Guide to the Human Genome
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Search of human proteins with 122056474

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
         (464 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             935   0.0  
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              935   0.0  
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             925   0.0  
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              925   0.0  
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              918   0.0  
gi|15718712 caspase 8 isoform E [Homo sapiens]                        353   2e-97
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         296   3e-80
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         285   5e-77
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         233   4e-61
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    161   1e-39
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    161   1e-39
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           161   1e-39
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    159   7e-39
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    159   7e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      139   4e-33
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...   134   1e-31
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [...   134   1e-31
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      129   4e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          119   8e-27
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     102   1e-21
gi|6912286 caspase 14 precursor [Homo sapiens]                         94   3e-19
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [...    73   6e-13
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   2e-12
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    71   2e-12
gi|15718702 caspase 7 isoform beta [Homo sapiens]                      70   5e-12
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           65   2e-10
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           65   2e-10
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             65   2e-10
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              56   6e-08
gi|209870073 caspase 5 isoform c [Homo sapiens]                        56   6e-08

>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  935 bits (2416), Expect = 0.0
 Identities = 464/464 (100%), Positives = 464/464 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
           FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240

Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
           SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300

Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
           SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360

Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
           EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420

Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
           GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  935 bits (2416), Expect = 0.0
 Identities = 464/464 (100%), Positives = 464/464 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240
           FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240

Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300
           SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300

Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360
           SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360

Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
           EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420

Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
           GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239

Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299

Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359

Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419

Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479

Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  925 bits (2390), Expect = 0.0
 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225
           FSK               GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
Sbjct: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240

Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285
           NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300

Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345
           LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
Sbjct: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360

Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405
           QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
Sbjct: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420

Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464
           YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Sbjct: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  918 bits (2373), Expect = 0.0
 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY                   
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120

Query: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
                        RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180

Query: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 208
           RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240

Query: 209 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 268
           KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
Sbjct: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300

Query: 269 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
           HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
Sbjct: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360

Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 388
           KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420

Query: 389 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 448
           ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
Sbjct: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480

Query: 449 PQPTFTLRKKLVFPSD 464
           PQPTFTLRKKLVFPSD
Sbjct: 481 PQPTFTLRKKLVFPSD 496


>gi|15718712 caspase 8 isoform E [Homo sapiens]
          Length = 235

 Score =  353 bits (905), Expect = 2e-97
 Identities = 183/183 (100%), Positives = 183/183 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSK 183
           FSK
Sbjct: 181 FSK 183


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  296 bits (757), Expect = 3e-80
 Identities = 185/479 (38%), Positives = 265/479 (55%), Gaps = 42/479 (8%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y  
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKY-- 188

Query: 181 FSKGEELCGVMT------ISDSPREQDSESQTLDK----------VYQMKSKPRGYCLII 224
             K E+   ++T            E++  SQT  K          VY+M    RG C+I+
Sbjct: 189 --KREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIV 246

Query: 225 NNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY 284
           NNH+F           S++DR GTH DA  L+  F+ L F +  H++ T  ++  +L+  
Sbjct: 247 NNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296

Query: 285 QLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ 343
           +    H++ DCF+ CIL+HG  G +Y +D    PI E+ S FT L+CP LA KPK+FFIQ
Sbjct: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ 356

Query: 344 ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEG 403
           ACQG+  Q  + +E D+         L       IP EADFLLG+ATV   VS+R+  EG
Sbjct: 357 ACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEG 412

Query: 404 TWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
           +WYIQSLC  L++  PR +DIL+ILT VN +VS + DK+   KQMPQP FTLRKKLVFP
Sbjct: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  285 bits (730), Expect = 5e-77
 Identities = 188/518 (36%), Positives = 270/518 (52%), Gaps = 77/518 (14%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y  
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190

Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
                          E +   EEL     V T  ++ P+E                    
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250

Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
                 Q + + TL+         VY+M    RG C+I+NNH+F           S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300

Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
            GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG 
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360

Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
            G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+    
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420

Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 424
                L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR +DI
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDI 476

Query: 425 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
           L+ILT VN +VS + DK+   KQMPQP FTLRKKLVFP
Sbjct: 477 LSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  233 bits (593), Expect = 4e-61
 Identities = 160/476 (33%), Positives = 237/476 (49%), Gaps = 77/476 (16%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y  
Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190

Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
                          E +   EEL     V T  ++ P+E                    
Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250

Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
                 Q + + TL+         VY+M    RG C+I+NNH+F           S++DR
Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300

Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
            GTH DA  L+  F+ L F +  H++ T  ++  +L+  +    H++ DCF+ CIL+HG 
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360

Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
            G +Y +D    PI E+ S FT L+CP LA KPK+FFIQACQG+  Q  + +E D+    
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420

Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
                L       IP EADFLLG+ATV   VS+R+  EG+WYIQSLC  L++  PR
Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 93  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145

Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204

Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258

Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317

Query: 445 GKQMPQPTFTLRKKLVF 461
            KQ+P     L K+L F
Sbjct: 318 KKQIPCVVSMLTKELYF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 445 GKQMPQPTFTLRKKLVF 461
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  161 bits (407), Expect = 1e-39
 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +IYG DG   PI +LT+ F G +C
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171

Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390
            +L  KPK+FFIQAC+G     GI     ++  P  + D ++P+ + IP EADFL   +T
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225

Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444
           V    S+R+P  G+W++Q+LC  L E   +  +I+ ILT VN      +E  + D   + 
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284

Query: 445 GKQMPQPTFTLRKKLVF 461
            KQ+P     L K+L F
Sbjct: 285 KKQIPCVVSMLTKELYF 301


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 7e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  159 bits (401), Expect = 7e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84

Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143

Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194

Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253

Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461
              +  KQ+P     L K+L F
Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 208 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 267
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202

Query: 268 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 320
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262

Query: 321 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 368
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322

Query: 369 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 425
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381

Query: 426 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 461
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  134 bits (338), Expect = 1e-31
 Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++  +G 
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
                                              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score =  134 bits (338), Expect = 1e-31
 Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++  +G 
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178

Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206
                                              +E  G          Q+SE+   Q+
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238

Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           + ++ Y+MKSKP G CLII+                    N T L    L  TF  L +E
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277

Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322
           ++     ++  I +IL  +  M +H + D F+C ++S G    +YG D   +  P++ + 
Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337

Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380
             F G  CP LAGKPK+FFIQ         +    +E D      +E          +  
Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397

Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437
           EADF   + T +  +  ++ +  + Y+Q L Q LR+   R   +L +  E+N   Y+ ++
Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455

Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460
           +   K   K       TLRKKL+
Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  129 bits (325), Expect = 4e-30
 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y+M  + RG  LI N+  F           ++ +R GT  D   LT  F +L FE+K  +
Sbjct: 37  YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89

Query: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328
           D   E++  +LKI+++  + H++ DCF+C  LSHG+   IY  D  +  I  LT  F G 
Sbjct: 90  DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146

Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380
           KC SL GKPK+F IQAC+G+  Q  +PV        +T+  +    E+D +S  T  +P 
Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202

Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437
            ADFL+  +      S+R    G+WYIQ LC+ L  +     +   +LT VN +VS    
Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261

Query: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461
              KD      KQ+P     L KKL F
Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  119 bits (297), Expect = 8e-27
 Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y+++S+PRG  L+++N +F   +E       +  R+G  +D   L T F+ L +++    
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244

Query: 271 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 329
           D T +++ E L+ + QL  H   D  I  +LSHG +G IYG DG+   + E+   F    
Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304

Query: 330 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 383
           CPSL  KPK+FFIQAC+GD   +G+  +           + S       P+ R +P  +D
Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363

Query: 384 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 439
            + G A +    + RN   G+WYI++L Q   ER C     +  +L +VN  + +++
Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  102 bits (253), Expect = 1e-21
 Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%)

Query: 287 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 346
           + H++ DCF+C  LSHG+   IY  D +   I  LT  F G KC SL GKPK+F IQAC+
Sbjct: 17  VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75

Query: 347 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 398
           G+  Q  +PV        +T+  +    E+D +S  T  +P  ADFL+  +      S+R
Sbjct: 76  GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131

Query: 399 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 452
               G+WYIQ LC+ L  +     +   +LT VN +VS       KD      KQ+P   
Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190

Query: 453 FTLRKKLVF 461
             L KKL F
Sbjct: 191 SMLTKKLHF 199


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)

Query: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 301
           R G+  D  AL   F +L FE     D T EQ  E L+ +Q    S  D   C    +++
Sbjct: 29  REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88

Query: 302 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 361
           HG +G + G DG+   +  L        C +L  KPKV+ IQAC+G+    G  V  D  
Sbjct: 89  HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147

Query: 362 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 421
               + +   SPQT  IP   D L   +TV   ++YR+  +G+ +IQ+L     +   R 
Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199

Query: 422 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 459
             IL +LTEV   ++  +   +    K  P+   TLRK+L
Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239


>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
           [Homo sapiens]
          Length = 221

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/179 (27%), Positives = 98/179 (54%), Gaps = 8/179 (4%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG 184
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++  +G
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQG 177



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 32/122 (26%), Positives = 62/122 (50%), Gaps = 9/122 (7%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++    L  
Sbjct: 92  DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151

Query: 62  LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
           L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +    +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202

Query: 122 FL 123
            +
Sbjct: 203 MI 204


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 440 --DKKNMGKQMPQPTFTLRKKL 459
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%)

Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285
           ++ +KAR  +  L  I+ R G   D  AL      L FE     D T +   E L  + +
Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233

Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342
            +D     + C +  +++HG  +G + G DGQE     L  + +  +C  L G+PK+F +
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291

Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381
           QAC+G N   G+              P    S     Q Y E   SS   R  P    D+
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349

Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439
           AD L   +     V+YR+  +G+ +IQ+L + LR     G D+L +LTEVN  V  ++  
Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406

Query: 440 --DKKNMGKQMPQPTFTLRKKL 459
             D   + K   +   +LR++L
Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%)

Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
           Y M  +  G C+IINN NF        K+  +  RNGT  DA AL   F  L F++  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112

Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 307
           DC+  ++ ++LK     DH+N  CF C +LSHG++ +
Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)

Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
           KS      LII N  F           SI  R G  +D   +T   + L + +    + T
Sbjct: 65  KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114

Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
              +   L+ +    +H   D      +SHG + GI      ++ P I +L + F  L  
Sbjct: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174

Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
             CPSL  KPKV  IQAC+GD+     P     ++   +  +LS P T    D+A     
Sbjct: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229

Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
              DF+   ++  + VS+R+P  G+ +I  L + ++E      D+  I  +V +     D
Sbjct: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288

Query: 440 DKKNM 444
            +  M
Sbjct: 289 GRAQM 293


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)

Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
           KS      LII N  F           SI  R G  +D   +T   + L + +    + T
Sbjct: 158 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207

Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
              +   L+ +    +H   D      +SHG + GI      ++ P I +L + F  L  
Sbjct: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267

Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
             CPSL  KPKV  IQAC+GD+     P     ++   +  +LS P T    D+A     
Sbjct: 268 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 322

Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
              DF+   ++  + VS+R+P  G+ +I  L + ++E      D+  I  +V +     D
Sbjct: 323 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 381

Query: 440 DKKNM 444
            +  M
Sbjct: 382 GRAQM 386


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)

Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
           KS      LII N  F           SI  R G  +D   +T   + L + +    + T
Sbjct: 137 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186

Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
              +   L+ +    +H   D      +SHG + GI      ++ P I +L + F  L  
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246

Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
             CPSL  KPKV  IQAC+GD+     P     ++   +  +LS P T    D+A     
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 301

Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
              DF+   ++  + VS+R+P  G+ +I  L + ++E      D+  I  +V +     D
Sbjct: 302 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 360

Query: 440 DKKNM 444
            +  M
Sbjct: 361 GRAQM 365


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)

Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           D++Y +K +   R   LII N  F    + +P       RNG H D   +    + L + 
Sbjct: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242

Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
           +    + T   +  +L+ +    +H + D     ++SHG    I GT  ++      +Y+
Sbjct: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302

Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
              Q F    C SL  KPKV  +QAC+G+     + +  P       S+    LE D   
Sbjct: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359

Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
                I +E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)

Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
           D++Y +K +   R   LII N  F    + +P       RNG H D   +    + L + 
Sbjct: 38  DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 87

Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
           +    + T   +  +L+ +    +H + D     ++SHG    I GT  ++      +Y+
Sbjct: 88  VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 147

Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
              Q F    C SL  KPKV  +QAC+G+     + +  P       S+    LE D   
Sbjct: 148 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 204

Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
                I +E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 205 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,653,513
Number of Sequences: 37866
Number of extensions: 823947
Number of successful extensions: 2242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 2090
Number of HSP's gapped (non-prelim): 103
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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