BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|28610147 interleukin 6 signal transducer isoform 1 precursor [Homo sapiens] (918 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 1888 0.0 gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 674 0.0 gi|115430248 gp130-like monocyte receptor [Homo sapiens] 255 1e-67 gi|4503081 colony stimulating factor 3 receptor isoform a precur... 249 1e-65 gi|27437045 colony stimulating factor 3 receptor isoform d precu... 245 1e-64 gi|24496783 colony stimulating factor 3 receptor isoform c precu... 241 2e-63 gi|27437042 colony stimulating factor 3 receptor isoform b precu... 215 2e-55 gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 187 4e-47 gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 187 4e-47 gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 167 3e-41 gi|4557040 oncostatin M receptor [Homo sapiens] 135 1e-31 gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 122 2e-27 gi|51093381 leptin receptor isoform 3 [Homo sapiens] 103 7e-22 gi|51093379 leptin receptor isoform 2 [Homo sapiens] 103 7e-22 gi|40254464 leptin receptor isoform 1 [Homo sapiens] 103 7e-22 gi|4759328 class I cytokine receptor [Homo sapiens] 87 9e-17 gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 80 9e-15 gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 80 9e-15 gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 80 9e-15 gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 76 1e-13 gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 76 1e-13 gi|222352127 sidekick 2 [Homo sapiens] 75 4e-13 gi|119220552 sidekick 1 [Homo sapiens] 74 6e-13 gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 74 8e-13 gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 74 8e-13 gi|4506107 prolactin receptor [Homo sapiens] 73 1e-12 gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 73 1e-12 gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 67 6e-11 gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 67 6e-11 gi|110349719 titin isoform N2-A [Homo sapiens] 62 3e-09 >gi|28610147 interleukin 6 signal transducer isoform 1 precursor [Homo sapiens] Length = 918 Score = 1888 bits (4891), Expect = 0.0 Identities = 918/918 (100%), Positives = 918/918 (100%) Query: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV Sbjct: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60 Query: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI Sbjct: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120 Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180 Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300 Query: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN Sbjct: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360 Query: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD Sbjct: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420 Query: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT Sbjct: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480 Query: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD Sbjct: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540 Query: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG Sbjct: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600 Query: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK Sbjct: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660 Query: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN Sbjct: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720 Query: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS Sbjct: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780 Query: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV Sbjct: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840 Query: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG Sbjct: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900 Query: 901 MPKSYLPQTVRQGGYMPQ 918 MPKSYLPQTVRQGGYMPQ Sbjct: 901 MPKSYLPQTVRQGGYMPQ 918 >gi|28610149 interleukin 6 signal transducer isoform 2 precursor [Homo sapiens] Length = 329 Score = 674 bits (1739), Expect = 0.0 Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV Sbjct: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60 Query: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI Sbjct: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120 Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180 Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300 Query: 301 CMKEDGKGYWSDWSEEASGITYED 324 CMKEDGKGYWSDWSEEASGITYED Sbjct: 301 CMKEDGKGYWSDWSEEASGITYED 324 >gi|115430248 gp130-like monocyte receptor [Homo sapiens] Length = 764 Score = 255 bits (652), Expect = 1e-67 Identities = 163/551 (29%), Positives = 268/551 (48%), Gaps = 14/551 (2%) Query: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKAKRDTP---TS 181 P KP+N+SC+ K + C W G+ET T +T+K +A K +C T S Sbjct: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112 Query: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239 C+ + N + VEAEN G + S H+ + + + K PP V + + Sbjct: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171 Query: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297 +++ W P + V LKY +++RT ++++W ++ ++ ++ + L+PFTEYV Sbjct: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231 Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPF 357 +RC ++ K +WSDWS+E G+T E+ P W + P+ G R V+L+WK Sbjct: 232 ALRCAVKESK-FWSDWSQEKMGMTEEEAPCGL-ELWRVLKPAEADGRRPVRLLWKKARGA 289 Query: 358 EANGKILDYEVTLTRWKSHLQNYTVNAT--KLTVNLTNDRYLATLTVRNLVGKSDAAVLT 415 K L Y + + T+N T +L ++L + + ++ N +GKS A L Sbjct: 290 PVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLR 349 Query: 416 IPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475 IPA ++ + ++A ++ L V+W + V +++EW D P W+ Sbjct: 350 IPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQ 409 Query: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEA 535 + T + L CY I+V P+ D G P SI+AY K+ PS+GP + + +G Sbjct: 410 ATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTV 469 Query: 536 VLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAY 595 + W ++P + G I NYTIFY+ G + V+SS +Y L SL T Y+V++ A Sbjct: 470 TITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMAS 529 Query: 596 TDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNV 655 T GG +G F T F+ EI I + L+ +L V + K + + WP V Sbjct: 530 TSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTV 589 Query: 656 PDPSKSHIAQW 666 P+P++S IA W Sbjct: 590 PNPAESSIATW 600 >gi|4503081 colony stimulating factor 3 receptor isoform a precursor [Homo sapiens] Length = 836 Score = 249 bits (635), Expect = 1e-65 Identities = 227/813 (27%), Positives = 357/813 (43%), Gaps = 76/813 (9%) Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64 TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++ Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60 Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122 I+W+ P ++Q S +T + L+C L +G Q + + + + Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119 Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174 G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179 Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234 K C + + N+ +WV+AENALG S + DP+ VK PP ++ S Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239 Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289 E + L+L W I K ++++ + ++W+ + P + + + + L Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297 Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346 P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351 Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400 VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408 Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458 N G S P ++ P + L A +D + LWV W P + Y++EW Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464 Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516 + A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++ Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576 PS P + K +GK A LEW P ++ + +YTIF+ + +++S Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584 Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636 + L L +LY + + A + G + T T E+ I+ L LLT L G Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644 Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694 L C R K +WP+VPDP+ S + W P F Q+ G + Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697 Query: 695 EIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTS 754 +E ++KKP P +S + + + T + + G S++P +S TS Sbjct: 698 VLEEDEKKPVP--WESHNSSETCGLPTLVQTYVLQGDPRAVSTQP--------QSQSGTS 747 Query: 755 STVQYSTVVHSGYRHQVPSVQVFSRSESTQPLL 787 V Y ++ S P + R +STQPLL Sbjct: 748 DQVLYGQLLGS---PTSPGPGHYLRCDSTQPLL 777 >gi|27437045 colony stimulating factor 3 receptor isoform d precursor [Homo sapiens] Length = 783 Score = 245 bits (626), Expect = 1e-64 Identities = 208/731 (28%), Positives = 325/731 (44%), Gaps = 63/731 (8%) Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64 TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++ Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60 Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122 I+W+ P ++Q S +T + L+C L +G Q + + + + Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119 Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174 G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179 Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234 K C + + N+ +WV+AENALG S + DP+ VK PP ++ S Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239 Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289 E + L+L W I K ++++ + ++W+ + P + + + + L Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297 Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346 P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351 Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400 VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408 Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458 N G S P ++ P + L A +D + LWV W P + Y++EW Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464 Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516 + A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++ Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576 PS P + K +GK A LEW P ++ + +YTIF+ + +++S Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584 Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636 + L L +LY + + A + G + T T E+ I+ L LLT L G Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644 Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694 L C R K +WP+VPDP+ S + W P F Q+ G + Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697 Query: 695 EIEANDKKPFP 705 +E ++KKP P Sbjct: 698 VLEEDEKKPVP 708 >gi|24496783 colony stimulating factor 3 receptor isoform c precursor [Homo sapiens] Length = 863 Score = 241 bits (615), Expect = 2e-63 Identities = 200/694 (28%), Positives = 312/694 (44%), Gaps = 59/694 (8%) Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64 TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++ Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60 Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122 I+W+ P ++Q S +T + L+C L +G Q + + + + Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119 Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174 G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179 Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234 K C + + N+ +WV+AENALG S + DP+ VK PP ++ S Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239 Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289 E + L+L W I K ++++ + ++W+ + P + + + + L Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297 Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346 P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351 Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400 VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408 Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458 N G S P ++ P + L A +D + LWV W P + Y++EW Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464 Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516 + A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++ Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576 PS P + K +GK A LEW P ++ + +YTIF+ + +++S Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584 Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636 + L L +LY + + A + G + T T E+ I+ L LLT L G Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644 Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSP 668 L C R K +WP+VPDP+ S + W P Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVP 675 >gi|27437042 colony stimulating factor 3 receptor isoform b precursor [Homo sapiens] Length = 769 Score = 215 bits (547), Expect = 2e-55 Identities = 179/634 (28%), Positives = 285/634 (44%), Gaps = 54/634 (8%) Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64 TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++ Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60 Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122 I+W+ P ++Q S +T + L+C L +G Q + + + + Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119 Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174 G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179 Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234 K C + + N+ +WV+AENALG S + DP+ VK PP ++ S Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239 Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289 E + L+L W I K ++++ + ++W+ + P + + + + L Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297 Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346 P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351 Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400 VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408 Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458 N G S P ++ P + L A +D + LWV W P + Y++EW Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464 Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516 + A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++ Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576 PS P + K +GK A LEW P ++ + +YTIF+ + +++S Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584 Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTT 610 + L L +LY + + A + G + T T Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMT 618 >gi|4504993 leukemia inhibitory factor receptor precursor [Homo sapiens] Length = 1097 Score = 187 bits (475), Expect = 4e-47 Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%) Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88 + P+ V+ + S+ T CV +EK + H N I + I ++ + ++ Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313 Query: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148 V FT E N++G I +G PP+ P+ L+C ++ K++ C W+ Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355 Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201 GR T L T++TL + + K+ K + + PT+ + N E++ + A Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413 Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261 N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+ Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470 Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319 + K S Q SS+ V L P+T Y FRIRC E WS WS + Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528 Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377 +T E PSK P W + + + + + WK LP EANGKIL Y V+ + L Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584 Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434 K + L + Y+ ++ +N VG S A + IP D + V K Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642 Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493 + + W Y+++WC S PC+ DW++ T + + Y Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698 Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553 + G S+ Y+++ P P + + +++W+ +PV+ GF+R Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758 Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 Y ++ R + + + V D S ++ L T Y + + AYTD G Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818 Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659 T + + G I AI++PV +A ++ + +L C+ KR+ IK+ +P++P+P Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877 Query: 660 KSHIAQW 666 Q+ Sbjct: 878 NCKALQF 884 >gi|189083786 leukemia inhibitory factor receptor precursor [Homo sapiens] Length = 1097 Score = 187 bits (475), Expect = 4e-47 Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%) Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88 + P+ V+ + S+ T CV +EK + H N I + I ++ + ++ Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313 Query: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148 V FT E N++G I +G PP+ P+ L+C ++ K++ C W+ Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355 Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201 GR T L T++TL + + K+ K + + PT+ + N E++ + A Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413 Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261 N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+ Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470 Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319 + K S Q SS+ V L P+T Y FRIRC E WS WS + Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528 Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377 +T E PSK P W + + + + + WK LP EANGKIL Y V+ + L Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584 Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434 K + L + Y+ ++ +N VG S A + IP D + V K Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642 Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493 + + W Y+++WC S PC+ DW++ T + + Y Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698 Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553 + G S+ Y+++ P P + + +++W+ +PV+ GF+R Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758 Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 Y ++ R + + + V D S ++ L T Y + + AYTD G Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818 Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659 T + + G I AI++PV +A ++ + +L C+ KR+ IK+ +P++P+P Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877 Query: 660 KSHIAQW 666 Q+ Sbjct: 878 NCKALQF 884 >gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] Length = 862 Score = 167 bits (424), Expect = 3e-41 Identities = 168/640 (26%), Positives = 264/640 (41%), Gaps = 63/640 (9%) Query: 72 FTIPKEQYTIINRTASSVTFTDIASLNIQLT----------CNILTFGQLEQNVYGITII 121 F + I+ + + F SLN Q+T C + E + G I Sbjct: 60 FHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIF 119 Query: 122 SGLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKR---- 176 G+ PE+P+NLSCI E + C W+ GR+THL T +TL+ + + K Sbjct: 120 VGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCD 179 Query: 177 --DTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234 D + T + N V A N+LG +S F + V+P PP ++ + + Sbjct: 180 YLDFGINLTPESPES---NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQK 236 Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294 S L W + + +L ++YR ++ W+ + + + + DLKPFTE Sbjct: 237 ASVSRCTLYWRDEGL----VLLNRLRYRPSNSRLWNMV---NVTKAKGRHDLLDLKPFTE 289 Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY---KIDPSHTQGYRTVQLVW 351 Y F+I KG WSDWSE T E+ P+ WY ID S Q + L W Sbjct: 290 YEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQ----ISLFW 345 Query: 352 KTLPPFEANGKILDYEVT---LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGK 408 K L EA GKIL Y+VT LT K+ QN T + + TV + ++ N G Sbjct: 346 KNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGS 405 Query: 409 S-DAAVLTIPACDFQATHP-VMDLKAFPKDNMLWVEWTTPRE---SVKKYILEWCVL--S 461 S + + C+ P + + DN+L V W PR+ +V++Y++EW L Sbjct: 406 SLPTRINIMNLCEAGLLAPRQVSANSEGMDNIL-VTWQPPRKDPSAVQEYVVEWRELHPG 464 Query: 462 DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSK 521 +W + + N+ CY I V + D G SI K P Sbjct: 465 GDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGD-QGGCSSILGNSKHKAPLS 523 Query: 522 GPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE----TAVNVDSSHTEY 577 GP + K ++ W+ +PV Q G + +Y I+++ N + S + Sbjct: 524 GPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSH 583 Query: 578 TLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTTPKFAQGEIE--AIVVP-VCLAFLLTT 633 ++SL Y++ M A T G G E F QG+ A V P +C+A ++ Sbjct: 584 PINSLQPRVTYVLWMTALTAAGESSHGNEREFC----LQGKANWMAFVAPSICIAIIMVG 639 Query: 634 LLGVLFCFNKRDLIKKHIWP-----NVPDPSKSHIAQWSP 668 + + K ++ + P +PDP+ S A+ P Sbjct: 640 IFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYP 679 >gi|4557040 oncostatin M receptor [Homo sapiens] Length = 979 Score = 135 bits (341), Expect = 1e-31 Identities = 140/587 (23%), Positives = 232/587 (39%), Gaps = 56/587 (9%) Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHL------ETNFTLKS 162 G + + + GI + E+PK+ SC + K + C WD G +T L ++TL Sbjct: 220 GNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFE 279 Query: 163 EWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222 ++ K C K T D Y + AEN L K S +I F+ ++V Sbjct: 280 SFSGEKKL-CTHKNWCNWQITQDSQETY----NFTLIAENYLRK-RSVNILFNLTHRVYL 333 Query: 223 NPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282 P +++ N ++I +TW SI++ I+ + + + Sbjct: 334 MNPFSVNFENVNATNAI--MTWKVHSIRNNFTYLCQIELHGEGKMMQYNV----SIKVNG 387 Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ 342 + + +L+P TEY+ R+RC WS+WS + + T E PS+AP W + S Sbjct: 388 EYFLSELEPATEYMARVRCADASHFWKWSEWSGQ-NFTTLEAAPSEAPDVWRIV--SLEP 444 Query: 343 GYRTVQLVWKTLPPFEANGKILDYEVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLA 398 G TV L WK L ANGKIL Y V + S L + A + L Y Sbjct: 445 GNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQI 504 Query: 399 TLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWC 458 + N VG S A+V+ I A V + + + + W V Y+++WC Sbjct: 505 CVIANNSVGASPASVIVISA--DPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWC 562 Query: 459 VLSDKAPCITDWQQEDGTVHRTYLR------GNLAESKCYLITVTPVYADGPGSPESIKA 512 + W+ T + G + + Y ++ + E Sbjct: 563 DHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIAC----LLEKKTG 618 Query: 513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGN-----ETA 567 Y ++ PS P V + + L W + Q GFI+ Y ++ ++ E A Sbjct: 619 YSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKA 678 Query: 568 VNVDSS-----------HTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQG 616 V D S + +L ++ Y + +T G +GP TFT Sbjct: 679 VLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAG--EGPSATFTKVT-TPD 735 Query: 617 EIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHI 663 E ++++ + L + LL ++ C+ K IK+ +P++PDP KS I Sbjct: 736 EHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSI 782 >gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] Length = 422 Score = 122 bits (306), Expect = 2e-27 Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%) Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90 ISP+ P + + S+ A C + D A + W N +P E ++N + ++ Sbjct: 43 ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99 Query: 91 FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150 ++ + N++ + + G + GLPPEKP N+SC K + C W G Sbjct: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159 Query: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206 ET L TN++LK + + + + T P SC + F E+WVEA N LG Sbjct: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219 Query: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264 SD + D + V +PP ++ V L L + W + P++K + KY I+YR + Sbjct: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279 Query: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319 D+ W + D S ++S + LKP T Y ++RC G WS+WS + Sbjct: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336 Query: 320 IT 321 T Sbjct: 337 ST 338 >gi|51093381 leptin receptor isoform 3 [Homo sapiens] Length = 958 Score = 103 bits (257), Expect = 7e-22 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%) Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91 P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393 Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143 ++ + + CN +Y I + + E L+ KM Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446 Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190 C W E+ L+ + S + + H + DC + D C + ++ Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504 Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 ++ +W+ ++LG + S P VKP PP ++ + + +LK++W P Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563 Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 L++ I+Y W D S S V DL Y ++RC + DG G Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620 Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367 YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680 Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426 + T N TK T T + T+ N +G S A + + Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740 Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483 V L A+P + + V W K +I+EW L++ W + +V + Y+ Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798 Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513 + + Y ++ P++ +G G P+ I ++ Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828 Score = 52.0 bits (123), Expect = 3e-06 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%) Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258 K+TS + F P+ VKP+PP L + +++ + LK++W++P + + + Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266 Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314 +QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323 >gi|51093379 leptin receptor isoform 2 [Homo sapiens] Length = 896 Score = 103 bits (257), Expect = 7e-22 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%) Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91 P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393 Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143 ++ + + CN +Y I + + E L+ KM Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446 Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190 C W E+ L+ + S + + H + DC + D C + ++ Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504 Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 ++ +W+ ++LG + S P VKP PP ++ + + +LK++W P Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563 Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 L++ I+Y W D S S V DL Y ++RC + DG G Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620 Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367 YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680 Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426 + T N TK T T + T+ N +G S A + + Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740 Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483 V L A+P + + V W K +I+EW L++ W + +V + Y+ Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798 Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513 + + Y ++ P++ +G G P+ I ++ Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828 Score = 52.0 bits (123), Expect = 3e-06 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%) Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258 K+TS + F P+ VKP+PP L + +++ + LK++W++P + + + Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266 Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314 +QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323 >gi|40254464 leptin receptor isoform 1 [Homo sapiens] Length = 1165 Score = 103 bits (257), Expect = 7e-22 Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%) Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91 P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393 Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143 ++ + + CN +Y I + + E L+ KM Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446 Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190 C W E+ L+ + S + + H + DC + D C + ++ Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504 Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 ++ +W+ ++LG + S P VKP PP ++ + + +LK++W P Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563 Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 L++ I+Y W D S S V DL Y ++RC + DG G Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620 Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367 YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680 Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426 + T N TK T T + T+ N +G S A + + Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740 Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483 V L A+P + + V W K +I+EW L++ W + +V + Y+ Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798 Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513 + + Y ++ P++ +G G P+ I ++ Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828 Score = 52.0 bits (123), Expect = 3e-06 Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%) Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258 K+TS + F P+ VKP+PP L + +++ + LK++W++P + + + Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266 Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314 +QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323 >gi|4759328 class I cytokine receptor [Homo sapiens] Length = 636 Score = 86.7 bits (213), Expect = 9e-17 Identities = 105/498 (21%), Positives = 180/498 (36%), Gaps = 34/498 (6%) Query: 219 KVKPNPPH-NLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277 ++KPN P V SE+ + W P+ S +L YR + W+ + PE Sbjct: 125 QMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELK 184 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 + +QDL+ T Y RC E + W +WS ++++ PS W + Sbjct: 185 TIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPI---LSFQTPPSAPKDVWVSGN 241 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397 T G L+WK A G + + W + T + + Sbjct: 242 LCGTPGGEEPLLLWK------APGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEW 295 Query: 398 ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEW 457 A ++ N L++ D + + + + L V W +++++W Sbjct: 296 ARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDW 355 Query: 458 CVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQA 517 D + +W + L GN Y ITVT V A G S S+ + ++ Sbjct: 356 ARDGDPLEKL-NWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREEL 414 Query: 518 PPSKGPTV-RTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576 P GPT+ R + + W ++P G + +YT+ ++ +NV + Sbjct: 415 APLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQS 474 Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636 TL L + A+ G GP P + V+P L LLG Sbjct: 475 VTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLP---DNTLRWKVLPGILFLWGLFLLG 531 Query: 637 VLF-------CFNKR-DLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNF 688 C++ R ++ + +W VPDP+ S Q PH +Q+ Sbjct: 532 CGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQ--PH---------MEQVPEAQPL 580 Query: 689 TDVSVVEIEANDKKPFPE 706 D+ ++E+E + P E Sbjct: 581 GDLPILEVEEMEPPPVME 598 >gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1 precursor [Homo sapiens] Length = 1912 Score = 80.1 bits (196), Expect = 9e-15 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%) Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277 K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I + Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 A+TR ++V L P+++Y FR+ + G+G SE T E PS AP Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391 S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482 Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445 + LA ++ + SD V+T Q ++ KA P+ + + + WT Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538 Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 PR +++ Y L V D + IT E GT +R L+G L + Y + Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589 Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558 G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649 Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605 + G + + + S T+Y L L T Y + + A+TD G GPE Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698 Score = 56.6 bits (135), Expect = 1e-07 Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281 P P N E S +L +WT P +S I Y + Y+ + +I T Sbjct: 516 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 567 Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341 +S+ +Q LKP + Y FR+ G G + E S T + +PS P PS T Sbjct: 568 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 624 Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394 ++ + W+ P + NG I +Y + T K H + + TK + Sbjct: 625 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 680 Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446 Y T+T VG +VL D + P + V W +P Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740 Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495 ++ Y + + +L D W+ +D T H + G E+ Y +T Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 799 Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555 VT G G+ K P + N A+++W PVD G ++ Y Sbjct: 800 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 857 Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 + F R + T + +T + + Y+ R++A G Sbjct: 858 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 902 Score = 43.9 bits (102), Expect = 7e-04 Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%) Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293 S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486 Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353 Y ++ G G S + IT P + +F K +P + ++ L W Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537 Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408 PP + I +YE+ + Q T+ + +L N Y L R+ G Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594 Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466 + A ++ + + P D+ P + V W P E I E+ + Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648 Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515 T ED H YL L + Y ITVT GPG PES+ ++ Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707 Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570 PP K V + V + W + Q+G IR Y + Y + E Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764 Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610 D++ + +S L +T Y + + AYT +G + P+ TT Sbjct: 765 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820 Score = 38.1 bits (87), Expect = 0.038 Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%) Query: 507 PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566 PE + Q S+G T L W + +NG I YT+ YR I N Sbjct: 914 PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 964 Query: 567 AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610 + ++ + T TL+ L DT Y V++ A+T +G G P F T Sbjct: 965 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013 Score = 30.8 bits (68), Expect = 6.1 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 237 SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291 S+ ++L+W P + ++ II KY + YR + I P DT + T+ LKP Sbjct: 932 STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 986 Query: 292 FTEYVFRIRCMKEDGKGYWS 311 T Y ++R G G +S Sbjct: 987 DTTYDVKVRAHTSKGPGPYS 1006 >gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2 precursor [Homo sapiens] Length = 1899 Score = 80.1 bits (196), Expect = 9e-15 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%) Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277 K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I + Sbjct: 307 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 360 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 A+TR ++V L P+++Y FR+ + G+G SE T E PS AP Sbjct: 361 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 415 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391 S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL Sbjct: 416 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 469 Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445 + LA ++ + SD V+T Q ++ KA P+ + + + WT Sbjct: 470 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 525 Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 PR +++ Y L V D + IT E GT +R L+G L + Y + Sbjct: 526 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 576 Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558 G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y Sbjct: 577 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636 Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605 + G + + + S T+Y L L T Y + + A+TD G GPE Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 685 Score = 56.6 bits (135), Expect = 1e-07 Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281 P P N E S +L +WT P +S I Y + Y+ + +I T Sbjct: 503 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 554 Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341 +S+ +Q LKP + Y FR+ G G + E S T + +PS P PS T Sbjct: 555 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 611 Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394 ++ + W+ P + NG I +Y + T K H + + TK + Sbjct: 612 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667 Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446 Y T+T VG +VL D + P + V W +P Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727 Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495 ++ Y + + +L D W+ +D T H + G E+ Y +T Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 786 Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555 VT G G+ K P + N A+++W PVD G ++ Y Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 844 Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 + F R + T + +T + + Y+ R++A G Sbjct: 845 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 889 Score = 43.9 bits (102), Expect = 7e-04 Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%) Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293 S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P Sbjct: 418 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 473 Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353 Y ++ G G S + IT P + +F K +P + ++ L W Sbjct: 474 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 524 Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408 PP + I +YE+ + Q T+ + +L N Y L R+ G Sbjct: 525 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 581 Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466 + A ++ + + P D+ P + V W P E I E+ + Sbjct: 582 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 635 Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515 T ED H YL L + Y ITVT GPG PES+ ++ Sbjct: 636 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 694 Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570 PP K V + V + W + Q+G IR Y + Y + E Sbjct: 695 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 751 Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610 D++ + +S L +T Y + + AYT +G + P+ TT Sbjct: 752 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807 Score = 38.1 bits (87), Expect = 0.038 Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%) Query: 507 PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566 PE + Q S+G T L W + +NG I YT+ YR I N Sbjct: 901 PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 951 Query: 567 AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610 + ++ + T TL+ L DT Y V++ A+T +G G P F T Sbjct: 952 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000 Score = 30.8 bits (68), Expect = 6.1 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 237 SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291 S+ ++L+W P + ++ II KY + YR + I P DT + T+ LKP Sbjct: 919 STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 973 Query: 292 FTEYVFRIRCMKEDGKGYWS 311 T Y ++R G G +S Sbjct: 974 DTTYDVKVRAHTSKGPGPYS 993 >gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3 precursor [Homo sapiens] Length = 1903 Score = 80.1 bits (196), Expect = 9e-15 Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%) Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277 K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I + Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 A+TR ++V L P+++Y FR+ + G+G SE T E PS AP Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391 S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482 Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445 + LA ++ + SD V+T Q ++ KA P+ + + + WT Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538 Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 PR +++ Y L V D + IT E GT +R L+G L + Y + Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589 Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558 G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649 Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605 + G + + + S T+Y L L T Y + + A+TD G GPE Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698 Score = 48.1 bits (113), Expect = 4e-05 Identities = 89/415 (21%), Positives = 166/415 (40%), Gaps = 43/415 (10%) Query: 221 KPN-PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDT 277 KP+ PP ++S S +SIL ++W P ++ II +Y+I+Y D Sbjct: 608 KPSAPPQDISC-TSPSSTSIL-VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI--TYEDRPSKAPSFWYK 335 S + + ++ L+ +TEY + + G G E S + T ED PS P K Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-----PESLSVLIRTNEDVPSGPPR---K 717 Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN--------YTVNATKL 387 ++ +V++ W++ P + +G+I Y+V R ++ +A + Sbjct: 718 VEVEAVNS-TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDM 776 Query: 388 TVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAF--PKDNMLWVEWTT 445 ++ +LTV K D A P + N ++W Sbjct: 777 IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP 836 Query: 446 PRES---VKKYILEWCVLSDKAPCIT-DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYA 501 P ++ ++ Y L++ D P T ++ +++ T ++ + Y+ ++ Sbjct: 837 PVDTFGPLQGYRLKFG-RKDMEPLTTLEFSEKEDHFTAT----DIHKGASYVFRLSARNK 891 Query: 502 DGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560 G G + + + P+ P + ++ L W + +NG I YT+ YR Sbjct: 892 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951 Query: 561 IIGNETAVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610 I N + ++ + T TL+ L DT Y V++ A+T +G G P F T Sbjct: 952 I--NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004 Score = 43.9 bits (102), Expect = 7e-04 Identities = 90/407 (22%), Positives = 147/407 (36%), Gaps = 59/407 (14%) Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293 S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486 Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353 Y ++ G G S + IT P + +F K +P + ++ L W Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537 Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408 PP + I +YE+ + Q T+ + +L N Y L R+ G Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594 Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466 + A ++ + + P D+ P + V W P E I E+ + Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648 Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515 T ED H YL L + Y ITVT GPG PES+ ++ Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707 Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-- 569 PP K V + V + W + Q+G IR Y + Y + E Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764 Query: 570 ----VDSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610 + + + +S L +T Y + + AYT +G + P+ TT Sbjct: 765 LKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 811 >gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1 precursor [Homo sapiens] Length = 1907 Score = 76.3 bits (186), Expect = 1e-13 Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%) Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278 K P PP +L V +E ++ + LTW + + + V Y IQYR A T D Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369 Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338 +T + +++ L PF+EY FR+ + G+G SE T E PS P + Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421 Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388 + T+ + W+ PP E NG + Y V T W H + + T L Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479 Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442 +T R LA V + V T +PA DFQA ++++ + + W+ Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533 Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500 P+E + Y L + D+ QQ T T Y +L Y + Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586 Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558 G G +I+A Q+ PS P V +G + W P D +NG I Y++ Y Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646 Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605 + G + +V H+ + L L T Y V + A+TD G GPE Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695 Score = 75.5 bits (184), Expect = 2e-13 Identities = 87/407 (21%), Positives = 167/407 (41%), Gaps = 51/407 (12%) Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281 PP + ++ S+ ++++W P S +I +Y++ Y D + + + Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666 Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338 SS+ + L+ +TEY +R + G G E+S + T ED PS P +++P Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719 Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR---------------------WK-SH 376 ++ V + WK P + +G+I Y+VT R W+ Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE 776 Query: 377 LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKD 436 ++Y + LT T +A T + +S ++T P M + + Sbjct: 777 SEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMN 834 Query: 437 NMLWVEWTTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYL 493 L ++W P+E + Y L++C + P D+ ++D + + L + Y+ Sbjct: 835 TAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYI 889 Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552 + G G + + PS P + + + L WD + +NG I Sbjct: 890 FRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949 Query: 553 NYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 +YT+ +R I + N+ ++ T +TL+ L DT Y +++ A+T +G Sbjct: 950 SYTVVFRDINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 995 Score = 52.0 bits (123), Expect = 3e-06 Identities = 83/411 (20%), Positives = 149/411 (36%), Gaps = 54/411 (13%) Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294 E + ++L+W P + +I+ + + + +D ++ + T SS+T++DLKP T Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577 Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354 Y F++ + G G ++ E T + PS P + + G TV++ W Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630 Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400 P NG I Y V + H V K T Y + Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684 Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453 VG +++ + + + + P ++ P ++ + V W P S ++ Y Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744 Query: 454 ILEWCVLSDKAP-----------CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD 502 + + L + P W+ E+ + T + G L Y +TV Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISG-LTPETTYSVTVAAYTTK 803 Query: 503 GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTI 561 G G+ K PT+ N A+L+W P G + Y + Y R Sbjct: 804 GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRAD 861 Query: 562 IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612 ++ +T++ L T Y+ R+AA G + E TP+ Sbjct: 862 EARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 912 Score = 41.2 bits (95), Expect = 0.004 Identities = 97/412 (23%), Positives = 152/412 (36%), Gaps = 59/412 (14%) Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296 +S + + W P + ++ Y + Y T D+ + TV L P Y Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485 Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356 R+ G G S + T + P++ F +++ S T+ +QL W LPP Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536 Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413 E +I+ YE+ + Q + V + D TL L +SD V Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593 Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462 TI A Q+T K + V W P +S I ++ V D Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653 Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516 + + D + H ++ L + Y + V GPG PES ++ Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFY-RTIIGNETAVNV---- 570 PP K V + + + W +LPV Q+G IR Y + Y R G + + Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765 Query: 571 ----------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610 +S E T+S LT +T Y V +AAYT +G + P+ TT Sbjct: 766 MLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 817 Score = 30.4 bits (67), Expect = 7.9 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%) Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282 P NL V +S +L W P + ++ I+ Y + +R D ++ ++ +T + Sbjct: 919 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 971 Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308 FT+ LKP T Y ++R G G Sbjct: 972 RFTLTGLKPDTTYDIKVRAWTSKGSG 997 >gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2 precursor [Homo sapiens] Length = 1898 Score = 76.3 bits (186), Expect = 1e-13 Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%) Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278 K P PP +L V +E ++ + LTW + + + V Y IQYR A T D Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369 Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338 +T + +++ L PF+EY FR+ + G+G SE T E PS P + Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421 Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388 + T+ + W+ PP E NG + Y V T W H + + T L Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479 Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442 +T R LA V + V T +PA DFQA ++++ + + W+ Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533 Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500 P+E + Y L + D+ QQ T T Y +L Y + Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586 Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558 G G +I+A Q+ PS P V +G + W P D +NG I Y++ Y Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646 Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605 + G + +V H+ + L L T Y V + A+TD G GPE Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695 Score = 74.7 bits (182), Expect = 4e-13 Identities = 87/400 (21%), Positives = 167/400 (41%), Gaps = 46/400 (11%) Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281 PP + ++ S+ ++++W P S +I +Y++ Y D + + + Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666 Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338 SS+ + L+ +TEY +R + G G E+S + T ED PS P +++P Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719 Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS---------------HLQNYTVN 383 ++ V + WK P + +G+I Y+VT R ++ Q T++ Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTIS 776 Query: 384 ATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443 LT T +A T + +S ++T P M + + L ++W Sbjct: 777 G--LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMNTAL-LQW 831 Query: 444 TTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 P+E + Y L++C + P D+ ++D + + L + Y+ + Sbjct: 832 HPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYIFRLAAKN 887 Query: 501 ADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559 G G + + PS P + + + L WD + +NG I +YT+ +R Sbjct: 888 RAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947 Query: 560 TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 I + N+ ++ T +TL+ L DT Y +++ A+T +G Sbjct: 948 DINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 986 Score = 46.2 bits (108), Expect = 1e-04 Identities = 83/404 (20%), Positives = 147/404 (36%), Gaps = 49/404 (12%) Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294 E + ++L+W P + +I+ + + + +D ++ + T SS+T++DLKP T Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577 Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354 Y F++ + G G ++ E T + PS P + + G TV++ W Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630 Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400 P NG I Y V + H V K T Y + Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684 Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453 VG +++ + + + + P ++ P ++ + V W P S ++ Y Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744 Query: 454 ILEWCVLSDKAP----CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPES 509 + + L + P I D + T + G L Y +TV G G+ Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEA--QETTISG-LTPETTYSVTVAAYTTKGDGARSK 801 Query: 510 IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568 K PT+ N A+L+W P G + Y + Y R + Sbjct: 802 PKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRADEARPNTI 859 Query: 569 NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612 + +T++ L T Y+ R+AA G + E TP+ Sbjct: 860 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903 Score = 42.0 bits (97), Expect = 0.003 Identities = 96/403 (23%), Positives = 151/403 (37%), Gaps = 50/403 (12%) Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296 +S + + W P + ++ Y + Y T D+ + TV L P Y Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485 Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356 R+ G G S + T + P++ F +++ S T+ +QL W LPP Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536 Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413 E +I+ YE+ + Q + V + D TL L +SD V Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593 Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462 TI A Q+T K + V W P +S I ++ V D Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653 Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516 + + D + H ++ L + Y + V GPG PES ++ Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709 Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFYRTIIGNETA---VNVD- 571 PP K V + + + W +LPV Q+G IR Y + Y + E + D Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765 Query: 572 --SSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610 + E T+S LT +T Y V +AAYT +G + P+ TT Sbjct: 766 MLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808 Score = 30.4 bits (67), Expect = 7.9 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%) Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282 P NL V +S +L W P + ++ I+ Y + +R D ++ ++ +T + Sbjct: 910 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 962 Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308 FT+ LKP T Y ++R G G Sbjct: 963 RFTLTGLKPDTTYDIKVRAWTSKGSG 988 >gi|222352127 sidekick 2 [Homo sapiens] Length = 2172 Score = 74.7 bits (182), Expect = 4e-13 Identities = 134/595 (22%), Positives = 219/595 (36%), Gaps = 92/595 (15%) Query: 104 NILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWD-------GGRETHLET 156 N + G Q V G T S +P P N+S + M W G + Sbjct: 1179 NAIGSGPWSQTVVGRTRES-VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237 Query: 157 NFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINF-D 215 + K +F + T +V EV V A +G + H + Sbjct: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLT---GLGKYVLYEVQVLAFTRIGDGSPSHPPILE 1294 Query: 216 PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275 P PP + ++ E ++ ++L W P+ + IIL Y I +R + +T + E Sbjct: 1295 RTLDDVPGPP--MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL-NTTTANTATVE 1351 Query: 276 DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335 A + +T LKP + Y+FRI G W + + EA +T E R P Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRITAQTRKG---WGE-AAEALVVTTEKRDRPQPPSRPM 1407 Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWKSHLQNYTVNATKLTVN 390 + + R+V L W+ P + + Y E+ RW H + + NA+ V+ Sbjct: 1408 VQQEDVRA-RSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVD 1464 Query: 391 LTND--RYLATLTVRNLVGKSD-----AAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443 Y + N +G S+ ++ T+ A +A ++ + ++L + W Sbjct: 1465 RLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP-TILSVTPHTTTSVL-IRW 1522 Query: 444 TTPRESVKKYIL----------------------------EWCVLSD-------KAPCIT 468 P E IL W L+ P +T Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582 Query: 469 DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRT 527 ++ ++ HR Y ++V +GP SP + ++ +A P+ P V Sbjct: 1583 QYELDNLNKHRRYE---------IRMSVYNAVGEGPSSPPQ-EVFVGEAVPTAAPRNVVV 1632 Query: 528 KKVGKNEAVLEWDQLPVDVQNGFIRNYTI-FYRTIIGN--ETAVNVDSSHTEYTLSSLTS 584 + + W+ P+D QNG I+ Y I F+ GN E + + L +LT Sbjct: 1633 HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692 Query: 585 DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAF--LLTTLLGV 637 T YMV +AA+ G DGP +TP Q + A P + F L TT + V Sbjct: 1693 YTAYMVSVAAFNAAG--DGPR---STPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742 Score = 45.1 bits (105), Expect = 3e-04 Identities = 118/529 (22%), Positives = 193/529 (36%), Gaps = 58/529 (10%) Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHK 168 GQ ++ +++ P P+N+ + + +W E+H N LK + Sbjct: 674 GQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESH--QNGILKGYIIRYC 731 Query: 169 FADC------KAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK-VTSDHINFDPVYKVK 221 A K D + + + + N E+ V A N+ G V S + + V Sbjct: 732 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791 Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNI---QYRTKDASTWSQIPPED 276 PP N+ + S+ ++ TW PS + + I Y + + ++ T P Sbjct: 792 TVPPGNVHAEATN--STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNF 849 Query: 277 TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAP--SFWY 334 S F V LK FTEY + C G G S T+ED P SF Sbjct: 850 QDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDG---PRSTPQLVRTHEDVPGPVGHLSFSE 905 Query: 335 KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV-------TLTRWKSHLQNYTV--NAT 385 +D S +++ W+ P E NG + Y + T TR +L N T+ T Sbjct: 906 ILDTS-------LKVSWQ--EPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT 956 Query: 386 KLTVNLTNDRYLATLTVRNLVGKSDAAVLTI-----PACDFQATHPVMDLKAFPKDNMLW 440 LT T +A +T + G+ + TI P T+ + + + Sbjct: 957 GLTALTTYTIEVAAMTSK---GQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF 1013 Query: 441 VEWTTPRESVKKYILE--WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTP 498 + S+ ++++E V+ + + Q + R+ +L CY + Sbjct: 1014 RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQ 1073 Query: 499 VYADG--PGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRN-- 553 V G P S S K QAPP P V + + L W LP NG + Sbjct: 1074 VNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133 Query: 554 YTIFYRTIIGNETAVN---VDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 Y I Y G+ ++ D +YT+ L T Y V++ A+ G Sbjct: 1134 YKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182 Score = 45.1 bits (105), Expect = 3e-04 Identities = 99/465 (21%), Positives = 168/465 (36%), Gaps = 72/465 (15%) Query: 196 VWVEAENALGKVT-SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254 V V+A NA+G S + V + P N+S + + S +++ + + ++ ++ Sbjct: 1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLV 1232 Query: 255 LKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314 L Y + Y+ KD+ T + + S+RS+ + L + Y ++ G G S Sbjct: 1233 LGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEVQVLAFTRIGDG--SPSH 1289 Query: 315 EEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK 374 T +D P P T +V+L+W+ PP NG IL Y++T Sbjct: 1290 PPILERTLDDVP--GPPMGILFPEVRT---TSVRLIWQ--PPAAPNGIILAYQIT----- 1337 Query: 375 SHLQNYTVNATKLTVNLTNDR------------YLATLTVRNLVGKSDAAVLTIPACDFQ 422 L T N + V + R YL +T + G +AA + + + Sbjct: 1338 HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR 1397 Query: 423 -----ATHPVMDLKAFPKDNML--WVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475 + P++ + ++L W + V+ Y ++ L W Sbjct: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR-----WALHSA 1452 Query: 476 TVHR---TYLRGNLAESKCYLITV--TPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKV 530 +V +++ L Y V T D S ES QA P + PT+ + Sbjct: 1453 SVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTP 1512 Query: 531 GKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI------------IGNETAVNVD------ 571 +VL W D NG + + I YR + I N A + Sbjct: 1513 HTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYS 1572 Query: 572 ------SSHTEYTLSSLTSDTLYMVRMAAY--TDEGGKDGPEFTF 608 S T+Y L +L Y +RM+ Y EG P+ F Sbjct: 1573 MRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVF 1617 Score = 43.9 bits (102), Expect = 7e-04 Identities = 99/435 (22%), Positives = 162/435 (37%), Gaps = 63/435 (14%) Query: 225 PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDA--STWSQIPPE 275 P N+S+ + E S L L W N + +SV Y I+Y D T S + + Sbjct: 1100 PANVSLRTASETS--LWLRWMPLPEMEYNGNPESV---GYKIKYSRSDGHGKTLSHVVQD 1154 Query: 276 DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335 +T++DL+ +TEY +++ G G WS+ G T E PS P+ Sbjct: 1155 ---RVERDYTIEDLEEWTEYRVQVQAFNAIGSG---PWSQTVVGRTRESVPSSGPTNVSA 1208 Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDR 395 + + + ++ + W +P + NG +L Y+V S Q + + N Sbjct: 1209 LATTSS----SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQ------PRFWLVEGNSS 1258 Query: 396 YLATLTVRNLVGKSDAAVLTIPAC-DFQATHP-----VMDLKAFPKDNMLWVEWTT---- 445 A LT + VL D +HP +D P +L+ E T Sbjct: 1259 RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVR 1318 Query: 446 ----PRESVKKYILEWCVLS--DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPV 499 P + IL + + + T + R Y L YL +T Sbjct: 1319 LIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ 1378 Query: 500 YADGPGSPESIKAYL-------KQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552 G G E+ +A + + PPS+ P V+ + V +L W+ P +R Sbjct: 1379 TRKGWG--EAAEALVVTTEKRDRPQPPSR-PMVQQEDVRARSVLLSWE--PGSDGLSPVR 1433 Query: 553 NYTIFYRTIIGNETAV---NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE--FT 607 YTI R + A+ +V + + + + L T Y R+ A D G + E + Sbjct: 1434 YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESES 1493 Query: 608 FTTPKFAQGEIEAIV 622 TT + A E I+ Sbjct: 1494 LTTLQAAPDEAPTIL 1508 Score = 43.5 bits (101), Expect = 0.001 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 9/143 (6%) Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283 P H ++ +++ E +I LTWT P + +++Y ++ +A + D +T S Sbjct: 593 PEHPVATLSTVERRAI-NLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT--S 649 Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQG 343 TV+ L P Y FR+ + + GKG +S++ ++ + P AP I T Sbjct: 650 VTVKGLVPARSYQFRLCAVNDVGKG---QFSKDTERVSLPEEPPTAPP-QNVIASGRTN- 704 Query: 344 YRTVQLVWKTLPPFEANGKILDY 366 +++ + W+ P NG + Y Sbjct: 705 -QSIMIQWQPPPESHQNGILKGY 726 Score = 40.8 bits (94), Expect = 0.006 Identities = 46/199 (23%), Positives = 77/199 (38%), Gaps = 11/199 (5%) Query: 409 SDAAVLTIPACDFQATHPVMDLKAFPKD--NMLWVEWTTPRESVKKYILEWCVLSDKAPC 466 S +A L + HPV L + N+ W + + +YILE + + AP Sbjct: 579 SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE--MSENNAPW 636 Query: 467 ITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPG--SPESIKAYLKQAPPSKGPT 524 D ++G L ++ Y + V G G S ++ + L + PP+ P Sbjct: 637 TVLLASVDPKATSVTVKG-LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695 Query: 525 VRTKKVGKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI---IGNETAVNVDSSHTEYTLS 580 N++++ +W P QNG ++ Y I Y +G + D+ L Sbjct: 696 NVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755 Query: 581 SLTSDTLYMVRMAAYTDEG 599 L T Y + +AAY G Sbjct: 756 DLIIWTNYEIEVAAYNSAG 774 Score = 32.3 bits (72), Expect = 2.1 Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 10/91 (10%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS----QIPPEDT 277 P PP ++ SS + + W++ I +Y I+ R D W IP E + Sbjct: 1825 PGPPGVPIIVR---YSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 + T F++ LKP Y FR+ + + G G Sbjct: 1882 SYT---FSMDILKPGVSYDFRVIAVNDYGFG 1909 >gi|119220552 sidekick 1 [Homo sapiens] Length = 2213 Score = 73.9 bits (180), Expect = 6e-13 Identities = 123/493 (24%), Positives = 199/493 (40%), Gaps = 64/493 (12%) Query: 191 FVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 FV E+ V A +G V S + + P PP L V L+S+ ++ W P Sbjct: 1346 FVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSV-RIVWQPPEE 1403 Query: 250 KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309 + IIL Y I YR +S + E A+ R FT DL P + Y+FR+ G Sbjct: 1404 PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ-FTATDLAPESAYIFRLSAKTRQG--- 1459 Query: 310 WSDWSE--EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY- 366 W E EA+ IT E R AP + + R+++L W +P + I + Sbjct: 1460 ---WGEPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQW--VPGSDGASPIRYFT 1513 Query: 367 ----EVTLTRWKSHLQNYTVNATKLTVNLTND--RYLATLTVRNLVGKSDAAVLTIPACD 420 E+ W+++ + + AT V+ Y L N +G SD + T Sbjct: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573 Query: 421 FQAT--HPVMDLKAFPKD-NMLWVEWTTPRES-----VKKYILEWCVLSDKAPCITDW-- 470 Q P + A P + + ++W PR+ ++ Y + + L +A T+ Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633 Query: 471 -------------QQEDGTVHR--TYLRGNLAESKCY-----LITVTPVYADGPGSPESI 510 Q TV+ T L K Y ++T + + P S + Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAP-V 1692 Query: 511 KAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568 + ++ +A P+ P V+ + ++ + WD P + QNG I+ Y I+Y NET Sbjct: 1693 EVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK 1752 Query: 569 N--VDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVC 626 + L +LTS T Y+V ++A+ G DGP+ + P+ + A P Sbjct: 1753 MKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAG--DGPK---SDPQQGRTHQAAPGAPSF 1807 Query: 627 LAF--LLTTLLGV 637 LAF + +T L V Sbjct: 1808 LAFSEITSTTLNV 1820 Score = 58.9 bits (141), Expect = 2e-08 Identities = 86/402 (21%), Positives = 156/402 (38%), Gaps = 41/402 (10%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTW----SQIPPEDT 277 P+ P NL V + S + L+W P + IL Y ++ +++ S W S + PE T Sbjct: 668 PHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVEL-SENNSPWKVHLSNVGPEMT 726 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 TV L P Y FR+ + E G+G +S E S + + P AP K Sbjct: 727 G-----VTVSGLTPARTYQFRVCAVNEVGRG---QYSAETSRLMLPEEPPSAPP---KNI 775 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDY--EVTLTRWKSHLQNYTVNATKLTVNLTNDR 395 + + +++ + W+ P E NG + Y L Q + + ++ L D Sbjct: 776 VASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDL 835 Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNM---------LWVEWTTP 446 + T + + A + + T + + P N+ + W P Sbjct: 836 IIWTQYEIQVAAYNGAGLGVFSRAVTEYT--LQGVPTAPPQNVQTEAVNSTTIQFLWNPP 893 Query: 447 RESVKKYI------LEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 + I L W + +A + + VH ++ NL + Y +V Sbjct: 894 PQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT-NLKKFTAYFTSVLCFT 952 Query: 501 ADGPGSPESIK-AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559 G G P + + + ++ P + ++ + W Q P++ +NG I Y I + Sbjct: 953 TPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSW-QEPLE-KNGIITGYQISWE 1010 Query: 560 TIIGNETAV--NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 N++ + ++S+ EY + L+S T Y + +AA T G Sbjct: 1011 VYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG 1052 Score = 52.8 bits (125), Expect = 1e-06 Identities = 122/527 (23%), Positives = 197/527 (37%), Gaps = 87/527 (16%) Query: 125 PPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK--RDTPTSC 182 P PKN+ + + +W ET E N L+ ++ A + + TS Sbjct: 768 PSAPPKNIVASGRTNQSIMVQWQPPPET--EHNGVLRGYILRYRLAGLPGEYQQRNITSP 825 Query: 183 TVDYSTV----YFVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELS 237 V+Y V + E+ V A N G V S + + V PP N + +E ++ Sbjct: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQN---VQTEAVN 882 Query: 238 SI-LKLTWTNPSIKSV--IILKYNIQYRTKDAS---TWSQIPPEDTASTRSSFTVQDLKP 291 S ++ W P + + I Y + DA T I P+ T +LK Sbjct: 883 STTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT--NLKK 940 Query: 292 FTEYVFRIRCMKEDGKGYWSD----WSEEASGITYEDRPSKAP--SFWYKIDPSHTQGYR 345 FT Y + C G G S W T ED+P SF +D S Sbjct: 941 FTAYFTSVLCFTTPGDGPPSTPQLVW-------TQEDKPGAVGHLSFTEILDTS------ 987 Query: 346 TVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN-----YTVNATKLTVNLTNDRYLATL 400 +++ W+ P E NG I Y+++ W+ + +N +T+N+T + L T Sbjct: 988 -LKVSWQE--PLEKNGIITGYQIS---WEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041 Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVM-----DLKAFPKDNMLWVEWTTPRE------- 448 T+ D A +T + + DL P + L + +PR Sbjct: 1042 TI-------DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN--LVISNISPRSATLQFRP 1092 Query: 449 ------SVKKYILEWCV--LSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500 S+ ++I+E V + D+ +T +++E+ + NL Y + V Sbjct: 1093 GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVN 1152 Query: 501 ADGPG--SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRN--YT 555 GP SP S QAPP PT V + + L W LP NG + Y Sbjct: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYR 1212 Query: 556 I-FYRTIIGNETAVNV--DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 I ++R+ + + V D E+T+ L Y ++M A+ G Sbjct: 1213 IKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVG 1259 Score = 52.0 bits (123), Expect = 3e-06 Identities = 94/405 (23%), Positives = 154/405 (38%), Gaps = 45/405 (11%) Query: 225 PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277 P +++V + E S L+L W N + +SV Y I+Y D + S + + Sbjct: 1177 PTSVTVRTASETS--LRLRWVPLPDSQYNGNPESV---GYRIKYWRSDLQS-SAVAQVVS 1230 Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337 FT+++L+ + EY +++ G G WSE G T E PS AP Sbjct: 1231 DRLEREFTIEELEEWMEYELQMQAFNAVGAG---PWSEVVRGRTRESVPSAAPENVSAEA 1287 Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL------TRWKSHL--QNYTVNATKLTV 389 S TQ + L W ++P + NG IL Y++ +SH+ N+T +A + Sbjct: 1288 VSSTQ----ILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343 Query: 390 NLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE--WTTPR 447 L L + + L + A P + L FP+ + V W P Sbjct: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSVRIVWQPPE 1402 Query: 448 ES---VKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGP 504 E + Y + + + S T E G R + +LA Y+ ++ G Sbjct: 1403 EPNGIILGYQIAYRLASSSPHTFT--TVEVGATVRQFTATDLAPESAYIFRLSAKTRQGW 1460 Query: 505 GSP---ESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560 G P I ++ P P + V +V L+W +P IR +T+ R Sbjct: 1461 GEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW--VPGSDGASPIRYFTMQVRE 1518 Query: 561 IIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602 + E + ++ T + L T Y +R+ A D G D Sbjct: 1519 LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSD 1563 Score = 47.0 bits (110), Expect = 8e-05 Identities = 93/424 (21%), Positives = 158/424 (37%), Gaps = 64/424 (15%) Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTAST 280 +P PP L V +E + L+L W S + I + +Q R W Q + Sbjct: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEW-QTYSSSISHE 1534 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI-TYEDRPSKAPSFWYKIDPS 339 ++ V L+PFT Y R++ + G SD+S E + T +D P + P P Sbjct: 1535 ATACVVDRLRPFTSYKLRLKATNDIGD---SDFSSETEAVTTLQDVPGEPPGS-VSATPH 1590 Query: 340 HTQGYRTVQLVWKTLPPFEANGKI---------LDYEVTLTRWKSHLQN-------YTVN 383 T +V + W+ NG + L+YE L+N T Sbjct: 1591 TTS---SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647 Query: 384 ATKLTVNLTND-------------RYLATLTVRNLVGKSDA-AVLTIPACDFQATHPVMD 429 ++ TVN ++ RY +T N++G+S A A + + + + Sbjct: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707 Query: 430 LKAFP-KDNMLWVEW-TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYL----- 482 ++ P + L V W P ES I + + +A D Q E + +L Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEA----DSQNETEKMKVLFLPEPVV 1763 Query: 483 -RGNLAESKCYLITVTPVYA--DGPGS-PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLE 538 NL YL++++ A DGP S P+ + + QA P + ++ + Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH--QAAPGAPSFLAFSEITSTTLNVS 1821 Query: 539 WDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEY-TLSSLTSDTLYMVRM 592 W + NG ++ Y + Y + + V V + + + LT Y R+ Sbjct: 1822 WGE--PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRV 1879 Query: 593 AAYT 596 A T Sbjct: 1880 QART 1883 Score = 30.4 bits (67), Expect = 7.9 Identities = 60/287 (20%), Positives = 109/287 (37%), Gaps = 53/287 (18%) Query: 161 KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK--VTSDHINFDPVY 218 + EW T+ + T+C VD F + ++ ++A N +G +S+ + Sbjct: 1521 RGEWQTYS----SSISHEATACVVDRLRP-FTSYKLRLKATNDIGDSDFSSETEAVTTLQ 1575 Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRT------------- 263 V PP ++S + +S + + W P +S+ ++ Y I YR Sbjct: 1576 DVPGEPPGSVSA--TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633 Query: 264 --------KDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSE 315 + + S +++ST + + LK + Y + G+ S S Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGE---SPASA 1690 Query: 316 EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS 375 E P+ AP + +Q +++ W PP NG I Y++ W++ Sbjct: 1691 PVEVFVGEAAPAMAPQNVQVTPLTASQ----LEVTWDPPPPESQNGNIQGYKIYY--WEA 1744 Query: 376 HLQNYTVNATKLTV--------NLT-NDRYLATLTVRNLVG---KSD 410 QN T L + NLT + +YL +++ N G KSD Sbjct: 1745 DSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791 >gi|24430212 interleukin 23 receptor precursor [Homo sapiens] Length = 629 Score = 73.6 bits (179), Expect = 8e-13 Identities = 61/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 78 QYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQN-VYGITIISGLPPEKPKNLSCIV 136 Q T IN+T + + + + + + C ++ + G I SG PP+ P ++C++ Sbjct: 76 QITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVI 135 Query: 137 NE-GKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIE 195 E M C W+ G+ T+++T + + K + + ++ TS ++ ST + Sbjct: 136 YEYSGNMTCTWNAGKLTYIDTKYVVHV-----KSLETEEEQQYLTSSYINISTDSLQGGK 190 Query: 196 ---VWVEAENALGKVTSD--HINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIK 250 VWV+A NALG S I+ D + IN+ +I + W + + Sbjct: 191 KYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTI--IYWDSQT-- 246 Query: 251 SVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW 310 ++ + ++Y+ TW+ + DT T + L+P +YVF++RC +E GK YW Sbjct: 247 TIEKVSCEMRYKATTNQTWN-VKEFDTNFTYVQQSEFYLEPNIKYVFQVRC-QETGKRYW 304 Query: 311 SDWS 314 WS Sbjct: 305 QPWS 308 >gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo sapiens] Length = 1183 Score = 73.6 bits (179), Expect = 8e-13 Identities = 131/577 (22%), Positives = 219/577 (37%), Gaps = 72/577 (12%) Query: 204 LGKVTSDHINFDPVYKVK--PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261 + T D ++ V V PNPP +L + +++L ++L+WT + I K+ I+Y Sbjct: 611 VANTTLDSVSASAVLSVVDVPNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY 668 Query: 262 RTKDASTWSQIPPEDTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI 320 +DA + T + + T Q L P+ Y FR+ + GK S+ SE+ + Sbjct: 669 --EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--L 724 Query: 321 TYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WK 374 T P K P+ ++ ++ V + WK L FE+NG L Y+V+ + W Sbjct: 725 TKASEPDKNPT---AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWT 780 Query: 375 S----HLQNYTVNATKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVM 428 S ++ Y V+ T V YL + N +G A V+ D P Sbjct: 781 SVVVANVSKYIVSGTPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGN 835 Query: 429 DLKAFPKDNMLWVEW-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYL 482 + V W P +S++ + I W S +++ T + Sbjct: 836 VRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKT 895 Query: 483 RG---NLAESKCYLITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537 G L Y + V V +GP SP+ + + PS +++ + L Sbjct: 896 HGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTL 954 Query: 538 EWDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRM 592 EWD P NG + YT+ Y+ I +G + + ++ T +TL +L T Y Sbjct: 955 EWD--PPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYF 1012 Query: 593 AAYTDEG-GKDGPEFTFTTPKFAQGEIEAIV------VPVCLAFLLTTLLGVLFCFNKRD 645 A T G G E TT A + + + + A L L+ ++ CF +R+ Sbjct: 1013 YAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRN 1072 Query: 646 LIKK---------HIWPNV-----PDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDV 691 K H P + D + + H P + + +D Sbjct: 1073 KGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDD 1132 Query: 692 SVVEIEANDKKPFPEDLKSLDLF--KKEKINTEGHSS 726 S+V+ F ED + + KKEK EG+ S Sbjct: 1133 SLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNES 1169 >gi|4506107 prolactin receptor [Homo sapiens] Length = 622 Score = 73.2 bits (178), Expect = 1e-12 Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 21/203 (10%) Query: 124 LPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTL----KSEWATHKFADCKAKRDTP 179 LPP KP+ C + C W G + L TN++L + E H+ D P Sbjct: 26 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYIT--GGP 83 Query: 180 TSCTV--DYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLS--VINSEE 235 SC Y++++ I + V A N +G SD + D Y V+P+PP L+ V E+ Sbjct: 84 NSCHFGKQYTSMWRTYI-MMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPED 142 Query: 236 LSSILKLTWTNPSIKSV----IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291 L + W+ P++ + L Y I+ + + A+ W A ++ F + L P Sbjct: 143 RKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE----IHFAGQQTEFKILSLHP 198 Query: 292 FTEYVFRIRCMKEDGKGYWSDWS 314 +Y+ ++RC + GYWS WS Sbjct: 199 GQKYLVQVRCKPD--HGYWSAWS 219 >gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo sapiens] Length = 1304 Score = 73.2 bits (178), Expect = 1e-12 Identities = 108/444 (24%), Positives = 177/444 (39%), Gaps = 57/444 (12%) Query: 216 PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275 PVY V PNPP +L + +++L ++L+WT + I K+ I+Y +DA + Sbjct: 642 PVYDV-PNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY--EDAMHKPGLWHH 696 Query: 276 DTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY 334 T + + T Q L P+ Y FR+ + GK S+ SE+ +T P K P+ Sbjct: 697 QTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--LTKASEPDKNPT--- 751 Query: 335 KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WKS----HLQNYTVNA 384 ++ ++ V + WK L FE+NG L Y+V+ + W S ++ Y V+ Sbjct: 752 AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSG 810 Query: 385 TKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE 442 T V YL + N +G A V+ D P + V Sbjct: 811 TPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVH 865 Query: 443 W-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYLRG---NLAESKCYL 493 W P +S++ + I W S +++ T + G L Y Sbjct: 866 WDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYT 925 Query: 494 ITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFI 551 + V V +GP SP+ + + PS +++ + LEWD P NG + Sbjct: 926 LNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPSHPNGIL 982 Query: 552 RNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPE 605 YT+ Y+ I +G + + ++ T +TL +L T Y A T G G E Sbjct: 983 TEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042 Query: 606 FTFTT--------PKFAQGEIEAI 621 TT P G+++A+ Sbjct: 1043 EAVTTVDEAGILPPDVGAGKVQAV 1066 Score = 45.1 bits (105), Expect = 3e-04 Identities = 151/791 (19%), Positives = 277/791 (35%), Gaps = 128/791 (16%) Query: 23 ELLDPCGYIS-PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTI 81 E+ DP + PE VVQ S + C +K H + ++W ++ +P ++ Sbjct: 541 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD-----HTLSLTVLWLKDNRELPSDERFT 595 Query: 82 INR--------------TASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPE 127 +++ T + V T + S++ +++ VY + P Sbjct: 596 VDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDV-------PN 648 Query: 128 KPKNLSCIVNEGKKMRCEWDGGRETHLE-TNFTLKSEWATHKFADCKAKRDTP-TSCTVD 185 P +L K ++ W G + + T F ++ E A HK + + T T Sbjct: 649 PPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQ 708 Query: 186 YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWT 245 +VN V A N++GK + + K + +V L +TW Sbjct: 709 LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK 768 Query: 246 --NPSIKSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCM 302 N + L+Y + +R KD W+ + + S + V F Y+ +++ + Sbjct: 769 PLNGFESNGPGLQYKVSWRQKDGDDEWTSV----VVANVSKYIVSGTPTFVPYLIKVQAL 824 Query: 303 KEDGKGYWSDWSEEASGITYEDRPSKAPS--------------FW----YKIDPSHTQGY 344 + G ++ G + ED P AP W K H QGY Sbjct: 825 NDMG---FAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGY 881 Query: 345 RTVQLVWKTLPPFEANGKILDYEV-TLTRWKSH--------LQNYTVNATKLTVNLTNDR 395 R WKT + N + ++ ++ T K+H +YT+N V + N + Sbjct: 882 RIYY--WKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLN-----VRVVNGK 934 Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRES---VKK 452 + + V + V + P+ + +P +D L +EW P + + Sbjct: 935 GEGPASP-DRVFNTPEGVPSAPS-SLKIVNPTLD--------SLTLEWDPPSHPNGILTE 984 Query: 453 YILEWCVLS---DKAPCI--------TDWQQED---GTVHRTYLRGNLAESKCYLIT--- 495 Y L++ ++ + P + T W ++ T ++ Y + IT Sbjct: 985 YTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEA 1044 Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555 VT V G P+ ++ P T + A + W+ + N ++ Sbjct: 1045 VTTVDEAGILPPDVGAGKVQAVNPRISNL--TAAAAETYANISWEYEGPEHVNFYVEYGV 1102 Query: 556 IFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQ 615 + E V+ S + + L L T Y VR+ A D G + T P A Sbjct: 1103 AGSKEEWRKEI---VNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMAS 1159 Query: 616 GEIEAIV----VPVCLAFLLTTLLGVLFCFNKRDLIKK---------HIWPNV-----PD 657 +++ + + A L L+ ++ CF +R+ K H P + D Sbjct: 1160 RQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDD 1219 Query: 658 PSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLF--K 715 + + H P + + +D S+V+ F ED + + K Sbjct: 1220 GTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGK 1279 Query: 716 KEKINTEGHSS 726 KEK EG+ S Sbjct: 1280 KEKEPAEGNES 1290 >gi|22212918 ciliary neurotrophic factor receptor preproprotein [Homo sapiens] Length = 372 Score = 67.4 bits (163), Expect = 6e-11 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%) Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181 GLPP +P LSC N K C W T++ F + + K C+ Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163 Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 C + Y ++ + +V + NALG + I FD VKP+PP N+ L Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222 Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297 ++TW PS LK+ ++YR W + D ++ T+ D EY+ Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278 Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326 ++ K++ G WSDWS A + + P Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306 >gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo sapiens] Length = 372 Score = 67.4 bits (163), Expect = 6e-11 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%) Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181 GLPP +P LSC N K C W T++ F + + K C+ Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163 Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240 C + Y ++ + +V + NALG + I FD VKP+PP N+ L Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222 Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297 ++TW PS LK+ ++YR W + D ++ T+ D EY+ Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278 Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326 ++ K++ G WSDWS A + + P Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 61.6 bits (148), Expect = 3e-09 Identities = 133/570 (23%), Positives = 211/570 (37%), Gaps = 63/570 (11%) Query: 70 NHFTIPKEQYTIINRTASSVTFTDIASLNIQLTC----NILTFGQLEQNVYGI--TIISG 123 +H+ I K + + ++ T S T++ +LN ++T N F + N YGI + SG Sbjct: 24835 SHYIIEKRETSRLSWTQVS---TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESG 24891 Query: 124 --------LPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFA 170 PP P M W DGG T +E K + ++ Sbjct: 24892 PVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGG--TEIEGYILEKRDKEGVRWT 24949 Query: 171 DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENA--LGKVTSDHINF---DPVYKVKPNPP 225 C K T V T + E V AENA +G+ + + + D +Y P PP Sbjct: 24950 KCNKKTLTDLRLRVTGLTEGH-SYEFRVAAENAAGVGEPSEPSVFYRACDALYP--PGPP 25006 Query: 226 HNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTASTRSSF 284 N V ++ S + L W+ P +K Y ++ + A W+ P T F Sbjct: 25007 SNPKVTDTSRSS--VSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP-TGLQGKQF 25063 Query: 285 TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEAS--GITYEDRPSKAPSFWYKIDPSHTQ 342 TV LK TEY FRI + +G G E A+ G + P D Sbjct: 25064 TVTKLKENTEYNFRICAINSEGVG------EPATLPGSVVAQERIEPPEIELDADLRKVV 25117 Query: 343 GYR---TVQL--VWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397 R T++L K P E + + +T ++T+ + RY Sbjct: 25118 VLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRY- 25176 Query: 398 ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKY 453 LT+ N G S A + + D + + ++ KD++ + W P + Y Sbjct: 25177 -NLTLENNSG-SKTAFVNVRVLDSPSAPVNLTIREVKKDSVT-LSWEPPLIDGGAKITNY 25233 Query: 454 ILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSP-ESIKA 512 I+E + KA + T+ NL E Y V G G P E+ + Sbjct: 25234 IVEKRETTRKAYATI----TNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEP 25289 Query: 513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDS 572 PP V V +N A ++W++ P I Y + +T + + Sbjct: 25290 VKVSEPPLPPGRVTLVDVTRNTATIKWEK-PESDGGSKITGYVVEMQTKGSEKWSTCTQV 25348 Query: 573 SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602 E T+S LT+ Y+ R+AA ++G D Sbjct: 25349 KTLEATISGLTAGEEYVFRVAAVNEKGRSD 25378 Score = 59.3 bits (142), Expect = 2e-08 Identities = 115/452 (25%), Positives = 173/452 (38%), Gaps = 58/452 (12%) Query: 195 EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELS-SILKLTWTNPSIKSVI 253 E V AENA G + I+ + NPP +V+ + S + + L W+ P + Sbjct: 28224 EFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGM 28283 Query: 254 -ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312 I+ Y I+ D W ++ E TR +TV DL+ EY FR+ + GKG D Sbjct: 28284 EIIGYIIEMCKADLGDWHKVNAEACVKTR--YTVTDLQAGEEYKFRVSAINGAGKG---D 28338 Query: 313 WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKILDYE 367 E I DR + AP + T R + + ++ P A D Sbjct: 28339 SCEVTGTIKAVDRLT-APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSN 28397 Query: 368 VTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPV 427 ++L R H + T N ND TLTV N G S + T+ D Sbjct: 28398 LSL-RADIHTTDSFSTLTVENCN-RNDAGKYTLTVENNSG-SKSITFTVKVLDTPGPPGP 28454 Query: 428 MDLKAFPKDNMLWVEWTTP----RESVKKYILE--------WCVLSDKAPCITDWQQEDG 475 + K + + + W P + Y++E W V+S+K Sbjct: 28455 ITFKDVTRGSAT-LMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKC----------- 28502 Query: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGS----PESIKAYLKQAPPSKGPTVRTKKVG 531 + + +LAE Y V+ V G G PE I A + APP + V T Sbjct: 28503 -TRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---S 28558 Query: 532 KNEAVLEWDQLPVDVQNGF-IRNYTIFYRTIIGNETAVNVDSSHTE---YTLSSLTSDTL 587 K+ AVL W L D G I Y + R + V++ HT+ +T+ L T Sbjct: 28559 KSSAVLAW--LKPDHDGGSRITGYLLEMRQ---KGSDFWVEAGHTKQLTFTVERLVEKTE 28613 Query: 588 YMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE 619 Y R+ A D G + P F++ + +IE Sbjct: 28614 YEFRVKAKNDAGYSE-PREAFSSVIIKEPQIE 28644 Score = 55.5 bits (132), Expect = 2e-07 Identities = 100/407 (24%), Positives = 147/407 (36%), Gaps = 49/407 (12%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280 P PP +L V S+ +L+W P +K Y I+ RT D W+++ P+ ++T Sbjct: 15912 PGPPKDLKV--SDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTT 15969 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340 F V DL +Y FR+R G G E T D P P K+ Sbjct: 15970 ---FVVPDLLSEQQYFFRVRAENRFGIG---PPVETIQRTTARD-PIYPPDPPIKLKIGL 16022 Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK---------SHLQNYTVNATKLTVN- 390 TV L WK P + + Y V W V + TV Sbjct: 16023 IT-KNTVHLSWKP-PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 16080 Query: 391 -LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH--PVMDLKAFPK-DNMLWVEWTTP 446 + Y + N G S + T+ CD Q P +DLK F + + V Sbjct: 16081 LVEGGEYEFRVKAVNAAGVSKPSA-TVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAK 16139 Query: 447 RESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------ 494 + V L W K P ++ ++ T++ + + C L+ Sbjct: 16140 IKGVPFPTLTWFKAPPKKP-----DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194 Query: 495 TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554 T+T V G S E L + P GP ++ + V ++ L W P D I NY Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGP-IKFESVSADQMTLSWFP-PKDDGGSKITNY 16252 Query: 555 TIFYRTIIGNETAVNVDSSHTE--YTLSSLTSDTLYMVRMAAYTDEG 599 I R +T V+V S E YT+ L Y+ R+ A G Sbjct: 16253 VIEKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYG 16298 Score = 54.7 bits (130), Expect = 4e-07 Identities = 139/610 (22%), Positives = 219/610 (35%), Gaps = 94/610 (15%) Query: 77 EQYTIINRTASSVTFTDIASLNIQLTC---------NILTFGQLEQNVYGI--------- 118 + Y + R S + +T++AS +Q+T N F + N YG+ Sbjct: 21588 DHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPV 21646 Query: 119 -TIISGLPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTL-KSEWATHKFAD 171 + PP+ PKN M W DGG E N+ + + + A ++ Sbjct: 21647 LAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI---INYIVERRDKAGQRWIK 21703 Query: 172 CKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV-----KPNPPH 226 C K T V T E + AENA G S P YK KP PP Sbjct: 21704 CNKKTLTDLRYKVSGLTEGH-EYEFRIMAENAAG--ISAPSPTSPFYKACDTVFKPGPPG 21760 Query: 227 NLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQI-PPEDTASTRSSF 284 N V+++ S + + W P I Y ++ + W + PP +T S+ Sbjct: 21761 NPRVLDTSRSS--ISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT--SY 21816 Query: 285 TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGY 344 T+ L EY RI M +G G G + P D Sbjct: 21817 TITGLTENQEYKIRIYAMNSEGLGE----PALVPGTPKAEDRMLPPEIELDADLRKVVTI 21872 Query: 345 RT-------VQLVWKTLPPFE---ANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTN- 393 R V + + P + +G+ LD K+ +++ T + T L V N Sbjct: 21873 RACCTLRLFVPIKGRPAPEVKWARDHGESLD--------KASIES-TSSYTLLIVGNVNR 21923 Query: 394 -DRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RE 448 D LTV N G S +A + + D + +K K ++ + W P Sbjct: 21924 FDSGKYILTVENSSG-SKSAFVNVRVLDTPGPPQDLKVKEVTKTSVT-LTWDPPLLDGGS 21981 Query: 449 SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKC-YLITVTPVYADGPGSP 507 +K YI+E + KA + H+T + + + C Y V G G P Sbjct: 21982 KIKNYIVEKRESTRKA-----YSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLP 22036 Query: 508 ----ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIG 563 ES+KA + PP K + V +N L W++ P I Y + +T Sbjct: 22037 AETAESVKASERPLPPGK---ITLMDVTRNSVSLSWEK-PEHDGGSRILGYIVEMQTKGS 22092 Query: 564 NETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVV 623 ++ A TE T++ L Y R++A ++G D + + P A+ +V+ Sbjct: 22093 DKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ--LSVPVIAKD----LVI 22146 Query: 624 PVCLAFLLTT 633 P L T Sbjct: 22147 PPAFKLLFNT 22156 Score = 54.7 bits (130), Expect = 4e-07 Identities = 102/436 (23%), Positives = 167/436 (38%), Gaps = 54/436 (12%) Query: 195 EVWVEAENALG----KVTSDHINF-DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 E V AENA G TS I DPV+ P+PP +++S + + + + W P Sbjct: 26054 EYRVYAENAAGLSLPSETSPLIRAEDPVFL--PSPPSKPKIVDSGKTT--ITIAWVKPLF 26109 Query: 250 KS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSS-FTVQDLKPFTEYVFRIRCMKEDGK 307 I Y ++Y+ D + W S R + +T+ L EYVFR++ + + G Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKT----SIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 26165 Query: 308 GYWSDWSEEASGITYEDRP------SKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG 361 SD S+ E+ P + K S T TV + +P Sbjct: 26166 SDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTM---TVPFRGRPVP-----N 26217 Query: 362 KILDYEVTLTRWKSHLQNYTVNATKLTVNLT--NDRYLATLTVRNLVGKSDAAVLTIPAC 419 + T R ++++ T + T LT+ ND TLT++N++ + + L + Sbjct: 26218 VLWSKPDTDLRTRAYVDT-TDSRTSLTIENANRNDSGKYTLTIQNVLSAA-SLTLVVKVL 26275 Query: 420 DFQATHPVMDLKAFPKDNMLWVEWTTPRES----VKKYILEWCVLSDKAPCITDWQQEDG 475 D + ++ K++ + + W P VK Y +E S KA W Sbjct: 26276 DTPGPPTNITVQDVTKESAV-LSWDVPENDGGAPVKNYHIEKREASKKA-----WVSVTN 26329 Query: 476 TVHR-TYLRGNLAESKCYLITVTPVYADGPGSP----ESIKAYLKQAPPSKGPTVRTKKV 530 +R +Y NL E Y V+ G G P E +K K +PP K + + Sbjct: 26330 NCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEK---LGVTSI 26386 Query: 531 GKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-VDSSHTEYTLSSLTSDTLYM 589 K+ L W L + G + + G + V + T + +S L ++ Y Sbjct: 26387 SKDSVSLTW--LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYF 26444 Query: 590 VRMAAYTDEGGKDGPE 605 R+ A G D E Sbjct: 26445 FRVFAENQAGLSDPRE 26460 Score = 54.3 bits (129), Expect = 5e-07 Identities = 73/261 (27%), Positives = 103/261 (39%), Gaps = 40/261 (15%) Query: 198 VEAENALGKVTSDHINFDPVYKVK-----PNPPHNLSVINSEELSSILKLTWTNPSIKS- 251 V A N +G T + + D + + P PP N+++ + + LTW P Sbjct: 13164 VSARNRVG--TGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFG--VSLTWEPPEYDGG 13219 Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRS----SFTVQDLKPFTEYVFRIRCMKEDGK 307 I Y I+ R K + W DTA T S TV D+ EY FR+R G Sbjct: 13220 AEITNYVIELRDKTSIRW------DTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGV 13273 Query: 308 GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGK-ILDY 366 G S + +RPS + S Q +VQL W+ PP + G IL Y Sbjct: 13274 GKPSAATPFVKVADPIERPSPPVNL-----TSSDQTQSSVQLKWE--PPLKDGGSPILGY 13326 Query: 367 EVTLTRWKSHLQNYTVNATKLTVNLT--------NDRYLATLTVRNLVGKSDAAVLTIP- 417 + R + N+ KL LT ++YL ++ N G SD + + P Sbjct: 13327 --IIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPL 13384 Query: 418 ACDFQATHPVMDLKAFPKDNM 438 D P MDL AF KD + Sbjct: 13385 TADDAFVEPTMDLSAF-KDGL 13404 Score = 53.1 bits (126), Expect = 1e-06 Identities = 98/420 (23%), Positives = 159/420 (37%), Gaps = 36/420 (8%) Query: 198 VEAENALGKVT-SDHINF----DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS- 251 V A NA G S+ NF +P Y P PP V+++ + S + L WT P Sbjct: 29315 VTAVNAAGNSEPSEASNFISCREPSYT--PGPPSAPRVVDTTKHS--ISLAWTKPMYDGG 29370 Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311 I+ Y ++ + KD W ++ T + FTV DLK +Y FR+ + G S Sbjct: 29371 TDIVGYVLEMQEKDTDQWYRVHTNATIRN-TEFTVPDLKMGQKYSFRVAAVNVKG---MS 29426 Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT 371 ++SE + I +R + P D T R + + ++ + Sbjct: 29427 EYSESIAEIEPVER-IEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGI 29485 Query: 372 RWKSHLQNYTVNATKLTVNLTNDRYLA---TLTVRNLVGKSDAAVLTIPACDFQATHPVM 428 S T + L + +RY A T+ N GK A VL + D P + Sbjct: 29486 DLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVL-VKVYDTPGPCPSV 29544 Query: 429 DLKAFPKDNMLWVEWTTPR----ESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR- 483 +K +D++ + W P V YI+E + + ++ +T R Sbjct: 29545 KVKEVSRDSVT-ITWEIPTIDGGAPVNNYIVE-----KREAAMRAFKTVTTKCSKTLYRI 29598 Query: 484 GNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542 L E Y V P G G P E+ A L P + V K+ L W++ Sbjct: 29599 SGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK- 29657 Query: 543 PVDVQNGFIRNYTIFYRTIIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599 P+ + Y + G E V + + E+T++SL Y+ R+ A ++G Sbjct: 29658 PLYDGGSRLTGY-VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 29716 Score = 51.6 bits (122), Expect = 3e-06 Identities = 99/421 (23%), Positives = 165/421 (39%), Gaps = 46/421 (10%) Query: 201 ENALGKVTSDHINFDPVYKV--KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKY 257 EN+ GK + V KV P PP N++V + S+ + TW P I I+ Y Sbjct: 19769 ENSCGKK-----EYTIVVKVLDTPGPPVNVTVKEISKDSAYV--TWEPPIIDGGSPIINY 19821 Query: 258 NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317 +Q R + +WS + E +++SF V +L+ Y FR+ E G G D E Sbjct: 19822 VVQKRDAERKSWSTVTTE---CSKTSFRVANLEEGKSYFFRVFAENEYGIG---DPGETR 19875 Query: 318 SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL----TRW 373 + P P K+ + + + WK P + +I+ Y V +W Sbjct: 19876 DAVKASQTP--GPVVDLKV---RSVSKSSCSIGWKK-PHSDGGSRIIGYVVDFLTEENKW 19929 Query: 374 KSHLQNYTV--NATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLK 431 + +++ ++ +A LT Y ++ N G+ + +T+ A D P +DLK Sbjct: 19930 QRVMKSLSLQYSAKDLT---EGKEYTFRVSAENENGEGTPSEITVVARD-DVVAPDLDLK 19985 Query: 432 AFP------KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN 485 P K+N + P + + W D T E V+ T + + Sbjct: 19986 GLPDLCYLAKENSNF-RLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYD 20044 Query: 486 LAESKC--YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLP 543 +S Y IT+ V G+ SIK K P+ GP ++ +V L+W P Sbjct: 20045 CQKSDAGKYTITLKNVAGTKEGT-ISIKVVGKPGIPT-GP-IKFDEVTAEAMTLKWAP-P 20100 Query: 544 VDVQNGFIRNYTIFYRTIIGNETAVNVDS-SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602 D I NY + R + N+ + T + ++ L Y R++A G + Sbjct: 20101 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 20160 Query: 603 G 603 G Sbjct: 20161 G 20161 Score = 49.3 bits (116), Expect = 2e-05 Identities = 95/411 (23%), Positives = 150/411 (36%), Gaps = 64/411 (15%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280 P PP NL+V + S+ L W P I +K Y I R ++ + + + Sbjct: 24116 PGPPQNLAVKEVRKDSAFL--VWEPPIIDGGAKVKNYVIDKRESTRKAYANV---SSKCS 24170 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340 ++SF V++L Y FR+ E G G E P P D S Sbjct: 24171 KTSFKVENLTEGAIYYFRVMAENEFGVGV----PVETVDAVKAAEPPSPPGKVTLTDVSQ 24226 Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTVNATKLTVNLTNDR 395 T + L+W+ P + ++L Y V + +W ++ NA +T + Sbjct: 24227 T----SASLMWEK-PEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV-VTGLSSGQE 24280 Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQAT-HPVM-------------DLK------AFPK 435 Y + N GKSD VL +P T P + DLK P+ Sbjct: 24281 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR 24340 Query: 436 DNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLI 494 N+ WV+ P + + +E E T +++ GN + Y Sbjct: 24341 PNISWVKDGEPLKQTTRVNVE----------------ETATSTVLHIKEGNKDDFGKY-- 24382 Query: 495 TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554 TVT + G + L++ P GP VR +V + V+ W+ P I NY Sbjct: 24383 TVTATNSAGTATENLSVIVLEKPGPPVGP-VRFDEVSADFVVISWEP-PAYTGGCQISNY 24440 Query: 555 TIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGP 604 + R T V+ + T ++ L + T Y R+ A + GK P Sbjct: 24441 IVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFA-ENRYGKSAP 24490 Score = 47.0 bits (110), Expect = 8e-05 Identities = 80/358 (22%), Positives = 137/358 (38%), Gaps = 50/358 (13%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAST 280 P P +L V S+ + ++W P + Y ++ R D TWS + PE Sbjct: 18699 PGPVSDLKV--SDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPE---VK 18753 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340 ++SF V +L P EY FR+ + E G G +D + P P K++ + Sbjct: 18754 KTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKP----VLASDPLSEPDPPRKLEVTE 18809 Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVT--------LTRWKSH--LQNYTVNATKLTVN 390 + L W LPP G +D +T RW + +++ ++ T L Sbjct: 18810 -MTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLK-- 18864 Query: 391 LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV 450 +Y + RN VG +++P + + + + PK +L E T + Sbjct: 18865 -EGKKYKFRVAARNAVG------VSLPR-EAEGVYEAKEQLLPPK--ILMPEQITIKAG- 18913 Query: 451 KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------TVTP 498 KK +E V P + ED V ++L + A+S LI ++T Sbjct: 18914 KKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTA 18973 Query: 499 VYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTI 556 + G + + IK + AP P + + L W +P++ I NY + Sbjct: 18974 ENSSGTDT-QKIKVVVMDAPGPPQPPFDISDIDADACSLSW-HIPLEDGGSNITNYIV 19029 Score = 46.6 bits (109), Expect = 1e-04 Identities = 65/276 (23%), Positives = 111/276 (40%), Gaps = 35/276 (12%) Query: 149 GRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVT 208 G+E T+K++ + A + P S D + +Y + +E N LG T Sbjct: 14424 GKEVKASDRLTMKNDHIS-------AHLEVPKSVRAD-AGIYTITLE------NKLGSAT 14469 Query: 209 SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDAS 267 + IN + P P ++ S+ S KLTW P IL Y ++ R Sbjct: 14470 AS-INVKVIGL--PGPCKDIKA--SDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR 14524 Query: 268 TWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPS 327 T+ P + + S+TV+DL P EY FR++ + + G G ++ E + + +D P Sbjct: 14525 TYI---PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGG---EYIELKNPVIAQD-PK 14577 Query: 328 KAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTV 382 + P ++ H + + WK P ++ KI+ Y + RWK ++ Sbjct: 14578 QPPDPPVDVE-VHNPTAEAMTITWKP-PLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 14635 Query: 383 NATKLTVNLTNDR-YLATLTVRNLVGKSDAAVLTIP 417 T L + Y + N G S+ + T P Sbjct: 14636 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671 Score = 45.8 bits (107), Expect = 2e-04 Identities = 72/342 (21%), Positives = 136/342 (39%), Gaps = 44/342 (12%) Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279 +P PP L V+++ + S++L W P I Y ++ R K + W E + Sbjct: 28545 QPAPPRRLDVVDTSKSSAVL--AWLKPDHDGGSRITGYLLEMRQKGSDFWV----EAGHT 28598 Query: 280 TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339 + +FTV+ L TEY FR++ + G +S+ E S + ++ +I+P+ Sbjct: 28599 KQLTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEP---------QIEPT 28646 Query: 340 HTQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNAT-KLTVNLTNDRYL 397 T QL+ K PF + I WK L+ + T ++++ T DR Sbjct: 28647 ADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWK--LEEMRLKETDRVSITTTKDRTT 28704 Query: 398 AT-------------LTVRNLVG-KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443 T LT+ N G K+ + + + T P+ ++ + ++ + + W Sbjct: 28705 LTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPI-EVSSVSAESCV-LSW 28762 Query: 444 TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYAD 502 P++ I + ++ + T WQ + +V RT ++ +L + Y V+ Sbjct: 28763 GEPKDGGGTEITNY-IVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRF 28821 Query: 503 GPGSPESIKAYLKQ---APPSKGPTVRTKKVGKNEAVLEWDQ 541 G P + + PPS V N + W++ Sbjct: 28822 GVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEE 28863 Score = 44.3 bits (103), Expect = 5e-04 Identities = 94/374 (25%), Positives = 145/374 (38%), Gaps = 39/374 (10%) Query: 241 KLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRI 299 KLTW +P I Y I+ R D W+ P TR + TVQ L Y FRI Sbjct: 16634 KLTWFSPEDDGGSPITNYVIEKRESDRRAWT---PVTYTVTRQNATVQGLIQGKAYFFRI 16690 Query: 300 RCMKEDGKGYWSDWSEE---ASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356 G G + + SE IT +RP TV L W P Sbjct: 16691 AAENSIGMGPFVETSEALVIREPITVPERPEDL--------EVKEVTKNTVTLTWNP-PK 16741 Query: 357 FEANGKILDYEV---TLTRWKSH-LQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSD 410 ++ +I++Y + + K H + N + + K TV D Y ++ N+VG+ Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGK 16801 Query: 411 AAVLTIP-ACDFQATHPVMDLKAFPKDNMLWVE--WTTPRESVK-KYILEWCVLSDKAPC 466 + T P C + P + L K + E T R S K K + W D+A Sbjct: 16802 PSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSW--FKDEADV 16859 Query: 467 ITDWQQEDGTVHRTY----LRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKG 522 + D + T T ++ ++S Y + V G + + + PP G Sbjct: 16860 LEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQ-VNVVDRPGPP-VG 16917 Query: 523 PTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYT--LS 580 P V +V K+ V+ W + P+D I NY I + +G + + V S+ + T +S Sbjct: 16918 P-VSFDEVTKDYMVISW-KPPLDDGGSKITNY-IIEKKEVGKDVWMPVTSASAKTTCKVS 16974 Query: 581 SLTSDTLYMVRMAA 594 L Y+ R+ A Sbjct: 16975 KLLEGKDYIFRIHA 16988 Score = 44.3 bits (103), Expect = 5e-04 Identities = 47/184 (25%), Positives = 76/184 (41%), Gaps = 22/184 (11%) Query: 164 WATHKFAD-CKAKRDTP---TSCTVDYSTVYFVNIE------VWVEAENALGKVTSDHIN 213 W T+ + C+AK S + +T VN+ V A+N G SD + Sbjct: 30754 WITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFG--ISDPLE 30811 Query: 214 FDPVYKVKPNPPHNLSVINSEELSSILK----LTWTNP-SIKSVIILKYNIQYRTKDAST 268 V +K +P ++++ K + W P S I Y ++ R K + Sbjct: 30812 VSSVVIIK-SPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNK 30870 Query: 269 WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSK 328 W + E+ T F+V++L EY FR++C G+ WS+ SE + D P + Sbjct: 30871 WISVTTEEIRET--VFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT--PKSDVPIQ 30926 Query: 329 APSF 332 AP F Sbjct: 30927 APHF 30930 Score = 42.7 bits (99), Expect = 0.002 Identities = 94/374 (25%), Positives = 139/374 (37%), Gaps = 63/374 (16%) Query: 215 DPVYKVKP-NPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQI 272 +PV + P +PP VIN S + L WT P L Y ++ R + +W + Sbjct: 20266 EPVVALDPIDPPGKPEVINITRNS--VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKA 20323 Query: 273 PPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSF 332 + +FTV DL +Y FRIR ++ G S SE I +D +AP+ Sbjct: 20324 NHVNVPEC--AFTVTDLVEGGKYEFRIRA--KNTAGAISAPSESTETIICKDE-YEAPTI 20378 Query: 333 WYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDYEVTLTRWKSHLQNYTVNATKLTVNL 391 +DP+ G L K N IL + + W + + +T + Sbjct: 20379 --VLDPTIKDG-----LTIKAGDTIVLNAISILGKPLPKSSWSK--AGKDIRPSDIT-QI 20428 Query: 392 TNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH------PVMDLKAFP--------KDN 437 T+ + LT++ K DA TI A + T V+D+ P Sbjct: 20429 TSTPTSSMLTIKYATRK-DAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAE 20487 Query: 438 MLWVEWTTPRES----VKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGN 485 + WT P E +K YILE W V+S+ Q V ++GN Sbjct: 20488 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDI-------QSCRHVATKLIQGN 20540 Query: 486 LAESKCYLITVTPVYADGPGSP---ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542 Y+ V+ V G G P E +K + PP V KN A + W + Sbjct: 20541 E-----YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKR- 20594 Query: 543 PVDVQNGFIRNYTI 556 PVD I Y + Sbjct: 20595 PVDDGGSEITGYHV 20608 Score = 42.4 bits (98), Expect = 0.002 Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 32/236 (13%) Query: 150 RETHLETNFTLKSEWATH-----KFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEA---- 200 RE H++ TL+ K K RD PT +D + V +E+ A Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS-KLEIRNAAHEDG 17284 Query: 201 -------ENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNP-SIKSV 252 EN G T ++ + KP PP +L V SE LTW P Sbjct: 17285 GIYSLTVENPAGSKT---VSVKVLVLDKPGPPRDLEV--SEIRKDSCYLTWKEPLDDGGS 17339 Query: 253 IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312 +I Y ++ R ++ WS P S + S + L +Y+FR+ + G+G + + Sbjct: 17340 VITNYVVERRDVASAQWS---PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE 17396 Query: 313 WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368 + + P P + +D T+ V LVW P + I Y V Sbjct: 17397 TPKPIKALD-PLHPPGPPKDLHHVDVDKTE----VSLVWNK-PDRDGGSPITGYLV 17446 Score = 42.0 bits (97), Expect = 0.003 Identities = 83/409 (20%), Positives = 149/409 (36%), Gaps = 58/409 (14%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTAST 280 P PP + + +S + S + L W+ P + Y ++ R + W+ + + T Sbjct: 27167 PGPPAKIRIADSTKSS--ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRT 27224 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340 + + V +LKP Y FR+ + G+G + +E + P + Sbjct: 27225 -TEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIA 27283 Query: 341 TQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQN------YTVNATKLTVNLT- 392 G L+ +K PP T+T W+ +N Y++ T + LT Sbjct: 27284 KAGEDVQVLIPFKGRPP-----------PTVT-WRKDEKNLGSDARYSIENTDSSSLLTI 27331 Query: 393 -----NDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP- 446 ND LT+ N VG+ ++ +++ D A + +K + + + W P Sbjct: 27332 PQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLL-WDPPL 27390 Query: 447 ---RESVKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495 + Y++E W V+S K T ++ D L+E + Sbjct: 27391 IDGGSPIINYVIEKRDATKRTWSVVSHKCSS-TSFKLID-----------LSEKTPFFFR 27438 Query: 496 VTPVYADGPGSPESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554 V G G P +K A P+ + K K +L W + D G + Sbjct: 27439 VLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTK--PDFDGGSVITE 27496 Query: 555 TIFYRTIIGNETAVNVDSSHT-EYTLSSLTSDTLYMVRMAAYTDEGGKD 602 + R G +T + S T E +S L ++ R+ A ++G D Sbjct: 27497 YVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSD 27545 Score = 41.2 bits (95), Expect = 0.004 Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 23/195 (11%) Query: 125 PPEKPKNLSCIVNEGKK-MRCEW-----DGGRET---HLETNFTLKSEWATHKFADCKAK 175 PPE P N +++ K + W DGG ++E T +W H Sbjct: 30328 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTT 30387 Query: 176 RDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV---KPNPPHNLSVIN 232 T T D + + A+N +G + + V K KP+ P L +++ Sbjct: 30388 MYTVTGLVPD------AEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILS 30441 Query: 233 SEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291 + S + L W P IL Y ++YR S W + E + FT+ L Sbjct: 30442 ISKDS--VTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQ--FTIGGLLE 30497 Query: 292 FTEYVFRIRCMKEDG 306 TEY FR+ E G Sbjct: 30498 ATEYEFRVFAENETG 30512 Score = 40.8 bits (94), Expect = 0.006 Identities = 27/113 (23%), Positives = 50/113 (44%), Gaps = 5/113 (4%) Query: 215 DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIP 273 DP++ P PP V ++ S + L W P+ +K Y ++ + + + W ++ Sbjct: 15700 DPIFP--PGPPSCPEV--KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVN 15755 Query: 274 PEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRP 326 D T V +LK +Y FR++ + E G+ SD + E ++ P Sbjct: 15756 EPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEP 15808 Score = 40.8 bits (94), Expect = 0.006 Identities = 105/493 (21%), Positives = 184/493 (37%), Gaps = 68/493 (13%) Query: 147 DGGRETHLETNFTL-KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALG 205 DGG E TN+ + K E + +A A TSC+V+ + + + AEN G Sbjct: 19415 DGGSEI---TNYIVDKRETSRPNWAQVSATVPI-TSCSVE-KLIEGHEYQFRICAENKYG 19469 Query: 206 KVTSDHINFDPVYKVKP-NPPHNLSV-INSEELSSILKLTWTNPSIKSVI-ILKYNIQYR 262 D + +P P +PP + S + ++W P+ I Y ++ R Sbjct: 19470 --VGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR 19527 Query: 263 TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITY 322 A W+++ + T L+ TEY FR+ + + G G SD + +A+ Sbjct: 19528 ETQAVNWTKVNRKPIIERTLKAT--GLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARD 19584 Query: 323 EDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSH------ 376 P P+F D + + +V L W P ++ I+ Y V + R S Sbjct: 19585 PQYPPGPPAFPKVYDTTRS----SVSLSWGK-PAYDGGSPIIGYLVEVKRADSDNWVRCN 19639 Query: 377 -LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK 435 QN ++T + + +Y + N +G SD + +P K +PK Sbjct: 19640 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPS--DVPD------------KHYPK 19685 Query: 436 DNMLWVEWTTPRESVKKYILE-------WCVLSDKAPCITDWQQED------------GT 476 D ++ E + K IL + + + P W + + T Sbjct: 19686 DILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST 19745 Query: 477 VHRTYLR---GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKN 533 T+LR N ++ Y++T+ + G E P V K++ K+ Sbjct: 19746 DFDTFLRCENVNKYDAGKYILTL----ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKD 19801 Query: 534 EAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE-TAVNVDSSHTEYTLSSLTSDTLYMVRM 592 A + W+ +D + I NY + R + V + S T + +++L Y R+ Sbjct: 19802 SAYVTWEPPIIDGGSPII-NYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRV 19860 Query: 593 AAYTDEGGKDGPE 605 A + G D E Sbjct: 19861 FAENEYGIGDPGE 19873 Score = 39.3 bits (90), Expect = 0.017 Identities = 58/237 (24%), Positives = 95/237 (40%), Gaps = 30/237 (12%) Query: 144 CEW-----DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW- 197 C+W DGG E N+TL+ + T ++ T C YS + + + Sbjct: 14820 CKWEPPLDDGGSEI---INYTLEKKDKTKPDSEWIVVTSTLRHCK--YSVTKLIEGKEYL 14874 Query: 198 --VEAENALGK----VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS 251 V AEN G V+ + DP P+ P V + S ++K W P Sbjct: 14875 FRVRAENRFGPGPPCVSKPLVAKDPFGP--PDAPDKPIVEDVTSNSMLVK--WNEPKDNG 14930 Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311 IL Y ++ R +++ WS++ + +++ V L YVFR+ G G +S Sbjct: 14931 SPILGYWLEKREVNSTHWSRVNKSLLNALKAN--VDGLLEGLTYVFRVCAENAAGPGKFS 14988 Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368 S+ + ++ P D S T T++L W+ P F G+I+ Y V Sbjct: 14989 PPSDPKT--AHDPISPPGPPIPRVTDTSST----TIELEWEP-PAFNGGGEIVGYFV 15038 Score = 38.5 bits (88), Expect = 0.029 Identities = 110/488 (22%), Positives = 175/488 (35%), Gaps = 72/488 (14%) Query: 147 DGGRETHLETNFTL-KSEWATHKFADC-KAKRDTPTSCTVDYSTVYFVNIEVWVEAENAL 204 DGG E TN+ L K + +K+ C A + T T + + + V AEN Sbjct: 20103 DGGSEI---TNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYT---FRVSAENKY 20156 Query: 205 GKVTSDHINFDPVYKVKP------NPPHNLSVINSEELSSILKLTWTNPS-IKSVIILKY 257 G + + +P+ P PP N+ + + +S LTWT+P I Y Sbjct: 20157 G--VGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVS----LTWTDPKKTGGSPITGY 20210 Query: 258 NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317 +++++ +++ W + T F V L EY FR+ + G G S SE Sbjct: 20211 HLEFKERNSLLWKRA--NKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV 20268 Query: 318 SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRW--KS 375 + D P K +V L+W T P ++ K+ Y V KS Sbjct: 20269 VALDPIDPPGKPEVI--------NITRNSVTLIW-TEPKYDGGHKLTGYIVEKRDLPSKS 20319 Query: 376 HLQNYTVNATKLTVNLTN----DRYLATLTVRNLVGKSDA---AVLTIPACDFQATHPVM 428 ++ VN + +T+ +Y + +N G A + TI C + P + Sbjct: 20320 WMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETI-ICKDEYEAPTI 20378 Query: 429 DLKAFPKDNMLWVEWTT-------------PRESVKKYILEWCVLSDKAPCITDWQQEDG 475 L KD + T P+ S K + K +D Q Sbjct: 20379 VLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSK--------AGKDIRPSDITQITS 20430 Query: 476 TVHRTYLRGNLAESKC---YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGK 532 T + L A K Y IT T + E +K + P GP V V Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGT---KVEHVKVTVLDVPGPPGP-VEISNVSA 20486 Query: 533 NEAVLEWDQLPVDVQNGFIRNYTIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVR 591 +A L W P++ I++Y + R T T V+ D + + L Y+ R Sbjct: 20487 EKATLTWTP-PLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFR 20545 Query: 592 MAAYTDEG 599 ++A G Sbjct: 20546 VSAVNHYG 20553 Score = 38.1 bits (87), Expect = 0.038 Identities = 78/364 (21%), Positives = 137/364 (37%), Gaps = 31/364 (8%) Query: 195 EVWVEAENALGKVTSDHINFDPVYK----VKPNPPHNLSVINSEELSSILKLTWTNPSIK 250 E V AEN +G + PV+ KP+PP N I++ + + LTW P Sbjct: 17083 EFRVSAENEIG-IGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTT--CNSVDLTWQPPRHD 17139 Query: 251 SVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309 IL Y ++Y+ W + + + + V L+ Y FR+ + G+ Sbjct: 17140 GGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE-- 17197 Query: 310 WSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKIL 364 SD + + +DR + P + + Q + + + K +P + K Sbjct: 17198 -SDPAHVPEPVLVKDR-LEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKE 17255 Query: 365 DYEVTLTRWKSHLQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ 422 D + K+ + + T +KL + D + +LTV N G +V + D Sbjct: 17256 DRDAPT---KARI-DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVL-VLDKP 17310 Query: 423 ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGT-VHRTY 481 +++ KD+ ++ W P + I + V+ + W T +++ Sbjct: 17311 GPPRDLEVSEIRKDS-CYLTWKEPLDDGGSVITNY-VVERRDVASAQWSPLSATSKKKSH 17368 Query: 482 LRGNLAESKCYLITVTP--VYADGP--GSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537 +L E YL V Y GP +P+ IKA PP + V K E L Sbjct: 17369 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 17428 Query: 538 EWDQ 541 W++ Sbjct: 17429 VWNK 17432 Score = 37.7 bits (86), Expect = 0.050 Identities = 67/273 (24%), Positives = 105/273 (38%), Gaps = 38/273 (13%) Query: 356 PFEANGKILDYEVTLTRWKSHLQ------NYTVNATKLTVNLTNDRYLATLTVRNLVGKS 409 P E G +DY + R SHL + + K+T L + Y+ +T N G Sbjct: 25907 PQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVG 25966 Query: 410 DAAV-LTIPACD-FQATHPV--MDLKAFPKDNMLWVEWTTPRES----VKKYILE----- 456 + + I A D F P +++ + K++M W+ P + YI+E Sbjct: 25967 EPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLC-WSRPESDGGSEISGYIIERREKN 26025 Query: 457 ---WCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSP--ESI 510 W V +K P D V T LR G E + Y + SP + Sbjct: 26026 SLRW-VRVNKKPVY------DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAE 26078 Query: 511 KAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV 570 +PPSK V + GK + W + P+ I YT+ Y+ + ++ Sbjct: 26079 DPVFLPSPPSKPKIVDS---GKTTITIAWVK-PLFDGGAPITGYTVEYKKSDDTDWKTSI 26134 Query: 571 DSSH-TEYTLSSLTSDTLYMVRMAAYTDEGGKD 602 S TEYT+S LT+ Y+ R+ + G D Sbjct: 26135 QSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 26167 Score = 36.6 bits (83), Expect = 0.11 Identities = 79/338 (23%), Positives = 118/338 (34%), Gaps = 36/338 (10%) Query: 195 EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254 E +E +N G TS+ I + KP PP I+ + +SI ++W P + Sbjct: 29808 EYTLELKNVTG-TTSETIKV--IILDKPGPPTGPIKIDEIDATSIT-ISWEPPELDGGAP 29863 Query: 255 LK-YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW--S 311 L Y ++ R W P + TRS+F L EYVFR+ G G + S Sbjct: 29864 LSGYVVEQRDAHRPGWL---PVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQS 29920 Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDY---- 366 + E S I P F D + L W PP + G ++ Y Sbjct: 29921 EVIECRSSIRIPGPPETLQIFDVSRD--------GMTLTW--YPPEDDGGSQVTGYIVER 29970 Query: 367 -EVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDF 421 EV RW K + +T LT L + + + R GK I A D Sbjct: 29971 KEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARG-SGKPSRPSKPIVAMDP 30029 Query: 422 QAT--HPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQ--EDGTV 477 A P + + W+ P + + + + K +W + T Sbjct: 30030 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKCNTTPTK 30088 Query: 478 HRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK 515 R Y +L + Y V A GPG P + +K Sbjct: 30089 IREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVK 30126 Score = 35.4 bits (80), Expect = 0.25 Identities = 77/319 (24%), Positives = 122/319 (38%), Gaps = 54/319 (16%) Query: 221 KPNPPHNLSVINSEELSSI-LKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTA 278 +P PP + I E +S+ + L+W P I Y I+ R + TW + E Sbjct: 16216 RPGPP--VGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKE 16273 Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYE-----DRPSKAPSFW 333 T +T+ L EYVFRI + G G D E + + D+P+ + Sbjct: 16274 CT---YTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVS---- 16326 Query: 334 YKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWK----SHLQNYTVNA 384 S T+ TV W+ P ++ + Y + T RWK ++ T+ Sbjct: 16327 -----SVTRNSMTVN--WEE-PEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGV 16378 Query: 385 T-KLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDL-KAFPK-----DN 437 + K+T + Y + N G A++ + PA A P+ FPK + Sbjct: 16379 SYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPA---TARDPIAPPGPPFPKVTDWTKS 16435 Query: 438 MLWVEWTTPRE----SVKKYILEWCVLSDKAPCITDWQQ-EDGTVHRTYL-RGNLAESKC 491 +EW+ P + V YI+E+ K +W++ +D V T L L E Sbjct: 16436 SADLEWSPPLKDGGSKVTGYIVEY-----KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAF 16490 Query: 492 YLITVTPVYADGPGSPESI 510 Y V V G G P + Sbjct: 16491 YKFRVRAVNIAGIGEPGEV 16509 Score = 35.4 bits (80), Expect = 0.25 Identities = 61/273 (22%), Positives = 93/273 (34%), Gaps = 24/273 (8%) Query: 349 LVWKTLPPFEANG-KILDY-----EVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTV 402 L W+ PP E G +I +Y E + W + + + + Y + Sbjct: 19407 LSWE--PPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICA 19464 Query: 403 RNLVGKSDAAVLTIPACDFQATHPVMD-----LKAFPKDNMLWVEWTTPRESVKKYILEW 457 N G D V T PA P + KD+M V W P + I + Sbjct: 19465 ENKYGVGDP-VFTEPAIAKNPYDPPGRCDPPVISNITKDHMT-VSWKPPADDGGSPITGY 19522 Query: 458 CVLSDKAPCITDWQQEDGT--VHRTYLRGNLAESKCYLITVTPVYADGPGSPE--SIKAY 513 +L + +W + + + RT L E Y VT + GPG P S AY Sbjct: 19523 -LLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAY 19581 Query: 514 LK--QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVD 571 + Q PP + ++ L W + D + I R N N+ Sbjct: 19582 ARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLP 19641 Query: 572 SS--HTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602 + T + ++ L DT Y R+ A G D Sbjct: 19642 QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSD 19674 Score = 35.0 bits (79), Expect = 0.32 Identities = 40/140 (28%), Positives = 56/140 (40%), Gaps = 17/140 (12%) Query: 198 VEAENALGKVTSDHINFDPVYKVKP--------NPPHNLSVINSEELSSILKLTWTNPSI 249 V AEN G ++ + +PV P NPP L V S + L+W+ P Sbjct: 30302 VSAENQFG-ISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSS-----VSLSWSRPKD 30355 Query: 250 KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 + Y I+ K+ ST + T T + +TV L P EY FRI + G Sbjct: 30356 DGGSRVTGYYIE--RKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLS 30413 Query: 309 YWSDWSEEASGITYEDRPSK 328 S SE D+PS+ Sbjct: 30414 ETSPASEPVVCKDPFDKPSQ 30433 Score = 33.9 bits (76), Expect = 0.72 Identities = 84/373 (22%), Positives = 131/373 (35%), Gaps = 54/373 (14%) Query: 198 VEAENALGKVTSDHINFDPVYKVKP----NPPHNLSVINSEELSSILKLTWTNPSIKS-V 252 V+AEN +G + + PV P PP N V+++ + S + L W P Sbjct: 18470 VKAENEIG-IGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHS--ITLGWGKPVYDGGA 18526 Query: 253 IILKYNIQYRTK--DAST---WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307 I+ Y ++ R K DAS W + R FTV L EY FR+ + G Sbjct: 18527 PIIGYVVEMRPKIADASPDEGWKRCNAA-AQLVRKEFTVTSLDENQEYEFRVCAQNQVGI 18585 Query: 308 GYWSDWSEEASGITYEDRP---------------SKAPSFWYKIDPSHTQGYRTVQLVWK 352 G ++ E + P + P + I +G ++ W+ Sbjct: 18586 GRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAI----VRGRPAPKVTWR 18641 Query: 353 TLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAA 412 + + + +V L + L N+T+ +D +LT+ N G+ A Sbjct: 18642 KV---GIDNVVRKGQVDLVDTMAFL--VIPNSTR------DDSGKYSLTLVNPAGEK-AV 18689 Query: 413 VLTIPACDFQATHPVMDLKAFP-KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQ 471 + + D PV DLK V W P + + V +A T W Sbjct: 18690 FVNVRVLD--TPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT-WS 18746 Query: 472 QEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP----TVR 526 V +T NL Y VT V GPG P + + + P P + Sbjct: 18747 TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLE 18806 Query: 527 TKKVGKNEAVLEW 539 ++ KN A L W Sbjct: 18807 VTEMTKNSATLAW 18819 Score = 33.1 bits (74), Expect = 1.2 Identities = 87/413 (21%), Positives = 149/413 (36%), Gaps = 50/413 (12%) Query: 135 IVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNI 194 +VN G+ R E D + L T L+ + + A C+ K + + + Sbjct: 23636 VVNAGETFRLEADVHGKP-LPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694 Query: 195 EVWVEAENALGKVTSDHINFDPVYKV--KPNPPHN---LSVINSEELSSILKLTWTNP-S 248 + + A N G + F KV +P PP ++ + SE+ S LTW+ P Sbjct: 23695 QYILRASNVAGSKS-----FPVNVKVLDRPGPPEGPVQVTGVTSEKCS----LTWSPPLQ 23745 Query: 249 IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 I Y ++ R W+ + E + S V L EYVFRI + + G G Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTN---SLKVTKLLEGNEYVFRIMAVNKYGVG 23802 Query: 309 YWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368 S P P ++ ++ ++ + W P + +I+ Y + Sbjct: 23803 -----EPLESAPVLMKNPFVLPGPPKSLEVTNI-AKDSMTVCWNR-PDSDGGSEIIGY-I 23854 Query: 369 TLTRWKSHLQNYTVNATKLT------VNLTND-RYLATLTVRNL--VGKSDAAVLTIPAC 419 R +S ++ N ++T LT D Y ++ N VG+ A + AC Sbjct: 23855 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 23914 Query: 420 D--FQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKYILEWCVLSDKAPCITDWQ-- 471 D F+ P N + + W P + Y++E C ++ +WQ Sbjct: 23915 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEE-----EWQIV 23969 Query: 472 -QEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP 523 + G + L E + Y I V + G G S+ +K + P Sbjct: 23970 TPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAP 24022 Score = 32.7 bits (73), Expect = 1.6 Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 11/120 (9%) Query: 195 EVWVEAENALG-----KVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249 E V AEN G + + + D Y P PP N V ++ + S+ L W P Sbjct: 20643 EFRVSAENRAGIGPPSEASDSVLMKDAAYP--PGPPSNPHVTDTTKKSA--SLAWGKPHY 20698 Query: 250 KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308 + I Y ++++ W + TA + F V DL+ +Y FRI + + G G Sbjct: 20699 DGGLEITGYVVEHQKVGDEAWIK-DTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757 Score = 32.3 bits (72), Expect = 2.1 Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 9/104 (8%) Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIK-SVIILKYNIQYRTKDASTWSQIPPEDTAST 280 P+PP L VIN + ++ LK WT P I Y ++ R W + DT Sbjct: 14084 PSPPRWLEVINITKNTADLK--WTVPEKDGGSPITNYIVEKRDVRRKGWQTV---DTTVK 14138 Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYED 324 + TV L + YVFR+ G+ SD++E + +D Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQ---SDYTEIEDSVLAKD 14179 Score = 32.3 bits (72), Expect = 2.1 Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 8/113 (7%) Query: 198 VEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILK 256 + N +G+ T+ + + V KP+PP + SI L+W P I Sbjct: 23302 ITVANVVGQKTA---SIEIVTLDKPDPPKGPVKFDDVSAESIT-LSWNPPLYTGGCQITN 23357 Query: 257 YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309 Y +Q R + W + R++ V LK TEY FRI G+ + Sbjct: 23358 YIVQKRDTTTTVWDVV---SATVARTTLKVTKLKTGTEYQFRIFAENRYGQSF 23407 Score = 31.2 bits (69), Expect = 4.6 Identities = 31/149 (20%), Positives = 57/149 (38%), Gaps = 13/149 (8%) Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279 +P PP + + E + ++W P I Y ++ + ++TW + A Sbjct: 25487 RPGPPGPIRI--DEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV---SQAV 25541 Query: 280 TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339 R+S + L +EY FR+ GK +S+ S A Y P P P Sbjct: 25542 ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESS--AVVAEYPFSPPGPPG-----TPK 25594 Query: 340 HTQGYRTVQLVWKTLPPFEANGKILDYEV 368 ++ LV +P + +++ Y + Sbjct: 25595 VVHATKSTMLVTWQVPVNDGGSRVIGYHL 25623 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.131 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 38,263,332 Number of Sequences: 37866 Number of extensions: 1769093 Number of successful extensions: 6217 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 53 Number of HSP's successfully gapped in prelim test: 145 Number of HSP's that attempted gapping in prelim test: 5218 Number of HSP's gapped (non-prelim): 854 length of query: 918 length of database: 18,247,518 effective HSP length: 111 effective length of query: 807 effective length of database: 14,044,392 effective search space: 11333824344 effective search space used: 11333824344 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.