Search of human proteins with 28416953

Search of human proteins with 28416953

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28416953 acyl-CoA synthetase short-chain family member 1
[Homo sapiens]
         (689 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom...  1403   0.0  
gi|8923896 acyl-CoA synthetase short-chain family member 2 isofo...   613   e-175
gi|253970489 acyl-CoA synthetase short-chain family member 2 iso...   608   e-174
gi|13375727 acyl-CoA synthetase short-chain family member 3 [Hom...   371   e-102
gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H...   187   2e-47
gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H...   177   4e-44
gi|42544132 SA hypertension-associated homolog isoform 1 [Homo s...   174   3e-43
gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]                 172   7e-43
gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Ho...   169   1e-41
gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H...   162   1e-39
gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   155   1e-37
gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   155   1e-37
gi|157311624 acyl-CoA synthetase medium-chain family member 2B [...   151   2e-36
gi|157311622 acyl-CoA synthetase medium-chain family member 2B [...   151   2e-36
gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]       124   4e-28
gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]        98   3e-20
gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]        98   3e-20
gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Ho...    91   3e-18
gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s...    88   2e-17
gi|38524616 solute carrier family 27, member 1 [Homo sapiens]          78   3e-14
gi|40807357 solute carrier family 27 (fatty acid transporter), m...    69   1e-11
gi|62865631 solute carrier family 27 (fatty acid transporter), m...    69   1e-11
gi|13325055 solute carrier family 27 (fatty acid transporter), m...    69   1e-11
gi|13236579 solute carrier family 27 member 3 [Homo sapiens]           48   3e-05
gi|13325057 solute carrier family 27 (fatty acid transporter), m...    46   1e-04
gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens]     44   7e-04
gi|227499619 solute carrier family 27 (fatty acid transporter), ...    43   9e-04
gi|4758332 acyl-CoA synthetase long-chain family member 4 isofor...    40   0.006
gi|12669909 acyl-CoA synthetase long-chain family member 4 isofo...    40   0.006
gi|24497589 aristaless related homeobox [Homo sapiens]                 38   0.027

>gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo
           sapiens]
          Length = 689

 Score = 1403 bits (3632), Expect = 0.0
 Identities = 689/689 (100%), Positives = 689/689 (100%)

Query: 1   MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA 60
           MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
Sbjct: 1   MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA 60

Query: 61  LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR 120
           LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
Sbjct: 61  LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR 120

Query: 121 KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA 180
           KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
Sbjct: 121 KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA 180

Query: 181 AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK 240
           AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
Sbjct: 181 AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK 240

Query: 241 HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM 300
           HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
Sbjct: 241 HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM 300

Query: 301 PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF 360
           PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
Sbjct: 301 PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF 360

Query: 361 ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420
           ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
Sbjct: 361 ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420

Query: 421 NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL 480
           NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
Sbjct: 421 NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL 480

Query: 481 MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG 540
           MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
Sbjct: 481 MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG 540

Query: 541 GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD 600
           GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
Sbjct: 541 GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD 600

Query: 601 SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG 660
           SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
Sbjct: 601 SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG 660

Query: 661 DTTTLEDPSIIAEILSVYQKCKDKQAAAK 689
           DTTTLEDPSIIAEILSVYQKCKDKQAAAK
Sbjct: 661 DTTTLEDPSIIAEILSVYQKCKDKQAAAK 689


>gi|8923896 acyl-CoA synthetase short-chain family member 2 isoform
           1 [Homo sapiens]
          Length = 701

 Score =  613 bits (1581), Expect = e-175
 Identities = 320/696 (45%), Positives = 429/696 (61%), Gaps = 45/696 (6%)

Query: 17  LRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPG--SYPALSAQAAREPAAFWG 74
           +R  SG   +   G     R+ S P    P V+ +A  P    Y  L  ++  EP  FWG
Sbjct: 8   VRSGSGSRGQEEAGAGGRARSWSPP----PEVSRSAHVPSLQRYRELHRRSVEEPREFWG 63

Query: 75  PLARDTLVWDTPY---HTVWDCDFSTGKI--GWFLGGQLNVSVNCLDQ--HVRKSPESVA 127
            +A++   W TP       ++ D + GKI   W  G   N+  N LD+  H +K  + VA
Sbjct: 64  DIAKE-FYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVA 122

Query: 128 LIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACAR 187
             WE +EPG   +ITY +LL   C+ +N L++ G+ +GDRVAIYMP+ P  V AMLACAR
Sbjct: 123 FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACAR 182

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHC----- 242
           IGA+H+++FAGFS+ESL  RI D+ C ++IT +   RG ++V LK++ DEA++ C     
Sbjct: 183 IGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGF 242

Query: 243 PTVQHVLVAHRTDNKVHMGD----------------------LDVPLEQEMAKEDPVCAP 280
           P    ++V H    ++ MGD                      +D+   + M +    C P
Sbjct: 243 PVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEP 302

Query: 281 ESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWI 340
           E   +ED LF+LYTSGSTG PKG+VHT  GY+LY A T K VFD    D+F C ADIGWI
Sbjct: 303 EWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWI 362

Query: 341 TGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDA 400
           TGHSYV YGPL NGATSVLFE  P YP+  R W  V++ K+ +FY APTA+RLL+K+GD 
Sbjct: 363 TGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDE 422

Query: 401 WVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEE 460
            V K+ R+SL+ LG+VGEPIN EAW W HRVVG  RC +VDT+WQTETGG  + P P   
Sbjct: 423 PVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG-- 480

Query: 461 GAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDA 520
              + P  A  PFFG+ P +++E G  +EG    G L   Q WPG+ RT+YG+H+RF   
Sbjct: 481 ATPMKPGSATFPFFGVAPAILNESGEELEG-EAEGYLVFKQPWPGIMRTVYGNHERFETT 539

Query: 521 YFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580
           YFK +PGYY TGDG  R + GYY ITGR+DD++N+SGH L TAE+E A+ +H AV E+AV
Sbjct: 540 YFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAV 599

Query: 581 IGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRS 640
           +G+PH +KGE  + F+ + D    S  + +ELK  +  KI   A PD I     LPKTRS
Sbjct: 600 VGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRS 659

Query: 641 GKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILS 676
           GK+MRR+LRKI  ++  +LGD +T+ DPS+I+ + S
Sbjct: 660 GKIMRRVLRKIAQND-HDLGDMSTVADPSVISHLFS 694


>gi|253970489 acyl-CoA synthetase short-chain family member 2
           isoform 2 [Homo sapiens]
          Length = 714

 Score =  608 bits (1568), Expect = e-174
 Identities = 320/709 (45%), Positives = 429/709 (60%), Gaps = 58/709 (8%)

Query: 17  LRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPG--SYPALSAQAAREPAAFWG 74
           +R  SG   +   G     R+ S P    P V+ +A  P    Y  L  ++  EP  FWG
Sbjct: 8   VRSGSGSRGQEEAGAGGRARSWSPP----PEVSRSAHVPSLQRYRELHRRSVEEPREFWG 63

Query: 75  PLARDTLVWDTPY---HTVWDCDFSTGKI--GWFLGGQLNVSVNCLDQ--HVRKSPESVA 127
            +A++   W TP       ++ D + GKI   W  G   N+  N LD+  H +K  + VA
Sbjct: 64  DIAKE-FYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVA 122

Query: 128 LIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACAR 187
             WE +EPG   +ITY +LL   C+ +N L++ G+ +GDRVAIYMP+ P  V AMLACAR
Sbjct: 123 FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACAR 182

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHC----- 242
           IGA+H+++FAGFS+ESL  RI D+ C ++IT +   RG ++V LK++ DEA++ C     
Sbjct: 183 IGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGF 242

Query: 243 PTVQHVLVAHRTDNKVHMGD-----------------------------------LDVPL 267
           P    ++V H    ++ MGD                                   +D+  
Sbjct: 243 PVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQGKLKEKSKRVQPQISWNQGIDLWW 302

Query: 268 EQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQP 327
            + M +    C PE   +ED LF+LYTSGSTG PKG+VHT  GY+LY A T K VFD   
Sbjct: 303 HELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHA 362

Query: 328 GDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGA 387
            D+F C ADIGWITGHSYV YGPL NGATSVLFE  P YP+  R W  V++ K+ +FY A
Sbjct: 363 EDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTA 422

Query: 388 PTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTE 447
           PTA+RLL+K+GD  V K+ R+SL+ LG+VGEPIN EAW W HRVVG  RC +VDT+WQTE
Sbjct: 423 PTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTE 482

Query: 448 TGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMA 507
           TGG  + P P      + P  A  PFFG+ P +++E G  +EG    G L   Q WPG+ 
Sbjct: 483 TGGHMLTPLPG--ATPMKPGSATFPFFGVAPAILNESGEELEG-EAEGYLVFKQPWPGIM 539

Query: 508 RTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIED 567
           RT+YG+H+RF   YFK +PGYY TGDG  R + GYY ITGR+DD++N+SGH L TAE+E 
Sbjct: 540 RTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVES 599

Query: 568 AIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPD 627
           A+ +H AV E+AV+G+PH +KGE  + F+ + D    S  + +ELK  +  KI   A PD
Sbjct: 600 ALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPD 659

Query: 628 EILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILS 676
            I     LPKTRSGK+MRR+LRKI  ++  +LGD +T+ DPS+I+ + S
Sbjct: 660 YIQNAPGLPKTRSGKIMRRVLRKIAQND-HDLGDMSTVADPSVISHLFS 707


>gi|13375727 acyl-CoA synthetase short-chain family member 3 [Homo
           sapiens]
          Length = 686

 Score =  371 bits (953), Expect = e-102
 Identities = 236/684 (34%), Positives = 361/684 (52%), Gaps = 39/684 (5%)

Query: 11  GRLLGSLRGLSGQPARPPCGVSAPRRA--ASGPSGSAPAVAAAAAQPGS---YPALSAQA 65
           G L G L G S  PAR   G  A  RA    GP G        A   GS   Y    A +
Sbjct: 15  GGLGGPLPGSS--PAR---GAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAAS 69

Query: 66  AREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSP-E 124
             +P  FWG  A + + W  P+    +   S     WF+ G LN+  N +D+H+     +
Sbjct: 70  VTDPERFWGKAA-EQISWYKPWTKTLENKHSPST-RWFVEGMLNICYNAVDRHIENGKGD 127

Query: 125 SVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLA 184
            +A+I++     T+   TY+E+LE   +LA  L +HG+ +GD V IYMP+ P A+  MLA
Sbjct: 128 KIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLA 187

Query: 185 CARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK---H 241
           CARIGA+H++IF GF+++ L+ RI+  K KVV+T + G+  GR VE   +V+EA+K   H
Sbjct: 188 CARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQH 247

Query: 242 CPTVQHVLVAHRTDNKV--HMGDLDVPLEQEMAK-EDPVCAPESMGSEDMLFMLYTSGST 298
            P    +L+ +R + +        D+  ++EMAK +   C P  + SE  L++LYTSG+T
Sbjct: 248 KP--DKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVP--VLSEHPLYILYTSGTT 303

Query: 299 GMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSV 358
           G+PKG++    GY +    +   ++  QPG+++   +D+GW+ GHSY+ YGPL +G T+V
Sbjct: 304 GLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTV 363

Query: 359 LFESTPV-YPNAGRYWETVERLKINQFYGAPTAVRLLLKY--GDAWVKKYDRSSLRTLGS 415
           L+E  PV  P+AG Y+  +    +   + APTA+R + +   G A  K+Y  +  +TL  
Sbjct: 364 LYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFV 423

Query: 416 VGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETG----GICIAPRPSEEGAEILPAMAMR 471
            GE  + E  EW   V    R  ++D WWQTETG      C+    S+      P  A +
Sbjct: 424 AGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTPP---PGQAGK 477

Query: 472 PFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFT 531
              G   +++D+    ++   +   +      PG    ++ + + F   YF+ +PGYY T
Sbjct: 478 SVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDT 537

Query: 532 GDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEA 591
            D  Y  E GY  +  R+DDVIN++GHR+    IE++I  H  V + AV+G    +KG  
Sbjct: 538 MDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHV 597

Query: 592 AFAFIVV-KDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRK 650
             A  V+ KD     + V++E+   V   I   A     + VK+LPKTRSGK+ R  L  
Sbjct: 598 PLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSA 657

Query: 651 IITSEAQELGDTTTLEDPSIIAEI 674
           I+  +  ++  T+T+EDPSI   +
Sbjct: 658 IVNGKPYKI--TSTIEDPSIFGHV 679


>gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo
           sapiens]
          Length = 580

 Score =  187 bits (476), Expect = 2e-47
 Identities = 160/551 (29%), Positives = 257/551 (46%), Gaps = 40/551 (7%)

Query: 109 NVSVNCLDQHVRKS-----PESVALIWERDEPGTEVRITYRELLETTCRLANTL-KRHGV 162
           N + + LDQ  +K      P + AL W   + G EV+ ++REL   + + AN L K  G+
Sbjct: 53  NFAADVLDQWSQKEKTGERPANPALWWVNGK-GDEVKWSFRELGSLSRKAANVLTKPCGL 111

Query: 163 HRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQG 222
            RGDR+A+ +P  P      +AC R G +        +A+ +  R+  +K K ++     
Sbjct: 112 QRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE-- 169

Query: 223 LRGGRVVELKKIVDEAVKHCPTVQ-HVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPE 281
                  E+   V+  V  CP ++  +LV+ ++ N    G L      + A E+  C   
Sbjct: 170 -------EVAPAVESIVLECPDLKTKLLVSPQSWN----GWLSFQELFQFASEEHSCV-- 216

Query: 282 SMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWIT 341
             GS++ + + +TSG+TG PK   H+Q+   +   L  +   D +  DI   ++D GW+ 
Sbjct: 217 ETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVK 276

Query: 342 GHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAW 401
                V+     GA   +F       +   + +T+    I      PT  R+L++     
Sbjct: 277 AAIGSVFSSWLCGAC--VFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKD--- 331

Query: 402 VKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEG 461
           +K+Y   SLR   + GEP+N E  E      G     L + + QTE G IC     +++G
Sbjct: 332 LKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTG---LELYEGYGQTEVGMICA----NQKG 384

Query: 462 AEILPAMAMRPFFGIVPVLMDEKGSVVE-GSNVSGALCISQAWPGMARTIYGDHQRFVDA 520
            EI P    +        ++DE G+V+  G     AL +    P    + Y D+ +   A
Sbjct: 385 QEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAA 444

Query: 521 YFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580
             +    +Y TGD       GY+   GR DDVI  SG+R+G  E+E A+ +HPAV ESAV
Sbjct: 445 TIRG--DFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAV 502

Query: 581 IGYPHDIKGEAAFAFIVVKD--SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKT 638
           +  P  I+GE   AF+V+     + + + +  EL+  V    A Y  P ++  V+ LPKT
Sbjct: 503 VSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKT 562

Query: 639 RSGKVMRRLLR 649
            +GK+ R +LR
Sbjct: 563 ITGKIKRNVLR 573


>gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo
           sapiens]
          Length = 577

 Score =  177 bits (448), Expect = 4e-44
 Identities = 154/557 (27%), Positives = 255/557 (45%), Gaps = 36/557 (6%)

Query: 107 QLNVSVNCLDQHVRKSPESVA----LIWERDEPGTEVRITYRELLETTCRLANTLKRH-G 161
           + N +   LD   +K  E         W  +  G EV+ ++RE+ + T R+AN   +  G
Sbjct: 48  EFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCG 107

Query: 162 VHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQ 221
           + +GD +A+ +P  P      + C R G +         A+ +  R+  +K K ++T + 
Sbjct: 108 LQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDA 167

Query: 222 GLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPE 281
                    L   VD     CP+++  L+      +   G LD     + A  +  C   
Sbjct: 168 ---------LASEVDSIASQCPSLKTKLLVSDHSRE---GWLDFRSLVKSASPEHTCVKS 215

Query: 282 SMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWIT 341
              + D + + +TSG+TG PK   H+    L  +    + +   +  D+  C++D GWI 
Sbjct: 216 K--TLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIV 273

Query: 342 GHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAW 401
              + +  P   G T V     P + +     +T+ +  IN F+G  +  R++L+     
Sbjct: 274 ATIWTLVEPWTAGCT-VFIHHLPQF-DTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTS 331

Query: 402 VKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEG 461
           ++        T G V  P + E W+   R  G     L + + Q+ETG IC     +  G
Sbjct: 332 IRFPALEHCYTGGEVVLPKDQEEWK---RRTG---LLLYENYGQSETGLICA----TYWG 381

Query: 462 AEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAY 521
            +I P    +        ++D+KGS++   N  G + I +  P    +++  ++   +  
Sbjct: 382 MKIKPGFMGKATPPYDVQVIDDKGSILP-PNTEGNIGI-RIKPVRPVSLFMCYEGDPEKT 439

Query: 522 FKAYPG-YYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580
            K   G +Y TGD     E GY    GR DD+IN SG+R+G AE+E A+ +HPAV ESAV
Sbjct: 440 AKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAV 499

Query: 581 IGYPHDIKGEAAFAFIVVKDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKT 638
           +G P  I+GE   AFIV+     + D D + +EL+  V +  A Y  P ++  V  LPKT
Sbjct: 500 VGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKT 559

Query: 639 RSGKVMRRLLRKIITSE 655
            +GK+ R+ LRK  T +
Sbjct: 560 ITGKIERKELRKKETGQ 576


>gi|42544132 SA hypertension-associated homolog isoform 1 [Homo
           sapiens]
          Length = 586

 Score =  174 bits (440), Expect = 3e-43
 Identities = 153/567 (26%), Positives = 251/567 (44%), Gaps = 45/567 (7%)

Query: 94  DFSTGKIGWFLGGQLNVSVNCLDQ-----HVRKSPESVALIWERDEPGTEVRITYRELLE 148
           DF  G   +F     N + + LDQ        K P + A  W  +  G E+R ++ EL  
Sbjct: 49  DFKLGIPEYF-----NFAKDVLDQWTDKEKAGKKPSNPAFWWI-NRNGEEMRWSFEELGS 102

Query: 149 TTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGR 207
            + + AN L     + RGDRV + +P  P    A +AC R G V        + + +  R
Sbjct: 103 LSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYR 162

Query: 208 INDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPL 267
           +  +K   +IT +          L   VD     C  +   L+    +++   G+L   +
Sbjct: 163 LQSSKANCIITNDV---------LAPAVDAVASKCENLHSKLIVSE-NSREGWGNLKELM 212

Query: 268 EQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQP 327
           +   A +   C        +++ + +TSG++G PK   HT + + L  ++  +   D  P
Sbjct: 213 KH--ASDSHTCVKTK--HNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTP 268

Query: 328 GDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGA 387
            D+    +D GW       V+ P   GA           P +    +T+ +  I  F  A
Sbjct: 269 SDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTS--ILQTLSKYPITVFCSA 326

Query: 388 PTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWE-WLHRVVGDSRCTLVDTWWQT 446
           PT  R+L++     +  Y   SL+   S GEPI  +  E W ++   D    + + + QT
Sbjct: 327 PTVYRMLVQND---ITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLD----IYEGYGQT 379

Query: 447 ETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVE-GSNVSGALCISQAWPG 505
           ET  IC     + +G +I P    +P       ++D  G+V+  G      + +    P 
Sbjct: 380 ETVLIC----GNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPF 435

Query: 506 MARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEI 565
              T Y D+     +  +    +Y TGD  Y  + GY+    R DDVI  SG+R+G  E+
Sbjct: 436 GLFTHYVDNPSKTASTLRG--NFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEV 493

Query: 566 EDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD--SAGDSDVVVQELKSMVATKIAKY 623
           E+A+ +HP+V ESAV+  P  I+GE   AF+V+     + D + +++E++  V    A Y
Sbjct: 494 ENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPY 553

Query: 624 AVPDEILVVKRLPKTRSGKVMRRLLRK 650
             P ++  ++ LPKT SGK  R  LRK
Sbjct: 554 KYPRKVEFIQELPKTISGKTKRNELRK 580


>gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]
          Length = 672

 Score =  172 bits (437), Expect = 7e-43
 Identities = 150/627 (23%), Positives = 269/627 (42%), Gaps = 28/627 (4%)

Query: 49  AAAAAQPGSYPALSAQAAREPAAFWGPLARDT-LVWDTPYHTVWDCDFSTGKIG-WFLGG 106
           AA      SY  L   +    + FW    + + +V+   Y  V D       +  WF G 
Sbjct: 38  AACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGS 97

Query: 107 QLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGD 166
           +LN + N L     K  + VAL   R+     V++T+ EL +     A  +++ GV +GD
Sbjct: 98  RLNYAENLLRH---KENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGD 154

Query: 167 RVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGG 226
           RV  Y+P S  AV AMLA A IGA+ +     F    +  R +  + K++ +    +  G
Sbjct: 155 RVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNG 214

Query: 227 RVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVP--------LEQEMAKEDPVC 278
           +     + + + VK  P ++ V+V     ++ ++    +P        L    +++ P  
Sbjct: 215 KEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQL 274

Query: 279 APESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIG 338
             E +     LF++++SG+TG PK +VH+  G L+     H L  +    DI  C   +G
Sbjct: 275 EFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVG 334

Query: 339 WITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYG 398
           W+  +  V    L  GA  VL++ +P+ P     W+ V+R+ I         + +L +  
Sbjct: 335 WMMWNWMVSL--LATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKA 392

Query: 399 DAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAP--R 456
              V+ +    L T+ S G P+  +++E+++R +  S          + +GG  I     
Sbjct: 393 MKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILL------GSISGGTDIISCFM 446

Query: 457 PSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQ- 515
                  +          G+     +E+G  V G   SG L  ++  P      + D   
Sbjct: 447 GHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGE--SGELVCTKPIPCQPTHFWNDENG 504

Query: 516 -RFVDAYFKAYPGYYFTGDGA-YRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHP 573
            ++  AYF  +PG +  GD      + G   + GR D  +N +G R G++EI + +    
Sbjct: 505 NKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFE 564

Query: 574 AVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVK 633
            V +S  +   +  + E    F+ +         +V+ ++  +   ++   VP  IL  K
Sbjct: 565 EVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETK 624

Query: 634 RLPKTRSGKVMRRLLRKIITSEAQELG 660
            +P T +GK +   +++II  +A E G
Sbjct: 625 GIPYTLNGKKVEVAVKQIIAGKAVEQG 651


>gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Homo
           sapiens]
          Length = 579

 Score =  169 bits (427), Expect = 1e-41
 Identities = 151/524 (28%), Positives = 240/524 (45%), Gaps = 33/524 (6%)

Query: 130 WERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACARI 188
           W  +  G E++ ++ EL + + + AN L    G+  GDR+ + +P  P      +AC R 
Sbjct: 79  WWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRT 138

Query: 189 GAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHV 248
           G V        + + L  R+  ++ K +IT +          L   VD     CP++Q  
Sbjct: 139 GTVMIPGVTQLTEKDLKYRLQASRAKSIITSDS---------LAPRVDAISAECPSLQTK 189

Query: 249 LVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQ 308
           L+   +     +   ++  E   A  +  C      S D L + +TSG+TG PK + H+Q
Sbjct: 190 LLVSDSSRPGWLNFRELLRE---ASTEHNCMRTK--SRDPLAIYFTSGTTGAPKMVEHSQ 244

Query: 309 AGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPN 368
           + Y L    + +        DIF    D GW+   ++ ++    NG+   + E   V  +
Sbjct: 245 SSYGLGFVASGRRWVALTESDIFWNTTDTGWVKA-AWTLFSAWPNGSCIFVHELPRV--D 301

Query: 369 AGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWE-W 427
           A     T+ +  I      PT  RLL++     + +Y   SLR   + GE +N +  E W
Sbjct: 302 AKVILNTLSKFPITTLCCVPTIFRLLVQED---LTRYQFQSLRHCLTGGEALNPDVREKW 358

Query: 428 LHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSV 487
            H+    +   L + + Q+ET  IC  P+  +  +  +   A  P+   V ++ DE   +
Sbjct: 359 KHQ----TGVELYEGYGQSETVVICANPKGMKIKSGSM-GKASPPYD--VQIVDDEGNVL 411

Query: 488 VEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITG 547
             G   + A+ I    P      Y D+     A  +    +Y TGD A   + GY+   G
Sbjct: 412 PPGEEGNVAVRIRPTRPFCFFNCYLDNPEKTAASEQG--DFYITGDRARMDKDGYFWFMG 469

Query: 548 RMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD--SAGDS 605
           R DDVIN S +R+G  E+E A+A+HPAV ESAV+  P  I+GE   AFIV+    S+ D 
Sbjct: 470 RNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDP 529

Query: 606 DVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
           + + +EL+  V    A Y  P ++  V  LPKT SGK+ R  LR
Sbjct: 530 EALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLR 573


>gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo
           sapiens]
          Length = 577

 Score =  162 bits (410), Expect = 1e-39
 Identities = 148/531 (27%), Positives = 239/531 (45%), Gaps = 45/531 (8%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W  +  G E+   +REL E + + AN L    G+ RGDRVA+ +P  P     +L C R
Sbjct: 69  LWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIR 128

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
            G +         +  +  R+  +K K ++       G  V++    VD     CP+++ 
Sbjct: 129 AGLIFMPGTIQMKSTDILYRLQMSKAKAIVA------GDEVIQE---VDTVASECPSLRI 179

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+      K   G L+       A     C     GS++   + +TSG++G+PK   H+
Sbjct: 180 KLLV---SEKSCDGWLNFKKLLNEASTTHHCV--ETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 308 QAGYLLYAALTHKLVFDH-----QPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFES 362
                 Y++L  K   D      Q  DI   ++D GWI      +  P   GA + +   
Sbjct: 235 ------YSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLL 288

Query: 363 TPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINC 422
               P      +T+    I    GAP   R+LL+     +  Y    L+   +VGE +  
Sbjct: 289 PKFDPLV--ILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCVTVGESLLP 343

Query: 423 EAWE-WLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLM 481
           E  E W  +   D R    +++ QTETG  C+  +  +    I P             ++
Sbjct: 344 ETLENWRAQTGLDIR----ESYGQTETGLTCMVSKTMK----IKPGYMGTAASCYDVQII 395

Query: 482 DEKGSVVE-GSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG 540
           D+KG+V+  G+     + +    P    + Y D+     A  +    ++  GD   + E 
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRG--DFWLLGDRGIKDED 453

Query: 541 GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD 600
           GY+Q  GR DD+IN SG+R+G +E+E+A+ +HPAV E+AVI  P  ++GE   AF+V+  
Sbjct: 454 GYFQFMGRADDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLAS 513

Query: 601 S--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
              + D + + +EL+  V +  A Y  P +I  V  LPKT +GK+ R  LR
Sbjct: 514 QFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLR 564


>gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 2 [Homo sapiens]
          Length = 571

 Score =  155 bits (392), Expect = 1e-37
 Identities = 149/535 (27%), Positives = 234/535 (43%), Gaps = 59/535 (11%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W  +  G E+   +REL E + + AN L    G+ RGDRVA+ +P  P     +L C R
Sbjct: 69  LWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGCIR 128

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
            G +         +  +  R+  +K K ++       G  V++    VD     CP+++ 
Sbjct: 129 AGLIFMPGTIQMKSTDILYRLQMSKAKAIVA------GDEVIQE---VDTVASECPSLRI 179

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+      K   G L+       A     C     GS++   + +TSG++G+PK   H+
Sbjct: 180 KLLV---SEKSCDGWLNFKKLLNEASTTHHCV--ETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 308 QAGYLLYAALTHKLVFDH-----QPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFES 362
                 Y++L  K   D      Q  DI   ++D GWI      + G L    T      
Sbjct: 235 ------YSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTF 284

Query: 363 TPVYPNAGRY--WETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420
             + P        +T+    I    GAP   R+LL+     +  Y    L+   + GE +
Sbjct: 285 VHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCLAGGESL 341

Query: 421 NCEAWE-WLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRP-FFGIVP 478
             E  E W  +   D R    + + QTETG  C+  +           M ++P + G   
Sbjct: 342 LPETLENWRAQTGLDIR----EFYGQTETGLTCMVSK----------TMKIKPGYMGTAA 387

Query: 479 VLMDEKG-SVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPG-YYFTGDGAY 536
              D +  + V GS  +G L     + G     +  HQ   D       G ++  GD   
Sbjct: 388 SCYDVQVIAFVHGSPRAGDL----GFAGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGI 443

Query: 537 RTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFI 596
           + E GY+Q  GR DD+IN SG+R+G +E+E+A+  HPAV E+AVI  P  ++GE   AF+
Sbjct: 444 KDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFV 503

Query: 597 VVKDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
           ++     + D + + +EL+  V +  A Y  P +I  V  LPKT +GK+ R  LR
Sbjct: 504 ILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 558


>gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 1 [Homo sapiens]
          Length = 571

 Score =  155 bits (392), Expect = 1e-37
 Identities = 149/535 (27%), Positives = 234/535 (43%), Gaps = 59/535 (11%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W  +  G E+   +REL E + + AN L    G+ RGDRVA+ +P  P     +L C R
Sbjct: 69  LWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGCIR 128

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
            G +         +  +  R+  +K K ++       G  V++    VD     CP+++ 
Sbjct: 129 AGLIFMPGTIQMKSTDILYRLQMSKAKAIVA------GDEVIQE---VDTVASECPSLRI 179

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+      K   G L+       A     C     GS++   + +TSG++G+PK   H+
Sbjct: 180 KLLV---SEKSCDGWLNFKKLLNEASTTHHCV--ETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 308 QAGYLLYAALTHKLVFDH-----QPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFES 362
                 Y++L  K   D      Q  DI   ++D GWI      + G L    T      
Sbjct: 235 ------YSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTF 284

Query: 363 TPVYPNAGRY--WETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420
             + P        +T+    I    GAP   R+LL+     +  Y    L+   + GE +
Sbjct: 285 VHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCLAGGESL 341

Query: 421 NCEAWE-WLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRP-FFGIVP 478
             E  E W  +   D R    + + QTETG  C+  +           M ++P + G   
Sbjct: 342 LPETLENWRAQTGLDIR----EFYGQTETGLTCMVSK----------TMKIKPGYMGTAA 387

Query: 479 VLMDEKG-SVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPG-YYFTGDGAY 536
              D +  + V GS  +G L     + G     +  HQ   D       G ++  GD   
Sbjct: 388 SCYDVQVIAFVHGSPRAGDL----GFAGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGI 443

Query: 537 RTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFI 596
           + E GY+Q  GR DD+IN SG+R+G +E+E+A+  HPAV E+AVI  P  ++GE   AF+
Sbjct: 444 KDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFV 503

Query: 597 VVKDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
           ++     + D + + +EL+  V +  A Y  P +I  V  LPKT +GK+ R  LR
Sbjct: 504 ILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 558


>gi|157311624 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  151 bits (382), Expect = 2e-36
 Identities = 145/533 (27%), Positives = 235/533 (44%), Gaps = 49/533 (9%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W  +  G E+   +REL E + + AN L    G+ RGDRVA+ +P  P     +L C R
Sbjct: 69  LWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIR 128

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
            G +         +  +  R+  +K K ++       G  V++    VD     CP+++ 
Sbjct: 129 AGLIFMPGTIQMKSTDILYRLQMSKAKAIVA------GDEVIQE---VDTVASECPSLRI 179

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+      K   G L+       A     C     GS++   + +TSG++G+PK   H+
Sbjct: 180 KLLV---SEKSCDGWLNFKKLLNEASTTHHCV--ETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 308 QAGYLLYAALTHKLVFDH-----QPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFES 362
                 Y++L  K   D      Q  DI   ++D GWI      + G L    T      
Sbjct: 235 ------YSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTF 284

Query: 363 TPVYPNAGRY--WETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420
             + P        +T+    I    GAP   R+LL+     +  Y    L+   + GE +
Sbjct: 285 VHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCLAGGESL 341

Query: 421 NCEAWE-WLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPV 479
             E  E W  +   D R    + + QTETG  C+  +  +    I P             
Sbjct: 342 LPETLENWRAQTGLDIR----EFYGQTETGLTCMVSKTMK----IKPGYMGTAASCYDVQ 393

Query: 480 LMDEKGSVVE-GSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRT 538
           ++D+KG+V+  G+     + +    P    + Y ++     A  +    ++  GD   + 
Sbjct: 394 VIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRG--DFWLLGDRGIKD 451

Query: 539 EGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVV 598
           E GY+Q  GR DD+IN SG+R+G +E+E+A+  HPAV E+AVI  P  ++GE   AF+++
Sbjct: 452 EDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVIL 511

Query: 599 KDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
                + D + + +EL+  V +  A Y  P +I  V  LPKT +GK+ R  LR
Sbjct: 512 ASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 564


>gi|157311622 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  151 bits (382), Expect = 2e-36
 Identities = 145/533 (27%), Positives = 235/533 (44%), Gaps = 49/533 (9%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W  +  G E+   +REL E + + AN L    G+ RGDRVA+ +P  P     +L C R
Sbjct: 69  LWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIR 128

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
            G +         +  +  R+  +K K ++       G  V++    VD     CP+++ 
Sbjct: 129 AGLIFMPGTIQMKSTDILYRLQMSKAKAIVA------GDEVIQE---VDTVASECPSLRI 179

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+      K   G L+       A     C     GS++   + +TSG++G+PK   H+
Sbjct: 180 KLLV---SEKSCDGWLNFKKLLNEASTTHHCV--ETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 308 QAGYLLYAALTHKLVFDH-----QPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFES 362
                 Y++L  K   D      Q  DI   ++D GWI      + G L    T      
Sbjct: 235 ------YSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTF 284

Query: 363 TPVYPNAGRY--WETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI 420
             + P        +T+    I    GAP   R+LL+     +  Y    L+   + GE +
Sbjct: 285 VHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCLAGGESL 341

Query: 421 NCEAWE-WLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPV 479
             E  E W  +   D R    + + QTETG  C+  +  +    I P             
Sbjct: 342 LPETLENWRAQTGLDIR----EFYGQTETGLTCMVSKTMK----IKPGYMGTAASCYDVQ 393

Query: 480 LMDEKGSVVE-GSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRT 538
           ++D+KG+V+  G+     + +    P    + Y ++     A  +    ++  GD   + 
Sbjct: 394 VIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRG--DFWLLGDRGIKD 451

Query: 539 EGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVV 598
           E GY+Q  GR DD+IN SG+R+G +E+E+A+  HPAV E+AVI  P  ++GE   AF+++
Sbjct: 452 EDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVIL 511

Query: 599 KDS--AGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
                + D + + +EL+  V +  A Y  P +I  V  LPKT +GK+ R  LR
Sbjct: 512 ASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 564


>gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]
          Length = 615

 Score =  124 bits (310), Expect = 4e-28
 Identities = 143/571 (25%), Positives = 240/571 (42%), Gaps = 74/571 (12%)

Query: 114 CLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMP 173
           CL+   ++ PE  AL+   ++    VR+T+ +L E   + A+ L   G+ +GDR+ ++ P
Sbjct: 77  CLETTAQRVPEREALVVLHED----VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGP 132

Query: 174 VSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKK 233
            S   V   LA A+ G +   +   + A  L   +    CK ++   Q         LK+
Sbjct: 133 NSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQ 192

Query: 234 IVDEAVKHCPTVQHV----LVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPES------- 282
           I       CP V++     L + R  +   +  +D PL   +  ++ V A  +       
Sbjct: 193 I-------CPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQL 245

Query: 283 ------MGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQ---------- 326
                 +   D + + +TSG+TG PKG   +    +  + +  + +  H+          
Sbjct: 246 QYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMIL 305

Query: 327 PGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYG 386
           P  ++ C   +G + G        L  GAT +L  ++P++ N  +  E + R +    YG
Sbjct: 306 PNPLYHC---LGSVAGTMMC----LMYGATLIL--ASPIF-NGKKALEAISRERGTFLYG 355

Query: 387 APTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQT 446
            PT    +L   D     YD S++      G P   E    +   +      LV  +  T
Sbjct: 356 TPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAIINKINMK--DLVVAYGTT 411

Query: 447 ETGGICIAPRPS---EEGAE----ILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCI 499
           E   +  A  P    E+ AE    I+P    R        +M+ +   +   N  G LCI
Sbjct: 412 ENSPVTFAHFPEDTVEQKAESVGRIMPHTEAR--------IMNMEAGTLAKLNTPGELCI 463

Query: 500 SQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHR 559
                 +    +G+ Q+  +A  +    +Y+TGD A   E G+ +I GR  D+I   G  
Sbjct: 464 RGYCVMLG--YWGEPQKTEEAVDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGEN 519

Query: 560 LGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATK 619
           +  AE+ED    HP V E  V+G   D  GE   A I +KD     +  V+E+K+    K
Sbjct: 520 IYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFCKGK 576

Query: 620 IAKYAVPDEILVVKRLPKTRSGKVMRRLLRK 650
           I+ + +P  I+ V   P T SGK+ +  LR+
Sbjct: 577 ISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 607


>gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 135/551 (24%), Positives = 224/551 (40%), Gaps = 88/551 (15%)

Query: 140 RITYRELLETTCRLANTLKR-----HGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTV 194
           R TYREL   + RL+  + R      G  R +RV+         V A  A    G V   
Sbjct: 65  RHTYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVP 124

Query: 195 IFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRT 254
           ++    A  L   I D++  VV+   + L     V ++K+    +   P +         
Sbjct: 125 LYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPV-VRKLGVPLLPLTPAI--------- 174

Query: 255 DNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGY-LL 313
               + G ++ P E        V  PE         ++YTSG+TG PKG++ T      +
Sbjct: 175 ----YTGAVEEPAE--------VPVPEQGWRNKGAMIIYTSGTTGRPKGVLSTHQNIRAV 222

Query: 314 YAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF-ESTPVYPNAGRY 372
              L HK  +     D+   V  +  + G    +  PL  GAT V+  E +P      + 
Sbjct: 223 VTGLVHKWAWTKD--DVILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQ-----QV 275

Query: 373 WE---TVERLKINQFYGAPTAVRLLLKYGDA-WVKKYDRSSLRTL----------GSVGE 418
           WE   + E  +IN F   PT    L++Y D  + + + +  LR +          GS   
Sbjct: 276 WEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAAL 335

Query: 419 PINC-EAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIV 477
           P+   E W+    + G    TL++ +  TE G     P  +   A  LP     P  G+ 
Sbjct: 336 PLPVLEKWK---NITGH---TLLERYGMTEIGMALSGPLTT---AVRLPGSVGTPLPGVQ 386

Query: 478 PVLM-----------------DEKGSVVEGS--NVSGALCISQAWPGMARTIYGDHQRFV 518
             ++                 DE+G+ V        G L +    P + R  +   +   
Sbjct: 387 VRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRG--PSVFREYWNKPEETK 444

Query: 519 DAYFKAYPGYYFTGDGAYRTEGGYYQITGRMD-DVINISGHRLGTAEIEDAIADHPAVPE 577
            A+     G++ TGD     +G Y+ I GR   D+I   G+++   E+E  +  HP++ +
Sbjct: 445 SAF--TLDGWFKTGDTVVFKDGQYW-IRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITD 501

Query: 578 SAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPK 637
            AVIG P    G+   A + +++    S    +ELK      +A YAVP E+++V+ +P+
Sbjct: 502 VAVIGVPDMTWGQRVTAVVTLREGHSLSH---RELKEWARNVLAPYAVPSELVLVEEIPR 558

Query: 638 TRSGKVMRRLL 648
            + GK+ ++ L
Sbjct: 559 NQMGKIDKKAL 569


>gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 135/551 (24%), Positives = 224/551 (40%), Gaps = 88/551 (15%)

Query: 140 RITYRELLETTCRLANTLKR-----HGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTV 194
           R TYREL   + RL+  + R      G  R +RV+         V A  A    G V   
Sbjct: 65  RHTYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVP 124

Query: 195 IFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRT 254
           ++    A  L   I D++  VV+   + L     V ++K+    +   P +         
Sbjct: 125 LYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPV-VRKLGVPLLPLTPAI--------- 174

Query: 255 DNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGY-LL 313
               + G ++ P E        V  PE         ++YTSG+TG PKG++ T      +
Sbjct: 175 ----YTGAVEEPAE--------VPVPEQGWRNKGAMIIYTSGTTGRPKGVLSTHQNIRAV 222

Query: 314 YAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF-ESTPVYPNAGRY 372
              L HK  +     D+   V  +  + G    +  PL  GAT V+  E +P      + 
Sbjct: 223 VTGLVHKWAWTKD--DVILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQ-----QV 275

Query: 373 WE---TVERLKINQFYGAPTAVRLLLKYGDA-WVKKYDRSSLRTL----------GSVGE 418
           WE   + E  +IN F   PT    L++Y D  + + + +  LR +          GS   
Sbjct: 276 WEKFLSSETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAAL 335

Query: 419 PINC-EAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIV 477
           P+   E W+    + G    TL++ +  TE G     P  +   A  LP     P  G+ 
Sbjct: 336 PLPVLEKWK---NITGH---TLLERYGMTEIGMALSGPLTT---AVRLPGSVGTPLPGVQ 386

Query: 478 PVLM-----------------DEKGSVVEGS--NVSGALCISQAWPGMARTIYGDHQRFV 518
             ++                 DE+G+ V        G L +    P + R  +   +   
Sbjct: 387 VRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRG--PSVFREYWNKPEETK 444

Query: 519 DAYFKAYPGYYFTGDGAYRTEGGYYQITGRMD-DVINISGHRLGTAEIEDAIADHPAVPE 577
            A+     G++ TGD     +G Y+ I GR   D+I   G+++   E+E  +  HP++ +
Sbjct: 445 SAF--TLDGWFKTGDTVVFKDGQYW-IRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITD 501

Query: 578 SAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPK 637
            AVIG P    G+   A + +++    S    +ELK      +A YAVP E+++V+ +P+
Sbjct: 502 VAVIGVPDMTWGQRVTAVVTLREGHSLSH---RELKEWARNVLAPYAVPSELVLVEEIPR 558

Query: 638 TRSGKVMRRLL 648
            + GK+ ++ L
Sbjct: 559 NQMGKIDKKAL 569


>gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Homo
           sapiens]
          Length = 480

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 100/437 (22%), Positives = 185/437 (42%), Gaps = 35/437 (8%)

Query: 129 IWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACAR 187
           +W+    G E + ++  + + + + A+ L     +  GDR+ I +P +P A    LAC R
Sbjct: 74  LWKVSAKGEEDKWSFERMTQLSKKAASILSDTCALSHGDRLMIILPPTPEAYWICLACVR 133

Query: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQH 247
           +G          +A+ +  ++  +K + ++  N+ +          +V+ AV  CPT++ 
Sbjct: 134 LGITFVPGSPQLTAKKIRYQLRMSKAQCIVA-NEAMA--------PVVNSAVSDCPTLKT 184

Query: 248 VLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHT 307
            L+     +K + G LD     ++A   P        S+D + + +T G+TG PK + ++
Sbjct: 185 KLLV---SDKSYDGWLDFKKLIQVAP--PKQTYMRTKSQDPMAIFFTKGTTGAPKMVEYS 239

Query: 308 QAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYP 367
           Q G  +  +   +   D QP D+   + D    +     V G    GA   L       P
Sbjct: 240 QYGLGMGFSQASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTWFQGACVFLCHMPTFCP 299

Query: 368 NAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEW 427
                   + R  I      P   + LL++       Y   SL+   + G PI+    E 
Sbjct: 300 ET--VLNVLSRFPITTLSANPEMYQELLQH--KCFTSYRFKSLKQCVAAGGPISPGVIED 355

Query: 428 LHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSV 487
             R+   ++  + + + QTETG +C   +      ++ P+   +P    +  ++DE  ++
Sbjct: 356 WKRI---TKLDIYEGYGQTETGLLCATSKT----IKLKPSSLGKPLPPYIVQIVDENSNL 408

Query: 488 V---EGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGY-YFTGDGAYRTEGGYY 543
           +   E  N++  + ++Q       ++Y  H    + Y  A     Y TGD     E GY+
Sbjct: 409 LPPGEEGNIAIRIKLNQP-----ASLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYF 463

Query: 544 QITGRMDDVINISGHRL 560
             +GR+DDV N  G RL
Sbjct: 464 WWSGRVDDVANALGQRL 480


>gi|42544134 SA hypertension-associated homolog isoform 2 [Homo
           sapiens]
          Length = 438

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 95/386 (24%), Positives = 159/386 (41%), Gaps = 40/386 (10%)

Query: 94  DFSTGKIGWFLGGQLNVSVNCLDQ-----HVRKSPESVALIWERDEPGTEVRITYRELLE 148
           DF  G   +F     N + + LDQ        K P + A  W  +  G E+R ++ EL  
Sbjct: 49  DFKLGIPEYF-----NFAKDVLDQWTDKEKAGKKPSNPAFWWI-NRNGEEMRWSFEELGS 102

Query: 149 TTCRLANTLKRH-GVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGR 207
            + + AN L     + RGDRV + +P  P    A +AC R G V        + + +  R
Sbjct: 103 LSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYR 162

Query: 208 INDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPL 267
           +  +K   +IT +          L   VD     C  +   L+    +++   G+L   +
Sbjct: 163 LQSSKANCIITNDV---------LAPAVDAVASKCENLHSKLIVSE-NSREGWGNLKELM 212

Query: 268 EQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQP 327
           +   A +   C        +++ + +TSG++G PK   HT + + L  ++  +   D  P
Sbjct: 213 KH--ASDSHTCVKTK--HNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTP 268

Query: 328 GDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGA 387
            D+    +D GW       V+ P   GA           P +    +T+ +  I  F  A
Sbjct: 269 SDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTS--ILQTLSKYPITVFCSA 326

Query: 388 PTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWE-WLHRVVGDSRCTLVDTWWQT 446
           PT  R+L++     +  Y   SL+   S GEPI  +  E W ++   D    + + + QT
Sbjct: 327 PTVYRMLVQND---ITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLD----IYEGYGQT 379

Query: 447 ETGGICIAPRPSEEGAEILPAMAMRP 472
           ET  IC     + +G +I P    +P
Sbjct: 380 ETVLIC----GNFKGMKIKPGSMGKP 401


>gi|38524616 solute carrier family 27, member 1 [Homo sapiens]
          Length = 646

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 128/560 (22%), Positives = 214/560 (38%), Gaps = 67/560 (11%)

Query: 119 VRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLA 178
           V++ PE +AL+    + GT    T+ +L   +  +AN  ++ G   GD VAI++   P  
Sbjct: 86  VQRQPERLALV----DAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEF 141

Query: 179 VAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVD-- 236
           V   L  A+ G    ++      E LA  +  +  K +I       GG +V     V   
Sbjct: 142 VGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIF------GGEMVAAVAEVSGH 195

Query: 237 ---EAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLY 293
                +K C      L         H+ D   PL +E A   P+    S G +D LF +Y
Sbjct: 196 LGKSLIKFC---SGDLGPEGILPDTHLLD---PLLKE-ASTAPLAQIPSKGMDDRLFYIY 248

Query: 294 TSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCN 353
           TSG+TG+PK  +   + Y   AA  H   +  Q  D+      +    G+   V   L  
Sbjct: 249 TSGTTGLPKAAIVVHSRYYRMAAFGHH-AYRMQAADVLYDCLPLYHSAGNIIGVGQCLIY 307

Query: 354 GATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTL 413
           G T VL +      +A R+W+   +             R LLK      ++  R  L   
Sbjct: 308 GLTVVLRKKF----SASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRL--- 360

Query: 414 GSVGEPINCEAWEWLHRVVG-----------DSRCTLVDTWWQTETGGI--CIAP----- 455
            +VG  +    WE      G           +  C++ +   +  + G    I P     
Sbjct: 361 -AVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPI 419

Query: 456 ---RPSEEGAEILPAMAMRPFFGI-VPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIY 511
              + +E+  E+L     R   G+ +P    E G +V   N    L     +   + T  
Sbjct: 420 RLVKVNEDTMELL-----RDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESAT-- 472

Query: 512 GDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIAD 571
              ++   + F      Y +GD     E GY     R  D     G  + T E+E  ++ 
Sbjct: 473 --SKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSR 530

Query: 572 HPAVPESAVIGYP-HDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEIL 630
                + AV G     ++G+A  A +    S  D + + QEL+ +    +A YA P  + 
Sbjct: 531 LLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKV----LAPYARPIFLR 586

Query: 631 VVKRLPKTRSGKVMRRLLRK 650
           ++ ++  T + K+ +  L++
Sbjct: 587 LLPQVDTTGTFKIQKTRLQR 606


>gi|40807357 solute carrier family 27 (fatty acid transporter),
           member 4 [Homo sapiens]
          Length = 643

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 68/258 (26%), Positives = 120/258 (46%), Gaps = 22/258 (8%)

Query: 119 VRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLA 178
           VR+ P+  ALI+E    GT+   T+R+L E +  +AN L+  G+  GD  AI+M      
Sbjct: 84  VRRHPDKTALIFE----GTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEF 139

Query: 179 VAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEA 238
           V   L  A++G    +I      ++L   +  ++ + ++  ++      + E+   +D +
Sbjct: 140 VGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSE--MASAICEVHASLDPS 197

Query: 239 VK-HCP-TVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSG 296
           +   C  + +   V   T++      LD PL ++  K  P C  +  G  D LF +YTSG
Sbjct: 198 LSLFCSGSWEPGAVPPSTEH------LD-PLLKDAPKHLPSCPDK--GFTDKLFYIYTSG 248

Query: 297 STGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGAT 356
           +TG+PK  +   + Y   AAL +   F  +P DI      +    G+   +   L +G T
Sbjct: 249 TTGLPKAAIVVHSRYYRMAALVY-YGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMT 307

Query: 357 SVLFESTPVYPNAGRYWE 374
            V+ +      +A R+W+
Sbjct: 308 VVIRKKF----SASRFWD 321



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 33/139 (23%), Positives = 57/139 (41%), Gaps = 5/139 (3%)

Query: 513 DHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADH 572
           ++++     FK     Y TGD     E GY     R  D     G  + T E+E  ++  
Sbjct: 469 NNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRL 528

Query: 573 PAVPESAVIGYPHDIKG-EAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILV 631
             + + AV G   ++ G E       V    G+ D  ++    ++  ++  YA P  + +
Sbjct: 529 LDMADVAVYGV--EVPGTEGRAGMAAVASPTGNCD--LERFAQVLEKELPLYARPIFLRL 584

Query: 632 VKRLPKTRSGKVMRRLLRK 650
           +  L KT + K  +  LRK
Sbjct: 585 LPELHKTGTYKFQKTELRK 603


>gi|62865631 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 116/566 (20%), Positives = 218/566 (38%), Gaps = 62/566 (10%)

Query: 106 GQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHG-VHR 164
           G+L   ++    H ++ P    +I+E D        TY+++ + + R+A+    H  + +
Sbjct: 51  GELVTVLDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKK 104

Query: 165 GDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLR 224
           GD VA+ M   P  V      A++G V   +     + SL   I     + ++       
Sbjct: 105 GDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVG----- 159

Query: 225 GGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMG 284
                +L   V+E +   P++   +      + V  G + +  +   + ++PV     + 
Sbjct: 160 ----ADLLGTVEEIL---PSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVV 212

Query: 285 S--EDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVA-DIGWIT 341
           S  +     ++TSG+TG+PK  V +Q   L  +A+             FGC A DI +IT
Sbjct: 213 SLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLW----------AFGCTAHDIVYIT 262

Query: 342 GHSY-------VVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLL 394
              Y        + G +  GAT VL +      +A ++W   ++  +  F       R L
Sbjct: 263 LPLYHSSAAILGISGCVELGATCVLKKKF----SASQFWSDCKKYDVTVFQYIGELCRYL 318

Query: 395 LKYGDAWVKKYDRSSLRTLGSVGEPINCEAW-EWLHRVVGDSRCTLV-----DTWWQTET 448
            K      K+      +   ++G  I  + W E+L R      C L         +   T
Sbjct: 319 CKQS----KREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYT 374

Query: 449 GGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQA-----W 503
           G I    R +     +     ++  F     + +E+G  +        L IS+      +
Sbjct: 375 GRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPF 434

Query: 504 PGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTA 563
            G A        + +   FK    Y  TGD   + +  +     R  D     G  + T 
Sbjct: 435 FGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATT 494

Query: 564 EIEDAIADHPAVPESAVIGYP-HDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAK 622
           E+ D I     + E+ V G      +G A  A I++K    ++ + ++++   V T +  
Sbjct: 495 EVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKP---NTSLDLEKVYEQVVTFLPA 551

Query: 623 YAVPDEILVVKRLPKTRSGKVMRRLL 648
           YA P  + + +++  T + K+++  L
Sbjct: 552 YACPRFLRIQEKMEATGTFKLLKHQL 577


>gi|13325055 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 116/566 (20%), Positives = 218/566 (38%), Gaps = 62/566 (10%)

Query: 106 GQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHG-VHR 164
           G+L   ++    H ++ P    +I+E D        TY+++ + + R+A+    H  + +
Sbjct: 51  GELVTVLDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKK 104

Query: 165 GDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLR 224
           GD VA+ M   P  V      A++G V   +     + SL   I     + ++       
Sbjct: 105 GDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVG----- 159

Query: 225 GGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMG 284
                +L   V+E +   P++   +      + V  G + +  +   + ++PV     + 
Sbjct: 160 ----ADLLGTVEEIL---PSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVV 212

Query: 285 S--EDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVA-DIGWIT 341
           S  +     ++TSG+TG+PK  V +Q   L  +A+             FGC A DI +IT
Sbjct: 213 SLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLW----------AFGCTAHDIVYIT 262

Query: 342 GHSY-------VVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLL 394
              Y        + G +  GAT VL +      +A ++W   ++  +  F       R L
Sbjct: 263 LPLYHSSAAILGISGCVELGATCVLKKKF----SASQFWSDCKKYDVTVFQYIGELCRYL 318

Query: 395 LKYGDAWVKKYDRSSLRTLGSVGEPINCEAW-EWLHRVVGDSRCTLV-----DTWWQTET 448
            K      K+      +   ++G  I  + W E+L R      C L         +   T
Sbjct: 319 CKQS----KREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYT 374

Query: 449 GGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQA-----W 503
           G I    R +     +     ++  F     + +E+G  +        L IS+      +
Sbjct: 375 GRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPF 434

Query: 504 PGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTA 563
            G A        + +   FK    Y  TGD   + +  +     R  D     G  + T 
Sbjct: 435 FGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATT 494

Query: 564 EIEDAIADHPAVPESAVIGYP-HDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAK 622
           E+ D I     + E+ V G      +G A  A I++K    ++ + ++++   V T +  
Sbjct: 495 EVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKP---NTSLDLEKVYEQVVTFLPA 551

Query: 623 YAVPDEILVVKRLPKTRSGKVMRRLL 648
           YA P  + + +++  T + K+++  L
Sbjct: 552 YACPRFLRIQEKMEATGTFKLLKHQL 577


>gi|13236579 solute carrier family 27 member 3 [Homo sapiens]
          Length = 730

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 92/444 (20%), Positives = 168/444 (37%), Gaps = 42/444 (9%)

Query: 247 HVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKG--I 304
           H+  A    +   + DL   +  E+    P          D    ++TSG+TG+PK   I
Sbjct: 288 HLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARI 347

Query: 305 VHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTP 364
            H +   +L     ++L   HQ  D+      +  ++G    + G +  GAT VL     
Sbjct: 348 SHLK---ILQCQGFYQLCGVHQE-DVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKF- 402

Query: 365 VYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEA 424
              +AG++WE  ++ ++  F       R L+    +  ++  +  L    +VG  +  + 
Sbjct: 403 ---SAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRL----AVGSGLRPDT 455

Query: 425 WEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGA---------EILPAMAMRPFFG 475
           WE   R  G  +  +++T+  TE G +       + GA          I P   +R    
Sbjct: 456 WERFVRRFGPLQ--VLETYGLTE-GNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVT 512

Query: 476 IVPVLMDEKGSVVEGSNVSGALC---ISQAWP--GMARTIYGDHQRFVDAYFKAYPGYYF 530
               + D +G  +  S     L    +SQ  P  G A        + +   F+    ++ 
Sbjct: 513 TGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFN 572

Query: 531 TGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYP-HDIKG 589
           TGD     + G+ +   R  D     G  + T E+ +       + E  V G      +G
Sbjct: 573 TGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEG 632

Query: 590 EAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLR 649
            A  A +V++       + + +L + V+  +  YA P  + + + L  T + K  +    
Sbjct: 633 RAGMAALVLRPPHA---LDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQK---- 685

Query: 650 KIITSEAQELGDTTTLEDPSIIAE 673
                 A E  D +TL DP  + +
Sbjct: 686 ---VRMANEGFDPSTLSDPLYVLD 706


>gi|13325057 solute carrier family 27 (fatty acid transporter),
           member 5 [Homo sapiens]
          Length = 690

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 113/568 (19%), Positives = 204/568 (35%), Gaps = 62/568 (10%)

Query: 112 VNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRH-----GVHRGD 166
           V+  ++  R  P    L+W     G+   +T+ EL    C+ A  LK        +  G+
Sbjct: 117 VDAFERRARAQPGRALLVWTGPGAGS---VTFGELDARACQAAWALKAELGDPASLCAGE 173

Query: 167 RVAIYMPVSPL--AVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLR 224
             A+ +  S    A+   L  A++G     I        LA  +  +  +V++  +  LR
Sbjct: 174 PTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVV-DPDLR 232

Query: 225 GGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMG 284
                 L K+  E ++ C  + H      T     +G L   L+   +   P      + 
Sbjct: 233 ESLEEILPKLQAENIR-CFYLSH------TSPTPGVGALGAALDAAPSHPVPADLRAGIT 285

Query: 285 SEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHS 344
                  +YTSG+TG+PK  + T    L  + +    +      D+   V  +  + G  
Sbjct: 286 WRSPALFIYTSGTTGLPKPAILTHERVLQMSKMLS--LSGATADDVVYTVLPLYHVMGLV 343

Query: 345 YVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKK 404
             + G L  GAT VL    P + +   +W+   +  +         +R L        + 
Sbjct: 344 VGILGCLDLGATCVL---APKF-STSCFWDDCRQHGVTVILYVGELLRYLCNIPQ---QP 396

Query: 405 YDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEI 464
            DR+    L ++G  +  + WE   +  G  R  + + +  TE G + +       GA  
Sbjct: 397 EDRTHTVRL-AMGNGLRADVWETFQQRFGPIR--IWEVYGSTE-GNMGLVNYVGRCGALG 452

Query: 465 LPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKA 524
             +  +R       V  D + +     N    + +    PG+  T     Q FV      
Sbjct: 453 KMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFV-----G 507

Query: 525 YPG-------------------YYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEI 565
           Y G                   YY TGD       G+     R+ D     G  + T E+
Sbjct: 508 YRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEV 567

Query: 566 EDAIADHPAVPESAVIGY-PHDIKGEAAFAFI-VVKDSAGDSDVVVQELKSMVATKIAKY 623
           E  ++    + +  V G      +G+   A + +      D + + Q +++     +  Y
Sbjct: 568 EGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAW----LPAY 623

Query: 624 AVPDEILVVKRLPKTRSGKVMR-RLLRK 650
           A P  I +   +  T + K+M+ RL+R+
Sbjct: 624 ATPHFIRIQDAMEVTSTFKLMKTRLVRE 651


>gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens]
          Length = 1098

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 83/372 (22%), Positives = 143/372 (38%), Gaps = 35/372 (9%)

Query: 288 MLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVV 347
           + ++L+TSG+TG+PK IV      ++      +++FD    D+    + + +       +
Sbjct: 192 LAYVLHTSGTTGIPK-IVRVPHKCIVPNIQHFRVLFDITQEDVLFLASPLTFDPS-VVEI 249

Query: 348 YGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDR 407
           +  L +GA+ ++  ++     +          ++      PT   LL ++G   +K    
Sbjct: 250 FLALSSGASLLIVPTSVKLLPSKLASVLFSHHRVTVLQATPT---LLRRFGSQLIKSTVL 306

Query: 408 S---SLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEI 464
           S   SLR L   GE           R  G+ +  + + +  TE        R  E+    
Sbjct: 307 SATTSLRVLALGGEAFPSLTVLRSWRGEGN-KTQIFNVYGITEVSSWATIYRIPEKTLNS 365

Query: 465 -----LPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVD 519
                LP     P  G V  + D  G  ++    SG + +     G  R  + D +  V 
Sbjct: 366 TLKCELPVQLGFPLLGTVVEVRDTNGFTIQEG--SGQVFLG----GRNRVCFLDDEVTVP 419

Query: 520 AYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESA 579
                  G + T       + G     GR D  I   G RL    ++    +   V   A
Sbjct: 420 LGTMRATGDFVT------VKDGEIFFLGRKDSQIKRHGKRLNIELVQQVAEELQQVESCA 473

Query: 580 VIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTR 639
           V  Y      E    F+V KD A   + + +EL+  + +    +AVPDE++++  LP T 
Sbjct: 474 VTWYNQ----EKLILFMVSKD-ASVKEYIFKELQKYLPS----HAVPDELVLIDSLPFTS 524

Query: 640 SGKVMRRLLRKI 651
            GK+    L KI
Sbjct: 525 HGKIDVSELNKI 536


>gi|227499619 solute carrier family 27 (fatty acid transporter),
           member 2 isoform 1 [Homo sapiens]
          Length = 620

 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 110/533 (20%), Positives = 200/533 (37%), Gaps = 60/533 (11%)

Query: 117 QHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRH-GVHRGDRVAIYMPVS 175
           +  R++P    L++ RDE      +TY ++   + ++A  L  H G+ +GD VA+ M   
Sbjct: 61  EKARQTPHKPFLLF-RDET-----LTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNE 114

Query: 176 PLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIV 235
           P  V   L   ++G     +     A+SL         KV++   +         +++I+
Sbjct: 115 PAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPE-----LQAAVEEIL 169

Query: 236 DEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQ-EMAKEDPVCAPESMGSEDML----F 290
               K   ++ +V     TD       +D  L++ +    +P+  PES  SE        
Sbjct: 170 PSLKKDDVSIYYVSRTSNTDG------IDSFLDKVDEVSTEPI--PESWRSEVTFSTPAL 221

Query: 291 MLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGP 350
            +YTSG+TG+PK  + T         LT   V   +  D+                ++G 
Sbjct: 222 YIYTSGTTGLPKAAMITHQRIWYGTGLT--FVSGLKADDVIYITLPFYHSAALLIGIHGC 279

Query: 351 LCNGATSVLFESTPVYPNAGRYWETVERLKIN--QFYGAPTAVRLLLKYGDAWVKKYDRS 408
           +  GAT  L        +A ++W+   +  +   Q+ G       LL+Y     +K +  
Sbjct: 280 IVAGATLALRTKF----SASQFWDDCRKYNVTVIQYIGE------LLRYLCNSPQKPNDR 329

Query: 409 SLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGA------ 462
             +   ++G  +  + W    +  GD     +  ++    G I       + GA      
Sbjct: 330 DHKVRLALGNGLRGDVWRQFVKRFGD---ICIYEFYAATEGNIGFMNYARKVGAVGRVNY 386

Query: 463 ---EILPAMAMRPFFGIVPVLMDEKGSVVE--GSNVSGALC-ISQAWP--GMARTIYGDH 514
              +I+    ++        + DE G  V      V   +C I+Q  P  G A       
Sbjct: 387 LQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTE 446

Query: 515 QRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPA 574
           ++ +   FK    Y+ +GD        +     R+ D     G  + T E+ D +     
Sbjct: 447 KKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDF 506

Query: 575 VPESAVIG-YPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVP 626
           V E  V G +  D +G    A I +K+   + +   ++L   +A  +  YA P
Sbjct: 507 VQEVNVYGVHVPDHEGRIGMASIKMKE---NHEFDGKKLFQHIADYLPSYARP 556


>gi|4758332 acyl-CoA synthetase long-chain family member 4 isoform 1
           [Homo sapiens]
          Length = 670

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 37/173 (21%), Positives = 73/173 (42%), Gaps = 17/173 (9%)

Query: 141 ITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFS 200
           + Y E+        + L   G+   + +AI+       + A   C +       ++A   
Sbjct: 85  MNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLG 144

Query: 201 AESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVL-VAHRTDNKVH 259
            E++   +N+++   +IT         V  L+  +  A+     V+H++ V ++  NK  
Sbjct: 145 KEAVVHGLNESEASYLIT--------SVELLESKLKTALLDISCVKHIIYVDNKAINKAE 196

Query: 260 MGDLDVPLEQEMAKEDPVCAPESMG-------SEDMLFMLYTSGSTGMPKGIV 305
             +    +    + E+    PE++G         DM  ++YTSGSTG PKG++
Sbjct: 197 YPE-GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVM 248


>gi|12669909 acyl-CoA synthetase long-chain family member 4 isoform
           2 [Homo sapiens]
          Length = 711

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 37/173 (21%), Positives = 73/173 (42%), Gaps = 17/173 (9%)

Query: 141 ITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFS 200
           + Y E+        + L   G+   + +AI+       + A   C +       ++A   
Sbjct: 126 MNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLG 185

Query: 201 AESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVL-VAHRTDNKVH 259
            E++   +N+++   +IT         V  L+  +  A+     V+H++ V ++  NK  
Sbjct: 186 KEAVVHGLNESEASYLIT--------SVELLESKLKTALLDISCVKHIIYVDNKAINKAE 237

Query: 260 MGDLDVPLEQEMAKEDPVCAPESMG-------SEDMLFMLYTSGSTGMPKGIV 305
             +    +    + E+    PE++G         DM  ++YTSGSTG PKG++
Sbjct: 238 YPE-GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVM 289


>gi|24497589 aristaless related homeobox [Homo sapiens]
          Length = 562

 Score = 38.1 bits (87), Expect = 0.027
 Identities = 27/76 (35%), Positives = 33/76 (43%), Gaps = 6/76 (7%)

Query: 4   RTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYP---A 60
           R  G G GRLL   +G +   A      +A   A +GP G AP      A+PG  P    
Sbjct: 87  RLYGPGGGRLL---QGAAAAAAAAAAAAAAAATATAGPRGEAPPPPPPTARPGERPDGAG 143

Query: 61  LSAQAAREPAAFWGPL 76
            +A AA   AA W  L
Sbjct: 144 AAAAAAAAAAAAWDTL 159


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,703,240
Number of Sequences: 37866
Number of extensions: 1313550
Number of successful extensions: 5554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 5248
Number of HSP's gapped (non-prelim): 289
length of query: 689
length of database: 18,247,518
effective HSP length: 109
effective length of query: 580
effective length of database: 14,120,124
effective search space: 8189671920
effective search space used: 8189671920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.