Search of human proteins with 28610149

Search of human proteins with 28610149

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
         (329 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...   683   0.0  
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...   674   0.0  
gi|27437045 colony stimulating factor 3 receptor isoform d precu...   124   1e-28
gi|24496783 colony stimulating factor 3 receptor isoform c precu...   124   1e-28
gi|27437042 colony stimulating factor 3 receptor isoform b precu...   124   1e-28
gi|4503081 colony stimulating factor 3 receptor isoform a precur...   124   1e-28
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]             122   4e-28
gi|115430248 gp130-like monocyte receptor [Homo sapiens]               99   7e-21
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]    91   2e-18
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s...    84   2e-16
gi|189083786 leukemia inhibitory factor receptor precursor [Homo...    84   2e-16
gi|24430212 interleukin 23 receptor precursor [Homo sapiens]           74   2e-13
gi|4506107 prolactin receptor [Homo sapiens]                           73   3e-13
gi|22212918 ciliary neurotrophic factor receptor preproprotein [...    65   1e-10
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H...    65   1e-10
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                   62   7e-10
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                   62   7e-10
gi|40254464 leptin receptor isoform 1 [Homo sapiens]                   62   7e-10
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi...    59   6e-09
gi|4557040 oncostatin M receptor [Homo sapiens]                        59   8e-09
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi...    58   1e-08
gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap...    58   1e-08
gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo sapi...    57   3e-08
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ...    53   3e-07
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [...    53   3e-07
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H...    53   3e-07
gi|4758282 ephrin receptor EphA7 [Homo sapiens]                        53   4e-07
gi|145312251 EPH receptor A6 isoform a [Homo sapiens]                  50   4e-06
gi|222352127 sidekick 2 [Homo sapiens]                                 48   1e-05
gi|110349719 titin isoform N2-A [Homo sapiens]                         47   2e-05

>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score =  683 bits (1763), Expect = 0.0
 Identities = 329/329 (100%), Positives = 329/329 (100%)

Query: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
           MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60

Query: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
           NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120

Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
           ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180

Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240

Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
           KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300

Query: 301 CMKEDGKGYWSDWSEEASGITYEDNIASF 329
           CMKEDGKGYWSDWSEEASGITYEDNIASF
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYEDNIASF 329


>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score =  674 bits (1739), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
           MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60

Query: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
           NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120

Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
           ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180

Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240

Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
           KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300

Query: 301 CMKEDGKGYWSDWSEEASGITYED 324
           CMKEDGKGYWSDWSEEASGITYED
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYED 324


>gi|27437045 colony stimulating factor 3 receptor isoform d
           precursor [Homo sapiens]
          Length = 783

 Score =  124 bits (311), Expect = 1e-28
 Identities = 96/325 (29%), Positives = 152/325 (46%), Gaps = 28/325 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 EL----SSILKLTWTNPSIKSVIILKYNIQYR-TKDASTWSQIPPEDTASTRSSFTVQDL 289
           E     +  L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWS 314
            P T Y  +IRC++    G+WSDWS
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|24496783 colony stimulating factor 3 receptor isoform c
           precursor [Homo sapiens]
          Length = 863

 Score =  124 bits (311), Expect = 1e-28
 Identities = 96/325 (29%), Positives = 152/325 (46%), Gaps = 28/325 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 EL----SSILKLTWTNPSIKSVIILKYNIQYR-TKDASTWSQIPPEDTASTRSSFTVQDL 289
           E     +  L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWS 314
            P T Y  +IRC++    G+WSDWS
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|27437042 colony stimulating factor 3 receptor isoform b
           precursor [Homo sapiens]
          Length = 769

 Score =  124 bits (311), Expect = 1e-28
 Identities = 96/325 (29%), Positives = 152/325 (46%), Gaps = 28/325 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 EL----SSILKLTWTNPSIKSVIILKYNIQYR-TKDASTWSQIPPEDTASTRSSFTVQDL 289
           E     +  L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWS 314
            P T Y  +IRC++    G+WSDWS
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
           [Homo sapiens]
          Length = 836

 Score =  124 bits (311), Expect = 1e-28
 Identities = 96/325 (29%), Positives = 152/325 (46%), Gaps = 28/325 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 EL----SSILKLTWTNPSIKSVIILKYNIQYR-TKDASTWSQIPPEDTASTRSSFTVQDL 289
           E     +  L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWS 314
            P T Y  +IRC++    G+WSDWS
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWS 322


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score =  122 bits (306), Expect = 4e-28
 Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90
           ISP+ P + + S+  A C +     D     A  + W  N   +P E   ++N +  ++ 
Sbjct: 43  ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99

Query: 91  FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
             ++     +   N++   +    + G  +  GLPPEKP N+SC     K + C W  G 
Sbjct: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159

Query: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206
             ET L TN++LK +   +   +   +  T  P SC +      F   E+WVEA N LG 
Sbjct: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219

Query: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264
             SD +  D +  V  +PP ++ V     L   L + W + P++K  +   KY I+YR +
Sbjct: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279

Query: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319
           D+  W  +   D  S ++S  +  LKP T Y  ++RC           G WS+WS   + 
Sbjct: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336

Query: 320 IT 321
            T
Sbjct: 337 ST 338


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score = 98.6 bits (244), Expect = 7e-21
 Identities = 62/207 (29%), Positives = 107/207 (51%), Gaps = 11/207 (5%)

Query: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWA-THKFADCKAKRDTP---TS 181
           P KP+N+SC+    K + C W  G+ET   T +T+K  +A   K  +C     T     S
Sbjct: 54  PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112

Query: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239
           C+     +    N  + VEAEN  G + S H+ +  +  + K  PP    V     +  +
Sbjct: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171

Query: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297
           +++ W  P +  V   LKY +++RT ++++W ++   ++      ++ +  L+PFTEYV 
Sbjct: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231

Query: 298 RIRCMKEDGKGYWSDWSEEASGITYED 324
            +RC  ++ K +WSDWS+E  G+T E+
Sbjct: 232 ALRCAVKESK-FWSDWSQEKMGMTEEE 257


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 74/270 (27%), Positives = 115/270 (42%), Gaps = 27/270 (10%)

Query: 72  FTIPKEQYTIINRTASSVTFTDIASLNIQLT----------CNILTFGQLEQNVYGITII 121
           F   +    I+ +    + F    SLN Q+T          C +      E  + G  I 
Sbjct: 60  FHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIF 119

Query: 122 SGLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKR---- 176
            G+ PE+P+NLSCI   E   + C W+ GR+THL T +TL+     +     + K     
Sbjct: 120 VGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCD 179

Query: 177 --DTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
             D   + T +       N    V A N+LG  +S    F  +  V+P PP ++ +   +
Sbjct: 180 YLDFGINLTPESPES---NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQK 236

Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
              S   L W +  +    +L   ++YR  ++  W+ +   +    +    + DLKPFTE
Sbjct: 237 ASVSRCTLYWRDEGL----VLLNRLRYRPSNSRLWNMV---NVTKAKGRHDLLDLKPFTE 289

Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYED 324
           Y F+I       KG WSDWSE     T E+
Sbjct: 290 YEFQISSKLHLYKGSWSDWSESLRAQTPEE 319


>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 81/304 (26%), Positives = 132/304 (43%), Gaps = 36/304 (11%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313

Query: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355

Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413

Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470

Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528

Query: 320 ITYE 323
           +T E
Sbjct: 529 LTTE 532


>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 81/304 (26%), Positives = 132/304 (43%), Gaps = 36/304 (11%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313

Query: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355

Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413

Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470

Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528

Query: 320 ITYE 323
           +T E
Sbjct: 529 LTTE 532


>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
          Length = 629

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 61/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%)

Query: 78  QYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQN-VYGITIISGLPPEKPKNLSCIV 136
           Q T IN+T + + + +    +  + C        ++  + G  I SG PP+ P  ++C++
Sbjct: 76  QITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVI 135

Query: 137 NE-GKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIE 195
            E    M C W+ G+ T+++T + +       K  + + ++   TS  ++ ST      +
Sbjct: 136 YEYSGNMTCTWNAGKLTYIDTKYVVHV-----KSLETEEEQQYLTSSYINISTDSLQGGK 190

Query: 196 ---VWVEAENALGKVTSD--HINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
              VWV+A NALG   S    I+ D +             IN+    +I  + W + +  
Sbjct: 191 KYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTI--IYWDSQT-- 246

Query: 251 SVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW 310
           ++  +   ++Y+     TW+ +   DT  T    +   L+P  +YVF++RC +E GK YW
Sbjct: 247 TIEKVSCEMRYKATTNQTWN-VKEFDTNFTYVQQSEFYLEPNIKYVFQVRC-QETGKRYW 304

Query: 311 SDWS 314
             WS
Sbjct: 305 QPWS 308


>gi|4506107 prolactin receptor [Homo sapiens]
          Length = 622

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 21/203 (10%)

Query: 124 LPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTL----KSEWATHKFADCKAKRDTP 179
           LPP KP+   C     +   C W  G +  L TN++L    + E   H+  D       P
Sbjct: 26  LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYIT--GGP 83

Query: 180 TSCTV--DYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLS--VINSEE 235
            SC     Y++++   I + V A N +G   SD +  D  Y V+P+PP  L+  V   E+
Sbjct: 84  NSCHFGKQYTSMWRTYI-MMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPED 142

Query: 236 LSSILKLTWTNPSIKSV----IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
               L + W+ P++  +      L Y I+ + + A+ W        A  ++ F +  L P
Sbjct: 143 RKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE----IHFAGQQTEFKILSLHP 198

Query: 292 FTEYVFRIRCMKEDGKGYWSDWS 314
             +Y+ ++RC  +   GYWS WS
Sbjct: 199 GQKYLVQVRCKPD--HGYWSAWS 219


>gi|22212918 ciliary neurotrophic factor receptor preproprotein
           [Homo sapiens]
          Length = 372

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 13/200 (6%)

Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
           GLPP +P  LSC  N   K   C W     T++   F +     + K   C+        
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163

Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           C + Y  ++  +  +V +   NALG   +  I FD    VKP+PP N+           L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222

Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
           ++TW  PS         LK+ ++YR      W  +   D     ++ T+ D     EY+ 
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSD----GTAHTITDAYAGKEYII 278

Query: 298 RIRCMKEDGKGYWSDWSEEA 317
           ++   K++  G WSDWS  A
Sbjct: 279 QV-AAKDNEIGTWSDWSVAA 297


>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
           sapiens]
          Length = 372

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 13/200 (6%)

Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
           GLPP +P  LSC  N   K   C W     T++   F +     + K   C+        
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163

Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           C + Y  ++  +  +V +   NALG   +  I FD    VKP+PP N+           L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222

Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
           ++TW  PS         LK+ ++YR      W  +   D     ++ T+ D     EY+ 
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSD----GTAHTITDAYAGKEYII 278

Query: 298 RIRCMKEDGKGYWSDWSEEA 317
           ++   K++  G WSDWS  A
Sbjct: 279 QV-AAKDNEIGTWSDWSVAA 297


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 72/309 (23%), Positives = 122/309 (39%), Gaps = 40/309 (12%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEA 317
           YWS+WS  A
Sbjct: 621 YWSNWSNPA 629



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 72/309 (23%), Positives = 122/309 (39%), Gaps = 40/309 (12%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEA 317
           YWS+WS  A
Sbjct: 621 YWSNWSNPA 629



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 72/309 (23%), Positives = 122/309 (39%), Gaps = 40/309 (12%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEA 317
           YWS+WS  A
Sbjct: 621 YWSNWSNPA 629



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
           sapiens]
          Length = 1005

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 58/210 (27%), Positives = 85/210 (40%), Gaps = 20/210 (9%)

Query: 125 PPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFADC-KAKRDT 178
           PP  P NL   VN G  +  EW      GGR          +  WA  +   C    R  
Sbjct: 328 PPSAPVNLISSVN-GTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFV 386

Query: 179 PTSCTVDYSTVYFVNI------EVWVEAENALGKVTSDHINFDPVYKVKPNP--PHNLSV 230
           P   ++  +++   N+        W+EA N +  ++ +      V  +  N   P  + V
Sbjct: 387 PQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRA-AVVNITTNQAAPSQVVV 445

Query: 231 INSEELSSI-LKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDL 289
           I  E      + L W  P   + IIL+Y I+Y  KD    S    +   +TR+  TV  L
Sbjct: 446 IRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLK-AVTTRA--TVSGL 502

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
           KP T YVF++R     G G +S   E  +G
Sbjct: 503 KPGTRYVFQVRARTSAGCGRFSQAMEVETG 532


>gi|4557040 oncostatin M receptor [Homo sapiens]
          Length = 979

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 18/212 (8%)

Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHL------ETNFTLKS 162
           G + + + GI +      E+PK+ SC   + K + C WD G +T L        ++TL  
Sbjct: 220 GNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFE 279

Query: 163 EWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
            ++  K   C  K       T D    Y       + AEN L K  S +I F+  ++V  
Sbjct: 280 SFSGEKKL-CTHKNWCNWQITQDSQETY----NFTLIAENYLRK-RSVNILFNLTHRVYL 333

Query: 223 NPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
             P +++  N    ++I  +TW   SI++       I+   +       +    +     
Sbjct: 334 MNPFSVNFENVNATNAI--MTWKVHSIRNNFTYLCQIELHGEGKMMQYNV----SIKVNG 387

Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
            + + +L+P TEY+ R+RC        WS+WS
Sbjct: 388 EYFLSELEPATEYMARVRCADASHFWKWSEWS 419


>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
           sapiens]
          Length = 468

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 55/225 (24%), Positives = 100/225 (44%), Gaps = 29/225 (12%)

Query: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175
           + ++  +PPE+P+ LSC        + CEW G R T    + T K+     KF +  A+ 
Sbjct: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160

Query: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
                         SC +      S+ Y V++ V     +++G   S    F     ++P
Sbjct: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216

Query: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
           +PP N++V         L +TW +P     S   L++ ++YR + + T++    +D    
Sbjct: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273

Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDN 325
           +    + D      +V ++R  +E G+G WS+WS EA G  + ++
Sbjct: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES 318


>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
           sapiens]
          Length = 365

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 55/225 (24%), Positives = 100/225 (44%), Gaps = 29/225 (12%)

Query: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175
           + ++  +PPE+P+ LSC        + CEW G R T    + T K+     KF +  A+ 
Sbjct: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160

Query: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
                         SC +      S+ Y V++ V     +++G   S    F     ++P
Sbjct: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216

Query: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
           +PP N++V         L +TW +P     S   L++ ++YR + + T++    +D    
Sbjct: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273

Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDN 325
           +    + D      +V ++R  +E G+G WS+WS EA G  + ++
Sbjct: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES 318


>gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo
           sapiens]
          Length = 427

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 76/313 (24%), Positives = 118/313 (37%), Gaps = 37/313 (11%)

Query: 34  ESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTD 93
           + PV  L  +   +C +          ++N  +W  +HF   K+   I   T  S+    
Sbjct: 32  QPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFG-DKQDKKIAPETRRSIEVPL 90

Query: 94  IASLNIQLTCNILTFGQLEQNVYGITIIS---GLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
              + +Q+     T    + ++     IS   G P      L CI +    M+C W  GR
Sbjct: 91  NERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGR 150

Query: 151 ETHLETNFTLKSEW--ATHKFADCK--AKRDTPTSCTVDYSTV---YFVNIEVWVEAENA 203
            T  +TN+TL   W  +  K   C+   +      C+ D + V    F    V +  ++ 
Sbjct: 151 NTSPDTNYTL-YYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDN 209

Query: 204 LGKVTSDHINFDPVYKVKPNPPH--NLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
            GK+           +VKP+PPH  NLS  N +     L + W NP       L Y ++ 
Sbjct: 210 AGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDD-----LYVQWENPQNFISRCLFYEVEV 264

Query: 262 RTKDASTWS---------QIPP-EDTASTRSSFTVQDLKPFTEYVFRIR------CMKED 305
                 T +         + P  E      S F V  + P T    RIR      C ++D
Sbjct: 265 NNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDD 324

Query: 306 GKGYWSDWSEEAS 318
               WS+WS+E S
Sbjct: 325 --KLWSNWSQEMS 335


>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
           [Homo sapiens]
          Length = 422

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 21/216 (9%)

Query: 118 ITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRD 177
           +T+  G PP +P  +SC   + +   C W   + + L T +       T   AD + +  
Sbjct: 105 VTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSP 163

Query: 178 T--PTSCTVD---------YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPH 226
           +  P  C  D         +   ++    + V   N LG  T   ++      ++P+PP 
Sbjct: 164 STGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTR-LLDVSLQSILRPDPPQ 222

Query: 227 NLSVINSEELSSILKLTWTNPS---IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
            L V +       L+ +WT P+    +   +LK+ +QYR      WS + P         
Sbjct: 223 GLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE---- 278

Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
             + D      +  R+        G WS WS EA G
Sbjct: 279 -VITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313


>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
           [Homo sapiens]
          Length = 390

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 21/216 (9%)

Query: 118 ITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRD 177
           +T+  G PP +P  +SC   + +   C W   + + L T +       T   AD + +  
Sbjct: 105 VTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSP 163

Query: 178 T--PTSCTVD---------YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPH 226
           +  P  C  D         +   ++    + V   N LG  T   ++      ++P+PP 
Sbjct: 164 STGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTR-LLDVSLQSILRPDPPQ 222

Query: 227 NLSVINSEELSSILKLTWTNPS---IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
            L V +       L+ +WT P+    +   +LK+ +QYR      WS + P         
Sbjct: 223 GLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE---- 278

Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
             + D      +  R+        G WS WS EA G
Sbjct: 279 -VITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313


>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
           sapiens]
          Length = 422

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 21/216 (9%)

Query: 118 ITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRD 177
           +T+  G PP +P  +SC   + +   C W   + + L T +       T   AD + +  
Sbjct: 105 VTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSP 163

Query: 178 T--PTSCTVD---------YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPH 226
           +  P  C  D         +   ++    + V   N LG  T   ++      ++P+PP 
Sbjct: 164 STGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTR-LLDVSLQSILRPDPPQ 222

Query: 227 NLSVINSEELSSILKLTWTNPS---IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
            L V +       L+ +WT P+    +   +LK+ +QYR      WS + P         
Sbjct: 223 GLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE---- 278

Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
             + D      +  R+        G WS WS EA G
Sbjct: 279 -VITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313


>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
          Length = 998

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 57/225 (25%), Positives = 90/225 (40%), Gaps = 27/225 (12%)

Query: 125 PPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFADCKAK---R 176
           PP  P+NL   +N+   +  EW     +GGR          +  W   +   C +     
Sbjct: 331 PPSAPQNLIFNINQ-TTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYM 389

Query: 177 DTPTSCTVDYSTVY----FVNIEVWVEAENALGKVTSDHINFDPVYKV--KPNPPHNLSV 230
              T    +Y TV       N    VEA N +  ++     F  V     +  P     V
Sbjct: 390 PQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGV 449

Query: 231 INSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAS--TWSQIPPEDTASTRSSFTVQD 288
           +    L   ++L+W  P   + +I +Y I+Y  KD    T+S +  + T+++     + +
Sbjct: 450 MKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSAS-----INN 504

Query: 289 LKPFTEYVFRIRCMKEDGKGYWSD-----WSEEASGITYEDNIAS 328
           LKP T YVF+IR     G G +S        EEA+G  +E    S
Sbjct: 505 LKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVS 549


>gi|145312251 EPH receptor A6 isoform a [Homo sapiens]
          Length = 1130

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 55/217 (25%), Positives = 86/217 (39%), Gaps = 18/217 (8%)

Query: 125 PPEKPKNLSCIVNEGKKMRCEWD-----GGRETHLETNFTLKSEWATHKFADCKAK-RDT 178
           PP  P+N+   +NE   +  EW      GGR+    +    K    T +  DC    R  
Sbjct: 425 PPSAPRNVVFNINE-TALILEWSPPSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFI 483

Query: 179 P------TSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPV-YKVKPNPPHNLSVI 231
           P       +  +    V  VN    +EA N + +++     F  +      + P  + V+
Sbjct: 484 PRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDAPSLIGVV 543

Query: 232 NSEELS-SILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLK 290
             +  S + + L+W  P+  +  IL Y I+Y  K+     Q+    T S   S  +  LK
Sbjct: 544 RKDWASQNSIALSWQAPAFSNGAILDYEIKYYEKEHE---QLTYSSTRSKAPSVIITGLK 600

Query: 291 PFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDNIA 327
           P T+YVF IR     G   +S   E  +G    D  A
Sbjct: 601 PATKYVFHIRVRTATGYSGYSQKFEFETGDETSDMAA 637


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 36/125 (28%), Positives = 54/125 (43%), Gaps = 12/125 (9%)

Query: 197  WVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK 256
            W EA  AL   T          + +P PP    V   +  +  + L+W   S     +  
Sbjct: 1383 WGEAAEALVVTTEK--------RDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRY 1434

Query: 257  YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEE 316
            Y IQ R   +  W+ +     +   SSF V  LKPFT Y FR++   + G    S++SEE
Sbjct: 1435 YTIQTRELPSGRWA-LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGD---SEFSEE 1490

Query: 317  ASGIT 321
            +  +T
Sbjct: 1491 SESLT 1495



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 52/225 (23%), Positives = 82/225 (36%), Gaps = 21/225 (9%)

Query: 104  NILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWD-------GGRETHLET 156
            N +  G   Q V G T  S +P   P N+S +      M   W         G     + 
Sbjct: 1179 NAIGSGPWSQTVVGRTRES-VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237

Query: 157  NFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINF-D 215
             +  K      +F   +         T       +V  EV V A   +G  +  H    +
Sbjct: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLT---GLGKYVLYEVQVLAFTRIGDGSPSHPPILE 1294

Query: 216  PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275
                  P PP  + ++  E  ++ ++L W  P+  + IIL Y I +R  + +T +    E
Sbjct: 1295 RTLDDVPGPP--MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL-NTTTANTATVE 1351

Query: 276  DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI 320
              A +   +T   LKP + Y+FRI      G      W E A  +
Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRITAQTRKG------WGEAAEAL 1390



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 3/95 (3%)

Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
           P H ++ +++ E  +I  LTWT P   +  +++Y ++    +A     +   D  +T  S
Sbjct: 593 PEHPVATLSTVERRAI-NLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT--S 649

Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEAS 318
            TV+ L P   Y FR+  + + GKG +S  +E  S
Sbjct: 650 VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVS 684



 Score = 32.7 bits (73), Expect = 0.46
 Identities = 47/212 (22%), Positives = 79/212 (37%), Gaps = 17/212 (8%)

Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHK 168
           GQ  ++   +++    P   P+N+       + +  +W    E+H   N  LK     + 
Sbjct: 674 GQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESH--QNGILKGYIIRYC 731

Query: 169 FADC------KAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK-VTSDHINFDPVYKVK 221
            A        K   D   +  +    + + N E+ V A N+ G  V S  +    +  V 
Sbjct: 732 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791

Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNI---QYRTKDASTWSQIPPED 276
             PP N+    +   S+ ++ TW  PS + +  I   Y +   +   ++  T     P  
Sbjct: 792 TVPPGNVHAEATN--STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNF 849

Query: 277 TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
             S    F V  LK FTEY   + C    G G
Sbjct: 850 QDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDG 880



 Score = 32.3 bits (72), Expect = 0.60
 Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 11/105 (10%)

Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNI---QYRTKDASTWSQIPPEDTA 278
           P P  +LS   SE L + LK++W  P  K+ I+  Y I   +Y   +      +P     
Sbjct: 895 PGPVGHLSF--SEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLP----- 947

Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYE 323
           +    + V  L   T Y   +  M   G+G  S  S  +SG+  E
Sbjct: 948 NVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA-STISSGVPPE 991



 Score = 32.3 bits (72), Expect = 0.60
 Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 10/91 (10%)

Query: 222  PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS----QIPPEDT 277
            P PP    ++     SS + + W++       I +Y I+ R  D   W      IP E +
Sbjct: 1825 PGPPGVPIIVR---YSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881

Query: 278  ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
            + T   F++  LKP   Y FR+  + + G G
Sbjct: 1882 SYT---FSMDILKPGVSYDFRVIAVNDYGFG 1909



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 17/96 (17%)

Query: 225  PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDA--STWSQIPPE 275
            P N+S+  + E S  L L W        N + +SV    Y I+Y   D    T S +  +
Sbjct: 1100 PANVSLRTASETS--LWLRWMPLPEMEYNGNPESV---GYKIKYSRSDGHGKTLSHVVQD 1154

Query: 276  DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
                    +T++DL+ +TEY  +++     G G WS
Sbjct: 1155 ---RVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS 1187



 Score = 28.5 bits (62), Expect = 8.6
 Identities = 30/108 (27%), Positives = 39/108 (36%), Gaps = 2/108 (1%)

Query: 194  IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI 253
            IEV        G+V++  I+   V    P PP NL + N    S  L+         S+ 
Sbjct: 966  IEVAAMTSKGQGQVSASTIS-SGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSIS 1024

Query: 254  ILKYNIQYRTK-DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
                  Q     +   W  I          S  V DL PFT Y FR+R
Sbjct: 1025 RWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMR 1072


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 70/264 (26%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 70    NHFTIPKEQYTIINRTASSVTFTDIASLNIQLTC----NILTFGQLEQNVYGI--TIISG 123
             +H+ I K + + ++ T  S   T++ +LN ++T     N   F  +  N YGI   + SG
Sbjct: 24835 SHYIIEKRETSRLSWTQVS---TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESG 24891

Query: 124   --------LPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFA 170
                      PP  P            M   W     DGG  T +E     K +    ++ 
Sbjct: 24892 PVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGG--TEIEGYILEKRDKEGVRWT 24949

Query: 171   DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENA--LGKVTSDHINF---DPVYKVKPNPP 225
              C  K  T     V   T    + E  V AENA  +G+ +   + +   D +Y   P PP
Sbjct: 24950 KCNKKTLTDLRLRVTGLTEGH-SYEFRVAAENAAGVGEPSEPSVFYRACDALYP--PGPP 25006

Query: 226   HNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTASTRSSF 284
              N  V ++   S  + L W+ P       +K Y ++ +   A  W+   P  T      F
Sbjct: 25007 SNPKVTDTSRSS--VSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP-TGLQGKQF 25063

Query: 285   TVQDLKPFTEYVFRIRCMKEDGKG 308
             TV  LK  TEY FRI  +  +G G
Sbjct: 25064 TVTKLKENTEYNFRICAINSEGVG 25087



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 66/264 (25%), Positives = 98/264 (37%), Gaps = 43/264 (16%)

Query: 77    EQYTIINRTASSVTFTDIASLNIQLTC---------NILTFGQLEQNVYGI--------- 118
             + Y +  R  S + +T++AS  +Q+T          N   F  +  N YG+         
Sbjct: 21588 DHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPV 21646

Query: 119   -TIISGLPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTL-KSEWATHKFAD 171
               +    PP+ PKN          M   W     DGG E     N+ + + + A  ++  
Sbjct: 21647 LAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI---INYIVERRDKAGQRWIK 21703

Query: 172   CKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV-----KPNPPH 226
             C  K  T     V   T      E  + AENA G   S      P YK      KP PP 
Sbjct: 21704 CNKKTLTDLRYKVSGLTEGH-EYEFRIMAENAAG--ISAPSPTSPFYKACDTVFKPGPPG 21760

Query: 227   NLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQI-PPEDTASTRSSF 284
             N  V+++   S  + + W  P       I  Y ++    +   W  + PP    +T  S+
Sbjct: 21761 NPRVLDTSRSS--ISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT--SY 21816

Query: 285   TVQDLKPFTEYVFRIRCMKEDGKG 308
             T+  L    EY  RI  M  +G G
Sbjct: 21817 TITGLTENQEYKIRIYAMNSEGLG 21840



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 4/116 (3%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELS-SILKLTWTNPSIKSVI 253
             E  V AENA G   +  I+     +   NPP   +V+   + S + + L W+ P     +
Sbjct: 28224 EFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGM 28283

Query: 254   -ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              I+ Y I+    D   W ++  E    TR  +TV DL+   EY FR+  +   GKG
Sbjct: 28284 EIIGYIIEMCKADLGDWHKVNAEACVKTR--YTVTDLQAGEEYKFRVSAINGAGKG 28337



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 28/92 (30%), Positives = 43/92 (46%), Gaps = 6/92 (6%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAST 280
             P P  +L V  S+   +   ++W  P       +  Y ++ R  D  TWS + PE     
Sbjct: 18699 PGPVSDLKV--SDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPE---VK 18753

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312
             ++SF V +L P  EY FR+  + E G G  +D
Sbjct: 18754 KTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTD 18785



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 11/121 (9%)

Query: 198   VEAENALGKVT-SDHINF----DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
             V A NA G    S+  NF    +P Y   P PP    V+++ + S  + L WT P     
Sbjct: 29315 VTAVNAAGNSEPSEASNFISCREPSYT--PGPPSAPRVVDTTKHS--ISLAWTKPMYDGG 29370

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
               I+ Y ++ + KD   W ++    T    + FTV DLK   +Y FR+  +   G   +S
Sbjct: 29371 TDIVGYVLEMQEKDTDQWYRVHTNATIRN-TEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 29429

Query: 312   D 312
             +
Sbjct: 29430 E 29430



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 23/195 (11%)

Query: 125   PPEKPKNLSCIVNEGKK-MRCEW-----DGGRET---HLETNFTLKSEWATHKFADCKAK 175
             PPE P N   +++  K  +   W     DGG      ++E   T   +W  H        
Sbjct: 30328 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTT 30387

Query: 176   RDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV---KPNPPHNLSVIN 232
               T T    D         +  + A+N +G   +   +   V K    KP+ P  L +++
Sbjct: 30388 MYTVTGLVPD------AEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILS 30441

Query: 233   SEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
               + S  + L W  P       IL Y ++YR    S W +   E     +  FT+  L  
Sbjct: 30442 ISKDS--VTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQ--FTIGGLLE 30497

Query: 292   FTEYVFRIRCMKEDG 306
              TEY FR+    E G
Sbjct: 30498 ATEYEFRVFAENETG 30512



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 42/167 (25%), Positives = 69/167 (41%), Gaps = 20/167 (11%)

Query: 164   WATHKFAD-CKAKRDTP---TSCTVDYSTVYFVNIE------VWVEAENALGKVTSDHIN 213
             W T+   + C+AK        S  +  +T   VN+         V A+N  G   SD + 
Sbjct: 30754 WITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFG--ISDPLE 30811

Query: 214   FDPVYKVKPNPPHNLSVINSEELSSILK----LTWTNP-SIKSVIILKYNIQYRTKDAST 268
                V  +K +P           ++++ K    + W  P S     I  Y ++ R K  + 
Sbjct: 30812 VSSVVIIK-SPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNK 30870

Query: 269   WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSE 315
             W  +  E+   T   F+V++L    EY FR++C    G+  WS+ SE
Sbjct: 30871 WISVTTEEIRET--VFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 30915



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 43/161 (26%), Positives = 69/161 (42%), Gaps = 23/161 (14%)

Query: 149   GRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVT 208
             G+E       T+K++  +       A  + P S   D + +Y + +E      N LG  T
Sbjct: 14424 GKEVKASDRLTMKNDHIS-------AHLEVPKSVRAD-AGIYTITLE------NKLGSAT 14469

Query: 209   SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDAS 267
             +  IN   +    P P  ++    S+   S  KLTW  P       IL Y ++ R     
Sbjct: 14470 AS-INVKVIGL--PGPCKDIKA--SDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR 14524

Query: 268   TWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
             T+    P  +   + S+TV+DL P  EY FR++ + + G G
Sbjct: 14525 TYI---PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGG 14562



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
             P PP +L V  S+      +L+W  P       +K Y I+ RT D   W+++ P+  ++T
Sbjct: 15912 PGPPKDLKV--SDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTT 15969

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                F V DL    +Y FR+R     G G
Sbjct: 15970 ---FVVPDLLSEQQYFFRVRAENRFGIG 15994



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 37/128 (28%), Positives = 58/128 (45%), Gaps = 15/128 (11%)

Query: 195   EVWVEAENALG----KVTSDHINF-DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
             E  V AENA G      TS  I   DPV+   P+PP    +++S + +  + + W  P  
Sbjct: 26054 EYRVYAENAAGLSLPSETSPLIRAEDPVFL--PSPPSKPKIVDSGKTT--ITIAWVKPLF 26109

Query: 250   KS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSS-FTVQDLKPFTEYVFRIRCMKEDGK 307
                  I  Y ++Y+  D + W         S R + +T+  L    EYVFR++ + + G 
Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKT----SIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 26165

Query: 308   GYWSDWSE 315
                SD S+
Sbjct: 26166 SDPSDSSD 26173



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 45/176 (25%), Positives = 68/176 (38%), Gaps = 26/176 (14%)

Query: 150   RETHLETNFTLKSEWATH-----KFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEA---- 200
             RE H++   TL+           K    K  RD PT   +D + V    +E+   A    
Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS-KLEIRNAAHEDG 17284

Query: 201   -------ENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNP-SIKSV 252
                    EN  G  T   ++   +   KP PP +L V  SE       LTW  P      
Sbjct: 17285 GIYSLTVENPAGSKT---VSVKVLVLDKPGPPRDLEV--SEIRKDSCYLTWKEPLDDGGS 17339

Query: 253   IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
             +I  Y ++ R   ++ WS   P    S + S   + L    +Y+FR+    + G+G
Sbjct: 17340 VITNYVVERRDVASAQWS---PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRG 17392



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 5/103 (4%)

Query: 215   DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIP 273
             DP++   P PP    V   ++  S + L W  P+      +K Y ++ + +  + W ++ 
Sbjct: 15700 DPIFP--PGPPSCPEV--KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVN 15755

Query: 274   PEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEE 316
               D   T     V +LK   +Y FR++ + E G+   SD + E
Sbjct: 15756 EPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGE 15798



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 13/111 (11%)

Query: 201   ENALGKVTSDHINFDPVYKV--KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKY 257
             EN+ GK       +  V KV   P PP N++V    + S+ +  TW  P I     I+ Y
Sbjct: 19769 ENSCGKK-----EYTIVVKVLDTPGPPVNVTVKEISKDSAYV--TWEPPIIDGGSPIINY 19821

Query: 258   NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              +Q R  +  +WS +  E    +++SF V +L+    Y FR+    E G G
Sbjct: 19822 VVQKRDAERKSWSTVTTE---CSKTSFRVANLEEGKSYFFRVFAENEYGIG 19869



 Score = 37.0 bits (84), Expect = 0.024
 Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 7/87 (8%)

Query: 221   KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
             +P PP  L V+++ + S++L   W  P       I  Y ++ R K +  W     E   +
Sbjct: 28545 QPAPPRRLDVVDTSKSSAVL--AWLKPDHDGGSRITGYLLEMRQKGSDFWV----EAGHT 28598

Query: 280   TRSSFTVQDLKPFTEYVFRIRCMKEDG 306
              + +FTV+ L   TEY FR++   + G
Sbjct: 28599 KQLTFTVERLVEKTEYEFRVKAKNDAG 28625



 Score = 36.6 bits (83), Expect = 0.032
 Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 10/112 (8%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSS-ILKLTWTNPSIKSVI-IL 255
             V A N+ G  T    N   +   KP PP  +  +  +E+S+  + ++W  P+      I 
Sbjct: 24384 VTATNSAGTATE---NLSVIVLEKPGPP--VGPVRFDEVSADFVVISWEPPAYTGGCQIS 24438

Query: 256   KYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
              Y ++ R    +TW  +        R++  +  LK  TEY FRI      GK
Sbjct: 24439 NYIVEKRDTTTTTWHMV---SATVARTTIKITKLKTGTEYQFRIFAENRYGK 24487



 Score = 35.8 bits (81), Expect = 0.054
 Identities = 35/121 (28%), Positives = 49/121 (40%), Gaps = 20/121 (16%)

Query: 198   VEAENALGKVTSDHINFDPVYKVK-----PNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
             V A N +G  T + +  D   + +     P PP N+++ +       + LTW  P     
Sbjct: 13164 VSARNRVG--TGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFG--VSLTWEPPEYDGG 13219

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRS----SFTVQDLKPFTEYVFRIRCMKEDGK 307
               I  Y I+ R K +  W      DTA T      S TV D+    EY FR+R     G 
Sbjct: 13220 AEITNYVIELRDKTSIRW------DTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGV 13273

Query: 308   G 308
             G
Sbjct: 13274 G 13274



 Score = 35.8 bits (81), Expect = 0.054
 Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 4/88 (4%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTAST 280
             P PP  + + +S + S  + L W+ P       +  Y ++ R  +   W+ +  +    T
Sbjct: 27167 PGPPAKIRIADSTKSS--ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRT 27224

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              + + V +LKP   Y FR+  +   G+G
Sbjct: 27225 -TEYVVSNLKPGVNYYFRVSAVNCAGQG 27251



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 42/155 (27%), Positives = 65/155 (41%), Gaps = 16/155 (10%)

Query: 161   KSEWATH----KFADCKAKRDTPTSC--TVDYSTVYFVNIEVWVEAENALGKVTSDHINF 214
             KS W+      + +D      TPTS   T+ Y+T      E  + A N  G    +H+  
Sbjct: 20410 KSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAG-EYTITATNPFGTKV-EHVKV 20467

Query: 215   DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIP 273
               +    P  P  +S +++E+ +    LTWT P       +K Y ++ R      W+ + 
Sbjct: 20468 TVLDVPGPPGPVEISNVSAEKAT----LTWTPPLEDGGSPIKSYILEKRETSRLLWTVVS 20523

Query: 274   PEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              ED  S R   T   L    EY+FR+  +   GKG
Sbjct: 20524 -EDIQSCRHVAT--KLIQGNEYIFRVSAVNHYGKG 20555



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 33/115 (28%), Positives = 48/115 (41%), Gaps = 8/115 (6%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254
             E  +E +N  G  TS+ I    +   KP PP     I+  + +SI  ++W  P +     
Sbjct: 29808 EYTLELKNVTG-TTSETIKV--IILDKPGPPTGPIKIDEIDATSIT-ISWEPPELDGGAP 29863

Query: 255   LK-YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
             L  Y ++ R      W    P   + TRS+F    L    EYVFR+      G G
Sbjct: 29864 LSGYVVEQRDAHRPGWL---PVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIG 29915



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 26/76 (34%), Positives = 32/76 (42%), Gaps = 4/76 (5%)

Query: 241   KLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRI 299
             KLTW +P       I  Y I+ R  D   W+   P     TR + TVQ L     Y FRI
Sbjct: 16634 KLTWFSPEDDGGSPITNYVIEKRESDRRAWT---PVTYTVTRQNATVQGLIQGKAYFFRI 16690

Query: 300   RCMKEDGKGYWSDWSE 315
                   G G + + SE
Sbjct: 16691 AAENSIGMGPFVETSE 16706



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 41/191 (21%), Positives = 72/191 (37%), Gaps = 22/191 (11%)

Query: 126   PEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
             P  P NL+    +   +   W     DGG +    TN+ ++    T K         T T
Sbjct: 25199 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKI---TNYIVEKRETTRKAYATITNNCTKT 25255

Query: 181   SCTVDY---STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELS 237
             +  ++       Y+  +    E    L   T++ +         P PP  +++++    +
Sbjct: 25256 TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE----PPLPPGRVTLVDVTRNT 25311

Query: 238   SILKLTWTNP-SIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
             + +K  W  P S     I  Y ++ +TK +  WS      T       T+  L    EYV
Sbjct: 25312 ATIK--WEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA----TISGLTAGEEYV 25365

Query: 297   FRIRCMKEDGK 307
             FR+  + E G+
Sbjct: 25366 FRVAAVNEKGR 25376



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 37/127 (29%), Positives = 51/127 (40%), Gaps = 17/127 (13%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKP--------NPPHNLSVINSEELSSILKLTWTNPSI 249
             V AEN  G ++    + +PV    P        NPP  L V  S      + L+W+ P  
Sbjct: 30302 VSAENQFG-ISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSS-----VSLSWSRPKD 30355

Query: 250   KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                  +  Y I+   K+ ST   +    T  T + +TV  L P  EY FRI    + G  
Sbjct: 30356 DGGSRVTGYYIE--RKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLS 30413

Query: 309   YWSDWSE 315
               S  SE
Sbjct: 30414 ETSPASE 30420



 Score = 32.7 bits (73), Expect = 0.46
 Identities = 30/108 (27%), Positives = 46/108 (42%), Gaps = 9/108 (8%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIK-SVIILKYNIQYRTKDASTWSQIPPEDTAST 280
             P+PP  L VIN  + ++ LK  WT P       I  Y ++ R      W  +   DT   
Sbjct: 14084 PSPPRWLEVINITKNTADLK--WTVPEKDGGSPITNYIVEKRDVRRKGWQTV---DTTVK 14138

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDNIAS 328
              +  TV  L   + YVFR+      G+   SD++E    +  +D   +
Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQ---SDYTEIEDSVLAKDTFTT 14183



 Score = 32.7 bits (73), Expect = 0.46
 Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 11/120 (9%)

Query: 195   EVWVEAENALG-----KVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
             E  V AEN  G     + +   +  D  Y   P PP N  V ++ + S+   L W  P  
Sbjct: 20643 EFRVSAENRAGIGPPSEASDSVLMKDAAYP--PGPPSNPHVTDTTKKSA--SLAWGKPHY 20698

Query: 250   KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                + I  Y ++++      W +     TA   + F V DL+   +Y FRI  + + G G
Sbjct: 20699 DGGLEITGYVVEHQKVGDEAWIK-DTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757



 Score = 32.3 bits (72), Expect = 0.60
 Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 8/113 (7%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILK 256
             +   N +G+ T+   + + V   KP+PP      +     SI  L+W  P       I  
Sbjct: 23302 ITVANVVGQKTA---SIEIVTLDKPDPPKGPVKFDDVSAESIT-LSWNPPLYTGGCQITN 23357

Query: 257   YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
             Y +Q R    + W  +        R++  V  LK  TEY FRI      G+ +
Sbjct: 23358 YIVQKRDTTTTVWDVV---SATVARTTLKVTKLKTGTEYQFRIFAENRYGQSF 23407



 Score = 32.3 bits (72), Expect = 0.60
 Identities = 40/169 (23%), Positives = 67/169 (39%), Gaps = 25/169 (14%)

Query: 147   DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYST---VYFVNIEVWVEAENA 203
             DGG +     N+ +    +T K     + + + TS  V+  T   +Y+      V AEN 
Sbjct: 24142 DGGAKVK---NYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFR----VMAENE 24194

Query: 204   LGKVTSDHINFDPVYKVK----PNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYN 258
              G      +  + V  VK    P+PP  +++ +  + S+   L W  P       +L Y 
Sbjct: 24195 FGV----GVPVETVDAVKAAEPPSPPGKVTLTDVSQTSA--SLMWEKPEHDGGSRVLGYV 24248

Query: 259   IQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
             ++ + K    WS +      +      V  L    EY FR++   E GK
Sbjct: 24249 VEMQPKGTEKWSIVAESKVCNA----VVTGLSSGQEYQFRVKAYNEKGK 24293



 Score = 32.0 bits (71), Expect = 0.78
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
             P PP NL+V    + S+ L   W  P I     +K Y I  R      ++ +    +  +
Sbjct: 24116 PGPPQNLAVKEVRKDSAFL--VWEPPIIDGGAKVKNYVIDKRESTRKAYANV---SSKCS 24170

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
             ++SF V++L     Y FR+    E G G
Sbjct: 24171 KTSFKVENLTEGAIYYFRVMAENEFGVG 24198



 Score = 31.6 bits (70), Expect = 1.0
 Identities = 45/184 (24%), Positives = 74/184 (40%), Gaps = 23/184 (12%)

Query: 144   CEW-----DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW- 197
             C+W     DGG E     N+TL+ +  T   ++      T   C   YS    +  + + 
Sbjct: 14820 CKWEPPLDDGGSEI---INYTLEKKDKTKPDSEWIVVTSTLRHCK--YSVTKLIEGKEYL 14874

Query: 198   --VEAENALGK----VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS 251
               V AEN  G     V+   +  DP     P+ P    V +    S ++K  W  P    
Sbjct: 14875 FRVRAENRFGPGPPCVSKPLVAKDPFGP--PDAPDKPIVEDVTSNSMLVK--WNEPKDNG 14930

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
               IL Y ++ R  +++ WS++      + +++  V  L     YVFR+      G G +S
Sbjct: 14931 SPILGYWLEKREVNSTHWSRVNKSLLNALKAN--VDGLLEGLTYVFRVCAENAAGPGKFS 14988

Query: 312   DWSE 315
               S+
Sbjct: 14989 PPSD 14992



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 27/90 (30%), Positives = 39/90 (43%), Gaps = 7/90 (7%)

Query: 221   KPNPPHNLSVINSEELSSI-LKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTA 278
             +P PP  +  I  E +S+  + L+W  P       I  Y I+ R  +  TW  +  E   
Sbjct: 16216 RPGPP--VGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKE 16273

Query: 279   STRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              T   +T+  L    EYVFRI    + G G
Sbjct: 16274 CT---YTIPKLLEGHEYVFRIMAQNKYGIG 16300



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 8/118 (6%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYK----VKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
             E  V AEN +G +        PV+      KP+PP N   I++    + + LTW  P   
Sbjct: 17083 EFRVSAENEIG-IGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTT--CNSVDLTWQPPRHD 17139

Query: 251   SVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
                 IL Y ++Y+      W +      +   + + V  L+    Y FR+  +   G+
Sbjct: 17140 GGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE 17197



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 44/180 (24%), Positives = 70/180 (38%), Gaps = 19/180 (10%)

Query: 135   IVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNI 194
             +VN G+  R E D   +  L T   L+ +    + A C+ K     +  +    +     
Sbjct: 23636 VVNAGETFRLEADVHGKP-LPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694

Query: 195   EVWVEAENALGKVTSDHINFDPVYKV--KPNPPHN---LSVINSEELSSILKLTWTNP-S 248
             +  + A N  G  +     F    KV  +P PP     ++ + SE+ S    LTW+ P  
Sbjct: 23695 QYILRASNVAGSKS-----FPVNVKVLDRPGPPEGPVQVTGVTSEKCS----LTWSPPLQ 23745

Query: 249   IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                  I  Y ++ R      W+ +  E   +   S  V  L    EYVFRI  + + G G
Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTN---SLKVTKLLEGNEYVFRIMAVNKYGVG 23802



 Score = 30.4 bits (67), Expect = 2.3
 Identities = 35/121 (28%), Positives = 50/121 (41%), Gaps = 14/121 (11%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKP----NPPHNLSVINSEELSSILKLTWTNPSIKS-V 252
             V+AEN +G +    +   PV    P     PP N  V+++ + S  + L W  P      
Sbjct: 18470 VKAENEIG-IGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHS--ITLGWGKPVYDGGA 18526

Query: 253   IILKYNIQYRTK--DAST---WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
              I+ Y ++ R K  DAS    W +         R  FTV  L    EY FR+    + G 
Sbjct: 18527 PIIGYVVEMRPKIADASPDEGWKRCNAA-AQLVRKEFTVTSLDENQEYEFRVCAQNQVGI 18585

Query: 308   G 308
             G
Sbjct: 18586 G 18586



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 26/116 (22%), Positives = 49/116 (42%), Gaps = 10/116 (8%)

Query: 195   EVWVEAENALG-KVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI 253
             E  +   NA G K  + H+    V    P  P N+  +  E ++    ++W  P      
Sbjct: 17580 EYQITVSNAAGSKTVAVHLTVLDV-PGPPTGPINILDVTPEHMT----ISWQPPKDDGGS 17634

Query: 254   -ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
              ++ Y ++ +     TW  +    + S+++   +  L+   EYVFR+R   + G G
Sbjct: 17635 PVINYIVEKQDTRKDTWGVV---SSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVG 17687



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 6/94 (6%)

Query: 215   DPVYKVKP-NPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQI 272
             +PV  + P +PP    VIN    S  + L WT P       L  Y ++ R   + +W + 
Sbjct: 20266 EPVVALDPIDPPGKPEVINITRNS--VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKA 20323

Query: 273   PPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDG 306
                +      +FTV DL    +Y FRIR     G
Sbjct: 20324 NHVNVPEC--AFTVTDLVEGGKYEFRIRAKNTAG 20355



 Score = 29.3 bits (64), Expect = 5.0
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)

Query: 212   INFDPVYKVKP-NPPHNLSVIN-SEELSSILKLTWTNP-SIKSVIILKYNIQYRTKDAST 268
             +   P+  V P  PP +   +  +E   S + L W  P S     I  Y I+ R  D   
Sbjct: 15281 VEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPD 15340

Query: 269   WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
             + ++      +T  SF V++L     Y FR++ + E G+
Sbjct: 15341 FERVNKRLCPTT--SFLVENLDEHQMYEFRVKAVNEIGE 15377



 Score = 29.3 bits (64), Expect = 5.0
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 13/175 (7%)

Query: 147   DGGRETHLETNFTL-KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALG 205
             DGG E    TN+ + K E +   +A   A     TSC+V+   +     +  + AEN  G
Sbjct: 19415 DGGSEI---TNYIVDKRETSRPNWAQVSATVPI-TSCSVE-KLIEGHEYQFRICAENKYG 19469

Query: 206   KVTSDHINFDPVYKVKP-NPPHNLSV-INSEELSSILKLTWTNPSIKSVI-ILKYNIQYR 262
                 D +  +P     P +PP      + S      + ++W  P+      I  Y ++ R
Sbjct: 19470 --VGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR 19527

Query: 263   TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317
                A  W+++  +         T   L+  TEY FR+  + + G G  SD S+ A
Sbjct: 19528 ETQAVNWTKVNRKPIIERTLKAT--GLQEGTEYEFRVTAINKAGPGKPSDASKAA 19580



 Score = 29.3 bits (64), Expect = 5.0
 Identities = 22/95 (23%), Positives = 40/95 (42%), Gaps = 6/95 (6%)

Query: 221   KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
             +P PP  + +   E     + ++W  P       I  Y ++ +   ++TW  +     A 
Sbjct: 25487 RPGPPGPIRI--DEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV---SQAV 25541

Query: 280   TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
              R+S  +  L   +EY FR+      GK  +S+ S
Sbjct: 25542 ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESS 25576


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,542,502
Number of Sequences: 37866
Number of extensions: 572843
Number of successful extensions: 1859
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 1340
Number of HSP's gapped (non-prelim): 518
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.