEKAVSAAEEVKTYKRRIEEM 1576
++++ + + +Q+ E+ RQ E++ +S + ++++ KR++E
Sbjct: 1267 EEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE-- 1324
Query: 1577 EDELQKTERSFKNQIATHE----KKAHENWLKARA-AERAIAEEKREAANLRHK 1625
E+ K+ + Q A H+ ++ +E +A+A +R +++ E A R K
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTK 1378
Score = 67.8 bits (164), Expect = 1e-10
Identities = 93/439 (21%), Positives = 185/439 (42%), Gaps = 29/439 (6%)
Query: 1210 QVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKI 1269
+ +++ EK+ T+M+E +L ++ + ++++ + K + L K K+
Sbjct: 871 EAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLE---AKIKEVT 927
Query: 1270 KTLEKNQEILDD-TAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEV 1328
+ E +EI + TAK + LE E + K+ D + +EK K +E
Sbjct: 928 ERAEDEEEINAELTAKKRK--LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 1329 QIALNE--AKLSEEK-VKSECHR-------VQEENAR-LKKKKEQLQQEIEDWSKLHAEL 1377
L+E AKL++EK E H+ ++E+ L K K +L+Q+++D +
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 1378 SEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANG 1437
+ E++++ LE L ++ N QLN + E E N G DE A
Sbjct: 1046 KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALA 1105
Query: 1438 EVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLED 1497
+ ++++ +I+++ + + A E K R+ +S + LE+ ++LE+
Sbjct: 1106 IQLQKKIKELQARIEELEEEIEAERASRAKAE-------KQRSDLSRE--LEEISERLEE 1156
Query: 1498 DRNSLQAA---KAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSA 1554
+ A E E + +R+ +E ++ AL+KK + E E+ L
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216
Query: 1555 ADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAE 1614
+K E+K + + + K + +F+ T E + E K +R I E
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276
Query: 1615 EKREAANLRHKLLELTQKM 1633
+ A L + E ++++
Sbjct: 1277 LSAQKARLHTESGEFSRQL 1295
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/464 (21%), Positives = 197/464 (42%), Gaps = 51/464 (10%)
Query: 1209 YQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRK---QNMILSDEAIK- 1264
Y+ ++ +E + + K N+E+ Q + YE + + ++E +K Q + ++E ++
Sbjct: 1351 YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 1265 YKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASE 1324
K +LEK ++ L + ++L M++ ER N I+ +KK V++ +
Sbjct: 1411 VNSKCASLEKTKQRLQNEVEDL--MIDVERS----NAACIALDKKQ-RNFDKVLAEWKQK 1463
Query: 1325 FSEVQIALNEAKLSEEKVKSECHRVQ---EENA----RLKKKKEQLQQEIEDWSKLHAEL 1377
+ E Q L ++ + +E +V+ EE+ LK++ + LQQEI D ++ AE
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG 1523
Query: 1378 SEQIKSFEKSQKDL--------------EVALTHKDDNINALTNCITQLNLLECESESEG 1423
+ I EK +K L E +L H++ I + QL L + +SE +
Sbjct: 1524 GKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI-----QLELNQVKSEIDR 1578
Query: 1424 Q-NKGGNDSDELANG--EVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKL-- 1478
+ + + D+L V + +I+ D R + +E DL ++++L
Sbjct: 1579 KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK---KKMEGDLNEMEIQLNH 1635
Query: 1479 --RASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQK 1536
R + NL + L+D + L A G +D+ K VE L Q + L+
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRG-QDDLKEQLAMVERRANLMQAEVEELRA 1694
Query: 1537 KLSQEEYERQEREHRLSAADEKAV---SAAEEVKTYKRRIEEMEDELQKTERSFKNQIAT 1593
L + E R+ E L A E+ + + K+++E ++Q +
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARN 1754
Query: 1594 HEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQ 1637
E+KA + A + +E+ +A+L + Q + LQ
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ 1798
Score = 40.8 bits (94), Expect = 0.013
Identities = 223/1201 (18%), Positives = 435/1201 (36%), Gaps = 176/1201 (14%)
Query: 206 TQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKT-----SNSSQVSNEQDK 260
T+K ++ + + E A E+ + L++K+ E N + + +++ +++
Sbjct: 849 TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEER 908
Query: 261 IDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEE 320
D +L+K ++ L+ K K E T E++ + EL + + E E
Sbjct: 909 CD--QLIKTKIQLEAKIK------------EVTERAED-EEEINAELTAKKRKLEDECSE 953
Query: 321 NQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNIL 380
++D D+L L T AK EK+ T+ + + E+ L +K L
Sbjct: 954 LKKDIDDLEL----------TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1003
Query: 381 TTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNV 440
+ E+ +T+ + E++ +D + +L + K
Sbjct: 1004 QEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKK---------------- 1047
Query: 441 DDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQ----EGMTVH 496
+D+ + A+ ++G + QES DK +L ++ + E +
Sbjct: 1048 ----LCMDLER--------AKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQ 1095
Query: 497 SSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSES 556
+ ++ +K K+ L++ ++ E +++ +K ++ E
Sbjct: 1096 GKIEDEQALAIQLQKKIKE-LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 557 ESAQKAAGNQMNDRKIQQ-------ESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHTL 609
E A A Q+ K ++ L + L + A R G ++ +L
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSL 1214
Query: 610 S-----VEHQREELKEELVLKTQNQPRFSSPDEI--DLPRELEDEVPILGRNLPWQQE-- 660
+E ++ ELK E+ N S + R LED++ + QQ
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274
Query: 661 RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAM--QGTEVGQTDQTDSTGGPAFLS 718
+++A ++ +E S ++D++ + K Q E + + T + L+
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334
Query: 719 KVEEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEES 778
+ +LL ++ + E G +V Q + I E+EE+
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV-AQWRTKYETDAIQRTEELEEA 1393
Query: 779 KQETSMILDS-----EKTSETAAKGVNTGGREPNT----MVEKERP----LADKKAQRPF 825
K++ + L E + A T R N M++ ER +A K QR F
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 826 ERSDFSDSIKIQTPELGEVFQNKDSDYL-------KNDNPE--EHLKTSGLAGEPEGELS 876
++ K + + K+S L KN E +HL+T + L
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK---NLQ 1510
Query: 877 KEDHENTEKYM--GTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQ 934
+E + TE+ G + + D TS+E + S E+
Sbjct: 1511 QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEA----------SLEHEEG 1560
Query: 935 SLQRFQKYFNV--HELEALLQEMSSKLKSAQQESLPY--NMEKVLDKVFRASESQILSIA 990
+ R Q N E++ + E +L ++ L +M+ LD R S + L I
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIR-SRNDALRIK 1619
Query: 991 EKML-DTRVAE------NRDLGMNENNIFEEAAVLDDIQ-DLIYFVRYKHSTAEETATLV 1042
+KM D E NR N+ +L D Q L +R + E+ A +
Sbjct: 1620 KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE 1679
Query: 1043 MAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKP 1102
L + +EE++ E K AE + E L + + S ++ K
Sbjct: 1680 RRANLMQA---EVEELRASLERTERGRKMAEQELLDASERVQL----LHTQNTSLINTKK 1732
Query: 1103 NTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVA 1162
E D+ ED +A +A ++ + A + A + + + + K++
Sbjct: 1733 KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1792
Query: 1163 TLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKT 1222
T+ D L A G + + ++ RV ++ + SE+
Sbjct: 1793 TVKD--------LQLRLDEAEQLALKGGK-------KQIQKLEARVRELESEVESEQ--- 1834
Query: 1223 IMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDT 1282
K N E V+ L +E+++KE +E RK + L D K + K+K ++ E
Sbjct: 1835 --KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE----- 1887
Query: 1283 AKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAK---LSE 1339
E+E + NV N + + +E+ K+ + S+ +++++ E +SE
Sbjct: 1888 --------EAEEQSNV-NLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938
Query: 1340 E 1340
E
Sbjct: 1939 E 1939
Score = 40.4 bits (93), Expect = 0.017
Identities = 43/194 (22%), Positives = 90/194 (46%), Gaps = 29/194 (14%)
Query: 1446 KMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAA 1505
K+ +IK ++ + T+ ++ ++E+ + + +L + + + LE+++ L ++N LQ
Sbjct: 835 KLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 1506 KAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEE 1565
++ E L E ++L + K + L+ K+ +E ER E E ++A E
Sbjct: 895 ---VQAEADALADAEERCDQLIKTK-IQLEAKI-KEVTERAEDEEEINA----------E 939
Query: 1566 VKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHK 1625
+ KR++E+ EL+K + +A EK+ H K + NL +
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK--------------NLTEE 985
Query: 1626 LLELTQKMAMLQEE 1639
+ L + +A L +E
Sbjct: 986 MAGLDETIAKLTKE 999
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 85.1 bits (209), Expect = 6e-16
Identities = 93/441 (21%), Positives = 193/441 (43%), Gaps = 34/441 (7%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
+ +I++K +K+ EL +S+ ++ + + + KQ L +E K ++
Sbjct: 1100 DDEIAQK-NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL--- 1155
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
++ LD TA + + E+E V + L E + +++++ +A E+ L
Sbjct: 1156 ---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLE 1392
+ K ++ + +++ENA L + L Q ++ +L Q++ + D E
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 1393 VALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIK 1452
A +D ++ L N + + + E+E + D + D E ++ + +
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETR 1329
Query: 1453 QMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLE-----------DQVKKLEDDRNS 1501
Q ++VS T + +EE+ LQ +L + K NLE D KKL+D ++
Sbjct: 1330 QKLNVS---TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 1502 LQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVS 1561
++A LE+ K ++++E L + Y++K A K + +QE + + D +
Sbjct: 1387 VEA----LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-Q 1441
Query: 1562 AAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAAN 1621
++ +R+ +++ E + + ++ E +A E KA + RA+ EE EA
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEA-- 1498
Query: 1622 LRHKLLELTQKMAMLQEEPVI 1642
+ LE T KM + E ++
Sbjct: 1499 --KEELERTNKMLKAEMEDLV 1517
Score = 84.0 bits (206), Expect = 1e-15
Identities = 100/468 (21%), Positives = 207/468 (44%), Gaps = 64/468 (13%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++ ++ + + E ++ Q++ + E++++E +E +Q + L E + + KIK LE
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQL--EKVTAEAKIKKLE 984
Query: 1274 KNQEILDDTAKNL---RVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
++DD L R +LE N E K++ KLK + + S SE+++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK---NKHESMISELEV 1041
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE----K 1386
L + EEK + E L+K K +L+ + D+ + A+L QI + K
Sbjct: 1042 RLKK----EEKSRQE----------LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLE---------CESESEGQNKGGNDSDELANG 1437
+++L+ AL DD I N + ++ LE +SE +NK +L
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1144
Query: 1438 EVGGDRNEKMKNQIKQMMDVSRTQTAISVV-EEDLKLLQLKL-RASVSTKCNLEDQ---- 1491
G+ E +K +++ +D + TQ + E+++ +L+ L + S + +++
Sbjct: 1145 ---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 1492 ---VKKLEDDRNSLQAAKAGLEDECKTL-RQKVEILNEL--YQQKEMALQKKLSQEEYER 1545
V++L + + AKA L+ +TL ++ ++ EL Q + ++ K + E +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 1546 QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKA 1605
QE + + S + ++V + +E + L + E + K +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE----GKAIKLAKDVASLSSQL 1317
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQ 1653
+ + + EE R+ N+ KL +L ++ LQ++ + + M K N +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ--LDEEMEAKQNLE 1363
Score = 73.6 bits (179), Expect = 2e-12
Identities = 90/459 (19%), Positives = 213/459 (46%), Gaps = 56/459 (12%)
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILS-DEAIKYKDKI----KTLE 1273
K ++ E + K ++ E+ E++ +ET+ ++ + +EA++ K+++ K L+
Sbjct: 1452 KFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 1274 KNQEIL----DDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
E L DD KN+ + +S+R + +++ K +E+L+D + A+E ++++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLEELED--ELQATEDAKLR 1564
Query: 1330 IALNEAKLS---EEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEK 1386
+ +N L E +++ + +E+ +L+++ + + E+ED K A + K E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLECESES---EGQNKGGNDSDELANGEVGGDR 1443
KDLE+ D I I QL L+ + + E ++ + + A + +
Sbjct: 1625 DLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 1444 NEKMKNQIKQMM-DVSRTQTAISVVEEDLKLLQLKLRASVSTK--------------CNL 1488
+ ++ + Q+ D++ + A + + + L +L +S+S + L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 1489 EDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER 1548
E++ LE+++ +++A + K +Q ++ NEL ++ A + + ++++ ERQ +
Sbjct: 1742 EEE---LEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 1549 E-----HRLSAADE---KAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHE 1600
E H + A + K+ AA E K ++EE ++ + +++ + +KK E
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 1601 NWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
L+ + + K +A ++ +L +++ +EE
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 70.9 bits (172), Expect = 1e-11
Identities = 81/395 (20%), Positives = 167/395 (42%), Gaps = 28/395 (7%)
Query: 1212 TEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT 1271
T + + +++ ++ ++ + + E+ + + ++E + Q L DE +D
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1272 LEKNQEILDDT-AKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE N + L ++L+ E E+ + Q + E + +E + ++ A+ +++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD 1390
L + +L + ++ +L+ + + Q+E+ED E+ K EK K
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 1391 LEVALTHKDDNINALTNCITQLNL------LECESESEGQNKGGND-------------- 1430
LE L +++ A Q +L E S G+N ++
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 1431 -SDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN-L 1488
+E N E DR K Q +Q+ + T+ + + E + + + +K + +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1489 EDQVK-KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
E VK K + +L+A A LE++ + ++ + + +QK+ L++ L Q E ER+
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
E E+A VK KR++EE E+E Q+
Sbjct: 1865 AEQ----YKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Score = 60.8 bits (146), Expect = 1e-08
Identities = 99/491 (20%), Positives = 205/491 (41%), Gaps = 94/491 (19%)
Query: 1223 IMKENTELVQKLSNYE--QKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILD 1280
+++ N KL N++ + + K +Q TR++ + + E D+++ ++ Q+ +
Sbjct: 818 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE-----DELQKTKERQQKAE 872
Query: 1281 DTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEE 1340
+ K L E + Q + ++L+ E ++ +L +E E+++ L K E
Sbjct: 873 NELKEL----EQKHSQLTEEKNLLQEQLQAETELY-------AEAEEMRVRLAAKKQELE 921
Query: 1341 KVKSECH-RVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ----------- 1388
++ E R++EE R +QLQ E + ++ +L EQ++ E ++
Sbjct: 922 EILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 1389 ---KDLEVALTHKDDNINALT-------NCITQL--NLLECESESEGQNKGGNDSDELAN 1436
K LE + DD N L+ I+ L NL E E +++ K N + + +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 1437 G-EVGGDRNEKMKNQIKQM-------------------MDVSRTQTAISVVEEDLKLLQL 1476
EV + EK + +++++ ++ + ++ EE+L+
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 1477 KLRASVSTKCN-------LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL------ 1523
+L ++ K N LE + L++D +S +AA+ E + + L +++E L
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 1524 --------NELYQQKEM---ALQKKLSQE----EYERQEREHRLSAADEKAVSAAEEVKT 1568
EL ++E L+K L +E E + QE + + A E+ E+ K
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
K +++ + L+K ++ + E K + E + E + + ++ E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 1629 LTQKMAMLQEE 1639
L K+ LQ E
Sbjct: 1278 LNDKVHKLQNE 1288
Score = 57.0 bits (136), Expect = 2e-07
Identities = 147/826 (17%), Positives = 316/826 (38%), Gaps = 116/826 (14%)
Query: 99 KDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAV 158
K L+QV + +EE+Q DE + E L LE +S T+ + +
Sbjct: 842 KPLLQVTRQ--EEEMQAKEDELQ-------KTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 159 EKTLQD---------------MEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQ 203
++ LQ K EL + +E + + +E + Q+
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 204 FTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDA 263
++ + Q E+ + E+ + L+D++ V + +NNK S
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER----------- 1001
Query: 264 YKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQE 323
KLL++ ++ DL T L ++E + +T L++ E + +E K++E++++
Sbjct: 1002 -KLLEERIS-DLTTN-------LAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1051
Query: 324 DFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTW 383
+ ++L D D + K Q + +E+++Q + + DD+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL---ARLDDE------ 1102
Query: 384 GDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSD--PDNVD 441
I + +LE S+ +++ D + + + + + + + ++
Sbjct: 1103 ------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 442 DGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHS 501
D L D T + E + + + E R E+ ++ + + +
Sbjct: 1157 DTL---DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 502 NNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGE-QILEGGSESESAQ 560
+ +K K TL+ D +L+ + + H++K E Q+ E S+ +
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 561 KAAGNQMNDR--KIQ----------QESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+A ++ND+ K+Q E+ G A + D + S + L+
Sbjct: 1273 RARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 609 LSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQER--DVAAT 666
L+V + +L+EE +N + +E++ + LE + L L +++ D A+T
Sbjct: 1332 LNVSTKLRQLEEE-----RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 667 ASKQMSEKIRL-SEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDS-----TGGPAFLSKV 720
K R E E +E+ + ++ T+ + D +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 721 EEDDYPSEELLEDENAINAKRSKEKNPGN-QGRQFDVNLQVPDRAVLGTIHPDPEIEESK 779
E+ ++LL +E I++K + E++ + R+ + RA+ + E +E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEEL 1502
Query: 780 QETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTP 839
+ T+ +L +E ++K + G+ + + + +R L + + +K Q
Sbjct: 1503 ERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALETQ-----------MEEMKTQLE 1549
Query: 840 ELGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEK 885
EL + Q + L+ + + L G+ E +L D +N EK
Sbjct: 1550 ELEDELQATEDAKLRLE-----VNMQALKGQFERDLQARDEQNEEK 1590
Score = 43.1 bits (100), Expect = 0.003
Identities = 230/1258 (18%), Positives = 450/1258 (35%), Gaps = 214/1258 (17%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKH-HSHANSQA 217
E+ +Q E + +KER+ + E E+ S +E LQEQ + ++ A
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 218 NHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKT 277
++ E ++ +L+ E + + + + Q +D + L++E K
Sbjct: 911 VRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 278 KFGS-TADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDG 336
+ TA+A + E LV +D + + KE + +E +L +
Sbjct: 970 QLEKVTAEAKIKKLEDEILV----------MDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 337 EDMK--TPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGG 394
E K T K+ E ++ E +E+K + + +K + + + + I +
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1078
Query: 395 EETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNN 454
E + + + + DD + + K + D +D
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED-----------L 1127
Query: 455 DKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGK 514
D E A + + + R + E L KTELED T+ S+ L + E+
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEAL---KTELED------TLDSTATQQELRAK--REQEV 1176
Query: 515 DTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGN-QMNDRKIQ 573
LK A D+ H ++ +K + + E + E ++A N N + ++
Sbjct: 1177 TVLKKALDEETRS------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 574 QESL---GSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP 630
+E+ G ++G + +A V + E R EL ++ V K QN+
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEV 1289
Query: 631 RFSSP---DEIDLPRELEDEVPILGRNLPWQQERDVAATASK-QMSEKIRLSEGEAK--E 684
+ + +L +V L L QE T K +S K+R E E +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 685 DSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSE-ELLEDENAINAKRSK 743
D LDEE +A Q E + SK + D+ S E LE+ K+
Sbjct: 1350 DQLDEEM---EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEE-----GKKRF 1397
Query: 744 EKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSETAAKGVNTGG 803
+K N +Q++ D+ +E++K LD
Sbjct: 1398 QKEIENLTQQYEEKAAAYDK-----------LEKTKNRLQQELDDLVVD----------- 1435
Query: 804 REPNTMVEKERPLAD--KKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKNDNPEEH 861
++ +R L +K QR F D + + + + + + D + + E+
Sbjct: 1436 ------LDNQRQLVSNLEKKQRKF------DQLLAEEKNISSKYAD-ERDRAEAEAREKE 1482
Query: 862 LKTSGLAGEPEGEL-SKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKR 920
K LA E L +KE+ E T K + E + +++ +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK----------------- 1525
Query: 921 EDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR 980
NVHELE S + Q E + +E++ D++ +
Sbjct: 1526 -----------------------NVHELEK-----SKRALETQMEEMKTQLEELEDEL-Q 1556
Query: 981 ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETAT 1040
A+E L + M + RDL + E+ L Y+ +E
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-----QLHEYETELEDERKQ 1611
Query: 1041 LVMAPPLEEGLGGAMEEMQPLHEDNFSREKTA-----ELNVQVPEEPTHL-DQRVIGDTH 1094
+A ++ L G +++++ + + A +L Q+ + L D R D
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1095 ASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQP----ETAAEEPASVTPLENAILLIY 1150
+ + K L+ + ++ A A KQ E AEE AS NA+
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1151 SFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQ 1210
+ ++ +A L ++++ + + DRV +
Sbjct: 1732 RRL----EARIAQLEEELEEEQG--------------------------NMEAMSDRVRK 1761
Query: 1211 VTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK 1270
T+Q +E+L + QK + Q+++ K ++ K + + K+K I
Sbjct: 1762 ATQQ--AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIA 1817
Query: 1271 TLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE L++ + + RE+ + L ++KK LK+++ E +
Sbjct: 1818 ALEAKIAQLEEQVE------QEAREKQAATKSLKQKDKK----LKEILLQVEDERKMAEQ 1867
Query: 1331 ALNEAKLSEEKVKS---ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE 1385
+A+ +VK + +EE+ R+ + +LQ+E+++ ++ + + ++ + +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Score = 42.7 bits (99), Expect = 0.003
Identities = 204/1154 (17%), Positives = 438/1154 (37%), Gaps = 166/1154 (14%)
Query: 329 PLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIF 388
PLL T E+ + ++K T + Q E + +L ++KN+L
Sbjct: 843 PLLQVTRQEEEMQAKEDELQK--TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 389 SIVTGGEETRDTMDLESSSSEE---------EKEDDDDALVPDSKQGKPQSATDYSDPDN 439
+ EE R + + EE E+E+D + ++ Q D +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 440 VDDG----LFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDK-----TEL--EDE 488
++ L + + K++ E + +R L++++ T L E+E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 489 NQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQ 548
+ +T + H + ++ + K ++ + + + L+G A + + + +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 549 ILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+ ++ E +AA +++D Q+ + + H + ++ ++ +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135
Query: 609 LSVEHQREELKEEL-VLKTQNQPRF-SSPDEIDLPRELEDEVPILGRNLPWQQERDVAAT 666
E Q+ +L EEL LKT+ + S+ + +L + E EV +L + L D
Sbjct: 1136 -KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL------DEETR 1188
Query: 667 ASKQMSEKIRLSEGEAKEDSLD--EEFFHHKAM--QGTEVGQTDQTDSTGGPAFLSKVEE 722
+ + +++R +A E+ + E+F KA + + + + D G L + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 723 DDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQET 782
+ ++ LE + + + K + + ++N +V E + T
Sbjct: 1249 EVEHKKKKLEAQ----VQELQSKCSDGERARAELNDKVHKLQ-----------NEVESVT 1293
Query: 783 SMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELG 842
M+ ++E + AK V + ++ ++ + L ++ + ++ + S ++ E
Sbjct: 1294 GMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR---QKLNVSTKLRQLEEERN 1346
Query: 843 EVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDD 902
+ D + N E H+ T + SK+ ++ + +G + E +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 903 SFHWTPHTSVEPGHSDKRE----------DLLIISSFFKEQ--QSLQRFQKYFNVHELEA 950
+ T + DK E D L++ + Q +L++ Q+ F+ +L A
Sbjct: 1403 NL--TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1458
Query: 951 LLQEMSSKL---------KSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTR---- 997
+ +SSK ++ ++E+ ++ + L++ A E L KML
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDL 1516
Query: 998 VAENRDLGMN-----------ENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPP 1046
V+ D+G N E + E L++++D + A E A L +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--------ATEDAKLRLEVN 1568
Query: 1047 LEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEK 1106
++ G ++Q E N EK +L Q+ E T L+ A + K E
Sbjct: 1569 MQALKGQFERDLQARDEQN--EEKRRQLQRQLHEYETELEDE--RKQRALAAAAKKKLEG 1624
Query: 1107 DLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPD 1166
DL +D + A A K E A ++ + + AT +
Sbjct: 1625 DL-------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 1167 DVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKE 1226
+ + L + + L A A + + K+ + + +S + + E
Sbjct: 1678 NEKKAKS---LEADLMQLQEDLAAAERAR---KQADLEKEELAEELASSLSGR-NALQDE 1730
Query: 1227 NTELVQKLSNYEQKIKESKKH-------VQETRKQNMILSDEAIKYKDKIKTLEKNQEIL 1279
L +++ E++++E + + V++ +Q LS+E + + E ++ L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 1280 DDTAKNLRVML-ESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLS 1338
+ K LR L E E K + I+ + I +L++ + A E Q A K
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQK 1847
Query: 1339 EEKVKSECHRVQEE--------------NARLKKKKEQLQQEIEDWSKLHA-------EL 1377
++K+K +V++E NAR+K+ K QL++ E+ +++A EL
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 1378 SEQIKSFEKSQKDL 1391
E +S E +++
Sbjct: 1908 DEATESNEAMGREV 1921
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 85.1 bits (209), Expect = 6e-16
Identities = 93/441 (21%), Positives = 193/441 (43%), Gaps = 34/441 (7%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
+ +I++K +K+ EL +S+ ++ + + + KQ L +E K ++
Sbjct: 1107 DDEIAQK-NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL--- 1162
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
++ LD TA + + E+E V + L E + +++++ +A E+ L
Sbjct: 1163 ---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLE 1392
+ K ++ + +++ENA L + L Q ++ +L Q++ + D E
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 1393 VALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIK 1452
A +D ++ L N + + + E+E + D + D E ++ + +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETR 1336
Query: 1453 QMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLE-----------DQVKKLEDDRNS 1501
Q ++VS T + +EE+ LQ +L + K NLE D KKL+D ++
Sbjct: 1337 QKLNVS---TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 1502 LQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVS 1561
++A LE+ K ++++E L + Y++K A K + +QE + + D +
Sbjct: 1394 VEA----LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-Q 1448
Query: 1562 AAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAAN 1621
++ +R+ +++ E + + ++ E +A E KA + RA+ EE EA
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEA-- 1505
Query: 1622 LRHKLLELTQKMAMLQEEPVI 1642
+ LE T KM + E ++
Sbjct: 1506 --KEELERTNKMLKAEMEDLV 1524
Score = 84.0 bits (206), Expect = 1e-15
Identities = 100/468 (21%), Positives = 207/468 (44%), Gaps = 64/468 (13%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++ ++ + + E ++ Q++ + E++++E +E +Q + L E + + KIK LE
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQL--EKVTAEAKIKKLE 991
Query: 1274 KNQEILDDTAKNL---RVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
++DD L R +LE N E K++ KLK + + S SE+++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK---NKHESMISELEV 1048
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE----K 1386
L + EEK + E L+K K +L+ + D+ + A+L QI + K
Sbjct: 1049 RLKK----EEKSRQE----------LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLE---------CESESEGQNKGGNDSDELANG 1437
+++L+ AL DD I N + ++ LE +SE +NK +L
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1151
Query: 1438 EVGGDRNEKMKNQIKQMMDVSRTQTAISVV-EEDLKLLQLKL-RASVSTKCNLEDQ---- 1491
G+ E +K +++ +D + TQ + E+++ +L+ L + S + +++
Sbjct: 1152 ---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 1492 ---VKKLEDDRNSLQAAKAGLEDECKTL-RQKVEILNEL--YQQKEMALQKKLSQEEYER 1545
V++L + + AKA L+ +TL ++ ++ EL Q + ++ K + E +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 1546 QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKA 1605
QE + + S + ++V + +E + L + E + K +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE----GKAIKLAKDVASLSSQL 1324
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQ 1653
+ + + EE R+ N+ KL +L ++ LQ++ + + M K N +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ--LDEEMEAKQNLE 1370
Score = 73.6 bits (179), Expect = 2e-12
Identities = 90/459 (19%), Positives = 213/459 (46%), Gaps = 56/459 (12%)
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILS-DEAIKYKDKI----KTLE 1273
K ++ E + K ++ E+ E++ +ET+ ++ + +EA++ K+++ K L+
Sbjct: 1459 KFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 1274 KNQEIL----DDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
E L DD KN+ + +S+R + +++ K +E+L+D + A+E ++++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLEELED--ELQATEDAKLR 1571
Query: 1330 IALNEAKLS---EEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEK 1386
+ +N L E +++ + +E+ +L+++ + + E+ED K A + K E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLECESES---EGQNKGGNDSDELANGEVGGDR 1443
KDLE+ D I I QL L+ + + E ++ + + A + +
Sbjct: 1632 DLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 1444 NEKMKNQIKQMM-DVSRTQTAISVVEEDLKLLQLKLRASVSTK--------------CNL 1488
+ ++ + Q+ D++ + A + + + L +L +S+S + L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 1489 EDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER 1548
E++ LE+++ +++A + K +Q ++ NEL ++ A + + ++++ ERQ +
Sbjct: 1749 EEE---LEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 1549 E-----HRLSAADE---KAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHE 1600
E H + A + K+ AA E K ++EE ++ + +++ + +KK E
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 1601 NWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
L+ + + K +A ++ +L +++ +EE
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 70.9 bits (172), Expect = 1e-11
Identities = 81/395 (20%), Positives = 167/395 (42%), Gaps = 28/395 (7%)
Query: 1212 TEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT 1271
T + + +++ ++ ++ + + E+ + + ++E + Q L DE +D
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1272 LEKNQEILDDT-AKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE N + L ++L+ E E+ + Q + E + +E + ++ A+ +++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD 1390
L + +L + ++ +L+ + + Q+E+ED E+ K EK K
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 1391 LEVALTHKDDNINALTNCITQLNL------LECESESEGQNKGGND-------------- 1430
LE L +++ A Q +L E S G+N ++
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 1431 -SDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN-L 1488
+E N E DR K Q +Q+ + T+ + + E + + + +K + +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1489 EDQVK-KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
E VK K + +L+A A LE++ + ++ + + +QK+ L++ L Q E ER+
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
E E+A VK KR++EE E+E Q+
Sbjct: 1872 AEQ----YKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Score = 60.8 bits (146), Expect = 1e-08
Identities = 99/491 (20%), Positives = 205/491 (41%), Gaps = 94/491 (19%)
Query: 1223 IMKENTELVQKLSNYE--QKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILD 1280
+++ N KL N++ + + K +Q TR++ + + E D+++ ++ Q+ +
Sbjct: 825 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE-----DELQKTKERQQKAE 879
Query: 1281 DTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEE 1340
+ K L E + Q + ++L+ E ++ +L +E E+++ L K E
Sbjct: 880 NELKEL----EQKHSQLTEEKNLLQEQLQAETELY-------AEAEEMRVRLAAKKQELE 928
Query: 1341 KVKSECH-RVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ----------- 1388
++ E R++EE R +QLQ E + ++ +L EQ++ E ++
Sbjct: 929 EILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 1389 ---KDLEVALTHKDDNINALT-------NCITQL--NLLECESESEGQNKGGNDSDELAN 1436
K LE + DD N L+ I+ L NL E E +++ K N + + +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 1437 G-EVGGDRNEKMKNQIKQM-------------------MDVSRTQTAISVVEEDLKLLQL 1476
EV + EK + +++++ ++ + ++ EE+L+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 1477 KLRASVSTKCN-------LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL------ 1523
+L ++ K N LE + L++D +S +AA+ E + + L +++E L
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 1524 --------NELYQQKEM---ALQKKLSQE----EYERQEREHRLSAADEKAVSAAEEVKT 1568
EL ++E L+K L +E E + QE + + A E+ E+ K
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
K +++ + L+K ++ + E K + E + E + + ++ E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 1629 LTQKMAMLQEE 1639
L K+ LQ E
Sbjct: 1285 LNDKVHKLQNE 1295
Score = 57.0 bits (136), Expect = 2e-07
Identities = 147/826 (17%), Positives = 316/826 (38%), Gaps = 116/826 (14%)
Query: 99 KDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAV 158
K L+QV + +EE+Q DE + E L LE +S T+ + +
Sbjct: 849 KPLLQVTRQ--EEEMQAKEDELQ-------KTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 159 EKTLQD---------------MEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQ 203
++ LQ K EL + +E + + +E + Q+
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 204 FTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDA 263
++ + Q E+ + E+ + L+D++ V + +NNK S
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER----------- 1008
Query: 264 YKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQE 323
KLL++ ++ DL T L ++E + +T L++ E + +E K++E++++
Sbjct: 1009 -KLLEERIS-DLTTN-------LAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1058
Query: 324 DFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTW 383
+ ++L D D + K Q + +E+++Q + + DD+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL---ARLDDE------ 1109
Query: 384 GDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSD--PDNVD 441
I + +LE S+ +++ D + + + + + + + ++
Sbjct: 1110 ------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 442 DGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHS 501
D L D T + E + + + E R E+ ++ + + +
Sbjct: 1164 DTL---DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 502 NNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGE-QILEGGSESESAQ 560
+ +K K TL+ D +L+ + + H++K E Q+ E S+ +
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 561 KAAGNQMNDR--KIQ----------QESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+A ++ND+ K+Q E+ G A + D + S + L+
Sbjct: 1280 RARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 609 LSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQER--DVAAT 666
L+V + +L+EE +N + +E++ + LE + L L +++ D A+T
Sbjct: 1339 LNVSTKLRQLEEE-----RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 667 ASKQMSEKIRL-SEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDS-----TGGPAFLSKV 720
K R E E +E+ + ++ T+ + D +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 721 EEDDYPSEELLEDENAINAKRSKEKNPGN-QGRQFDVNLQVPDRAVLGTIHPDPEIEESK 779
E+ ++LL +E I++K + E++ + R+ + RA+ + E +E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEEL 1509
Query: 780 QETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTP 839
+ T+ +L +E ++K + G+ + + + +R L + + +K Q
Sbjct: 1510 ERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALETQ-----------MEEMKTQLE 1556
Query: 840 ELGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEK 885
EL + Q + L+ + + L G+ E +L D +N EK
Sbjct: 1557 ELEDELQATEDAKLRLE-----VNMQALKGQFERDLQARDEQNEEK 1597
Score = 43.1 bits (100), Expect = 0.003
Identities = 230/1258 (18%), Positives = 450/1258 (35%), Gaps = 214/1258 (17%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKH-HSHANSQA 217
E+ +Q E + +KER+ + E E+ S +E LQEQ + ++ A
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 218 NHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKT 277
++ E ++ +L+ E + + + + Q +D + L++E K
Sbjct: 918 VRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 278 KFGS-TADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDG 336
+ TA+A + E LV +D + + KE + +E +L +
Sbjct: 977 QLEKVTAEAKIKKLEDEILV----------MDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 337 EDMK--TPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGG 394
E K T K+ E ++ E +E+K + + +K + + + + I +
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085
Query: 395 EETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNN 454
E + + + + DD + + K + D +D
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED-----------L 1134
Query: 455 DKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGK 514
D E A + + + R + E L KTELED T+ S+ L + E+
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEAL---KTELED------TLDSTATQQELRAK--REQEV 1183
Query: 515 DTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGN-QMNDRKIQ 573
LK A D+ H ++ +K + + E + E ++A N N + ++
Sbjct: 1184 TVLKKALDEETRS------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 574 QESL---GSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP 630
+E+ G ++G + +A V + E R EL ++ V K QN+
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEV 1296
Query: 631 RFSSP---DEIDLPRELEDEVPILGRNLPWQQERDVAATASK-QMSEKIRLSEGEAK--E 684
+ + +L +V L L QE T K +S K+R E E +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 685 DSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSE-ELLEDENAINAKRSK 743
D LDEE +A Q E + SK + D+ S E LE+ K+
Sbjct: 1357 DQLDEEM---EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEE-----GKKRF 1404
Query: 744 EKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSETAAKGVNTGG 803
+K N +Q++ D+ +E++K LD
Sbjct: 1405 QKEIENLTQQYEEKAAAYDK-----------LEKTKNRLQQELDDLVVD----------- 1442
Query: 804 REPNTMVEKERPLAD--KKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKNDNPEEH 861
++ +R L +K QR F D + + + + + + D + + E+
Sbjct: 1443 ------LDNQRQLVSNLEKKQRKF------DQLLAEEKNISSKYAD-ERDRAEAEAREKE 1489
Query: 862 LKTSGLAGEPEGEL-SKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKR 920
K LA E L +KE+ E T K + E + +++ +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK----------------- 1532
Query: 921 EDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR 980
NVHELE S + Q E + +E++ D++ +
Sbjct: 1533 -----------------------NVHELEK-----SKRALETQMEEMKTQLEELEDEL-Q 1563
Query: 981 ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETAT 1040
A+E L + M + RDL + E+ L Y+ +E
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-----QLHEYETELEDERKQ 1618
Query: 1041 LVMAPPLEEGLGGAMEEMQPLHEDNFSREKTA-----ELNVQVPEEPTHL-DQRVIGDTH 1094
+A ++ L G +++++ + + A +L Q+ + L D R D
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1095 ASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQP----ETAAEEPASVTPLENAILLIY 1150
+ + K L+ + ++ A A KQ E AEE AS NA+
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1151 SFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQ 1210
+ ++ +A L ++++ + + DRV +
Sbjct: 1739 RRL----EARIAQLEEELEEEQG--------------------------NMEAMSDRVRK 1768
Query: 1211 VTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK 1270
T+Q +E+L + QK + Q+++ K ++ K + + K+K I
Sbjct: 1769 ATQQ--AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIA 1824
Query: 1271 TLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE L++ + + RE+ + L ++KK LK+++ E +
Sbjct: 1825 ALEAKIAQLEEQVE------QEAREKQAATKSLKQKDKK----LKEILLQVEDERKMAEQ 1874
Query: 1331 ALNEAKLSEEKVKS---ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE 1385
+A+ +VK + +EE+ R+ + +LQ+E+++ ++ + + ++ + +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Score = 42.7 bits (99), Expect = 0.003
Identities = 204/1154 (17%), Positives = 438/1154 (37%), Gaps = 166/1154 (14%)
Query: 329 PLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIF 388
PLL T E+ + ++K T + Q E + +L ++KN+L
Sbjct: 850 PLLQVTRQEEEMQAKEDELQK--TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 389 SIVTGGEETRDTMDLESSSSEE---------EKEDDDDALVPDSKQGKPQSATDYSDPDN 439
+ EE R + + EE E+E+D + ++ Q D +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 440 VDDG----LFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDK-----TEL--EDE 488
++ L + + K++ E + +R L++++ T L E+E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 489 NQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQ 548
+ +T + H + ++ + K ++ + + + L+G A + + + +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 549 ILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+ ++ E +AA +++D Q+ + + H + ++ ++ +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142
Query: 609 LSVEHQREELKEEL-VLKTQNQPRF-SSPDEIDLPRELEDEVPILGRNLPWQQERDVAAT 666
E Q+ +L EEL LKT+ + S+ + +L + E EV +L + L D
Sbjct: 1143 -KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL------DEETR 1195
Query: 667 ASKQMSEKIRLSEGEAKEDSLD--EEFFHHKAM--QGTEVGQTDQTDSTGGPAFLSKVEE 722
+ + +++R +A E+ + E+F KA + + + + D G L + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 723 DDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQET 782
+ ++ LE + + + K + + ++N +V E + T
Sbjct: 1256 EVEHKKKKLEAQ----VQELQSKCSDGERARAELNDKVHKLQ-----------NEVESVT 1300
Query: 783 SMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELG 842
M+ ++E + AK V + ++ ++ + L ++ + ++ + S ++ E
Sbjct: 1301 GMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR---QKLNVSTKLRQLEEERN 1353
Query: 843 EVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDD 902
+ D + N E H+ T + SK+ ++ + +G + E +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 903 SFHWTPHTSVEPGHSDKRE----------DLLIISSFFKEQ--QSLQRFQKYFNVHELEA 950
+ T + DK E D L++ + Q +L++ Q+ F+ +L A
Sbjct: 1410 NL--TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1465
Query: 951 LLQEMSSKL---------KSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTR---- 997
+ +SSK ++ ++E+ ++ + L++ A E L KML
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDL 1523
Query: 998 VAENRDLGMN-----------ENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPP 1046
V+ D+G N E + E L++++D + A E A L +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--------ATEDAKLRLEVN 1575
Query: 1047 LEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEK 1106
++ G ++Q E N EK +L Q+ E T L+ A + K E
Sbjct: 1576 MQALKGQFERDLQARDEQN--EEKRRQLQRQLHEYETELEDE--RKQRALAAAAKKKLEG 1631
Query: 1107 DLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPD 1166
DL +D + A A K E A ++ + + AT +
Sbjct: 1632 DL-------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 1167 DVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKE 1226
+ + L + + L A A + + K+ + + +S + + E
Sbjct: 1685 NEKKAKS---LEADLMQLQEDLAAAERAR---KQADLEKEELAEELASSLSGR-NALQDE 1737
Query: 1227 NTELVQKLSNYEQKIKESKKH-------VQETRKQNMILSDEAIKYKDKIKTLEKNQEIL 1279
L +++ E++++E + + V++ +Q LS+E + + E ++ L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 1280 DDTAKNLRVML-ESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLS 1338
+ K LR L E E K + I+ + I +L++ + A E Q A K
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQK 1854
Query: 1339 EEKVKSECHRVQEE--------------NARLKKKKEQLQQEIEDWSKLHA-------EL 1377
++K+K +V++E NAR+K+ K QL++ E+ +++A EL
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 1378 SEQIKSFEKSQKDL 1391
E +S E +++
Sbjct: 1915 DEATESNEAMGREV 1928
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 85.1 bits (209), Expect = 6e-16
Identities = 93/441 (21%), Positives = 193/441 (43%), Gaps = 34/441 (7%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
+ +I++K +K+ EL +S+ ++ + + + KQ L +E K ++
Sbjct: 1107 DDEIAQK-NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL--- 1162
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
++ LD TA + + E+E V + L E + +++++ +A E+ L
Sbjct: 1163 ---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLE 1392
+ K ++ + +++ENA L + L Q ++ +L Q++ + D E
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 1393 VALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIK 1452
A +D ++ L N + + + E+E + D + D E ++ + +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETR 1336
Query: 1453 QMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLE-----------DQVKKLEDDRNS 1501
Q ++VS T + +EE+ LQ +L + K NLE D KKL+D ++
Sbjct: 1337 QKLNVS---TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 1502 LQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVS 1561
++A LE+ K ++++E L + Y++K A K + +QE + + D +
Sbjct: 1394 VEA----LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-Q 1448
Query: 1562 AAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAAN 1621
++ +R+ +++ E + + ++ E +A E KA + RA+ EE EA
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEA-- 1505
Query: 1622 LRHKLLELTQKMAMLQEEPVI 1642
+ LE T KM + E ++
Sbjct: 1506 --KEELERTNKMLKAEMEDLV 1524
Score = 84.0 bits (206), Expect = 1e-15
Identities = 100/468 (21%), Positives = 207/468 (44%), Gaps = 64/468 (13%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++ ++ + + E ++ Q++ + E++++E +E +Q + L E + + KIK LE
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQL--EKVTAEAKIKKLE 991
Query: 1274 KNQEILDDTAKNL---RVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
++DD L R +LE N E K++ KLK + + S SE+++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK---NKHESMISELEV 1048
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE----K 1386
L + EEK + E L+K K +L+ + D+ + A+L QI + K
Sbjct: 1049 RLKK----EEKSRQE----------LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLE---------CESESEGQNKGGNDSDELANG 1437
+++L+ AL DD I N + ++ LE +SE +NK +L
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1151
Query: 1438 EVGGDRNEKMKNQIKQMMDVSRTQTAISVV-EEDLKLLQLKL-RASVSTKCNLEDQ---- 1491
G+ E +K +++ +D + TQ + E+++ +L+ L + S + +++
Sbjct: 1152 ---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 1492 ---VKKLEDDRNSLQAAKAGLEDECKTL-RQKVEILNEL--YQQKEMALQKKLSQEEYER 1545
V++L + + AKA L+ +TL ++ ++ EL Q + ++ K + E +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 1546 QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKA 1605
QE + + S + ++V + +E + L + E + K +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE----GKAIKLAKDVASLSSQL 1324
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQ 1653
+ + + EE R+ N+ KL +L ++ LQ++ + + M K N +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ--LDEEMEAKQNLE 1370
Score = 73.6 bits (179), Expect = 2e-12
Identities = 90/459 (19%), Positives = 213/459 (46%), Gaps = 56/459 (12%)
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILS-DEAIKYKDKI----KTLE 1273
K ++ E + K ++ E+ E++ +ET+ ++ + +EA++ K+++ K L+
Sbjct: 1459 KFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 1274 KNQEIL----DDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
E L DD KN+ + +S+R + +++ K +E+L+D + A+E ++++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLEELED--ELQATEDAKLR 1571
Query: 1330 IALNEAKLS---EEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEK 1386
+ +N L E +++ + +E+ +L+++ + + E+ED K A + K E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLECESES---EGQNKGGNDSDELANGEVGGDR 1443
KDLE+ D I I QL L+ + + E ++ + + A + +
Sbjct: 1632 DLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 1444 NEKMKNQIKQMM-DVSRTQTAISVVEEDLKLLQLKLRASVSTK--------------CNL 1488
+ ++ + Q+ D++ + A + + + L +L +S+S + L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 1489 EDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER 1548
E++ LE+++ +++A + K +Q ++ NEL ++ A + + ++++ ERQ +
Sbjct: 1749 EEE---LEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 1549 E-----HRLSAADE---KAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHE 1600
E H + A + K+ AA E K ++EE ++ + +++ + +KK E
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 1601 NWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
L+ + + K +A ++ +L +++ +EE
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 70.9 bits (172), Expect = 1e-11
Identities = 81/395 (20%), Positives = 167/395 (42%), Gaps = 28/395 (7%)
Query: 1212 TEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT 1271
T + + +++ ++ ++ + + E+ + + ++E + Q L DE +D
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1272 LEKNQEILDDT-AKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE N + L ++L+ E E+ + Q + E + +E + ++ A+ +++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD 1390
L + +L + ++ +L+ + + Q+E+ED E+ K EK K
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 1391 LEVALTHKDDNINALTNCITQLNL------LECESESEGQNKGGND-------------- 1430
LE L +++ A Q +L E S G+N ++
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 1431 -SDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN-L 1488
+E N E DR K Q +Q+ + T+ + + E + + + +K + +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1489 EDQVK-KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
E VK K + +L+A A LE++ + ++ + + +QK+ L++ L Q E ER+
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
E E+A VK KR++EE E+E Q+
Sbjct: 1872 AEQ----YKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Score = 60.8 bits (146), Expect = 1e-08
Identities = 99/491 (20%), Positives = 205/491 (41%), Gaps = 94/491 (19%)
Query: 1223 IMKENTELVQKLSNYE--QKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILD 1280
+++ N KL N++ + + K +Q TR++ + + E D+++ ++ Q+ +
Sbjct: 825 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE-----DELQKTKERQQKAE 879
Query: 1281 DTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEE 1340
+ K L E + Q + ++L+ E ++ +L +E E+++ L K E
Sbjct: 880 NELKEL----EQKHSQLTEEKNLLQEQLQAETELY-------AEAEEMRVRLAAKKQELE 928
Query: 1341 KVKSECH-RVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ----------- 1388
++ E R++EE R +QLQ E + ++ +L EQ++ E ++
Sbjct: 929 EILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 1389 ---KDLEVALTHKDDNINALT-------NCITQL--NLLECESESEGQNKGGNDSDELAN 1436
K LE + DD N L+ I+ L NL E E +++ K N + + +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 1437 G-EVGGDRNEKMKNQIKQM-------------------MDVSRTQTAISVVEEDLKLLQL 1476
EV + EK + +++++ ++ + ++ EE+L+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 1477 KLRASVSTKCN-------LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL------ 1523
+L ++ K N LE + L++D +S +AA+ E + + L +++E L
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 1524 --------NELYQQKEM---ALQKKLSQE----EYERQEREHRLSAADEKAVSAAEEVKT 1568
EL ++E L+K L +E E + QE + + A E+ E+ K
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
K +++ + L+K ++ + E K + E + E + + ++ E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 1629 LTQKMAMLQEE 1639
L K+ LQ E
Sbjct: 1285 LNDKVHKLQNE 1295
Score = 57.0 bits (136), Expect = 2e-07
Identities = 147/826 (17%), Positives = 316/826 (38%), Gaps = 116/826 (14%)
Query: 99 KDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAV 158
K L+QV + +EE+Q DE + E L LE +S T+ + +
Sbjct: 849 KPLLQVTRQ--EEEMQAKEDELQ-------KTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 159 EKTLQD---------------MEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQ 203
++ LQ K EL + +E + + +E + Q+
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 204 FTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDA 263
++ + Q E+ + E+ + L+D++ V + +NNK S
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER----------- 1008
Query: 264 YKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQE 323
KLL++ ++ DL T L ++E + +T L++ E + +E K++E++++
Sbjct: 1009 -KLLEERIS-DLTTN-------LAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1058
Query: 324 DFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTW 383
+ ++L D D + K Q + +E+++Q + + DD+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL---ARLDDE------ 1109
Query: 384 GDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSD--PDNVD 441
I + +LE S+ +++ D + + + + + + + ++
Sbjct: 1110 ------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 442 DGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHS 501
D L D T + E + + + E R E+ ++ + + +
Sbjct: 1164 DTL---DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 502 NNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGE-QILEGGSESESAQ 560
+ +K K TL+ D +L+ + + H++K E Q+ E S+ +
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 561 KAAGNQMNDR--KIQ----------QESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+A ++ND+ K+Q E+ G A + D + S + L+
Sbjct: 1280 RARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 609 LSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQER--DVAAT 666
L+V + +L+EE +N + +E++ + LE + L L +++ D A+T
Sbjct: 1339 LNVSTKLRQLEEE-----RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 667 ASKQMSEKIRL-SEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDS-----TGGPAFLSKV 720
K R E E +E+ + ++ T+ + D +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 721 EEDDYPSEELLEDENAINAKRSKEKNPGN-QGRQFDVNLQVPDRAVLGTIHPDPEIEESK 779
E+ ++LL +E I++K + E++ + R+ + RA+ + E +E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEEL 1509
Query: 780 QETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTP 839
+ T+ +L +E ++K + G+ + + + +R L + + +K Q
Sbjct: 1510 ERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALETQ-----------MEEMKTQLE 1556
Query: 840 ELGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEK 885
EL + Q + L+ + + L G+ E +L D +N EK
Sbjct: 1557 ELEDELQATEDAKLRLE-----VNMQALKGQFERDLQARDEQNEEK 1597
Score = 43.1 bits (100), Expect = 0.003
Identities = 230/1258 (18%), Positives = 450/1258 (35%), Gaps = 214/1258 (17%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKH-HSHANSQA 217
E+ +Q E + +KER+ + E E+ S +E LQEQ + ++ A
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 218 NHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKT 277
++ E ++ +L+ E + + + + Q +D + L++E K
Sbjct: 918 VRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 278 KFGS-TADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDG 336
+ TA+A + E LV +D + + KE + +E +L +
Sbjct: 977 QLEKVTAEAKIKKLEDEILV----------MDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 337 EDMK--TPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGG 394
E K T K+ E ++ E +E+K + + +K + + + + I +
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085
Query: 395 EETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNN 454
E + + + + DD + + K + D +D
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED-----------L 1134
Query: 455 DKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGK 514
D E A + + + R + E L KTELED T+ S+ L + E+
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEAL---KTELED------TLDSTATQQELRAK--REQEV 1183
Query: 515 DTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGN-QMNDRKIQ 573
LK A D+ H ++ +K + + E + E ++A N N + ++
Sbjct: 1184 TVLKKALDEETRS------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 574 QESL---GSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP 630
+E+ G ++G + +A V + E R EL ++ V K QN+
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEV 1296
Query: 631 RFSSP---DEIDLPRELEDEVPILGRNLPWQQERDVAATASK-QMSEKIRLSEGEAK--E 684
+ + +L +V L L QE T K +S K+R E E +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 685 DSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSE-ELLEDENAINAKRSK 743
D LDEE +A Q E + SK + D+ S E LE+ K+
Sbjct: 1357 DQLDEEM---EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEE-----GKKRF 1404
Query: 744 EKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSETAAKGVNTGG 803
+K N +Q++ D+ +E++K LD
Sbjct: 1405 QKEIENLTQQYEEKAAAYDK-----------LEKTKNRLQQELDDLVVD----------- 1442
Query: 804 REPNTMVEKERPLAD--KKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKNDNPEEH 861
++ +R L +K QR F D + + + + + + D + + E+
Sbjct: 1443 ------LDNQRQLVSNLEKKQRKF------DQLLAEEKNISSKYAD-ERDRAEAEAREKE 1489
Query: 862 LKTSGLAGEPEGEL-SKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKR 920
K LA E L +KE+ E T K + E + +++ +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK----------------- 1532
Query: 921 EDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR 980
NVHELE S + Q E + +E++ D++ +
Sbjct: 1533 -----------------------NVHELEK-----SKRALETQMEEMKTQLEELEDEL-Q 1563
Query: 981 ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETAT 1040
A+E L + M + RDL + E+ L Y+ +E
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-----QLHEYETELEDERKQ 1618
Query: 1041 LVMAPPLEEGLGGAMEEMQPLHEDNFSREKTA-----ELNVQVPEEPTHL-DQRVIGDTH 1094
+A ++ L G +++++ + + A +L Q+ + L D R D
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1095 ASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQP----ETAAEEPASVTPLENAILLIY 1150
+ + K L+ + ++ A A KQ E AEE AS NA+
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1151 SFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQ 1210
+ ++ +A L ++++ + + DRV +
Sbjct: 1739 RRL----EARIAQLEEELEEEQG--------------------------NMEAMSDRVRK 1768
Query: 1211 VTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK 1270
T+Q +E+L + QK + Q+++ K ++ K + + K+K I
Sbjct: 1769 ATQQ--AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIA 1824
Query: 1271 TLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE L++ + + RE+ + L ++KK LK+++ E +
Sbjct: 1825 ALEAKIAQLEEQVE------QEAREKQAATKSLKQKDKK----LKEILLQVEDERKMAEQ 1874
Query: 1331 ALNEAKLSEEKVKS---ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE 1385
+A+ +VK + +EE+ R+ + +LQ+E+++ ++ + + ++ + +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Score = 42.7 bits (99), Expect = 0.003
Identities = 204/1154 (17%), Positives = 438/1154 (37%), Gaps = 166/1154 (14%)
Query: 329 PLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIF 388
PLL T E+ + ++K T + Q E + +L ++KN+L
Sbjct: 850 PLLQVTRQEEEMQAKEDELQK--TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 389 SIVTGGEETRDTMDLESSSSEE---------EKEDDDDALVPDSKQGKPQSATDYSDPDN 439
+ EE R + + EE E+E+D + ++ Q D +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 440 VDDG----LFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDK-----TEL--EDE 488
++ L + + K++ E + +R L++++ T L E+E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 489 NQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQ 548
+ +T + H + ++ + K ++ + + + L+G A + + + +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 549 ILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+ ++ E +AA +++D Q+ + + H + ++ ++ +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142
Query: 609 LSVEHQREELKEEL-VLKTQNQPRF-SSPDEIDLPRELEDEVPILGRNLPWQQERDVAAT 666
E Q+ +L EEL LKT+ + S+ + +L + E EV +L + L D
Sbjct: 1143 -KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL------DEETR 1195
Query: 667 ASKQMSEKIRLSEGEAKEDSLD--EEFFHHKAM--QGTEVGQTDQTDSTGGPAFLSKVEE 722
+ + +++R +A E+ + E+F KA + + + + D G L + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 723 DDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQET 782
+ ++ LE + + + K + + ++N +V E + T
Sbjct: 1256 EVEHKKKKLEAQ----VQELQSKCSDGERARAELNDKVHKLQ-----------NEVESVT 1300
Query: 783 SMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELG 842
M+ ++E + AK V + ++ ++ + L ++ + ++ + S ++ E
Sbjct: 1301 GMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR---QKLNVSTKLRQLEEERN 1353
Query: 843 EVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDD 902
+ D + N E H+ T + SK+ ++ + +G + E +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 903 SFHWTPHTSVEPGHSDKRE----------DLLIISSFFKEQ--QSLQRFQKYFNVHELEA 950
+ T + DK E D L++ + Q +L++ Q+ F+ +L A
Sbjct: 1410 NL--TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1465
Query: 951 LLQEMSSKL---------KSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTR---- 997
+ +SSK ++ ++E+ ++ + L++ A E L KML
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDL 1523
Query: 998 VAENRDLGMN-----------ENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPP 1046
V+ D+G N E + E L++++D + A E A L +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--------ATEDAKLRLEVN 1575
Query: 1047 LEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEK 1106
++ G ++Q E N EK +L Q+ E T L+ A + K E
Sbjct: 1576 MQALKGQFERDLQARDEQN--EEKRRQLQRQLHEYETELEDE--RKQRALAAAAKKKLEG 1631
Query: 1107 DLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPD 1166
DL +D + A A K E A ++ + + AT +
Sbjct: 1632 DL-------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 1167 DVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKE 1226
+ + L + + L A A + + K+ + + +S + + E
Sbjct: 1685 NEKKAKS---LEADLMQLQEDLAAAERAR---KQADLEKEELAEELASSLSGR-NALQDE 1737
Query: 1227 NTELVQKLSNYEQKIKESKKH-------VQETRKQNMILSDEAIKYKDKIKTLEKNQEIL 1279
L +++ E++++E + + V++ +Q LS+E + + E ++ L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 1280 DDTAKNLRVML-ESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLS 1338
+ K LR L E E K + I+ + I +L++ + A E Q A K
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQK 1854
Query: 1339 EEKVKSECHRVQEE--------------NARLKKKKEQLQQEIEDWSKLHA-------EL 1377
++K+K +V++E NAR+K+ K QL++ E+ +++A EL
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 1378 SEQIKSFEKSQKDL 1391
E +S E +++
Sbjct: 1915 DEATESNEAMGREV 1928
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 85.1 bits (209), Expect = 6e-16
Identities = 93/441 (21%), Positives = 193/441 (43%), Gaps = 34/441 (7%)
Query: 1213 EQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTL 1272
+ +I++K +K+ EL +S+ ++ + + + KQ L +E K ++
Sbjct: 1100 DDEIAQK-NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL--- 1155
Query: 1273 EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIAL 1332
++ LD TA + + E+E V + L E + +++++ +A E+ L
Sbjct: 1156 ---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 1333 NEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLE 1392
+ K ++ + +++ENA L + L Q ++ +L Q++ + D E
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 1393 VALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIK 1452
A +D ++ L N + + + E+E + D + D E ++ + +
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETR 1329
Query: 1453 QMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLE-----------DQVKKLEDDRNS 1501
Q ++VS T + +EE+ LQ +L + K NLE D KKL+D ++
Sbjct: 1330 QKLNVS---TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 1502 LQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVS 1561
++A LE+ K ++++E L + Y++K A K + +QE + + D +
Sbjct: 1387 VEA----LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-Q 1441
Query: 1562 AAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAAN 1621
++ +R+ +++ E + + ++ E +A E KA + RA+ EE EA
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEA-- 1498
Query: 1622 LRHKLLELTQKMAMLQEEPVI 1642
+ LE T KM + E ++
Sbjct: 1499 --KEELERTNKMLKAEMEDLV 1517
Score = 84.0 bits (206), Expect = 1e-15
Identities = 100/468 (21%), Positives = 207/468 (44%), Gaps = 64/468 (13%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
++ ++ + + E ++ Q++ + E++++E +E +Q + L E + + KIK LE
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQL--EKVTAEAKIKKLE 984
Query: 1274 KNQEILDDTAKNL---RVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
++DD L R +LE N E K++ KLK + + S SE+++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK---NKHESMISELEV 1041
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE----K 1386
L + EEK + E L+K K +L+ + D+ + A+L QI + K
Sbjct: 1042 RLKK----EEKSRQE----------LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLE---------CESESEGQNKGGNDSDELANG 1437
+++L+ AL DD I N + ++ LE +SE +NK +L
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1144
Query: 1438 EVGGDRNEKMKNQIKQMMDVSRTQTAISVV-EEDLKLLQLKL-RASVSTKCNLEDQ---- 1491
G+ E +K +++ +D + TQ + E+++ +L+ L + S + +++
Sbjct: 1145 ---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 1492 ---VKKLEDDRNSLQAAKAGLEDECKTL-RQKVEILNEL--YQQKEMALQKKLSQEEYER 1545
V++L + + AKA L+ +TL ++ ++ EL Q + ++ K + E +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 1546 QEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKA 1605
QE + + S + ++V + +E + L + E + K +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE----GKAIKLAKDVASLSSQL 1317
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQ 1653
+ + + EE R+ N+ KL +L ++ LQ++ + + M K N +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ--LDEEMEAKQNLE 1363
Score = 73.6 bits (179), Expect = 2e-12
Identities = 90/459 (19%), Positives = 213/459 (46%), Gaps = 56/459 (12%)
Query: 1219 KLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILS-DEAIKYKDKI----KTLE 1273
K ++ E + K ++ E+ E++ +ET+ ++ + +EA++ K+++ K L+
Sbjct: 1452 KFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 1274 KNQEIL----DDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQ 1329
E L DD KN+ + +S+R + +++ K +E+L+D + A+E ++++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLEELED--ELQATEDAKLR 1564
Query: 1330 IALNEAKLS---EEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEK 1386
+ +N L E +++ + +E+ +L+++ + + E+ED K A + K E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1387 SQKDLEVALTHKDDNINALTNCITQLNLLECESES---EGQNKGGNDSDELANGEVGGDR 1443
KDLE+ D I I QL L+ + + E ++ + + A + +
Sbjct: 1625 DLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 1444 NEKMKNQIKQMM-DVSRTQTAISVVEEDLKLLQLKLRASVSTK--------------CNL 1488
+ ++ + Q+ D++ + A + + + L +L +S+S + L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 1489 EDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQER 1548
E++ LE+++ +++A + K +Q ++ NEL ++ A + + ++++ ERQ +
Sbjct: 1742 EEE---LEEEQGNMEAMSDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 1549 E-----HRLSAADE---KAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHE 1600
E H + A + K+ AA E K ++EE ++ + +++ + +KK E
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 1601 NWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEE 1639
L+ + + K +A ++ +L +++ +EE
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 70.9 bits (172), Expect = 1e-11
Identities = 81/395 (20%), Positives = 167/395 (42%), Gaps = 28/395 (7%)
Query: 1212 TEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT 1271
T + + +++ ++ ++ + + E+ + + ++E + Q L DE +D
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1272 LEKNQEILDDT-AKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE N + L ++L+ E E+ + Q + E + +E + ++ A+ +++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1331 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKD 1390
L + +L + ++ +L+ + + Q+E+ED E+ K EK K
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 1391 LEVALTHKDDNINALTNCITQLNL------LECESESEGQNKGGND-------------- 1430
LE L +++ A Q +L E S G+N ++
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 1431 -SDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCN-L 1488
+E N E DR K Q +Q+ + T+ + + E + + + +K + +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1489 EDQVK-KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
E VK K + +L+A A LE++ + ++ + + +QK+ L++ L Q E ER+
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
E E+A VK KR++EE E+E Q+
Sbjct: 1865 AEQ----YKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Score = 60.8 bits (146), Expect = 1e-08
Identities = 99/491 (20%), Positives = 205/491 (41%), Gaps = 94/491 (19%)
Query: 1223 IMKENTELVQKLSNYE--QKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILD 1280
+++ N KL N++ + + K +Q TR++ + + E D+++ ++ Q+ +
Sbjct: 818 VIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE-----DELQKTKERQQKAE 872
Query: 1281 DTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEE 1340
+ K L E + Q + ++L+ E ++ +L +E E+++ L K E
Sbjct: 873 NELKEL----EQKHSQLTEEKNLLQEQLQAETELY-------AEAEEMRVRLAAKKQELE 921
Query: 1341 KVKSECH-RVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQ----------- 1388
++ E R++EE R +QLQ E + ++ +L EQ++ E ++
Sbjct: 922 EILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 1389 ---KDLEVALTHKDDNINALT-------NCITQL--NLLECESESEGQNKGGNDSDELAN 1436
K LE + DD N L+ I+ L NL E E +++ K N + + +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 1437 G-EVGGDRNEKMKNQIKQM-------------------MDVSRTQTAISVVEEDLKLLQL 1476
EV + EK + +++++ ++ + ++ EE+L+
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 1477 KLRASVSTKCN-------LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL------ 1523
+L ++ K N LE + L++D +S +AA+ E + + L +++E L
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 1524 --------NELYQQKEM---ALQKKLSQE----EYERQEREHRLSAADEKAVSAAEEVKT 1568
EL ++E L+K L +E E + QE + + A E+ E+ K
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 1569 YKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLE 1628
K +++ + L+K ++ + E K + E + E + + ++ E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 1629 LTQKMAMLQEE 1639
L K+ LQ E
Sbjct: 1278 LNDKVHKLQNE 1288
Score = 57.0 bits (136), Expect = 2e-07
Identities = 147/826 (17%), Positives = 316/826 (38%), Gaps = 116/826 (14%)
Query: 99 KDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAV 158
K L+QV + +EE+Q DE + E L LE +S T+ + +
Sbjct: 842 KPLLQVTRQ--EEEMQAKEDELQ-------KTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 159 EKTLQD---------------MEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQ 203
++ LQ K EL + +E + + +E + Q+
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 204 FTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDA 263
++ + Q E+ + E+ + L+D++ V + +NNK S
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER----------- 1001
Query: 264 YKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQE 323
KLL++ ++ DL T L ++E + +T L++ E + +E K++E++++
Sbjct: 1002 -KLLEERIS-DLTTN-------LAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1051
Query: 324 DFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTW 383
+ ++L D D + K Q + +E+++Q + + DD+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL---ARLDDE------ 1102
Query: 384 GDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSD--PDNVD 441
I + +LE S+ +++ D + + + + + + + ++
Sbjct: 1103 ------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 442 DGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHS 501
D L D T + E + + + E R E+ ++ + + +
Sbjct: 1157 DTL---DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 502 NNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGE-QILEGGSESESAQ 560
+ +K K TL+ D +L+ + + H++K E Q+ E S+ +
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 561 KAAGNQMNDR--KIQ----------QESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+A ++ND+ K+Q E+ G A + D + S + L+
Sbjct: 1273 RARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 609 LSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQER--DVAAT 666
L+V + +L+EE +N + +E++ + LE + L L +++ D A+T
Sbjct: 1332 LNVSTKLRQLEEE-----RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 667 ASKQMSEKIRL-SEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDS-----TGGPAFLSKV 720
K R E E +E+ + ++ T+ + D +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 721 EEDDYPSEELLEDENAINAKRSKEKNPGN-QGRQFDVNLQVPDRAVLGTIHPDPEIEESK 779
E+ ++LL +E I++K + E++ + R+ + RA+ + E +E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEEL 1502
Query: 780 QETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTP 839
+ T+ +L +E ++K + G+ + + + +R L + + +K Q
Sbjct: 1503 ERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALETQ-----------MEEMKTQLE 1549
Query: 840 ELGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEK 885
EL + Q + L+ + + L G+ E +L D +N EK
Sbjct: 1550 ELEDELQATEDAKLRLE-----VNMQALKGQFERDLQARDEQNEEK 1590
Score = 43.1 bits (100), Expect = 0.003
Identities = 230/1258 (18%), Positives = 450/1258 (35%), Gaps = 214/1258 (17%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKH-HSHANSQA 217
E+ +Q E + +KER+ + E E+ S +E LQEQ + ++ A
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 218 NHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKT 277
++ E ++ +L+ E + + + + Q +D + L++E K
Sbjct: 911 VRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 278 KFGS-TADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDG 336
+ TA+A + E LV +D + + KE + +E +L +
Sbjct: 970 QLEKVTAEAKIKKLEDEILV----------MDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 337 EDMK--TPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGG 394
E K T K+ E ++ E +E+K + + +K + + + + I +
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1078
Query: 395 EETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNN 454
E + + + + DD + + K + D +D
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED-----------L 1127
Query: 455 DKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGK 514
D E A + + + R + E L KTELED T+ S+ L + E+
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEAL---KTELED------TLDSTATQQELRAK--REQEV 1176
Query: 515 DTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGN-QMNDRKIQ 573
LK A D+ H ++ +K + + E + E ++A N N + ++
Sbjct: 1177 TVLKKALDEETRS------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 574 QESL---GSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP 630
+E+ G ++G + +A V + E R EL ++ V K QN+
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEV 1289
Query: 631 RFSSP---DEIDLPRELEDEVPILGRNLPWQQERDVAATASK-QMSEKIRLSEGEAK--E 684
+ + +L +V L L QE T K +S K+R E E +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 685 DSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSE-ELLEDENAINAKRSK 743
D LDEE +A Q E + SK + D+ S E LE+ K+
Sbjct: 1350 DQLDEEM---EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEE-----GKKRF 1397
Query: 744 EKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSETAAKGVNTGG 803
+K N +Q++ D+ +E++K LD
Sbjct: 1398 QKEIENLTQQYEEKAAAYDK-----------LEKTKNRLQQELDDLVVD----------- 1435
Query: 804 REPNTMVEKERPLAD--KKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKNDNPEEH 861
++ +R L +K QR F D + + + + + + D + + E+
Sbjct: 1436 ------LDNQRQLVSNLEKKQRKF------DQLLAEEKNISSKYAD-ERDRAEAEAREKE 1482
Query: 862 LKTSGLAGEPEGEL-SKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEPGHSDKR 920
K LA E L +KE+ E T K + E + +++ +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK----------------- 1525
Query: 921 EDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR 980
NVHELE S + Q E + +E++ D++ +
Sbjct: 1526 -----------------------NVHELEK-----SKRALETQMEEMKTQLEELEDEL-Q 1556
Query: 981 ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETAT 1040
A+E L + M + RDL + E+ L Y+ +E
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-----QLHEYETELEDERKQ 1611
Query: 1041 LVMAPPLEEGLGGAMEEMQPLHEDNFSREKTA-----ELNVQVPEEPTHL-DQRVIGDTH 1094
+A ++ L G +++++ + + A +L Q+ + L D R D
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1095 ASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQP----ETAAEEPASVTPLENAILLIY 1150
+ + K L+ + ++ A A KQ E AEE AS NA+
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1151 SFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQ 1210
+ ++ +A L ++++ + + DRV +
Sbjct: 1732 RRL----EARIAQLEEELEEEQG--------------------------NMEAMSDRVRK 1761
Query: 1211 VTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK 1270
T+Q +E+L + QK + Q+++ K ++ K + + K+K I
Sbjct: 1762 ATQQ--AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIA 1817
Query: 1271 TLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1330
LE L++ + + RE+ + L ++KK LK+++ E +
Sbjct: 1818 ALEAKIAQLEEQVE------QEAREKQAATKSLKQKDKK----LKEILLQVEDERKMAEQ 1867
Query: 1331 ALNEAKLSEEKVKS---ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE 1385
+A+ +VK + +EE+ R+ + +LQ+E+++ ++ + + ++ + +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Score = 42.7 bits (99), Expect = 0.003
Identities = 204/1154 (17%), Positives = 438/1154 (37%), Gaps = 166/1154 (14%)
Query: 329 PLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIF 388
PLL T E+ + ++K T + Q E + +L ++KN+L
Sbjct: 843 PLLQVTRQEEEMQAKEDELQK--TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 389 SIVTGGEETRDTMDLESSSSEE---------EKEDDDDALVPDSKQGKPQSATDYSDPDN 439
+ EE R + + EE E+E+D + ++ Q D +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 440 VDDG----LFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDK-----TEL--EDE 488
++ L + + K++ E + +R L++++ T L E+E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 489 NQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQ 548
+ +T + H + ++ + K ++ + + + L+G A + + + +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 549 ILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHT 608
+ ++ E +AA +++D Q+ + + H + ++ ++ +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135
Query: 609 LSVEHQREELKEEL-VLKTQNQPRF-SSPDEIDLPRELEDEVPILGRNLPWQQERDVAAT 666
E Q+ +L EEL LKT+ + S+ + +L + E EV +L + L D
Sbjct: 1136 -KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL------DEETR 1188
Query: 667 ASKQMSEKIRLSEGEAKEDSLD--EEFFHHKAM--QGTEVGQTDQTDSTGGPAFLSKVEE 722
+ + +++R +A E+ + E+F KA + + + + D G L + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 723 DDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQET 782
+ ++ LE + + + K + + ++N +V E + T
Sbjct: 1249 EVEHKKKKLEAQ----VQELQSKCSDGERARAELNDKVHKLQ-----------NEVESVT 1293
Query: 783 SMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELG 842
M+ ++E + AK V + ++ ++ + L ++ + ++ + S ++ E
Sbjct: 1294 GMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQEETR---QKLNVSTKLRQLEEERN 1346
Query: 843 EVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDD 902
+ D + N E H+ T + SK+ ++ + +G + E +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 903 SFHWTPHTSVEPGHSDKRE----------DLLIISSFFKEQ--QSLQRFQKYFNVHELEA 950
+ T + DK E D L++ + Q +L++ Q+ F+ +L A
Sbjct: 1403 NL--TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1458
Query: 951 LLQEMSSKL---------KSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTR---- 997
+ +SSK ++ ++E+ ++ + L++ A E L KML
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDL 1516
Query: 998 VAENRDLGMN-----------ENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPP 1046
V+ D+G N E + E L++++D + A E A L +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--------ATEDAKLRLEVN 1568
Query: 1047 LEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEK 1106
++ G ++Q E N EK +L Q+ E T L+ A + K E
Sbjct: 1569 MQALKGQFERDLQARDEQN--EEKRRQLQRQLHEYETELEDE--RKQRALAAAAKKKLEG 1624
Query: 1107 DLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPD 1166
DL +D + A A K E A ++ + + AT +
Sbjct: 1625 DL-------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 1167 DVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKE 1226
+ + L + + L A A + + K+ + + +S + + E
Sbjct: 1678 NEKKAKS---LEADLMQLQEDLAAAERAR---KQADLEKEELAEELASSLSGR-NALQDE 1730
Query: 1227 NTELVQKLSNYEQKIKESKKH-------VQETRKQNMILSDEAIKYKDKIKTLEKNQEIL 1279
L +++ E++++E + + V++ +Q LS+E + + E ++ L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 1280 DDTAKNLRVML-ESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLS 1338
+ K LR L E E K + I+ + I +L++ + A E Q A K
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQK 1847
Query: 1339 EEKVKSECHRVQEE--------------NARLKKKKEQLQQEIEDWSKLHA-------EL 1377
++K+K +V++E NAR+K+ K QL++ E+ +++A EL
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 1378 SEQIKSFEKSQKDL 1391
E +S E +++
Sbjct: 1908 DEATESNEAMGREV 1921
>gi|14165274 golgi-associated microtubule-binding protein HOOK3 [Homo
sapiens]
Length = 718
Score = 85.1 bits (209), Expect = 6e-16
Identities = 107/467 (22%), Positives = 207/467 (44%), Gaps = 65/467 (13%)
Query: 1215 QISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQN---MILSDEAIKYKDKIKT 1271
Q+ +L+ + +E L +Y + +E +K + E R+QN L+DEA KD+I
Sbjct: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV 305
Query: 1272 L-----------------EKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKL 1314
L +K E L D + ++ +LE + ++N + E +
Sbjct: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVK-LLEEKNTMYMQNTVSLEEELRKANAA 364
Query: 1315 KDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLH 1374
+ + + E+Q L+E +K+ E R++E+ L+K+K++L+ E +
Sbjct: 365 RSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLK--- 421
Query: 1375 AELSEQIKSFEKSQKDLE----VALTHKDDNINALTNCIT-----QLNLLECESESEGQN 1425
E E+++ + + L + L ++ + + +T +L L+ E++ N
Sbjct: 422 -ETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLN 480
Query: 1426 KGGNDSDELANGEVGGDRNEKMKNQI--KQMMDVSRTQTAISVVEEDLKLLQ---LKLRA 1480
+ G+D++++A + D KN++ + + R S VEE K LQ K
Sbjct: 481 QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED 540
Query: 1481 SVSTKCNLEDQVKKLEDDRNSLQAAKAGLED---ECKTLRQKVEILNELYQQKEMALQKK 1537
SV K LE+ ++KL + N LQ +A +ED K+E L E ++KE + K
Sbjct: 541 SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEE--EMK 598
Query: 1538 LSQEEYER--QEREHRLSAADEKA-VSAAEEVKTYKRRIEE-------MEDELQKTE--- 1584
+E Y++ ++ + + D K AA E++ K +++E +E E +KT+
Sbjct: 599 QMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQR 658
Query: 1585 --------RSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLR 1623
++ N T KKA E+ L + + ++ +R+A + R
Sbjct: 659 EMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSR 705
Score = 53.1 bits (126), Expect = 2e-06
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 59/337 (17%)
Query: 1332 LNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQE-------------IED----WSKLH 1374
LNEA ++E++ CH + + A L+++K L E IED + H
Sbjct: 185 LNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH 244
Query: 1375 AELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDEL 1434
+L Q++ ++ LE A KDD + CE + ++ +DEL
Sbjct: 245 LQLQTQLEQLQEETFRLEAA---KDD------------YRIRCEELEKEISELRQQNDEL 289
Query: 1435 ANGEVGGDRNEKMKNQIKQMMDVSR-TQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVK 1493
D + +K++I DV R + +S +E ++ + KL +L QVK
Sbjct: 290 T---TLADEAQSLKDEI----DVLRHSSDKVSKLEGQVESYKKKL----EDLGDLRRQVK 338
Query: 1494 KLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLS 1553
LE+ LE+E + L E Y+++ + LQ +LS+E + + +
Sbjct: 339 LLEEKNTMYMQNTVSLEEELRKANAARSQL-ETYKRQVVELQNRLSEESKKADKLDFEYK 397
Query: 1554 AADEKAVSAAEE---VKTYKRRIEEMEDELQKTERSFKNQIATH--EKKAHENWLKARAA 1608
EK S +E ++T + ++E +EL+ + + Q+ T + + AA
Sbjct: 398 RLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQ-EGQLTTQGLMPLGSQESSDSLAA 456
Query: 1609 ERAIAEEKREAANLRH--KLLELTQ------KMAMLQ 1637
E E + + L+H K+L+L Q K+A+LQ
Sbjct: 457 EIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQ 493
Score = 50.4 bits (119), Expect = 2e-05
Identities = 79/357 (22%), Positives = 154/357 (43%), Gaps = 36/357 (10%)
Query: 1312 EKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEI---E 1368
E ++ ++ M S V A+ E E V + + + +LKK E+L + + E
Sbjct: 134 EYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE 193
Query: 1369 DWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGG 1428
+ ++ EL Q+ + ++ + L + +N ++ I N + Q +
Sbjct: 194 EIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ-SDSIEDPNSPAGRRHLQLQTQLE 252
Query: 1429 NDSDELANGEVGGD----RNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVST 1484
+E E D R E+++ +I ++ + T ++ + LK +
Sbjct: 253 QLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK-------DEIDV 305
Query: 1485 KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEIL---NELYQQKEMALQKKLSQ- 1540
+ D+V KLE +++ K LED LR++V++L N +Y Q ++L+++L +
Sbjct: 306 LRHSSDKVSKLE---GQVESYKKKLED-LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKA 361
Query: 1541 -------EEYERQ--EREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQ--KTER-SFK 1588
E Y+RQ E ++RLS +KA E K K +++ ++ E +TER S K
Sbjct: 362 NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLK 421
Query: 1589 NQIATHE-KKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVK 1644
I +A E L + ++E ++ E+ +K+ LQ E ++K
Sbjct: 422 ETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLK 478
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 85.1 bits (209), Expect = 6e-16
Identities = 111/494 (22%), Positives = 215/494 (43%), Gaps = 97/494 (19%)
Query: 1218 EKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQE 1277
+K+ + KEN +L KL + E KK ++E ++NM+L E
Sbjct: 378 DKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVL------------------E 419
Query: 1278 ILDDTAKNLRVMLESEREQNVKNQDLISENKKSI---------EKLKDVISMNASEFSEV 1328
I + N L E EQ KN DL ++KS ++ + N S S +
Sbjct: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTI 479
Query: 1329 QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAEL----SEQIKSF 1384
Q L +A L E+ +C +++EN +L KK E+LQ ++E + + +L E I+
Sbjct: 480 Q-GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREK 538
Query: 1385 EKSQKDLEVA----------LTHKDDNINALTNCITQLNLLECES---ESEGQNKGGNDS 1431
E+ Q D+E L + D++N + + + + E+ + E +NK + +
Sbjct: 539 EQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQT 598
Query: 1432 DELANGEVG-------------------GDRNEKMKNQIKQMMD--------VSRTQTAI 1464
ANG++ G+R EK++ +++++ + V+ +TA
Sbjct: 599 VTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETAT 658
Query: 1465 SVVE------EDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLR- 1517
VE + L+L LR S+ T N+ Q++ LE D L A L +T+R
Sbjct: 659 EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRF 718
Query: 1518 -----QKVEILNELYQQKEMALQK-----KLSQEEYERQEREHRLSAAD-----EKAVSA 1562
++E N+ ++++ L+K K ++ ER E ++ +A+ + S+
Sbjct: 719 TSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESS 778
Query: 1563 AEEVKTYKRRIEEMEDELQKTERSFKN-QIATHEKKAHENWLKARAAERAIAEEKREAAN 1621
+ + +T + + E+E E Q R + ++A + + E +A E+ +A+ +++
Sbjct: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEK--DRKALEQEVAQLEKDKKL 836
Query: 1622 LRHKLLELTQKMAM 1635
L + L Q++ +
Sbjct: 837 LEKEAKRLWQQVEL 850
Score = 67.8 bits (164), Expect = 1e-10
Identities = 103/437 (23%), Positives = 190/437 (43%), Gaps = 56/437 (12%)
Query: 1212 TEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKT 1271
T SE + + E + +L Q++++ + + +TR + D+ + K+K
Sbjct: 241 TSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHE----VDQLVLELQKVK- 295
Query: 1272 LEKNQEILDD--TAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNA--SEFSE 1327
++N ++ D +A+ R L+S RE+ + + L E + EKL DV A E E
Sbjct: 296 -QENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELRE 354
Query: 1328 VQIALNEAK-LSEEKVKS------ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ 1380
I L E K + EE++ + + H +++EN +LK K L+ + + K EL E+
Sbjct: 355 DNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEE 414
Query: 1381 IKSFEKSQK-----------DLEVALTHKDDNINALTNCITQLNLLECES------ESEG 1423
E +QK +LE + D + + + + +LN EC S E E
Sbjct: 415 NMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELN--ECASSRILKLEKEN 472
Query: 1424 QN-----KGGNDSD-ELANGEVGGDRNEKMKNQIKQMMDVSRTQTA--------ISVVEE 1469
Q+ +G D+ L + EK +Q+ + ++ +TQ + + E
Sbjct: 473 QSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSE 532
Query: 1470 DLKLLQLKLRASVST-KCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQ----KVEILN 1524
+L + +L++ + T K + Q+K LE +++ L A L + + + VE N
Sbjct: 533 ELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKEN 592
Query: 1525 ELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTE 1584
+ Q KLSQ E+E+++ L A EK AE+++ +R++E L +
Sbjct: 593 KALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKG-ERAEKLERELQRLQEENGRLARKV 651
Query: 1585 RSFKNQIATHEKKAHEN 1601
S + E HE+
Sbjct: 652 TSLETATEKVEALEHES 668
Score = 64.7 bits (156), Expect = 8e-10
Identities = 104/484 (21%), Positives = 206/484 (42%), Gaps = 70/484 (14%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYE---QKIKESKKHVQETRKQNMILS---DEAIKYKD 1267
+++ +L+ + +EN L +K+++ E +K++ + Q + +N L D
Sbjct: 631 EKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSL 690
Query: 1268 KIKTLEKNQEILDDTAKNLRVM--------------------LESEREQNVKNQDLISEN 1307
+++ LE++ + LD LR + LE E+E+ KN DL+
Sbjct: 691 QLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKAL 750
Query: 1308 KKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQ--- 1364
K E+L+ ++E +Q +L + + ++SE ++ E L++ E L+
Sbjct: 751 GKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLAN 810
Query: 1365 QEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNIN----ALTNCITQLNLLECESE 1420
++E K L +++ EK +K LE + L + +L+ +E ES
Sbjct: 811 AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESR 870
Query: 1421 SEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQT----AISVVEEDLKLLQL 1476
+ + ELA D K+K K D+++ T ++ + EDL L +L
Sbjct: 871 ALDK--------ELARCR---DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKL 919
Query: 1477 KLRASVSTKCNLEDQVKKLEDDRN-SLQAAKAGLEDECKTLRQKVEILNELYQQKEMAL- 1534
K + S L +++K+ +R LQ +G + + K L + NE + +A+
Sbjct: 920 KSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGR----NESALKTTLAMK 975
Query: 1535 QKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKN----Q 1590
++K+ E + +E+ ++ + + S + +K + + + E Q + SFK+
Sbjct: 976 EEKIVLLEAQMEEK----ASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKT 1031
Query: 1591 IATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKP 1650
A+H+ K E W E E ++ + +EL + A LQ E ++K
Sbjct: 1032 AASHQGK--EAWGPGH------KEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHL 1083
Query: 1651 NTQN 1654
TQN
Sbjct: 1084 ETQN 1087
Score = 57.4 bits (137), Expect = 1e-07
Identities = 114/606 (18%), Positives = 237/606 (39%), Gaps = 94/606 (15%)
Query: 1199 RTVLVVKDRVYQVTEQQISEKLKT---------IMKENTELVQKLSNYEQKIKESKKH-- 1247
+T L +K+ + E Q+ EK ++K+ E +++ Q ++ S KH
Sbjct: 969 KTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPA 1028
Query: 1248 ----VQETRKQ-----NMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNV 1298
K+ + + E ++ KD+ LE+N L + L+ L+ QNV
Sbjct: 1029 GKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNV 1088
Query: 1299 KNQDLISENKKSIEKLKDVISMNASEFSEVQI-----ALNEAKLSEEKVKSECHRV--QE 1351
I +K L++ + ++ +++Q+ + A L+ + + H +
Sbjct: 1089 TFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKET 1148
Query: 1352 ENARLKKKKEQLQ-------QEIEDWSKLHAELSEQIKSFEKSQKDLE-----VALTHKD 1399
EN L++++EQL Q+ E LH S + ++ + L+ + L HK+
Sbjct: 1149 ENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKE 1208
Query: 1400 ------DNINALTNCITQLNLLECESESEGQNKGGN----DSDELANGEVGGDRNEKMKN 1449
D + + +L E E+ Q + N ++ GE+ DR + +
Sbjct: 1209 LGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGEL--DRVNFLHH 1266
Query: 1450 QIKQMMD-----VSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQA 1504
Q+K + +T+++ + +L Q + ++ + KL++ L
Sbjct: 1267 QLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSR 1326
Query: 1505 AKAGLEDECKTLRQKVEILNELYQQKEMALQKKL-SQEEYERQEREHRLSAADEKAVSAA 1563
K LE+E L ++++L+ QQ +M L++ + ++E+Y +++++ +
Sbjct: 1327 LKGNLEEENHHLLSQIQLLS---QQNQMLLEQNMENKEQYHEEQKQY---------IDKL 1374
Query: 1564 EEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLR 1623
++ +K ++EE K +K +KK H W+ A+A + I + K+E + R
Sbjct: 1375 NALRRHKEKLEE------KIMDQYKFYDPPPKKKNH--WIGAKALVKLI-KPKKEGSRER 1425
Query: 1624 HKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTV 1683
K + + +P +P PL +P G C+
Sbjct: 1426 LKSTVDSPPWQLESSDPA------------SPAASQPLRSQAENPDTPALGSNCAE---- 1469
Query: 1684 EPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSSSRG 1743
E S D+ G L S + + + PS+ GS T + +++
Sbjct: 1470 ERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAP 1529
Query: 1744 SSPTRV 1749
S+ T +
Sbjct: 1530 SNSTPI 1535
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 84.7 bits (208), Expect = 8e-16
Identities = 91/437 (20%), Positives = 190/437 (43%), Gaps = 60/437 (13%)
Query: 1221 KTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIK----TLEKNQ 1276
+T+ +EN L +++SN +++E K++ E K ++ +E + + ++ LE+N+
Sbjct: 1508 ETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 1277 -EILDDTAKNLRVMLESEREQNVKNQDLISENKK---SIEKLKDVISMNASEFSEV---- 1328
+IL + L E ER+ + K++++ + +K +I+ L+ + A EV
Sbjct: 1568 SKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Query: 1329 ---QIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFE 1385
+ LNE +L + + +L+ + + LQ +++D ++L+++L EQ+ E
Sbjct: 1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAE 1687
Query: 1386 KSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDE-----LANGEVG 1440
+ N + Q L + S E +G S+E +
Sbjct: 1688 RR-------------------NSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLF 1728
Query: 1441 GDRNEKMKNQIKQM-MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDR 1499
+N + +Q K++ DV+R Q V ++ + + K + + NL +++KK +D
Sbjct: 1729 YTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTI 1788
Query: 1500 NSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKA 1559
L+ + +E L+++ L E Q M +K++ + E +E E L ++
Sbjct: 1789 AHLERTRENMEQTITDLQKR---LAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRS 1845
Query: 1560 VSA-----------------AEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENW 1602
A AEE K R++ D+LQ +++K Q+ E +A++
Sbjct: 1846 AEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYL 1905
Query: 1603 LKARAAERAIAEEKREA 1619
K + + + E K A
Sbjct: 1906 SKYKKQQHELNEVKERA 1922
Score = 71.6 bits (174), Expect = 7e-12
Identities = 90/450 (20%), Positives = 200/450 (44%), Gaps = 44/450 (9%)
Query: 1213 EQQISEKL-KTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIK----YKD 1267
EQ++ +L +T+ K N E+VQ YE + + + +++ +K+ I EA +
Sbjct: 1362 EQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANA 1421
Query: 1268 KIKTLEKNQ--------EILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVIS 1319
+ +LE+ + + L D K +++Q +++ +++ K+ E+ + ++
Sbjct: 1422 RNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQ-LQSGKALADWKQKHEESQALLD 1480
Query: 1320 MNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSE 1379
+ E + L + K + E+ ++ EN L+++ L ++ + +K E+ +
Sbjct: 1481 ASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEK 1540
Query: 1380 QIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGE- 1438
K E+ + +++V L + + + I L E+++E + K +E+ N
Sbjct: 1541 VKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRR 1600
Query: 1439 ----VGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKL-----RASVSTKC--N 1487
+ ++ K ++V+R + +EEDL ++L+L + S +TK
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEVTRLK---KKMEEDLNEMELQLSCANRQVSEATKSLGQ 1657
Query: 1488 LEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQE 1547
L+ Q+K L+ + + L+++ ++ +L Q E+ + L E+ E
Sbjct: 1658 LQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLL-----QSELEDLRSLQ----EQTE 1708
Query: 1548 REHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARA 1607
R RLS +E+ + A E + + + + + +K E +A +K+A E + +
Sbjct: 1709 RGRRLS--EEELLEATERINLFYTQNTSLLSQKKKLEA----DVARMQKEAEEVVQECQN 1762
Query: 1608 AERAIAEEKREAANLRHKLLELTQKMAMLQ 1637
AE + EAANL +L + +A L+
Sbjct: 1763 AEEKAKKAAIEAANLSEELKKKQDTIAHLE 1792
Score = 68.9 bits (167), Expect = 4e-11
Identities = 94/451 (20%), Positives = 189/451 (41%), Gaps = 41/451 (9%)
Query: 1214 QQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLE 1273
+++SE+++ + N+EL + E + E KK + + + E + K+K L
Sbjct: 932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLT 991
Query: 1274 KNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALN 1333
+ E L++ L + +E + + D + ++ + L + E++ AL
Sbjct: 992 EEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALE 1051
Query: 1334 EAKLSEEKVKSECHRVQEENARLKKKK----EQLQQEI-EDWSKLHAELSEQIKSFEKSQ 1388
+ + + + E H++ E N +L ++ E Q+ + E+ K ELS Q+ S +++
Sbjct: 1052 QERKARMNCERELHKL-EGNLKLNRESMENLESSQRHLAEELRKKELELS-QMNSKVENE 1109
Query: 1389 KDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMK 1448
K L L + TQ+ L+ + E+E + + + + D NE+++
Sbjct: 1110 KGLVAQLQ------KTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLE 1163
Query: 1449 ----NQIKQMMDVSRTQTAISVVEEDLKLLQLKLR-ASVSTKCNLEDQVKKLEDDRNSLQ 1503
+ + Q+ + +T + D++ L S S K D + +LE +LQ
Sbjct: 1164 EVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQ 1223
Query: 1504 AAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEE----YERQEREHRLSAADEKA 1559
K LE + L+ +V+ +L + E + K + E+ YE ER H +A +K
Sbjct: 1224 QVKQKLEKDKSDLQLEVD---DLLTRVEQMTRAKANAEKLCTLYE--ERLHEATAKLDKV 1278
Query: 1560 VSAAEEVKTYK-----------RRIEEME---DELQKTERSFKNQIATHEKKAHENWLKA 1605
A ++ K RR+EE E ++L + + +F QI + +
Sbjct: 1279 TQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQ 1338
Query: 1606 RAAERAIAEEKREAANLRHKLLELTQKMAML 1636
A A+ + +R+ LR + E + A L
Sbjct: 1339 SALAHALQKAQRDCDLLREQYEEEQEVKAEL 1369
Score = 57.0 bits (136), Expect = 2e-07
Identities = 84/482 (17%), Positives = 209/482 (43%), Gaps = 74/482 (15%)
Query: 1205 KDRVYQVTEQ--QISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEA 1262
++R+++ T + ++++ + + T+L + + ++++E + + + ++ + +
Sbjct: 1265 EERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQI 1324
Query: 1263 IKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKL-------- 1314
+ +++ K+Q L + + + REQ + Q++ +E +++ K+
Sbjct: 1325 EDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWR 1384
Query: 1315 -----------------KDVISMNASEFSEVQIALNEAKLSEEKVK-----------SEC 1346
K +++ E +E N S E+ + S+
Sbjct: 1385 MKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL 1444
Query: 1347 HRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNINALT 1406
+V+ ARL +K+ Q + + DW + H E + + SQK+++ T N
Sbjct: 1445 GKVRSAAARLDQKQLQSGKALADWKQKHEESQALL---DASQKEVQALSTELLKLKNTYE 1501
Query: 1407 NCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQ-----MMDVSRTQ 1461
I L E+++ Q + N ++++ G EK+K I++ + + T+
Sbjct: 1502 ESIVGQETLRRENKNL-QEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETE 1560
Query: 1462 TAISVVEEDLKLLQLK-LRASVSTKCNLEDQVKKLEDDRN----SLQAAKAGLEDECKTL 1516
A+ E + QL+ L A + L ++ +++E+ R ++ + ++ L+ E K+
Sbjct: 1561 GALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKS- 1619
Query: 1517 RQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEM 1576
++E+ L+KK+ E + E E +LS A+ + A + + + +I+++
Sbjct: 1620 --RIEVTR---------LKKKM---EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDL 1665
Query: 1577 E---DELQKTERSFKNQIATHEKKAHENWLKARAAE-RAIAEEKREAANL-RHKLLELTQ 1631
+ D+ + K Q+A E++ + L++ + R++ E+ L +LLE T+
Sbjct: 1666 QMQLDDSTQLNSDLKEQVAVAERR--NSLLQSELEDLRSLQEQTERGRRLSEEELLEATE 1723
Query: 1632 KM 1633
++
Sbjct: 1724 RI 1725
Score = 41.2 bits (95), Expect = 0.010
Identities = 37/181 (20%), Positives = 86/181 (47%), Gaps = 15/181 (8%)
Query: 1471 LKLLQLKLRASVSTK----CNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNEL 1526
L L+Q +RA ++ K L ++K L + + AGL++EC L++ +E +E
Sbjct: 823 LILIQWNIRAFMAVKNWPWMRLFFKIKPLVKS-SEVGEEVAGLKEECAQLQKALE-KSEF 880
Query: 1527 YQQKEMALQKKLSQEE----YERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQK 1582
+++ A Q L+QE+ + Q + L+ +E+ + + R++E+ + +++
Sbjct: 881 QREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEE 940
Query: 1583 TERSFKNQIATHEKKAHENWLKARAA----ERAIAEEKREAANLRHKLLELTQKMAMLQE 1638
E +++ +K + + + E + + ++E HK+ LT+++ L E
Sbjct: 941 -EEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNE 999
Query: 1639 E 1639
+
Sbjct: 1000 D 1000
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 83.2 bits (204), Expect = 2e-15
Identities = 84/455 (18%), Positives = 217/455 (47%), Gaps = 56/455 (12%)
Query: 1203 VVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEA 1262
V ++ ++ QQ EK+ ++ E +K+ E+KI+E ++ ++E +++ M +E
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE-QEEKMRRQEEM 343
Query: 1263 IKYKDKIKTLEKNQEILDDTAKNLRVMLES--EREQNVKNQDLISENKKSIEKLKDVISM 1320
+ K+ + + + +E++ + + +R E E+E+ ++ Q+ + K+ EK+++
Sbjct: 344 MWEKE--EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE--EKIRE---- 395
Query: 1321 NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ 1380
L E +EK++ + + QEE ++++++++ +QE + W + E+
Sbjct: 396 -----------LEEKMHEQEKIREQEEKRQEEE-KIREQEKRQEQEAKMWRQ-----EEK 438
Query: 1381 IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG 1440
I+ E+ ++ E + +++ I+ + + E + + Q + +++ E
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIH-------EQEKIREEEKRQEQEEMWRQEEKIHEQEEI 491
Query: 1441 GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLED--- 1497
+ EKM Q ++ + + + + EE ++ + K+R E+++++ E+
Sbjct: 492 WRQKEKMHEQEEK---IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548
Query: 1498 ------DRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHR 1551
++ + + E E K RQ+ +I + ++K ++K+ ++E +RQE+E +
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ--EEKVWRQEEKIREQEEKRQEQEEK 606
Query: 1552 LSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQ---IATHEKKAHENWLKARAA 1608
+ +EK E+++ + +I E E+++++ E + Q + E+K E K +
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666
Query: 1609 ERAIAEEKREAANLRHKLLELTQKM----AMLQEE 1639
E + ++ + K+ E +K+ M+QE+
Sbjct: 667 EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQ 701
Score = 82.8 bits (203), Expect = 3e-15
Identities = 83/439 (18%), Positives = 207/439 (47%), Gaps = 64/439 (14%)
Query: 1214 QQISEKLKTIMKENT-------ELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYK 1266
Q +S KL+ ++EN + +K+ E+KI+E ++ +QE ++ + ++ K +
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK---IREQEEKIR 331
Query: 1267 DKIKTLEKNQEILDDTAKNLRVMLES--EREQNVKNQD-LISENKKSIEKLKDVISMNAS 1323
++ + + + +E++ + + +R E E+E+ ++ Q+ ++ E ++ + + ++++
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 391
Query: 1324 EFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKS 1383
+ E++ ++E +EK++ + + QEE ++++++++ +QE + W + E+I+
Sbjct: 392 KIRELEEKMHE----QEKIREQEEKRQEEE-KIREQEKRQEQEAKMWRQ-----EEKIRE 441
Query: 1384 FEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDR 1443
E+ ++ E + +++ I+ Q + E E E Q + +++ E +
Sbjct: 442 QEEKIREQEKKMWRQEEKIHE------QEKIREEEKRQE-QEEMWRQEEKIHEQEEIWRQ 494
Query: 1444 NEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQ 1503
EKM Q ++ + + + + EE ++ + K+R E+++++ E
Sbjct: 495 KEKMHEQEEK---IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE------- 544
Query: 1504 AAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAA 1563
E+++++E +++ EE +RQE+E ++ +EK
Sbjct: 545 ---------------------EMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE 583
Query: 1564 EEVKTYKRRIEEMEDELQKTERSF---KNQIATHEKKAHENWLKARAAERAIAEEKREAA 1620
E+V + +I E E++ Q+ E + +I E+K E K R E I E++
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 1621 NLRHKLLELTQKMAMLQEE 1639
K+ E +KM +E+
Sbjct: 644 EQEEKMGEQEEKMCEQEEK 662
Score = 65.9 bits (159), Expect = 4e-10
Identities = 79/405 (19%), Positives = 185/405 (45%), Gaps = 29/405 (7%)
Query: 1229 ELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKNLRV 1288
EL Q LS + K++ ++++E K+ LS E Y++ I ++E+ + AK L+
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLEL--YRNTIT----DEELKEKNAK-LQE 228
Query: 1289 MLESEREQNVKNQDLISENKKSIEKLKDVISMN---------ASEFSEVQIALNEAKLSE 1339
L+ + + Q + E K+ +E+ K ++ E V L +A++ E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL-QAQVEE 287
Query: 1340 EKVKSECHRVQEENA-RLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHK 1398
++ + ++ QEE R ++K ++ +++I++ + E E+I+ E+ + E + K
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK 347
Query: 1399 DDNINALTNCITQLNLLECESESEGQNKGGNDSDELANG--EVGGDRNEKMKNQIKQMMD 1456
++ + + E E + Q + + +E E+ ++ EK++ ++M +
Sbjct: 348 EEKMRRQEEM-----MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 402
Query: 1457 VSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTL 1516
+ + +E+ K+ + + R K +++ + ++++ Q K ++E
Sbjct: 403 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 1517 RQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEM 1576
++K+ + +Q+EM Q++ E+ E ++ ++ +EK E+V + +I E
Sbjct: 463 QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQ 522
Query: 1577 EDELQKTERSFKNQIATHEKKAHENWL---KARAAERAIAEEKRE 1618
E+++++ E Q ++ E W K E+ EEKR+
Sbjct: 523 EEKIREQEEKMWRQ-EEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Score = 55.1 bits (131), Expect = 7e-07
Identities = 65/379 (17%), Positives = 163/379 (43%), Gaps = 40/379 (10%)
Query: 1301 QDLIS---ENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLK 1357
+DLIS ++ K +L+ +S A++ + + E + + E +R + LK
Sbjct: 161 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220
Query: 1358 KKKEQLQQEIEDWSKLHAELSEQIKSFEKS---------QKDLEVALTH---KDDNINAL 1405
+K +LQ++++ +E+ +K ++ Q+ L+ H + +++A
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 1406 TNCITQLNLLECESESEGQNKGGNDSDELANGEVG-GDRNEKMKNQ---IKQMMDVSRTQ 1461
+ N L + + K +++ E ++ EK++ Q I++ + R Q
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 1462 TAISVVEEDLKLLQLKLRASVSTKCNLEDQVK-KLEDDRNSLQAAKAGLEDECKTLRQKV 1520
+ +E+ Q ++ K ++++ + E+ + E++ + L +K+
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Query: 1521 EILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDEL 1580
++ +Q+E +++ +E+ +RQE+E ++ +EK E+++ ++++ E+++
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 1581 ------------QKTERSFKNQIATHE--------KKAHENWLKARAAERAIAEEKREAA 1620
Q+ E ++ + HE +K HE K R E + ++ +
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 1621 NLRHKLLELTQKMAMLQEE 1639
K+ E +KM +E+
Sbjct: 521 EQEEKIREQEEKMWRQEEK 539
Score = 51.6 bits (122), Expect = 7e-06
Identities = 64/323 (19%), Positives = 137/323 (42%), Gaps = 28/323 (8%)
Query: 1332 LNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDL 1391
+N E CH ++E + +E L++E+E +++H I+ + +L
Sbjct: 90 INNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELE--AQVHT-----IRILTCQKTEL 142
Query: 1392 EVALTHKDDNINALTNCITQL-NLLECESESEGQNKGGNDSDELANGEVGGDR--NEKMK 1448
++AL + + L L + L + G+ + + +A + DR E K
Sbjct: 143 QMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSA--VATQKKKADRYIEELTK 200
Query: 1449 NQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLED---------DR 1499
+ +++ R ++E LQ KL+ S K ++ VK+L+ +
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ 260
Query: 1500 NSLQAAKAGLEDECKTLRQKVEIL---NELYQQKEMALQKKLSQEEYERQEREHRLSAAD 1556
LQA L E +++ K++ NEL+ + ++K+ ++E + QE E ++ +
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 1557 EKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEK 1616
EK E+++ + ++ E+ + + E + Q E+ E K R E + E++
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ----EEMMWEKEEKMRRQEEMMWEKE 376
Query: 1617 REAANLRHKLLELTQKMAMLQEE 1639
+ + E +K+ L+E+
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEK 399
Score = 42.4 bits (98), Expect = 0.004
Identities = 34/218 (15%), Positives = 104/218 (47%), Gaps = 26/218 (11%)
Query: 1197 LWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQN- 1255
+WR ++++ ++ EQ+ EK+ +E +++ E+K+ E +K +E ++Q
Sbjct: 512 VWRQEEKIREQEEKIREQE--EKMWR-QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ 568
Query: 1256 ---MILSDEAIK--------YKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLI 1304
M +E I+ ++KI+ E+ ++ ++ + + E+ + ++ I
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKI 628
Query: 1305 SENKKSIEKLKDVISMNASEFSEVQIALNEAK-----------LSEEKVKSECHRVQEEN 1353
E ++ I + +++ + E + + E + EEK++ + +++E+
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 1354 ARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDL 1391
++++++E +Q++ E + ++ EQ + ++ ++ +
Sbjct: 689 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 726
Score = 33.1 bits (74), Expect = 2.7
Identities = 21/111 (18%), Positives = 48/111 (43%), Gaps = 2/111 (1%)
Query: 153 DSEKAVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQ-KHHS 211
+ E+ +++ + + + E +E+E + E E + E E +QEQ T +
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Query: 212 HANSQANHAQGEQASFESFEEMLQD-KLKVPESENNKTSNSSQVSNEQDKI 261
Q + ++ EEM+Q+ + K+ E E ++ +++K+
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 726
Score = 32.0 bits (71), Expect = 5.9
Identities = 23/106 (21%), Positives = 42/106 (39%), Gaps = 8/106 (7%)
Query: 159 EKTLQDMEKNPELSKEREPEPEPV---EANSEESDSVFSENTEDLQEQFTTQKHHSHANS 215
EK + EK E ++R+ + E + E E + E E ++EQ +
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 216 QANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKI 261
+ GEQ E+M + + K+ E E ++ ++ KI
Sbjct: 644 EQEEKMGEQE-----EKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.128 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,263,800
Number of Sequences: 37866
Number of extensions: 4862728
Number of successful extensions: 44948
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 460
Number of HSP's successfully gapped in prelim test: 2235
Number of HSP's that attempted gapping in prelim test: 21663
Number of HSP's gapped (non-prelim): 14781
length of query: 1907
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1790
effective length of database: 13,817,196
effective search space: 24732780840
effective search space used: 24732780840
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.