Search of human proteins with 122056476

Search of human proteins with 122056476

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
         (538 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122056476 caspase 8 isoform G precursor [Homo sapiens]            1082   0.0  
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              964   0.0  
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             925   0.0  
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              925   0.0  
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              908   0.0  
gi|15718712 caspase 8 isoform E [Homo sapiens]                        382   e-106
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         302   6e-82
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         293   3e-79
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         240   2e-63
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    161   2e-39
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    161   2e-39
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           161   2e-39
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    159   8e-39
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    159   8e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      139   5e-33
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...   139   9e-33
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [...   139   9e-33
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      129   5e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          119   9e-27
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     102   1e-21
gi|6912286 caspase 14 precursor [Homo sapiens]                         94   4e-19
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [...    72   1e-12
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   3e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   3e-12
gi|15718702 caspase 7 isoform beta [Homo sapiens]                      70   6e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           65   2e-10
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           65   2e-10
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             65   2e-10
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              59   9e-09
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              59   9e-09

>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score = 1082 bits (2799), Expect = 0.0
 Identities = 538/538 (100%), Positives = 538/538 (100%)

Query: 1   MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM 60
           MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM
Sbjct: 1   MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM 60

Query: 61  DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 120
           DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF
Sbjct: 61  DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 120

Query: 121 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 180
           LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK
Sbjct: 121 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 180

Query: 181 FLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEF 240
           FLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEF
Sbjct: 181 FLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEF 240

Query: 241 SKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN 300
           SKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN
Sbjct: 241 SKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN 300

Query: 301 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQL 360
           HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQL
Sbjct: 301 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQL 360

Query: 361 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 420
           MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ
Sbjct: 361 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 420

Query: 421 GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY 480
           GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY
Sbjct: 421 GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY 480

Query: 481 IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
           IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 481 IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  964 bits (2491), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299
           FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240

Query: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300

Query: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360

Query: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420

Query: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225

Query: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285

Query: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345

Query: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405

Query: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225

Query: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285

Query: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345

Query: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405

Query: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  908 bits (2347), Expect = 0.0
 Identities = 464/511 (90%), Positives = 464/511 (90%), Gaps = 47/511 (9%)

Query: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 160
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY                   
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120

Query: 161 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 207
                        RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180

Query: 208 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTI 267
           RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK               GEELCGVMTI
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK---------------GEELCGVMTI 225

Query: 268 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 327
           SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG
Sbjct: 226 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 285

Query: 328 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 387
           ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG
Sbjct: 286 ALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDG 345

Query: 388 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 447
           QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSP 405

Query: 448 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 507
           QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY
Sbjct: 406 QTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNY 465

Query: 508 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538
           EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 466 EVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 496


>gi|15718712 caspase 8 isoform E [Homo sapiens]
          Length = 235

 Score =  382 bits (980), Expect = e-106
 Identities = 198/198 (100%), Positives = 198/198 (100%)

Query: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 240 FSKERSSSLEGSPDEFSN 257
           FSKERSSSLEGSPDEFSN
Sbjct: 181 FSKERSSSLEGSPDEFSN 198


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  302 bits (773), Expect = 6e-82
 Identities = 185/484 (38%), Positives = 272/484 (56%), Gaps = 35/484 (7%)

Query: 59  KMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 118
           K+ F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E + 
Sbjct: 17  KVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDP 76

Query: 119 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 178
            FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+ 
Sbjct: 77  FFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKD 133

Query: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 238
             FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I   E
Sbjct: 134 MIFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNI---E 186

Query: 239 EFSKERSSSLEGSP-----DEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRG 293
           ++ +E++  +   P     + +   EEL     +S +  +   E+     VY+M    RG
Sbjct: 187 KYKREKAIQIVTPPVDKEAESYQGEEEL-----VSQTDVKTFLEALPRAAVYRMNRNHRG 241

Query: 294 YCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYE 353
            C+I+NNH+F           S++DR GTH DA  L+  F+ L F +  H++ T  ++  
Sbjct: 242 LCVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEM 291

Query: 354 ILKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK 412
           +L+  +    H++ DCF+ CIL+HG  G +Y +D    PI E+ S FT L+CP LA KPK
Sbjct: 292 VLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPK 351

Query: 413 VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 472
           +FFIQACQG+  Q  + +E D+         L       IP EADFLLG+ATV   VS+R
Sbjct: 352 LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFR 407

Query: 473 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKK 532
           +  EG+WYIQSLC  L++  PR +DIL+ILT VN +VS + DK+   KQMPQP FTLRKK
Sbjct: 408 HVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKK 467

Query: 533 LVFP 536
           LVFP
Sbjct: 468 LVFP 471


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  293 bits (750), Expect = 3e-79
 Identities = 192/519 (36%), Positives = 271/519 (52%), Gaps = 62/519 (11%)

Query: 59  KMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 118
           K+ F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E + 
Sbjct: 17  KVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDP 76

Query: 119 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 178
            FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+ 
Sbjct: 77  FFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKD 133

Query: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 238
             FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+
Sbjct: 134 MIFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189

Query: 239 E----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMT 266
                        KE  S                LE  P E        SNG        
Sbjct: 190 REKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAP 249

Query: 267 ISDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD 318
              S   Q + + TL+         VY+M    RG C+I+NNH+F           S++D
Sbjct: 250 SLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKD 299

Query: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHG 377
           R GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG
Sbjct: 300 RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG 359

Query: 378 DKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ 437
             G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+   
Sbjct: 360 RFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNP 419

Query: 438 PYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDD 497
                 L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR +D
Sbjct: 420 EQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHED 475

Query: 498 ILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 536
           IL+ILT VN +VS + DK+   KQMPQP FTLRKKLVFP
Sbjct: 476 ILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  240 bits (613), Expect = 2e-63
 Identities = 164/477 (34%), Positives = 238/477 (49%), Gaps = 62/477 (12%)

Query: 59  KMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 118
           K+ F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E + 
Sbjct: 17  KVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDP 76

Query: 119 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 178
            FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+ 
Sbjct: 77  FFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKD 133

Query: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 238
             FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+
Sbjct: 134 MIFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189

Query: 239 E----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMT 266
                        KE  S                LE  P E        SNG        
Sbjct: 190 REKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAP 249

Query: 267 ISDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD 318
              S   Q + + TL+         VY+M    RG C+I+NNH+F           S++D
Sbjct: 250 SLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKD 299

Query: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHG 377
           R GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG
Sbjct: 300 RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG 359

Query: 378 DKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ 437
             G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+   
Sbjct: 360 RFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNP 419

Query: 438 PYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 494
                 L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR
Sbjct: 420 EQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  161 bits (407), Expect = 2e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 93  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145

Query: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 404
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204

Query: 405 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 464
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258

Query: 465 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 518
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317

Query: 519 GKQMPQPTFTLRKKLVF 535
            KQ+P     L K+L F
Sbjct: 318 KKQIPCVVSMLTKELYF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 2e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 404
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 405 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 464
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 465 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 518
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 519 GKQMPQPTFTLRKKLVF 535
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 2e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 404
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 405 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 464
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 465 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 518
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 519 GKQMPQPTFTLRKKLVF 535
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 8e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 280 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 340 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 399
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 400 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 459
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 460 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 513
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 514 DKKNMGKQMPQPTFTLRKKLVF 535
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 8e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 280 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 340 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 399
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 400 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 459
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 460 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 513
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 514 DKKNMGKQMPQPTFTLRKKLVF 535
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  139 bits (351), Expect = 5e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 282 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 341
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202

Query: 342 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 394
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262

Query: 395 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 442
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322

Query: 443 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 499
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381

Query: 500 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 535
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 9e-33
 Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)

Query: 66  LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 125
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 126 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 185
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 186 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 239
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 240 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 280
              +     ++++ S  + SN              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 281 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 340 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 396
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 397 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 454
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 511
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 512 KDDKKNMGKQMPQPTFTLRKKLV 534
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 9e-33
 Identities = 131/503 (26%), Positives = 233/503 (46%), Gaps = 66/503 (13%)

Query: 66  LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 125
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 126 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 185
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 186 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEE----- 239
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 240 ---FSKERSSSLEGSPDEFSNG-------------EELCGVMTISDSPREQDSES---QT 280
              +     ++++ S  + SN              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 281 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 340 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 396
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 397 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 454
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 511
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 512 KDDKKNMGKQMPQPTFTLRKKLV 534
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  129 bits (325), Expect = 5e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89

Query: 345 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 402
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146

Query: 403 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 454
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202

Query: 455 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 511
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261

Query: 512 ---KDDKKNMGKQMPQPTFTLRKKLVF 535
              KD      KQ+P     L KKL F
Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  119 bits (297), Expect = 9e-27
 Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y+++S+PRG  L+++N +F   +E       +  R+G  +D   L T F+ L +++    
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244

Query: 345 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 403
           D T +++ E L+ + QL  H   D  I  +LSHG +G IYG DG+   + E+   F    
Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304

Query: 404 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 457
           CPSL  KPK+FFIQAC+GD   +G+  +           + S       P+ R +P  +D
Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363

Query: 458 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 513
            + G A +    + RN   G+WYI++L Q   ER C     +  +L +VN  + +++
Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  102 bits (253), Expect = 1e-21
 Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%)

Query: 361 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 420
           + H++ DCF+C  LSHG+   IY  D +   I  LT  F G KC SL GKPK+F IQAC+
Sbjct: 17  VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75

Query: 421 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 472
           G+  Q  +PV        +T+  +    E+D +S  T  +P  ADFL+  +      S+R
Sbjct: 76  GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131

Query: 473 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 526
               G+WYIQ LC+ L  +     +   +LT VN +VS       KD      KQ+P   
Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190

Query: 527 FTLRKKLVF 535
             L KKL F
Sbjct: 191 SMLTKKLHF 199


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)

Query: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 375
           R G+  D  AL   F +L FE     D T EQ  E L+ +Q    S  D   C    +++
Sbjct: 29  REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88

Query: 376 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 435
           HG +G + G DG+   +  L        C +L  KPKV+ IQAC+G+    G  V  D  
Sbjct: 89  HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147

Query: 436 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 495
               + +   SPQT  IP   D L   +TV   ++YR+  +G+ +IQ+L     +   R 
Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199

Query: 496 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 533
             IL +LTEV   ++  +   +    K  P+   TLRK+L
Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239


>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
           [Homo sapiens]
          Length = 221

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)

Query: 66  LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 125
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 126 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 185
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 186 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 244
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173

Query: 245 SSSLEGSPDEFSN 257
             S++G+   + N
Sbjct: 174 --SVQGAGTSYRN 184



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/127 (25%), Positives = 63/127 (49%), Gaps = 9/127 (7%)

Query: 56  PFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEE 115
           P    D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++  
Sbjct: 87  PHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAP 146

Query: 116 SNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSE 175
             L  L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +  
Sbjct: 147 DQLDLLEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDP 197

Query: 176 LRSFKFL 182
             +F+ +
Sbjct: 198 SNNFRMI 204


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 301 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 359
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 360 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 416
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 417 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 455
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 456 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 513
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 514 --DKKNMGKQMPQPTFTLRKKL 533
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 301 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 359
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 360 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 416
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 417 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 455
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 456 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 513
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 514 --DKKNMGKQMPQPTFTLRKKL 533
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%)

Query: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 345 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 381
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 34  SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 82

Query: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 83  IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 142

Query: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 143 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 197

Query: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 198 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 257

Query: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
             L + ++E      D+  I  +V +     D +  M
Sbjct: 258 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 293


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 175

Query: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 176 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 235

Query: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 236 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 290

Query: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 291 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 350

Query: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
             L + ++E      D+  I  +V +     D +  M
Sbjct: 351 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 386


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)

Query: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
           S  E    + ++ ++ R    +S  +  +    S+ R   LII N  F           S
Sbjct: 106 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 154

Query: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
           I  R G  +D   +T   + L + +    + T   +   L+ +    +H   D      +
Sbjct: 155 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 214

Query: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
           SHG + GI      ++ P I +L + F  L    CPSL  KPKV  IQAC+GD+     P
Sbjct: 215 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 269

Query: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
                ++   +  +LS P T    D+A        DF+   ++  + VS+R+P  G+ +I
Sbjct: 270 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 329

Query: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
             L + ++E      D+  I  +V +     D +  M
Sbjct: 330 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 365


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 235
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 97  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 149

Query: 236 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 291
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 150 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 204

Query: 292 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 351
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 205 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254

Query: 352 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 405
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314

Query: 406 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 458
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 370

Query: 459 LLGMATVNNCVSYRNPAEGTWYIQSL 484
           +   ++  + VS+R+   G+ +I  L
Sbjct: 371 IAFCSSTPHNVSWRDRTRGSIFITEL 396


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 235
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 26  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 78

Query: 236 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 291
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 79  DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 133

Query: 292 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 351
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 134 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 183

Query: 352 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 405
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 184 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 243

Query: 406 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 458
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 244 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 299

Query: 459 LLGMATVNNCVSYRNPAEGTWYIQSL 484
           +   ++  + VS+R+   G+ +I  L
Sbjct: 300 IAFCSSTPHNVSWRDRTRGSIFITEL 325


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,950,452
Number of Sequences: 37866
Number of extensions: 990152
Number of successful extensions: 2707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 2546
Number of HSP's gapped (non-prelim): 136
length of query: 538
length of database: 18,247,518
effective HSP length: 107
effective length of query: 431
effective length of database: 14,195,856
effective search space: 6118413936
effective search space used: 6118413936
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.