Search of human proteins with 27436920

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
         (1307 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]      2587   0.0  
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]     2577   0.0  
gi|94557295 mitogen-activated protein kinase 8 interacting prote...  1389   0.0  
gi|94557297 mitogen-activated protein kinase 8 interacting prote...  1387   0.0  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   156   1e-37
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...   103   1e-21
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...   103   1e-21
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...    99   2e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    72   3e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     69   3e-11
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           69   4e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    67   1e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    67   1e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    67   1e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    67   1e-10
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       66   2e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    65   3e-10
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    64   7e-10
gi|148746195 trichohyalin [Homo sapiens]                               63   2e-09
gi|55770834 centromere protein F [Homo sapiens]                        62   3e-09
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              62   3e-09
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]                    61   6e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    61   8e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    61   8e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   60   1e-08
gi|38044112 restin isoform b [Homo sapiens]                            60   1e-08
gi|4506751 restin isoform a [Homo sapiens]                             60   1e-08
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    59   3e-08
gi|71061468 centromere protein E [Homo sapiens]                        59   4e-08
gi|115511012 coiled-coil domain containing 136 [Homo sapiens]          58   7e-08

>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score = 2587 bits (6705), Expect = 0.0
 Identities = 1307/1307 (100%), Positives = 1307/1307 (100%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240
            QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240

Query: 241  RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS 300
            RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS
Sbjct: 241  RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS 300

Query: 301  KHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA 360
            KHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA
Sbjct: 301  KHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA 360

Query: 361  FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDL 420
            FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDL
Sbjct: 361  FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDL 420

Query: 421  IAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD 480
            IAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD
Sbjct: 421  IAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD 480

Query: 481  IPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ 540
            IPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ
Sbjct: 481  IPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ 540

Query: 541  FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET 600
            FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET
Sbjct: 541  FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET 600

Query: 601  EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVY 660
            EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVY
Sbjct: 601  EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVY 660

Query: 661  LRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSL 720
            LRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSL
Sbjct: 661  LRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSL 720

Query: 721  DKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLC 780
            DKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLC
Sbjct: 721  DKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLC 780

Query: 781  IASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTG 840
            IASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTG
Sbjct: 781  IASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTG 840

Query: 841  AATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY 900
            AATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY
Sbjct: 841  AATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY 900

Query: 901  TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWL 960
            TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWL
Sbjct: 901  TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWL 960

Query: 961  GAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWD 1020
            GAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWD
Sbjct: 961  GAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWD 1020

Query: 1021 LSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQ 1080
            LSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQ
Sbjct: 1021 LSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQ 1080

Query: 1081 LAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVS 1140
            LAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVS
Sbjct: 1081 LAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVS 1140

Query: 1141 CNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAH 1200
            CNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAH
Sbjct: 1141 CNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAH 1200

Query: 1201 AQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISG 1260
            AQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISG
Sbjct: 1201 AQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISG 1260

Query: 1261 GEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307
            GEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE
Sbjct: 1261 GEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307


>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score = 2577 bits (6680), Expect = 0.0
 Identities = 1307/1321 (98%), Positives = 1307/1321 (98%), Gaps = 14/1321 (1%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240
            QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240

Query: 241  RSHTSLK--------------DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 286
            RSHTSLK              DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG
Sbjct: 241  RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 300

Query: 287  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346
            FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
Sbjct: 301  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 360

Query: 347  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 406
            KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL
Sbjct: 361  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 420

Query: 407  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 466
            LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA
Sbjct: 421  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 480

Query: 467  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 526
            EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
Sbjct: 481  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 540

Query: 527  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 586
            NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP
Sbjct: 541  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 600

Query: 587  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 646
            GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG
Sbjct: 601  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 660

Query: 647  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 706
            QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
Sbjct: 661  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 720

Query: 707  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 766
            TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN
Sbjct: 721  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 780

Query: 767  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 826
            ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG
Sbjct: 781  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 840

Query: 827  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 886
            GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
Sbjct: 841  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 900

Query: 887  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 946
            SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE
Sbjct: 901  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 960

Query: 947  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1006
            EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG
Sbjct: 961  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1020

Query: 1007 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1066
            TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
Sbjct: 1021 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1080

Query: 1067 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1126
            SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK
Sbjct: 1081 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1140

Query: 1127 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1186
            LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK
Sbjct: 1141 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1200

Query: 1187 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1246
            VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP
Sbjct: 1201 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1260

Query: 1247 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1306
            GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN
Sbjct: 1261 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1320

Query: 1307 E 1307
            E
Sbjct: 1321 E 1321


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score = 1389 bits (3595), Expect = 0.0
 Identities = 776/1363 (56%), Positives = 976/1363 (71%), Gaps = 94/1363 (6%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 240  PRSHTSLKDELSDVSQGG--SKATTPAST---ANSDVATIPTD--TPLKEENEGF----- 287
             +S +S +    ++S+ G  S A TP++T   +N+  +++P+   TPL E  +       
Sbjct: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300

Query: 288  -VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346
              K +    +   S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  +    
Sbjct: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360

Query: 347  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----MGREVENLILE 402
            +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG    MG+EV NL+LE
Sbjct: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420

Query: 403  NTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKA 462
            N+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELEEEL++ 
Sbjct: 421  NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRV 480

Query: 463  RAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQ 512
            ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQYKERLMELQ
Sbjct: 481  KSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ 540

Query: 513  EAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKYNAPTSH 570
            EAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN+ Y +PT+ 
Sbjct: 541  EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTT- 599

Query: 571  VTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
                 ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ HV+ +DGR+Q
Sbjct: 600  -AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRNDDGRLQ 656

Query: 631  AFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRD 688
            A GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLSG +  +
Sbjct: 657  ACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNE 716

Query: 689  GGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWIC 747
              +  G      +D    D EG  +  ++ +S +K      ++ KEL   +  SS VWI 
Sbjct: 717  DDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATSSRVWIL 770

Query: 748  TSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKA 807
            TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE   +S      
Sbjct: 771  TSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSD----- 825

Query: 808  SLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAE--NS 865
                   +      D +L GIT+VGC+        ++ S+ G +PV+DK     A   N 
Sbjct: 826  ------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEVATIANG 878

Query: 866  EVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSS 924
            +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP         S   Q  
Sbjct: 879  KVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----SSGPQPG 932

Query: 925  NDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIK 984
            +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA W+KCLHSIK
Sbjct: 933  SENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIK 991

Query: 985  LKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHD 1044
            LKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRCM VV+D
Sbjct: 992  LKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYD 1051

Query: 1045 KVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAH 1104
            +VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTLRLYHAH
Sbjct: 1052 RVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAH 1111

Query: 1105 TYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTET--- 1161
            T+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPLTET   
Sbjct: 1112 THQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVL 1171

Query: 1162 ----------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHR 1209
                      NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA AQLCFHGHR
Sbjct: 1172 HRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQLCFHGHR 1230

Query: 1210 DAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISGGEGYID 1266
            DAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV+SGGEGYID
Sbjct: 1231 DAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSGGEGYID 1287

Query: 1267 FRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307
            FR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1288 FRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1330


>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score = 1387 bits (3589), Expect = 0.0
 Identities = 776/1369 (56%), Positives = 976/1369 (71%), Gaps = 100/1369 (7%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 240  PRSHTSLKDELSDVSQGG--SKATTPAST---ANSDVATIPTD--TPLKEENEGF----- 287
             +S +S +    ++S+ G  S A TP++T   +N+  +++P+   TPL E  +       
Sbjct: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300

Query: 288  -VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346
              K +    +   S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  +    
Sbjct: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360

Query: 347  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----------MGREV 396
            +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG          MG+EV
Sbjct: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420

Query: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE 456
             NL+LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELE
Sbjct: 421  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480

Query: 457  EELRKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKE 506
            EEL++ ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQYKE
Sbjct: 481  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540

Query: 507  RLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKY 564
            RLMELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN+ Y
Sbjct: 541  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600

Query: 565  NAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK 624
             +PT+      ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ HV+ 
Sbjct: 601  KSPTT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRN 656

Query: 625  EDGRVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLS 682
            +DGR+QA GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLS
Sbjct: 657  DDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLS 716

Query: 683  GGKTRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741
            G +  +  +  G      +D    D EG  +  ++ +S +K      ++ KEL   +  S
Sbjct: 717  GWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATS 770

Query: 742  SLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSES 801
            S VWI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE   +S
Sbjct: 771  SRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDS 830

Query: 802  GQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEME 861
                         +      D +L GIT+VGC+        ++ S+ G +PV+DK     
Sbjct: 831  D-----------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEV 878

Query: 862  AE--NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLS 918
            A   N +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP         S
Sbjct: 879  ATIANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----S 932

Query: 919  PVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRK 978
               Q  +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA W+K
Sbjct: 933  SGPQPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKK 991

Query: 979  CLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRC 1038
            CLHSIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRC
Sbjct: 992  CLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRC 1051

Query: 1039 MTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTL 1098
            M VV+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTL
Sbjct: 1052 MAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTL 1111

Query: 1099 RLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPL 1158
            RLYHAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPL
Sbjct: 1112 RLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1171

Query: 1159 TET-------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQL 1203
            TET             NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA AQL
Sbjct: 1172 TETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQL 1230

Query: 1204 CFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISG 1260
            CFHGHRDAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV+SG
Sbjct: 1231 CFHGHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSG 1287

Query: 1261 GEGYIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307
            GEGYIDFR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1288 GEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1336


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  156 bits (394), Expect = 1e-37
 Identities = 158/616 (25%), Positives = 259/616 (42%), Gaps = 105/616 (17%)

Query: 734  LKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDY- 792
            L +  E S  VW+C S     +V ++      ++     VC++ +LCI +VPG +   + 
Sbjct: 1506 LNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHR 1565

Query: 793  ---------------PAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG-GITVVGCSAE 836
                           PAG +L      D+ +   +          S+ G G+ +     E
Sbjct: 1566 EPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGE 1625

Query: 837  GVTGAATSP----STNGASPVMDKPPEMEAENSEV-----DENVPTAEEATEATEGNAGS 887
            G       P    S + +SP      + +A  S +     +E  P+++EAT  T  +   
Sbjct: 1626 GDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEE 1685

Query: 888  AEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDS---DAYKDQISVLPNEQDLV 944
             E    +  +G +       P G   P D   + +SS+ S    + +D +SV P      
Sbjct: 1686 QEPGF-LPLSGSFGPG---GPCGTS-PMDGRALRRSSHGSFTRGSLEDLLSVDP------ 1734

Query: 945  REEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKD--SILSIVHVKGIVLVA 1002
              EA + S     +WLG ++GC++V+ S    R   +S+KL+   S+  I+++   V V+
Sbjct: 1735 --EAYQSS-----VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVS 1787

Query: 1003 LADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAM 1062
            LA+G L ++ R     WD  N+  + LG     I  M  V  ++WCG +N++ V+ P  +
Sbjct: 1788 LANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTL 1847

Query: 1063 KIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKML 1122
            ++E  F         V  +     GVWV+++  + + LYH  T++ L +VD+ P V +ML
Sbjct: 1848 QLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRML 1907

Query: 1123 GTGKLGF-----SFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIR 1177
                        + +RITAL+V    LWVGT  GV++++P +            PG+V  
Sbjct: 1908 AGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTS------------PGTVS- 1954

Query: 1178 VYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAV----------PGQVISPQS 1227
                            P   ++   L   GH   V+F  AV          P     P +
Sbjct: 1955 ---------------CPRAPLSPTGLG-QGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDT 1998

Query: 1228 SSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG-ESELLGEDLPLE 1286
                      +  P  + P    P   MLVISGG+GY DFR+   GG  SE +G D    
Sbjct: 1999 GPEKLPSLEHRDSPWHRGPAPARP--KMLVISGGDGYEDFRLSSGGGSSSETVGRD---- 2052

Query: 1287 PSVTKAERSHLIVWQV 1302
                    +HL++W+V
Sbjct: 2053 -----DSTNHLLLWRV 2063


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 948  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1005
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 884  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 943

Query: 1006 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 944  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 1002

Query: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1003 QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1061

Query: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1168
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1062 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1099


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 948  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1005
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 845  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 904

Query: 1006 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 905  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 963

Query: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 964  QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1022

Query: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1168
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1023 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1060


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 67/272 (24%), Positives = 124/272 (45%), Gaps = 47/272 (17%)

Query: 952  SSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKL-------KDSILSIVHVKGIVLVALA 1004
            +S +PT+ +G + G + ++ S    +K    ++L       K +++S+      +   L 
Sbjct: 960  ASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMSLACTSQSLYAGLV 1015

Query: 1005 DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064
            +G +A + R  DG WD     ++ LG     +R + ++ D +W     +++++  +   +
Sbjct: 1016 NGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAV 1073

Query: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124
            E   +AH  +   +  +A  G G+W++    STLRL+H  T +HLQD++I   V  ML  
Sbjct: 1074 EGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLP- 1132

Query: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS 1184
               G   + +T+L+V    L VGT  GV++++P+    +  G+P                
Sbjct: 1133 ---GHQRLSVTSLLVCHGLLMVGTSLGVLVALPVP---RLQGIP---------------- 1170

Query: 1185 DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFV 1216
             KVT              + +H H   VKF V
Sbjct: 1171 -KVT----------GRGMVSYHAHNSPVKFIV 1191


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 142/709 (20%), Positives = 288/709 (40%), Gaps = 85/709 (11%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVES-----L 124
            E + E+  ++++ ++   +  + +A RK  EEK +       QEK DLQ +V++     L
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLV----QEKNDLQLQVQAESENLL 900

Query: 125  ESQTR---------QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            +++ R         QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE
Sbjct: 901  DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD-IDDLE 959

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             T           E+   +   +   +   I  L      L    Q+  +   +E+ K  
Sbjct: 960  LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEEN----EGFVKVT 291
             L++ +S   L+ ++ D+     +          +   +  D  L +E+    E   +  
Sbjct: 1020 SLNKTKS--KLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077

Query: 292  DAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSST 351
            D   K +  ++ ++Q   E    + G    ++  E+QA IE     ++++++   + +  
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQ-TLGLQFQKKIKELQARIE-----ELEEEIEAERATRA 1131

Query: 352  PTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVENLILENTQL- 406
             T+  +   + R  E L E L  AG      ++      A+ L + R++E   L++  + 
Sbjct: 1132 KTEK-QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV 1190

Query: 407  --LETKNA------------LNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKN 452
              L  K+A            L  VK  L  +  E   E D L   +E+V ++K  LE+  
Sbjct: 1191 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250

Query: 453  RELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV-EMARVLMERNQYKERLMEL 511
            R LE++L +AR + E+ ++       S++ T + +  T   E++R L E+     +L   
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSL-----SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305

Query: 512  QEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHV 571
            ++A  +T+     +     + K ++++               ++ E     K     + +
Sbjct: 1306 KQA--FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK-----AEL 1358

Query: 572  TPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQA 631
              ++ K +S ++Q              + E     R E+  E  +++   +Q  + +V+A
Sbjct: 1359 QRALSKANSEVAQW-----------RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 632  FGWSLP--QKYKQVTNGQGENKMKNLPVPVYLRP-LDEKDTSMKLWCAVGVNLSGGKTRD 688
                    +K KQ   G+ E+ M ++     L   LD+K  +          L+  KT+ 
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV------LAEWKTKC 1461

Query: 689  GGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQ 737
              S        K+   L TE  K ++A + +LD+L + +K + K L+ +
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQL-ETVKRENKNLEQE 1509



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 132/668 (19%), Positives = 264/668 (39%), Gaps = 76/668 (11%)

Query: 36   ERLIGRYDEEVVKELMPLVVAVLENL-DSVFAQDQEHQVELELLRDDNEQLITQYEREKA 94
            E+L+    E+   +L   V A  ENL D+    DQ  + + +L     E +  + E E+ 
Sbjct: 876  EKLVTLVQEK--NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKE-VTERAEDEEE 932

Query: 95   LRKHAEEKFIEFEDSQEQEKKD---LQTRVESLESQTRQLELKAKNYADQISRLEEREAE 151
            +      K  + ED   + KKD   L+  +  +E +    E K KN  +++S L+E  A+
Sbjct: 933  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAK 992

Query: 152  LKKEYNALHQRHTEMIHNY------MEHLERTK------LHQLSGSDQLESTAHSRIRKE 199
            L +E  AL + H + + +       +  L +TK      +  L  S + E      + + 
Sbjct: 993  LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052

Query: 200  RPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQEL-SQPRSHTSLK---------- 247
            +    G   L     L L  D Q+  E    + +++ +L S+     +L           
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL 1112

Query: 248  ----DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHI 303
                +EL +  +             SD A    +   + E  G V  T      E++K  
Sbjct: 1113 QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQI----ELNKKR 1168

Query: 304  EVQVAQETRNVSTGSAENE------EKSEVQAIIESTPELD--------MDKDLSGYKGS 349
            E +  +  R++   + ++E       K    ++ E   ++D        ++K+ S +K  
Sbjct: 1169 EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK-- 1226

Query: 350  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLET 409
                  +E      + ES+ +  ++         D+ ++  G   E++  + E   L   
Sbjct: 1227 ------LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSE---LTTQ 1277

Query: 410  KNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA-KLKLEEKNRELEEELRKARAEAED 468
            K+ L     +L  +++E    K+ +  +L   KQA   + EE  R+LEEE  KA+     
Sbjct: 1278 KSRLQTEAGELSRQLEE----KESIVSQLSRSKQAFTQQTEELKRQLEEE-NKAKNALAH 1332

Query: 469  ARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQ--YKERLMELQEAVRWTEMIRASRE 526
            A Q ++ D D      + ++  + E+ R L + N    + R     +A++ TE +  +++
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392

Query: 527  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPV-NLKYNAPTSH-VTPSVKKRSSTLSQ 584
              A + +      +  +   +S   T ++ +  V +L  +   ++ +  ++ K+     +
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452

Query: 585  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED--GRVQAFGWSLPQKYKQ 642
            +  +     +    E EASL   R    E ++   A+ +  D    V+    +L Q+   
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512

Query: 643  VTNGQGEN 650
            +T    EN
Sbjct: 1513 LTEQIAEN 1520



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 118/596 (19%), Positives = 234/596 (39%), Gaps = 83/596 (13%)

Query: 65   FAQDQEHQVELE--LLRDDNE--QLITQYEREKALR----KHAEEKFIE-FEDSQEQ--- 112
            + ++QE + EL+  L + ++E  Q  T+YE +   R    + A++K  +  +DS+EQ   
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 113  -----------------EKKDLQTRVESLESQTRQLELKAKNY----ADQISRLEEREAE 151
                             E +DL   VE   S    L+ K +N+    A+  ++ EE +AE
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467

Query: 152  LK---KEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFP 208
            L+   KE  +L     ++ + Y E L           DQLE+        E+ I+  +  
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEAL-----------DQLETVKRENKNLEQEIA-DLTE 1515

Query: 209  LPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTAN 268
              A +G    + +K  +    E+   Q L+   +  +L+ E + + +   + T   S  +
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEKADIQ-LALEEAEAALEHEEAKILRIQLELTQVKSEID 1574

Query: 269  SDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQ 328
              +A    D  +++    + +  +     + +   EV+   E   +      +  + E+Q
Sbjct: 1575 RKIAE--KDEEIEQLKRNYQRTVET---MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629

Query: 329  AIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGAD 388
                +    +  K L   +G    T+   + A  R  E L E+L+         V+  A+
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL-RGQEDLKEQLAI--------VERRAN 1680

Query: 389  LLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKL 448
            LL    EVE L      L +T+ A  + + +L+   + +     +L  +  ++   K KL
Sbjct: 1681 LLQA--EVEEL---RATLEQTERARKLAEQELLDSNERV----QLLHTQNTSLIHTKKKL 1731

Query: 449  EEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERL 508
            E    +L+ E+  A  +A +A +KAK         A+  +  +   A +   +   ++ +
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791

Query: 509  MELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPT 568
             +LQ  +   E + A +      +K  + I +    L       T+  +     KY    
Sbjct: 1792 KDLQHRLDEAEQL-ALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG--LRKYERRV 1848

Query: 569  SHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK 624
              +T   ++    + +L          L ++ +  + S + Q  E   Q  AH+ K
Sbjct: 1849 KELTYQSEEDRKNVLRLQD--------LVDKLQVKVKSYKRQAEEADEQANAHLTK 1896


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 140/653 (21%), Positives = 262/653 (40%), Gaps = 85/653 (13%)

Query: 32   YREFERLIGRYDEEVVKELMPL--VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQY 89
            + E ER+     ++V K  + L  V  +L   DS  ++  +    LE    D ++L+ + 
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 90   EREKA-----LRKHAEEK--FIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQI 142
             R+K      L++  +EK  F E  + +E+ K +L+ ++ +L +Q   ++ K ++    +
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380

Query: 143  SRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH-QLSGSDQLESTAHSRI----- 196
               EE + +L+K+   L QRH E +  Y + LE+TK   Q    D L    H R      
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAY-DKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439

Query: 197  -RKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP------------RSH 243
             +K++     +            +  +       ++ K   L++             R +
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499

Query: 244  TSLKDELSDVSQ-----GGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSE 298
               + E+ D+       G S      S    +       T L+E  +      DA  + E
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559

Query: 299  ISKHIEVQVAQETRNVSTGSAENEEKSE--VQAIIESTPELDMDKD-----LSGYKGSST 351
            ++  ++   AQ  R++     ++EEK +  V+ + E   EL+ ++      ++  K    
Sbjct: 1560 VN--LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617

Query: 352  PTKGIE------NKAFDRNTESLFEELSSAGSGLIGDVDEGA----DLLGMGREVENLI- 400
              K +E      NK  D   + L  +L +     + ++D+      ++L   +E E  + 
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQL-RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676

Query: 401  ---LENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEE 457
                E  QL E   A    K     + DEL  E     G+     + K +LE +  +LEE
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736

Query: 458  ELRKARAEAE---DARQKAK---DDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMEL 511
            EL + +   E   D  +KA    D  ++D+   +R    + E AR  +ER Q KE  ++L
Sbjct: 1737 ELEEEQGNTELINDRLKKANLQIDQINTDL-NLERSHAQKNENARQQLER-QNKELKVKL 1794

Query: 512  QEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHV 571
            QE +  T   +      A++ K         ++L     N TK+ +        A    V
Sbjct: 1795 QE-MEGTVKSKYKASITALEAK--------IAQLEEQLDNETKERQ--------AACKQV 1837

Query: 572  TPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK 624
              + KK    L Q+  ++  A  +  +  +AS  +R +Q + Q  + +   Q+
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKAS--TRLKQLKRQLEEAEEEAQR 1888



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 103/516 (19%), Positives = 206/516 (39%), Gaps = 74/516 (14%)

Query: 15   GSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVE 74
            G    +S++++ L   I  E +  + + +EE+         A L  ++   AQ      +
Sbjct: 1055 GDSTDLSDQIAELQAQI-AELKMQLAKKEEELQ--------AALARVEEEAAQKNMALKK 1105

Query: 75   LELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELK 134
            +  L     +L    E E+A R  AE++  +  +  E  K +L+  ++S  +Q ++L  K
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSK 1164

Query: 135  AKNYADQISRLEEREAELKK-EYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAH 193
             +   + + +  E EA+  + +   + Q+H++ +    E LE+TK  + +    LE    
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN----LEKAKQ 1220

Query: 194  SRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSH-----TSLKD 248
            +   +   ++  +  L  G G      +K        Q KF E  + R+      T L+ 
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280

Query: 249  ELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVA 308
            EL +V+   S++ + +S    D + +  ++ L++  E    +    N+ ++S   +++  
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSAL--ESQLQDTQE----LLQEENRQKLSLSTKLKQV 1334

Query: 309  QETRNVSTGSAENEEKS----EVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN 364
            ++ +N      E EE++    E Q         DM K +    G     + ++ K     
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL---- 1390

Query: 365  TESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV 424
                                   DL G+ +  E  +    +L +TK  L    +DL+   
Sbjct: 1391 ---------------------QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV-- 1427

Query: 425  DELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTA 484
                        +L+  +Q+   LE+K ++ ++ L    AE +    K  ++ D     A
Sbjct: 1428 ------------DLDHQRQSACNLEKKQKKFDQLL----AEEKTISAKYAEERDRAEAEA 1471

Query: 485  QRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEM 520
            + K    + +AR L E  + K  L  L +  R TEM
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFR-TEM 1506



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 110/512 (21%), Positives = 210/512 (41%), Gaps = 90/512 (17%)

Query: 274  IPTDTPLKEENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 332
            + T+  LK+  E  + + D   K ++  K +E ++A+ T N++    E EEKS+  A ++
Sbjct: 967  VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT----EEEEKSKSLAKLK 1022

Query: 333  STPEL---DMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 389
            +  E    D+++ L                   R  E   +EL      L GD  + +D 
Sbjct: 1023 NKHEAMITDLEERL-------------------RREEKQRQELEKTRRKLEGDSTDLSDQ 1063

Query: 390  LGMGREVENLILE-NTQLLETKNALNIV----------KNDLIAKVDELTCEKDVLQGEL 438
            +    E++  I E   QL + +  L             KN  + K+ EL  +   LQ +L
Sbjct: 1064 IA---ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 439  EAVKQAKLKLEEKNRELEEELRKARAEAED------ARQ--KAKDDDDSDIPTAQRKRFT 490
            E+ + ++ K E++ R+L EEL   + E ED      A+Q  ++K + + +I     +   
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180

Query: 491  RVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQ-EKKRSSIWQFFSRLF--- 546
            +   A++   R ++ + + EL E +  T+ ++A+ E      E +R  +      L    
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240

Query: 547  SSSSNTTKKPE---PPVNLKYN---APTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET 600
              S +  KK E     + +K+N      + +   V K    L  + G  S++      ++
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS------DS 1294

Query: 601  EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQG---------ENK 651
            ++S  ++     E   Q    + +E+ R +    SL  K KQV + +          E  
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKL---SLSTKLKQVEDEKNSFREQLEEEEEA 1351

Query: 652  MKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSK 711
              NL   +        D   K+  +VG   +  + +            KD+ GL ++  +
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK--------RKLQKDLEGL-SQRHE 1402

Query: 712  QRSASQSSLDK----LDQELKEQQKELKNQEE 739
            ++ A+   L+K    L QEL +   +L +Q +
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 117/600 (19%), Positives = 245/600 (40%), Gaps = 105/600 (17%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKA-LRKHAEEKFIEFEDSQEQEKKDLQTRVESLES 126
            D+  ++++EL  D+   L++Q + + + L K       + +D+QE  +++ + ++ SL +
Sbjct: 1273 DKVTKLQVEL--DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL-SLST 1329

Query: 127  QTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM-------------------- 166
            + +Q+E +  ++ +Q+   EE +  L+K+   LH +  +M                    
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389

Query: 167  IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE- 225
            +   +E L +    +++  D+LE T  +R+++E             D L+  D Q+    
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKT-KTRLQQE-----------LDDLLVDLDHQRQSAC 1437

Query: 226  TPGSEQWKFQELSQPRSHTSLK---DELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 282
                +Q KF +L       S K   +     ++   K T   S A +    +     L+ 
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497

Query: 283  ENEGF-VKVTD-APNKSEISKHI------EVQVAQETRNVSTGSAENEEKSEVQAIIEST 334
             N+ F  ++ D   +K ++ K +      +  + Q+   + T   E E+  E+QA  ++ 
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED--ELQATEDA- 1554

Query: 335  PELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGR 394
             +L ++ +L   K             F+R+ +   E+       L+  V E      M  
Sbjct: 1555 -KLRLEVNLQAMKAQ-----------FERDLQGRDEQSEEKKKQLVRQVRE------MEA 1596

Query: 395  EVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRE 454
            E+E+   + +  +  +  L +   DL A +D     +D      EA+KQ + KL+ + ++
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD------EAIKQLR-KLQAQMKD 1649

Query: 455  LEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEA 514
               EL   RA  E+   +AK+++             + E+A     + Q ++   EL + 
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD- 1708

Query: 515  VRWTEMIRASRENP-AMQEKKR--SSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHV 571
                E+  +S +   A++EK+R  + I Q    L     N                T  +
Sbjct: 1709 ----EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN----------------TELI 1748

Query: 572  TPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQA 631
               +KK +  + Q+  D +     L         + R+Q   Q +++K  +Q+ +G V++
Sbjct: 1749 NDRLKKANLQIDQINTDLN-----LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 123/601 (20%), Positives = 240/601 (39%), Gaps = 57/601 (9%)

Query: 39   IGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKH 98
            + R +EE++ +   LV    + L +     +   ++ +L+ +   QL  Q + E  L   
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE-KLQLQEQLQAETELCAE 898

Query: 99   AEE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKE 155
            AEE   +    +   E+   DL+ RVE  E + + L+ + K     I  LEE   +L++E
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE---QLEEE 955

Query: 156  YNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR-------------IRKERPI 202
             +A  +   E +    + L++ +  Q+   DQ    A  +             + +E   
Sbjct: 956  ESARQKLQLEKVTTEAK-LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 203  SLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPR-----SHTSLKDELSDVSQGG 257
            S  +  L      +  D +   E    E+ + QEL + R       T L D+++++    
Sbjct: 1015 SKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071

Query: 258  SKATTPASTANSDV--ATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVS 315
            ++     +    ++  A    +    ++N    K+ +   +S+IS   E+Q   E+   S
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL--ESQIS---ELQEDLESERAS 1126

Query: 316  TGSAENEEK---SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEE 371
               AE +++    E++A+  E    LD        +        I  K  +   ++   +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186

Query: 372  LSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNA--LNIVKNDLIAKVDELTC 429
            +          V+E A+ L   + V+  + +  Q LE +     N VK  L  K D    
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246

Query: 430  EKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF 489
             K V + +L+ ++    + E    EL +++ K + E ++        D     +   K F
Sbjct: 1247 RKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS--SKLTKDF 1303

Query: 490  TRVE-----MARVLMERNQYKERLMELQEAVRWTEMIRAS-RENPAMQEKKRSSIWQFFS 543
            + +E        +L E N+ K   + L   ++  E  + S RE    +E+ + ++ +  +
Sbjct: 1304 SALESQLQDTQELLQEENRQK---LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360

Query: 544  RLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEAS 603
             L +  ++  KK E  V     A    V   ++K    LSQ   +K  A+D L E+T+  
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETA--EEVKRKLQKDLEGLSQRHEEKVAAYDKL-EKTKTR 1417

Query: 604  L 604
            L
Sbjct: 1418 L 1418



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 104/540 (19%), Positives = 202/540 (37%), Gaps = 95/540 (17%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
            +  D + A+++    +    RD  E    + E +      A E+ +E +   E+  K  +
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
            T +E L S    +             LE++  E+K +               +E LE   
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ---------------LEELE--- 1545

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS 238
                   D+L++T  +++R E         L A       D Q  G    SE+ K Q + 
Sbjct: 1546 -------DELQATEDAKLRLE-------VNLQAMKAQFERDLQ--GRDEQSEEKKKQLVR 1589

Query: 239  QPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPT--DTPLKEENEGFVKVTDAPNK 296
            Q R    ++ EL D  +  S A         D+  +    D+  K  +E   ++      
Sbjct: 1590 QVR---EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL------ 1640

Query: 297  SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGI 356
                + ++ Q+    R +    A  EE    QA         M+ ++   +      +  
Sbjct: 1641 ----RKLQAQMKDCMRELDDTRASREE-ILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695

Query: 357  ENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIV 416
            + +A     E   E  +S+G G +         L   R +E  I +  + LE +     +
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALA--------LEEKRRLEARIAQLEEELEEEQGNTEL 1747

Query: 417  KNDLIAK----VDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA-------- 464
             ND + K    +D++  + ++ +   +  + A+ +LE +N+EL+ +L++           
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807

Query: 465  -----EAEDARQKAKDDDDSDIPTAQRKRFTRVE--MARVLME-----RN--QYKERL-- 508
                 EA+ A+ + + D+++    A  K+  R E  +  VL++     RN  QYK++   
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867

Query: 509  ---------MELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPP 559
                      +L+EA    +   ASR     + +  +      +R  SS  N  ++ + P
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLP 1927



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 52/240 (21%), Positives = 104/240 (43%), Gaps = 25/240 (10%)

Query: 405  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 464
            +L   K  L  + +DL A+V+E       LQ E + ++Q   +LEE+  E E   +K + 
Sbjct: 905  RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964

Query: 465  E--AEDARQKAKDD-----DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRW 517
            E    +A+ K  ++     +D +   A+ K+     +A       + +E+   L +    
Sbjct: 965  EKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNK 1024

Query: 518  TE-MIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKK--------PEPPVNL-----K 563
             E MI    E    +EK+R  + +   +L   S++ + +         E  + L     +
Sbjct: 1025 HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084

Query: 564  YNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASR---REQKREQYRQVKA 620
              A  + V     +++  L ++   +S+  + L E+ E+  ASR    +QKR+   +++A
Sbjct: 1085 LQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERASRNKAEKQKRDLGEELEA 1143


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 105/519 (20%), Positives = 225/519 (43%), Gaps = 30/519 (5%)

Query: 22  ERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDD 81
           E+ SGL+   +     L+ R+ EEV KE   L+  V++  +S+ AQ  E Q E E  +++
Sbjct: 135 EQGSGLSMDQHSNIRDLL-RFKEEVTKERDQLLSEVVKLRESL-AQTTEQQQETERSKEE 192

Query: 82  NEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQ 141
            E  I+Q+++E   R++   +    ++  E+E K +Q  ++S +++ + L+   +   ++
Sbjct: 193 AEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEE 252

Query: 142 ISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERP 201
           + +LE++     KE   L++R  + +  +   +   KL Q +    L     S+  +++ 
Sbjct: 253 LQKLEQQ----LKEQKILNERAAKELEQF--QMRNAKLQQENEQHSLVCEQLSQENQQKA 306

Query: 202 ISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKAT 261
           + L           L  D  K  +       K       ++      E       G +  
Sbjct: 307 LELKAKEEEVHQMRL--DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLERE 364

Query: 262 TPASTANSDVATIPTDTPLKEE---NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGS 318
             AS   +++     D  L+E    N+  +K  +A  K        V++ ++ +    G 
Sbjct: 365 VEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL----VKLHEQAKRNLEGE 420

Query: 319 AENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTES-LFEELSSAGS 377
            +N  K E Q   +    L+ ++D    + S    K + N    +  E+ +F+       
Sbjct: 421 IQN-YKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479

Query: 378 GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
             I  + +  +L    R   NL  +N  L+E ++ +  +K  L   + ++    D L+ +
Sbjct: 480 SEI-KLKQQQNLYEAVRSDRNLYSKN--LVEAQDEITDMKRKLKIMIHQV----DELKED 532

Query: 438 LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDD-SDIPTAQRKRFTRVEMAR 496
           + A + A +KL  + + +E+E    +AE +  RQ+A +     +   A+ ++  R+ +A 
Sbjct: 533 ISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRI-IAE 591

Query: 497 VLMERNQYKERLMEL--QEAVRWTEMIRASRENPAMQEK 533
              ER + K+ L ++  +  +  ++++R + E   + EK
Sbjct: 592 ADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEK 630



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 31/165 (18%), Positives = 77/165 (46%), Gaps = 13/165 (7%)

Query: 389 LLGMGREVENLILENTQLLETKNALNIVKN----DLIAKVDELTCEKDVLQGELEAVKQA 444
           +L +  E+ NL    T+L+E  + L++ ++    DL+   +E+T E+D L  E+  ++++
Sbjct: 120 ILALKEEIVNL----TKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRES 175

Query: 445 KLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQY 504
             +  E+ +E E    +A       +Q+ +   +      ++K     E+ ++  + +  
Sbjct: 176 LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSR 235

Query: 505 KERLMELQEAVRWT-----EMIRASRENPAMQEKKRSSIWQFFSR 544
           +  +  LQ+ V+ +     ++ +  +E   + E+    + QF  R
Sbjct: 236 QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMR 280



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 54  VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRK--HAEEKFIEFEDSQE 111
           ++  +  L        E  VE ELL  + E+L  + +   A +    A E+   +  +  
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785

Query: 112 QEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMI 167
            +K+ L+     L S+    E+++K Y  ++ +L      LKK+Y  L Q+  E +
Sbjct: 786 DKKQQLKV----LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY--LAQKRKEQL 835


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 141/671 (21%), Positives = 267/671 (39%), Gaps = 108/671 (16%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 889

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q + +
Sbjct: 890  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPN 295
                 +    L+++L +      K      TA + +         K+  +  + + D  N
Sbjct: 945  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------KKLEDEILVMDDQNN 995

Query: 296  K-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTK 354
            K S+  K +E +++  T N+    AE EEK++    +++  E  M  +L           
Sbjct: 996  KLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMISELE---------- 1040

Query: 355  GIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENLILENTQLLETKNAL 413
             +  K  +++ + L E+L     G   D  E  ADL     E++  + +  + L+   A 
Sbjct: 1041 -VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098

Query: 414  N----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
                   KN+ + K+ EL      LQ +L++ + A+ K E++ R+L EEL   + E ED 
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158

Query: 470  --------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 521
                      +AK + +  +        TR   A+V   R ++ + + EL E +   +  
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 522  RASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSS 580
            +A+ + N    EK+ + +      L  +      K                    KK  +
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-------------------KKLEA 1259

Query: 581  TLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY 640
             + +L   +SK  D   E   A L  +  + + +   V   + + +G+       +    
Sbjct: 1260 QVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 641  KQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM---------------KLWCAVGVNLS 682
             Q+ + Q    E   + L V   LR L+E+  S+               +    + + LS
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 683  GGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLDK----LDQELKEQQ 731
              K +  D  S V     G   F K++  L T+  ++++A+   L+K    L QEL +  
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 732  KELKNQEELSS 742
             +L NQ +L S
Sbjct: 1434 VDLDNQRQLVS 1444



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 153/817 (18%), Positives = 319/817 (39%), Gaps = 151/817 (18%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL--------LTPDAQKGGETPGSE-- 230
                  +L    H +++ E     G+     G  +        L+   Q   E    E  
Sbjct: 1271 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 231  -----QWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 285
                   K ++L + R+  SL+D+L +  +         ST N  ++        K++ +
Sbjct: 1330 QKLNVSTKLRQLEEERN--SLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1381

Query: 286  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 338
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 339  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 391
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 392  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 444
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 445  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 476
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 477  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 536
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1669

Query: 537  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 596
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1670 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1713

Query: 597  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 645
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 646  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 704
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1774 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1828

Query: 705  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 138/679 (20%), Positives = 267/679 (39%), Gaps = 114/679 (16%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1285 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1336

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1337 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1441

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLK--DELSDV-SQGGSKATTPA 264
                    L  + +K       +Q KF +L     + S K  DE     ++   K T   
Sbjct: 1442 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 265  STANSDVATIP-------TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 317
            S A +    +        T+  LK E E  V   D   K+ + +  + + A ET+     
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEMK 1545

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
            +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+      
Sbjct: 1546 TQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNEEKRR 1592

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
             L   + E         E+E+   +       K  L     DL  + D        ++G 
Sbjct: 1593 QLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SAIKGR 1640

Query: 438  LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSDIPTA 484
             EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D+  A
Sbjct: 1641 EEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 485  QR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAMQEKK 534
            +R        K     E+A  L  RN  Q ++R +E + A    E+        AM ++ 
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 535  RSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKA 592
            R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G     
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGAVKSK 1811

Query: 593  FDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTNGQGE 649
            F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K     + +
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871

Query: 650  NKMKNLPVPVYLRPLDEKD 668
             +  N  V    R L+E +
Sbjct: 1872 AEKGNARVKQLKRQLEEAE 1890



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 134/693 (19%), Positives = 260/693 (37%), Gaps = 102/693 (14%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 953  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 219  DAQKGGETPGSEQWKFQELSQPRSHT--SLKDELSDVSQGGSKATTPASTANSDVATIPT 276
            +AQ             QE+ Q  +     L ++L    +  +       T   + A +  
Sbjct: 1191 EAQ------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 277  DTPL----KEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 332
            +  +    K+E E   K  +A  +   SK  + + A+   N      +NE +S    + E
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 333  STPE-LDMDKDLSGYKGSSTPTKGI--ENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 389
            +  + + + KD++        T+ +  E      N  +   +L    + L   +DE  + 
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358

Query: 390  -LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ----- 443
               + R +  L   N QL ++K  L     D  + V+ L   K   Q E+E + Q     
Sbjct: 1359 KQNLERHISTL---NIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411

Query: 444  --AKLKLEEKNRELEEEL------------------RKAR------AEAEDARQKAKDDD 477
              A  KLE+    L++EL                  +K R      AE ++   K  D+ 
Sbjct: 1412 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 478  DSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSS 537
            D     A+ K    + +AR L E  + KE      E  R  +M++A  E+    +     
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSKDDVGK 1525

Query: 538  IWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLS 597
                  +  S  +  T+  E    L+        T   K R     Q           L 
Sbjct: 1526 NVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA----------LK 1573

Query: 598  EETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
             + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 112/549 (20%), Positives = 217/549 (39%), Gaps = 103/549 (18%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1399 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1506

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1562

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQ 255
            +R E         + A  G    D Q   E    ++ + Q     R     + EL D  +
Sbjct: 1563 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-----RQLHEYETELEDERK 1610

Query: 256  GGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 313
              + A         D+  +    D+ +K   E   ++     + +  +  E++ A+ +R+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR-ELEDARASRD 1669

Query: 314  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 373
                +A+  EK   +A       + + +DL+  + +         K  D   E L EEL+
Sbjct: 1670 EIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RKQADLEKEELAEELA 1718

Query: 374  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV--------D 425
            S+ SG     DE        R +E  I +  + LE +       +D + K         +
Sbjct: 1719 SSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 426  ELTCEKDVLQG--------------------ELEAVKQAKLK-----LEEKNRELEE--- 457
            EL  E+   Q                     E+E   ++K K     LE K  +LEE   
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 458  -ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVR 516
             E R+ +A  +  +QK K   +  +     ++       +      + K+   +L+EA  
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891

Query: 517  WTEMIRASR 525
             ++ I A+R
Sbjct: 1892 ESQRINANR 1900



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 145/752 (19%), Positives = 291/752 (38%), Gaps = 121/752 (16%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 919  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 974

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 975  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 228  GSEQWKFQEL-----SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 282
               +    EL      + +S   L+     +    S      +   + +A +      KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 283  E---------NEGFVKVTDAPNK-SEISKHI-EVQVAQETRNVSTGSAENEEK---SEVQ 328
            E         ++   +  +A  K  E+  HI ++Q   ++   +   AE +++    E++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149

Query: 329  AI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGA 387
            A+  E    LD        +        +  KA D  T S   ++          V+E  
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209

Query: 388  DLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLK 447
            + L   +  +  + +N Q LE +NA                     L GEL  + QAK +
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVLGQAKQE 1249

Query: 448  LEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMAR- 496
            +E K ++LE +++          +ARAE  D   K +++ +S            +++A+ 
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 497  VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIWQFFSRL 545
            V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ +  S L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 546  FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDFLSEETE 601
                S++ KK      L+  A T       KKR       L+Q   +K+ A+D L E+T+
Sbjct: 1370 NIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTK 1422

Query: 602  ASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQGENKMKN 654
              L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + E + K 
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 655  LPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDT 707
                   R L+E        + + K+  A   +L   K   G +V               
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------------H 1528

Query: 708  EGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
            E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATED 1560


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 141/671 (21%), Positives = 267/671 (39%), Gaps = 108/671 (16%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 896

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q + +
Sbjct: 897  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPN 295
                 +    L+++L +      K      TA + +         K+  +  + + D  N
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------KKLEDEILVMDDQNN 1002

Query: 296  K-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTK 354
            K S+  K +E +++  T N+    AE EEK++    +++  E  M  +L           
Sbjct: 1003 KLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMISELE---------- 1047

Query: 355  GIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENLILENTQLLETKNAL 413
             +  K  +++ + L E+L     G   D  E  ADL     E++  + +  + L+   A 
Sbjct: 1048 -VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

Query: 414  N----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
                   KN+ + K+ EL      LQ +L++ + A+ K E++ R+L EEL   + E ED 
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 470  --------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 521
                      +AK + +  +        TR   A+V   R ++ + + EL E +   +  
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 522  RASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSS 580
            +A+ + N    EK+ + +      L  +      K                    KK  +
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-------------------KKLEA 1266

Query: 581  TLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY 640
             + +L   +SK  D   E   A L  +  + + +   V   + + +G+       +    
Sbjct: 1267 QVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 641  KQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM---------------KLWCAVGVNLS 682
             Q+ + Q    E   + L V   LR L+E+  S+               +    + + LS
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 683  GGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLDK----LDQELKEQQ 731
              K +  D  S V     G   F K++  L T+  ++++A+   L+K    L QEL +  
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 732  KELKNQEELSS 742
             +L NQ +L S
Sbjct: 1441 VDLDNQRQLVS 1451



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 153/817 (18%), Positives = 319/817 (39%), Gaps = 151/817 (18%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL--------LTPDAQKGGETPGSE-- 230
                  +L    H +++ E     G+     G  +        L+   Q   E    E  
Sbjct: 1278 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 231  -----QWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 285
                   K ++L + R+  SL+D+L +  +         ST N  ++        K++ +
Sbjct: 1337 QKLNVSTKLRQLEEERN--SLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1388

Query: 286  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 338
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 339  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 391
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 392  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 444
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 445  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 476
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 477  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 536
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1676

Query: 537  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 596
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1677 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1720

Query: 597  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 645
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 646  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 704
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1781 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1835

Query: 705  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 138/679 (20%), Positives = 267/679 (39%), Gaps = 114/679 (16%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1292 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1343

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1344 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1448

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLK--DELSDV-SQGGSKATTPA 264
                    L  + +K       +Q KF +L     + S K  DE     ++   K T   
Sbjct: 1449 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 265  STANSDVATIP-------TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 317
            S A +    +        T+  LK E E  V   D   K+ + +  + + A ET+     
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEMK 1552

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
            +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+      
Sbjct: 1553 TQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNEEKRR 1599

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
             L   + E         E+E+   +       K  L     DL  + D        ++G 
Sbjct: 1600 QLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SAIKGR 1647

Query: 438  LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSDIPTA 484
             EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D+  A
Sbjct: 1648 EEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 485  QR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAMQEKK 534
            +R        K     E+A  L  RN  Q ++R +E + A    E+        AM ++ 
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 535  RSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKA 592
            R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G     
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGAVKSK 1818

Query: 593  FDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTNGQGE 649
            F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K     + +
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878

Query: 650  NKMKNLPVPVYLRPLDEKD 668
             +  N  V    R L+E +
Sbjct: 1879 AEKGNARVKQLKRQLEEAE 1897



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 134/693 (19%), Positives = 260/693 (37%), Gaps = 102/693 (14%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 960  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 219  DAQKGGETPGSEQWKFQELSQPRSHT--SLKDELSDVSQGGSKATTPASTANSDVATIPT 276
            +AQ             QE+ Q  +     L ++L    +  +       T   + A +  
Sbjct: 1198 EAQ------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 277  DTPL----KEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 332
            +  +    K+E E   K  +A  +   SK  + + A+   N      +NE +S    + E
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 333  STPE-LDMDKDLSGYKGSSTPTKGI--ENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 389
            +  + + + KD++        T+ +  E      N  +   +L    + L   +DE  + 
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 390  -LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ----- 443
               + R +  L   N QL ++K  L     D  + V+ L   K   Q E+E + Q     
Sbjct: 1366 KQNLERHISTL---NIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418

Query: 444  --AKLKLEEKNRELEEEL------------------RKAR------AEAEDARQKAKDDD 477
              A  KLE+    L++EL                  +K R      AE ++   K  D+ 
Sbjct: 1419 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 478  DSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSS 537
            D     A+ K    + +AR L E  + KE      E  R  +M++A  E+    +     
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSKDDVGK 1532

Query: 538  IWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLS 597
                  +  S  +  T+  E    L+        T   K R     Q           L 
Sbjct: 1533 NVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA----------LK 1580

Query: 598  EETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
             + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 112/549 (20%), Positives = 217/549 (39%), Gaps = 103/549 (18%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1406 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1513

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1569

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQ 255
            +R E         + A  G    D Q   E    ++ + Q     R     + EL D  +
Sbjct: 1570 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-----RQLHEYETELEDERK 1617

Query: 256  GGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 313
              + A         D+  +    D+ +K   E   ++     + +  +  E++ A+ +R+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR-ELEDARASRD 1676

Query: 314  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 373
                +A+  EK   +A       + + +DL+  + +         K  D   E L EEL+
Sbjct: 1677 EIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RKQADLEKEELAEELA 1725

Query: 374  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV--------D 425
            S+ SG     DE        R +E  I +  + LE +       +D + K         +
Sbjct: 1726 SSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 426  ELTCEKDVLQG--------------------ELEAVKQAKLK-----LEEKNRELEE--- 457
            EL  E+   Q                     E+E   ++K K     LE K  +LEE   
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 458  -ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVR 516
             E R+ +A  +  +QK K   +  +     ++       +      + K+   +L+EA  
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898

Query: 517  WTEMIRASR 525
             ++ I A+R
Sbjct: 1899 ESQRINANR 1907



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 145/752 (19%), Positives = 291/752 (38%), Gaps = 121/752 (16%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 926  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 981

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 982  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 228  GSEQWKFQEL-----SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 282
               +    EL      + +S   L+     +    S      +   + +A +      KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 283  E---------NEGFVKVTDAPNK-SEISKHI-EVQVAQETRNVSTGSAENEEK---SEVQ 328
            E         ++   +  +A  K  E+  HI ++Q   ++   +   AE +++    E++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156

Query: 329  AI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGA 387
            A+  E    LD        +        +  KA D  T S   ++          V+E  
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216

Query: 388  DLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLK 447
            + L   +  +  + +N Q LE +NA                     L GEL  + QAK +
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVLGQAKQE 1256

Query: 448  LEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMAR- 496
            +E K ++LE +++          +ARAE  D   K +++ +S            +++A+ 
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 497  VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIWQFFSRL 545
            V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ +  S L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 546  FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDFLSEETE 601
                S++ KK      L+  A T       KKR       L+Q   +K+ A+D L E+T+
Sbjct: 1377 NIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTK 1429

Query: 602  ASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQGENKMKN 654
              L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + E + K 
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 655  LPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDT 707
                   R L+E        + + K+  A   +L   K   G +V               
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------------H 1535

Query: 708  EGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
            E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATED 1567


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 141/671 (21%), Positives = 267/671 (39%), Gaps = 108/671 (16%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 896

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q + +
Sbjct: 897  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPN 295
                 +    L+++L +      K      TA + +         K+  +  + + D  N
Sbjct: 952  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------KKLEDEILVMDDQNN 1002

Query: 296  K-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTK 354
            K S+  K +E +++  T N+    AE EEK++    +++  E  M  +L           
Sbjct: 1003 KLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMISELE---------- 1047

Query: 355  GIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENLILENTQLLETKNAL 413
             +  K  +++ + L E+L     G   D  E  ADL     E++  + +  + L+   A 
Sbjct: 1048 -VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

Query: 414  N----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
                   KN+ + K+ EL      LQ +L++ + A+ K E++ R+L EEL   + E ED 
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 470  --------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 521
                      +AK + +  +        TR   A+V   R ++ + + EL E +   +  
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 522  RASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSS 580
            +A+ + N    EK+ + +      L  +      K                    KK  +
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-------------------KKLEA 1266

Query: 581  TLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY 640
             + +L   +SK  D   E   A L  +  + + +   V   + + +G+       +    
Sbjct: 1267 QVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 641  KQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM---------------KLWCAVGVNLS 682
             Q+ + Q    E   + L V   LR L+E+  S+               +    + + LS
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 683  GGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLDK----LDQELKEQQ 731
              K +  D  S V     G   F K++  L T+  ++++A+   L+K    L QEL +  
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 732  KELKNQEELSS 742
             +L NQ +L S
Sbjct: 1441 VDLDNQRQLVS 1451



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 153/817 (18%), Positives = 319/817 (39%), Gaps = 151/817 (18%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL--------LTPDAQKGGETPGSE-- 230
                  +L    H +++ E     G+     G  +        L+   Q   E    E  
Sbjct: 1278 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 231  -----QWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 285
                   K ++L + R+  SL+D+L +  +         ST N  ++        K++ +
Sbjct: 1337 QKLNVSTKLRQLEEERN--SLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1388

Query: 286  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 338
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 339  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 391
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 392  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 444
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 445  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 476
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 477  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 536
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1676

Query: 537  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 596
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1677 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1720

Query: 597  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 645
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 646  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 704
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1781 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1835

Query: 705  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 138/679 (20%), Positives = 267/679 (39%), Gaps = 114/679 (16%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1292 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1343

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1344 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1448

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLK--DELSDV-SQGGSKATTPA 264
                    L  + +K       +Q KF +L     + S K  DE     ++   K T   
Sbjct: 1449 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 265  STANSDVATIP-------TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 317
            S A +    +        T+  LK E E  V   D   K+ + +  + + A ET+     
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEMK 1552

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
            +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+      
Sbjct: 1553 TQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNEEKRR 1599

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
             L   + E         E+E+   +       K  L     DL  + D        ++G 
Sbjct: 1600 QLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SAIKGR 1647

Query: 438  LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSDIPTA 484
             EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D+  A
Sbjct: 1648 EEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 485  QR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAMQEKK 534
            +R        K     E+A  L  RN  Q ++R +E + A    E+        AM ++ 
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 535  RSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKA 592
            R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G     
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGAVKSK 1818

Query: 593  FDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTNGQGE 649
            F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K     + +
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878

Query: 650  NKMKNLPVPVYLRPLDEKD 668
             +  N  V    R L+E +
Sbjct: 1879 AEKGNARVKQLKRQLEEAE 1897



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 134/693 (19%), Positives = 260/693 (37%), Gaps = 102/693 (14%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 960  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 219  DAQKGGETPGSEQWKFQELSQPRSHT--SLKDELSDVSQGGSKATTPASTANSDVATIPT 276
            +AQ             QE+ Q  +     L ++L    +  +       T   + A +  
Sbjct: 1198 EAQ------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 277  DTPL----KEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 332
            +  +    K+E E   K  +A  +   SK  + + A+   N      +NE +S    + E
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 333  STPE-LDMDKDLSGYKGSSTPTKGI--ENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 389
            +  + + + KD++        T+ +  E      N  +   +L    + L   +DE  + 
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 390  -LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ----- 443
               + R +  L   N QL ++K  L     D  + V+ L   K   Q E+E + Q     
Sbjct: 1366 KQNLERHISTL---NIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418

Query: 444  --AKLKLEEKNRELEEEL------------------RKAR------AEAEDARQKAKDDD 477
              A  KLE+    L++EL                  +K R      AE ++   K  D+ 
Sbjct: 1419 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 478  DSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSS 537
            D     A+ K    + +AR L E  + KE      E  R  +M++A  E+    +     
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSKDDVGK 1532

Query: 538  IWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLS 597
                  +  S  +  T+  E    L+        T   K R     Q           L 
Sbjct: 1533 NVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA----------LK 1580

Query: 598  EETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
             + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 115/582 (19%), Positives = 228/582 (39%), Gaps = 103/582 (17%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1406 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1513

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1569

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQ 255
            +R E         + A  G    D Q   E    ++ + Q     R     + EL D  +
Sbjct: 1570 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-----RQLHEYETELEDERK 1617

Query: 256  GGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 313
              + A         D+  +    D+ +K   E   ++     + +  +  E++ A+ +R+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR-ELEDARASRD 1676

Query: 314  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 373
                +A+  EK   +A       + + +DL+  + +         K  D   E L EEL+
Sbjct: 1677 EIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RKQADLEKEELAEELA 1725

Query: 374  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV--------D 425
            S+ SG     DE        R +E  I +  + LE +       +D + K         +
Sbjct: 1726 SSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 426  ELTCEKDVLQG--------------------ELEAVKQAKLK-----LEEKNRELEE--- 457
            EL  E+   Q                     E+E   ++K K     LE K  +LEE   
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 458  -ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVR 516
             E R+ +A  +  +QK K   +  +     ++       +      + K+   +L+EA  
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898

Query: 517  WTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 558
             ++ I A+R     +  + +   +   R  ++  +  + P P
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 145/752 (19%), Positives = 291/752 (38%), Gaps = 121/752 (16%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 926  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 981

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 982  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 228  GSEQWKFQEL-----SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 282
               +    EL      + +S   L+     +    S      +   + +A +      KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 283  E---------NEGFVKVTDAPNK-SEISKHI-EVQVAQETRNVSTGSAENEEK---SEVQ 328
            E         ++   +  +A  K  E+  HI ++Q   ++   +   AE +++    E++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156

Query: 329  AI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGA 387
            A+  E    LD        +        +  KA D  T S   ++          V+E  
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216

Query: 388  DLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLK 447
            + L   +  +  + +N Q LE +NA                     L GEL  + QAK +
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVLGQAKQE 1256

Query: 448  LEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMAR- 496
            +E K ++LE +++          +ARAE  D   K +++ +S            +++A+ 
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 497  VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIWQFFSRL 545
            V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ +  S L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 546  FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDFLSEETE 601
                S++ KK      L+  A T       KKR       L+Q   +K+ A+D L E+T+
Sbjct: 1377 NIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTK 1429

Query: 602  ASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQGENKMKN 654
              L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + E + K 
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 655  LPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDT 707
                   R L+E        + + K+  A   +L   K   G +V               
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------------H 1535

Query: 708  EGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
            E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATED 1567


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 141/671 (21%), Positives = 267/671 (39%), Gaps = 108/671 (16%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 889

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q + +
Sbjct: 890  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPN 295
                 +    L+++L +      K      TA + +         K+  +  + + D  N
Sbjct: 945  RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------KKLEDEILVMDDQNN 995

Query: 296  K-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTK 354
            K S+  K +E +++  T N+    AE EEK++    +++  E  M  +L           
Sbjct: 996  KLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMISELE---------- 1040

Query: 355  GIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENLILENTQLLETKNAL 413
             +  K  +++ + L E+L     G   D  E  ADL     E++  + +  + L+   A 
Sbjct: 1041 -VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098

Query: 414  N----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
                   KN+ + K+ EL      LQ +L++ + A+ K E++ R+L EEL   + E ED 
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158

Query: 470  --------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 521
                      +AK + +  +        TR   A+V   R ++ + + EL E +   +  
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 522  RASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSS 580
            +A+ + N    EK+ + +      L  +      K                    KK  +
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK-------------------KKLEA 1259

Query: 581  TLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY 640
             + +L   +SK  D   E   A L  +  + + +   V   + + +G+       +    
Sbjct: 1260 QVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 641  KQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM---------------KLWCAVGVNLS 682
             Q+ + Q    E   + L V   LR L+E+  S+               +    + + LS
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 683  GGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLDK----LDQELKEQQ 731
              K +  D  S V     G   F K++  L T+  ++++A+   L+K    L QEL +  
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 732  KELKNQEELSS 742
             +L NQ +L S
Sbjct: 1434 VDLDNQRQLVS 1444



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 153/817 (18%), Positives = 319/817 (39%), Gaps = 151/817 (18%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL--------LTPDAQKGGETPGSE-- 230
                  +L    H +++ E     G+     G  +        L+   Q   E    E  
Sbjct: 1271 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 231  -----QWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 285
                   K ++L + R+  SL+D+L +  +         ST N  ++        K++ +
Sbjct: 1330 QKLNVSTKLRQLEEERN--SLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1381

Query: 286  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 338
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 339  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 391
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 392  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 444
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 445  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 476
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 477  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 536
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1669

Query: 537  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 596
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1670 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1713

Query: 597  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 645
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 646  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 704
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1774 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1828

Query: 705  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 138/679 (20%), Positives = 267/679 (39%), Gaps = 114/679 (16%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1285 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1336

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1337 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1441

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLK--DELSDV-SQGGSKATTPA 264
                    L  + +K       +Q KF +L     + S K  DE     ++   K T   
Sbjct: 1442 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 265  STANSDVATIP-------TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 317
            S A +    +        T+  LK E E  V   D   K+ + +  + + A ET+     
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEMK 1545

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
            +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+      
Sbjct: 1546 TQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNEEKRR 1592

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
             L   + E         E+E+   +       K  L     DL  + D        ++G 
Sbjct: 1593 QLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SAIKGR 1640

Query: 438  LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSDIPTA 484
             EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D+  A
Sbjct: 1641 EEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 485  QR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAMQEKK 534
            +R        K     E+A  L  RN  Q ++R +E + A    E+        AM ++ 
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 535  RSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKA 592
            R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G     
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGAVKSK 1811

Query: 593  FDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTNGQGE 649
            F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K     + +
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871

Query: 650  NKMKNLPVPVYLRPLDEKD 668
             +  N  V    R L+E +
Sbjct: 1872 AEKGNARVKQLKRQLEEAE 1890



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 134/693 (19%), Positives = 260/693 (37%), Gaps = 102/693 (14%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 953  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 219  DAQKGGETPGSEQWKFQELSQPRSHT--SLKDELSDVSQGGSKATTPASTANSDVATIPT 276
            +AQ             QE+ Q  +     L ++L    +  +       T   + A +  
Sbjct: 1191 EAQ------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 277  DTPL----KEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 332
            +  +    K+E E   K  +A  +   SK  + + A+   N      +NE +S    + E
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 333  STPE-LDMDKDLSGYKGSSTPTKGI--ENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 389
            +  + + + KD++        T+ +  E      N  +   +L    + L   +DE  + 
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358

Query: 390  -LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ----- 443
               + R +  L   N QL ++K  L     D  + V+ L   K   Q E+E + Q     
Sbjct: 1359 KQNLERHISTL---NIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411

Query: 444  --AKLKLEEKNRELEEEL------------------RKAR------AEAEDARQKAKDDD 477
              A  KLE+    L++EL                  +K R      AE ++   K  D+ 
Sbjct: 1412 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 478  DSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSS 537
            D     A+ K    + +AR L E  + KE      E  R  +M++A  E+    +     
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSKDDVGK 1525

Query: 538  IWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLS 597
                  +  S  +  T+  E    L+        T   K R     Q           L 
Sbjct: 1526 NVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA----------LK 1573

Query: 598  EETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
             + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 115/582 (19%), Positives = 228/582 (39%), Gaps = 103/582 (17%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1399 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1506

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1562

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQ 255
            +R E         + A  G    D Q   E    ++ + Q     R     + EL D  +
Sbjct: 1563 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-----RQLHEYETELEDERK 1610

Query: 256  GGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 313
              + A         D+  +    D+ +K   E   ++     + +  +  E++ A+ +R+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR-ELEDARASRD 1669

Query: 314  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 373
                +A+  EK   +A       + + +DL+  + +         K  D   E L EEL+
Sbjct: 1670 EIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RKQADLEKEELAEELA 1718

Query: 374  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV--------D 425
            S+ SG     DE        R +E  I +  + LE +       +D + K         +
Sbjct: 1719 SSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 426  ELTCEKDVLQG--------------------ELEAVKQAKLK-----LEEKNRELEE--- 457
            EL  E+   Q                     E+E   ++K K     LE K  +LEE   
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 458  -ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVR 516
             E R+ +A  +  +QK K   +  +     ++       +      + K+   +L+EA  
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891

Query: 517  WTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 558
             ++ I A+R     +  + +   +   R  ++  +  + P P
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 145/752 (19%), Positives = 291/752 (38%), Gaps = 121/752 (16%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 919  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 974

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 975  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 228  GSEQWKFQEL-----SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 282
               +    EL      + +S   L+     +    S      +   + +A +      KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 283  E---------NEGFVKVTDAPNK-SEISKHI-EVQVAQETRNVSTGSAENEEK---SEVQ 328
            E         ++   +  +A  K  E+  HI ++Q   ++   +   AE +++    E++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149

Query: 329  AI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGA 387
            A+  E    LD        +        +  KA D  T S   ++          V+E  
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209

Query: 388  DLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLK 447
            + L   +  +  + +N Q LE +NA                     L GEL  + QAK +
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVLGQAKQE 1249

Query: 448  LEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMAR- 496
            +E K ++LE +++          +ARAE  D   K +++ +S            +++A+ 
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 497  VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIWQFFSRL 545
            V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ +  S L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 546  FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDFLSEETE 601
                S++ KK      L+  A T       KKR       L+Q   +K+ A+D L E+T+
Sbjct: 1370 NIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTK 1422

Query: 602  ASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQGENKMKN 654
              L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + E + K 
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 655  LPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDT 707
                   R L+E        + + K+  A   +L   K   G +V               
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------------H 1528

Query: 708  EGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
            E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATED 1560


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/727 (20%), Positives = 288/727 (39%), Gaps = 116/727 (15%)

Query: 48   KELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLI--------------TQYEREK 93
            KEL   +V++L+  + +  Q Q  Q  L    +  +QLI               + E E+
Sbjct: 873  KELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEE 932

Query: 94   ALRKHAEEKFIEFEDSQEQEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREA 150
             +      K  + ED   + KK   DL+  +  +E +    E K KN  ++++ L+E  A
Sbjct: 933  EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992

Query: 151  ELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGS----DQLESTAHSRIRKERPISLGI 206
            +L KE  AL + H + + +    +E  K++ LS S    +Q        + +E+ + + +
Sbjct: 993  KLTKEKKALQEAHQQALDDL--QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050

Query: 207  FPLP---AGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTP 263
                    GD  LT ++    E   +++ + +E         LK +  D++Q  SK    
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLE---NDKLQLEE--------KLKKKEFDINQQNSK---- 1095

Query: 264  ASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEE 323
                +  V  +     LKE            N++ I +  E   A+ T         ++ 
Sbjct: 1096 --IEDEQVLALQLQKKLKE------------NQARIEELEEELEAERTARAKVEKLRSDL 1141

Query: 324  KSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDV 383
              E++ I E   E           G +T  +   NK  +   + +  +L  A       +
Sbjct: 1142 SRELEEISERLEE----------AGGATSVQIEMNKKREAEFQKMRRDLEEA------TL 1185

Query: 384  DEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ 443
               A    + ++  + + E   L E  + L  VK  L  +  E   E D +   +E + +
Sbjct: 1186 QHEATAAALRKKHADSVAE---LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242

Query: 444  AKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF--TRVEMARVLMER 501
            AK  LE+ +R LE++  + R + E+A++   D       T QR +      E+AR L E+
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDF------TTQRAKLQTENGELARQLEEK 1296

Query: 502  NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 561
                 +L   +  + +T+ +   +     + K ++++        + +  + +     + 
Sbjct: 1297 EALISQL--TRGKLSYTQQMEDLKRQLEEEGKAKNAL--------AHALQSARHDCDLLR 1346

Query: 562  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 621
             +Y   T       +  S   S++   ++K       ET+A    R E+  E  +++   
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTK------YETDA--IQRTEELEEAKKKLAQR 1398

Query: 622  VQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPV-----YLRPLDEKDTSMKLWCA 676
            +Q  +  V+A         K  T  + +N++++L V V         LD+K  +     A
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEK--TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1456

Query: 677  VGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKN 736
                    K  +  S + +S   K+   L TE  K ++A + SL+ L +  K + K L  
Sbjct: 1457 EWKQ----KYEESQSELESS--QKEARSLSTELFKLKNAYEESLEHL-ETFKRENKNL-- 1507

Query: 737  QEELSSL 743
            QEE+S L
Sbjct: 1508 QEEISDL 1514



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 158/778 (20%), Positives = 285/778 (36%), Gaps = 174/778 (22%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKAL--RKHAE---------EKFIEFEDSQEQEKKD 116
            +++ + E + +R D E+   Q+E   A   +KHA+         +     +   E+EK +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225

Query: 117  LQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLER 176
             +  ++ + S   Q+ +KAK   +++SR  E +A    EY    +     ++++    +R
Sbjct: 1226 FKLELDDVTSNMEQI-IKAKANLEKVSRTLEDQAN---EYRVKLEEAQRSLNDFTT--QR 1279

Query: 177  TKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP---DAQKGGETPGSEQWK 233
             KL   +G       A     KE  IS     L  G    T    D ++  E  G  +  
Sbjct: 1280 AKLQTENGE-----LARQLEEKEALIS----QLTRGKLSYTQQMEDLKRQLEEEGKAKNA 1330

Query: 234  FQELSQPRSHTS--LKDELSDVSQGGSKATTPASTANSDVATIPTDTP------------ 279
                 Q   H    L+++  + ++  ++     S ANS+VA   T               
Sbjct: 1331 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1390

Query: 280  --------LKEENEGFVKVTDAPNKSEISKHI------EVQVAQETRNVSTGSAENEEKS 325
                    L++  E    V    +  E +KH       ++ V  E  N +  + + ++++
Sbjct: 1391 AKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1450

Query: 326  -------------EVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN-KAFDRNTESLFEE 371
                         E Q+ +ES+ +         +K  +   + +E+ + F R  ++L EE
Sbjct: 1451 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE 1510

Query: 372  LSSAGSGLIGDVDEGADLLGMGR---EVENLILENT-------------QLLETKNALNI 415
            +S     L G+  +    L   R   EVE L L++              ++L  +   N 
Sbjct: 1511 ISDLTEQL-GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569

Query: 416  VKNDLIAKVDELTCEK-----------DVLQGELEA-------VKQAKLKLEEKNRELEE 457
            +K ++  K+ E   E            D LQ  L+A       V + K K+E    E+E 
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEI 1629

Query: 458  ELRKARAEAEDARQKAKD------DDDSDIPTAQRKRFTRVEMARVLMERNQ-YKERLME 510
            +L  A   A +A+++ K       D    +  A R      E   ++  RN   +  L E
Sbjct: 1630 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1689

Query: 511  LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSH 570
            L+  V  TE  R   E   ++  +R                        V L ++  TS 
Sbjct: 1690 LRAVVEQTERSRKLAEQELIETSER------------------------VQLLHSQNTSL 1725

Query: 571  VTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
            +    KK  S L+QL           SE  EA    R  +++ +     A +  E+    
Sbjct: 1726 INQK-KKMESDLTQLQ----------SEVEEAVQECRNAEEKAKKAITDAAMMAEE---- 1770

Query: 631  AFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGG 690
                    K +Q T+   E   KN+   +       KD   +L  A  + L GGK +   
Sbjct: 1771 -------LKKEQDTSAHLERMKKNMEQTI-------KDLQHRLDEAEQIALKGGKKQ--- 1813

Query: 691  SVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKE----QQKELKNQEELSSLV 744
             +       +++ G      K+ + S   + K ++ +KE     +++ KN   L  LV
Sbjct: 1814 -LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLV 1870



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 30/161 (18%), Positives = 74/161 (45%), Gaps = 16/161 (9%)

Query: 394  REVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNR 453
            +E+  +  E  ++ ET       + +L  K+  L  EK+ LQ +++A +      EE+  
Sbjct: 849  KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCD 908

Query: 454  ELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVE--------------MARVLM 499
            +L +   +  A+ ++  ++ +D+++ +     +KR    E              +A+V  
Sbjct: 909  QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 968

Query: 500  ERNQYKERLMELQEAVRWTEMI--RASRENPAMQEKKRSSI 538
            E++  + ++  L E +   + I  + ++E  A+QE  + ++
Sbjct: 969  EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1009


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 124/634 (19%), Positives = 250/634 (39%), Gaps = 78/634 (12%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYER----EKALRKHA 99
            E++VKE+  L  + +        + +E Q E E+L    E +  + ER     +A+R+  
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643

Query: 100  EE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEY 156
            +E   K    E ++++ +K LQ   + +E    ++   AK+   +I  LEE    L+ E 
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703

Query: 157  NALHQRHTEMIHNYM-------EHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPL 209
            +       E +   +       E LER K+   + S + +S    +      +       
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ------ 1757

Query: 210  PAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANS 269
                     D +   E   S+Q   +        T   D  ++V++ G++ + P  T   
Sbjct: 1758 ---------DLKHQIEGNVSKQANLEA-------TEKHDNQTNVTEEGTQ-SIPGETEEQ 1800

Query: 270  DVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEV-QVAQETRNVSTGSAENEEKSEVQ 328
            D  ++ T  P   E+    K  +     + S H E+    Q+   +    A  EE+ +  
Sbjct: 1801 DSLSMST-RPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKN 1859

Query: 329  AIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEG 386
                 T E + +  LS         K ++ +    N   + + EELS   + L    +E 
Sbjct: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV-TKLKETAEEE 1918

Query: 387  ADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKL 446
             D      ++E  ++   QL E   ++     D    V +   + ++L+ E++ +K+   
Sbjct: 1919 KD------DLEERLM--NQLAELNGSIGNYCQD----VTDAQIKNELLESEMKNLKKCVS 1966

Query: 447  KLEEKNREL-------EEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLM 499
            +LEE+ ++L       E E+RK   E     QK   +        +  +  + E+ ++  
Sbjct: 1967 ELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQK 2026

Query: 500  ERNQYKERLMELQEAVRWTEMIRA--------SREN--PAMQEKKRSSIWQFFSRLFSSS 549
            +  +Y+E++  L+  V+  E ++         ++EN   A++ +K++       ++    
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086

Query: 550  SNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRRE 609
            + +        NLK          SVK   S + Q   D  +  +  +EE         +
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVK---SQMKQKDEDLERRLE-QAEEKHLKEKKNMQ 2142

Query: 610  QKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQV 643
            +K +  R+ K H+++  G +Q    +L +K K+V
Sbjct: 2143 EKLDALRREKVHLEETIGEIQV---TLNKKDKEV 2173



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 105/486 (21%), Positives = 191/486 (39%), Gaps = 74/486 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
            ENLDS   Q       +  L+DD +++I +        K  E KF +   S+E+E +  +
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDE-------AKKWERKFSDAIQSKEEEIRLKE 2230

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
                 L+ Q RQ+ +  +     ISRLE      K+ + +  Q   ++     + L+   
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHD----KQIWESKAQTEVQLQQKVCDTLQGEN 2286

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS 238
               LS   QLE T H                      L   +Q              EL+
Sbjct: 2287 KELLS---QLEETRH----------------------LYHSSQ-------------NELA 2308

Query: 239  QPRSH-TSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKV-TDAPNK 296
            +  S   SLKD+L+D+S    K           +     D  ++     + ++ TD    
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD--IQNSKFSYEQLETDLQAS 2366

Query: 297  SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD-KDLSGYKGSSTPTKG 355
             E++  +  ++  + + + +  +  EE  +V AI E   + D + K+L            
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQV-AIAELRQQHDKEIKELENLLSQEEEENI 2425

Query: 356  I---ENKAFDRNTESLFEELSSAGSGLI---GDVDEGADLLGMGREVENLILENTQLLET 409
            +   ENK     T  L E L +     I     +D     +   +   + I+ + Q LE 
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485

Query: 410  KNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
            ++   I++ D +  + E   E + L+ E+  ++     L  +N +L+ EL + R   ED 
Sbjct: 2486 RHLSIILEKDQL--IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYR---EDL 2540

Query: 470  RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPA 529
             Q         I  +Q+K+   V++ +     N+Y +   +L+E+    E +R  R   A
Sbjct: 2541 NQVI------TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNA 2592

Query: 530  MQEKKR 535
            +QE+K+
Sbjct: 2593 LQEEKQ 2598



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 91/429 (21%), Positives = 169/429 (39%), Gaps = 50/429 (11%)

Query: 64   VFAQDQEHQV---ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            V AQ++E       L LL+++ ++LIT+ +R     +           S E  K  L+  
Sbjct: 1527 VSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQ-------SLSSSCESLKLALEGL 1579

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE----- 175
             E  E   +++E    +   + +  +E+  EL+KEY  L Q + E + N  E ++     
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY-ENVSNEAERIQHVVEA 1638

Query: 176  -RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
             R +  +L G  +L ST  ++   E+        L   +  +    +K  +   S+Q K 
Sbjct: 1639 VRQEKQELYG--KLRSTEANKKETEKQ-------LQEAEQEMEEMKEKMRKFAKSKQQKI 1689

Query: 235  QELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTP-LKEENEGFVKVTDA 293
             EL +           ++V   G  A     T  S  A++  +   +K E E   K   +
Sbjct: 1690 LELEEENDRLR-----AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1744

Query: 294  --PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSST 351
                K  +S+ ++    Q   NVS            QA +E+T + D   +++     S 
Sbjct: 1745 LMSEKDSLSEEVQDLKHQIEGNVSK-----------QANLEATEKHDNQTNVTEEGTQSI 1793

Query: 352  PTKGIENKAFDRNTESLFEE----LSSAGSGLIGDVDEGADLLGMGREVENLILENTQLL 407
            P +  E  +   +T     E      SA   +  D     ++    ++++ L      L 
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853

Query: 408  ETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAE 467
            E K         L  + + L  +     GEL+ +++   K+   N++++EEL +     E
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913

Query: 468  DARQKAKDD 476
             A ++ KDD
Sbjct: 1914 TAEEE-KDD 1921



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 126/663 (19%), Positives = 237/663 (35%), Gaps = 119/663 (17%)

Query: 83  EQLITQYEREKALRKHAEEKFIE---FEDSQEQEKKDLQTRVESLESQTRQLELKAKNYA 139
           ++L    +R + L +  ++   E     ++ E E+++ +  +E +E +  + +L   N  
Sbjct: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ 339

Query: 140 DQISRLEER-------EAELKKEYNALHQRHTEMIHNYMEH---LERTKLHQLSGSDQLE 189
           +++  L E+       +AEL+  Y+AL Q+H   +     H   L++T     S  D L+
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399

Query: 190 STAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQ-------PRS 242
              +S++ +++            +      AQ   +     Q K +E+SQ        + 
Sbjct: 400 D-QNSKLLQDK------------NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQH 446

Query: 243 HTSLKDELSDVSQGGSKATTPASTANSDVATIPTDT-------------PLKEENEGF-- 287
            T+ +    DV   G++A T  + A+     +  +               LK ENE    
Sbjct: 447 ETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506

Query: 288 --------------------VKVTDAPNKSEISKH------IEVQVAQETRNVSTGSAEN 321
                               + + D  NK   S        +E   +Q+ + +S    E 
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566

Query: 322 EEKSEVQAII----------ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEE 371
           +E  E  A +          E+  E+   K++   +G       I+ K F  +T   F  
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP--IKMKVFLEDTGQDFPL 624

Query: 372 LSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEK 431
           + +  S L     E A      R  E + L N   +E K+        L A  D   C +
Sbjct: 625 MPNEESSLPAVEKEQASTEHQSRTSEEISL-NDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 432 DVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQ-----KAKDDDDSDIPTAQR 486
           D L+     + + +L   +     E+ L +   E  +  Q     K   D++S   TA  
Sbjct: 684 DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743

Query: 487 KRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF 546
           +            ER+Q   ++ EL         ++    N A  E++R   ++      
Sbjct: 744 E------------ERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE------ 785

Query: 547 SSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET-EASLA 605
           S +++     E   +L   A +  V   V +      QL         F  + T   SL 
Sbjct: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQL--------QFSEQSTLIRSLQ 837

Query: 606 SRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLD 665
           S+ + K  +  +    V+    +V+    +L QK  ++T        K   V    + ++
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897

Query: 666 EKD 668
           EKD
Sbjct: 898 EKD 900



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 111/570 (19%), Positives = 215/570 (37%), Gaps = 83/570 (14%)

Query: 100  EEKFIEFEDSQEQEKKDLQTRVES-------LESQTRQLELKAKNYADQISRLEEREAEL 152
            EEK +  E  +EQ +K LQ  + S        + + R L  + K   D  +RL+E+  E 
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222

Query: 153  KKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGI---FPL 209
             KE   +  +  ++     E ++     +L  +DQ ES + S    E P+          
Sbjct: 1223 SKENENIGDQLRQLQIQVRESID----GKLPSTDQQESCS-STPGLEEPLFKATEQHHTQ 1277

Query: 210  PAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANS 269
            P  +  L PD     E   +       L    S   +K +L ++          A     
Sbjct: 1278 PVLESNLCPDWPSHSEDASA-------LQGGTSVAQIKAQLKEIE---------AEKVEL 1321

Query: 270  DVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQ- 328
            ++    T + L +++E   ++ +  NK  +       V+ E    +    +  E S++Q 
Sbjct: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381

Query: 329  AIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN-TESLFEELSSAGSGLIGDVDEGA 387
            A +E   EL    D           K I  K  D +       E  +A + +  ++ E  
Sbjct: 1382 AGLEHLRELQPKLD--------ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQE 1433

Query: 388  DLL-GMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKL 446
            DL+  +  ++E    E+ + ++              ++ E +  K  +Q +L+A   ++ 
Sbjct: 1434 DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493

Query: 447  KLEEKNRELEEELRKARAEAE-------------DARQKAKDDDDSDIPTAQRKRFTRV- 492
            +  ++N+ L+EEL  AR   E              A+ K KD     +   Q +R   + 
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLIT 1553

Query: 493  EMARVLMERNQYKERLMEL-----------QEAVRWTEMIRASR--ENPAMQEKKRSSIW 539
            EM R L+E          L           ++ V+  E +++S+  E+   QEK +  + 
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHK-ELQ 1612

Query: 540  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEE 599
            + +  L  S  N + + E            HV  +V++    L      K ++ +   +E
Sbjct: 1613 KEYEILLQSYENVSNEAE---------RIQHVVEAVRQEKQELY----GKLRSTEANKKE 1659

Query: 600  TEASLASRREQKREQYRQVKAHVQKEDGRV 629
            TE  L    ++  E   +++   + +  ++
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 118/624 (18%), Positives = 235/624 (37%), Gaps = 104/624 (16%)

Query: 20   MSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLR 79
            + ER++GL      E E+   +   + ++     +++ +   D      QE   ++ LL 
Sbjct: 1845 LKERIAGL------EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL- 1897

Query: 80   DDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYA 139
              N+Q+  +  R   L++ AEE           EK DL+   E L +Q  +L     NY 
Sbjct: 1898 --NQQIQEELSRVTKLKETAEE-----------EKDDLE---ERLMNQLAELNGSIGNYC 1941

Query: 140  DQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKE 199
              ++     +A++K   N L +   + +   +  LE  K   +    ++E    S IRKE
Sbjct: 1942 QDVT-----DAQIK---NELLESEMKNLKKCVSELEEEKQQLVKEKTKVE----SEIRKE 1989

Query: 200  RPISLGIFPLPAGDGLLTPDAQKGGETPG--SEQWKFQELSQPRSHTSLKDELSDVSQGG 257
                                 Q   + PG  S   + QEL        LK++  +V Q  
Sbjct: 1990 ----------------YLEKIQGAQKEPGNKSHAKELQEL--------LKEKQQEVKQLQ 2025

Query: 258  SKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 317
                      ++   T+     ++ E++  +++T    K  +++ +E +   +    S  
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEIT----KENLAQAVEHRKKAQAELASFK 2081

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
               ++ +SE   ++     L + K+L   K S       +++  +R  E   E+      
Sbjct: 2082 VLLDDTQSEAARVL--ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK------ 2133

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGE 437
                      +   M  +++ L  E   L ET   + +  N    +V +L    D    +
Sbjct: 2134 -------HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186

Query: 438  LEAVKQAKLKLEEKNRELEEELRKARAEAEDARQ------KAKDDDDSDIPTAQRKRFTR 491
            L A  ++   L++    + +E +K   +  DA Q      + K+D+ S +    R+    
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246

Query: 492  VEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQF--FSRLFSSS 549
            +E  ++ + R ++ +++ E +     TE+    +    +Q + +  + Q      L+ SS
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQ---TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303

Query: 550  SNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPG---------DKSKAFDFLSEET 600
             N   K E  +    +  T  ++ S++K       L G           SK   F  E+ 
Sbjct: 2304 QNELAKLESELKSLKDQLTD-LSNSLEKCKEQKGNLEGIIRQQEADIQNSK---FSYEQL 2359

Query: 601  EASLASRREQKREQYRQVKAHVQK 624
            E  L + RE     + ++    QK
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQK 2383



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 117/645 (18%), Positives = 253/645 (39%), Gaps = 91/645 (14%)

Query: 30   SIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQY 89
            S+  + +R++G Y +++ +  + +++   + +    A++ + + E+  LR   + L ++ 
Sbjct: 2468 SLQNDRDRIVGDY-QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526

Query: 90   EREKA-LRKHAEE--KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLE 146
             +  A L ++ E+  + I  +DSQ+++  ++Q +      Q ++LE K     +++   E
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ------QNKELENKYAKLEEKLKESE 2580

Query: 147  EREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGI 206
            E   +L++ +NAL +   ++     + +E  K+     + Q+     + +++E  + L  
Sbjct: 2581 EANEDLRRSFNALQEEKQDL----SKEIESLKVSISQLTRQV-----TALQEEGTLGLYH 2631

Query: 207  FPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP-------------RSHTSLKDELSDV 253
              L   +     +  +      S Q +  EL +                   LK EL  +
Sbjct: 2632 AQLKVKE----EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL 2687

Query: 254  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 313
                        TA   VA +  D  L E  +  + VT      + +K +  Q+    R+
Sbjct: 2688 HHDAGIMRNETETAEERVAELARD--LVEMEQKLLMVT------KENKGLTAQIQSFGRS 2739

Query: 314  VSTGSAENEEKSEVQAIIESTPELDMD-KDLSGYKGSSTPTKGIENKAFDRNTESLFEEL 372
            +S  S +N      + + E   + D   K+L+  K         E    +R  ++L  E 
Sbjct: 2740 MS--SLQNSRDHANEELDELKRKYDASLKELAQLK---------EQGLLNRERDALLSET 2788

Query: 373  SSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIA---KVDELTC 429
            + + +       E   L  + +  + L+ ++ QLL   + L    N + +    +  L  
Sbjct: 2789 AFSMNS-----TEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843

Query: 430  EKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAED---ARQKAKDDDDSDIPTAQR 486
            E+D L  ELE  +    K EE  +    +   + AE +    A    ++D D  +   + 
Sbjct: 2844 ERDHLWNELEKFR----KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899

Query: 487  KRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS--RENPAMQE-----KKRSSIW 539
             +   +++ + + E +  K +L E Q+  +  ++++    +EN + Q      +   S W
Sbjct: 2900 LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSW 2959

Query: 540  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEE 599
            +   R            +       +   SH+   +++  S+ SQ    K +     S E
Sbjct: 2960 EIHERRMKEQYLMAISDK-------DQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012

Query: 600  TEAS------LASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQ 638
            T AS      L    E  R Q       + +++ R+Q    +  Q
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 7/89 (7%)

Query: 74   ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--ESQTRQL 131
            +L LL    E    Q E +  +    ++ + E   + +  K++LQ   + L  E++ R+ 
Sbjct: 934  QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993

Query: 132  ELKA-----KNYADQISRLEEREAELKKE 155
            +L+A     K    ++SRLEE  A LK E
Sbjct: 994  KLQAALINRKELLQRVSRLEEELANLKDE 1022


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 145/715 (20%), Positives = 285/715 (39%), Gaps = 87/715 (12%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFI----EFEDSQEQEKK------DLQT 119
            E + E+  ++++ ++   +  + +A RK  EEK +    E  D Q Q +       D + 
Sbjct: 847  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906

Query: 120  RVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKL 179
            R E L     QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE T  
Sbjct: 907  RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD-IDDLELTLA 965

Query: 180  HQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQ 239
                     E+   +   +   +   I  L      L    Q+  +   +E+ K   L++
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025

Query: 240  PRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEI 299
             +  T L+ ++ D+   GS         + + A    +  LK   E  + + +  +K ++
Sbjct: 1026 AK--TKLEQQVDDLE--GSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN--DKQQL 1079

Query: 300  SKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPEL-----DMDKDLSGYKGSSTPTK 354
             + +E +  + +  +S    E+E+  E+Q + +   EL     ++ +++   + S    +
Sbjct: 1080 DEKLEKKEFEISNLIS--KIEDEQAVEIQ-LQKKIKELQARIEELGEEIEAERASRAKAE 1136

Query: 355  GIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVENLILENTQL---L 407
              +     R  E + E L  AG      V+      A+   + R++E   L++  +   L
Sbjct: 1137 K-QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195

Query: 408  ETKNA------------LNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 455
              K+A            L  VK  L  +  EL  E D L    EA+ +AK  LE+  R L
Sbjct: 1196 RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSL 1255

Query: 456  EEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV--EMARVLMERNQYKERLMELQE 513
            E+++ + + + E+ ++   D       TAQR R      E +R L E++    +L   ++
Sbjct: 1256 EDQVSELKTKEEEQQRLIND------LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309

Query: 514  AVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTP 573
            A   T+ I   +     + K ++++               ++ E     K     + +  
Sbjct: 1310 AS--TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK-----AELQR 1362

Query: 574  SVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFG 633
            ++ K +S ++Q              + E     R E+  E  +++   +Q+ +  V+A  
Sbjct: 1363 ALSKANSEVAQ-----------WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN 1411

Query: 634  WSLPQKYKQVTNGQGENKMKNLPVPV-----YLRPLDEKDTSMKLWCAVGVNLSGGKTRD 688
                   K  T  + +N++++L + V         LD+K  +          LS  K + 
Sbjct: 1412 AKCASLEK--TKQRLQNEVEDLMLDVERSNAACAALDKKQRNF------DKVLSEWKQKY 1463

Query: 689  GGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSL 743
              +        K+   L TE  K ++  + SLD+L + L+ + K L  Q+E+S L
Sbjct: 1464 EETQAELEASQKESRSLSTELFKVKNVYEESLDQL-ETLRRENKNL--QQEISDL 1515



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 101/508 (19%), Positives = 183/508 (36%), Gaps = 94/508 (18%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKAL--RKHAE---------------EKFIEFEDSQ 110
            +++ + E + LR D E+   Q+E   A   +KHA+               ++ +E E S+
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226

Query: 111  -EQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM--- 166
             + E  DL +  E++      LE   ++  DQ+S L+ +E E ++  N L  +   +   
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTE 1286

Query: 167  IHNYMEHLERTK--LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGG 224
               Y   L+     + QLS S Q  +     ++                       Q   
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH----------------------QLEE 1324

Query: 225  ETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVAT----IPTDTPL 280
            ET           S       L+++  +  +G ++     S ANS+VA       TD   
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1384

Query: 281  KEENEGFVKVTDAPNKSEISKHIEV---------QVAQETRNVSTGSAENEEKSEVQAII 331
            + E     K   A    E  +H+E          +  Q  +N       + E+S      
Sbjct: 1385 RTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAA 1444

Query: 332  ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG 391
                + + DK LS +K     T+  E +A  + + SL  EL                   
Sbjct: 1445 LDKKQRNFDKVLSEWKQKYEETQA-ELEASQKESRSLSTELF------------------ 1485

Query: 392  MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEK 451
               +V+N+  E+   LET    N      I+ + E   E      ELE +K         
Sbjct: 1486 ---KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK--------- 1533

Query: 452  NRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMER----NQYKER 507
             +++E+E  + +A  E+A    + ++   +         + E+ R + E+    +Q K  
Sbjct: 1534 -KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1592

Query: 508  LMELQEAVRWTEMIRASRENPAMQEKKR 535
               + E ++ T        N A++ KK+
Sbjct: 1593 HTRVVETMQSTLDAEIRSRNDALRVKKK 1620



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 93/447 (20%), Positives = 178/447 (39%), Gaps = 90/447 (20%)

Query: 58   LENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALR---------KHAEEKFIEFED 108
            +  L+ +  Q ++ + E++   ++ E  + ++E  K LR            + K  E ++
Sbjct: 1526 IHELEKIKKQVEQEKCEIQAALEEAEASL-EHEEGKILRIQLELNQVKSEVDRKIAEKDE 1584

Query: 109  SQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREA-ELKKEYNALHQRHTEMI 167
              +Q K++    VE+++S T   E++++N A ++ +  E +  E++ + N  ++   E +
Sbjct: 1585 EIDQLKRNHTRVVETMQS-TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESL 1643

Query: 168  HNYMEH---LERTKLH---QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ 221
             NY      L+ T+LH    L G + L+       R+   +   I               
Sbjct: 1644 RNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI--------------- 1688

Query: 222  KGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 281
                    E W   E ++ RS    + EL D S+          T N+ +     +T  K
Sbjct: 1689 -------EELWATLEQTE-RSRKIAEQELLDASE----RVQLLHTQNTSLI----NTKKK 1732

Query: 282  EENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDK 341
             EN+           S++   +E +V QE+RN     AE + K  +        EL  ++
Sbjct: 1733 LEND----------VSQLQSEVE-EVIQESRN-----AEEKAKKAITDAAMMAEELKKEQ 1776

Query: 342  DLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS-GLIGDVDEGADLLGMGREVENLI 400
            D S +            K  ++  + L   L  A    L G   +   L    RE+E  +
Sbjct: 1777 DTSAHLERM-------KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1829

Query: 401  LENTQLLETKNALNIVKNDLIAKVDELTCEK--------------DVLQGELEAVKQAKL 446
             EN Q    +    + K++   +V ELT +               D LQ ++++ K+   
Sbjct: 1830 -ENEQKRNAEAVKGLRKHE--RRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886

Query: 447  KLEEKNRELEEELRKARAEAEDARQKA 473
            + EE++     + RK + E E+A ++A
Sbjct: 1887 EAEEQSNANLSKFRKLQHELEEAEERA 1913



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 175/841 (20%), Positives = 302/841 (35%), Gaps = 183/841 (21%)

Query: 43   DEEVVKELMPLVVAVLENLDSVFAQDQEHQVELEL----LRDDNEQLITQYEREKALRKH 98
            D++ + E +      + NL S    +Q  +++L+     L+   E+L  + E E+A R  
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134

Query: 99   AEEKFIEFEDSQEQEKKDLQTRVESLESQT-RQLELKAKNYAD-QISRLEEREAELKKE- 155
            AE++         +E +++  R+E     T  Q+EL  K  A+ Q  R +  EA L+ E 
Sbjct: 1135 AEKQ----RSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEA 1190

Query: 156  -YNALHQRHT-------EMIHNYM---EHLERTKLHQLSGSDQLESTAHSRIR------- 197
               AL ++H        E I N     + LE+ K      +D L S A +  +       
Sbjct: 1191 MVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEK 1250

Query: 198  --------------KERPISLGIFPLPAGDGLLTPDA-------------------QKGG 224
                          KE      I  L A    L  +A                    K  
Sbjct: 1251 MCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA 1310

Query: 225  ETPGSEQWKFQELSQPRSHTSL--------------KDELSDVSQGGSKATTPASTANSD 270
             T   E+ K Q   + ++  +L              +++  +  +G ++     S ANS+
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370

Query: 271  VA----TIPTDTPLKEENEGFVKVTDAPNKSEISKHIEV---------QVAQETRNVSTG 317
            VA       TD   + E     K   A    E  +H+E          +  Q  +N    
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430

Query: 318  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 377
               + E+S          + + DK LS +K     T+  E +A  + + SL  EL    +
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQA-ELEASQKESRSLSTELFKVKN 1489

Query: 378  GLIGDVDEGADLLGMGREVENLILENTQLLE--TKNALNIVKNDLIAK-VDELTCEKDVL 434
                 +D+   L  + RE +NL  E + L E   +    I + + I K V++  CE    
Sbjct: 1490 VYEESLDQ---LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA 1546

Query: 435  QGELEA---------------VKQAKLKLEEKNRELEEEL-------------------R 460
              E EA               + Q K +++ K  E +EE+                    
Sbjct: 1547 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606

Query: 461  KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQ---YKERLMELQEAVRW 517
            + R+  +  R K K + D +    Q     R+    +   RN     KE  + L +A+R 
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG 1666

Query: 518  TEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKK----------PEPPVNLKYNAP 567
             E +   +E  A+ E++ + +      L+++   T +               V L +   
Sbjct: 1667 QEDL---KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723

Query: 568  TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDG 627
            TS +  + KK  + +SQL           SE  E    SR  +++ +     A +  E+ 
Sbjct: 1724 TSLIN-TKKKLENDVSQLQ----------SEVEEVIQESRNAEEKAKKAITDAAMMAEE- 1771

Query: 628  RVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTR 687
                       K +Q T+   E   KNL   V       KD   +L  A  + L GGK +
Sbjct: 1772 ----------LKKEQDTSAHLERMKKNLEQTV-------KDLQHRLDEAEQLALKGGKKQ 1814

Query: 688  DGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKE----QQKELKNQEELSSL 743
                +       +++ G      K+ + +   L K ++ +KE     +++ KN   L  L
Sbjct: 1815 ----IQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDL 1870

Query: 744  V 744
            V
Sbjct: 1871 V 1871


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 120/625 (19%), Positives = 234/625 (37%), Gaps = 114/625 (18%)

Query: 59  ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQE-KKDL 117
           E  +    ++QE + E +L R+  E+      RE+ LR+  EE+  E +  +EQ+ +++ 
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEE-----RREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 118 QTRVESLESQTRQLELKAKNYADQISRLEE---REAELKKEYNALHQRHTEMIHNYMEHL 174
           Q R E    + +QL  + +   +Q  R E+   RE +L++E     +RH E  H      
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE--EERH-EQKHEQERRE 444

Query: 175 ERTKLHQLSGSDQL----ESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSE 230
           +R K  Q    D L    E+  H + R+++ +                  ++  E    E
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQL------------------KRDQEEERRE 486

Query: 231 QWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKV 290
           +W   E  + R     +++     Q   +                 +  LK + E     
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERR-----------------EQRLKRQEE----- 524

Query: 291 TDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSS 350
                        E ++ Q  R+      E EE+ E     E    L+ ++         
Sbjct: 525 -------------EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR-------- 563

Query: 351 TPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENT--QLLE 408
              + ++ +  +R  + L  E       L  + +E  +      EVE L  E    Q L+
Sbjct: 564 --EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 409 TKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAE--- 465
            +      +  L+   ++    +  L+ E +  ++ +LK EE+   LE+ L++   E   
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 466 ----AEDARQKAKDDDDSDIP-----------TAQRKRFTRVEMARVLMERNQYKERLME 510
               AE+ +++A++   S IP             Q K ++R         R + +E+   
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR 741

Query: 511 LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAP--- 567
            +  ++W E  RA R+    +E++R   WQ+ +   S          PP+  +       
Sbjct: 742 RESELQWQEEERAHRQQQE-EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800

Query: 568 ------TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 621
                      P  +++     Q   ++ K   FL EE +     R +Q +E+   ++  
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQ-RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859

Query: 622 VQK----EDGRVQAFGWSLPQKYKQ 642
            ++    E  R Q + W L ++ K+
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKR 884



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 109/561 (19%), Positives = 217/561 (38%), Gaps = 65/561 (11%)

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKN 137
            LR+  E+ +   ER++      E++F+  E+ +EQ ++  + R + L+    + +L+ + 
Sbjct: 790  LREQRERQLRAEERQQR-----EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 138  YADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIR 197
             A Q+   E+   E ++   +  QR  +     +E   + + H L     L+     ++R
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE----QLR 900

Query: 198  KERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGG 257
            KE+ +          + L   + +K        Q++ +E  Q      L++E     +  
Sbjct: 901  KEQQLLQ-----EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 258  SKATTPASTANSDVATIPTDTPLKEENEGFV-KVTDAPNKSEISKHI--EVQVAQETRNV 314
             +                 D  L+++ E  + +  +   + E  K    E ++ QE   +
Sbjct: 956  RERQ------------YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003

Query: 315  STGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSS 374
                 E   + E +       EL  +++           + ++ +      E   EEL  
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQ--LLREEREKRRLQERERQYREE---EELQQ 1058

Query: 375  AGSGLIGDVDEGA---DLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTC-E 430
                L+G+  E     +L    R+ E L  E  QLL  +            +  E  C E
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE------PEKRRRQERERQCRE 1112

Query: 431  KDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFT 490
            ++ LQ E E     +L  EE+ +   +EL +   E E+ +Q     ++  +   + ++  
Sbjct: 1113 EEELQQEEE-----QLLREEREKRRRQELERQYREEEEVQQ-----EEEQLLREEPEKRR 1162

Query: 491  RVEMARVLMER---NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFS 547
            R E+ R   E     Q +E+L+  ++  R  E  R  RE   +Q +KR   ++   +   
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ--R 1220

Query: 548  SSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSK--AFDFLSEETEASLA 605
            S      +PE    ++ N        + + R    SQL   +S+      L E+ E    
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD-- 1278

Query: 606  SRREQKREQYRQVKAHVQKED 626
              REQ+R +++Q   H  +E+
Sbjct: 1279 --REQERRRWQQRDRHFPEEE 1297



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 137/714 (19%), Positives = 265/714 (37%), Gaps = 98/714 (13%)

Query: 59  ENLDSVFAQDQEHQVELE--LLRDDNEQLITQ--------YEREKALRKHAEEKF----I 104
           E  D VF +++E +      +LR + E+L  +         E E+ LRK   ++      
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291

Query: 105 EFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHT 164
           E E  Q++ +++ Q R +  E +  Q E + +    +  + E RE +L++E     +R  
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ---EERRE 348

Query: 165 EMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGG 224
           + +    E   R    Q    +Q E     ++R+E+ +          +  L  + Q   
Sbjct: 349 QQLRREQEEERR---EQQLRREQEEERREQQLRREQQL--------RREQQLRREQQLRR 397

Query: 225 ETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEEN 284
           E     + + +   Q R    L+ E     +   +              +  +   +EE 
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE---QEER 454

Query: 285 EGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLS 344
             ++K      + E  +H      QE R       + EE+ E    +E     +  +   
Sbjct: 455 RDWLK-----REEETERH-----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504

Query: 345 GYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENT 404
                    +  +        E L + L S    L  + +E  + L + RE E  + +  
Sbjct: 505 QQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQL-LKREEEKRLEQER 562

Query: 405 QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 464
           +    K      ++ L+ + +E   ++  L+ E E   + +LK EE  R  +EE R+ R 
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQR--LKREQEERLEQRLKREEVERLEQEERREQRL 620

Query: 465 E----AEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERL-----MELQEAV 515
           +     E+ RQ+    ++ +    Q+ R  + E     ++R + +ERL      E +E  
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680

Query: 516 RWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSV 575
           R  E+    +E    + K R   WQ+  +L S +     K        Y+ P        
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQW--QLESEADARQSK-------VYSRPR------- 724

Query: 576 KKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR----QVKAHVQKEDGRVQA 631
           K+      Q   +K +  +   +  E   A R++Q+ EQ R    Q +A  + E GR Q 
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR-QR 783

Query: 632 FGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGS 691
                P + ++    + E + +      +L   +EK+   +            + R+   
Sbjct: 784 LSARPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRR----------QRRERE--- 828

Query: 692 VVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVW 745
                   K++  L+ E   QR      L + +  L+E Q+  ++QE+     W
Sbjct: 829 --------KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 96/480 (20%), Positives = 186/480 (38%), Gaps = 56/480 (11%)

Query: 67   QDQEHQV-ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLE 125
            Q+QE Q  E E L+ + EQL+ + EREK  R+  E ++ + +  Q++E++ L    E   
Sbjct: 924  QEQERQYREEEQLQQEEEQLLRE-EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 126  SQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGS 185
             Q R+     K Y ++    +E E  L++E     ++  E  +   + L++ +  QL   
Sbjct: 983  RQERE-----KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE-EQLLRE 1036

Query: 186  DQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS-QPRSHT 244
            ++ +     R R+ R            + L   + Q  GE    E  + QEL  Q R   
Sbjct: 1037 EREKRRLQERERQYR----------EEEELQQEEEQLLGEE--RETRRRQELERQYRKEE 1084

Query: 245  SLKDE----LSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS 300
             L+ E    L +  +   +          +      +  L+EE E          + E+ 
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE-------KRRRQELE 1137

Query: 301  KHI--EVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN 358
            +    E +V QE   +     E   + E++       EL  +++           +  E 
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE--QLLREEQEKRRQER 1195

Query: 359  KAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGR-EVENLILENTQLLETKNALNIVK 417
            +   R  E L  +          D D+ +DL      E EN + +N    + +      +
Sbjct: 1196 ERQYREEEELQRQKRKQ---RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR------E 1246

Query: 418  NDLIAKVDELTCEKDVLQGELEAV--KQAKLKLEEKNRELEEELRKARAEAEDARQKAKD 475
            N+   ++++        Q +L+ +  +Q +   E++ R  ++  R    E +  R++ K+
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306

Query: 476  DDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKR 535
                    A+R+     E  ++L E  + K R  E     R  E +   RE   ++ ++R
Sbjct: 1307 --------AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 83   EQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQI 142
            EQ +   ERE+ LR+  + KF E E    ++++D + R E  E Q R+ E + K   ++ 
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE--EQQVRRQERERKFLEEEQ 1453

Query: 143  SRLEEREAELKKEYNALHQRHTEMIH 168
               +ER  + ++E   L +R  + +H
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLH 1479



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 40/191 (20%), Positives = 85/191 (44%), Gaps = 10/191 (5%)

Query: 69   QEHQVELELLRD----DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL 124
            QE Q +L   RD    ++EQL+ + E ++  R+  + KF+E E    +++++ Q R    
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR-HDR 1665

Query: 125  ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSG 184
            + + R+ E   +   +Q  R +ER+ + ++E   L ++  E    +++  ++ +  +L  
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE--RKFLQEEQQLRRQELER 1723

Query: 185  SDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQE---LSQPR 241
              + E        +E+      +     +  L P+ ++          KF+E   L Q R
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783

Query: 242  SHTSLKDELSD 252
                L+ + SD
Sbjct: 1784 EEQQLRSQESD 1794



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 30/135 (22%), Positives = 60/135 (44%), Gaps = 4/135 (2%)

Query: 68   DQEHQVELELLRD--DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLE 125
            ++E Q+  E  R   + EQL+ + E ++  R+  + KF+E E    ++++D + R + L 
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509

Query: 126  SQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGS 185
            SQ  + E K      Q+ R + +   L++E     Q   +      +   R +       
Sbjct: 1510 SQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 186  DQLESTAHSRIRKER 200
            ++ + +   R RK R
Sbjct: 1568 EEQQLSRQERDRKFR 1582



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 32/148 (21%), Positives = 66/148 (44%), Gaps = 8/148 (5%)

Query: 59   ENLDSVFAQDQEHQVELE-LLRDDNE-----QLITQYEREKALRKHAEEKFIEFEDSQEQ 112
            + L+  + +++E Q E E LLR++ E     +L  QY  E+ L++  E+   E ++ + Q
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 113  EKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYME 172
            E++      E L+ Q R+   + ++    +    E E E     N ++ +  E  +    
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE--NEQFR 1251

Query: 173  HLERTKLHQLSGSDQLESTAHSRIRKER 200
             LE ++L        L+     +  ++R
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDR 1279



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 43/174 (24%), Positives = 82/174 (47%), Gaps = 19/174 (10%)

Query: 41   RYDEEVVKELMPLVVAVLENLDSVFAQDQEHQV-ELELLRDDNEQLITQYEREKALRKHA 99
            R +EE+ +E   L+    E  +    Q+ E Q  + + L+ + EQL+ + EREK   +  
Sbjct: 991  REEEELQQEEEQLL---REEREKRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQER 1046

Query: 100  EEKFIEFEDSQEQEKKDL-----QTRVESLESQTRQLELKAKNYADQISRLE-------E 147
            E ++ E E+ Q++E++ L       R + LE Q R+ E + +   +Q+ R E       E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQE 1105

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERP 201
            RE + ++E   L Q   +++    E   R +L +    ++       ++ +E P
Sbjct: 1106 RERQCREE-EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 39/225 (17%), Positives = 88/225 (39%), Gaps = 10/225 (4%)

Query: 430 EKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF 489
           E+++ +GE ++ KQ +L+  ++ R  EE  R+ +   E   ++A+++        + + F
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204

Query: 490 TRVEMARVLMERNQYKERLMELQEAVRWT-EMIRASRENPAMQEKKRSSIWQFFSRLFSS 548
              E  R        +  L+EL+   R   +  R  R++   QE++    W+    +   
Sbjct: 205 PDEEQLR--------RRELLELRRKGREEKQQQRRERQDRVFQEEEEKE-WRKRETVLRK 255

Query: 549 SSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRR 608
                ++ EP    +       +    ++      Q    + +      +        RR
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 609 EQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMK 653
           EQ+ E+  Q +   Q+E+ R Q       ++ +Q    + E + +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 41/181 (22%), Positives = 81/181 (44%), Gaps = 19/181 (10%)

Query: 32   YREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE--HQVELELLRD--------D 81
            +RE E+ + R + E  K L        + L+  F ++++   + E E LR         +
Sbjct: 1693 FREEEQQLRRQERER-KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 82   NEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQ 141
             EQL  + E ++  R+  + KF E E+   QE+++ Q R +  + + R+ E   +   +Q
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810

Query: 142  ISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERP 201
              R ++R+ + + E   L     E      + L + +  Q    +Q  +   SR R+E+ 
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE------QRLRQERDRQYRAEEQFATQEKSR-REEQE 1863

Query: 202  I 202
            +
Sbjct: 1864 L 1864



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 11/144 (7%)

Query: 62  DSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRV 121
           + ++ Q QE Q E E  R + EQL       ++ + H  E+F + E  + +E  +L+ + 
Sbjct: 171 EELWRQRQEWQ-EREERRAEEEQL-------QSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 122 ESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM---IHNYMEHLERTK 178
              + Q R+         ++     +RE  L+KE   L +   +    +    E L + +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 179 LHQLSGSDQLESTAHSRIRKERPI 202
             +L    Q E     R+R+E+ +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQL 306



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 11/136 (8%)

Query: 67   QDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLES 126
            + Q H+ E +    + E  + + ERE+ LR   + KF E E+   QE ++ Q R +  + 
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE-EEQLLQEGEEQQLRRQERDR 1691

Query: 127  QTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL-ERTKLHQLSGS 185
            + R+ E        Q  R +ERE +  +E   L ++  E      E L + T+  QL   
Sbjct: 1692 KFREEE--------QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743

Query: 186  DQLES-TAHSRIRKER 200
            ++        ++R ER
Sbjct: 1744 ERYRKILEEEQLRPER 1759



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/126 (24%), Positives = 57/126 (45%), Gaps = 20/126 (15%)

Query: 81   DNEQLITQYEREKALRKHAEEKFIEFEDS---QEQEKKDLQTRVESLESQTRQLELKAKN 137
            + EQL  + E ++  R+  + KF   E     QEQE+K ++   + L  Q  Q +L+   
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE-QQLRRQEGQQQLR--- 1614

Query: 138  YADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH---QLSGSDQLESTAHS 194
                    +ER+ + +++   L +R  + +H   +  +R  L    QL   ++ +   H 
Sbjct: 1615 --------QERDRKFREDEQLLQEREEQQLHR--QERDRKFLEEEPQLRRQEREQQLRHD 1664

Query: 195  RIRKER 200
            R RK R
Sbjct: 1665 RDRKFR 1670



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 32/146 (21%), Positives = 62/146 (42%), Gaps = 6/146 (4%)

Query: 58  LENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDL 117
           L+  +    +DQE +   E  RD   +   Q E E+  R+H        ++   +E++ L
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRW--QLEEERKRRRHTLYAKPALQEQLRKEQQLL 906

Query: 118 QTRVESL---ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL 174
           Q   E L   E + R+ + + + Y ++  +L++ E +L +E     +R         +  
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREE-EQLQQEEEQLLREEREKRRRQERERQYRKDKK 965

Query: 175 ERTKLHQLSGSDQLESTAHSRIRKER 200
            + K  QL G +  +     R +K R
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYR 991



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 29/128 (22%), Positives = 58/128 (45%), Gaps = 16/128 (12%)

Query: 67   QDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLES 126
            +D++ Q E +LLR          ERE+  R+   ++    E+   QE+++   R +  + 
Sbjct: 1310 RDRKSQEEKQLLR---------EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360

Query: 127  QTRQLELK----AKNYADQISRLEEREAE---LKKEYNALHQRHTEMIHNYMEHLERTKL 179
            + R+ EL+     + + ++  RL  +E E   LK+E     Q   + +    +   R + 
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420

Query: 180  HQLSGSDQ 187
             QLS  ++
Sbjct: 1421 QQLSRQER 1428



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 31/148 (20%), Positives = 63/148 (42%), Gaps = 20/148 (13%)

Query: 69   QEHQVELELLRD----DNEQLITQYEREKALRKHA--------EEKFIEFEDSQEQEK-- 114
            QE + +L   RD    + EQ +++ ER++  R+          E KF+E E    QE+  
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461

Query: 115  --KDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYME 172
              ++ +  ++  E Q    + + + + ++  +L  +E + K     L  +  E    ++E
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE--RKFLE 1519

Query: 173  HLERTKLHQLSGSDQLESTAHSRIRKER 200
              E  +LH+     +         R+ER
Sbjct: 1520 --EEQQLHRQQRQRKFLQEEQQLRRQER 1545



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 30/153 (19%), Positives = 64/153 (41%), Gaps = 11/153 (7%)

Query: 59  ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
           E L S    + E   + E LR      + +  RE+  ++  E +   F++ +E+E +  +
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250

Query: 119 T----RVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQ---RHTEMIHNYM 171
           T      E L+ +  Q + + +   +Q+ +LE +E   +++     Q   R  + +    
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310

Query: 172 EHLER----TKLHQLSGSDQLESTAHSRIRKER 200
           E   R     +  Q    +Q E     ++R+E+
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQ 343



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 20/130 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLR--------DDNEQLITQYERE--KALRKHAEEKFIEFED 108
            ++L  +  + QE   E E  R         + EQL  + ++E  +  RK  EEK +  E+
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 109  SQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
             +E+ ++      +  + + R+ E   +   +Q  R +ER+ + ++E      RH E   
Sbjct: 1325 REEKRRR------QETDRKFREEEQLLQEREEQPLRRQERDRKFREE----ELRHQEQGR 1374

Query: 169  NYMEHLERTK 178
             ++E  +R +
Sbjct: 1375 KFLEEEQRLR 1384


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 102/527 (19%), Positives = 204/527 (38%), Gaps = 72/527 (13%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
            ENL +   ++QE   ELE++    E ++ + E+EK   K      +E   +Q    K+L 
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ---LKELN 2451

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM---IHNYMEHLE 175
             RV +L +     + K +N + Q+  LE  +A+L +  +     +  +   ++  ++ +E
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                    G  +LE       +K+  IS     +   + L++  +Q  GE    + WK Q
Sbjct: 2512 -------DGKQKLE-------KKDEEISRLKNQIQDQEQLVSKLSQVEGE---HQLWKEQ 2554

Query: 236  ELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPL-KEENEGFVKVTDAP 294
             L        L+ ++  +    +          S    +  +  L K +   FV+  +  
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614

Query: 295  NKSEISKHIEV-QVAQETRNV--STGSAENEEKSEVQAIIE------------STPELDM 339
               E     E+ ++AQ+T  +       +N    E+Q ++E            +    ++
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674

Query: 340  DKDLSGYKGSSTPTKG-------------------------IENKAFDRNTESLFEELSS 374
             K L          +G                           NK ++   ++  E+L+S
Sbjct: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734

Query: 375  AGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVL 434
                L     E   L     E+ N +   TQ+LE    L   K D +  V++L  E +  
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILE---ELKKTKMDNLKYVNQLKKENERA 2791

Query: 435  QGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEM 494
            QG+++ + ++  +LEE+   L++EL + +A  E  +     D   D  T + K   +  +
Sbjct: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKEL-KETL 2850

Query: 495  ARVLMERNQYKER----LMELQEAVRWTEMIRASRENPAMQEKKRSS 537
                 E ++Y ++    L+  ++  +  EM+     +   Q+ K+ S
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 121/634 (19%), Positives = 244/634 (38%), Gaps = 112/634 (17%)

Query: 45   EVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFI 104
            E + EL       L  +D +  Q+  H ++L +    NE L                + +
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENL----------------RLL 1787

Query: 105  EFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHT 164
               + ++++ + L   ++ L+S+    E++     +    LE+   ELKKE + L ++  
Sbjct: 1788 HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847

Query: 165  EMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGG 224
                ++ E L+R +  +   SD LE  A    R++            GD +         
Sbjct: 1848 YFSCDHQELLQRVETSEGLNSD-LEMHADKSSRED-----------IGDNV--------- 1886

Query: 225  ETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTD-TPLKEE 283
                ++ WK + L        +++ELS +    +     A    +D+  + T+   L+++
Sbjct: 1887 -AKVNDSWKERFL-------DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938

Query: 284  NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 343
            NE   KV        +    E+ V    RN   G  +   K        S    +  ++L
Sbjct: 1939 NENKQKVI-------VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL 1991

Query: 344  SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGD----------VDEGADLLGMG 393
              ++        +        TE L + LSS  S L+ D          +++ +  L + 
Sbjct: 1992 ESHQSECLHCIQVAEAEVKEKTE-LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050

Query: 394  R-EVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKN 452
            + E+EN I    QL + K  L      L A++ E   EK  +   LEA    K +   + 
Sbjct: 2051 KCELENQI---AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107

Query: 453  RELEEELRKARAEAEDARQKAKDDDDSDIPTAQ------------RKRFTRVEMARVLME 500
               +EE+ + R   E  R + + D+   +  A+            + +   +E    + E
Sbjct: 2108 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE 2167

Query: 501  RNQ----------------YKERLMELQEAVRWTEM----IRASRENPAMQ-EKKRSSIW 539
             NQ                 K ++ E+  +++  E+    +R+ +EN   Q ++K+  + 
Sbjct: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS 2227

Query: 540  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTS--HVTPSVKKRSSTLSQLPGDKSKAFDFLS 597
            +    L S  S   +K +  + +K  + T+   +   +K+ +  ++ L GD+      + 
Sbjct: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE-----IM 2282

Query: 598  EETEASLASRREQKREQYRQVKAHVQKEDGRVQA 631
            + TE SL    +   E+  Q++  ++K   R++A
Sbjct: 2283 KATEQSL----DPPIEEEHQLRNSIEKLRARLEA 2312



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 109/507 (21%), Positives = 204/507 (40%), Gaps = 76/507 (14%)

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LD +  + +E   ELE  + +    I   E E   +    +          ++K  LQ +
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH---NYMEHLERT 177
            ++SLE  ++ L L      +QI++L + +  L KE  +L  R +E  +   N  + LE  
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096

Query: 178  KLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQEL 237
             + +   + +L ST     +  R I      + A +      A+K  E            
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKE------------ 2144

Query: 238  SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKS 297
             + R + SLKD++ ++ +                     +  + EEN+  V + DA N  
Sbjct: 2145 -RERENDSLKDKVENLER---------------------ELQMSEENQELV-ILDAENSK 2181

Query: 298  EISKHIEVQVAQETRNVSTGSAE-----NEEKSEVQAIIESTPEL-DMDKDLSGYKGSST 351
               + ++ Q+ +  R++     +     +E+++  + I E   +L ++DK LS +K    
Sbjct: 2182 AEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2241

Query: 352  PTKGIE------NKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQ 405
              +  E      +K      ++  +EL+ A + L GD +    +    + ++  I E  Q
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI---MKATEQSLDPPIEEEHQ 2298

Query: 406  LLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAE 465
            L   +N++  ++  L A   +  C   VLQ   E+   A L L+ +   LE EL  AR  
Sbjct: 2299 L---RNSIEKLRARLEADEKKQLC---VLQQLKESEHHADL-LKGRVENLERELEIARTN 2351

Query: 466  AEDARQKAKDDDDSDIPTAQRKR---------------FTRVEMARVLMERNQYKERLME 510
             E A  +A ++   ++ T + K                  R E   +  E  + +ER+ E
Sbjct: 2352 QEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410

Query: 511  LQEAVRWTEMIRASRENPAMQEKKRSS 537
            L+      E I   +E   +Q K++SS
Sbjct: 2411 LEIINSSFENILQEKEQEKVQMKEKSS 2437



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 83/376 (22%), Positives = 145/376 (38%), Gaps = 64/376 (17%)

Query: 395 EVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRE 454
           E  NL  EN +L+E   +L   K  +  ++     + +  +G+L + K       ++  +
Sbjct: 61  EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK-------KQIEK 113

Query: 455 LEEELRKARAEAEDARQKAKDDDDSDIP-TAQRKRFTRVEMARVLMERNQYKERLMELQE 513
           LE+EL++ ++E E ++Q A+  D S  P    +K FT           ++Y++   +  +
Sbjct: 114 LEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK 173

Query: 514 AVRWTEMIRASRENPAMQEKKRSSI----------------------WQFFSRLFSSSSN 551
            V   E  R   E  A+Q KK S                        WQ        SSN
Sbjct: 174 EVE--ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231

Query: 552 TTKKP-EPPVNLKYNAPTSHVTPS-----VKKRSSTLSQLPGDKSKAFDFLSEETEASLA 605
           + + P     +  Y +    VTPS     + KR +  S      S     L ++ +A   
Sbjct: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSS---PHLLDQLKAQNQ 288

Query: 606 SRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLD 665
             R +  E   +++ H ++  G+V  F     Q  K       + K+ N      +R   
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348

Query: 666 EKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQ 725
           + D +   + A+   L                       L  + S QR  ++S+   L+Q
Sbjct: 349 QYDQASTKYTALEQKLK---------------------KLTEDLSCQRQNAESARCSLEQ 387

Query: 726 ELKEQQKELKNQEELS 741
           ++KE++KE   QEELS
Sbjct: 388 KIKEKEKEF--QEELS 401



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 104/486 (21%), Positives = 201/486 (41%), Gaps = 62/486 (12%)

Query: 90  EREKALRKHAEEKFIEFE---DSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLE 146
           E ++ L   A +K  E E   D  ++EK+  Q +++SLE+  ++ + K +N   + + L+
Sbjct: 7   EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66

Query: 147 EREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQ---LSGSDQLESTAHSRIRKERPIS 203
                L +   +L +   ++ H       +    +    SG  Q+E       R +  + 
Sbjct: 67  RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE 126

Query: 204 LGIFPLPAGDGLLTP--DAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKAT 261
                  + D  L P    QK   TP         L+  + ++  K E  D+ +  +K  
Sbjct: 127 RSQQAAQSADVSLNPCNTPQKIFTTP---------LTPSQYYSGSKYE--DLKEKYNKEV 175

Query: 262 TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAEN 321
                  ++V  +      K+ ++   + T   N  +I++H      Q + +V +   E 
Sbjct: 176 EERKRLEAEVKALQA----KKASQTLPQAT--MNHRDIARH------QASSSVFSWQQE- 222

Query: 322 EEKSEVQAIIESTPELDMDKDLSGYKGSS--TPTKGI-------ENKAFDRNTES--LFE 370
           +  S + +  + TP +  D   S + G    TP++          N +F  N+ S  L +
Sbjct: 223 KTPSHLSSNSQRTP-IRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD 281

Query: 371 ELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCE 430
           +L +    L   ++E  +L   G E E +  +  +  E +  L   K +LI K   L   
Sbjct: 282 QLKAQNQELRNKINE-LELRLQGHEKE-MKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339

Query: 431 KDVLQGELEAVKQAKLK---LEEKNRELEEELRKARAEAEDAR------QKAKDDDDSDI 481
           +D L        QA  K   LE+K ++L E+L   R  AE AR       K K+ +  + 
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399

Query: 482 PTAQRKRFTRVEMARVLMERNQYKERL-MELQEAVRWTEMIRASREN-PAMQEKKRSSIW 539
            + Q++ F  ++      E  Q K RL  ELQ+A     +++A  +   +++++  +++ 
Sbjct: 400 LSRQQRSFQTLD-----QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454

Query: 540 QFFSRL 545
           +F  +L
Sbjct: 455 EFKQKL 460



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 96/473 (20%), Positives = 179/473 (37%), Gaps = 81/473 (17%)

Query: 54   VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFE---DSQ 110
            +++ LE     + + +E +      + +NE+L+TQ E EK   ++ + K    E    +Q
Sbjct: 598  LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK---ENLQSKINHLETCLKTQ 654

Query: 111  EQEKKDLQTRVESLESQTRQLELKAKNYAD---------QISRLEEREAELKKEYNALHQ 161
            + +  +   RV +LE     L ++ +N  +         +  +L   E + K E++   Q
Sbjct: 655  QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS--DQ 712

Query: 162  RHTEMIHNY-------------MEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFP 208
            +H + I N              +EH  +   +++   D+     H+     R +      
Sbjct: 713  KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL------ 766

Query: 209  LPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKAT-----TP 263
            L + D  L  +          +Q       QP  H S  + + +     S+ +       
Sbjct: 767  LKSKDASLVTNEDHQRSLLAFDQ-------QPAMHHSFANIIGEQGSMPSERSECRLEAD 819

Query: 264  ASTANSDVATIPTDT------PLKEENEGFVKVTD--APNKSEISKHI-------EVQVA 308
             S  NS +     D+        K+ N    K  +     K EI +++       +  VA
Sbjct: 820  QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 879

Query: 309  QETRNVS-----TGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDR 363
            + ++ +S     T + +N     + A+     EL +  D    K  +   +  E K  + 
Sbjct: 880  ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLND----KVETEQAEIQELKKSNH 935

Query: 364  NTESLFEELSSAGSGLIGDVDEGADLLGMG-REVENLILENTQLLETKNALNIVKNDLIA 422
              E   +EL      L  +  E + ++ +  RE+E L  EN  L E   +LN  K +LI 
Sbjct: 936  LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995

Query: 423  KVDELT---CEKDVLQGEL-EAVKQAKL----KLEEKNRELEEELRKARAEAE 467
            K +       E++    EL +  KQ KL    + EE     E+  +K +A  E
Sbjct: 996  KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 27/146 (18%), Positives = 61/146 (41%), Gaps = 2/146 (1%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            E+ ++ L     ++ + L+ + +  +  + ELEL + D    + +  +  A     + + 
Sbjct: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625

Query: 104  IEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRH 163
             E      + +++L      L  + + L  + K+  DQ+  L    +ELKK  + +H+  
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685

Query: 164  TEMIHNYMEHLE--RTKLHQLSGSDQ 187
             E      E +   + +LH+     Q
Sbjct: 2686 VEKEGKVREEIAEYQLRLHEAEKKHQ 2711



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 71/307 (23%), Positives = 116/307 (37%), Gaps = 34/307 (11%)

Query: 107  EDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM 166
            E   EQ    L    ES  +    L L  K      + L+E+   L+ E+  LH +H +M
Sbjct: 1371 EQPNEQHPVSLAPLDES--NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428

Query: 167  IHNYME---HLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG 223
                 E   +++  K   L  S  L +     + KE  + L    +P+      PD+   
Sbjct: 1429 SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV-KEMQLGLEEGLVPSLSSSCVPDSS-- 1485

Query: 224  GETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEE 283
                         L     + +L ++  D+S   +     A +AN         + L+EE
Sbjct: 1486 ---------SLSSLGDSSFYRALLEQTGDMSLLSN--LEGAVSANQCSVDEVFCSSLQEE 1534

Query: 284  NEGFVKVTDAPNK--SEISKHIEVQVAQ----ETRNVSTGSAENEEKSEVQAIIES-TPE 336
            N    +   AP K   E+    EV        E +  S G  +N+E  E++ ++ S   E
Sbjct: 1535 NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQE 1594

Query: 337  LD------MDKDLSGYKGSSTPTKGIENK--AFDRNTESLFEELSSAGSGLIGDVDEGAD 388
            LD      + ++    +  ++ T  +E+K  A  + TE L  EL  A   L G       
Sbjct: 1595 LDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRS 1654

Query: 389  LLGMGRE 395
            LLG+  E
Sbjct: 1655 LLGIDTE 1661



 Score = 32.0 bits (71), Expect = 4.0
 Identities = 71/433 (16%), Positives = 157/433 (36%), Gaps = 58/433 (13%)

Query: 70   EHQVELELLRDDNEQLITQYEREKAL--------RKHAEEKFIEFEDSQEQEKKD----- 116
            E++   +LL+  +  L+T  + +++L          H+    I  + S   E+ +     
Sbjct: 759  EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818

Query: 117  ---------LQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMI 167
                     LQ RV+SLE      +    +   Q   L + + E+++      Q H   +
Sbjct: 819  DQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV 878

Query: 168  HNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETP 227
                + + + +    +  + +  T  +   KE+ + L        D + T          
Sbjct: 879  AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL------LNDKVET---------- 922

Query: 228  GSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGF 287
              EQ + QEL   +S+  L+D L ++       +      +S ++    +     +  G 
Sbjct: 923  --EQAEIQELK--KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978

Query: 288  VKVTDAPNKSE----ISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 343
            +K  +A    E    I K        + R  S     ++ K E   +++   E       
Sbjct: 979  LKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG----- 1033

Query: 344  SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILEN 403
            + Y+  S   K  + K  +   E L  E +S       ++++  +      +     L  
Sbjct: 1034 NAYEDLSQKYKAAQEK--NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE---FLTK 1088

Query: 404  TQLLETKNALNIVKNDLIAKV--DELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRK 461
                E +N   +++ + + +    E+T  ++  + E   +KQ  + L+E+  ++++E+  
Sbjct: 1089 LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND 1148

Query: 462  ARAEAEDARQKAK 474
               E E   +  K
Sbjct: 1149 LLQENEQLMKVMK 1161


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 124/638 (19%), Positives = 248/638 (38%), Gaps = 59/638 (9%)

Query: 78  LRDDNEQLITQYEREKALRKHAEEKFIE-FEDSQEQE--KKDLQTRVESLESQTRQLELK 134
           L DD  + +++  R  A  K A E+  E   ++Q+QE     ++ R++ LE + R     
Sbjct: 178 LGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTEREL 237

Query: 135 AKNYADQIS--------RLEEREAELKKEYNALHQ--RHTEMIHNYMEH---LERTKLHQ 181
            +   DQ+          L+++EA+  +   A+    R TE   N +E    L R  L+Q
Sbjct: 238 VERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQ 297

Query: 182 LSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPR 241
             GS +        +R +   + G               Q   +    E W+F+     R
Sbjct: 298 SEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRR-GVER 356

Query: 242 SHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFV--KVTDAPNKSEI 299
               L+ ++SD+     +     S   S++  +      K++ +  +  +V +   + E 
Sbjct: 357 EKQDLEKQMSDL-----RVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELEN 411

Query: 300 SKHIEVQVAQETRNVST--GSAENEEKSEVQAIIESTPEL-DMDKDLSGYKGSSTPTKGI 356
            +  ++Q+    + +     + E E K     I E T    D  K    Y      ++ +
Sbjct: 412 GEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEAL 471

Query: 357 ENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIV 416
           + +A  R  +   +   S     +        L      V+ L  +N Q+L+ K+ L   
Sbjct: 472 KEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL--- 528

Query: 417 KNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDD 476
           K  L A + ++    + L+ EL  V   +   EE+    EE+LR  ++   D   + K+ 
Sbjct: 529 KTQLYAALQQI----ENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNS 584

Query: 477 DD------------SDIPTAQR--KRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIR 522
            D            S I +  +  K     E+A +   + Q K +L+E+QE+++    IR
Sbjct: 585 LDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIR 644

Query: 523 ASRENP-AMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPV-NLK-----YNAPTSHVTPSV 575
           A   N  A +E+ + ++ +  S L + + +  ++    +  LK     +      +T S+
Sbjct: 645 ADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSL 704

Query: 576 KKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWS 635
           +   +   Q   +  K F     E E  + + + +  E+    K H     G+++     
Sbjct: 705 QSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIH----RGQLEKLKSQ 760

Query: 636 LPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKL 673
             +  +++T  + ENK   L        L+E++  + +
Sbjct: 761 CDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISI 798



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 60/269 (22%), Positives = 104/269 (38%), Gaps = 53/269 (19%)

Query: 76  ELLRDDNE---QLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE 132
           ++L++ +E   QL    ++ + LRK   +   +    QE+E    + ++  ++S    LE
Sbjct: 520 QILKEKDELKTQLYAALQQIENLRKELNDVLTK-RALQEEELHSKEEKLRDIKSHQADLE 578

Query: 133 LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTA 192
           L+ KN  D I RL   E+ELKK+     Q   E  H   E  E  K      +  LE   
Sbjct: 579 LEVKNSLDTIHRL---ESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE--M 633

Query: 193 HSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSD 252
              I+    I   +             A K  E             + R+  ++  +LSD
Sbjct: 634 QESIKDLSAIRADL-------------ANKLAE-------------EERAKKAVLKDLSD 667

Query: 253 VSQGGSKATTPASTANSDVATIPTDTPLKEE-----------NEGFVKVTDAPNKSEISK 301
           +       T  A + + + ATI T   L+ +           +   VK     N  E+ K
Sbjct: 668 L-------TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMK 720

Query: 302 HIEVQVAQETRNVSTGSAENEEKSEVQAI 330
           H + + ++   ++ T  AE+ E+  +  I
Sbjct: 721 HFKKEKSEAENHIRTLKAESLEEKNMAKI 749



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 12/86 (13%)

Query: 68  DQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQ 127
           D  H++E EL +    Q  +Q + EKA   H EE+  E + SQ Q+K  L      LE Q
Sbjct: 586 DTIHRLESELKKQSKIQ--SQMKVEKA---HLEEEIAELKKSQAQDKAKL------LEMQ 634

Query: 128 TRQLELKAKNYADQISRLEEREAELK 153
               +L A   AD  ++L E E   K
Sbjct: 635 ESIKDLSAIR-ADLANKLAEEERAKK 659


>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
          Length = 898

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 115/597 (19%), Positives = 241/597 (40%), Gaps = 90/597 (15%)

Query: 62  DSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRV 121
           D + AQD   +  ++ L  +  Q + Q  ++    +  +E  +      E+E  DL+   
Sbjct: 270 DQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEK 329

Query: 122 ESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH-------NYMEHL 174
           E+LE + R    + +   ++I +L + +  L + Y       T +I        +   H+
Sbjct: 330 ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHV 389

Query: 175 ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGL------LTPDAQKGGE--- 225
            + K  Q     +++S   ++ + +   +         D +      +    Q+  E   
Sbjct: 390 IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKS 449

Query: 226 ---------TPGSEQWKFQELS-QPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIP 275
                    T G  + + QE S Q   H +   EL D+ +   +      T  + V  + 
Sbjct: 450 NELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLE 509

Query: 276 TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTP 335
            D  L+ E+E             +SK+ E+               N +K+E+Q +++   
Sbjct: 510 -DERLRTEDE-------------LSKYKEII--------------NRQKAEIQNLLDKVK 541

Query: 336 ELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGRE 395
             D  ++              + +   +  E+L EE+ S  S LI D+ +  D+ G  R+
Sbjct: 542 TADQLQE--------------QLQRGKQEIENLKEEVESLNS-LINDLQK--DIEG-SRK 583

Query: 396 VENLILENTQLLETKNA-LNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRE 454
            E+ +L  T+ L +KNA L    N L ++ D+++C +  LQ + E +KQ  + LE +  +
Sbjct: 584 RESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK 643

Query: 455 LEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEA 514
            EEELRK   +   A    +  +   + T Q +      + +     +  K+   +LQ+A
Sbjct: 644 -EEELRKEEVQTLQAELACRQTEVKALST-QVEELKDELVTQRRKHASSIKDLTKQLQQA 701

Query: 515 VRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPS 574
            R  + + +        +K+ SS+    S   S ++ ++ +   P N   +    +  P 
Sbjct: 702 RRKLDQVES-----GSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNF-PQ 755

Query: 575 VKK-----RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 626
           V K     R   L +    K++  +F+ +  +  +    E+ R++ + +++++ +E+
Sbjct: 756 VDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLV----EEIRKKTKIIQSYILREE 808



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 89/461 (19%), Positives = 183/461 (39%), Gaps = 68/461 (14%)

Query: 34  EFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREK 93
           E  RLI   D+ + +++   V+ V    + + A+   H+   + L++   +L    E   
Sbjct: 370 ETTRLIREIDK-LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 428

Query: 94  ALRKHAEEKFIEFEDSQEQEKKDLQTRVE----SLESQTRQLELKAKNYADQISRLEERE 149
            +RK+ ++    +++S+E +  +L  ++      LE Q ++   + + +  +I  LE+ +
Sbjct: 429 QIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLK 488

Query: 150 AELKKEYNALHQRHTEM-------------IHNYMEHLERTK------LHQLSGSDQLES 190
              K+  + L    T++             +  Y E + R K      L ++  +DQL+ 
Sbjct: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQE 548

Query: 191 TAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDEL 250
                 ++   +   +  L +    L  D QK  +  GS + + + L      TS   +L
Sbjct: 549 QLQRGKQEIENLKEEVESLNS----LINDLQK--DIEGSRKRESELLLFTERLTSKNAQL 602

Query: 251 SDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQ- 309
              S          S + S +      +  ++  +  + +     K E  +  EVQ  Q 
Sbjct: 603 QSESNSLQSQFDKVSCSESQL-----QSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA 657

Query: 310 -------ETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFD 362
                  E + +ST   E +++   Q    ++   D+ K L   + +      +E+ ++D
Sbjct: 658 ELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL---QQARRKLDQVESGSYD 714

Query: 363 RNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIA 422
           +   S+    SS+GS            L      E+   ENT         + V  D   
Sbjct: 715 KEVSSMGSRSSSSGS------------LNARSSAEDRSPENTG--------SSVAVDNFP 754

Query: 423 KVDE-LTCEKDVLQGELEAVKQAKLK-LEEKNRELEEELRK 461
           +VD+ +  E+ V   +  A K  K++ +E+  ++L EE+RK
Sbjct: 755 QVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRK 795



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 54/265 (20%), Positives = 108/265 (40%), Gaps = 29/265 (10%)

Query: 395 EVENLILENTQLLET-KNALNIVKNDLIAKVDELTCEKDVLQGELEAVK-QAKLKLEEKN 452
           E +NL  E  +  ET K  +N +K  L ++++EL  E    + +L A    AK  +++ +
Sbjct: 229 EKDNLREELKKRTETEKQHMNTIKQ-LESRIEELNKEVKASRDQLIAQDVTAKNAVQQLH 287

Query: 453 RELEEELRKARAEAEDARQKAK---------DDDDSDIPTAQRKRFTRVEMARVLMERN- 502
           +E+ + + +A  + E+ARQ+ +         + +  D+   +     ++  A   +E+N 
Sbjct: 288 KEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNT 347

Query: 503 -------QYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSI----W---QFFSRLFSS 548
                  Q K RL +L E  +  E  R  RE   ++E   S +    W   +  + + S 
Sbjct: 348 NKIKQLSQEKGRLHQLYE-TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH 406

Query: 549 SSNTTKKPEPPVNL-KYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASR 607
                K  E    L +       +  + +    T  +    KS   D     T+  L  +
Sbjct: 407 KETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQ 466

Query: 608 REQKREQYRQVKAHVQKEDGRVQAF 632
            ++K +Q     A +++ +   + F
Sbjct: 467 MQEKSDQLEMHHAKIKELEDLKRTF 491


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 120/538 (22%), Positives = 217/538 (40%), Gaps = 72/538 (13%)

Query: 2    ELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDE---EVVKELMPLVVAVL 58
            +LE+ +  +E+          ++ G    +  +   L  + DE   ++ K+   L  A+ 
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
               D    ++   +V  EL     E L   +E EKA R  AE++  +  +  E  K +L+
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAE-LQEDFESEKASRNKAEKQKRDLSEELEALKTELE 1156

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
               ++L++   Q EL+ K         E+  AELKK      + H   I + M     T 
Sbjct: 1157 ---DTLDTTAAQQELRTKR--------EQEVAELKKALEEETKNHEAQIQD-MRQRHATA 1204

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ-EL 237
            L +L  S+QLE     +   E+             GL T + +   E    +Q K + E 
Sbjct: 1205 LEEL--SEQLEQAKRFKANLEK----------NKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 238  SQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE--GFVKVTDAPN 295
             + +    +++  + VS+G       A  A+     +   + L EE E  G     DA +
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312

Query: 296  KSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPEL--DMDKDLSGYKGS 349
                 +  +  + +ETR   N+S+   +  EEK+ +Q   E   E   +++K +   +  
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372

Query: 350  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLET 409
               TK    K  D +  ++ E L  A   L+ D +       + + +E   L   +L +T
Sbjct: 1373 LADTK----KKVDDDLGTI-ESLEEAKKKLLKDAE------ALSQRLEEKALAYDKLEKT 1421

Query: 410  KNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDA 469
            KN L         ++D+LT        +L+  +Q    LE+K ++ ++ L    AE +  
Sbjct: 1422 KNRLQ-------QELDDLTV-------DLDHQRQVASNLEKKQKKFDQLL----AEEKSI 1463

Query: 470  RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREN 527
              +  ++ D     A+ K    + +AR L E  + KE      E  R  + +RA  E+
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKE------EFERQNKQLRADMED 1515



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 146/799 (18%), Positives = 311/799 (38%), Gaps = 149/799 (18%)

Query: 20   MSERVSGLAGSIYREFERLIGRYDE-EVVKELMPLVVAVLENLDSVFA-------QDQEH 71
            ++++   L G++ R  +  + + +  +VV+EL   +  + E+ +S  A       Q ++ 
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144

Query: 72   QVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQL 131
              ELE L+ + E  +     ++ LR   E++  E + + E+E K+ + +++ +    RQ 
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM----RQR 1200

Query: 132  ELKA-KNYADQISRLEEREAELKKEYNALHQRHTEMIHNY--MEHLERTKLHQLSGSDQL 188
               A +  ++Q+ + +  +A L+K    L   + E+      ++ ++    H+    D  
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260

Query: 189  ESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGS--------EQWKFQELSQP 240
                H+++ +             GD L    A+K  +            E+ + + +   
Sbjct: 1261 VQELHAKVSE-------------GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307

Query: 241  RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTD-TPLKEENEGFVKVTDAPNKSEI 299
            +   SL+ +L D  +   + T      +S +  +  +   L+E+ E          + E 
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE---------EEEEA 1358

Query: 300  SKHIEVQV-AQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN 358
             K++E QV A +++   T    +++   ++++ E+  +L  D +    +      K +  
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR---LEEKALAY 1415

Query: 359  KAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL------------ 406
               ++    L +EL      L       ++L    ++ + L+ E   +            
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 407  --------------------LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKL 446
                                LE K         L A +++L   KD +   +        
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH------- 1528

Query: 447  KLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKE 506
            +LE+  R LE+++ + R + E+   + +  +D+ +      +  + +  R L  R++  E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588

Query: 507  RLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 566
                L        +I+  RE  A  E +R        R  + +S    K +  ++LK   
Sbjct: 1589 EKKRL--------LIKQVRELEAELEDERK------QRALAVAS----KKKMEIDLK--D 1628

Query: 567  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRRE---QKREQYRQVKA--- 620
              + +  + K R   + QL   +++  D+   E E + ASR E   Q +E  +++K+   
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDY-QRELEEARASRDEIFAQSKESEKKLKSLEA 1687

Query: 621  ---HVQKEDGRVQAFGWSLPQK----YKQVTNGQG-------ENKMKNLPVPVYLRPLDE 666
                +Q+E    +       Q+      ++TN          E +     +      L+E
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747

Query: 667  KDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQE 726
            + ++M+L     +N    KT               V  L+ E + +RSA+Q S D   Q+
Sbjct: 1748 EQSNMEL-----LNDRFRKTT------------LQVDTLNAELAAERSAAQKS-DNARQQ 1789

Query: 727  LKEQQKELKNQ-EELSSLV 744
            L+ Q KELK + +EL   V
Sbjct: 1790 LERQNKELKAKLQELEGAV 1808



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 148/741 (19%), Positives = 288/741 (38%), Gaps = 117/741 (15%)

Query: 56   AVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKK 115
            A +++L+    +++  + +L+L +   E  I + E E  L +    KFI+       EKK
Sbjct: 950  AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK-------EKK 1002

Query: 116  DLQTRVESLESQTRQLELKAKNYAD-------QISRLEER-------EAELKKEYNALHQ 161
             ++ R+    SQ  + E KAKN A         IS LEER         EL+K    L  
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062

Query: 162  RHTEM---IHNYMEHLERTKLHQLSGSDQLESTA----HSRIRKERPISLGIFPLPAGDG 214
              T++   I      ++  KL      ++L+          + K   + + +  L A   
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIA 1121

Query: 215  LLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATI 274
             L  D +    +    + + ++LS+     +LK EL D     +      +    +VA +
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELE--ALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 275  PTDTPLKEENEGF-VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEE--KSEVQAII 331
                 L+EE +    ++ D   +   +     +  ++ +       +N++  +++ + + 
Sbjct: 1180 --KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237

Query: 332  ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG 391
                 L   K  S +K      +  E  A     + L  EL+   S L  ++D  + LL 
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297

Query: 392  MGRE-----------VENLILENTQLL--ETKNALNIVKNDLIAKVDELTCEKDVLQGEL 438
               +           +E+ + +  +LL  ET+  LN     L +++ +L  EK+ LQ + 
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-----LSSRIRQLEEEKNSLQEQQ 1352

Query: 439  EAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVL 498
            E  ++A+  LE++   L+ +L   +        K  DDD   I + +  +   ++ A  L
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTK--------KKVDDDLGTIESLEEAKKKLLKDAEAL 1404

Query: 499  MER-----------NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFS 547
             +R            + K RL   QE    T  +   R+  +  EKK+    Q  +    
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQ--QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE--- 1459

Query: 548  SSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASR 607
                     E  ++ +Y           ++R    ++    ++KA   L+   E +L ++
Sbjct: 1460 ---------EKSISARY----------AEERDRAEAEAREKETKALS-LARALEEALEAK 1499

Query: 608  REQKREQYRQVKAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLPVPVYLRPLD 665
             E +R Q +Q++A ++         G ++   +K K+    Q E     L         D
Sbjct: 1500 EEFER-QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE-----ELED 1553

Query: 666  EKDTSMKLWCAVGVNLSGGK--------TRDGGSVVGASVFYKDVAGLDTE---GSKQRS 714
            E   +      + VN+   K        TRD  +     +  K V  L+ E     KQR+
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613

Query: 715  ASQSSLDKLDQELKEQQKELK 735
             + +S  K++ +LK+ + +++
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIE 1634



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 131/649 (20%), Positives = 251/649 (38%), Gaps = 170/649 (26%)

Query: 56   AVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKK 115
            A ++ L +  ++    +VEL    +   +L  + +    L + AE+K I+F       + 
Sbjct: 1259 AQVQELHAKVSEGDRLRVELA---EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 116  DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
             LQ   E L+ +TRQ      N + +I +LEE       E N+L ++  E      ++LE
Sbjct: 1316 QLQDTQELLQEETRQ----KLNLSSRIRQLEE-------EKNSLQEQQEEE-EEARKNLE 1363

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLG-IFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
            +  L   S   QL  T     +K+    LG I  L      L  DA+   +    +   +
Sbjct: 1364 KQVLALQS---QLADT-----KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 235  QELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAP 294
             +L + ++   L+ EL D++                                     D  
Sbjct: 1416 DKLEKTKNR--LQQELDDLT------------------------------------VDLD 1437

Query: 295  NKSEISKHIEV------QVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKG 348
            ++ +++ ++E       Q+  E +++S   AE  +++E +A  + T  L + + L     
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE---- 1493

Query: 349  SSTPTKGIENKA-FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLL 407
                 + +E K  F+R  + L  ++      L+   D+      +G+ V        +L 
Sbjct: 1494 -----EALEAKEEFERQNKQLRADMED----LMSSKDD------VGKNVH-------ELE 1531

Query: 408  ETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKL------------------- 448
            ++K AL         +V+E+  + + L+ EL+A + AKL+L                   
Sbjct: 1532 KSKRALE-------QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584

Query: 449  ---EEKNRELEEELRKARAEAEDARQKAK-------------DDDDSDIPTAQRKRFTRV 492
               EEK R L +++R+  AE ED R++                D ++ I  A + R   +
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI 1644

Query: 493  EMARVLMERNQYKERLMELQEA-VRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSS--- 548
            +  R L  + Q K+   EL+EA     E+   S+E+    +   + I Q    L SS   
Sbjct: 1645 KQLRKL--QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702

Query: 549  ----------------SSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKA 592
                            +S + K        +  A  + +   +++  S + +L  D+ + 
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM-ELLNDRFRK 1761

Query: 593  FDFLSEETEASLASR----------REQKREQYRQVKAHVQKEDGRVQA 631
                 +   A LA+           R+Q   Q +++KA +Q+ +G V++
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 130/639 (20%), Positives = 248/639 (38%), Gaps = 80/639 (12%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            + R+ E L  + DEE++K        V E    V  + +E + + + L ++   L  Q +
Sbjct: 847  VTRQEEELQAK-DEELLK--------VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897

Query: 91   REKALRKHAEE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
             E  L   AEE   +    +   E+   DL++RVE  E + + L+ + K     I  LEE
Sbjct: 898  AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 148  R--EAELKKEYNALHQRHTEMIHNYMEH----LERTKLHQLSGSDQLE---STAHSRIRK 198
            +  E E  ++   L +   E     ME     LE      +     +E   +   S++ +
Sbjct: 958  QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017

Query: 199  ERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPR-----SHTSLKDELSDV 253
            E   +  +  +     ++  D +   E    E+   QEL + +       T L+D+++++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLE---ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074

Query: 254  SQ---------GGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIE 304
                          +     + A  D  T+  +  LK   E   ++ +     E  K   
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134

Query: 305  VQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN 364
             +  ++ R++S      EE   ++  +E T  LD        +           KA +  
Sbjct: 1135 NKAEKQKRDLS------EELEALKTELEDT--LDTTAAQQELRTKREQEVAELKKALEEE 1186

Query: 365  TESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV 424
            T++   ++          ++E ++ L   +  +  + +N Q LET N             
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN------------- 1233

Query: 425  DELTCEKDVLQGELEAVKQAKLKLEEKNRELE------EELRKARAEAEDARQKAKDDDD 478
             EL CE  VLQ      +  + KL+ + +EL       + LR   AE     Q   D+  
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293

Query: 479  SDIPTAQRKRFTRVEMARVLMERNQYKERLME--------LQEAVRWTEMIRAS-RENPA 529
            + +  A++K     + A  L  + Q  + L++        L   +R  E  + S +E   
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353

Query: 530  MQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDK 589
             +E+ R ++ +    L S  ++T KK +   +L            + K +  LSQ   +K
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDD--DLGTIESLEEAKKKLLKDAEALSQRLEEK 1411

Query: 590  SKAFDFLSEETEASLASRREQ---KREQYRQVKAHVQKE 625
            + A+D L E+T+  L    +      +  RQV ++++K+
Sbjct: 1412 ALAYDKL-EKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 29/178 (16%)

Query: 44   EEVVKELMPLVVAVLE----------NLDSVFAQDQEHQVELELLRDDNEQLITQYEREK 93
            +EV+K+L  L   + +          + D +FAQ +E + +L+ L  +  QL  +    +
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700

Query: 94   ALRKHAEEKFIEFED----------SQEQEKKDLQTRV----ESLESQTRQLELKAKNYA 139
              R+HAE++  E  D          +   EK+ L+ R+    E LE +   +EL    + 
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760

Query: 140  DQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIR 197
                +++   AEL  E +A      +   N  + LER      +   +LE    S+ +
Sbjct: 1761 KTTLQVDTLNAELAAERSA-----AQKSDNARQQLERQNKELKAKLQELEGAVKSKFK 1813



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 62/296 (20%), Positives = 115/296 (38%), Gaps = 65/296 (21%)

Query: 340  DKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENL 399
            D++L   K   T  +G E +  +R  + L EE +     L  + +  A+   M       
Sbjct: 858  DEELLKVKEKQTKVEG-ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM------- 909

Query: 400  ILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEEL 459
                 +L   K  L  + +DL ++V+E      +LQ E       K K++   ++LEE+L
Sbjct: 910  ---RARLAAKKQELEEILHDLESRVEEEEERNQILQNE-------KKKMQAHIQDLEEQL 959

Query: 460  RKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTE 519
                 E E ARQK +                        +E+   + ++ +++E +    
Sbjct: 960  ----DEEEGARQKLQ------------------------LEKVTAEAKIKKMEEEI---- 987

Query: 520  MIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNL-----KYNAPTSHVTPS 574
            ++   + +  ++EKK         R+   SS   ++ E   NL     K     S +   
Sbjct: 988  LLLEDQNSKFIKEKKLME-----DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042

Query: 575  VKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
            +KK   T  +L   K K    L  ET   L  +  + + Q  ++K  + K++  +Q
Sbjct: 1043 LKKEEKTRQELEKAKRK----LDGET-TDLQDQIAELQAQIDELKLQLAKKEEELQ 1093



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 85/444 (19%), Positives = 171/444 (38%), Gaps = 90/444 (20%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE+  EL     A L    ++ A   + + +L+   + NE      E+++ L K   E  
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE------EKKRLLIKQVRELE 1602

Query: 104  IEFEDSQEQE------KKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYN 157
             E ED ++Q       KK ++  ++ LE+Q   +E   K   + I +L + +A++K    
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQ---IEAANKARDEVIKQLRKLQAQMK---- 1655

Query: 158  ALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLT 217
                       +Y   LE  +    +  D++ + +    +K + +   I  L        
Sbjct: 1656 -----------DYQRELEEAR----ASRDEIFAQSKESEKKLKSLEAEILQLQE------ 1694

Query: 218  PDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTD 277
                   E   SE+ + +   Q R    L DE+++ + G S          + +A +  +
Sbjct: 1695 -------ELASSERAR-RHAEQERDE--LADEITNSASGKSALLDEKRRLEARIAQLEEE 1744

Query: 278  TPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAE-NEEKSEVQAIIESTPE 336
              L+EE      + D   K+             T  V T +AE   E+S  Q    +  +
Sbjct: 1745 --LEEEQSNMELLNDRFRKT-------------TLQVDTLNAELAAERSAAQKSDNARQQ 1789

Query: 337  LD-MDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGRE 395
            L+  +K+L             + +  +   +S F+   SA    IG ++E  +     R 
Sbjct: 1790 LERQNKELKA-----------KLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838

Query: 396  VENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 455
              N ++  T+             ++  +V++     D  + ++E   +A  ++++  R+L
Sbjct: 1839 AANKLVRRTEKK---------LKEIFMQVEDERRHADQYKEQME---KANARMKQLKRQL 1886

Query: 456  EEELRKARAEAEDARQKAKDDDDS 479
            EE   +A       R+  ++ DD+
Sbjct: 1887 EEAEEEATRANASRRKLQRELDDA 1910


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 145/730 (19%), Positives = 274/730 (37%), Gaps = 117/730 (16%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVES-----L 124
            E + E+  +++D E+   +  R +A RK  EEK +    S  QEK DLQ +V+S     +
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRKELEEKMV----SLLQEKNDLQLQVQSETENLM 903

Query: 125  ESQTR---------QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            +++ R          LE K K   +++   EE  +EL  +   L  + + +  + ++ LE
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD-IDDLE 962

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             T         ++E   H+   K + +S  +  L      LT + +   E   + Q    
Sbjct: 963  LT-------LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE---AHQQTLD 1012

Query: 236  ELSQP--------RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGF 287
            +L           + +  L+ +  D+   GS        A+ + A    +  LK   E  
Sbjct: 1013 DLQVEEDKVNGLIKINAKLEQQTDDLE--GSLEQEKKLRADLERAKRKLEGDLKMSQESI 1070

Query: 288  VKV-TDAPNKSEISKHIEVQVAQETRNVSTGSAEN----EEKSEVQAIIESTPELDMDKD 342
            + +  D     E  K  E +++Q    +      +    ++  E+QA IE   E      
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE------ 1124

Query: 343  LSGYKGSSTPTKGIENKAFD--RNTESLFEELSSAGSGLIGDVD----EGADLLGMGREV 396
                +   T    IE +  D  R  E + E L  A       ++      A+   M R++
Sbjct: 1125 --EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL 1182

Query: 397  ENLILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 441
            E   L++                +L E  + L  VK  L  +  EL  E D +   +EA+
Sbjct: 1183 EEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242

Query: 442  KQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMER 501
             ++K  +E   R +E++  + +A+ E   Q   D                ++ AR+  + 
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHD--------------LNMQKARLQTQN 1288

Query: 502  NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 561
             +   R+ E +  +             +   K + ++ Q    L       TK      +
Sbjct: 1289 GELSHRVEEKESLI-------------SQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335

Query: 562  LKYNA--PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSE---ETEASLASRREQKREQYR 616
               ++      +    ++     ++L    SKA   +++   + E     R E+  E  +
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395

Query: 617  QVKAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLP-VPVYLRPLDEKDTSMKL 673
            ++   +Q+ +   +         +K KQ   G+ E+ M++L         LD+K  +   
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF-- 1453

Query: 674  WCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKE 733
                   L+  K +   S        K+   L TE  K R+A +  +D+L + L+ + K 
Sbjct: 1454 ----DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL-ETLRRENKN 1508

Query: 734  LKNQEELSSL 743
            L  QEE+S L
Sbjct: 1509 L--QEEISDL 1516



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 155/747 (20%), Positives = 287/747 (38%), Gaps = 131/747 (17%)

Query: 58   LENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKA----LRKHAEEKFIEFEDSQEQE 113
            ++NL  V  + ++ + EL++  DD    I    + K+      +  E++F E +   EQ+
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270

Query: 114  ----------KKDLQT-------RVESLESQTRQLELKAKNYADQISRLEEREAELKKEY 156
                      K  LQT       RVE  ES   QL  K+K    Q  +LEE + ++++E 
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL-TKSKQALTQ--QLEELKRQMEEET 1327

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLS-GSDQLESTAHSRIRKERPISLGIFPLPAGDGL 215
             A          N M H  ++  H      +Q E    ++   +R +S            
Sbjct: 1328 KA---------KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALS------------ 1366

Query: 216  LTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIP 275
                  K        + K++  +  R+   L++    ++Q   +A     TANS  A++ 
Sbjct: 1367 ------KANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQEAEENTETANSKCASL- 1418

Query: 276  TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEK-SEVQAIIEST 334
                 K+  +G  +V D     E S      + ++ RN     AE ++K  E QA +E+ 
Sbjct: 1419 --EKTKQRLQG--EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474

Query: 335  PE------LDMDKDLSGYKG--SSTPTKGIENKAFDRNTESLFEELSSAGSGLIGD---- 382
             +       ++ K  + Y+       T   ENK        L E+++  G  L       
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534

Query: 383  ---VDEGADLLGMGREVE-NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGEL 438
                 E +DL     EVE +L  E +++L  +  L+ VK++L  KV     EKD    E+
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV----IEKD---EEI 1587

Query: 439  EAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDD-DDSDIPTAQRKRFTRVEMARV 497
            E +K+   +  E  + + +   ++R +A   ++K + D ++ +I      R        +
Sbjct: 1588 EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647

Query: 498  LMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPE 557
               + Q K+  + L +A+R  E +   +E  A+ E++   + +             +  E
Sbjct: 1648 RTVQGQLKDSQLHLDDALRSNEDL---KEQLAIVERRNGLLLE-------------ELEE 1691

Query: 558  PPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQ 617
              V L+    T  ++      +S   QL   ++ +     ++ EA +A  + +     ++
Sbjct: 1692 MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751

Query: 618  VK-AHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCA 676
             + A  + +     A   +   K +Q T+   E   KNL   V       KD   +L  A
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV-------KDLQHRLDEA 1804

Query: 677  VGVNLSGGK---------------------TRDGGSVVGASVFYKDVAGLD---TEGSKQ 712
              + L GGK                      R   ++ GA  + + V  +     E  K 
Sbjct: 1805 EQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKN 1864

Query: 713  RSASQSSLDKLDQELKEQQKELKNQEE 739
                Q  +DKL  ++K  +++ +  EE
Sbjct: 1865 ILRLQDLVDKLQAKVKSYKRQAEEAEE 1891



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 89/451 (19%), Positives = 185/451 (41%), Gaps = 54/451 (11%)

Query: 45   EVVKELMPLVVAVLENLDSVFAQDQEHQ------VELELLRDDNEQLITQYEREKALRKH 98
            ++ KE   L  A  + LD +  ++ +         +LE   DD E  + Q ++ +A  + 
Sbjct: 995  KLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054

Query: 99   AEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNA 158
            A+ K        E + K  Q  +  LE+  +Q+E K K    ++S+L   +A++  E   
Sbjct: 1055 AKRKL-------EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL---QAKIDDE--- 1101

Query: 159  LHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKER-PISLGIFPLPAGDGLLT 217
              Q H+      ++ L+  ++ +L    + E T  ++I K+R  ++  +  +       +
Sbjct: 1102 --QVHSLQFQKKIKELQ-ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS 1158

Query: 218  PDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANS-DVATIPT 276
                   E     + +FQ++ +     +L+ E +  +    +A + A      D      
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218

Query: 277  DTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPE 336
                KE++E  +++ D  +  E     +  + +  R V    +E + K E Q   +   +
Sbjct: 1219 QKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQT--QLIHD 1276

Query: 337  LDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREV 396
            L+M K       +   T+  E        ESL  +L+ +   L   ++E      + R++
Sbjct: 1277 LNMQK-------ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE------LKRQM 1323

Query: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE 456
            E          ETK      KN +   +     + D+L+ + E  ++AK +L+    +  
Sbjct: 1324 EE---------ETK-----AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369

Query: 457  EELRKARAEAE-DARQKAKDDDDSDIPTAQR 486
             E+ + R + E DA Q+ ++ +++    AQR
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 85/442 (19%), Positives = 167/442 (37%), Gaps = 50/442 (11%)

Query: 48   KELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFE 107
            K L   +  + E +       QE +   +L+  +   L    E  +   +H E K +  +
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566

Query: 108  DSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAE-------LKKEYNA-L 159
                Q K +L  +V   + +  QL+  ++  A+ +  + + E         LKK+    L
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

Query: 160  HQRHTEMIHNYMEHLERTKLHQLSGSDQL-ESTAH--SRIRKERPISLGIFPLPAGDGLL 216
            ++   ++ H+  +  E T+ H  +   QL +S  H    +R    +   +  +   +GLL
Sbjct: 1627 NEMEIQLGHSNRQMAE-TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685

Query: 217  TPDAQKGG----ETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVA 272
              + ++      +T  + +   QEL        L     + S   +K    A  A     
Sbjct: 1686 LEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS-QNTSLINTKKKLEADIAQCQAE 1744

Query: 273  TIPTDTPLKEENEGFVK-VTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAII 331
               +    +   E   K +TDA   +E     E++  Q+T    +   E  +K+  Q + 
Sbjct: 1745 VENSIQESRNAEEKAKKAITDAAMMAE-----ELKKEQDT----SAHLERMKKNLEQTVK 1795

Query: 332  ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG 391
            +    LD  + L+  KG     + +EN+  +   E   E+              GA+ L 
Sbjct: 1796 DLQHRLDEAEQLA-LKGGKKQIQKLENRVRELENELDVEQ------------KRGAEALK 1842

Query: 392  MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEK 451
               + E  + E T   E  +   +   DL+          D LQ ++++ K+   + EE+
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLV----------DKLQAKVKSYKRQAEEAEEQ 1892

Query: 452  NRELEEELRKARAEAEDARQKA 473
                    R+ + E E+A ++A
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERA 1914


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 80/375 (21%), Positives = 159/375 (42%), Gaps = 55/375 (14%)

Query: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE 456
            + L ++N  L ET    N++    + +  ++  ++ +  GELE     + KLE++  +LE
Sbjct: 888  KELKIKNHSLQETSEQ-NVILQHTLQQQQQMLQQETIRNGELE---DTQTKLEKQVSKLE 943

Query: 457  EELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMA----RVLMERNQYKERLMELQ 512
            +EL+K R  + +  +K ++  +S    A  KR   +E+     +V +E +QYKE L +++
Sbjct: 944  QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003

Query: 513  EAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVT 572
            + +     ++   EN AM   +   I           +N  K+ E    L+++  T  +T
Sbjct: 1004 KEIM---HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELE---KLQHSTET-ELT 1056

Query: 573  PSVKKR--------------SSTLSQLPGDK---SKAFDFLSEE--TEASLASRREQKRE 613
             +++KR               STL QL   +    KA   L E+  T   L +   + + 
Sbjct: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM 1116

Query: 614  QYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTN---------GQGENKMKNLPVPVYLRPL 664
            +    K  + + D  ++   W L Q+  QVT+         G+ E K+  L   +    L
Sbjct: 1117 EIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSEL 1176

Query: 665  DEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLD 724
            + K+      C   +     K ++    +    F      +  +  ++ S  +  +++  
Sbjct: 1177 ELKE------CNKQIESLNDKLQNAKEQLREKEF------IMLQNEQEISQLKKEIERTQ 1224

Query: 725  QELKEQQKELKNQEE 739
            Q +KE +  +K QE+
Sbjct: 1225 QRMKEMESVMKEQEQ 1239



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 137/685 (20%), Positives = 277/685 (40%), Gaps = 86/685 (12%)

Query: 79  RDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNY 138
           R  NE L    E  KA +++ ++K  E  +  + E++ L+  + + E + ++L+ +   Y
Sbjct: 354 RQRNEALYNAEELSKAFQQY-KKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLY 412

Query: 139 ADQISRLEEREAELKKEYN-------ALHQRHTEMIHNYMEHLERT-KLH-QLSGSDQLE 189
             ++  L+E+  +LK+E N        +  +++E++    E  +   KL  +L   D++ 
Sbjct: 413 KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL 472

Query: 190 STAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDE 249
               S + + R + + +        L   + +       S + + + L +  S   LK E
Sbjct: 473 RDKFSLMNENRELKVRVAAQNERLDLCQQEIE-------SSRVELRSLEKIISQLPLKRE 525

Query: 250 LSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISK-HIEVQVA 308
           L       SK    + +   D      +      +E  +K+  A  ++EI K H  +   
Sbjct: 526 LFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKL--AIKEAEIQKLHANLTAN 583

Query: 309 QETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESL 368
           Q ++++ T + +++E S++ ++     +L   +     K  +  T    NK +++  + L
Sbjct: 584 QLSQSLITCN-DSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTM---NKQYEKERQRL 639

Query: 369 FEELSSAGSGLIGDVDEGADL-LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDEL 427
              +    + LI    E +DL + M        L   +LLE  +  + +++++  K  +L
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQL 699

Query: 428 TCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK 487
                 L+ +LE    A   +  KN ELE+EL +   +            +++I T   K
Sbjct: 700 L----TLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL--------ETNINTEHEK 747

Query: 488 RFTRVEMA-RVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ------ 540
                E A ++ +E+++  E+ +E  EA      +    +    QEK  S + Q      
Sbjct: 748 ICLAFEKAKKIHLEQHKEMEKQIERLEA-----QLEKKDQQFKEQEKTMSMLQQDIICKQ 802

Query: 541 ----FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 596
                  RL + S    KK     N+K +     +   V + +  + QL      A +  
Sbjct: 803 HHLESLDRLLTESKGEMKKE----NMKKDEALKALQNQVSEETIKVRQL----DSALEIC 854

Query: 597 SEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLP 656
            EE                  +  H+ + +G  + F   L +K ++V   Q E K+KN  
Sbjct: 855 KEE------------------LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896

Query: 657 VPVYLRPLDEKDTSMKLWCAVGVNLSGGKT-RDGGSVVGASVFYKDVAGLDTEGSKQRSA 715
               L+   E++  ++        +   +T R+G      +   K V+ L+ E  KQR +
Sbjct: 897 ----LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 952

Query: 716 SQSSLDKLDQ--ELKEQQKELKNQE 738
           S   L K+++  E    + +LK Q+
Sbjct: 953 SAEKLRKMEEKCESAAHEADLKRQK 977



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 111/512 (21%), Positives = 210/512 (41%), Gaps = 71/512 (13%)

Query: 58   LENLDSVFAQDQEHQVELELLRDDNEQLITQYERE-KALRKHAEEKFIEFEDSQEQ--EK 114
            L+    +  Q+     ELE  +   E+ +++ E+E +  R+ + EK  + E+  E    +
Sbjct: 911  LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 970

Query: 115  KDLQT-RVESLESQTRQLELKAKNYADQISRLEEREAELKK--EYNALHQRHTEMIHNYM 171
             DL+  +V  L    RQ++++   Y +++S++E+    LK+  E  A+H    +MI    
Sbjct: 971  ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI---- 1026

Query: 172  EHLERTKLH---QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPG 228
              L++TK     + +   +LE   HS                  +  LT   QK      
Sbjct: 1027 --LDQTKTELEKKTNAVKELEKLQHST-----------------ETELTEALQKREVLET 1067

Query: 229  SEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFV 288
              Q    EL   +S      EL DV Q    +     T   D+          E  E  +
Sbjct: 1068 ELQNAHGEL---KSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA--------ELRECKM 1116

Query: 289  KVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKG 348
            ++ D   K E+   +E+  A + RN        +       I E   E  M++ +   +G
Sbjct: 1117 EIED--KKQEL---LEMDQALKERNWELKQRAAQVTHLDMTIREHRGE--MEQKIIKLEG 1169

Query: 349  SSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENL--ILENTQ- 405
            +   ++ +E K  ++  ESL ++L +A   L    ++   +L   +E+  L   +E TQ 
Sbjct: 1170 TLEKSE-LELKECNKQIESLNDKLQNAKEQL---REKEFIMLQNEQEISQLKKEIERTQQ 1225

Query: 406  -LLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNR---ELEEELRK 461
             + E ++ +   +  +  +  E       L+   E V+ +  +L E      + + E+ +
Sbjct: 1226 RMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIER 1285

Query: 462  ARAEAEDARQKAKDDDDSDIPTAQRKRFTRVE----MARVLMERNQYKERLMELQEAVRW 517
              +E ED +Q +K+ D      A+    ++V      AR+  E  +    +  L+EA   
Sbjct: 1286 LSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYH- 1344

Query: 518  TEMIRASRENPA----MQEKKRSSIWQFFSRL 545
             EMI + +EN A      + ++SS+ Q   +L
Sbjct: 1345 MEMI-SHQENHAKWKISADSQKSSVQQLNEQL 1375



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 109/503 (21%), Positives = 193/503 (38%), Gaps = 81/503 (16%)

Query: 58   LENLDSVFAQDQEHQVELELLRDD---------NEQLITQYEREKALRKHAEEKFIEFED 108
            LE+LD +  + +    +  + +D+         +E+ I   + + AL    EE  +    
Sbjct: 805  LESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ 864

Query: 109  SQ-EQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMI 167
             +  +EK + Q + +S E    Q ELK KN++     L+E       E N + Q HT   
Sbjct: 865  LEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS-----LQE-----TSEQNVILQ-HTLQQ 913

Query: 168  HNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETP 227
               M   E  +      + +LE T   + + E+ +S            L  + QK  E+ 
Sbjct: 914  QQQMLQQETIR------NGELEDT---QTKLEKQVS-----------KLEQELQKQRESS 953

Query: 228  GSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGF 287
              +  K +E  +  +H     E     Q   + T  A     ++     +   K E E  
Sbjct: 954  AEKLRKMEEKCESAAH-----EADLKRQKVIELTGTARQVKIEMDQYKEELS-KMEKEIM 1007

Query: 288  VKVTDAPNKSEISKHIEVQVAQETRNV--STGSAENEEKSEVQAIIESTPELD----MDK 341
                D  NK+     +++ + Q    +   T + +  EK +     E T  L     ++ 
Sbjct: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLET 1067

Query: 342  DLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLIL 401
            +L    G        E K+  R  + L + L  A   L        DL    RE +  I 
Sbjct: 1068 ELQNAHG--------ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE 1119

Query: 402  ENTQ-LLETKNAL---NIVKNDLIAKVDELTCEKDVLQGELE--------AVKQAKLKLE 449
            +  Q LLE   AL   N       A+V  L       +GE+E         +++++L+L+
Sbjct: 1120 DKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELK 1179

Query: 450  EKNRELEEELRKARAEAEDARQK-----AKDDDDSDI-PTAQRKRFTRVEMARVLMERNQ 503
            E N+++E    K +   E  R+K       + + S +    +R +    EM  V+ E+ Q
Sbjct: 1180 ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239

Query: 504  YKERLMELQEAVRWTEMIRASRE 526
            Y     + +EA+   + +R +RE
Sbjct: 1240 Y--IATQYKEAIDLGQELRLTRE 1260


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 103/503 (20%), Positives = 198/503 (39%), Gaps = 64/503 (12%)

Query: 57   VLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEE--KFIEFEDSQEQEK 114
            V++N  S     +E  ++L+ LR  + +  ++ ++ +   + AE+  K +E E + E  K
Sbjct: 712  VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771

Query: 115  KDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL 174
                TR    E Q R  ELK  N  + +S + + +  L+KE   L ++  E         
Sbjct: 772  ASSITR----ELQGR--ELKLTNLQENLSEVSQVKETLEKELQILKEKFAE--------- 816

Query: 175  ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
                   +S    ++ T +   +KE   +           +L+ D +K  E     + KF
Sbjct: 817  --ASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEKLRENLADMEAKF 863

Query: 235  QELSQP-----RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVK 289
            +E  +      ++   L+++++++ +     ++  +  N ++     D       E  +K
Sbjct: 864  REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-----EELQLK 918

Query: 290  VTDA-PNKSEISKHIE-VQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYK 347
            +T A  N S + K IE + V  E           EEK E++  +      D++K +    
Sbjct: 919  LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS-----DLEKKMETSH 973

Query: 348  GSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLL 407
                  K    +A         E L +    L+   D+   L G   E   L+ E  +L 
Sbjct: 974  NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK---LKGAREENSGLLQELEELR 1030

Query: 408  ETKNALNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE-------EKNRELEEE 458
            +  +     +   D +  ++++T EK      LE  KQ   KL+       E N +  EE
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090

Query: 459  LRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN-QYKERLMELQEAVRW 517
            L K++ E      +  ++   +I T ++    + +    L E N +  E L   ++ V  
Sbjct: 1091 LNKSK-ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1149

Query: 518  TEMIRASR---ENPAMQEKKRSS 537
             + +   R    N  ++ KKR S
Sbjct: 1150 HQKLEEERSVLNNQLLEMKKRES 1172



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 149/711 (20%), Positives = 278/711 (39%), Gaps = 113/711 (15%)

Query: 58   LENLDSVFAQDQE---HQVELELLRDDNEQLITQYERE-KALRKHAEEKFIEFEDSQEQE 113
            +ENL +   QD E   H  E+E LR    ++I + E   +A+R     K  + ED    E
Sbjct: 628  IENLQN--QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRS----KLDKAEDQHLVE 681

Query: 114  KKDLQTRVESLESQTRQLE-LKAK---------NYADQISRLEEREAELKKEYNALHQRH 163
             +D   +++  E + ++LE L+AK         N+  Q+   EE+  +L     A  +  
Sbjct: 682  MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741

Query: 164  TEM--IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ 221
            +EM  +   +E  E+ ++  L      ES+  S I +E         L   +  LT    
Sbjct: 742  SEMKKLRQQLEAAEK-QIKHLEIEKNAESSKASSITRE---------LQGRELKLT---- 787

Query: 222  KGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 281
                   + Q    E+SQ +   +L+ EL  + +  ++A+  A +    +         K
Sbjct: 788  -------NLQENLSEVSQVKE--TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838

Query: 282  EENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSE-VQAIIESTPELDMD 340
            EE    +        S++ K  E        N++   A+  EK E  + +I++  +L+ D
Sbjct: 839  EEQFNML-------SSDLEKLRE--------NLADMEAKFREKDEREEQLIKAKEKLEND 883

Query: 341  ----KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREV 396
                  +SG   S       E +  +R+ E L  +L+ A        +E A  L    E 
Sbjct: 884  IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA--------NENASFLQKSIED 935

Query: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVK----QAKLKLEEKN 452
              +  E +Q  E        K +L  K+ +L  + +    + + +K    +A  + + K+
Sbjct: 936  MTVKAEQSQ-QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 994

Query: 453  RELEEELRKARAEAEDARQKAKDDDDSDIPTAQ--RKRFTRVEMARVLMERNQYKERLME 510
             E+ + L+K   + ED  + A++++   +   +  RK+  + + A       Q  E  M+
Sbjct: 995  EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA-------QTAEDAMQ 1047

Query: 511  LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPT-- 568
            + E     +M +   E  A  E  + +  +  + L +   N  K  E  +N      T  
Sbjct: 1048 IME-----QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVE 1101

Query: 569  SHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGR 628
            +      +K   TL Q    KS+    L EE    LA    + R+   +V +H + E+ R
Sbjct: 1102 NQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRD---EVTSHQKLEEER 1157

Query: 629  VQAFGWSLPQKYKQ---VTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGK 685
                   L  K ++   + +   E       + +    L EKD  ++        L    
Sbjct: 1158 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE-------KLRNEV 1210

Query: 686  TRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKN 736
            T   G    A   +  V  L+++  K     +  +  L+ +LKE +++L +
Sbjct: 1211 TVLRGENASAKSLHSVVQTLESDKVK----LELKVKNLELQLKENKRQLSS 1257



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 82/414 (19%), Positives = 162/414 (39%), Gaps = 55/414 (13%)

Query: 74   ELELLRDDNEQLITQY----EREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTR 129
            EL L   D E+L  +     E    L+K  E+  ++ E SQ++  K  +   + LE +  
Sbjct: 904  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963

Query: 130  QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLE 189
             LE K +   +Q   L+ R      E      +H E++ N  + L  T+  +L G+ +  
Sbjct: 964  DLEKKMETSHNQCQELKARYERATSETKT---KHEEILQNLQKTLLDTE-DKLKGAREEN 1019

Query: 190  STAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDE 249
            S     + + R  +               D  K  +T        +++++ ++ T     
Sbjct: 1020 SGLLQELEELRKQA---------------DKAKAAQTAEDAMQIMEQMTKEKTETLAS-- 1062

Query: 250  LSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQ 309
            L D  Q  +K      T             LKE N   +K  +  NKS+    +E Q  +
Sbjct: 1063 LEDTKQTNAKLQNELDT-------------LKENN---LKNVEELNKSKELLTVENQKME 1106

Query: 310  ETRN-VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESL 368
            E R  + T      +KS+  + ++    + + ++L   +   T  + +E +    N + L
Sbjct: 1107 EFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1165

Query: 369  FEELSSAGSGLIGDVDEGADLLGMGREVENLIL--ENTQLLETKNALNIVKNDLIAKVDE 426
              E+    S  I D DE    L     + + +L  ++ +L + +N + +++ +       
Sbjct: 1166 --EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------- 1216

Query: 427  LTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD 480
                   L   ++ ++  K+KLE K + LE +L++ + +   +        D D
Sbjct: 1217 -NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADED 1269



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 132/693 (19%), Positives = 252/693 (36%), Gaps = 118/693 (17%)

Query: 70  EHQVELELLRDDNEQLITQYERE----KALRKHAEEKFIEFEDSQEQEKK---DLQTRVE 122
           E + EL L RD ++Q + + E +    + + + A+ + +E  +  E+EK+   DLQ RVE
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446

Query: 123 SLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQL 182
                   LE+   +   +I  LE+  A   +E   L +R           LE  K    
Sbjct: 447 EESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRR-----------LESNK---- 491

Query: 183 SGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRS 242
                                      PAGD  ++    +   +   E+ +       R 
Sbjct: 492 ---------------------------PAGDVDMSLSLLQEISSL-QEKLEVTRTDHQRE 523

Query: 243 HTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK-----EENEGFVKVTDAPNKS 297
            TSLK+      +   K      TA   ++        K     +EN   + +  +  ++
Sbjct: 524 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583

Query: 298 EISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD-----KDLSGYKGSSTP 352
            I+ H   Q A E   VS       E +E   +     ++ +D     ++L   + S   
Sbjct: 584 AIASH---QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 640

Query: 353 TKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNA 412
               E +A       + +E  ++   +   +D+  D        ++L+     L + + A
Sbjct: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED--------QHLVEMEDTLNKLQEA 692

Query: 413 LNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE---EKNRELEEELRKARAEAE 467
              VK    L AK +E T   D    +L+A ++  L L+   + + E + E++K R + E
Sbjct: 693 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752

Query: 468 DARQKAKD-DDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 526
            A ++ K  + + +  +++    TR    R L        +L  LQE +     ++ +  
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGREL--------KLTNLQENLSEVSQVKET-- 802

Query: 527 NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 586
                EK+   + + F+     + +  +  +  VN             + ++    + L 
Sbjct: 803 ----LEKELQILKEKFAEASEEAVSVQRSMQETVN------------KLHQKEEQFNMLS 846

Query: 587 GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 646
            D  K    L E      A  RE+   + + +KA  + E+   +    S          G
Sbjct: 847 SDLEK----LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS----------G 892

Query: 647 QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 706
              +++  +   + L+  D ++  +KL  A   N S  +       V A    ++ A   
Sbjct: 893 DNSSQLTKMNDELRLKERDVEELQLKLTKA-NENASFLQKSIEDMTVKAEQSQQEAAKKH 951

Query: 707 TEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
            E  K+     S L+K  +    Q +ELK + E
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKARYE 984


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 103/503 (20%), Positives = 198/503 (39%), Gaps = 64/503 (12%)

Query: 57   VLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEE--KFIEFEDSQEQEK 114
            V++N  S     +E  ++L+ LR  + +  ++ ++ +   + AE+  K +E E + E  K
Sbjct: 747  VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 806

Query: 115  KDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL 174
                TR    E Q R  ELK  N  + +S + + +  L+KE   L ++  E         
Sbjct: 807  ASSITR----ELQGR--ELKLTNLQENLSEVSQVKETLEKELQILKEKFAE--------- 851

Query: 175  ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
                   +S    ++ T +   +KE   +           +L+ D +K  E     + KF
Sbjct: 852  --ASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEKLRENLADMEAKF 898

Query: 235  QELSQP-----RSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVK 289
            +E  +      ++   L+++++++ +     ++  +  N ++     D       E  +K
Sbjct: 899  REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-----EELQLK 953

Query: 290  VTDA-PNKSEISKHIE-VQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYK 347
            +T A  N S + K IE + V  E           EEK E++  +      D++K +    
Sbjct: 954  LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS-----DLEKKMETSH 1008

Query: 348  GSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLL 407
                  K    +A         E L +    L+   D+   L G   E   L+ E  +L 
Sbjct: 1009 NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK---LKGAREENSGLLQELEELR 1065

Query: 408  ETKNALNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE-------EKNRELEEE 458
            +  +     +   D +  ++++T EK      LE  KQ   KL+       E N +  EE
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125

Query: 459  LRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN-QYKERLMELQEAVRW 517
            L K++ E      +  ++   +I T ++    + +    L E N +  E L   ++ V  
Sbjct: 1126 LNKSK-ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184

Query: 518  TEMIRASR---ENPAMQEKKRSS 537
             + +   R    N  ++ KKR S
Sbjct: 1185 HQKLEEERSVLNNQLLEMKKRES 1207



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 149/711 (20%), Positives = 278/711 (39%), Gaps = 113/711 (15%)

Query: 58   LENLDSVFAQDQE---HQVELELLRDDNEQLITQYERE-KALRKHAEEKFIEFEDSQEQE 113
            +ENL +   QD E   H  E+E LR    ++I + E   +A+R     K  + ED    E
Sbjct: 663  IENLQN--QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRS----KLDKAEDQHLVE 716

Query: 114  KKDLQTRVESLESQTRQLE-LKAK---------NYADQISRLEEREAELKKEYNALHQRH 163
             +D   +++  E + ++LE L+AK         N+  Q+   EE+  +L     A  +  
Sbjct: 717  MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776

Query: 164  TEM--IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ 221
            +EM  +   +E  E+ ++  L      ES+  S I +E         L   +  LT    
Sbjct: 777  SEMKKLRQQLEAAEK-QIKHLEIEKNAESSKASSITRE---------LQGRELKLT---- 822

Query: 222  KGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 281
                   + Q    E+SQ +   +L+ EL  + +  ++A+  A +    +         K
Sbjct: 823  -------NLQENLSEVSQVKE--TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873

Query: 282  EENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSE-VQAIIESTPELDMD 340
            EE    +        S++ K  E        N++   A+  EK E  + +I++  +L+ D
Sbjct: 874  EEQFNML-------SSDLEKLRE--------NLADMEAKFREKDEREEQLIKAKEKLEND 918

Query: 341  ----KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREV 396
                  +SG   S       E +  +R+ E L  +L+ A        +E A  L    E 
Sbjct: 919  IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA--------NENASFLQKSIED 970

Query: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVK----QAKLKLEEKN 452
              +  E +Q  E        K +L  K+ +L  + +    + + +K    +A  + + K+
Sbjct: 971  MTVKAEQSQ-QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 1029

Query: 453  RELEEELRKARAEAEDARQKAKDDDDSDIPTAQ--RKRFTRVEMARVLMERNQYKERLME 510
             E+ + L+K   + ED  + A++++   +   +  RK+  + + A       Q  E  M+
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA-------QTAEDAMQ 1082

Query: 511  LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPT-- 568
            + E     +M +   E  A  E  + +  +  + L +   N  K  E  +N      T  
Sbjct: 1083 IME-----QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVE 1136

Query: 569  SHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGR 628
            +      +K   TL Q    KS+    L EE    LA    + R+   +V +H + E+ R
Sbjct: 1137 NQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRD---EVTSHQKLEEER 1192

Query: 629  VQAFGWSLPQKYKQ---VTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGK 685
                   L  K ++   + +   E       + +    L EKD  ++        L    
Sbjct: 1193 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE-------KLRNEV 1245

Query: 686  TRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKN 736
            T   G    A   +  V  L+++  K     +  +  L+ +LKE +++L +
Sbjct: 1246 TVLRGENASAKSLHSVVQTLESDKVK----LELKVKNLELQLKENKRQLSS 1292



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 82/414 (19%), Positives = 162/414 (39%), Gaps = 55/414 (13%)

Query: 74   ELELLRDDNEQLITQY----EREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTR 129
            EL L   D E+L  +     E    L+K  E+  ++ E SQ++  K  +   + LE +  
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998

Query: 130  QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLE 189
             LE K +   +Q   L+ R      E      +H E++ N  + L  T+  +L G+ +  
Sbjct: 999  DLEKKMETSHNQCQELKARYERATSETKT---KHEEILQNLQKTLLDTE-DKLKGAREEN 1054

Query: 190  STAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDE 249
            S     + + R  +               D  K  +T        +++++ ++ T     
Sbjct: 1055 SGLLQELEELRKQA---------------DKAKAAQTAEDAMQIMEQMTKEKTETLAS-- 1097

Query: 250  LSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQ 309
            L D  Q  +K      T             LKE N   +K  +  NKS+    +E Q  +
Sbjct: 1098 LEDTKQTNAKLQNELDT-------------LKENN---LKNVEELNKSKELLTVENQKME 1141

Query: 310  ETRN-VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESL 368
            E R  + T      +KS+  + ++    + + ++L   +   T  + +E +    N + L
Sbjct: 1142 EFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1200

Query: 369  FEELSSAGSGLIGDVDEGADLLGMGREVENLIL--ENTQLLETKNALNIVKNDLIAKVDE 426
              E+    S  I D DE    L     + + +L  ++ +L + +N + +++ +       
Sbjct: 1201 --EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------- 1251

Query: 427  LTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD 480
                   L   ++ ++  K+KLE K + LE +L++ + +   +        D D
Sbjct: 1252 -NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADED 1304



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 133/694 (19%), Positives = 265/694 (38%), Gaps = 85/694 (12%)

Query: 70   EHQVELELLRDDNEQLITQYERE----KALRKHAEEKFIEFEDSQEQEKK---DLQTRVE 122
            E + EL L RD ++Q + + E +    + + + A+ + +E  +  E+EK+   DLQ RVE
Sbjct: 387  EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446

Query: 123  SLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL-ERTKLHQ 181
                    LE + K    + +R++E E  L  E     +   E+    +  + E++++ +
Sbjct: 447  EESITKGDLETQTKL---EHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503

Query: 182  LSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPR 241
            L     L     + +R+    +      PAGD  ++    +   +   E+ +       R
Sbjct: 504  LEKDLALRVQEVAELRRRLESN-----KPAGDVDMSLSLLQEISSL-QEKLEVTRTDHQR 557

Query: 242  SHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK-----EENEGFVKVTDAPNK 296
              TSLK+      +   K      TA   ++        K     +EN   + +  +  +
Sbjct: 558  EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 617

Query: 297  SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD-----KDLSGYKGSST 351
            + I+ H   Q A E   VS       E +E   +     ++ +D     ++L   + S  
Sbjct: 618  TAIASH---QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 674

Query: 352  PTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKN 411
                 E +A       + +E  ++   +   +D+  D        ++L+     L + + 
Sbjct: 675  AAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED--------QHLVEMEDTLNKLQE 726

Query: 412  ALNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE---EKNRELEEELRKARAEA 466
            A   VK    L AK +E T   D    +L+A ++  L L+   + + E + E++K R + 
Sbjct: 727  AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 786

Query: 467  EDARQKAKD-DDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 525
            E A ++ K  + + +  +++    TR    R L        +L  LQE +     ++ + 
Sbjct: 787  EAAEKQIKHLEIEKNAESSKASSITRELQGREL--------KLTNLQENLSEVSQVKET- 837

Query: 526  ENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQL 585
                  EK+   + + F+     + +  +  +  VN             + ++    + L
Sbjct: 838  -----LEKELQILKEKFAEASEEAVSVQRSMQETVN------------KLHQKEEQFNML 880

Query: 586  PGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTN 645
              D  K    L E      A  RE+   + + +KA  + E+   +    S          
Sbjct: 881  SSDLEK----LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS---------- 926

Query: 646  GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGL 705
            G   +++  +   + L+  D ++  +KL  A   N S  +       V A    ++ A  
Sbjct: 927  GDNSSQLTKMNDELRLKERDVEELQLKLTKA-NENASFLQKSIEDMTVKAEQSQQEAAKK 985

Query: 706  DTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 739
              E  K+     S L+K  +    Q +ELK + E
Sbjct: 986  HEEEKKELERKLSDLEKKMETSHNQCQELKARYE 1019



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 85/416 (20%), Positives = 158/416 (37%), Gaps = 67/416 (16%)

Query: 182 LSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG-----GETPGSE-QWKFQ 235
           +S   +  S + S + +   I  G   L  GD +L    + G     GET  ++ +W   
Sbjct: 185 ISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGV 244

Query: 236 ELSQPRSHTS----------------LKDELSDVSQGGSKATTPA-----------STAN 268
           EL +P                     L   +  V++ G  +TTPA           +T +
Sbjct: 245 ELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTS 304

Query: 269 SDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQ 328
           + +   P+ + L   +     V+  P+++ +      + A   R +S  +A  E   E Q
Sbjct: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA---RKISGTTALQEALKEKQ 361

Query: 329 AIIEST-PELDMDK----DLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDV 383
             IE    E D+++      + + G       +     D++   L  ++    + +    
Sbjct: 362 QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421

Query: 384 DEGADLLGM----GREVENLILENTQLLETKNALNIVKNDLIAKVDELT-------CEKD 432
            E  +LL       R+VE+L     +   TK  L        A++ EL         + D
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD 481

Query: 433 VLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQK------AKDDDDS-----DI 481
            LQ ELE  + A +  + +  ELE++L     E  + R++      A D D S     +I
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541

Query: 482 PTAQRK-RFTRVEMARVLMERNQY---KERLMELQEAVRWTEMIRASRENPAMQEK 533
            + Q K   TR +  R +    ++   +E   + +    +T   + S+EN +++ K
Sbjct: 542 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 597


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 123/601 (20%), Positives = 232/601 (38%), Gaps = 58/601 (9%)

Query: 79   RDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNY 138
            R + E  ++Q E+EK L +H   ++    + + +++++++  V +L+ Q   L+  ++N 
Sbjct: 474  RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533

Query: 139  ADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRI-- 196
                 +L + + +L++  + L       +     H E +K      S   E    +RI  
Sbjct: 534  QLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILE 593

Query: 197  RKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQG 256
              +       + L A       D     E  G  Q +   L +   H  LK  L  V   
Sbjct: 594  NSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKH--LKHNLEKVEGE 651

Query: 257  GSKATTPASTANSDVATIPTDTPLK----------EENEGFV---KVTDAPNKSEISKHI 303
              +A    + +  +   +  D   K          E NE  V   ++TD     E +K +
Sbjct: 652  RKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSV 711

Query: 304  EVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFD- 362
             +   ++       + E  E   VQ  IE    + +D DL   +       G + +  D 
Sbjct: 712  AMCEMEKKLKEEREAREKAENRVVQ--IEKQCSM-LDVDLKQSQQKLEHLTGNKERMEDE 768

Query: 363  -RNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVENLILENTQLLETKNALNIVK 417
             +N     E+ S+    L  ++     E  +L G+ ++++  I  NT LLE K  L    
Sbjct: 769  VKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEI--NT-LLEAKRLLEFEL 825

Query: 418  NDLIAKVDELTCEKDVLQGELEA-----------VKQAKLKLEEKNRELEEELRKARAEA 466
              L  +      +   LQ +LEA           VK+ K ++EEKNRE  +++++ + E 
Sbjct: 826  AQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEK 885

Query: 467  E------DARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYK-----ERLMELQEA- 514
            E      D  +   + +       + + F   + ++    RN+ +       +  L+EA 
Sbjct: 886  ETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEAN 945

Query: 515  ---VRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHV 571
                +  E++R  REN  + EK + +  ++        SN     E  +N +    T  V
Sbjct: 946  SMLTKDIEILR--RENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAV 1003

Query: 572  TPSVKKRSSTLSQLPGDKSKAFDFLSEETE-ASLASRREQKREQYRQVKAHVQKEDGRVQ 630
                +  +    ++   K+   D   +E E   L     Q+RE++ Q+    QKE   +Q
Sbjct: 1004 NKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQ 1063

Query: 631  A 631
            A
Sbjct: 1064 A 1064



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 103/510 (20%), Positives = 208/510 (40%), Gaps = 49/510 (9%)

Query: 34   EFERLIGRYDEEVVKELMPLVVAVLE-------NLDSVFAQDQEHQVELELLRDDNEQL- 85
            E ER    +D E++ +L   + ++ E       NL+ V  + +E Q  L     +   L 
Sbjct: 611  EAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLE 670

Query: 86   ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRL 145
            I    + K+L++  E++  E + ++ +     Q+  E+      ++E K K   +   + 
Sbjct: 671  IDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKA 730

Query: 146  EEREAELKKEYNALHQRHTEMIHNYMEHL----ERTKLHQLSGSDQLESTAHSRIRKERP 201
            E R  +++K+ + L     +     +EHL    ER +    + + QLE  ++ R+  +  
Sbjct: 731  ENRVVQIEKQCSMLDV-DLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNE 789

Query: 202  ISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP----RSHTSLKDELSDVSQGG 257
            +    F      GL     Q+      +++    EL+Q     R +     EL D  +  
Sbjct: 790  LKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAE 849

Query: 258  SKATTPASTANSDVATIPTDTPLKEEN-EGFVKVTDAPNKSE-ISKHIEV-QVAQETRNV 314
               +T   T   ++        ++E+N E   K+ +  N+ E ++  +++ +   E+  +
Sbjct: 850  QYFSTLYKTQVKELKE-----EIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQL 904

Query: 315  STGSAENE-----EKSEVQAIIESTPELDMDKDLSGYK-GSSTPTKGIENKAFDRNTESL 368
            + G  E +     ++S+  A        D D  +S  +  +S  TK IE     R  E L
Sbjct: 905  ARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIE--ILRRENEEL 962

Query: 369  FEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELT 428
             E++  A         E    L    E+ NL     + + T+  L   K   + K+ E+ 
Sbjct: 963  TEKMKKA---------EEEYKLEKEEEISNLKAAFEKNINTERTL---KTQAVNKLAEIM 1010

Query: 429  CEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAED---ARQKAKDDDDSD-IPTA 484
              KD      +A  Q   K E++NR+L+ EL + R +        QK  +D  +  +   
Sbjct: 1011 NRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEEC 1070

Query: 485  QRKRFTRVEMARVLMERNQYKERLMELQEA 514
              +   ++++A    +  Q + +L++L ++
Sbjct: 1071 AHRNELQMQLASKESDIEQLRAKLLDLSDS 1100


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 153/707 (21%), Positives = 272/707 (38%), Gaps = 101/707 (14%)

Query: 22   ERVSGLAGSIYREFERLIGRYDE-EVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRD 80
            E +     S+  +++ L+  Y++    KE M L +    +LD   A      +E +  +D
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA------LERKTKKD 547

Query: 81   DNEQLITQYEREKALRKHAE------------------------EKFIEFEDSQEQE--K 114
               QLI +    K L KHAE                        +K  E+ DSQ+ E  K
Sbjct: 548  QEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIK 607

Query: 115  KDLQTRVESLE--SQTRQLELKAKNYADQISR----LEEREAELKKEYNALHQRHTEM-- 166
             DL   +ES+E   Q +Q    A+  A    R    L     ELK++   L   + +M  
Sbjct: 608  MDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667

Query: 167  -IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLP-----AGDGLLTPDA 220
             I  Y   LE  K  Q+    +L+S A + I K   +  G  P         +G +T D 
Sbjct: 668  DIQLYQSQLEAKKKMQVDLEKELQS-AFNEITKLTSLIDGKVPKDLLCNLELEGKIT-DL 725

Query: 221  QKGGETPGSEQWKFQE----LSQPRSHTS----LKDELSDVSQGGSKATTPASTANSDVA 272
            QK       E    +E    LS+ +S  S    L+ E+ D S+     T+      S+V 
Sbjct: 726  QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785

Query: 273  TIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEV----- 327
               +      E  G  K   A  +S           QE +N  T   + E+K ++     
Sbjct: 786  HKESRVQGLLEEIGKTKDDLATTQSNYK-----STDQEFQNFKTLHMDFEQKYKMVLEEN 840

Query: 328  ----QAIIESTPELD-MDKDLSGYKGS-STPTKGIENKAFDRNTESLFEELSSAGSGLIG 381
                Q I+  + E    D  L   K   S  T+ ++ K   R  +    E+      L  
Sbjct: 841  ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKT--REVQERLNEMEQLKEQL-- 896

Query: 382  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 441
              +  + L  + RE   +  +  Q LE    L   K+DL    + L  E+D L+ ++   
Sbjct: 897  -ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955

Query: 442  KQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDI----PTAQRKRFTRVEMARV 497
                +  +E+ R   E L++ +      + K  ++   ++     T + K   + +M  +
Sbjct: 956  VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015

Query: 498  LMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSS--NTTKK 555
              +++   +    L   V+  E+I   R+  ++ ++K + + Q    + +      T  K
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK-NELQQMLESVIAEKEQLKTDLK 1074

Query: 556  PEPPVNLKYNAPTSHVTPSVKKRSSTLSQ-------LPGDKSKAFDFLSEETEASLASRR 608
                + ++       +   +KK+   ++Q         G+ S+  D L+ E E  L  + 
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA-EVEEKLKEKS 1133

Query: 609  EQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNL 655
            +Q +E+ +Q+  +VQ+E   +Q       +K  ++ N + E K K L
Sbjct: 1134 QQLQEKQQQL-LNVQEEMSEMQ-------KKINEIENLKNELKNKEL 1172



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 120/611 (19%), Positives = 232/611 (37%), Gaps = 73/611 (11%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDD--NEQLITQYEREKALRKHAE- 100
            E V+ E   L   + EN++       E+Q EL LL D+   +Q I   E+  A++K  E 
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTI----ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115

Query: 101  ----EKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEY 156
                ++  E E+  +++ + LQ + + L +   ++    K    +I+ +E  + ELK + 
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK----KINEIENLKNELKNKE 1171

Query: 157  NALHQRHTEMIH---NYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGD 213
              L    TE +       E+ E  K   ++   ++          ER    G        
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVK--SITKERKVLKELQKSFETERDHLRGYIREIEAT 1229

Query: 214  GLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVAT 273
            GL T            E+ K   +       ++ +    VS+  ++         S    
Sbjct: 1230 GLQT-----------KEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKL 1278

Query: 274  IPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAE--------NEEKS 325
                  L EE E    V +     E    +E+   Q T   ST  A         NE+  
Sbjct: 1279 QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338

Query: 326  EVQAIIES-TPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD 384
            E Q  I+S T E D  K +      +   K  + K   R T +  +E  S     +   +
Sbjct: 1339 ESQEEIKSLTKERDNLKTIK----EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394

Query: 385  EGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTC---EKD-------VL 434
            +  +   +  E+E    +++ LL  +  +  +   L    DE+     EKD       VL
Sbjct: 1395 KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVL 1454

Query: 435  QGELEAVKQAKLKLEEKNRELEEELRKARA---EAEDARQKAK---DDDDSDIPTAQRKR 488
            Q E + +K+   ++  K+ E EEEL+ A     E E+   + +    + +++I T Q++ 
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514

Query: 489  FTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSS 548
                +  +  ++    KE    +++     E +   ++    ++ K S++    S++   
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML-E 1573

Query: 549  SSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRR 608
             +N  ++ +  + +              KR     Q+  D+      L E T+  +A  +
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEE------MKRVQEALQIERDQ------LKENTKEIVAKMK 1621

Query: 609  EQKREQYRQVK 619
            E + ++Y+ +K
Sbjct: 1622 ESQEKEYQFLK 1632



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 107/507 (21%), Positives = 206/507 (40%), Gaps = 60/507 (11%)

Query: 47   VKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQ-YEREKALR----KHAEE 101
            +KE    +  +  NL     +    Q +LE + D  +  I + YE+E+          +E
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQE 1545

Query: 102  KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQ 161
            K  E +  +E  K    + ++S+ES+  +L  + +   ++I  + + + E+K+   AL  
Sbjct: 1546 KVNELKQFKEHRKAK-DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604

Query: 162  RHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ 221
               ++  N  E + + K  Q      L+ TA +  +++      +        L   + +
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664

Query: 222  KGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 281
               E     Q   + L + RS T  +D+L  V +                 T+  +    
Sbjct: 1665 T--ENIRLTQILHENLEEMRSVTKERDDLRSVEE-----------------TLKVERDQL 1705

Query: 282  EENEGFVKVTDAPNKSEIS-KHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 340
            +EN       D   + E+   H+ ++  QET +   G   +E+ +E+          +M 
Sbjct: 1706 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV-SEKTNEIS---------NMQ 1755

Query: 341  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGAD-LLGMGREVENL 399
            KDL  +   +   + ++ +   R      +E       L G V E  D L  M +++EN 
Sbjct: 1756 KDLE-HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN- 1813

Query: 400  ILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEEL 459
               N +L E    L   ++ LI      T +KDV + + +  +  +LK + K++ L   L
Sbjct: 1814 --SNAKLQEKIQELKANEHQLI------TLKKDVNETQKKVSEMEQLKKQIKDQSL--TL 1863

Query: 460  RKARAEAEDARQKAKDD-DDSDIPTAQRKRFTRVEMARVLMERNQYKERL-------MEL 511
             K   E  +  QK  ++ ++      +R    RVE   + +ER+Q KE L       +E+
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE-ETLKLERDQLKESLQETKARDLEI 1922

Query: 512  QEAVRWTEMIRASRENPAMQEKKRSSI 538
            Q+ ++   M+  S+E+    +K R  I
Sbjct: 1923 QQELKTARML--SKEHKETVDKLREKI 1947



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 102/598 (17%), Positives = 232/598 (38%), Gaps = 52/598 (8%)

Query: 30   SIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQY 89
            S + E  +L    D +V K+L+      LE    +    +E   E+E      E++I   
Sbjct: 692  SAFNEITKLTSLIDGKVPKDLL----CNLELEGKITDLQKELNKEVEENEALREEVILLS 747

Query: 90   EREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEERE 149
            E  K+L    E    E +D  E E   + +  + L S+    E + +   ++I + ++  
Sbjct: 748  EL-KSLPSEVERLRKEIQDKSE-ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805

Query: 150  AELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPL 209
            A  +  Y +  Q        +M+  ++ K+  L  ++++     +  ++ +     +  L
Sbjct: 806  ATTQSNYKSTDQEFQNFKTLHMDFEQKYKM-VLEENERMNQEIVNLSKEAQKFDSSLGAL 864

Query: 210  PAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDE-LSDVSQGGSKATTPASTAN 268
                   T + Q   E     Q +  E+ Q +     +D  L  V +  +  T       
Sbjct: 865  KTELSYKTQELQ---EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921

Query: 269  SDVATIPTDTPLKEENEGFVKVTDAPNKSEI--SKHIEVQVAQETRNVSTGSAENEEKSE 326
             +V T+  +    ++ +  +++     KS+I  + ++ +   ++ RN      +++E   
Sbjct: 922  EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI- 980

Query: 327  VQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG 386
                  +T +  + +++S             N   + NT    +E      G    +D+ 
Sbjct: 981  ------NTLKSKISEEVS------------RNLHMEENTGETKDEFQQKMVG----IDKK 1018

Query: 387  ADLLGMGREVENLILENTQLLETKNALNIV---KNDLIAKVDELTCEKDVLQGELEAVKQ 443
             DL     +     +++ +++E +  +  +   KN+L   ++ +  EK+ L+ +L+   +
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 444  AKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTR---VEMARVLME 500
              ++ +E+ R L +EL+K +      +  A   +     T  R         E ++ L E
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138

Query: 501  RNQ----YKERLMELQEAVRWTEMIRASRENPAM----QEKKRSSIWQFFSRLFSSSSNT 552
            + Q     +E + E+Q+ +   E ++   +N  +     E +R  + Q  +  +    + 
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198

Query: 553  TKKPEPPVNLK--YNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRR 608
            TK+ +    L+  +     H+   +++  +T  Q   +   A   L E  E     RR
Sbjct: 1199 TKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR 1256


>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 105/487 (21%), Positives = 188/487 (38%), Gaps = 37/487 (7%)

Query: 72  QVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQL 131
           + ELE LR    QL+ + E  + L    E+  +E +   E E+     + E    Q +QL
Sbjct: 55  ETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL 114

Query: 132 ELKAKNYADQISRLE-EREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLES 190
           + + ++  ++IS LE E+E+ELK+    LH    E I +  +  E +     S    L+ 
Sbjct: 115 QGELRSLREEISLLEHEKESELKEIEQELHLAQAE-IQSLRQAAEDSATEHESDIASLQE 173

Query: 191 TA---------HSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPR 241
                        RIR +  + +             P    G       Q + QEL + R
Sbjct: 174 DLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE-R 232

Query: 242 SHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISK 301
            H  L +E   + +  S  T   +   S+     T+  L+ +    + +T A +++    
Sbjct: 233 YHF-LNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQT---LSMTSAESQTSEMD 288

Query: 302 HIEVQVAQETRNVSTGSAENEE---KSEVQAIIESTPELDMDKDLSG--YKGSSTPTKGI 356
            +E     +        AE +    K++ Q +     EL   + +S    +      K  
Sbjct: 289 FLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA 348

Query: 357 ENKAFDRNTESLF---EELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNAL 413
           +N+     T       EEL S    L    D   D      E   L+    QL      L
Sbjct: 349 QNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQD------EQNELLKMQLQLQTELRQL 402

Query: 414 NIVKNDLIAKVDE--LTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQ 471
            ++K+ L+    E  L C    L  + + V   K KL E+ ++L+EEL+   AE +  R 
Sbjct: 403 KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD 462

Query: 472 KA---KDDDDSDIPT-AQRKRFTRV-EMARVLMERNQYKERLMELQEAVRWTEMIRASRE 526
                K+ ++ D  T AQ +   ++ + ++  +ER ++    +E    +   E+      
Sbjct: 463 TVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKAS 522

Query: 527 NPAMQEK 533
           +P  ++K
Sbjct: 523 HPIPEDK 529



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 46/173 (26%), Positives = 82/173 (47%), Gaps = 24/173 (13%)

Query: 320 ENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGL 379
           E EE+ E + + E   ++         KG S  +  +        TE+  EEL +    L
Sbjct: 17  EEEEEEEEEEVEEEEEQVQ--------KGGSVGSLSVNKHRGLSLTETELEELRAQVLQL 68

Query: 380 IGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELE 439
           + +++E  +L G   + E+  LE   LLE +   +  + ++  K      +   LQGEL 
Sbjct: 69  VAELEETRELAG---QHEDDSLELQGLLEDERLASAQQAEVFTK------QIQQLQGELR 119

Query: 440 AVKQAKLKLEEKN----RELEEELRKARAEAEDARQKAKD---DDDSDIPTAQ 485
           ++++    LE +     +E+E+EL  A+AE +  RQ A+D   + +SDI + Q
Sbjct: 120 SLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQ 172


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,167,616
Number of Sequences: 37866
Number of extensions: 2478914
Number of successful extensions: 18401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 773
Number of HSP's that attempted gapping in prelim test: 11074
Number of HSP's gapped (non-prelim): 5936
length of query: 1307
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1193
effective length of database: 13,930,794
effective search space: 16619437242
effective search space used: 16619437242
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.