Guide to the Human Genome
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Search of human proteins with 27544941

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27544941 myosin IF [Homo sapiens]
         (1098 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27544941 myosin IF [Homo sapiens]                                 2223   0.0  
gi|55956916 myosin IE [Homo sapiens]                                 1605   0.0  
gi|124494247 myosin IC isoform b [Homo sapiens]                       612   e-175
gi|124494238 myosin IC isoform a [Homo sapiens]                       612   e-175
gi|124494240 myosin IC isoform c [Homo sapiens]                       612   e-175
gi|194328685 myosin IB isoform 1 [Homo sapiens]                       611   e-174
gi|44889481 myosin IB isoform 2 [Homo sapiens]                        611   e-174
gi|240120050 myosin IB isoform 1 [Homo sapiens]                       611   e-174
gi|254028267 myosin 1H [Homo sapiens]                                 596   e-170
gi|4885503 myosin IA [Homo sapiens]                                   571   e-162
gi|51100974 myosin ID [Homo sapiens]                                  539   e-153
gi|239582755 myosin IG [Homo sapiens]                                 507   e-143
gi|189083802 myosin VIIA isoform 2 [Homo sapiens]                     481   e-135
gi|189083800 myosin VIIA isoform 3 [Homo sapiens]                     481   e-135
gi|189083798 myosin VIIA isoform 1 [Homo sapiens]                     481   e-135
gi|153945715 myosin VC [Homo sapiens]                                 473   e-133
gi|122937512 myosin VIIB [Homo sapiens]                               473   e-133
gi|118402590 myosin XV [Homo sapiens]                                 463   e-130
gi|154354979 myosin X [Homo sapiens]                                  458   e-128
gi|122937345 myosin VB [Homo sapiens]                                 457   e-128
gi|215982794 myosin VA isoform 2 [Homo sapiens]                       455   e-128
gi|215982791 myosin VA isoform 1 [Homo sapiens]                       455   e-128
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    433   e-121
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   431   e-120
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   428   e-119
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   420   e-117
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   420   e-117
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      419   e-117
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          419   e-117
gi|92859701 myosin VI [Homo sapiens]                                  419   e-116

>gi|27544941 myosin IF [Homo sapiens]
          Length = 1098

 Score = 2223 bits (5761), Expect = 0.0
 Identities = 1098/1098 (100%), Positives = 1098/1098 (100%)

Query: 1    MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 60
            MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF
Sbjct: 1    MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 60

Query: 61   KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 120
            KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA
Sbjct: 61   KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 120

Query: 121  KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 180
            KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG
Sbjct: 121  KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 180

Query: 181  EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 240
            EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD
Sbjct: 181  EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 240

Query: 241  TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 300
            TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV
Sbjct: 241  TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 300

Query: 301  DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 360
            DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR
Sbjct: 301  DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 360

Query: 361  LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 420
            LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK
Sbjct: 361  LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 420

Query: 421  AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 480
            AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL
Sbjct: 421  AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 480

Query: 481  QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 540
            QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL
Sbjct: 481  QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 540

Query: 541  RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 600
            RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR
Sbjct: 541  RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 600

Query: 601  VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV 660
            VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV
Sbjct: 601  VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV 660

Query: 661  NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA 720
            NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA
Sbjct: 661  NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA 720

Query: 721  SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR 780
            SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR
Sbjct: 721  SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR 780

Query: 781  DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD 840
            DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD
Sbjct: 781  DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD 840

Query: 841  SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD 900
            SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD
Sbjct: 841  SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD 900

Query: 901  LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP 960
            LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP
Sbjct: 901  LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP 960

Query: 961  SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR 1020
            SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR
Sbjct: 961  SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR 1020

Query: 1021 KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK 1080
            KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK
Sbjct: 1021 KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK 1080

Query: 1081 GRLHGQEGLFPGNYVEKI 1098
            GRLHGQEGLFPGNYVEKI
Sbjct: 1081 GRLHGQEGLFPGNYVEKI 1098


>gi|55956916 myosin IE [Homo sapiens]
          Length = 1108

 Score = 1605 bits (4157), Expect = 0.0
 Identities = 796/1116 (71%), Positives = 933/1116 (83%), Gaps = 26/1116 (2%)

Query: 1    MGSKE--RFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVN 58
            MGSK   ++HWQSHNVK SGVDDMVLL +ITE++I  NL+KR+MDDYIFTYIGSVLISVN
Sbjct: 1    MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVN 60

Query: 59   PFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTV 118
            PFKQMPYF ++EI++YQGAAQYENPPHIYAL DNMYRNM+ID ENQCVIISGESGAGKTV
Sbjct: 61   PFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTV 120

Query: 119  AAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSR 178
            AAKYIM YIS+VSGGG KVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFS 
Sbjct: 121  AAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSP 180

Query: 179  GGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQ 238
            GGEPDGGKISNFLLEKSRVVM+N  ER+FHI+YQL+EGAS EQ+ +LG+ + DYYYYL+ 
Sbjct: 181  GGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSL 240

Query: 239  SDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVE 298
            S +Y+VD  DDR +F ETL AM VIGI    Q LVLQ+VAGILHLGNISF E GNYA VE
Sbjct: 241  SGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVE 300

Query: 299  SVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLY 358
            S + LAFPAYLLGI+  RL+EKLTSR+MDS+WGG+SESI+VTLNVEQA YTRDALAK L+
Sbjct: 301  SEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALH 360

Query: 359  ARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 418
            AR+FDFLV++IN+AM+K  EEY+IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT
Sbjct: 361  ARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 420

Query: 419  LKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT 478
            LKAEQEEYVQEGIRWTPI+YFNNK+VCDLIENK++PPGIMS+LDDVCATMHA G GADQT
Sbjct: 421  LKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQT 480

Query: 479  LLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA 538
            LLQKLQ  +G+HEHFNSW+ GF+IHHYAGKVSYD+ GFCERNRDVLF DLIELMQ+SE  
Sbjct: 481  LLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELP 540

Query: 539  FLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEE 598
            F++ LFPE L  DKKGRP+TAGSKIKKQANDLV+TLM+CTPHYIRCIKPNETK+PRDWEE
Sbjct: 541  FIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEE 600

Query: 599  NRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLR 658
            +RVKHQVEYLGLKENIRVRRAG+AYRR F KFLQRYAILT  TWP W+G+E+QGV HLL+
Sbjct: 601  SRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQ 660

Query: 659  AVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMRE 718
            +VNM+ DQ+Q+G +KVF+K PESLFLLEE+RERK+DG+AR IQK+WR+ VA +KY +MRE
Sbjct: 661  SVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMRE 720

Query: 719  EASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPI 778
            EAS++LLNKKERRRNSINRNF+GDY+G+EE PEL+QF+GKRE++DFAD+VTKYDRRFK +
Sbjct: 721  EASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGV 780

Query: 779  KRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDA 838
            KRDL+LTPKC+Y+IGREKVK+GP+KG V EVLK+K++I+ +  VSLST QDD FIL E  
Sbjct: 781  KRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQE 840

Query: 839  ADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWG---GGGTRSVTFS 895
             DS LESVFKTEF+SLL KR+EE T++ LPL FS+TL+ ++KKE WG    GG+R V F 
Sbjct: 841  YDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFH 900

Query: 896  RGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAK----GKPRRSSQAPTRAAPAPPR 951
            +GFGDLAVLK   + L VS+G GLPK+S+PTR+   +        +++  P RAAP PP 
Sbjct: 901  QGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPP- 959

Query: 952  GMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSE-------HN 1004
            G  +NGV    R   +P       G+ R  +    TS+     PR +  S         +
Sbjct: 960  GYHQNGV---IRNQYVPYP--HAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPES 1014

Query: 1005 TEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQ--PRTHGPRCRALYQYVGQDVDELSF 1062
             +FL VPDQG AG++R+ +   RP P  GRPKPQ  P+   P+C+ALY Y  QD DELSF
Sbjct: 1015 LDFLKVPDQGAAGVRRQTT--SRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSF 1072

Query: 1063 NVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI 1098
            N N++I+I+ EDPSGWW GRL G++GLFP NYV KI
Sbjct: 1073 NANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI 1108


>gi|124494247 myosin IC isoform b [Homo sapiens]
          Length = 1044

 Score =  612 bits (1579), Expect = e-175
 Identities = 334/726 (46%), Positives = 460/726 (63%), Gaps = 34/726 (4%)

Query: 18  GVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           GV D VLL   T E A   NLR+RF ++ I+TYIG VL+SVNP++ +  ++ + ++ Y+G
Sbjct: 28  GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRG 87

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
            + YE PPH++A+ D +YR +  +  +Q V+ISGESGAGKT A K ++ + ++     E+
Sbjct: 88  VSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPER 147

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
              V+D +LQSNP+LEAFGNAKT+RN+NSSRFGKY ++QF   G P GG I ++LLEKSR
Sbjct: 148 GGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSR 207

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
           VV QN  ERNFHI+YQLLEG  +E  + LGL   P  Y YL +    +V   +D+SD+  
Sbjct: 208 VVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKV 267

Query: 256 TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFC--EDGNYARVESVDLLAFPAYLLGID 313
              A+ VI       + +L +VA +LHLGNI F   E+ N A+V + + L +   LL ++
Sbjct: 268 VRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESN-AQVTTENQLKYLTRLLSVE 326

Query: 314 SGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373
              L+E LT RK+ +    + E +   LN+EQAAY RDALAK +Y+R F +LV  INR++
Sbjct: 327 GSTLREALTHRKIIA----KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSL 382

Query: 374 QKPQEEYS-------IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEY 426
                E         +G+LDIYGFE+FQ N FEQFCIN+ NEKLQQ+FIELTLK+EQEEY
Sbjct: 383 ASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEY 442

Query: 427 VQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAA 486
             EGI W P+QYFNNK++CDL+E K    GI+S+LD+ C      G   D T L+KL+  
Sbjct: 443 EAEGIAWEPVQYFNNKIICDLVEEKFK--GIISILDEECL---RPGEATDLTFLEKLEDT 497

Query: 487 VGTHEHF-----------NSWSAG-FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           V  H HF            S   G F + HYAG+V+Y V+GF ++N D+LF +L E M +
Sbjct: 498 VKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCS 557

Query: 535 SEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPR 594
           S+   +   F      DKK RP T  ++ K     LV  L    P Y+RCIKPN+ K+P 
Sbjct: 558 SKNPIMSQCFDRSELSDKK-RPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPG 616

Query: 595 DWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQ 654
            ++E  ++HQV+YLGL EN+RVRRAGFAYRR++  FLQRY  L PETWP W G  + GV 
Sbjct: 617 RFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVA 676

Query: 655 HLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYE 714
            L+R +  +P++Y+MG TK+F++ P++LF  E+  E +    A  IQ AWR     +K+ 
Sbjct: 677 VLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 736

Query: 715 EMREEA 720
            ++  A
Sbjct: 737 RVKRSA 742



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 46/148 (31%), Positives = 73/148 (49%), Gaps = 22/148 (14%)

Query: 696 FARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEE-RPELRQ 754
           + R+I   W++ +      + +  AS I   KK+    S+ R F+   LG +E  P + Q
Sbjct: 840 YCRSISPEWKQQL------QQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQ 893

Query: 755 FLGKRERVDFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKK 813
            LG  E + +A  V KYDR+ +KP  R L+LTP  V ++   KVK+             +
Sbjct: 894 ALGS-EPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQ-------------R 939

Query: 814 VDIQALRGVSLSTRQDDFFILQEDAADS 841
           +D   L G+S+S+  D  F+L    AD+
Sbjct: 940 IDYANLTGISVSSLSDSLFVLHVQRADN 967


>gi|124494238 myosin IC isoform a [Homo sapiens]
          Length = 1063

 Score =  612 bits (1579), Expect = e-175
 Identities = 334/726 (46%), Positives = 460/726 (63%), Gaps = 34/726 (4%)

Query: 18  GVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           GV D VLL   T E A   NLR+RF ++ I+TYIG VL+SVNP++ +  ++ + ++ Y+G
Sbjct: 47  GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRG 106

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
            + YE PPH++A+ D +YR +  +  +Q V+ISGESGAGKT A K ++ + ++     E+
Sbjct: 107 VSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPER 166

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
              V+D +LQSNP+LEAFGNAKT+RN+NSSRFGKY ++QF   G P GG I ++LLEKSR
Sbjct: 167 GGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSR 226

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
           VV QN  ERNFHI+YQLLEG  +E  + LGL   P  Y YL +    +V   +D+SD+  
Sbjct: 227 VVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKV 286

Query: 256 TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFC--EDGNYARVESVDLLAFPAYLLGID 313
              A+ VI       + +L +VA +LHLGNI F   E+ N A+V + + L +   LL ++
Sbjct: 287 VRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESN-AQVTTENQLKYLTRLLSVE 345

Query: 314 SGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373
              L+E LT RK+ +    + E +   LN+EQAAY RDALAK +Y+R F +LV  INR++
Sbjct: 346 GSTLREALTHRKIIA----KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSL 401

Query: 374 QKPQEEYS-------IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEY 426
                E         +G+LDIYGFE+FQ N FEQFCIN+ NEKLQQ+FIELTLK+EQEEY
Sbjct: 402 ASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEY 461

Query: 427 VQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAA 486
             EGI W P+QYFNNK++CDL+E K    GI+S+LD+ C      G   D T L+KL+  
Sbjct: 462 EAEGIAWEPVQYFNNKIICDLVEEKFK--GIISILDEECL---RPGEATDLTFLEKLEDT 516

Query: 487 VGTHEHF-----------NSWSAG-FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           V  H HF            S   G F + HYAG+V+Y V+GF ++N D+LF +L E M +
Sbjct: 517 VKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCS 576

Query: 535 SEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPR 594
           S+   +   F      DKK RP T  ++ K     LV  L    P Y+RCIKPN+ K+P 
Sbjct: 577 SKNPIMSQCFDRSELSDKK-RPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPG 635

Query: 595 DWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQ 654
            ++E  ++HQV+YLGL EN+RVRRAGFAYRR++  FLQRY  L PETWP W G  + GV 
Sbjct: 636 RFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVA 695

Query: 655 HLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYE 714
            L+R +  +P++Y+MG TK+F++ P++LF  E+  E +    A  IQ AWR     +K+ 
Sbjct: 696 VLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 755

Query: 715 EMREEA 720
            ++  A
Sbjct: 756 RVKRSA 761



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 46/148 (31%), Positives = 73/148 (49%), Gaps = 22/148 (14%)

Query: 696 FARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEE-RPELRQ 754
           + R+I   W++ +      + +  AS I   KK+    S+ R F+   LG +E  P + Q
Sbjct: 859 YCRSISPEWKQQL------QQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQ 912

Query: 755 FLGKRERVDFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKK 813
            LG  E + +A  V KYDR+ +KP  R L+LTP  V ++   KVK+             +
Sbjct: 913 ALGS-EPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQ-------------R 958

Query: 814 VDIQALRGVSLSTRQDDFFILQEDAADS 841
           +D   L G+S+S+  D  F+L    AD+
Sbjct: 959 IDYANLTGISVSSLSDSLFVLHVQRADN 986


>gi|124494240 myosin IC isoform c [Homo sapiens]
          Length = 1028

 Score =  612 bits (1579), Expect = e-175
 Identities = 334/726 (46%), Positives = 460/726 (63%), Gaps = 34/726 (4%)

Query: 18  GVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           GV D VLL   T E A   NLR+RF ++ I+TYIG VL+SVNP++ +  ++ + ++ Y+G
Sbjct: 12  GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRG 71

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
            + YE PPH++A+ D +YR +  +  +Q V+ISGESGAGKT A K ++ + ++     E+
Sbjct: 72  VSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPER 131

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
              V+D +LQSNP+LEAFGNAKT+RN+NSSRFGKY ++QF   G P GG I ++LLEKSR
Sbjct: 132 GGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSR 191

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
           VV QN  ERNFHI+YQLLEG  +E  + LGL   P  Y YL +    +V   +D+SD+  
Sbjct: 192 VVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKV 251

Query: 256 TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFC--EDGNYARVESVDLLAFPAYLLGID 313
              A+ VI       + +L +VA +LHLGNI F   E+ N A+V + + L +   LL ++
Sbjct: 252 VRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESN-AQVTTENQLKYLTRLLSVE 310

Query: 314 SGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373
              L+E LT RK+ +    + E +   LN+EQAAY RDALAK +Y+R F +LV  INR++
Sbjct: 311 GSTLREALTHRKIIA----KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSL 366

Query: 374 QKPQEEYS-------IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEY 426
                E         +G+LDIYGFE+FQ N FEQFCIN+ NEKLQQ+FIELTLK+EQEEY
Sbjct: 367 ASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEY 426

Query: 427 VQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAA 486
             EGI W P+QYFNNK++CDL+E K    GI+S+LD+ C      G   D T L+KL+  
Sbjct: 427 EAEGIAWEPVQYFNNKIICDLVEEKFK--GIISILDEECL---RPGEATDLTFLEKLEDT 481

Query: 487 VGTHEHF-----------NSWSAG-FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           V  H HF            S   G F + HYAG+V+Y V+GF ++N D+LF +L E M +
Sbjct: 482 VKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCS 541

Query: 535 SEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPR 594
           S+   +   F      DKK RP T  ++ K     LV  L    P Y+RCIKPN+ K+P 
Sbjct: 542 SKNPIMSQCFDRSELSDKK-RPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPG 600

Query: 595 DWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQ 654
            ++E  ++HQV+YLGL EN+RVRRAGFAYRR++  FLQRY  L PETWP W G  + GV 
Sbjct: 601 RFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVA 660

Query: 655 HLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYE 714
            L+R +  +P++Y+MG TK+F++ P++LF  E+  E +    A  IQ AWR     +K+ 
Sbjct: 661 VLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFL 720

Query: 715 EMREEA 720
            ++  A
Sbjct: 721 RVKRSA 726



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 46/148 (31%), Positives = 73/148 (49%), Gaps = 22/148 (14%)

Query: 696 FARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEE-RPELRQ 754
           + R+I   W++ +      + +  AS I   KK+    S+ R F+   LG +E  P + Q
Sbjct: 824 YCRSISPEWKQQL------QQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQ 877

Query: 755 FLGKRERVDFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKK 813
            LG  E + +A  V KYDR+ +KP  R L+LTP  V ++   KVK+             +
Sbjct: 878 ALGS-EPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQ-------------R 923

Query: 814 VDIQALRGVSLSTRQDDFFILQEDAADS 841
           +D   L G+S+S+  D  F+L    AD+
Sbjct: 924 IDYANLTGISVSSLSDSLFVLHVQRADN 951


>gi|194328685 myosin IB isoform 1 [Homo sapiens]
          Length = 1136

 Score =  611 bits (1575), Expect = e-174
 Identities = 325/710 (45%), Positives = 451/710 (63%), Gaps = 31/710 (4%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           GV DMVLL  + E+    NL+KRF    I+TYIGSV+ISVNP++ +P ++  +++ Y+  
Sbjct: 16  GVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNR 75

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKV 137
             YE  PHI+AL+D  YR++    ++QC++I+GESGAGKT A+K +M Y++ V G G +V
Sbjct: 76  NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEV 135

Query: 138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRV 197
             VK+ +LQSNP+LEAFGNAKTVRN+NSSRFGKY +I+F   G+P GG ISN+LLEKSRV
Sbjct: 136 NQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRV 195

Query: 198 VMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETL 257
           V Q   ERNFH++YQLL GAS+E    L L      Y     D+ +V+G DD ++F    
Sbjct: 196 VKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVR 255

Query: 258 SAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDG-----NYARVESVDLLAFPAYLLGI 312
           +AMQ++G      + VL +VA +L LGNI F  +      + ++++  + L     L GI
Sbjct: 256 NAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGI 315

Query: 313 DSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRA 372
           D   L+   + R +++    + E ++ TLNV QA Y RDALAK LY+RLF +LV  IN +
Sbjct: 316 DQSVLERAFSFRTVEA----KQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINES 371

Query: 373 M--QKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEG 430
           +  Q    +  +GVLDIYGFEIF+ N FEQF IN+ NEKLQQIFIELTLK EQEEY++E 
Sbjct: 372 IKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIRED 431

Query: 431 IRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTH 490
           I WT I YFNN ++CDLIEN  +  GI+++LD+ C      G   D+T L+KL     TH
Sbjct: 432 IEWTHIDYFNNAIICDLIENNTN--GILAMLDEECL---RPGTVTDETFLEKLNQVCATH 486

Query: 491 EHFNSWSAG--------------FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSE 536
           +HF S  +               F I HYAGKV Y V GF ++N D+L+ DL + M  + 
Sbjct: 487 QHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAS 546

Query: 537 QAFLRMLFPEKLDGD-KKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRD 595
            A ++ LFPE         RP TAGS+ K     L+  L    P+YIRCIKPN+ K    
Sbjct: 547 HALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHI 606

Query: 596 WEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQH 655
           + E  V HQ+ YLGL EN+RVRRAG+A+R+ +   L+RY +L  +TWP W+G  R GV+ 
Sbjct: 607 FNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEV 666

Query: 656 LLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWR 705
           L   + +  ++Y  G +K+F++NP +LF LE++R+++ +  A  IQK +R
Sbjct: 667 LFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYR 716



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 23/180 (12%)

Query: 713  YEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGK-RERVDFADSVTKY 771
            YEE + EAS +  +KK    +S+ + F G YL + + P+ ++      E++  A+ V K 
Sbjct: 938  YEE-KLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKI 996

Query: 772  DR-RFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDD 830
            +R   K   R  +LT   + +  +       + GQ+    K +V +  +  VS+S++ D 
Sbjct: 997  NRANGKSTSRIFLLTNNNLLLADQ-------KSGQI----KSEVPLVDVTKVSMSSQNDG 1045

Query: 831  FFILQ----EDAA---DSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSD--TLQFRVKK 881
            FF +      +AA   D    S    E  + L +     T++ L +  SD   +QFR  K
Sbjct: 1046 FFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDK 1105


>gi|44889481 myosin IB isoform 2 [Homo sapiens]
          Length = 1078

 Score =  611 bits (1575), Expect = e-174
 Identities = 325/710 (45%), Positives = 451/710 (63%), Gaps = 31/710 (4%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           GV DMVLL  + E+    NL+KRF    I+TYIGSV+ISVNP++ +P ++  +++ Y+  
Sbjct: 16  GVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNR 75

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKV 137
             YE  PHI+AL+D  YR++    ++QC++I+GESGAGKT A+K +M Y++ V G G +V
Sbjct: 76  NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEV 135

Query: 138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRV 197
             VK+ +LQSNP+LEAFGNAKTVRN+NSSRFGKY +I+F   G+P GG ISN+LLEKSRV
Sbjct: 136 NQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRV 195

Query: 198 VMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETL 257
           V Q   ERNFH++YQLL GAS+E    L L      Y     D+ +V+G DD ++F    
Sbjct: 196 VKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVR 255

Query: 258 SAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDG-----NYARVESVDLLAFPAYLLGI 312
           +AMQ++G      + VL +VA +L LGNI F  +      + ++++  + L     L GI
Sbjct: 256 NAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGI 315

Query: 313 DSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRA 372
           D   L+   + R +++    + E ++ TLNV QA Y RDALAK LY+RLF +LV  IN +
Sbjct: 316 DQSVLERAFSFRTVEA----KQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINES 371

Query: 373 M--QKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEG 430
           +  Q    +  +GVLDIYGFEIF+ N FEQF IN+ NEKLQQIFIELTLK EQEEY++E 
Sbjct: 372 IKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIRED 431

Query: 431 IRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTH 490
           I WT I YFNN ++CDLIEN  +  GI+++LD+ C      G   D+T L+KL     TH
Sbjct: 432 IEWTHIDYFNNAIICDLIENNTN--GILAMLDEECL---RPGTVTDETFLEKLNQVCATH 486

Query: 491 EHFNSWSAG--------------FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSE 536
           +HF S  +               F I HYAGKV Y V GF ++N D+L+ DL + M  + 
Sbjct: 487 QHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAS 546

Query: 537 QAFLRMLFPEKLDGD-KKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRD 595
            A ++ LFPE         RP TAGS+ K     L+  L    P+YIRCIKPN+ K    
Sbjct: 547 HALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHI 606

Query: 596 WEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQH 655
           + E  V HQ+ YLGL EN+RVRRAG+A+R+ +   L+RY +L  +TWP W+G  R GV+ 
Sbjct: 607 FNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEV 666

Query: 656 LLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWR 705
           L   + +  ++Y  G +K+F++NP +LF LE++R+++ +  A  IQK +R
Sbjct: 667 LFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYR 716



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 23/180 (12%)

Query: 713  YEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGK-RERVDFADSVTKY 771
            YEE + EAS +  +KK    +S+ + F G YL + + P+ ++      E++  A+ V K 
Sbjct: 880  YEE-KLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKI 938

Query: 772  DR-RFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDD 830
            +R   K   R  +LT   + +  +       + GQ+    K +V +  +  VS+S++ D 
Sbjct: 939  NRANGKSTSRIFLLTNNNLLLADQ-------KSGQI----KSEVPLVDVTKVSMSSQNDG 987

Query: 831  FFILQ----EDAA---DSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSD--TLQFRVKK 881
            FF +      +AA   D    S    E  + L +     T++ L +  SD   +QFR  K
Sbjct: 988  FFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDK 1047


>gi|240120050 myosin IB isoform 1 [Homo sapiens]
          Length = 1136

 Score =  611 bits (1575), Expect = e-174
 Identities = 325/710 (45%), Positives = 451/710 (63%), Gaps = 31/710 (4%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           GV DMVLL  + E+    NL+KRF    I+TYIGSV+ISVNP++ +P ++  +++ Y+  
Sbjct: 16  GVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNR 75

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKV 137
             YE  PHI+AL+D  YR++    ++QC++I+GESGAGKT A+K +M Y++ V G G +V
Sbjct: 76  NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEV 135

Query: 138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRV 197
             VK+ +LQSNP+LEAFGNAKTVRN+NSSRFGKY +I+F   G+P GG ISN+LLEKSRV
Sbjct: 136 NQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRV 195

Query: 198 VMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETL 257
           V Q   ERNFH++YQLL GAS+E    L L      Y     D+ +V+G DD ++F    
Sbjct: 196 VKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVR 255

Query: 258 SAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDG-----NYARVESVDLLAFPAYLLGI 312
           +AMQ++G      + VL +VA +L LGNI F  +      + ++++  + L     L GI
Sbjct: 256 NAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGI 315

Query: 313 DSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRA 372
           D   L+   + R +++    + E ++ TLNV QA Y RDALAK LY+RLF +LV  IN +
Sbjct: 316 DQSVLERAFSFRTVEA----KQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINES 371

Query: 373 M--QKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEG 430
           +  Q    +  +GVLDIYGFEIF+ N FEQF IN+ NEKLQQIFIELTLK EQEEY++E 
Sbjct: 372 IKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIRED 431

Query: 431 IRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTH 490
           I WT I YFNN ++CDLIEN  +  GI+++LD+ C      G   D+T L+KL     TH
Sbjct: 432 IEWTHIDYFNNAIICDLIENNTN--GILAMLDEECL---RPGTVTDETFLEKLNQVCATH 486

Query: 491 EHFNSWSAG--------------FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSE 536
           +HF S  +               F I HYAGKV Y V GF ++N D+L+ DL + M  + 
Sbjct: 487 QHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAS 546

Query: 537 QAFLRMLFPEKLDGD-KKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRD 595
            A ++ LFPE         RP TAGS+ K     L+  L    P+YIRCIKPN+ K    
Sbjct: 547 HALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHI 606

Query: 596 WEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQH 655
           + E  V HQ+ YLGL EN+RVRRAG+A+R+ +   L+RY +L  +TWP W+G  R GV+ 
Sbjct: 607 FNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEV 666

Query: 656 LLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWR 705
           L   + +  ++Y  G +K+F++NP +LF LE++R+++ +  A  IQK +R
Sbjct: 667 LFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYR 716



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 23/180 (12%)

Query: 713  YEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGK-RERVDFADSVTKY 771
            YEE + EAS +  +KK    +S+ + F G YL + + P+ ++      E++  A+ V K 
Sbjct: 938  YEE-KLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKI 996

Query: 772  DR-RFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDD 830
            +R   K   R  +LT   + +  +       + GQ+    K +V +  +  VS+S++ D 
Sbjct: 997  NRANGKSTSRIFLLTNNNLLLADQ-------KSGQI----KSEVPLVDVTKVSMSSQNDG 1045

Query: 831  FFILQ----EDAA---DSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSD--TLQFRVKK 881
            FF +      +AA   D    S    E  + L +     T++ L +  SD   +QFR  K
Sbjct: 1046 FFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDK 1105


>gi|254028267 myosin 1H [Homo sapiens]
          Length = 1022

 Score =  596 bits (1537), Expect = e-170
 Identities = 317/721 (43%), Positives = 452/721 (62%), Gaps = 29/721 (4%)

Query: 18  GVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           GV D VLL   T E A   NLRKRF ++ I+TYIG++L+SVNP++++  +T  +++LYQG
Sbjct: 12  GVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQG 71

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
              +E PPH+YA+ DN YR M  +  N  ++ISGESGAGKT A+K I+ Y +      + 
Sbjct: 72  VNFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQS 131

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
           +Q  +D +L SNP+LEAFGNA+T+RN+NSSRFGKY +IQF   G P GG I ++L+EKSR
Sbjct: 132 LQIARDRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSR 191

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
           VV QNE ERNFHI+YQLL G  +E+   LGL   P  Y YL+Q    +     D++D+  
Sbjct: 192 VVYQNEGERNFHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKT 251

Query: 256 TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDG-NYARVESVDLLAFPAYLLGIDS 314
             +A  VI    +  + +  ++A +LHLGNI F ED    A +     + + A LLG+  
Sbjct: 252 VSNAFSVIDFTEADLENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHP 311

Query: 315 GRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374
             L E LT RK+++    ++E +   L +E + Y RDA+AK +Y R F +LV  IN ++ 
Sbjct: 312 SVLLEALTHRKIEA----KTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLV 367

Query: 375 KPQ--EEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIR 432
                 +  IG+LDIYGFE+F KNGFEQFCIN+ NEKLQQ+ IE TLKAEQ EY  EGI 
Sbjct: 368 NKDFTRKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIE 427

Query: 433 WTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEH 492
           W PI+YFNNK++CDL+E +    GI+S+LD+ C      G   D + L+KL+  VG H H
Sbjct: 428 WEPIKYFNNKIICDLVEER--HKGIISILDEECI---RPGPATDLSFLEKLEEKVGKHAH 482

Query: 493 FNS-------------WSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAF 539
           F +             W   F + HYAG+V+Y   GF E+N D+L+  L E++  S+   
Sbjct: 483 FETRKLAGPKGRKRIGWME-FRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCKSKNII 541

Query: 540 LRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEEN 599
           LR  F    + + + RP T G++ K   + L+ TL+   P YIRCIKPN+ K P  +++ 
Sbjct: 542 LRECF-LLAELENRRRPPTVGTQFKNSLSSLLETLISKEPSYIRCIKPNDRKEPSKFDDF 600

Query: 600 RVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRA 659
            ++HQ++YLGL E++RVRRAGFAYRR++  FLQRY  L P+TWP W G   +GV+ L++ 
Sbjct: 601 LIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPAEGVERLIKY 660

Query: 660 VNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREE 719
           +  +P++Y++G TK+F++ P +LF  E+  E         IQ  ++R +  R+Y + R+ 
Sbjct: 661 IGYKPEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKKRQA 720

Query: 720 A 720
           A
Sbjct: 721 A 721



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 17/145 (11%)

Query: 700 IQKAWRRHVAVRK-YEEMREEASNILLNKKERRRNSINRNFVGDYLGLEE-RPELRQFLG 757
           +QK  R   A RK   + +   S I   +K+    S+N+ FV   +   +  P++ Q + 
Sbjct: 816 VQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQPFVNSRIDEGDINPKVLQLIS 875

Query: 758 KRERVDFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDI 816
             E++ +   V KYDR+ FK  +R LILT K  YV+   K+K+             K++ 
Sbjct: 876 -HEKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAKIKQ-------------KIEY 921

Query: 817 QALRGVSLSTRQDDFFILQEDAADS 841
            AL+GVS S   D   ++     DS
Sbjct: 922 SALKGVSTSNLSDGILVIHVSPEDS 946


>gi|4885503 myosin IA [Homo sapiens]
          Length = 1043

 Score =  571 bits (1472), Expect = e-162
 Identities = 318/735 (43%), Positives = 462/735 (62%), Gaps = 41/735 (5%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           GV+D+VLL  + E+++  NL+ R+ +  I+TYIG+V+ISVNP++Q+P +    I  YQ  
Sbjct: 9   GVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDY 68

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKV 137
             YE  PHIYAL +  Y+++     +QC++I+GESG+GKT A+K +M Y++ V G GE+V
Sbjct: 69  TFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQV 128

Query: 138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRV 197
             VK+ +LQSNP+LEAFGNAKT+RNNNSSRFGKY +I+F   G P GG I+N+LLEKSR+
Sbjct: 129 NSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRL 188

Query: 198 VMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDRSDFGET 256
           V Q + ERNFHI+YQLL GA ++  + L L      Y YLN  +  +VDG DD S F   
Sbjct: 189 VKQLKGERNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNH-EVSRVDGMDDASSFRAV 247

Query: 257 LSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDL-----LAFPAYLLG 311
            SAM VIG      + VL++ + +L LGN+   ++   + + +  +     +     ++G
Sbjct: 248 QSAMAVIGFSEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVG 307

Query: 312 IDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINR 371
           ++S  ++  L SR M++      E +   LNV QA Y RDALAK +Y+RLFD++V  IN 
Sbjct: 308 LNSEEVERALCSRTMET----AKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINE 363

Query: 372 AMQK--PQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQE 429
           +++    +++  +GVLDIYGFEI + N FEQF IN+ NEKLQQ+FIE+TLK EQEEY +E
Sbjct: 364 SIKVGIGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKRE 423

Query: 430 GIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGT 489
           GI WT + YF+N ++C LIE+  +  GI+++LD+ C      G  +D T L KL      
Sbjct: 424 GIPWTKVDYFDNGIICKLIEH--NQRGILAMLDEECL---RPGVVSDSTFLAKLNQLFSK 478

Query: 490 HEHFNS--------------WSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTS 535
           H H+ S                + F I HYAGKV+Y+V+ F ++N D+LF DL++ M  +
Sbjct: 479 HGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLLQAMWKA 538

Query: 536 EQAFLRMLFPEKLDGDKK----GRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETK 591
           +   LR LFPE   G+ K     RP TAG++ K     L+  L   +P+YIRCIKPNE +
Sbjct: 539 QHPLLRSLFPE---GNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQ 595

Query: 592 RPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQ 651
           +   +  + V  Q  YLGL EN+RVRRAG+A+R+ +  FL+RY +L+  TWP W G +R+
Sbjct: 596 QRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWNGGDRE 655

Query: 652 GVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVR 711
           GV+ +L  ++M   +   G TK+F+++P++LF LEE R  +    A  IQK +R      
Sbjct: 656 GVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWRCRT 715

Query: 712 KYEEMREEASNILLN 726
            Y+ MR+  S IL++
Sbjct: 716 HYQLMRK--SQILIS 728



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 50/191 (26%), Positives = 88/191 (46%), Gaps = 22/191 (11%)

Query: 702  KAWRRHVAVRKYEEMREE--ASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR 759
            K +R  ++ ++ E +RE+  AS +   KK     S+   F GDY+GL+  P+L++  G  
Sbjct: 830  KRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGE 889

Query: 760  E-RVDFADSVTKYDR-RFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQ 817
            E  V  A++V K +R   K   R L+LT   V +   +K +            K  + + 
Sbjct: 890  EGPVLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQ-----------AKIVIGLD 938

Query: 818  ALRGVSLSTRQDDFFILQ-------EDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLT 870
             + GVS+++ +D  F L            D  L S    E ++ + +   +AT+R L +T
Sbjct: 939  NVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT 998

Query: 871  FSDTLQFRVKK 881
             ++    R K+
Sbjct: 999  VTEKFSVRFKE 1009


>gi|51100974 myosin ID [Homo sapiens]
          Length = 1006

 Score =  539 bits (1388), Expect = e-153
 Identities = 302/742 (40%), Positives = 446/742 (60%), Gaps = 33/742 (4%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           G  D VL+  ++     ANLR RF    I+T+IG V++SVNP+K +  +    I+ Y+G 
Sbjct: 10  GKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGR 69

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK- 136
             YE PPH++A+ D  Y+ M    ++ C++ISGESGAGKT A+KYIM YI+ ++   ++ 
Sbjct: 70  ELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRA 129

Query: 137 -VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKS 195
            V+ VK+++L+SN +LEAFGNAKT RN+NSSRFGKY +I F   G+P GG I+N+LLEKS
Sbjct: 130 EVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKS 189

Query: 196 RVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
           RV++Q   ER+FH +YQLL+G S++  ++L L      Y             +D ++F  
Sbjct: 190 RVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRV 249

Query: 256 TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSG 315
              AM+VIG  P   Q V +++A ILHLGN+ F  DG+   +E+  +++  A LL   + 
Sbjct: 250 VADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTD 309

Query: 316 RLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQK 375
            +++ L  R + +   GR + I+     ++A+Y RDA AK +Y RLF ++V  IN  ++ 
Sbjct: 310 MVEKALLYRTVAT---GR-DIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEV 365

Query: 376 PQEEYS-------IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQ 428
              + +       IGVLDIYGFEIF  N FEQFCIN+ NEKLQQ+FI+L LK EQEEY +
Sbjct: 366 KNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQR 425

Query: 429 EGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVG 488
           EGI W  I YFNN+++ DL+E +    GI+++LDD C  +   G   D+  L+ L + +G
Sbjct: 426 EGIPWKHIDYFNNQIIVDLVEQQ--HKGIIAILDDACMNV---GKVTDEMFLEALNSKLG 480

Query: 489 THEHFNS-----------WSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQ 537
            H HF+S           +   F I HYAG V Y V GF ++N+D LF D   LM  S  
Sbjct: 481 KHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSN 540

Query: 538 AFLRMLFPE-KLD-GDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRD 595
             L+ ++PE KL   +   RP TA +  K     LV  L    P+Y+RCIKPN+ K P+ 
Sbjct: 541 PVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQI 600

Query: 596 WEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRW-RGDERQGVQ 654
           +++ R +HQVEYLGL EN+RVRRAGFA+R+ + KFL RY +++  TWP      +++ V+
Sbjct: 601 FDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVK 660

Query: 655 HLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYE 714
            L+     + D    G TK+F++ P +LF LEE+R +        +QK WR  +A  +Y+
Sbjct: 661 KLIERCGFQ-DDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYK 719

Query: 715 EMREEASNILLNKKERRRNSIN 736
             +   + I   ++ + ++ I+
Sbjct: 720 RTKAALTIIRYYRRYKVKSYIH 741


>gi|239582755 myosin IG [Homo sapiens]
          Length = 1018

 Score =  507 bits (1306), Expect = e-143
 Identities = 306/735 (41%), Positives = 422/735 (57%), Gaps = 45/735 (6%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGA 77
           G  D VLL Q+T +    NL+ RF    I+TYIG VL+SVNP++++P +    I  YQG 
Sbjct: 10  GKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGR 69

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK- 136
             YE PPH+YA+ +  Y+ M     + C++ISGESGAGKT A+K+IM YI+ V+   ++ 
Sbjct: 70  ELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRA 129

Query: 137 -VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKS 195
            V+ VKD++L+S  +LEAFGNA+T RN+NSSRFGKY +I F   G+P GG I ++LLEKS
Sbjct: 130 EVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKS 189

Query: 196 RVVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQS-----DTYQVDGTDD 249
           RV+ Q+  ERNFH +YQLL G+  +Q   L L   P  Y + +Q        +    +D+
Sbjct: 190 RVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDE 249

Query: 250 RSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISF--CEDGNYAR----VESVDLL 303
           +S    T  AM+VIG  P   + V +++A ILHLGNI F   E+G   +    V    L+
Sbjct: 250 QSHQAVT-EAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALV 308

Query: 304 AFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFD 363
              A L       +   L +R + S  GGR E I       +A+Y RDA AK +Y RLF+
Sbjct: 309 DHVAELTATPRDLVLRSLLARTVAS--GGR-ELIEKGHTAAEASYARDACAKAVYQRLFE 365

Query: 364 FLVEAINRAMQ-------KPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIE 416
           ++V  IN  M+       +  ++  IGVLDIYGFE+F  N FEQFCIN+ NEKLQQ+FI+
Sbjct: 366 WVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQ 425

Query: 417 LTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGAD 476
           L LK EQEEY +EGI W  ++YFNN  + DL+E      GI++VLD+ C+   + G   D
Sbjct: 426 LILKQEQEEYEREGITWQSVEYFNNATIVDLVER--PHRGILAVLDEACS---SAGTITD 480

Query: 477 QTLLQKLQAAVGTHEHFNS-----------WSAGFVIHHYAGKVSYDVSGFCERNRDVLF 525
           +  LQ L      H H+ S           +   F I HYAG V+Y V GF ++NRD LF
Sbjct: 481 RIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLF 540

Query: 526 SDLIELMQTSEQAFLRMLFPEKLDG--DKKGRPSTAGSKIKKQANDLVATLMRCTPHYIR 583
            D   L+  S    LR ++P+      +   RP TAG+  K     LV  L    P Y+R
Sbjct: 541 QDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVR 600

Query: 584 CIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWP 643
           CIKPNE K     +EN  +HQV YLGL EN+RVRRAGFA R+ +++FL RY +    TWP
Sbjct: 601 CIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWP 660

Query: 644 -RWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQK 702
               G ++  V  LL    ++ D    G +K+F+++P +L  LE+ R R        +QK
Sbjct: 661 NHLLGSDKAAVSALLEQHGLQGD-VAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQK 719

Query: 703 AWRRHVAVRKYEEMR 717
           AWR  +A  +   +R
Sbjct: 720 AWRGTLARWRCRRLR 734


>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
          Length = 2175

 Score =  481 bits (1237), Expect = e-135
 Identities = 283/749 (37%), Positives = 422/749 (56%), Gaps = 60/749 (8%)

Query: 12  HNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREI 71
           H     GV+DM+ L  + E  I  NL  R+ D  I+TY GS+L++VNP++ +  ++   I
Sbjct: 60  HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 119

Query: 72  DLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVS 131
             Y      E PPHI+A+ DN Y NM  +  +QC IISGESGAGKT + K I+ +++ +S
Sbjct: 120 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAIS 179

Query: 132 GGGEKVQH--VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISN 189
           G     QH  ++  +L++ P+LEAFGNAKT+RN+NSSRFGKY +I F++ G  +G KI  
Sbjct: 180 G-----QHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQ 234

Query: 190 FLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDD 249
           +LLEKSRV  Q  +ERN+H++Y +LEG S++Q++ LGL     Y YL   +    +G  D
Sbjct: 235 YLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVD 294

Query: 250 RSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP--- 306
             ++    SAM+V+    +    + +L+A ILHLGN+ + E   +  +++ ++L  P   
Sbjct: 295 SQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQY-EARTFENLDACEVLFSPSLA 353

Query: 307 --AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDF 364
             A LL ++   L   LTSR + +    R E+++  L+ EQA   RDA  KG+Y RLF +
Sbjct: 354 TAASLLEVNPPDLMSCLTSRTLIT----RGETVSTPLSREQALDVRDAFVKGIYGRLFVW 409

Query: 365 LVEAINRAMQKPQEE------YSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 418
           +V+ IN A+ KP  +       SIG+LDI+GFE F  N FEQ CINF NE LQQ F+   
Sbjct: 410 IVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHV 469

Query: 419 LKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT 478
            K EQEEY  E I W  I++ +N+   D+I NK  P  I+S++D+          G D T
Sbjct: 470 FKLEQEEYDLESIDWLHIEFTDNQDALDMIANK--PMNIISLIDEESKFPK----GTDTT 523

Query: 479 LLQKLQAAVGTHEHF----NSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           +L KL +    + ++    N+    F I+H+AG V Y+  GF E+NRD L  D+I+L+ +
Sbjct: 524 MLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHS 583

Query: 535 SEQAFLRMLFPE--KLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKR 592
           S   F++ +F     +  + + R  T  S+ K+    L+ TL  C P ++RCIKPNE K+
Sbjct: 584 SRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKK 643

Query: 593 PRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWR-GDERQ 651
           P  ++ +    Q+ Y G+ E IR+RRAG+  R  F +F++RY +L P   P ++ GD R 
Sbjct: 644 PMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRG 703

Query: 652 GVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRER-------------------- 691
             Q +  AV    D +Q+G TK+F+K+   + LLE  R++                    
Sbjct: 704 TCQRMAEAVLGTHDDWQIGKTKIFLKDHHDM-LLEVERDKAITDRVILLQKVIRGFKDRS 762

Query: 692 ---KFDGFARTIQKAWRRHVAVRKYEEMR 717
              K    A  IQ+ WR H   + Y  MR
Sbjct: 763 NFLKLKNAATLIQRHWRGHNCRKNYGLMR 791


>gi|189083800 myosin VIIA isoform 3 [Homo sapiens]
          Length = 1204

 Score =  481 bits (1237), Expect = e-135
 Identities = 283/749 (37%), Positives = 422/749 (56%), Gaps = 60/749 (8%)

Query: 12  HNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREI 71
           H     GV+DM+ L  + E  I  NL  R+ D  I+TY GS+L++VNP++ +  ++   I
Sbjct: 60  HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 119

Query: 72  DLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVS 131
             Y      E PPHI+A+ DN Y NM  +  +QC IISGESGAGKT + K I+ +++ +S
Sbjct: 120 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAIS 179

Query: 132 GGGEKVQH--VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISN 189
           G     QH  ++  +L++ P+LEAFGNAKT+RN+NSSRFGKY +I F++ G  +G KI  
Sbjct: 180 G-----QHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQ 234

Query: 190 FLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDD 249
           +LLEKSRV  Q  +ERN+H++Y +LEG S++Q++ LGL     Y YL   +    +G  D
Sbjct: 235 YLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVD 294

Query: 250 RSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP--- 306
             ++    SAM+V+    +    + +L+A ILHLGN+ + E   +  +++ ++L  P   
Sbjct: 295 SQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQY-EARTFENLDACEVLFSPSLA 353

Query: 307 --AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDF 364
             A LL ++   L   LTSR + +    R E+++  L+ EQA   RDA  KG+Y RLF +
Sbjct: 354 TAASLLEVNPPDLMSCLTSRTLIT----RGETVSTPLSREQALDVRDAFVKGIYGRLFVW 409

Query: 365 LVEAINRAMQKPQEE------YSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 418
           +V+ IN A+ KP  +       SIG+LDI+GFE F  N FEQ CINF NE LQQ F+   
Sbjct: 410 IVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHV 469

Query: 419 LKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT 478
            K EQEEY  E I W  I++ +N+   D+I NK  P  I+S++D+          G D T
Sbjct: 470 FKLEQEEYDLESIDWLHIEFTDNQDALDMIANK--PMNIISLIDEESKFPK----GTDTT 523

Query: 479 LLQKLQAAVGTHEHF----NSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           +L KL +    + ++    N+    F I+H+AG V Y+  GF E+NRD L  D+I+L+ +
Sbjct: 524 MLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHS 583

Query: 535 SEQAFLRMLFPE--KLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKR 592
           S   F++ +F     +  + + R  T  S+ K+    L+ TL  C P ++RCIKPNE K+
Sbjct: 584 SRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKK 643

Query: 593 PRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWR-GDERQ 651
           P  ++ +    Q+ Y G+ E IR+RRAG+  R  F +F++RY +L P   P ++ GD R 
Sbjct: 644 PMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRG 703

Query: 652 GVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRER-------------------- 691
             Q +  AV    D +Q+G TK+F+K+   + LLE  R++                    
Sbjct: 704 TCQRMAEAVLGTHDDWQIGKTKIFLKDHHDM-LLEVERDKAITDRVILLQKVIRGFKDRS 762

Query: 692 ---KFDGFARTIQKAWRRHVAVRKYEEMR 717
              K    A  IQ+ WR H   + Y  MR
Sbjct: 763 NFLKLKNAATLIQRHWRGHNCRKNYGLMR 791


>gi|189083798 myosin VIIA isoform 1 [Homo sapiens]
          Length = 2215

 Score =  481 bits (1237), Expect = e-135
 Identities = 283/749 (37%), Positives = 422/749 (56%), Gaps = 60/749 (8%)

Query: 12  HNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREI 71
           H     GV+DM+ L  + E  I  NL  R+ D  I+TY GS+L++VNP++ +  ++   I
Sbjct: 60  HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 119

Query: 72  DLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVS 131
             Y      E PPHI+A+ DN Y NM  +  +QC IISGESGAGKT + K I+ +++ +S
Sbjct: 120 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAIS 179

Query: 132 GGGEKVQH--VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISN 189
           G     QH  ++  +L++ P+LEAFGNAKT+RN+NSSRFGKY +I F++ G  +G KI  
Sbjct: 180 G-----QHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQ 234

Query: 190 FLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDD 249
           +LLEKSRV  Q  +ERN+H++Y +LEG S++Q++ LGL     Y YL   +    +G  D
Sbjct: 235 YLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVD 294

Query: 250 RSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP--- 306
             ++    SAM+V+    +    + +L+A ILHLGN+ + E   +  +++ ++L  P   
Sbjct: 295 SQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQY-EARTFENLDACEVLFSPSLA 353

Query: 307 --AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDF 364
             A LL ++   L   LTSR + +    R E+++  L+ EQA   RDA  KG+Y RLF +
Sbjct: 354 TAASLLEVNPPDLMSCLTSRTLIT----RGETVSTPLSREQALDVRDAFVKGIYGRLFVW 409

Query: 365 LVEAINRAMQKPQEE------YSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 418
           +V+ IN A+ KP  +       SIG+LDI+GFE F  N FEQ CINF NE LQQ F+   
Sbjct: 410 IVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHV 469

Query: 419 LKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT 478
            K EQEEY  E I W  I++ +N+   D+I NK  P  I+S++D+          G D T
Sbjct: 470 FKLEQEEYDLESIDWLHIEFTDNQDALDMIANK--PMNIISLIDEESKFPK----GTDTT 523

Query: 479 LLQKLQAAVGTHEHF----NSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           +L KL +    + ++    N+    F I+H+AG V Y+  GF E+NRD L  D+I+L+ +
Sbjct: 524 MLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHS 583

Query: 535 SEQAFLRMLFPE--KLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKR 592
           S   F++ +F     +  + + R  T  S+ K+    L+ TL  C P ++RCIKPNE K+
Sbjct: 584 SRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKK 643

Query: 593 PRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWR-GDERQ 651
           P  ++ +    Q+ Y G+ E IR+RRAG+  R  F +F++RY +L P   P ++ GD R 
Sbjct: 644 PMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRG 703

Query: 652 GVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRER-------------------- 691
             Q +  AV    D +Q+G TK+F+K+   + LLE  R++                    
Sbjct: 704 TCQRMAEAVLGTHDDWQIGKTKIFLKDHHDM-LLEVERDKAITDRVILLQKVIRGFKDRS 762

Query: 692 ---KFDGFARTIQKAWRRHVAVRKYEEMR 717
              K    A  IQ+ WR H   + Y  MR
Sbjct: 763 NFLKLKNAATLIQRHWRGHNCRKNYGLMR 791


>gi|153945715 myosin VC [Homo sapiens]
          Length = 1742

 Score =  473 bits (1216), Expect = e-133
 Identities = 282/747 (37%), Positives = 422/747 (56%), Gaps = 43/747 (5%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDD-YIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           G +D+  L  + E A+  NLR RF +   I+TY G +L+++NP+KQ+P + D  I  Y G
Sbjct: 68  GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSG 127

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
               +  PHI+A+ +  Y+ M  +  NQ +I+SGESGAGKTV+A+Y M Y + VS  G  
Sbjct: 128 QNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSN 187

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
             HV+D +L SNP+ EA GNAKT RN+NSSRFGKY EI F    +  G  +S +LLEKSR
Sbjct: 188 A-HVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSR 246

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGET 256
           VV Q+ENERN+HI+YQL   A Q + ++L L + + + Y        ++G +DR++  ET
Sbjct: 247 VVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVET 306

Query: 257 LSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAY--LLGIDS 314
                ++G     Q  V +++A ILHLGN+     GN     S D      +  LLG++S
Sbjct: 307 QKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLES 366

Query: 315 GRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374
           GR+ + L +RK+ +     SE++   +   QA   RDALAK +YA LFDF+VE IN+A+Q
Sbjct: 367 GRVAQWLCNRKIVT----SSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQ 422

Query: 375 KPQEEYS-IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRW 433
              ++++ IGVLDIYGFE F  N FEQFCIN+ NEKLQQ F     K EQEEY++E I W
Sbjct: 423 FSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPW 482

Query: 434 TPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKL-QAAVGTHEH 492
           T I +++N+ V DLIE K+   GI+ +LD+ C   H    G D+  LQKL    V  +  
Sbjct: 483 TLIDFYDNQPVIDLIEAKM---GILELLDEECLLPH----GTDENWLQKLYNNFVNRNPL 535

Query: 493 FNS---WSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEK-- 547
           F      +  FVI H+A KV Y   GF E+NRD ++  L+E+++ S+       F E   
Sbjct: 536 FEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPT 595

Query: 548 -----------------LDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNET 590
                            +  + K   +T GSK +     L+ TL   TPHY+RCIKPN+ 
Sbjct: 596 PPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDE 655

Query: 591 KRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDER 650
           K P +++  R+  Q+   G+ E IR+    +  R  + +F  RY IL  +    +  D++
Sbjct: 656 KLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSF-SDKK 714

Query: 651 QGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAV 710
           +  + +L  +  + +QYQ G TK+F +  +  + LE++R  K       +QK  R  +  
Sbjct: 715 EVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAY-LEKLRLDKLRQSCVMVQKHMRGWLQR 773

Query: 711 RKYEEMREEASNILLNKKERRRNSINR 737
           +K+  +RE  + +++ +  R + ++ +
Sbjct: 774 KKF--LRERRAALIIQQYFRGQQTVRK 798


>gi|122937512 myosin VIIB [Homo sapiens]
          Length = 2116

 Score =  473 bits (1216), Expect = e-133
 Identities = 291/796 (36%), Positives = 431/796 (54%), Gaps = 66/796 (8%)

Query: 12  HNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREI 71
           H     GVDDM+ L  + E  +  NL  R+    I+TY GS+L++VNPF+ +P +T  ++
Sbjct: 60  HPNSVQGVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQV 119

Query: 72  DLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVS 131
            LY      E PPH++A+ +N Y +M  +  +QC IISGESGAGKT   K I+ +++ +S
Sbjct: 120 QLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATIS 179

Query: 132 GGGEKVQH--VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISN 189
           G     QH  ++  +L++NP+LEAFGNAKT+RN+NSSRFGKY +I F+  G  +G +I  
Sbjct: 180 G-----QHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQ 234

Query: 190 FLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDD 249
           FLLEKSRV  Q   ERN+HI+Y +L G S E +Q L L TP  Y+YL   +    +G +D
Sbjct: 235 FLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLND 294

Query: 250 RSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAY- 308
             D+    SAM+++    S    V++L+A ILHLGN+ F     +  +++ D++  PA+ 
Sbjct: 295 AKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFMA-SVFENLDASDVMETPAFP 353

Query: 309 ----LLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDF 364
               LL +    L++ L    +      R E +  +LN+ QAA  RDA  KG+Y  LF +
Sbjct: 354 TVMKLLEVQHQELRDCLIKHTILI----RGEFVTRSLNIAQAADRRDAFVKGIYGHLFLW 409

Query: 365 LVEAINRAMQKPQEE------YSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 418
           +V+ IN A+  P  +       +IG+LDI+GFE F+ N FEQ CINF NE LQQ F++  
Sbjct: 410 IVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHV 469

Query: 419 LKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT 478
              EQEEY  E I W  I Y +N+   DL+   L P  I+S+LD+          G D T
Sbjct: 470 FTMEQEEYRSENISWDYIHYTDNRPTLDLL--ALKPMSIISLLDEESRFPQ----GTDLT 523

Query: 479 LLQKLQAAVGTHEHF----NSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQT 534
           +LQKL +    ++ F    N   A F I H+AG+V Y   GF E+NRDVL +D++ L+ +
Sbjct: 524 MLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYS 583

Query: 535 SEQAFLRMLFPEKL---------------------DGDKKGRPSTAGSKIKKQANDLVAT 573
           S+  FLR +F  +L                       D   RPST GS+ K+  + L+  
Sbjct: 584 SKNKFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKI 643

Query: 574 LMRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQR 633
           L  C P++IRCIKPNE K+P  ++      Q+ Y G+ E + +R++GF  R  F +F QR
Sbjct: 644 LTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQR 703

Query: 634 YAILTPETW-PRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERK 692
           + +L P     + +G  RQ    +          ++ G TK+F+++ +   LLE  R + 
Sbjct: 704 FGVLLPNAMRMQLQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDT-LLEVQRSQV 762

Query: 693 FDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLE----- 747
            D  A +IQK  R +   +++   R  A  +   +   R     RNF    +G E     
Sbjct: 763 LDRAALSIQKVLRGYRYRKEFLRQRRAAVTL---QAWWRGYCNRRNFKLILVGFERLQAI 819

Query: 748 --ERPELRQFLGKRER 761
              +P  RQ+   R+R
Sbjct: 820 ARSQPLARQYQAMRQR 835


>gi|118402590 myosin XV [Homo sapiens]
          Length = 3530

 Score =  463 bits (1191), Expect = e-130
 Identities = 284/737 (38%), Positives = 411/737 (55%), Gaps = 42/737 (5%)

Query: 16   QSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQ 75
            + GV+DM  L  + E  + +NL+ RF  + I+TYIGS+L+SVNP++    +   ++  Y 
Sbjct: 1221 EDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYN 1280

Query: 76   GAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGE 135
            G A  ENPPH++A+ +  +  ML   +NQC+IISGESG+GKT A K I+ Y++ ++   E
Sbjct: 1281 GRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKRE 1340

Query: 136  KVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKS 195
             +Q +K  IL++ PLLE+FGNAKTVRN+NSSRFGK+ EI F  GG   G   S +LLEKS
Sbjct: 1341 VMQQIK--ILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQYLLEKS 1397

Query: 196  RVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGE 255
            R+V Q +NERN+HI+Y+LL G   + RQ   L   + YYYLNQ    ++ G  D  DF  
Sbjct: 1398 RIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRR 1457

Query: 256  TLSAMQVIGIPPSIQQLVLQLVAGILHLGNISF----CEDGNYARVESVDLLAFPAYLLG 311
             L+AM+V+G     Q  + +++A ILHLGN+ F     +    A V S   +   A LL 
Sbjct: 1458 LLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAREIQAVAELLQ 1517

Query: 312  IDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINR 371
            I    LQ+ +T +  ++      E I   L VE A   RDA+AK LYA LF +L+  +N 
Sbjct: 1518 ISPEGLQKAITFKVTET----MREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNA 1573

Query: 372  AMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGI 431
             +   Q+  SI +LDIYGFE    N FEQ CIN+ NE LQ +F ++  + EQEEY++E I
Sbjct: 1574 LVSPRQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQI 1633

Query: 432  RWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHE 491
             W  I + +N+   +LI   L P GI+ +LDD C    AT    D T LQK     G + 
Sbjct: 1634 DWQEITFADNQPCINLI--SLKPYGILRILDDQCCFPQAT----DHTFLQKCHYHHGANP 1687

Query: 492  HFNSWS---AGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLF---- 544
             ++        F I HYAGKV+Y V  F ++N D +  D+++L   S    +  LF    
Sbjct: 1688 LYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHA 1747

Query: 545  ----PEKLDGD----KKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDW 596
                P++L       +  +  T  +K ++   DLV  + RC P ++RC+KPN  K P  +
Sbjct: 1748 PQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLF 1807

Query: 597  EENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILT--PETWPRWRGDERQGVQ 654
            E + V  Q+ Y G+ E +R+R+ GF  R  F  F+ RY  L       P   GD    V 
Sbjct: 1808 EPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPA-NGD--MCVS 1864

Query: 655  HLLRAVNMEPDQYQMGSTKVFVKNPESLF-LLEEVRERKFDGFARTIQKAWRRHVAVRKY 713
             L R   + P+ Y++G +K+F+K  E L+ LLE +RE   +  A T+Q+  R     R++
Sbjct: 1865 VLSRLCKVMPNMYRVGVSKLFLK--EHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRF 1922

Query: 714  EEMREEASNILLNKKER 730
              +R +   ILL  + R
Sbjct: 1923 RSLRHKI--ILLQSRAR 1937


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score =  458 bits (1179), Expect = e-128
 Identities = 290/753 (38%), Positives = 425/753 (56%), Gaps = 48/753 (6%)

Query: 12  HNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMP-YFTDRE 70
           H   + GVDDM  L ++   +I  NL +R+  + I+TYIGS+L SVNP++ +   +    
Sbjct: 58  HPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPAT 117

Query: 71  IDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKV 130
           ++ Y      E PPHI+A+ +  YR +    +NQC++ISGESGAGKT + K I+ ++S +
Sbjct: 118 MEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVI 177

Query: 131 SGGG------EKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDG 184
           S         EK   V+  IL+S+P++EAFGNAKTV NNNSSRFGK+ ++   + G   G
Sbjct: 178 SQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQG 237

Query: 185 GKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQV 244
           G+I ++LLEK+RVV QN  ERN+HI+Y LL G   E+R+   L TP+ Y+YLNQS   + 
Sbjct: 238 GRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYHYLNQSGCVED 297

Query: 245 DGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLA 304
               D+  F E ++AM V+       + V +L+AGILHLGNI F   G  A+V     L 
Sbjct: 298 KTISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEFITAGG-AQVSFKTALG 356

Query: 305 FPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDF 364
             A LLG+D  +L + LT R M      R E I   LNV+QA  +RD+LA  LYA  F++
Sbjct: 357 RSAELLGLDPTQLTDALTQRSMFL----RGEEILTPLNVQQAVDSRDSLAMALYACCFEW 412

Query: 365 LVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQE 424
           +++ IN  ++  ++  SIG+LDI+GFE F+ N FEQF IN+ NEKLQ+ F +     EQ 
Sbjct: 413 VIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQL 472

Query: 425 EYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQ 484
           EY +EG+ W  I + +N    DLIE KL   G+++++++      AT    D TLL+KL 
Sbjct: 473 EYSREGLVWEDIDWIDNGECLDLIEKKL---GLLALINEESHFPQAT----DSTLLEKLH 525

Query: 485 AA-VGTHEHFNSWSA--GFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLR 541
           +     H +     A   F + HYAG+V YDV G  E+NRD    DL+ L++ S   F+ 
Sbjct: 526 SQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIY 585

Query: 542 MLF--------PEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRP 593
            LF         + L    K R  T  S+ K   + L+ATL    P ++RCIKPN  K P
Sbjct: 586 DLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMP 645

Query: 594 RDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAIL-----TPETWPRWRGD 648
             +++  V +Q+ Y G+ E +R+R+AG+A RR F  F +RY +L      PE       D
Sbjct: 646 DQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPE-------D 698

Query: 649 ERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESL-FLLEEVRERKFDGFARTIQKAWRRH 707
            R     LL+  +    ++Q+G TKVF++  ESL   LE+ RE +    A  I+      
Sbjct: 699 VRGKCTSLLQLYDASNSEWQLGKTKVFLR--ESLEQKLEKRREEEVSHAAMVIRAHVLGF 756

Query: 708 VAVRKYEEMREEASNILLNKKERRRNSINRNFV 740
           +A ++Y   R+    +++ +K  R   + R F+
Sbjct: 757 LARKQY---RKVLYCVVIIQKNYRAFLLRRRFL 786


>gi|122937345 myosin VB [Homo sapiens]
          Length = 1848

 Score =  457 bits (1176), Expect = e-128
 Identities = 270/772 (34%), Positives = 426/772 (55%), Gaps = 68/772 (8%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMD-DYIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           G +D+  L  + E A+  NL+ RF++ ++I+TY G VL+++NP++Q+P +    I  Y G
Sbjct: 70  GENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSG 129

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
               +  PHI+A+ +  Y+ M  D +NQ +I+SGESGAGKTV+AKY M Y + V GG   
Sbjct: 130 QNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATV-GGSAS 188

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
             ++++ +L S+P++EA GNAKT RN+NSSRFGKY +I F +     G  +  +LLEKSR
Sbjct: 189 ETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSR 248

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGET 256
           VV Q ++ERN+HI+YQL   A   + + L L + + ++Y +Q     ++G DD  DF +T
Sbjct: 249 VVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKT 308

Query: 257 LSAMQVIGIPPSIQQLVLQLVAGILHLGNISFC--EDGNYARVESVDL-LAFPAYLLGID 313
             A  ++G+  S Q  + +++A ILHLG+++     DG+   +   D+ L+    LLG++
Sbjct: 309 RQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVE 368

Query: 314 SGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373
             +++  L  RK+ +     SE+   T++++Q    R+ALAK +YA+LF ++VE IN+A+
Sbjct: 369 HSQMEHWLCHRKLVT----TSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKAL 424

Query: 374 QKPQEEYS-IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIR 432
               +++S IGVLDIYGFE F+ N FEQFCIN+ NEKLQQ F     K EQEEY++E I 
Sbjct: 425 HTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIP 484

Query: 433 WTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEH 492
           WT I +++N+   DLIE KL   GI+ +LD+ C        G DQ   QKL     + +H
Sbjct: 485 WTLIDFYDNQPCIDLIEAKL---GILDLLDEECKVPK----GTDQNWAQKLYDRHSSSQH 537

Query: 493 FNS---WSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLD 549
           F      +  F+I H+A KV Y   GF E+NRD ++ + I +++ S+   +  LF +  D
Sbjct: 538 FQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKD 597

Query: 550 G-------------------------DKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRC 584
                                       K    T G + +   + L+ TL   TPHY+RC
Sbjct: 598 PVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRC 657

Query: 585 IKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPR 644
           IKPN+ K P  ++  R   Q+   G+ E IR+  AG+  R  +  F  RY +L  +    
Sbjct: 658 IKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKR-EL 716

Query: 645 WRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFL-------------------- 684
              D++   + +L  +  +PD++Q G TK+F +  +  +L                    
Sbjct: 717 ANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVR 776

Query: 685 --LEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNS 734
             L++V+  +  G   T+Q+  R H+A R  E +R   + ++L K  R + +
Sbjct: 777 GWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRA 828


>gi|215982794 myosin VA isoform 2 [Homo sapiens]
          Length = 1828

 Score =  455 bits (1171), Expect = e-128
 Identities = 278/742 (37%), Positives = 413/742 (55%), Gaps = 57/742 (7%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDD-YIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           G +D+  L  + E A+  NLR RF+D   I+TY G VL+++NP++Q+P + +  I+ Y G
Sbjct: 70  GENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
               +  PHI+A+ +  Y+ M  D  NQ +I+SGESGAGKTV+AKY M Y + VSG   +
Sbjct: 130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASE 189

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
             +V++ +L SNP++E+ GNAKT RN+NSSRFGKY EI F +     G  +  +LLEKSR
Sbjct: 190 A-NVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSR 248

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGET 256
           VV Q E ERN+HI+YQL   A   + + L L   D + Y  Q  +  ++G DD  +   T
Sbjct: 249 VVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHT 308

Query: 257 LSAMQVIGIPPSIQQLVLQLVAGILHLGNISF-CEDGNYARV-ESVDLLAFPAYLLGIDS 314
             A  ++GI  S Q  + +++AGILHLGN+ F   D +   +    + L     L+G+D 
Sbjct: 309 RQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCDLMGVDY 368

Query: 315 GRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374
             +   L  RK+ +     +E+    ++  QA   RDALAK +YA+LF+++V+ +N+A+ 
Sbjct: 369 EEMCHWLCHRKLAT----ATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALH 424

Query: 375 KPQEEYS-IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRW 433
              +++S IGVLDIYGFE F+ N FEQFCIN+ NEKLQQ F     K EQEEY++E I W
Sbjct: 425 SAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW 484

Query: 434 TPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTH--- 490
           T I +++N+   +LIE+KL   GI+ +LD+ C        G D T  QKL     TH   
Sbjct: 485 TLIDFYDNQPCINLIESKL---GILDLLDEECKMPK----GTDDTWAQKL---YNTHLNK 534

Query: 491 ----EHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPE 546
               E     +  F+I H+A KV Y   GF E+N+D +F + I+++++S+   L  LF +
Sbjct: 535 CALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQD 594

Query: 547 KLDG--------------------DKKGRP--------STAGSKIKKQANDLVATLMRCT 578
                                     KGRP         T G + +   + L+ TL   T
Sbjct: 595 DEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATT 654

Query: 579 PHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILT 638
           PHY+RCIKPN+ K P  ++E R   Q+   G+ E IR+  AGF  R  + +F  RY +L 
Sbjct: 655 PHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLM 714

Query: 639 PETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFAR 698
            +       D +Q  +++L  + ++ D+YQ G TK+F +  +  + LE++R  K      
Sbjct: 715 KQ--KDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAY-LEKLRADKLRAACI 771

Query: 699 TIQKAWRRHVAVRKYEEMREEA 720
            IQK  R  +  +KY  MR+ A
Sbjct: 772 RIQKTIRGWLLRKKYLRMRKAA 793


>gi|215982791 myosin VA isoform 1 [Homo sapiens]
          Length = 1855

 Score =  455 bits (1171), Expect = e-128
 Identities = 278/742 (37%), Positives = 413/742 (55%), Gaps = 57/742 (7%)

Query: 18  GVDDMVLLPQITEDAIAANLRKRFMDD-YIFTYIGSVLISVNPFKQMPYFTDREIDLYQG 76
           G +D+  L  + E A+  NLR RF+D   I+TY G VL+++NP++Q+P + +  I+ Y G
Sbjct: 70  GENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129

Query: 77  AAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEK 136
               +  PHI+A+ +  Y+ M  D  NQ +I+SGESGAGKTV+AKY M Y + VSG   +
Sbjct: 130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASE 189

Query: 137 VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSR 196
             +V++ +L SNP++E+ GNAKT RN+NSSRFGKY EI F +     G  +  +LLEKSR
Sbjct: 190 A-NVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSR 248

Query: 197 VVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGET 256
           VV Q E ERN+HI+YQL   A   + + L L   D + Y  Q  +  ++G DD  +   T
Sbjct: 249 VVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHT 308

Query: 257 LSAMQVIGIPPSIQQLVLQLVAGILHLGNISF-CEDGNYARV-ESVDLLAFPAYLLGIDS 314
             A  ++GI  S Q  + +++AGILHLGN+ F   D +   +    + L     L+G+D 
Sbjct: 309 RQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCDLMGVDY 368

Query: 315 GRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374
             +   L  RK+ +     +E+    ++  QA   RDALAK +YA+LF+++V+ +N+A+ 
Sbjct: 369 EEMCHWLCHRKLAT----ATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALH 424

Query: 375 KPQEEYS-IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRW 433
              +++S IGVLDIYGFE F+ N FEQFCIN+ NEKLQQ F     K EQEEY++E I W
Sbjct: 425 SAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW 484

Query: 434 TPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTH--- 490
           T I +++N+   +LIE+KL   GI+ +LD+ C        G D T  QKL     TH   
Sbjct: 485 TLIDFYDNQPCINLIESKL---GILDLLDEECKMPK----GTDDTWAQKL---YNTHLNK 534

Query: 491 ----EHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPE 546
               E     +  F+I H+A KV Y   GF E+N+D +F + I+++++S+   L  LF +
Sbjct: 535 CALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQD 594

Query: 547 KLDG--------------------DKKGRP--------STAGSKIKKQANDLVATLMRCT 578
                                     KGRP         T G + +   + L+ TL   T
Sbjct: 595 DEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATT 654

Query: 579 PHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILT 638
           PHY+RCIKPN+ K P  ++E R   Q+   G+ E IR+  AGF  R  + +F  RY +L 
Sbjct: 655 PHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLM 714

Query: 639 PETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFAR 698
            +       D +Q  +++L  + ++ D+YQ G TK+F +  +  + LE++R  K      
Sbjct: 715 KQ--KDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAY-LEKLRADKLRAACI 771

Query: 699 TIQKAWRRHVAVRKYEEMREEA 720
            IQK  R  +  +KY  MR+ A
Sbjct: 772 RIQKTIRGWLLRKKYLRMRKAA 793


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  433 bits (1114), Expect = e-121
 Identities = 265/737 (35%), Positives = 410/737 (55%), Gaps = 42/737 (5%)

Query: 15  KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY 74
           K S V+DM  L  + E ++  NL++R+    I+TY G   + +NP+K +P +++  +++Y
Sbjct: 79  KFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMY 138

Query: 75  QGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGG 134
           +G  ++E PPHIYA+TD  YR+M+ D E+Q ++ +GESGAGKT   K ++ Y++ V+   
Sbjct: 139 KGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSH 198

Query: 135 EKVQHVKDI---ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFL 191
           +  +   ++   +LQ+NP+LEAFGNAKTV+N+NSSRFGK+  I F   G   G  I  +L
Sbjct: 199 KSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYL 258

Query: 192 LEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRS 251
           LEKSR + Q + ER FHI+Y LL GA +  + +L L   + Y +L+      + G  D+ 
Sbjct: 259 LEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHV-TIPGQQDKD 317

Query: 252 DFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP--AYL 309
            F ET+ AM+++GIP   Q  +L++++G+L LGNI F ++ N  +    D  A    ++L
Sbjct: 318 MFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHL 377

Query: 310 LGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAI 369
           LGI+       + + ++     GR + +      EQA +  +ALAK  Y R+F +LV  I
Sbjct: 378 LGINVTDFTRGILTPRIKV---GR-DYVQKAQTKEQADFAIEALAKATYERMFRWLVLRI 433

Query: 370 NRAMQKPQEEYS--IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYV 427
           N+A+ K + + +  IG+LDI GFEIF  N FEQ CIN+ NEKLQQ+F       EQEEY 
Sbjct: 434 NKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQ 493

Query: 428 QEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAA 486
           +EGI W  I +  +   C DLIE    PPGI+++LD+ C    AT    D++ ++K+   
Sbjct: 494 REGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKAT----DKSFVEKVMQE 549

Query: 487 VGTHEHFN-----SWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLR 541
            GTH  F         A F I HYAGKV Y    +  +N D L  ++  L+  S   F+ 
Sbjct: 550 QGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVS 609

Query: 542 MLFPE----------------KLDG---DKKGRPSTAGSKIKKQANDLVATLMRCTPHYI 582
            L+ +                 L G    +KG   T G   K+Q   L+ATL    P+++
Sbjct: 610 ELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFV 669

Query: 583 RCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETW 642
           RCI PN  K+    + + V  Q+   G+ E IR+ R GF  R  F +F QRY ILTP + 
Sbjct: 670 RCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSI 729

Query: 643 PRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQK 702
           P+   D +Q    +++A+ ++ + Y++G +KVF +    L  LEE R+ K        Q 
Sbjct: 730 PKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFR-AGVLAHLEEERDLKITDVIIGFQA 788

Query: 703 AWRRHVAVRKYEEMREE 719
             R ++A + + + +++
Sbjct: 789 CCRGYLARKAFAKRQQQ 805


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
           sapiens]
          Length = 1935

 Score =  431 bits (1108), Expect = e-120
 Identities = 284/800 (35%), Positives = 423/800 (52%), Gaps = 46/800 (5%)

Query: 4   KERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQM 63
           KE    Q +  K   ++DM +L  + E A+  NL+ R+    I+TY G   ++VNP+K +
Sbjct: 72  KEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWL 131

Query: 64  PYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYI 123
           P +T   +  Y+G  + E PPHI++++DN Y+ ML D ENQ ++I+GESGAGKTV  K +
Sbjct: 132 PVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRV 191

Query: 124 MGYISKVSGGGEKVQH--------VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQ 175
           + Y + ++  G++ +         ++D I+Q+NP LEAFGNAKTVRN+NSSRFGK+  I 
Sbjct: 192 IQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIH 251

Query: 176 FSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDY-YY 234
           F   G+     I  +LLEKSRV+ Q + ER++HI+YQ+L     E    L +    Y Y 
Sbjct: 252 FGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYA 311

Query: 235 YLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISF--CEDG 292
           +++Q +T  V   DD  +   T +A  V+G     +  + +L   I+H GN+ F   +  
Sbjct: 312 FISQGET-TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE 370

Query: 293 NYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDA 352
             A  +  +     AYL+G++S  L + L   ++       +E +    NV+Q  Y   A
Sbjct: 371 EQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKV----GNEYVTKGQNVQQVIYATGA 426

Query: 353 LAKGLYARLFDFLVEAINRAMQ-KPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQ 411
           LAK +Y R+F+++V  IN  ++ K   +Y IGVLDI GFEIF  N FEQ CINF NEKLQ
Sbjct: 427 LAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQ 486

Query: 412 QIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHA 470
           Q F       EQEEY +EGI WT I +  +   C DLIE    P GIMS+L++ C    A
Sbjct: 487 QFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE---KPMGIMSILEEECMFPKA 543

Query: 471 TGGGADQTLLQKL-QAAVGTHEHF-------NSWSAGFVIHHYAGKVSYDVSGFCERNRD 522
           T    D T   KL    +G   +F           A F + HYAG V Y++ G+ ++N+D
Sbjct: 544 T----DMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKD 599

Query: 523 VLFSDLIELMQTSEQAFLRMLFPEKLDGD----------KKGRP-STAGSKIKKQANDLV 571
            L   ++ L Q S    L  LF      D          KKG    T  +  ++  N L+
Sbjct: 600 PLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLM 659

Query: 572 ATLMRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFL 631
             L    PH++RCI PNETK P   +   V HQ+   G+ E IR+ R GF  R  +  F 
Sbjct: 660 TNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 719

Query: 632 QRYAILTPETWPRWRG-DERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRE 690
           QRY IL P   P  +  D R+G + LL +++++ +QY+ G TKVF K    L LLEE+R+
Sbjct: 720 QRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRD 778

Query: 691 RKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERP 750
            +       IQ   R  +A  +Y+++ E   ++L+ +   R     +N+    L  + +P
Sbjct: 779 ERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKP 838

Query: 751 ELRQFLGKRERVDFADSVTK 770
            L+    ++E     +  T+
Sbjct: 839 LLKSAEREKEMASMKEEFTR 858


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  428 bits (1100), Expect = e-119
 Identities = 265/742 (35%), Positives = 412/742 (55%), Gaps = 45/742 (6%)

Query: 15  KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY 74
           K S V+DM  L  + E ++  NL+ R+    I+TY G   + +NP+K +P +++  I++Y
Sbjct: 83  KFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMY 142

Query: 75  QGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGG- 133
           +G  ++E PPHIYA++++ YR ML D E+Q ++ +GESGAGKT   K ++ Y++ V+   
Sbjct: 143 RGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSH 202

Query: 134 -GEKVQHV----KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKIS 188
            G K  ++    +  +LQ+NP+LE+FGNAKTV+N+NSSRFGK+  I F   G   G  I 
Sbjct: 203 KGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIE 262

Query: 189 NFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTD 248
            +LLEKSR V Q ++ER FHI+YQLL GA +  + +L L   + Y +L+ +    + G  
Sbjct: 263 TYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLS-NGYIPIPGQQ 321

Query: 249 DRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGN--YARVESVDLLAFP 306
           D+ +F ET+ AM ++G        +L++V+ +L  GNISF ++ N   A +    +    
Sbjct: 322 DKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKL 381

Query: 307 AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLV 366
            +LLG++       + + ++     GR + +      EQA +  +ALAK  Y RLF +LV
Sbjct: 382 CHLLGMNVMEFTRAILTPRIKV---GR-DYVQKAQTKEQADFAVEALAKATYERLFRWLV 437

Query: 367 EAINRAMQKPQEEYS--IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQE 424
             IN+A+ + + + +  IG+LDI GFEIF+ N FEQ CIN+ NEKLQQ+F       EQE
Sbjct: 438 HRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQE 497

Query: 425 EYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKL 483
           EY +EGI W  I +  +   C DLIE   +PPG++++LD+ C    AT    D+T ++KL
Sbjct: 498 EYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKAT----DKTFVEKL 553

Query: 484 QAAVGTHEHFN-----SWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA 538
               G+H  F         A F I HYAGKV Y    +  +N D L  ++  L+  S   
Sbjct: 554 VQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDR 613

Query: 539 FLRMLFP--EKLDG-----------------DKKGRPSTAGSKIKKQANDLVATLMRCTP 579
           F+  L+   +++ G                  KKG   T G   K+    L+ATL    P
Sbjct: 614 FVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNP 673

Query: 580 HYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTP 639
           +++RCI PN  KR    + + V  Q+   G+ E IR+ R GF  R  F +F QRY ILTP
Sbjct: 674 NFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTP 733

Query: 640 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 699
              P+   D +Q  + ++RA+ ++P+ Y++G +K+F +    L  LEE R+ K       
Sbjct: 734 NAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFR-AGVLAHLEEERDLKITDIIIF 792

Query: 700 IQKAWRRHVAVRKYEEMREEAS 721
            Q   R ++A + + + +++ S
Sbjct: 793 FQAVCRGYLARKAFAKKQQQLS 814


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
           sapiens]
          Length = 1972

 Score =  420 bits (1080), Expect = e-117
 Identities = 258/740 (34%), Positives = 403/740 (54%), Gaps = 45/740 (6%)

Query: 15  KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY 74
           K S V+DM  L  + E ++  NLR+R+    I+TY G   + VNP+K +P ++++ +D+Y
Sbjct: 83  KFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMY 142

Query: 75  QGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGG- 133
           +G  ++E PPHIYA+ D  YR+ML D E+Q ++ +GESGAGKT   K ++ Y++ V+   
Sbjct: 143 KGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSH 202

Query: 134 -GEK----VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKIS 188
            G+K       ++  +LQ+NP+LEAFGNAKTV+N+NSSRFGK+  I F   G   G  I 
Sbjct: 203 KGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIE 262

Query: 189 NFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTD 248
            +LLEKSR + Q  +ER FHI+Y ++ GA ++ R +L L   + Y +L+ +    +    
Sbjct: 263 TYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLS-NGFVPIPAAQ 321

Query: 249 DRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP-- 306
           D   F ET+ AM ++G     Q  +L++V+ +L LGNI F ++ N  +    D  A    
Sbjct: 322 DDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKV 381

Query: 307 AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLV 366
            +L+GI+       + + ++     GR + +      EQA +  +ALAK  Y RLF +++
Sbjct: 382 CHLMGINVTDFTRSILTPRIKV---GR-DVVQKAQTKEQADFAVEALAKATYERLFRWIL 437

Query: 367 EAINRAMQKPQEEYS--IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQE 424
             +N+A+ K   + +  +G+LDI GFEIF+ N FEQ CIN+ NEKLQQ+F       EQE
Sbjct: 438 TRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQE 497

Query: 425 EYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKL 483
           EY +EGI W  I +  +   C +LIE   +PPG++++LD+ C    AT    D++ ++KL
Sbjct: 498 EYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKAT----DKSFVEKL 553

Query: 484 QAAVGTHEHFN-----SWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA 538
               G+H  F           F I HYAGKV Y+ S +  +N D L  ++  L+  S   
Sbjct: 554 CTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDK 613

Query: 539 FLRMLFPE-------------------KLDGDKKGRPSTAGSKIKKQANDLVATLMRCTP 579
           F+  L+ +                        KKG   T G   K+Q   L+ TL   TP
Sbjct: 614 FVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTP 673

Query: 580 HYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTP 639
           +++RCI PN  KR    +   V  Q+   G+ E IR+ R GF  R  F +F QRY IL  
Sbjct: 674 NFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAA 733

Query: 640 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 699
              P+   D +Q    +++A+ ++P+ Y++G +K+F +    L  LEE R+ K       
Sbjct: 734 NAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRT-GVLAHLEEERDLKITDVIMA 792

Query: 700 IQKAWRRHVAVRKYEEMREE 719
            Q   R ++A + + + +++
Sbjct: 793 FQAMCRGYLARKAFAKRQQQ 812


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
           sapiens]
          Length = 1938

 Score =  420 bits (1080), Expect = e-117
 Identities = 258/740 (34%), Positives = 403/740 (54%), Gaps = 45/740 (6%)

Query: 15  KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY 74
           K S V+DM  L  + E ++  NLR+R+    I+TY G   + VNP+K +P ++++ +D+Y
Sbjct: 83  KFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMY 142

Query: 75  QGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGG- 133
           +G  ++E PPHIYA+ D  YR+ML D E+Q ++ +GESGAGKT   K ++ Y++ V+   
Sbjct: 143 KGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSH 202

Query: 134 -GEK----VQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKIS 188
            G+K       ++  +LQ+NP+LEAFGNAKTV+N+NSSRFGK+  I F   G   G  I 
Sbjct: 203 KGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIE 262

Query: 189 NFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTD 248
            +LLEKSR + Q  +ER FHI+Y ++ GA ++ R +L L   + Y +L+ +    +    
Sbjct: 263 TYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLS-NGFVPIPAAQ 321

Query: 249 DRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP-- 306
           D   F ET+ AM ++G     Q  +L++V+ +L LGNI F ++ N  +    D  A    
Sbjct: 322 DDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKV 381

Query: 307 AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLV 366
            +L+GI+       + + ++     GR + +      EQA +  +ALAK  Y RLF +++
Sbjct: 382 CHLMGINVTDFTRSILTPRIKV---GR-DVVQKAQTKEQADFAVEALAKATYERLFRWIL 437

Query: 367 EAINRAMQKPQEEYS--IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQE 424
             +N+A+ K   + +  +G+LDI GFEIF+ N FEQ CIN+ NEKLQQ+F       EQE
Sbjct: 438 TRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQE 497

Query: 425 EYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKL 483
           EY +EGI W  I +  +   C +LIE   +PPG++++LD+ C    AT    D++ ++KL
Sbjct: 498 EYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKAT----DKSFVEKL 553

Query: 484 QAAVGTHEHFN-----SWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA 538
               G+H  F           F I HYAGKV Y+ S +  +N D L  ++  L+  S   
Sbjct: 554 CTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDK 613

Query: 539 FLRMLFPE-------------------KLDGDKKGRPSTAGSKIKKQANDLVATLMRCTP 579
           F+  L+ +                        KKG   T G   K+Q   L+ TL   TP
Sbjct: 614 FVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTP 673

Query: 580 HYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTP 639
           +++RCI PN  KR    +   V  Q+   G+ E IR+ R GF  R  F +F QRY IL  
Sbjct: 674 NFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAA 733

Query: 640 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 699
              P+   D +Q    +++A+ ++P+ Y++G +K+F +    L  LEE R+ K       
Sbjct: 734 NAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRT-GVLAHLEEERDLKITDVIMA 792

Query: 700 IQKAWRRHVAVRKYEEMREE 719
            Q   R ++A + + + +++
Sbjct: 793 FQAMCRGYLARKAFAKRQQQ 812


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  419 bits (1078), Expect = e-117
 Identities = 269/750 (35%), Positives = 397/750 (52%), Gaps = 46/750 (6%)

Query: 10  QSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDR 69
           Q +  K   ++DM +L  + E A+  NL++R+    I+TY G   ++VNP+K +P +   
Sbjct: 78  QQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAE 137

Query: 70  EIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISK 129
            +  Y+G  + E PPHI++++DN Y+ ML D ENQ ++I+GESGAGKTV  K ++ Y + 
Sbjct: 138 VVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAS 197

Query: 130 VSGGGEKVQH---------VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 180
           ++  G++ +          ++D I+Q+NP LEAFGNAKTVRN+NSSRFGK+  I F   G
Sbjct: 198 IAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257

Query: 181 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 240
           +     I  +LLEKSRV+ Q + ERN+HI+YQ+L     E    L +    Y Y      
Sbjct: 258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQG 317

Query: 241 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCED--GNYARVE 298
              V   DD  +   T SA  V+G     +  V +L   I+H GN+ F +      A  +
Sbjct: 318 EVSVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPD 377

Query: 299 SVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLY 358
             +     AYL+G++S  L + L   ++       +E +    +V+Q  Y+  ALAK +Y
Sbjct: 378 GTEDADKSAYLMGLNSADLLKGLCHPRVKV----GNEYVTKGQSVQQVYYSIGALAKAVY 433

Query: 359 ARLFDFLVEAINRAMQ-KPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIEL 417
            ++F+++V  IN  ++ K   +Y IGVLDI GFEIF  N FEQ CINF NEKLQQ F   
Sbjct: 434 EKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493

Query: 418 TLKAEQEEYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGAD 476
               EQEEY +EGI WT I +  +   C DLIE    P GIMS+L++ C    AT    D
Sbjct: 494 MFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE---KPMGIMSILEEECMFPKAT----D 546

Query: 477 QTLLQKL-QAAVGTHEHF-------NSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDL 528
            T   KL    +G   +F           A F + HYAG V Y++ G+ E+N+D L   +
Sbjct: 547 MTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETV 606

Query: 529 IELMQTSEQAFLRMLFP-----------EKLDGDKKGRP-STAGSKIKKQANDLVATLMR 576
           + L Q S    +  LF            +   G KKG    T  +  ++  N L+  L  
Sbjct: 607 VALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTNLRT 666

Query: 577 CTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAI 636
             PH++RCI PNE K P   +   V HQ+   G+ E IR+ R GF  R  +  F QRY I
Sbjct: 667 THPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726

Query: 637 LTPETWPRWRG-DERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDG 695
           L P   P  +  D R+G + LL +++++ +QY+ G TKVF K    L LLEE+R+ +   
Sbjct: 727 LNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRDERLSR 785

Query: 696 FARTIQKAWRRHVAVRKYEEMREEASNILL 725
               +Q   R  +   +++++ E    +L+
Sbjct: 786 IITRMQAQARGQLMRIEFKKIVERRDALLV 815


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  419 bits (1077), Expect = e-117
 Identities = 265/740 (35%), Positives = 407/740 (55%), Gaps = 44/740 (5%)

Query: 15  KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY 74
           K S  +DM  L  + E ++  NLR+R+    I+TY G   + +NP+KQ+P +T+  +++Y
Sbjct: 103 KFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMY 162

Query: 75  QGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGG- 133
           +G  ++E PPH+YA+T+  YR+ML D E+Q ++ +GESGAGKT   K ++ Y++ V+   
Sbjct: 163 RGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSP 222

Query: 134 -GEKVQHV----KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKIS 188
            G K   V    +  +LQ+NP+LEAFGNAKTV+N+NSSRFGK+  I F   G   G  I 
Sbjct: 223 KGRKEPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIE 282

Query: 189 NFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTD 248
            +LLEKSR + Q ++E +FHI+YQLL GA ++ + +L L    +Y +L    +       
Sbjct: 283 TYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPG--Q 340

Query: 249 DRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFP-- 306
           +R  F ETL +++V+G        +L++V+ +L  GNI+   + N  +    D  A    
Sbjct: 341 ERELFQETLESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL 400

Query: 307 AYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLV 366
             LLG+        L + ++     GR + +      EQA +  +ALAK  Y RLF +LV
Sbjct: 401 CRLLGLGVTDFSRALLTPRIKV---GR-DYVQKAQTKEQADFALEALAKATYERLFRWLV 456

Query: 367 EAINRAMQK-PQEEYS-IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQE 424
             +NRA+ + P++  S +G+LDI GFEIFQ N FEQ CIN+ NEKLQQ+F       EQE
Sbjct: 457 LRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQE 516

Query: 425 EYVQEGIRWTPIQYFNNKVVC-DLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKL 483
           EY +EGI WT + +  +   C DLIE   +PPG++++LD+ C    AT    D++ ++K+
Sbjct: 517 EYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKAT----DKSFVEKV 572

Query: 484 QAAVGTHEHFN-----SWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA 538
               G H  F         A F + HYAGKV Y  + +  +N D L  ++  L+  S   
Sbjct: 573 AQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDR 632

Query: 539 FLRMLFPEKL------------DGDKKGRP-----STAGSKIKKQANDLVATLMRCTPHY 581
               ++ +              DG   GRP      T G   K+  + L+ATL    P +
Sbjct: 633 LTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSF 692

Query: 582 IRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPET 641
           +RCI PN  KR    E   V  Q+   G+ E IR+ R GF  R  F +F QRY ILTP  
Sbjct: 693 VRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNA 752

Query: 642 WPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQ 701
            P+   D +Q  + +++A+ ++P+ Y++G +K+F +    L  LEE R+ K      + Q
Sbjct: 753 IPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR-AGVLAQLEEERDLKVTDIIVSFQ 811

Query: 702 KAWRRHVAVRKYEEMREEAS 721
            A R ++A R +++ +++ S
Sbjct: 812 AAARGYLARRAFQKRQQQQS 831


>gi|92859701 myosin VI [Homo sapiens]
          Length = 1285

 Score =  419 bits (1076), Expect = e-116
 Identities = 266/736 (36%), Positives = 398/736 (54%), Gaps = 63/736 (8%)

Query: 19  VDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMP-YFTDREIDLYQGA 77
           V+D   L  + E  +  N++ R+  D I+TY+ ++LI+VNP+  +P  ++   I  YQG 
Sbjct: 59  VEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGK 118

Query: 78  AQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKV 137
           +    PPH++A+ D  +R+M +   +Q +I+SGESGAGKT   K+++ Y+++  G G   
Sbjct: 119 SLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTG--- 175

Query: 138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRV 197
           Q + D I+++NPLLEAFGNAKTVRNNNSSRFGK+ EI F+      GG +S++LLEKSR+
Sbjct: 176 QDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRI 235

Query: 198 VMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLN-------------------- 237
            +Q + ERN+HI+Y+L  GAS++ R+ L L +PD + YLN                    
Sbjct: 236 CVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNR 295

Query: 238 QSDTYQVDGT------DDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCED 291
           +S  Y   G+      DD  DF    +AM+ IG+    +  + ++VAG+LHLGNI F E 
Sbjct: 296 KSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEA 355

Query: 292 GNYA-----RVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGG-RSESINVTLNVEQ 345
           G+ +     + +S   L + A LLG+D   L+  LT+R M +  GG +   I V L VEQ
Sbjct: 356 GSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQ 415

Query: 346 AAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINF 405
           A   RDALAK +Y+ LFD +V  +N+        Y IGVLDI GFE F+ N FEQFCIN+
Sbjct: 416 ANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINY 475

Query: 406 VNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDD-- 463
            NEKLQQ F E  LK EQE Y +EG+    + Y +N+   DLIE KL   GI+ +LD+  
Sbjct: 476 CNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKL--VGILDILDEEN 533

Query: 464 ---VCATMHATGGGADQ-------TLLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDV 513
                +  H T     +       T+ +K + AV  H +      GF+I H+AG V Y+ 
Sbjct: 534 RLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAV--HRNIRD-DEGFIIRHFAGAVCYET 590

Query: 514 SGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPS-------TAGSKIKKQ 566
           + F E+N D L   L  L+  S   F+R LF    + +K  +         + G+K K Q
Sbjct: 591 TQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQ 650

Query: 567 ANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQ 626
            N L+  L      +IRCIKPN       +E  ++  Q++  G+   + + + G+  R  
Sbjct: 651 LNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRAS 710

Query: 627 FAKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLE 686
           F +    Y    P+   R   D R   + L +A+ +  + Y+ G TKVF + P      +
Sbjct: 711 FHELYNMYKKYMPDKLARL--DPRLFCKALFKALGLNENDYKFGLTKVFFR-PGKFAEFD 767

Query: 687 EVRERKFDGFARTIQK 702
           ++ +   D  A  +++
Sbjct: 768 QIMKSDPDHLAELVKR 783


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,635,378
Number of Sequences: 37866
Number of extensions: 2190507
Number of successful extensions: 9627
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 257
Number of HSP's successfully gapped in prelim test: 361
Number of HSP's that attempted gapping in prelim test: 8018
Number of HSP's gapped (non-prelim): 1393
length of query: 1098
length of database: 18,247,518
effective HSP length: 113
effective length of query: 985
effective length of database: 13,968,660
effective search space: 13759130100
effective search space used: 13759130100
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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