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Search of human proteins with 120953300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120953300 leucine-rich repeats and IQ motif containing 1
isoform 1 [Homo sapiens]
(1722 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 3445 0.0
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 2672 0.0
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 113 1e-24
gi|148746195 trichohyalin [Homo sapiens] 113 1e-24
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 110 1e-23
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 108 3e-23
gi|221219020 NYD-SP11 protein [Homo sapiens] 99 3e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 96 4e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 92 6e-18
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 90 2e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 89 4e-17
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 89 5e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 89 5e-17
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 89 5e-17
gi|71061468 centromere protein E [Homo sapiens] 88 6e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 2e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 86 2e-16
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 86 4e-16
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 86 4e-16
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 86 4e-16
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 86 4e-16
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 86 4e-16
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 85 7e-16
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 83 3e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 83 3e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 82 3e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 82 3e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 82 3e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 82 3e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 82 4e-15
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 3445 bits (8934), Expect = 0.0
Identities = 1722/1722 (100%), Positives = 1722/1722 (100%)
Query: 1 MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII 60
MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII
Sbjct: 1 MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII 60
Query: 61 KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE 120
KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE
Sbjct: 61 KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE 120
Query: 121 EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE 180
EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE
Sbjct: 121 EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE 180
Query: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE 240
LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE
Sbjct: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE 240
Query: 241 KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY 300
KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY
Sbjct: 241 KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY 300
Query: 301 QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR 360
QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR
Sbjct: 301 QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR 360
Query: 361 EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG 420
EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG
Sbjct: 361 EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG 420
Query: 421 DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM 480
DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM
Sbjct: 421 DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM 480
Query: 481 EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI 540
EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI
Sbjct: 481 EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI 540
Query: 541 MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK 600
MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK
Sbjct: 541 MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK 600
Query: 601 DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT 660
DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT
Sbjct: 601 DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT 660
Query: 661 TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP 720
TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP
Sbjct: 661 TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP 720
Query: 721 EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA 780
EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA
Sbjct: 721 EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA 780
Query: 781 LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK 840
LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK
Sbjct: 781 LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK 840
Query: 841 KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY 900
KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY
Sbjct: 841 KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY 900
Query: 901 SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY 960
SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY
Sbjct: 901 SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY 960
Query: 961 WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL 1020
WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL
Sbjct: 961 WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL 1020
Query: 1021 QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF 1080
QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF
Sbjct: 1021 QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF 1080
Query: 1081 VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN
Sbjct: 1081 VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
Query: 1141 GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY 1200
GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY
Sbjct: 1141 GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY 1200
Query: 1201 FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS 1260
FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS
Sbjct: 1201 FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS 1260
Query: 1261 PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT 1320
PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT
Sbjct: 1261 PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT 1320
Query: 1321 NSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQTIL 1380
NSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQTIL
Sbjct: 1321 NSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQTIL 1380
Query: 1381 KKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFI 1440
KKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFI
Sbjct: 1381 KKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFI 1440
Query: 1441 FDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDK 1500
FDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDK
Sbjct: 1441 FDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDK 1500
Query: 1501 ENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKR 1560
ENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKR
Sbjct: 1501 ENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKR 1560
Query: 1561 AQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPIHKDTTA 1620
AQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPIHKDTTA
Sbjct: 1561 AQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPIHKDTTA 1620
Query: 1621 NEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGRVQLVARLVSRED 1680
NEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGRVQLVARLVSRED
Sbjct: 1621 NEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGRVQLVARLVSRED 1680
Query: 1681 TDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI 1722
TDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI
Sbjct: 1681 TDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI 1722
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 2672 bits (6926), Expect = 0.0
Identities = 1335/1336 (99%), Positives = 1336/1336 (100%)
Query: 1 MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII 60
MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII
Sbjct: 1 MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINII 60
Query: 61 KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE 120
KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE
Sbjct: 61 KNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKE 120
Query: 121 EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE 180
EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE
Sbjct: 121 EFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE 180
Query: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE 240
LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE
Sbjct: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE 240
Query: 241 KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY 300
KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY
Sbjct: 241 KIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAY 300
Query: 301 QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR 360
QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR
Sbjct: 301 QKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRR 360
Query: 361 EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG 420
EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG
Sbjct: 361 EKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKG 420
Query: 421 DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM 480
DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM
Sbjct: 421 DIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKM 480
Query: 481 EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI 540
EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI
Sbjct: 481 EEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKI 540
Query: 541 MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK 600
MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK
Sbjct: 541 MKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYK 600
Query: 601 DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT 660
DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT
Sbjct: 601 DKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNT 660
Query: 661 TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP 720
TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP
Sbjct: 661 TDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAP 720
Query: 721 EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA 780
EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA
Sbjct: 721 EPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPA 780
Query: 781 LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK 840
LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK
Sbjct: 781 LDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCK 840
Query: 841 KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY 900
KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY
Sbjct: 841 KLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGY 900
Query: 901 SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY 960
SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY
Sbjct: 901 SFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLY 960
Query: 961 WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL 1020
WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL
Sbjct: 961 WNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKL 1020
Query: 1021 QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF 1080
QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF
Sbjct: 1021 QGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHF 1080
Query: 1081 VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN
Sbjct: 1081 VSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
Query: 1141 GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY 1200
GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY
Sbjct: 1141 GNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHY 1200
Query: 1201 FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS 1260
FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS
Sbjct: 1201 FKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDS 1260
Query: 1261 PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT 1320
PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT
Sbjct: 1261 PDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT 1320
Query: 1321 NSLLRNHQNIEPSEKI 1336
NSLLRNHQNIEPSEK+
Sbjct: 1321 NSLLRNHQNIEPSEKM 1336
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 113 bits (283), Expect = 1e-24
Identities = 108/487 (22%), Positives = 245/487 (50%), Gaps = 62/487 (12%)
Query: 169 QSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE 228
+ + W+EK +E E+K ++ + R++EEK ++EE W K+ K+ +++ +K+E
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM---WEKEEKMRRQEEMMWEKEE 363
Query: 229 QDKMNDELY--KEEKIWK--EKFKQHEEYIRNLHLQM-EEERTRFKDQQEKEKNSLLKQQ 283
+ + +E+ KEEK+ + E + EE IR L +M E+E+ R ++++ +E+ + +Q+
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 284 NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE---NRKRLE 340
+EQ R+ ++ +E+E KIR++E++ +++
Sbjct: 424 KR----------------------QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461
Query: 341 EEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILRED---ASQQLIIS 397
E+++I+EE K+Q++EE R+E++ E++ I +Q+ + +EKI +E+ ++ I
Sbjct: 462 EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIRE 521
Query: 398 SALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTIL 457
K K E+ ++ ++ + E K E +W EE +E D+
Sbjct: 522 QEEKIREQEEKMWRQEEKIREQEEMWR----EEEKMHEQEKIW--EEEKRQEQEDKMWRQ 575
Query: 458 KESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDL 517
+E I+ + +E + Q + K+ E+ E ++ E++ KQE K + K + +
Sbjct: 576 EEKIR-EQEEKVWRQ----EEKIREQEEK--RQEQEEKMWKQEEKIREQEEKIQEQEEKI 628
Query: 518 KGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKD 577
+ +++ ++E + Q++E+ M + Q+ ++ QE E +E+KI
Sbjct: 629 R---EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM-----QEQEETMWRQEEKI--R 678
Query: 578 NQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYS 637
Q+KKI++ ++E+I+EQ ++ + ++ + ++ + E ++ E + QE++++
Sbjct: 679 EQEKKIRE-QEEKIREQEEMMQEQEEKM--WEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 735
Query: 638 KSKEIEE 644
+ + +
Sbjct: 736 QEVRLRQ 742
Score = 105 bits (261), Expect = 5e-22
Identities = 93/397 (23%), Positives = 207/397 (52%), Gaps = 66/397 (16%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEK-----RHCWMKQFKV-- 216
+EK R+ E QE++K E +++Q +A+ R+E++ +E+EEK + W ++ K+
Sbjct: 403 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 217 EKKKLENIQKQEQDKM---NDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQE 273
++K E ++QEQ++M ++++++E+IW++K K HE+ + ++ +EE+ ++++
Sbjct: 463 QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK---IRKQEEKVWRQEEKI 519
Query: 274 KEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQ---IESKKRKAQE---WKEKEAK 327
+E+ +++Q + + K + + + EQ E +KR+ QE W+++E K
Sbjct: 520 REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE-K 578
Query: 328 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 387
IR++EE+ ++ E+ + +E+R++Q+E+ K+ EK E+++ I +QE + +EKI +
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ 638
Query: 388 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQE-DVLLWLVEESN 446
E+ +Q+ G+ + + ++ K QE + +W EE
Sbjct: 639 EEMTQEQ---------------------EEKMGEQEEKMCEQEEKMQEQEETMWRQEE-- 675
Query: 447 MKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENT 506
K + I ++ +++ +E + M+E+ E + ++ E++ +QE K +
Sbjct: 676 -KIREQEKKIREQEEKIREQEEM----------MQEQEEKMWEQ--EEKMCEQEEKMQEQ 722
Query: 507 DNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKH 543
+ K +E+ QE++ Q+EEK+ +H
Sbjct: 723 EEKMR--------RQEEKMWEQEVRL-RQQEEKMQEH 750
Score = 90.9 bits (224), Expect = 1e-17
Identities = 108/508 (21%), Positives = 237/508 (46%), Gaps = 58/508 (11%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Q K+LE + + + D K E E+ Q K + +E + K E+D ++
Sbjct: 150 QHAVKQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTK-ERDALSL 207
Query: 235 ELYK----EEKIWKEKFKQHEEY-------------IRNLHLQMEEERTRFKDQQ-EKEK 276
ELY+ +E++ ++ K E+ ++ L ++E + QQ + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK----EAKIRQKE 332
+ L K+ + + K+QA+ + + + +E++ ++ K QEW+EK E KIR++E
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 333 EENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQ 392
E+ R++ EE+ R +EE +KEE+ +R+E+ EK+ ++++ E + KE+ + R+ +
Sbjct: 328 EKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ---E 383
Query: 393 QLIISSALKKSGYNNKHLSLEDI--SNDKGDIAKNLVDENSKKQEDVLLWLVEES--NMK 448
+++ K K E I +K + + ++ +++++ +W EE +
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443
Query: 449 ENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD- 507
E + Q E + +E I Q EK K++ EE+ +QE K +
Sbjct: 444 EKIREQ----EKKMWRQEEKIHEQ---------EKIREEEKRQEQEEMWRQEEKIHEQEE 490
Query: 508 ---NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEIS 564
K ++ + K +E+ ++ + ++EEKI + + Q+ +I
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQE-EKMWRQEEKIREQEEMWRE 549
Query: 565 EVKTNEEQKIIKDNQQKKIQKV---EKEEIQEQNGLLYKDKDTLVISVKQR-----SLSL 616
E K +E++KI ++ ++++ + ++E+I+EQ +++ ++ + ++R +
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609
Query: 617 TSENSKDVRENVILQEKEIYSKSKEIEE 644
E ++ E + QE++I + ++I E
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEEKIRE 637
Score = 45.8 bits (107), Expect = 4e-04
Identities = 29/95 (30%), Positives = 62/95 (65%), Gaps = 9/95 (9%)
Query: 161 CEVEEKCRQSFEA-WQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK 219
CE EEK ++ E W++++K E ++K + ++ RE+++ +E+E++ W ++ K+ ++
Sbjct: 657 CEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK-MWEQEEKMCEQ 715
Query: 220 KLENIQKQEQDKMNDELYKEEKIWKE--KFKQHEE 252
+ E +Q+QE +KM + EEK+W++ + +Q EE
Sbjct: 716 E-EKMQEQE-EKMRRQ---EEKMWEQEVRLRQQEE 745
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 113 bits (283), Expect = 1e-24
Identities = 112/517 (21%), Positives = 249/517 (48%), Gaps = 63/517 (12%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQ---RDREEKQFQEEEEKRHCWMKQFKVEKKK 220
EE+ R+ F WQ + +E ++ +Q L A+ R++ E+Q + EE ++ + E+K+
Sbjct: 760 EEEQRRDF-TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 221 LENIQKQEQDKMNDELYKEEKIWK-EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL 279
Q++E++K L +EE++ + E+ +Q +E L E R++ + + +K + L
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 280 LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRL 339
+++ + AK +K +++E+ E +R+ +E + ++ + RQ EE + +
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 340 EEEQRIKEERKKQKEEERKR---------------------------REKEYEEKKNIVK 372
EEEQ ++EER+K++ +ER+R REK+Y E++ + +
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL-Q 997
Query: 373 QEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKN----LVD 428
QE EQL+ +E RE +Q KK + L +K + + +
Sbjct: 998 QEEEQLLREE----REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 429 ENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLA 488
E +++E+ LL E+ ++ ++RQ +E +Q + ++ + + E++
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP-------EKRRRQER 1106
Query: 489 KKRC-SEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINE 547
+++C EE ++QE + + + + +L+ +E+ +Q Q+EE++++ +
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ------QEEEQLLREEPEK 1160
Query: 548 NTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVI 607
Q+ + +E+ + EE++++++ Q+K+ Q+ E++ +E+ K K
Sbjct: 1161 RRRQELERQYREEEELQQ----EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216
Query: 608 SVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEE 644
++ L E K EN + ++ ++Y K +E E+
Sbjct: 1217 EDQRSDLKWQWEPEK---ENAV-RDNKVYCKGRENEQ 1249
Score = 110 bits (274), Expect = 2e-23
Identities = 111/506 (21%), Positives = 238/506 (47%), Gaps = 49/506 (9%)
Query: 162 EVEEKCRQSFEAWQEKQ--KELEDK--EKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVE 217
E ++ R+ E W+++Q +E E++ E++ L++ + E ++F +EE+ R + + + +
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221
Query: 218 KKKLENIQKQE-QDKMNDELYKEEKIWK---------EKFKQHEEYIRNLHLQMEEERTR 267
++ + Q++E QD++ E +EEK W+ E+ Q EE R LQ EEE+ R
Sbjct: 222 GREEKQQQRRERQDRVFQE--EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 268 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327
++QE + ++Q ++ + + + ++Q E ++ + +E +E++ +
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLR------------RKQEEERREQQEERREQQER 327
Query: 328 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRRE----KEYEEKKNIVKQEREQLISKEK 383
Q+EE ++L EQ + E++ ++E+E +RRE +E EE++ + REQ + +E+
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 384 IILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVE 443
+ RE QQL L++ + L + + E + ++ E
Sbjct: 388 QLRRE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 444 ESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKY 503
+ +E +R+ LK + + E + L + EE+ E K E +QER+
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 504 ENTDNKTELGNSD-LKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQE 562
+ + E LK +E+ Q L+S+ Q + ++ + +L +E
Sbjct: 505 QQLRREQEERREQRLKRQEEEERLQQRLRSEQQ---------LRREQEERREQLLKREEE 555
Query: 563 ISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLS-LTSENS 621
+ EQ++ ++ ++++ Q +++EE + Q L + ++ L +K+ + L E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 622 KD---VRENVILQEKEIYSKSKEIEE 644
++ RE + ++ KS+E EE
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEE 641
Score = 105 bits (261), Expect = 5e-22
Identities = 108/505 (21%), Positives = 246/505 (48%), Gaps = 72/505 (14%)
Query: 163 VEEKCRQSFEAWQEKQKELEDKEKQTLKAQRD----REEKQFQEEEEKRHCWMKQFKVEK 218
++E+ R+ + QE+++EL+ +E++ + Q REE+Q Q+EEE+ +++ + ++
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ---LLREEREKR 951
Query: 219 KKLENIQKQEQDK----MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
++ E ++ +DK ++L EE + + ++ ++Y LQ EEE+ ++++EK
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL-LREEREK 1010
Query: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
+ ++Q ++Q + + + ++ ++E+ E + R+ +E +++E ++ +E E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQQEEEQLLGEERE 1069
Query: 335 NRKR--------------LEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLIS 380
R+R EEEQ ++EE +K++ +ER+R+ +E EE ++QE EQL+
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE----LQQEEEQLLR 1125
Query: 381 KEK-IILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLL 439
+E+ R++ +Q +++ + L E + ++ + +E +QE+ L
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQE--EEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 440 WLVEESNMKENVDRQTILKESIQ-VKLKESISSQTILADFK--MEEKNENLA---KKRCS 493
E+ ++ +RQ +E +Q K K+ + +D K E + EN K C
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 494 EELVKQERKYENTDNKTELGNSDLKGNLKEQ------------------FPLQE-LKSDA 534
+Q R+ E++ + DL+ L EQ FP +E L+ +
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 535 QKEEKIM-------KHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE 587
QKE K K ++ E +K ++ ++ K EE++++++ +++ +++ E
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEK------RRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 588 KEEIQEQNGLLYKDKDTLVISVKQR 612
++ + L ++++ + +QR
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQR 1382
Score = 103 bits (256), Expect = 2e-21
Identities = 86/467 (18%), Positives = 226/467 (48%), Gaps = 28/467 (5%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
+++E+ Q QE++++L E+Q L+ +R EE+Q Q ++ KQ + +++
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 222 ENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLK 281
E ++Q++ + E +E+++ +E+ ++ E+ +R + E+ ++Q+E+ + L+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 282 QQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEE 341
++ + Q + + + ++ ++ ++ + ++ +E ++R+++EE R +
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 342 EQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALK 401
EQ +E+R K+++EER+ K EE + ++ R+Q + +++ E + L + +
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ--EEERRERWLKLEEEER 496
Query: 402 KSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESI 461
+ + L ++ + +E + Q+ L ++ ++ R+ +LK
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQ--RLRSEQQLRREQEERREQLLKREE 554
Query: 462 QVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNL 521
+ +L++ Q + + EE+ + L K+ EE +Q K E + L+ L
Sbjct: 555 EKRLEQERREQRLKRE--QEERRDQLLKR--EEERRQQRLKREQEER--------LEQRL 602
Query: 522 KEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQK 581
K + ++ L+ + ++E+++ + E ++ Q++ QE +Q++ ++ Q++
Sbjct: 603 KRE-EVERLEQEERREQRLKREEPEEE--RRQQLLKSEEQE-----ERRQQQLRREQQER 654
Query: 582 KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENV 628
+ Q++++EE +E+ K + ++R L E + RE +
Sbjct: 655 REQRLKREEEEERLEQRLKREH----EEERREQELAEEEQEQARERI 697
Score = 103 bits (256), Expect = 2e-21
Identities = 114/584 (19%), Positives = 267/584 (45%), Gaps = 60/584 (10%)
Query: 102 EYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYC 161
E +E EQL K+ E++E R + + E L ++ + +
Sbjct: 270 ELQEEEEQLRKL----ERQELRRERQE-------EEQQQQRLRREQQLRRKQEE------ 312
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQF--QEEEEKRHCWMKQFKVEKK 219
E E+ + E + ++++ E +E+Q + Q +R E+Q ++EEE+R +++ + E++
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 220 KLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRN---------------LHLQMEEE 264
+ + +++++Q + +L +E+++ +E+ + E+ +R L + EEE
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 265 RTRFKDQQEKEKNSLLKQQNNAA--VKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWK 322
R K +QE+ + L ++Q +K + + + ++ + ++Q E ++ + + +
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 323 EKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEER----------KRREKEYEEKKNIVK 372
E+E + +Q+ E + R E+E+R ++ K+Q+EEER RRE+E E ++ ++K
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE-ERREQLLK 551
Query: 373 QEREQLISKEKIILREDASQQLIISSALKK-SGYNNKHLSLEDISNDKGDIAKNLVD--E 429
+E E+ + +E+ R Q+ LK+ + L E + + + V+ E
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 430 NSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAK 489
+++E L E ++ + + +E Q +L+ + K EE+ E L +
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKREEEEERL-E 669
Query: 490 KRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENT 549
+R E ++ R+ E + + E +K + + E ++DA++ + + E
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 550 GQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQK-----VEKEEIQEQNGLLYKDKDT 604
++ + + SE++ EE++ + Q+++ ++ + EE E+ +
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Query: 605 LVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKD 648
L +QR L +E + + + +E+E + ++ E K+
Sbjct: 790 L---REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Score = 95.1 bits (235), Expect = 5e-19
Identities = 89/494 (18%), Positives = 246/494 (49%), Gaps = 35/494 (7%)
Query: 161 CEVEEKCRQSFEAWQEKQKELEDKEKQTLK--AQRDREEKQFQEEEEKRHCWMKQFKVEK 218
C+ +E Q +E Q+ E +++Q + QR R+++Q QE E + + + +
Sbjct: 103 CDGKESLLQD-RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE------LAEGEEQS 155
Query: 219 KKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNS 278
+K E ++++++ + ++EL+++ + W+E+ ++ E L E F D+++ +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE-EQLQSCKGHETEEFPDEEQLRRRE 214
Query: 279 LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQE-WKEKEAKIRQKEEENRK 337
LL+ + + Q + + ++ + +E+ E + RK + +++E K++++E + ++
Sbjct: 215 LLELRRKGREEKQQQRR-----ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 338 RLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIIS 397
L+EE+ ++ RK +++E R+ R++E ++++ + REQ + +++ R + ++
Sbjct: 270 ELQEEE--EQLRKLERQELRRERQEEEQQQQRL---RREQQLRRKQEEERREQQEERREQ 324
Query: 398 SALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTIL 457
++ + L ++ + + ++ +++E L EE ++ + R+ L
Sbjct: 325 QERREQQEERREQQLRREQEERRE-QQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 458 KESIQVKLKESISSQTILADFKMEEKNENLAKKR--CSEELVKQERKYENTDNKTELGNS 515
+ Q++ ++ + + L + + + L +++ E+ +++E++ E + K E
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 516 DLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISE--VKTNEEQK 573
+ + LK + +E + ++EE+ +H E +K Q+ +E E +K EE++
Sbjct: 444 EQR--LKRE--QEERRDWLKREEETERH---EQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 574 IIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEK 633
++ Q+++ Q++ +E+ + + L + ++ + + RS ++ RE ++ +E+
Sbjct: 497 --REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 634 EIYSKSKEIEENPK 647
E + + E+ K
Sbjct: 555 EKRLEQERREQRLK 568
Score = 95.1 bits (235), Expect = 5e-19
Identities = 131/604 (21%), Positives = 277/604 (45%), Gaps = 109/604 (18%)
Query: 102 EYEESSEQLIKILSEI----------EKEEFMRSKTDCATPDFVPEPSPHDL-----PMD 146
E ++ EQL++ E E+EE R K D E DL P
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD---EDQRSDLKWQWEPEK 1231
Query: 147 EHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDRE----EKQFQE 202
E+ + D N YC+ E E+ ++LED + + ++Q+D + E+Q ++
Sbjct: 1232 ENAVRD----NKVYCKGREN---------EQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278
Query: 203 EEEKRHCWMKQFK--VEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQ 260
E++R W ++ + E+++LE ++Q++ K D +EEK + L +
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLER-EEQKEAKRRDRKSQEEK-------------QLLREE 1324
Query: 261 MEEERTRFK-DQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQ 319
EE+R R + D++ +E+ LL+++ ++ Q + + F +E+ + + +
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF----------REEELRHQEQGR 1374
Query: 320 EWKEKEAKIRQKEEENRKRLEEEQRIK-EERKKQ--KEEERKRREKEY------------ 364
++ E+E ++R++E E RK L+EEQ+++ +ER++Q ++ +RK RE+E
Sbjct: 1375 KFLEEEQRLRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 365 EEKKNIVKQEREQLISKEKIILRED------ASQQLI---ISSALKKSGYNNKHLSLEDI 415
EE++ + +QERE+ +E+ LR++ +QL+ L + + K L E+
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE-EEQ 1492
Query: 416 SNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL 475
+ + + ++ + QE +L EE + ++ L+E Q++ +E +
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 476 ADFKMEEKNENLAKKRCSEELVKQE--RKYENTDNKTELGNSDLK-----GNLKEQFPLQ 528
D K E+ E L ++R ++L +QE RK+ + K + K L+ Q Q
Sbjct: 1553 RDRKFREE-EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 529 ELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEK 588
+L+ + ++ + + ++ E Q+ H QE EE ++ + ++++++
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQL-----HRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 589 EEIQEQNGLLYKDKDTLV--------ISVKQRSLSLTSENSKDVRENVILQEKEIYSKSK 640
+ +E+ LL + ++ + +++ L K ++E L+ +E+ K +
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR 1726
Query: 641 EIEE 644
E E+
Sbjct: 1727 EEEQ 1730
Score = 88.6 bits (218), Expect = 5e-17
Identities = 94/491 (19%), Positives = 230/491 (46%), Gaps = 37/491 (7%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE---QDK 231
QE+ ++ ++E+Q + +R+R K +EE++ R ++F+ E++ L+ ++Q+ Q++
Sbjct: 1426 QERDRKFREEEQQVRRQERER--KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 232 MNDELYKEEKIWKE----KFKQHEEYIRNLHLQMEEERTRFKDQQEKEK----NSLLKQQ 283
L +E+++ ++ KF++ E + + EE + QQ + K L++Q
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 284 NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQ 343
+ Q + + F ++ +EQ S++ + ++++ +E K+R++E+E RK +E+EQ
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE-RKFMEDEQ 1602
Query: 344 RIKEERKKQ---KEEERKRREKEY----EEKKNIVKQEREQLISKEKIILREDASQQLII 396
+++ + +Q +E +RK RE E E++ + +QER++ +E+ LR +Q +
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 397 SSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTI 456
+K ++ + + ++ ++QE + EE ++ +
Sbjct: 1663 HDRDRK-------------FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 457 LKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQER-KYENTDNKTELGNS 515
L+E Q++ +E + E + E L ++ +++++E+ + E + +
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Query: 516 DLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQ-KTQIILGHNQEISEVKTNEEQKI 574
D K +EQ + + + +E K E Q + + L Q + + EEQ
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 575 IKDNQQKKIQKVEKE-EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEK 633
+++ +Q+ Q+ +++ +EQ K + ++ E + +RE I +++
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 634 EIYSKSKEIEE 644
+ + +++ E
Sbjct: 1890 KEEQRHRQVGE 1900
Score = 79.0 bits (193), Expect = 4e-14
Identities = 81/384 (21%), Positives = 184/384 (47%), Gaps = 61/384 (15%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEK-QTLKAQRDREEKQFQEEEE--KRHCWMKQFKVEK-K 219
EE+ RQ E Q ++E + K + + K +R +E++F E+E+ +R +Q + E+ +
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 220 KLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHL--QMEEERTR-FKDQ----Q 272
K ++ Q++ +L+++E+ KF + E +R Q+ +R R F+++ Q
Sbjct: 1620 KFREDEQLLQEREEQQLHRQER--DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 273 EKEKNSLLKQQNNAA-------VKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKE 325
E E+ L +Q+ + ++ Q + + F+ Q+ + ++++E K R+ ++ +++
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFL--QEEQQLRRQELERKFREEEQLRQET 1735
Query: 326 AKIRQKEEENRKRLEEEQRIKEERKKQ----KEEERKRREKEY----EEKKNIVKQEREQ 377
+ + + +E +++ EE++++ ER++Q +E +RK RE+E E++ + QE ++
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 378 LISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDV 437
+E+ + +E QQL K + + L LE+
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE----------------------- 1832
Query: 438 LLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELV 497
+E +++ DRQ +E + K Q + + + + + E K R EE +
Sbjct: 1833 -----QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR--EEHI 1885
Query: 498 KQERKYENTDNKT-ELGNSDLKGN 520
++++K E + E+ + + KG+
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQEGKGH 1909
Score = 67.4 bits (163), Expect = 1e-10
Identities = 63/287 (21%), Positives = 142/287 (49%), Gaps = 25/287 (8%)
Query: 112 KILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSF 171
++L E E+++ R + D F+ E E L D D F EE+ Q
Sbjct: 1626 QLLQEREEQQLHRQERD---RKFLEEEPQLRRQEREQQLRHDRDRKF---REEEQLLQEG 1679
Query: 172 EAWQEKQKELEDK---EKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE 228
E Q +++E + K E+Q L+ Q +RE K QEE++ R +++ E+++L +QE
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 229 QDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQ--QEKEKNSLLKQQNNA 286
Q + + + KI +E+ + E + L Q + + R ++Q QE+E+ L Q+++
Sbjct: 1739 QLRRQE---RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 287 AVKIQAKYKAFVAYQKYGPIIKE----------QIESKKRKAQEWKEKEAKIRQKEEENR 336
+ + + + Q+ P ++ Q+E ++++ ++ ++++ + ++
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 337 KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEK 383
K EEQ + +E ++++ +ER+R+ +E ++ +++R + + + K
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIK 1902
Score = 34.7 bits (78), Expect = 0.82
Identities = 30/135 (22%), Positives = 59/135 (43%), Gaps = 15/135 (11%)
Query: 1507 EHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQ-----QMLKRA 1561
E Q RSE + E + R+ LLK E+EK++ +E + + Q Q+LKR
Sbjct: 526 ERLQQRLRSEQQLRR---EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 1562 QKMKSKKLKKKIDSTVRLAL-------FKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPI 1614
++ + ++LK++ + + L + E + K + + RR + E++
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 1615 HKDTTANEKLERNRE 1629
+ E+ ER +
Sbjct: 643 RQQQLRREQQERREQ 657
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 110 bits (275), Expect = 1e-23
Identities = 118/583 (20%), Positives = 278/583 (47%), Gaps = 73/583 (12%)
Query: 172 EAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK-KLENIQKQEQD 230
E W++++ EL ++EK+ R +EEK +++EE R K + E+K + + + +EQ+
Sbjct: 235 EMWRQEE-ELREQEKKI----RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289
Query: 231 KMNDELYKEEKIWKE--KFKQHEEYIRNLHLQMEEERTRFKDQQEK---EKNSLLKQQNN 285
K EL ++EK +E K ++ EE ++ +M E+ + ++Q+EK ++ L +Q+
Sbjct: 290 K---ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 286 AAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEE--ENRKRLEEEQ 343
+ Q +++Q E + + +EKE ++R++E+ E ++++EE+
Sbjct: 347 MREQEQK--------------MRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392
Query: 344 RIKEERKKQKEEE---RKRREKEYEEKKNIVKQE----REQLISKEKIILREDASQQLII 396
RI+E KK +EEE R++ EK ++++N+ +QE ++Q + ++K L E Q
Sbjct: 393 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ--- 449
Query: 397 SSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTI 456
++ + + D G K E ++QED +W +E M++ +
Sbjct: 450 ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED-QMW-EQEEKMRDQEQKMWD 504
Query: 457 LKESIQVKLKESISSQTILADFKMEEKNENLAKKR---CSEELVKQERKYENTDNKTELG 513
+E + + D ++ EK E + +++ EE +++E+K + + KT
Sbjct: 505 QEERMWEQ------------DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT--- 549
Query: 514 NSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQE---ISEVKTNE 570
D + ++E+ ++E + ++EE++M+ E Q+ + + +E E K E
Sbjct: 550 -WDQEEKMREEERMREREKKMREEEEMMRE--QEEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 571 EQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVIL 630
+++ + + ++K ++ E++++QEQ ++++ ++ + ++ + E ++ E +
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM--QEQEEKMWEQEEKMREQEEKMRE 664
Query: 631 QEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKR-NDQDYVLGRHAPCEGLSN 689
QE+++ + +++ E ++ + + M E K ++ + G+ G
Sbjct: 665 QEEKMQGQEEKMREQ-EEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723
Query: 690 YNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSES 732
+ + + ++ + E+C E P + C +S +
Sbjct: 724 MREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHT 766
Score = 84.3 bits (207), Expect = 9e-16
Identities = 79/344 (22%), Positives = 168/344 (48%), Gaps = 47/344 (13%)
Query: 162 EVEEKCRQSFE-AWQEKQKEL------EDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQF 214
E EEK ++ E W++++KE E KEK + + +E++ E+EEK + +
Sbjct: 410 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 469
Query: 215 KVEKK--KLENIQKQE------QDKMNDELYKEEKIW--KEKFKQHEEYIRNLHLQMEEE 264
EKK + E +++QE ++KM D+ E+K+W +E+ + +E +R +M E+
Sbjct: 470 GQEKKMWRQEKMREQEDQMWEQEEKMRDQ---EQKMWDQEERMWEQDERLREKEERMREQ 526
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
+ ++ +++ + ++Q + K + ++ ++E+ E + + ++ +E+
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 586
Query: 325 EAKIRQKE----EENRKRLEEEQRIKEERKK--QKEEERKRREKE---YEEKKNIVKQER 375
E K+R++E E+ K E+E+++ E+ +K ++EEE K +E+E +E+++ + +QE
Sbjct: 587 EEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEE 646
Query: 376 EQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQE 435
+ +EK+ +E+ ++ K G K E+ +G K E + +
Sbjct: 647 KMWEQEEKMREQEEKMRE----QEEKMQGQEEKMREQEE--KMQGQEEKMREQEEKMRGQ 700
Query: 436 DVLLWLVEE------------SNMKENVDRQTILKESIQVKLKE 467
+ +W EE M+E +R KE +Q +L E
Sbjct: 701 EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
Score = 75.1 bits (183), Expect = 5e-13
Identities = 89/440 (20%), Positives = 210/440 (47%), Gaps = 33/440 (7%)
Query: 215 KVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
K + +E + K E+D ++ ELY+ +E K++ E L L E E++ + K
Sbjct: 155 KKADRYIEELTK-ERDALSLELYRNTITNEELKKKNAELQEKLRLA-ESEKSEIQ-LNVK 211
Query: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
E L++ ++Q +++ + +++ + +K++ + W+++E ++R++E +
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-RLREQEGK 270
Query: 335 NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQL 394
R++ EE+ R +E+R +++E+E + +EKE E+K + +QE + +EK+ +E+ ++
Sbjct: 271 MREQ-EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 395 IISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQ 454
++ + + + D + + +++ + +E +E M+E ++
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE-------KEERMRE---QE 379
Query: 455 TILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNK--TEL 512
+ ++ +++ +E I + + KM E+ E + ++ E++ KQE + K +
Sbjct: 380 KMWEQEEKMQEEERIRER----EKKMREEEETMREQ--EEKMQKQEENMWEQEEKEWQQQ 433
Query: 513 GNSDLKGNLKEQFPLQELKSDA-QKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEE 571
+ K L EQ +QE + ++EEKI E GQ+ ++ E + E+
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ--EEMWGQEKKMWRQEKMREQEDQMWEQ 491
Query: 572 QKIIKDNQQKKIQKVEK-----EEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDV-- 624
++ ++D +QK + E+ E ++E+ + + K K R T E K
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 625 RENVILQEKEIYSKSKEIEE 644
+E + +E+ + + K++ E
Sbjct: 552 QEEKMREEERMREREKKMRE 571
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 108 bits (271), Expect = 3e-23
Identities = 138/649 (21%), Positives = 301/649 (46%), Gaps = 84/649 (12%)
Query: 20 SISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELILQDLEDTD 79
++S++ ++D E + + D S+EL + + + K ++ E+L L + E ++
Sbjct: 184 ALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSE 243
Query: 80 ILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPS 139
I ++++ L + E + L ++ + +EE R + + +
Sbjct: 244 I-----------QLNVKE-LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 291
Query: 140 PHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRD-REEK 198
+ E L E E K R+ E ++K L ++EK+ + +++ RE+K
Sbjct: 292 EEKMWRQEERLR----------EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341
Query: 199 QFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLH 258
+ +E+EE Q + +++K+ ++++KM ++ EEK+W++ EE +
Sbjct: 342 ELREQEE-------QMQEQEEKM----WEQEEKMREQ---EEKMWRQ-----EERLWEQE 382
Query: 259 LQMEEERTRFKDQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKR 316
QM E+ + +DQ+E+ E++ L+++ +++ + K + +K K Q + KK
Sbjct: 383 KQMREQEQKMRDQEERMWEQDERLREKEE---RMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 317 KAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQERE 376
+ QE K +E + R +E E + R EEE ++E K QK+EE ++E E ++ + +++E
Sbjct: 440 RDQEEKMQEEE-RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 498
Query: 377 QLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQED 436
+L +EK+ +E+ + + + D G K E ++QED
Sbjct: 499 KLWEQEKMQEQEEKIWE--------------QEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 437 VLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEK---NENLAKKRCS 493
+W +E M++ + +E ++ K +E +T + KM E+ E K R
Sbjct: 545 -QMW-EQEEKMRDQEQKMWDQEERMEKKTQEQ-EKKTWDQEEKMREEERMREREKKMREE 601
Query: 494 EELVK-QERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKE---EKIMKHVINENT 549
EE+++ QE K + + K + + +E+ QE K Q+E E+ K +
Sbjct: 602 EEMMREQEEKMQEQEEKMQ-EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 550 GQKTQIILGHN--QEISEVKTNEEQKIIKDNQQKKIQKVEK-----EEIQEQNGLLYKDK 602
++ + + H QE +++ EE+ ++ +KK Q+ EK E+++E+ + ++K
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 603 DTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAW 651
+ ++ + E ++ E + QE+E++ + +++ E ++ W
Sbjct: 721 K---MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ-EEKMW 765
Score = 99.0 bits (245), Expect = 4e-20
Identities = 119/528 (22%), Positives = 255/528 (48%), Gaps = 74/528 (14%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEK-QFQEEEEKRHCWMKQFKVEKKKLE 222
EE RQ E ++++K + +EK + +R RE++ + +E+EEK K+ + ++K+L
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Query: 223 NIQKQ--------EQDKMNDELYKEEKIWK---------EKFKQHEEYIRNLHLQMEEER 265
+K+ EQ++ E +EEK+W+ EK + EE + QM E+
Sbjct: 332 EQEKELREQKELREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 266 TRFKDQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWK- 322
+ +DQ+E+ E++ L+++ +++ + K + +K K Q + KK + QE K
Sbjct: 390 QKMRDQEERMWEQDERLREKEE---RMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 323 -------EKEAKIRQKEEENRKRLE----EEQRIKEERKKQKEEER--KRREKEYEEKKN 369
E+E K+R++EE R++ E +E+ + E+ +K+ +++R +++EK +E++K
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK- 505
Query: 370 IVKQEREQLI--SKEKIILREDA--------SQQLIISSALKKSGYNNKHLSLEDISNDK 419
QE+E+ I +EKI +E+ Q+ + + K E D+
Sbjct: 506 --MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563
Query: 420 GDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFK 479
+ + E KK D + EE M+E +++ +E + + +E + Q + K
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMRER-EKKMREEEEMMREQEEKMQEQ----EEK 618
Query: 480 MEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEK 539
M+E+ E + ++ E++ +QE K + K + + + EQ L E K + EK
Sbjct: 619 MQEQEEKMWEQ--EEKMQEQEEKMWEQEEKM----WEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 540 IMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLY 599
+ + + +K QE E KT E++K D ++ + E+E ++E+ +
Sbjct: 673 MQEQEKMQEQEEKI-----WEQEKMEKKTQEQEKKTWDQEKMR----EEESMREREKKMR 723
Query: 600 KDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPK 647
++++ ++ ++ + E ++ E + QE++++ + +++ E +
Sbjct: 724 EEEE--MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Score = 98.6 bits (244), Expect = 5e-20
Identities = 111/507 (21%), Positives = 245/507 (48%), Gaps = 49/507 (9%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTL-KAQRDREEKQFQEEE----------EKRHCW 210
E EE+ R+ + W++ +K E+K+ Q K RD+EEK QEEE E+
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM-QEEERIREREKKMREEEETM 466
Query: 211 MKQFKVEKKKLENIQKQEQDKMNDELYKE--EKIW-KEKFKQHEEYIRNLHLQMEEERTR 267
+Q + +K+ EN+ +QE+ + + E EK+W +EK ++ EE I ++ ++
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 268 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWK--EKE 325
+ +++ + +++Q + + + K + Q+ +E+ KK + QE K ++E
Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRD----QEQKMWDQEERMEKKTQEQEKKTWDQE 582
Query: 326 AKIRQKE---EENRKRLEEEQRIKEERKKQKEEERKRREKE---YEEKKNIVKQEREQLI 379
K+R++E E +K EEE+ ++E+ +K +E+E K +E+E +E+++ + +QE +
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 380 SKEKIILREDAS-QQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVL 438
+EK+ +E+ +Q + +K + K E + + I + E ++++
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK 702
Query: 439 LWLVEESNMKENV-DRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELV 497
W E+ +E++ +R+ ++E ++ ++ + KM+E+ E + ++ EE+
Sbjct: 703 TWDQEKMREEESMREREKKMREEEEMMREQ---------EEKMQEQEEKMQEQ--EEEMW 751
Query: 498 KQERKYENTDNK--TELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQI 555
+QE K + K + + K L E +QE + ++EEK M+ + GQ+ ++
Sbjct: 752 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK-MRDQEEKMRGQEEKM 810
Query: 556 ILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLS 615
E K +++ + ++K + EK QE+ ++K + ++ +
Sbjct: 811 ------RGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMR 864
Query: 616 LTSENSKDVRENVILQEKEIYSKSKEI 642
E + E + QE+++ + ++I
Sbjct: 865 EQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 71.6 bits (174), Expect = 6e-12
Identities = 104/487 (21%), Positives = 207/487 (42%), Gaps = 61/487 (12%)
Query: 235 ELYKEEKIWKEKFKQHEEYIRNLH-----LQMEEERTRFKDQQEKEKNSLLKQQ----NN 285
EL + + K+ + YI L L +E R +++ K+KN+ L+++ +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 286 AAVKIQAKYKAFVAYQKYGPIIKEQIESKK------RKAQEWKEKEAKIRQKEEENRKRL 339
+IQ K + + Q+++ R+ +E +E+E KIR K+EE R
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR-KQEEKMWRQ 298
Query: 340 EEEQR--------------IKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKI- 384
EE R +E+R +++E+E + +EKE E+K + +QE + +EK+
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 385 ----ILREDASQQLIISSAL--KKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVL 438
+RE + L ++ + + D + + L ++ + +E
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 439 LW-----LVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCS 493
+W + EE M+E + +E +Q +E I + + KM E+ E + ++
Sbjct: 419 MWEQVEKMREEKKMQEQEKKTRDQEEKMQE--EERIRER----EKKMREEEETMREQ--E 470
Query: 494 EELVKQERKYENTDNK--TELGNSDLKGNLKEQFPLQELKSDA-QKEEKIMKHVINENTG 550
E++ KQE + K + + K L EQ +QE + ++EEKI E G
Sbjct: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ--EEMWG 528
Query: 551 QKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVK 610
Q+ ++ E + E+++ ++D +QK + E+ E + Q ++K T K
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE----QEKKTWDQEEK 584
Query: 611 QRSLSLTSENSKDVR--ENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIE 668
R E K +R E ++ +++E + +E + ++ W + + M E
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 669 GKRNDQD 675
K +Q+
Sbjct: 645 EKMWEQE 651
Score = 68.9 bits (167), Expect = 4e-11
Identities = 54/222 (24%), Positives = 114/222 (51%), Gaps = 23/222 (10%)
Query: 162 EVEEKCRQSFEAWQEK--QKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK 219
E E+ Q + W+++ +K+ +++EK+T ++ REE+ +E E+K + + +++
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 220 KLENIQKQEQDKMNDELYKEEKIW---------------KEKFKQHEEYIRNLHLQMEEE 264
K++ +++ Q++ + +EEK+W KEK +HE+ + +EE
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQK-YGPIIKEQIESKKRKAQEWKE 323
+ R DQ+EK + K + + K + +K +G +E++ ++ K +E
Sbjct: 795 KMR--DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ--EEKMWGQEEKMWGQEE 850
Query: 324 KEAKIRQKEEENRKRLEEEQRIKEERKKQKEEE-RKRREKEY 364
K + Q +EE + EE+ R +EE+ +++EE+ R + EK Y
Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 99.4 bits (246), Expect = 3e-20
Identities = 114/521 (21%), Positives = 253/521 (48%), Gaps = 55/521 (10%)
Query: 162 EVEEKCRQSFEAWQEK-QKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKK 220
+V + R+S++AW+E+ +K L +E++ +A ++ +E+K+ W + +V +
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENM 1528
Query: 221 LENIQKQEQDKMNDELYKEEKIWKE------KFKQHEEYIRNLH--LQMEEERTRFKDQQ 272
L + K++Q K +E+ EE++ +E + + + +I+ H ++ +R R + ++
Sbjct: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKR 1588
Query: 273 EKEKNSLLKQQNNAAVK----IQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKI 328
+E+ L +++ A + Q + K AY K +E +++ + AQ+ + +
Sbjct: 1589 AQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRG 1648
Query: 329 RQKEEENRKRLEEEQRIKEERKKQKEEERKRREK--EYEEKKNIVKQEREQLISKEKIIL 386
+ +E K ++ +++ ++ +K EE K +K + E KNI+ Q+ E+L +E+ +
Sbjct: 1649 EKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL- 1707
Query: 387 REDASQQLIISSALKKSGYNNKHLSL--EDISNDKGDIAKNLVDENSK--KQEDVLLWLV 442
Q+ ++ L++ ++ + LS E+++ ++G LV+E K ++E+ L W
Sbjct: 1708 ---DWQEKELAQELEELEWDMEELSWKEEELNQEEG----KLVEEKKKLAEEEEALAWQR 1760
Query: 443 EESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKR--CSEELVKQE 500
E+ + +E Q +E + ++ KE ++ KM E+ E L +KR E+ +K
Sbjct: 1761 EKLSEEETKLAQ---EEELLIQEKEKLAQH----KEKMPEEEERLGRKREQLIEKKMKLA 1813
Query: 501 RKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVIN------ENTGQKTQ 554
+K E N E + +++ QE K+ AQ++EK+ + N T K Q
Sbjct: 1814 QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873
Query: 555 IILGHNQ---------EISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTL 605
++ N+ ++ E T E++ +IK +++K+ + EK+ +Q ++ L K +
Sbjct: 1874 LVQVKNKLGMFNKILAQVEEKLTQEKETVIK--KKEKLAETEKKLVQVEDSLAKKQEKLA 1931
Query: 606 VISVKQRSLSLTSENSKDVRE--NVILQEKEIYSKSKEIEE 644
+K + K +R ++ +EK + + K + E
Sbjct: 1932 QEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAE 1972
Score = 83.2 bits (204), Expect = 2e-15
Identities = 116/541 (21%), Positives = 241/541 (44%), Gaps = 102/541 (18%)
Query: 143 LPMDEHVLPDDADINFGYCEVEEKCRQSFE---AWQEKQKELEDKEKQTLKAQ--RDREE 197
L +E +L +D + + E+ +Q +E + + K+++ +D+E+ TL+ + R+ EE
Sbjct: 1503 LSPEEEMLQEDKKLKW------EEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE 1556
Query: 198 KQFQEEEEKRHC-----WM----KQFKVEKKKLENIQK--QEQDKMNDELYKEEKIWKEK 246
K+ Q EE+RH W K+ + EKK+ + +K QE++K+ E E ++ +E+
Sbjct: 1557 KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE---ERQLAQEE 1613
Query: 247 FKQHEEYIR------------NLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKY 294
K + Y++ Q EE + ++ +E L +++ A K +
Sbjct: 1614 RKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA 1673
Query: 295 KAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKE 354
+ K G + E +K +E ++E + +E+E + LEE + EE ++E
Sbjct: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEE 1733
Query: 355 EERKRREKEYEEKKNIVKQE------REQLISKEKIILRED------------------- 389
E + K EEKK + ++E RE+L +E + +E+
Sbjct: 1734 ELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPE 1793
Query: 390 ------ASQQLIISSALKKSGYNNKHL-SLEDISNDKGDI--AKNLVDENSKKQEDVLLW 440
++ +I +K + + + S+E+++ +K + KNL E ++
Sbjct: 1794 EEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKL 1853
Query: 441 LVEESNMKENVDRQT-ILKESIQVKLKESISSQTIL-ADFKMEEKNENLAKKR------- 491
+ N+ N +R T K+ +QVK K + ++ + + K+ ++ E + KK+
Sbjct: 1854 AQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETE 1913
Query: 492 -----CSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVIN 546
+ L K++ K K L + ++G + + L D KEEK + +
Sbjct: 1914 KKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-----DIAKEEKALNLEMK 1968
Query: 547 ENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQ-----EQNGLLYKD 601
+K +++ G + +S+ +T E ++Q+K+ +VE+E + E+ LL++D
Sbjct: 1969 RLAEEKMRLVEG-KETLSKGETPE------TSRQRKMTQVEQELFERKLSLEEKILLHED 2021
Query: 602 K 602
+
Sbjct: 2022 R 2022
Score = 73.9 bits (180), Expect = 1e-12
Identities = 95/479 (19%), Positives = 207/479 (43%), Gaps = 55/479 (11%)
Query: 162 EVEEKCRQSFEAWQEKQKEL-EDKEKQTLKA------QRDREEKQFQEEEEKRHCWMKQF 214
E E+K Q ++ +KQ++L ++K K L+ +R R E +EE+ + MK+
Sbjct: 1911 ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRL 1970
Query: 215 KVEKKKL-------------ENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQM 261
EK +L E ++++ ++ EL++ + +EK HE+ I L M
Sbjct: 1971 AEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRI----LAM 2026
Query: 262 EEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKK--RKAQ 319
EE + + Q K K +K + KE + K + Q
Sbjct: 2027 EESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL-----IKKRESLSKEPAKLNKILKALQ 2081
Query: 320 EWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLI 379
+ E K+ Q EE +++ +KE R ++ + +E ++ EK++ + ++ ++L
Sbjct: 2082 KLTRDERKLTQ-EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLA 2140
Query: 380 SKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLL 439
K++ + + + +I+ K + +K ++ ++ + +E ++E+V+
Sbjct: 2141 RKQRKLANK---MRRMINKEEKMTEEESK------LARKHSEVILDDEEEGGIEEEEVIP 2191
Query: 440 WLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKME----EKNENLAKKRCSEE 495
+L ++ R KE ++ E S + + + EK E+L+ + E
Sbjct: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
Query: 496 LVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQI 555
++ER+ E + E + +G K+ +E K +KE+K E +K ++
Sbjct: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK------KEEVQEKEEV 2305
Query: 556 ILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL 614
+E E+ + EE + + D ++++ +EE+ + +L K+K + +++SL
Sbjct: 2306 F----EEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSL 2360
Score = 68.9 bits (167), Expect = 4e-11
Identities = 105/496 (21%), Positives = 225/496 (45%), Gaps = 48/496 (9%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVE-KKK 220
+VEEK Q E +K+++L + EK+ ++ + +KQ + +EK +++ V+ KK+
Sbjct: 1890 QVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949
Query: 221 LE---NIQKQEQDKMNDELYK--EEKI----WKEKFKQHEEYIRNLHLQMEE-ERTRFKD 270
L +I K+E+ +N E+ + EEK+ KE + E + +M + E+ F+
Sbjct: 1950 LRGELDIAKEEK-ALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFER 2008
Query: 271 QQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQ 330
+ E+ LL + A++ K + + + I + + +++ +K + +
Sbjct: 2009 KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK 2068
Query: 331 KEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILRE-D 389
+ + K L+ Q++ + +K +EE K + K+ + +ER I + K+ ++E D
Sbjct: 2069 EPAKLNKILKALQKLTRDERKLTQEEIKMTKM----KRALFVKERRLSIEQSKLDIKEWD 2124
Query: 390 ASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKE 449
S+ K+S L + + ++++ K E EES +
Sbjct: 2125 FSE--------KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTE-------EESKLAR 2169
Query: 450 NVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKK--RCSEELVKQERKYENTD 507
+ IL + + ++E + ++ K + AK+ + E+ Q + E+ +
Sbjct: 2170 K-HSEVILDDEEEGGIEE----EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEE 2224
Query: 508 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 567
+ +E S L K++ E + + ++EE+ + + E ++ + G E +V+
Sbjct: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG---EEKQVE 2281
Query: 568 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 627
EE+K K ++KK + EKEE+ E+ + +++T +S ++ E S + E
Sbjct: 2282 KEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEE-----EEESCSLEEE 2336
Query: 628 VILQEKEIYSKSKEIE 643
V +EKEI K K+ +
Sbjct: 2337 VD-REKEILKKEKQFK 2351
Score = 61.6 bits (148), Expect = 6e-09
Identities = 108/477 (22%), Positives = 210/477 (44%), Gaps = 62/477 (12%)
Query: 195 REEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDK--MNDELYKEEKIWKEKFKQHEE 252
REE+Q Q++ +++ +V KK + + E M E+ K+E+ K+ F++ +
Sbjct: 1345 REEEQAQKKARDM-LGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEE--KKTFQKSPK 1401
Query: 253 YIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIE 312
R +Q E + + K + KE+ + ++ V+ A + V Q+ ++ E+
Sbjct: 1402 QGRKA-VQKERKVGKIKREMTKEERDMSEE-----VEEMATLEEKVVKQEGKLVMIERTP 1455
Query: 313 SK---KRKAQEWKEKEAKIRQ-----KEEENRKRLEEEQRIKEERKKQKEEERKRREK-- 362
S K+ EWK+ + R+ KEE ++ L+EE+++ + +K EE +E
Sbjct: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Query: 363 -EYEEKKNI------VKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDI 415
++EE K + K + +Q +E++ L E+ S++ K+ + +++
Sbjct: 1516 LKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSRE----GEEKEQQVTEEQRHIQEE 1571
Query: 416 SNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKE----SIQVKLKESISS 471
K E + QE+ L EE +E +RQ +E VK+ +
Sbjct: 1572 HKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE--ERQLAQEERKLAQAYVKITQD-DR 1628
Query: 472 QTILADFKMEEKNENLAKK--RCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQE 529
+ A+ K +K E LA++ + S+E K +K + K E + + K+ L E
Sbjct: 1629 EMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAE 1688
Query: 530 LKSD-AQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEK 588
+K+ AQK E++ + N + +K QE+ E++ + E+ K+
Sbjct: 1689 VKNILAQKVEELPQREQNLDWQEKELA-----QELEELEWDMEELSWKE----------- 1732
Query: 589 EEIQEQNGLLYKDKDTLVISVK----QRSLSLTSENSKDVRENVILQEKEIYSKSKE 641
EE+ ++ G L ++K L + QR E E +++QEKE ++ KE
Sbjct: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKE 1789
Score = 57.4 bits (137), Expect = 1e-07
Identities = 81/398 (20%), Positives = 169/398 (42%), Gaps = 59/398 (14%)
Query: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEE 240
+E+ E K + R ++ F + + K K + KK E++ K E K+N L +
Sbjct: 2026 MEESEIAKGKLEFTRGQRIFVQGQRKL---AKASRKLIKKRESLSK-EPAKLNKILKALQ 2081
Query: 241 KIWKEKFKQHEE-----------YIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVK 289
K+ +++ K +E +++ L +E+ + K+ EK S L + +
Sbjct: 2082 KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLAR 2141
Query: 290 IQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEE- 348
Q K + ++ K ++ E+E+K+ +K E EEE I+EE
Sbjct: 2142 KQRK-------------LANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEE 2188
Query: 349 ------RKKQKEEERKRREKEYEEKKNIVKQ-EREQLISKEKIILREDASQQLIISSALK 401
R+ +K +E KR +K E+ + V + E E+ S+E L ++ +Q
Sbjct: 2189 VIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQ-------- 2240
Query: 402 KSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESI 461
E +S+++ + + +E +++E+V E +E ++Q +E
Sbjct: 2241 -----------ESLSSEEEEERE---EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE 2286
Query: 462 QVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNL 521
+ K K+ + + ++ E+ E + + +E L +E + E+ + E+
Sbjct: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKK 2346
Query: 522 KEQFPLQELKSDAQK-EEKIMKHVINENTGQKTQIILG 558
++QF LQE + + + E+++ + G+ I LG
Sbjct: 2347 EKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLG 2384
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/176 (26%), Positives = 90/176 (51%), Gaps = 21/176 (11%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDR------EEKQFQEEEEKRHCWMKQFK 215
E+E++ S E +E+++E E +E++ + + +R EEKQ ++EEE++ K+ K
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEK----KKKK 2291
Query: 216 VEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKE 275
EKKK E +K+E + +E+ EE+ ++ EE +EEE R K+ +KE
Sbjct: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEE----SCSLEEEVDREKEILKKE 2347
Query: 276 KNSLLKQQNNAAVKIQAKYKAFVAYQKYGP-------IIKEQIESKKRKAQEWKEK 324
K L++Q +++ + + + + +G ++K ++ A E KEK
Sbjct: 2348 KQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEK 2403
Score = 53.5 bits (127), Expect = 2e-06
Identities = 41/190 (21%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
+E + L++ EKQ + + EE++ +EE E+ +++ + E+K+ E ++++ +K +
Sbjct: 2228 EEMESLLDELEKQESLSSEEEEEREEEEEREEEE--VREEEEERKEEEEGEEKQVEKEEE 2285
Query: 235 ELYKEEKIWKEKFKQHEEYI--RNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQA 292
E K++K K++ Q +E + + EEE D++E+E++ L+++ + +I
Sbjct: 2286 EKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILK 2345
Query: 293 KYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQ 352
K K F +++ ++RK+ +E+ I + + R +K KK
Sbjct: 2346 KEKQF------------KLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKL 2393
Query: 353 KEEERKRREK 362
+ +EK
Sbjct: 2394 MSTALEMKEK 2403
Score = 31.2 bits (69), Expect = 9.1
Identities = 17/48 (35%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 1499 DKENLSSSEHTQFNSRSENKTSSWTPESKTSR-KSLLKSEKEKKISEE 1545
+KE + S E T+ S E + S + E + R K +LK EK+ K+ E+
Sbjct: 2308 EKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQ 2355
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 95.5 bits (236), Expect = 4e-19
Identities = 94/429 (21%), Positives = 212/429 (49%), Gaps = 82/429 (19%)
Query: 169 QSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE 228
+ + W+EK +E E+K ++ + R++EEK ++EE W K+ K+ ++ E + ++
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM---WEKEEKMRRQ--EEMMWEK 422
Query: 229 QDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQM-EEERTRFKDQQEKEKNSLLKQQNNAA 287
++KM + EE +W++ EE IR L +M E+E+ R ++++ +E+ + +Q+
Sbjct: 423 EEKMRRQ---EEMMWEK-----EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-- 472
Query: 288 VKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE---NRKRLEEEQR 344
+EQ R+ ++ +E+E KIR++EE+ +++ E+++
Sbjct: 473 --------------------QEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 345 IKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG 404
I+EE K+Q++EE R+E++ E++ I +Q+ + +EKI +E+
Sbjct: 513 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE--------------- 557
Query: 405 YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVK 464
K E+ +D+ +E ++QE+ +W EE K + I ++ +++
Sbjct: 558 ---KMWRQEEKMHDQ--------EEKIREQEE-KVWRQEE---KIREQEEKIREQEEKIR 602
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQ 524
+E ++ + + KM E+ E + ++ E++ +QE K + K ++ +++
Sbjct: 603 EQEEMTQE---QEEKMGEQEEKMCEQ--EEKMQEQEEKMRRQEEKIREQEKKIR---EQE 654
Query: 525 FPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQ 584
++E + Q++E+ M + Q+ ++ QE E +E+K+ + + + Q
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKM-----QEQEEKMRRQEEKMWEQEVRLRQQ 709
Query: 585 KVEKEEIQE 593
+ + +E QE
Sbjct: 710 EEKMQEHQE 718
Score = 93.2 bits (230), Expect = 2e-18
Identities = 63/247 (25%), Positives = 141/247 (57%), Gaps = 35/247 (14%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEE---EKRHCWMKQFKVEK 218
E EEK R+ E +++++ ++EK + +R +E+ +++EE E+ W ++ K+ +
Sbjct: 488 EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE 547
Query: 219 KKLENIQKQEQ------DKMNDELYK----EEKIWK--EKFKQHEEYIRNLHLQMEEERT 266
++ E I+KQE+ +KM+D+ K EEK+W+ EK ++ EE IR +EE+
Sbjct: 548 QE-EKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIRE-----QEEKI 601
Query: 267 RFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEA 326
R +++ +E+ + +Q + + K ++EQ E +R+ ++ +E+E
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEK-------------MQEQEEKMRRQEEKIREQEK 648
Query: 327 KIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIIL 386
KIR++EE+ R++ EE + +EE+ ++EE+ +E++ +E++ ++++ E++ +E +
Sbjct: 649 KIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 707
Query: 387 REDASQQ 393
+++ Q
Sbjct: 708 QQEEKMQ 714
Score = 92.0 bits (227), Expect = 4e-18
Identities = 105/511 (20%), Positives = 239/511 (46%), Gaps = 54/511 (10%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Q K+LE + + + D K E E+ Q K + +E + K E+D ++
Sbjct: 211 QHAVKQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTK-ERDALSL 268
Query: 235 ELYK----EEKIWKEKFKQHEEY-------------IRNLHLQMEEERTRFKDQQ-EKEK 276
ELY+ +E++ ++ K E+ ++ L ++E + QQ + E
Sbjct: 269 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 328
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK----EAKIRQKE 332
+ L K+ + + K+QA+ + + + +E++ ++ K QEW+EK E KIR++E
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 388
Query: 333 EENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKII--LREDA 390
E+ R++ EE+ R +EE +KEE+ +R+E+ EK+ ++++ E + KE+ I L E
Sbjct: 389 EKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 447
Query: 391 SQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVL------LW---- 440
+Q I +K K E + + + +E ++QE+ + +W
Sbjct: 448 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ--EEKIREQEEKIREQEEKMWRQEE 505
Query: 441 -LVEESNMKENVDRQ---TILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEEL 496
+ E+ ++E RQ + ++ +++ +E I Q K+ E+ E + K+ E++
Sbjct: 506 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ----KEKIHEQEEKIRKQ--EEKM 559
Query: 497 VKQERKYENTDNKTELGNSDL---KGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKT 553
+QE K + + K + + ++EQ + + +E++ M E G++
Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619
Query: 554 QIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRS 613
+ + +++ E + ++ K +Q+K + ++E+I+EQ ++ + ++ + ++
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM--WEQEEK 677
Query: 614 LSLTSENSKDVRENVILQEKEIYSKSKEIEE 644
+ E ++ E + QE++++ + + +
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 708
Score = 90.1 bits (222), Expect = 2e-17
Identities = 66/249 (26%), Positives = 143/249 (57%), Gaps = 20/249 (8%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK-- 219
E EEK R+ E EK++++ + E++ + ++ RE+++ ++EEEK K+ + E K
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 220 KLENIQKQEQDKMNDELYKEEKIWKEKFKQHE-EYIRNLHLQMEEE-----RTRFKDQQE 273
+ E +++++K+ ++ EEK+W+++ K HE E IR + E+E + ++Q+E
Sbjct: 481 RQEEKIREQEEKIREQ---EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 537
Query: 274 --KEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQK 331
++K + +Q+ + + ++ I+EQ E R+ ++ +E+E KIR++
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 332 EEENRKR----LEEEQRIKEERKKQKEEERKRREKEYE---EKKNIVKQEREQLISKEKI 384
EE+ R++ E+E+++ E+ +K E+E K +E+E + +++ I +QE++ +EKI
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Query: 385 ILREDASQQ 393
+E+ Q+
Sbjct: 658 REQEEMMQE 666
Score = 56.2 bits (134), Expect = 3e-07
Identities = 37/139 (26%), Positives = 82/139 (58%), Gaps = 12/139 (8%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
E EEK R+ E QE+++++ ++E++ + +E++ QE+EEK ++ + ++KK+
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCE-----QEEKMQEQEEKMRRQEEKIREQEKKI 650
Query: 222 ENIQKQ--EQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL 279
+++ EQ++M E +EEK+W+++ K E+ + +Q +EE+ R ++++ E+
Sbjct: 651 REQEEKIREQEEMMQE--QEEKMWEQEEKMCEQEEK---MQEQEEKMRRQEEKMWEQEVR 705
Query: 280 LKQQNNAAVKIQAKYKAFV 298
L+QQ + Q +A +
Sbjct: 706 LRQQEEKMQEHQEHLEAAI 724
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 91.7 bits (226), Expect = 6e-18
Identities = 58/241 (24%), Positives = 138/241 (57%), Gaps = 15/241 (6%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLEN 223
EEK R+ E +E++K++ +E++ + ++ REE++ QE+EE W ++ K+ +++
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM---WRQEEKIREQEEIW 478
Query: 224 IQKQEQDKMNDELYKEEKIWKEKFKQH--EEYIRNLHLQMEEERTRFKDQQEK------- 274
QK++ + +EEK+W+++ K H EE IR +M + + ++Q+EK
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK 538
Query: 275 --EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKE 332
E+ ++++Q + + K + ++ I+EQ E + + ++ +E+E KI ++E
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE 598
Query: 333 EENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQ 392
E+ R++ EE + +EE+ ++EE+ +E++ +E++ ++++ E++ +E + +++
Sbjct: 599 EKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 657
Query: 393 Q 393
Q
Sbjct: 658 Q 658
Score = 91.3 bits (225), Expect = 7e-18
Identities = 112/514 (21%), Positives = 239/514 (46%), Gaps = 48/514 (9%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Q K+LE + + + D K E E+ Q K + +E + K E+D ++
Sbjct: 150 QHAVKQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTK-ERDALSL 207
Query: 235 ELYK----EEKIWKEKFKQHEEY-------------IRNLHLQMEEERTRFKDQQ-EKEK 276
ELY+ +E++ ++ K E+ ++ L ++E + QQ + E
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK----EAKIRQKE 332
+ L K+ + + K+QA+ + + + +E++ ++ K QEW+EK E KIR++E
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 333 EENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKII--LREDA 390
E+ R++ EE+ R +EE +KEE+ +R+E+ EK+ +++ E + KE+ I L E
Sbjct: 328 EKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKM 386
Query: 391 SQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVL------LWLVEE 444
+Q I +K K E + + + +E ++QE+ + +W EE
Sbjct: 387 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ--EEKIREQEEKIREQEKKMWRQEE 444
Query: 445 S-NMKENVDRQTILKESIQV-KLKESISSQTILADFKMEEKNENLAKKRCSEELV-KQER 501
+ +E + + +E ++ + +E I Q + ++ +EK K R EE V +QE
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI--WRQKEKMHEQEKIRKQEEKVWRQEE 502
Query: 502 KYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQ 561
K D + ++ + K +E+ ++ + ++EEKI + E Q+ + +G +
Sbjct: 503 KMH--DQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE---QEEMMQEQEEKMGEQE 557
Query: 562 EISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENS 621
E + + ++ K +Q++ + +KE+I+EQ +++ ++ + +Q + E
Sbjct: 558 EKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKI---REQEEMMQEQEEK 614
Query: 622 KDVRENVILQEKEIYSKSKEIEENPKDNAWNSGI 655
+E + +++E + +E ++ W +
Sbjct: 615 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 648
Score = 90.9 bits (224), Expect = 1e-17
Identities = 125/613 (20%), Positives = 283/613 (46%), Gaps = 98/613 (15%)
Query: 8 LKAEIEAELDKLSISSLEKEDIE------SDAKSETQSDDSDT-----DSVELPESVLHC 56
L+ E+EA++ + I + +K +++ A + + + D DS + +
Sbjct: 121 LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQA 180
Query: 57 INIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSE 116
++ + + K + I + ++ D LS ++ T E +E + +L + L
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLE--------LYRNTITDEELKEKNAKLQEKLQL 232
Query: 117 IEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDAD-INFGYCEVEEKCR---QSFE 172
+E E +S+ + + L + + L +AD + V K + + E
Sbjct: 233 VESE---KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE 289
Query: 173 AWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKM 232
W ++ E+K + + ++ EEK QE+EEK ++ + +++K+ ++ +K
Sbjct: 290 LWNRLNQQQEEKMWRQEEKIQEWEEK-IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 233 NDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK--EKNSLLKQQNNAAVKI 290
+EE +W++ EE +R L M E+ + ++ +EK E+ + +Q+ K
Sbjct: 349 EKMRRQEEMMWEK-----EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE----KR 399
Query: 291 QAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENR----------KRLE 340
Q + K I+EQ + ++++A+ W+++E KIR++EE+ R +++
Sbjct: 400 QEEEK-----------IREQEKRQEQEAKMWRQEE-KIREQEEKIREQEKKMWRQEEKIH 447
Query: 341 EEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSAL 400
E+++I+EE K+Q++EE R+E++ E++ I +Q +E++ +EKI +E+
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ-KEKMHEQEKIRKQEE----------- 495
Query: 401 KKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKES 460
K E+ +D+ +E ++QE+ +W EE K + I ++
Sbjct: 496 -------KVWRQEEKMHDQ--------EEKIREQEE-KMWRQEE---KIREQEEKIREQE 536
Query: 461 IQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGN 520
+++ +E + + + EEK + K R EE ++ E++ + + K ++ + K
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR-EQEEKIREQKEKIREQEEK-I 594
Query: 521 LKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQ 580
+++ ++E + Q++E+ M + Q+ ++ QE E +E+K+ + +
Sbjct: 595 WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM-----QEQEEKMRRQEEKMWEQEVR 649
Query: 581 KKIQKVEKEEIQE 593
+ Q+ + +E QE
Sbjct: 650 LRQQEEKMQEHQE 662
Score = 86.3 bits (212), Expect = 2e-16
Identities = 77/352 (21%), Positives = 174/352 (49%), Gaps = 38/352 (10%)
Query: 162 EVEEKCRQSFE--------AWQEKQKELEDKEKQTLKAQRDR--EEKQFQEEEEKRHCWM 211
E EEK R+ E W++++K +E K ++ R EE +++EE+ R
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE 384
Query: 212 KQFKVEKKKLENIQKQEQDKMNDELYKEE---KIWK--EKFKQHEEYIRNLHLQMEEERT 266
K + EK + + ++QE++K+ ++ ++E K+W+ EK ++ EE IR +M +
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444
Query: 267 RFKDQQ---EKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKE 323
+ +Q+ E+EK ++ KI+ + + + +K + EQ + +K++ + W++
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK----MHEQEKIRKQEEKVWRQ 500
Query: 324 KEAKIRQKE---EENRKRLEEEQRIKEERKKQKEEERKRREKE--YEEKKNIVKQEREQL 378
+E Q+E E+ K +E++I+E+ +K +E+E K RE+E +E++ + ++ E++
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 379 ISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVL 438
+EK+ +E+ ++ +K + + + + + + ++ K E
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 439 LWLVEESNMKENVDRQTILKESI---QVKLKESISSQTILADFKMEEKNENL 487
+E M+E ++ +E + +V+L++ + KM+E E+L
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ--------EEKMQEHQEHL 664
Score = 56.6 bits (135), Expect = 2e-07
Identities = 40/140 (28%), Positives = 84/140 (60%), Gaps = 8/140 (5%)
Query: 162 EVEEKCRQSFEAWQEKQKEL-EDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKK 220
E EEK R+ E QE+++++ E +EK + + R+E++ +E+EEK ++ + +++K
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 221 L-ENIQK-QEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNS 278
+ E +K +EQ++M E +EEK+W+++ K E+ + +Q +EE+ R ++++ E+
Sbjct: 594 IWEQEEKIREQEEMMQE--QEEKMWEQEEKMCEQEEK---MQEQEEKMRRQEEKMWEQEV 648
Query: 279 LLKQQNNAAVKIQAKYKAFV 298
L+QQ + Q +A +
Sbjct: 649 RLRQQEEKMQEHQEHLEAAI 668
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 89.7 bits (221), Expect = 2e-17
Identities = 106/468 (22%), Positives = 208/468 (44%), Gaps = 52/468 (11%)
Query: 175 QEKQKELEDKEKQTLKAQRDR------EEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE 228
++K+KE E++EK + + EEK + +EE +K ++ + E Q++E
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE--EPKQEEE 243
Query: 229 QDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK---EKNSLLKQQNN 285
+++ +DE+ EK+ +E ++ E L EER R K +Q+K ++ + ++ +
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEA---EERERIKAEQDKKIADERARIEAEEK 300
Query: 286 AAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRI 345
AA + + + +A + + E ++ K +E + E + R KEEE R EE QRI
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA-EERQRI 359
Query: 346 KEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGY 405
KEE K+ EE R+R E EEK + +Q+R + + ++K ++E + + ++
Sbjct: 360 KEEEKRAAEE-RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV 418
Query: 406 NNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ-VK 464
N K + + + K +E K V+ K D+ T KE I+ K
Sbjct: 419 NEKKAQEDKLQT---AVLKKQGEEKGTK--------VQAKREKLQEDKPTFKKEEIKDEK 467
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENT----------DNKTELGN 514
+K+ + + F +K K + E + + + ENT D K G
Sbjct: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 527
Query: 515 SDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKI 574
++ K L+ + + + EE E QK Q +E+ + K E +K+
Sbjct: 528 PQVEAG-KRLEELRRRRGETESEE-------FEKLKQKQQEAALELEELKK-KREERRKV 578
Query: 575 IKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSK 622
+++ +Q++ Q+ +++E+ ++K L +++R + K
Sbjct: 579 LEEEEQRRKQEEADRKLREE-----EEKRRLKEEIERRRAEAAEKRQK 621
Score = 81.3 bits (199), Expect = 8e-15
Identities = 127/585 (21%), Positives = 268/585 (45%), Gaps = 89/585 (15%)
Query: 13 EAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKA-VEELI 71
E E + S +K D +++ + + + + E P+ +I +N+ + VEE
Sbjct: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG----SIGENQVEVMVEEKT 216
Query: 72 LQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCAT 131
+ E+T ++S G +S+ E E+ S++ I ++E+E+ R++ + A
Sbjct: 217 TESQEETVVMSLKNGQISSEEPKQEE----EREQGSDE-ISHHEKMEEEDKERAEAERAR 271
Query: 132 PDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKA 191
+ E D+ + + A I E EEK A + +++E E++E+ +
Sbjct: 272 LE-AEERERIKAEQDKKIADERARI-----EAEEKAA----AQERERREAEERERMREEE 321
Query: 192 QRDREEKQFQEEEEKRHCWMKQ-FKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQH 250
+R EE+Q +EEEKR +Q K E+K+ +E+ ++ +E E++ +E+ +
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKR----AAEERQRIKEE---EKRAAEERQRAR 374
Query: 251 EEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQ 310
E EEE+ + +E+++N L+++ +A + + K G ++++
Sbjct: 375 AE---------EEEKAKV---EEQKRNKQLEEKKHAMQETKIK----------GEKVEQK 412
Query: 311 IESK---KRKAQEWKEKEAKIRQKEEE-------NRKRLEEE------QRIKEERKKQKE 354
IE K ++KAQE K + A ++++ EE R++L+E+ + IK+E+ K+ +
Sbjct: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 472
Query: 355 EERKRREKEYEEKKNI--VKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLS- 411
E ++ + + KK VK + + ++ + S+ +S K +
Sbjct: 473 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 532
Query: 412 ---LEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKES 468
LE++ +G+ ++ +KQ++ L L E +E +R+ +L+E Q + +E
Sbjct: 533 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEE 590
Query: 469 ISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQ 528
AD K+ E+ E K+R EE+ + R+ E + + ++ L + K+ F
Sbjct: 591 -------ADRKLREEEE---KRRLKEEI--ERRRAEAAEKRQKMPEDGLSDD-KKPFKCF 637
Query: 529 ELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEI-SEVKTNEEQ 572
K + K E+ +N++ + + + H I S++ + EQ
Sbjct: 638 TPKGSSLKIEE-RAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 681
Score = 71.2 bits (173), Expect = 8e-12
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 77/528 (14%)
Query: 164 EEKCRQSFEAWQEKQKELEDK------EKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVE 217
EE+ ++ + E+QKE + + + Q D E + E+EEK +++++E
Sbjct: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
Query: 218 KKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRN-------LHLQMEEERTRFKD 270
+ + Q+ D + E K+E KEK ++ EE + + + +EE+ T ++
Sbjct: 164 ETETVTKSYQKNDWRDAEENKKED--KEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQE 221
Query: 271 Q------------QEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKR-K 317
+ E+ K ++Q + + K + + + + E ++R K
Sbjct: 222 ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK 281
Query: 318 AQEWK---EKEAKIRQKE-----EENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKN 369
A++ K ++ A+I +E E R+ EE +R++EE K+ EE ++ +E EEK+
Sbjct: 282 AEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE---EEKRA 338
Query: 370 IVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDE 429
+ER+++ +EK A ++ I K++ + E+ K + ++
Sbjct: 339 A--EERQRIKEEEK----RAAEERQRIKEEEKRAAEERQRARAEEEEKAK------VEEQ 386
Query: 430 NSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAK 489
KQ + ++E+ +K Q I + + K + QT + + EEK +
Sbjct: 387 KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQA 446
Query: 490 KRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENT 549
KR E+L QE K T K E+ + +K K++ P +E+KS +++ + +
Sbjct: 447 KR--EKL--QEDK--PTFKKEEIKDEKIK---KDKEPKEEVKSFMDRKKGFTE--VKSQN 495
Query: 550 GQKTQIILGHNQEI-------SEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDK 602
G+ L H + + V T E + + K+++++ + + ++ K K
Sbjct: 496 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 555
Query: 603 DTLVISVKQRSLSLTSENSKDVRE--NVILQEKEIYSKSKEIEENPKD 648
KQ+ +L E K RE +L+E+E K +E + ++
Sbjct: 556 Q------KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 597
Score = 66.2 bits (160), Expect = 3e-10
Identities = 91/495 (18%), Positives = 207/495 (41%), Gaps = 65/495 (13%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDE 235
E+++EL ++++ ++ + +R Q +++E+ ++ + +++L QKQE++ +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLR--QKQEEESLGQV 62
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQME--------EERTRFKDQQEKEKNSLLKQQNNAA 287
+ E + E + Q+E E R +++++K L++Q
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 288 VKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK----EAKIRQKEEENRKRLEEEQ 343
I + + + + + K+ K++ +E+ E + K + + E+
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
Query: 344 RIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIIL----------------- 386
KE+++K++EEE K + E + V E + S+E+ ++
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 387 -REDASQQLIISSAL-----KKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLW 440
RE S ++ + +++ L E+ K + K + DE ++ + +
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE---- 298
Query: 441 LVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEE---LV 497
E++ +E R+ +E ++ + K + + + K EEK ++R EE
Sbjct: 299 --EKAAAQERERREAEERERMREEEKRAAEERQRI---KEEEKRAAEERQRIKEEEKRAA 353
Query: 498 KQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINEN--TGQKTQI 555
++ ++ + + + + +E+ ++E K + Q EEK KH + E G+K +
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEK--KHAMQETKIKGEKVE- 410
Query: 556 ILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEE----IQEQNGLLYKDKDTL-VISVK 610
Q+I E K E+K +D Q + K + EE +Q + L +DK T +K
Sbjct: 411 -----QKI-EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK 464
Query: 611 QRSLSLTSENSKDVR 625
+ E ++V+
Sbjct: 465 DEKIKKDKEPKEEVK 479
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 89.0 bits (219), Expect = 4e-17
Identities = 63/251 (25%), Positives = 139/251 (55%), Gaps = 25/251 (9%)
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQ----------RDREEKQFQEEEEKRHCWMKQ 213
EEK ++ E QE+++++ ++E++ + + R +EE +++EE+ R K
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 214 FKVEKKKLENIQKQEQDKMNDELYKEE---KIWK--EKFKQHEEYIRNLHLQMEEERTRF 268
+ EK + + ++QE++K+ ++ ++E K+W+ EK ++ EE IR M+E+ +
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKM 413
Query: 269 KDQQEK--EKNSLLKQQNNAAVKIQAKYK-AFVAYQKYGPIIKEQIESKKRKAQEWKEKE 325
+Q+EK E+ +++Q + + K + ++ I+EQ E + + ++ E+E
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Query: 326 AKIRQKE----EENRKRLEEEQRIKEERKKQKEEERKRREKE---YEEKKNIVKQEREQL 378
K+ ++E E+ K +E++I+E+ KK +E+E K RE+E E+++ + +QE +
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 379 ISKEKIILRED 389
+EK+ +E+
Sbjct: 534 EQEEKMQEQEE 544
Score = 84.3 bits (207), Expect = 9e-16
Identities = 58/241 (24%), Positives = 131/241 (54%), Gaps = 37/241 (15%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
E EEK R+ E + +++ + +KE++ R +EE +++EE+ R K + EK +
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEK----MRRQEEMMWEKEEKIRELEEKMHEQEKIRE 361
Query: 222 ENIQKQEQDKMNDELYKEE---KIWK--EKFKQHEEYIRNLHLQMEEERTRFKDQQEK-- 274
+ ++QE++K+ ++ ++E K+W+ EK ++ EE IR M+E+ + +Q+EK
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKE-- 332
E+ +++Q ++ Q E + + ++ +E+E KIR++E
Sbjct: 422 EQEEEMQEQEEK--------------------MRRQEEKIREQEKKIREQEEKIREQEEM 461
Query: 333 --EENRKRLEEEQRIKEERKKQKEEERK--RREKEYEEKKNIVKQEREQLISKEKIILRE 388
E+ K E+E ++ E+ K +E+E K R+E++ E++ ++++ E++ +E+++ +
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 521
Query: 389 D 389
+
Sbjct: 522 E 522
Score = 82.4 bits (202), Expect = 3e-15
Identities = 94/433 (21%), Positives = 212/433 (48%), Gaps = 68/433 (15%)
Query: 8 LKAEIEAELDKLSISSLEKEDIE------SDAKSETQSDDSDT-----DSVELPESVLHC 56
L+ E+EA++ + I + +K +++ A + + + D DS + +
Sbjct: 109 LRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQA 168
Query: 57 INIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSE 116
++ + + K + I + ++ D LS ++ T E +E + +L + L
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLE--------LYRNTITDEELKEKNAKLQEKLQL 220
Query: 117 IEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFG----------YCEVEEK 166
+E E +S+ + + L + + L +AD + G +VEE
Sbjct: 221 VESE---KSEIQLNVKELKRKLERAKLLLPQQQLQAEAD-HLGKELQSVSAKLQAQVEEN 276
Query: 167 -------CRQSFEAWQEKQK--ELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVE 217
+Q + W++++K E E+K ++ + R++EEK ++EE W K+ K+
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM---WEKEEKMR 333
Query: 218 KKKLENIQKQEQDK-MNDELYKEEKIWKEKFK-QHEEYIRNLHLQMEEE------RTRFK 269
+++ +K+E+ + + ++++++EKI +++ K Q EE IR + E+E + +
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 393
Query: 270 DQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327
+Q+EK E+ ++++Q + + K + ++EQ E +R+ ++ +E+E K
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEK------MWEQEEEMQEQEEKMRRQEEKIREQEKK 447
Query: 328 IRQKEEENRKR----LEEEQRIKEERKKQKEEERKRREKEYE---EKKNIVKQEREQLIS 380
IR++EE+ R++ E+E+++ E+ K E+E K +E+E + +++ I +QE++
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 381 KEKIILREDASQQ 393
+EKI +E+ Q+
Sbjct: 508 EEKIREQEEMMQE 520
Score = 81.6 bits (200), Expect = 6e-15
Identities = 98/490 (20%), Positives = 226/490 (46%), Gaps = 86/490 (17%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Q K+LE + + + D K E E+ Q K + +E + K E+D ++
Sbjct: 138 QHAVKQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTK-ERDALSL 195
Query: 235 ELYK----EEKIWKEKFKQHEEY-------------IRNLHLQMEEERTRFKDQQ-EKEK 276
ELY+ +E++ ++ K E+ ++ L ++E + QQ + E
Sbjct: 196 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 255
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENR 336
+ L K+ + + K+QA+ + + + ++Q E R+ ++ +E+E KI+++EE+ R
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLN---QQQEEKMWRQEEKIQEREEKIQEQEEKIR 312
Query: 337 KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLII 396
++ EE+ R +EE +KEE+ +R+E+ EK+ +++ E++ +EKI +E+ Q+
Sbjct: 313 EQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--- 368
Query: 397 SSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEES--NMKENVDRQ 454
+ + ++ +++++ +W EE +E + Q
Sbjct: 369 --------------------------EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 402
Query: 455 TILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGN 514
+ + + K+ E + KM E+ E + ++ E++ +QE K + K
Sbjct: 403 EEMMQEQEEKMGEQ--------EEKMWEQEEEMQEQ--EEKMRRQEEKIREQEKKIR--- 449
Query: 515 SDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKI 574
+++ ++E + Q++E+ M + Q+ ++ QE E +E+KI
Sbjct: 450 -------EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM-----QEQEEKMRRQEEKI 497
Query: 575 IKDNQQKKIQKVEKEEIQEQNGLLYKDKDTL---VISVKQRSLSLTSENSKDVRENVILQ 631
Q+KKI++ ++E+I+EQ ++ + ++ + + ++ + + K R+ ++
Sbjct: 498 --REQEKKIRE-QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Query: 632 EKEIYSKSKE 641
E+E+ + +E
Sbjct: 555 EQEVRLRQQE 564
Score = 59.3 bits (142), Expect = 3e-08
Identities = 43/191 (22%), Positives = 103/191 (53%), Gaps = 36/191 (18%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQ--FQEEEEKRHCWMKQFKVEKK 219
E EEK R+ E QE+++++ ++E++ + + + +E++ + +EEK K+ + +++
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 220 KL---ENIQKQEQDKMNDELYK-----------EEKIWK--EKFKQHEEYIRNLHLQMEE 263
K+ E + +++++KM ++ K EEK+ + EK ++ E+ IR +E
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE-----QE 508
Query: 264 ERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKE 323
E+ R +++ +E+ + +Q + + K ++EQ E +R+ ++ +E
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEK-------------MQEQEEKMRRQEEKMRE 555
Query: 324 KEAKIRQKEEE 334
+E ++RQ+EE+
Sbjct: 556 QEVRLRQQEEK 566
Score = 57.0 bits (136), Expect = 2e-07
Identities = 73/449 (16%), Positives = 195/449 (43%), Gaps = 30/449 (6%)
Query: 217 EKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEK 276
+KKK+ N E E++ ++ QH+E +R L+ + + R Q+ E
Sbjct: 74 KKKKINNGTNPETTTSGGCHSPEDE--QKASHQHQEALRR-ELEAQVQTIRILTCQKTEL 130
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENR 336
L +A +++ + + ++ ++E K+K + ++ + R
Sbjct: 131 QMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKER 190
Query: 337 KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLII 396
L E R +EE K + + +EK +V+ E+ ++ K + R+ +L++
Sbjct: 191 DALSLELY----RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 246
Query: 397 SSALKKSGYNNKHLSLEDISND-KGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQT 455
++ ++ L+ +S + + +N + +Q++ +W EE ++E ++
Sbjct: 247 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK-IQEREEKIQ 305
Query: 456 ILKESIQVKLKESISSQTILAD------------FKMEEKNENLAKKRCSEELVKQERKY 503
+E I+ + ++ + ++ + ++ EEK L +K +E ++++ +
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 365
Query: 504 ENTDNKTELGNSDLKGNLK---EQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHN 560
+ K + K ++ ++E + +++E++M+ E G++ + +
Sbjct: 366 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ-EEKMGEQEEKMWEQE 424
Query: 561 QEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTL-----VISVKQRSLS 615
+E+ E + ++ K +Q+K + ++E+I+EQ ++ + ++ + + ++ +
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 616 LTSENSKDVRENVILQEKEIYSKSKEIEE 644
E + E + QEK+I + ++I E
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Score = 42.4 bits (98), Expect = 0.004
Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 24/114 (21%)
Query: 161 CEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKK 220
CE E K ++ E + +++++ ++EK+ R++EEK ++EE + K ++ E+K
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKI----REQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 221 LENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
E +EK ++ EE +R +M E+ R + Q+EK
Sbjct: 533 CEQ--------------------EEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 36.6 bits (83), Expect = 0.22
Identities = 23/92 (25%), Positives = 56/92 (60%), Gaps = 9/92 (9%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQ---RDREEKQFQEEEEKRHCWMKQFKVEK 218
E EEK R+ E +E++K++ ++E++ + + +++EEK +++EE+ C ++ E+
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM--CEQEEKMQEQ 542
Query: 219 KKLENIQKQEQDKMNDELYKEEKIWKEKFKQH 250
+ E +++QE+ E+ ++ +EK ++H
Sbjct: 543 E--EKMRRQEEKMREQEVRLRQQ--EEKMQEH 570
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 88.6 bits (218), Expect = 5e-17
Identities = 102/456 (22%), Positives = 214/456 (46%), Gaps = 77/456 (16%)
Query: 153 DADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMK 212
D ++ E++EK R E Q ++D +++ +AQ ++Q Q E ++ ++
Sbjct: 213 DEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQ 272
Query: 213 ------QFKVEKKKLENIQKQEQDKMNDELYKEEKIWK--EKFKQHEEYIRNLHLQMEEE 264
Q +VE+ +L N+ Q+Q EEK+W+ EK ++ EE + L++ E+
Sbjct: 273 SVSAKLQAQVEENELWNLLNQQQ---------EEKMWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 265 RTRFKDQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWK 322
+ Q+EK E+ +++Q + + + K + + I+EQ E R+ ++ +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR------EQEEKIREQEEKMWRQEEKIR 377
Query: 323 EKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKE 382
E++ KI+++EEE +E++I+E+ +K++E+ ++ +K E+ + I +QE E +E
Sbjct: 378 EQDEKIQEQEEE---MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE 434
Query: 383 KIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLV 442
KI RE LE++ D+ + L + K QE
Sbjct: 435 KI--RE-----------------------LEEMMQDQ---EEKLREVEEKMQE------- 459
Query: 443 EESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKK--RCSEELVKQE 500
EE M+E ++ +E IQ + +++ + +L K EEK +K R E++ +QE
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL---KQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 501 RKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINE--NTGQKTQIILG 558
K + + K + ++ +++ L + + Q++E ++ + GQK +++ G
Sbjct: 517 EKMQEQEEKMQRQEEKMR---EQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573
Query: 559 HNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQ 594
+E + I+ Q +++ E + +Q+Q
Sbjct: 574 AGRESGSQRLPTLTPIL----QVELKSQEAQSLQQQ 605
Score = 56.6 bits (135), Expect = 2e-07
Identities = 102/554 (18%), Positives = 226/554 (40%), Gaps = 76/554 (13%)
Query: 227 QEQDKMNDELY---KEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQ 283
++Q K+ ++ + +E+ I EKF Q E L + R+ + + E++ KQ
Sbjct: 40 EQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQC 99
Query: 284 NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQ 343
+ ++ A + G + K+ + E K K ++K E +
Sbjct: 100 KESLKRVTFTLPDDEAIEDAG------VSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRV 153
Query: 344 RIKEERKKQKE-EERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKK 402
IK+ + E +KR E E+ EK+ DA + + +
Sbjct: 154 VIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITD 213
Query: 403 SGYNNKHLSLED----ISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILK 458
K+ L++ + ++K +I N+ D K + LL + + ++ DR
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLL--LPQQQLQVEADRLGKEL 271
Query: 459 ESIQVKLKESISSQTILADFKMEEKNE--NLAKKRCSEELVKQERKYENTDNKTELGNSD 516
+S+ KL+ + E+NE NL ++ E++ +QE K + + K + +
Sbjct: 272 QSVSAKLQAQV------------EENELWNLLNQQQEEKMWRQEEKIQEQEEK--MCEQE 317
Query: 517 LKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIK 576
LK +E+ ++ + ++EEKI + + ++ + I ++I E +E+K+ +
Sbjct: 318 LKIREQEEKMWRQEEKMHEQEEKIREQ--EDKMWRQEEKIREQEEKIRE----QEEKMWR 371
Query: 577 DNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSK--DVRENVILQEKE 634
Q++KI++ + E+IQEQ +++ ++ + ++R + + K + E + QE+E
Sbjct: 372 --QEEKIRE-QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEE 428
Query: 635 IYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAES 694
++ + ++I E +E DQ+ E L +
Sbjct: 429 MWRQEEKIRE----------------------LEEMMQDQE---------EKLREVEEKM 457
Query: 695 SMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLE 754
+++ + +I+ EK E + + + ++ EE+ W + K W +
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK--MWRQEEKMWEQ 515
Query: 755 IFKQNQQKKIVRRK 768
K +Q++ ++R+
Sbjct: 516 EEKMQEQEEKMQRQ 529
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 88.6 bits (218), Expect = 5e-17
Identities = 102/456 (22%), Positives = 214/456 (46%), Gaps = 77/456 (16%)
Query: 153 DADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMK 212
D ++ E++EK R E Q ++D +++ +AQ ++Q Q E ++ ++
Sbjct: 213 DEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQ 272
Query: 213 ------QFKVEKKKLENIQKQEQDKMNDELYKEEKIWK--EKFKQHEEYIRNLHLQMEEE 264
Q +VE+ +L N+ Q+Q EEK+W+ EK ++ EE + L++ E+
Sbjct: 273 SVSAKLQAQVEENELWNLLNQQQ---------EEKMWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 265 RTRFKDQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWK 322
+ Q+EK E+ +++Q + + + K + + I+EQ E R+ ++ +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR------EQEEKIREQEEKMWRQEEKIR 377
Query: 323 EKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKE 382
E++ KI+++EEE +E++I+E+ +K++E+ ++ +K E+ + I +QE E +E
Sbjct: 378 EQDEKIQEQEEE---MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE 434
Query: 383 KIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLV 442
KI RE LE++ D+ + L + K QE
Sbjct: 435 KI--RE-----------------------LEEMMQDQ---EEKLREVEEKMQE------- 459
Query: 443 EESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKK--RCSEELVKQE 500
EE M+E ++ +E IQ + +++ + +L K EEK +K R E++ +QE
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL---KQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 501 RKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINE--NTGQKTQIILG 558
K + + K + ++ +++ L + + Q++E ++ + GQK +++ G
Sbjct: 517 EKMQEQEEKMQRQEEKMR---EQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573
Query: 559 HNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQ 594
+E + I+ Q +++ E + +Q+Q
Sbjct: 574 AGRESGSQRLPTLTPIL----QVELKSQEAQSLQQQ 605
Score = 57.8 bits (138), Expect = 9e-08
Identities = 101/551 (18%), Positives = 230/551 (41%), Gaps = 70/551 (12%)
Query: 227 QEQDKMNDELY---KEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQ 283
++Q K+ ++ + +E+ I EKF Q E L + R+ + + E++ KQ
Sbjct: 40 EQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQC 99
Query: 284 NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKR--LEE 341
+ ++ A + G + ++ +K+++ K+ +K RKR +++
Sbjct: 100 KESLKRVTFTLPDDEAIEDAG--VSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKK 157
Query: 342 EQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALK 401
E QK E E+ + + ++KE+ L + + I LK
Sbjct: 158 PWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELK 217
Query: 402 KSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESI 461
+ + L + ++K +I N+ D K + LL + + ++ DR +S+
Sbjct: 218 EKNAELQE-KLRLVESEKSEIQLNVKDLKRKLERAQLL--LPQQQLQVEADRLGKELQSV 274
Query: 462 QVKLKESISSQTILADFKMEEKNE--NLAKKRCSEELVKQERKYENTDNKTELGNSDLKG 519
KL+ + E+NE NL ++ E++ +QE K + + K + +LK
Sbjct: 275 SAKLQAQV------------EENELWNLLNQQQEEKMWRQEEKIQEQEEK--MCEQELKI 320
Query: 520 NLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQ 579
+E+ ++ + ++EEKI + + ++ + I ++I E +E+K+ + Q
Sbjct: 321 REQEEKMWRQEEKMHEQEEKIREQ--EDKMWRQEEKIREQEEKIRE----QEEKMWR--Q 372
Query: 580 QKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSK--DVRENVILQEKEIYS 637
++KI++ + E+IQEQ +++ ++ + ++R + + K + E + QE+E++
Sbjct: 373 EEKIRE-QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431
Query: 638 KSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMV 697
+ ++I E +E DQ+ E L +
Sbjct: 432 QEEKIRE----------------------LEEMMQDQE---------EKLREVEEKMQEE 460
Query: 698 SKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFK 757
+++ + +I+ EK E + + + ++ EE+ W + K W + K
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK--MWRQEEKMWEQEEK 518
Query: 758 QNQQKKIVRRK 768
+Q++ ++R+
Sbjct: 519 MQEQEEKMQRQ 529
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 88.6 bits (218), Expect = 5e-17
Identities = 146/705 (20%), Positives = 312/705 (44%), Gaps = 92/705 (13%)
Query: 3 DDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKN 62
+++ K + E +AEL+K I ++E S+ K+ T S + ++ +++ K+
Sbjct: 855 ENELKNEKEEKAELNK-QIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAE-LHVQKS 912
Query: 63 RSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEF 122
+++ EE I++ + + + S ++NN ++ + T+ +E + + +S+I +
Sbjct: 913 KNQEQEEKIMKLSNEIETATRS---ITNNVSQIKL-MHTKIDEL--RTLDSVSQISNIDL 966
Query: 123 M--RSKTDCATPDFVPEPSPHDLPMD--------EHVLPDDADINFGYCEVE---EKCRQ 169
+ R ++ + D +P L D E+ + + N + +E E+C++
Sbjct: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKE 1026
Query: 170 SFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEE----EEKRHCWMKQFKVEKKKLENIQ 225
+A +K ++E+ E+Q K Q E K +++E +EK H EK+ L
Sbjct: 1027 IVKASSKKSHQIEELEQQIEKLQ--AEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQL 1084
Query: 226 KQEQDKMN-----------------DELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRF 268
K+E + N EL + +K K K+ E + ++
Sbjct: 1085 KEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLE 1144
Query: 269 KDQQEKEKNSLLKQQNNAAVK--IQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEA 326
+D EKE L ++N + +Q K +KE+I Q+ K
Sbjct: 1145 QDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKH--- 1201
Query: 327 KIRQKEEENRKRLEEEQRIKEE------RKKQKEEERKRREKEYEEKKNIVKQEREQL-- 378
++ KEEE +E +++KEE R + + + +R+E++Y + K + ++Q+
Sbjct: 1202 LLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQ 1261
Query: 379 ISKEKIILR-EDASQQLIISSALKKSGYNNKHLSLED--ISNDKGDIAKNLVDENSKKQE 435
+ KE ++R ED ++ I+ KK ++ L ++ I K + V+E ++ E
Sbjct: 1262 VQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYE 1321
Query: 436 DVLLWLVEESNMKENV--DRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCS 493
++ N+KE + D + L+E Q ++++ + L + + K++C+
Sbjct: 1322 RA----CKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCN 1377
Query: 494 EELVKQERKYENTDNKTELGNSDLKG---NLKEQFPLQELKSDAQKEEKIMKHVINENTG 550
+ E K NK N+D+ G NL+++ E K +A +++ +
Sbjct: 1378 D----LETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWL---------- 1423
Query: 551 QKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKE----EIQEQNGLLYK---DKD 603
++ +++ +E ++ E +K +D ++ Q+ E E ++ E++ L K ++D
Sbjct: 1424 EEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERD 1483
Query: 604 TLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKD 648
LV +++ + +L S N + ++N I Q K I S++ +IE D
Sbjct: 1484 QLVAALEIQLKALISSNVQ--KDNEIEQLKRIISETSKIETQIMD 1526
Score = 74.7 bits (182), Expect = 7e-13
Identities = 158/832 (18%), Positives = 332/832 (39%), Gaps = 130/832 (15%)
Query: 7 KLKAEI---EAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNR 63
++KAE+ + EL K L+K + ESD+ + + + S+ + + + INII +
Sbjct: 679 QIKAELAKTKGELIKTK-EELKKRENESDSLIQ-ELETSNKKIITQNQRIKELINIIDQK 736
Query: 64 SKAVEELI-----------LQDLEDTDILSCSYGAVSNNHMHL----RTGLSTEYEESSE 108
+ E D DT L + + N + + ++ + +E + +E
Sbjct: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
Query: 109 QLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADI-NFGYCEVEEKC 167
+E++++E K + E D E V P+ A+I + + +
Sbjct: 797 ------NELQQDEPPAKKGSIHVSSAITE----DQKKSEEVRPNIAEIEDIRVLQENNEG 846
Query: 168 RQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFK---------VEK 218
++F E + + E +EK L Q +++ E+K K+ + + +
Sbjct: 847 LRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAE 906
Query: 219 KKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQ------ 272
++ + QEQ++ +L E + + I+ +H +++E RT Q
Sbjct: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
Query: 273 --------EKEKNSLLKQQ-----NNAAVKIQAKYKAFVAYQK---YGPIIKEQIESKKR 316
E+++L Q N+ V Q K + + I+ E K
Sbjct: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKE 1026
Query: 317 KAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQERE 376
+ +K +I + E++ K E + K+E + KE+E K ++ +EK+ +++Q +E
Sbjct: 1027 IVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKE 1086
Query: 377 QLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQED 436
+L K + D Q ++ S + ++ K I K+ E
Sbjct: 1087 ELQEKNVTL---DVQIQHVVEGKRALSELT------QGVTCYKAKI---------KELET 1128
Query: 437 VLLWLVEESNMKENVDRQTILKESIQVKLKESISS-QTILADFKMEEKNENLAKKRCSEE 495
+L E + +++ + KESI +KL+ ++ Q L D K+ N+ + + EE
Sbjct: 1129 ILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEE 1188
Query: 496 LVKQERKYENTDNKTELGNSDLKGNLKEQFPLQE-----------LKSDAQKEEKIMKHV 544
+ + ++ + +L + + N +E L+E LK+D Q++E+ +
Sbjct: 1189 ITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADL 1248
Query: 545 INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDT 604
+ T K QI + +E +++D + K+ +++ E++++ K++ +
Sbjct: 1249 KEKLTDAKKQI----------KQVQKEVSVMRD--EDKLLRIKINELEKK-----KNQCS 1291
Query: 605 LVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTM 664
+ +KQR++ E + + +Q+ E K ++E +I + T+
Sbjct: 1292 QELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEK----------IIEDMRMTL 1341
Query: 665 INIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDS 724
E + +QD VL A E + E ++ N L+++ S K HEN +
Sbjct: 1342 EEQEQTQVEQDQVL--EAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHEN-----N 1394
Query: 725 MTCCVSESTLLYSIEERRLAWIKSFKPWLE----IFKQNQQKKIVRRKRPVK 772
+ L ++E + K WLE + Q ++ + +R K K
Sbjct: 1395 TDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKK 1446
Score = 68.2 bits (165), Expect = 7e-11
Identities = 126/583 (21%), Positives = 241/583 (41%), Gaps = 93/583 (15%)
Query: 176 EKQKELEDKEKQTLKAQRDR---EEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQE---Q 229
E +E ++ E + L D+ E K F EEKR + + KKKL N +K++ +
Sbjct: 540 ENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKL-LDLIEDLKKKLINEKKEKLTLE 598
Query: 230 DKMNDELYKE-EKIWKEKFKQHEEYIRNLHLQMEEERTR----FKD---------QQEKE 275
K+ +E+ +E + W ++ +E + +EE R FKD + K+
Sbjct: 599 FKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKD 658
Query: 276 KNSLLKQQNNAAVKIQAKY---KAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKE 332
+ + A ++ K+ KA +A K G +IK + E KKR+ E ++ I++ E
Sbjct: 659 ICATKVETEEATACLELKFNQIKAELAKTK-GELIKTKEELKKRE----NESDSLIQELE 713
Query: 333 EENRKRLEEEQRIKE-----ERKKQKEEERKRREKEYEEK-KNIVKQEREQLISKEKIIL 386
N+K + + QRIKE ++K+ E + + E K K + LI K+I
Sbjct: 714 TSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLIC 773
Query: 387 REDASQQLIISSAL--KKSGYNNKHLSLEDISNDKGDI-AKNLVDENSKKQEDVLLWLVE 443
E S + ++ N L ++ KG I + + E+ KK E+V
Sbjct: 774 NETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEV------ 827
Query: 444 ESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKY 503
N+ E E I+V + + + L + E KNE K ++++V +++
Sbjct: 828 RPNIAE--------IEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQEL 879
Query: 504 ENTDNKTELGNSDLKGNLKEQFPLQELKSDAQK------EEKIMKHVINENTGQKTQIIL 557
++ K + +++ ++ + + + QK EEKIMK ++ T+ I
Sbjct: 880 SLSEKKNLTLSKEVQ-QIQSNYDIAIAELHVQKSKNQEQEEKIMK--LSNEIETATRSIT 936
Query: 558 GHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQE-QNGLLYKDKDTLVISVKQRSLSL 616
+ +I + T ++ D+ +I ++ +++ NG ++D L
Sbjct: 937 NNVSQIKLMHTKIDELRTLDS-VSQISNIDLLNLRDLSNG---SEEDNL----------- 981
Query: 617 TSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGI-VIFNTTDTMINIEGKRNDQD 675
D+ N L K++ K I+E ++N+++S I I+ ++ K++ Q
Sbjct: 982 -PNTQLDLLGNDYLVSKQV--KEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQ- 1037
Query: 676 YVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHEN 718
+ + + EV K E + EK H+N
Sbjct: 1038 -----------IEELEQQIEKLQAEVKGYKDENNRLKEKEHKN 1069
Score = 56.6 bits (135), Expect = 2e-07
Identities = 138/651 (21%), Positives = 264/651 (40%), Gaps = 122/651 (18%)
Query: 6 AKLKAEI-EAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRS 64
AKL+ +I E E L + KE E S + D + ++L E + N +++
Sbjct: 1141 AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
Query: 65 KAV---EELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEE 121
+ EE + ++T+ L A S +L+ L + EE L + L++ +K+
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRK-EEDYADLKEKLTDAKKQI 1259
Query: 122 FMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKEL 181
K D +D + E+E+K Q + KQ+ +
Sbjct: 1260 KQVQKEVSVMRD------------------EDKLLRIKINELEKKKNQCSQELDMKQRTI 1301
Query: 182 EDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLEN----IQKQEQDKMNDELY 237
Q LK Q + ++ + ++ +R C K V++K +E+ +++QEQ ++ +
Sbjct: 1302 -----QQLKEQLNNQKVEEAIQQYERAC--KDLNVKEKIIEDMRMTLEEQEQTQVEQDQV 1354
Query: 238 KEEKIWK-EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKA 296
E K+ + E+ E + +E + + +++ + +L + N ++Q +
Sbjct: 1355 LEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQK 1414
Query: 297 FVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEE 356
+ A +K K + ++ ++A+ + KE K K E+R+R ++Q E Q E+
Sbjct: 1415 YNADRKKWLEEKMMLITQAKEAENIRNKEMK---KYAEDRERFFKQQNEMEILTAQLTEK 1471
Query: 357 RKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS 416
+K ++ER+QL++ +I L+ +ISS ++K +N+ L+ I
Sbjct: 1472 DSDLQK--------WREERDQLVAALEIQLK------ALISSNVQK---DNEIEQLKRII 1514
Query: 417 NDKGDIAKNLVD---------ENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKE 467
++ I ++D + K Q + L E S K ++ +++ +S +V +
Sbjct: 1515 SETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNK--IEDGSVVLDSCEVSTEN 1572
Query: 468 SISSQ----------TILADFKMEEKNENL----------AKKRCSEELVKQERKYENTD 507
S++ T L KM K+ A+KR S E+ + K EN
Sbjct: 1573 DQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKK 1632
Query: 508 NKTELGNSDLKGNLKEQFPL-QELKSDAQKEEKI----------------------MKHV 544
N T + NLK FP+ + S +KE+K+ +
Sbjct: 1633 NATP------RTNLK--FPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATK 1684
Query: 545 INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE--KEEIQE 593
E T QK L H+ I + K +KII+ K+ VE KE + +
Sbjct: 1685 KKEGTLQKFGDFLQHSPSILQSKA---KKIIETMSSSKLSNVEASKENVSQ 1732
Score = 48.1 bits (113), Expect = 7e-05
Identities = 108/510 (21%), Positives = 203/510 (39%), Gaps = 71/510 (13%)
Query: 5 DAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINI-IKNR 63
D +K +I ++ ++++ E+ +E D E + ++ + + EL + C ++ KN
Sbjct: 1326 DLNVKEKIIEDM-RMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN 1384
Query: 64 SKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEK--EE 121
++ +E +TD+L G ++N L E +ES + K ++ +K EE
Sbjct: 1385 QRSNKE----HENNTDVL----GKLTN--------LQDELQESEQ---KYNADRKKWLEE 1425
Query: 122 FMRSKTDCATPDFVPEPSPHDLPMD-EHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKE 180
M T + + D E ++ ++ EK + W+E++ +
Sbjct: 1426 KMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEK-DSDLQKWREERDQ 1484
Query: 181 LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK----KLENIQKQEQDKMNDE- 235
L + LKA ++ E E+ + + K+E + K + I + DK+ E
Sbjct: 1485 LVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEP 1544
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
L +I + K + + + + E +++ + E E Q N AVK
Sbjct: 1545 LSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTT 1604
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEE 355
P+ + +++KRK+ E EE +K E KK
Sbjct: 1605 ---------PVTVKIPKARKRKSNEM-------------------EEDLVKCENKKNATP 1636
Query: 356 ERKRREKEYEEKKNIVKQEREQLI---SKEKIILREDASQQLIISSALKKSGYNNKHLS- 411
+ +++ + VK+E++ I SK+ LR AS + + KK G K
Sbjct: 1637 RTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDF 1696
Query: 412 LEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESI---QVKLKES 468
L+ + AK +++ S + L VE S KENV + K + ++
Sbjct: 1697 LQHSPSILQSKAKKIIETMSSSK----LSNVEAS--KENVSQPKRAKRKLYTSEISSPID 1750
Query: 469 ISSQTILADFKMEEKNENLAKKRCSEELVK 498
IS Q IL D KM+E + + K+R + K
Sbjct: 1751 ISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
Score = 45.4 bits (106), Expect = 5e-04
Identities = 92/416 (22%), Positives = 183/416 (43%), Gaps = 51/416 (12%)
Query: 259 LQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKA 318
L +E+ + E+ +N K + K + KAF+++++ ++ + KK+
Sbjct: 529 LMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLI 588
Query: 319 QEWKEK---EAKIRQK--EEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQ 373
E KEK E KIR++ +E + + E KE +++E + E+ K++V
Sbjct: 589 NEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLV-- 646
Query: 374 EREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLE----DISNDKGDIAKNLVDE 429
K RE+A++ + + + L +++ KG++ K E
Sbjct: 647 --------GKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIK--TKE 696
Query: 430 NSKKQE---DVLLWLVEESNMKENVDRQTILKESIQV--KLKESISSQTILAD-----FK 479
KK+E D L+ +E SN K Q I KE I + + +++I+ L FK
Sbjct: 697 ELKKRENESDSLIQELETSNKKIITQNQRI-KELINIIDQKEDTINEFQNLKSHMENTFK 755
Query: 480 MEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEK 539
+K + + + +L+ E D+K+++ + + N E LQ+ + A+K
Sbjct: 756 CNDKADT-SSLIINNKLICNETVEVPKDSKSKICSERKRVNENE---LQQDEPPAKKGSI 811
Query: 540 IMKHVINENTGQKTQIILGHNQEISEVKTNEEQK-------IIKDNQQKKIQKVEKEEIQ 592
+ I E+ +K++ + + EI +++ +E + +N+ K EKEE
Sbjct: 812 HVSSAITEDQ-KKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKN----EKEEKA 866
Query: 593 EQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIY-SKSKEIEENPK 647
E N + + L +S K ++L+L+ E + ++ N + E++ KSK E+ K
Sbjct: 867 ELNKQIVHFQQELSLSEK-KNLTLSKE-VQQIQSNYDIAIAELHVQKSKNQEQEEK 920
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 88.2 bits (217), Expect = 6e-17
Identities = 157/755 (20%), Positives = 329/755 (43%), Gaps = 128/755 (16%)
Query: 5 DAKLKAEIEAELDKLSISSLE-KEDIESDAKS----ETQSDDSDTDSVELPESVLHCI-N 58
D+ A IE E +L+ E +E+I+S K +T + + +L E + +
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 59 IIKNRSKAVEELILQ--DLEDTDILSCSYGAVSNNHMHLRT-----GLSTEYEESSEQLI 111
I +++SK + L ++ D E T I+S + LR GLS +ES +++
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438
Query: 112 KILSEIEK----EEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYC---EVE 164
+ E + +E ++S++D + + H L + ++ +C E E
Sbjct: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH--------LETEEELKVAHCCLKEQE 1490
Query: 165 EKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCW-MKQF-KVEKKKLE 222
E + EK+ E+ +KQ L+A D+ + + QE EK + +KQ +V++K E
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
Query: 223 NIQKQEQDKMNDELYK--EEKIWK--EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNS 278
Q +E K D + E K+ + + ++ +E I+ + ++ +EE R ++ + E++
Sbjct: 1550 LKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ-IMIKEKEEMKRVQEALQIERDQ 1608
Query: 279 LLKQQNNAAVKIQAKYKAFVAYQKYGPI------------IKEQIESKKRKAQEWKEKEA 326
L + K++ + + K + +KEQ E++K + + +
Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668
Query: 327 KIRQ-------------KEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVK- 372
++ Q KE ++ + +EE +++ ++ K+ E R+ E +E+ IV
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 373 --QEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDEN 430
+E ++ I K + I+ E ++ IS+ K ++N L +D+ + ++ +
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTNE---ISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785
Query: 431 SKKQEDVLLWLVEE-----SNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNE 485
++ D L +V E SNM+++++ +Q K++E +++ L K ++ NE
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNA---KLQEKIQELKANEHQLITLK-KDVNE 1841
Query: 486 NLAKKRCSEELVKQERKYENTDNKTELGN-----------SDLKGNLKEQFPLQELKSDA 534
K E+L KQ + T +K E+ N ++K +KE+ L+ ++
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETL 1901
Query: 535 QKEEKIMKHVINENTGQ--------KTQIILG--HNQEISEVKTNEEQKII--------- 575
+ E +K + E + KT +L H + + +++ +K I
Sbjct: 1902 KLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 576 ---KDNQQKKIQKVEKEEIQ------------------EQNGLLYKDKDTLVISVKQRSL 614
KD QKKIQ+++K+E+Q EQ ++ ++ + SV+ +
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF 2021
Query: 615 SLTSENSKDVRE-NVILQEKEIYSKSKEIEENPKD 648
LT + + + E ++ +E++ + KE + +D
Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRRIKESLKMERD 2056
Score = 78.6 bits (192), Expect = 5e-14
Identities = 143/713 (20%), Positives = 306/713 (42%), Gaps = 133/713 (18%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E+ + + + + +D+E KS T+ + + + + +L + + + + EL
Sbjct: 1253 ELRRSVSEKTAQIINTQDLE---KSHTKLQE-EIPVLHEEQELLPNVKEVSETQETMNEL 1308
Query: 71 ILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCA 130
L + T S + + + L + +++ES E++ + E + + ++ +
Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRL----NEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 131 TPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLK 190
HD + EH+ A I Q ++ QE+ +++K+ +T K
Sbjct: 1365 ----------HD-QLKEHIRETLAKI------------QESQSKQEQSLNMKEKDNETTK 1401
Query: 191 AQRDREE-------------------KQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDK 231
+ E+ K+ QE ++ K+ K + ++L+ + + E D+
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-KDDLQRLQEVLQSESDQ 1460
Query: 232 MND----------ELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQ--------- 272
+ + E +E K+ K+ EE I L + + E+ T Q
Sbjct: 1461 LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK 1520
Query: 273 ---------EKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKK----RKAQ 319
EKE+ +KQ + K+ + K F ++K + IESK + Q
Sbjct: 1521 LQNKIQEIYEKEEQFNIKQISEVQEKVN-ELKQFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Query: 320 EWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEE-----RKRREKEYEEKKNIVKQE 374
E +E E +I KE+E KR++E +I+ ++ K+ +E ++ +EKEY+ K E
Sbjct: 1580 ESQE-EIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 375 REQLISKEKIILREDASQQL----IISSALKKSGYNNKHL-SLEDISNDKGDIAKNLVDE 429
++ + + + + + +Q+L I + ++ + +++L + ++ ++ D+ V+E
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS--VEE 1696
Query: 430 NSKKQEDVLLWLVEESNMKENVDRQTILKESIQV---KLKESISSQTILADFKMEEKNE- 485
K + D L + N++E + R +E +++ LKE + L E+ NE
Sbjct: 1697 TLKVERDQL-----KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI 1751
Query: 486 -NLAK--KRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK 542
N+ K + ++ L Q+ K + + + + LK + L+ + S+ + M+
Sbjct: 1752 SNMQKDLEHSNDALKAQDLKIQ---EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQ 1808
Query: 543 HVINENTGQKTQIILGHNQEISEVKTNEEQKII--KD--NQQKKIQKVE--KEEIQEQNG 596
+ EN+ K Q ++I E+K NE Q I KD QKK+ ++E K++I++Q+
Sbjct: 1809 KDL-ENSNAKLQ------EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 597 LLYK-DKDTLVISVK-------QRSLSLTSENSKDVRENVILQEKEIYSKSKE 641
L K + + L ++ K +S+ +N + V E + L+ ++ +E
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Score = 77.8 bits (190), Expect = 8e-14
Identities = 141/650 (21%), Positives = 282/650 (43%), Gaps = 123/650 (18%)
Query: 179 KELEDKEKQTLKAQRDREE--KQFQEEEEKRHCWMKQFKVEKK-KLENIQKQEQDKMNDE 235
++LE++ ++ R++E+ K+ QE + + ++ K++ LE+I+ +Q M
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQK--LENIKMDLSYSLESIEDPKQ--MKQT 626
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
L+ E + + K+ ++R+ +L+++E+ ++ +N + Q+ +++AK K
Sbjct: 627 LFDAETVALDA-KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS----QLEAKKK 681
Query: 296 AFVAYQK-----YGPIIK--EQIESKKRKAQEWK-EKEAKIRQKEEENRKRLEEEQRIKE 347
V +K + I K I+ K K E E KI ++E K +EE + ++E
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
Query: 348 E-------RKKQKEEERKRRE-KEYEEKKNIVKQEREQLISKEKIILREDASQQLI---- 395
E + E ER R+E ++ E+ +I+ E+++L S +++ +E Q L+
Sbjct: 742 EVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS--EVVHKESRVQGLLEEIG 799
Query: 396 ---ISSALKKSGYNNKHLSLEDISNDKGDIA---KNLVDENSK----------------- 432
A +S Y + ++ D K +++EN +
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859
Query: 433 ------------------KQEDVLLWLVEESNMKENVDR-----QTILKES--IQVKLKE 467
K +V L E +KE ++ QT+ +E I KL++
Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919
Query: 468 SISSQTILADFK--MEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQF 525
++ L K +++ E+L +R + + N D + +L N+ L+ + Q
Sbjct: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA-LESLKQHQE 978
Query: 526 PLQELKSDAQKEEKIMKHVINENTG------QKTQIILGHNQEISEVKTNEEQKIIKDN- 578
+ LKS +E H + ENTG Q+ + + Q++ T +KDN
Sbjct: 979 TINTLKSKISEEVSRNLH-MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNE 1037
Query: 579 ---QQKKIQKV--EKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEK 633
QQ+KI + EK E+Q+ + +K+ L +K+ ++ +T EN +++R +L ++
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE-NIEMTIENQEELR---LLGDE 1093
Query: 634 EIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAE 693
K +EI K++A + T D + +E K ++ L + L N E
Sbjct: 1094 --LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ--QQLLNVQEE 1149
Query: 694 SSMVSKEVN---SLKSEIRN--------------ISEKCHENAPEPDSMT 726
S + K++N +LK+E++N +++K +EN E S+T
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Score = 70.9 bits (172), Expect = 1e-11
Identities = 167/870 (19%), Positives = 344/870 (39%), Gaps = 155/870 (17%)
Query: 7 KLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKA 66
KL + I+ ++ K + +LE E +D + E + + +++ +L + + + +
Sbjct: 699 KLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVER 758
Query: 67 VEELILQDLEDTDILSCSYGAVSNNHMHLRT---GLSTEYEESSEQLIKILSEIEK--EE 121
+ + I E+ I++ + + +H + GL E ++ + L S + +E
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818
Query: 122 FMRSKTDCATPDF-----------------VPEPSPHDLPMDEHVLPDDADINFGYCEVE 164
F KT DF + S D + ++++ E++
Sbjct: 819 FQNFKT--LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876
Query: 165 EKCRQSFEAWQEKQK---ELEDKEKQTLKAQRDR------------EEKQFQEEEEKRHC 209
EK R+ E E ++ +LE+++ +R++ E K +E++
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 210 WMKQFKVEKKKLE---------NIQKQEQDKMNDELYKE--EKIWKEKFKQHEEYIRNLH 258
+ ++E+ +L+ NI QEQ + E K+ E I K K EE RNLH
Sbjct: 937 LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 259 LQMEEERTRFKDQQEK---EKNSLLKQQNNAAVKIQAKYKAFVAYQ-KYGPIIKEQIESK 314
++ T+ + QQ+ +K L+ +N + K + Q K +I+E+ E +
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 315 KRKAQEWKEKEAKIRQKEEENRKRLEEEQRIK---EERKKQKE----------------- 354
+ EKE +E +E ++ ++ +E KKQ+E
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 355 ----------EERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG 404
E+ K + ++ +EK+ + +E++ +K I + + L K+
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI---NEIENL-------KNE 1166
Query: 405 YNNKHLSLEDISNDKGDIAKNLVD-----ENSKKQEDVLLWLVEESNMKENVDRQTILK- 458
NK L+LE + ++ ++A+ L + ++ K+ VL L + + + R I +
Sbjct: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226
Query: 459 ESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLK 518
E+ ++ KE + +A ++E E + + R S K N +L S K
Sbjct: 1227 EATGLQTKEELK----IAHIHLKEHQETIDELRRS-----VSEKTAQIINTQDLEKSHTK 1277
Query: 519 GNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDN 578
L+E+ P+ +E++++ +V + Q+T + + ++E T ++ +
Sbjct: 1278 --LQEEIPV------LHEEQELLPNVKEVSETQET---MNELELLTEQSTTKDSTTLARI 1326
Query: 579 QQKKIQKVEK-EEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYS 637
+ ++++ EK +E QE+ L K++D L ++K+ + + +RE + ++
Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLK-TIKEALEVKHDQLKEHIRETLAKIQESQSK 1385
Query: 638 KSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAES--- 694
+ + + KDN TT + +E + +L GLS ES
Sbjct: 1386 QEQSLNMKEKDN---------ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 695 ---------------SMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSE-----STL 734
++ E + LK I+ I K E E CC+ E + L
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 735 LYSIEERRLAWIKSFKPWLEIFKQNQQKKI 764
++ E+ I + + LE Q KI
Sbjct: 1497 RVNLSEKETE-ISTIQKQLEAINDKLQNKI 1525
Score = 45.4 bits (106), Expect = 5e-04
Identities = 95/445 (21%), Positives = 174/445 (39%), Gaps = 58/445 (13%)
Query: 308 KEQIESKKRKAQEWKEKEA--KIRQKEEENRKR-------LEEEQRIKEERKKQKE---- 354
+ Q K + AQ +EK+ K++ ++ EN R L +Q +K +RK++
Sbjct: 367 RAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLG 426
Query: 355 EERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLED 414
+ K + Y ++ NI + +LRE I S +S + +L+
Sbjct: 427 KINKMKNSNYADQFNIPTNITTKTHKLSINLLRE------IDESVCSESDVFSN--TLDT 478
Query: 415 ISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTI 474
+S + + A L+++ + + E L + N+ + ++ KE +++KLKE
Sbjct: 479 LSEIEWNPATKLLNQENIESELNSL-RADYDNLVLDYEQLRTEKEEMELKLKEK------ 531
Query: 475 LADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDA 534
D E E KK +L+ + +N E+ N DL+ L + L K D
Sbjct: 532 -NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQ 590
Query: 535 QKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQ 594
K+ ++ I+ + ++ L ++ E E +Q + K E ++ +
Sbjct: 591 IKK---LQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSE 647
Query: 595 NGLLYKDKDTLVISVKQ--RSLSLTSENSKDVRENVILQEKEIYSKSKEIE--------E 644
N L + L + KQ + L + ++ + EKE+ S EI +
Sbjct: 648 NLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 707
Query: 645 NPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHA-PCEGLSN---YNAESSMVSKE 700
PKD N + +EGK D L + E L +E + E
Sbjct: 708 VPKDLLCN------------LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSE 755
Query: 701 VNSLKSEIRNISEKCHENAPEPDSM 725
V L+ EI++ SE+ H E D +
Sbjct: 756 VERLRKEIQDKSEELHIITSEKDKL 780
Score = 42.7 bits (99), Expect = 0.003
Identities = 91/461 (19%), Positives = 183/461 (39%), Gaps = 61/461 (13%)
Query: 7 KLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKA 66
K+K E ++K + +++ + + + + Q D D +P L + + +N
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD---VPSRELRDLKLNQNMDLH 2238
Query: 67 VEELILQDLEDTDI--LSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMR 124
+EE IL+D +++ + + V +N + T E+ + + K+ + I+KE
Sbjct: 2239 IEE-ILKDFSESEFPSIKTEFQQVLSNRKEM-TQFLEEWLNTRFDIEKLKNGIQKE---- 2292
Query: 125 SKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDK 184
+ C +F + ++ I E EE+ + W++ K L++K
Sbjct: 2293 NDRICQVNNF----------FNNRIIA----IMNESTEFEERSATISKEWEQDLKSLKEK 2338
Query: 185 EK------QTLKAQ--RDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDEL 236
+ QTLK + ++ + H + ++ +K+ ++ + +
Sbjct: 2339 NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAM 2398
Query: 237 YKEEKIWK--EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKY 294
+KE KI K ++ + + I L ++ E EK K ++ Q+ A+ + Y
Sbjct: 2399 HKESKIIKMQKELEVTNDIIAKLQAKVHESNKCL----EKTKETIQVLQDKVALGAK-PY 2453
Query: 295 KAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKE 354
K + K ++K +E K + A+E+ EKE + E +K + R R +Q +
Sbjct: 2454 KEEIEDLKM-KLVKIDLE-KMKNAKEF-EKEISATKATVEYQKEVIRLLRENLRRSQQAQ 2510
Query: 355 EERKRREKEYEEKKN----------IVKQEREQLISKEKIILREDASQQLIISSALKKSG 404
+ E + N IV+ + ++ E I L ++ S+ + L K
Sbjct: 2511 DTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQK 2570
Query: 405 ----YNNKHLSLE----DISNDKGDIAKNLVDENSKKQEDV 437
NN+HLS E K + K + ENS K V
Sbjct: 2571 NELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKV 2611
Score = 38.5 bits (88), Expect = 0.057
Identities = 95/470 (20%), Positives = 193/470 (41%), Gaps = 53/470 (11%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL-ENIQKQEQDKMN 233
+E+ + + E + ++E + + ++ C + ++ KL +N+ ++ +
Sbjct: 2185 EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 234 DELYKEEKIWKEKFKQHEEYIRNLHLQMEEE-RTRFKDQQEKEKNSLLKQQNNAAVKIQA 292
D E K +F+Q + + +EE TRF EK KN + K+ +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF--DIEKLKNGIQKENDRICQVNNF 2302
Query: 293 KYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIK------ 346
+A I+ E E ++R A KE E ++ +E+N K + Q +K
Sbjct: 2303 FNNRIIA------IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASG 2356
Query: 347 -------EERKKQKEEERKRR--EKEYEEKKNIVKQEREQLISKEKIILREDASQQL--- 394
++ K R + ++ E +N + + +E + KE I++ ++
Sbjct: 2357 AQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTND 2416
Query: 395 IISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQ 454
II+ K +NK L + + + + ++ V +K ++ E ++K + +
Sbjct: 2417 IIAKLQAKVHESNKCL---EKTKETIQVLQDKVALGAKPYKE------EIEDLKMKLVKI 2467
Query: 455 TILKESIQVKLKESISSQTILADFKMEE---KNENLAKKRCSEEL-VKQERKYENTDNK- 509
+ K + ++ IS+ +++ E ENL + + +++ V E NK
Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
Query: 510 -TELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTG---QKTQIILGHNQEIS- 564
T G S + N K LKS+ + EK + + +N QK ++ L +NQ +S
Sbjct: 2528 LTCGGGSGIVQNTKALI----LKSEHIRLEKEISKLKQQNEQLIKQKNEL-LSNNQHLSN 2582
Query: 565 EVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL 614
EVKT +E + +K K++ + + G K K K+R+L
Sbjct: 2583 EVKTWKE-RTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNL 2631
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 86.3 bits (212), Expect = 2e-16
Identities = 153/795 (19%), Positives = 325/795 (40%), Gaps = 94/795 (11%)
Query: 2 DDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDS----DTDSVELPESVLHCI 57
+++ AK A+I + ++ IS LE E ++ + K+ + + + D ++ +L + +
Sbjct: 1018 EEEKAKNLAKIRNK-QEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL- 1074
Query: 58 NIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEI 117
++EL LQ + + L + + +H L E Q+ ++ +
Sbjct: 1075 ------QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAELQEDF 1127
Query: 118 EKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEK 177
E E+ R+K + D E L + L D D E+ K Q ++
Sbjct: 1128 ESEKASRNKAEKQKRDLSEE-----LEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 178 QKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELY 237
+E + ++ R R +E E+ ++Q K K LE KQ + N EL
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQ----LEQAKRFKANLEK-NKQGLETDNKELA 1237
Query: 238 KEEKIWKEKFKQHEEYIRNLHLQMEE------ERTRFKDQQEKEKNSLLKQQNNAAVKIQ 291
E K+ ++ + E + L Q++E E R + + ++ + L + +N + ++
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 292 AKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK 351
K + + K ++ Q++ QE ++E + + ++LEEE+ +E+++
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQD----TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 352 QKEEERKRREKEY--------EEKKNI--------VKQEREQLISKEKIILREDASQQLI 395
++EE RK EK+ + KK + +E ++ + K+ L + ++ +
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 396 ISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM-------K 448
L+K+ N L+D++ D D + + KKQ+ L EE ++ +
Sbjct: 1414 AYDKLEKT-KNRLQQELDDLTVDL-DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 449 ENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDN 508
+ + + KE+ + L ++ + + A + E +N+ L + E+L+ + +
Sbjct: 1472 DRAEAEAREKETKALSLARAL-EEALEAKEEFERQNKQL--RADMEDLMSSKDDVGKNVH 1528
Query: 509 KTELGNSDLKGNLKE-QFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 567
+ E L+ ++E + L+EL+ + Q E + K Q + +
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF---ERDLQTRDE 1585
Query: 568 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 627
NEE+K + Q ++++ E E+ ++Q L K + I +K + + N R+
Sbjct: 1586 QNEEKKRLLIKQVRELE-AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK--ARDE 1642
Query: 628 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCE-G 686
VI Q +++ ++ K+ + +E R +D + + E
Sbjct: 1643 VIKQLRKLQAQMKDYQR---------------------ELEEARASRDEIFAQSKESEKK 1681
Query: 687 LSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWI 746
L + AE + +E+ S + R+ ++ E A D +T S + L + R A I
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELA---DEITNSASGKSALLDEKRRLEARI 1738
Query: 747 KSFKPWLEIFKQNQQ 761
+ LE + N +
Sbjct: 1739 AQLEEELEEEQSNME 1753
Score = 80.9 bits (198), Expect = 1e-14
Identities = 150/724 (20%), Positives = 297/724 (41%), Gaps = 116/724 (16%)
Query: 7 KLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKA 66
K+ E++A++ +L +ED ES+ S +++ D E E++ + + + A
Sbjct: 1111 KVVRELQAQIAEL------QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA 1164
Query: 67 VEELILQDLEDTDILSCSYGAVSNNH----MHLRTGLSTEYEESSEQL------------ 110
+EL + ++ L + + NH +R +T EE SEQL
Sbjct: 1165 QQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 111 ---------------IKILSEIEKE-EFMRSKTDCATPDFVPEPSPHD-----LPMDEHV 149
+K+L +++ E E R K D + + S D L
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284
Query: 150 LPDDADINFGYCEVEEKCRQSF--------EAWQEKQKELEDKEKQTLKA-----QRDRE 196
L ++ D E EK F Q+ Q+ L+++ +Q L Q + E
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 197 EKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRN 256
+ QE++E+ K + + L++ + K++D+L E + + K K ++
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD-AEA 1403
Query: 257 LHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKI----QAKYKAFVAYQKYGPIIKEQIE 312
L ++EE+ + D+ EK KN L ++ ++ V + Q +K+ ++ E+
Sbjct: 1404 LSQRLEEKALAY-DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 313 SKKRKAQEWKEKEAKIRQKEEEN---RKRLEEEQRIKEERKKQKEEERKRREK------- 362
R A+E EA+ R+KE + + LEE KEE ++Q ++ R E
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522
Query: 363 ------EYEEKKNIVKQEREQLISK-----EKIILREDASQQLIISSALKKSGYNNKHLS 411
E E+ K ++Q+ E++ ++ +++ EDA +L ++ K+ + +
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 412 LEDISNDKGDIAKNLVDENSKKQEDVLLW--LVEESNMKENVDRQTILKESIQV--KLKE 467
++ + +K + V E + ED L S K +D + L+ I+ K ++
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD-LEAQIEAANKARD 1641
Query: 468 SISSQTILADFKMEEKNENLAKKRCS-EELVKQERKYENTDNKTELGNSDLKGNLKEQFP 526
+ Q +M++ L + R S +E+ Q ++ E LK E
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK----------LKSLEAEILQ 1691
Query: 527 LQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKV 586
LQE + +++ + + +E + T G + + E K + +I ++
Sbjct: 1692 LQEELASSERARRHAEQERDELADEITNSASGKSALLDE----------KRRLEARIAQL 1741
Query: 587 EKEEIQEQNGL-LYKD---KDTLVISVKQRSLSL---TSENSKDVRENVILQEKEIYSKS 639
E+E +EQ+ + L D K TL + L+ ++ S + R+ + Q KE+ +K
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801
Query: 640 KEIE 643
+E+E
Sbjct: 1802 QELE 1805
Score = 70.9 bits (172), Expect = 1e-11
Identities = 112/538 (20%), Positives = 242/538 (44%), Gaps = 74/538 (13%)
Query: 175 QEKQKELED------KEKQT-LKAQRDREEKQFQEEEEKRHCWMKQFKVE---------- 217
QE++ + +D KEKQT ++ + + E++ Q+ E+++ +Q + E
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 218 -------KKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQM-EEERTRFK 269
K++LE I + ++ +E + + + EK K+ + +I++L Q+ EEE R K
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEK-KKMQAHIQDLEEQLDEEEGARQK 968
Query: 270 DQQEK-EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKI 328
Q EK + +K+ + ++ + F+ +K + S+ + +E + AKI
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 329 RQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYE---------EKKNIVKQEREQLI 379
R K+E LEE R+K+E K ++E E+ +R+ + E E + + + + QL
Sbjct: 1029 RNKQEVMISDLEE--RLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 380 SKEKII---LREDASQQLIISSALKKSGYNNKHLS--LEDISNDKGDIAKNLVDENSKKQ 434
KE+ + L + L ++ALK ++ ED ++K K + +
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146
Query: 435 EDVLLWLVEESNMKENVDRQTI--LKESIQVKLKESISSQTILADFKMEEKNEN--LAKK 490
E L E + +Q + +E +LK+++ +T + ++++ + A +
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE 1206
Query: 491 RCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINE--- 547
SE+L + +R N + + +D K E LQ++K++++ + K + + E
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266
Query: 548 --NTGQKTQIILGH-----NQEISEVKT---NEEQKIIK--------DNQQKKIQKVEKE 589
+ G + ++ L E+ V T E+K IK ++Q + Q++ +E
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326
Query: 590 EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPK 647
E +++ L + + + ++ SL E ++ R+N+ EK++ + ++ + K
Sbjct: 1327 ETRQKLNLSSRIRQ---LEEEKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKK 1378
Score = 68.2 bits (165), Expect = 7e-11
Identities = 132/687 (19%), Positives = 292/687 (42%), Gaps = 106/687 (15%)
Query: 5 DAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRS 64
+ +L AE E +L+ E E+I D +S + ++ I++N
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ-------------ILQNEK 945
Query: 65 KAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMR 124
K ++ I QDLE+ L GA R L E + ++ K+ EI E
Sbjct: 946 KKMQAHI-QDLEEQ--LDEEEGA--------RQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 125 SKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDK 184
SK F+ E M++ + A+ + E EEK + + +++ + D
Sbjct: 995 SK-------FIKEKKL----MEDRI----AECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 185 EKQTLKAQRDREEKQ------------FQEEEEKRHCWMKQFKVE-KKKLENIQKQEQDK 231
E++ K ++ R+E + Q++ + + + K++ KK E +Q
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 232 MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQ 291
++ L+K + + ++ + I L E E+ +++ EK+K L ++ +++
Sbjct: 1100 DDETLHKNNAL--KVVRELQAQIAELQEDFESEKAS-RNKAEKQKRDLSEELEALKTELE 1156
Query: 292 AKYKAFVAYQKYGPIIKEQI-ESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERK 350
A Q+ ++++ E KK +E K EA+I+ + + LEE
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE--------L 1208
Query: 351 KQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHL 410
++ E+ KR + E+ K ++ + ++L + K++ QQ+ S K+ + +
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL------QQVKAESEHKRKKLDAQVQ 1262
Query: 411 SLEDISNDKGDIAKNLVDENSKKQE--DVLLWLVEESNMK-------------ENVDRQT 455
L ++ + L ++ SK Q D + L+EE+ K + D Q
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 456 ILKESIQVKLKESISSQTILAD---FKMEEKNENLAKKRCSEELVKQERKYENTDNKT-- 510
+L+E + KL S + + + + +++ E A+K ++++ + + +T K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 511 ELGNSDLKGNLKEQFPLQELKSDAQK-EEKIMKHVINENTGQKTQIILGHNQEISEVKTN 569
+LG + K++ L++ ++ +Q+ EEK + + E T + Q QE+ ++ +
Sbjct: 1383 DLGTIESLEEAKKKL-LKDAEALSQRLEEKALAYDKLEKTKNRLQ------QELDDLTVD 1435
Query: 570 -EEQKIIKDNQQKKIQKVEKEEIQEQ--NGLLYKDKDTLVISVKQR-----SLSLTSENS 621
+ Q+ + N +KK +K ++ +E+ + +++D +++ SL+ E +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 622 KDVRENVILQEKEIYSKSKEIEENPKD 648
+ +E Q K++ + +++ + D
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDD 1522
Score = 49.3 bits (116), Expect = 3e-05
Identities = 71/318 (22%), Positives = 137/318 (43%), Gaps = 52/318 (16%)
Query: 158 FGYCEVEEKCRQSFEAW-QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKV 216
F + EK +S EA + Q+EL E+ A+++R+E +E
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE--LADEITNSASGKSALLD 1729
Query: 217 EKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKD-----Q 271
EK++LE Q ++++ +E E + ++F++ + L+ ++ ER+ + Q
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELL-NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788
Query: 272 QEKEKNSLLK---QQNNAAVKIQAKYKAFVAYQKYGPI---------------------- 306
Q + +N LK Q+ AVK + K K G +
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848
Query: 307 --IKE---QIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRRE 361
+KE Q+E ++R A ++KE+ K + ++ +++LEE EE + R++ +
Sbjct: 1849 KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE----AEEEATRANASRRKLQ 1904
Query: 362 KEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHL---SLEDISND 418
+E ++ E + +S+E L+ + IS + +SG HL SLE +S+D
Sbjct: 1905 RELDD-----ATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLE-LSDD 1958
Query: 419 KGDIAKNLVDENSKKQED 436
+ + V+E Q +
Sbjct: 1959 DTESKTSDVNETQPPQSE 1976
Score = 41.6 bits (96), Expect = 0.007
Identities = 82/415 (19%), Positives = 181/415 (43%), Gaps = 54/415 (13%)
Query: 479 KMEEKNENLAKKRCSE-----ELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSD 533
+++ K+E L K + + EL + ERK++ + + L+ + +E+++
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 534 AQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQ---KVEKEE 590
+++ ++ ++ H+ E S V+ EE+ I N++KK+Q + +E+
Sbjct: 913 LAAKKQELEEIL-------------HDLE-SRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 591 IQEQNGLLYK---DKDTLVISVKQRS---LSLTSENSKDVRENVILQEK--EIYSKSKEI 642
+ E+ G K +K T +K+ L L +NSK ++E +++++ E S+ E
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 643 EENPKDNAWNSGIVIFNTTDTMI-NIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEV 701
EE K+ A I N + MI ++E + ++ R + + E++ + ++
Sbjct: 1019 EEKAKNLA-----KIRNKQEVMISDLEERLKKEEKT--RQELEKAKRKLDGETTDLQDQI 1071
Query: 702 NSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQ 761
L+++I + + + E + TL + L ++ + + +++ +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETL---HKNNALKVVRELQAQIAELQEDFE 1128
Query: 762 KKIVRRKRPVKCPANMTPALDKLEILRCGPWDTL------QQVTTVTFQDLPGCVLSTLA 815
+ R + K +++ ++LE L+ DTL Q++ T Q++ +
Sbjct: 1129 SEKASRNKAEKQKRDLS---EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 816 ECTN--LQFLSLRRCGLTSLHSLS-NCKKLKYIDAQ-ENHIEAIECENLENLCVV 866
E N Q +R+ T+L LS ++ K A E + + +E +N E C V
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 86.3 bits (212), Expect = 2e-16
Identities = 163/716 (22%), Positives = 303/716 (42%), Gaps = 128/716 (17%)
Query: 15 ELDKLSISSLEKEDIESDAKSETQSDDSDT-DSVELPES-VLHCINIIKNRSKAVEELIL 72
E+++L+ S L K ++E+ + ++T + T DSVE S +L + SK VE L
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 73 QDLEDTDILSCSYGAVSNNHMHLRTGLSTEYE---ESSEQLIKILSEIEKEEFMRSKTDC 129
+ +++ L +S + M + L E E+SE+ IKIL + E E ++ +
Sbjct: 513 EIVQEKQSLQNCQN-LSKDLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSL 570
Query: 130 ATPDFVP-EPSPHDLPMDEHVLPD---DADINFGYCEVEEK-CRQSFEAWQEKQKELEDK 184
+ E D+ + +L + + E E++ ++ E ++EK + E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 185 EKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQ--------KQEQDKMNDEL 236
E + +++ E Q + K C K+E + EN + K+ D +
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 237 YKEEKIWKEKFKQHEEYI---RNLH-----------LQMEEERTRFKDQQEKEKNSLLKQ 282
++ E + KE + EE + RN+ LQ+E + + +Q K+ LLK
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 283 QNNAAVKIQAKYKAF-VAYQKYGPIIK------EQIESK-----------KRKAQEWKEK 324
+++ Y+ + Q+ ++ +Q+ES+ ++ +E K
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 325 EAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYE------EKKNI-------- 370
++ Q E+EN K LE+E E+ KKQ E+E KR ++ E E+ N+
Sbjct: 807 SKRLEQLEKEN-KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 371 --------------------VKQEREQLIS------KEKIILREDASQQLIISSALKKSG 404
+++E ++L+ K + LRED ++S LK
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-----LVSEKLKTQQ 920
Query: 405 YNNKHLSLEDISNDKGDIAKN----LVDENSKKQEDVLLWLVEESNMKENVDRQTILKES 460
NN LE ++++ I N L DE S LL ES +K++++ + +
Sbjct: 921 MNN---DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 461 IQVKLKESIS-SQTILADFKMEEKNENLAKKRCSEE-LVKQERKYENTDNKTELGNSD-L 517
++ +L+ES + +Q + + K +KN K+R EE +V+ DNK E + +
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 518 KGNLKEQFPLQE-------LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNE 570
+ LK + L E L+++ Q + +K + +N + QI+ Q +S +
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS----LQ 1093
Query: 571 EQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRE 626
EQ Q K+Q VE + Q+ L L+I + SL +EN ++E
Sbjct: 1094 EQNTTLQTQNAKLQ-VENSTLNSQSTSLMNQNAQLLI----QQSSLENENESVIKE 1144
Score = 78.6 bits (192), Expect = 5e-14
Identities = 149/718 (20%), Positives = 293/718 (40%), Gaps = 141/718 (19%)
Query: 14 AELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELI-- 71
A DKL LEKE+++ AK + D D ++ E + + + + ++++E +
Sbjct: 372 ARSDKLH--ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 72 ---LQDLEDTDILS-CSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKT 127
L+ + T LS ++ + L + + E ++ L K + E+
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR--------- 480
Query: 128 DCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQ 187
T D V + L M++ + E+ ++ +QS + Q K+L ++ Q
Sbjct: 481 --TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-KQSLQNCQNLSKDLMKEKAQ 537
Query: 188 ---TLKAQRDREEKQFQ-EEEEKRH-----------------CWMKQFKVEKKKLENIQK 226
T++ R+ E+Q + E+E H +K + E K L K
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 227 QEQDKMND------ELYKEEKIWKEKFKQHEEYIRNL-HLQMEEER-----TRFKDQQEK 274
+ K++ ++ KE + +KEK ++ EE L HL+ E E T K EK
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 275 -----EKNSLLKQQNNAAVKIQAKYKAFV----AYQKYGPIIKEQIESKKRKAQEWKEKE 325
++NS L+++N K +K + +K + E+ +R + K
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 326 AKIRQKEEENRKRLEEEQRIKEE--------RKKQKEE--------ERKRREKEYEEKKN 369
K+ Q + EN++ E++++K+ +K ++ E E +R +K E
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 370 IVKQEREQL--ISKEKIILREDASQQLIISSALKKSGYNNKHLSLE--DISNDKGDIAKN 425
++Q +L + E L+++ + I S L++ NK L E + DK + K
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 426 LVDENSKKQEDVLLWLVEESNMK----------------------------ENVDRQTIL 457
++ ++Q ++ +EE+N+K E +++ +
Sbjct: 838 --NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 458 KESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELV--KQER---KYENTDNKTEL 512
+ +I +K ++ + K ++ N +L K E + +ER ++TD++ +L
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL 955
Query: 513 GNSDLKGNLKEQFPLQELKSDAQKEEKI--MKHVINENTGQKTQIILGHNQEISEVKTNE 570
S L+ LK+ + KEEKI ++ + E+T Q+ QE+ VK N
Sbjct: 956 LESKLESTLKKSLEI--------KEEKIAALEARLEESTNYNQQL----RQELKTVKKNY 1003
Query: 571 EQKIIKDNQQKKIQKVE---------KEEIQEQNGLLYKDKDTLVISVKQRSLSLTSE 619
E + ++++ +Q + E QE L K KD L I V++ + +L +E
Sbjct: 1004 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL-IEVERNNATLQAE 1060
Score = 72.8 bits (177), Expect = 3e-12
Identities = 134/670 (20%), Positives = 268/670 (40%), Gaps = 92/670 (13%)
Query: 99 LSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE-HVLPDDA--- 154
L E EE +EQL+ E+E+ E + + + + + DE L + A
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 155 ---------------DINFGYCEVEE-------------KCRQSFEAWQEKQKELEDKEK 186
DI F VEE E + + +L + EK
Sbjct: 323 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 187 QTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWK-- 244
+ L+ + + + + + +++ +++ E LE QKQ D+ ++ E+I +
Sbjct: 383 ENLQLKAKLHDMEMERDMDRKK--IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 245 ------EKFKQHE--EYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKA 296
+K HE E + L++E E E+ + ++ + NA+ KI K
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS-KILKMEKE 499
Query: 297 FVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK---QK 353
K I++ +I +K+ Q + + +++ + K +E + E + K Q+
Sbjct: 500 NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 354 EEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLE 413
E + ++ I + R + I KE IL E + SS L K + + + E
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE---TSSKLSKIEFEKRQIKKE 616
Query: 414 -DISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQ 472
+ +KG+ A+ L +E +++ L + +N+K ++ L++ +E+ +
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 473 TILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKS 532
L FK NL + S E + EN + + + + Q L+ +
Sbjct: 677 KTLDSFK------NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 533 DAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKE--E 590
+++KE+ + + + +KT+ + Q + +++ QK + +N KKIQ++E E +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGL-DIENQRLQKTL-ENSNKKIQQLESELQD 788
Query: 591 IQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQ--EKEIYSKSKEIEENPKD 648
++ +N L K+ + L IS K R L EN +E L+ +K++ ++K + + +
Sbjct: 789 LEMENQTLQKNLEELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE- 846
Query: 649 NAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEI 708
I +TT N++ + N E+ +SKE+ K
Sbjct: 847 --------IKDTTLEENNVK------------------IGNLEKENKTLSKEIGIYKESC 880
Query: 709 RNISEKCHEN 718
+ E EN
Sbjct: 881 VRLKELEKEN 890
Score = 64.3 bits (155), Expect = 1e-09
Identities = 114/530 (21%), Positives = 235/530 (44%), Gaps = 91/530 (17%)
Query: 172 EAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLE--------- 222
E+ Q EL D + + + +++ EEK Q + K+ ++Q ++E K+L+
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE--LEQMEIELKRLQQENMNLLSD 301
Query: 223 ----NIQKQEQDKMNDELYKEEKI------WKEK------FKQHEEYIRNLHLQMEEERT 266
+ + E D + ++ + +K+ +KE+ +K E ++ + + E +T
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 267 RFKDQQE--KEKNSLLKQQNNAAVKIQAK-----YKAFVAYQKYGPIIKEQIESKKRKAQ 319
+DQ E + ++ L + ++++AK + + +K +++E + + + Q
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 320 E--------WK-EKEAKIRQKEEENRKRL-EEEQRIKEERKKQKEEERKRREKEYEEKK- 368
W+ E+ ++ + E +K L E + R + E E + K EE +
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 369 ----------NIVKQERE-QLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISN 417
I+K E+E Q +SK+ IL + Q+ K+S N ++LS +D+
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-------KQSLQNCQNLS-KDLMK 533
Query: 418 DKGDIAKNL--VDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL 475
+K + K + + ENS++Q +L E+ N N QT+ ++ + IS++ +
Sbjct: 534 EKAQLEKTIETLRENSERQIKIL----EQENEHLN---QTV----SSLRQRSQISAEARV 582
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQ 535
D + E K + + K S +L K E +E K EL + KG E+ EL +
Sbjct: 583 KDIEKENKILHESIKETSSKLSKIE--FEKRQIKKELEHYKEKGERAEELE-NELHHLEK 639
Query: 536 KEEKIMKHVIN-ENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQ 594
+ E + K + N + T +K + + N E+ E +K+ K K + E ++++
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELE----RENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 595 NGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEE 644
N L D++ L + SL S ++ L+ KE+ S+ +++++
Sbjct: 696 NSQL--DEENLELRRNVESLKCASMKMAQLQ----LENKELESEKEQLKK 739
Score = 60.8 bits (146), Expect = 1e-08
Identities = 115/557 (20%), Positives = 235/557 (42%), Gaps = 52/557 (9%)
Query: 243 WKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQK 302
W E +E I L M R D++++ ++++ + + A
Sbjct: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
Query: 303 YGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREK 362
G ++ ES++ + E + +AKIR+ +E ++ E+ K+E +Q E E KR +
Sbjct: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQ- 292
Query: 363 EYEEKKNIVKQEREQLISKEKI-ILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGD 421
+E N++ R + ++++ LRE A + + S + S Y + L DI K
Sbjct: 293 --QENMNLLSDARSARMYRDELDALREKAVRVDKLESEV--SRYKER---LHDIEFYKAR 345
Query: 422 IAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKME 481
+ E K+ VL L ++ +++ ++ + + KE++ + L D +ME
Sbjct: 346 V------EELKEDNQVL--LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
Query: 482 EKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIM 541
+ ++ EEL+++ E ++ + L L++ EL QK +
Sbjct: 398 RDMD----RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS---L 450
Query: 542 KHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKD 601
H +NE T + + NQ ++ KT EE + D+ + K+ K ++++N L K
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLT--KTVEELRTTVDSVEGNASKILK--MEKENQRLSKK 506
Query: 602 KDTLVISVKQRSLSLTS--ENSKDVRENVILQEKEI----YSKSKEIEENPKDNAWNSGI 655
+ L + Q SL + SKD+ + EK I + ++I+ ++N +
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 656 VIFNTTDTMINIEGKRND---QDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNIS 712
V + I+ E + D ++ +L E + +++ S + E +K E+ +
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILH-----ESIKETSSKLSKIEFEKRQIKKELEHYK 621
Query: 713 EKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVK 772
EK + + E+ LL ++++ +K +E +Q + ++ R R +K
Sbjct: 622 EKGERAEELENELHHLEKENELL----QKKITNLKITCEKIEALEQ-ENSELERENRKLK 676
Query: 773 CP----ANMTPALDKLE 785
N+T L+ LE
Sbjct: 677 KTLDSFKNLTFQLESLE 693
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 85.5 bits (210), Expect = 4e-16
Identities = 121/539 (22%), Positives = 245/539 (45%), Gaps = 63/539 (11%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
E E++C + + ++E+ED + A ++ E+ +E + + V K
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 222 E---NIQKQEQDKMNDELYKEEKIWKEKFKQH-EEYIRNLHLQMEEERTRFKDQ---QEK 274
E N+QKQ ++ MN +L E++ KF+ + E+ ++ L ++E+ R F++Q +K
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQL---KFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
Query: 275 EKNSLLKQQNNAAVKIQAKYKAFVA-YQK-YGPIIKEQIESKKRKAQEWKEKEAKIRQKE 332
+ ++ ++ ++Q +A YQK + +E ++ K +E KE +I
Sbjct: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
Query: 333 EENRKRLEEEQRIKEERKKQKEEERKRREKEYE-EKKNIVK-----QEREQLISKEKIIL 386
+E+ + + +KE KQ E K +K+YE E +N+ K + Q+ S I+L
Sbjct: 264 KEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICS---ILL 320
Query: 387 REDASQQLIISSALKKSGYNNKHL-SLEDISNDKGDIAKNL-----VDENSKKQEDVLLW 440
+E+ + +++ +K K L S I D+ NL +D K E +
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDE----F 376
Query: 441 LVEESNMKENVDRQTILKES---IQVKLKESISSQTILADFKMEEKNENLAKKRCSEELV 497
E +++ ++ + KE + KLK ++ + +E+ N + + L
Sbjct: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREV------QSLK 430
Query: 498 KQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQK-EEKIMKHVINENTGQKTQII 556
+Q +K + N+T L +S+ K L F +Q LK + +++ + ++N + ++ I
Sbjct: 431 EQHQKEISELNETFLSDSE-KEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489
Query: 557 LGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSL 616
L S K ++E + +K Q + E+Q++ + +KD L+ +V + L
Sbjct: 490 LQTELGESAGKISQEFESMKQQQASDV-----HELQQKLRTAFTEKDALLETVNR----L 540
Query: 617 TSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTT--DTMI-NIEGKRN 672
EN K +L ++E+ E+E K+ +G+ + + + DTM+ +EGK N
Sbjct: 541 QGENEK------LLSQQELV---PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Score = 85.5 bits (210), Expect = 4e-16
Identities = 117/516 (22%), Positives = 240/516 (46%), Gaps = 54/516 (10%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
+VE+ + + E ++K EL ++TLK E+ Q ++ EK MK +K+ L
Sbjct: 630 KVEQTIQYNSEL-EQKVNELTGGLEETLK-----EKDQNDQKLEKLMVQMKVLSEDKEVL 683
Query: 222 ENIQK---QEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNS 278
K +E +K++ E + + + Q E+ I H+ E++ + +++ N
Sbjct: 684 SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743
Query: 279 LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKK--RKAQEWKEKEAKIRQKE---- 332
LL +N K+ K + + ++ G + E E K Q E AKI +++
Sbjct: 744 LL--ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA 801
Query: 333 -EENRKRLEEEQRIK--EERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILRED 389
+ + K LE E+ IK +E + EE K ++YE++K ++++E E+ I EK L+ D
Sbjct: 802 FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE-IQSEKEALQSD 860
Query: 390 ASQQLIISSALKKSGYNNKHL--SLEDISN--DKGDIAKNLVDENSKKQEDVLLWLVEES 445
L + +A +K+ N++L +E++S K +I N ++ K+ + L L+E+
Sbjct: 861 L---LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI-HNEKEKCFIKEHENLKPLLEQK 916
Query: 446 NMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEE---------- 495
+++ +LK+S+ S+ + + + ++EEK ENL +K C E+
Sbjct: 917 ELRDRRAELILLKDSL--AKSPSVKNDPLSSVKELEEKIENL-EKECKEKEEKINKIKLV 973
Query: 496 LVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQI 555
VK +++ +++ +T+ +L+ E+ L D + + K+++ E Q Q+
Sbjct: 974 AVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQL 1033
Query: 556 ILGHNQEISEVKTNEEQKIIKD-NQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL 614
++ + + N + I+D +Q + ++ E I N L +TL Q +
Sbjct: 1034 ------DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL-----QSNA 1082
Query: 615 SLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNA 650
L +V+ + +KE+ ++ + E+ K++A
Sbjct: 1083 KLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHA 1118
Score = 56.2 bits (134), Expect = 3e-07
Identities = 100/505 (19%), Positives = 208/505 (41%), Gaps = 82/505 (16%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL 221
+VE++ +FE +ED +Q + E E+ Q + ++
Sbjct: 1034 DVEKERANNFE------HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 1087
Query: 222 ENIQKQEQDKMNDELYKEEKIWKE-KFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLL 280
+ ++ Q M D+ + EK+ KE K K+H + L + Q +KEK L
Sbjct: 1088 QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE--------ELQVQLQKEKKQLQ 1139
Query: 281 K-QQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRL 339
K Q VK A+ + + I + K Q+ K KI E+E + +
Sbjct: 1140 KTMQELELVKKDAQQTTLMNME-----IADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 340 EEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSA 399
++++ ++EE + ++ EK + K+ +VK ++E SK+ + LI+ ++
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA------ETDHLILQAS 1248
Query: 400 LK------KSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDR 453
LK + + L +I+++K I ++L + S +Q L ++ R
Sbjct: 1249 LKGELEASQQQVEVYKIQLAEITSEKHKIHEHL--KTSAEQHQRTLSAYQQ--------R 1298
Query: 454 QTILKESIQVKLKESISSQTILADFKMEEKN-----ENLAKKRCSEELVKQER------- 501
T L+E + E + + +K+ N +N + + E KQER
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLI 1358
Query: 502 -----KYENTDNKTELGNSDLKGNLKEQFPLQE---------LKSDAQKEEKIMKHVINE 547
K +++ N ++ S+L+ E L E + +A+ EK+ + +E
Sbjct: 1359 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCS-IQSE 1417
Query: 548 NTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEE------IQEQNGLLYKD 601
N K++ H Q +S++ + E +++++ + +++ +++E +Q+Q +
Sbjct: 1418 NMMMKSE----HTQTVSQLTSQNE--VLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQ 1471
Query: 602 KDTLVISVKQRSLSLTSENSKDVRE 626
L RS + ++ K++RE
Sbjct: 1472 LFQLKNEPTTRSPVSSQQSLKNLRE 1496
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 85.5 bits (210), Expect = 4e-16
Identities = 91/431 (21%), Positives = 196/431 (45%), Gaps = 52/431 (12%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDE 235
E+ ++LE + L+ +R E + + EEE E+K+ E +++Q+++ + +
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEE-----------ERKRQEELRRQQEEILRRQ 766
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
+E K +E+ + L Q E+E + ++E+E+ +QQ A +++ + +
Sbjct: 767 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEER----QQQEEALRRLEERRR 822
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEE 355
+K ++++Q E +A +W +E + +++ EENR R+EEE R + +EE
Sbjct: 823 EEEERRKQEELLRKQEE----EAAKWAREEEEAQRRLEENRLRMEEE----AARLRHEEE 874
Query: 356 ERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG----------- 404
ERKR+E E + +K +++Q ++Q + + L++ QQ + L S
Sbjct: 875 ERKRKELEVQRQKELMRQRQQQQEALRR--LQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 932
Query: 405 YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVK 464
+ LSL +I + + + L +E ++Q +++ L ++ ++ K S
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ-------KLSGWGN 985
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNK--TELGNSDLKGNLK 522
+ + + L + + EE + +++ ++ + R NT + T +GNS + G++
Sbjct: 986 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNS-VWGSIN 1044
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQII--LGHNQEISEVKTN---EEQKIIKD 577
P + SD N N G + +G ++ K N + + +
Sbjct: 1045 TG-PPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSN 1103
Query: 578 NQQKKIQKVEK 588
Q KK+++ EK
Sbjct: 1104 RQNKKVEEEEK 1114
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/311 (22%), Positives = 153/311 (49%), Gaps = 26/311 (8%)
Query: 304 GPIIKE--QIESKKRKAQEWKEKEAKIRQK-EEENRKRLEEEQRIKEE-RKKQKEEERKR 359
GP +++ Q+E K E + +EA++R K EEE RKR EE +R +EE ++Q+EEERKR
Sbjct: 714 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 773
Query: 360 REKE---YEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS 416
RE+E +++ ++++REQ I+ + E+ QQ AL++ + E+
Sbjct: 774 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRRE---EEER 827
Query: 417 NDKGDIAKNLVDENSK--KQEDVLLWLVEESNMKENVDRQTILKESIQVKLKE-SISSQT 473
+ ++ + +E +K ++E+ +EE+ ++ + + E + K KE + Q
Sbjct: 828 RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQK 887
Query: 474 ILADFKMEEKN--ENLAKKRCSEELVKQERKYENT---DNKTELGNSDLKGNLKEQFPLQ 528
L + +++ L +++ ++L + + +T + T S +L E L+
Sbjct: 888 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLE 947
Query: 529 E-----LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKI 583
E L+ + +++++ + + + Q+ Q + G T + I+ + +++
Sbjct: 948 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1007
Query: 584 QKVEKEEIQEQ 594
QK ++++ Q Q
Sbjct: 1008 QKQQQQQQQHQ 1018
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 85.5 bits (210), Expect = 4e-16
Identities = 91/431 (21%), Positives = 196/431 (45%), Gaps = 52/431 (12%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDE 235
E+ ++LE + L+ +R E + + EEE E+K+ E +++Q+++ + +
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEE-----------ERKRQEELRRQQEEILRRQ 793
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
+E K +E+ + L Q E+E + ++E+E+ +QQ A +++ + +
Sbjct: 794 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEER----QQQEEALRRLEERRR 849
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEE 355
+K ++++Q E +A +W +E + +++ EENR R+EEE R + +EE
Sbjct: 850 EEEERRKQEELLRKQEE----EAAKWAREEEEAQRRLEENRLRMEEE----AARLRHEEE 901
Query: 356 ERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG----------- 404
ERKR+E E + +K +++Q ++Q + + L++ QQ + L S
Sbjct: 902 ERKRKELEVQRQKELMRQRQQQQEALRR--LQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 959
Query: 405 YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVK 464
+ LSL +I + + + L +E ++Q +++ L ++ ++ K S
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ-------KLSGWGN 1012
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNK--TELGNSDLKGNLK 522
+ + + L + + EE + +++ ++ + R NT + T +GNS + G++
Sbjct: 1013 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNS-VWGSIN 1071
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQII--LGHNQEISEVKTN---EEQKIIKD 577
P + SD N N G + +G ++ K N + + +
Sbjct: 1072 TG-PPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSN 1130
Query: 578 NQQKKIQKVEK 588
Q KK+++ EK
Sbjct: 1131 RQNKKVEEEEK 1141
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/311 (22%), Positives = 153/311 (49%), Gaps = 26/311 (8%)
Query: 304 GPIIKE--QIESKKRKAQEWKEKEAKIRQK-EEENRKRLEEEQRIKEE-RKKQKEEERKR 359
GP +++ Q+E K E + +EA++R K EEE RKR EE +R +EE ++Q+EEERKR
Sbjct: 741 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 800
Query: 360 REKE---YEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS 416
RE+E +++ ++++REQ I+ + E+ QQ AL++ + E+
Sbjct: 801 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRRE---EEER 854
Query: 417 NDKGDIAKNLVDENSK--KQEDVLLWLVEESNMKENVDRQTILKESIQVKLKE-SISSQT 473
+ ++ + +E +K ++E+ +EE+ ++ + + E + K KE + Q
Sbjct: 855 RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQK 914
Query: 474 ILADFKMEEKN--ENLAKKRCSEELVKQERKYENT---DNKTELGNSDLKGNLKEQFPLQ 528
L + +++ L +++ ++L + + +T + T S +L E L+
Sbjct: 915 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLE 974
Query: 529 E-----LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKI 583
E L+ + +++++ + + + Q+ Q + G T + I+ + +++
Sbjct: 975 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1034
Query: 584 QKVEKEEIQEQ 594
QK ++++ Q Q
Sbjct: 1035 QKQQQQQQQHQ 1045
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 85.5 bits (210), Expect = 4e-16
Identities = 91/431 (21%), Positives = 196/431 (45%), Gaps = 52/431 (12%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDE 235
E+ ++LE + L+ +R E + + EEE E+K+ E +++Q+++ + +
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEE-----------ERKRQEELRRQQEEILRRQ 772
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
+E K +E+ + L Q E+E + ++E+E+ +QQ A +++ + +
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEER----QQQEEALRRLEERRR 828
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEE 355
+K ++++Q E +A +W +E + +++ EENR R+EEE R + +EE
Sbjct: 829 EEEERRKQEELLRKQEE----EAAKWAREEEEAQRRLEENRLRMEEE----AARLRHEEE 880
Query: 356 ERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG----------- 404
ERKR+E E + +K +++Q ++Q + + L++ QQ + L S
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRR--LQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 405 YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVK 464
+ LSL +I + + + L +E ++Q +++ L ++ ++ K S
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ-------KLSGWGN 991
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNK--TELGNSDLKGNLK 522
+ + + L + + EE + +++ ++ + R NT + T +GNS + G++
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNS-VWGSIN 1050
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQII--LGHNQEISEVKTN---EEQKIIKD 577
P + SD N N G + +G ++ K N + + +
Sbjct: 1051 TG-PPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSN 1109
Query: 578 NQQKKIQKVEK 588
Q KK+++ EK
Sbjct: 1110 RQNKKVEEEEK 1120
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/311 (22%), Positives = 153/311 (49%), Gaps = 26/311 (8%)
Query: 304 GPIIKE--QIESKKRKAQEWKEKEAKIRQK-EEENRKRLEEEQRIKEE-RKKQKEEERKR 359
GP +++ Q+E K E + +EA++R K EEE RKR EE +R +EE ++Q+EEERKR
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779
Query: 360 REKE---YEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS 416
RE+E +++ ++++REQ I+ + E+ QQ AL++ + E+
Sbjct: 780 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRRE---EEER 833
Query: 417 NDKGDIAKNLVDENSK--KQEDVLLWLVEESNMKENVDRQTILKESIQVKLKE-SISSQT 473
+ ++ + +E +K ++E+ +EE+ ++ + + E + K KE + Q
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQK 893
Query: 474 ILADFKMEEKN--ENLAKKRCSEELVKQERKYENT---DNKTELGNSDLKGNLKEQFPLQ 528
L + +++ L +++ ++L + + +T + T S +L E L+
Sbjct: 894 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLE 953
Query: 529 E-----LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKI 583
E L+ + +++++ + + + Q+ Q + G T + I+ + +++
Sbjct: 954 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1013
Query: 584 QKVEKEEIQEQ 594
QK ++++ Q Q
Sbjct: 1014 QKQQQQQQQHQ 1024
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 85.5 bits (210), Expect = 4e-16
Identities = 91/431 (21%), Positives = 196/431 (45%), Gaps = 52/431 (12%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDE 235
E+ ++LE + L+ +R E + + EEE E+K+ E +++Q+++ + +
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEE-----------ERKRQEELRRQQEEILRRQ 772
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
+E K +E+ + L Q E+E + ++E+E+ +QQ A +++ + +
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEER----QQQEEALRRLEERRR 828
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEE 355
+K ++++Q E +A +W +E + +++ EENR R+EEE R + +EE
Sbjct: 829 EEEERRKQEELLRKQEE----EAAKWAREEEEAQRRLEENRLRMEEE----AARLRHEEE 880
Query: 356 ERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG----------- 404
ERKR+E E + +K +++Q ++Q + + L++ QQ + L S
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRR--LQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 405 YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVK 464
+ LSL +I + + + L +E ++Q +++ L ++ ++ K S
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ-------KLSGWGN 991
Query: 465 LKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNK--TELGNSDLKGNLK 522
+ + + L + + EE + +++ ++ + R NT + T +GNS + G++
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNS-VWGSIN 1050
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQII--LGHNQEISEVKTN---EEQKIIKD 577
P + SD N N G + +G ++ K N + + +
Sbjct: 1051 TG-PPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSN 1109
Query: 578 NQQKKIQKVEK 588
Q KK+++ EK
Sbjct: 1110 RQNKKVEEEEK 1120
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/311 (22%), Positives = 153/311 (49%), Gaps = 26/311 (8%)
Query: 304 GPIIKE--QIESKKRKAQEWKEKEAKIRQK-EEENRKRLEEEQRIKEE-RKKQKEEERKR 359
GP +++ Q+E K E + +EA++R K EEE RKR EE +R +EE ++Q+EEERKR
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779
Query: 360 REKE---YEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS 416
RE+E +++ ++++REQ I+ + E+ QQ AL++ + E+
Sbjct: 780 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRRE---EEER 833
Query: 417 NDKGDIAKNLVDENSK--KQEDVLLWLVEESNMKENVDRQTILKESIQVKLKE-SISSQT 473
+ ++ + +E +K ++E+ +EE+ ++ + + E + K KE + Q
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQK 893
Query: 474 ILADFKMEEKN--ENLAKKRCSEELVKQERKYENT---DNKTELGNSDLKGNLKEQFPLQ 528
L + +++ L +++ ++L + + +T + T S +L E L+
Sbjct: 894 ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLE 953
Query: 529 E-----LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKI 583
E L+ + +++++ + + + Q+ Q + G T + I+ + +++
Sbjct: 954 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1013
Query: 584 QKVEKEEIQEQ 594
QK ++++ Q Q
Sbjct: 1014 QKQQQQQQQHQ 1024
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 84.7 bits (208), Expect = 7e-16
Identities = 53/223 (23%), Positives = 125/223 (56%), Gaps = 12/223 (5%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRD--REEKQFQEEEEKRHCWMKQFKVEKK 219
E EE+ R+ E E++++++ +E+Q K + ++E+Q +E+EE+ + E++
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMR------EQEEQ 277
Query: 220 KLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL 279
L+ ++ EQ++ E ++ + +E+ ++ EE +R QM E+ ++Q K++ +
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ----EEQMGKQEEQM 333
Query: 280 LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRL 339
+Q+ + + +K + +++Q E +++ ++ +++E ++R++EE+ RK+
Sbjct: 334 WEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQE 393
Query: 340 EEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKE 382
E+ KE+ +QKE+ R++ E+ E+K+ + KQE KE
Sbjct: 394 EQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 73.2 bits (178), Expect = 2e-12
Identities = 89/451 (19%), Positives = 211/451 (46%), Gaps = 50/451 (11%)
Query: 104 EESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEV 163
EE E+ ++ E++ E +S+ + L D+ LP + + E
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKEL-----KRKLETDKIPLPQEGQVR----EQ 57
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLEN 223
E + R+ +E++ ++ ++E Q + + E++ Q E++ ++ +V +++ +
Sbjct: 58 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 117
Query: 224 IQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQ--QEKEKNSLLK 281
+++ Q + + +E++ + ++ E +R Q+ E+ + ++Q Q +E+ ++
Sbjct: 118 REQEGQVREQEGQVREQE---GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 174
Query: 282 QQNNAAVKIQAKYKAFVAY--QKYGPI------IKEQIESKKRKAQEWKEKEAKIRQKEE 333
+Q + + + + ++ G + + EQ E +++ ++ E+E ++R++EE
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234
Query: 334 ENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQ 393
+ ++ E+ Q+ +E+ +KQ+E+ RK+ E+ E+++ + +QE + L KE+ E +Q
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 394 LIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDR 453
+ + ++ + + +E ++QE+ + +E M E ++
Sbjct: 295 -------------EEQMREQEEQMREQEEQMREQEEQMREQEEQM--GKQEEQMWEQKEQ 339
Query: 454 QTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQE---RKYENTDNKT 510
KE + K +E + Q + +M+++ E + K+ E++ KQE RK E K
Sbjct: 340 MWEQKEQMW-KQEEQMGEQ----EEQMQKQEEQVRKQ--EEQMRKQEEQMRKQEEQMRKQ 392
Query: 511 ELGNSDLK---GNLKEQFPLQELKSDAQKEE 538
E + K G KEQ QE + QKE+
Sbjct: 393 EEQMGEQKEQMGEQKEQMREQEEQMGEQKEQ 423
Score = 57.4 bits (137), Expect = 1e-07
Identities = 73/427 (17%), Positives = 203/427 (47%), Gaps = 53/427 (12%)
Query: 221 LENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQ-QEKEKNSL 279
+ I +E + N EL +E ++ + + + + +I+ L ++E ++ + Q +E+
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 280 LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRL 339
+++Q + + + + ++ G + +++ + ++++ Q +E+E ++R++E + R
Sbjct: 61 VREQEGQVREQEGQVR-----EQEGQVREQEGQVREQEGQV-REQEGQVREQEGQVR--- 111
Query: 340 EEEQRIKEERKKQKEEERKRREKEYE--EKKNIVKQEREQLISKEKIILREDASQQLIIS 397
E+E +++E+ + +E+E + RE+E + E++ V+++ Q+ +E + ++ +
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 171
Query: 398 SALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTIL 457
++ G + +G + ++ + E +E M E ++
Sbjct: 172 QVREQEG---------QVREQEGQVR----EQEGQMGE-------QEGQMGEQEEQMGEQ 211
Query: 458 KESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDL 517
+E +Q K +E + Q + +M ++ E + ++ E++ KQE + + + + +
Sbjct: 212 EEQMQ-KQEEQMGEQ----EEQMRKQEEQMGEQE--EQVQKQEEQVQKQEEQMRKQEEQM 264
Query: 518 KGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKD 577
+ +EQ QE + QKE+ + E TG++ + + ++ +++ EEQ ++
Sbjct: 265 REQ-EEQMREQEEQMLKQKEQTEQE----EQTGEQEEQM---REQEEQMREQEEQMREQE 316
Query: 578 NQQKKIQK---VEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKE 634
Q ++ ++ ++E++ EQ +++ K+ + KQ E +E + +++E
Sbjct: 317 EQMREQEEQMGKQEEQMWEQKEQMWEQKEQM---WKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 635 IYSKSKE 641
K +E
Sbjct: 374 QMRKQEE 380
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 82.8 bits (203), Expect = 3e-15
Identities = 164/719 (22%), Positives = 306/719 (42%), Gaps = 133/719 (18%)
Query: 15 ELDKLSISSLEKEDIESDAKSETQSDDSDT-DSVELPES-VLHCINIIKNRSKAVEELIL 72
E+++L+ S L K ++E+ + ++T + T DSVE S +L + SK VE L
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 73 QDLEDTDILSCSYGAVSNNHMHLRTGLSTEYE---ESSEQLIKILSEIEKEEFMRSKTDC 129
+ +++ L +S + M + L E E+SE+ IKIL + E E ++ +
Sbjct: 513 EIVQEKQSLQNCQN-LSKDLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSL 570
Query: 130 ATPDFVP-EPSPHDLPMDEHVLPD---DADINFGYCEVEEK-CRQSFEAWQEKQKELEDK 184
+ E D+ + +L + + E E++ ++ E ++EK + E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 185 EKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQ--------KQEQDKMNDEL 236
E + +++ E Q + K C K+E + EN + K+ D +
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 237 YKEEKIWKEKFKQHEEYI---RNLH-----------LQMEEERTRFKDQQEKEKNSLLKQ 282
++ E + KE + EE + RN+ LQ+E + + +Q K+ LLK
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 283 QNNAAVKIQAKYKAF-VAYQKYGPIIK------EQIESK-----------KRKAQEWKEK 324
+++ Y+ + Q+ ++ +Q+ES+ ++ +E K
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 325 EAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYE------EKKNI-------- 370
++ Q E+EN K LE+E E+ KKQ E+E KR ++ E E+ N+
Sbjct: 807 SKRLEQLEKEN-KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 371 --------------------VKQEREQLIS------KEKIILREDASQQLIISSALKKSG 404
+++E ++L+ K + LRED ++S LK
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-----LVSEKLKTQQ 920
Query: 405 YNNKHLSLEDISNDKGDIAKN----LVDENSKKQEDVLLWLVE---ESNMKENVDRQTIL 457
NN LE ++++ I N L DE S +D L+E ES +K++++ +
Sbjct: 921 MNN---DLEKLTHELEKIGLNKERLLHDEQS--TDDSRYKLLESKLESTLKKSLEIKEEK 975
Query: 458 KESIQVKLKESIS-SQTILADFKMEEKNENLAKKRCSEE-LVKQERKYENTDNKTELGNS 515
+++ +L+ES + +Q + + K +KN K+R EE +V+ DNK E +
Sbjct: 976 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 516 D-LKGNLKEQFPLQE-------LKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 567
+ + LK + L E L+++ Q + +K + +N + QI+ Q +S
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS--- 1092
Query: 568 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRE 626
+EQ Q K+Q VE + Q+ L L+I + SL +EN ++E
Sbjct: 1093 -LQEQNTTLQTQNAKLQ-VENSTLNSQSTSLMNQNAQLLI----QQSSLENENESVIKE 1145
Score = 75.9 bits (185), Expect = 3e-13
Identities = 148/719 (20%), Positives = 291/719 (40%), Gaps = 142/719 (19%)
Query: 14 AELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELI-- 71
A DKL LEKE+++ AK + D D ++ E + + + + ++++E +
Sbjct: 372 ARSDKLH--ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 72 ---LQDLEDTDILS-CSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKT 127
L+ + T LS ++ + L + + E ++ L K + E+
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR--------- 480
Query: 128 DCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQ 187
T D V + L M++ + E+ ++ +QS + Q K+L ++ Q
Sbjct: 481 --TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-KQSLQNCQNLSKDLMKEKAQ 537
Query: 188 ---TLKAQRDREEKQFQ-EEEEKRH-----------------CWMKQFKVEKKKLENIQK 226
T++ R+ E+Q + E+E H +K + E K L K
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 227 QEQDKMND------ELYKEEKIWKEKFKQHEEYIRNL-HLQMEEER-----TRFKDQQEK 274
+ K++ ++ KE + +KEK ++ EE L HL+ E E T K EK
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 275 -----EKNSLLKQQNNAAVKIQAKYKAFV----AYQKYGPIIKEQIESKKRKAQEWKEKE 325
++NS L+++N K +K + +K + E+ +R + K
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 326 AKIRQKEEENRKRLEEEQRIKEE--------RKKQKEE--------ERKRREKEYEEKKN 369
K+ Q + EN++ E++++K+ +K ++ E E +R +K E
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 370 IVKQEREQL--ISKEKIILREDASQQLIISSALKKSGYNNKHLSLE--DISNDKGDIAKN 425
++Q +L + E L+++ + I S L++ NK L E + DK + K
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 426 LVDENSKKQEDVLLWLVEESNMK----------------------------ENVDRQTIL 457
++ ++Q ++ +EE+N+K E +++ +
Sbjct: 838 --NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 458 KESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELV--KQER----KYENTDNKTE 511
+ +I +K ++ + K ++ N +L K E + +ER + D++ +
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK 955
Query: 512 LGNSDLKGNLKEQFPLQELKSDAQKEEKI--MKHVINENTGQKTQIILGHNQEISEVKTN 569
L S L+ LK+ + KEEKI ++ + E+T Q+ QE+ VK N
Sbjct: 956 LLESKLESTLKKSLEI--------KEEKIAALEARLEESTNYNQQL----RQELKTVKKN 1003
Query: 570 EEQKIIKDNQQKKIQKVE---------KEEIQEQNGLLYKDKDTLVISVKQRSLSLTSE 619
E + ++++ +Q + E QE L K KD L I V++ + +L +E
Sbjct: 1004 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL-IEVERNNATLQAE 1061
Score = 72.8 bits (177), Expect = 3e-12
Identities = 134/670 (20%), Positives = 268/670 (40%), Gaps = 92/670 (13%)
Query: 99 LSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE-HVLPDDA--- 154
L E EE +EQL+ E+E+ E + + + + + DE L + A
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 155 ---------------DINFGYCEVEE-------------KCRQSFEAWQEKQKELEDKEK 186
DI F VEE E + + +L + EK
Sbjct: 323 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 187 QTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWK-- 244
+ L+ + + + + + +++ +++ E LE QKQ D+ ++ E+I +
Sbjct: 383 ENLQLKAKLHDMEMERDMDRKK--IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 245 ------EKFKQHE--EYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKA 296
+K HE E + L++E E E+ + ++ + NA+ KI K
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS-KILKMEKE 499
Query: 297 FVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK---QK 353
K I++ +I +K+ Q + + +++ + K +E + E + K Q+
Sbjct: 500 NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 354 EEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLE 413
E + ++ I + R + I KE IL E + SS L K + + + E
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE---TSSKLSKIEFEKRQIKKE 616
Query: 414 -DISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQ 472
+ +KG+ A+ L +E +++ L + +N+K ++ L++ +E+ +
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 473 TILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKS 532
L FK NL + S E + EN + + + + Q L+ +
Sbjct: 677 KTLDSFK------NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 533 DAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKE--E 590
+++KE+ + + + +KT+ + Q + +++ QK + +N KKIQ++E E +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGL-DIENQRLQKTL-ENSNKKIQQLESELQD 788
Query: 591 IQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQ--EKEIYSKSKEIEENPKD 648
++ +N L K+ + L IS K R L EN +E L+ +K++ ++K + + +
Sbjct: 789 LEMENQTLQKNLEELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE- 846
Query: 649 NAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEI 708
I +TT N++ + N E+ +SKE+ K
Sbjct: 847 --------IKDTTLEENNVK------------------IGNLEKENKTLSKEIGIYKESC 880
Query: 709 RNISEKCHEN 718
+ E EN
Sbjct: 881 VRLKELEKEN 890
Score = 64.3 bits (155), Expect = 1e-09
Identities = 114/530 (21%), Positives = 235/530 (44%), Gaps = 91/530 (17%)
Query: 172 EAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLE--------- 222
E+ Q EL D + + + +++ EEK Q + K+ ++Q ++E K+L+
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE--LEQMEIELKRLQQENMNLLSD 301
Query: 223 ----NIQKQEQDKMNDELYKEEKI------WKEK------FKQHEEYIRNLHLQMEEERT 266
+ + E D + ++ + +K+ +KE+ +K E ++ + + E +T
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 267 RFKDQQE--KEKNSLLKQQNNAAVKIQAK-----YKAFVAYQKYGPIIKEQIESKKRKAQ 319
+DQ E + ++ L + ++++AK + + +K +++E + + + Q
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 320 E--------WK-EKEAKIRQKEEENRKRL-EEEQRIKEERKKQKEEERKRREKEYEEKK- 368
W+ E+ ++ + E +K L E + R + E E + K EE +
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 369 ----------NIVKQERE-QLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISN 417
I+K E+E Q +SK+ IL + Q+ K+S N ++LS +D+
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-------KQSLQNCQNLS-KDLMK 533
Query: 418 DKGDIAKNL--VDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL 475
+K + K + + ENS++Q +L E+ N N QT+ ++ + IS++ +
Sbjct: 534 EKAQLEKTIETLRENSERQIKIL----EQENEHLN---QTV----SSLRQRSQISAEARV 582
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQ 535
D + E K + + K S +L K E +E K EL + KG E+ EL +
Sbjct: 583 KDIEKENKILHESIKETSSKLSKIE--FEKRQIKKELEHYKEKGERAEELE-NELHHLEK 639
Query: 536 KEEKIMKHVIN-ENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQ 594
+ E + K + N + T +K + + N E+ E +K+ K K + E ++++
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELE----RENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 595 NGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEE 644
N L D++ L + SL S ++ L+ KE+ S+ +++++
Sbjct: 696 NSQL--DEENLELRRNVESLKCASMKMAQLQ----LENKELESEKEQLKK 739
Score = 60.8 bits (146), Expect = 1e-08
Identities = 115/557 (20%), Positives = 235/557 (42%), Gaps = 52/557 (9%)
Query: 243 WKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQK 302
W E +E I L M R D++++ ++++ + + A
Sbjct: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
Query: 303 YGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREK 362
G ++ ES++ + E + +AKIR+ +E ++ E+ K+E +Q E E KR +
Sbjct: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQ- 292
Query: 363 EYEEKKNIVKQEREQLISKEKI-ILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGD 421
+E N++ R + ++++ LRE A + + S + S Y + L DI K
Sbjct: 293 --QENMNLLSDARSARMYRDELDALREKAVRVDKLESEV--SRYKER---LHDIEFYKAR 345
Query: 422 IAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKME 481
+ E K+ VL L ++ +++ ++ + + KE++ + L D +ME
Sbjct: 346 V------EELKEDNQVL--LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
Query: 482 EKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIM 541
+ ++ EEL+++ E ++ + L L++ EL QK +
Sbjct: 398 RDMD----RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS---L 450
Query: 542 KHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKD 601
H +NE T + + NQ ++ KT EE + D+ + K+ K ++++N L K
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLT--KTVEELRTTVDSVEGNASKILK--MEKENQRLSKK 506
Query: 602 KDTLVISVKQRSLSLTS--ENSKDVRENVILQEKEI----YSKSKEIEENPKDNAWNSGI 655
+ L + Q SL + SKD+ + EK I + ++I+ ++N +
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 656 VIFNTTDTMINIEGKRND---QDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNIS 712
V + I+ E + D ++ +L E + +++ S + E +K E+ +
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILH-----ESIKETSSKLSKIEFEKRQIKKELEHYK 621
Query: 713 EKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVK 772
EK + + E+ LL ++++ +K +E +Q + ++ R R +K
Sbjct: 622 EKGERAEELENELHHLEKENELL----QKKITNLKITCEKIEALEQ-ENSELERENRKLK 676
Query: 773 CP----ANMTPALDKLE 785
N+T L+ LE
Sbjct: 677 KTLDSFKNLTFQLESLE 693
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.8 bits (203), Expect = 3e-15
Identities = 136/607 (22%), Positives = 258/607 (42%), Gaps = 106/607 (17%)
Query: 21 ISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELILQDLEDTDI 80
+ L + + +++ ++ ++ +SD + V + + + ++ R K E L+ + E
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ- 303
Query: 81 LSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIE--KEEFMRSKTDCATPDFVPEP 138
+H T L++E E EQL + L E+E K+ M KT T +
Sbjct: 304 ----------SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
Query: 139 SPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEK 198
L D+ ++ + E RQ E + K++E+ + + EE
Sbjct: 354 LIEQLEQDKGMV------------IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEEL 401
Query: 199 QFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLH 258
+ Q+E+ +R F+ +K L QK E+ + R L
Sbjct: 402 REQKEKSER----AAFEELEKALSTAQKTEEAR-----------------------RKLK 434
Query: 259 LQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKA 318
+M+E+ + E+E+ SL QQ + VK Q+ ++K+ E + K
Sbjct: 435 AEMDEQIKTIEKTSEEERISL--QQELSRVK-----------QEVVDVMKKSSEEQIAKL 481
Query: 319 QEWKEKEAKIRQKEEENRKRLE-EEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQ 377
Q+ EKE + +KE+E K+L+ E+ +E+ K E+ + K +EK+ E+
Sbjct: 482 QKLHEKE--LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 378 LISKEKIILRE------DASQQ--------LIISSALKKSGYNNKHLSLEDISNDKGDIA 423
L ++K IL E D Q+ L + S+L+KS NK N D+A
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK--------NQSKDLA 591
Query: 424 KNLVDENSKKQEDVLLWLVEESNMKENVDRQ--TILKESIQVKLKESISSQTILADFKME 481
+L E +K +++ + + + E++ Q + E +QV LK+ ++ K E
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV-LKQQYQTEMEKLREKCE 650
Query: 482 EKNENLAKKRCSEELVKQ---ERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE 538
++ E L K +E++ Q E E T K ++ ++L+ E + LK+ + EE
Sbjct: 651 QEKETLLK---DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL--SEVLKARHKLEE 705
Query: 539 KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQ--KKIQKVEKEEIQEQNG 596
++ V+ + T + Q + E + IIK+++ ++ +K K++I Q
Sbjct: 706 EL--SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI-NQLE 762
Query: 597 LLYKDKD 603
LL K++D
Sbjct: 763 LLLKERD 769
Score = 82.8 bits (203), Expect = 3e-15
Identities = 151/748 (20%), Positives = 301/748 (40%), Gaps = 99/748 (13%)
Query: 1 MDDDDAKLKAEIEAELDKLS------ISSLEKEDIESDAKSETQSDDSDTD--------S 46
+ D K+K E+EA++D+ + S+ KE S ++E D
Sbjct: 710 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Query: 47 VELPESVLHCINIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEES 106
L E H N+ + ++ EL Q D+ SY + ++ + YEE
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGEL-QQASAKLDVFQ-SYQSATHEQ-------TKAYEEQ 820
Query: 107 SEQLIKILSEIEKEEFMRSK----TDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCE 162
QL + L ++E E + +K + D E H + + + + + E
Sbjct: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM----QQLEKQNSE 876
Query: 163 VEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLE 222
+E+K + + ++ K ++ +++QT KQ E+E M++ +KK++E
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQT---------KQILVEKENMILQMREG--QKKEIE 925
Query: 223 NIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQ 282
I Q+ D ++ + ++ KFK E+ + + + +E + K + ++ L K+
Sbjct: 926 -ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 283 QNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEE 342
N A+++ K K F A S E +KE +I E +R+ L +
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE-QIESLTEVHRRELNDV 1043
Query: 343 QRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKK 402
I E++ Q+ E E +E I QE+EQ +++ K Q I+ +K
Sbjct: 1044 ISIWEKKLNQQAE-------ELQEIHEIQLQEKEQEVAELK---------QKILLFGCEK 1087
Query: 403 SGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ 462
N + L++ + L ++ +K V +E+ +K ++++ L+ +
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK---LEVDLN 1144
Query: 463 VKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKG--- 519
LKE+ Q L + KM + + + +L + ++++ + E N L+
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 520 ---NLKEQFPLQELKSDAQKEEKIMKHVINE---NTGQKTQIILGHNQEISEVKTNEEQK 573
L E+ +Q L +K E +++ NE + KT IL T ++
Sbjct: 1205 EFKKLSEELAIQ-LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263
Query: 574 IIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENS--KDVRENV--I 629
++ I+ E++ Q L ++++TL IS +Q + L + + K ++ ++ +
Sbjct: 1264 LL-------IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
Query: 630 LQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSN 689
+ EKE K ++ + T + E N L + E L
Sbjct: 1317 VTEKEALQKEGGNQQQAASEK--------ESCITQLKKELSENINAVTLMK----EELKE 1364
Query: 690 YNAESSMVSKEVNSLKSEIRN---ISEK 714
E S +SK++ L +++N +SEK
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 73.2 bits (178), Expect = 2e-12
Identities = 126/653 (19%), Positives = 281/653 (43%), Gaps = 109/653 (16%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKK-- 219
E+ K ++ + Q +++E +++ K L+ + K QE+E++ +++ +++KK
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 220 ------KLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQE 273
KL ++Q QE + + + E ++ ++++ ++L + +E E K++
Sbjct: 548 LTESENKLRDLQ-QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE----KNKHN 602
Query: 274 KEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQE--WKEKEAKIRQK 331
KE ++++ + K++ + + ++K+Q +++ K +E +EKE ++ K
Sbjct: 603 KEITVMVEKHKTELESL--KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 332 --------EEENRKRLEE---------------------EQRIKEE---RKKQKEEERKR 359
EE N K LE+ +++EE K Q ++ ++
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
Query: 360 REKEYEEKKNIVKQEREQLISKEKI-ILREDASQQLIISSALKKSGYNNKHLSLED--IS 416
E + +E+KN +Q+ + +I + ++ I R + + + I+ +KHL +
Sbjct: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
Query: 417 NDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLK-ESISSQTIL 475
N + DI ++ E +Q L + + + + ++ Q++ K + ++ IL
Sbjct: 781 NLEADIKRS---EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL 837
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELK-SDA 534
++ E KK EL + + ++ + E NS+++ +K + E K D
Sbjct: 838 LTKQVAEVEAQ--KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895
Query: 535 QKEEKIMKHVINENTGQKTQIILGHNQEISEVKT-------------NEEQKIIKDNQQK 581
KE++ K ++ E Q+ G +EI E+ T NEE + NQ+K
Sbjct: 896 NKEQEQTKQILVEKENMILQMREGQKKEI-EILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 582 KIQKVEK--EEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVI-LQEKEIYSK 638
K++KV++ +E+QE ++K++ L ++ K++ + L +KE
Sbjct: 955 KMEKVKQKAKEMQE--------------TLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 639 SKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVS 698
+K +E ++A +D + +E + +Q L E N S+
Sbjct: 1001 AKMLEMAQANSA--------GISDAVSRLETNQKEQIESLTEVHRRE----LNDVISIWE 1048
Query: 699 KEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEE----RRLAWIK 747
K++N E++ I E E + + + LL+ E+ + + W+K
Sbjct: 1049 KKLNQQAEELQEIHE---IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Score = 72.4 bits (176), Expect = 4e-12
Identities = 100/489 (20%), Positives = 212/489 (43%), Gaps = 50/489 (10%)
Query: 162 EVEEKCRQSFE-------AWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQF 214
E+E + RQ E ++Q+ +LE+KE Q + D E ++E ++ +Q
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 215 KVEKKK--LENIQKQEQDKMND-ELYKEE-KIWKEKFKQHEEYIRNLHLQM--------- 261
+K+ + ++K+ + +N L KEE K K + + + +L++Q+
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 262 EEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEW 321
E + + Q ++EK LL Q + + K+ K ++ EQ++ K EW
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKIS-------ALEQVDDWSNKFSEW 1445
Query: 322 KEKEAKIRQKEEENRKRLEEEQRIKEERKKQKE-------EERKRREKEYEEKKNIVKQE 374
K+K + + K L+ + +K + +K+ EE ++ K ++ K ++ +
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 375 REQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQ 434
+ ++ KE + E SQ I + K + +E ++ ++ KN + +
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMEL--EDHITQKTIEIESLN----EVLKNYNQQKDIEH 1559
Query: 435 EDVLLWLVEESNMKENVDRQTILKESIQVKLKESI-SSQTILADFKMEEKNENLAKKRCS 493
++++ L + E D + E + L+ + S + L K E ++ NL+ K
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE 1619
Query: 494 EELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK-----HVINEN 548
EEL E + E +++ +L K K ++L S +++E+ K H+ N
Sbjct: 1620 EELKALEDRLE-SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
Query: 549 TGQKTQIILGH--NQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLV 606
T + + H +++ V++++ + +I K + ++E + G + K +
Sbjct: 1679 TKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE-K 1737
Query: 607 ISVKQRSLS 615
ISV QR+L+
Sbjct: 1738 ISVLQRNLT 1746
Score = 72.0 bits (175), Expect = 5e-12
Identities = 145/727 (19%), Positives = 303/727 (41%), Gaps = 100/727 (13%)
Query: 1 MDDDDAKLK---AEIEAELDKLSISSLEKED------IESDAKSET---QSDDSDTDSVE 48
M+DD +K++ + +E EL + +E ED IE ++ +E + D + E
Sbjct: 1502 MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 49 LPESVLHCINIIK---NRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEE 105
L + + H + + NR K EE IL + H+ + ++ EE
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
Query: 106 --SSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEV 163
+ E ++ S + E R S + +++ ++ ++ ++
Sbjct: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 164 EEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQF---QEEEEKRHCWMKQFK----- 215
+E+ R+ +EK K +E + +TL R + QEE + + C K ++
Sbjct: 1682 QERERE-VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
Query: 216 -----VEKKKL-ENIQKQEQDKMNDEL-----YKEEKIWKE--KFKQHEEYIRNLHLQME 262
EK+KL + + +++++ ++ Y+E I E + KQHE+ HLQ E
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 263 EERTRFKDQQEKEKNSLLKQQN----NAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKA 318
E ++ +K SL+ Q+ IQAK + ++E+ + +
Sbjct: 1801 LE-------EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
Query: 319 QEWKEKEA-KIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQ 377
Q+ KE ++ +RQKE R+E E+ + K Q ++ R K E + +++ +
Sbjct: 1854 QKIKELDSCLVRQKEVH---RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 378 LISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDV 437
+ + K++ +A +N+ L +K + K +V + Q+D+
Sbjct: 1911 HLVQPKLLSNMEAQ-------------HNDLEFKLAGAEREKQKLGKEIV----RLQKDL 1953
Query: 438 LLWLVEESN----MKENVDRQT---ILKESIQVKLKESISSQTILADFKMEEKNENLAKK 490
+ E +K+ D++ I +E ++LK + + + ++ +F N LA+K
Sbjct: 1954 RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF-----NTQLAQK 2008
Query: 491 RCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTG 550
E+ +E T NK + ++L + +E+ Q LK A+K++ + + T
Sbjct: 2009 EQELEMTIKE-----TINKAQEVEAELLESHQEETN-QLLKKIAEKDDDLKR------TA 2056
Query: 551 QKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVK 610
++ + IL +E K + Q +++ Q+K QK+E+EE + + + T ++ K
Sbjct: 2057 KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQT-QLAQK 2115
Query: 611 QRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGK 670
+S + ++ RE + E + K + + G N T +++ G+
Sbjct: 2116 TTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGG----NLYHTDVSLFGE 2171
Query: 671 RNDQDYV 677
+ +Y+
Sbjct: 2172 PTEFEYL 2178
Score = 69.7 bits (169), Expect = 2e-11
Identities = 122/590 (20%), Positives = 249/590 (42%), Gaps = 82/590 (13%)
Query: 174 WQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMN 233
+ E++ EL D + Q L + D K+ E+ W +F KKK ++ Q Q+ +
Sbjct: 1403 YDEEKCELLD-QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
Query: 234 DELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRF---KDQQEKEKNSLLKQQNNAAVKI 290
+ + E KE +++ E+ I L +++++ RF K + E +K+ + K+++N ++
Sbjct: 1462 ELQIQLELKSKEAYEKDEQ-INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 291 QAKYKAFVAYQKYGPIIKEQIES--------KKRKAQEWKEKEAKIRQ-----KEEENR- 336
+++ + + + +IES ++K E KE K++ +E++NR
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 337 KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLII 396
K EE+ E + + E + ++KE E VK + E+L + E + E A++ +
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 397 SSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTI 456
K + + I+ K + + ++ + ++ L E + + +R+
Sbjct: 1641 -----------KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVH 1689
Query: 457 LKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSD 516
+ E ++K ES S+T++ + +N+A EE Q + + K + +
Sbjct: 1690 ILEE-KLKSVESSQSETLI----VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 517 LK---------GNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 567
L G KE+ + Q +E+++K E + Q ++GH QE E K
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 568 TNEEQKII---------KDNQQKK---------IQKV--EKE---EIQEQNGLLYKDKDT 604
+ I+ K+N Q K +QK EKE +I EQ K+ D+
Sbjct: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK---IKELDS 1861
Query: 605 LVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTM 664
++ K+ E + + LQ+ + +K E+ E + S +V +
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV---QPKLL 1918
Query: 665 INIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEK 714
N+E + ND ++ L+ E + KE+ L+ ++R + ++
Sbjct: 1919 SNMEAQHNDLEF---------KLAGAEREKQKLGKEIVRLQKDLRMLRKE 1959
Score = 67.0 bits (162), Expect = 1e-10
Identities = 110/569 (19%), Positives = 245/569 (43%), Gaps = 100/569 (17%)
Query: 165 EKCRQSFEAWQEKQKELEDKEKQTLKA-QRDREEKQFQEEEEKRHCWMKQFKVEKK---- 219
EK + + +E +++L+ + + +K ++ EE++ ++E + V KK
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 220 ---KLENIQKQEQDKMNDELYKEEKIWKEKF---------KQHEEYIRNLHLQMEEERTR 267
KL+ + ++E + EL K+ + + +F K EY++ + + E++ +
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK-ISQEKEQQESL 535
Query: 268 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327
++ E +K ++L + N +Q + + Y I E S ++ QE K +
Sbjct: 536 ALEELELQKKAILTESENKLRDLQQE------AETYRTRILELESSLEKSLQENKNQSKD 589
Query: 328 IR-QKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQ----EREQLISK- 381
+ E E K +E + E+ K + E + +++ + EK ++KQ E E+L K
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 382 --EKIILREDASQQLIISSALKKSGYNN------KHLSLEDISNDKGDIAKN-------- 425
EK L +D +++I + +++ K LE +S++ ++ K
Sbjct: 650 EQEKETLLKD--KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEEL 707
Query: 426 --LVDENSKKQEDVLLWLVEESN-MKENVDRQTILKE---SIQVKLKESISSQTILADFK 479
L D+ K ++++ + E+ N ++ VD +I+KE SIQ + ++++ Q +
Sbjct: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVD--SIIKEHEVSIQ-RTEKALKDQINQLELL 764
Query: 480 MEEKNENLAK------------KRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPL 527
++E++++L + KR EL + K + + + K ++ L
Sbjct: 765 LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 528 QELKSDAQKEEKIMKHVINENTGQKTQI----------ILGHNQEISEVKTNEEQKIIKD 577
Q+ D + E ++ + E QK + + Q++ + + EQK+
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 578 NQ--QKKIQKVEKEEIQEQNGLLYKDKDTLV-----------------ISVKQRSLSLTS 618
Q + K++ KE QEQ + +K+ ++ +S K+ S+ + +
Sbjct: 885 TQVYESKLEDGNKE--QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942
Query: 619 ENSKDVRENVILQEKEIYSKSKEIEENPK 647
E + +N + +++ K+KE++E K
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLK 971
Score = 62.4 bits (150), Expect = 4e-09
Identities = 96/468 (20%), Positives = 197/468 (42%), Gaps = 57/468 (12%)
Query: 176 EKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL----ENIQKQEQDK 231
E Q +E+ TL + Q +E+E + +K K + + L E +QK+ ++
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQ----IKSMKADIESLVTEKEALQKEGGNQ 1330
Query: 232 MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQ 291
KE I + K K+ E I + L EE + +++ E +SL KQ + V++Q
Sbjct: 1331 QQAASEKESCITQLK-KELSENINAVTLMKEELK-----EKKVEISSLSKQLTDLNVQLQ 1384
Query: 292 AKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK 351
+ K+ E K + ++ K+ +E LE+ ++
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV----DDWSN 1440
Query: 352 QKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLS 411
+ E +K+ + + + +N VK+ + QL K K +D L+
Sbjct: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL------------ 1488
Query: 412 LEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISS 471
D N + D K ++++ K E +ESN++ + QT + ++L++ I+
Sbjct: 1489 --DQQNKRFDCLKGEMEDDKSKMEK------KESNLETELKSQT----ARIMELEDHITQ 1536
Query: 472 QTILADFKMEE-KNENLAKKRCSEELVKQERKY----ENTDNKTELGNSDLKGNLKEQFP 526
+TI + E KN N K +ELV++ + + E DN+ + + L +
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI---LTLENQ 1593
Query: 527 LQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQ-------EISEVKTNEEQKIIKDNQ 579
+ +K++ + ++K ++HV ++ ++ ++ +++E+K EQKI +
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653
Query: 580 QKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 627
Q Q EKEE ++ + + + ++R + + E K V +
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS 1701
Score = 60.8 bits (146), Expect = 1e-08
Identities = 96/520 (18%), Positives = 220/520 (42%), Gaps = 57/520 (10%)
Query: 217 EKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEK 276
EKKKL+ I Q QDK L + ++ +E LQM+++ K ++E
Sbjct: 170 EKKKLQGILSQSQDK---SLRRIAELREE-------------LQMDQQA---KKHLQEEF 210
Query: 277 NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENR 336
++ L++++ +Q + + GP+ ++ K Q + E +++ E+
Sbjct: 211 DASLEEKDQYISVLQTQVSLLKQRLRNGPM---NVDVLKPLPQLEPQAEVFTKEENPESD 267
Query: 337 KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQ--LISKEKIILREDASQQL 394
E + + ++ KR+E + K ++ +EQ L++ EK L+E ++L
Sbjct: 268 GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL 327
Query: 395 IISSALKKSGYNNKHLSLEDISNDKGDIA-----KNLVDENSKKQEDVLLWLVEE--SNM 447
+K K + + + K I K +V +K+Q L + EE + +
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 448 KENVDRQTILKESI--QVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYEN 505
+ + + T E + Q + E + + + +K E A+++ E+ +Q + E
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE-ARRKLKAEMDEQIKTIEK 446
Query: 506 TDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISE 565
T + + +K++ KS ++ K+ K ++E + + L + E
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK--LHEKELARKEQELTKKLQTRE 504
Query: 566 VKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENS-KDV 624
+ E+ K+ + Q + K+ +E+ Q+++ L + + ++++++ SEN +D+
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE------LELQKKAILTESENKLRDL 558
Query: 625 RENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIE---GKRNDQDYVLGRH 681
++ I +E++ ++N S D +++E K N + V+
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQS-------KDLAVHLEAEKNKHNKEITVMVEK 611
Query: 682 APCEGLSNYNAESSMVSKEVNSLK----SEIRNISEKCHE 717
E S + + ++ ++++ LK +E+ + EKC +
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Score = 56.2 bits (134), Expect = 3e-07
Identities = 134/661 (20%), Positives = 269/661 (40%), Gaps = 135/661 (20%)
Query: 8 LKAEIEA---ELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRS 64
+KAE+E EL+ +++S KE+ E A + +S EL + +
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEE-ELKALEDRLESESAAKLAELKRKA-------EQKI 1648
Query: 65 KAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMR 124
A+++ +L +E+ + Y + +H+ + L+T+ +E ++ + +++ E +
Sbjct: 1649 AAIKKQLLSQMEEKEE---QYKKGTESHL---SELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 125 SKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSF--EAWQEK----Q 178
S+T ++P A Y E EE Q + ++EK Q
Sbjct: 1703 SET--------------------LIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ 1742
Query: 179 KELEDKEKQTLKAQRDREEK---------QFQEEEEK-RHCWMKQFKVEKKKLENIQKQE 228
+ L +KEK + +++EE Q+QE K H KQ + ++ + ++Q++
Sbjct: 1743 RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE-DQSMIGHLQEEL 1801
Query: 229 QDKMND-ELYKEEKIWKEKFKQHEEYIRNLH---------LQMEEERTRFKDQQEKEKNS 278
++K L + + KE K + + +NL LQ +E + +Q+ KE +S
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 279 LLKQQNNA----AVKIQAKYKAFVAYQ------KYGPIIKEQIESKKRK----------- 317
L +Q ++ +KY+ A Q K +++E E K +
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNM 1921
Query: 318 -------------AQEWKEKEAK--------IRQKEEENRKRLE--EEQRIKEERKKQKE 354
A+ K+K K +R +E+++ LE +++ +E +K K+
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ 1981
Query: 355 EERKRREKEYEEKKNIVKQEREQLISKE---KIILREDASQQLIISSALKKSGYNNKHLS 411
E+ K K ++++ QL KE ++ ++E ++ + + L +S +
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041
Query: 412 LEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKE---SIQVKLKES 468
L+ I+ D+ + +K+ E++L EE K D QT L+E Q KL++
Sbjct: 2042 LKKIAEKDDDLKR-----TAKRYEEILDAREEEMTAKVR-DLQTQLEELQKKYQQKLEQE 2095
Query: 469 ----------ISSQTILADFKMEEKNENLAKKRCSEELVKQE---RKYENTDNKTELGNS 515
+ QT LA + L ++ E++ E +KYE T +G
Sbjct: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTP 2155
Query: 516 DLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKII 575
GNL L + + E + K + G++T+ + + + ++ QKI+
Sbjct: 2156 YKGGNLYHTD--VSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFPDDQTQKIL 2213
Query: 576 K 576
+
Sbjct: 2214 E 2214
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 82.4 bits (202), Expect = 3e-15
Identities = 123/602 (20%), Positives = 258/602 (42%), Gaps = 97/602 (16%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
QE++ + ++ E Q K ++ + E + +E E+K Q EK L QEQ +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKH----SQLTEEKNLL-----QEQLQAET 900
Query: 235 ELYKEEKIWK----EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKI 290
ELY E + + K ++ EE + + ++EEE R Q + E+ + +Q + ++
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQL 959
Query: 291 QAKYKAFVAYQKYGPIIKEQIESKKRKAQ-EWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
E+ E+ ++K Q E EAKI++ E+E ++ ++ +ER
Sbjct: 960 ------------------EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 350 KKQKE---EERKRREKEYEEKKNI--VKQEREQLISKEKIIL-REDASQQLIISSALKKS 403
K +E + +E E+ KN+ +K + E +IS+ ++ L +E+ S+Q + K
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 404 G-YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ 462
G ++ H + D+ ++ L +KK+E++ L +D + K +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQL----AKKEEELQAALA-------RLDDEIAQKNNAL 1110
Query: 463 VKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLK 522
K++E + + + E+L +R + K E++ + + E ++L+ L
Sbjct: 1111 KKIRE--------LEGHISDLQEDLDSERAARN--KAEKQKRDLGEELEALKTELEDTLD 1160
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKK 582
QEL++ ++E ++K ++E T H ++ E++ Q + + +Q +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 583 IQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEI 642
K K + + L +K+ ++ + R L + + ++ + Q +E+ SK +
Sbjct: 1214 QFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 643 EENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVN 702
E + + +N+ + V G EG ++ ++K+V
Sbjct: 1272 ER--------------ARAELNDKVHKLQNEVESVTGMLNEAEG------KAIKLAKDVA 1311
Query: 703 SLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQK 762
SL S++++ E E + ++ ST L +EE R + +E KQN ++
Sbjct: 1312 SLSSQLQDTQELLQEETRQK------LNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLER 1364
Query: 763 KI 764
I
Sbjct: 1365 HI 1366
Score = 72.8 bits (177), Expect = 3e-12
Identities = 128/730 (17%), Positives = 293/730 (40%), Gaps = 75/730 (10%)
Query: 9 KAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVE--LPESVLHCINIIKNRSKA 66
K ++EA++ +L + E ++ + ++ +SV L E+ I + K+ +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 67 VEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSK 126
+L QD ++ + + +ST+ + E+ + ++++E +
Sbjct: 1314 SSQL--QDTQE----------LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 127 TDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEK 186
+ + S + + +A + G +++ + ++EK + EK
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 187 QTLKAQRDREE--------KQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYK 238
+ Q++ ++ +Q EK+ Q E+K + + E+D+ E +
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 239 EEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFV 298
+E + EE L+ +EE R + E L+ +++ + K+
Sbjct: 1481 KETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 299 AYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERK 358
A + +K Q+E + + Q ++ + ++ + + + E + + ++E+ ++K + +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 359 RREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISND 418
R+ EYE + +++R + +K + + +L SA+K G L +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK--GREEAIKQLRKLQAQ 1653
Query: 419 KGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL--- 475
D + L D + + E + KEN + L+ + ++L+E +++
Sbjct: 1654 MKDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADL-MQLQEDLAAAERARKQ 1705
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSD-- 533
AD + EE E LA ++ E++ + E + L+ L+E+ E SD
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKR------RLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 534 ---AQKEEKIMKHVINE-NTGQKT----QIILGHNQEISEVKTNEEQKIIKDNQQKKIQK 585
Q+ E++ + E +T QK Q + N+E+ K +E + +K + I
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSKFKSTIAA 1818
Query: 586 VEKE--EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIE 643
+E + +++EQ ++K S+KQ+ L + ++LQ ++ +++
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---------KEILLQVED----ERKMA 1865
Query: 644 ENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNS 703
E K+ A + + E + Q R L + + +EVN+
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQL--EEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 704 LKSEIRNISE 713
LKS++R +E
Sbjct: 1924 LKSKLRRGNE 1933
Score = 72.0 bits (175), Expect = 5e-12
Identities = 128/714 (17%), Positives = 284/714 (39%), Gaps = 93/714 (13%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E++A+ D+L + ++ E++ K Q T+ L + L + ++ +
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 71 ILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCA 130
+ ++ + + A L E ++ ++Q++ + ++E+EE R K
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 131 TPD------------FVPEPSPHDLPMDEHVLPDD-ADINFGYCEVEEKCRQSFEAWQEK 177
V + + L + +L + +D+ E EEK + + +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 178 QKELEDKEKQTLKAQRDREEKQ------------FQEEEEKRHCWMKQFKVEKKKLENIQ 225
+ + + E + K ++ R+E + F E+ + + K++ K E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 226 KQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL------ 279
+ +++DE+ ++ K K ++ E +I +L ++ ER +++ EK+K L
Sbjct: 1093 QAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAA-RNKAEKQKRDLGEELEA 1150
Query: 280 LKQQ-----NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
LK + ++ A + + + K + E+ S + + QE ++K A Q EE
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA---QAVEE 1207
Query: 335 NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQL 394
++LE+ +R K K K+ K E + + + ++E K+K+ + Q
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 395 IISSALKKSGYNNKHLSLED------------------ISNDKGDIAKNLVDENSKKQED 436
++ N+K L++ ++ D ++ L D QE+
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 437 V---------LLWLVEESN-MKENVDRQTILKESIQVKLK----ESISSQTILADFKMEE 482
L L EE N +++ +D + K++++ + + S+ L DF
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 483 KNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK 542
+ KKR +E+ ++YE K + K + Q L +L D + +++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 543 HVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE-----------KEEI 591
++ E +K +L + IS +E + + ++K+ + + KEE+
Sbjct: 1445 NL--EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 592 QEQNGLLYKDKDTLVISVKQRSLSLTS-ENSKDVRENVILQEKEIYSKSKEIEE 644
+ N +L + + LV S ++ E SK E Q +E+ ++ +E+E+
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEELED 1553
Score = 66.6 bits (161), Expect = 2e-10
Identities = 90/414 (21%), Positives = 185/414 (44%), Gaps = 42/414 (10%)
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
R F +Q++ + Q+N AA ++ + + K P+++ + ++ +A+E + +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 325 EAKIRQKEEENR-KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNI------VKQEREQ 377
+ K RQ++ EN K LE++ E K +E+ + + Y E + + KQE E+
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 378 LISKEKIILREDASQQLIISSALKKSGYN----NKHLSLEDISNDKGDIAKNLVDENSKK 433
++ + + L E+ + + + KK + L E+ + K + K + KK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 434 QEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTI-LADFKMEEKNENLAKKRC 492
ED +L ++++ N K + +R+ L+E IS T LA+ EEK +NL K +
Sbjct: 983 LEDEIL-VMDDQNNKLSKERKL---------LEERISDLTTNLAE--EEEKAKNLTKLKN 1030
Query: 493 SEELVKQE-----RKYENTDNKTELGNSDLKGNLKE--------QFPLQELKSD-AQKEE 538
E + E +K E + + E L+G+ + Q + ELK A+KEE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 539 KIMKHV--INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNG 596
++ + +++ QK + + + +E + + K +K +++ +E
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 597 LLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNA 650
L + +DTL + Q+ L E V + + ++E S +++E + +A
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKAL--DEETRSHEAQVQEMRQKHA 1202
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 82.4 bits (202), Expect = 3e-15
Identities = 123/602 (20%), Positives = 258/602 (42%), Gaps = 97/602 (16%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
QE++ + ++ E Q K ++ + E + +E E+K Q EK L QEQ +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKH----SQLTEEKNLL-----QEQLQAET 907
Query: 235 ELYKEEKIWK----EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKI 290
ELY E + + K ++ EE + + ++EEE R Q + E+ + +Q + ++
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQL 966
Query: 291 QAKYKAFVAYQKYGPIIKEQIESKKRKAQ-EWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
E+ E+ ++K Q E EAKI++ E+E ++ ++ +ER
Sbjct: 967 ------------------EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 350 KKQKE---EERKRREKEYEEKKNI--VKQEREQLISKEKIIL-REDASQQLIISSALKKS 403
K +E + +E E+ KN+ +K + E +IS+ ++ L +E+ S+Q + K
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 404 G-YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ 462
G ++ H + D+ ++ L +KK+E++ L +D + K +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQL----AKKEEELQAALA-------RLDDEIAQKNNAL 1117
Query: 463 VKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLK 522
K++E + + + E+L +R + K E++ + + E ++L+ L
Sbjct: 1118 KKIRE--------LEGHISDLQEDLDSERAARN--KAEKQKRDLGEELEALKTELEDTLD 1167
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKK 582
QEL++ ++E ++K ++E T H ++ E++ Q + + +Q +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 583 IQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEI 642
K K + + L +K+ ++ + R L + + ++ + Q +E+ SK +
Sbjct: 1221 QFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 643 EENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVN 702
E + + +N+ + V G EG ++ ++K+V
Sbjct: 1279 ER--------------ARAELNDKVHKLQNEVESVTGMLNEAEG------KAIKLAKDVA 1318
Query: 703 SLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQK 762
SL S++++ E E + ++ ST L +EE R + +E KQN ++
Sbjct: 1319 SLSSQLQDTQELLQEETRQK------LNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLER 1371
Query: 763 KI 764
I
Sbjct: 1372 HI 1373
Score = 72.8 bits (177), Expect = 3e-12
Identities = 128/730 (17%), Positives = 293/730 (40%), Gaps = 75/730 (10%)
Query: 9 KAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVE--LPESVLHCINIIKNRSKA 66
K ++EA++ +L + E ++ + ++ +SV L E+ I + K+ +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 67 VEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSK 126
+L QD ++ + + +ST+ + E+ + ++++E +
Sbjct: 1321 SSQL--QDTQE----------LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 127 TDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEK 186
+ + S + + +A + G +++ + ++EK + EK
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 187 QTLKAQRDREE--------KQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYK 238
+ Q++ ++ +Q EK+ Q E+K + + E+D+ E +
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 239 EEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFV 298
+E + EE L+ +EE R + E L+ +++ + K+
Sbjct: 1488 KETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 299 AYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERK 358
A + +K Q+E + + Q ++ + ++ + + + E + + ++E+ ++K + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 359 RREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISND 418
R+ EYE + +++R + +K + + +L SA+K G L +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK--GREEAIKQLRKLQAQ 1660
Query: 419 KGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL--- 475
D + L D + + E + KEN + L+ + ++L+E +++
Sbjct: 1661 MKDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADL-MQLQEDLAAAERARKQ 1712
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSD-- 533
AD + EE E LA ++ E++ + E + L+ L+E+ E SD
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKR------RLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 534 ---AQKEEKIMKHVINE-NTGQKT----QIILGHNQEISEVKTNEEQKIIKDNQQKKIQK 585
Q+ E++ + E +T QK Q + N+E+ K +E + +K + I
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSKFKSTIAA 1825
Query: 586 VEKE--EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIE 643
+E + +++EQ ++K S+KQ+ L + ++LQ ++ +++
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---------KEILLQVED----ERKMA 1872
Query: 644 ENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNS 703
E K+ A + + E + Q R L + + +EVN+
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQL--EEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 704 LKSEIRNISE 713
LKS++R +E
Sbjct: 1931 LKSKLRRGNE 1940
Score = 72.0 bits (175), Expect = 5e-12
Identities = 128/714 (17%), Positives = 284/714 (39%), Gaps = 93/714 (13%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E++A+ D+L + ++ E++ K Q T+ L + L + ++ +
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 71 ILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCA 130
+ ++ + + A L E ++ ++Q++ + ++E+EE R K
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 131 TPD------------FVPEPSPHDLPMDEHVLPDD-ADINFGYCEVEEKCRQSFEAWQEK 177
V + + L + +L + +D+ E EEK + + +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 178 QKELEDKEKQTLKAQRDREEKQ------------FQEEEEKRHCWMKQFKVEKKKLENIQ 225
+ + + E + K ++ R+E + F E+ + + K++ K E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 226 KQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL------ 279
+ +++DE+ ++ K K ++ E +I +L ++ ER +++ EK+K L
Sbjct: 1100 QAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAA-RNKAEKQKRDLGEELEA 1157
Query: 280 LKQQ-----NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
LK + ++ A + + + K + E+ S + + QE ++K A Q EE
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA---QAVEE 1214
Query: 335 NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQL 394
++LE+ +R K K K+ K E + + + ++E K+K+ + Q
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 395 IISSALKKSGYNNKHLSLED------------------ISNDKGDIAKNLVDENSKKQED 436
++ N+K L++ ++ D ++ L D QE+
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 437 V---------LLWLVEESN-MKENVDRQTILKESIQVKLK----ESISSQTILADFKMEE 482
L L EE N +++ +D + K++++ + + S+ L DF
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 483 KNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK 542
+ KKR +E+ ++YE K + K + Q L +L D + +++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 543 HVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE-----------KEEI 591
++ E +K +L + IS +E + + ++K+ + + KEE+
Sbjct: 1452 NL--EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 592 QEQNGLLYKDKDTLVISVKQRSLSLTS-ENSKDVRENVILQEKEIYSKSKEIEE 644
+ N +L + + LV S ++ E SK E Q +E+ ++ +E+E+
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEELED 1560
Score = 66.6 bits (161), Expect = 2e-10
Identities = 90/414 (21%), Positives = 185/414 (44%), Gaps = 42/414 (10%)
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
R F +Q++ + Q+N AA ++ + + K P+++ + ++ +A+E + +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 325 EAKIRQKEEENR-KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNI------VKQEREQ 377
+ K RQ++ EN K LE++ E K +E+ + + Y E + + KQE E+
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 378 LISKEKIILREDASQQLIISSALKKSGYN----NKHLSLEDISNDKGDIAKNLVDENSKK 433
++ + + L E+ + + + KK + L E+ + K + K + KK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 434 QEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTI-LADFKMEEKNENLAKKRC 492
ED +L ++++ N K + +R+ L+E IS T LA+ EEK +NL K +
Sbjct: 990 LEDEIL-VMDDQNNKLSKERKL---------LEERISDLTTNLAE--EEEKAKNLTKLKN 1037
Query: 493 SEELVKQE-----RKYENTDNKTELGNSDLKGNLKE--------QFPLQELKSD-AQKEE 538
E + E +K E + + E L+G+ + Q + ELK A+KEE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 539 KIMKHV--INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNG 596
++ + +++ QK + + + +E + + K +K +++ +E
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 597 LLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNA 650
L + +DTL + Q+ L E V + + ++E S +++E + +A
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKAL--DEETRSHEAQVQEMRQKHA 1209
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 82.4 bits (202), Expect = 3e-15
Identities = 123/602 (20%), Positives = 258/602 (42%), Gaps = 97/602 (16%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
QE++ + ++ E Q K ++ + E + +E E+K Q EK L QEQ +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKH----SQLTEEKNLL-----QEQLQAET 907
Query: 235 ELYKEEKIWK----EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKI 290
ELY E + + K ++ EE + + ++EEE R Q + E+ + +Q + ++
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQL 966
Query: 291 QAKYKAFVAYQKYGPIIKEQIESKKRKAQ-EWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
E+ E+ ++K Q E EAKI++ E+E ++ ++ +ER
Sbjct: 967 ------------------EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 350 KKQKE---EERKRREKEYEEKKNI--VKQEREQLISKEKIIL-REDASQQLIISSALKKS 403
K +E + +E E+ KN+ +K + E +IS+ ++ L +E+ S+Q + K
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 404 G-YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ 462
G ++ H + D+ ++ L +KK+E++ L +D + K +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQL----AKKEEELQAALA-------RLDDEIAQKNNAL 1117
Query: 463 VKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLK 522
K++E + + + E+L +R + K E++ + + E ++L+ L
Sbjct: 1118 KKIRE--------LEGHISDLQEDLDSERAARN--KAEKQKRDLGEELEALKTELEDTLD 1167
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKK 582
QEL++ ++E ++K ++E T H ++ E++ Q + + +Q +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 583 IQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEI 642
K K + + L +K+ ++ + R L + + ++ + Q +E+ SK +
Sbjct: 1221 QFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 643 EENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVN 702
E + + +N+ + V G EG ++ ++K+V
Sbjct: 1279 ER--------------ARAELNDKVHKLQNEVESVTGMLNEAEG------KAIKLAKDVA 1318
Query: 703 SLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQK 762
SL S++++ E E + ++ ST L +EE R + +E KQN ++
Sbjct: 1319 SLSSQLQDTQELLQEETRQK------LNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLER 1371
Query: 763 KI 764
I
Sbjct: 1372 HI 1373
Score = 72.0 bits (175), Expect = 5e-12
Identities = 128/714 (17%), Positives = 284/714 (39%), Gaps = 93/714 (13%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E++A+ D+L + ++ E++ K Q T+ L + L + ++ +
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 71 ILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCA 130
+ ++ + + A L E ++ ++Q++ + ++E+EE R K
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 131 TPD------------FVPEPSPHDLPMDEHVLPDD-ADINFGYCEVEEKCRQSFEAWQEK 177
V + + L + +L + +D+ E EEK + + +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 178 QKELEDKEKQTLKAQRDREEKQ------------FQEEEEKRHCWMKQFKVEKKKLENIQ 225
+ + + E + K ++ R+E + F E+ + + K++ K E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 226 KQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL------ 279
+ +++DE+ ++ K K ++ E +I +L ++ ER +++ EK+K L
Sbjct: 1100 QAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAA-RNKAEKQKRDLGEELEA 1157
Query: 280 LKQQ-----NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
LK + ++ A + + + K + E+ S + + QE ++K A Q EE
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA---QAVEE 1214
Query: 335 NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQL 394
++LE+ +R K K K+ K E + + + ++E K+K+ + Q
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 395 IISSALKKSGYNNKHLSLED------------------ISNDKGDIAKNLVDENSKKQED 436
++ N+K L++ ++ D ++ L D QE+
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 437 V---------LLWLVEESN-MKENVDRQTILKESIQVKLK----ESISSQTILADFKMEE 482
L L EE N +++ +D + K++++ + + S+ L DF
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 483 KNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK 542
+ KKR +E+ ++YE K + K + Q L +L D + +++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 543 HVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE-----------KEEI 591
++ E +K +L + IS +E + + ++K+ + + KEE+
Sbjct: 1452 NL--EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 592 QEQNGLLYKDKDTLVISVKQRSLSLTS-ENSKDVRENVILQEKEIYSKSKEIEE 644
+ N +L + + LV S ++ E SK E Q +E+ ++ +E+E+
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEELED 1560
Score = 72.0 bits (175), Expect = 5e-12
Identities = 127/726 (17%), Positives = 291/726 (40%), Gaps = 75/726 (10%)
Query: 9 KAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVE--LPESVLHCINIIKNRSKA 66
K ++EA++ +L + E ++ + ++ +SV L E+ I + K+ +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 67 VEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSK 126
+L QD ++ + + +ST+ + E+ + ++++E +
Sbjct: 1321 SSQL--QDTQE----------LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 127 TDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEK 186
+ + S + + +A + G +++ + ++EK + EK
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 187 QTLKAQRDREE--------KQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYK 238
+ Q++ ++ +Q EK+ Q E+K + + E+D+ E +
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 239 EEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFV 298
+E + EE L+ +EE R + E L+ +++ + K+
Sbjct: 1488 KETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 299 AYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERK 358
A + +K Q+E + + Q ++ + ++ + + + E + + ++E+ ++K + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 359 RREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISND 418
R+ EYE + +++R + +K + + +L SA+K G L +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK--GREEAIKQLRKLQAQ 1660
Query: 419 KGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL--- 475
D + L D + + E + KEN + L+ + ++L+E +++
Sbjct: 1661 MKDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADL-MQLQEDLAAAERARKQ 1712
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSD-- 533
AD + EE E LA ++ E++ + E + L+ L+E+ E SD
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKR------RLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 534 ---AQKEEKIMKHVINE-NTGQKT----QIILGHNQEISEVKTNEEQKIIKDNQQKKIQK 585
Q+ E++ + E +T QK Q + N+E+ K +E + +K + I
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSKFKSTIAA 1825
Query: 586 VEKE--EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIE 643
+E + +++EQ ++K S+KQ+ L + ++LQ ++ +++
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---------KEILLQVED----ERKMA 1872
Query: 644 ENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNS 703
E K+ A + + E + Q R L + + +EVN+
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQL--EEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 704 LKSEIR 709
LKS++R
Sbjct: 1931 LKSKLR 1936
Score = 66.6 bits (161), Expect = 2e-10
Identities = 90/414 (21%), Positives = 185/414 (44%), Gaps = 42/414 (10%)
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
R F +Q++ + Q+N AA ++ + + K P+++ + ++ +A+E + +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 325 EAKIRQKEEENR-KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNI------VKQEREQ 377
+ K RQ++ EN K LE++ E K +E+ + + Y E + + KQE E+
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 378 LISKEKIILREDASQQLIISSALKKSGYN----NKHLSLEDISNDKGDIAKNLVDENSKK 433
++ + + L E+ + + + KK + L E+ + K + K + KK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 434 QEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTI-LADFKMEEKNENLAKKRC 492
ED +L ++++ N K + +R+ L+E IS T LA+ EEK +NL K +
Sbjct: 990 LEDEIL-VMDDQNNKLSKERKL---------LEERISDLTTNLAE--EEEKAKNLTKLKN 1037
Query: 493 SEELVKQE-----RKYENTDNKTELGNSDLKGNLKE--------QFPLQELKSD-AQKEE 538
E + E +K E + + E L+G+ + Q + ELK A+KEE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 539 KIMKHV--INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNG 596
++ + +++ QK + + + +E + + K +K +++ +E
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 597 LLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNA 650
L + +DTL + Q+ L E V + + ++E S +++E + +A
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKAL--DEETRSHEAQVQEMRQKHA 1209
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 82.4 bits (202), Expect = 3e-15
Identities = 123/602 (20%), Positives = 258/602 (42%), Gaps = 97/602 (16%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
QE++ + ++ E Q K ++ + E + +E E+K Q EK L QEQ +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKH----SQLTEEKNLL-----QEQLQAET 900
Query: 235 ELYKEEKIWK----EKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKI 290
ELY E + + K ++ EE + + ++EEE R Q + E+ + +Q + ++
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQL 959
Query: 291 QAKYKAFVAYQKYGPIIKEQIESKKRKAQ-EWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
E+ E+ ++K Q E EAKI++ E+E ++ ++ +ER
Sbjct: 960 ------------------EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 350 KKQKE---EERKRREKEYEEKKNI--VKQEREQLISKEKIIL-REDASQQLIISSALKKS 403
K +E + +E E+ KN+ +K + E +IS+ ++ L +E+ S+Q + K
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 404 G-YNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQ 462
G ++ H + D+ ++ L +KK+E++ L +D + K +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQL----AKKEEELQAALA-------RLDDEIAQKNNAL 1110
Query: 463 VKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLK 522
K++E + + + E+L +R + K E++ + + E ++L+ L
Sbjct: 1111 KKIRE--------LEGHISDLQEDLDSERAARN--KAEKQKRDLGEELEALKTELEDTLD 1160
Query: 523 EQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKK 582
QEL++ ++E ++K ++E T H ++ E++ Q + + +Q +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 583 IQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEI 642
K K + + L +K+ ++ + R L + + ++ + Q +E+ SK +
Sbjct: 1214 QFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 643 EENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVN 702
E + + +N+ + V G EG ++ ++K+V
Sbjct: 1272 ER--------------ARAELNDKVHKLQNEVESVTGMLNEAEG------KAIKLAKDVA 1311
Query: 703 SLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQK 762
SL S++++ E E + ++ ST L +EE R + +E KQN ++
Sbjct: 1312 SLSSQLQDTQELLQEETRQK------LNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLER 1364
Query: 763 KI 764
I
Sbjct: 1365 HI 1366
Score = 72.0 bits (175), Expect = 5e-12
Identities = 128/714 (17%), Positives = 284/714 (39%), Gaps = 93/714 (13%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E++A+ D+L + ++ E++ K Q T+ L + L + ++ +
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 71 ILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCA 130
+ ++ + + A L E ++ ++Q++ + ++E+EE R K
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 131 TPD------------FVPEPSPHDLPMDEHVLPDD-ADINFGYCEVEEKCRQSFEAWQEK 177
V + + L + +L + +D+ E EEK + + +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 178 QKELEDKEKQTLKAQRDREEKQ------------FQEEEEKRHCWMKQFKVEKKKLENIQ 225
+ + + E + K ++ R+E + F E+ + + K++ K E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 226 KQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL------ 279
+ +++DE+ ++ K K ++ E +I +L ++ ER +++ EK+K L
Sbjct: 1093 QAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAA-RNKAEKQKRDLGEELEA 1150
Query: 280 LKQQ-----NNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
LK + ++ A + + + K + E+ S + + QE ++K A Q EE
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA---QAVEE 1207
Query: 335 NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQL 394
++LE+ +R K K K+ K E + + + ++E K+K+ + Q
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 395 IISSALKKSGYNNKHLSLED------------------ISNDKGDIAKNLVDENSKKQED 436
++ N+K L++ ++ D ++ L D QE+
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 437 V---------LLWLVEESN-MKENVDRQTILKESIQVKLK----ESISSQTILADFKMEE 482
L L EE N +++ +D + K++++ + + S+ L DF
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 483 KNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMK 542
+ KKR +E+ ++YE K + K + Q L +L D + +++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 543 HVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVE-----------KEEI 591
++ E +K +L + IS +E + + ++K+ + + KEE+
Sbjct: 1445 NL--EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 592 QEQNGLLYKDKDTLVISVKQRSLSLTS-ENSKDVRENVILQEKEIYSKSKEIEE 644
+ N +L + + LV S ++ E SK E Q +E+ ++ +E+E+
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEELED 1553
Score = 72.0 bits (175), Expect = 5e-12
Identities = 127/726 (17%), Positives = 291/726 (40%), Gaps = 75/726 (10%)
Query: 9 KAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVE--LPESVLHCINIIKNRSKA 66
K ++EA++ +L + E ++ + ++ +SV L E+ I + K+ +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 67 VEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSK 126
+L QD ++ + + +ST+ + E+ + ++++E +
Sbjct: 1314 SSQL--QDTQE----------LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 127 TDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEK 186
+ + S + + +A + G +++ + ++EK + EK
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 187 QTLKAQRDREE--------KQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYK 238
+ Q++ ++ +Q EK+ Q E+K + + E+D+ E +
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 239 EEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFV 298
+E + EE L+ +EE R + E L+ +++ + K+
Sbjct: 1481 KETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 299 AYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERK 358
A + +K Q+E + + Q ++ + ++ + + + E + + ++E+ ++K + +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 359 RREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISND 418
R+ EYE + +++R + +K + + +L SA+K G L +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK--GREEAIKQLRKLQAQ 1653
Query: 419 KGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTIL--- 475
D + L D + + E + KEN + L+ + ++L+E +++
Sbjct: 1654 MKDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADL-MQLQEDLAAAERARKQ 1705
Query: 476 ADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSD-- 533
AD + EE E LA ++ E++ + E + L+ L+E+ E SD
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKR------RLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 534 ---AQKEEKIMKHVINE-NTGQKT----QIILGHNQEISEVKTNEEQKIIKDNQQKKIQK 585
Q+ E++ + E +T QK Q + N+E+ K +E + +K + I
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSKFKSTIAA 1818
Query: 586 VEKE--EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIE 643
+E + +++EQ ++K S+KQ+ L + ++LQ ++ +++
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---------KEILLQVED----ERKMA 1865
Query: 644 ENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNS 703
E K+ A + + E + Q R L + + +EVN+
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQL--EEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 704 LKSEIR 709
LKS++R
Sbjct: 1924 LKSKLR 1929
Score = 66.6 bits (161), Expect = 2e-10
Identities = 90/414 (21%), Positives = 185/414 (44%), Gaps = 42/414 (10%)
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
R F +Q++ + Q+N AA ++ + + K P+++ + ++ +A+E + +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 325 EAKIRQKEEENR-KRLEEEQRIKEERKKQKEEERKRREKEYEEKKNI------VKQEREQ 377
+ K RQ++ EN K LE++ E K +E+ + + Y E + + KQE E+
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 378 LISKEKIILREDASQQLIISSALKKSGYN----NKHLSLEDISNDKGDIAKNLVDENSKK 433
++ + + L E+ + + + KK + L E+ + K + K + KK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 434 QEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTI-LADFKMEEKNENLAKKRC 492
ED +L ++++ N K + +R+ L+E IS T LA+ EEK +NL K +
Sbjct: 983 LEDEIL-VMDDQNNKLSKERKL---------LEERISDLTTNLAE--EEEKAKNLTKLKN 1030
Query: 493 SEELVKQE-----RKYENTDNKTELGNSDLKGNLKE--------QFPLQELKSD-AQKEE 538
E + E +K E + + E L+G+ + Q + ELK A+KEE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 539 KIMKHV--INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNG 596
++ + +++ QK + + + +E + + K +K +++ +E
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 597 LLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNA 650
L + +DTL + Q+ L E V + + ++E S +++E + +A
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKAL--DEETRSHEAQVQEMRQKHA 1202
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 82.0 bits (201), Expect = 4e-15
Identities = 128/679 (18%), Positives = 288/679 (42%), Gaps = 71/679 (10%)
Query: 11 EIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEEL 70
E+E+++ +L +ED+ES+ S +++ D E E++ + + + A +EL
Sbjct: 1108 ELESQISEL------QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 71 ILQDLEDTDILSCSYGAVSNNH----MHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSK 126
+ ++ +IL + + H +R S EE +EQL E+ R K
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL---------EQTKRVK 1212
Query: 127 TDCATPDFVPEPSPHDLPMDEHV-LPDDADINFGYCEVEEKCRQ---SFEAWQEKQKELE 182
+ E +L + V L D +VE + ++ F + + EL
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 183 DKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKI 242
DK + L+ + D + + K K F + +L++ Q+ Q++ +L K+
Sbjct: 1273 DKVTK-LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 243 ---------WKEKFKQHEE-------YIRNLHLQMEEERTRFKDQ------QEKEKNSLL 280
++E+ ++ EE I LH Q+ + + + +D E+ K L
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 281 KQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLE 340
K + + + K A+ +K ++++++ ++ + +K+++ + L
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 341 EEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSAL 400
EE+ I + EER R E E EK+ + +S + + E+A +Q L
Sbjct: 1452 EEKTI----SAKYAEERDRAEAEAREKET-------KALSLARAL--EEAMEQKAELERL 1498
Query: 401 KKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDR-QTILKE 459
K +ED+ + K D+ K++ +K + L VEE MK ++ + L+
Sbjct: 1499 NK----QFRTEMEDLMSSKDDVGKSV--HELEKSKRALEQQVEE--MKTQLEELEDELQA 1550
Query: 460 SIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYE-NTDNKTELGNSDLK 518
+ KL+ ++ Q + A F+ + + + + ++LV+Q R+ E +++ + + +
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVA 1610
Query: 519 GNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDN 578
K + L++L++ K I + + Q + +E+ + + + E+ + +
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ-MKDCMRELDDTRASREEILAQAK 1669
Query: 579 Q-QKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYS 637
+ +KK++ +E E IQ Q L ++ ++ L+ NS + +++ + +
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 638 KSKEIEENPKDNAWNSGIV 656
+ ++EE ++ N+ ++
Sbjct: 1730 RIAQLEEELEEEQGNTELI 1748
Score = 81.3 bits (199), Expect = 8e-15
Identities = 162/800 (20%), Positives = 332/800 (41%), Gaps = 119/800 (14%)
Query: 8 LKAEIEAELDKLSISS--LEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSK 65
LK E+E LD + K + E + +T +++ T ++ E + + S+
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE-------MRQKHSQ 1196
Query: 66 AVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYE-------ESSEQLIKILSEIE 118
AVEEL Q LE T + + + R L+ E + +S + K+ ++++
Sbjct: 1197 AVEELAEQ-LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 119 KEEFMRSKTDCATPDFVPEPSPHDLPMDEHV-LPDDAD-----INFGYCEVEEKCRQSFE 172
+ + ++ + + + + + +D L +D + + +E + + + E
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 173 AWQEKQKE---LEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQ 229
QE+ ++ L K KQ ++ +++ +Q +EEEE +H KQ ++ +++K+ +
Sbjct: 1316 LLQEENRQKLSLSTKLKQ-VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374
Query: 230 DKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSL---------- 279
D + EE K K ++ E + H EE+ D+ EK K L
Sbjct: 1375 DSVGCLETAEEV--KRKLQKDLEGLSQRH----EEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 280 LKQQNNAAVKIQAKYKAF---VAYQKYGPIIKEQIESKKRKAQEWKEKEAK----IRQKE 332
L Q +A ++ K K F +A +K I + E + R E +EKE K R E
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEK--TISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 333 EENRKRLEEEQRIKEERKKQKE-----EERKRREKEYEEKKNIVKQEREQLIS-----KE 382
E ++ E E+ K+ R + ++ ++ + E E+ K ++Q+ E++ + ++
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 383 KIILREDASQQLIISSALKKSGYNNKHLSLEDISNDK--------GDIAKNLVDENSKKQ 434
++ EDA +L ++ K+ + ++ S +K ++ L DE ++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 435 EDVLLWLVEESNMKE--------NVDRQTILKE--SIQVKLKESI--------SSQTILA 476
V E ++K+ N +R +K+ +Q ++K+ + S + ILA
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
Query: 477 DFK--------MEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNL------K 522
K ME + L ++ + E K++ + E + E+ NS KG L +
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726
Query: 523 EQFPLQELKSDAQKEE---KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQ 579
+ + +L+ + ++E+ +++ + + Q QI N E S + NE + + Q
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786
Query: 580 QKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKS 639
K++ KV+ +E++ YK T + K L +N R+ Q + K
Sbjct: 1787 NKEL-KVKLQEMEGTVKSKYKASIT-ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 640 KEI----------EENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSN 689
K++ E KD A + + + E + Q R L +
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL--EEAEEEAQRANASRRKLQRELED 1902
Query: 690 YNAESSMVSKEVNSLKSEIR 709
+ +++EV+SLK+++R
Sbjct: 1903 ATETADAMNREVSSLKNKLR 1922
Score = 70.9 bits (172), Expect = 1e-11
Identities = 88/486 (18%), Positives = 223/486 (45%), Gaps = 65/486 (13%)
Query: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKL-ENIQKQEQDKMN 233
+E + L K+++ + D E + +EEE +H + EKKK+ +NIQ+ E
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQH-----LQAEKKKMQQNIQELE----- 949
Query: 234 DELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAK 293
E +EE+ ++K LQ+E+ T K ++ +E+ +L+ QN K +
Sbjct: 950 -EQLEEEESARQK------------LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 294 YKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQK 353
+ +A + + + +E + AK++ K E LEE R +E+++++
Sbjct: 997 LEDRIA----------EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL 1046
Query: 354 EEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHL-SL 412
E+ R++ E + + + + + + Q+ + + +++ Q ++ +++ N L +
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106
Query: 413 EDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQ 472
++ + ++ ++L E + + + K ++ + E+++ +L++++ S
Sbjct: 1107 RELESQISELQEDLESERASRN--------KAEKQKRDLGEEL---EALKTELEDTLDST 1155
Query: 473 TILADFKMEEKNE-NLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELK 531
+ + + + E N+ KK EE E + + K +L L++ + +K
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ---TKRVK 1212
Query: 532 SDAQKEEKIMKHVINENTGQKTQIILG-----HNQEISEVKTNEEQKIIKDNQQKKIQ-- 584
++ +K ++ +++ E + ++ G H ++ E + E Q +K N+ ++++
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ--VKFNEGERVRTE 1270
Query: 585 ---KVEKEEIQEQN--GLL-YKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSK 638
KV K +++ N GLL D + ++ +L ++++++ + Q+ + +K
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 639 SKEIEE 644
K++E+
Sbjct: 1331 LKQVED 1336
Score = 69.3 bits (168), Expect = 3e-11
Identities = 86/408 (21%), Positives = 181/408 (44%), Gaps = 42/408 (10%)
Query: 265 RTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEK 324
R F +Q++ + Q+N AA ++ + + K P+++ + ++ A+E +
Sbjct: 796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELV 855
Query: 325 EAKIRQKEEENR----KRLEEE---QRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQ 377
+ + +Q ENR + L+ + ++++ + + Q E E +E + KQE E+
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 378 LISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDV 437
+ + + E+ + + + KK N + L + L +E S +Q+
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE------------EQLEEEESARQKLQ 963
Query: 438 LLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADF-----KMEEKNENLAKKRC 492
L + E+ +K+ + Q IL++ KE + +A+F + EEK+++LAK +
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 493 SEELV------------KQERKYENTDNKTELGNSDLKGNLKE-QFPLQELKSD-AQKEE 538
E + KQ ++ E T K E ++DL + E Q + ELK A+KEE
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 539 KIMKHV--INENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNG 596
++ + + E QK + + S++ +E + + K +K +++ +E
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143
Query: 597 LLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEE 644
L + +DTL + Q+ L E ++ + + E+E + +I+E
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTL--EEEAKTHEAQIQE 1189
Score = 68.2 bits (165), Expect = 7e-11
Identities = 126/609 (20%), Positives = 264/609 (43%), Gaps = 78/609 (12%)
Query: 236 LYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYK 295
L+ + K + +Q EE + EEE + +++Q +N L + + + + K +
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAK-----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ 884
Query: 296 AFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRK-------RLEEE----QR 344
++EQ++++ E +E A++ K++E + R+EEE Q
Sbjct: 885 -----------LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 345 IKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSG 404
++ E+KK ++ ++ E+ EE+ K + E++ ++ K L++ +Q+I+ K
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK--LKKLEEEQIILEDQNCKLA 991
Query: 405 YNNKHLS---LEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILK--- 458
K L E +N + K+ K + + ++ +EE +E RQ + K
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 459 --ESIQVKLKESISS-QTILADFKME--EKNENL--AKKRCSEELVKQE---RKYENTDN 508
E L + I+ Q +A+ KM+ +K E L A R EE ++ +K ++
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 509 KTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVIN---ENTGQKTQIILGHNQEISE 565
+ DL+ + ++ K D +E + +K + ++T + ++ QE++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 566 VKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVR 625
+K E++ + +IQ++ ++ Q L + + T + T EN +
Sbjct: 1172 LKKTLEEE--AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL 1229
Query: 626 EN---VILQEK-EIYSKSKEIEENPKD--NAWNSGIVIFNTTDTMINIEGKRNDQDYVLG 679
N V+LQ K + K K++E ++ +N G + T+ + + + D V G
Sbjct: 1230 ANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV--RTELADKVTKLQVELDNVTG 1287
Query: 680 RHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIE 739
LS +++SS ++K+ ++L+S++++ E E + +S ST L +E
Sbjct: 1288 L------LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK------LSLSTKLKQVE 1335
Query: 740 ERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVT 799
+ + SF+ LE + ++ K K+ A + K+E G +T ++V
Sbjct: 1336 DEK----NSFREQLE---EEEEAKHNLEKQIATLHAQVADMKKKMED-SVGCLETAEEVK 1387
Query: 800 TVTFQDLPG 808
+DL G
Sbjct: 1388 RKLQKDLEG 1396
Score = 65.9 bits (159), Expect = 3e-10
Identities = 116/551 (21%), Positives = 240/551 (43%), Gaps = 72/551 (13%)
Query: 160 YCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREE---KQFQEEE---EKRHCWMKQ 213
+ + E+K Q E+Q E E+ +Q L+ ++ E K+ +EE+ E ++C + +
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992
Query: 214 FKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQE 273
EKK LE+ + + +E K + + K K K HE I +L ++ E K +QE
Sbjct: 993 ---EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNK-HEAMITDLEERLRREE---KQRQE 1045
Query: 274 KEKNSLLKQQNNAAVKIQ-AKYKAFVAYQKYG------------PIIKEQIESKKRKAQE 320
EK + ++ + Q A+ +A +A K ++E+ K ++
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 321 WKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKE---EERKRREKEYEE------KKNIV 371
+E E++I + +E+ LE E+ + + +KQK EE + + E E+ + +
Sbjct: 1106 IRELESQISELQED----LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 372 KQEREQLISKEKIILREDA-SQQLIISSALKKSGYNNKHLS--LEDISNDKGDIAK---N 425
+ +REQ ++ K L E+A + + I +K + L+ LE K ++ K
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 426 LVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILAD-------- 477
L +E + +V + L + + + + + +QVK E +T LAD
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 478 --------FKMEEKNENLAKK--------RCSEELVKQERKYENTDNKTELGNSDLKGNL 521
+ + K+ L K + ++EL+++E + + + + D K +
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 522 KEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQK 581
+EQ +E +++ H + +K + +G + EVK + QK ++ Q+
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK-RKLQKDLEGLSQR 1400
Query: 582 KIQKVEK-EEIQEQNGLLYKDKDTLVISV-KQRSLSLTSENSKDVRENVILQEKEIYSKS 639
+KV +++++ L ++ D L++ + QR + E + + ++ +EK I +K
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 640 KEIEENPKDNA 650
E + + A
Sbjct: 1461 AEERDRAEAEA 1471
Score = 63.2 bits (152), Expect = 2e-09
Identities = 104/508 (20%), Positives = 228/508 (44%), Gaps = 41/508 (8%)
Query: 162 EVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQ-EEEEKRHCWMKQFKV---- 216
E+EE C +E+++ + + + K Q++ +E + Q EEEE ++ KV
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971
Query: 217 EKKKLENIQKQEQDKMNDELYKEEKIWKEK-------FKQHEEYIRNLHLQMEEERTRFK 269
+ KKLE Q +D+ N +L KE+K+ +++ + EE ++L +
Sbjct: 972 KLKKLEEEQIILEDQ-NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 270 DQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIR 329
D +E+ + ++Q + + + + + + + E K + A++ +E +A +
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 330 QKEEENRKRLEEEQRIKE------ERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEK 383
+ EEE ++ ++I+E E ++ E ER R K ++K+++ +E E L ++ +
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL-GEELEALKTELE 1149
Query: 384 IILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVE 443
L A+QQ + S ++ N +LE+ + + + ++S+ E++ L +
Sbjct: 1150 DTLDSTAAQQELRSK--REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 444 ESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKY 503
+K N+++ K++++ + E + +L K + +++ +K+ +L + + K+
Sbjct: 1208 TKRVKANLEK---AKQTLENERGELANEVKVLLQGKGDSEHK---RKKVEAQLQELQVKF 1261
Query: 504 ENTDN-KTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHV-INENTGQKTQIILGHNQ 561
+ +TEL + K ++ L K K+ K E+ Q TQ +L Q
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL---Q 1318
Query: 562 EISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTS--- 618
E + K + K+ + +K + + EE +E L K TL V +
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 619 --ENSKDVRENVILQEKEIYSKSKEIEE 644
E +++V+ + +K++ S+ EE
Sbjct: 1379 CLETAEEVKRKL---QKDLEGLSQRHEE 1403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,568,890
Number of Sequences: 37866
Number of extensions: 3146150
Number of successful extensions: 63377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 780
Number of HSP's successfully gapped in prelim test: 1439
Number of HSP's that attempted gapping in prelim test: 16027
Number of HSP's gapped (non-prelim): 16845
length of query: 1722
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1606
effective length of database: 13,855,062
effective search space: 22251229572
effective search space used: 22251229572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.