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Search of human proteins with 28558993
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 1649 0.0
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 1631 0.0
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 79 1e-14
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 79 1e-14
gi|83415184 transmembrane and tetratricopeptide repeat containin... 65 3e-10
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 60 1e-08
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 59 2e-08
gi|118402596 cell division cycle protein 23 [Homo sapiens] 59 2e-08
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 57 5e-08
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 56 2e-07
gi|22749211 transmembrane and tetratricopeptide repeat containin... 53 1e-06
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 52 2e-06
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 51 4e-06
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 51 4e-06
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 51 5e-06
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 49 3e-05
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 49 3e-05
gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] 48 3e-05
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 47 1e-04
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 47 1e-04
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 47 1e-04
gi|224809432 transmembrane and tetratricopeptide repeat containi... 46 2e-04
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 44 8e-04
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 44 8e-04
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 44 8e-04
gi|164519122 LGN protein [Homo sapiens] 44 8e-04
gi|6912398 general transcription factor IIIC, polypeptide 3, 102... 42 0.002
gi|6912630 interferon-induced protein with tetratricopeptide rep... 41 0.004
gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Ho... 40 0.007
gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [H... 40 0.007
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 1649 bits (4270), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPP 60
MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPP
Sbjct: 1 MKFTNTKVQMMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPP 60
Query: 61 ITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGS 120
ITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGS
Sbjct: 61 ITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGS 120
Query: 121 AFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDA 180
AFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDA
Sbjct: 121 AFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDA 180
Query: 181 GRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSN 240
GRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSN
Sbjct: 181 GRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSN 240
Query: 241 AGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDA 300
AGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDA
Sbjct: 241 AGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDA 300
Query: 301 INSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPH 360
INSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPH
Sbjct: 301 INSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPH 360
Query: 361 TNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYV 420
TNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYV
Sbjct: 361 TNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYV 420
Query: 421 ELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASS 480
ELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASS
Sbjct: 421 ELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASS 480
Query: 481 YADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540
YADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKL
Sbjct: 481 YADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540
Query: 541 NRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSK 600
NRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSK
Sbjct: 541 NRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSK 600
Query: 601 LGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP 660
LGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP
Sbjct: 601 LGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP 660
Query: 661 TQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYAR 720
TQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYAR
Sbjct: 661 TQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYAR 720
Query: 721 KLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPG 780
KLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPG
Sbjct: 721 KLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPG 780
Query: 781 TNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 833
TNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Sbjct: 781 TNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 833
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 1631 bits (4224), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 10 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 69
MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA
Sbjct: 1 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 60
Query: 70 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 129
VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR
Sbjct: 61 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 120
Query: 130 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 189
GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR
Sbjct: 121 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 180
Query: 190 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 249
QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG
Sbjct: 181 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 240
Query: 250 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 309
NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS
Sbjct: 241 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 300
Query: 310 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 369
MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK
Sbjct: 301 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 360
Query: 370 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 429
NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN
Sbjct: 361 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 420
Query: 430 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 489
KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD
Sbjct: 421 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
Query: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC
Sbjct: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
Query: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG
Sbjct: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
Query: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 669
DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV
Sbjct: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 660
Query: 670 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 729
ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK
Sbjct: 661 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 720
Query: 730 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 789
EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS
Sbjct: 721 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 780
Query: 790 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 833
NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Sbjct: 781 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 824
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 79.3 bits (194), Expect = 1e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 240 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 299
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 44 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 97
Query: 300 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 358
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 152
Query: 359 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 418
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 153 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 202
Query: 419 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 478
+ E A L+ N Y+ NL + + F +A
Sbjct: 203 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 234
Query: 479 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 538
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
Query: 539 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 598
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
Query: 599 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 658
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 414
Query: 659 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 718
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 415 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 472
Query: 719 ARKLKRL 725
++K+L
Sbjct: 473 DERMKKL 479
Score = 30.0 bits (66), Expect = 9.2
Identities = 23/133 (17%), Positives = 61/133 (45%)
Query: 459 SAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKE 518
+AA +NL+++ +A + A+ A +N GNT+ D + A + Y
Sbjct: 351 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 410
Query: 519 ALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPS 578
A++ + + +A N+ ++ + EA+ + + + + +A+ +++ + +
Sbjct: 411 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 470
Query: 579 QAIEWLMQVVSVI 591
E + ++VS++
Sbjct: 471 DYDERMKKLVSIV 483
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 79.3 bits (194), Expect = 1e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 240 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 299
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 54 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 107
Query: 300 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 358
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 108 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 162
Query: 359 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 418
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 163 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 212
Query: 419 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 478
+ E A L+ N Y+ NL + + F +A
Sbjct: 213 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 244
Query: 479 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 538
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 245 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 304
Query: 539 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 598
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 305 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 364
Query: 599 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 658
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 365 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 424
Query: 659 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 718
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 425 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 482
Query: 719 ARKLKRL 725
++K+L
Sbjct: 483 DERMKKL 489
Score = 30.0 bits (66), Expect = 9.2
Identities = 23/133 (17%), Positives = 61/133 (45%)
Query: 459 SAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKE 518
+AA +NL+++ +A + A+ A +N GNT+ D + A + Y
Sbjct: 361 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 420
Query: 519 ALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPS 578
A++ + + +A N+ ++ + EA+ + + + + +A+ +++ + +
Sbjct: 421 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 480
Query: 579 QAIEWLMQVVSVI 591
E + ++VS++
Sbjct: 481 DYDERMKKLVSIV 493
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 65.1 bits (157), Expect = 3e-10
Identities = 55/239 (23%), Positives = 107/239 (44%), Gaps = 4/239 (1%)
Query: 462 ATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALR 521
A+ L+ L + +D A+A Y A+ + AL N GN + + E+A K++++
Sbjct: 409 ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
Query: 522 NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI 581
+A ++ + R EA + + +S+++ P +A+
Sbjct: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
Query: 582 EWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID 641
Q + + P+ + LG LY G+ S A ++Y + + E++ LGA Y +
Sbjct: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-KAEILSPLGALYYN 587
Query: 642 TQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 700
T +E+A+Q ++ A+ +QP+Q + +L +A G ++A K T+ E CL
Sbjct: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEA---EKMTNHIVSEETGCL 643
Score = 47.0 bits (110), Expect = 7e-05
Identities = 41/197 (20%), Positives = 75/197 (38%), Gaps = 3/197 (1%)
Query: 491 YNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
+N N N + G ++A Y+ AL+ AL N+G
Sbjct: 373 HNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA 432
Query: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
L+LH L+ + N+ + E +AI L + P S L L +
Sbjct: 433 LQLHP---QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQER 489
Query: 611 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 670
+A + Y + P + ++ G + +DT EKA+ ++++A + P+ + +
Sbjct: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549
Query: 671 SCFRRSGNYQKALDTYK 687
+R G A + YK
Sbjct: 550 RLYRSLGENSMAEEWYK 566
Score = 42.4 bits (98), Expect = 0.002
Identities = 88/432 (20%), Positives = 161/432 (37%), Gaps = 68/432 (15%)
Query: 247 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEH 306
N N Q +AI YR AL P + N+G ++A Y+
Sbjct: 380 NYANFLKDQGRNKEAIYHYRTALKLYPR-----HASALNNLGTL---TRDTAEAKMYYQR 431
Query: 307 IMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTE 366
+ + P +N + F +G+ K ++ ++ IT L D KY D +++L +
Sbjct: 432 ALQLHPQ----HNRAL--FNLGNLLKSQEKKEEAIT--LLKDSIKYGPEFADAYSSLASL 483
Query: 367 AIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDL 426
E+ER AE+ T K +L N+
Sbjct: 484 LA--------EQERFKEAEEIYQTGIK---------------------NCPDSSDLHNNY 514
Query: 427 EINKAVTYLRQK---DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 483
+ T L +K Y QA+++ S A NL LY + + A +
Sbjct: 515 GVFLVDTGLPEKAVAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYK 566
Query: 484 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 543
A+ + L+ G + G YE+A + Y+EA S E + + +
Sbjct: 567 RALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625
Query: 544 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKL-- 601
EA + + E ++ IY EN +A++ + + + + P DP+V+S+L
Sbjct: 626 KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
Query: 602 --GELYDREGDKSQAFQYYYESYRYFP------CNIEVIEWLGAYYIDTQ-FWEKAIQYF 652
G + +AF+ Y + + P N+ I+ + Y+ + ++E+A+Q
Sbjct: 686 TKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLV 745
Query: 653 ERASLIQPTQVK 664
+ L++ K
Sbjct: 746 PDSKLLKENLAK 757
Score = 34.3 bits (77), Expect = 0.49
Identities = 30/156 (19%), Positives = 62/156 (39%), Gaps = 15/156 (9%)
Query: 588 VSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK 647
V +P + +V +G +A +Y + + +P + + LG DT +
Sbjct: 368 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA---E 424
Query: 648 AIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLC 707
A Y++RA + P + + + + ++A+ KD+ + PE + L L
Sbjct: 425 AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLL 484
Query: 708 TDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGS 743
+ +R ++ +EI + IK+ D S
Sbjct: 485 AE------------QERFKEAEEIYQTGIKNCPDSS 508
Score = 33.1 bits (74), Expect = 1.1
Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 7/129 (5%)
Query: 211 NLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALD 270
+LAS + E + EA YQ +KN ++ L N G + KA+ Y+ A+
Sbjct: 479 SLASLLAEQERFKEAEEIYQTGIKN--CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
Query: 271 QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDR 330
PS + M N+G + G+ S A Y+ + +A + L Y+ G
Sbjct: 537 LSPSHH-----VAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRY 591
Query: 331 EKMKKAFQK 339
E+ + +Q+
Sbjct: 592 EEALQIYQE 600
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 59.7 bits (143), Expect = 1e-08
Identities = 66/290 (22%), Positives = 114/290 (39%), Gaps = 47/290 (16%)
Query: 472 GKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSC-TEAL 530
G QA + +N N AL K F DY A +YK+ALR + C E
Sbjct: 142 GDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVR 201
Query: 531 YNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVS- 589
+G + KLN+L++A F + + L +A + EL + +I+ +Q++S
Sbjct: 202 LGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLA-VLELNNKEADSIKNGVQLLSR 260
Query: 590 ---VIPTDPQVLS-------------------------------------KLGELYDREG 609
+ P++P VL+ +L + +
Sbjct: 261 AYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQE 320
Query: 610 DKSQAFQYYYESYRYFPCNIEV-IEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLM 668
D QAFQYYY++ ++ + + LG YI E A Q FE+ P + +
Sbjct: 321 DYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKI 380
Query: 669 VASCFRRSGNYQK---ALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDA 715
+ S + S + +K A K ++P++VE L ++ ++ A
Sbjct: 381 LGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGA 430
Score = 46.6 bits (109), Expect = 1e-04
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 36/218 (16%)
Query: 485 AVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLD 544
A D NP L + N F DY K A N EA+
Sbjct: 261 AYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTE--VEAM-------------- 304
Query: 545 EALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV-LSKLGE 603
AE YQ+A + + E+ QA ++ Q + + LG+
Sbjct: 305 ---------------QAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQ 349
Query: 604 LYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK---AIQYFERASLIQP 660
+Y GDK A Q + + + +P N E ++ LG+ Y ++ EK A + ++ + P
Sbjct: 350 MYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYP 409
Query: 661 TQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVE 698
V+ + +A ++ + Q AL Y R E V+
Sbjct: 410 DDVEAWIELAQILEQT-DIQGALSAYGTATRILQEKVQ 446
Score = 36.2 bits (82), Expect = 0.13
Identities = 46/236 (19%), Positives = 86/236 (36%), Gaps = 55/236 (23%)
Query: 508 DYEKAAEFYKEALR-NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 566
DY++A ++Y +A + SS + +G Y + A CF K+ N+ E +
Sbjct: 321 DYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKI 380
Query: 567 IANIYELMEN------------------PSQAIEWLMQVVSVIPTD-------------- 594
+ ++Y E+ P W+ + TD
Sbjct: 381 LGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRI 440
Query: 595 ----------PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIE-WLGAYYIDTQ 643
P++L+ +G L+ R G+ +A +Y+ S E E + A + T
Sbjct: 441 LQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTS 500
Query: 644 F-----WEKAIQYFERASLIQ------PTQVKWQLMVASCFRRSGNYQKALDTYKD 688
+ +E ++ E L + P V L + + R GN+ +A D +K+
Sbjct: 501 YNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKE 556
Score = 33.1 bits (74), Expect = 1.1
Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 13/174 (7%)
Query: 509 YEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL------------HAI 556
Y A +E ++ D E L N+G + +L L EA FL H
Sbjct: 434 YGTATRILQEKVQADVP-PEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYY 492
Query: 557 LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQ 616
S Y +A +YE M +A + ++ P +LG + +G+ +A
Sbjct: 493 NAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASD 552
Query: 617 YYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 670
++ E+ + + + +G ++ Q W + FER TQ M+A
Sbjct: 553 WFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLA 606
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/62 (29%), Positives = 29/62 (46%)
Query: 510 EKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIAN 569
++A YK+ LRND+ A IG EA D F ++ + ++V +A+
Sbjct: 630 DRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAH 689
Query: 570 IY 571
IY
Sbjct: 690 IY 691
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 34/223 (15%)
Query: 508 DYEKAAEFYKEALRNDSS-CTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 566
DYE KE L+ C A+Y L + + E+L+ F + SA+ L Q
Sbjct: 47 DYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQ 106
Query: 567 IANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELY----------DR--------- 607
+A L+ AIE + + D ++ LG Y D+
Sbjct: 107 VARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNR 166
Query: 608 --------------EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFE 653
EGD +A + Y ++ + P N E++ LG Y+ ++KA ++
Sbjct: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
Query: 654 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPEN 696
A PT K L S + G++ AL Y+ PE+
Sbjct: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPES 269
Score = 53.5 bits (127), Expect = 8e-07
Identities = 47/194 (24%), Positives = 86/194 (44%), Gaps = 5/194 (2%)
Query: 496 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLH- 554
L ++F G ++ A E Y EA + + E +N+G+ Y L + ++A D +LH
Sbjct: 104 LKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD---QLHN 160
Query: 555 AILRNSAEVLY-QIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 613
A+ N ++ Y + I+ L + +AIE + V P + ++L+ LG LY + G +
Sbjct: 161 ALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQK 220
Query: 614 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 673
AF++ + Y P N + I G+ ++ A+ + + P + CF
Sbjct: 221 AFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280
Query: 674 RRSGNYQKALDTYK 687
Y A+ K
Sbjct: 281 FGKKKYVAAISCLK 294
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/249 (19%), Positives = 96/249 (38%), Gaps = 9/249 (3%)
Query: 440 YNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNK 499
YN+A + L +KD + NL Y K F +A A+N +R++ +
Sbjct: 124 YNEAAK----LNQKDWEISH----NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIM-L 174
Query: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
G GD +KA E YK+A+ TE L +GL Y +L +A +
Sbjct: 175 GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPT 234
Query: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
+ + + ++ + + A+ V +P P + + +G + + A
Sbjct: 235 NYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLK 294
Query: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNY 679
+ P + +++ LG ++ Q + A + A QP + +++A +
Sbjct: 295 RANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDI 354
Query: 680 QKALDTYKD 688
+ A Y +
Sbjct: 355 ENAKRAYAE 363
Score = 44.7 bits (104), Expect = 4e-04
Identities = 61/274 (22%), Positives = 111/274 (40%), Gaps = 20/274 (7%)
Query: 371 DHLRQMER------ERKAMAEKYIMTSAKLIAPVIETSFAAG--YDWCVEVVKASQYVEL 422
D+L+Q+ R + KA E Y +AKL E S G Y + + KA +L
Sbjct: 102 DNLKQVARSLFLLGKHKAAIEVY-NEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD--QL 158
Query: 423 ANDLEINKA-VTY-------LRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD 474
N L +N+ +TY L + D ++A+E+ K + S + T L LY
Sbjct: 159 HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEF-SPENTELLTTLGLLYLQLGI 217
Query: 475 FAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIG 534
+ +A + A+ D N A+ G+ + +GD++ A Y+ NIG
Sbjct: 218 YQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIG 277
Query: 535 LTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTD 594
+ + + A+ C + + + ++LY + ++ M+ + A +L ++ P
Sbjct: 278 MCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM 337
Query: 595 PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCN 628
++ L D A + Y E+ CN
Sbjct: 338 GELYMLLAVALTNLEDIENAKRAYAEAVHLDKCN 371
Score = 39.7 bits (91), Expect = 0.012
Identities = 35/149 (23%), Positives = 59/149 (39%), Gaps = 1/149 (0%)
Query: 564 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 623
+Y A I+ L N +++E + P L ++ G A + Y E+ +
Sbjct: 70 IYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAK 129
Query: 624 YFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKAL 683
+ E+ LG YI + + KA A + + + +M+ G+ KA+
Sbjct: 130 LNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTY-IMLGKIHLLEGDLDKAI 188
Query: 684 DTYKDTHRKFPENVECLRFLVRLCTDLGL 712
+ YK PEN E L L L LG+
Sbjct: 189 EVYKKAVEFSPENTELLTTLGLLYLQLGI 217
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 3/193 (1%)
Query: 431 AVTYLRQKDYNQAVEILKVLEKKDS-RVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 489
AV Y +D ++A+ I L K+D R+++ S L Y+ ++ S A D
Sbjct: 270 AVAYHNIRDIDKALSIFNELRKQDPYRIENM--DTFSNLLYVRSMKSELSYLAHNLCEID 327
Query: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
+Y GN +EKAA +++ AL+ + A +G Y ++ A+
Sbjct: 328 KYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQA 387
Query: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
+ + + Y + YE+++ P + + + + P D ++L LGE Y++
Sbjct: 388 YRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLN 447
Query: 610 DKSQAFQYYYESY 622
+A + Y+ +Y
Sbjct: 448 QLVEAKKCYWRAY 460
Score = 31.6 bits (70), Expect = 3.2
Identities = 31/152 (20%), Positives = 59/152 (38%), Gaps = 1/152 (0%)
Query: 537 YEKLNRLDEALDCFLKLHAI-LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDP 595
Y +L ++EAL + L + S+ ++ QIA Y + + +A+ ++ P
Sbjct: 238 YTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
Query: 596 QVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
+ + L KS+ + +E +G YY EKA YF+RA
Sbjct: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
Query: 656 SLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 687
+ P + ++ + N A+ Y+
Sbjct: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYR 389
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 57.4 bits (137), Expect = 5e-08
Identities = 107/516 (20%), Positives = 198/516 (38%), Gaps = 84/516 (16%)
Query: 211 NLASQYSVNEMYAEALNTYQ----VIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
NLA Y + AL YQ + + + + N+GN + + Y +A +Y
Sbjct: 559 NLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYE 618
Query: 267 MALDQVPSV-NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL-------KAGY 318
L P + + + K+ N+G G Y +A+ YE +++A +L KA
Sbjct: 619 QYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYC 678
Query: 319 NLTICYFAIGDREKMKKAFQKLITVPLEIDE------------DKYISPSDDPHTNLVTE 366
NL + + A+ + K ++ + L+++ ++ D +I D +
Sbjct: 679 NLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKD------ING 732
Query: 367 AIK----NDHLRQMERERKAMAEKY--IMTSAKLIAPVIETSFAAGYDWCVEVVKASQYV 420
AIK L ++R+ A Y + T+ ++I + A GY E+ +
Sbjct: 733 AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQ---KYDKALGYH-TQELEVYQELS 788
Query: 421 ELANDLEI--NKAVTYLRQKDYNQAV----EILKVLEK-KDSRVKSAAATNL-------- 465
+L + + A Y+ Y A E L + +K KD +++ N+
Sbjct: 789 DLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMN 848
Query: 466 ---SALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYK----- 517
A+ Y + A + DR A N G+ A GDYE+A ++Y+
Sbjct: 849 VMEEAIGYFEQQLAMLQQLSGNESVLDR--GRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
Query: 518 -EALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILR------NSAEVLYQIANI 570
++L +A +G + + L +AL CF K + N A+ ++ ++
Sbjct: 907 AQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSL 966
Query: 571 YELMENPSQAIEWLMQVVSVI------PTDPQVLSKLGELYDREGDKSQAFQYYY----- 619
+ + N QAI L + +++ + LG +Y + G+ A QY+
Sbjct: 967 HSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQI 1026
Query: 620 -ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFER 654
E C LG Y +E+A+ Y E+
Sbjct: 1027 AEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
Score = 52.8 bits (125), Expect = 1e-06
Identities = 103/519 (19%), Positives = 197/519 (37%), Gaps = 95/519 (18%)
Query: 248 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 306
+ + Y N K+ + + LD ++ Q + N+G F G Y +A+ ++ H
Sbjct: 240 LSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRH 299
Query: 307 IMSMAPNLK-------AGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDP 359
+ +A LK A +L Y AIGD + ++ + + + +D+ +
Sbjct: 300 QLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQ-SKDELSEARELG 358
Query: 360 HTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIE-----TSFAAGYDWCVEVV 414
+ V ++ + E + + AK + E ++ + Y +
Sbjct: 359 NMGAV-------YIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD 411
Query: 415 KASQY----VELANDLEINKAVTYLRQKDYNQAVEILKVLEK---------------KDS 455
KA Y +ELA +L + KA+ A ++ LE+ KD
Sbjct: 412 KAMSYHNYVLELAQEL-MEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDR 470
Query: 456 RVKSAAATNLSALYYMGKDFAQA----SSYADIAVNSDRY--NPAALTNKGNTVFANGDY 509
+ A++NL ++ M D+ A ++ IA Y A N GN A G Y
Sbjct: 471 AAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMY 530
Query: 510 EKAAEFYKEALR-----NDSSCTEALY-NIGLTYEKLNRLDEALDCFLKLHAILRNSAEV 563
++A +++++ L+ ND + + + N+ + Y+ L D AL + +N +
Sbjct: 531 DQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHY-------QNHLNI 583
Query: 564 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 623
++ + I ++ + LS LG + G+ QA YY + R
Sbjct: 584 ARELRD---------------------IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLR 622
Query: 624 YFP------CNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSG 677
P +V LG + +++A++Y+E+ L + +L A + G
Sbjct: 623 LAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQ-DLALAKDLHDKLSQAKAYCNLG 681
Query: 678 NYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQ 716
KAL F + EC ++L+ L L A+
Sbjct: 682 LAFKAL-------LNFSKAEECQKYLLSLAQSLNNSQAK 713
Score = 47.4 bits (111), Expect = 6e-05
Identities = 85/432 (19%), Positives = 159/432 (36%), Gaps = 110/432 (25%)
Query: 247 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNK----------------------------- 277
NMGN Y Y +A+K++R L VN
Sbjct: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
Query: 278 ------------QMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL-------KAGY 318
Q + + N+G G+Y A YE + +AP+L K +
Sbjct: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCH 638
Query: 319 NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMER 378
NL ++ +G+ ++ K +++ + + ++ DK + L +A+ N
Sbjct: 639 NLGYAHYCLGNYQEAVKYYEQDLALAKDL-HDKLSQAKAYCNLGLAFKALLN-------F 690
Query: 379 ERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQK 438
+ +KY+++ A+ + A G + + K +IN A+ + Q
Sbjct: 691 SKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKK----------DINGAIKFYEQ- 739
Query: 439 DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSY--ADIAVNSDRYN-PAA 495
++ + KD R++++A L Y M + + +A Y ++ V + + P
Sbjct: 740 ------QLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGE 793
Query: 496 LTNKGN---TVFANGDYEKAAEFYKEAL-----RNDSSCTEALY-NIGLTYEKLNRLDEA 546
G+ A G Y A + Y+E L D S +Y N+G+T +N ++EA
Sbjct: 794 CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEA 853
Query: 547 LDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYD 606
+ F + Q+A + +L N S + + LG+ Y+
Sbjct: 854 IGYFEQ-------------QLAMLQQLSGNES------------VLDRGRAYGNLGDCYE 888
Query: 607 REGDKSQAFQYY 618
GD +A +YY
Sbjct: 889 ALGDYEEAIKYY 900
Score = 46.6 bits (109), Expect = 1e-04
Identities = 82/402 (20%), Positives = 158/402 (39%), Gaps = 86/402 (21%)
Query: 212 LASQYSVNEMYAEAL--NTYQVIVKNKMFSNAGILKMN--MGNIYLKQRNYSKAIKFYRM 267
L + Y + + Y +AL +T ++ V ++ G + + + +Y+ Y+ A K Y
Sbjct: 760 LGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEE 819
Query: 268 ALDQVPSV-NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL----------KA 316
LD + + + ++ N+G+T + +AI +E ++M L +A
Sbjct: 820 QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRA 879
Query: 317 GYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQM 376
NL CY A+GD E+ K +++ ++V ++ + + + + N H R M
Sbjct: 880 YGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKA--------YRGLGNGH-RAM 930
Query: 377 ERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLR 436
++A+ E ++ KA Y EL + + +
Sbjct: 931 GSLQQALV-------------CFEKRLVVAHELGEAFNKAQAYGELGS--------LHSQ 969
Query: 437 QKDYNQAVEILK-----VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRY 491
+Y QA+ L+ + KD ++S AA L +Y ++ A Y +
Sbjct: 970 LGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL------- 1022
Query: 492 NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALY-NIGLTYEKLNRLDEAL--- 547
D + A E N+ +C Y N+GLTYE L + A+
Sbjct: 1023 ----------------DLQIAEE------TNNPTCQGRAYGNLGLTYESLGTFERAVVYQ 1060
Query: 548 DCFLKLHAILRNSA--EVLY-QIANIYELMENPSQAIEWLMQ 586
+ L + A + + A V Y + + ++N SQA+ +L +
Sbjct: 1061 EQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQE 1102
Score = 43.5 bits (101), Expect = 8e-04
Identities = 104/541 (19%), Positives = 216/541 (39%), Gaps = 63/541 (11%)
Query: 211 NLASQYSVNEMYAEALNTYQ----VIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
NL S + Y EAL ++ + +K K A ++G++Y +Y A+ ++
Sbjct: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
Query: 267 MA-LDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYF 325
L S ++ + + N+G +I G + +A+ +E + +A +L Y
Sbjct: 339 QCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYS 398
Query: 326 AIGDREKMKKAFQKLITVP---LEIDED---KYISPSDDPHTNLVTEAIKN-DHLRQMER 378
+G ++ F K ++ LE+ ++ K I +++ + +Q
Sbjct: 399 NLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHE 458
Query: 379 ERKAMAEKYIMTSAKLIAPV---IETSFAAGYDWCVEVVKASQYV--ELANDLEINKAV- 432
++ +AE +A+ A I YD +++ K + EL++ +A
Sbjct: 459 QQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYG 518
Query: 433 ----TYLRQKDYNQAV-----EILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 483
Y Y+QAV E+ +E D +++ NL+ Y +A +
Sbjct: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
Query: 484 IAVNSDRY------NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTE------ALY 531
+N R AL+N GN + G+Y +AA +Y++ LR + +
Sbjct: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCH 638
Query: 532 NIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ------IANIYELMENPSQAIEW-- 583
N+G + L EA+ + + A+ ++ + L Q + ++ + N S+A E
Sbjct: 639 NLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQK 698
Query: 584 ----LMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYE----SYRYFPCNIEVIEW- 634
L Q ++ + L LG+++ + D + A ++Y + +++ +E +
Sbjct: 699 YLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYA 758
Query: 635 -LGAYYIDTQFWEKAIQYFERASLIQ------PTQVKWQLMVASCFRRSGNYQKALDTYK 687
LG Y Q ++KA+ Y + + P + + +A+ + G Y A Y+
Sbjct: 759 ALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYE 818
Query: 688 D 688
+
Sbjct: 819 E 819
Score = 32.3 bits (72), Expect = 1.9
Identities = 28/122 (22%), Positives = 52/122 (42%), Gaps = 2/122 (1%)
Query: 608 EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQL 667
+GD A Y E+ P N + A Y+ Q ++KA+ +A L+ P K
Sbjct: 71 DGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYF 130
Query: 668 MVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEK 727
+ G + AL + + P++++ L +V ++D+ E ++L+K
Sbjct: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE--PTYQQLQK 188
Query: 728 MK 729
MK
Sbjct: 189 MK 190
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 55.8 bits (133), Expect = 2e-07
Identities = 49/225 (21%), Positives = 94/225 (41%), Gaps = 15/225 (6%)
Query: 470 YMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEAL------RND 523
Y KDF A + D A D N +TN+ F GDY K E ++A+ R D
Sbjct: 236 YKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENRED 295
Query: 524 -SSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIE 582
+A IG +Y K + +A+ + N + ++ ++ + + + ++
Sbjct: 296 YRQIAKAYARIGNSYFKEEKYKDAIHFY--------NKSLAEHRTPDVLKKCQQAEKILK 347
Query: 583 WLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDT 642
++ + P G ++GD QA ++Y E+ + P + ++ A Y
Sbjct: 348 EQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKL 407
Query: 643 QFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 687
++ A++ E ++PT +K A+ +Y KA+D Y+
Sbjct: 408 LEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQ 452
Score = 39.3 bits (90), Expect = 0.015
Identities = 61/260 (23%), Positives = 106/260 (40%), Gaps = 22/260 (8%)
Query: 276 NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMK 334
NK+ +K + +G + + A+ Y+ + P N+ N YF GD K +
Sbjct: 221 NKKQALK-EKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCR 279
Query: 335 KAFQKLITVPLEIDED-KYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAK 393
+ +K I V E ED + I+ + I N + + E + K Y + A+
Sbjct: 280 ELCEKAIEVGRENREDYRQIAKA--------YARIGNSYFK--EEKYKDAIHFYNKSLAE 329
Query: 394 LIAPVIETSFAAGYDWCVEVVKASQYVELAN-DL---EINKAVTYLRQKDYNQAVEILKV 449
P + +++K + + N DL E NK ++ DY QA++
Sbjct: 330 HRTPDVLKKCQQAE----KILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTE 385
Query: 450 LEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDY 509
K++ + + +N +A Y +F A + + + T K + A DY
Sbjct: 386 AIKRNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDY 444
Query: 510 EKAAEFYKEALRNDSSCTEA 529
KA + Y++AL DSSC EA
Sbjct: 445 TKAMDVYQKALDLDSSCKEA 464
Score = 37.4 bits (85), Expect = 0.058
Identities = 37/154 (24%), Positives = 59/154 (38%), Gaps = 33/154 (21%)
Query: 429 NKAVTYLRQKDYNQAVEIL-KVLE-----KKDSRVKSAAATNLSALYYMGKDFAQASSYA 482
N+A Y + DYN+ E+ K +E ++D R + A + Y+ + + A +
Sbjct: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
Query: 483 DIAVNSDR-----------------------YNPAAL---TNKGNTVFANGDYEKAAEFY 516
+ ++ R NP NKGN F GDY +A + Y
Sbjct: 324 NKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHY 383
Query: 517 KEALRNDSSCTEALYNIGLTYEKLNRLDEAL-DC 549
EA++ + + N Y KL AL DC
Sbjct: 384 TEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDC 417
Score = 30.4 bits (67), Expect = 7.1
Identities = 47/221 (21%), Positives = 75/221 (33%), Gaps = 42/221 (19%)
Query: 131 PASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQ 190
P P KK+ PE + L + + ++E + N DA +K+
Sbjct: 199 PPPPPPPKKETKPEPMEEDLPENKKQALKEKELGN-------------DAYKKKDFDTAL 245
Query: 191 REQVTTPENINLDLTY-----SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILK 245
+ E ++TY +V F E+ +A+ + + +
Sbjct: 246 KHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRE--NREDYRQIAKAY 303
Query: 246 MNMGNIYLKQRNYSKAIKFYRMAL--DQVPSVNK--QMRIKIM----------------- 284
+GN Y K+ Y AI FY +L + P V K Q KI+
Sbjct: 304 ARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEE 363
Query: 285 QNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICY 324
+N G Q G Y A+ Y + P + K N CY
Sbjct: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACY 404
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/320 (22%), Positives = 121/320 (37%), Gaps = 47/320 (14%)
Query: 208 VLFNLASQYSVNEMYAEALNTYQVIVKNK-----MFSNAGILKMNMGNIYLKQRNYSKAI 262
+L+NL N +AEAL+ Y++ + ++ + N GI+ MN G +R + K
Sbjct: 529 MLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
Query: 263 KFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTI 322
+ L P +K + N+G + + G Y +A++ Y+ + P A +L
Sbjct: 589 EIPDENLKD-PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLY- 646
Query: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
M +A+ +L +P + H + + K DH+ K
Sbjct: 647 --------NMMGEAYMRLSKLP------------EAEHWYMESLRSKTDHIPAHLTYGKL 686
Query: 383 MAEKYIMTSA-KLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYN 441
+A + A KL IE ++ K + Y+ L L +
Sbjct: 687 LALTGRKSEAEKLFLKAIE----------LDPTKGNCYMHYGQFL--------LEEARLI 728
Query: 442 QAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGN 501
+A E+ K + DS + N + + A Y D+A PAAL N G
Sbjct: 729 EAAEMAKKAAELDS-TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGA 787
Query: 502 TVFANGDYEKAAEFYKEALR 521
+ NG +KA Y AL+
Sbjct: 788 ILHLNGRLQKAEANYLRALQ 807
Score = 44.7 bits (104), Expect = 4e-04
Identities = 56/254 (22%), Positives = 96/254 (37%), Gaps = 18/254 (7%)
Query: 490 RYNPA-ALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALD 548
+ NPA A N GN + + +A Y+ AL S+ + LYN+GL ++ +R EAL
Sbjct: 489 KVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALH 548
Query: 549 CFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP----TDPQV------- 597
+ KL R + Y I + + ++ S IP DP
Sbjct: 549 -YYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTS 607
Query: 598 -LSKLGELYDREGDKSQAFQYYYESYRYFPCNI---EVIEWLGAYYIDTQFWEKAIQYFE 653
L LG+LY +G +A Y E+ + P + +G Y+ +A ++
Sbjct: 608 CLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667
Query: 654 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVEC-LRFLVRLCTDLGL 712
+ + + L +G +A + P C + + L + L
Sbjct: 668 ESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARL 727
Query: 713 KDAQEYARKLKRLE 726
+A E A+K L+
Sbjct: 728 IEAAEMAKKAAELD 741
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 6/229 (2%)
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEALRN--DSSCTEALYNI-GLTYEKLNRLDEALDCF 550
+ L N G G YE+A YKEA++ ++LYN+ G Y +L++L EA +
Sbjct: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
Query: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
++ + + L S+A + ++ + + PT G+ E
Sbjct: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEAR 726
Query: 611 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 670
+A + ++ +V+ E A +Y++ A+ ++P + +
Sbjct: 727 LIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLG 786
Query: 671 SCFRRSGNYQKALDTYKDTHRKFPENV---ECLRFLVRLCTDLGLKDAQ 716
+ +G QKA Y + P++V LR L + GLK ++
Sbjct: 787 AILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSK 835
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/325 (22%), Positives = 128/325 (39%), Gaps = 59/325 (18%)
Query: 430 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGK-DFAQA--------SS 480
KA ++ DY+ + E ++ L++ L +L Y K F +A SS
Sbjct: 356 KAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSS 415
Query: 481 YADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTY--- 537
Y D+A + + AL + F DY +A + ++ AL D+ E Y +GLTY
Sbjct: 416 YPDLA---EVHALEALIH-----FTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFM 467
Query: 538 --EKLNRLDEALDCFLKLHAILRNSAEVLYQIANIY------------------ELMENP 577
E +AL FLK + +V + + Y EL +
Sbjct: 468 GEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTD 527
Query: 578 SQA----------IEWLMQVVSVIPTDPQVLS---------KLGELYDREGDKSQAFQYY 618
+++ +E + ++++ T Q S + G Y + G SQA
Sbjct: 528 AESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADL 587
Query: 619 YESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGN 678
+ R P + E LG Y+ + A++ F +AS + P + VA+ + G
Sbjct: 588 QAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGK 647
Query: 679 YQKALDTYKDTHRKFPENVECLRFL 703
Y++A+ Y+ +K + V L+ L
Sbjct: 648 YKEAVAQYQMIIKKKEDYVPALKGL 672
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/319 (23%), Positives = 127/319 (39%), Gaps = 54/319 (16%)
Query: 249 GNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIM 308
GN Y +++Y++A +Y A+D P N T + G++ +A+ + +
Sbjct: 35 GNAYYAKKDYNEAYNYYTKAIDMCPK-----NASYYGNRAATLMMLGRFREALGDAQQSV 89
Query: 309 SMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEA 367
+ + G+ C+ ++G+ ++FQ+ LE+D + + + N V
Sbjct: 90 RLDDSFVRGHLREGKCHLSLGNAMAACRSFQR----ALELDHKNAQAQQEFKNANAV--- 142
Query: 368 IKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLE 427
ME E+ A + K++ +C++ +A ++ + +
Sbjct: 143 --------MEYEKIAETDFEKRDFRKVV-------------FCMD--RALEFAPACHRFK 179
Query: 428 INKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMG------KDFAQASSY 481
I KA Y +A + + + DS A LYY + F QA
Sbjct: 180 ILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRM 239
Query: 482 A---DIAVNSDRYNPAALTNK---GNTVFANGDYEKAAEFYKEAL---RNDSSCTEALY- 531
A + A + R N AL K GN F G+Y+ A E Y EAL N+ LY
Sbjct: 240 APDHEKACIACR-NAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYC 298
Query: 532 NIGLTYEKLNRLDEAL-DC 549
N G KL +LD+A+ DC
Sbjct: 299 NRGTVNSKLRKLDDAIEDC 317
Score = 32.0 bits (71), Expect = 2.4
Identities = 24/128 (18%), Positives = 54/128 (42%)
Query: 448 KVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANG 507
++L+ ++++ ++ YY KD+ +A +Y A++ N + N+ T+ G
Sbjct: 17 ELLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLG 76
Query: 508 DYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQI 567
+ +A ++++R D S G + L A F + + +A+ +
Sbjct: 77 RFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEF 136
Query: 568 ANIYELME 575
N +ME
Sbjct: 137 KNANAVME 144
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/176 (22%), Positives = 78/176 (44%), Gaps = 20/176 (11%)
Query: 427 EINKAVTYL--RQKDYNQAVEILKVLEKKDSRVKSAAAT-----------NLSALYYMGK 473
E+++ +T R + + Q EIL L + + V + LY++ +
Sbjct: 204 ELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISE 263
Query: 474 DFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNI 533
D+A A ++ ++ P A+ KG T F G ++A E +KEAL+ +A ++
Sbjct: 264 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 323
Query: 534 GLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQAIE 582
G Y +L + A + F K + +N + +LY ++ E ++N + ++
Sbjct: 324 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ 379
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 50.8 bits (120), Expect = 5e-06
Identities = 30/122 (24%), Positives = 60/122 (49%), Gaps = 7/122 (5%)
Query: 468 LYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 527
LY++ +D+A A ++ ++ P A+ KG T F G ++A E +KEAL+
Sbjct: 205 LYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFI 264
Query: 528 EALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQA 580
+A ++G Y +L + A + F K + +N + +LY ++ E ++N +
Sbjct: 265 DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
Query: 581 IE 582
++
Sbjct: 325 LQ 326
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 8/184 (4%)
Query: 516 YKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELME 575
Y EA+R+ S+ + L +G E +N L +A+ L+ SA + +Y + E
Sbjct: 159 YDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQ--------LQPSARLYRHRGTLYFISE 210
Query: 576 NPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWL 635
+ + A E Q + + P + G + G +A + + E+ + I+ + L
Sbjct: 211 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 270
Query: 636 GAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPE 695
G Y + +E A + F++A L+ V+ + G+ Q+AL +K + P
Sbjct: 271 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
Query: 696 NVEC 699
N C
Sbjct: 331 NEVC 334
Score = 32.7 bits (73), Expect = 1.4
Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 1/138 (0%)
Query: 498 NKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAIL 557
++G F + DY A E ++++L + + A+ GLT+ L EA++ F +
Sbjct: 201 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 260
Query: 558 RNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQY 617
+ + + Y + N A E + + + Q L G + G +A +
Sbjct: 261 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 320
Query: 618 YYESYRYFPCNIEVIEWL 635
+ + P N EV +++
Sbjct: 321 FKRCLQLEPYN-EVCQYM 337
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/250 (18%), Positives = 95/250 (38%), Gaps = 1/250 (0%)
Query: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Y +Y QA I + + ++ + L+++ KD A + D+ + D+ +P
Sbjct: 515 YFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT-DMDKNSP 573
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL 553
A GN +++ A +F++ A++ D + A +G + LD+AL CF
Sbjct: 574 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 633
Query: 554 HAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 613
+ Y + IY E S A + + + P +L +G + +
Sbjct: 634 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 693
Query: 614 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 673
A ++ P N + + ++ A+Q E I P + ++ +
Sbjct: 694 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 753
Query: 674 RRSGNYQKAL 683
++ G AL
Sbjct: 754 KKLGQTHLAL 763
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 2/135 (1%)
Query: 484 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 543
I VN YN A G + + A +++AL + + L +IG+ L +
Sbjct: 634 IRVNPRHYN--AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691
Query: 544 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGE 603
++ALD K I + + A++ E A++ L ++ ++P + V +G+
Sbjct: 692 EKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGK 751
Query: 604 LYDREGDKSQAFQYY 618
+Y + G A +
Sbjct: 752 VYKKLGQTHLALMNF 766
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/250 (18%), Positives = 95/250 (38%), Gaps = 1/250 (0%)
Query: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Y +Y QA I + + ++ + L+++ KD A + D+ + D+ +P
Sbjct: 509 YFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT-DMDKNSP 567
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL 553
A GN +++ A +F++ A++ D + A +G + LD+AL CF
Sbjct: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
Query: 554 HAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 613
+ Y + IY E S A + + + P +L +G + +
Sbjct: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
Query: 614 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 673
A ++ P N + + ++ A+Q E I P + ++ +
Sbjct: 688 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 747
Query: 674 RRSGNYQKAL 683
++ G AL
Sbjct: 748 KKLGQTHLAL 757
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 2/135 (1%)
Query: 484 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 543
I VN YN A G + + A +++AL + + L +IG+ L +
Sbjct: 628 IRVNPRHYN--AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
Query: 544 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGE 603
++ALD K I + + A++ E A++ L ++ ++P + V +G+
Sbjct: 686 EKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGK 745
Query: 604 LYDREGDKSQAFQYY 618
+Y + G A +
Sbjct: 746 VYKKLGQTHLALMNF 760
>gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]
Length = 1121
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/174 (24%), Positives = 76/174 (43%), Gaps = 4/174 (2%)
Query: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
S E +A + L +N ++A E+L Q + +P V G LY G+ S+A Y
Sbjct: 928 SCEYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYE 987
Query: 620 ESYRYFPCNIE---VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRS 676
+ + E + LG Y++ + +EKA + + +A P+ + W + +C+R
Sbjct: 988 RTISFVVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWLGLGIACYRLE 1047
Query: 677 GNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKE 730
+A D + + N E +L +C +G + E A K K+K+
Sbjct: 1048 -ELTEAEDALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMIKLKLKD 1100
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/188 (21%), Positives = 73/188 (38%), Gaps = 38/188 (20%)
Query: 465 LSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANG----------------- 507
L+ + + K+FA+A Y A D NP KG+ F +G
Sbjct: 935 LAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTISFVV 994
Query: 508 --------------------DYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL 547
+YEKA + Y +A + SC L +G+ +L L EA
Sbjct: 995 DASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWL-GLGIACYRLEELTEAE 1053
Query: 548 DCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 607
D + +A+ +AEV +A + + +A + ++ + D +L+++ L +
Sbjct: 1054 DALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMIKLKLKDEALLAEIHTLQET 1113
Query: 608 EGDKSQAF 615
G + +F
Sbjct: 1114 VGFGNPSF 1121
Score = 31.2 bits (69), Expect = 4.1
Identities = 25/116 (21%), Positives = 50/116 (43%)
Query: 506 NGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLY 565
N ++E AA +YKE L + + + G +A +CF K ++ ++ L
Sbjct: 648 NENFEMAAAYYKERLVREPQNLDHWLDYGAFCLLTEDNIKAQECFQKALSLNQSHIHSLL 707
Query: 566 QIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYES 621
+ L+EN QA + + PT+ + LG Y+ + + + ++E+
Sbjct: 708 LCGVLAVLLENYEQAEIFFEDATCLEPTNVVAWTLLGLYYEIQNNDIRMEMAFHEA 763
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 45.1 bits (105), Expect = 3e-04
Identities = 62/297 (20%), Positives = 111/297 (37%), Gaps = 22/297 (7%)
Query: 429 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 484
+KA+ L +N+A +L ++ K R K A AL ASS++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DASSHSDK 1186
Query: 485 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATTISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKI 1246
Query: 541 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 597
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 598 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 654
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 655 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 711
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/436 (20%), Positives = 160/436 (36%), Gaps = 80/436 (18%)
Query: 216 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 267
Y++ Y E N TY++ + + M N+ I N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258
Query: 268 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 326
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 327 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 383
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 384 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 434
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 435 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 462
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 463 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 522
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 523 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 575
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 576 NPSQAIEWLMQVVSVI 591
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 42.7 bits (99), Expect = 0.001
Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%)
Query: 429 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 484
+KA+ L +N+A +L ++ K R K A AL A S++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186
Query: 485 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKI 1246
Query: 541 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 597
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 598 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 654
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 655 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 711
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/436 (20%), Positives = 160/436 (36%), Gaps = 80/436 (18%)
Query: 216 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 267
Y++ Y E N TY++ + + M N+ I N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258
Query: 268 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 326
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 327 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 383
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 384 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 434
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 435 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 462
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 463 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 522
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 523 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 575
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 576 NPSQAIEWLMQVVSVI 591
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 43.5 bits (101), Expect = 8e-04
Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%)
Query: 429 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 484
+KA+ L +N+A +L ++ K R K A AL A S++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186
Query: 485 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKI 1246
Query: 541 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 597
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 598 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 654
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 655 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 711
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 40.0 bits (92), Expect = 0.009
Identities = 87/436 (19%), Positives = 159/436 (36%), Gaps = 80/436 (18%)
Query: 216 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 267
Y++ Y E N TY++ + + M N+ N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGI 1258
Query: 268 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 326
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 327 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 383
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 384 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 434
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 435 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 462
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 463 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 522
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 523 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 575
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 576 NPSQAIEWLMQVVSVI 591
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
Score = 36.2 bits (82), Expect = 0.13
Identities = 64/353 (18%), Positives = 132/353 (37%), Gaps = 54/353 (15%)
Query: 318 YNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQME 377
YNL +CY G+ + K +T + +D++ Y T A+ +R+++
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY--------TAFYNRALCYTKIRELQ 1250
Query: 378 RERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQ 437
+T ++ + T E VK + + +N+ + Y+
Sbjct: 1251 ---------MALTDYGIVLLLDAT----------ETVKLNTF--------LNRGLIYVEL 1283
Query: 438 KDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALT 497
Y A+E K SR + + ++ +F +A ++ A+ + A
Sbjct: 1284 GQYGFALEDFK-QAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
Query: 498 NKGNTVFANGDYE---KAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDE-------AL 547
+GN+ G E +A + + +AL + + +A + G + + + A+
Sbjct: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
Query: 548 DCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 607
D K + A V Q+ N + M++ + A++ I T + L+ G +++
Sbjct: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK--------ISTTAEFLTNRGVIHEF 1454
Query: 608 EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP 660
G K A + Y ++ P G Y + + +A YF +A P
Sbjct: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/292 (20%), Positives = 124/292 (42%), Gaps = 21/292 (7%)
Query: 422 LANDLEINKAVTYLRQKDYNQAVEILKVLE-----KKDSRVKSAAATNLSALYYMGKDFA 476
L N+ +A+ Y Q + Q +I + K +R K A + + A M +
Sbjct: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
Query: 477 QASSYADIAVNSDRYNPAALTNKGNTVFANGD-YEKAAEFYKEALRNDSSCTEALYNIGL 535
A IA N + N N + AN E+A + Y++A+ +A + G
Sbjct: 516 GKKYAARIAPN----HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGE 571
Query: 536 TYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP--- 592
K+N+ +A + +LK + RN+A++ Y +A ++ ++ P++A++ + + + P
Sbjct: 572 LLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
Query: 593 ----TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKA 648
V+ + GE+ R + + Y E P + LG +D + +A
Sbjct: 632 LALFNSAIVMQESGEVKLRPEARKRLLSYINEE----PLDANGYFNLGMLAMDDKKDNEA 687
Query: 649 IQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 700
+ ++A +Q +A + ++ KAL ++ R +P++++ L
Sbjct: 688 EIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGL 739
Score = 44.7 bits (104), Expect = 4e-04
Identities = 40/191 (20%), Positives = 81/191 (42%), Gaps = 15/191 (7%)
Query: 485 AVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLD 544
A+ ++ N N G+ + ++E+A +++ +A A N+G TY+ LNR
Sbjct: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
Query: 545 EALDCFLKLHAIL--------------RNSAEVLYQIANIYELMENP-SQAIEWLMQVVS 589
EA + ++ +++ N V +AN+ E+ +A + Q +S
Sbjct: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAIS 557
Query: 590 VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAI 649
+ P Q GEL + +A + Y ++ N ++ L +I+ + +A+
Sbjct: 558 MRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEAL 617
Query: 650 QYFERASLIQP 660
+ F RA + P
Sbjct: 618 KNFNRALELNP 628
Score = 32.3 bits (72), Expect = 1.9
Identities = 21/97 (21%), Positives = 39/97 (40%)
Query: 496 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHA 555
LT+ T N D+E + AL+ + + + N+G E + AL FL+
Sbjct: 415 LTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATH 474
Query: 556 ILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592
+ + + Y+ + +A E M S++P
Sbjct: 475 VQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMP 511
Score = 32.3 bits (72), Expect = 1.9
Identities = 74/397 (18%), Positives = 148/397 (37%), Gaps = 40/397 (10%)
Query: 236 KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAG 295
K+ N L N+G+ ++N+ +A+K++ A P I N+G T+
Sbjct: 440 KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPD-----DIGAHMNVGRTYKNLN 494
Query: 296 QYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISP 355
+ +A SY S+ P + G KK ++ L + YI+
Sbjct: 495 RTKEAEESYMMAKSLMPQIIPG----------------KKYAARIAPNHLNV----YINL 534
Query: 356 SDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVK 415
++ N + RQ R + YI L+ Y +K
Sbjct: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY------LK 588
Query: 416 ASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMG--K 473
A + DL N A+ ++ K+ N+A++ + + + K A + + G K
Sbjct: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648
Query: 474 DFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNI 533
+A +N + + N G + +A + K+A++ + AL+N+
Sbjct: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
Query: 534 GLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI----EWLMQVVS 589
L Y + + +AL L +LR + + + +++ N + I + +++
Sbjct: 709 ALLYSQTAKELKALPI---LEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILE 765
Query: 590 VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFP 626
+ P++ Q L +Y E D +A + E+ P
Sbjct: 766 MDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 232 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 290
Query: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
Query: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
+ N ++ LG Q ++ + FERA
Sbjct: 351 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 386
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 533 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 231 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
Query: 593 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
Query: 653 ER 654
R
Sbjct: 350 RR 351
Score = 37.0 bits (84), Expect = 0.076
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 350
Query: 267 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 322
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 351 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 405
Query: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
IGD + F+ + + N EA N + +M +
Sbjct: 406 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 448
Query: 383 MAEKYIMTSAKLIAPVIETSF 403
A + T++ L + E F
Sbjct: 449 QARALLQTASSLAPHMYEPHF 469
Score = 34.7 bits (78), Expect = 0.38
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 302 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 360
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
Query: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
Query: 611 KSQAFQYYYESYRYFPCNIE 630
+++ +S FP +++
Sbjct: 481 LQRSYVAAQKSEAAFPDHVD 500
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 192 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 250
Query: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 251 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 310
Query: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
+ N ++ LG Q ++ + FERA
Sbjct: 311 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 346
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 533 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 191 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 249
Query: 593 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 250 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 309
Query: 653 ER 654
R
Sbjct: 310 RR 311
Score = 37.0 bits (84), Expect = 0.076
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 253 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 310
Query: 267 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 322
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 311 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 365
Query: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
IGD + F+ + + N EA N + +M +
Sbjct: 366 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 408
Query: 383 MAEKYIMTSAKLIAPVIETSF 403
A + T++ L + E F
Sbjct: 409 QARALLQTASSLAPHMYEPHF 429
Score = 34.7 bits (78), Expect = 0.38
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 262 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 320
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 321 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 380
Query: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 381 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 440
Query: 611 KSQAFQYYYESYRYFPCNIE 630
+++ +S FP +++
Sbjct: 441 LQRSYVAAQKSEAAFPDHVD 460
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 559
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 222 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 280
Query: 560 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 619
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
Query: 620 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
+ N ++ LG Q ++ + FERA
Sbjct: 341 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 376
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 533 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 592
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 221 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
Query: 593 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
Query: 653 ER 654
R
Sbjct: 340 RR 341
Score = 37.0 bits (84), Expect = 0.076
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 266
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 340
Query: 267 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 322
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 341 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 395
Query: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
IGD + F+ + + N EA N + +M +
Sbjct: 396 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 438
Query: 383 MAEKYIMTSAKLIAPVIETSF 403
A + T++ L + E F
Sbjct: 439 QARALLQTASSLAPHMYEPHF 459
Score = 34.7 bits (78), Expect = 0.38
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 292 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 350
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
Query: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
Query: 611 KSQAFQYYYESYRYFPCNIE 630
+++ +S FP +++
Sbjct: 471 LQRSYVAAQKSEAAFPDHVD 490
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 15/125 (12%)
Query: 495 ALTNKGNTVFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALD 548
A +N GN G++E A+E+YK+ L++ + ++ Y++G TY L ++A+D
Sbjct: 244 AYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAID 303
Query: 549 CFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 602
LK AI + + + N Y + N QA+ + + + + +V K G
Sbjct: 304 YHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI---SREVGDKSG 360
Query: 603 ELYDR 607
EL R
Sbjct: 361 ELTAR 365
Score = 33.9 bits (76), Expect = 0.64
Identities = 62/297 (20%), Positives = 113/297 (38%), Gaps = 39/297 (13%)
Query: 248 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 306
+GN Y +Y+KA++++ L ++ Q+ K N+G T G + +AI +
Sbjct: 68 LGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQR 127
Query: 307 IMSMAPNL-------KAGYNLTICYFAIGDREKMKKAF-----QKLITVPLEIDEDKYIS 354
+ ++ L +A YNL Y A G K+F Q + P E+ D +
Sbjct: 128 HLDISRELNDKVGEARALYNLGNVYHAKG------KSFGCPGPQDVGEFPEEV-RDALQA 180
Query: 355 PSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVV 414
D NL D Q Y++ + + E ++ +
Sbjct: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
Query: 415 KASQYVELANDLEINKAVTYLRQKDYNQAVE-----ILKVLEKKDSRVKSAAATNLSALY 469
+ Y L N Y+ ++ A E +L + KD V++ + +L Y
Sbjct: 241 ERRAYSNLGN--------AYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTY 292
Query: 470 YMGKDFAQASSY-----ADIAVNSDRYNPA-ALTNKGNTVFANGDYEKAAEFYKEAL 520
+ +D+ +A Y A +DR A + GN A G++++A F ++ L
Sbjct: 293 TLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349
Score = 32.7 bits (73), Expect = 1.4
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 12/90 (13%)
Query: 494 AALTNKGNTVFANGDYEKAAEFYKEALR------NDSSCTEALYNIGLTYEKLNRLDEAL 547
A + GN F DY KA E++ L + +A N+G T + L DEA+
Sbjct: 63 AIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAI 122
Query: 548 DCFLKLHAILR------NSAEVLYQIANIY 571
C + I R A LY + N+Y
Sbjct: 123 VCCQRHLDISRELNDKVGEARALYNLGNVY 152
>gi|6912398 general transcription factor IIIC, polypeptide 3, 102kDa
[Homo sapiens]
Length = 886
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/120 (22%), Positives = 57/120 (47%)
Query: 568 ANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPC 627
ANI +AI M+++ P + S L +Y+ +GD ++ Q+ + P
Sbjct: 156 ANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPS 215
Query: 628 NIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 687
+ E L ++ ++AI + +A +PT V++ +S + + G+++ A+D Y+
Sbjct: 216 DTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYR 275
Score = 39.7 bits (91), Expect = 0.012
Identities = 29/123 (23%), Positives = 52/123 (42%)
Query: 496 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHA 555
L + N FA G+ E+A E +R E + + YE ++++L L
Sbjct: 152 LMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAH 211
Query: 556 ILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAF 615
+ + E ++A + +N QAI + + PT+ + L + LY++ GD A
Sbjct: 212 LNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAM 271
Query: 616 QYY 618
Y
Sbjct: 272 DGY 274
Score = 35.0 bits (79), Expect = 0.29
Identities = 29/151 (19%), Positives = 69/151 (45%), Gaps = 7/151 (4%)
Query: 507 GDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 566
GD EK+ +F A + S TE + + + + +A+ C+ K + L++
Sbjct: 197 GDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWE 256
Query: 567 IANIYELMENPSQAIEWLMQVVSVI-PTD----PQVLSKLGELYDREGDKSQAFQYYYES 621
+++YE M + A++ ++++++ P+D Q+ + + Y D + A E+
Sbjct: 257 RSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEA 316
Query: 622 YRYFP--CNIEVIEWLGAYYIDTQFWEKAIQ 650
+ ++E + YI + ++KA++
Sbjct: 317 FSKHQGLVSMEDVNIAAELYISNKQYDKALE 347
>gi|6912630 interferon-induced protein with tetratricopeptide
repeats 5 [Homo sapiens]
Length = 482
Score = 41.2 bits (95), Expect = 0.004
Identities = 79/347 (22%), Positives = 139/347 (40%), Gaps = 41/347 (11%)
Query: 297 YSDAINSYEHIMSMAPN---LKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYI 353
Y A ++E + + P+ GY +T+ DRE K+F PL K +
Sbjct: 156 YQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFS---LGPLR----KAV 208
Query: 354 SPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIA--PVIETSFAAGYDWCV 411
+ + D V A+K L+ + E A EKYI I+ P + A Y
Sbjct: 209 TLNPDNSYIKVFLALK---LQDVHAE--AEGEKYIEEILDQISSQPYVLRYAAKFYRRKN 263
Query: 412 EVVKASQYVELANDLEINKAVTYLR-QKDYNQAVEILKVLEKKDSRVKSAAATNLSALYY 470
KA + ++ A LE+ ++L Q +++++ + +R K + L
Sbjct: 264 SWNKALELLKKA--LEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDEL-- 319
Query: 471 MGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEAL 530
+ A + A+ D A T+ N G Y A + +++ALR ++ +
Sbjct: 320 ----ISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHK 375
Query: 531 YNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLY----QIANIYELMENPSQAIEWLM- 585
+ I Y + F + H N+A Y ++ + L + A++ L
Sbjct: 376 HQIHYHYGR----------FQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLST 425
Query: 586 QVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVI 632
+ + D Q LS LG +Y EG+K QA +YY ++ + P N E +
Sbjct: 426 KRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFL 472
>gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Homo
sapiens]
Length = 864
Score = 40.4 bits (93), Expect = 0.007
Identities = 56/288 (19%), Positives = 117/288 (40%), Gaps = 37/288 (12%)
Query: 470 YMGKDFAQASSYADIAVNSDRY--NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 527
Y K + + + +++ ++ + L KG T+ G E+A EF ++ LRND
Sbjct: 21 YEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSH 80
Query: 528 EALYNIGLTYEKLNRLDEALDCF---LKLH----AILRNSAEVLYQIANI-------YEL 573
+ GL + DEA+ C+ LKL ILR+ + + Q+ ++ Y+L
Sbjct: 81 VCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQL 140
Query: 574 ME-NPSQAIEWLMQVVS--VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIE 630
++ P+Q W+ ++ ++ L L E + Y Y E
Sbjct: 141 LQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYS---------E 191
Query: 631 VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTH 690
+I + + ++++++ E ++ + + + G ++A + +K+
Sbjct: 192 LILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI 251
Query: 691 RKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKS 738
+ EN C GL+ A + + +RL+ +EI +Q K+
Sbjct: 252 DRNAEN---------WCYYEGLEKALQISTLEERLQIYEEISKQHPKA 290
Score = 30.4 bits (67), Expect = 7.1
Identities = 67/325 (20%), Positives = 128/325 (39%), Gaps = 34/325 (10%)
Query: 428 INKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALY-YMGKDFAQASSYADIAV 486
I A+ Y KDY+ A+++L+ + + S L Y + +A +
Sbjct: 152 IGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREADLLQESLE 211
Query: 487 NSDRYNPAALTN------KGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE-K 539
+ + Y KG + G ++A+E +K + D + Y GL +
Sbjct: 212 HIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI--DRNAENWCYYEGLEKALQ 269
Query: 540 LNRLDEALDCFLKLH-----AIL-RNSAEVLYQIANIYELME-----NPSQAIEWLMQVV 588
++ L+E L + ++ AI R L ELM+ N S+ L +
Sbjct: 270 ISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTL 329
Query: 589 SVIPTDPQVLSKLGEL---YDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQF- 644
+ + + +S + EL Y+ F Y + P + +++ A + D
Sbjct: 330 KSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPPTTLLWVQYFLAQHFDKLGQ 389
Query: 645 WEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKA---LDTYK--DTHRKFPENVEC 699
+ A+ Y A PT ++ M A ++ GN ++A +D + DT +F N +C
Sbjct: 390 YSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDEAQSLDTADRF-INSKC 448
Query: 700 LRFLVRLCTDLGLKDAQEYARKLKR 724
++++R +K+A+E K R
Sbjct: 449 AKYMLRANM---IKEAEEMCSKFTR 470
>gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [Homo
sapiens]
Length = 429
Score = 40.4 bits (93), Expect = 0.007
Identities = 56/288 (19%), Positives = 117/288 (40%), Gaps = 37/288 (12%)
Query: 470 YMGKDFAQASSYADIAVNSDRY--NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 527
Y K + + + +++ ++ + L KG T+ G E+A EF ++ LRND
Sbjct: 21 YEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSH 80
Query: 528 EALYNIGLTYEKLNRLDEALDCF---LKLH----AILRNSAEVLYQIANI-------YEL 573
+ GL + DEA+ C+ LKL ILR+ + + Q+ ++ Y+L
Sbjct: 81 VCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQL 140
Query: 574 ME-NPSQAIEWLMQVVS--VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIE 630
++ P+Q W+ ++ ++ L L E + Y Y E
Sbjct: 141 LQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYS---------E 191
Query: 631 VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTH 690
+I + + ++++++ E ++ + + + G ++A + +K+
Sbjct: 192 LILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI 251
Query: 691 RKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKS 738
+ EN C GL+ A + + +RL+ +EI +Q K+
Sbjct: 252 DRNAEN---------WCYYEGLEKALQISTLEERLQIYEEISKQHPKA 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,599,106
Number of Sequences: 37866
Number of extensions: 1215605
Number of successful extensions: 6676
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 6043
Number of HSP's gapped (non-prelim): 579
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.