Search of human proteins with 25777684

Search of human proteins with 25777684

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777684 Ras association domain family 1 isoform D [Homo
sapiens]
         (344 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777684 Ras association domain family 1 isoform D [Homo sapi...   708   0.0  
gi|20149588 Ras association domain family 1 isoform A [Homo sapi...   693   0.0  
gi|25777682 Ras association domain family 1 isoform C [Homo sapi...   442   e-124
gi|25777680 Ras association domain family 1 isoform B [Homo sapi...   378   e-105
gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isofor...   269   3e-72
gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isofor...   228   8e-60
gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isofor...   176   4e-44
gi|30039698 Ras association (RalGDS/AF-6) domain family member 3...   167   1e-41
gi|23510360 Ras association domain family 4 [Homo sapiens]             62   7e-10
gi|25777677 Ras association domain family 2 [Homo sapiens]             62   1e-09
gi|7661964 Ras association domain family 2 [Homo sapiens]              62   1e-09
gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isofor...    59   6e-09
gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isofor...    59   6e-09
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    53   3e-07
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    53   3e-07
gi|5031689 protein kinase D3 [Homo sapiens]                            52   1e-06
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    51   2e-06
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    51   2e-06
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    51   2e-06
gi|28557781 protein kinase C, eta [Homo sapiens]                       50   2e-06
gi|133908623 protein kinase C, iota [Homo sapiens]                     50   3e-06
gi|47157325 protein kinase C, delta [Homo sapiens]                     50   4e-06
gi|31377782 protein kinase C, delta [Homo sapiens]                     50   4e-06
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]            49   5e-06
gi|13384594 protein kinase C, gamma [Homo sapiens]                     49   9e-06
gi|120659787 protein kinase D2 isoform B [Homo sapiens]                48   1e-05
gi|120659785 protein kinase D2 isoform A [Homo sapiens]                48   1e-05
gi|120659782 protein kinase D2 isoform A [Homo sapiens]                48   1e-05
gi|19923468 protein kinase D2 isoform A [Homo sapiens]                 48   1e-05
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]    48   1e-05

>gi|25777684 Ras association domain family 1 isoform D [Homo
           sapiens]
          Length = 344

 Score =  708 bits (1827), Expect = 0.0
 Identities = 344/344 (100%), Positives = 344/344 (100%)

Query: 1   MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
           MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
Sbjct: 1   MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60

Query: 61  THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 120
           THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD
Sbjct: 61  THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 120

Query: 121 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 180
           TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV
Sbjct: 121 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 180

Query: 181 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 240
           PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV
Sbjct: 181 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 240

Query: 241 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 300
           DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF
Sbjct: 241 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 300

Query: 301 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 344
           SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 301 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 344


>gi|20149588 Ras association domain family 1 isoform A [Homo
           sapiens]
          Length = 340

 Score =  693 bits (1789), Expect = 0.0
 Identities = 339/344 (98%), Positives = 339/344 (98%), Gaps = 4/344 (1%)

Query: 1   MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
           MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
Sbjct: 1   MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60

Query: 61  THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 120
           THTWCDLCGDFIWGVVRKGLQCA     CKFTCHYRCRALVCLDCCGPRDLGWEPAVERD
Sbjct: 61  THTWCDLCGDFIWGVVRKGLQCAH----CKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 116

Query: 121 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 180
           TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV
Sbjct: 117 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 176

Query: 181 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 240
           PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV
Sbjct: 177 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 236

Query: 241 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 300
           DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF
Sbjct: 237 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 296

Query: 301 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 344
           SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 297 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 340


>gi|25777682 Ras association domain family 1 isoform C [Homo
           sapiens]
          Length = 270

 Score =  442 bits (1138), Expect = e-124
 Identities = 221/221 (100%), Positives = 221/221 (100%)

Query: 124 DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS 183
           DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS
Sbjct: 50  DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS 109

Query: 184 KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP 243
           KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP
Sbjct: 110 KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP 169

Query: 244 RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP 303
           RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP
Sbjct: 170 RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP 229

Query: 304 ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 344
           ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 230 ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 270


>gi|25777680 Ras association domain family 1 isoform B [Homo
           sapiens]
          Length = 189

 Score =  378 bits (970), Expect = e-105
 Identities = 189/189 (100%), Positives = 189/189 (100%)

Query: 156 MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV 215
           MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV
Sbjct: 1   MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV 60

Query: 216 KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL 275
           KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL
Sbjct: 61  KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL 120

Query: 276 AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ 335
           AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ
Sbjct: 121 AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ 180

Query: 336 EALHACPLG 344
           EALHACPLG
Sbjct: 181 EALHACPLG 189


>gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isoform A
           [Homo sapiens]
          Length = 418

 Score =  269 bits (687), Expect = 3e-72
 Identities = 147/301 (48%), Positives = 195/301 (64%), Gaps = 21/301 (6%)

Query: 49  GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLD 104
           G GH F     P GP    WCDLCG     V+R+ L+C     +CKFTCH  CR+L+ LD
Sbjct: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCT----NCKFTCHPECRSLIQLD 169

Query: 105 CCGPRDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMS 157
           C     L  +      T       NV +PVE      +  EI+QKI  YN +  + L M 
Sbjct: 170 CSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMK 229

Query: 158 LNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKH 217
           L++DG+YTGFIKV LKL RPV+VP+  +P S+ DA +      +  +RTSFYLP DA+K 
Sbjct: 230 LSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQ 289

Query: 218 LHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAG 277
           LH+ S T   EVI+ LL+KF+VVD+P+KFALF+R  + GQV  +KL   ++PL LRLLAG
Sbjct: 290 LHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAG 349

Query: 278 PSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEA 337
           P  + LSFVLKEN++GEV WDAFS+PEL NFL IL++EE++ ++Q+ +KY   RQK++EA
Sbjct: 350 PDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEA 409

Query: 338 L 338
           L
Sbjct: 410 L 410


>gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isoform C
           [Homo sapiens]
          Length = 265

 Score =  228 bits (580), Expect = 8e-60
 Identities = 116/217 (53%), Positives = 157/217 (72%)

Query: 122 NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVP 181
           NV +PVE      +  EI+QKI  YN +  + L M L++DG+YTGFIKV LKL RPV+VP
Sbjct: 41  NVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVP 100

Query: 182 SSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVD 241
           +  +P S+ DA +      +  +RTSFYLP DA+K LH+ S T   EVI+ LL+KF+VVD
Sbjct: 101 AGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVD 160

Query: 242 DPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFS 301
           +P+KFALF+R  + GQV  +KL   ++PL LRLLAGP  + LSFVLKEN++GEV WDAFS
Sbjct: 161 NPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFS 220

Query: 302 MPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEAL 338
           +PEL NFL IL++EE++ ++Q+ +KY   RQK++EAL
Sbjct: 221 IPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 257


>gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isoform B
           [Homo sapiens]
          Length = 336

 Score =  176 bits (445), Expect = 4e-44
 Identities = 101/221 (45%), Positives = 132/221 (59%), Gaps = 21/221 (9%)

Query: 49  GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLD 104
           G GH F     P GP    WCDLCG     V+R+ L+C     +CKFTCH  CR+L+ LD
Sbjct: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCT----NCKFTCHPECRSLIQLD 169

Query: 105 CCGPRDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMS 157
           C     L  +      T       NV +PVE      +  EI+QKI  YN +  + L M 
Sbjct: 170 CSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMK 229

Query: 158 LNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKH 217
           L++DG+YTGFIKV LKL RPV+VP+  +P S+ DA +      +  +RTSFYLP DA+K 
Sbjct: 230 LSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQ 289

Query: 218 LHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQV 258
           LH+ S T   EVI+ LL+KF+VVD+P+KFALF+R  + GQV
Sbjct: 290 LHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQV 330


>gi|30039698 Ras association (RalGDS/AF-6) domain family member 3
           [Homo sapiens]
          Length = 238

 Score =  167 bits (423), Expect = 1e-41
 Identities = 95/207 (45%), Positives = 127/207 (61%), Gaps = 26/207 (12%)

Query: 134 LSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRP--VSVPSSKKPPSLQD 191
           LS+ EI++K+ +YN  +   L M+LN +G YTGFIKVQ++L +P   S  S K  PS   
Sbjct: 49  LSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPS--- 105

Query: 192 ARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFER 251
                                  +  LH+ S     EVIEALL+KFLV + P KFAL++R
Sbjct: 106 -------------------SNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKR 146

Query: 252 AERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRI 311
             R  QVY  KL D E PL LRL+AGP    LSFVL+E++ GE  W+AFS+PEL NFLRI
Sbjct: 147 CHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGE--WEAFSLPELQNFLRI 204

Query: 312 LQREEEEHLRQILQKYSYCRQKIQEAL 338
           L +EE+E L+ + ++Y+  RQK++EAL
Sbjct: 205 LDKEEDEQLQNLKRRYTAYRQKLEEAL 231


>gi|23510360 Ras association domain family 4 [Homo sapiens]
          Length = 321

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 53/173 (30%), Positives = 78/173 (45%), Gaps = 32/173 (18%)

Query: 194 RGPGRGTSVRR------------RTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVV 240
           R PG    +RR            +TS + P   +V ++ V S     +V+  LL KF V 
Sbjct: 154 RAPGEAQRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVE 213

Query: 241 DDPRKFALF---ERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSG---- 293
           D P +FAL+   E  ER       KL D E PL  R+L GP +K     L E D G    
Sbjct: 214 DGPSEFALYIVHESGER------TKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVP 267

Query: 294 --EVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCR----QKIQEALHA 340
                +  F MP L +F+  L+ EEE  + ++  K+   R    Q++++ + A
Sbjct: 268 HEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEA 320


>gi|25777677 Ras association domain family 2 [Homo sapiens]
          Length = 326

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 199 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 257
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229

Query: 258 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 311
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289

Query: 312 LQREEEEHLRQILQKYSYCRQKIQEAL 338
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316


>gi|7661964 Ras association domain family 2 [Homo sapiens]
          Length = 326

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 199 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 257
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229

Query: 258 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 311
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289

Query: 312 LQREEEEHLRQILQKYSYCRQKIQEAL 338
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316


>gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isoform b
           [Homo sapiens]
          Length = 369

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 15/139 (10%)

Query: 199 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFAL---FERAER 254
           G      TS ++P  ++   + V S  R  EVI+ LL+KF + + P+ FAL   F   E+
Sbjct: 215 GHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ 274

Query: 255 HGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDA-----FSMPELHNFL 309
                 R+L   + PL  RLL GPS+K     L + D+ E++ D      F    L + L
Sbjct: 275 ------RRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESIL 328

Query: 310 RILQREEEEHLRQILQKYS 328
           + L  EE+  +++I+ K++
Sbjct: 329 QRLNEEEKREIQRIVTKFN 347


>gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isoform a
           [Homo sapiens]
          Length = 337

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 15/139 (10%)

Query: 199 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFAL---FERAER 254
           G      TS ++P  ++   + V S  R  EVI+ LL+KF + + P+ FAL   F   E+
Sbjct: 183 GHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ 242

Query: 255 HGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDA-----FSMPELHNFL 309
                 R+L   + PL  RLL GPS+K     L + D+ E++ D      F    L + L
Sbjct: 243 ------RRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESIL 296

Query: 310 RILQREEEEHLRQILQKYS 328
           + L  EE+  +++I+ K++
Sbjct: 297 QRLNEEEKREIQRIVTKFN 315


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 4/57 (7%)

Query: 49  GRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           G  H FQ       T+CD C  F+WGV+++G +C     DC   CH +C+ LV  +C
Sbjct: 504 GFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRC----KDCGMNCHKQCKDLVVFEC 556


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 4/57 (7%)

Query: 49  GRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           G  H FQ       T+CD C  F+WGV+++G +C     DC   CH +C+ LV  +C
Sbjct: 539 GFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRC----KDCGMNCHKQCKDLVVFEC 591


>gi|5031689 protein kinase D3 [Homo sapiens]
          Length = 890

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 5/84 (5%)

Query: 52  HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDL 111
           H F        T C  C   + G+ R+G+QC     DCKF CH RC + V  DC G    
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCK----DCKFNCHKRCASKVPRDCLGEVTF 327

Query: 112 GWEPAVERDTNVDEPVEWETPDLS 135
             EP+    T+ D P++ +  D++
Sbjct: 328 NGEPS-SLGTDTDIPMDIDNNDIN 350



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 19/47 (40%), Positives = 27/47 (57%), Gaps = 4/47 (8%)

Query: 63  TWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           T+CD CG+ +WG+VR+GL+C      C    H RC   +  +C G R
Sbjct: 166 TFCDYCGEMLWGLVRQGLKC----EGCGLNYHKRCAFKIPNNCSGVR 208


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 4/58 (6%)

Query: 48  PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           PG  H FQ       T+C+ C  F+WG++++G +C     DC   CH +C+ L+ L C
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKC----KDCGANCHKQCKDLLVLAC 544


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 4/58 (6%)

Query: 48  PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           PG  H FQ       T+C+ C  F+WG++++G +C     DC   CH +C+ L+ L C
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKC----KDCGANCHKQCKDLLVLAC 544


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 4/58 (6%)

Query: 48  PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           PG  H FQ       T+C+ C  F+WG++++G +C     DC   CH +C+ L+ L C
Sbjct: 490 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKC----KDCGANCHKQCKDLLVLAC 543


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 4/54 (7%)

Query: 52  HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           H+F        T+CD CG  +WG++R+GLQC      CK   H RC+A V  +C
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC----KICKMNVHIRCQANVAPNC 295



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 51  GHRFQPAGPATHTWCDLCGDFIWGVV-RKGLQCARLSADCKFTCHYRCRALVCLDC 105
           GH+F        T+C  C +FIWGV  ++G QC      C    H RC  L+   C
Sbjct: 171 GHKFMATYLRQPTYCSHCREFIWGVFGKQGYQC----QVCTCVVHKRCHHLIVTAC 222


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 5/77 (6%)

Query: 44  RQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCL 103
           R+L    GH FQ         C +C D IWG+ R+G +C     +CK   H +C  LV +
Sbjct: 133 RKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKC----INCKLLVHKKCHKLVTI 188

Query: 104 DCCGPRDLGWEPAVERD 120
           + CG   L  EP +  D
Sbjct: 189 E-CGRHSLPQEPVMPMD 204


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 22/56 (39%), Positives = 33/56 (58%), Gaps = 5/56 (8%)

Query: 52  HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCG 107
           HRF+     + T+CD CG  +WG+V++GL+C     DC    H++CR  V  + CG
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKC----EDCGMNVHHKCREKVA-NLCG 281



 Score = 37.7 bits (86), Expect = 0.015
 Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query: 50  RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           + H F        T+C +C DF+WG+ ++G +C +    C    H +C   +   C G  
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQ----CNAAIHKKCIDKIIGRCTGTA 212

Query: 110 DLGWEPAVERDT-NVDEP 126
               +   +++  N+D P
Sbjct: 213 ANSRDTIFQKERFNIDMP 230


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 22/56 (39%), Positives = 33/56 (58%), Gaps = 5/56 (8%)

Query: 52  HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCG 107
           HRF+     + T+CD CG  +WG+V++GL+C     DC    H++CR  V  + CG
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKC----EDCGMNVHHKCREKVA-NLCG 281



 Score = 37.7 bits (86), Expect = 0.015
 Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query: 50  RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           + H F        T+C +C DF+WG+ ++G +C +    C    H +C   +   C G  
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQ----CNAAIHKKCIDKIIGRCTGTA 212

Query: 110 DLGWEPAVERDT-NVDEP 126
               +   +++  N+D P
Sbjct: 213 ANSRDTIFQKERFNIDMP 230


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 32/93 (34%), Positives = 41/93 (44%), Gaps = 8/93 (8%)

Query: 44  RQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCL 103
           R+L    GH FQ        +C  C + IWG+ R+G +C     +CK   H RC  LV L
Sbjct: 123 RKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRC----INCKLLVHKRCHGLVPL 178

Query: 104 DCCGPRDL---GWEPAVERDTNVDEPVEWETPD 133
            C    D      EP V+ D N D  +  E  D
Sbjct: 179 TCRKHMDSVMPSQEPPVD-DKNEDADLPSEETD 210


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%)

Query: 50  RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCG 107
           + H+F        T+C  C DFIWG+ ++GLQC      C F  H RC   V  +C G
Sbjct: 34  KSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQC----QVCSFVVHRRCHEFVTFECPG 87



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 16/50 (32%), Positives = 29/50 (58%), Gaps = 4/50 (8%)

Query: 48  PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRC 97
           P   H+F+    ++ T+CD CG  ++G+V +G++C    + C+   H RC
Sbjct: 97  PRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKC----SCCEMNVHRRC 142


>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
          Length = 721

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/76 (39%), Positives = 36/76 (47%), Gaps = 15/76 (19%)

Query: 63  TWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTN 122
           T C  C   + G+ R+GLQC     DCKF CH RC   V  DC G          E   N
Sbjct: 119 TVCQACKKLLKGLFRQGLQCK----DCKFNCHKRCATRVPNDCLG----------EALIN 164

Query: 123 VDEPVEWETPDLSQAE 138
            D P+E E  D S+A+
Sbjct: 165 GDVPME-EATDFSEAD 179


>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/76 (39%), Positives = 36/76 (47%), Gaps = 15/76 (19%)

Query: 63  TWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTN 122
           T C  C   + G+ R+GLQC     DCKF CH RC   V  DC G          E   N
Sbjct: 276 TVCQACKKLLKGLFRQGLQCK----DCKFNCHKRCATRVPNDCLG----------EALIN 321

Query: 123 VDEPVEWETPDLSQAE 138
            D P+E E  D S+A+
Sbjct: 322 GDVPME-EATDFSEAD 336



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 4/46 (8%)

Query: 64  WCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           +CD CG+ ++G+VR+GL+C      C    H RC   +  +C G R
Sbjct: 151 FCDHCGEMLFGLVRQGLKC----DGCGLNYHKRCAFSIPNNCSGAR 192


>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/76 (39%), Positives = 36/76 (47%), Gaps = 15/76 (19%)

Query: 63  TWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTN 122
           T C  C   + G+ R+GLQC     DCKF CH RC   V  DC G          E   N
Sbjct: 276 TVCQACKKLLKGLFRQGLQCK----DCKFNCHKRCATRVPNDCLG----------EALIN 321

Query: 123 VDEPVEWETPDLSQAE 138
            D P+E E  D S+A+
Sbjct: 322 GDVPME-EATDFSEAD 336



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 4/46 (8%)

Query: 64  WCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           +CD CG+ ++G+VR+GL+C      C    H RC   +  +C G R
Sbjct: 151 FCDHCGEMLFGLVRQGLKC----DGCGLNYHKRCAFSIPNNCSGAR 192


>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/76 (39%), Positives = 36/76 (47%), Gaps = 15/76 (19%)

Query: 63  TWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTN 122
           T C  C   + G+ R+GLQC     DCKF CH RC   V  DC G          E   N
Sbjct: 276 TVCQACKKLLKGLFRQGLQCK----DCKFNCHKRCATRVPNDCLG----------EALIN 321

Query: 123 VDEPVEWETPDLSQAE 138
            D P+E E  D S+A+
Sbjct: 322 GDVPME-EATDFSEAD 336



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 4/46 (8%)

Query: 64  WCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPR 109
           +CD CG+ ++G+VR+GL+C      C    H RC   +  +C G R
Sbjct: 151 FCDHCGEMLFGLVRQGLKC----DGCGLNYHKRCAFSIPNNCSGAR 192


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 27/93 (29%), Positives = 39/93 (41%), Gaps = 7/93 (7%)

Query: 13  LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
           L P  R G+G    E      +     C+   +L     H F        T+CD C  F+
Sbjct: 505 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 561

Query: 73  WGVVRKGLQCARLSADCKFTCHYRCRALVCLDC 105
           WGV ++G +C     +C   CH  CR  V ++C
Sbjct: 562 WGVTKQGYRC----RECGLCCHKHCRDQVKVEC 590


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,715,782
Number of Sequences: 37866
Number of extensions: 704469
Number of successful extensions: 2261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 2098
Number of HSP's gapped (non-prelim): 133
length of query: 344
length of database: 18,247,518
effective HSP length: 103
effective length of query: 241
effective length of database: 14,347,320
effective search space: 3457704120
effective search space used: 3457704120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.