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Search of human proteins with 28329439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
(824 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 1631 0.0
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 1631 0.0
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 79 1e-14
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 79 1e-14
gi|83415184 transmembrane and tetratricopeptide repeat containin... 65 3e-10
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 60 1e-08
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 59 2e-08
gi|118402596 cell division cycle protein 23 [Homo sapiens] 59 2e-08
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 57 5e-08
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 56 2e-07
gi|22749211 transmembrane and tetratricopeptide repeat containin... 53 1e-06
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 52 2e-06
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 51 4e-06
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 51 4e-06
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 51 5e-06
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 49 2e-05
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 49 2e-05
gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] 48 3e-05
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 47 9e-05
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 47 9e-05
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 47 9e-05
gi|224809432 transmembrane and tetratricopeptide repeat containi... 46 2e-04
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 44 8e-04
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 44 8e-04
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 44 8e-04
gi|164519122 LGN protein [Homo sapiens] 44 8e-04
gi|6912398 general transcription factor IIIC, polypeptide 3, 102... 42 0.002
gi|6912630 interferon-induced protein with tetratricopeptide rep... 41 0.004
gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Ho... 40 0.007
gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [H... 40 0.007
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 1631 bits (4224), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 1 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 60
MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA
Sbjct: 10 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 69
Query: 61 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 120
VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR
Sbjct: 70 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 129
Query: 121 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 180
GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR
Sbjct: 130 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 189
Query: 181 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 240
QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG
Sbjct: 190 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 249
Query: 241 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 300
NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS
Sbjct: 250 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 309
Query: 301 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 360
MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK
Sbjct: 310 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 369
Query: 361 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 420
NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN
Sbjct: 370 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 429
Query: 421 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD
Sbjct: 430 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 489
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC
Sbjct: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG
Sbjct: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
Query: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 660
DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV
Sbjct: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 669
Query: 661 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 720
ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK
Sbjct: 670 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 729
Query: 721 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 780
EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS
Sbjct: 730 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 789
Query: 781 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 824
NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Sbjct: 790 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 833
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 1631 bits (4224), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 1 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 60
MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA
Sbjct: 1 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA 60
Query: 61 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 120
VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR
Sbjct: 61 VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR 120
Query: 121 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 180
GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR
Sbjct: 121 GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR 180
Query: 181 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 240
QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG
Sbjct: 181 QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG 240
Query: 241 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 300
NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS
Sbjct: 241 NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS 300
Query: 301 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 360
MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK
Sbjct: 301 MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK 360
Query: 361 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 420
NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN
Sbjct: 361 NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN 420
Query: 421 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD
Sbjct: 421 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC
Sbjct: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG
Sbjct: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
Query: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 660
DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV
Sbjct: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV 660
Query: 661 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 720
ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK
Sbjct: 661 ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK 720
Query: 721 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 780
EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS
Sbjct: 721 EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS 780
Query: 781 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 824
NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Sbjct: 781 NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE 824
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 79.3 bits (194), Expect = 1e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 231 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 290
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 44 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 97
Query: 291 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 349
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 152
Query: 350 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 409
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 153 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 202
Query: 410 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 469
+ E A L+ N Y+ NL + + F +A
Sbjct: 203 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 234
Query: 470 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 529
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
Query: 530 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 589
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
Query: 590 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 649
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 414
Query: 650 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 709
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 415 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 472
Query: 710 ARKLKRL 716
++K+L
Sbjct: 473 DERMKKL 479
Score = 30.0 bits (66), Expect = 9.1
Identities = 23/133 (17%), Positives = 61/133 (45%)
Query: 450 SAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKE 509
+AA +NL+++ +A + A+ A +N GNT+ D + A + Y
Sbjct: 351 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 410
Query: 510 ALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPS 569
A++ + + +A N+ ++ + EA+ + + + + +A+ +++ + +
Sbjct: 411 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 470
Query: 570 QAIEWLMQVVSVI 582
E + ++VS++
Sbjct: 471 DYDERMKKLVSIV 483
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 79.3 bits (194), Expect = 1e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 231 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 290
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 54 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 107
Query: 291 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 349
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 108 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 162
Query: 350 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 409
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 163 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 212
Query: 410 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 469
+ E A L+ N Y+ NL + + F +A
Sbjct: 213 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 244
Query: 470 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 529
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 245 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 304
Query: 530 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 589
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 305 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 364
Query: 590 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 649
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 365 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 424
Query: 650 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 709
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 425 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 482
Query: 710 ARKLKRL 716
++K+L
Sbjct: 483 DERMKKL 489
Score = 30.0 bits (66), Expect = 9.1
Identities = 23/133 (17%), Positives = 61/133 (45%)
Query: 450 SAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKE 509
+AA +NL+++ +A + A+ A +N GNT+ D + A + Y
Sbjct: 361 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 420
Query: 510 ALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPS 569
A++ + + +A N+ ++ + EA+ + + + + +A+ +++ + +
Sbjct: 421 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 480
Query: 570 QAIEWLMQVVSVI 582
E + ++VS++
Sbjct: 481 DYDERMKKLVSIV 493
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 65.1 bits (157), Expect = 3e-10
Identities = 55/239 (23%), Positives = 107/239 (44%), Gaps = 4/239 (1%)
Query: 453 ATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALR 512
A+ L+ L + +D A+A Y A+ + AL N GN + + E+A K++++
Sbjct: 409 ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
Query: 513 NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI 572
+A ++ + R EA + + +S+++ P +A+
Sbjct: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
Query: 573 EWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID 632
Q + + P+ + LG LY G+ S A ++Y + + E++ LGA Y +
Sbjct: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-KAEILSPLGALYYN 587
Query: 633 TQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 691
T +E+A+Q ++ A+ +QP+Q + +L +A G ++A K T+ E CL
Sbjct: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEA---EKMTNHIVSEETGCL 643
Score = 47.0 bits (110), Expect = 7e-05
Identities = 41/197 (20%), Positives = 75/197 (38%), Gaps = 3/197 (1%)
Query: 482 YNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
+N N N + G ++A Y+ AL+ AL N+G
Sbjct: 373 HNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA 432
Query: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
L+LH L+ + N+ + E +AI L + P S L L +
Sbjct: 433 LQLHP---QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQER 489
Query: 602 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 661
+A + Y + P + ++ G + +DT EKA+ ++++A + P+ + +
Sbjct: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549
Query: 662 SCFRRSGNYQKALDTYK 678
+R G A + YK
Sbjct: 550 RLYRSLGENSMAEEWYK 566
Score = 42.4 bits (98), Expect = 0.002
Identities = 88/432 (20%), Positives = 161/432 (37%), Gaps = 68/432 (15%)
Query: 238 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEH 297
N N Q +AI YR AL P + N+G ++A Y+
Sbjct: 380 NYANFLKDQGRNKEAIYHYRTALKLYPR-----HASALNNLGTL---TRDTAEAKMYYQR 431
Query: 298 IMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTE 357
+ + P +N + F +G+ K ++ ++ IT L D KY D +++L +
Sbjct: 432 ALQLHPQ----HNRAL--FNLGNLLKSQEKKEEAIT--LLKDSIKYGPEFADAYSSLASL 483
Query: 358 AIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDL 417
E+ER AE+ T K +L N+
Sbjct: 484 LA--------EQERFKEAEEIYQTGIK---------------------NCPDSSDLHNNY 514
Query: 418 EINKAVTYLRQK---DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 474
+ T L +K Y QA+++ S A NL LY + + A +
Sbjct: 515 GVFLVDTGLPEKAVAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYK 566
Query: 475 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 534
A+ + L+ G + G YE+A + Y+EA S E + + +
Sbjct: 567 RALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625
Query: 535 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKL-- 592
EA + + E ++ IY EN +A++ + + + + P DP+V+S+L
Sbjct: 626 KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
Query: 593 --GELYDREGDKSQAFQYYYESYRYFP------CNIEVIEWLGAYYIDTQ-FWEKAIQYF 643
G + +AF+ Y + + P N+ I+ + Y+ + ++E+A+Q
Sbjct: 686 TKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLV 745
Query: 644 ERASLIQPTQVK 655
+ L++ K
Sbjct: 746 PDSKLLKENLAK 757
Score = 34.3 bits (77), Expect = 0.48
Identities = 30/156 (19%), Positives = 62/156 (39%), Gaps = 15/156 (9%)
Query: 579 VSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK 638
V +P + +V +G +A +Y + + +P + + LG DT +
Sbjct: 368 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA---E 424
Query: 639 AIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLC 698
A Y++RA + P + + + + ++A+ KD+ + PE + L L
Sbjct: 425 AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLL 484
Query: 699 TDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGS 734
+ +R ++ +EI + IK+ D S
Sbjct: 485 AE------------QERFKEAEEIYQTGIKNCPDSS 508
Score = 33.1 bits (74), Expect = 1.1
Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 7/129 (5%)
Query: 202 NLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALD 261
+LAS + E + EA YQ +KN ++ L N G + KA+ Y+ A+
Sbjct: 479 SLASLLAEQERFKEAEEIYQTGIKN--CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
Query: 262 QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDR 321
PS + M N+G + G+ S A Y+ + +A + L Y+ G
Sbjct: 537 LSPSHH-----VAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRY 591
Query: 322 EKMKKAFQK 330
E+ + +Q+
Sbjct: 592 EEALQIYQE 600
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 59.7 bits (143), Expect = 1e-08
Identities = 66/290 (22%), Positives = 114/290 (39%), Gaps = 47/290 (16%)
Query: 463 GKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSC-TEAL 521
G QA + +N N AL K F DY A +YK+ALR + C E
Sbjct: 142 GDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVR 201
Query: 522 YNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVS- 580
+G + KLN+L++A F + + L +A + EL + +I+ +Q++S
Sbjct: 202 LGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLA-VLELNNKEADSIKNGVQLLSR 260
Query: 581 ---VIPTDPQVLS-------------------------------------KLGELYDREG 600
+ P++P VL+ +L + +
Sbjct: 261 AYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQE 320
Query: 601 DKSQAFQYYYESYRYFPCNIEV-IEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLM 659
D QAFQYYY++ ++ + + LG YI E A Q FE+ P + +
Sbjct: 321 DYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKI 380
Query: 660 VASCFRRSGNYQK---ALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDA 706
+ S + S + +K A K ++P++VE L ++ ++ A
Sbjct: 381 LGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGA 430
Score = 46.6 bits (109), Expect = 9e-05
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 36/218 (16%)
Query: 476 AVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLD 535
A D NP L + N F DY K A N EA+
Sbjct: 261 AYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTE--VEAM-------------- 304
Query: 536 EALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV-LSKLGE 594
AE YQ+A + + E+ QA ++ Q + + LG+
Sbjct: 305 ---------------QAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQ 349
Query: 595 LYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK---AIQYFERASLIQP 651
+Y GDK A Q + + + +P N E ++ LG+ Y ++ EK A + ++ + P
Sbjct: 350 MYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYP 409
Query: 652 TQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVE 689
V+ + +A ++ + Q AL Y R E V+
Sbjct: 410 DDVEAWIELAQILEQT-DIQGALSAYGTATRILQEKVQ 446
Score = 36.2 bits (82), Expect = 0.13
Identities = 46/236 (19%), Positives = 86/236 (36%), Gaps = 55/236 (23%)
Query: 499 DYEKAAEFYKEALR-NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 557
DY++A ++Y +A + SS + +G Y + A CF K+ N+ E +
Sbjct: 321 DYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKI 380
Query: 558 IANIYELMEN------------------PSQAIEWLMQVVSVIPTD-------------- 585
+ ++Y E+ P W+ + TD
Sbjct: 381 LGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRI 440
Query: 586 ----------PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIE-WLGAYYIDTQ 634
P++L+ +G L+ R G+ +A +Y+ S E E + A + T
Sbjct: 441 LQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTS 500
Query: 635 F-----WEKAIQYFERASLIQ------PTQVKWQLMVASCFRRSGNYQKALDTYKD 679
+ +E ++ E L + P V L + + R GN+ +A D +K+
Sbjct: 501 YNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKE 556
Score = 33.1 bits (74), Expect = 1.1
Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 13/174 (7%)
Query: 500 YEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL------------HAI 547
Y A +E ++ D E L N+G + +L L EA FL H
Sbjct: 434 YGTATRILQEKVQADVP-PEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYY 492
Query: 548 LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQ 607
S Y +A +YE M +A + ++ P +LG + +G+ +A
Sbjct: 493 NAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASD 552
Query: 608 YYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 661
++ E+ + + + +G ++ Q W + FER TQ M+A
Sbjct: 553 WFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLA 606
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/62 (29%), Positives = 29/62 (46%)
Query: 501 EKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIAN 560
++A YK+ LRND+ A IG EA D F ++ + ++V +A+
Sbjct: 630 DRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAH 689
Query: 561 IY 562
IY
Sbjct: 690 IY 691
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 34/223 (15%)
Query: 499 DYEKAAEFYKEALRNDSS-CTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 557
DYE KE L+ C A+Y L + + E+L+ F + SA+ L Q
Sbjct: 47 DYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQ 106
Query: 558 IANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELY----------DR--------- 598
+A L+ AIE + + D ++ LG Y D+
Sbjct: 107 VARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNR 166
Query: 599 --------------EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFE 644
EGD +A + Y ++ + P N E++ LG Y+ ++KA ++
Sbjct: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
Query: 645 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPEN 687
A PT K L S + G++ AL Y+ PE+
Sbjct: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPES 269
Score = 53.5 bits (127), Expect = 8e-07
Identities = 47/194 (24%), Positives = 86/194 (44%), Gaps = 5/194 (2%)
Query: 487 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLH- 545
L ++F G ++ A E Y EA + + E +N+G+ Y L + ++A D +LH
Sbjct: 104 LKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD---QLHN 160
Query: 546 AILRNSAEVLY-QIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 604
A+ N ++ Y + I+ L + +AIE + V P + ++L+ LG LY + G +
Sbjct: 161 ALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQK 220
Query: 605 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 664
AF++ + Y P N + I G+ ++ A+ + + P + CF
Sbjct: 221 AFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280
Query: 665 RRSGNYQKALDTYK 678
Y A+ K
Sbjct: 281 FGKKKYVAAISCLK 294
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/249 (19%), Positives = 96/249 (38%), Gaps = 9/249 (3%)
Query: 431 YNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNK 490
YN+A + L +KD + NL Y K F +A A+N +R++ +
Sbjct: 124 YNEAAK----LNQKDWEISH----NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIM-L 174
Query: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
G GD +KA E YK+A+ TE L +GL Y +L +A +
Sbjct: 175 GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPT 234
Query: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
+ + + ++ + + A+ V +P P + + +G + + A
Sbjct: 235 NYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLK 294
Query: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNY 670
+ P + +++ LG ++ Q + A + A QP + +++A +
Sbjct: 295 RANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDI 354
Query: 671 QKALDTYKD 679
+ A Y +
Sbjct: 355 ENAKRAYAE 363
Score = 44.7 bits (104), Expect = 4e-04
Identities = 61/274 (22%), Positives = 111/274 (40%), Gaps = 20/274 (7%)
Query: 362 DHLRQMER------ERKAMAEKYIMTSAKLIAPVIETSFAAG--YDWCVEVVKASQYVEL 413
D+L+Q+ R + KA E Y +AKL E S G Y + + KA +L
Sbjct: 102 DNLKQVARSLFLLGKHKAAIEVY-NEAAKLNQKDWEISHNLGVCYIYLKQFNKAQD--QL 158
Query: 414 ANDLEINKA-VTY-------LRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD 465
N L +N+ +TY L + D ++A+E+ K + S + T L LY
Sbjct: 159 HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEF-SPENTELLTTLGLLYLQLGI 217
Query: 466 FAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIG 525
+ +A + A+ D N A+ G+ + +GD++ A Y+ NIG
Sbjct: 218 YQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIG 277
Query: 526 LTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTD 585
+ + + A+ C + + + ++LY + ++ M+ + A +L ++ P
Sbjct: 278 MCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM 337
Query: 586 PQVLSKLGELYDREGDKSQAFQYYYESYRYFPCN 619
++ L D A + Y E+ CN
Sbjct: 338 GELYMLLAVALTNLEDIENAKRAYAEAVHLDKCN 371
Score = 39.7 bits (91), Expect = 0.012
Identities = 35/149 (23%), Positives = 59/149 (39%), Gaps = 1/149 (0%)
Query: 555 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 614
+Y A I+ L N +++E + P L ++ G A + Y E+ +
Sbjct: 70 IYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAK 129
Query: 615 YFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKAL 674
+ E+ LG YI + + KA A + + + +M+ G+ KA+
Sbjct: 130 LNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTY-IMLGKIHLLEGDLDKAI 188
Query: 675 DTYKDTHRKFPENVECLRFLVRLCTDLGL 703
+ YK PEN E L L L LG+
Sbjct: 189 EVYKKAVEFSPENTELLTTLGLLYLQLGI 217
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 3/193 (1%)
Query: 422 AVTYLRQKDYNQAVEILKVLEKKDS-RVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
AV Y +D ++A+ I L K+D R+++ S L Y+ ++ S A D
Sbjct: 270 AVAYHNIRDIDKALSIFNELRKQDPYRIENM--DTFSNLLYVRSMKSELSYLAHNLCEID 327
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
+Y GN +EKAA +++ AL+ + A +G Y ++ A+
Sbjct: 328 KYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQA 387
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
+ + + Y + YE+++ P + + + + P D ++L LGE Y++
Sbjct: 388 YRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLN 447
Query: 601 DKSQAFQYYYESY 613
+A + Y+ +Y
Sbjct: 448 QLVEAKKCYWRAY 460
Score = 31.6 bits (70), Expect = 3.1
Identities = 31/152 (20%), Positives = 59/152 (38%), Gaps = 1/152 (0%)
Query: 528 YEKLNRLDEALDCFLKLHAI-LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDP 586
Y +L ++EAL + L + S+ ++ QIA Y + + +A+ ++ P
Sbjct: 238 YTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
Query: 587 QVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
+ + L KS+ + +E +G YY EKA YF+RA
Sbjct: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
Query: 647 SLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 678
+ P + ++ + N A+ Y+
Sbjct: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYR 389
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 57.4 bits (137), Expect = 5e-08
Identities = 107/516 (20%), Positives = 198/516 (38%), Gaps = 84/516 (16%)
Query: 202 NLASQYSVNEMYAEALNTYQ----VIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
NLA Y + AL YQ + + + + N+GN + + Y +A +Y
Sbjct: 559 NLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYE 618
Query: 258 MALDQVPSV-NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL-------KAGY 309
L P + + + K+ N+G G Y +A+ YE +++A +L KA
Sbjct: 619 QYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYC 678
Query: 310 NLTICYFAIGDREKMKKAFQKLITVPLEIDE------------DKYISPSDDPHTNLVTE 357
NL + + A+ + K ++ + L+++ ++ D +I D +
Sbjct: 679 NLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKD------ING 732
Query: 358 AIK----NDHLRQMERERKAMAEKY--IMTSAKLIAPVIETSFAAGYDWCVEVVKASQYV 411
AIK L ++R+ A Y + T+ ++I + A GY E+ +
Sbjct: 733 AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQ---KYDKALGYH-TQELEVYQELS 788
Query: 412 ELANDLEI--NKAVTYLRQKDYNQAV----EILKVLEK-KDSRVKSAAATNL-------- 456
+L + + A Y+ Y A E L + +K KD +++ N+
Sbjct: 789 DLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMN 848
Query: 457 ---SALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYK----- 508
A+ Y + A + DR A N G+ A GDYE+A ++Y+
Sbjct: 849 VMEEAIGYFEQQLAMLQQLSGNESVLDR--GRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
Query: 509 -EALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILR------NSAEVLYQIANI 561
++L +A +G + + L +AL CF K + N A+ ++ ++
Sbjct: 907 AQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSL 966
Query: 562 YELMENPSQAIEWLMQVVSVI------PTDPQVLSKLGELYDREGDKSQAFQYYY----- 610
+ + N QAI L + +++ + LG +Y + G+ A QY+
Sbjct: 967 HSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQI 1026
Query: 611 -ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFER 645
E C LG Y +E+A+ Y E+
Sbjct: 1027 AEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
Score = 52.8 bits (125), Expect = 1e-06
Identities = 103/519 (19%), Positives = 197/519 (37%), Gaps = 95/519 (18%)
Query: 239 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 297
+ + Y N K+ + + LD ++ Q + N+G F G Y +A+ ++ H
Sbjct: 240 LSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRH 299
Query: 298 IMSMAPNLK-------AGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDP 350
+ +A LK A +L Y AIGD + ++ + + + +D+ +
Sbjct: 300 QLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQ-SKDELSEARELG 358
Query: 351 HTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIE-----TSFAAGYDWCVEVV 405
+ V ++ + E + + AK + E ++ + Y +
Sbjct: 359 NMGAV-------YIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD 411
Query: 406 KASQY----VELANDLEINKAVTYLRQKDYNQAVEILKVLEK---------------KDS 446
KA Y +ELA +L + KA+ A ++ LE+ KD
Sbjct: 412 KAMSYHNYVLELAQEL-MEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDR 470
Query: 447 RVKSAAATNLSALYYMGKDFAQA----SSYADIAVNSDRY--NPAALTNKGNTVFANGDY 500
+ A++NL ++ M D+ A ++ IA Y A N GN A G Y
Sbjct: 471 AAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMY 530
Query: 501 EKAAEFYKEALR-----NDSSCTEALY-NIGLTYEKLNRLDEALDCFLKLHAILRNSAEV 554
++A +++++ L+ ND + + + N+ + Y+ L D AL + +N +
Sbjct: 531 DQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHY-------QNHLNI 583
Query: 555 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYR 614
++ + I ++ + LS LG + G+ QA YY + R
Sbjct: 584 ARELRD---------------------IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLR 622
Query: 615 YFP------CNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSG 668
P +V LG + +++A++Y+E+ L + +L A + G
Sbjct: 623 LAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQ-DLALAKDLHDKLSQAKAYCNLG 681
Query: 669 NYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQ 707
KAL F + EC ++L+ L L A+
Sbjct: 682 LAFKAL-------LNFSKAEECQKYLLSLAQSLNNSQAK 713
Score = 47.4 bits (111), Expect = 6e-05
Identities = 85/432 (19%), Positives = 159/432 (36%), Gaps = 110/432 (25%)
Query: 238 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNK----------------------------- 268
NMGN Y Y +A+K++R L VN
Sbjct: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
Query: 269 ------------QMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL-------KAGY 309
Q + + N+G G+Y A YE + +AP+L K +
Sbjct: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCH 638
Query: 310 NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMER 369
NL ++ +G+ ++ K +++ + + ++ DK + L +A+ N
Sbjct: 639 NLGYAHYCLGNYQEAVKYYEQDLALAKDL-HDKLSQAKAYCNLGLAFKALLN-------F 690
Query: 370 ERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQK 429
+ +KY+++ A+ + A G + + K +IN A+ + Q
Sbjct: 691 SKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKK----------DINGAIKFYEQ- 739
Query: 430 DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSY--ADIAVNSDRYN-PAA 486
++ + KD R++++A L Y M + + +A Y ++ V + + P
Sbjct: 740 ------QLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGE 793
Query: 487 LTNKGN---TVFANGDYEKAAEFYKEAL-----RNDSSCTEALY-NIGLTYEKLNRLDEA 537
G+ A G Y A + Y+E L D S +Y N+G+T +N ++EA
Sbjct: 794 CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEA 853
Query: 538 LDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYD 597
+ F + Q+A + +L N S + + LG+ Y+
Sbjct: 854 IGYFEQ-------------QLAMLQQLSGNES------------VLDRGRAYGNLGDCYE 888
Query: 598 REGDKSQAFQYY 609
GD +A +YY
Sbjct: 889 ALGDYEEAIKYY 900
Score = 46.6 bits (109), Expect = 9e-05
Identities = 82/402 (20%), Positives = 158/402 (39%), Gaps = 86/402 (21%)
Query: 203 LASQYSVNEMYAEAL--NTYQVIVKNKMFSNAGILKMN--MGNIYLKQRNYSKAIKFYRM 258
L + Y + + Y +AL +T ++ V ++ G + + + +Y+ Y+ A K Y
Sbjct: 760 LGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEE 819
Query: 259 ALDQVPSV-NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNL----------KA 307
LD + + + ++ N+G+T + +AI +E ++M L +A
Sbjct: 820 QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRA 879
Query: 308 GYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQM 367
NL CY A+GD E+ K +++ ++V ++ + + + + N H R M
Sbjct: 880 YGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKA--------YRGLGNGH-RAM 930
Query: 368 ERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLR 427
++A+ E ++ KA Y EL + + +
Sbjct: 931 GSLQQALV-------------CFEKRLVVAHELGEAFNKAQAYGELGS--------LHSQ 969
Query: 428 QKDYNQAVEILK-----VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRY 482
+Y QA+ L+ + KD ++S AA L +Y ++ A Y +
Sbjct: 970 LGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL------- 1022
Query: 483 NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALY-NIGLTYEKLNRLDEAL--- 538
D + A E N+ +C Y N+GLTYE L + A+
Sbjct: 1023 ----------------DLQIAEE------TNNPTCQGRAYGNLGLTYESLGTFERAVVYQ 1060
Query: 539 DCFLKLHAILRNSA--EVLY-QIANIYELMENPSQAIEWLMQ 577
+ L + A + + A V Y + + ++N SQA+ +L +
Sbjct: 1061 EQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQE 1102
Score = 43.5 bits (101), Expect = 8e-04
Identities = 104/541 (19%), Positives = 216/541 (39%), Gaps = 63/541 (11%)
Query: 202 NLASQYSVNEMYAEALNTYQ----VIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
NL S + Y EAL ++ + +K K A ++G++Y +Y A+ ++
Sbjct: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
Query: 258 MA-LDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYF 316
L S ++ + + N+G +I G + +A+ +E + +A +L Y
Sbjct: 339 QCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYS 398
Query: 317 AIGDREKMKKAFQKLITVP---LEIDED---KYISPSDDPHTNLVTEAIKN-DHLRQMER 369
+G ++ F K ++ LE+ ++ K I +++ + +Q
Sbjct: 399 NLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHE 458
Query: 370 ERKAMAEKYIMTSAKLIAPV---IETSFAAGYDWCVEVVKASQYV--ELANDLEINKAV- 423
++ +AE +A+ A I YD +++ K + EL++ +A
Sbjct: 459 QQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYG 518
Query: 424 ----TYLRQKDYNQAV-----EILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 474
Y Y+QAV E+ +E D +++ NL+ Y +A +
Sbjct: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
Query: 475 IAVNSDRY------NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTE------ALY 522
+N R AL+N GN + G+Y +AA +Y++ LR + +
Sbjct: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCH 638
Query: 523 NIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ------IANIYELMENPSQAIEW-- 574
N+G + L EA+ + + A+ ++ + L Q + ++ + N S+A E
Sbjct: 639 NLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQK 698
Query: 575 ----LMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYE----SYRYFPCNIEVIEW- 625
L Q ++ + L LG+++ + D + A ++Y + +++ +E +
Sbjct: 699 YLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYA 758
Query: 626 -LGAYYIDTQFWEKAIQYFERASLIQ------PTQVKWQLMVASCFRRSGNYQKALDTYK 678
LG Y Q ++KA+ Y + + P + + +A+ + G Y A Y+
Sbjct: 759 ALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYE 818
Query: 679 D 679
+
Sbjct: 819 E 819
Score = 32.3 bits (72), Expect = 1.8
Identities = 28/122 (22%), Positives = 52/122 (42%), Gaps = 2/122 (1%)
Query: 599 EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQL 658
+GD A Y E+ P N + A Y+ Q ++KA+ +A L+ P K
Sbjct: 71 DGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYF 130
Query: 659 MVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEK 718
+ G + AL + + P++++ L +V ++D+ E ++L+K
Sbjct: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE--PTYQQLQK 188
Query: 719 MK 720
MK
Sbjct: 189 MK 190
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 55.8 bits (133), Expect = 2e-07
Identities = 49/225 (21%), Positives = 94/225 (41%), Gaps = 15/225 (6%)
Query: 461 YMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEAL------RND 514
Y KDF A + D A D N +TN+ F GDY K E ++A+ R D
Sbjct: 236 YKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENRED 295
Query: 515 -SSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIE 573
+A IG +Y K + +A+ + N + ++ ++ + + + ++
Sbjct: 296 YRQIAKAYARIGNSYFKEEKYKDAIHFY--------NKSLAEHRTPDVLKKCQQAEKILK 347
Query: 574 WLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDT 633
++ + P G ++GD QA ++Y E+ + P + ++ A Y
Sbjct: 348 EQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKL 407
Query: 634 QFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 678
++ A++ E ++PT +K A+ +Y KA+D Y+
Sbjct: 408 LEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQ 452
Score = 39.3 bits (90), Expect = 0.015
Identities = 61/260 (23%), Positives = 106/260 (40%), Gaps = 22/260 (8%)
Query: 267 NKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMK 325
NK+ +K + +G + + A+ Y+ + P N+ N YF GD K +
Sbjct: 221 NKKQALK-EKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCR 279
Query: 326 KAFQKLITVPLEIDED-KYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAK 384
+ +K I V E ED + I+ + I N + + E + K Y + A+
Sbjct: 280 ELCEKAIEVGRENREDYRQIAKA--------YARIGNSYFK--EEKYKDAIHFYNKSLAE 329
Query: 385 LIAPVIETSFAAGYDWCVEVVKASQYVELAN-DL---EINKAVTYLRQKDYNQAVEILKV 440
P + +++K + + N DL E NK ++ DY QA++
Sbjct: 330 HRTPDVLKKCQQAE----KILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTE 385
Query: 441 LEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDY 500
K++ + + +N +A Y +F A + + + T K + A DY
Sbjct: 386 AIKRNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDY 444
Query: 501 EKAAEFYKEALRNDSSCTEA 520
KA + Y++AL DSSC EA
Sbjct: 445 TKAMDVYQKALDLDSSCKEA 464
Score = 30.4 bits (67), Expect = 7.0
Identities = 47/221 (21%), Positives = 75/221 (33%), Gaps = 42/221 (19%)
Query: 122 PASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQ 181
P P KK+ PE + L + + ++E + N DA +K+
Sbjct: 199 PPPPPPPKKETKPEPMEEDLPENKKQALKEKELGN-------------DAYKKKDFDTAL 245
Query: 182 REQVTTPENINLDLTY-----SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILK 236
+ E ++TY +V F E+ +A+ + + +
Sbjct: 246 KHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRE--NREDYRQIAKAY 303
Query: 237 MNMGNIYLKQRNYSKAIKFYRMAL--DQVPSVNK--QMRIKIM----------------- 275
+GN Y K+ Y AI FY +L + P V K Q KI+
Sbjct: 304 ARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEE 363
Query: 276 QNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICY 315
+N G Q G Y A+ Y + P + K N CY
Sbjct: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACY 404
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/320 (22%), Positives = 121/320 (37%), Gaps = 47/320 (14%)
Query: 199 VLFNLASQYSVNEMYAEALNTYQVIVKNK-----MFSNAGILKMNMGNIYLKQRNYSKAI 253
+L+NL N +AEAL+ Y++ + ++ + N GI+ MN G +R + K
Sbjct: 529 MLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
Query: 254 KFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTI 313
+ L P +K + N+G + + G Y +A++ Y+ + P A +L
Sbjct: 589 EIPDENLKD-PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLY- 646
Query: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
M +A+ +L +P + H + + K DH+ K
Sbjct: 647 --------NMMGEAYMRLSKLP------------EAEHWYMESLRSKTDHIPAHLTYGKL 686
Query: 374 MAEKYIMTSA-KLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYN 432
+A + A KL IE ++ K + Y+ L L +
Sbjct: 687 LALTGRKSEAEKLFLKAIE----------LDPTKGNCYMHYGQFL--------LEEARLI 728
Query: 433 QAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGN 492
+A E+ K + DS + N + + A Y D+A PAAL N G
Sbjct: 729 EAAEMAKKAAELDS-TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGA 787
Query: 493 TVFANGDYEKAAEFYKEALR 512
+ NG +KA Y AL+
Sbjct: 788 ILHLNGRLQKAEANYLRALQ 807
Score = 44.7 bits (104), Expect = 4e-04
Identities = 56/254 (22%), Positives = 96/254 (37%), Gaps = 18/254 (7%)
Query: 481 RYNPA-ALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALD 539
+ NPA A N GN + + +A Y+ AL S+ + LYN+GL ++ +R EAL
Sbjct: 489 KVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALH 548
Query: 540 CFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP----TDPQV------- 588
+ KL R + Y I + + ++ S IP DP
Sbjct: 549 -YYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTS 607
Query: 589 -LSKLGELYDREGDKSQAFQYYYESYRYFPCNI---EVIEWLGAYYIDTQFWEKAIQYFE 644
L LG+LY +G +A Y E+ + P + +G Y+ +A ++
Sbjct: 608 CLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667
Query: 645 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVEC-LRFLVRLCTDLGL 703
+ + + L +G +A + P C + + L + L
Sbjct: 668 ESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARL 727
Query: 704 KDAQEYARKLKRLE 717
+A E A+K L+
Sbjct: 728 IEAAEMAKKAAELD 741
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 6/229 (2%)
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEALRN--DSSCTEALYNI-GLTYEKLNRLDEALDCF 541
+ L N G G YE+A YKEA++ ++LYN+ G Y +L++L EA +
Sbjct: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
Query: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
++ + + L S+A + ++ + + PT G+ E
Sbjct: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEAR 726
Query: 602 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 661
+A + ++ +V+ E A +Y++ A+ ++P + +
Sbjct: 727 LIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLG 786
Query: 662 SCFRRSGNYQKALDTYKDTHRKFPENV---ECLRFLVRLCTDLGLKDAQ 707
+ +G QKA Y + P++V LR L + GLK ++
Sbjct: 787 AILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSK 835
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/325 (22%), Positives = 128/325 (39%), Gaps = 59/325 (18%)
Query: 421 KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGK-DFAQA--------SS 471
KA ++ DY+ + E ++ L++ L +L Y K F +A SS
Sbjct: 356 KAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSS 415
Query: 472 YADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTY--- 528
Y D+A + + AL + F DY +A + ++ AL D+ E Y +GLTY
Sbjct: 416 YPDLA---EVHALEALIH-----FTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFM 467
Query: 529 --EKLNRLDEALDCFLKLHAILRNSAEVLYQIANIY------------------ELMENP 568
E +AL FLK + +V + + Y EL +
Sbjct: 468 GEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTD 527
Query: 569 SQA----------IEWLMQVVSVIPTDPQVLS---------KLGELYDREGDKSQAFQYY 609
+++ +E + ++++ T Q S + G Y + G SQA
Sbjct: 528 AESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADL 587
Query: 610 YESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGN 669
+ R P + E LG Y+ + A++ F +AS + P + VA+ + G
Sbjct: 588 QAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGK 647
Query: 670 YQKALDTYKDTHRKFPENVECLRFL 694
Y++A+ Y+ +K + V L+ L
Sbjct: 648 YKEAVAQYQMIIKKKEDYVPALKGL 672
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/319 (23%), Positives = 127/319 (39%), Gaps = 54/319 (16%)
Query: 240 GNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIM 299
GN Y +++Y++A +Y A+D P N T + G++ +A+ + +
Sbjct: 35 GNAYYAKKDYNEAYNYYTKAIDMCPK-----NASYYGNRAATLMMLGRFREALGDAQQSV 89
Query: 300 SMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEA 358
+ + G+ C+ ++G+ ++FQ+ LE+D + + + N V
Sbjct: 90 RLDDSFVRGHLREGKCHLSLGNAMAACRSFQR----ALELDHKNAQAQQEFKNANAV--- 142
Query: 359 IKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLE 418
ME E+ A + K++ +C++ +A ++ + +
Sbjct: 143 --------MEYEKIAETDFEKRDFRKVV-------------FCMD--RALEFAPACHRFK 179
Query: 419 INKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMG------KDFAQASSY 472
I KA Y +A + + + DS A LYY + F QA
Sbjct: 180 ILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRM 239
Query: 473 A---DIAVNSDRYNPAALTNK---GNTVFANGDYEKAAEFYKEAL---RNDSSCTEALY- 522
A + A + R N AL K GN F G+Y+ A E Y EAL N+ LY
Sbjct: 240 APDHEKACIACR-NAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYC 298
Query: 523 NIGLTYEKLNRLDEAL-DC 540
N G KL +LD+A+ DC
Sbjct: 299 NRGTVNSKLRKLDDAIEDC 317
Score = 32.0 bits (71), Expect = 2.4
Identities = 24/128 (18%), Positives = 54/128 (42%)
Query: 439 KVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANG 498
++L+ ++++ ++ YY KD+ +A +Y A++ N + N+ T+ G
Sbjct: 17 ELLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLG 76
Query: 499 DYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQI 558
+ +A ++++R D S G + L A F + + +A+ +
Sbjct: 77 RFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEF 136
Query: 559 ANIYELME 566
N +ME
Sbjct: 137 KNANAVME 144
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/176 (22%), Positives = 78/176 (44%), Gaps = 20/176 (11%)
Query: 418 EINKAVTYL--RQKDYNQAVEILKVLEKKDSRVKSAAAT-----------NLSALYYMGK 464
E+++ +T R + + Q EIL L + + V + LY++ +
Sbjct: 204 ELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISE 263
Query: 465 DFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNI 524
D+A A ++ ++ P A+ KG T F G ++A E +KEAL+ +A ++
Sbjct: 264 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 323
Query: 525 GLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQAIE 573
G Y +L + A + F K + +N + +LY ++ E ++N + ++
Sbjct: 324 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ 379
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 50.8 bits (120), Expect = 5e-06
Identities = 30/122 (24%), Positives = 60/122 (49%), Gaps = 7/122 (5%)
Query: 459 LYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 518
LY++ +D+A A ++ ++ P A+ KG T F G ++A E +KEAL+
Sbjct: 205 LYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFI 264
Query: 519 EALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQA 571
+A ++G Y +L + A + F K + +N + +LY ++ E ++N +
Sbjct: 265 DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
Query: 572 IE 573
++
Sbjct: 325 LQ 326
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 8/184 (4%)
Query: 507 YKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELME 566
Y EA+R+ S+ + L +G E +N L +A+ L+ SA + +Y + E
Sbjct: 159 YDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQ--------LQPSARLYRHRGTLYFISE 210
Query: 567 NPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWL 626
+ + A E Q + + P + G + G +A + + E+ + I+ + L
Sbjct: 211 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 270
Query: 627 GAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPE 686
G Y + +E A + F++A L+ V+ + G+ Q+AL +K + P
Sbjct: 271 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
Query: 687 NVEC 690
N C
Sbjct: 331 NEVC 334
Score = 32.7 bits (73), Expect = 1.4
Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 1/138 (0%)
Query: 489 NKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAIL 548
++G F + DY A E ++++L + + A+ GLT+ L EA++ F +
Sbjct: 201 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 260
Query: 549 RNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQY 608
+ + + Y + N A E + + + Q L G + G +A +
Sbjct: 261 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 320
Query: 609 YYESYRYFPCNIEVIEWL 626
+ + P N EV +++
Sbjct: 321 FKRCLQLEPYN-EVCQYM 337
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/250 (18%), Positives = 95/250 (38%), Gaps = 1/250 (0%)
Query: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Y +Y QA I + + ++ + L+++ KD A + D+ + D+ +P
Sbjct: 515 YFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT-DMDKNSP 573
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL 544
A GN +++ A +F++ A++ D + A +G + LD+AL CF
Sbjct: 574 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 633
Query: 545 HAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 604
+ Y + IY E S A + + + P +L +G + +
Sbjct: 634 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 693
Query: 605 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 664
A ++ P N + + ++ A+Q E I P + ++ +
Sbjct: 694 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 753
Query: 665 RRSGNYQKAL 674
++ G AL
Sbjct: 754 KKLGQTHLAL 763
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 2/135 (1%)
Query: 475 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 534
I VN YN A G + + A +++AL + + L +IG+ L +
Sbjct: 634 IRVNPRHYN--AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691
Query: 535 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGE 594
++ALD K I + + A++ E A++ L ++ ++P + V +G+
Sbjct: 692 EKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGK 751
Query: 595 LYDREGDKSQAFQYY 609
+Y + G A +
Sbjct: 752 VYKKLGQTHLALMNF 766
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/250 (18%), Positives = 95/250 (38%), Gaps = 1/250 (0%)
Query: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Y +Y QA I + + ++ + L+++ KD A + D+ + D+ +P
Sbjct: 509 YFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT-DMDKNSP 567
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKL 544
A GN +++ A +F++ A++ D + A +G + LD+AL CF
Sbjct: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
Query: 545 HAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQ 604
+ Y + IY E S A + + + P +L +G + +
Sbjct: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
Query: 605 AFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCF 664
A ++ P N + + ++ A+Q E I P + ++ +
Sbjct: 688 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 747
Query: 665 RRSGNYQKAL 674
++ G AL
Sbjct: 748 KKLGQTHLAL 757
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 2/135 (1%)
Query: 475 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 534
I VN YN A G + + A +++AL + + L +IG+ L +
Sbjct: 628 IRVNPRHYN--AWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
Query: 535 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGE 594
++ALD K I + + A++ E A++ L ++ ++P + V +G+
Sbjct: 686 EKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGK 745
Query: 595 LYDREGDKSQAFQYY 609
+Y + G A +
Sbjct: 746 VYKKLGQTHLALMNF 760
>gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]
Length = 1121
Score = 48.1 bits (113), Expect = 3e-05
Identities = 42/174 (24%), Positives = 76/174 (43%), Gaps = 4/174 (2%)
Query: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
S E +A + L +N ++A E+L Q + +P V G LY G+ S+A Y
Sbjct: 928 SCEYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYE 987
Query: 611 ESYRYFPCNIE---VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRS 667
+ + E + LG Y++ + +EKA + + +A P+ + W + +C+R
Sbjct: 988 RTISFVVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWLGLGIACYRLE 1047
Query: 668 GNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKE 721
+A D + + N E +L +C +G + E A K K+K+
Sbjct: 1048 -ELTEAEDALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMIKLKLKD 1100
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/188 (21%), Positives = 73/188 (38%), Gaps = 38/188 (20%)
Query: 456 LSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANG----------------- 498
L+ + + K+FA+A Y A D NP KG+ F +G
Sbjct: 935 LAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTISFVV 994
Query: 499 --------------------DYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL 538
+YEKA + Y +A + SC L +G+ +L L EA
Sbjct: 995 DASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWL-GLGIACYRLEELTEAE 1053
Query: 539 DCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 598
D + +A+ +AEV +A + + +A + ++ + D +L+++ L +
Sbjct: 1054 DALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMIKLKLKDEALLAEIHTLQET 1113
Query: 599 EGDKSQAF 606
G + +F
Sbjct: 1114 VGFGNPSF 1121
Score = 31.2 bits (69), Expect = 4.1
Identities = 25/116 (21%), Positives = 50/116 (43%)
Query: 497 NGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLY 556
N ++E AA +YKE L + + + G +A +CF K ++ ++ L
Sbjct: 648 NENFEMAAAYYKERLVREPQNLDHWLDYGAFCLLTEDNIKAQECFQKALSLNQSHIHSLL 707
Query: 557 QIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYES 612
+ L+EN QA + + PT+ + LG Y+ + + + ++E+
Sbjct: 708 LCGVLAVLLENYEQAEIFFEDATCLEPTNVVAWTLLGLYYEIQNNDIRMEMAFHEA 763
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 9e-05
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 45.1 bits (105), Expect = 3e-04
Identities = 62/297 (20%), Positives = 111/297 (37%), Gaps = 22/297 (7%)
Query: 420 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 475
+KA+ L +N+A +L ++ K R K A AL ASS++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DASSHSDK 1186
Query: 476 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 531
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATTISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKI 1246
Query: 532 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 588
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 589 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 645
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 646 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 702
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/436 (20%), Positives = 160/436 (36%), Gaps = 80/436 (18%)
Query: 207 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 258
Y++ Y E N TY++ + + M N+ I N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258
Query: 259 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 317
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 318 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 374
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 375 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 425
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 426 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 453
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 454 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 513
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 514 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 566
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 567 NPSQAIEWLMQVVSVI 582
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 9e-05
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 42.7 bits (99), Expect = 0.001
Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%)
Query: 420 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 475
+KA+ L +N+A +L ++ K R K A AL A S++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186
Query: 476 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 531
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKI 1246
Query: 532 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 588
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 589 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 645
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 646 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 702
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/436 (20%), Positives = 160/436 (36%), Gaps = 80/436 (18%)
Query: 207 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 258
Y++ Y E N TY++ + + M N+ I N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258
Query: 259 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 317
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 318 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 374
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 375 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 425
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 426 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 453
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 454 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 513
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 514 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 566
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 567 NPSQAIEWLMQVVSVI 582
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 46.6 bits (109), Expect = 9e-05
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)
Query: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
+Y A +G G + A + + + A ++ L Y ++++EALD
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
+H +N+ E A IY ++ + AI Q + PTD + + GE+Y+
Sbjct: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
Query: 601 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+K A + + Y P + + G +Y + + W AI+ F
Sbjct: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
Score = 43.5 bits (101), Expect = 8e-04
Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%)
Query: 420 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 475
+KA+ L +N+A +L ++ K R K A AL A S++D
Sbjct: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186
Query: 476 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 531
++ + L N G G+ Y+ A A+ D + A YN L Y K+
Sbjct: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKI 1246
Query: 532 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 588
L AL + L L A IY + A+E Q + T+ +
Sbjct: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
Query: 589 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 645
+ R + +A ++ + + PC ++ G Y++ + ++A + F +
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 646 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 702
A I P +K ++ + G +QKA + + P+N +C +G
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Score = 40.0 bits (92), Expect = 0.009
Identities = 87/436 (19%), Positives = 159/436 (36%), Gaps = 80/436 (18%)
Query: 207 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 258
Y++ Y E N TY++ + + M N+ N Y K R A+ Y +
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGI 1258
Query: 259 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 317
L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+
Sbjct: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
Query: 318 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 374
I + E+ F T L+I+ D Y+ N ++ E
Sbjct: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
Query: 375 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 425
A+K + + + I+ + GY+ + KA + +A D + + Y
Sbjct: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
Query: 426 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 453
+D N A++I E K + +K S A
Sbjct: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
Query: 454 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 513
N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
Query: 514 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 566
+N Y L + + A + K ++ N A+V +I I E M
Sbjct: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
Query: 567 NPSQAIEWLMQVVSVI 582
+ +QA++ L SVI
Sbjct: 1600 DYNQALD-LEDYASVI 1614
Score = 36.2 bits (82), Expect = 0.13
Identities = 64/353 (18%), Positives = 132/353 (37%), Gaps = 54/353 (15%)
Query: 309 YNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQME 368
YNL +CY G+ + K +T + +D++ Y T A+ +R+++
Sbjct: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY--------TAFYNRALCYTKIRELQ 1250
Query: 369 RERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQ 428
+T ++ + T E VK + + +N+ + Y+
Sbjct: 1251 ---------MALTDYGIVLLLDAT----------ETVKLNTF--------LNRGLIYVEL 1283
Query: 429 KDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALT 488
Y A+E K SR + + ++ +F +A ++ A+ + A
Sbjct: 1284 GQYGFALEDFK-QAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
Query: 489 NKGNTVFANGDYE---KAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDE-------AL 538
+GN+ G E +A + + +AL + + +A + G + + + A+
Sbjct: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
Query: 539 DCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 598
D K + A V Q+ N + M++ + A++ I T + L+ G +++
Sbjct: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK--------ISTTAEFLTNRGVIHEF 1454
Query: 599 EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP 651
G K A + Y ++ P G Y + + +A YF +A P
Sbjct: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/292 (20%), Positives = 124/292 (42%), Gaps = 21/292 (7%)
Query: 413 LANDLEINKAVTYLRQKDYNQAVEILKVLE-----KKDSRVKSAAATNLSALYYMGKDFA 467
L N+ +A+ Y Q + Q +I + K +R K A + + A M +
Sbjct: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
Query: 468 QASSYADIAVNSDRYNPAALTNKGNTVFANGD-YEKAAEFYKEALRNDSSCTEALYNIGL 526
A IA N + N N + AN E+A + Y++A+ +A + G
Sbjct: 516 GKKYAARIAPN----HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGE 571
Query: 527 TYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP--- 583
K+N+ +A + +LK + RN+A++ Y +A ++ ++ P++A++ + + + P
Sbjct: 572 LLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
Query: 584 ----TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKA 639
V+ + GE+ R + + Y E P + LG +D + +A
Sbjct: 632 LALFNSAIVMQESGEVKLRPEARKRLLSYINEE----PLDANGYFNLGMLAMDDKKDNEA 687
Query: 640 IQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 691
+ ++A +Q +A + ++ KAL ++ R +P++++ L
Sbjct: 688 EIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGL 739
Score = 44.7 bits (104), Expect = 4e-04
Identities = 40/191 (20%), Positives = 81/191 (42%), Gaps = 15/191 (7%)
Query: 476 AVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLD 535
A+ ++ N N G+ + ++E+A +++ +A A N+G TY+ LNR
Sbjct: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
Query: 536 EALDCFLKLHAIL--------------RNSAEVLYQIANIYELMENP-SQAIEWLMQVVS 580
EA + ++ +++ N V +AN+ E+ +A + Q +S
Sbjct: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAIS 557
Query: 581 VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAI 640
+ P Q GEL + +A + Y ++ N ++ L +I+ + +A+
Sbjct: 558 MRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEAL 617
Query: 641 QYFERASLIQP 651
+ F RA + P
Sbjct: 618 KNFNRALELNP 628
Score = 32.3 bits (72), Expect = 1.8
Identities = 21/97 (21%), Positives = 39/97 (40%)
Query: 487 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHA 546
LT+ T N D+E + AL+ + + + N+G E + AL FL+
Sbjct: 415 LTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATH 474
Query: 547 ILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583
+ + + Y+ + +A E M S++P
Sbjct: 475 VQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMP 511
Score = 32.3 bits (72), Expect = 1.8
Identities = 74/397 (18%), Positives = 148/397 (37%), Gaps = 40/397 (10%)
Query: 227 KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAG 286
K+ N L N+G+ ++N+ +A+K++ A P I N+G T+
Sbjct: 440 KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPD-----DIGAHMNVGRTYKNLN 494
Query: 287 QYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISP 346
+ +A SY S+ P + G KK ++ L + YI+
Sbjct: 495 RTKEAEESYMMAKSLMPQIIPG----------------KKYAARIAPNHLNV----YINL 534
Query: 347 SDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVK 406
++ N + RQ R + YI L+ Y +K
Sbjct: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY------LK 588
Query: 407 ASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMG--K 464
A + DL N A+ ++ K+ N+A++ + + + K A + + G K
Sbjct: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648
Query: 465 DFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNI 524
+A +N + + N G + +A + K+A++ + AL+N+
Sbjct: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
Query: 525 GLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI----EWLMQVVS 580
L Y + + +AL L +LR + + + +++ N + I + +++
Sbjct: 709 ALLYSQTAKELKALPI---LEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILE 765
Query: 581 VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFP 617
+ P++ Q L +Y E D +A + E+ P
Sbjct: 766 MDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 232 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 290
Query: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 291 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 350
Query: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
+ N ++ LG Q ++ + FERA
Sbjct: 351 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 386
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 524 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 231 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
Query: 584 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
Query: 644 ER 645
R
Sbjct: 350 RR 351
Score = 37.0 bits (84), Expect = 0.075
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 198 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 350
Query: 258 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 313
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 351 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 405
Query: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
IGD + F+ + + N EA N + +M +
Sbjct: 406 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 448
Query: 374 MAEKYIMTSAKLIAPVIETSF 394
A + T++ L + E F
Sbjct: 449 QARALLQTASSLAPHMYEPHF 469
Score = 34.7 bits (78), Expect = 0.37
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 302 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 360
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 361 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 420
Query: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 421 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 480
Query: 602 KSQAFQYYYESYRYFPCNIE 621
+++ +S FP +++
Sbjct: 481 LQRSYVAAQKSEAAFPDHVD 500
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 192 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 250
Query: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 251 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 310
Query: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
+ N ++ LG Q ++ + FERA
Sbjct: 311 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 346
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 524 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 191 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 249
Query: 584 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 250 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 309
Query: 644 ER 645
R
Sbjct: 310 RR 311
Score = 37.0 bits (84), Expect = 0.075
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 198 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 253 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 310
Query: 258 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 313
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 311 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 365
Query: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
IGD + F+ + + N EA N + +M +
Sbjct: 366 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 408
Query: 374 MAEKYIMTSAKLIAPVIETSF 394
A + T++ L + E F
Sbjct: 409 QARALLQTASSLAPHMYEPHF 429
Score = 34.7 bits (78), Expect = 0.37
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 262 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 320
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 321 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 380
Query: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 381 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 440
Query: 602 KSQAFQYYYESYRYFPCNIE 621
+++ +S FP +++
Sbjct: 441 LQRSYVAAQKSEAAFPDHVD 460
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRN 550
G + G Y +A + +K AL+ LY + Y L++ AL+ F +
Sbjct: 222 GKCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPG 280
Query: 551 SAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYY 610
+L IA IYE M N S A E+ +V+ T + ++ +G + A ++Y
Sbjct: 281 EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYR 340
Query: 611 ESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
+ N ++ LG Q ++ + FERA
Sbjct: 341 RLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERA 376
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 524 IGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP 583
IG Y +L EA F K + + +A +Y ++ P A+ Q + P
Sbjct: 221 IGKCYYRLGMYREAEKQF-KSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
Query: 584 TDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 643
+ +L + +Y+ + S A +YY E + ++E I +G+ + + E A++++
Sbjct: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
Query: 644 ER 645
R
Sbjct: 340 RR 341
Score = 37.0 bits (84), Expect = 0.075
Identities = 44/201 (21%), Positives = 75/201 (37%), Gaps = 28/201 (13%)
Query: 198 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYR 257
++L +A Y + A Y+ ++K I + + Y Q A++FYR
Sbjct: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI--ALRFYR 340
Query: 258 MALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAG----YNLTI 313
L Q+ N Q+ N+G+ A QY + S+E +S+A N + YNL
Sbjct: 341 RLL-QMGIYNGQL----FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGH 395
Query: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
IGD + F+ + + N EA N + +M +
Sbjct: 396 VAVGIGDTNLAHQCFRLALV-----------------NNNNHAEAYNNLAVLEMRKGHVE 438
Query: 374 MAEKYIMTSAKLIAPVIETSF 394
A + T++ L + E F
Sbjct: 439 QARALLQTASSLAPHMYEPHF 459
Score = 34.7 bits (78), Expect = 0.37
Identities = 41/200 (20%), Positives = 72/200 (36%), Gaps = 4/200 (2%)
Query: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Y + + A E K + K+D+ A A S +Y + Y + + YN
Sbjct: 292 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL-LQMGIYNG 350
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEAL---RNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
N G F Y+ ++ AL N+ + YN+G + + A CF
Sbjct: 351 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 410
Query: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
N AE +A + + QA L S+ P + + D+ GD
Sbjct: 411 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 470
Query: 602 KSQAFQYYYESYRYFPCNIE 621
+++ +S FP +++
Sbjct: 471 LQRSYVAAQKSEAAFPDHVD 490
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 15/125 (12%)
Query: 486 ALTNKGNTVFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALD 539
A +N GN G++E A+E+YK+ L++ + ++ Y++G TY L ++A+D
Sbjct: 244 AYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAID 303
Query: 540 CFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 593
LK AI + + + N Y + N QA+ + + + + +V K G
Sbjct: 304 YHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI---SREVGDKSG 360
Query: 594 ELYDR 598
EL R
Sbjct: 361 ELTAR 365
Score = 33.9 bits (76), Expect = 0.63
Identities = 62/297 (20%), Positives = 113/297 (38%), Gaps = 39/297 (13%)
Query: 239 MGNIYLKQRNYSKAIKFYRMALDQVPSVNKQM-RIKIMQNIGVTFIQAGQYSDAINSYEH 297
+GN Y +Y+KA++++ L ++ Q+ K N+G T G + +AI +
Sbjct: 68 LGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQR 127
Query: 298 IMSMAPNL-------KAGYNLTICYFAIGDREKMKKAF-----QKLITVPLEIDEDKYIS 345
+ ++ L +A YNL Y A G K+F Q + P E+ D +
Sbjct: 128 HLDISRELNDKVGEARALYNLGNVYHAKG------KSFGCPGPQDVGEFPEEV-RDALQA 180
Query: 346 PSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVV 405
D NL D Q Y++ + + E ++ +
Sbjct: 181 AVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAA 240
Query: 406 KASQYVELANDLEINKAVTYLRQKDYNQAVE-----ILKVLEKKDSRVKSAAATNLSALY 460
+ Y L N Y+ ++ A E +L + KD V++ + +L Y
Sbjct: 241 ERRAYSNLGN--------AYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTY 292
Query: 461 YMGKDFAQASSY-----ADIAVNSDRYNPA-ALTNKGNTVFANGDYEKAAEFYKEAL 511
+ +D+ +A Y A +DR A + GN A G++++A F ++ L
Sbjct: 293 TLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349
Score = 32.7 bits (73), Expect = 1.4
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 12/90 (13%)
Query: 485 AALTNKGNTVFANGDYEKAAEFYKEALR------NDSSCTEALYNIGLTYEKLNRLDEAL 538
A + GN F DY KA E++ L + +A N+G T + L DEA+
Sbjct: 63 AIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAI 122
Query: 539 DCFLKLHAILR------NSAEVLYQIANIY 562
C + I R A LY + N+Y
Sbjct: 123 VCCQRHLDISRELNDKVGEARALYNLGNVY 152
>gi|6912398 general transcription factor IIIC, polypeptide 3, 102kDa
[Homo sapiens]
Length = 886
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/120 (22%), Positives = 57/120 (47%)
Query: 559 ANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPC 618
ANI +AI M+++ P + S L +Y+ +GD ++ Q+ + P
Sbjct: 156 ANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPS 215
Query: 619 NIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 678
+ E L ++ ++AI + +A +PT V++ +S + + G+++ A+D Y+
Sbjct: 216 DTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYR 275
Score = 39.7 bits (91), Expect = 0.012
Identities = 29/123 (23%), Positives = 52/123 (42%)
Query: 487 LTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHA 546
L + N FA G+ E+A E +R E + + YE ++++L L
Sbjct: 152 LMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAH 211
Query: 547 ILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAF 606
+ + E ++A + +N QAI + + PT+ + L + LY++ GD A
Sbjct: 212 LNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAM 271
Query: 607 QYY 609
Y
Sbjct: 272 DGY 274
Score = 35.0 bits (79), Expect = 0.28
Identities = 29/151 (19%), Positives = 69/151 (45%), Gaps = 7/151 (4%)
Query: 498 GDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQ 557
GD EK+ +F A + S TE + + + + +A+ C+ K + L++
Sbjct: 197 GDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWE 256
Query: 558 IANIYELMENPSQAIEWLMQVVSVI-PTD----PQVLSKLGELYDREGDKSQAFQYYYES 612
+++YE M + A++ ++++++ P+D Q+ + + Y D + A E+
Sbjct: 257 RSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEA 316
Query: 613 YRYFP--CNIEVIEWLGAYYIDTQFWEKAIQ 641
+ ++E + YI + ++KA++
Sbjct: 317 FSKHQGLVSMEDVNIAAELYISNKQYDKALE 347
>gi|6912630 interferon-induced protein with tetratricopeptide
repeats 5 [Homo sapiens]
Length = 482
Score = 41.2 bits (95), Expect = 0.004
Identities = 79/347 (22%), Positives = 139/347 (40%), Gaps = 41/347 (11%)
Query: 288 YSDAINSYEHIMSMAPN---LKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYI 344
Y A ++E + + P+ GY +T+ DRE K+F PL K +
Sbjct: 156 YQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFS---LGPLR----KAV 208
Query: 345 SPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIA--PVIETSFAAGYDWCV 402
+ + D V A+K L+ + E A EKYI I+ P + A Y
Sbjct: 209 TLNPDNSYIKVFLALK---LQDVHAE--AEGEKYIEEILDQISSQPYVLRYAAKFYRRKN 263
Query: 403 EVVKASQYVELANDLEINKAVTYLR-QKDYNQAVEILKVLEKKDSRVKSAAATNLSALYY 461
KA + ++ A LE+ ++L Q +++++ + +R K + L
Sbjct: 264 SWNKALELLKKA--LEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDEL-- 319
Query: 462 MGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEAL 521
+ A + A+ D A T+ N G Y A + +++ALR ++ +
Sbjct: 320 ----ISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHK 375
Query: 522 YNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLY----QIANIYELMENPSQAIEWLM- 576
+ I Y + F + H N+A Y ++ + L + A++ L
Sbjct: 376 HQIHYHYGR----------FQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLST 425
Query: 577 QVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVI 623
+ + D Q LS LG +Y EG+K QA +YY ++ + P N E +
Sbjct: 426 KRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFL 472
>gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Homo
sapiens]
Length = 864
Score = 40.4 bits (93), Expect = 0.007
Identities = 56/288 (19%), Positives = 117/288 (40%), Gaps = 37/288 (12%)
Query: 461 YMGKDFAQASSYADIAVNSDRY--NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 518
Y K + + + +++ ++ + L KG T+ G E+A EF ++ LRND
Sbjct: 21 YEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSH 80
Query: 519 EALYNIGLTYEKLNRLDEALDCF---LKLH----AILRNSAEVLYQIANI-------YEL 564
+ GL + DEA+ C+ LKL ILR+ + + Q+ ++ Y+L
Sbjct: 81 VCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQL 140
Query: 565 ME-NPSQAIEWLMQVVS--VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIE 621
++ P+Q W+ ++ ++ L L E + Y Y E
Sbjct: 141 LQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYS---------E 191
Query: 622 VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTH 681
+I + + ++++++ E ++ + + + G ++A + +K+
Sbjct: 192 LILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI 251
Query: 682 RKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKS 729
+ EN C GL+ A + + +RL+ +EI +Q K+
Sbjct: 252 DRNAEN---------WCYYEGLEKALQISTLEERLQIYEEISKQHPKA 290
Score = 30.4 bits (67), Expect = 7.0
Identities = 67/325 (20%), Positives = 128/325 (39%), Gaps = 34/325 (10%)
Query: 419 INKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALY-YMGKDFAQASSYADIAV 477
I A+ Y KDY+ A+++L+ + + S L Y + +A +
Sbjct: 152 IGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREADLLQESLE 211
Query: 478 NSDRYNPAALTN------KGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE-K 530
+ + Y KG + G ++A+E +K + D + Y GL +
Sbjct: 212 HIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI--DRNAENWCYYEGLEKALQ 269
Query: 531 LNRLDEALDCFLKLH-----AIL-RNSAEVLYQIANIYELME-----NPSQAIEWLMQVV 579
++ L+E L + ++ AI R L ELM+ N S+ L +
Sbjct: 270 ISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTL 329
Query: 580 SVIPTDPQVLSKLGEL---YDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQF- 635
+ + + +S + EL Y+ F Y + P + +++ A + D
Sbjct: 330 KSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPPTTLLWVQYFLAQHFDKLGQ 389
Query: 636 WEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKA---LDTYK--DTHRKFPENVEC 690
+ A+ Y A PT ++ M A ++ GN ++A +D + DT +F N +C
Sbjct: 390 YSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDEAQSLDTADRF-INSKC 448
Query: 691 LRFLVRLCTDLGLKDAQEYARKLKR 715
++++R +K+A+E K R
Sbjct: 449 AKYMLRANM---IKEAEEMCSKFTR 470
>gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [Homo
sapiens]
Length = 429
Score = 40.4 bits (93), Expect = 0.007
Identities = 56/288 (19%), Positives = 117/288 (40%), Gaps = 37/288 (12%)
Query: 461 YMGKDFAQASSYADIAVNSDRY--NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 518
Y K + + + +++ ++ + L KG T+ G E+A EF ++ LRND
Sbjct: 21 YEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSH 80
Query: 519 EALYNIGLTYEKLNRLDEALDCF---LKLH----AILRNSAEVLYQIANI-------YEL 564
+ GL + DEA+ C+ LKL ILR+ + + Q+ ++ Y+L
Sbjct: 81 VCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQL 140
Query: 565 ME-NPSQAIEWLMQVVS--VIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIE 621
++ P+Q W+ ++ ++ L L E + Y Y E
Sbjct: 141 LQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYS---------E 191
Query: 622 VIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTH 681
+I + + ++++++ E ++ + + + G ++A + +K+
Sbjct: 192 LILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLI 251
Query: 682 RKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKS 729
+ EN C GL+ A + + +RL+ +EI +Q K+
Sbjct: 252 DRNAEN---------WCYYEGLEKALQISTLEERLQIYEEISKQHPKA 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,413,525
Number of Sequences: 37866
Number of extensions: 1204801
Number of successful extensions: 5315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 4728
Number of HSP's gapped (non-prelim): 553
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.