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Search of human proteins with 24431975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24431975 hypothetical protein LOC26148 [Homo sapiens]
(1247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24431975 hypothetical protein LOC26148 [Homo sapiens] 2507 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 67 1e-10
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 62 3e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 57 1e-07
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 56 2e-07
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 55 3e-07
gi|122937227 U2-associated SR140 protein [Homo sapiens] 55 5e-07
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 54 9e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 52 5e-06
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 52 5e-06
gi|104526627 triadin [Homo sapiens] 51 8e-06
gi|157738619 smoothelin-like 1 [Homo sapiens] 50 1e-05
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 50 1e-05
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 50 1e-05
gi|239745501 PREDICTED: similar to acyl-CoA synthetase medium-ch... 50 2e-05
gi|209529739 hypothetical protein LOC100132247 [Homo sapiens] 49 3e-05
gi|157074225 nuclear pore complex interacting protein-like 3 [Ho... 49 3e-05
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 49 3e-05
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 49 3e-05
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 48 5e-05
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 48 5e-05
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 48 5e-05
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 47 1e-04
gi|16445033 ACRC protein [Homo sapiens] 47 1e-04
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 47 1e-04
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 47 1e-04
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 47 1e-04
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 47 1e-04
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 47 1e-04
gi|169166609 PREDICTED: similar to ribonucleic acid binding prot... 46 2e-04
>gi|24431975 hypothetical protein LOC26148 [Homo sapiens]
Length = 1247
Score = 2507 bits (6498), Expect = 0.0
Identities = 1247/1247 (100%), Positives = 1247/1247 (100%)
Query: 1 MQSSALVESLITVKMAAENSEEGNTCIIPQRNLFKALSEEAWNSGFMGNSSRTADKENTL 60
MQSSALVESLITVKMAAENSEEGNTCIIPQRNLFKALSEEAWNSGFMGNSSRTADKENTL
Sbjct: 1 MQSSALVESLITVKMAAENSEEGNTCIIPQRNLFKALSEEAWNSGFMGNSSRTADKENTL 60
Query: 61 QCPKTPLRQDLEANEQDARPKQENHLHSLGRNKVGYHLHPSDKGQFDHSKDGWLGPGPMP 120
QCPKTPLRQDLEANEQDARPKQENHLHSLGRNKVGYHLHPSDKGQFDHSKDGWLGPGPMP
Sbjct: 61 QCPKTPLRQDLEANEQDARPKQENHLHSLGRNKVGYHLHPSDKGQFDHSKDGWLGPGPMP 120
Query: 121 AVHKAANGHSRTKMISTSIKTARKSKRASGLRINDYDNQCDVVYISQPITECHFENQKSI 180
AVHKAANGHSRTKMISTSIKTARKSKRASGLRINDYDNQCDVVYISQPITECHFENQKSI
Sbjct: 121 AVHKAANGHSRTKMISTSIKTARKSKRASGLRINDYDNQCDVVYISQPITECHFENQKSI 180
Query: 181 LSSRKTARKSTRGYFFNGDCCELPTVRTLARNLHSQEKASCSALASEAVFTPKQTLTIPA 240
LSSRKTARKSTRGYFFNGDCCELPTVRTLARNLHSQEKASCSALASEAVFTPKQTLTIPA
Sbjct: 181 LSSRKTARKSTRGYFFNGDCCELPTVRTLARNLHSQEKASCSALASEAVFTPKQTLTIPA 240
Query: 241 PRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEE 300
PRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEE
Sbjct: 241 PRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEE 300
Query: 301 TTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHL 360
TTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHL
Sbjct: 301 TTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHL 360
Query: 361 LPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSIS 420
LPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSIS
Sbjct: 361 LPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSIS 420
Query: 421 AEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYD 480
AEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYD
Sbjct: 421 AEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYD 480
Query: 481 TSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKN 540
TSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKN
Sbjct: 481 TSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKN 540
Query: 541 PSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQ 600
PSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQ
Sbjct: 541 PSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQ 600
Query: 601 TLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKR 660
TLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKR
Sbjct: 601 TLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKR 660
Query: 661 DPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSV 720
DPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSV
Sbjct: 661 DPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSV 720
Query: 721 PRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDT 780
PRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDT
Sbjct: 721 PRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDT 780
Query: 781 VVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWK 840
VVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWK
Sbjct: 781 VVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWK 840
Query: 841 SKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDV 900
SKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDV
Sbjct: 841 SKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDV 900
Query: 901 PPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEP 960
PPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEP
Sbjct: 901 PPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEP 960
Query: 961 EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNE 1020
EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNE
Sbjct: 961 EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNE 1020
Query: 1021 KMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEIL 1080
KMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEIL
Sbjct: 1021 KMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEIL 1080
Query: 1081 PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKT 1140
PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKT
Sbjct: 1081 PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKT 1140
Query: 1141 SLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKA 1200
SLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKA
Sbjct: 1141 SLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKA 1200
Query: 1201 TNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLDAK 1247
TNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLDAK
Sbjct: 1201 TNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLDAK 1247
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 67.0 bits (162), Expect = 1e-10
Identities = 124/521 (23%), Positives = 200/521 (38%), Gaps = 59/521 (11%)
Query: 750 EKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQELIANFNAQYM 809
E+E A+ K A E+ P E + + V E+ K E +E A A+
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASP--EKEAKSPVKEEAKSPAEAKSPEKEE--AKSPAEVK 545
Query: 810 KVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFK 869
+K ++E + P A++ + + K K +S + + SP + K
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605
Query: 870 LSNVCKWFLETTETRSLVIVKKLNTRLPGDVPP---VKHPLQKYAPSSLYPSSLQAERLK 926
S V + E +S V K + P +V K P ++ A S S + E K
Sbjct: 606 -SPVKEEAKSPAEAKSPV---KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 927 KHLK-KFPGATPAKNNWKMQKLWAKFRENPDQVE-PEDGSDVSPGPNSEDSIEEVKEDRN 984
K K P AK+ K + ++P++ + P SP E + VKE+
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP----EKAKSPVKEEAK 717
Query: 985 SHPPANLPTPASTRILRKY-SNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINP 1043
S A P + K S ++ + ++ ++ EK + D + E+K K +P
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 1044 LMSPKLALQVDADGFPVKPKST---EGMKGRKGKQV---------SEILPKAEVQSKRKR 1091
AD FP K KS E K K EI K EV+S K
Sbjct: 778 -----------ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKE 826
Query: 1092 TEGSSPPDSKNKGPTVKASKEKHADGATKTPA---AKRPAARDRSSQPPKKTSLKENKVK 1148
E P + K K P KA +EK A KT +K+ A + + PK KE V+
Sbjct: 827 EE--KPQEVKVKEPPKKAEEEK-APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 1149 IPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATN--RKQS 1206
PK+S ++ ++E E+ K P T K A K + ++P++ T +K+
Sbjct: 884 KPKESKVEA---KKEEAEDKKKVP-------TPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 1207 SGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLDAK 1247
PS + AA K+ K + ++ + +AK
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974
Score = 64.7 bits (156), Expect = 5e-10
Identities = 129/653 (19%), Positives = 232/653 (35%), Gaps = 112/653 (17%)
Query: 568 ETLEDTEKPSVNERPSEKDA--EQEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPIT 625
E E+ EK + E E++ E+E EGG ++E K E + P
Sbjct: 469 EVTEEEEKEAKEEEGKEEEGGEEEEAEGG------------EEETKSPPAE--EAASPEK 514
Query: 626 TAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVD 685
A P+ E +++ A P+E + PE+AK P + EEA + +
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEV----KSPEKAKS-----PAK--EEAKSPPE 563
Query: 686 NENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDAS 745
++ ++++ +S A S + S + + A++P P++ S
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV--------------- 608
Query: 746 KVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQELIANFN 805
K ++ A +P+ + +E P + + E+ K E E +E +
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSP---EKAKSPTKEEAKSPEKAKSPEKEEAKSP-- 663
Query: 806 AQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRS-RKCRSSLESQKCSPVQMLF 864
EK P +K K K++ +S K +S ++ + SP
Sbjct: 664 -------------EKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE---- 706
Query: 865 MTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDVPPVKHPLQKYAPSSLYPSSLQAER 924
K + K ++ E + ++ T K P+++ A S S E+
Sbjct: 707 ----KAKSPVKEEAKSPEKAKSPVKEEAKTP-----EKAKSPVKEEAKSPEKAKS--PEK 755
Query: 925 LKKHLKKFPGA-TPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDR 983
K K P A TPAK E +D P EEVK
Sbjct: 756 AKTLDVKSPEAKTPAKE------------------EARSPADKFPEKAKSPVKEEVKSPE 797
Query: 984 NSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINP 1043
+ P A + + K ++ ++ +++ + + E P E P+
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA-------- 849
Query: 1044 LMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPK-AEVQSKRKRTEGSSPPDSKN 1102
+PK + D+ K K + K+ + PK ++V++K++ E +
Sbjct: 850 --TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 1103 KGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSR 1162
K K ++ A KT AK+ ++ +P K KE + K+ P
Sbjct: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967
Query: 1163 KEKENTNKRPSQSIASETLTKPAKQKGAGESSS------RPQKATNRKQSSGK 1209
K K + S+ +KP +K SS+ P+KAT K + GK
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 49.3 bits (116), Expect = 2e-05
Identities = 94/461 (20%), Positives = 159/461 (34%), Gaps = 56/461 (12%)
Query: 246 DVQLPREDNPEEPSKEITS--HEEGGGDVSPRKEPQEPEVCPTKIK-PNLSSSPRSEETT 302
+ + P + P KE S EE + +E P ++K P + SP EE
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559
Query: 303 ASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLP 362
+ P A PE++ + + V +P + + E + P E+ P
Sbjct: 560 S-----PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 363 STESFSGGVSEDVISRPHSPPEIVSRE--ESPQCSENQSSPMGLEPPMSLGKAED--NQS 418
E+ S V SP E+ S E +SP E +S P K+ +
Sbjct: 615 PAEAKS-----PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 419 ISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDT 478
+ AE +S + + V K E + E A K E +
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK------------ 717
Query: 479 YDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVP 538
S E+ K+ K PE + ++ + A S + L++
Sbjct: 718 ------SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-------KSPEKAKTLDV--- 761
Query: 539 KNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIIT 598
K+P AK KE +P P+ + E+ + P + P ++DA+ + I
Sbjct: 762 KSPEAKTPAKE---EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK--EIPK 816
Query: 599 RQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIAC 658
++ +K+ + +E K E+ P + P + K D K P + A
Sbjct: 817 KEEVKSPVKEEEKP--QEVKVKEPPKKAEEEKAPATP---KTEEKKDSKKEEAPKKE-AP 870
Query: 659 KRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAP 699
K E+ KE P + EA E + + E +AP
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911
Score = 42.0 bits (97), Expect = 0.004
Identities = 86/452 (19%), Positives = 156/452 (34%), Gaps = 78/452 (17%)
Query: 246 DVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIK-PNLSSSPRSEETTAS 304
+ + P E E +K EE + +E P ++K P + SP EE +
Sbjct: 591 EAKSPAEAKSPEKAKSPVK-EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS- 648
Query: 305 SLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPST 364
P A PE++ + +P + SPE + PV E P+
Sbjct: 649 ----PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV----KAEAKSPEKAKSPVKE 700
Query: 365 ESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVE 424
E+ S ++ + PE + +SP E ++ P K+ + + +
Sbjct: 701 EAKSPEKAKSPVKEEAKSPE---KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 425 SGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSID 484
+ D + KE + +P++ +A + + E + + +
Sbjct: 758 TLDVKSPEAKTPAKEEA----RSPADKFPEKAKSPVKE------------EVKSPEKAKS 801
Query: 485 SLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAK 544
L+E D K K+ P+ + ++S + + + + PK K
Sbjct: 802 PLKE--DAKAPEKEIPKKEE--VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 545 RSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKN 604
SKKE P PK +E+ ++P+V E+P E E +
Sbjct: 858 DSKKEEAPKKEAPK---------PKVEEKKEPAV-EKPKESKVEAK-------------- 893
Query: 605 MLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESI-ACKRDPE 663
KE E + ++ P P + V+ K D K P E K++P+
Sbjct: 894 ---KEEAEDKKKV------------PTPEKEAPAKVEVKEDAK----PKEKTEVAKKEPD 934
Query: 664 QAKEEPGHIPTQHVEEAVNEVDNENTQQKDDE 695
AK + P + E A + D + + K E
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE 966
Score = 36.6 bits (83), Expect = 0.15
Identities = 49/225 (21%), Positives = 86/225 (38%), Gaps = 22/225 (9%)
Query: 250 PREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEV--CPTKIKPNLS-SSPRSEETTASSL 306
P +++ + P KEI EE V ++PQE +V P K + + ++P++EE S
Sbjct: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
Query: 307 VWPLPAHLPEEDLPEGGS-TVSAPTASGMSSPEHNQPPVALLDTEEMSVP------QDCH 359
P+ + E V P S + + + + T E P +D
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 360 LLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKA-EDNQS 418
TE + P P E + ++ + + E P + KA ED+++
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981
Query: 419 ISAEVESGDTQELNVDPLLKESSTFTDEN----PSETEESEAAGG 459
+S E ++ E S+ TD+ P + E +AA G
Sbjct: 982 LSKEPSKPKAEK-------AEKSSSTDQKDSKPPEKATEDKAAKG 1019
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 62.4 bits (150), Expect = 3e-09
Identities = 215/1105 (19%), Positives = 377/1105 (34%), Gaps = 205/1105 (18%)
Query: 231 TPKQTLTIPAPRHTVDVQLPREDNPEE--PSKEITSHEEGGGDVSPRKEPQEPEVCPTKI 288
TP + +I +P+ P+ + E P E+ S S P+ P +
Sbjct: 848 TPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQ 907
Query: 289 KPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLD 348
P+ SSSP+ + S P + G S+ S + ++P ++ +
Sbjct: 908 SPSRSSSPQPKVKAIIS---------PRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSN 958
Query: 349 TEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPP-EIVSREESPQCSENQSSPMGLEPP 407
E +P+ H SG S D +P +PP + S SP +P G P
Sbjct: 959 VESRLLPRYSH--------SGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG--PS 1008
Query: 408 MSLGKAEDNQSISAEVESGDTQELNVDPLLKE---SSTFTDENPSETEESEAAGGIGKLE 464
+S K S QE + D L++ S + S T E+ G+ L+
Sbjct: 1009 LSGSK------------SPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQ 1056
Query: 465 GEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSD--SSSADRCLR 522
+ + DTS + ++ + + + S + RS+ S + A R
Sbjct: 1057 LKGQSQTSPDHRS--DTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPI 1114
Query: 523 NQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNER- 581
Q SA +K +P R + + T L ET E EK ++ +
Sbjct: 1115 RQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQE 1174
Query: 582 ------PSEKDA-----EQEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQP 630
P +KD Q+ ++ + TL+ P R+ P
Sbjct: 1175 DATASPPRQKDKFSPFPVQDRPESSLVFKDTLRT--------------PPRERSGAGSSP 1220
Query: 631 LPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQ 690
E+ S DE+ + +S EEP H+ + E+ N +
Sbjct: 1221 ETKEQNSALPTSSQDEELMEVVEKS-----------EEPAGQILSHLSSELKEMSTSNFE 1269
Query: 691 QKDDESDAPCSSLGLSSSGSGDAARA------------PKSVPRPKRLTSSTYN------ 732
+ + P SL L S S + A P P K L++S
Sbjct: 1270 SSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGS 1329
Query: 733 ---LRHAHSLGSLDASKVTSEKEAAQVNPIMP----------KENGASESGDPLDEDDVD 779
R++ LG+ + +SE + P + KE SG E D
Sbjct: 1330 PLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPD 1389
Query: 780 TVVDE--------QPKFMEWCAEEENQELIANFNAQYMK----------VQKGWIQLEKE 821
V ++ ++E ++ ++ MK + G ++
Sbjct: 1390 AVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRD 1449
Query: 822 GQPTPRARNKSDK---LKEIWKSKKRSR-KCRSSLESQKCSPV---QMLFMTNFKLSNVC 874
G TP + S +K+I ++ R R +C SS E + + ++ +L+N C
Sbjct: 1450 GSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKC 1509
Query: 875 KWFLETTETRSLVIVKKLNTRLPG------------DVPPVKHPLQKYAPSSLYPSSLQA 922
+ +K R P DV P P Q+ + S P S
Sbjct: 1510 LTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASP-QERSESDSSPDSKAK 1568
Query: 923 ERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKED 982
R + G++P ++ K R +P + +V P + +
Sbjct: 1569 TRTPLRQRSRSGSSPEVDS--------KSRLSPRRSRSGSSPEVKDKPRAAP---RAQSG 1617
Query: 983 RNSHPPANLPTP-ASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCI 1041
+S P P P A R R S+ +G+ + + E + E P ++
Sbjct: 1618 SDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTES-------SPEHPPKSRTARR 1670
Query: 1042 NPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSK 1101
SP+ K KS + R + E+ KA + S+R R+ SSP
Sbjct: 1671 GSRSSPE-----------PKTKSRTPPRRRSSRSSPELTRKARL-SRRSRSASSSPETRS 1718
Query: 1102 NKGPTVKASKEKHADGATKTPAAKRPAARDR--SSQPPKKTSLKENKVKIPK-KSAGKSC 1158
P + S ++ PA K ++R R +S P KT+ + + PK + +S
Sbjct: 1719 RTPPRHRRSPSV----SSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSR 1774
Query: 1159 PPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKT 1218
SR+EK T +R +S +S++ T+R++ ++R+R + +
Sbjct: 1775 SRSRREKTRTTRRRDRSGSSQS--------------------TSRRRQRSRSRSRVTRRR 1814
Query: 1219 PESSAAQRKRKLKAKLDCSHSKRRR 1243
S + + + + S+RRR
Sbjct: 1815 RGGSGYHSRSPARQESSRTSSRRRR 1839
Score = 49.3 bits (116), Expect = 2e-05
Identities = 75/356 (21%), Positives = 127/356 (35%), Gaps = 32/356 (8%)
Query: 897 PGDVPPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPD 956
P PP + L + + SS P+ Q ++ KK K + + + + +K +K +++
Sbjct: 163 PAPEPPKPYSLVRESSSSRSPTPKQKKKKKK--KDRGRRSESSSPRRERKKSSKKKKHRS 220
Query: 957 QVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRL 1016
+ E + SP P S+ ++ K R+ + P P S R R S R
Sbjct: 221 ESESKKRKHRSPTPKSKRKSKDKKRKRSR---STTPAPKSRRAHRSTSADSASSSDTSRS 277
Query: 1017 IKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKG--- 1073
A+ + SP + + D +P +T +
Sbjct: 278 RSRSAAAKTHTTALAGRSP----------SPASGRRGEGDAPFSEPGTTSTQRPSSPETA 327
Query: 1074 -KQVSEILPKAEVQSKRKRTEGSSP-PDSKNKGPTVKASK----EKHADGA---TKTPAA 1124
KQ S + K K SP P+ + GP A E+H TP +
Sbjct: 328 TKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLS 387
Query: 1125 KRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKP 1184
+ P + P + S ++ K+P+ S+ +S PPS K + +S KP
Sbjct: 388 QEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPS----PQPTKVSRHASSSPESPKP 443
Query: 1185 AKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSK 1240
A G+ S + NR K R + + TP + + AK S S+
Sbjct: 444 APAPGSHREISSSPTSKNRSHGRAK-RDKSHSHTPSRRMGRSRSPATAKRGRSRSR 498
Score = 47.4 bits (111), Expect = 9e-05
Identities = 58/252 (23%), Positives = 104/252 (41%), Gaps = 26/252 (10%)
Query: 1004 SNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPK 1063
S + K R QR ++ + S+ SR +L+L+ G PK
Sbjct: 728 SERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPK 787
Query: 1064 STEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPA 1123
R+ + S PKA+ ++ +R+ SS P K K T S++ H+ +
Sbjct: 788 QKSQTPPRRSRSGSS-QPKAKSRTPPRRSRSSSSPPPKQKSKT--PSRQSHSSSS----- 839
Query: 1124 AKRPAARDRSSQPPKK---TSLKENKVKI-PKKSAGKSCPPSRKEKENTNKRPSQSIASE 1179
P + +S PP++ TS + N+ + P++ + P + K T R S S +S
Sbjct: 840 ---PHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSP 896
Query: 1180 TLTK---PAKQKGAGESSSRPQK----ATNRKQSSGKTRARPSTKTPESSAAQRKRKLKA 1232
K P +Q + SS +P+ + ++ SG + PS T ++ R+ ++
Sbjct: 897 PRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTT----PRRSRS 952
Query: 1233 KLDCSHSKRRRL 1244
CS+ + R L
Sbjct: 953 VSPCSNVESRLL 964
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/150 (26%), Positives = 65/150 (43%), Gaps = 21/150 (14%)
Query: 1112 EKHADGATKTPAAKRPAARDRSSQPPKKTSL-----------KENKVKIPKKSAGK---S 1157
+ + DG++ P + A+ + +PPK SL + K K KK G+ S
Sbjct: 143 DSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSES 202
Query: 1158 CPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTK 1217
P R+ K+++ K+ + SE+ +K K + S R K RK+S T A S +
Sbjct: 203 SSPRRERKKSSKKKKHR---SESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRR 259
Query: 1218 TPESSAAQRKRKLKAKLDCSHSKRRRLDAK 1247
S++A + D S S+ R AK
Sbjct: 260 AHRSTSADS----ASSSDTSRSRSRSAAAK 285
Score = 40.8 bits (94), Expect = 0.008
Identities = 92/435 (21%), Positives = 156/435 (35%), Gaps = 55/435 (12%)
Query: 820 KEGQPTPRARNKSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVC---KW 876
K T + R++S+ E+ KS+ SR+ RS + + ++ + S+ C K
Sbjct: 731 KNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKS 790
Query: 877 FLETTETRSLVIVKKLNTRLP------GDVPPVKHPLQKYAPSSLYPSSLQAERLKKHLK 930
+RS K +R P PP P QK S PS H K
Sbjct: 791 QTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPP---PKQK----SKTPSRQSHSSSSPHPK 843
Query: 931 KFPGATPAKNNWKMQKLWAKFRENPDQVEPEDGS--DVSPGPNSEDSIEEVKEDRNSHPP 988
G P + + + N V P+ S + SP P + S PP
Sbjct: 844 VKSGTPPRQGSITSP------QANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPP 897
Query: 989 ----ANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPL 1044
+ P + +R ++ + +QR P + + P R+S ++P
Sbjct: 898 RVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTP-RRSRSVSPC 956
Query: 1045 MSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQ---SKRKRTEGSSPPDSK 1101
+ + L + S G K E P+ S + + +PP
Sbjct: 957 SNVESRL--------LPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPS 1008
Query: 1102 NKGPTVKASKEKHADGATKT-PAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPP 1160
G +EK D ++ P + A +SS PP ++ + +++ K ++ P
Sbjct: 1009 LSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQL--KGQSQTSPD 1066
Query: 1161 SRKEKENTNKRPSQ----SIASETLTKPAKQKGAGESSSRPQKATNR---KQSSGKTRAR 1213
R + + R S S+ S++ T P + G SSS + +R +Q G+ A
Sbjct: 1067 HRSDTSSPEVRQSHSESPSLQSKSQTSP--KGGRSRSSSPVTELASRSPIRQDRGEFSAS 1124
Query: 1214 PSTK---TPESSAAQ 1225
P K +PE S Q
Sbjct: 1125 PMLKSGMSPEQSRFQ 1139
Score = 40.4 bits (93), Expect = 0.011
Identities = 43/220 (19%), Positives = 83/220 (37%), Gaps = 16/220 (7%)
Query: 1018 KNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKP----KSTEGMKGRKG 1073
K + + + S S S + S + + PV+P K
Sbjct: 2528 KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587
Query: 1074 KQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRS 1133
+ V E P +KRKR SS S + + +S + ++ + ++ ++ S
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 1134 SQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNK-----RPSQSIASETL--TKPAK 1186
S P K + +PK ++ K PP + + K R S+S++ + +P+
Sbjct: 2648 SPSPAKPGPQA----LPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSP 2703
Query: 1187 QKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQR 1226
Q + S + +R+ G +R+ PS K + + R
Sbjct: 2704 QPSPRDQQSSSSERGSRRGQRGDSRS-PSHKRRRETPSPR 2742
Score = 39.7 bits (91), Expect = 0.018
Identities = 37/154 (24%), Positives = 62/154 (40%), Gaps = 3/154 (1%)
Query: 289 KPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLD 348
+P +S+ R ++ P ++D E +T +P+ S+ P LL
Sbjct: 312 EPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLA 371
Query: 349 TEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEP-P 407
PQ P ++ SE +R SPP+ S E+ PQ S ++SSP +P
Sbjct: 372 ERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPK--SPEKLPQSSSSESSPPSPQPTK 429
Query: 408 MSLGKAEDNQSISAEVESGDTQELNVDPLLKESS 441
+S + +S G +E++ P K S
Sbjct: 430 VSRHASSSPESPKPAPAPGSHREISSSPTSKNRS 463
Score = 38.5 bits (88), Expect = 0.040
Identities = 30/148 (20%), Positives = 63/148 (42%), Gaps = 11/148 (7%)
Query: 1089 RKRTEGSSPP----DSKNKGPTVKASKEKHADGATK------TPAAKRPAARDRSSQPPK 1138
R+R+ +PP S+++ PT + T+ TP R +R R+S +
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITR 1979
Query: 1139 KTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQ 1198
+ S ++S ++ P +R+ + + P S + T PA ++ + +
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRR-RSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLP 2038
Query: 1199 KATNRKQSSGKTRARPSTKTPESSAAQR 1226
+ +R +S R R ++TP ++ +R
Sbjct: 2039 RKRSRSRSPLAIRRRSRSRTPRTARGKR 2066
Score = 37.4 bits (85), Expect = 0.090
Identities = 30/153 (19%), Positives = 64/153 (41%), Gaps = 19/153 (12%)
Query: 1082 KAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTS 1141
+ V +R R+ S +++ T ++ + ++TP +R R RS PP
Sbjct: 1903 RTSVTRRRSRSRASPVSRRRSRSRTPPVTRRR---SRSRTPTTRR---RSRSRTPP---- 1952
Query: 1142 LKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKAT 1201
+ ++ + PP + + + P S + T P ++ + +S +
Sbjct: 1953 -------VTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRR 2005
Query: 1202 NRKQSSGKTRARPSTKTPESSAAQRKRKLKAKL 1234
+R ++S TR R ++TP A +R+ + + L
Sbjct: 2006 SRSRTSPVTRRRSRSRTP--PAIRRRSRSRTPL 2036
Score = 37.0 bits (84), Expect = 0.12
Identities = 33/182 (18%), Positives = 69/182 (37%), Gaps = 13/182 (7%)
Query: 1051 LQVDADGFPVK-----PKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGP 1105
L V A G P P ST + + + S + SS S +
Sbjct: 2494 LSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSS 2553
Query: 1106 TVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEK 1165
+ S ++G++ + R S P K +++E + P P+++++
Sbjct: 2554 SSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPT--------PAKRKR 2605
Query: 1166 ENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQ 1225
+++ S S +S + + + + SSS +++ SS + A+P + A+
Sbjct: 2606 RSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP 2665
Query: 1226 RK 1227
+K
Sbjct: 2666 KK 2667
Score = 36.6 bits (83), Expect = 0.15
Identities = 40/184 (21%), Positives = 79/184 (42%), Gaps = 40/184 (21%)
Query: 1082 KAEVQSKRKRTEGSSPPD--SKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKK 1139
++ ++R R+ +P S+++ PT + S+ ++TPA + R RS P ++
Sbjct: 574 RSRTPARRGRSRSRTPARRRSRSRTPTRRRSR-------SRTPARR---GRSRSRTPARR 623
Query: 1140 TSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK----------PAKQKG 1189
S + + P + +S P+R+ + ++ P++ S + T PA++ G
Sbjct: 624 RS----RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG 679
Query: 1190 ---------AGESSSRPQKATNRKQSSGKTRARPSTKTPE-----SSAAQRKRKLKAKLD 1235
G S SR + + S R R ++TP+ S+++RK K +
Sbjct: 680 RSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR 739
Query: 1236 CSHS 1239
S S
Sbjct: 740 RSRS 743
Score = 36.2 bits (82), Expect = 0.20
Identities = 37/183 (20%), Positives = 73/183 (39%), Gaps = 16/183 (8%)
Query: 1042 NPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSK 1101
+P +PK A++ +G P P+ T + R+ S + S + SS S
Sbjct: 2581 SPTPAPKEAVR---EGRP--PEPTPAKRKRRSSSSS-----SSSSSSSSSSSSSSSSSSS 2630
Query: 1102 NKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSA-----GK 1156
+ + +S + ++ +PA P A + + P KK E + + P+K +
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP-KKPPPGERRSRSPRKPIDSLRDSR 2689
Query: 1157 SCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPST 1216
S S E+ + +PS + ++ ++G S P R+ S + S+
Sbjct: 2690 SLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSS 2749
Query: 1217 KTP 1219
++P
Sbjct: 2750 RSP 2752
Score = 35.4 bits (80), Expect = 0.34
Identities = 90/447 (20%), Positives = 173/447 (38%), Gaps = 49/447 (10%)
Query: 820 KEGQPTPRARNKSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLE 879
K PTP+++ KS K KKR R RS+ + K + S+ +
Sbjct: 228 KHRSPTPKSKRKS-------KDKKRKRS-RSTTPAPKSRRAHRSTSADSASSS------D 273
Query: 880 TTETRSLVIVKKLNTR-LPGDVPPVKHPLQKY--AP-SSLYPSSLQAERLKKHLKKFPGA 935
T+ +RS K +T L G P + AP S +S Q + K P +
Sbjct: 274 TSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQP-S 332
Query: 936 TPAKNNWKMQKLWAKFRENPDQVEPEDGSDV-SPGPNSED----SIEEVKEDRNSHPPAN 990
+P ++ K +K + R +P G + +P P + S + + S P N
Sbjct: 333 SPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVN 392
Query: 991 LPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSR--KSVCINPLMSPK 1048
P+ AS + R ++ ++L ++ E +K SR S +P +P
Sbjct: 393 PPSEASP------TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPA 446
Query: 1049 LALQVDADGFPVKPKSTEGMKGRKGKQVSEI------LPKAEVQSKRKRTEGSSPPD--- 1099
+ P + G + ++ K S ++ +KR R+ +P
Sbjct: 447 PGSHREISSSPTSKNRSHG-RAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGH 505
Query: 1100 SKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCP 1159
S+++ P + S+ G +++P + R RS Q P + + + + +SA +
Sbjct: 506 SRSRSPQWRRSRSAQRWGRSRSPQRR---GRSRSPQRPGWSRSRNTQRRGRSRSARRGRS 562
Query: 1160 PSRKEKENTNKR---PSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPST 1216
SR R P++ S + T PA+++ + +R + + G++R+R
Sbjct: 563 HSRSPATRGRSRSRTPARRGRSRSRT-PARRRSRSRTPTRRRSRSRTPARRGRSRSRTPA 621
Query: 1217 KTPESSAAQRKRKLKAKLDCSHSKRRR 1243
+ + + +R+ +++ S R R
Sbjct: 622 RRRSRTRSPVRRRSRSRSPARRSGRSR 648
Score = 34.3 bits (77), Expect = 0.76
Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 1089 RKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVK 1148
R+R+ + P ++ + + + S ++TP A R +R R+ P+K S + +
Sbjct: 1991 RRRSRSRTSPVTRRRSRS-RTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLA 2049
Query: 1149 IPKKSAGKSCPPSRKEKENTNKRP---------SQSIASETLTKPAKQKGAGESSSRPQK 1199
I ++S ++ +R ++ T P S S S + T PA + +G S P
Sbjct: 2050 IRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSG--SRTPPV 2107
Query: 1200 ATNRKQSS 1207
A N + S
Sbjct: 2108 ALNSSRMS 2115
Score = 33.9 bits (76), Expect = 1.00
Identities = 63/302 (20%), Positives = 106/302 (35%), Gaps = 23/302 (7%)
Query: 268 GGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVS 327
G SPR E + P L RS ++ P + + E P S +
Sbjct: 2377 GANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSA----PSQSRMTSERAPSPSSRMG 2432
Query: 328 APTASGMSSPEHNQP----PVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISR-PHSP 382
+ + P +QP P A D + Q + S SG V+ S H+
Sbjct: 2433 QAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNG 2492
Query: 383 PEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISA-----EVESGDTQELNVDPLL 437
V P S +G EPP S G A+ +++A E S + +
Sbjct: 2493 MLSVPAPGVPH------SDVG-EPPASTG-AQQPSALAALQPAKERRSSSSSSSSSSSSS 2544
Query: 438 KESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSI-DSLEENLDKKKKG 496
SS+ + + S + S++ G ++ E + S ++ + K+
Sbjct: 2545 SSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRK 2604
Query: 497 KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTT 556
++ +S S S SSS+ + SS SSS+ +PS + + P +
Sbjct: 2605 RRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPAS 2664
Query: 557 PK 558
PK
Sbjct: 2665 PK 2666
Score = 32.3 bits (72), Expect = 2.9
Identities = 24/143 (16%), Positives = 60/143 (41%), Gaps = 10/143 (6%)
Query: 1089 RKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVK 1148
R+R+ +PP ++ + + + + + +P +R +R R+S ++ S
Sbjct: 1955 RRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR-RSRSRTSPVTRRRSRSRTSPV 2013
Query: 1149 IPKKSAGKSCPPSRKE---------KENTNKRPSQSIASETLTKPAKQKGAGESSSRPQK 1199
++S ++ P R+ ++ + R +I + ++ + S +R
Sbjct: 2014 TRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPP 2073
Query: 1200 ATNRKQSSGKTRARPSTKTPESS 1222
A R+ +SG + R + TP ++
Sbjct: 2074 AIRRRSASGSSSDRSRSATPPAT 2096
Score = 31.2 bits (69), Expect = 6.5
Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 8/116 (6%)
Query: 239 PAPRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRS 298
PAP+ V RE P EP+ S + + SSS S
Sbjct: 2584 PAPKEAV-----REGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638
Query: 299 EETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMS-SPEHNQPPVALLDTEEMS 353
+++SS P PA + LP+ S P S SP +P +L D+ +S
Sbjct: 2639 SSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP--RKPIDSLRDSRSLS 2692
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 57.0 bits (136), Expect = 1e-07
Identities = 195/1004 (19%), Positives = 359/1004 (35%), Gaps = 135/1004 (13%)
Query: 267 EGGGDVSPRKE-PQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGST 325
+G G V P K P P K + + SS SEE++ SS A P ++ G
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESS--SEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 326 VSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPP-- 383
+ PT+S P PVA+ E + S++S + ++ + P
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 384 EIVSREESPQCSENQSSP------MGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL 437
+I + P+ + +S +G + P G A S V G +
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA------ 690
Query: 438 KESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGK 497
E S+ ++E+ SE E++ A +G+ + K L K SL + GK
Sbjct: 691 -EDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 498 KFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGT-- 555
P + Q SS + + S +++++ ++K S K+++ + +P
Sbjct: 747 TGPTVTQVKAEKQEDSESSEEE---SDSEEAAASPAQVKT----SVKKTQAKANPAAARA 799
Query: 556 -TPKGLL--PDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITR--QTLKNMLDKEV 610
+ KG + P T + ++ +P ++ + ++ R ++ ++
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST----VLARGPASVPSVGKAVA 855
Query: 611 KELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQ--AKEE 668
+ + P D ++ + E E Q K K I + K P + A
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 669 PGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGL------------SSSGSGDAARA 716
PG + + ++++ D + +AP + + S +G AA
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 975
Query: 717 PK----SVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDP 772
+ S PR R + ST A +SE E V P A++ P
Sbjct: 976 AQAQAASTPRKARASEST-------------ARSSSSESEDEDVIP-------ATQCLTP 1015
Query: 773 LDEDDVDTVVDEQPKF-----MEWCAEEENQELIANFNAQYMKVQK-----GWIQLEKEG 822
+V T+ P+ M + + I++ Q + G +
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 823 QPTPRARN----KSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFL 878
+ +A+ + KL E+ ++ K S +S S + + +
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 879 ETTETRSLVIVKKLNTRLPGD--VPPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGAT 936
T +R+ +V++ D V P + L Y L P++ QA + L P +
Sbjct: 1136 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1195
Query: 937 PAKNNWKMQKLWAKFRENPD---QVEPEDGSDV-SPGPNSEDSIEEVKEDRNSHPPANLP 992
L AK ++PD + +P+ + + SP +++ ++ P
Sbjct: 1196 ST--------LAAK--DDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAG 1245
Query: 993 TP-ASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLAL 1051
P AST L+ SNI L Q + +++ A V+ + L+ +
Sbjct: 1246 NPQASTLALQ--SNITQCLLGQPWPLNEAQVQ---ASVVK--------VLTELLEQERKK 1292
Query: 1052 QVDADGFPVKPKSTEGMKGRK----GKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTV 1107
VD K S +G + RK G Q + P+++ + K EG S K T
Sbjct: 1293 VVDT----TKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT 1348
Query: 1108 KASKEKH--ADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEK 1165
K K A G K K + P++ L++ + + +S P S+KEK
Sbjct: 1349 SKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEE-ELQKGMGTV--EGGDQSNPKSKKEK 1405
Query: 1166 ENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGK 1209
+ ++KR E K AK+ +S S QK +K+ + +
Sbjct: 1406 KKSDKRKKDKEKKEK-KKKAKKASTKDSESPSQKKKKKKKKTAE 1448
Score = 43.9 bits (102), Expect = 0.001
Identities = 64/304 (21%), Positives = 115/304 (37%), Gaps = 27/304 (8%)
Query: 956 DQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRG-KLRAQQ 1014
D D +DV P+ + + + PA PA ++ ++G L +
Sbjct: 202 DTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAK 261
Query: 1015 RLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMK----G 1070
R K E+ ES+ + + + + + LQV A P K +G G
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 1071 RKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAAR 1130
+ G S+ + +E SS DS+ + P KA + A G T A
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESS--DSEEETPAAKALLQAKASGKTSQVGA------ 373
Query: 1131 DRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK---PAKQ 1187
+ P K S ++ P GK+ P K + + SQS + E+ ++ PA+
Sbjct: 374 ---ASAPAKESPRKGAAPAPP---GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQA 427
Query: 1188 KGAGE-----SSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRR 1242
K +G+ ++S P K + RK ++ + + +++ ++ + S S R
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 1243 RLDA 1246
L A
Sbjct: 488 ALAA 491
Score = 40.0 bits (92), Expect = 0.014
Identities = 111/577 (19%), Positives = 187/577 (32%), Gaps = 100/577 (17%)
Query: 289 KPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLD 348
KP S SEE++ S P L + S V A +A SP P
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Query: 349 TEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQ-------CSENQSSP 401
T E S SE+ S +P + ++PQ E+
Sbjct: 394 TGPAVAKAQA---GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 450
Query: 402 MGLEPPMSLGKA----------EDNQSISAEVES----------GDTQELNVDPLLKESS 441
PP G A ED++S S E +S + L P +K +S
Sbjct: 451 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAS 510
Query: 442 TF---------TDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDK 492
T P + + + +GK E ED + D+ D + + +
Sbjct: 511 TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE-EDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 493 KKKG-----------------KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL-- 533
K G K P A + +S S++ + S+ + A +
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 534 -----EIKVPKNPSAKRSKKEGHPGGTTPKGL---LPDSFHTETLEDTEKPSV---NERP 582
+K+P+ + + P + P T T P+V +RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 583 S-------EKDAEQEGEGGGIITRQTLKNMLDKEVK----ELRGEIFPSRDPITTAGQPL 631
+ E D+E+E G + Q +VK ++G + P+ L
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV------L 743
Query: 632 PGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQ 691
PG+ Q K +++ SES + D E+A P + T V +
Sbjct: 744 PGKTGPTVTQVKAEKQE---DSESSEEESDSEEAAASPAQVKT--------SVKKTQAKA 792
Query: 692 KDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEK 751
+ AP + +S+ G A A P ++ N +++ L AS + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 752 EAAQVNPIM--PKENGASESGDPLDEDDVDTVVDEQP 786
A P+E+ S + E++ +T+ +P
Sbjct: 853 AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP 889
Score = 33.1 bits (74), Expect = 1.7
Identities = 36/146 (24%), Positives = 53/146 (36%), Gaps = 26/146 (17%)
Query: 1079 ILPKAEVQSKRKRTEGSSPPDSKNK-GPTVKASKEKHADGATKTPAAKRPAARDRSSQPP 1137
I PKA + E S D K + GP + D A T PA +S+
Sbjct: 1031 IAPKASMAGASSSKESSRISDGKKQEGPATQV------DSAVGT----LPATSPQSTSVQ 1080
Query: 1138 KKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRP 1197
K + K K K+P+ P S + E+++ S G+ E P
Sbjct: 1081 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS---------------GSEEDGEGP 1125
Query: 1198 QKATNRKQSSGKTRARPSTKTPESSA 1223
Q A + G T +R T E++A
Sbjct: 1126 QGAKSAHTLVGPTPSRTETLVEETAA 1151
Score = 31.6 bits (70), Expect = 4.9
Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 15/197 (7%)
Query: 1046 SPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKA-EVQSKRKRTEGSSPPDSKNKG 1104
SP+ + + A+ V EG G + A + S + T SS
Sbjct: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGK 215
Query: 1105 PTVKASKEKHADGATKTPAAKRPA-----ARDRSSQPPKKTSLKENKVKIPKKSAGKSCP 1159
P+VK ++ K + +TK A++ A D + Q + K P++ + S
Sbjct: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
Query: 1160 PSRKEKENTNKRPSQSIASETL------TKPAK-QKGAGESSSRPQK--ATNRKQSSGKT 1210
S E+E SQ ASE + + PAK G G + + P K A + +GK
Sbjct: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
Query: 1211 RARPSTKTPESSAAQRK 1227
+ + ESS ++ +
Sbjct: 336 EEDSESSSEESSDSEEE 352
Score = 30.8 bits (68), Expect = 8.4
Identities = 63/305 (20%), Positives = 96/305 (31%), Gaps = 48/305 (15%)
Query: 935 ATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPAN---- 990
A P K + K A RE Q E+ P + + R + PA
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448
Query: 991 ---LPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSP 1047
P P GK R E +ALA + K + +P
Sbjct: 449 KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP---- 504
Query: 1048 KLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTV 1107
VKP ST GM G GK + P + G DS++
Sbjct: 505 -----------QVKPASTMGM-GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES----- 547
Query: 1108 KASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKEN 1167
+S+E + P A PA +++S + + K P + AG + EK
Sbjct: 548 -SSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 605
Query: 1168 TNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRK 1227
N S+ + + +S P T +A+P+ K P++ A +K
Sbjct: 606 DNSESSE-----------ESSDSADSEEAPAAMT-------AAQAKPALKIPQTKACPKK 647
Query: 1228 RKLKA 1232
A
Sbjct: 648 TNTTA 652
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 55.8 bits (133), Expect = 2e-07
Identities = 206/1024 (20%), Positives = 356/1024 (34%), Gaps = 176/1024 (17%)
Query: 267 EGGGDVSPRKE-PQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGST 325
+G G V P K P P K + + SS SEE++ SS A P ++ G
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESS--SEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 326 VSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPP-- 383
+ PT+S P PVA+ E + S++S + ++ + P
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 384 EIVSREESPQCSENQSSP------MGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL 437
+I + P+ + +S +G + P G A S V G +
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA------ 690
Query: 438 KESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGK 497
E S+ ++E+ SE E++ A +G+ + K L K SL + GK
Sbjct: 691 -EDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 498 KFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPK-----NPSAKRSK----- 547
P + Q DS S++ ++ + +S A ++ V K NP+A R+
Sbjct: 747 TGPTVTQVKAEKQ-EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 548 --------------KEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNER----------PS 583
K+ P P P + PSV + P
Sbjct: 806 ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
Query: 584 EKDAEQEGEGGGIITRQTLKNMLDK-EVKELRGEIFPSRDPITTAGQPLP---------- 632
E E E +TL + + ++R + P+++ P P
Sbjct: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 633 -GERLEIYVQSKMDEKNAHIPSESIACKR--------DPEQAKEEPGHIPTQHVEEAVNE 683
G++ + S+ + + P+ + + DP ++ P P Q +
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQA------Q 979
Query: 684 VDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLD 743
+ + + ES A SS S S D A + + R T H
Sbjct: 980 AASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Query: 744 ASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQELIAN 803
+ +S KE+++++ +E A++ VD+ V P
Sbjct: 1037 MAGASSSKESSRISDGKKQEGPATQ---------VDSAVGTLPAT--------------- 1072
Query: 804 FNAQYMKVQ-KGWIQLEK----EGQPTPRARNKSDKLKEIWKSKKRSRKCRSSLESQKCS 858
+ Q VQ KG +L K E Q +A SD ++ S S + + K +
Sbjct: 1073 -SPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1131
Query: 859 PVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGD--VPPVKHPLQKYAPSSLY 916
L T +R+ +V++ D V P + L Y L
Sbjct: 1132 HT-----------------LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLT 1174
Query: 917 PSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPD---QVEPEDGSDV-SPGPNS 972
P++ QA + L P + L AK ++PD + +P+ + + SP
Sbjct: 1175 PANSQASKATPKLDSSPSVSST--------LAAK--DDPDGKQEAKPQQAAGMLSPKTGG 1224
Query: 973 EDSIEEVKEDRNSHPPANLPTP-ASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVE 1031
+++ ++ P P AST L+ SNI L Q + +++ A V+
Sbjct: 1225 KEAASGTTPQKSRKPKKGAGNPQASTLALQ--SNITQCLLGQPWPLNEAQVQ---ASVVK 1279
Query: 1032 SKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRK----GKQVSEILPKAEVQS 1087
+ L+ + VD K S +G + RK G Q + P+++ +
Sbjct: 1280 --------VLTELLEQERKKVVDT----TKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1327
Query: 1088 KRKRTEGSSPPDSKNKGPTVKASKEKH--ADGATKTPAAKRPAARDRSSQPPKKTSLKEN 1145
K EG S K T K K A G K K + P++ L++
Sbjct: 1328 KLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEE-ELQKG 1386
Query: 1146 KVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQ 1205
+ + +S P S+KEK+ ++KR E K AK+ +S S QK +K+
Sbjct: 1387 MGTV--EGGDQSNPKSKKEKKKSDKRKKDKEKKEK-KKKAKKASTKDSESPSQKKKKKKK 1443
Query: 1206 SSGK 1209
+ +
Sbjct: 1444 KTAE 1447
Score = 43.9 bits (102), Expect = 0.001
Identities = 64/304 (21%), Positives = 115/304 (37%), Gaps = 27/304 (8%)
Query: 956 DQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRG-KLRAQQ 1014
D D +DV P+ + + + PA PA ++ ++G L +
Sbjct: 202 DTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAK 261
Query: 1015 RLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMK----G 1070
R K E+ ES+ + + + + + LQV A P K +G G
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 1071 RKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAAR 1130
+ G S+ + +E SS DS+ + P KA + A G T A
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESS--DSEEETPAAKALLQAKASGKTSQVGA------ 373
Query: 1131 DRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK---PAKQ 1187
+ P K S ++ P GK+ P K + + SQS + E+ ++ PA+
Sbjct: 374 ---ASAPAKESPRKGAAPAPP---GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQA 427
Query: 1188 KGAGE-----SSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRR 1242
K +G+ ++S P K + RK ++ + + +++ ++ + S S R
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 1243 RLDA 1246
L A
Sbjct: 488 ALAA 491
Score = 40.0 bits (92), Expect = 0.014
Identities = 111/577 (19%), Positives = 187/577 (32%), Gaps = 100/577 (17%)
Query: 289 KPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLD 348
KP S SEE++ S P L + S V A +A SP P
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Query: 349 TEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQ-------CSENQSSP 401
T E S SE+ S +P + ++PQ E+
Sbjct: 394 TGPAVAKAQA---GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 450
Query: 402 MGLEPPMSLGKA----------EDNQSISAEVES----------GDTQELNVDPLLKESS 441
PP G A ED++S S E +S + L P +K +S
Sbjct: 451 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAS 510
Query: 442 TF---------TDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDK 492
T P + + + +GK E ED + D+ D + + +
Sbjct: 511 TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE-EDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 493 KKKG-----------------KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL-- 533
K G K P A + +S S++ + S+ + A +
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 534 -----EIKVPKNPSAKRSKKEGHPGGTTPKGL---LPDSFHTETLEDTEKPSV---NERP 582
+K+P+ + + P + P T T P+V +RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 583 S-------EKDAEQEGEGGGIITRQTLKNMLDKEVK----ELRGEIFPSRDPITTAGQPL 631
+ E D+E+E G + Q +VK ++G + P+ L
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV------L 743
Query: 632 PGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQ 691
PG+ Q K +++ SES + D E+A P + T V +
Sbjct: 744 PGKTGPTVTQVKAEKQE---DSESSEEESDSEEAAASPAQVKT--------SVKKTQAKA 792
Query: 692 KDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEK 751
+ AP + +S+ G A A P ++ N +++ L AS + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 752 EAAQVNPIM--PKENGASESGDPLDEDDVDTVVDEQP 786
A P+E+ S + E++ +T+ +P
Sbjct: 853 AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP 889
Score = 31.6 bits (70), Expect = 4.9
Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 15/197 (7%)
Query: 1046 SPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKA-EVQSKRKRTEGSSPPDSKNKG 1104
SP+ + + A+ V EG G + A + S + T SS
Sbjct: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGK 215
Query: 1105 PTVKASKEKHADGATKTPAAKRPA-----ARDRSSQPPKKTSLKENKVKIPKKSAGKSCP 1159
P+VK ++ K + +TK A++ A D + Q + K P++ + S
Sbjct: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
Query: 1160 PSRKEKENTNKRPSQSIASETL------TKPAK-QKGAGESSSRPQK--ATNRKQSSGKT 1210
S E+E SQ ASE + + PAK G G + + P K A + +GK
Sbjct: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
Query: 1211 RARPSTKTPESSAAQRK 1227
+ + ESS ++ +
Sbjct: 336 EEDSESSSEESSDSEEE 352
Score = 31.6 bits (70), Expect = 4.9
Identities = 43/182 (23%), Positives = 61/182 (33%), Gaps = 25/182 (13%)
Query: 1079 ILPKAEVQSKRKRTEGSSPPDSKNK-GPTVKASKEKHADGATKTPAAKRPAARDRSSQPP 1137
I PKA + E S D K + GP + D A T PA +S+
Sbjct: 1031 IAPKASMAGASSSKESSRISDGKKQEGPATQV------DSAVGT----LPATSPQSTSVQ 1080
Query: 1138 KKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRP 1197
K + K K K+P+ P S + E+++ S S + E P K A P
Sbjct: 1081 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSS--DSSSGSEEDGEGPQGAKSAHTLGPTP 1138
Query: 1198 QKATNRKQSSGKTRARPSTKTPESS------------AAQRKRKLKAKLDCSHSKRRRLD 1245
+ + + + P S A + K KLD S S L
Sbjct: 1139 SRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLA 1198
Query: 1246 AK 1247
AK
Sbjct: 1199 AK 1200
Score = 30.8 bits (68), Expect = 8.4
Identities = 63/305 (20%), Positives = 96/305 (31%), Gaps = 48/305 (15%)
Query: 935 ATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPAN---- 990
A P K + K A RE Q E+ P + + R + PA
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448
Query: 991 ---LPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSP 1047
P P GK R E +ALA + K + +P
Sbjct: 449 KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP---- 504
Query: 1048 KLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTV 1107
VKP ST GM G GK + P + G DS++
Sbjct: 505 -----------QVKPASTMGM-GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES----- 547
Query: 1108 KASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKEN 1167
+S+E + P A PA +++S + + K P + AG + EK
Sbjct: 548 -SSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 605
Query: 1168 TNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRK 1227
N S+ + + +S P T +A+P+ K P++ A +K
Sbjct: 606 DNSESSE-----------ESSDSADSEEAPAAMT-------AAQAKPALKIPQTKACPKK 647
Query: 1228 RKLKA 1232
A
Sbjct: 648 TNTTA 652
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 55.5 bits (132), Expect = 3e-07
Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 4/151 (2%)
Query: 1074 KQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRS 1133
KQV P + +++ S S + K K K ++ P + P +
Sbjct: 246 KQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
Query: 1134 SQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGES 1193
+QPPKK K+ V+ + S+ +S S +EK K P++++ S+ TKP K A ES
Sbjct: 306 TQPPKKAVEKQQPVESSEDSSDESDSSSEEEK----KPPTKAVVSKATTKPPPAKKAAES 361
Query: 1194 SSRPQKATNRKQSSGKTRARPSTKTPESSAA 1224
SS + + + ++ +TK + A
Sbjct: 362 SSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA 392
Score = 53.9 bits (128), Expect = 9e-07
Identities = 76/348 (21%), Positives = 133/348 (38%), Gaps = 44/348 (12%)
Query: 907 LQKYAPSSLYP---SSLQAERLKKHLKKFPGATPAKNN-------WKMQKLWAKFRENPD 956
+++ PS LYP L+ +L + KF AT A + W K + P+
Sbjct: 6 IRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPE 65
Query: 957 QVEPEDG------SDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKL 1010
+ +G + +SEDS EE +E + PPA + R+ K
Sbjct: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQG--PPAKKAAVPAKRVGLPPGKAAAK- 122
Query: 1011 RAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKG 1070
A + E + D + +P +K V P+ A P K KS++
Sbjct: 123 -ASESSSSEESSDDDDEEDQKKQPVQKGV------KPQAKA---AKAPPKKAKSSDSDSD 172
Query: 1071 RKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAAR 1130
+ K ++ + + +PP P + K + ++ + ++ +
Sbjct: 173 SSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEE 232
Query: 1131 DRSSQPPKKTSLKENKV-KIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKG 1189
++++ PKKT K+ V K P K+A P+RK +++ S S E KP K K
Sbjct: 233 EKAAATPKKTVPKKQVVAKAPVKAA---TTPTRK---SSSSEDSSSDEEEEQKKPMKNKP 286
Query: 1190 AGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCS 1237
SS P A K+S G P A ++++ +++ D S
Sbjct: 287 GPYSSVPPPSAPPPKKSLG--------TQPPKKAVEKQQPVESSEDSS 326
Score = 52.4 bits (124), Expect = 3e-06
Identities = 70/356 (19%), Positives = 132/356 (37%), Gaps = 19/356 (5%)
Query: 898 GDVPPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQ 957
G PP K ++ S SS +++ + KK P A + P +
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK--------ATTKPPPAK 356
Query: 958 VEPEDGSDVSPGPNSEDSIEEVK-----EDRNSHPPANLPTPASTRILRKYSNIRGKLRA 1012
E SD S +SED K ++ ++ P +PA + G +
Sbjct: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
Query: 1013 QQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPK-STEGMKGR 1071
R + E + + E K + P + K AL + A P + S+
Sbjct: 417 LTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSS 476
Query: 1072 KGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARD 1131
++ E K+ V+ K ++ G + P +K + K K + ++ ++ +++ +
Sbjct: 477 SSEEEEEKTSKSAVKKKPQKVAGGAAP---SKPASAKKGKAESSNSSSSDDSSEEEEEKL 533
Query: 1132 RSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAG 1191
+ P+ + K N GK+ S +E+E K+ + ++ K KQ A
Sbjct: 534 KGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE-KKKAAVVVSKSGSLKKRKQNEAA 592
Query: 1192 ESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLDAK 1247
+ + PQ + Q+ R + SS +R R+ + ++D S DAK
Sbjct: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVD-SRVADNSFDAK 647
Score = 41.6 bits (96), Expect = 0.005
Identities = 74/329 (22%), Positives = 120/329 (36%), Gaps = 70/329 (21%)
Query: 964 SDVSPGPNSEDSIEEV------KEDRNSHPPANLPTPASTRILRKYSNIRGKL----RAQ 1013
S S +S+DS EE K A P A+T RK S+ Q
Sbjct: 219 SSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQ 278
Query: 1014 QRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKG 1073
++ +KN+ + P +KS+ P PK A++ PV+ +
Sbjct: 279 KKPMKNKPGPYSSVPPPSAPPPKKSLGTQP---PKKAVEKQQ---PVESSEDSSDESDSS 332
Query: 1074 KQVSEILPKAEVQSK--------RKRTEGSSPPDSKN-----KGPTVKASKEKHADG--- 1117
+ + P V SK +K E SS + + P+ A K++
Sbjct: 333 SEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA 392
Query: 1118 -ATKTPAAKRPAA---------------RDRSSQPPKKTSLKENKVK------------- 1148
TK+PA K AA D SS + +S +E K K
Sbjct: 393 VTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452
Query: 1149 ----IPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRK 1204
+P K A + S + ++++ + S++ K QK AG + P K + K
Sbjct: 453 AALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG--GAAPSKPASAK 510
Query: 1205 QSSGKTRARPSTKTPESSAAQRKRKLKAK 1233
+ GK + S+ + +SS + + KLK K
Sbjct: 511 K--GKAESSNSSSSDDSS-EEEEEKLKGK 536
Score = 37.4 bits (85), Expect = 0.090
Identities = 34/162 (20%), Positives = 62/162 (38%), Gaps = 2/162 (1%)
Query: 1080 LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAA-RDRSSQPPK 1138
L A+V ++ + G +K K + + + + P AK+ A R PP
Sbjct: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
Query: 1139 KTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGA-GESSSRP 1197
K + K ++ ++S+ +K++ Q+ A++ K AK + +SSS
Sbjct: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
Query: 1198 QKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHS 1239
+ N+K + TK P A + K S S
Sbjct: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSS 219
Score = 35.0 bits (79), Expect = 0.45
Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 50/303 (16%)
Query: 525 SSDSSSACLEIKVPKNPSAKRS----KKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNE 580
SSDS + E + + P AK++ K+ G P G S E+ +D ++ +
Sbjct: 84 SSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKK 143
Query: 581 RPSEKDAEQEGEGGGIITRQTLKNMLDKEV-------KELRGEIFPSRDPITTAGQPLPG 633
+P +K + + + ++ + D + K + +I P T P P
Sbjct: 144 QPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPA 203
Query: 634 ERLEIYVQSKM-----------------DEKNAHIPSESIACKRDPEQAKEEPGHIPTQH 676
K +EK A P +++ K+ +A + PT+
Sbjct: 204 RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK 263
Query: 677 VEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPK---SVPRPKRLTSSTYNL 733
+ + +E +QK + P G SS +A PK PK+ +
Sbjct: 264 SSSSEDSSSDEEEEQKKPMKNKP----GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
Query: 734 RHAHSLGSLDASKVTSEKE----------AAQVNPIMPKENGASESGDPLDEDDVDTVVD 783
+ S D S +SE+E A P P + A S D D D + D
Sbjct: 320 ESSED--SSDESDSSSEEEKKPPTKAVVSKATTKP-PPAKKAAESSSDSSDSDSSED--D 374
Query: 784 EQP 786
E P
Sbjct: 375 EAP 377
Score = 31.6 bits (70), Expect = 4.9
Identities = 86/458 (18%), Positives = 151/458 (32%), Gaps = 61/458 (13%)
Query: 438 KESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCL---------SEKDTYDTSIDSLEE 488
K+ ++ +D S EE E G K L SE + + S D +E
Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138
Query: 489 NLDKKK----------KGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL--EIK 536
KK+ K K P + S SDSSS D +NQ + + + K
Sbjct: 139 EDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSD-SDSSSEDEPPKNQKPKITPVTVKAQTK 197
Query: 537 VPKNPSAKRSK----KEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGE 592
P P+ K K ++ D E T K +V ++ A +
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
Query: 593 GGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTA---GQPLPGERLEIYVQSKMDEKNA 649
+ ++ E +E + + P ++ P P + L K EK
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
Query: 650 HIPSESIACKRDPEQAKEEPGHIPTQHV-----------EEAVNEVDNENTQQKDDESDA 698
+ S S + + + EE PT+ V ++A + + ++ +A
Sbjct: 318 PVES-SEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 699 PCSSLGLSSSGSGDAARAPKS-----VPRPKRLTSSTYNL--RHAHSLGSLDASK----- 746
P G + + S A KS PK+ L R A S S + S
Sbjct: 377 PSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEE 436
Query: 747 -------VTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQE 799
T K A+ +P + S D + D + +E+ K + +++ Q+
Sbjct: 437 KTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQK 496
Query: 800 LIAN-FNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLK 836
+ ++ +KG + + + +KLK
Sbjct: 497 VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLK 534
>gi|122937227 U2-associated SR140 protein [Homo sapiens]
Length = 1029
Score = 54.7 bits (130), Expect = 5e-07
Identities = 61/284 (21%), Positives = 110/284 (38%), Gaps = 39/284 (13%)
Query: 948 WAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRN--SHPPANLPTPASTRILRKYSN 1005
W F ++ + E E+ + + ED+ E+ + S+P T + KYS
Sbjct: 779 WELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESK---FSKYSE 835
Query: 1006 IRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKST 1065
+ + RA+ R I+ + M+ D L +P + P + Q
Sbjct: 836 MSEEKRAKLREIELKVMKFQDELESGKRPKK----------PGQSFQ------------- 872
Query: 1066 EGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAK 1125
+QV K + K K E D K+K SK+K TP K
Sbjct: 873 --------EQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDEC-TPTRK 923
Query: 1126 RPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPA 1185
R +S P ++S +VK P + +S R KE++ R S + ++K A
Sbjct: 924 ERKRRHSTSPSPSRSS-SGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKA 982
Query: 1186 KQKGAG-ESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKR 1228
K+ +G + R +++ +R ++R +++P S + K+
Sbjct: 983 KRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKK 1026
Score = 32.0 bits (71), Expect = 3.8
Identities = 44/195 (22%), Positives = 74/195 (37%), Gaps = 48/195 (24%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEI----LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKH 1114
P+K + TE K K ++SE L + E++ + + E S K G + + E +
Sbjct: 820 PIKEEMTES-KFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHY 878
Query: 1115 ADGATKTPAAK---RPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKE---NT 1168
D + K R RD+ + ++ K+ K K C P+RKE++ +T
Sbjct: 879 RDKLLQREKEKELERERERDKKDKEKLESRSKDKKEK-------DECTPTRKERKRRHST 931
Query: 1169 NKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKR 1228
+ PS+S SSG+ PS K+ S ++R
Sbjct: 932 SPSPSRS------------------------------SSGRRVKSPSPKSERSERSERSH 961
Query: 1229 KLKAKLDCSHSKRRR 1243
K ++ SH R
Sbjct: 962 KESSRSRSSHKDSPR 976
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 53.9 bits (128), Expect = 9e-07
Identities = 199/1025 (19%), Positives = 361/1025 (35%), Gaps = 140/1025 (13%)
Query: 267 EGGGDVSPRKE-PQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGST 325
+G G V P K P P K + + SS SEE++ SS A P ++ G
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESS--SEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 326 VSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPP-- 383
+ PT+S P PVA+ E + S++S + ++ + P
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 384 EIVSREESPQCSENQSSP------MGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL 437
+I + P+ + +S +G + P G A S V G +
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA------ 690
Query: 438 KESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGK 497
E S+ ++E+ SE E++ A +G+ + K L K SL + GK
Sbjct: 691 -EDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 498 KFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPK-----NPSAKRSK----- 547
P + Q DS S++ ++ + +S A ++ V K NP+A R+
Sbjct: 747 TGPTVTQVKAEKQ-EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 548 --------------KEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNER----------PS 583
K+ P P P + PSV + P
Sbjct: 806 ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
Query: 584 EKDAEQEGEGGGIITRQTLKNMLDK-EVKELRGEIFPSRDPITTAGQPLP---------- 632
E E E +TL + + ++R + P+++ P P
Sbjct: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 633 -GERLEIYVQSKMDEKNAHIPSESIACKR--------DPEQAKEEPGHIPTQHVEEAVNE 683
G++ + S+ + + P+ + + DP ++ P P Q +
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQA------Q 979
Query: 684 VDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLD 743
+ + + ES A SS S S D A + + R T H
Sbjct: 980 AASTPRKARASESTARSSS---SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Query: 744 ASKVTSEKEAAQVNPIMPKENGASESGD------PLDEDDVDTVVDEQPKFMEWCAEEEN 797
+ +S KE+++++ +E A++ PL + + + + + A +
Sbjct: 1037 MAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQP 1096
Query: 798 QELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRSRKCRSSLESQKC 857
+ + ++ +G R + K ++++ K+ + S S +S
Sbjct: 1097 SSGVDSAVGTLPATSPQSTSVQAKGTNKLR-KPKLPEVQQATKAPESSDDSEDSSDSSSG 1155
Query: 858 SPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGD--VPPVKHPLQKYAPSSL 915
S K ++ L T +R+ +V++ D V P + L Y L
Sbjct: 1156 SEEDGEGPQGAKSAHT----LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1211
Query: 916 YPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPD---QVEPEDGSDV-SPGPN 971
P++ QA + L P + L AK ++PD + +P+ + + SP
Sbjct: 1212 TPANSQASKATPKLDSSPSVSST--------LAAK--DDPDGKQEAKPQQAAGMLSPKTG 1261
Query: 972 SEDSIEEVKEDRNSHPPANLPTP-ASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAV 1030
+++ ++ P P AST L+ SNI L Q + +++ A V
Sbjct: 1262 GKEAASGTTPQKSRKPKKGAGNPQASTLALQ--SNITQCLLGQPWPLNEAQVQ---ASVV 1316
Query: 1031 ESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRK----GKQVSEILPKAEVQ 1086
+ + L+ + VD K S +G + RK G Q + P+++ +
Sbjct: 1317 K--------VLTELLEQERKKVVDT----TKESSRKGWESRKRKLSGDQPAARTPRSKKK 1364
Query: 1087 SKRKRTEGSSPPDSKNKGPTVKASKEKH--ADGATKTPAAKRPAARDRSSQPPKKTSLKE 1144
K EG S K T K K A G K K + P++ L++
Sbjct: 1365 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEE-ELQK 1423
Query: 1145 NKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRK 1204
+ + +S P S+KEK+ ++KR E K AK+ +S S QK +K
Sbjct: 1424 GMGTV--EGGDQSNPKSKKEKKKSDKRKKDKEKKEK-KKKAKKASTKDSESPSQKKKKKK 1480
Query: 1205 QSSGK 1209
+ + +
Sbjct: 1481 KKTAE 1485
Score = 43.9 bits (102), Expect = 0.001
Identities = 64/304 (21%), Positives = 115/304 (37%), Gaps = 27/304 (8%)
Query: 956 DQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRG-KLRAQQ 1014
D D +DV P+ + + + PA PA ++ ++G L +
Sbjct: 202 DTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAK 261
Query: 1015 RLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMK----G 1070
R K E+ ES+ + + + + + LQV A P K +G G
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 1071 RKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAAR 1130
+ G S+ + +E SS DS+ + P KA + A G T A
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESS--DSEEETPAAKALLQAKASGKTSQVGA------ 373
Query: 1131 DRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK---PAKQ 1187
+ P K S ++ P GK+ P K + + SQS + E+ ++ PA+
Sbjct: 374 ---ASAPAKESPRKGAAPAPP---GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQA 427
Query: 1188 KGAGE-----SSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRR 1242
K +G+ ++S P K + RK ++ + + +++ ++ + S S R
Sbjct: 428 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 1243 RLDA 1246
L A
Sbjct: 488 ALAA 491
Score = 40.0 bits (92), Expect = 0.014
Identities = 111/577 (19%), Positives = 187/577 (32%), Gaps = 100/577 (17%)
Query: 289 KPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLD 348
KP S SEE++ S P L + S V A +A SP P
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Query: 349 TEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQ-------CSENQSSP 401
T E S SE+ S +P + ++PQ E+
Sbjct: 394 TGPAVAKAQA---GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 450
Query: 402 MGLEPPMSLGKA----------EDNQSISAEVES----------GDTQELNVDPLLKESS 441
PP G A ED++S S E +S + L P +K +S
Sbjct: 451 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAS 510
Query: 442 TF---------TDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDK 492
T P + + + +GK E ED + D+ D + + +
Sbjct: 511 TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE-EDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 493 KKKG-----------------KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL-- 533
K G K P A + +S S++ + S+ + A +
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 534 -----EIKVPKNPSAKRSKKEGHPGGTTPKGL---LPDSFHTETLEDTEKPSV---NERP 582
+K+P+ + + P + P T T P+V +RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 583 S-------EKDAEQEGEGGGIITRQTLKNMLDKEVK----ELRGEIFPSRDPITTAGQPL 631
+ E D+E+E G + Q +VK ++G + P+ L
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV------L 743
Query: 632 PGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQ 691
PG+ Q K +++ SES + D E+A P + T V +
Sbjct: 744 PGKTGPTVTQVKAEKQE---DSESSEEESDSEEAAASPAQVKT--------SVKKTQAKA 792
Query: 692 KDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEK 751
+ AP + +S+ G A A P ++ N +++ L AS + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 752 EAAQVNPIM--PKENGASESGDPLDEDDVDTVVDEQP 786
A P+E+ S + E++ +T+ +P
Sbjct: 853 AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP 889
Score = 37.0 bits (84), Expect = 0.12
Identities = 63/309 (20%), Positives = 107/309 (34%), Gaps = 29/309 (9%)
Query: 961 EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPT-PASTRILRKYSNIRGKLRAQQRLIKN 1019
E+ P + S + +K P P PA+T + ++ K RA + ++
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARS 996
Query: 1020 EKMECPDALAVESKPS-----RKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGK 1074
E D + + R +V P P++A + G +S+ G+K +
Sbjct: 997 SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQE 1056
Query: 1075 ----QVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAAR 1130
QVS+ P A + + + + S+ + P + D A T PA
Sbjct: 1057 GPATQVSKKNP-ASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT----LPATS 1111
Query: 1131 DRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGA 1190
+S+ K + K K K+P+ P S + E+++ S S + E P K A
Sbjct: 1112 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS--DSSSGSEEDGEGPQGAKSA 1169
Query: 1191 GESSSRPQKATNRKQSSGKTRARPSTKTPESS------------AAQRKRKLKAKLDCSH 1238
P + + + + P S A + K KLD S
Sbjct: 1170 HTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSP 1229
Query: 1239 SKRRRLDAK 1247
S L AK
Sbjct: 1230 SVSSTLAAK 1238
Score = 31.6 bits (70), Expect = 4.9
Identities = 46/197 (23%), Positives = 77/197 (39%), Gaps = 15/197 (7%)
Query: 1046 SPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKA-EVQSKRKRTEGSSPPDSKNKG 1104
SP+ + + A+ V EG G + A + S + T SS
Sbjct: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGK 215
Query: 1105 PTVKASKEKHADGATKTPAAKRPA-----ARDRSSQPPKKTSLKENKVKIPKKSAGKSCP 1159
P+VK ++ K + +TK A++ A D + Q + K P++ + S
Sbjct: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
Query: 1160 PSRKEKENTNKRPSQSIASETL------TKPAK-QKGAGESSSRPQK--ATNRKQSSGKT 1210
S E+E SQ ASE + + PAK G G + + P K A + +GK
Sbjct: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
Query: 1211 RARPSTKTPESSAAQRK 1227
+ + ESS ++ +
Sbjct: 336 EEDSESSSEESSDSEEE 352
Score = 30.8 bits (68), Expect = 8.4
Identities = 63/305 (20%), Positives = 96/305 (31%), Gaps = 48/305 (15%)
Query: 935 ATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPAN---- 990
A P K + K A RE Q E+ P + + R + PA
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448
Query: 991 ---LPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSP 1047
P P GK R E +ALA + K + +P
Sbjct: 449 KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP---- 504
Query: 1048 KLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTV 1107
VKP ST GM G GK + P + G DS++
Sbjct: 505 -----------QVKPASTMGM-GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES----- 547
Query: 1108 KASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKEN 1167
+S+E + P A PA +++S + + K P + AG + EK
Sbjct: 548 -SSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 605
Query: 1168 TNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRK 1227
N S+ + + +S P T +A+P+ K P++ A +K
Sbjct: 606 DNSESSE-----------ESSDSADSEEAPAAMT-------AAQAKPALKIPQTKACPKK 647
Query: 1228 RKLKA 1232
A
Sbjct: 648 TNTTA 652
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 51.6 bits (122), Expect = 5e-06
Identities = 91/490 (18%), Positives = 171/490 (34%), Gaps = 37/490 (7%)
Query: 291 NLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTE 350
N S S S ++ +S + + D + + S+ +++ S + + D+
Sbjct: 559 NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS-------DSS 611
Query: 351 EMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSL 410
+ S D S S S S D S+ S S S + S+
Sbjct: 612 DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS 671
Query: 411 GKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDV 470
+ D+ S S S D+ + + ESS +D + S++ +S + + + +
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN- 730
Query: 471 KCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSS-SADRCLRNQSSDS- 528
D+ D+S S + ++SD S SDSS S+D + SSDS
Sbjct: 731 ----SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786
Query: 529 -SSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDA 587
SS + N S + + + +S + D+ S + S+
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846
Query: 588 EQEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEK 647
+G R N D S D ++ + E S +
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSS---------DSSDSSNSSDSSDSSDSNESSNSSDSSDS 897
Query: 648 NAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSS 707
+ S+S D + + + E+ N DN N+ + SD+ SS +S
Sbjct: 898 SNSSDSDS----SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 708 SGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGAS 767
S S +++ + S +S + + + S S D+S + +++ + + +S
Sbjct: 954 SDSSNSSDSSNSSD-----SSDSNSSDSSDSSNSSDSSDSSDSSDSSDSS----DSSNSS 1004
Query: 768 ESGDPLDEDD 777
+S D D D
Sbjct: 1005 DSSDSSDSSD 1014
Score = 50.1 bits (118), Expect = 1e-05
Identities = 80/487 (16%), Positives = 164/487 (33%), Gaps = 19/487 (3%)
Query: 291 NLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTE 350
N S S S +++ SS D + + +S S ++ D+
Sbjct: 751 NSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS 810
Query: 351 EMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSL 410
+ S D S++S + S D + S S + S S N+S
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD- 869
Query: 411 GKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDV 470
+ D+ + S +S D+ E + +SS +D + S++ S +
Sbjct: 870 --SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 471 KCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSS 530
++ D+S S + +SD S SDS+S+D + SSDSS
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987
Query: 531 ACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQE 590
+ + S+ S + S +++ ++ + ++ D+
Sbjct: 988 SS-----DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042
Query: 591 GEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAH 650
+ N D + S D ++ + + S + +
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Query: 651 IPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGS 710
S + D + + + ++ + D+ N+ D S++ SS SS S
Sbjct: 1103 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS 1162
Query: 711 GDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESG 770
D++ + S + S+ + + S S D+S + +++ + + +S+S
Sbjct: 1163 SDSSDSSDS-------SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS----DSSDSSDSS 1211
Query: 771 DPLDEDD 777
D D D
Sbjct: 1212 DSSDSSD 1218
Score = 47.4 bits (111), Expect = 9e-05
Identities = 67/373 (17%), Positives = 135/373 (36%), Gaps = 44/373 (11%)
Query: 409 SLGKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDG 468
S G + + + +SG + + D +SS +D + S +S + + D
Sbjct: 526 SNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585
Query: 469 DVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDS 528
D S+ D+ D+S S + ++SD S S+S S+D ++ SSDS
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645
Query: 529 SSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAE 588
+S+ + S+ S S +++ + ++ S ++ + D+
Sbjct: 646 NSSDSSDNSDSSDSSNSSN---------------SSDSSDSSDSSDSSSSSDSSNSSDSS 690
Query: 589 QEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKN 648
+ + D + + S D + S D N
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSD-------SSDSSNSN-------------SSDSDSSN 730
Query: 649 AHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSS 708
+ S+S + D + + + ++ N D+ ++ D SD+ SS SS
Sbjct: 731 SSDSSDS-SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 709 GSGDAARAPKSVPRPKRLTSS-TYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGAS 767
S D++ + S SS + + + S S D+S + +++ + +S
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSS-------NSSDSS 842
Query: 768 ESGDPLDEDDVDT 780
+S D D D D+
Sbjct: 843 DSSDSSDGSDSDS 855
Score = 45.1 bits (105), Expect = 4e-04
Identities = 70/416 (16%), Positives = 143/416 (34%), Gaps = 13/416 (3%)
Query: 363 STESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAE 422
S++S S D S S S + S + ++SS + D+ + ++
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724
Query: 423 VESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTS 482
+ D S+ + ++ + ++ S+++ + D D+ D+S
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS----DSSDSSDSS 780
Query: 483 IDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPS 542
S + +SD S SDSS + + SSDSS++ + N S
Sbjct: 781 NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS-DSSDSSNSS 839
Query: 543 AKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTL 602
+ G + DS ++ D+ S + S+ E + +
Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899
Query: 603 KNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDP 662
+ D + S + ++ + + D N+ S+S
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN-----SNSSDSSNSSDSSDSSDSSNSS 954
Query: 663 EQA-KEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVP 721
+ + + + + + D+ N+ D SD+ SS SS S D++ + S
Sbjct: 955 DSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014
Query: 722 RPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDD 777
SS + ++S S D+S + +++ + N +S+S D D D
Sbjct: 1015 SSNSSDSSN-SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN-SSDSSDSSDSSD 1068
Score = 44.3 bits (103), Expect = 7e-04
Identities = 71/408 (17%), Positives = 139/408 (34%), Gaps = 26/408 (6%)
Query: 387 SREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDE 446
S + S + SS S ++ + S S++ D+ + + +SS +D
Sbjct: 554 SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS 613
Query: 447 NPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRC 506
+ S ++ S++ K E + D S+ D+ D++ +N D +SD
Sbjct: 614 SDS-SDSSDSKSDSSKSESDSSDSD--SKSDSSDSNSSDSSDNSDSSDSSNS-SNSSDSS 669
Query: 507 LRSQLSDSSSA-DRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSF 565
S SDSSS+ D + SSDSS + + + + S + DS
Sbjct: 670 DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729
Query: 566 HTETLEDTEKPSVNERPSE----------------KDAEQEGEGGGIITRQTLKNMLDKE 609
++ D+ S + S+ D+ + + D
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 610 VKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEP 669
+ S D ++ + + + D N+ S+S + +
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 670 GHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSS 729
G ++ N D+ N+ D SD+ SS SS S +++ + S S
Sbjct: 850 G-----SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD 904
Query: 730 TYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDD 777
+ + ++ S +SE + N + +S+S D D +
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952
Score = 44.3 bits (103), Expect = 7e-04
Identities = 70/426 (16%), Positives = 141/426 (33%), Gaps = 22/426 (5%)
Query: 363 STESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAE 422
S S S SE S S + +S + + S + D+ S
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Query: 423 VESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTS 482
S D+ + + +SS +D + S + + + D S+ S
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 483 IDSLEENLDKKKKGKKFPEASDRCLRSQLSDS---------SSADRCLRNQSSDSSSACL 533
DS + + +SD S SDS S +D R+ SS+SS +
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869
Query: 534 EIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEG 593
+ + S ++ +S +++ + + ++ + D+ +
Sbjct: 870 SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929
Query: 594 GGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPS 653
N D + S D ++ + + D N+ S
Sbjct: 930 SDNSNSSDSSNSSDSSDS---SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986
Query: 654 ES--IACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSG 711
+S + D + + ++ N D+ N+ + SD+ SS SS S
Sbjct: 987 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSS 1046
Query: 712 DAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGD 771
D++ + S ++S+ + + S S D+S + ++++ + N +S+S D
Sbjct: 1047 DSSDSSDS-------SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN-SSDSSD 1098
Query: 772 PLDEDD 777
D D
Sbjct: 1099 SSDSSD 1104
Score = 44.3 bits (103), Expect = 7e-04
Identities = 75/463 (16%), Positives = 158/463 (34%), Gaps = 19/463 (4%)
Query: 318 DLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVIS 377
D + ++ + +S S+ + D+ + S D + S+ S S +
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN--DSSNSSDSSDSSNSSD 802
Query: 378 RPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL 437
+S S + S S N S + D+ S + D+ N
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS 862
Query: 438 K--ESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKK 495
+SS +D + S + + D S+ D+ D+S S +
Sbjct: 863 NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSD 922
Query: 496 GKKFPEASDRCLRSQLSDSS-SADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGG 554
+ +SD S S+SS S+D + SSDSS++ + S + +
Sbjct: 923 SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS-------SDSSNSSDSSDSNSSD 975
Query: 555 TTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVKELR 614
++ DS +++ + ++ ++ + D+ + N D
Sbjct: 976 SSDSSNSSDS--SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDS 1033
Query: 615 GEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPT 674
+ S D ++ + S + + S + D ++ + +
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093
Query: 675 QHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLR 734
++ + D+ ++ D SD+ SS SS S D++ + S + S+ +
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS----SNSSDSSDSSE 1149
Query: 735 HAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDD 777
+ S S D+S + +++ + N +S+S D D D
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSN-SSDSSDSSDSSD 1191
Score = 38.1 bits (87), Expect = 0.053
Identities = 64/351 (18%), Positives = 119/351 (33%), Gaps = 12/351 (3%)
Query: 253 DNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPA 312
D+ + +S D S + + + N S S S +++ SS
Sbjct: 943 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Query: 313 HLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVS 372
D + + ++ +S S ++ D+ + S D S++S + S
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSS--DSSDSSNSSDS 1060
Query: 373 EDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMS-LGKAEDNQSISAEVESGDTQEL 431
D S S + S + SS S + D+ S +S D+ +
Sbjct: 1061 SDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1120
Query: 432 NVDPLLKESSTFTDE----NPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLE 487
+ +SS +D N S++ +S + D+ D+S S
Sbjct: 1121 SNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1180
Query: 488 ENLDKKKKGKKFPEASDRCLRSQLSDSS----SADRCLRNQSSDSSSACLEIKVPKNPSA 543
+ ++SD S SDSS S+D + SSDSS + + + +
Sbjct: 1181 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDS 1240
Query: 544 KRSKKEGHPGGTTPKGLLPDSFHTETLE-DTEKPSVNERPSEKDAEQEGEG 593
S + ++ DS E D++ S N + D++ + EG
Sbjct: 1241 SDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEG 1291
Score = 31.6 bits (70), Expect = 4.9
Identities = 45/224 (20%), Positives = 78/224 (34%), Gaps = 8/224 (3%)
Query: 293 SSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEM 352
S S S +++ SS D + + + +S S+ + D+ +
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1138
Query: 353 SVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMS-LG 411
S D S+ES S D S S + S + + SS S
Sbjct: 1139 SNSSDSS--DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1196
Query: 412 KAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVK 471
+ D+ S +S D+ + + +SS +D N S + + D
Sbjct: 1197 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSD-- 1254
Query: 472 CLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSS 515
D+ D++ DS +E+ + K G SD S+ SDS+
Sbjct: 1255 ---SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 51.6 bits (122), Expect = 5e-06
Identities = 62/273 (22%), Positives = 107/273 (39%), Gaps = 31/273 (11%)
Query: 973 EDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVES 1032
+ +++ + R S PA P P+ + + ++ ++ + K K+E + + V+
Sbjct: 532 QTKLKQRADSRESLKPAAKPLPSKS-VRKESKEETPEVTKVNHVEKPPKVESKEKVMVKK 590
Query: 1033 -KPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKR 1091
KP + P ++ K + + PVK + E KQ +++ PKA + K+
Sbjct: 591 DKPIKTET--KPSVTEK-EVPSKEEPSPVKAEVAE-------KQATDVKPKAAKEKTVKK 640
Query: 1092 TEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPK 1151
P D K + K K D KTP K + + K +K+ + K PK
Sbjct: 641 ETKVKPEDKKEEKEKPKKEVAKKED---KTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
Query: 1152 KSAGKSCPP----------SRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKAT 1201
K K PP +KE + K P + I + L K AK+ S ++ A
Sbjct: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI--KKLPKDAKKSSTPLSEAKKPAAL 755
Query: 1202 NRKQSSGKTRARPSTKTPESSAAQRKRKLKAKL 1234
K + S K +A + K K K K+
Sbjct: 756 KPK----VPKKEESVKKDSVAAGKPKEKGKIKV 784
Score = 48.1 bits (113), Expect = 5e-05
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 23/183 (12%)
Query: 1071 RKGKQVSEILPKAEVQSKRKRTEGSSPP--------------DSKNKGPTVKASKE---K 1113
++G+Q E P + +S +T+ PP DS+++ T+ K K
Sbjct: 2137 QQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYK 2196
Query: 1114 HADGATKTPAAKRPAAR--DRSSQPPKKTSLKENKVKIPKKSAG---KSCPPSRKEKENT 1168
H D + P+ R D S P+ ++++N K KK K+ P K K ++
Sbjct: 2197 HMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSS 2256
Query: 1169 NKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKR 1228
+ S S+ L K G ESS + + + K+ +A T TPE AA+ +
Sbjct: 2257 PVKKSDG-KSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEE 2315
Query: 1229 KLK 1231
K K
Sbjct: 2316 KDK 2318
Score = 42.0 bits (97), Expect = 0.004
Identities = 67/331 (20%), Positives = 120/331 (36%), Gaps = 83/331 (25%)
Query: 904 KHPLQKYAPSSLYPSSLQ-------AERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPD 956
KHP + +PS + P+ L+ E +K L + GA P + + D
Sbjct: 2091 KHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGR-------QCD 2143
Query: 957 QVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRL 1016
+ P S+ +P D E +E + AN+ + + + +
Sbjct: 2144 ETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETI-----------PTDKT 2192
Query: 1017 IKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQV 1076
+ + M+ P A + PS + ++ VD + ++ + +K
Sbjct: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVS---------MVDPEALAIEQNLGKALK------- 2236
Query: 1077 SEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQP 1136
++ K + + +T+ SSP K +DG +K AA
Sbjct: 2237 KDLKEKTKTKKPGTKTKSSSPV--------------KKSDGKSKPLAAS----------- 2271
Query: 1137 PKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSR 1196
PK LKE+ K+ + + S K+KE+ K A++ T P + GE +
Sbjct: 2272 PKPAGLKESSDKVSRVA-------SPKKKESVEK------AAKPTTTPEVKAARGEEKDK 2318
Query: 1197 PQK----ATNRKQSSGKTRARPSTKTPESSA 1223
K A+ K + T +TKT +SSA
Sbjct: 2319 ETKNAANASASKSAKTATAGPGTTKTTKSSA 2349
Score = 35.4 bits (80), Expect = 0.34
Identities = 91/430 (21%), Positives = 146/430 (33%), Gaps = 71/430 (16%)
Query: 366 SFSGGVSEDVISRPHSPPEIVSREESPQCS-ENQSSPMGLEPPMSLGKAEDNQSISAEVE 424
S S + D +R P E + Q + E S P ++ + +++ + E E
Sbjct: 1094 SESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETE 1153
Query: 425 SGDTQELNVDPLLKESSTFTDE--NPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTS 482
S + +N+ ESS ++ E P++ K + DG KD Y+ S
Sbjct: 1154 SPSQEFVNITKY--ESSLYSQEYSKPADVTPLNGFSEGSKTDATDG-------KD-YNAS 1203
Query: 483 IDSLEENLDKKKKGKKFPEASDRCLRSQLSDS--SSADRCLRNQSSDSSSACLEIKVPKN 540
++ ++ D+ RS L D+ S DS SA KV +
Sbjct: 1204 ASTISPPSSMEE---------DKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPS 1254
Query: 541 PSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQ 600
S S P TP G +F E P + QE + +
Sbjct: 1255 KSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQE------VVEE 1308
Query: 601 TLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIA--- 657
+ DK ++ + PS+ +AG Y QS DEK++H+P+E I
Sbjct: 1309 HCASPEDKTLEV----VSPSQSVTGSAGHTP-------YYQSPTDEKSSHLPTEVIEKPP 1357
Query: 658 ----------CKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSS-LGLS 706
K + E+A P P E + +V + S++ S L
Sbjct: 1358 AVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSAD 1417
Query: 707 SSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGA 766
SG A +P K+ GS D +V+ E + K+ G
Sbjct: 1418 DKASGRGAESPFEEKSGKQ--------------GSPD--QVSPVSEMTSTSLYQDKQEGK 1461
Query: 767 SESGDPLDED 776
S P+ ED
Sbjct: 1462 STDFAPIKED 1471
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 50.8 bits (120), Expect = 8e-06
Identities = 66/316 (20%), Positives = 121/316 (38%), Gaps = 54/316 (17%)
Query: 953 ENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRK-YSNIRGKLR 1011
E+ D E D ++ P + I + K ++ P + T + + K +R K +
Sbjct: 120 EDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEK 179
Query: 1012 AQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGR 1071
+++ EK+E + KP K++ K A + + K+ + +KG
Sbjct: 180 PEKKATHKEKIE------KKEKPETKTLA----KEQKKAKTAEKS----EEKTKKEVKGG 225
Query: 1072 KGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHAD--------------- 1116
K ++V + K + K +P K K KA+ KH
Sbjct: 226 KQEKVKQTAAKVKEVQK-------TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFV 278
Query: 1117 -GATK---TPAAKRPAARDRSSQP-PKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKR 1171
G K +PA P +++S+P P +L+E + + K + +KEKE+ K+
Sbjct: 279 HGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKK 338
Query: 1172 PSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLK 1231
+ A + K P KA+ KQ + K A+ + K E +K K
Sbjct: 339 SEKETAIDVEKK------------EPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKP 386
Query: 1232 AKLDCSHSKRRRLDAK 1247
A+++ K++ K
Sbjct: 387 AEVEQPKGKKQEKKEK 402
Score = 43.9 bits (102), Expect = 0.001
Identities = 56/233 (24%), Positives = 90/233 (38%), Gaps = 29/233 (12%)
Query: 989 ANLPTPASTRILRKYSN-------IRGKLRAQQRLIKNEKMECPDALAVESKPSRKS--- 1038
A+ PTPAS + K + + + +++ +K E A+ VE K K+
Sbjct: 299 ASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASET 358
Query: 1039 ----VCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEG 1094
V I + K + + KP E KG+K ++ + + A K + E
Sbjct: 359 KQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA----KSPKKEH 414
Query: 1095 SSPPDSKNKGPTVKASKE-------KHADGATKTPAAKRPAARDRSSQPPKKTSLKENKV 1147
S P D + K T +A +E K G + K R + K +S+ ++K
Sbjct: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKE 474
Query: 1148 KIPKKSAGKSCPPSRKEKENTNKRPSQ--SIASETLTKPAKQKGAGESSSRPQ 1198
P K + P S KEKE K+ + E KP + +G E PQ
Sbjct: 475 --PIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQ 525
Score = 38.5 bits (88), Expect = 0.040
Identities = 49/252 (19%), Positives = 99/252 (39%), Gaps = 18/252 (7%)
Query: 440 SSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKF 499
+S +E E +++E + E D+K SEK+T +ID ++KK+ GK
Sbjct: 305 ASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET---AID-----VEKKEPGKAS 356
Query: 500 PEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKG 559
+++ ++A + + + S + E++ PK ++ +K P + K
Sbjct: 357 ETKQGTV---KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
Query: 560 -LLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVKELRGEIF 618
+P + + K + +K + E T +T++ + KE I
Sbjct: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEK---TTKTVEQEIRKEKSGKTSSIL 470
Query: 619 PSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVE 678
++PI + +P E ++K DEK + E K P Q + + P ++
Sbjct: 471 KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKE---VKPKPPQLQGKKEEKPEPQIK 527
Query: 679 EAVNEVDNENTQ 690
+ +E Q
Sbjct: 528 KEAKPAISEKVQ 539
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 50.4 bits (119), Expect = 1e-05
Identities = 61/288 (21%), Positives = 112/288 (38%), Gaps = 46/288 (15%)
Query: 949 AKFRENPDQVE---PEDGSDVSPGPNSEDS------IEEVKEDRNSHPPANLPTPASTRI 999
A+ RE +Q E EDG+ VSP ++ + EE K PT +
Sbjct: 13 AEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESG--- 69
Query: 1000 LRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFP 1059
K EK D ++ E + N L K+ Q +A G
Sbjct: 70 ------------------KQEKAPAEDGMSAELQGEA-----NGLDEVKVESQREAGG-- 104
Query: 1060 VKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGAT 1119
K + +K G++ + E+ +++ T+ S P +++ K T+ + K+K +
Sbjct: 105 -KEDAEAELKKEDGEKEETTVGSQEMTGRKEETK-SEPKEAEEKESTLASEKQKAEEKEA 162
Query: 1120 KTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAG--KSCPPSRKEKENTNKRPSQS-- 1175
K + ++ A DR PK T +E+ ++ G K C KEK + ++S
Sbjct: 163 KPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQK 222
Query: 1176 --IASETLTKPAKQKGAGESS-SRPQKATNRKQSSGKTRARPSTKTPE 1220
+ E +P + G E+ ++A ++++ A P + + E
Sbjct: 223 AVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEE 270
Score = 40.0 bits (92), Expect = 0.014
Identities = 55/232 (23%), Positives = 83/232 (35%), Gaps = 26/232 (11%)
Query: 382 PPEIVSREESP----QCSENQSSPMGL-----EPPMSLGKAEDNQSISAEVESGDTQELN 432
P E +E++P +E Q GL E G ED ++ + E G+ +E
Sbjct: 65 PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEA-ELKKEDGEKEETT 123
Query: 433 VDPL-LKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLD 491
V + T P E EE E+ K + E+ + K S + D E
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKAT 183
Query: 492 KKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKV---PKNPSAKRSKK 548
+++ K + R + S ++S A +E + PK P K K
Sbjct: 184 VEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAK 243
Query: 549 EGHPGGTTPKGLLPDSFHTETLEDTE--KPSVNERPSEKDAEQEGEGG-GII 597
G K E ED E +P E+D E+E EGG G+I
Sbjct: 244 HGAKEEADAK---------EEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVI 286
Score = 35.4 bits (80), Expect = 0.34
Identities = 46/213 (21%), Positives = 74/213 (34%), Gaps = 22/213 (10%)
Query: 1020 EKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEI 1079
EKME + E + NP MS G P E KG GK ++E
Sbjct: 17 EKMEQKEGKLSEDGTTVSPAADNPEMS--------GGGAPA-----EETKGTAGKAINEG 63
Query: 1080 LP-KAEVQSKRKRTEGSSPP--DSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQP 1136
P ++ Q K +G S N VK ++ A G A +
Sbjct: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELK------KEDG 117
Query: 1137 PKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSR 1196
K+ + ++ +K KS P +EKE+T Q + + QK +
Sbjct: 118 EKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK 177
Query: 1197 PQKATNRKQSSGKTRARPSTKTPESSAAQRKRK 1229
P+ ++ KT ++ T + + + K K
Sbjct: 178 PEPKATVEEEDAKTASQEETGQRKECSTEPKEK 210
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 50.1 bits (118), Expect = 1e-05
Identities = 99/497 (19%), Positives = 181/497 (36%), Gaps = 74/497 (14%)
Query: 247 VQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKI-KPNLSSSPRSEETTASS 305
++ P + +P E E GD + +PE + + + P SE+
Sbjct: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894
Query: 306 LVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTE 365
W + PE + E AP A + PE V L+TE P+ + E
Sbjct: 1895 AEWEVQ---PESEGAE------APEAEKEAQPETES--VEALETEGEDEPES-EGAEAQE 1942
Query: 366 SFSGGVSEDVISRPHSPPEIVSREES-----PQCSENQSSPMGLEPPMSLGKAE-DNQSI 419
+ + ++P S E++ +E+ P+ + ++ + +E + G+A+ +++ +
Sbjct: 1943 AEEAAQEAEGQTQPES--EVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDV 2000
Query: 420 SAEVESGDTQELNVDPLLKESSTFTDENPSETEES-EAAGGIGKLEGE-----DGDVKCL 473
A G+ QE + ES + SE EE+ E G K EG+ DG
Sbjct: 2001 EAPEAEGEMQEAE-EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
Query: 474 SEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL 533
+E++ + E ++ +G+ PE+ D + ++ + ++ +
Sbjct: 2060 AEEEAQEA------EGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKA 2113
Query: 534 E-IKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLE-----DTEKPSVNERPSEKDA 587
E I+ P+ + + EG P+S E + E + + +E++A
Sbjct: 2114 EGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
Query: 588 EQEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEK 647
+ E EG E E GE P + I ++ E
Sbjct: 2174 QPELEG--------------VEAPEAEGEAQPESEGI----------------EAPEAEG 2203
Query: 648 NAHIPSESIACKRDPEQAKEEPGHIPTQHVE-EAVNEVDNENTQQKDDESDAPCSSLGLS 706
A E + E+A+ EP + T E EA E + E +K +P SLG
Sbjct: 2204 EAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEK---KGSPQVSLGDG 2260
Query: 707 SSGSGDAARAPKSVPRP 723
S + +P RP
Sbjct: 2261 QSEEASESSSPVPEDRP 2277
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 50.1 bits (118), Expect = 1e-05
Identities = 74/341 (21%), Positives = 123/341 (36%), Gaps = 56/341 (16%)
Query: 912 PSSLYPSSLQAER---LKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSP 968
PSS + ++ + R +KK K P T K +K S
Sbjct: 597 PSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYK--------------------STSKS 636
Query: 969 GPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDAL 1028
S + IE +S +LP + T KY + + +K +E D+
Sbjct: 637 SQKSREIIETDTSSSDSDESESLPPSSQTP---KYPE------SNRTPVKPSSVEEEDSF 687
Query: 1029 AVES--KPSRKSVCINPLMSPK----LALQVDAD---GFPVKP-KSTEGMKGRKG----- 1073
+ P + ++PL P L +++D + P KP K TE KG K
Sbjct: 688 FRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEK 747
Query: 1074 ------KQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRP 1127
KQ SE K + KRK S++K P + ++ ++K+
Sbjct: 748 HTREAQKQASE---KVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQS 804
Query: 1128 AARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQ 1187
AA+++ P + K S ++ S K ++N S +S+ + +KQ
Sbjct: 805 AAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQ 864
Query: 1188 KGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKR 1228
K +S K K S + PS T +SS +R +
Sbjct: 865 KKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTK 905
Score = 36.6 bits (83), Expect = 0.15
Identities = 160/806 (19%), Positives = 286/806 (35%), Gaps = 107/806 (13%)
Query: 103 KGQF--DHSKDGWLGPGPMPAVHKAANGHSRTKMISTSIKTARKSKRASGLRINDYDNQC 160
KGQ +HSK PG AV + HSR+ K ++SK N +D+
Sbjct: 166 KGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDAN-WDSPS 224
Query: 161 DVVYISQPITECHFENQKSILSSRKTARKSTRGYFFNGDCCELPTVRTLARNLHSQEKAS 220
V + S + F S++S + + Y VR + + K S
Sbjct: 225 RVPFSSGQHSTQSF--PPSLMSKSNSMLQKPTAY-----------VRPMDGQESMEPKLS 271
Query: 221 CSALASEAVFTPKQTLTIPAPRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQE 280
+S++ L + H +++P + S +++ +E +++ P
Sbjct: 272 SEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPL 331
Query: 281 PEV-CPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEH 339
+ P K +P+ P E ++ + P + T++G S
Sbjct: 332 TAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSK------------TSNGHQSKSM 379
Query: 340 NQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQS 399
+ + L +E+ QDC S G SE S +S SR++S S ++S
Sbjct: 380 LKDDLKLSSSEDSDGEQDCD-KTMPRSTPGSNSEP--SHHNSEGADNSRDDSSSHSGSES 436
Query: 400 SP-MGLEPPMSLGKAEDN---QSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESE 455
S E S +E N QS S E E T + +D L + NP + S
Sbjct: 437 SSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNK------VNPHKV--SP 488
Query: 456 AAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSS 515
A+ + G K E+ T ++ D+ K+ P + + Q S
Sbjct: 489 ASSVDSNIPSSQGYKKEGREQGTGNSYTDT----SGPKETSSATPGRDSKTI--QKGSES 542
Query: 516 SADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGG-----TTPKGL---LPDSFHT 567
R SDS++ + + A+++ E GG TP L +P S H
Sbjct: 543 GRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHK 602
Query: 568 ETLEDTEKPSVNE------RP-SEKDAEQEGEGGGIITRQTLKNMLDKEVKELRGEIFPS 620
+ + KP++ + RP +EK + +R+ ++ + + PS
Sbjct: 603 AATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPS 662
Query: 621 ----------RDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSES------IACKRDPEQ 664
R P+ + + S M+EK P + K D
Sbjct: 663 SQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNL 722
Query: 665 AKEEPGHIPTQHVEEAVNE---VDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVP 721
PG P + E E V ++T++ ++ S+ G + D RA +S
Sbjct: 723 LTRIPGK-PYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES-K 780
Query: 722 RPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTV 781
+PK T + H S +++ +S++ AA+ ++P G S DP
Sbjct: 781 KPK--TEDKNSAGHKPS-----SNRESSKQSAAKEKDLLPSPAGPVPSKDP--------- 824
Query: 782 VDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKS 841
E ++ + + +N N + K K+ + + + S ++KE K+
Sbjct: 825 KTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKE--KA 882
Query: 842 KKRSRKCRSS---LESQKCSPVQMLF 864
S C S L+S K +++F
Sbjct: 883 PSSSSNCPPSAPTLDSSKPRRTKLVF 908
>gi|239745501 PREDICTED: similar to acyl-CoA synthetase medium-chain
family member 2 [Homo sapiens]
Length = 1122
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/216 (23%), Positives = 84/216 (38%), Gaps = 32/216 (14%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEILPKA------EVQSKRKRTEGSSPP--DSKNKGPTVKA- 1109
P+ P + + +K +Q++ + P A +++ +R G PP D K P+ +
Sbjct: 891 PLPPSADDNLKTPSKRQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQL 950
Query: 1110 -----SKEKHADGATKTPAA--------------KRPAARDRSSQPPKKTSLKENKVKIP 1150
S AD KTPA K P+ R + PP + ++ +K P
Sbjct: 951 TPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPTSADDNIKTP 1010
Query: 1151 KKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNR---KQSS 1207
+ PPS + T +Q +E KP +Q+ A E P+ R + S
Sbjct: 1011 AERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQR-AAEMEPPPEPKRRRVGDVEPS 1069
Query: 1208 GKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRR 1243
K + R + SS ++R++ KRRR
Sbjct: 1070 RKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRR 1105
Score = 34.3 bits (77), Expect = 0.76
Identities = 35/178 (19%), Positives = 63/178 (35%), Gaps = 28/178 (15%)
Query: 1019 NEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSE 1078
++ ++ P + P P L + + P+ P + + +K +Q++
Sbjct: 298 DDNLKTPPECLLTPLPPSAPPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTP 357
Query: 1079 ILPKA------EVQSKRKRTEGSSPP--DSKNKGPTVKA------SKEKHADGATKTPAA 1124
+ P A +++ +R G PP D K P+ + S AD KTPA
Sbjct: 358 LPPSAPPSADDNIKTTAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAE 417
Query: 1125 --------------KRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENT 1168
K P+ R + PP ++ +K P + PPS + T
Sbjct: 418 HLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKT 475
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 77/210 (36%), Gaps = 44/210 (20%)
Query: 970 PNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALA 1029
P+++D+++ E + + P + P A I +RG L P A
Sbjct: 341 PSADDNLKTPSERQLTPLPPSAPPSADDNIKTTAERLRGPLP-------------PSADD 387
Query: 1030 VESKPSRKSVCINPLMSPKLA---LQVDADGF--PVKPKSTEGMKGRKGKQVSEILPKA- 1083
PS + + P +P A ++ A+ P+ P + + +K +Q++ + P A
Sbjct: 388 NLKTPSERQLTPLPPSAPPSADDNIKTPAEHLRGPLPPSADDNLKTPSERQLTPLPPSAP 447
Query: 1084 -----EVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPK 1138
+++ +R G PP AD KTP+ R + PP
Sbjct: 448 PSADDNIKTPAERLRGPLPPS---------------ADDNLKTPSE-----RQLTPLPPS 487
Query: 1139 KTSLKENKVKIPKKSAGKSCPPSRKEKENT 1168
++ +K P + PPS + T
Sbjct: 488 APPSADDNIKTPAEHLRGPLPPSADDNLKT 517
>gi|209529739 hypothetical protein LOC100132247 [Homo sapiens]
Length = 1133
Score = 48.9 bits (115), Expect = 3e-05
Identities = 50/216 (23%), Positives = 83/216 (38%), Gaps = 32/216 (14%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEILPKA------EVQSKRKRTEGSSPP--DSKNKGPTVKA- 1109
P+ P + + +K +Q++ + P A +++ +R G PP D K P+ +
Sbjct: 873 PLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQL 932
Query: 1110 -----SKEKHADGATKTPAA--------------KRPAARDRSSQPPKKTSLKENKVKIP 1150
S AD KTPA K P+ R + PP ++ +K P
Sbjct: 933 TPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTP 992
Query: 1151 KKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNR---KQSS 1207
+ PPS + T +Q +E KP +Q+ A E P+ R + S
Sbjct: 993 AERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQR-AAEMEPPPEPKRRRVGDVEPS 1051
Query: 1208 GKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRR 1243
K + R + SS ++R++ KRRR
Sbjct: 1052 RKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRR 1087
Score = 33.9 bits (76), Expect = 1.00
Identities = 31/138 (22%), Positives = 52/138 (37%), Gaps = 28/138 (20%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEILPKA------EVQSKRKRTEGSSPP--DSKNKGPTVKA- 1109
P+ P + + +K +Q++ + P A +++ +R G PP D K P+ +
Sbjct: 376 PLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQL 435
Query: 1110 -----SKEKHADGATKTPAA--------------KRPAARDRSSQPPKKTSLKENKVKIP 1150
S AD KTPA K P+ R + PP ++ +K P
Sbjct: 436 TPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTP 495
Query: 1151 KKSAGKSCPPSRKEKENT 1168
+ PPS + T
Sbjct: 496 AERLRGPLPPSADDNLKT 513
>gi|157074225 nuclear pore complex interacting protein-like 3 [Homo
sapiens]
Length = 678
Score = 48.9 bits (115), Expect = 3e-05
Identities = 50/216 (23%), Positives = 83/216 (38%), Gaps = 32/216 (14%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEILPKA------EVQSKRKRTEGSSPP--DSKNKGPTVKA- 1109
P+ P + + +K +Q++ + P A +++ +R G PP D K P+ +
Sbjct: 418 PLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQL 477
Query: 1110 -----SKEKHADGATKTPAA--------------KRPAARDRSSQPPKKTSLKENKVKIP 1150
S AD KTPA K P+ R + PP ++ +K P
Sbjct: 478 TPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTP 537
Query: 1151 KKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNR---KQSS 1207
+ PPS + T +Q +E KP +Q+ A E P+ R + S
Sbjct: 538 AERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQR-AAEMEPPPEPKRRRVGDVEPS 596
Query: 1208 GKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRR 1243
K + R + SS ++R++ KRRR
Sbjct: 597 RKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRR 632
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 48.9 bits (115), Expect = 3e-05
Identities = 63/288 (21%), Positives = 109/288 (37%), Gaps = 23/288 (7%)
Query: 969 GPNSEDSIEEVKEDRNSHPPANLPTPASTRIL------RKYSNIRGKLRAQQRLIKNEK- 1021
G E I E + N + T ++ +K S R K R + R K +
Sbjct: 143 GSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSK 202
Query: 1022 --MECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEI 1079
+E SK + +P K Q P + ++ G K + ++
Sbjct: 203 GGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIG-KARSPTDD 261
Query: 1080 LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKK 1139
K E +SK K + K P + S+ + +++P R ++DR S+ ++
Sbjct: 262 KVKIEDKSKSK---------DRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKER 312
Query: 1140 TSLKE--NKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRP 1197
S + +K K P KS K S KE + ++RP +S +L+ + K S S
Sbjct: 313 KSKRSETDKEKKPIKSPSKDAS-SGKENRSPSRRPGRSPKRRSLSPKPRDKSR-RSRSPL 370
Query: 1198 QKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRRRLD 1245
KQS +R + +S + +RKR+ + S + R D
Sbjct: 371 LNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRD 418
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 48.9 bits (115), Expect = 3e-05
Identities = 49/199 (24%), Positives = 78/199 (39%), Gaps = 28/199 (14%)
Query: 1059 PVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSP---PDSKNKGPTVKASKEKHA 1115
P + KS R+ V ++ +S R RT+ SP P+ K K P + K
Sbjct: 172 PRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVK-- 229
Query: 1116 DGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQS 1175
K P+ + + + PK + E K P+K++ K KEKE T R
Sbjct: 230 ---VKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKK-----EKEKEKTRPRSRSR 281
Query: 1176 IASETLTK---PAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTP------------E 1220
S + T+ P+ + SR + + R++ S + R P +TP
Sbjct: 282 SKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRS 341
Query: 1221 SSAAQRKRKLKAKLDCSHS 1239
S +R+R+ A L S S
Sbjct: 342 RSPVRRRRRSSASLSGSSS 360
Score = 48.1 bits (113), Expect = 5e-05
Identities = 120/660 (18%), Positives = 229/660 (34%), Gaps = 125/660 (18%)
Query: 608 KEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKE 667
K +E GE++P + +A + + G K + K I E +A + ++ K+
Sbjct: 96 KNAREFMGELWPL---LLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKD 152
Query: 668 EPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLT 727
+ ++ + E++++K + S +P R P P+R +
Sbjct: 153 KR------------DKEEKESSREKRERSRSP--------------RRRKSRSPSPRRRS 186
Query: 728 SSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPK 787
S +E + + P+ S S P E T E P+
Sbjct: 187 SPV-------------------RRERKRSHSRSPRHRTKSRSPSPAPEKKEKT--PELPE 225
Query: 788 FMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRSR- 846
E QE A + +KV K + + +P+P +K +K KE + + RSR
Sbjct: 226 PSVKVKEPSVQE--ATSTSDILKVPKPE-PIPEPKEPSPEKNSKKEKEKEKTRPRSRSRS 282
Query: 847 KCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDVPPVKH- 905
K RS S+ S + + + + R + R+P PP +H
Sbjct: 283 KSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMP---PPPRHR 339
Query: 906 ----PLQKYAPSSLY----PSSLQAERLKKHLKKFPGAT--PAKNNWKMQKLWA----KF 951
P+++ SS SS + R + KK P T P + ++ + +
Sbjct: 340 RSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRH 399
Query: 952 RENPDQVEP----------------EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPA 995
R +P P + VSPG S + + K P+ P P
Sbjct: 400 RPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTS-GKVTKHKGTEKRESPSPAPKPR 458
Query: 996 STRILRKYSNIRGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDA 1055
+ + GK+ A + + + + + S S
Sbjct: 459 KVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSS----------------- 501
Query: 1056 DGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHA 1115
+PK + G G++ ++ S RKR + +SP + + P+ ++ + +
Sbjct: 502 -SEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRS 560
Query: 1116 DGATKTPAAKR----PAARDRSSQPPKKTSLKENKV----------KIPKKSAGKSCPPS 1161
P +R P R S PP++ S + P K S PP
Sbjct: 561 PSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPP 620
Query: 1162 RKEKENTNKRPSQSIASETLTKPAKQKGAGESSSR-PQKATNRKQSSGKTRARPSTKTPE 1220
K + + + P + ++ + P KQ+ + + R P ++ ++ S +R+ ++P+
Sbjct: 621 PKRRASPSPPPKRRVSH---SPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQ 677
Score = 40.0 bits (92), Expect = 0.014
Identities = 40/189 (21%), Positives = 89/189 (47%), Gaps = 35/189 (18%)
Query: 1080 LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGAT-KTPAAKRPAARDRSSQPPK 1138
+ + ++ S +K+ E D + K ++S+EK + + ++ P+ R RSS P
Sbjct: 136 IEQEKLASMKKQDEDKDKRDKEEK----ESSREKRERSRSPRRRKSRSPSPRRRSS--PV 189
Query: 1139 KTSLKENKVKIPK-KSAGKSCPPSRKEKENTNKRPSQSI------------ASETL---- 1181
+ K + + P+ ++ +S P+ ++KE T + P S+ S+ L
Sbjct: 190 RRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPK 249
Query: 1182 -------TKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKL 1234
+P+ +K + + + +K R +S K+R+R +++P + +R+ + +++
Sbjct: 250 PEPIPEPKEPSPEKNSKKEKEK-EKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSR- 307
Query: 1235 DCSHSKRRR 1243
S+S RRR
Sbjct: 308 --SYSPRRR 314
Score = 39.7 bits (91), Expect = 0.018
Identities = 32/139 (23%), Positives = 59/139 (42%), Gaps = 5/139 (3%)
Query: 1081 PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKT 1140
PK V + SSP +K + P++ + K + + T A+ P R S P+
Sbjct: 631 PKRRVSHSPPPKQRSSPV-TKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPR 689
Query: 1141 SLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKA 1200
+ + + P + G S P R++ + + RP + ++ K K K A S ++
Sbjct: 690 APQTSSSPPPVRR-GASSSPQRRQSPSPSTRPIRRVSRTPEPKKIK-KAASPSPQSVRRV 747
Query: 1201 TNRKQSSGKTRARPSTKTP 1219
++ + SG P+ K P
Sbjct: 748 SSSRSVSGS--PEPAAKKP 764
Score = 38.1 bits (87), Expect = 0.053
Identities = 35/154 (22%), Positives = 64/154 (41%), Gaps = 12/154 (7%)
Query: 1081 PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRS--SQPPK 1138
P+ +R+ PP +++ + + + + ++ ++R RS +PPK
Sbjct: 317 PRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPK 376
Query: 1139 KTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQ 1198
+TS K + SA PP R+ + + P + +T P Q+ SR
Sbjct: 377 RTSSPPRKTRRLSPSAS---PPRRRHRPS----PPATPPPKTRHSPTPQQSNRTRKSRVS 429
Query: 1199 KATNRKQSSGKTRARPSTKTPES-SAAQRKRKLK 1231
+ R +SGK T+ ES S A + RK++
Sbjct: 430 VSPGR--TSGKVTKHKGTEKRESPSPAPKPRKVE 461
Score = 35.8 bits (81), Expect = 0.26
Identities = 52/279 (18%), Positives = 108/279 (38%), Gaps = 31/279 (11%)
Query: 957 QVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRL 1016
Q E +D D +S + E + R + P S+ + R+ + R+ R
Sbjct: 147 QDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRE------RKRSHSRS 200
Query: 1017 IKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQV 1076
++ + A E K + P+ +++V +++ +K K + +
Sbjct: 201 PRHRTKSRSPSPAPEKKEKTPEL-------PEPSVKVKEPSVQEATSTSDILKVPKPEPI 253
Query: 1077 SEIL-PKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQ 1135
E P E SK+++ + + P S+++ K+ + + T +R +R RS
Sbjct: 254 PEPKEPSPEKNSKKEKEKEKTRPRSRSRS---KSRSRTRSRSPSHTRPRRRHRSRSRSYS 310
Query: 1136 PPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSI-----ASETLTKPAKQKGA 1190
P ++ S + + S + PP R ++R + +S +L+ + +
Sbjct: 311 PRRRPSPRR------RPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSS 364
Query: 1191 GESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRK 1229
S S P+K R S + R S P +S +R+ +
Sbjct: 365 SRSRSPPKKPPKRTSSPPRKTRRLS---PSASPPRRRHR 400
Score = 35.4 bits (80), Expect = 0.34
Identities = 29/150 (19%), Positives = 53/150 (35%), Gaps = 9/150 (6%)
Query: 1098 PDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKS 1157
P+ K P + KEK K R +R +S + S + + +S +S
Sbjct: 254 PEPKEPSPEKNSKKEKE-----KEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRS 308
Query: 1158 CPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKA----TNRKQSSGKTRAR 1213
P R+ P + + P + + + R +++ + SS +R+R
Sbjct: 309 YSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSR 368
Query: 1214 PSTKTPESSAAQRKRKLKAKLDCSHSKRRR 1243
K P + RK + + RRR
Sbjct: 369 SPPKKPPKRTSSPPRKTRRLSPSASPPRRR 398
Score = 32.3 bits (72), Expect = 2.9
Identities = 74/344 (21%), Positives = 112/344 (32%), Gaps = 61/344 (17%)
Query: 236 LTIPAPRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSS 295
L +P P + P+E +PE+ SK+ E+ PR + T+ + +
Sbjct: 245 LKVPKPE---PIPEPKEPSPEKNSKKEKEKEK----TRPRSRSRSKSRSRTRSRSPSHTR 297
Query: 296 PRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVP 355
PR + S P P P+ + P PP S
Sbjct: 298 PRRRHRSRSRSYSPRRRPSPRR----------RPSPRRRTPPRRMPPP----PRHRRSRS 343
Query: 356 QDCHLLPSTESFSGGVSEDVISRPHSPPE--------------IVSREESPQCSENQSSP 401
S+ S SG S SR SPP+ +S SP ++ SP
Sbjct: 344 PVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSP 403
Query: 402 MGLEPPMSLGKAEDNQS-----ISAEVESGDTQELNVDPLLKESSTFTDENPS------- 449
PP + QS V G T + K T E+PS
Sbjct: 404 PATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTS----GKVTKHKGTEKRESPSPAPKPRK 459
Query: 450 -ETEESEAAGGIGKLEGEDG-----DVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEAS 503
E ESE G GK+ D + +++ + D+ S E+ K+ K E
Sbjct: 460 VELSESEEDKG-GKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVG 518
Query: 504 DRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSK 547
R + S S SA R + ++S + P P +R +
Sbjct: 519 ---RRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRR 559
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 48.1 bits (113), Expect = 5e-05
Identities = 85/419 (20%), Positives = 160/419 (38%), Gaps = 68/419 (16%)
Query: 366 SFSGGVSEDVISRPHSPPEIVSRE------ESPQCSENQSSPMGLEPPMSLGKAEDNQSI 419
+F+G ++ + + H PP +S + E+P+ +E + K ED +S
Sbjct: 414 TFAGSITGPLYT--HRPPITISSKIQKPKVEAPKLKVQHKF---VEEIIEETKVEDEKSE 468
Query: 420 SAEVESGDTQELNVDPL--LKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKD 477
E + T+EL V KE++ +E P E EE E A ++ +VK
Sbjct: 469 MEEALTAITEELAVSMKEEKKEAAEEKEEEP-EAEEEEVAAKKSPVKATAPEVK------ 521
Query: 478 TYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKV 537
EE ++++G++ E D +S ++ ++
Sbjct: 522 --------EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE------------------- 554
Query: 538 PKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGII 597
K S+++ + E G T + E E E+ V E+ E ++E +
Sbjct: 555 -KEGSSEKEEGEQEEGETEAEA------EGEEAEAKEEKKVEEKSEEVATKEELVADAKV 607
Query: 598 TR-QTLKNMLDKEVKELRGEIFPSRDPITTAGQ-PLPGERLEIYVQSKMDEKNAHIPSES 655
+ + K+ + K E +G+ + P+ G+ P+P +E +S + + +S
Sbjct: 608 EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 667
Query: 656 IACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDES----DAPCSSLGLSSSGSG 711
K E+ + P +P VEEA ++ + +QK++E +AP
Sbjct: 668 PVSKSPVEEKAKSP--VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP------KEEKVE 719
Query: 712 DAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESG 770
PK VP K+ S A + + KV EKE + + +E ++G
Sbjct: 720 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG 778
Score = 47.4 bits (111), Expect = 9e-05
Identities = 71/312 (22%), Positives = 107/312 (34%), Gaps = 38/312 (12%)
Query: 956 DQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQR 1015
DQ E E GS+ E+ +E E ++ K + K +
Sbjct: 546 DQAE-EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK----EE 600
Query: 1016 LIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQ 1075
L+ + K+E P+ P KS SP V+ G PKS KG+
Sbjct: 601 LVADAKVEKPEKA---KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP-- 655
Query: 1076 VSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQ 1135
+PK+ V+ K K SP + K K P K+ E+ A ++ +
Sbjct: 656 ----VPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 711
Query: 1136 PPK--KTSLKENKVK-IPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK--------- 1183
PK K KE K K +P+K +S E S + E TK
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771
Query: 1184 PAKQKGAGESSSRPQKAT-----NRKQS-------SGKTRARPSTKTPESSAAQRKRKLK 1231
K+K GE S + + +RK+ GK TK S + K +
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 831
Query: 1232 AKLDCSHSKRRR 1243
LD S + ++
Sbjct: 832 NGLDLSPADEKK 843
Score = 34.7 bits (78), Expect = 0.58
Identities = 33/173 (19%), Positives = 68/173 (39%), Gaps = 19/173 (10%)
Query: 1061 KPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK 1120
KPK + K V EI+ + +V+ ++ E + ++ ++K K++ A+ +
Sbjct: 438 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 497
Query: 1121 TPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASET 1180
P A E + KKS K+ P KE+E + E
Sbjct: 498 EPEA-------------------EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 538
Query: 1181 LTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAK 1233
+ AK A E S + ++ +++ + + E + A+ ++K++ K
Sbjct: 539 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 591
Score = 33.5 bits (75), Expect = 1.3
Identities = 74/357 (20%), Positives = 133/357 (37%), Gaps = 46/357 (12%)
Query: 246 DVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASS 305
+ + E EE S+E+ + EE D K P K K + SP E+ +
Sbjct: 579 EAEAKEEKKVEEKSEEVATKEELVADAKVEK--------PEKAKSPVPKSPVEEKGKS-- 628
Query: 306 LVWPLPAHLPEEDLPEGGSTV-SAPTASGMSSP-------EHNQPPVALLDTEEMS---V 354
P+P EE +G S V +P SP E + PV+ EE + V
Sbjct: 629 ---PVPKSPVEE---KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 682
Query: 355 PQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAE 414
P+ P E+ S + E+ + + + + P +
Sbjct: 683 PKS----PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 738
Query: 415 DNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIG--KLEGEDGDVKC 472
++++ V + +++++ KE + + +E E AGG G + EG D K
Sbjct: 739 KEEAVAEVVTITKSVKVHLEKETKEEG----KPLQQEKEKEKAGGEGGSEEEGSDKGAKG 794
Query: 473 LSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSAC 532
++D +E ++++ K K ++ + + D S AD + D S
Sbjct: 795 SRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD---EKKGGDKS--- 848
Query: 533 LEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQ 589
E KV + ++ EG G T K + T+ +E+ E+ + S K E+
Sbjct: 849 -EEKVVVTKTVEKITSEGGDGAT--KYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 48.1 bits (113), Expect = 5e-05
Identities = 85/419 (20%), Positives = 160/419 (38%), Gaps = 68/419 (16%)
Query: 366 SFSGGVSEDVISRPHSPPEIVSRE------ESPQCSENQSSPMGLEPPMSLGKAEDNQSI 419
+F+G ++ + + H PP +S + E+P+ +E + K ED +S
Sbjct: 38 TFAGSITGPLYT--HRPPITISSKIQKPKVEAPKLKVQHKF---VEEIIEETKVEDEKSE 92
Query: 420 SAEVESGDTQELNVDPL--LKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKD 477
E + T+EL V KE++ +E P E EE E A ++ +VK
Sbjct: 93 MEEALTAITEELAVSMKEEKKEAAEEKEEEP-EAEEEEVAAKKSPVKATAPEVK------ 145
Query: 478 TYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKV 537
EE ++++G++ E D +S ++ ++
Sbjct: 146 --------EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE------------------- 178
Query: 538 PKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGII 597
K S+++ + E G T + E E E+ V E+ E ++E +
Sbjct: 179 -KEGSSEKEEGEQEEGETEAEA------EGEEAEAKEEKKVEEKSEEVATKEELVADAKV 231
Query: 598 TR-QTLKNMLDKEVKELRGEIFPSRDPITTAGQ-PLPGERLEIYVQSKMDEKNAHIPSES 655
+ + K+ + K E +G+ + P+ G+ P+P +E +S + + +S
Sbjct: 232 EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 291
Query: 656 IACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDES----DAPCSSLGLSSSGSG 711
K E+ + P +P VEEA ++ + +QK++E +AP
Sbjct: 292 PVSKSPVEEKAKSP--VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP------KEEKVE 343
Query: 712 DAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESG 770
PK VP K+ S A + + KV EKE + + +E ++G
Sbjct: 344 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG 402
Score = 47.4 bits (111), Expect = 9e-05
Identities = 71/312 (22%), Positives = 107/312 (34%), Gaps = 38/312 (12%)
Query: 956 DQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQR 1015
DQ E E GS+ E+ +E E ++ K + K +
Sbjct: 170 DQAE-EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK----EE 224
Query: 1016 LIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQ 1075
L+ + K+E P+ P KS SP V+ G PKS KG+
Sbjct: 225 LVADAKVEKPEKA---KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP-- 279
Query: 1076 VSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQ 1135
+PK+ V+ K K SP + K K P K+ E+ A ++ +
Sbjct: 280 ----VPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 335
Query: 1136 PPK--KTSLKENKVK-IPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTK--------- 1183
PK K KE K K +P+K +S E S + E TK
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
Query: 1184 PAKQKGAGESSSRPQKAT-----NRKQS-------SGKTRARPSTKTPESSAAQRKRKLK 1231
K+K GE S + + +RK+ GK TK S + K +
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
Query: 1232 AKLDCSHSKRRR 1243
LD S + ++
Sbjct: 456 NGLDLSPADEKK 467
Score = 34.7 bits (78), Expect = 0.58
Identities = 33/173 (19%), Positives = 68/173 (39%), Gaps = 19/173 (10%)
Query: 1061 KPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK 1120
KPK + K V EI+ + +V+ ++ E + ++ ++K K++ A+ +
Sbjct: 62 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 121
Query: 1121 TPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASET 1180
P A E + KKS K+ P KE+E + E
Sbjct: 122 EPEA-------------------EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 162
Query: 1181 LTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAK 1233
+ AK A E S + ++ +++ + + E + A+ ++K++ K
Sbjct: 163 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215
Score = 33.5 bits (75), Expect = 1.3
Identities = 74/357 (20%), Positives = 133/357 (37%), Gaps = 46/357 (12%)
Query: 246 DVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASS 305
+ + E EE S+E+ + EE D K P K K + SP E+ +
Sbjct: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEK--------PEKAKSPVPKSPVEEKGKS-- 252
Query: 306 LVWPLPAHLPEEDLPEGGSTV-SAPTASGMSSP-------EHNQPPVALLDTEEMS---V 354
P+P EE +G S V +P SP E + PV+ EE + V
Sbjct: 253 ---PVPKSPVEE---KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
Query: 355 PQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAE 414
P+ P E+ S + E+ + + + + P +
Sbjct: 307 PKS----PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 362
Query: 415 DNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIG--KLEGEDGDVKC 472
++++ V + +++++ KE + + +E E AGG G + EG D K
Sbjct: 363 KEEAVAEVVTITKSVKVHLEKETKEEG----KPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418
Query: 473 LSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSAC 532
++D +E ++++ K K ++ + + D S AD + D S
Sbjct: 419 SRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD---EKKGGDKS--- 472
Query: 533 LEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQ 589
E KV + ++ EG G T K + T+ +E+ E+ + S K E+
Sbjct: 473 -EEKVVVTKTVEKITSEGGDGAT--KYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 48.1 bits (113), Expect = 5e-05
Identities = 120/587 (20%), Positives = 217/587 (36%), Gaps = 79/587 (13%)
Query: 277 EPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPA---HLPEEDLPEGGSTVSAPTASG 333
EP E P KI+P P EE TA + P PA H+ + E A TA
Sbjct: 258 EPPSTEKFPAKIQP-----PLVEEATAKAE--PRPAEETHVQVQPSTEETPDAEAATAVA 310
Query: 334 MSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQ 393
+S + PP + + P + + ES S + +++ PP S EESP
Sbjct: 311 ENSVKVQPPPAE--EAPLVEFPAEIQPPSAEESPSVELLAEIL-----PP---SAEESP- 359
Query: 394 CSENQSSPMGLEPPMSLGKAEDNQSIS--AEVESGDTQE--LNVDPLLKESSTFTDENPS 449
++ P + PP AE + S+ E+ S Q+ + V PL E + +E P+
Sbjct: 360 ---SEEPPAEILPP----PAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGAL--EEAPA 410
Query: 450 ETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRS 509
+ E +E DV+ L ++ L+ + + ++ P L
Sbjct: 411 KVEPPT-------VEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPK 463
Query: 510 QLS--DSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHT 567
+ + ++S+ + L + E + P S + S +E H +P L ++
Sbjct: 464 ETTAEEASAEIQLLAATEPPADETPAEARSPL--SEETSAEEAHAEVQSP--LAEETTAE 519
Query: 568 ETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVK----------ELRGEI 617
E + + + E P++ E E ++ +T EV+ E E+
Sbjct: 520 EASAEIQLLAAIEAPAD---ETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576
Query: 618 FPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHI---PSESIACKRDPEQAKEEPGHIPT 674
P TTA + +L ++ +E A + P+E + P A+E P +
Sbjct: 577 QPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP 636
Query: 675 QHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAP---KSVPRPKRLTSSTY 731
EEA EV ++ E P + + A AP +S+P + T
Sbjct: 637 PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETL 696
Query: 732 NLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDVDTVVDEQPKFMEW 791
H+ + A + + +K + + ++ +E E+ +V EQ
Sbjct: 697 AAVHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEA-----SAEVSPPPSEQ------ 745
Query: 792 CAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEI 838
E++ L+ N + ++ Q I K G K +++ +I
Sbjct: 746 --TPEDEALVENVSTEFQSPQVAGIPAVKLGSVVLEGEAKFEEVSKI 790
Score = 45.1 bits (105), Expect = 4e-04
Identities = 104/506 (20%), Positives = 174/506 (34%), Gaps = 45/506 (8%)
Query: 271 DVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTA----SSLVWPLPAHLPEEDLPEGGSTV 326
+ + + EP+ E +++P+ +P +E TA S V P PA E L E + +
Sbjct: 276 EATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAE--EAPLVEFPAEI 333
Query: 327 SAPTASGMSSPE---HNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVS-EDVISRPHSP 382
P+A S E PP A E S +LP S V I P +
Sbjct: 334 QPPSAEESPSVELLAEILPPSA---EESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQ 390
Query: 383 PEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQS-ISAEVESGDTQELNVD-----PL 436
+ + P + +P +EPP D Q + E + +EL + P
Sbjct: 391 KAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPA 450
Query: 437 LKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKG 496
+ + F P ET EA+ I L +E +T ++ ++
Sbjct: 451 EEAPTEFQSPLPKETTAEEASAEIQLL--------AATEPPADETPAEARSPLSEETSAE 502
Query: 497 KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSK-KEGHPGGT 555
+ E ++ +SA+ L A +E + P+ +S E
Sbjct: 503 EAHAEVQSPLAEETTAEEASAEIQL--------LAAIEAPADETPAEAQSPLSEETSAEE 554
Query: 556 TPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVKELRG 615
P + S ++E E P + PS ++ E I + ++ E++
Sbjct: 555 APAEVQSPSAKGVSIE--EAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQP 612
Query: 616 EIFPSRDPITTAGQPLPGERLEIYVQ-SKMDEKNAHI---PSESIACKRDPEQAKEEPGH 671
P + QP P E VQ +E A + P+E + P A+E P
Sbjct: 613 ---PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 669
Query: 672 IPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTY 731
+ EEA EV + ++ E + + A K P L + +
Sbjct: 670 VQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEF 729
Query: 732 NLRHAHSLGSLDASKVTSEKEAAQVN 757
+ A + S S+ T E EA N
Sbjct: 730 PIGEASAEVSPPPSEQTPEDEALVEN 755
Score = 37.4 bits (85), Expect = 0.090
Identities = 67/261 (25%), Positives = 101/261 (38%), Gaps = 51/261 (19%)
Query: 206 VRTLARNLHSQEKASCSALASEAVFTPKQTLTIPAPRHTVDVQLP-REDNPEEPSKEITS 264
++ LA S E+A A P + PA +VQ P E+ P E
Sbjct: 593 IQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPA- 651
Query: 265 HEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGS 324
EE +V +P E P +++P P +EE A V LPA E + E +
Sbjct: 652 -EEAPAEV----QPPPAEEAPAEVQP-----PPAEEAPAE--VQSLPAE--ETPIEETLA 697
Query: 325 TVSAPTASGM----SSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPH 380
V +P A + +S + + PP LL TEE + G S +V
Sbjct: 698 AVHSPPADDVPAEEASVDKHSPPADLLLTEEFPI--------------GEASAEV----- 738
Query: 381 SPPEIVSREESPQCSEN-----QSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDP 435
SPP E EN QS + P + LG S+ E E+ + ++
Sbjct: 739 SPPPSEQTPEDEALVENVSTEFQSPQVAGIPAVKLG------SVVLEGEAKFEEVSKINS 792
Query: 436 LLKESSTFTDENPSETEESEA 456
+LK+ S T++ + T E E+
Sbjct: 793 VLKDLSN-TNDGQAPTLEIES 812
Score = 33.9 bits (76), Expect = 1.00
Identities = 69/340 (20%), Positives = 123/340 (36%), Gaps = 40/340 (11%)
Query: 911 APSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFRENPDQVEP-EDGSDVSPG 969
AP+ + P +++ E L P P + ++Q A E P + P E S +
Sbjct: 408 APAKVEPPTVE-ETLADVQPLLPEEAPREEARELQLSTAM--ETPAEEAPTEFQSPLPKE 464
Query: 970 PNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNEKMECPDALA 1029
+E++ E++ + PPA+ TPA R +++ + E LA
Sbjct: 465 TTAEEASAEIQLLAATEPPAD-ETPAEAR----------SPLSEETSAEEAHAEVQSPLA 513
Query: 1030 VESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKR 1089
E+ S I L A++ AD P + +S ++ S AEVQS
Sbjct: 514 EETTAEEASAEIQLLA----AIEAPADETPAEAQSP------LSEETSAEEAPAEVQSPS 563
Query: 1090 KRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSS--QPPKKTSLKENKV 1147
+ + + P+ + + + A A + AA +A + + QPP
Sbjct: 564 AKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQ 623
Query: 1148 KIPKKSAGKSC--PPSRKEKENTNKRPSQSIASETLTKPAKQKGA-----------GESS 1194
P + A PP+ + P++ +E PA++ A E
Sbjct: 624 PPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 683
Query: 1195 SRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKL 1234
S P + T +++ + P+ P A+ K A L
Sbjct: 684 SLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADL 723
Score = 32.7 bits (73), Expect = 2.2
Identities = 39/207 (18%), Positives = 79/207 (38%), Gaps = 14/207 (6%)
Query: 1023 ECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPK 1082
E PDA A + + SV + P + + L FP + + + + ++EILP
Sbjct: 299 ETPDAEAATAV-AENSVKVQPPPAEEAPLVE----FPAEIQPPSAEESPSVELLAEILPP 353
Query: 1083 AEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSL 1142
+ +S + P K P+V+ E + A K P +P P + +L
Sbjct: 354 SAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPL--------PAEGAL 405
Query: 1143 KENKVKIPKKSAGKSCPPSRK-EKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKAT 1201
+E K+ + ++ + E + ++ + T + ++ E S K T
Sbjct: 406 EEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKET 465
Query: 1202 NRKQSSGKTRARPSTKTPESSAAQRKR 1228
+++S + + +T+ P R
Sbjct: 466 TAEEASAEIQLLAATEPPADETPAEAR 492
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 49/259 (18%)
Query: 223 ALASEAVFTPKQTLTIPAPRHTVDVQLPRED--NPEE---------------PSKEITSH 265
+LAS A F+P+ IP P ++PRE+ +PE+ P+ I H
Sbjct: 1171 SLASPA-FSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVH 1229
Query: 266 EEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGST 325
G R E E T P L+ +P A PLP+ + P GG+
Sbjct: 1230 ATSNGQEPSRLGGAEEERPGT---PELAPAPMQSAAVAE----PLPSPRAQ---PPGGTP 1279
Query: 326 VSAPTASGMSSPEH------NQPPVALLDTEEMSVPQDCH--LLPSTESFSGGVSEDVIS 377
A G S E N PP L ++E + + L+P E F+ GV +++
Sbjct: 1280 ADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGV---LLA 1336
Query: 378 RPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL 437
P + P S SS EPP + A D + VE DT+ + DP L
Sbjct: 1337 TPLAGPGPSPTTVPSPASGKPSS----EPPPAPESAAD-----SGVEEADTRS-SSDPHL 1386
Query: 438 KESSTFTDENPSETEESEA 456
+ +ST + + T SE+
Sbjct: 1387 ETTSTISTVSSMSTLSSES 1405
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 47.0 bits (110), Expect = 1e-04
Identities = 66/318 (20%), Positives = 127/318 (39%), Gaps = 31/318 (9%)
Query: 276 KEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLP-EGGSTVSAPTASGM 334
+EP+E E C N+ SS S++T+ SS+ P L + S ++ ++
Sbjct: 12 QEPEEDEDCYIL---NVQSS--SDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVAR 66
Query: 335 SSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVSEDVISRPHSPPEIVSREESPQC 394
+P+ V ++D++ ++CH ++ EI S +ESP+C
Sbjct: 67 RAPKRQASSVVVIDSDS---DEECHTHEEKKA--------------KLLEINSDDESPEC 109
Query: 395 SENQSSPMGLEPPMSLGKAE--DNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETE 452
+ P EPP+ + + D+ EV ++ + + S D+N ++E
Sbjct: 110 CHVK--PAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSE 167
Query: 453 ESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDRCLRSQLS 512
+ + ++ D + + ++ D+S D+ +++ D P+ D+ S +
Sbjct: 168 APDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPD--DKSDDSDVP 225
Query: 513 DSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPD--SFHTETL 570
D SS D + + SSD S A + S P ++ PD S +E
Sbjct: 226 DDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAS 285
Query: 571 EDTEKPSVNERPSEKDAE 588
+D+ S S D+E
Sbjct: 286 DDSSDDSEASDDSSDDSE 303
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 46.6 bits (109), Expect = 1e-04
Identities = 116/586 (19%), Positives = 191/586 (32%), Gaps = 66/586 (11%)
Query: 185 KTARKSTRGYFFNGDCCELPTVRTLA----RNLHSQEKASCSALASEAVFTPKQTLTIPA 240
+ A K +RG + D C PTV + L+SQ + LA + +P P
Sbjct: 1021 RAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKH---LAPPPLLSPLLPSIKPT 1077
Query: 241 PRHT--------VDVQLPREDNPEEPSKEITSHEEG------GGDVSPRKEPQEPEVCPT 286
R T + L E P P +I + + +P P P
Sbjct: 1078 VRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPV 1137
Query: 287 KIKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVAL 346
KP S + RS T SS+ P P +L ST T+ S + +
Sbjct: 1138 TPKPT-SQATRSR-TNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSS 1195
Query: 347 LDTEEMSVPQDCHLLPSTESFSGGVSEDVI---------SRPHSPPEIVSREESPQCSEN 397
+ T E VP L PST + SE S +P +V Q S +
Sbjct: 1196 VKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTS 1255
Query: 398 QSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAA 457
P+ EP + N+S E + P T + S T S
Sbjct: 1256 TDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTN 1315
Query: 458 GGIGKLEGEDGDVKCLSEKDTYDTSIDSLEE-NLDKKKKGKKFPEASDRCLRSQLSDSS- 515
+S T +T + + E + P+ + R RS+ + SS
Sbjct: 1316 ---------------MSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSV 1360
Query: 516 -SADRCLRNQSSDSSSACLEIKVPKNPSAKRSK-KEGHPGGTTPKGLLPDSFHTETLEDT 573
+ + + S E V P+++ ++ ++ G TP+ L+P + E T
Sbjct: 1361 KNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTST 1420
Query: 574 EKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPG 633
++P V P+ + + T +T+ P P T+ QP+
Sbjct: 1421 DQP-VTPEPTSQATRGRTNRSSVKTPETVV------------PTAPELQPSTSTDQPVTP 1467
Query: 634 ERLEIYVQSKMDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKD 693
E + + D + P E++ QA T + K
Sbjct: 1468 EPTSQATRGRTDRSSVKTP-ETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKT 1526
Query: 694 DESDAPCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSL 739
E+ P + L S S D P+ R R ++ +++ S+
Sbjct: 1527 PETVVPAAP-ELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESI 1571
Score = 38.9 bits (89), Expect = 0.031
Identities = 108/546 (19%), Positives = 181/546 (33%), Gaps = 92/546 (16%)
Query: 234 QTLTIPAPRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKE-PQEPEVCPTK----- 287
+TL AP+ + PE S+ +P P PE+ P+
Sbjct: 1405 ETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQP 1464
Query: 288 IKPNLSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALL 347
+ P +S T SS+ P +L ST T+ S + + +
Sbjct: 1465 VTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSV 1524
Query: 348 DTEEMSVPQDCHLLPSTESFS------------GGVSEDVISRPHS-------------- 381
T E VP L PST + G + + P S
Sbjct: 1525 KTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSR 1584
Query: 382 ----PPEIVSREESPQCSENQSSPMGLEP-----PMSLGKAEDNQSISAEVESGDTQELN 432
PE SR + +C N+SS EP P +Q ++ ++ S T+
Sbjct: 1585 NQLVTPEPTSR--ATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKT 1642
Query: 433 ----------VDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTS 482
V+P + FT + S T E+ A GG K V+ + T +
Sbjct: 1643 NRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTL-RSSTVRAMPVPTTPEF- 1700
Query: 483 IDSLEENLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPS 542
+ P +D+ + + S C++ Q + + L + P
Sbjct: 1701 ---------------QSPVTTDQPISPEPITQPS---CIKRQRAAGNPGSLAAPIDHKPC 1742
Query: 543 AKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTL 602
+ + + G + + + + P + E P Q+ E G R
Sbjct: 1743 SAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAG---RSRF 1799
Query: 603 KNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKN-AHIPS--ESIAC- 658
L + + R + D QP GE + V K +E++ A P E +
Sbjct: 1800 TPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTP 1859
Query: 659 ---KRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQK-------DDESDAPCSSLGLSSS 708
KR +QA+EEP IP++ + +++ E+T K D + +LG S +
Sbjct: 1860 KPGKRKRDQAEEEPNRIPSRSLRR--TKLNQESTAPKVLFTGVVDARGERAVLALGGSLA 1917
Query: 709 GSGDAA 714
GS A
Sbjct: 1918 GSAAEA 1923
Score = 38.5 bits (88), Expect = 0.040
Identities = 82/365 (22%), Positives = 135/365 (36%), Gaps = 55/365 (15%)
Query: 898 GDVP-PVKHPLQKYAPSSLYPSSLQAERLKKHLK--KFPGATPAKNNWKMQKLWAKFREN 954
GD+P P P+ + S S + R +K L K P A A +K+ +E+
Sbjct: 974 GDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQES 1033
Query: 955 PDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANL-PTPASTRILRKYSNIRGKLRAQ 1013
PD P P ++ ++ NS +L P P + +L +I+ +R
Sbjct: 1034 PDACLP---------PTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLL---PSIKPTVRKT 1081
Query: 1014 QRLIKNEKMECPDALAVES---KP---SRKSVCINPLMSPKLALQVD---ADGFPVKPKS 1064
++ E E P + +E KP +RKS + P + A + + PV PK
Sbjct: 1082 RQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKP 1141
Query: 1065 TEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAA 1124
T + + S P+ V + + +S PT + ++ + + + KTP
Sbjct: 1142 TSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPET 1201
Query: 1125 KRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENT-----NKRPSQSIASE 1179
P A + QP T + + G+ S K E +PS S
Sbjct: 1202 VVPTALE--LQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQP 1259
Query: 1180 TLTKPAKQKGAGESSS----------------RPQKATNR----KQSSGKTRAR---PST 1216
++P Q G + RP +T+R K +S TR+R S
Sbjct: 1260 VTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSV 1319
Query: 1217 KTPES 1221
KTPE+
Sbjct: 1320 KTPET 1324
Score = 36.6 bits (83), Expect = 0.15
Identities = 43/190 (22%), Positives = 76/190 (40%), Gaps = 22/190 (11%)
Query: 1033 KPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGMKGRK-GKQVSEILPKAEVQSKRKR 1091
K +V I P + P + + P ++T G K R GK ++P A
Sbjct: 1361 KNPESTVPIAPELPPSTSTEQPVTPEPTS-RATRGRKNRSSGKTPETLVPTAPKLEPSTS 1419
Query: 1092 TEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPK 1151
T+ P+ PT +A++ + + KTP P A P + S ++ P+
Sbjct: 1420 TDQPVTPE-----PTSQATRGRTNRSSVKTPETVVPTA------PELQPSTSTDQPVTPE 1468
Query: 1152 KSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTR 1211
P S+ + T++ S ET+ A + A S+ +P + +++ +
Sbjct: 1469 -------PTSQATRGRTDR--SSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRK 1519
Query: 1212 ARPSTKTPES 1221
R S KTPE+
Sbjct: 1520 NRSSVKTPET 1529
Score = 35.4 bits (80), Expect = 0.34
Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 16/176 (9%)
Query: 1046 SPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGP 1105
+P+L + D PV PK T + S P++ V + +S P
Sbjct: 1329 APELQISTSTDQ-PVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEP 1387
Query: 1106 TVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEK 1165
T +A++ + + KTP P A P + S ++ P+ P S+ +
Sbjct: 1388 TSRATRGRKNRSSGKTPETLVPTA------PKLEPSTSTDQPVTPE-------PTSQATR 1434
Query: 1166 ENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPES 1221
TN+ S ET+ A + S+ +P Q++ R S KTPE+
Sbjct: 1435 GRTNR--SSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPET 1488
Score = 35.0 bits (79), Expect = 0.45
Identities = 35/144 (24%), Positives = 56/144 (38%), Gaps = 24/144 (16%)
Query: 1106 TVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKV------KIPKKSAGKSCP 1159
T +A++ K + KTP PAA D P S+ + K + S ++ P
Sbjct: 1634 TSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMP 1693
Query: 1160 PSRKEKENTNKRPSQSIASETLTKPA---KQKGAGESSS--------------RPQKATN 1202
+ + Q I+ E +T+P+ +Q+ AG S P+ +
Sbjct: 1694 VPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQAS 1753
Query: 1203 RKQSSGKTRARPS-TKTPESSAAQ 1225
R Q G RA S T PE ++ Q
Sbjct: 1754 RNQRWGAVRAAESLTAIPEPASPQ 1777
Score = 32.3 bits (72), Expect = 2.9
Identities = 49/202 (24%), Positives = 78/202 (38%), Gaps = 25/202 (12%)
Query: 1025 PDALAVESKPSRKSVCINPLM---SPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEILP 1081
P + A + +R SV + +P+L D PV P+ T + + S P
Sbjct: 1428 PTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQ-PVTPEPTSQATRGRTDRSSVKTP 1486
Query: 1082 KAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTS 1141
+ V + + +S PT + ++ + + KTP PAA P + S
Sbjct: 1487 ETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAA------PELQPS 1540
Query: 1142 LKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKAT 1201
++ P+ P SR + TN+ ++ S P Q S+SR Q T
Sbjct: 1541 TSTDQPVTPE-------PTSRATRGRTNRSSVKTPESIVPIAPELQ----PSTSRNQLVT 1589
Query: 1202 NRKQSSGKTRA---RPSTKTPE 1220
+ +S TR R S KTPE
Sbjct: 1590 -PEPTSRATRCRTNRSSVKTPE 1610
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 46.6 bits (109), Expect = 1e-04
Identities = 167/807 (20%), Positives = 296/807 (36%), Gaps = 119/807 (14%)
Query: 523 NQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERP 582
N+ + S L + + +P R ++E + GG + + S + E L + + +
Sbjct: 822 NRENFSPERFLPLNIRNSPFT-RGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNT 880
Query: 583 SEKDAEQEGEGGGIITRQTLKNMLDKEVKELRGEIFP--------SRDPI------TTAG 628
K+ E E G + K+ ++ +E G + P SR+P T +
Sbjct: 881 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 940
Query: 629 QPLPGERLEIYVQSK-MDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNE 687
LP V+ + MD ++ S S KR+ ++ K + ++ AV++ +N
Sbjct: 941 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1000
Query: 688 NTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVP---RPKRLTSSTYNLRHAHSLGSLDA 744
K G G+ R+P+S P + K T T N + + S S
Sbjct: 1001 VKPAK-----------GPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSS--SQKD 1047
Query: 745 SKVT---------SEKEAAQVNPIMPKENGASESGDPLDE-----DDVDTVVDEQPKFME 790
K+T S KE + P+ ++ S D E ++ +E+ K ++
Sbjct: 1048 EKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD 1107
Query: 791 WCAEE-----ENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRS 845
E+ E + + +F + MK+ K +++ + +P+P+ + + D K +
Sbjct: 1108 NKGEKRKRKTEEKGVDKDFESSSMKISK--LEVTEIVKPSPKRKMEPDTEK----MDRTP 1161
Query: 846 RKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDVPPVKH 905
K + SL S +++ T K+ + T ++ K+ + +L VK
Sbjct: 1162 EKDKISL-SAPAKKIKLNRETGKKIGS----------TENISNTKEPSEKLESTSSKVK- 1209
Query: 906 PLQKYAPSSLYPSSLQAERLKKHLKKFP-----GATPA-----KNNWKMQKLWAKFRENP 955
Q+ + E L + G +P K + K + N
Sbjct: 1210 --QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1267
Query: 956 DQVEP-EDGSDVSPGPNSE---DSIEEVKED-RNSHPPANLPTPAST--RILRKYSNI-- 1006
D P ED + P S+ D E +ED +++ P +++ PAS + K SNI
Sbjct: 1268 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1327
Query: 1007 --RGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPK- 1063
+ +++ K K + + E K S+ S + V P K K
Sbjct: 1328 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1387
Query: 1064 STEGMK-------GRKG--KQVSEILPKAEVQSKRKRTEGSSPPD------SKNKGPTVK 1108
ST+ K +G K +S+ +A K T SS D K T +
Sbjct: 1388 STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTRE 1447
Query: 1109 ASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKS----CPPSRKE 1164
S K D + K +R++ S +K +E + +PKK G S PSR
Sbjct: 1448 YSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREER-DLPKKGTGDSKKSNSSPSRDR 1506
Query: 1165 KENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRA----RPSTKTPE 1220
K + +K + TK + + +A N K+SSG P T+ +
Sbjct: 1507 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1566
Query: 1221 SSAAQR--KRKLKAKLDCSHSKRRRLD 1245
+ K +K K SHS R D
Sbjct: 1567 EQITGQIDKSTVKPKPQLSHSSRLSSD 1593
Score = 41.2 bits (95), Expect = 0.006
Identities = 157/861 (18%), Positives = 309/861 (35%), Gaps = 120/861 (13%)
Query: 423 VESGDTQELNVDPLLKESSTFTDEN-PSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDT 481
VE T L V P +++ DE +E+ ++ K E + K K D
Sbjct: 932 VEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG 991
Query: 482 SIDSLEENLDKKKKG--KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL-EIKVP 538
S S +EN+ K KG +K +R RS+ + + + ++ SSS+ + K+
Sbjct: 992 SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKIT 1051
Query: 539 KNPSAKRSKKEGHPGGTTP----KGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGG 594
P SK T P K S ++ + T K ++P+EK+ + +G
Sbjct: 1052 GTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGE 1111
Query: 595 GIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQS-----KMDEKNA 649
R+T + +DK+ + +I S+ +T +P P ++E + + D+ +
Sbjct: 1112 KR-KRKTEEKGVDKDFESSSMKI--SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL 1168
Query: 650 HIPSESIACKRDPEQAKEEPGHI-----PTQHVEEAVNEVDNENTQQK-------DDESD 697
P++ I R+ + +I P++ +E ++V E + K + S
Sbjct: 1169 SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSS 1228
Query: 698 APCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVN 757
+ +SS G R + KR T + + T+ E +
Sbjct: 1229 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDN---------TAPAEDVIIM 1279
Query: 758 PIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQ 817
+P+ D+DD ++ ++ + + +I N + + + K
Sbjct: 1280 IQVPQSKW--------DKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK---Y 1328
Query: 818 LEKEGQPTPRARN-KSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKW 876
EKE +P+ + + D EI + + +S K +S E K
Sbjct: 1329 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK-------------------- 1368
Query: 877 FLETTETRSLVIVKKLNT--RLPGDVPPVKHPLQKYAPS----SLYPSSLQAERLKKHLK 930
T+ R +++K N R P + L + SL SS +A KH
Sbjct: 1369 ----TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH-- 1422
Query: 931 KFPGATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPAN 990
+T A +N F N D+ D + S ++ E + R P N
Sbjct: 1423 ---DSTRASSN-------KDFTPNRDKKTDYDTREYSSSKRRDEKNELTR--RKDSPSRN 1470
Query: 991 LPTPASTRILRKYSNIRGKLRAQQRLIKN---EKMECPDALAVESKPSRKSVCINPLMSP 1047
+ S + K R ++ L K + + + + + KP +
Sbjct: 1471 KDSA---------SGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN 1521
Query: 1048 KLALQVDADGFPVKPKSTEGMKGRKGKQVSE-----ILPKAEVQSKRKRTEGSSPPDSKN 1102
+ VD + P K + ++ R K+ S IL E Q ++++ G +
Sbjct: 1522 EETKSVDKN--PCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1579
Query: 1103 KGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSR 1162
P + S +D +T A + +P S E+ V + ++ + +
Sbjct: 1580 PKPQLSHSSRLSSDLTRETDEA--------AFEPDYNESDSESNVSVKEEESSGNISKDL 1631
Query: 1163 KEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESS 1222
K+K + S A+ ++ + S P ++ + S ++ + ++
Sbjct: 1632 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1691
Query: 1223 AAQRKRKLKAKLDCSHSKRRR 1243
+ ++K+K + K H K ++
Sbjct: 1692 SKKKKKKKEKKKHKKHKKHKK 1712
Score = 34.3 bits (77), Expect = 0.76
Identities = 123/627 (19%), Positives = 220/627 (35%), Gaps = 114/627 (18%)
Query: 251 REDNPEEPSKEITSHEEGGGDVSPRKEPQE------------PEVCPTKIKPNLSSSPRS 298
++DN + KE + + G G + K+ ++ PE+ T K S P
Sbjct: 876 QKDNTKSKEKE-SENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK---SREPTG 931
Query: 299 EETTASSLVWPLPAH---LPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMS-- 353
E + ++ LP+ P D P +++ + S E ++P T+ +
Sbjct: 932 VEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG 991
Query: 354 --VPQDCHLLPSTESFSGGVSEDVISRPHSPPEIV-SREESPQCSENQSSPMGLEPPMSL 410
V + +++ + V + P S P I ++EE+P+ +SS +
Sbjct: 992 SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKIT 1051
Query: 411 GKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGK---LEGED 467
G S SA+ E +T+ + + + K+ S T+E +A K L+ +
Sbjct: 1052 GTPRKAHSKSAK-EHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG 1110
Query: 468 GDVKCLSEKDTYDTSIDSLEENLDK-----------KKKGKKFPEASDRCL-RSQLSDSS 515
K +E+ D +S + K K+K + E DR + ++S S+
Sbjct: 1111 EKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSA 1170
Query: 516 SADRCLRNQSSDSSSACLE-IKVPKNPSAK------RSKKEGHPGGTTPKGLLPDSFHTE 568
A + N+ + E I K PS K + K+E G K + +
Sbjct: 1171 PAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSST 1230
Query: 569 TLEDTEKPSVNERPSEKDAEQEGEGGGIITR-------------------QTLKNMLDKE 609
++ T S P K E+ +I Q ++ DK+
Sbjct: 1231 LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1290
Query: 610 VKELRGEIFPSRDPITTAGQPL----------------------PGERLEIYVQSKMDEK 647
E E S PI++ G+P P E+++ + + E
Sbjct: 1291 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1350
Query: 648 NAHIPSESIACKRDPEQAKEEPGHIPTQ--HVEEAVNEVDNENTQQKDDESD-------A 698
H K A E G + V E N +N+ Q + ES+
Sbjct: 1351 IQH------EVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1404
Query: 699 PCSSLGLSS-----SGSGDAARAPKSVP-RPKRLTSSTYNLRHAHSLGSLD-ASKVTSEK 751
SL SS S D+ RA + P R + Y+ R S D +++T K
Sbjct: 1405 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRK 1464
Query: 752 EAAQVNPIMPKENGASESGDPLDEDDV 778
+ +P K++ + + P +E D+
Sbjct: 1465 D----SPSRNKDSASGQKNKPREERDL 1487
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 46.6 bits (109), Expect = 1e-04
Identities = 167/807 (20%), Positives = 296/807 (36%), Gaps = 119/807 (14%)
Query: 523 NQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERP 582
N+ + S L + + +P R ++E + GG + + S + E L + + +
Sbjct: 856 NRENFSPERFLPLNIRNSPFT-RGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNT 914
Query: 583 SEKDAEQEGEGGGIITRQTLKNMLDKEVKELRGEIFP--------SRDPI------TTAG 628
K+ E E G + K+ ++ +E G + P SR+P T +
Sbjct: 915 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
Query: 629 QPLPGERLEIYVQSK-MDEKNAHIPSESIACKRDPEQAKEEPGHIPTQHVEEAVNEVDNE 687
LP V+ + MD ++ S S KR+ ++ K + ++ AV++ +N
Sbjct: 975 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1034
Query: 688 NTQQKDDESDAPCSSLGLSSSGSGDAARAPKSVP---RPKRLTSSTYNLRHAHSLGSLDA 744
K G G+ R+P+S P + K T T N + + S S
Sbjct: 1035 VKPAK-----------GPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSS--SQKD 1081
Query: 745 SKVT---------SEKEAAQVNPIMPKENGASESGDPLDE-----DDVDTVVDEQPKFME 790
K+T S KE + P+ ++ S D E ++ +E+ K ++
Sbjct: 1082 EKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLD 1141
Query: 791 WCAEE-----ENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLKEIWKSKKRS 845
E+ E + + +F + MK+ K +++ + +P+P+ + + D K +
Sbjct: 1142 NKGEKRKRKTEEKGVDKDFESSSMKISK--LEVTEIVKPSPKRKMEPDTEK----MDRTP 1195
Query: 846 RKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDVPPVKH 905
K + SL S +++ T K+ + T ++ K+ + +L VK
Sbjct: 1196 EKDKISL-SAPAKKIKLNRETGKKIGS----------TENISNTKEPSEKLESTSSKVK- 1243
Query: 906 PLQKYAPSSLYPSSLQAERLKKHLKKFP-----GATPA-----KNNWKMQKLWAKFRENP 955
Q+ + E L + G +P K + K + N
Sbjct: 1244 --QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1301
Query: 956 DQVEP-EDGSDVSPGPNSE---DSIEEVKED-RNSHPPANLPTPAST--RILRKYSNI-- 1006
D P ED + P S+ D E +ED +++ P +++ PAS + K SNI
Sbjct: 1302 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1361
Query: 1007 --RGKLRAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPK- 1063
+ +++ K K + + E K S+ S + V P K K
Sbjct: 1362 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1421
Query: 1064 STEGMK-------GRKG--KQVSEILPKAEVQSKRKRTEGSSPPD------SKNKGPTVK 1108
ST+ K +G K +S+ +A K T SS D K T +
Sbjct: 1422 STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTRE 1481
Query: 1109 ASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKS----CPPSRKE 1164
S K D + K +R++ S +K +E + +PKK G S PSR
Sbjct: 1482 YSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREER-DLPKKGTGDSKKSNSSPSRDR 1540
Query: 1165 KENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRA----RPSTKTPE 1220
K + +K + TK + + +A N K+SSG P T+ +
Sbjct: 1541 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1600
Query: 1221 SSAAQR--KRKLKAKLDCSHSKRRRLD 1245
+ K +K K SHS R D
Sbjct: 1601 EQITGQIDKSTVKPKPQLSHSSRLSSD 1627
Score = 41.2 bits (95), Expect = 0.006
Identities = 157/861 (18%), Positives = 309/861 (35%), Gaps = 120/861 (13%)
Query: 423 VESGDTQELNVDPLLKESSTFTDEN-PSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDT 481
VE T L V P +++ DE +E+ ++ K E + K K D
Sbjct: 966 VEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG 1025
Query: 482 SIDSLEENLDKKKKG--KKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACL-EIKVP 538
S S +EN+ K KG +K +R RS+ + + + ++ SSS+ + K+
Sbjct: 1026 SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKIT 1085
Query: 539 KNPSAKRSKKEGHPGGTTP----KGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGG 594
P SK T P K S ++ + T K ++P+EK+ + +G
Sbjct: 1086 GTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGE 1145
Query: 595 GIITRQTLKNMLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQS-----KMDEKNA 649
R+T + +DK+ + +I S+ +T +P P ++E + + D+ +
Sbjct: 1146 KR-KRKTEEKGVDKDFESSSMKI--SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL 1202
Query: 650 HIPSESIACKRDPEQAKEEPGHI-----PTQHVEEAVNEVDNENTQQK-------DDESD 697
P++ I R+ + +I P++ +E ++V E + K + S
Sbjct: 1203 SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSS 1262
Query: 698 APCSSLGLSSSGSGDAARAPKSVPRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVN 757
+ +SS G R + KR T + + T+ E +
Sbjct: 1263 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDN---------TAPAEDVIIM 1313
Query: 758 PIMPKENGASESGDPLDEDDVDTVVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQ 817
+P+ D+DD ++ ++ + + +I N + + + K
Sbjct: 1314 IQVPQSKW--------DKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK---Y 1362
Query: 818 LEKEGQPTPRARN-KSDKLKEIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKW 876
EKE +P+ + + D EI + + +S K +S E K
Sbjct: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK-------------------- 1402
Query: 877 FLETTETRSLVIVKKLNT--RLPGDVPPVKHPLQKYAPS----SLYPSSLQAERLKKHLK 930
T+ R +++K N R P + L + SL SS +A KH
Sbjct: 1403 ----TKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH-- 1456
Query: 931 KFPGATPAKNNWKMQKLWAKFRENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPAN 990
+T A +N F N D+ D + S ++ E + R P N
Sbjct: 1457 ---DSTRASSN-------KDFTPNRDKKTDYDTREYSSSKRRDEKNELTR--RKDSPSRN 1504
Query: 991 LPTPASTRILRKYSNIRGKLRAQQRLIKN---EKMECPDALAVESKPSRKSVCINPLMSP 1047
+ S + K R ++ L K + + + + + KP +
Sbjct: 1505 KDSA---------SGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN 1555
Query: 1048 KLALQVDADGFPVKPKSTEGMKGRKGKQVSE-----ILPKAEVQSKRKRTEGSSPPDSKN 1102
+ VD + P K + ++ R K+ S IL E Q ++++ G +
Sbjct: 1556 EETKSVDKN--PCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613
Query: 1103 KGPTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSR 1162
P + S +D +T A + +P S E+ V + ++ + +
Sbjct: 1614 PKPQLSHSSRLSSDLTRETDEA--------AFEPDYNESDSESNVSVKEEESSGNISKDL 1665
Query: 1163 KEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESS 1222
K+K + S A+ ++ + S P ++ + S ++ + ++
Sbjct: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1725
Query: 1223 AAQRKRKLKAKLDCSHSKRRR 1243
+ ++K+K + K H K ++
Sbjct: 1726 SKKKKKKKEKKKHKKHKKHKK 1746
Score = 34.3 bits (77), Expect = 0.76
Identities = 123/627 (19%), Positives = 220/627 (35%), Gaps = 114/627 (18%)
Query: 251 REDNPEEPSKEITSHEEGGGDVSPRKEPQE------------PEVCPTKIKPNLSSSPRS 298
++DN + KE + + G G + K+ ++ PE+ T K S P
Sbjct: 910 QKDNTKSKEKE-SENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK---SREPTG 965
Query: 299 EETTASSLVWPLPAH---LPEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMS-- 353
E + ++ LP+ P D P +++ + S E ++P T+ +
Sbjct: 966 VEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG 1025
Query: 354 --VPQDCHLLPSTESFSGGVSEDVISRPHSPPEIV-SREESPQCSENQSSPMGLEPPMSL 410
V + +++ + V + P S P I ++EE+P+ +SS +
Sbjct: 1026 SAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKIT 1085
Query: 411 GKAEDNQSISAEVESGDTQELNVDPLLKESSTFTDENPSETEESEAAGGIGK---LEGED 467
G S SA+ E +T+ + + + K+ S T+E +A K L+ +
Sbjct: 1086 GTPRKAHSKSAK-EHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKG 1144
Query: 468 GDVKCLSEKDTYDTSIDSLEENLDK-----------KKKGKKFPEASDRCL-RSQLSDSS 515
K +E+ D +S + K K+K + E DR + ++S S+
Sbjct: 1145 EKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSA 1204
Query: 516 SADRCLRNQSSDSSSACLE-IKVPKNPSAK------RSKKEGHPGGTTPKGLLPDSFHTE 568
A + N+ + E I K PS K + K+E G K + +
Sbjct: 1205 PAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSST 1264
Query: 569 TLEDTEKPSVNERPSEKDAEQEGEGGGIITR-------------------QTLKNMLDKE 609
++ T S P K E+ +I Q ++ DK+
Sbjct: 1265 LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKD 1324
Query: 610 VKELRGEIFPSRDPITTAGQPL----------------------PGERLEIYVQSKMDEK 647
E E S PI++ G+P P E+++ + + E
Sbjct: 1325 DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEI 1384
Query: 648 NAHIPSESIACKRDPEQAKEEPGHIPTQ--HVEEAVNEVDNENTQQKDDESD-------A 698
H K A E G + V E N +N+ Q + ES+
Sbjct: 1385 IQH------EVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQG 1438
Query: 699 PCSSLGLSS-----SGSGDAARAPKSVP-RPKRLTSSTYNLRHAHSLGSLD-ASKVTSEK 751
SL SS S D+ RA + P R + Y+ R S D +++T K
Sbjct: 1439 NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRK 1498
Query: 752 EAAQVNPIMPKENGASESGDPLDEDDV 778
+ +P K++ + + P +E D+
Sbjct: 1499 D----SPSRNKDSASGQKNKPREERDL 1521
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 46.6 bits (109), Expect = 1e-04
Identities = 64/291 (21%), Positives = 114/291 (39%), Gaps = 38/291 (13%)
Query: 961 EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNE 1020
E G DVSP P S S + R+ + P L +R YS+ + R++ RL +
Sbjct: 377 ERGGDVSPSPYSSSS---WRRSRSPYSPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSR-- 430
Query: 1021 KMECPDALAVESKPSRKSVCINPL-MSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEI 1079
S+ S+ + L + LA +++ + K ++ E + + + +E
Sbjct: 431 -----------SRSRHSSISPSTLTLKSSLAAELNKN---KKARAAEAARAAEAAKAAEA 476
Query: 1080 LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK-------TPAAKRPAARDR 1132
AE +K + +S P N + AS+ H K +P++ D+
Sbjct: 477 TKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDK 536
Query: 1133 S-SQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQK-GA 1190
+ ++PP + + EN + I K+ K+ ++ K K S S+ + TKP GA
Sbjct: 537 AKTKPPLQVTKVENNL-IVDKATKKAVIVGKESKSAATKEESVSLKEK--TKPLTPSIGA 593
Query: 1191 GESSSRPQKATNRKQSSGKTRARPSTKTPES-----SAAQRKRKLKAKLDC 1236
E T+ P K +S S K++++ KL C
Sbjct: 594 KEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRC 644
Score = 32.0 bits (71), Expect = 3.8
Identities = 23/139 (16%), Positives = 57/139 (41%), Gaps = 5/139 (3%)
Query: 1105 PTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKE 1164
P + ++ +G+ + RP RSS K +E++ + ++ ++ +
Sbjct: 181 PASSSGTQRRGEGSER-----RPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRH 235
Query: 1165 KENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAA 1224
+ +R + + + + ++K A +SS +R + ++R + S + P +
Sbjct: 236 SHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295
Query: 1225 QRKRKLKAKLDCSHSKRRR 1243
K + K + +RRR
Sbjct: 296 PPKAYREDKTEPKAYRRRR 314
Score = 30.8 bits (68), Expect = 8.4
Identities = 35/155 (22%), Positives = 60/155 (38%), Gaps = 15/155 (9%)
Query: 1061 KPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK 1120
K +S G + +V++ + +RK +S S K KA + ++
Sbjct: 230 KSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHR-------SR 282
Query: 1121 TPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASET 1180
T ++K P + + +PPK + + K ++ S P ++ + R SQS+ S
Sbjct: 283 TKSSKEPPSAYK--EPPKAYREDKTEPKAYRRRRSLS-PLGGRDDSPVSHRASQSLRSRK 339
Query: 1181 LTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPS 1215
P AG SS + R S R PS
Sbjct: 340 SPSP-----AGGGSSPYSRRLPRSPSPYSRRRSPS 369
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 46.6 bits (109), Expect = 1e-04
Identities = 64/291 (21%), Positives = 114/291 (39%), Gaps = 38/291 (13%)
Query: 961 EDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKLRAQQRLIKNE 1020
E G DVSP P S S + R+ + P L +R YS+ + R++ RL +
Sbjct: 377 ERGGDVSPSPYSSSS---WRRSRSPYSPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSR-- 430
Query: 1021 KMECPDALAVESKPSRKSVCINPL-MSPKLALQVDADGFPVKPKSTEGMKGRKGKQVSEI 1079
S+ S+ + L + LA +++ + K ++ E + + + +E
Sbjct: 431 -----------SRSRHSSISPSTLTLKSSLAAELNKN---KKARAAEAARAAEAAKAAEA 476
Query: 1080 LPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK-------TPAAKRPAARDR 1132
AE +K + +S P N + AS+ H K +P++ D+
Sbjct: 477 TKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDK 536
Query: 1133 S-SQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQK-GA 1190
+ ++PP + + EN + I K+ K+ ++ K K S S+ + TKP GA
Sbjct: 537 AKTKPPLQVTKVENNL-IVDKATKKAVIVGKESKSAATKEESVSLKEK--TKPLTPSIGA 593
Query: 1191 GESSSRPQKATNRKQSSGKTRARPSTKTPES-----SAAQRKRKLKAKLDC 1236
E T+ P K +S S K++++ KL C
Sbjct: 594 KEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRC 644
Score = 32.0 bits (71), Expect = 3.8
Identities = 23/139 (16%), Positives = 57/139 (41%), Gaps = 5/139 (3%)
Query: 1105 PTVKASKEKHADGATKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKE 1164
P + ++ +G+ + RP RSS K +E++ + ++ ++ +
Sbjct: 181 PASSSGTQRRGEGSER-----RPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRH 235
Query: 1165 KENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAA 1224
+ +R + + + + ++K A +SS +R + ++R + S + P +
Sbjct: 236 SHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295
Query: 1225 QRKRKLKAKLDCSHSKRRR 1243
K + K + +RRR
Sbjct: 296 PPKAYREDKTEPKAYRRRR 314
Score = 30.8 bits (68), Expect = 8.4
Identities = 35/155 (22%), Positives = 60/155 (38%), Gaps = 15/155 (9%)
Query: 1061 KPKSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATK 1120
K +S G + +V++ + +RK +S S K KA + ++
Sbjct: 230 KSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHR-------SR 282
Query: 1121 TPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASET 1180
T ++K P + + +PPK + + K ++ S P ++ + R SQS+ S
Sbjct: 283 TKSSKEPPSAYK--EPPKAYREDKTEPKAYRRRRSLS-PLGGRDDSPVSHRASQSLRSRK 339
Query: 1181 LTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPS 1215
P AG SS + R S R PS
Sbjct: 340 SPSP-----AGGGSSPYSRRLPRSPSPYSRRRSPS 369
>gi|169166609 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 6 [Homo sapiens]
Length = 305
Score = 46.2 bits (108), Expect = 2e-04
Identities = 44/171 (25%), Positives = 77/171 (45%), Gaps = 23/171 (13%)
Query: 1060 VKPKSTEGMKGRKGKQVSEILPKAEVQSKRK-RTEGSSPPDSKNKGPTVKASKEKHADGA 1118
VK KS G+K K + +A +KRK R++ S SK+KG T ++S++
Sbjct: 6 VKKKSLLGVKENNKKSST----RAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDK 61
Query: 1119 TKTPAAKRPAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIAS 1178
T+ KR +A SS ++S S+G S +++ S+S +S
Sbjct: 62 TR----KRRSASSGSSSTRSRSS--------STSSSGSSTSTGSSSGSSSSSASSRSGSS 109
Query: 1179 ETLTKPAKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRK 1229
T + + SSS + +R++ + R+R +K P+ +RKR+
Sbjct: 110 ST------SRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRR 154
Score = 36.6 bits (83), Expect = 0.15
Identities = 37/162 (22%), Positives = 65/162 (40%), Gaps = 25/162 (15%)
Query: 1085 VQSKRKRTEGSSPPDSKNKGPTVKASKEKHAD-GATKTPAAKRPAARDRSSQPPKKTSLK 1143
V+ K++ +P +K K + + SK++ D GATK + K DR +K
Sbjct: 14 VKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEK-----DRGRDKTRK---- 64
Query: 1144 ENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKPAKQKGAGESSSRPQKATNR 1203
++SA +R +T+ S S T T + + +SSR ++
Sbjct: 65 -------RRSASSGSSSTRSRSSSTS-----SSGSSTSTGSSSGSSSSSASSRSGSSSTS 112
Query: 1204 KQSSGKTRA---RPSTKTPESSAAQRKRKLKAKLDCSHSKRR 1242
+ SS + + PS + ++ R + K D KRR
Sbjct: 113 RSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRR 154
Score = 35.4 bits (80), Expect = 0.34
Identities = 23/120 (19%), Positives = 52/120 (43%), Gaps = 9/120 (7%)
Query: 1063 KSTEGMKGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTP 1122
KS + K + + S + +++++R+ S ++++ + +S + G++
Sbjct: 38 KSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGS 97
Query: 1123 AAKRPAARDRSSQPPKKTSLKENKVKIP---------KKSAGKSCPPSRKEKENTNKRPS 1173
++ ++R SS + +S + ++S KS PP R EKE + PS
Sbjct: 98 SSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPS 157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,598,243
Number of Sequences: 37866
Number of extensions: 2998262
Number of successful extensions: 12583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 724
Number of HSP's that attempted gapping in prelim test: 9766
Number of HSP's gapped (non-prelim): 3005
length of query: 1247
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1133
effective length of database: 13,930,794
effective search space: 15783589602
effective search space used: 15783589602
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.