BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|122056474 caspase 8 isoform C precursor [Homo sapiens] (464 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 935 0.0 gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 935 0.0 gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 925 0.0 gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 925 0.0 gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 918 0.0 gi|15718712 caspase 8 isoform E [Homo sapiens] 353 2e-97 gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 296 3e-80 gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 285 5e-77 gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 233 4e-61 gi|15718698 caspase 7 isoform delta [Homo sapiens] 161 1e-39 gi|15718700 caspase 7 isoform alpha [Homo sapiens] 161 1e-39 gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 161 1e-39 gi|14790115 caspase 3 preproprotein [Homo sapiens] 159 7e-39 gi|14790119 caspase 3 preproprotein [Homo sapiens] 159 7e-39 gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 139 4e-33 gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 134 1e-31 gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 134 1e-31 gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 129 4e-30 gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 119 8e-27 gi|14916485 caspase 6 isoform beta [Homo sapiens] 102 1e-21 gi|6912286 caspase 14 precursor [Homo sapiens] 94 3e-19 gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [... 73 6e-13 gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 2e-12 gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 71 2e-12 gi|15718702 caspase 7 isoform beta [Homo sapiens] 70 5e-12 gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 65 2e-10 gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 65 2e-10 gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 65 2e-10 gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 56 6e-08 gi|209870073 caspase 5 isoform c [Homo sapiens] 56 6e-08 >gi|122056474 caspase 8 isoform C precursor [Homo sapiens] Length = 464 Score = 935 bits (2416), Expect = 0.0 Identities = 464/464 (100%), Positives = 464/464 (100%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240 Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300 Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360 Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420 Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 >gi|15718708 caspase 8 isoform C precursor [Homo sapiens] Length = 464 Score = 935 bits (2416), Expect = 0.0 Identities = 464/464 (100%), Positives = 464/464 (100%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 Query: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH Sbjct: 181 FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 240 Query: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL Sbjct: 241 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL 300 Query: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS Sbjct: 301 SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS 360 Query: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR Sbjct: 361 EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420 Query: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD Sbjct: 421 GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 >gi|122056476 caspase 8 isoform G precursor [Homo sapiens] Length = 538 Score = 925 bits (2390), Expect = 0.0 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE Sbjct: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239 Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225 FSK GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN Sbjct: 240 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 299 Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ Sbjct: 300 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 359 Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC Sbjct: 360 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 419 Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW Sbjct: 420 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 479 Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD Sbjct: 480 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 538 >gi|15718706 caspase 8 isoform B precursor [Homo sapiens] Length = 479 Score = 925 bits (2390), Expect = 0.0 Identities = 464/479 (96%), Positives = 464/479 (96%), Gaps = 15/479 (3%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 Query: 181 FSK---------------GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 225 FSK GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN Sbjct: 181 FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN 240 Query: 226 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 285 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ Sbjct: 241 NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ 300 Query: 286 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 345 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC Sbjct: 301 LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC 360 Query: 346 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 405 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW Sbjct: 361 QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 420 Query: 406 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 464 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD Sbjct: 421 YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 479 >gi|15718704 caspase 8 isoform A precursor [Homo sapiens] Length = 496 Score = 918 bits (2373), Expect = 0.0 Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120 Query: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148 RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180 Query: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 208 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLD 240 Query: 209 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 268 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP Sbjct: 241 KVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP 300 Query: 269 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL Sbjct: 301 HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 360 Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 388 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM Sbjct: 361 KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM 420 Query: 389 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 448 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM Sbjct: 421 ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM 480 Query: 449 PQPTFTLRKKLVFPSD 464 PQPTFTLRKKLVFPSD Sbjct: 481 PQPTFTLRKKLVFPSD 496 >gi|15718712 caspase 8 isoform E [Homo sapiens] Length = 235 Score = 353 bits (905), Expect = 2e-97 Identities = 183/183 (100%), Positives = 183/183 (100%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 Query: 181 FSK 183 FSK Sbjct: 181 FSK 183 >gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] Length = 479 Score = 296 bits (757), Expect = 3e-80 Identities = 185/479 (38%), Positives = 265/479 (55%), Gaps = 42/479 (8%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 + F L I L +D+ +LKFL + +P +K E A +F+ L + +L E + Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+ Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180 FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKY-- 188 Query: 181 FSKGEELCGVMT------ISDSPREQDSESQTLDK----------VYQMKSKPRGYCLII 224 K E+ ++T E++ SQT K VY+M RG C+I+ Sbjct: 189 --KREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIV 246 Query: 225 NNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY 284 NNH+F S++DR GTH DA L+ F+ L F + H++ T ++ +L+ Sbjct: 247 NNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296 Query: 285 QLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ 343 + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK+FFIQ Sbjct: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ 356 Query: 344 ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEG 403 ACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R+ EG Sbjct: 357 ACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEG 412 Query: 404 TWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462 +WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP Sbjct: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471 >gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] Length = 522 Score = 285 bits (730), Expect = 5e-77 Identities = 188/518 (36%), Positives = 270/518 (52%), Gaps = 77/518 (14%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 + F L I L +D+ +LKFL + +P +K E A +F+ L + +L E + Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+ Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178 FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190 Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199 E + EEL V T ++ P+E Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250 Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245 Q + + TL+ VY+M RG C+I+NNH+F S++DR Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300 Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304 GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360 Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364 G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+ Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420 Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 424 L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR +DI Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDI 476 Query: 425 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462 L+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP Sbjct: 477 LSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514 >gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] Length = 521 Score = 233 bits (593), Expect = 4e-61 Identities = 160/476 (33%), Positives = 237/476 (49%), Gaps = 77/476 (16%) Query: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60 + F L I L +D+ +LKFL + +P +K E A +F+ L + +L E + Sbjct: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77 Query: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120 FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+ Sbjct: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134 Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178 FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y Sbjct: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190 Query: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199 E + EEL V T ++ P+E Sbjct: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250 Query: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245 Q + + TL+ VY+M RG C+I+NNH+F S++DR Sbjct: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300 Query: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304 GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360 Query: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364 G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+ Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420 Query: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420 L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR Sbjct: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472 >gi|15718698 caspase 7 isoform delta [Homo sapiens] Length = 336 Score = 161 bits (407), Expect = 1e-39 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++ Sbjct: 93 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 145 Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330 DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C Sbjct: 146 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 204 Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390 +L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 258 Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444 V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D + Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 317 Query: 445 GKQMPQPTFTLRKKLVF 461 KQ+P L K+L F Sbjct: 318 KKQIPCVVSMLTKELYF 334 >gi|15718700 caspase 7 isoform alpha [Homo sapiens] Length = 303 Score = 161 bits (407), Expect = 1e-39 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++ Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112 Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330 DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171 Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390 +L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225 Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444 V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D + Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284 Query: 445 GKQMPQPTFTLRKKLVF 461 KQ+P L K+L F Sbjct: 285 KKQIPCVVSMLTKELYF 301 >gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] Length = 303 Score = 161 bits (407), Expect = 1e-39 Identities = 98/257 (38%), Positives = 144/257 (56%), Gaps = 21/257 (8%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++ Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112 Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKC 330 DC+ ++ ++LK DH+N CF C +LSHG++ +IYG DG PI +LT+ F G +C Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRC 171 Query: 331 PSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMAT 390 +L KPK+FFIQAC+G GI ++ P + D ++P+ + IP EADFL +T Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGI----QADSGPINDTD-ANPRYK-IPVEADFLFAYST 225 Query: 391 VNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN------YEVSNKDDKKNM 444 V S+R+P G+W++Q+LC L E + +I+ ILT VN +E + D + Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEH-GKDLEIMQILTRVNDRVARHFESQSDDPHFHE 284 Query: 445 GKQMPQPTFTLRKKLVF 461 KQ+P L K+L F Sbjct: 285 KKQIPCVVSMLTKELYF 301 >gi|14790115 caspase 3 preproprotein [Homo sapiens] Length = 277 Score = 159 bits (401), Expect = 7e-39 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%) Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 +LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84 Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325 ++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143 Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385 G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194 Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439 +T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253 Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461 + KQ+P L K+L F Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275 >gi|14790119 caspase 3 preproprotein [Homo sapiens] Length = 277 Score = 159 bits (401), Expect = 7e-39 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%) Query: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 +LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E Sbjct: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84 Query: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325 ++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F Sbjct: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143 Query: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385 G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL Sbjct: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194 Query: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439 +T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D Sbjct: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253 Query: 440 DKKNMGKQMPQPTFTLRKKLVF 461 + KQ+P L K+L F Sbjct: 254 ATFHAKKQIPCIVSMLTKELYF 275 >gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] Length = 416 Score = 139 bits (351), Expect = 4e-33 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%) Query: 208 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 267 D Y + +P G+CLIINN NF + +R R G+++D L F LHF ++ Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202 Query: 268 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 320 D T +++ L DH +DC + ILSHG + G +YGTDG + + Sbjct: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262 Query: 321 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 368 + + F G CPSL GKPK+FFIQAC G+ G V + S E P+ E Sbjct: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322 Query: 369 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 425 + Q I P +D + +T VS+R+P G+WY+++L + E+ +D+ Sbjct: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381 Query: 426 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 461 ++L V+N K + KQMP LRKKL F Sbjct: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413 >gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] Length = 480 Score = 134 bits (338), Expect = 1e-31 Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%) Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66 ++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59 Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126 +R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++ Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118 Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184 + + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178 Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206 +E G Q+SE+ Q+ Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238 Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 + ++ Y+MKSKP G CLII+ N T L L TF L +E Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277 Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322 ++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ + Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337 Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380 F G CP LAGKPK+FFIQ + +E D +E + Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397 Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437 EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++ Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455 Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460 + K K TLRKKL+ Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476 >gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] Length = 480 Score = 134 bits (338), Expect = 1e-31 Identities = 129/503 (25%), Positives = 226/503 (44%), Gaps = 81/503 (16%) Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66 ++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59 Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126 +R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++ Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118 Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG- 184 + + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178 Query: 185 -----------------------------------EELCGVMTISDSPREQDSES---QT 206 +E G Q+SE+ Q+ Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238 Query: 207 L-DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 + ++ Y+MKSKP G CLII+ N T L L TF L +E Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------------NETEL----LRDTFTSLGYE 277 Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEA--PIYELT 322 ++ ++ I +IL + M +H + D F+C ++S G +YG D + P++ + Sbjct: 278 VQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIR 337 Query: 323 SQFTGLKCPSLAGKPKVFFIQ--ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPD 380 F G CP LAGKPK+FFIQ + +E D +E + Sbjct: 338 RMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHR 397 Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVN---YEVSN 437 EADF + T + + ++ + + Y+Q L Q LR+ R +L + E+N Y+ ++ Sbjct: 398 EADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQE--RKRPLLDLHIELNGYMYDWNS 455 Query: 438 KDDKKNMGKQMPQPTFTLRKKLV 460 + K K TLRKKL+ Sbjct: 456 RVSAKE--KYYVWLQHTLRKKLI 476 >gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] Length = 293 Score = 129 bits (325), Expect = 4e-30 Identities = 94/267 (35%), Positives = 135/267 (50%), Gaps = 31/267 (11%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y+M + RG LI N+ F ++ +R GT D LT F +L FE+K + Sbjct: 37 YKMDHRRRGIALIFNHERFFWHL-------TLPERRGTCADRDNLTRRFSDLGFEVKCFN 89 Query: 271 DCTVEQIYEILKIYQL--MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL 328 D E++ +LKI+++ + H++ DCF+C LSHG+ IY D + I LT F G Sbjct: 90 DLKAEEL--LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGD 146 Query: 329 KCPSLAGKPKVFFIQACQGDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPD 380 KC SL GKPK+F IQAC+G+ Q +PV +T+ + E+D +S T +P Sbjct: 147 KCHSLVGKPKIFIIQACRGN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPA 202 Query: 381 EADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN--- 437 ADFL+ + S+R G+WYIQ LC+ L + + +LT VN +VS Sbjct: 203 GADFLMCYSVAEGYYSHRETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRV 261 Query: 438 ---KDDKKNMGKQMPQPTFTLRKKLVF 461 KD KQ+P L KKL F Sbjct: 262 DFCKDPSAIGKKQVPCFASMLTKKLHF 288 >gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] Length = 452 Score = 119 bits (297), Expect = 8e-27 Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++ Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244 Query: 271 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 329 D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F Sbjct: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304 Query: 330 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 383 CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D Sbjct: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363 Query: 384 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 439 + G A + + RN G+WYI++L Q ER C + +L +VN + +++ Sbjct: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418 >gi|14916485 caspase 6 isoform beta [Homo sapiens] Length = 204 Score = 102 bits (253), Expect = 1e-21 Identities = 70/189 (37%), Positives = 96/189 (50%), Gaps = 20/189 (10%) Query: 287 MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ 346 + H++ DCF+C LSHG+ IY D + I LT F G KC SL GKPK+F IQAC+ Sbjct: 17 VSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACR 75 Query: 347 GDNYQKGIPV--------ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 398 G+ Q +PV +T+ + E+D +S T +P ADFL+ + S+R Sbjct: 76 GN--QHDVPVIPLDVVDNQTEKLDTNITEVDAASVYT--LPAGADFLMCYSVAEGYYSHR 131 Query: 399 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSN------KDDKKNMGKQMPQPT 452 G+WYIQ LC+ L + + +LT VN +VS KD KQ+P Sbjct: 132 ETVNGSWYIQDLCEML-GKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFA 190 Query: 453 FTLRKKLVF 461 L KKL F Sbjct: 191 SMLTKKLHF 199 >gi|6912286 caspase 14 precursor [Homo sapiens] Length = 242 Score = 93.6 bits (231), Expect = 3e-19 Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%) Query: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 301 R G+ D AL F +L FE D T EQ E L+ +Q S D C +++ Sbjct: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88 Query: 302 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 361 HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D Sbjct: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147 Query: 362 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 421 + + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R Sbjct: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199 Query: 422 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 459 IL +LTEV ++ + + K P+ TLRK+L Sbjct: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239 >gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [Homo sapiens] Length = 221 Score = 72.8 bits (177), Expect = 6e-13 Identities = 49/179 (27%), Positives = 98/179 (54%), Gaps = 8/179 (4%) Query: 7 LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66 ++ + E LD+++ L FL D ++D L + L+E+ L +L+ ELL Sbjct: 6 IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59 Query: 67 FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126 +R+ R DLL L ++ +E L +S YRV++ +I E++ +S++ S FL+++ Sbjct: 60 YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118 Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKG 184 + + K+ + + LD+ +E+EK ++ +LD+L++ I++ LK I Y++ +G Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQG 177 Score = 45.8 bits (107), Expect = 8e-05 Identities = 32/122 (26%), Positives = 62/122 (50%), Gaps = 9/122 (7%) Query: 2 DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61 D+ + +IGE LD D++SL FL DY+ + K K L L L++ ++ L Sbjct: 92 DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151 Query: 62 LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121 L++ L I+R+D L T+ ++ ++ +Q G ++YR +L ++ + +F+ Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202 Query: 122 FL 123 + Sbjct: 203 MI 204 >gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sapiens] Length = 432 Score = 70.9 bits (172), Expect = 2e-12 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%) Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285 ++ +KAR + L I+ R G D AL L FE D T + E L + + Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233 Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342 +D + C + +++HG +G + G DGQE L + + +C L G+PK+F + Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291 Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381 QAC+G N G+ P S Q Y E SS R P D+ Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349 Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439 AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++ Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406 Query: 440 --DKKNMGKQMPQPTFTLRKKL 459 D + K + +LR++L Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428 >gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sapiens] Length = 432 Score = 70.9 bits (172), Expect = 2e-12 Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%) Query: 227 HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-Q 285 ++ +KAR + L I+ R G D AL L FE D T + E L + + Sbjct: 175 YDLSKARAAL-LLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233 Query: 286 LMD--HSNMDCFICCILSHGD-KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI 342 +D + C + +++HG +G + G DGQE L + + +C L G+PK+F + Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291 Query: 343 QACQGDNYQKGI--------------PVETDSEE---QPYLEMDLSSPQTRYIP----DE 381 QAC+G N G+ P S Q Y E SS R P D+ Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSS--CRGTPPGSSDQ 349 Query: 382 ADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD-- 439 AD L + V+YR+ +G+ +IQ+L + LR G D+L +LTEVN V ++ Sbjct: 350 ADILTVYSAAEGYVAYRDD-KGSDFIQTLVEVLRAN--PGRDLLELLTEVNRRVCEQEVL 406 Query: 440 --DKKNMGKQMPQPTFTLRKKL 459 D + K + +LR++L Sbjct: 407 GPDCDELRKACLEIRSSLRRRL 428 >gi|15718702 caspase 7 isoform beta [Homo sapiens] Length = 253 Score = 69.7 bits (169), Expect = 5e-12 Identities = 36/97 (37%), Positives = 54/97 (55%), Gaps = 7/97 (7%) Query: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270 Y M + G C+IINN NF K+ + RNGT DA AL F L F++ ++ Sbjct: 60 YNMNFEKLGKCIIINNKNF-------DKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYN 112 Query: 271 DCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI 307 DC+ ++ ++LK DH+N CF C +LSHG++ + Sbjct: 113 DCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENM 149 >gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] Length = 311 Score = 64.7 bits (156), Expect = 2e-10 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%) Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273 KS LII N F SI R G +D +T + L + + + T Sbjct: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114 Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329 + L+ + +H D +SHG + GI ++ P I +L + F L Sbjct: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174 Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382 CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A Sbjct: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229 Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439 DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D Sbjct: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288 Query: 440 DKKNM 444 + M Sbjct: 289 GRAQM 293 >gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] Length = 404 Score = 64.7 bits (156), Expect = 2e-10 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%) Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273 KS LII N F SI R G +D +T + L + + + T Sbjct: 158 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207 Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329 + L+ + +H D +SHG + GI ++ P I +L + F L Sbjct: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267 Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382 CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A Sbjct: 268 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 322 Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439 DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D Sbjct: 323 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 381 Query: 440 DKKNM 444 + M Sbjct: 382 GRAQM 386 >gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] Length = 383 Score = 64.7 bits (156), Expect = 2e-10 Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%) Query: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273 KS LII N F SI R G +D +T + L + + + T Sbjct: 137 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186 Query: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329 + L+ + +H D +SHG + GI ++ P I +L + F L Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246 Query: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382 CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A Sbjct: 247 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 301 Query: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439 DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D Sbjct: 302 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 360 Query: 440 DKKNM 444 + M Sbjct: 361 GRAQM 365 >gi|209870079 caspase 5 isoform f precursor [Homo sapiens] Length = 447 Score = 56.2 bits (134), Expect = 6e-08 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%) Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 D++Y +K + R LII N F + +P RNG H D + + L + Sbjct: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242 Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320 + + T + +L+ + +H + D ++SHG I GT ++ +Y+ Sbjct: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302 Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372 Q F C SL KPKV +QAC+G+ + + P S+ LE D Sbjct: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359 Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410 I +E DF+ ++ + VS+R+ G+ +I L Sbjct: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396 >gi|209870073 caspase 5 isoform c [Homo sapiens] Length = 292 Score = 56.2 bits (134), Expect = 6e-08 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%) Query: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265 D++Y +K + R LII N F + +P RNG H D + + L + Sbjct: 38 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 87 Query: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320 + + T + +L+ + +H + D ++SHG I GT ++ +Y+ Sbjct: 88 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 147 Query: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372 Q F C SL KPKV +QAC+G+ + + P S+ LE D Sbjct: 148 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 204 Query: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410 I +E DF+ ++ + VS+R+ G+ +I L Sbjct: 205 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 241 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.137 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,653,513 Number of Sequences: 37866 Number of extensions: 823947 Number of successful extensions: 2242 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 42 Number of HSP's successfully gapped in prelim test: 37 Number of HSP's that attempted gapping in prelim test: 2090 Number of HSP's gapped (non-prelim): 103 length of query: 464 length of database: 18,247,518 effective HSP length: 106 effective length of query: 358 effective length of database: 14,233,722 effective search space: 5095672476 effective search space used: 5095672476 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.