Guide to the Human Genome
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Search of human proteins with 28610147

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
         (918 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...  1888   0.0  
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...   674   0.0  
gi|115430248 gp130-like monocyte receptor [Homo sapiens]              255   1e-67
gi|4503081 colony stimulating factor 3 receptor isoform a precur...   249   1e-65
gi|27437045 colony stimulating factor 3 receptor isoform d precu...   245   1e-64
gi|24496783 colony stimulating factor 3 receptor isoform c precu...   241   2e-63
gi|27437042 colony stimulating factor 3 receptor isoform b precu...   215   2e-55
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s...   187   4e-47
gi|189083786 leukemia inhibitory factor receptor precursor [Homo...   187   4e-47
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]   167   3e-41
gi|4557040 oncostatin M receptor [Homo sapiens]                       135   1e-31
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]             122   2e-27
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                  103   7e-22
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                  103   7e-22
gi|40254464 leptin receptor isoform 1 [Homo sapiens]                  103   7e-22
gi|4759328 class I cytokine receptor [Homo sapiens]                    87   9e-17
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...    80   9e-15
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...    80   9e-15
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...    80   9e-15
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...    76   1e-13
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...    76   1e-13
gi|222352127 sidekick 2 [Homo sapiens]                                 75   4e-13
gi|119220552 sidekick 1 [Homo sapiens]                                 74   6e-13
gi|24430212 interleukin 23 receptor precursor [Homo sapiens]           74   8e-13
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...    74   8e-13
gi|4506107 prolactin receptor [Homo sapiens]                           73   1e-12
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...    73   1e-12
gi|22212918 ciliary neurotrophic factor receptor preproprotein [...    67   6e-11
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H...    67   6e-11
gi|110349719 titin isoform N2-A [Homo sapiens]                         62   3e-09

>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score = 1888 bits (4891), Expect = 0.0
 Identities = 918/918 (100%), Positives = 918/918 (100%)

Query: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
           MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60

Query: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
           NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120

Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
           ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180

Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240

Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
           KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300

Query: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360
           CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360

Query: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420
           GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD
Sbjct: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420

Query: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480
           FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT
Sbjct: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480

Query: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540
           YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
Sbjct: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540

Query: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600
           QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG
Sbjct: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600

Query: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660
           KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK
Sbjct: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660

Query: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720
           SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN
Sbjct: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720

Query: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780
           TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS
Sbjct: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780

Query: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840
           ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV
Sbjct: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840

Query: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900
           NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG
Sbjct: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900

Query: 901 MPKSYLPQTVRQGGYMPQ 918
           MPKSYLPQTVRQGGYMPQ
Sbjct: 901 MPKSYLPQTVRQGGYMPQ 918


>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score =  674 bits (1739), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
           MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1   MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60

Query: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
           NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61  NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120

Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
           ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180

Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240

Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
           KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300

Query: 301 CMKEDGKGYWSDWSEEASGITYED 324
           CMKEDGKGYWSDWSEEASGITYED
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYED 324


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score =  255 bits (652), Expect = 1e-67
 Identities = 163/551 (29%), Positives = 268/551 (48%), Gaps = 14/551 (2%)

Query: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKAKRDTP---TS 181
           P KP+N+SC+    K + C W  G+ET   T +T+K  +A   K  +C     T     S
Sbjct: 54  PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112

Query: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239
           C+     +    N  + VEAEN  G + S H+ +  +  + K  PP    V     +  +
Sbjct: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171

Query: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297
           +++ W  P +  V   LKY +++RT ++++W ++   ++      ++ +  L+PFTEYV 
Sbjct: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231

Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPF 357
            +RC  ++ K +WSDWS+E  G+T E+ P      W  + P+   G R V+L+WK     
Sbjct: 232 ALRCAVKESK-FWSDWSQEKMGMTEEEAPCGL-ELWRVLKPAEADGRRPVRLLWKKARGA 289

Query: 358 EANGKILDYEVTLTRWKSHLQNYTVNAT--KLTVNLTNDRYLATLTVRNLVGKSDAAVLT 415
               K L Y +      +     T+N T  +L ++L  + +  ++   N +GKS  A L 
Sbjct: 290 PVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLR 349

Query: 416 IPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475
           IPA   ++   +  ++A   ++ L V+W +    V  +++EW    D  P    W+    
Sbjct: 350 IPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQ 409

Query: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEA 535
             + T  +  L    CY I+V P+  D  G P SI+AY K+  PS+GP  + + +G    
Sbjct: 410 ATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTV 469

Query: 536 VLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAY 595
            + W ++P   + G I NYTIFY+   G   +  V+SS  +Y L SL   T Y+V++ A 
Sbjct: 470 TITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMAS 529

Query: 596 TDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNV 655
           T  GG +G    F T  F+  EI  I   +    L+  +L V +   K + +    WP V
Sbjct: 530 TSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTV 589

Query: 656 PDPSKSHIAQW 666
           P+P++S IA W
Sbjct: 590 PNPAESSIATW 600


>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
           [Homo sapiens]
          Length = 836

 Score =  249 bits (635), Expect = 1e-65
 Identities = 227/813 (27%), Positives = 357/813 (43%), Gaps = 76/813 (9%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
           E +      L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
            P T Y  +IRC++    G+WSDWS      T E  P+     W++   +DP      RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351

Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
           VQL WK +P  E +G+I  Y V+   W+   Q   +    N T+L  T +L ++     L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408

Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
              N  G S       P    ++  P +  L A  +D + LWV W  P    + Y++EW 
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464

Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
           +    A      W+ E +G      L+ N+   + Y I VTP+Y D  G  + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
             PS  P +  K +GK  A LEW   P ++    + +YTIF+        +  +++S   
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584

Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
           + L  L   +LY + + A +  G  +    T  T      E+  I+    L  LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644

Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694
              L C   R   K  +WP+VPDP+ S +  W P       F    Q+   G      + 
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697

Query: 695 EIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTS 754
            +E ++KKP P   +S +  +   + T   +  + G     S++P        +S   TS
Sbjct: 698 VLEEDEKKPVP--WESHNSSETCGLPTLVQTYVLQGDPRAVSTQP--------QSQSGTS 747

Query: 755 STVQYSTVVHSGYRHQVPSVQVFSRSESTQPLL 787
             V Y  ++ S      P    + R +STQPLL
Sbjct: 748 DQVLYGQLLGS---PTSPGPGHYLRCDSTQPLL 777


>gi|27437045 colony stimulating factor 3 receptor isoform d
           precursor [Homo sapiens]
          Length = 783

 Score =  245 bits (626), Expect = 1e-64
 Identities = 208/731 (28%), Positives = 325/731 (44%), Gaps = 63/731 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
           E +      L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
            P T Y  +IRC++    G+WSDWS      T E  P+     W++   +DP      RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351

Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
           VQL WK +P  E +G+I  Y V+   W+   Q   +    N T+L  T +L ++     L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408

Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
              N  G S       P    ++  P +  L A  +D + LWV W  P    + Y++EW 
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464

Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
           +    A      W+ E +G      L+ N+   + Y I VTP+Y D  G  + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
             PS  P +  K +GK  A LEW   P ++    + +YTIF+        +  +++S   
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584

Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
           + L  L   +LY + + A +  G  +    T  T      E+  I+    L  LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644

Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694
              L C   R   K  +WP+VPDP+ S +  W P       F    Q+   G      + 
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697

Query: 695 EIEANDKKPFP 705
            +E ++KKP P
Sbjct: 698 VLEEDEKKPVP 708


>gi|24496783 colony stimulating factor 3 receptor isoform c
           precursor [Homo sapiens]
          Length = 863

 Score =  241 bits (615), Expect = 2e-63
 Identities = 200/694 (28%), Positives = 312/694 (44%), Gaps = 59/694 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
           E +      L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
            P T Y  +IRC++    G+WSDWS      T E  P+     W++   +DP      RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351

Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
           VQL WK +P  E +G+I  Y V+   W+   Q   +    N T+L  T +L ++     L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408

Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
              N  G S       P    ++  P +  L A  +D + LWV W  P    + Y++EW 
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464

Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
           +    A      W+ E +G      L+ N+   + Y I VTP+Y D  G  + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
             PS  P +  K +GK  A LEW   P ++    + +YTIF+        +  +++S   
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584

Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
           + L  L   +LY + + A +  G  +    T  T      E+  I+    L  LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644

Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSP 668
              L C   R   K  +WP+VPDP+ S +  W P
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVP 675


>gi|27437042 colony stimulating factor 3 receptor isoform b
           precursor [Homo sapiens]
          Length = 769

 Score =  215 bits (547), Expect = 2e-55
 Identities = 179/634 (28%), Positives = 285/634 (44%), Gaps = 54/634 (8%)

Query: 6   TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
           TW   AL I L   S    L+ CG+IS  +P+V L    TA C++K+ C    H++    
Sbjct: 10  TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60

Query: 65  IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
           I+W+      P  ++Q        S +T   +      L+C  L +G   Q +  + + +
Sbjct: 61  ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119

Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
           G PP  P NLSC++N     + C+W+ G ETHL T+FTLKS       +       DC  
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179

Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
           K      C      + + N+ +WV+AENALG   S  +  DP+  VK  PP   ++  S 
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239

Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
           E +      L+L W        I  K  ++++  +  ++W+ + P    + +  + +  L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297

Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
            P T Y  +IRC++    G+WSDWS      T E  P+     W++   +DP      RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351

Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
           VQL WK +P  E +G+I  Y V+   W+   Q   +    N T+L  T +L ++     L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408

Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
              N  G S       P    ++  P +  L A  +D + LWV W  P    + Y++EW 
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464

Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
           +    A      W+ E +G      L+ N+   + Y I VTP+Y D  G  + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
             PS  P +  K +GK  A LEW   P ++    + +YTIF+        +  +++S   
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584

Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTT 610
           + L  L   +LY + + A +  G  +    T  T
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMT 618


>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score =  187 bits (475), Expect = 4e-47
 Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313

Query: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355

Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413

Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470

Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528

Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377
           +T E  PSK P  W +     +   + + + WK LP  EANGKIL Y V+ +       L
Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584

Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434
                   K  + L  + Y+ ++  +N VG    S  A + IP  D +    V   K   
Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642

Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493
               + + W         Y+++WC  S   PC+ DW++       T +  +       Y 
Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698

Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553
             +      G     S+  Y+++  P   P    +    +  +++W+ +PV+   GF+R 
Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758

Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
           Y  ++          R +    + + V    D S     ++ L   T Y + + AYTD G
Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818

Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659
                     T + + G I AI++PV +A ++  +  +L C+ KR+ IK+  +P++P+P 
Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877

Query: 660 KSHIAQW 666
                Q+
Sbjct: 878 NCKALQF 884


>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score =  187 bits (475), Expect = 4e-47
 Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313

Query: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355

Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413

Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470

Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528

Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377
           +T E  PSK P  W +     +   + + + WK LP  EANGKIL Y V+ +       L
Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584

Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434
                   K  + L  + Y+ ++  +N VG    S  A + IP  D +    V   K   
Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642

Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493
               + + W         Y+++WC  S   PC+ DW++       T +  +       Y 
Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698

Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553
             +      G     S+  Y+++  P   P    +    +  +++W+ +PV+   GF+R 
Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758

Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
           Y  ++          R +    + + V    D S     ++ L   T Y + + AYTD G
Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818

Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659
                     T + + G I AI++PV +A ++  +  +L C+ KR+ IK+  +P++P+P 
Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877

Query: 660 KSHIAQW 666
                Q+
Sbjct: 878 NCKALQF 884


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score =  167 bits (424), Expect = 3e-41
 Identities = 168/640 (26%), Positives = 264/640 (41%), Gaps = 63/640 (9%)

Query: 72  FTIPKEQYTIINRTASSVTFTDIASLNIQLT----------CNILTFGQLEQNVYGITII 121
           F   +    I+ +    + F    SLN Q+T          C +      E  + G  I 
Sbjct: 60  FHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIF 119

Query: 122 SGLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKR---- 176
            G+ PE+P+NLSCI   E   + C W+ GR+THL T +TL+     +     + K     
Sbjct: 120 VGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCD 179

Query: 177 --DTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
             D   + T +       N    V A N+LG  +S    F  +  V+P PP ++ +   +
Sbjct: 180 YLDFGINLTPESPES---NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQK 236

Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
              S   L W +  +    +L   ++YR  ++  W+ +   +    +    + DLKPFTE
Sbjct: 237 ASVSRCTLYWRDEGL----VLLNRLRYRPSNSRLWNMV---NVTKAKGRHDLLDLKPFTE 289

Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY---KIDPSHTQGYRTVQLVW 351
           Y F+I       KG WSDWSE     T E+ P+     WY    ID S  Q    + L W
Sbjct: 290 YEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQ----ISLFW 345

Query: 352 KTLPPFEANGKILDYEVT---LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGK 408
           K L   EA GKIL Y+VT   LT  K+  QN T + +  TV      +   ++  N  G 
Sbjct: 346 KNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGS 405

Query: 409 S-DAAVLTIPACDFQATHP-VMDLKAFPKDNMLWVEWTTPRE---SVKKYILEWCVL--S 461
           S    +  +  C+     P  +   +   DN+L V W  PR+   +V++Y++EW  L   
Sbjct: 406 SLPTRINIMNLCEAGLLAPRQVSANSEGMDNIL-VTWQPPRKDPSAVQEYVVEWRELHPG 464

Query: 462 DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSK 521
                  +W +         +  N+    CY I V  +  D  G   SI    K   P  
Sbjct: 465 GDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGD-QGGCSSILGNSKHKAPLS 523

Query: 522 GPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE----TAVNVDSSHTEY 577
           GP +      K   ++ W+ +PV  Q G + +Y I+++    N       +    S   +
Sbjct: 524 GPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSH 583

Query: 578 TLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTTPKFAQGEIE--AIVVP-VCLAFLLTT 633
            ++SL     Y++ M A T  G    G E  F      QG+    A V P +C+A ++  
Sbjct: 584 PINSLQPRVTYVLWMTALTAAGESSHGNEREFC----LQGKANWMAFVAPSICIAIIMVG 639

Query: 634 LLGVLFCFNKRDLIKKHIWP-----NVPDPSKSHIAQWSP 668
           +    +   K  ++   + P      +PDP+ S  A+  P
Sbjct: 640 IFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYP 679


>gi|4557040 oncostatin M receptor [Homo sapiens]
          Length = 979

 Score =  135 bits (341), Expect = 1e-31
 Identities = 140/587 (23%), Positives = 232/587 (39%), Gaps = 56/587 (9%)

Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHL------ETNFTLKS 162
           G + + + GI +      E+PK+ SC   + K + C WD G +T L        ++TL  
Sbjct: 220 GNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFE 279

Query: 163 EWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
            ++  K   C  K       T D    Y       + AEN L K  S +I F+  ++V  
Sbjct: 280 SFSGEKKL-CTHKNWCNWQITQDSQETY----NFTLIAENYLRK-RSVNILFNLTHRVYL 333

Query: 223 NPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
             P +++  N    ++I  +TW   SI++       I+   +       +    +     
Sbjct: 334 MNPFSVNFENVNATNAI--MTWKVHSIRNNFTYLCQIELHGEGKMMQYNV----SIKVNG 387

Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ 342
            + + +L+P TEY+ R+RC        WS+WS + +  T E  PS+AP  W  +  S   
Sbjct: 388 EYFLSELEPATEYMARVRCADASHFWKWSEWSGQ-NFTTLEAAPSEAPDVWRIV--SLEP 444

Query: 343 GYRTVQLVWKTLPPFEANGKILDYEVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLA 398
           G  TV L WK L    ANGKIL Y V +        S L +    A    + L    Y  
Sbjct: 445 GNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQI 504

Query: 399 TLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWC 458
            +   N VG S A+V+ I A        V + +    +    + W      V  Y+++WC
Sbjct: 505 CVIANNSVGASPASVIVISA--DPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWC 562

Query: 459 VLSDKAPCITDWQQEDGTVHRTYLR------GNLAESKCYLITVTPVYADGPGSPESIKA 512
             +        W+        T +       G   + + Y ++   +        E    
Sbjct: 563 DHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIAC----LLEKKTG 618

Query: 513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGN-----ETA 567
           Y ++  PS  P V    +  +   L W     + Q GFI+ Y ++ ++         E A
Sbjct: 619 YSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKA 678

Query: 568 VNVDSS-----------HTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQG 616
           V  D S                + +L  ++ Y   +  +T  G  +GP  TFT       
Sbjct: 679 VLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAG--EGPSATFTKVT-TPD 735

Query: 617 EIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHI 663
           E  ++++ + L  +   LL ++ C+ K   IK+  +P++PDP KS I
Sbjct: 736 EHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSI 782


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score =  122 bits (306), Expect = 2e-27
 Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%)

Query: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90
           ISP+ P + + S+  A C +     D     A  + W  N   +P E   ++N +  ++ 
Sbjct: 43  ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99

Query: 91  FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
             ++     +   N++   +    + G  +  GLPPEKP N+SC     K + C W  G 
Sbjct: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159

Query: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206
             ET L TN++LK +   +   +   +  T  P SC +      F   E+WVEA N LG 
Sbjct: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219

Query: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264
             SD +  D +  V  +PP ++ V     L   L + W + P++K  +   KY I+YR +
Sbjct: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279

Query: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319
           D+  W  +   D  S ++S  +  LKP T Y  ++RC           G WS+WS   + 
Sbjct: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336

Query: 320 IT 321
            T
Sbjct: 337 ST 338


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score =  103 bits (257), Expect = 7e-22
 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
           YWS+WS  A  +  + + P + P FW  I+    +  + V L+WK L   ++   +  Y 
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680

Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
           +   T           N TK T   T   +  T+   N +G S A      +      + 
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740

Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
           V  L A+P   + + V W       K   +I+EW  L++       W +   +V + Y+ 
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798

Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
            +    + Y  ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score =  103 bits (257), Expect = 7e-22
 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
           YWS+WS  A  +  + + P + P FW  I+    +  + V L+WK L   ++   +  Y 
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680

Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
           +   T           N TK T   T   +  T+   N +G S A      +      + 
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740

Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
           V  L A+P   + + V W       K   +I+EW  L++       W +   +V + Y+ 
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798

Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
            +    + Y  ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score =  103 bits (257), Expect = 7e-22
 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)

Query: 33  PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
           P   +  + SN +  C+ K++      V +  IVW  N    IP+ QY +++   S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393

Query: 92  TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
            ++         + +    CN          +Y I +   +  E    L+       KM 
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446

Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
           C W         E+ L+  +   S + +     H  +   DC  + D    C   +  ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504

Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            ++   +W+   ++LG + S      P   VKP PP ++    +  +  +LK++W  P  
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563

Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                L++ I+Y        W      D  S   S  V DL     Y  ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620

Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
           YWS+WS  A  +  + + P + P FW  I+    +  + V L+WK L   ++   +  Y 
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680

Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
           +   T           N TK T   T   +  T+   N +G S A      +      + 
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740

Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
           V  L A+P   + + V W       K   +I+EW  L++       W +   +V + Y+ 
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798

Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
            +    + Y  ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)

Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
           K+TS  + F        P+  VKP+PP  L +  +++ +  LK++W++P +     + + 
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266

Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
           +QY+ K +   + +  E D   + +S  V  + P + Y  ++R  + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323


>gi|4759328 class I cytokine receptor [Homo sapiens]
          Length = 636

 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 105/498 (21%), Positives = 180/498 (36%), Gaps = 34/498 (6%)

Query: 219 KVKPNPPH-NLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277
           ++KPN P     V  SE+      + W  P+  S  +L     YR    + W+ + PE  
Sbjct: 125 QMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELK 184

Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
               +   +QDL+  T Y    RC  E  +  W +WS     ++++  PS     W   +
Sbjct: 185 TIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPI---LSFQTPPSAPKDVWVSGN 241

Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397
              T G     L+WK      A G  +     +  W    +      T     + +    
Sbjct: 242 LCGTPGGEEPLLLWK------APGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEW 295

Query: 398 ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEW 457
           A ++  N         L++   D  +    + + +      L V W        +++++W
Sbjct: 296 ARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDW 355

Query: 458 CVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQA 517
               D    + +W +         L GN      Y ITVT V A G  S  S+  + ++ 
Sbjct: 356 ARDGDPLEKL-NWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREEL 414

Query: 518 PPSKGPTV-RTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
            P  GPT+ R +        + W ++P     G + +YT+  ++       +NV  +   
Sbjct: 415 APLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQS 474

Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
            TL  L      +   A+     G  GP      P      +   V+P  L      LLG
Sbjct: 475 VTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLP---DNTLRWKVLPGILFLWGLFLLG 531

Query: 637 VLF-------CFNKR-DLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNF 688
                     C++ R  ++ + +W  VPDP+ S   Q  PH          +Q+      
Sbjct: 532 CGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQ--PH---------MEQVPEAQPL 580

Query: 689 TDVSVVEIEANDKKPFPE 706
            D+ ++E+E  +  P  E
Sbjct: 581 GDLPILEVEEMEPPPVME 598


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
           precursor [Homo sapiens]
          Length = 1912

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)

Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
           K  P PP    V  +E  ++ + LTW + + + V    Y IQ++ K++   + +I  +  
Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373

Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
           A+TR  ++V  L P+++Y FR+  +   G+G     SE     T E  PS AP       
Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
            S T    T+ + WK   P E NG+I  Y V  T   + H+ N+    V  +++T   NL
Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482

Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
              +      LA  ++ +    SD  V+T      Q     ++ KA P+ +  + + WT 
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538

Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
           PR +++  Y L   V  D    +   IT    E GT +R  L+G L  +  Y   +    
Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589

Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
             G G S   I A   Q+ PS  P  +          ++ W   PV+ QNG I  Y+I Y
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
             + G +      + + S  T+Y L  L   T Y + + A+TD G   GPE
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%)

Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281
           P  P N       E S +L  +WT P  +S  I  Y + Y+  +     +I    T    
Sbjct: 516 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 567

Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341
           +S+ +Q LKP + Y FR+      G G  +    E S  T + +PS  P       PS T
Sbjct: 568 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 624

Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394
               ++ + W+  P  + NG I +Y +  T       K H +     + TK  +      
Sbjct: 625 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 680

Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446
             Y  T+T    VG      +VL     D  +  P            + V W +P     
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740

Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
              ++ Y + +            +L D       W+ +D T H   + G   E+  Y +T
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 799

Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
           VT     G G+    K           P +       N A+++W   PVD   G ++ Y 
Sbjct: 800 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 857

Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
           + F R  +   T +        +T + +     Y+ R++A    G
Sbjct: 858 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 902



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%)

Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
           S+ + + W  P   +  I  Y + Y    T+  + W +    D+  T    T+ +L P  
Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486

Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
            Y  ++      G G     S +   IT    P +  +F  K +P   +   ++ L W  
Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537

Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
            PP   +  I +YE+     +    Q  T+    + +L     N  Y   L  R+  G  
Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594

Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
           +  A ++      + + P  D+    P    + V W  P  E     I E+ +       
Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648

Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
            T    ED   H           YL   L +   Y ITVT     GPG PES+   ++  
Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707

Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570
                 PP K   V  + V      + W     + Q+G IR Y + Y  +   E      
Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764

Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
                         D++  +  +S L  +T Y + + AYT   +G +  P+   TT
Sbjct: 765 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%)

Query: 507  PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566
            PE +     Q   S+G T            L W    +  +NG I  YT+ YR I  N  
Sbjct: 914  PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 964

Query: 567  AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
             + ++     + T  TL+ L  DT Y V++ A+T +G G   P   F T
Sbjct: 965  LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%)

Query: 237  SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291
            S+ ++L+W  P +  ++ II KY + YR  +         I P DT     + T+  LKP
Sbjct: 932  STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 986

Query: 292  FTEYVFRIRCMKEDGKGYWS 311
             T Y  ++R     G G +S
Sbjct: 987  DTTYDVKVRAHTSKGPGPYS 1006


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
           2 precursor [Homo sapiens]
          Length = 1899

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)

Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
           K  P PP    V  +E  ++ + LTW + + + V    Y IQ++ K++   + +I  +  
Sbjct: 307 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 360

Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
           A+TR  ++V  L P+++Y FR+  +   G+G     SE     T E  PS AP       
Sbjct: 361 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 415

Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
            S T    T+ + WK   P E NG+I  Y V  T   + H+ N+    V  +++T   NL
Sbjct: 416 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 469

Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
              +      LA  ++ +    SD  V+T      Q     ++ KA P+ +  + + WT 
Sbjct: 470 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 525

Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
           PR +++  Y L   V  D    +   IT    E GT +R  L+G L  +  Y   +    
Sbjct: 526 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 576

Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
             G G S   I A   Q+ PS  P  +          ++ W   PV+ QNG I  Y+I Y
Sbjct: 577 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636

Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
             + G +      + + S  T+Y L  L   T Y + + A+TD G   GPE
Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 685



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%)

Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281
           P  P N       E S +L  +WT P  +S  I  Y + Y+  +     +I    T    
Sbjct: 503 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 554

Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341
           +S+ +Q LKP + Y FR+      G G  +    E S  T + +PS  P       PS T
Sbjct: 555 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 611

Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394
               ++ + W+  P  + NG I +Y +  T       K H +     + TK  +      
Sbjct: 612 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667

Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446
             Y  T+T    VG      +VL     D  +  P            + V W +P     
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727

Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
              ++ Y + +            +L D       W+ +D T H   + G   E+  Y +T
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 786

Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
           VT     G G+    K           P +       N A+++W   PVD   G ++ Y 
Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 844

Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
           + F R  +   T +        +T + +     Y+ R++A    G
Sbjct: 845 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 889



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%)

Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
           S+ + + W  P   +  I  Y + Y    T+  + W +    D+  T    T+ +L P  
Sbjct: 418 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 473

Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
            Y  ++      G G     S +   IT    P +  +F  K +P   +   ++ L W  
Sbjct: 474 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 524

Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
            PP   +  I +YE+     +    Q  T+    + +L     N  Y   L  R+  G  
Sbjct: 525 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 581

Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
           +  A ++      + + P  D+    P    + V W  P  E     I E+ +       
Sbjct: 582 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 635

Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
            T    ED   H           YL   L +   Y ITVT     GPG PES+   ++  
Sbjct: 636 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 694

Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570
                 PP K   V  + V      + W     + Q+G IR Y + Y  +   E      
Sbjct: 695 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 751

Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
                         D++  +  +S L  +T Y + + AYT   +G +  P+   TT
Sbjct: 752 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%)

Query: 507  PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566
            PE +     Q   S+G T            L W    +  +NG I  YT+ YR I  N  
Sbjct: 901  PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 951

Query: 567  AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
             + ++     + T  TL+ L  DT Y V++ A+T +G G   P   F T
Sbjct: 952  LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%)

Query: 237 SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291
           S+ ++L+W  P +  ++ II KY + YR  +         I P DT     + T+  LKP
Sbjct: 919 STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 973

Query: 292 FTEYVFRIRCMKEDGKGYWS 311
            T Y  ++R     G G +S
Sbjct: 974 DTTYDVKVRAHTSKGPGPYS 993


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
           3 precursor [Homo sapiens]
          Length = 1903

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)

Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
           K  P PP    V  +E  ++ + LTW + + + V    Y IQ++ K++   + +I  +  
Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373

Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
           A+TR  ++V  L P+++Y FR+  +   G+G     SE     T E  PS AP       
Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
            S T    T+ + WK   P E NG+I  Y V  T   + H+ N+    V  +++T   NL
Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482

Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
              +      LA  ++ +    SD  V+T      Q     ++ KA P+ +  + + WT 
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538

Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
           PR +++  Y L   V  D    +   IT    E GT +R  L+G L  +  Y   +    
Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589

Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
             G G S   I A   Q+ PS  P  +          ++ W   PV+ QNG I  Y+I Y
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
             + G +      + + S  T+Y L  L   T Y + + A+TD G   GPE
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 89/415 (21%), Positives = 166/415 (40%), Gaps = 43/415 (10%)

Query: 221  KPN-PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDT 277
            KP+ PP ++S   S   +SIL ++W  P ++    II +Y+I+Y   D            
Sbjct: 608  KPSAPPQDISC-TSPSSTSIL-VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665

Query: 278  ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI--TYEDRPSKAPSFWYK 335
             S  + + ++ L+ +TEY   +    + G G      E  S +  T ED PS  P    K
Sbjct: 666  PSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-----PESLSVLIRTNEDVPSGPPR---K 717

Query: 336  IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN--------YTVNATKL 387
            ++        +V++ W++  P + +G+I  Y+V   R ++               +A  +
Sbjct: 718  VEVEAVNS-TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDM 776

Query: 388  TVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAF--PKDNMLWVEWTT 445
             ++        +LTV     K D A             P          + N   ++W  
Sbjct: 777  IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP 836

Query: 446  PRES---VKKYILEWCVLSDKAPCIT-DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYA 501
            P ++   ++ Y L++    D  P  T ++ +++     T    ++ +   Y+  ++    
Sbjct: 837  PVDTFGPLQGYRLKFG-RKDMEPLTTLEFSEKEDHFTAT----DIHKGASYVFRLSARNK 891

Query: 502  DGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560
             G G     +  + +  P+  P  + ++        L W    +  +NG I  YT+ YR 
Sbjct: 892  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951

Query: 561  IIGNETAVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
            I  N   + ++     + T  TL+ L  DT Y V++ A+T +G G   P   F T
Sbjct: 952  I--NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 90/407 (22%), Positives = 147/407 (36%), Gaps = 59/407 (14%)

Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
           S+ + + W  P   +  I  Y + Y    T+  + W +    D+  T    T+ +L P  
Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486

Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
            Y  ++      G G     S +   IT    P +  +F  K +P   +   ++ L W  
Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537

Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
            PP   +  I +YE+     +    Q  T+    + +L     N  Y   L  R+  G  
Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594

Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
           +  A ++      + + P  D+    P    + V W  P  E     I E+ +       
Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648

Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
            T    ED   H           YL   L +   Y ITVT     GPG PES+   ++  
Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707

Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-- 569
                 PP K   V  + V      + W     + Q+G IR Y + Y  +   E      
Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764

Query: 570 ----VDSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
               + +   +  +S L  +T Y + + AYT   +G +  P+   TT
Sbjct: 765 LKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 811


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
           1 precursor [Homo sapiens]
          Length = 1907

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%)

Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278
           K  P PP +L V  +E  ++ + LTW + + + V    Y IQYR   A T       D  
Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369

Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338
           +T + +++  L PF+EY FR+  +   G+G     SE     T E  PS  P    +   
Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421

Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388
           +      T+ + W+  PP E NG +  Y V  T         W  H  +  +  T   L 
Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442
             +T   R LA   V +        V T   +PA   DFQA     ++++  +  + W+ 
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533

Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500
              P+E +  Y L +    D+       QQ   T   T  Y   +L     Y   +    
Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586

Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
             G G    +I+A   Q+ PS  P  V    +G     + W   P D +NG I  Y++ Y
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646

Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
             + G +   +V       H+ + L  L   T Y V + A+TD G   GPE
Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 87/407 (21%), Positives = 167/407 (41%), Gaps = 51/407 (12%)

Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281
           PP  +  ++    S+ ++++W  P   S   +I +Y++ Y   D     +   +  +   
Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666

Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338
           SS+ +  L+ +TEY   +R   + G G       E+S +   T ED PS  P    +++P
Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719

Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR---------------------WK-SH 376
            ++     V + WK   P + +G+I  Y+VT  R                     W+   
Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE 776

Query: 377 LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKD 436
            ++Y    + LT   T    +A  T +    +S   ++T          P M +     +
Sbjct: 777 SEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMN 834

Query: 437 NMLWVEWTTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYL 493
             L ++W  P+E    +  Y L++C   +  P   D+ ++D    + +    L +   Y+
Sbjct: 835 TAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYI 889

Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552
             +      G G     +    +  PS  P  +    +  +   L WD   +  +NG I 
Sbjct: 890 FRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949

Query: 553 NYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
           +YT+ +R I   +   N+ ++ T +TL+ L  DT Y +++ A+T +G
Sbjct: 950 SYTVVFRDINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 995



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 83/411 (20%), Positives = 149/411 (36%), Gaps = 54/411 (13%)

Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
           E  + ++L+W  P  + +I+ +  + +  +D     ++  + T    SS+T++DLKP T 
Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577

Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354
           Y F++    + G G ++   E     T +  PS  P     +    + G  TV++ W   
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630

Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400
           P    NG I  Y V                   + H     V   K T       Y   +
Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684

Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453
                VG   +++ + +   +   + P   ++  P ++  + V W  P  S     ++ Y
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744

Query: 454 ILEWCVLSDKAP-----------CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD 502
            + +  L +  P               W+ E+   + T + G L     Y +TV      
Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISG-LTPETTYSVTVAAYTTK 803

Query: 503 GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTI 561
           G G+    K           PT+       N A+L+W   P     G +  Y + Y R  
Sbjct: 804 GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRAD 861

Query: 562 IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612
                 ++       +T++ L   T Y+ R+AA    G  +  E    TP+
Sbjct: 862 EARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 912



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 97/412 (23%), Positives = 152/412 (36%), Gaps = 59/412 (14%)

Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
           +S + + W  P   + ++  Y + Y T D+        +         TV  L P   Y 
Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485

Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
            R+      G G  S   +     T +  P++   F  +++ S T+    +QL W  LPP
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536

Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413
            E   +I+ YE+     +   Q + V     +     D    TL    L  +SD  V   
Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593

Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462
             TI A   Q+T      K          + V W  P  +S    I ++ V        D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516
           +   + D    +   H ++    L +   Y + V      GPG PES    ++       
Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFY-RTIIGNETAVNV---- 570
            PP K   V  + +      + W +LPV   Q+G IR Y + Y R   G    + +    
Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765

Query: 571 ----------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
                     +S   E T+S LT +T Y V +AAYT   +G +  P+   TT
Sbjct: 766 MLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 817



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
           P NL V      +S  +L W  P +  ++  I+ Y + +R  D ++  ++      +T +
Sbjct: 919 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 971

Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308
            FT+  LKP T Y  ++R     G G
Sbjct: 972 RFTLTGLKPDTTYDIKVRAWTSKGSG 997


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
           2 precursor [Homo sapiens]
          Length = 1898

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%)

Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278
           K  P PP +L V  +E  ++ + LTW + + + V    Y IQYR   A T       D  
Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369

Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338
           +T + +++  L PF+EY FR+  +   G+G     SE     T E  PS  P    +   
Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421

Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388
           +      T+ + W+  PP E NG +  Y V  T         W  H  +  +  T   L 
Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442
             +T   R LA   V +        V T   +PA   DFQA     ++++  +  + W+ 
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533

Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500
              P+E +  Y L +    D+       QQ   T   T  Y   +L     Y   +    
Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586

Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
             G G    +I+A   Q+ PS  P  V    +G     + W   P D +NG I  Y++ Y
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646

Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
             + G +   +V       H+ + L  L   T Y V + A+TD G   GPE
Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 87/400 (21%), Positives = 167/400 (41%), Gaps = 46/400 (11%)

Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281
           PP  +  ++    S+ ++++W  P   S   +I +Y++ Y   D     +   +  +   
Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666

Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338
           SS+ +  L+ +TEY   +R   + G G       E+S +   T ED PS  P    +++P
Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719

Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS---------------HLQNYTVN 383
            ++     V + WK   P + +G+I  Y+VT  R ++                 Q  T++
Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTIS 776

Query: 384 ATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
              LT   T    +A  T +    +S   ++T          P M +     +  L ++W
Sbjct: 777 G--LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMNTAL-LQW 831

Query: 444 TTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
             P+E    +  Y L++C   +  P   D+ ++D    + +    L +   Y+  +    
Sbjct: 832 HPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYIFRLAAKN 887

Query: 501 ADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559
             G G     +    +  PS  P  +    +  +   L WD   +  +NG I +YT+ +R
Sbjct: 888 RAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947

Query: 560 TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
            I   +   N+ ++ T +TL+ L  DT Y +++ A+T +G
Sbjct: 948 DINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 986



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 83/404 (20%), Positives = 147/404 (36%), Gaps = 49/404 (12%)

Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
           E  + ++L+W  P  + +I+ +  + +  +D     ++  + T    SS+T++DLKP T 
Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577

Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354
           Y F++    + G G ++   E     T +  PS  P     +    + G  TV++ W   
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630

Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400
           P    NG I  Y V                   + H     V   K T       Y   +
Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684

Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453
                VG   +++ + +   +   + P   ++  P ++  + V W  P  S     ++ Y
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744

Query: 454 ILEWCVLSDKAP----CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPES 509
            + +  L +  P     I D    +     T + G L     Y +TV      G G+   
Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEA--QETTISG-LTPETTYSVTVAAYTTKGDGARSK 801

Query: 510 IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568
            K           PT+       N A+L+W   P     G +  Y + Y R        +
Sbjct: 802 PKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRADEARPNTI 859

Query: 569 NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612
           +       +T++ L   T Y+ R+AA    G  +  E    TP+
Sbjct: 860 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 96/403 (23%), Positives = 151/403 (37%), Gaps = 50/403 (12%)

Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
           +S + + W  P   + ++  Y + Y T D+        +         TV  L P   Y 
Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485

Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
            R+      G G  S   +     T +  P++   F  +++ S T+    +QL W  LPP
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536

Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413
            E   +I+ YE+     +   Q + V     +     D    TL    L  +SD  V   
Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593

Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462
             TI A   Q+T      K          + V W  P  +S    I ++ V        D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516
           +   + D    +   H ++    L +   Y + V      GPG PES    ++       
Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709

Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFYRTIIGNETA---VNVD- 571
            PP K   V  + +      + W +LPV   Q+G IR Y + Y  +   E     +  D 
Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765

Query: 572 --SSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
             +   E T+S LT +T Y V +AAYT   +G +  P+   TT
Sbjct: 766 MLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
           P NL V      +S  +L W  P +  ++  I+ Y + +R  D ++  ++      +T +
Sbjct: 910 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 962

Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308
            FT+  LKP T Y  ++R     G G
Sbjct: 963 RFTLTGLKPDTTYDIKVRAWTSKGSG 988


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 134/595 (22%), Positives = 219/595 (36%), Gaps = 92/595 (15%)

Query: 104  NILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWD-------GGRETHLET 156
            N +  G   Q V G T  S +P   P N+S +      M   W         G     + 
Sbjct: 1179 NAIGSGPWSQTVVGRTRES-VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237

Query: 157  NFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINF-D 215
             +  K      +F   +         T       +V  EV V A   +G  +  H    +
Sbjct: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLT---GLGKYVLYEVQVLAFTRIGDGSPSHPPILE 1294

Query: 216  PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275
                  P PP  + ++  E  ++ ++L W  P+  + IIL Y I +R  + +T +    E
Sbjct: 1295 RTLDDVPGPP--MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL-NTTTANTATVE 1351

Query: 276  DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335
              A +   +T   LKP + Y+FRI      G   W + + EA  +T E R    P     
Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRITAQTRKG---WGE-AAEALVVTTEKRDRPQPPSRPM 1407

Query: 336  IDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWKSHLQNYTVNATKLTVN 390
            +     +  R+V L W+  P  +    +  Y     E+   RW  H  + + NA+   V+
Sbjct: 1408 VQQEDVRA-RSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVD 1464

Query: 391  LTND--RYLATLTVRNLVGKSD-----AAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
                   Y   +   N +G S+      ++ T+ A   +A   ++ +      ++L + W
Sbjct: 1465 RLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP-TILSVTPHTTTSVL-IRW 1522

Query: 444  TTPRESVKKYIL----------------------------EWCVLSD-------KAPCIT 468
              P E     IL                             W  L+          P +T
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582

Query: 469  DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRT 527
             ++ ++   HR Y            ++V     +GP SP   + ++ +A P+  P  V  
Sbjct: 1583 QYELDNLNKHRRYE---------IRMSVYNAVGEGPSSPPQ-EVFVGEAVPTAAPRNVVV 1632

Query: 528  KKVGKNEAVLEWDQLPVDVQNGFIRNYTI-FYRTIIGN--ETAVNVDSSHTEYTLSSLTS 584
                  +  + W+  P+D QNG I+ Y I F+    GN  E    +  +     L +LT 
Sbjct: 1633 HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692

Query: 585  DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAF--LLTTLLGV 637
             T YMV +AA+   G  DGP    +TP   Q +  A   P  + F  L TT + V
Sbjct: 1693 YTAYMVSVAAFNAAG--DGPR---STPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 118/529 (22%), Positives = 193/529 (36%), Gaps = 58/529 (10%)

Query: 109  GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHK 168
            GQ  ++   +++    P   P+N+       + +  +W    E+H   N  LK     + 
Sbjct: 674  GQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESH--QNGILKGYIIRYC 731

Query: 169  FADC------KAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK-VTSDHINFDPVYKVK 221
             A        K   D   +  +    + + N E+ V A N+ G  V S  +    +  V 
Sbjct: 732  LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791

Query: 222  PNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNI---QYRTKDASTWSQIPPED 276
              PP N+    +   S+ ++ TW  PS + +  I   Y +   +   ++  T     P  
Sbjct: 792  TVPPGNVHAEATN--STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNF 849

Query: 277  TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAP--SFWY 334
              S    F V  LK FTEY   + C    G G     S      T+ED P      SF  
Sbjct: 850  QDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDG---PRSTPQLVRTHEDVPGPVGHLSFSE 905

Query: 335  KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV-------TLTRWKSHLQNYTV--NAT 385
             +D S       +++ W+   P E NG +  Y +       T TR   +L N T+    T
Sbjct: 906  ILDTS-------LKVSWQ--EPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT 956

Query: 386  KLTVNLTNDRYLATLTVRNLVGKSDAAVLTI-----PACDFQATHPVMDLKAFPKDNMLW 440
             LT   T    +A +T +   G+   +  TI     P      T+  +         + +
Sbjct: 957  GLTALTTYTIEVAAMTSK---GQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF 1013

Query: 441  VEWTTPRESVKKYILE--WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTP 498
                  + S+ ++++E    V+ +    +   Q  +    R+    +L    CY   +  
Sbjct: 1014 RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQ 1073

Query: 499  VYADG--PGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRN-- 553
            V   G  P S  S K    QAPP   P  V  +   +    L W  LP    NG   +  
Sbjct: 1074 VNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133

Query: 554  YTIFYRTIIGNETAVN---VDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
            Y I Y    G+   ++    D    +YT+  L   T Y V++ A+   G
Sbjct: 1134 YKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 99/465 (21%), Positives = 168/465 (36%), Gaps = 72/465 (15%)

Query: 196  VWVEAENALGKVT-SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254
            V V+A NA+G    S  +       V  + P N+S + +   S +++ +    + ++ ++
Sbjct: 1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLV 1232

Query: 255  LKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
            L Y + Y+ KD+ T  +    +  S+RS+  +  L  +  Y  ++      G G  S   
Sbjct: 1233 LGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEVQVLAFTRIGDG--SPSH 1289

Query: 315  EEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK 374
                  T +D P   P          T    +V+L+W+  PP   NG IL Y++T     
Sbjct: 1290 PPILERTLDDVP--GPPMGILFPEVRT---TSVRLIWQ--PPAAPNGIILAYQIT----- 1337

Query: 375  SHLQNYTVNATKLTVNLTNDR------------YLATLTVRNLVGKSDAAVLTIPACDFQ 422
              L   T N   + V   + R            YL  +T +   G  +AA   +   + +
Sbjct: 1338 HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR 1397

Query: 423  -----ATHPVMDLKAFPKDNML--WVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475
                  + P++  +     ++L  W   +     V+ Y ++   L         W     
Sbjct: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR-----WALHSA 1452

Query: 476  TVHR---TYLRGNLAESKCYLITV--TPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKV 530
            +V     +++   L     Y   V  T    D   S ES      QA P + PT+ +   
Sbjct: 1453 SVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTP 1512

Query: 531  GKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI------------IGNETAVNVD------ 571
                +VL  W     D  NG +  + I YR +            I N  A   +      
Sbjct: 1513 HTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYS 1572

Query: 572  ------SSHTEYTLSSLTSDTLYMVRMAAY--TDEGGKDGPEFTF 608
                   S T+Y L +L     Y +RM+ Y    EG    P+  F
Sbjct: 1573 MRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVF 1617



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 99/435 (22%), Positives = 162/435 (37%), Gaps = 63/435 (14%)

Query: 225  PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDA--STWSQIPPE 275
            P N+S+  + E S  L L W        N + +SV    Y I+Y   D    T S +  +
Sbjct: 1100 PANVSLRTASETS--LWLRWMPLPEMEYNGNPESV---GYKIKYSRSDGHGKTLSHVVQD 1154

Query: 276  DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335
                    +T++DL+ +TEY  +++     G G    WS+   G T E  PS  P+    
Sbjct: 1155 ---RVERDYTIEDLEEWTEYRVQVQAFNAIGSG---PWSQTVVGRTRESVPSSGPTNVSA 1208

Query: 336  IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDR 395
            +  + +    ++ + W  +P  + NG +L Y+V      S  Q       +  +   N  
Sbjct: 1209 LATTSS----SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQ------PRFWLVEGNSS 1258

Query: 396  YLATLTVRNLVGKSDAAVLTIPAC-DFQATHP-----VMDLKAFPKDNMLWVEWTT---- 445
              A LT        +  VL      D   +HP      +D    P   +L+ E  T    
Sbjct: 1259 RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVR 1318

Query: 446  ----PRESVKKYILEWCVLS--DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPV 499
                P  +    IL + +    +     T   +      R Y    L     YL  +T  
Sbjct: 1319 LIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ 1378

Query: 500  YADGPGSPESIKAYL-------KQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552
               G G  E+ +A +       +  PPS+ P V+ + V     +L W+  P       +R
Sbjct: 1379 TRKGWG--EAAEALVVTTEKRDRPQPPSR-PMVQQEDVRARSVLLSWE--PGSDGLSPVR 1433

Query: 553  NYTIFYRTIIGNETAV---NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE--FT 607
             YTI  R +     A+   +V  + + + +  L   T Y  R+ A  D G  +  E   +
Sbjct: 1434 YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESES 1493

Query: 608  FTTPKFAQGEIEAIV 622
             TT + A  E   I+
Sbjct: 1494 LTTLQAAPDEAPTIL 1508



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 9/143 (6%)

Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
           P H ++ +++ E  +I  LTWT P   +  +++Y ++    +A     +   D  +T  S
Sbjct: 593 PEHPVATLSTVERRAI-NLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT--S 649

Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQG 343
            TV+ L P   Y FR+  + + GKG    +S++   ++  + P  AP     I    T  
Sbjct: 650 VTVKGLVPARSYQFRLCAVNDVGKG---QFSKDTERVSLPEEPPTAPP-QNVIASGRTN- 704

Query: 344 YRTVQLVWKTLPPFEANGKILDY 366
            +++ + W+  P    NG +  Y
Sbjct: 705 -QSIMIQWQPPPESHQNGILKGY 726



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 46/199 (23%), Positives = 77/199 (38%), Gaps = 11/199 (5%)

Query: 409 SDAAVLTIPACDFQATHPVMDLKAFPKD--NMLWVEWTTPRESVKKYILEWCVLSDKAPC 466
           S +A L +        HPV  L    +   N+ W +       + +YILE  +  + AP 
Sbjct: 579 SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE--MSENNAPW 636

Query: 467 ITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPG--SPESIKAYLKQAPPSKGPT 524
                  D       ++G L  ++ Y   +  V   G G  S ++ +  L + PP+  P 
Sbjct: 637 TVLLASVDPKATSVTVKG-LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695

Query: 525 VRTKKVGKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI---IGNETAVNVDSSHTEYTLS 580
                   N++++ +W   P   QNG ++ Y I Y      +G +     D+      L 
Sbjct: 696 NVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755

Query: 581 SLTSDTLYMVRMAAYTDEG 599
            L   T Y + +AAY   G
Sbjct: 756 DLIIWTNYEIEVAAYNSAG 774



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 10/91 (10%)

Query: 222  PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS----QIPPEDT 277
            P PP    ++     SS + + W++       I +Y I+ R  D   W      IP E +
Sbjct: 1825 PGPPGVPIIVR---YSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881

Query: 278  ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
            + T   F++  LKP   Y FR+  + + G G
Sbjct: 1882 SYT---FSMDILKPGVSYDFRVIAVNDYGFG 1909


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 123/493 (24%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 191  FVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
            FV  E+ V A   +G  V S  +  +      P PP  L V     L+S+ ++ W  P  
Sbjct: 1346 FVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSV-RIVWQPPEE 1403

Query: 250  KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
             + IIL Y I YR   +S  +    E  A+ R  FT  DL P + Y+FR+      G   
Sbjct: 1404 PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ-FTATDLAPESAYIFRLSAKTRQG--- 1459

Query: 310  WSDWSE--EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY- 366
               W E  EA+ IT E R   AP     +  +     R+++L W  +P  +    I  + 
Sbjct: 1460 ---WGEPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQW--VPGSDGASPIRYFT 1513

Query: 367  ----EVTLTRWKSHLQNYTVNATKLTVNLTND--RYLATLTVRNLVGKSDAAVLTIPACD 420
                E+    W+++  + +  AT   V+       Y   L   N +G SD +  T     
Sbjct: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573

Query: 421  FQAT--HPVMDLKAFPKD-NMLWVEWTTPRES-----VKKYILEWCVLSDKAPCITDW-- 470
             Q     P   + A P   + + ++W  PR+      ++ Y + +  L  +A   T+   
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633

Query: 471  -------------QQEDGTVHR--TYLRGNLAESKCY-----LITVTPVYADGPGSPESI 510
                         Q    TV+   T     L   K Y     ++T   +  + P S   +
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAP-V 1692

Query: 511  KAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568
            + ++ +A P+  P  V+   +  ++  + WD  P + QNG I+ Y I+Y      NET  
Sbjct: 1693 EVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK 1752

Query: 569  N--VDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVC 626
               +        L +LTS T Y+V ++A+   G  DGP+   + P+  +    A   P  
Sbjct: 1753 MKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAG--DGPK---SDPQQGRTHQAAPGAPSF 1807

Query: 627  LAF--LLTTLLGV 637
            LAF  + +T L V
Sbjct: 1808 LAFSEITSTTLNV 1820



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 86/402 (21%), Positives = 156/402 (38%), Gaps = 41/402 (10%)

Query: 222  PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTW----SQIPPEDT 277
            P+ P NL V  +   S  + L+W  P   +  IL Y ++  +++ S W    S + PE T
Sbjct: 668  PHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVEL-SENNSPWKVHLSNVGPEMT 726

Query: 278  ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
                   TV  L P   Y FR+  + E G+G    +S E S +   + P  AP    K  
Sbjct: 727  G-----VTVSGLTPARTYQFRVCAVNEVGRG---QYSAETSRLMLPEEPPSAPP---KNI 775

Query: 338  PSHTQGYRTVQLVWKTLPPFEANGKILDY--EVTLTRWKSHLQNYTVNATKLTVNLTNDR 395
             +  +  +++ + W+  P  E NG +  Y     L       Q   + + ++   L  D 
Sbjct: 776  VASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDL 835

Query: 396  YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNM---------LWVEWTTP 446
             + T     +   + A +        + T  +  +   P  N+         +   W  P
Sbjct: 836  IIWTQYEIQVAAYNGAGLGVFSRAVTEYT--LQGVPTAPPQNVQTEAVNSTTIQFLWNPP 893

Query: 447  RESVKKYI------LEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
             +     I      L W   + +A  +     +   VH  ++  NL +   Y  +V    
Sbjct: 894  PQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT-NLKKFTAYFTSVLCFT 952

Query: 501  ADGPGSPESIK-AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559
              G G P + +  + ++  P     +   ++      + W Q P++ +NG I  Y I + 
Sbjct: 953  TPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSW-QEPLE-KNGIITGYQISWE 1010

Query: 560  TIIGNETAV--NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
                N++ +   ++S+  EY +  L+S T Y + +AA T  G
Sbjct: 1011 VYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG 1052



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 122/527 (23%), Positives = 197/527 (37%), Gaps = 87/527 (16%)

Query: 125  PPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK--RDTPTSC 182
            P   PKN+       + +  +W    ET  E N  L+     ++ A    +  +   TS 
Sbjct: 768  PSAPPKNIVASGRTNQSIMVQWQPPPET--EHNGVLRGYILRYRLAGLPGEYQQRNITSP 825

Query: 183  TVDYSTV----YFVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELS 237
             V+Y  V     +   E+ V A N  G  V S  +    +  V   PP N   + +E ++
Sbjct: 826  EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQN---VQTEAVN 882

Query: 238  SI-LKLTWTNPSIKSV--IILKYNIQYRTKDAS---TWSQIPPEDTASTRSSFTVQDLKP 291
            S  ++  W  P  + +  I   Y +     DA    T   I P+         T  +LK 
Sbjct: 883  STTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT--NLKK 940

Query: 292  FTEYVFRIRCMKEDGKGYWSD----WSEEASGITYEDRPSKAP--SFWYKIDPSHTQGYR 345
            FT Y   + C    G G  S     W       T ED+P      SF   +D S      
Sbjct: 941  FTAYFTSVLCFTTPGDGPPSTPQLVW-------TQEDKPGAVGHLSFTEILDTS------ 987

Query: 346  TVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN-----YTVNATKLTVNLTNDRYLATL 400
             +++ W+   P E NG I  Y+++   W+ + +N     +T+N+T     +     L T 
Sbjct: 988  -LKVSWQE--PLEKNGIITGYQIS---WEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041

Query: 401  TVRNLVGKSDAAVLTIPACDFQATHPVM-----DLKAFPKDNMLWVEWTTPRE------- 448
            T+       D A +T        +  +      DL   P +  L +   +PR        
Sbjct: 1042 TI-------DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN--LVISNISPRSATLQFRP 1092

Query: 449  ------SVKKYILEWCV--LSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
                  S+ ++I+E  V  + D+   +T +++E+    +     NL     Y   +  V 
Sbjct: 1093 GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVN 1152

Query: 501  ADGPG--SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRN--YT 555
              GP   SP S      QAPP   PT V  +   +    L W  LP    NG   +  Y 
Sbjct: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYR 1212

Query: 556  I-FYRTIIGNETAVNV--DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
            I ++R+ + +     V  D    E+T+  L     Y ++M A+   G
Sbjct: 1213 IKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVG 1259



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 94/405 (23%), Positives = 154/405 (38%), Gaps = 45/405 (11%)

Query: 225  PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277
            P +++V  + E S  L+L W        N + +SV    Y I+Y   D  + S +    +
Sbjct: 1177 PTSVTVRTASETS--LRLRWVPLPDSQYNGNPESV---GYRIKYWRSDLQS-SAVAQVVS 1230

Query: 278  ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
                  FT+++L+ + EY  +++     G G    WSE   G T E  PS AP       
Sbjct: 1231 DRLEREFTIEELEEWMEYELQMQAFNAVGAG---PWSEVVRGRTRESVPSAAPENVSAEA 1287

Query: 338  PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL------TRWKSHL--QNYTVNATKLTV 389
             S TQ    + L W ++P  + NG IL Y++           +SH+   N+T +A    +
Sbjct: 1288 VSSTQ----ILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343

Query: 390  NLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE--WTTPR 447
                   L  L    +     +  L +      A  P + L  FP+  +  V   W  P 
Sbjct: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSVRIVWQPPE 1402

Query: 448  ES---VKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGP 504
            E    +  Y + + + S      T    E G   R +   +LA    Y+  ++     G 
Sbjct: 1403 EPNGIILGYQIAYRLASSSPHTFT--TVEVGATVRQFTATDLAPESAYIFRLSAKTRQGW 1460

Query: 505  GSP---ESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560
            G P     I    ++ P P +   V   +V      L+W  +P       IR +T+  R 
Sbjct: 1461 GEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW--VPGSDGASPIRYFTMQVRE 1518

Query: 561  IIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
            +   E    + ++    T   +  L   T Y +R+ A  D G  D
Sbjct: 1519 LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSD 1563



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 93/424 (21%), Positives = 158/424 (37%), Gaps = 64/424 (15%)

Query: 221  KPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
            +P PP  L V  +E  +  L+L W   S  +  I  + +Q R      W Q      +  
Sbjct: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEW-QTYSSSISHE 1534

Query: 281  RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI-TYEDRPSKAPSFWYKIDPS 339
             ++  V  L+PFT Y  R++   + G    SD+S E   + T +D P + P       P 
Sbjct: 1535 ATACVVDRLRPFTSYKLRLKATNDIGD---SDFSSETEAVTTLQDVPGEPPGS-VSATPH 1590

Query: 340  HTQGYRTVQLVWKTLPPFEANGKI---------LDYEVTLTRWKSHLQN-------YTVN 383
             T    +V + W+       NG +         L+YE         L+N        T  
Sbjct: 1591 TTS---SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647

Query: 384  ATKLTVNLTND-------------RYLATLTVRNLVGKSDA-AVLTIPACDFQATHPVMD 429
            ++  TVN ++              RY   +T  N++G+S A A + +   +        +
Sbjct: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707

Query: 430  LKAFP-KDNMLWVEW-TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYL----- 482
            ++  P   + L V W   P ES    I  + +   +A    D Q E   +   +L     
Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEA----DSQNETEKMKVLFLPEPVV 1763

Query: 483  -RGNLAESKCYLITVTPVYA--DGPGS-PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLE 538
               NL     YL++++   A  DGP S P+  + +  QA P     +   ++      + 
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH--QAAPGAPSFLAFSEITSTTLNVS 1821

Query: 539  WDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEY-TLSSLTSDTLYMVRM 592
            W +      NG ++ Y + Y  +     +     V V  +   +  +  LT    Y  R+
Sbjct: 1822 WGE--PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRV 1879

Query: 593  AAYT 596
             A T
Sbjct: 1880 QART 1883



 Score = 30.4 bits (67), Expect = 7.9
 Identities = 60/287 (20%), Positives = 109/287 (37%), Gaps = 53/287 (18%)

Query: 161  KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK--VTSDHINFDPVY 218
            + EW T+      +     T+C VD     F + ++ ++A N +G    +S+      + 
Sbjct: 1521 RGEWQTYS----SSISHEATACVVDRLRP-FTSYKLRLKATNDIGDSDFSSETEAVTTLQ 1575

Query: 219  KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRT------------- 263
             V   PP ++S   +   +S + + W  P  +S+  ++  Y I YR              
Sbjct: 1576 DVPGEPPGSVSA--TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633

Query: 264  --------KDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSE 315
                     + +  S     +++ST +   +  LK +  Y   +      G+   S  S 
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGE---SPASA 1690

Query: 316  EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS 375
                   E  P+ AP        + +Q    +++ W   PP   NG I  Y++    W++
Sbjct: 1691 PVEVFVGEAAPAMAPQNVQVTPLTASQ----LEVTWDPPPPESQNGNIQGYKIYY--WEA 1744

Query: 376  HLQNYTVNATKLTV--------NLT-NDRYLATLTVRNLVG---KSD 410
              QN T     L +        NLT + +YL +++  N  G   KSD
Sbjct: 1745 DSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791


>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
          Length = 629

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 61/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%)

Query: 78  QYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQN-VYGITIISGLPPEKPKNLSCIV 136
           Q T IN+T + + + +    +  + C        ++  + G  I SG PP+ P  ++C++
Sbjct: 76  QITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVI 135

Query: 137 NE-GKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIE 195
            E    M C W+ G+ T+++T + +       K  + + ++   TS  ++ ST      +
Sbjct: 136 YEYSGNMTCTWNAGKLTYIDTKYVVHV-----KSLETEEEQQYLTSSYINISTDSLQGGK 190

Query: 196 ---VWVEAENALGKVTSD--HINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
              VWV+A NALG   S    I+ D +             IN+    +I  + W + +  
Sbjct: 191 KYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTI--IYWDSQT-- 246

Query: 251 SVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW 310
           ++  +   ++Y+     TW+ +   DT  T    +   L+P  +YVF++RC +E GK YW
Sbjct: 247 TIEKVSCEMRYKATTNQTWN-VKEFDTNFTYVQQSEFYLEPNIKYVFQVRC-QETGKRYW 304

Query: 311 SDWS 314
             WS
Sbjct: 305 QPWS 308


>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
            sapiens]
          Length = 1183

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 131/577 (22%), Positives = 219/577 (37%), Gaps = 72/577 (12%)

Query: 204  LGKVTSDHINFDPVYKVK--PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
            +   T D ++   V  V   PNPP +L +  +++L   ++L+WT     +  I K+ I+Y
Sbjct: 611  VANTTLDSVSASAVLSVVDVPNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY 668

Query: 262  RTKDASTWSQIPPEDTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI 320
              +DA     +    T  + +  T Q  L P+  Y FR+  +   GK   S+ SE+   +
Sbjct: 669  --EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--L 724

Query: 321  TYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WK 374
            T    P K P+    ++   ++    V + WK L  FE+NG  L Y+V+  +      W 
Sbjct: 725  TKASEPDKNPT---AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWT 780

Query: 375  S----HLQNYTVNATKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVM 428
            S    ++  Y V+ T   V      YL  +   N +G     A V+     D     P  
Sbjct: 781  SVVVANVSKYIVSGTPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGN 835

Query: 429  DLKAFPKDNMLWVEW-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYL 482
                     +  V W   P +S++ +     I  W   S         +++  T   +  
Sbjct: 836  VRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKT 895

Query: 483  RG---NLAESKCYLITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537
             G    L     Y + V  V    +GP SP+ +     +  PS   +++      +   L
Sbjct: 896  HGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTL 954

Query: 538  EWDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRM 592
            EWD  P    NG +  YT+ Y+ I     +G    + + ++ T +TL +L   T Y    
Sbjct: 955  EWD--PPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYF 1012

Query: 593  AAYTDEG-GKDGPEFTFTTPKFAQGEIEAIV------VPVCLAFLLTTLLGVLFCFNKRD 645
             A T  G G    E   TT   A    +  +      + +  A  L  L+ ++ CF +R+
Sbjct: 1013 YAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRN 1072

Query: 646  LIKK---------HIWPNV-----PDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDV 691
               K         H  P +      D +    +    H P +    +          +D 
Sbjct: 1073 KGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDD 1132

Query: 692  SVVEIEANDKKPFPEDLKSLDLF--KKEKINTEGHSS 726
            S+V+        F ED   +  +  KKEK   EG+ S
Sbjct: 1133 SLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNES 1169


>gi|4506107 prolactin receptor [Homo sapiens]
          Length = 622

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 21/203 (10%)

Query: 124 LPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTL----KSEWATHKFADCKAKRDTP 179
           LPP KP+   C     +   C W  G +  L TN++L    + E   H+  D       P
Sbjct: 26  LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYIT--GGP 83

Query: 180 TSCTV--DYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLS--VINSEE 235
            SC     Y++++   I + V A N +G   SD +  D  Y V+P+PP  L+  V   E+
Sbjct: 84  NSCHFGKQYTSMWRTYI-MMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPED 142

Query: 236 LSSILKLTWTNPSIKSV----IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
               L + W+ P++  +      L Y I+ + + A+ W        A  ++ F +  L P
Sbjct: 143 RKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE----IHFAGQQTEFKILSLHP 198

Query: 292 FTEYVFRIRCMKEDGKGYWSDWS 314
             +Y+ ++RC  +   GYWS WS
Sbjct: 199 GQKYLVQVRCKPD--HGYWSAWS 219


>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
            sapiens]
          Length = 1304

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 108/444 (24%), Positives = 177/444 (39%), Gaps = 57/444 (12%)

Query: 216  PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275
            PVY V PNPP +L +  +++L   ++L+WT     +  I K+ I+Y  +DA     +   
Sbjct: 642  PVYDV-PNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY--EDAMHKPGLWHH 696

Query: 276  DTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY 334
             T  + +  T Q  L P+  Y FR+  +   GK   S+ SE+   +T    P K P+   
Sbjct: 697  QTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--LTKASEPDKNPT--- 751

Query: 335  KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WKS----HLQNYTVNA 384
             ++   ++    V + WK L  FE+NG  L Y+V+  +      W S    ++  Y V+ 
Sbjct: 752  AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSG 810

Query: 385  TKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE 442
            T   V      YL  +   N +G     A V+     D     P           +  V 
Sbjct: 811  TPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVH 865

Query: 443  W-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYLRG---NLAESKCYL 493
            W   P +S++ +     I  W   S         +++  T   +   G    L     Y 
Sbjct: 866  WDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYT 925

Query: 494  ITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFI 551
            + V  V    +GP SP+ +     +  PS   +++      +   LEWD  P    NG +
Sbjct: 926  LNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPSHPNGIL 982

Query: 552  RNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPE 605
              YT+ Y+ I     +G    + + ++ T +TL +L   T Y     A T  G G    E
Sbjct: 983  TEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042

Query: 606  FTFTT--------PKFAQGEIEAI 621
               TT        P    G+++A+
Sbjct: 1043 EAVTTVDEAGILPPDVGAGKVQAV 1066



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 151/791 (19%), Positives = 277/791 (35%), Gaps = 128/791 (16%)

Query: 23   ELLDPCGYIS-PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTI 81
            E+ DP   +  PE  VVQ  S  +  C +K       H  +  ++W  ++  +P ++   
Sbjct: 541  EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD-----HTLSLTVLWLKDNRELPSDERFT 595

Query: 82   INR--------------TASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPE 127
            +++              T + V  T + S++     +++        VY +       P 
Sbjct: 596  VDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDV-------PN 648

Query: 128  KPKNLSCIVNEGKKMRCEWDGGRETHLE-TNFTLKSEWATHKFADCKAKRDTP-TSCTVD 185
             P +L       K ++  W  G + +   T F ++ E A HK      + +   T  T  
Sbjct: 649  PPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQ 708

Query: 186  YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWT 245
                 +VN    V A N++GK      +   + K      +  +V         L +TW 
Sbjct: 709  LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK 768

Query: 246  --NPSIKSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCM 302
              N    +   L+Y + +R KD    W+ +      +  S + V     F  Y+ +++ +
Sbjct: 769  PLNGFESNGPGLQYKVSWRQKDGDDEWTSV----VVANVSKYIVSGTPTFVPYLIKVQAL 824

Query: 303  KEDGKGYWSDWSEEASGITYEDRPSKAPS--------------FW----YKIDPSHTQGY 344
             + G   ++       G + ED P  AP                W     K    H QGY
Sbjct: 825  NDMG---FAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGY 881

Query: 345  RTVQLVWKTLPPFEANGKILDYEV-TLTRWKSH--------LQNYTVNATKLTVNLTNDR 395
            R     WKT    + N + ++ ++ T    K+H          +YT+N     V + N +
Sbjct: 882  RIYY--WKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLN-----VRVVNGK 934

Query: 396  YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRES---VKK 452
                 +  + V  +   V + P+   +  +P +D         L +EW  P      + +
Sbjct: 935  GEGPASP-DRVFNTPEGVPSAPS-SLKIVNPTLD--------SLTLEWDPPSHPNGILTE 984

Query: 453  YILEWCVLS---DKAPCI--------TDWQQED---GTVHRTYLRGNLAESKCYLIT--- 495
            Y L++  ++   +  P +        T W  ++    T ++ Y     +      IT   
Sbjct: 985  YTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEA 1044

Query: 496  VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
            VT V   G   P+     ++   P       T    +  A + W+    +  N ++    
Sbjct: 1045 VTTVDEAGILPPDVGAGKVQAVNPRISNL--TAAAAETYANISWEYEGPEHVNFYVEYGV 1102

Query: 556  IFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQ 615
               +     E    V+ S + + L  L   T Y VR+ A  D G     +   T P  A 
Sbjct: 1103 AGSKEEWRKEI---VNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMAS 1159

Query: 616  GEIEAIV----VPVCLAFLLTTLLGVLFCFNKRDLIKK---------HIWPNV-----PD 657
             +++       + +  A  L  L+ ++ CF +R+   K         H  P +      D
Sbjct: 1160 RQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDD 1219

Query: 658  PSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLF--K 715
             +    +    H P +    +          +D S+V+        F ED   +  +  K
Sbjct: 1220 GTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGK 1279

Query: 716  KEKINTEGHSS 726
            KEK   EG+ S
Sbjct: 1280 KEKEPAEGNES 1290


>gi|22212918 ciliary neurotrophic factor receptor preproprotein
           [Homo sapiens]
          Length = 372

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%)

Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
           GLPP +P  LSC  N   K   C W     T++   F +     + K   C+        
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163

Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           C + Y  ++  +  +V +   NALG   +  I FD    VKP+PP N+           L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222

Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
           ++TW  PS         LK+ ++YR      W  +   D     ++ T+ D     EY+ 
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278

Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326
           ++   K++  G WSDWS  A    + + P
Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306


>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
           sapiens]
          Length = 372

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%)

Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
           GLPP +P  LSC  N   K   C W     T++   F +     + K   C+        
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163

Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
           C + Y  ++  +  +V +   NALG   +  I FD    VKP+PP N+           L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222

Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
           ++TW  PS         LK+ ++YR      W  +   D     ++ T+ D     EY+ 
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278

Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326
           ++   K++  G WSDWS  A    + + P
Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 133/570 (23%), Positives = 211/570 (37%), Gaps = 63/570 (11%)

Query: 70    NHFTIPKEQYTIINRTASSVTFTDIASLNIQLTC----NILTFGQLEQNVYGI--TIISG 123
             +H+ I K + + ++ T  S   T++ +LN ++T     N   F  +  N YGI   + SG
Sbjct: 24835 SHYIIEKRETSRLSWTQVS---TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESG 24891

Query: 124   --------LPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFA 170
                      PP  P            M   W     DGG  T +E     K +    ++ 
Sbjct: 24892 PVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGG--TEIEGYILEKRDKEGVRWT 24949

Query: 171   DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENA--LGKVTSDHINF---DPVYKVKPNPP 225
              C  K  T     V   T    + E  V AENA  +G+ +   + +   D +Y   P PP
Sbjct: 24950 KCNKKTLTDLRLRVTGLTEGH-SYEFRVAAENAAGVGEPSEPSVFYRACDALYP--PGPP 25006

Query: 226   HNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTASTRSSF 284
              N  V ++   S  + L W+ P       +K Y ++ +   A  W+   P  T      F
Sbjct: 25007 SNPKVTDTSRSS--VSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP-TGLQGKQF 25063

Query: 285   TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEAS--GITYEDRPSKAPSFWYKIDPSHTQ 342
             TV  LK  TEY FRI  +  +G G      E A+  G        + P      D     
Sbjct: 25064 TVTKLKENTEYNFRICAINSEGVG------EPATLPGSVVAQERIEPPEIELDADLRKVV 25117

Query: 343   GYR---TVQL--VWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397
               R   T++L    K  P  E   +  +  +T         ++T+          + RY 
Sbjct: 25118 VLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRY- 25176

Query: 398   ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKY 453
               LT+ N  G S  A + +   D  +    + ++   KD++  + W  P       +  Y
Sbjct: 25177 -NLTLENNSG-SKTAFVNVRVLDSPSAPVNLTIREVKKDSVT-LSWEPPLIDGGAKITNY 25233

Query: 454   ILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSP-ESIKA 512
             I+E    + KA         +     T+   NL E   Y   V      G G P E+ + 
Sbjct: 25234 IVEKRETTRKAYATI----TNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEP 25289

Query: 513   YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDS 572
                  PP     V    V +N A ++W++ P       I  Y +  +T    + +     
Sbjct: 25290 VKVSEPPLPPGRVTLVDVTRNTATIKWEK-PESDGGSKITGYVVEMQTKGSEKWSTCTQV 25348

Query: 573   SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
                E T+S LT+   Y+ R+AA  ++G  D
Sbjct: 25349 KTLEATISGLTAGEEYVFRVAAVNEKGRSD 25378



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 115/452 (25%), Positives = 173/452 (38%), Gaps = 58/452 (12%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELS-SILKLTWTNPSIKSVI 253
             E  V AENA G   +  I+     +   NPP   +V+   + S + + L W+ P     +
Sbjct: 28224 EFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGM 28283

Query: 254   -ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312
              I+ Y I+    D   W ++  E    TR  +TV DL+   EY FR+  +   GKG   D
Sbjct: 28284 EIIGYIIEMCKADLGDWHKVNAEACVKTR--YTVTDLQAGEEYKFRVSAINGAGKG---D 28338

Query: 313   WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKILDYE 367
               E    I   DR + AP      +   T   R      + + ++  P   A     D  
Sbjct: 28339 SCEVTGTIKAVDRLT-APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSN 28397

Query: 368   VTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPV 427
             ++L R   H  +     T    N  ND    TLTV N  G S +   T+   D       
Sbjct: 28398 LSL-RADIHTTDSFSTLTVENCN-RNDAGKYTLTVENNSG-SKSITFTVKVLDTPGPPGP 28454

Query: 428   MDLKAFPKDNMLWVEWTTP----RESVKKYILE--------WCVLSDKAPCITDWQQEDG 475
             +  K   + +   + W  P       +  Y++E        W V+S+K            
Sbjct: 28455 ITFKDVTRGSAT-LMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKC----------- 28502

Query: 476   TVHRTYLRGNLAESKCYLITVTPVYADGPGS----PESIKAYLKQAPPSKGPTVRTKKVG 531
                + +   +LAE   Y   V+ V   G G     PE I A  + APP +   V T    
Sbjct: 28503 -TRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---S 28558

Query: 532   KNEAVLEWDQLPVDVQNGF-IRNYTIFYRTIIGNETAVNVDSSHTE---YTLSSLTSDTL 587
             K+ AVL W  L  D   G  I  Y +  R      +   V++ HT+   +T+  L   T 
Sbjct: 28559 KSSAVLAW--LKPDHDGGSRITGYLLEMRQ---KGSDFWVEAGHTKQLTFTVERLVEKTE 28613

Query: 588   YMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE 619
             Y  R+ A  D G  + P   F++    + +IE
Sbjct: 28614 YEFRVKAKNDAGYSE-PREAFSSVIIKEPQIE 28644



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 100/407 (24%), Positives = 147/407 (36%), Gaps = 49/407 (12%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
             P PP +L V  S+      +L+W  P       +K Y I+ RT D   W+++ P+  ++T
Sbjct: 15912 PGPPKDLKV--SDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTT 15969

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
                F V DL    +Y FR+R     G G      E     T  D P   P    K+    
Sbjct: 15970 ---FVVPDLLSEQQYFFRVRAENRFGIG---PPVETIQRTTARD-PIYPPDPPIKLKIGL 16022

Query: 341   TQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK---------SHLQNYTVNATKLTVN- 390
                  TV L WK  P  +    +  Y V    W                 V   + TV  
Sbjct: 16023 IT-KNTVHLSWKP-PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 16080

Query: 391   -LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH--PVMDLKAFPK-DNMLWVEWTTP 446
              +    Y   +   N  G S  +  T+  CD Q     P +DLK F + +    V     
Sbjct: 16081 LVEGGEYEFRVKAVNAAGVSKPSA-TVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAK 16139

Query: 447   RESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------ 494
              + V    L W     K P       ++  ++ T++   + +  C L+            
Sbjct: 16140 IKGVPFPTLTWFKAPPKKP-----DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194

Query: 495   TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
             T+T V   G  S E     L +  P  GP ++ + V  ++  L W   P D     I NY
Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGP-IKFESVSADQMTLSWFP-PKDDGGSKITNY 16252

Query: 555   TIFYRTIIGNETAVNVDSSHTE--YTLSSLTSDTLYMVRMAAYTDEG 599
              I  R     +T V+V S   E  YT+  L     Y+ R+ A    G
Sbjct: 16253 VIEKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYG 16298



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 139/610 (22%), Positives = 219/610 (35%), Gaps = 94/610 (15%)

Query: 77    EQYTIINRTASSVTFTDIASLNIQLTC---------NILTFGQLEQNVYGI--------- 118
             + Y +  R  S + +T++AS  +Q+T          N   F  +  N YG+         
Sbjct: 21588 DHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPV 21646

Query: 119   -TIISGLPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTL-KSEWATHKFAD 171
               +    PP+ PKN          M   W     DGG E     N+ + + + A  ++  
Sbjct: 21647 LAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI---INYIVERRDKAGQRWIK 21703

Query: 172   CKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV-----KPNPPH 226
             C  K  T     V   T      E  + AENA G   S      P YK      KP PP 
Sbjct: 21704 CNKKTLTDLRYKVSGLTEGH-EYEFRIMAENAAG--ISAPSPTSPFYKACDTVFKPGPPG 21760

Query: 227   NLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQI-PPEDTASTRSSF 284
             N  V+++   S  + + W  P       I  Y ++    +   W  + PP    +T  S+
Sbjct: 21761 NPRVLDTSRSS--ISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT--SY 21816

Query: 285   TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGY 344
             T+  L    EY  RI  M  +G G          G    +     P      D       
Sbjct: 21817 TITGLTENQEYKIRIYAMNSEGLGE----PALVPGTPKAEDRMLPPEIELDADLRKVVTI 21872

Query: 345   RT-------VQLVWKTLPPFE---ANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTN- 393
             R        V +  +  P  +    +G+ LD        K+ +++ T + T L V   N 
Sbjct: 21873 RACCTLRLFVPIKGRPAPEVKWARDHGESLD--------KASIES-TSSYTLLIVGNVNR 21923

Query: 394   -DRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RE 448
              D     LTV N  G S +A + +   D       + +K   K ++  + W  P      
Sbjct: 21924 FDSGKYILTVENSSG-SKSAFVNVRVLDTPGPPQDLKVKEVTKTSVT-LTWDPPLLDGGS 21981

Query: 449   SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKC-YLITVTPVYADGPGSP 507
              +K YI+E    + KA     +       H+T  + +  +  C Y   V      G G P
Sbjct: 21982 KIKNYIVEKRESTRKA-----YSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLP 22036

Query: 508   ----ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIG 563
                 ES+KA  +  PP K   +    V +N   L W++ P       I  Y +  +T   
Sbjct: 22037 AETAESVKASERPLPPGK---ITLMDVTRNSVSLSWEK-PEHDGGSRILGYIVEMQTKGS 22092

Query: 564   NETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVV 623
             ++ A       TE T++ L     Y  R++A  ++G  D  +   + P  A+     +V+
Sbjct: 22093 DKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ--LSVPVIAKD----LVI 22146

Query: 624   PVCLAFLLTT 633
             P     L  T
Sbjct: 22147 PPAFKLLFNT 22156



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 102/436 (23%), Positives = 167/436 (38%), Gaps = 54/436 (12%)

Query: 195   EVWVEAENALG----KVTSDHINF-DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
             E  V AENA G      TS  I   DPV+   P+PP    +++S + +  + + W  P  
Sbjct: 26054 EYRVYAENAAGLSLPSETSPLIRAEDPVFL--PSPPSKPKIVDSGKTT--ITIAWVKPLF 26109

Query: 250   KS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSS-FTVQDLKPFTEYVFRIRCMKEDGK 307
                  I  Y ++Y+  D + W         S R + +T+  L    EYVFR++ + + G 
Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKT----SIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 26165

Query: 308   GYWSDWSEEASGITYEDRP------SKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG 361
                SD S+       E+ P          +   K   S T    TV    + +P      
Sbjct: 26166 SDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTM---TVPFRGRPVP-----N 26217

Query: 362   KILDYEVTLTRWKSHLQNYTVNATKLTVNLT--NDRYLATLTVRNLVGKSDAAVLTIPAC 419
              +     T  R ++++   T + T LT+     ND    TLT++N++  + +  L +   
Sbjct: 26218 VLWSKPDTDLRTRAYVDT-TDSRTSLTIENANRNDSGKYTLTIQNVLSAA-SLTLVVKVL 26275

Query: 420   DFQATHPVMDLKAFPKDNMLWVEWTTPRES----VKKYILEWCVLSDKAPCITDWQQEDG 475
             D       + ++   K++ + + W  P       VK Y +E    S KA     W     
Sbjct: 26276 DTPGPPTNITVQDVTKESAV-LSWDVPENDGGAPVKNYHIEKREASKKA-----WVSVTN 26329

Query: 476   TVHR-TYLRGNLAESKCYLITVTPVYADGPGSP----ESIKAYLKQAPPSKGPTVRTKKV 530
               +R +Y   NL E   Y   V+     G G P    E +K   K +PP K   +    +
Sbjct: 26330 NCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEK---LGVTSI 26386

Query: 531   GKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-VDSSHTEYTLSSLTSDTLYM 589
              K+   L W  L  +   G    + +      G +  V    +  T + +S L  ++ Y 
Sbjct: 26387 SKDSVSLTW--LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYF 26444

Query: 590   VRMAAYTDEGGKDGPE 605
              R+ A    G  D  E
Sbjct: 26445 FRVFAENQAGLSDPRE 26460



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 73/261 (27%), Positives = 103/261 (39%), Gaps = 40/261 (15%)

Query: 198   VEAENALGKVTSDHINFDPVYKVK-----PNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
             V A N +G  T + +  D   + +     P PP N+++ +       + LTW  P     
Sbjct: 13164 VSARNRVG--TGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFG--VSLTWEPPEYDGG 13219

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRS----SFTVQDLKPFTEYVFRIRCMKEDGK 307
               I  Y I+ R K +  W      DTA T      S TV D+    EY FR+R     G 
Sbjct: 13220 AEITNYVIELRDKTSIRW------DTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGV 13273

Query: 308   GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGK-ILDY 366
             G  S  +         +RPS   +       S  Q   +VQL W+  PP +  G  IL Y
Sbjct: 13274 GKPSAATPFVKVADPIERPSPPVNL-----TSSDQTQSSVQLKWE--PPLKDGGSPILGY 13326

Query: 367   EVTLTRWKSHLQNYTVNATKLTVNLT--------NDRYLATLTVRNLVGKSDAAVLTIP- 417
                + R +    N+     KL   LT         ++YL  ++  N  G SD + +  P 
Sbjct: 13327 --IIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPL 13384

Query: 418   ACDFQATHPVMDLKAFPKDNM 438
               D     P MDL AF KD +
Sbjct: 13385 TADDAFVEPTMDLSAF-KDGL 13404



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 98/420 (23%), Positives = 159/420 (37%), Gaps = 36/420 (8%)

Query: 198   VEAENALGKVT-SDHINF----DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
             V A NA G    S+  NF    +P Y   P PP    V+++ + S  + L WT P     
Sbjct: 29315 VTAVNAAGNSEPSEASNFISCREPSYT--PGPPSAPRVVDTTKHS--ISLAWTKPMYDGG 29370

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
               I+ Y ++ + KD   W ++    T    + FTV DLK   +Y FR+  +   G    S
Sbjct: 29371 TDIVGYVLEMQEKDTDQWYRVHTNATIRN-TEFTVPDLKMGQKYSFRVAAVNVKG---MS 29426

Query: 312   DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT 371
             ++SE  + I   +R  + P      D   T   R    +   +        ++ +     
Sbjct: 29427 EYSESIAEIEPVER-IEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGI 29485

Query: 372   RWKSHLQNYTVNATKLTVNLTNDRYLA---TLTVRNLVGKSDAAVLTIPACDFQATHPVM 428
                S     T  +  L +    +RY A   T+   N  GK  A VL +   D     P +
Sbjct: 29486 DLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVL-VKVYDTPGPCPSV 29544

Query: 429   DLKAFPKDNMLWVEWTTPR----ESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR- 483
              +K   +D++  + W  P       V  YI+E      +   +  ++       +T  R 
Sbjct: 29545 KVKEVSRDSVT-ITWEIPTIDGGAPVNNYIVE-----KREAAMRAFKTVTTKCSKTLYRI 29598

Query: 484   GNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542
               L E   Y   V P    G G P E+  A L    P     +    V K+   L W++ 
Sbjct: 29599 SGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK- 29657

Query: 543   PVDVQNGFIRNYTIFYRTIIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
             P+      +  Y +      G E     V +  +  E+T++SL     Y+ R+ A  ++G
Sbjct: 29658 PLYDGGSRLTGY-VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 29716



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 99/421 (23%), Positives = 165/421 (39%), Gaps = 46/421 (10%)

Query: 201   ENALGKVTSDHINFDPVYKV--KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKY 257
             EN+ GK       +  V KV   P PP N++V    + S+ +  TW  P I     I+ Y
Sbjct: 19769 ENSCGKK-----EYTIVVKVLDTPGPPVNVTVKEISKDSAYV--TWEPPIIDGGSPIINY 19821

Query: 258   NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317
              +Q R  +  +WS +  E    +++SF V +L+    Y FR+    E G G   D  E  
Sbjct: 19822 VVQKRDAERKSWSTVTTE---CSKTSFRVANLEEGKSYFFRVFAENEYGIG---DPGETR 19875

Query: 318   SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL----TRW 373
               +     P   P    K+    +    +  + WK  P  +   +I+ Y V       +W
Sbjct: 19876 DAVKASQTP--GPVVDLKV---RSVSKSSCSIGWKK-PHSDGGSRIIGYVVDFLTEENKW 19929

Query: 374   KSHLQNYTV--NATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLK 431
             +  +++ ++  +A  LT       Y   ++  N  G+   + +T+ A D     P +DLK
Sbjct: 19930 QRVMKSLSLQYSAKDLT---EGKEYTFRVSAENENGEGTPSEITVVARD-DVVAPDLDLK 19985

Query: 432   AFP------KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN 485
               P      K+N  +     P +      + W    D     T    E   V+ T +  +
Sbjct: 19986 GLPDLCYLAKENSNF-RLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYD 20044

Query: 486   LAESKC--YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLP 543
               +S    Y IT+  V     G+  SIK   K   P+ GP ++  +V      L+W   P
Sbjct: 20045 CQKSDAGKYTITLKNVAGTKEGT-ISIKVVGKPGIPT-GP-IKFDEVTAEAMTLKWAP-P 20100

Query: 544   VDVQNGFIRNYTIFYRTIIGNETAVNVDS-SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
              D     I NY +  R  + N+      +   T + ++ L     Y  R++A    G  +
Sbjct: 20101 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 20160

Query: 603   G 603
             G
Sbjct: 20161 G 20161



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 95/411 (23%), Positives = 150/411 (36%), Gaps = 64/411 (15%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
             P PP NL+V    + S+ L   W  P I     +K Y I  R      ++ +    +  +
Sbjct: 24116 PGPPQNLAVKEVRKDSAFL--VWEPPIIDGGAKVKNYVIDKRESTRKAYANV---SSKCS 24170

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
             ++SF V++L     Y FR+    E G G       E         P   P      D S 
Sbjct: 24171 KTSFKVENLTEGAIYYFRVMAENEFGVGV----PVETVDAVKAAEPPSPPGKVTLTDVSQ 24226

Query: 341   TQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTVNATKLTVNLTNDR 395
             T    +  L+W+  P  +   ++L Y V +      +W    ++   NA  +T   +   
Sbjct: 24227 T----SASLMWEK-PEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV-VTGLSSGQE 24280

Query: 396   YLATLTVRNLVGKSDAAVLTIPACDFQAT-HPVM-------------DLK------AFPK 435
             Y   +   N  GKSD  VL +P      T  P +             DLK        P+
Sbjct: 24281 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR 24340

Query: 436   DNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLI 494
              N+ WV+   P +   +  +E                E  T    +++ GN  +   Y  
Sbjct: 24341 PNISWVKDGEPLKQTTRVNVE----------------ETATSTVLHIKEGNKDDFGKY-- 24382

Query: 495   TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
             TVT   + G  +       L++  P  GP VR  +V  +  V+ W+  P       I NY
Sbjct: 24383 TVTATNSAGTATENLSVIVLEKPGPPVGP-VRFDEVSADFVVISWEP-PAYTGGCQISNY 24440

Query: 555   TIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGP 604
              +  R T       V+   + T   ++ L + T Y  R+ A  +  GK  P
Sbjct: 24441 IVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFA-ENRYGKSAP 24490



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 80/358 (22%), Positives = 137/358 (38%), Gaps = 50/358 (13%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAST 280
             P P  +L V  S+   +   ++W  P       +  Y ++ R  D  TWS + PE     
Sbjct: 18699 PGPVSDLKV--SDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPE---VK 18753

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
             ++SF V +L P  EY FR+  + E G G  +D  +          P   P    K++ + 
Sbjct: 18754 KTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKP----VLASDPLSEPDPPRKLEVTE 18809

Query: 341   TQGYRTVQLVWKTLPPFEANGKILDYEVT--------LTRWKSH--LQNYTVNATKLTVN 390
                  +  L W  LPP    G  +D  +T          RW  +  +++ ++  T L   
Sbjct: 18810 -MTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLK-- 18864

Query: 391   LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV 450
                 +Y   +  RN VG      +++P  + +  +   +    PK  +L  E  T +   
Sbjct: 18865 -EGKKYKFRVAARNAVG------VSLPR-EAEGVYEAKEQLLPPK--ILMPEQITIKAG- 18913

Query: 451   KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------TVTP 498
             KK  +E  V     P     + ED  V  ++L  + A+S   LI            ++T 
Sbjct: 18914 KKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTA 18973

Query: 499   VYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTI 556
               + G  + + IK  +  AP    P      +  +   L W  +P++     I NY +
Sbjct: 18974 ENSSGTDT-QKIKVVVMDAPGPPQPPFDISDIDADACSLSW-HIPLEDGGSNITNYIV 19029



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 65/276 (23%), Positives = 111/276 (40%), Gaps = 35/276 (12%)

Query: 149   GRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVT 208
             G+E       T+K++  +       A  + P S   D + +Y + +E      N LG  T
Sbjct: 14424 GKEVKASDRLTMKNDHIS-------AHLEVPKSVRAD-AGIYTITLE------NKLGSAT 14469

Query: 209   SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDAS 267
             +  IN   +    P P  ++    S+   S  KLTW  P       IL Y ++ R     
Sbjct: 14470 AS-INVKVIGL--PGPCKDIKA--SDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR 14524

Query: 268   TWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPS 327
             T+    P  +   + S+TV+DL P  EY FR++ + + G G   ++ E  + +  +D P 
Sbjct: 14525 TYI---PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGG---EYIELKNPVIAQD-PK 14577

Query: 328   KAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTV 382
             + P     ++  H      + + WK  P ++   KI+ Y +        RWK   ++   
Sbjct: 14578 QPPDPPVDVE-VHNPTAEAMTITWKP-PLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 14635

Query: 383   NATKLTVNLTNDR-YLATLTVRNLVGKSDAAVLTIP 417
               T     L   + Y   +   N  G S+ +  T P
Sbjct: 14636 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 72/342 (21%), Positives = 136/342 (39%), Gaps = 44/342 (12%)

Query: 221   KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
             +P PP  L V+++ + S++L   W  P       I  Y ++ R K +  W     E   +
Sbjct: 28545 QPAPPRRLDVVDTSKSSAVL--AWLKPDHDGGSRITGYLLEMRQKGSDFWV----EAGHT 28598

Query: 280   TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339
              + +FTV+ L   TEY FR++   + G   +S+  E  S +  ++          +I+P+
Sbjct: 28599 KQLTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEP---------QIEPT 28646

Query: 340   HTQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNAT-KLTVNLTNDRYL 397
                   T QL+  K   PF  +  I         WK  L+   +  T ++++  T DR  
Sbjct: 28647 ADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWK--LEEMRLKETDRVSITTTKDRTT 28704

Query: 398   AT-------------LTVRNLVG-KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
              T             LT+ N  G K+ +  + +       T P+ ++ +   ++ + + W
Sbjct: 28705 LTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPI-EVSSVSAESCV-LSW 28762

Query: 444   TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYAD 502
               P++     I  + ++  +    T WQ  + +V RT ++  +L +   Y   V+     
Sbjct: 28763 GEPKDGGGTEITNY-IVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRF 28821

Query: 503   GPGSPESIKAYLKQ---APPSKGPTVRTKKVGKNEAVLEWDQ 541
             G   P      + +    PPS         V  N   + W++
Sbjct: 28822 GVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEE 28863



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 94/374 (25%), Positives = 145/374 (38%), Gaps = 39/374 (10%)

Query: 241   KLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRI 299
             KLTW +P       I  Y I+ R  D   W+   P     TR + TVQ L     Y FRI
Sbjct: 16634 KLTWFSPEDDGGSPITNYVIEKRESDRRAWT---PVTYTVTRQNATVQGLIQGKAYFFRI 16690

Query: 300   RCMKEDGKGYWSDWSEE---ASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
                   G G + + SE       IT  +RP                   TV L W   P 
Sbjct: 16691 AAENSIGMGPFVETSEALVIREPITVPERPEDL--------EVKEVTKNTVTLTWNP-PK 16741

Query: 357   FEANGKILDYEV---TLTRWKSH-LQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSD 410
             ++   +I++Y +    +   K H + N  + + K TV      D Y   ++  N+VG+  
Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGK 16801

Query: 411   AAVLTIP-ACDFQATHPVMDLKAFPKDNMLWVE--WTTPRESVK-KYILEWCVLSDKAPC 466
              +  T P  C  +   P + L    K  +   E    T R S K K  + W    D+A  
Sbjct: 16802 PSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSW--FKDEADV 16859

Query: 467   ITDWQQEDGTVHRTY----LRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKG 522
             + D +    T   T     ++   ++S  Y + V        G  + +    +  PP  G
Sbjct: 16860 LEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQ-VNVVDRPGPP-VG 16917

Query: 523   PTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYT--LS 580
             P V   +V K+  V+ W + P+D     I NY I  +  +G +  + V S+  + T  +S
Sbjct: 16918 P-VSFDEVTKDYMVISW-KPPLDDGGSKITNY-IIEKKEVGKDVWMPVTSASAKTTCKVS 16974

Query: 581   SLTSDTLYMVRMAA 594
              L     Y+ R+ A
Sbjct: 16975 KLLEGKDYIFRIHA 16988



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 47/184 (25%), Positives = 76/184 (41%), Gaps = 22/184 (11%)

Query: 164   WATHKFAD-CKAKRDTP---TSCTVDYSTVYFVNIE------VWVEAENALGKVTSDHIN 213
             W T+   + C+AK        S  +  +T   VN+         V A+N  G   SD + 
Sbjct: 30754 WITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFG--ISDPLE 30811

Query: 214   FDPVYKVKPNPPHNLSVINSEELSSILK----LTWTNP-SIKSVIILKYNIQYRTKDAST 268
                V  +K +P           ++++ K    + W  P S     I  Y ++ R K  + 
Sbjct: 30812 VSSVVIIK-SPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNK 30870

Query: 269   WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSK 328
             W  +  E+   T   F+V++L    EY FR++C    G+  WS+ SE  +     D P +
Sbjct: 30871 WISVTTEEIRET--VFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT--PKSDVPIQ 30926

Query: 329   APSF 332
             AP F
Sbjct: 30927 APHF 30930



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 94/374 (25%), Positives = 139/374 (37%), Gaps = 63/374 (16%)

Query: 215   DPVYKVKP-NPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQI 272
             +PV  + P +PP    VIN    S  + L WT P       L  Y ++ R   + +W + 
Sbjct: 20266 EPVVALDPIDPPGKPEVINITRNS--VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKA 20323

Query: 273   PPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSF 332
                +      +FTV DL    +Y FRIR   ++  G  S  SE    I  +D   +AP+ 
Sbjct: 20324 NHVNVPEC--AFTVTDLVEGGKYEFRIRA--KNTAGAISAPSESTETIICKDE-YEAPTI 20378

Query: 333   WYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDYEVTLTRWKSHLQNYTVNATKLTVNL 391
                +DP+   G     L  K       N   IL   +  + W        +  + +T  +
Sbjct: 20379 --VLDPTIKDG-----LTIKAGDTIVLNAISILGKPLPKSSWSK--AGKDIRPSDIT-QI 20428

Query: 392   TNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH------PVMDLKAFP--------KDN 437
             T+    + LT++    K DA   TI A +   T        V+D+   P           
Sbjct: 20429 TSTPTSSMLTIKYATRK-DAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAE 20487

Query: 438   MLWVEWTTPRES----VKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGN 485
                + WT P E     +K YILE        W V+S+         Q    V    ++GN
Sbjct: 20488 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDI-------QSCRHVATKLIQGN 20540

Query: 486   LAESKCYLITVTPVYADGPGSP---ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542
                   Y+  V+ V   G G P   E +K   +  PP          V KN A + W + 
Sbjct: 20541 E-----YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKR- 20594

Query: 543   PVDVQNGFIRNYTI 556
             PVD     I  Y +
Sbjct: 20595 PVDDGGSEITGYHV 20608



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 32/236 (13%)

Query: 150   RETHLETNFTLKSEWATH-----KFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEA---- 200
             RE H++   TL+           K    K  RD PT   +D + V    +E+   A    
Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS-KLEIRNAAHEDG 17284

Query: 201   -------ENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNP-SIKSV 252
                    EN  G  T   ++   +   KP PP +L V  SE       LTW  P      
Sbjct: 17285 GIYSLTVENPAGSKT---VSVKVLVLDKPGPPRDLEV--SEIRKDSCYLTWKEPLDDGGS 17339

Query: 253   IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312
             +I  Y ++ R   ++ WS   P    S + S   + L    +Y+FR+    + G+G + +
Sbjct: 17340 VITNYVVERRDVASAQWS---PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE 17396

Query: 313   WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
               +    +     P   P   + +D   T+    V LVW   P  +    I  Y V
Sbjct: 17397 TPKPIKALD-PLHPPGPPKDLHHVDVDKTE----VSLVWNK-PDRDGGSPITGYLV 17446



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 83/409 (20%), Positives = 149/409 (36%), Gaps = 58/409 (14%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTAST 280
             P PP  + + +S + S  + L W+ P       +  Y ++ R  +   W+ +  +    T
Sbjct: 27167 PGPPAKIRIADSTKSS--ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRT 27224

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
              + + V +LKP   Y FR+  +   G+G   + +E        + P        +     
Sbjct: 27225 -TEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIA 27283

Query: 341   TQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQN------YTVNATKLTVNLT- 392
               G     L+ +K  PP            T+T W+   +N      Y++  T  +  LT 
Sbjct: 27284 KAGEDVQVLIPFKGRPP-----------PTVT-WRKDEKNLGSDARYSIENTDSSSLLTI 27331

Query: 393   -----NDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP- 446
                  ND     LT+ N VG+  ++ +++   D  A    + +K   +  +  + W  P 
Sbjct: 27332 PQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLL-WDPPL 27390

Query: 447   ---RESVKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
                   +  Y++E        W V+S K    T ++  D           L+E   +   
Sbjct: 27391 IDGGSPIINYVIEKRDATKRTWSVVSHKCSS-TSFKLID-----------LSEKTPFFFR 27438

Query: 496   VTPVYADGPGSPESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
             V      G G P      +K A  P+    +  K   K   +L W +   D   G +   
Sbjct: 27439 VLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTK--PDFDGGSVITE 27496

Query: 555   TIFYRTIIGNETAVNVDSSHT-EYTLSSLTSDTLYMVRMAAYTDEGGKD 602
              +  R   G +T  +   S T E  +S L   ++   R+ A  ++G  D
Sbjct: 27497 YVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSD 27545



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 23/195 (11%)

Query: 125   PPEKPKNLSCIVNEGKK-MRCEW-----DGGRET---HLETNFTLKSEWATHKFADCKAK 175
             PPE P N   +++  K  +   W     DGG      ++E   T   +W  H        
Sbjct: 30328 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTT 30387

Query: 176   RDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV---KPNPPHNLSVIN 232
               T T    D         +  + A+N +G   +   +   V K    KP+ P  L +++
Sbjct: 30388 MYTVTGLVPD------AEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILS 30441

Query: 233   SEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
               + S  + L W  P       IL Y ++YR    S W +   E     +  FT+  L  
Sbjct: 30442 ISKDS--VTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQ--FTIGGLLE 30497

Query: 292   FTEYVFRIRCMKEDG 306
              TEY FR+    E G
Sbjct: 30498 ATEYEFRVFAENETG 30512



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 27/113 (23%), Positives = 50/113 (44%), Gaps = 5/113 (4%)

Query: 215   DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIP 273
             DP++   P PP    V   ++  S + L W  P+      +K Y ++ + +  + W ++ 
Sbjct: 15700 DPIFP--PGPPSCPEV--KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVN 15755

Query: 274   PEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRP 326
               D   T     V +LK   +Y FR++ + E G+   SD + E      ++ P
Sbjct: 15756 EPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEP 15808



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 105/493 (21%), Positives = 184/493 (37%), Gaps = 68/493 (13%)

Query: 147   DGGRETHLETNFTL-KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALG 205
             DGG E    TN+ + K E +   +A   A     TSC+V+   +     +  + AEN  G
Sbjct: 19415 DGGSEI---TNYIVDKRETSRPNWAQVSATVPI-TSCSVE-KLIEGHEYQFRICAENKYG 19469

Query: 206   KVTSDHINFDPVYKVKP-NPPHNLSV-INSEELSSILKLTWTNPSIKSVI-ILKYNIQYR 262
                 D +  +P     P +PP      + S      + ++W  P+      I  Y ++ R
Sbjct: 19470 --VGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR 19527

Query: 263   TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITY 322
                A  W+++  +         T   L+  TEY FR+  + + G G  SD + +A+    
Sbjct: 19528 ETQAVNWTKVNRKPIIERTLKAT--GLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARD 19584

Query: 323   EDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSH------ 376
                P   P+F    D + +    +V L W   P ++    I+ Y V + R  S       
Sbjct: 19585 PQYPPGPPAFPKVYDTTRS----SVSLSWGK-PAYDGGSPIIGYLVEVKRADSDNWVRCN 19639

Query: 377   -LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK 435
               QN      ++T  + + +Y   +   N +G SD +   +P             K +PK
Sbjct: 19640 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPS--DVPD------------KHYPK 19685

Query: 436   DNMLWVEWTTPRESVKKYILE-------WCVLSDKAPCITDWQQED------------GT 476
             D ++  E     +  K  IL        +  +  + P    W + +             T
Sbjct: 19686 DILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST 19745

Query: 477   VHRTYLR---GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKN 533
                T+LR    N  ++  Y++T+     +  G  E          P     V  K++ K+
Sbjct: 19746 DFDTFLRCENVNKYDAGKYILTL----ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKD 19801

Query: 534   EAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE-TAVNVDSSHTEYTLSSLTSDTLYMVRM 592
              A + W+   +D  +  I NY +  R       + V  + S T + +++L     Y  R+
Sbjct: 19802 SAYVTWEPPIIDGGSPII-NYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRV 19860

Query: 593   AAYTDEGGKDGPE 605
              A  + G  D  E
Sbjct: 19861 FAENEYGIGDPGE 19873



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 58/237 (24%), Positives = 95/237 (40%), Gaps = 30/237 (12%)

Query: 144   CEW-----DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW- 197
             C+W     DGG E     N+TL+ +  T   ++      T   C   YS    +  + + 
Sbjct: 14820 CKWEPPLDDGGSEI---INYTLEKKDKTKPDSEWIVVTSTLRHCK--YSVTKLIEGKEYL 14874

Query: 198   --VEAENALGK----VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS 251
               V AEN  G     V+   +  DP     P+ P    V +    S ++K  W  P    
Sbjct: 14875 FRVRAENRFGPGPPCVSKPLVAKDPFGP--PDAPDKPIVEDVTSNSMLVK--WNEPKDNG 14930

Query: 252   VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
               IL Y ++ R  +++ WS++      + +++  V  L     YVFR+      G G +S
Sbjct: 14931 SPILGYWLEKREVNSTHWSRVNKSLLNALKAN--VDGLLEGLTYVFRVCAENAAGPGKFS 14988

Query: 312   DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
               S+  +   ++      P      D S T    T++L W+  P F   G+I+ Y V
Sbjct: 14989 PPSDPKT--AHDPISPPGPPIPRVTDTSST----TIELEWEP-PAFNGGGEIVGYFV 15038



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 110/488 (22%), Positives = 175/488 (35%), Gaps = 72/488 (14%)

Query: 147   DGGRETHLETNFTL-KSEWATHKFADC-KAKRDTPTSCTVDYSTVYFVNIEVWVEAENAL 204
             DGG E    TN+ L K +   +K+  C  A + T    T  +  + +      V AEN  
Sbjct: 20103 DGGSEI---TNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYT---FRVSAENKY 20156

Query: 205   GKVTSDHINFDPVYKVKP------NPPHNLSVINSEELSSILKLTWTNPS-IKSVIILKY 257
             G    + +  +P+    P       PP N+  +  + +S    LTWT+P       I  Y
Sbjct: 20157 G--VGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVS----LTWTDPKKTGGSPITGY 20210

Query: 258   NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317
             +++++ +++  W +     T      F V  L    EY FR+  +   G G  S  SE  
Sbjct: 20211 HLEFKERNSLLWKRA--NKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV 20268

Query: 318   SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRW--KS 375
               +   D P K                 +V L+W T P ++   K+  Y V       KS
Sbjct: 20269 VALDPIDPPGKPEVI--------NITRNSVTLIW-TEPKYDGGHKLTGYIVEKRDLPSKS 20319

Query: 376   HLQNYTVNATKLTVNLTN----DRYLATLTVRNLVGKSDA---AVLTIPACDFQATHPVM 428
              ++   VN  +    +T+     +Y   +  +N  G   A   +  TI  C  +   P +
Sbjct: 20320 WMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETI-ICKDEYEAPTI 20378

Query: 429   DLKAFPKDNMLWVEWTT-------------PRESVKKYILEWCVLSDKAPCITDWQQEDG 475
              L    KD +      T             P+ S  K        + K    +D  Q   
Sbjct: 20379 VLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSK--------AGKDIRPSDITQITS 20430

Query: 476   TVHRTYLRGNLAESKC---YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGK 532
             T   + L    A  K    Y IT T  +       E +K  +   P   GP V    V  
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGT---KVEHVKVTVLDVPGPPGP-VEISNVSA 20486

Query: 533   NEAVLEWDQLPVDVQNGFIRNYTIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVR 591
              +A L W   P++     I++Y +  R T     T V+ D     +  + L     Y+ R
Sbjct: 20487 EKATLTWTP-PLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFR 20545

Query: 592   MAAYTDEG 599
             ++A    G
Sbjct: 20546 VSAVNHYG 20553



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 78/364 (21%), Positives = 137/364 (37%), Gaps = 31/364 (8%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYK----VKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
             E  V AEN +G +        PV+      KP+PP N   I++    + + LTW  P   
Sbjct: 17083 EFRVSAENEIG-IGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTT--CNSVDLTWQPPRHD 17139

Query: 251   SVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
                 IL Y ++Y+      W +      +   + + V  L+    Y FR+  +   G+  
Sbjct: 17140 GGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE-- 17197

Query: 310   WSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKIL 364
              SD +     +  +DR  + P      + +  Q  +      +  + K +P  +   K  
Sbjct: 17198 -SDPAHVPEPVLVKDR-LEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKE 17255

Query: 365   DYEVTLTRWKSHLQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ 422
             D +      K+ + + T   +KL +      D  + +LTV N  G    +V  +   D  
Sbjct: 17256 DRDAPT---KARI-DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVL-VLDKP 17310

Query: 423   ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGT-VHRTY 481
                  +++    KD+  ++ W  P +     I  + V+  +      W     T   +++
Sbjct: 17311 GPPRDLEVSEIRKDS-CYLTWKEPLDDGGSVITNY-VVERRDVASAQWSPLSATSKKKSH 17368

Query: 482   LRGNLAESKCYLITVTP--VYADGP--GSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537
                +L E   YL  V     Y  GP   +P+ IKA     PP     +    V K E  L
Sbjct: 17369 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 17428

Query: 538   EWDQ 541
              W++
Sbjct: 17429 VWNK 17432



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 67/273 (24%), Positives = 105/273 (38%), Gaps = 38/273 (13%)

Query: 356   PFEANGKILDYEVTLTRWKSHLQ------NYTVNATKLTVNLTNDRYLATLTVRNLVGKS 409
             P E  G  +DY +   R  SHL          + + K+T  L  + Y+  +T  N  G  
Sbjct: 25907 PQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVG 25966

Query: 410   DAAV-LTIPACD-FQATHPV--MDLKAFPKDNMLWVEWTTPRES----VKKYILE----- 456
             +    + I A D F    P   +++ +  K++M    W+ P       +  YI+E     
Sbjct: 25967 EPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLC-WSRPESDGGSEISGYIIERREKN 26025

Query: 457   ---WCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSP--ESI 510
                W V  +K P        D  V  T LR G   E + Y      +      SP   + 
Sbjct: 26026 SLRW-VRVNKKPVY------DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAE 26078

Query: 511   KAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV 570
                   +PPSK   V +   GK    + W + P+      I  YT+ Y+     +   ++
Sbjct: 26079 DPVFLPSPPSKPKIVDS---GKTTITIAWVK-PLFDGGAPITGYTVEYKKSDDTDWKTSI 26134

Query: 571   DSSH-TEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
              S   TEYT+S LT+   Y+ R+ +    G  D
Sbjct: 26135 QSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 26167



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 79/338 (23%), Positives = 118/338 (34%), Gaps = 36/338 (10%)

Query: 195   EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254
             E  +E +N  G  TS+ I    +   KP PP     I+  + +SI  ++W  P +     
Sbjct: 29808 EYTLELKNVTG-TTSETIKV--IILDKPGPPTGPIKIDEIDATSIT-ISWEPPELDGGAP 29863

Query: 255   LK-YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW--S 311
             L  Y ++ R      W    P   + TRS+F    L    EYVFR+      G G +  S
Sbjct: 29864 LSGYVVEQRDAHRPGWL---PVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQS 29920

Query: 312   DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDY---- 366
             +  E  S I     P     F    D         + L W   PP +  G ++  Y    
Sbjct: 29921 EVIECRSSIRIPGPPETLQIFDVSRD--------GMTLTW--YPPEDDGGSQVTGYIVER 29970

Query: 367   -EVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDF 421
              EV   RW    K  +      +T LT  L  +  +  +  R   GK       I A D 
Sbjct: 29971 KEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARG-SGKPSRPSKPIVAMDP 30029

Query: 422   QAT--HPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQ--EDGTV 477
              A    P            + + W+ P +     +  + +   K     +W +     T 
Sbjct: 30030 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKCNTTPTK 30088

Query: 478   HRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK 515
              R Y   +L +   Y   V    A GPG P  +   +K
Sbjct: 30089 IREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVK 30126



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 77/319 (24%), Positives = 122/319 (38%), Gaps = 54/319 (16%)

Query: 221   KPNPPHNLSVINSEELSSI-LKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTA 278
             +P PP  +  I  E +S+  + L+W  P       I  Y I+ R  +  TW  +  E   
Sbjct: 16216 RPGPP--VGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKE 16273

Query: 279   STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYE-----DRPSKAPSFW 333
              T   +T+  L    EYVFRI    + G G   D   E +   +      D+P+ +    
Sbjct: 16274 CT---YTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVS---- 16326

Query: 334   YKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWK----SHLQNYTVNA 384
                  S T+   TV   W+  P ++    +  Y     + T  RWK      ++  T+  
Sbjct: 16327 -----SVTRNSMTVN--WEE-PEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGV 16378

Query: 385   T-KLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDL-KAFPK-----DN 437
             + K+T  +    Y   +   N  G   A++ + PA    A  P+      FPK      +
Sbjct: 16379 SYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPA---TARDPIAPPGPPFPKVTDWTKS 16435

Query: 438   MLWVEWTTPRE----SVKKYILEWCVLSDKAPCITDWQQ-EDGTVHRTYL-RGNLAESKC 491
                +EW+ P +     V  YI+E+     K     +W++ +D  V  T L    L E   
Sbjct: 16436 SADLEWSPPLKDGGSKVTGYIVEY-----KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAF 16490

Query: 492   YLITVTPVYADGPGSPESI 510
             Y   V  V   G G P  +
Sbjct: 16491 YKFRVRAVNIAGIGEPGEV 16509



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 61/273 (22%), Positives = 93/273 (34%), Gaps = 24/273 (8%)

Query: 349   LVWKTLPPFEANG-KILDY-----EVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTV 402
             L W+  PP E  G +I +Y     E +   W        + +  +   +    Y   +  
Sbjct: 19407 LSWE--PPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICA 19464

Query: 403   RNLVGKSDAAVLTIPACDFQATHPVMD-----LKAFPKDNMLWVEWTTPRESVKKYILEW 457
              N  G  D  V T PA       P        +    KD+M  V W  P +     I  +
Sbjct: 19465 ENKYGVGDP-VFTEPAIAKNPYDPPGRCDPPVISNITKDHMT-VSWKPPADDGGSPITGY 19522

Query: 458   CVLSDKAPCITDWQQEDGT--VHRTYLRGNLAESKCYLITVTPVYADGPGSPE--SIKAY 513
              +L  +     +W + +    + RT     L E   Y   VT +   GPG P   S  AY
Sbjct: 19523 -LLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAY 19581

Query: 514   LK--QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVD 571
              +  Q PP      +     ++   L W +   D  +  I       R    N    N+ 
Sbjct: 19582 ARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLP 19641

Query: 572   SS--HTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
              +   T + ++ L  DT Y  R+ A    G  D
Sbjct: 19642 QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSD 19674



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 40/140 (28%), Positives = 56/140 (40%), Gaps = 17/140 (12%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKP--------NPPHNLSVINSEELSSILKLTWTNPSI 249
             V AEN  G ++    + +PV    P        NPP  L V  S      + L+W+ P  
Sbjct: 30302 VSAENQFG-ISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSS-----VSLSWSRPKD 30355

Query: 250   KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                  +  Y I+   K+ ST   +    T  T + +TV  L P  EY FRI    + G  
Sbjct: 30356 DGGSRVTGYYIE--RKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLS 30413

Query: 309   YWSDWSEEASGITYEDRPSK 328
               S  SE        D+PS+
Sbjct: 30414 ETSPASEPVVCKDPFDKPSQ 30433



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 84/373 (22%), Positives = 131/373 (35%), Gaps = 54/373 (14%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKP----NPPHNLSVINSEELSSILKLTWTNPSIKS-V 252
             V+AEN +G +    +   PV    P     PP N  V+++ + S  + L W  P      
Sbjct: 18470 VKAENEIG-IGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHS--ITLGWGKPVYDGGA 18526

Query: 253   IILKYNIQYRTK--DAST---WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
              I+ Y ++ R K  DAS    W +         R  FTV  L    EY FR+    + G 
Sbjct: 18527 PIIGYVVEMRPKIADASPDEGWKRCNAA-AQLVRKEFTVTSLDENQEYEFRVCAQNQVGI 18585

Query: 308   GYWSDWSEEASGITYEDRP---------------SKAPSFWYKIDPSHTQGYRTVQLVWK 352
             G  ++  E        + P               +  P   + I     +G    ++ W+
Sbjct: 18586 GRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAI----VRGRPAPKVTWR 18641

Query: 353   TLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAA 412
              +     +  +   +V L    + L     N+T+      +D    +LT+ N  G+  A 
Sbjct: 18642 KV---GIDNVVRKGQVDLVDTMAFL--VIPNSTR------DDSGKYSLTLVNPAGEK-AV 18689

Query: 413   VLTIPACDFQATHPVMDLKAFP-KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQ 471
              + +   D     PV DLK          V W  P       +  + V   +A   T W 
Sbjct: 18690 FVNVRVLD--TPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT-WS 18746

Query: 472   QEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP----TVR 526
                  V +T     NL     Y   VT V   GPG P  +   +  + P   P     + 
Sbjct: 18747 TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLE 18806

Query: 527   TKKVGKNEAVLEW 539
               ++ KN A L W
Sbjct: 18807 VTEMTKNSATLAW 18819



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 87/413 (21%), Positives = 149/413 (36%), Gaps = 50/413 (12%)

Query: 135   IVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNI 194
             +VN G+  R E D   +  L T   L+ +    + A C+ K     +  +    +     
Sbjct: 23636 VVNAGETFRLEADVHGKP-LPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694

Query: 195   EVWVEAENALGKVTSDHINFDPVYKV--KPNPPHN---LSVINSEELSSILKLTWTNP-S 248
             +  + A N  G  +     F    KV  +P PP     ++ + SE+ S    LTW+ P  
Sbjct: 23695 QYILRASNVAGSKS-----FPVNVKVLDRPGPPEGPVQVTGVTSEKCS----LTWSPPLQ 23745

Query: 249   IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                  I  Y ++ R      W+ +  E   +   S  V  L    EYVFRI  + + G G
Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTN---SLKVTKLLEGNEYVFRIMAVNKYGVG 23802

Query: 309   YWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
                      S       P   P     ++ ++     ++ + W   P  +   +I+ Y +
Sbjct: 23803 -----EPLESAPVLMKNPFVLPGPPKSLEVTNI-AKDSMTVCWNR-PDSDGGSEIIGY-I 23854

Query: 369   TLTRWKSHLQNYTVNATKLT------VNLTND-RYLATLTVRNL--VGKSDAAVLTIPAC 419
                R +S ++    N  ++T        LT D  Y   ++  N   VG+   A +   AC
Sbjct: 23855 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 23914

Query: 420   D--FQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKYILEWCVLSDKAPCITDWQ-- 471
             D  F+   P          N + + W  P       +  Y++E C   ++     +WQ  
Sbjct: 23915 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEE-----EWQIV 23969

Query: 472   -QEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP 523
               + G     +    L E + Y I V  +   G G   S+   +K     + P
Sbjct: 23970 TPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAP 24022



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 11/120 (9%)

Query: 195   EVWVEAENALG-----KVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
             E  V AEN  G     + +   +  D  Y   P PP N  V ++ + S+   L W  P  
Sbjct: 20643 EFRVSAENRAGIGPPSEASDSVLMKDAAYP--PGPPSNPHVTDTTKKSA--SLAWGKPHY 20698

Query: 250   KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
                + I  Y ++++      W +     TA   + F V DL+   +Y FRI  + + G G
Sbjct: 20699 DGGLEITGYVVEHQKVGDEAWIK-DTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 222   PNPPHNLSVINSEELSSILKLTWTNPSIK-SVIILKYNIQYRTKDASTWSQIPPEDTAST 280
             P+PP  L VIN  + ++ LK  WT P       I  Y ++ R      W  +   DT   
Sbjct: 14084 PSPPRWLEVINITKNTADLK--WTVPEKDGGSPITNYIVEKRDVRRKGWQTV---DTTVK 14138

Query: 281   RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYED 324
              +  TV  L   + YVFR+      G+   SD++E    +  +D
Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQ---SDYTEIEDSVLAKD 14179



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 8/113 (7%)

Query: 198   VEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILK 256
             +   N +G+ T+   + + V   KP+PP      +     SI  L+W  P       I  
Sbjct: 23302 ITVANVVGQKTA---SIEIVTLDKPDPPKGPVKFDDVSAESIT-LSWNPPLYTGGCQITN 23357

Query: 257   YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
             Y +Q R    + W  +        R++  V  LK  TEY FRI      G+ +
Sbjct: 23358 YIVQKRDTTTTVWDVV---SATVARTTLKVTKLKTGTEYQFRIFAENRYGQSF 23407



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 31/149 (20%), Positives = 57/149 (38%), Gaps = 13/149 (8%)

Query: 221   KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
             +P PP  + +   E     + ++W  P       I  Y ++ +   ++TW  +     A 
Sbjct: 25487 RPGPPGPIRI--DEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV---SQAV 25541

Query: 280   TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339
              R+S  +  L   +EY FR+      GK  +S+ S  A    Y   P   P       P 
Sbjct: 25542 ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESS--AVVAEYPFSPPGPPG-----TPK 25594

Query: 340   HTQGYRTVQLVWKTLPPFEANGKILDYEV 368
                  ++  LV   +P  +   +++ Y +
Sbjct: 25595 VVHATKSTMLVTWQVPVNDGGSRVIGYHL 25623


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,263,332
Number of Sequences: 37866
Number of extensions: 1769093
Number of successful extensions: 6217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 5218
Number of HSP's gapped (non-prelim): 854
length of query: 918
length of database: 18,247,518
effective HSP length: 111
effective length of query: 807
effective length of database: 14,044,392
effective search space: 11333824344
effective search space used: 11333824344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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