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Search of human proteins with 24308163
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308163 fem-1 homolog a [Homo sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308163 fem-1 homolog a [Homo sapiens] 1350 0.0
gi|17864094 feminization 1 homolog a [Homo sapiens] 585 e-167
gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Hom... 536 e-152
gi|7657265 fem-1 homolog b [Homo sapiens] 374 e-103
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 129 1e-29
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 111 2e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 111 2e-24
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 108 1e-23
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 108 1e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 108 2e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 108 2e-23
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 107 5e-23
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 107 5e-23
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 103 5e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 103 5e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 103 5e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 103 5e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 103 5e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 103 7e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 103 7e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 103 7e-22
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 102 9e-22
gi|155969701 espin-like [Homo sapiens] 102 1e-21
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 100 7e-21
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 98 2e-20
gi|110431370 espin [Homo sapiens] 96 8e-20
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 95 2e-19
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 94 5e-19
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens] 91 3e-18
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 91 3e-18
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 1350 bits (3493), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
Sbjct: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
Sbjct: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
Sbjct: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
Sbjct: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA 300
QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
Sbjct: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA 300
Query: 301 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL 360
LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL
Sbjct: 301 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL 360
Query: 361 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ 420
EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ
Sbjct: 361 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ 420
Query: 421 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ 480
QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ
Sbjct: 421 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ 480
Query: 481 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH 540
LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH
Sbjct: 481 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH 540
Query: 541 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL 600
MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL
Sbjct: 541 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL 600
Query: 601 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE 660
IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE
Sbjct: 601 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE 660
Query: 661 DLEAFIELH 669
DLEAFIELH
Sbjct: 661 DLEAFIELH 669
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 585 bits (1507), Expect = e-167
Identities = 341/681 (50%), Positives = 424/681 (62%), Gaps = 77/681 (11%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
MDL+TAV+NAARDGKL+LL KLL+ +S+EE+ L E G
Sbjct: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNG------------------- 41
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRR-------GASVNRTT 113
A PL A+ GHLD+V LL + G SVN
Sbjct: 42 -----------------------ATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDG 78
Query: 114 RT--NSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE 171
T + PL AA GHL+VV+ L+ H A + T L +C+ GH EI +YL+E
Sbjct: 79 ETIEGAPPLWAASAAGHLKVVQSLLN-HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVE 137
Query: 172 QGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNI 230
A + + G+T L G EI Q LL A + R G T L + +G +I
Sbjct: 138 HKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDI 197
Query: 231 VEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESC- 289
++ L+ E+ G P S+S N + +
Sbjct: 198 MKMLLMYCAKMEKDGYGMT---------------------PLLSASVTGHTNIVDFLTHH 236
Query: 290 CPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGG-EYLPKPEPPQLVLAY 348
TS+ + ALELLGAT+VDKKRDLLGALK+W++AM +R+ + KP P L++AY
Sbjct: 237 AQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAY 296
Query: 349 DYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFER 408
DY++EVN+ EELE LI DPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNF+R
Sbjct: 297 DYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKR 356
Query: 409 CIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVL 468
CI LWKYALDMQQSNL+PLSPMTASS LSFAELFS++LQDRA KG LGT + F DLMG+L
Sbjct: 357 CINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGIL 415
Query: 469 TKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKC 528
K V E+ERA++ + P D Q KAL+IILHL+ LLEKV CT Q+H K QT+YR LK
Sbjct: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
Query: 529 APRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
PRGKN F+PLH+AVDK+TT VGRYPV +FPSL V +L++CGAD + RD D+N+PLHIA
Sbjct: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
Query: 589 AQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALD 648
A NN P IMN LI++GAH DATN K+TA +LLDEK +A+ +QP N+ TLQCLAAR +
Sbjct: 536 ALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIV 595
Query: 649 KNKIPYKGFIPEDLEAFIELH 669
++I YKG IPE LE F+ LH
Sbjct: 596 NHRIYYKGHIPEKLETFVSLH 616
>gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Homo
sapiens]
Length = 287
Score = 536 bits (1381), Expect = e-152
Identities = 267/286 (93%), Positives = 273/286 (95%)
Query: 384 PSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFS 443
PSHPDTSY IRYRGAVYADSGN E IRLWKYALDMQQSNLEPL+PM+ASSFLSFAELFS
Sbjct: 2 PSHPDTSYCIRYRGAVYADSGNIECYIRLWKYALDMQQSNLEPLTPMSASSFLSFAELFS 61
Query: 444 YVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLY 503
YVLQD AAKGSLGTQIGFADLMGVLTK VREVE ALQL REP DSAQF KALAIILHLLY
Sbjct: 62 YVLQDPAAKGSLGTQIGFADLMGVLTKRVREVEWALQLLREPRDSAQFNKALAIILHLLY 121
Query: 504 LLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 563
LLEKVECTPSQEHLKHQT+YRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV
Sbjct: 122 LLEKVECTPSQEHLKHQTIYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 181
Query: 564 VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDE 623
VKVL DCGAD DSRDFDNNTPLHIAAQNNCPAI+NAL EAGAHMDATNAFKKTAYELL+E
Sbjct: 182 VKVLFDCGADRDSRDFDNNTPLHIAAQNNCPAIVNALTEAGAHMDATNAFKKTAYELLEE 241
Query: 624 KLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH 669
KLLARGTMQPFNYVTLQCLAA+ALDKNKIPYKGFIPEDLEAFIELH
Sbjct: 242 KLLARGTMQPFNYVTLQCLAAQALDKNKIPYKGFIPEDLEAFIELH 287
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 374 bits (960), Expect = e-103
Identities = 244/688 (35%), Positives = 370/688 (53%), Gaps = 93/688 (13%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGG----TPLLIAARYGHLDVVEYLVD 62
VY AA +GK+ L LL RS ++ L G V+ G TPL+IAAR GH VV L++
Sbjct: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
Query: 63 RCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRA 122
+ G+V FDG I+GA LW A+ AGH +VV+ L+ GA+VN TT TNSTPLRA
Sbjct: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
Query: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
ACFDG L++V+YLV E+ A++ +AN++ +TCLMI+ YKGH ++ RYLLEQ A N ++
Sbjct: 128 ACFDGRLDIVKYLV-ENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHC 186
Query: 183 GNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
G TALH AE+G ++I++ L+ +A + +G+GMTPL A+ + ++VE L+
Sbjct: 187 GATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL------- 239
Query: 243 QVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALE 302
S+ C R + +EALE
Sbjct: 240 ------------------------------------------SHADC---DRRSRIEALE 254
Query: 303 LLGATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL 360
LLGA++ + + D++ + AM R Q G+ + + E + AY E +EL
Sbjct: 255 LLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQEL 314
Query: 361 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ 420
E++ D D + M+ L++RERILG + D S+ I YRGAVYAD+ FE+CI+LW +AL ++
Sbjct: 315 ESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLR 374
Query: 421 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ 480
Q + T L FA++FS ++ L + D+ VL V E+E+++
Sbjct: 375 QKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCSVLEIEQSMN 423
Query: 481 LPREPGDS------AQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKN 534
+ D+ + L L+L+ + K +C+ + ++ +Y L+ PR +
Sbjct: 424 RVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTRE 483
Query: 535 GFTPLHMAVDKDT--TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
GFT LH+AV+ +T + V FP+ V K+LLDCGA+ ++ D + N+ LHI Q N
Sbjct: 484 GFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYN 543
Query: 593 CP--------AIMNALIEAGAHMDATNAFKKTAYELLD---EKLLARGTMQPFNYVTLQC 641
P +I+ +L+EAGAH D TN KT + ++L + M+ ++L+C
Sbjct: 544 RPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMK----MSLKC 599
Query: 642 LAARALDKNKIPYKGFIPEDLEAFIELH 669
LAARA+ N I Y+ IP LE F+ H
Sbjct: 600 LAARAVRANDINYQDQIPRTLEEFVGFH 627
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 129 bits (323), Expect = 1e-29
Identities = 87/239 (36%), Positives = 130/239 (54%), Gaps = 21/239 (8%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
RT + NAA G L ++ L+S + E+++ A G TPL +AAR GH VV L+
Sbjct: 546 RTLLANAAYSGSLDVVNLLVSRGADLEIED-----AHGHTPLTLAARQGHTKVVNCLIG- 599
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
CGA++ H D + G L +A+ GH +VV +LL G V+ + T LRAA
Sbjct: 600 CGANIN-----HTDQD---GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
+ GH ++V L+ +H A++ A+ G T L+ + Y GHREI +LL+ GA+VN G
Sbjct: 652 AWGGHEDIVLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710
Query: 184 NTALHDC-----AESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQ 236
TAL A G ++ LL+ A ++ D GMTPLL A+ GH ++V+ L++
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Score = 107 bits (267), Expect = 4e-23
Identities = 83/241 (34%), Positives = 118/241 (48%), Gaps = 11/241 (4%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
RTA+ AA G ++++ LL + +++ G A L + A GH VV L+DR
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA V+ H D + G PL A+ GH+DVV LL GA V+ T TPL AA
Sbjct: 738 -GAEVD-----HCDKD---GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
GH VV L+ A ++ + G T L I+ +G+ E+ R LL++G N R G
Sbjct: 789 ASMGHASVVNTLL-FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 184 NTALHDCAESGSLEILQLLLGCKARM-ERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
T LH A G I + L+ AR E D G P + AS GH + V+ L++ + +
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Query: 243 Q 243
Q
Sbjct: 908 Q 908
Score = 89.7 bits (221), Expect = 8e-18
Identities = 63/234 (26%), Positives = 110/234 (47%), Gaps = 18/234 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T ++ AA +G + + L+ G E+D G P ++A++ GH D V+ L++
Sbjct: 849 TPLHMAAFEGHRLICEALIEQGARTNEIDN------DGRIPFILASQEGHYDCVQILLEN 902
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
+ D +G L A+ GH D+V L GA VN L
Sbjct: 903 ---------KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
+ L + Y + E+ A++E ++ G T L +SC++GH E+ + L+ A VN +
Sbjct: 954 ALENQLTMAEYFL-ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012
Query: 184 NTALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQ 236
+AL A G ++++QLL+ A ++ G T L A+ GH ++V+ L++
Sbjct: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Score = 84.7 bits (208), Expect = 2e-16
Identities = 76/281 (27%), Positives = 127/281 (45%), Gaps = 35/281 (12%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D R A+ AA +G +++ L S + ++ + A G L I A L + EY +
Sbjct: 912 DGRNALRVAALEGHRDIVELLFSHGA-----DVNCKDADGRPTLYILALENQLTMAEYFL 966
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
+ GA+VEA + EG L + GH+++V+ L+ A VN + L+
Sbjct: 967 EN-GANVEASDA--------EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
+A + GH++VV+ L+ EH A ++ G T L I+ +GH ++ + LLE GA N
Sbjct: 1018 SAAWQGHVKVVQLLI-EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQ 1076
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTG-HT----------NI 230
G TA+ A++G +I++LL + YG + L S + HT +
Sbjct: 1077 FGRTAMRVAAKNGHSQIIKLL---------EKYGASSLNGCSPSPVHTMEQKPLQSLSSK 1127
Query: 231 VEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAP 271
V+ L + GG+ QP L + + P +P
Sbjct: 1128 VQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESP 1168
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 4/140 (2%)
Query: 97 DVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMI 156
+V++ L++ GA VN S +R A + +R L+ ++ A + + +G T L
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQAL--EREDSIRTLL-DNGASVNQCDSNGRTLLAN 551
Query: 157 SCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYG 215
+ Y G ++ L+ +GA + A G+T L A G +++ L+GC A + D G
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 216 MTPLLAASVTGHTNIVEYLI 235
T L +A+ GHT +V L+
Sbjct: 612 WTALRSAAWGGHTEVVSALL 631
Score = 43.5 bits (101), Expect = 6e-04
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 22/133 (16%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
K+G TPL +A + +V V +LL+ GAD D D + TPL AA
Sbjct: 746 KDGMTPLLVAAYEGHVDV-------------VDLLLEGGADVDHTDNNGRTPLLAAASMG 792
Query: 593 CPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKI 652
+++N L+ GA +D+ ++ +T + A+G N ++ L R LD+N
Sbjct: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIAS----AQG-----NVEVVRTLLDRGLDENHR 843
Query: 653 PYKGFIPEDLEAF 665
G+ P + AF
Sbjct: 844 DDAGWTPLHMAAF 856
Score = 38.5 bits (88), Expect = 0.020
Identities = 20/52 (38%), Positives = 32/52 (61%)
Query: 560 SLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATN 611
SL VV +L+ GAD + D +TPL +AA+ ++N LI GA+++ T+
Sbjct: 557 SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608
Score = 38.5 bits (88), Expect = 0.020
Identities = 20/49 (40%), Positives = 30/49 (61%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATN 611
VV +L+D GA+ D D D TPL +AA +++ L+E GA +D T+
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
Score = 38.5 bits (88), Expect = 0.020
Identities = 22/46 (47%), Positives = 27/46 (58%)
Query: 560 SLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
++ VV+ LLD G D + RD TPLH+AA I ALIE GA
Sbjct: 826 NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 871
Score = 34.7 bits (78), Expect = 0.29
Identities = 18/55 (32%), Positives = 32/55 (58%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTA 617
+V++L GAD + +D D L+I A N + +E GA+++A++A +TA
Sbjct: 928 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
Score = 33.9 bits (76), Expect = 0.50
Identities = 18/45 (40%), Positives = 27/45 (60%)
Query: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
+ VV+VLL+ GADP+ D T + +AA+N I+ L + GA
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 30.4 bits (67), Expect = 5.5
Identities = 26/102 (25%), Positives = 40/102 (39%), Gaps = 20/102 (19%)
Query: 531 RGKNGFTPLHMAV-----------------DKDTTNVGRYP---VGRFPSLHVVKVLLDC 570
R G+TPLHMA + N GR P + V++LL+
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNA 612
++ D R +D L +AA I+ L GA ++ +A
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Score = 30.0 bits (66), Expect = 7.2
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 5/51 (9%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIA-----AQNNCPAIMNALIEAGAHMD 608
+V+ LLD GA+ + D D T L +A A ++++ LI+ GA +D
Sbjct: 692 IVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 111 bits (278), Expect = 2e-24
Identities = 80/238 (33%), Positives = 129/238 (54%), Gaps = 20/238 (8%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 487
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GAS+E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 488 ER-GASLEEVND--------EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G LEV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 539 TLACCGGFLEVADFLI-KAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNIVEYLIQE 237
A G+TAL E+G ++ +LL A +E + G TPL+ A+ GH V++LI +
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Score = 107 bits (267), Expect = 4e-23
Identities = 78/237 (32%), Positives = 116/237 (48%), Gaps = 16/237 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E + G++ TPL+ AA GH+ +V+ L+ A V
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAH-KADVN 328
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A S G L A A G++DVV+ LL GAS+ TPL A GH+
Sbjct: 329 AQSST--------GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHD 189
EV R L+ +N + L ++CYKGH E+ R+LLE GA ++ + +TAL +
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 190 CAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGASLEEV 496
Score = 102 bits (253), Expect = 1e-21
Identities = 82/234 (35%), Positives = 121/234 (51%), Gaps = 21/234 (8%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T + AAR+G +++ LL G + E T E A L +A G L+V ++L+ +
Sbjct: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETA-----LTLACCGGFLEVADFLI-K 555
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +E G S PL A+ GHL++V+ LL GA+V+ TT T T L A
Sbjct: 556 AGADIELGCST-----------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C +GH +V L+ + ADLE + G T LM + GH ++L+ +GA VNR +A
Sbjct: 605 CENGHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 184 N-TALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYLI 235
+ T L G L +++LLL A R G T L+ A+ GHT++V YL+
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 97.1 bits (240), Expect = 5e-20
Identities = 77/231 (33%), Positives = 117/231 (50%), Gaps = 15/231 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
AA G + +++ LL+ + E++ TG G +PL++AA GH V+ L+D
Sbjct: 1190 AASGGYVNIIKILLNAGA--EINSRTGSKLGI-SPLMLAAMNGHTAAVKLLLDM------ 1240
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
G ++ ET L A G +VV LL R A+V +T TPL A G+
Sbjct: 1241 -GSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1298
Query: 130 EVVRYLVGEHQADLEV--ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
EV R L+ + AD+ T L I+ KGH + L+ +GA ++ R+ KGNT L
Sbjct: 1299 EVGRVLL-DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPL 1357
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
A G L+++QLL+ A ++ D +TPL+AA GH +V YL++E
Sbjct: 1358 WLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 95.1 bits (235), Expect = 2e-19
Identities = 76/237 (32%), Positives = 118/237 (49%), Gaps = 18/237 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
TA+ A G +L+Q LL G S E D+ G TPL++AA GH+ VVE L+D
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKK------GFTPLILAATAGHVGVVEILLDN 1138
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +EA D PL A + G +VV LL RGA+ ++ TPL A
Sbjct: 1139 -GADIEAQSERTKD-------TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190
Query: 124 CFDGHLEVVRYLVGE-HQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRR-SA 181
G++ +++ L+ + + ++ G + LM++ GH + LL+ G+ +N +
Sbjct: 1191 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 1250
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
NTAL G E++ LLL KA +E R G+TPL+ A+ G+ + L+ +
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/248 (28%), Positives = 116/248 (46%), Gaps = 18/248 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
+A+ A G L++++ LL + +E T E+ T L+ A GH++V L+D
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQE--HKTDEMH---TALMEACMDGHVEVARLLLD-- 455
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
+G V+ ++ E PL A+ GH+++ L+ RGAS+ TPL A
Sbjct: 456 -----SGAQVNMPADSFES--PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+G+ T L ++C G E+A +L++ GA + +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--- 565
Query: 185 TALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T L + A+ G LE+++ LL A + G T L A GHT++ + L+Q E
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 244 VAGGEAQP 251
+ G P
Sbjct: 626 ESEGGRTP 633
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/168 (35%), Positives = 85/168 (50%), Gaps = 16/168 (9%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T + AA++G L+L++ LL+ + TG+ A L A GH DV + L+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA-----LTYACENGHTDVADVLL--- 617
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS-TPLRAA 123
+AG + + E G PL A+ AGH+ V+ L+ +GA+VNRTT N T L A
Sbjct: 618 ----QAGADLEHESEG--GRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE 171
C GHL VV L+ H AD + G T L+ + GH + YLL+
Sbjct: 672 CAGGHLAVVELLLA-HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 76.3 bits (186), Expect = 9e-14
Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 3/153 (1%)
Query: 90 ASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRH 149
A + G ++ VR LL G SVN T + L AC G+ E+ + L+ H A++E
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH-ANVEDRGIK 299
Query: 150 GH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKAR 208
G T LM + GH +I + LL A VN +S+ GNTAL G ++++++LL A
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
Query: 209 ME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
+E + G TPL+ A GH + L++ G
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLLENGAG 392
Score = 70.1 bits (170), Expect = 6e-12
Identities = 54/161 (33%), Positives = 74/161 (45%), Gaps = 33/161 (20%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ A G+ +++ LL ++ E TG TPL+ AA G+ +V L+D+
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGL-----TPLMEAASGGYAEVGRVLLDK- 1307
Query: 65 GASVEA---------------------------GGSVHFDGETIEGAPPLWAASAAGHLD 97
GA V A G H D +G PLW A+ GHLD
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE 138
VV+ L++ GA V+ TPL AA GH++VVRYLV E
Sbjct: 1368 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 60.1 bits (144), Expect = 7e-09
Identities = 41/127 (32%), Positives = 67/127 (52%), Gaps = 3/127 (2%)
Query: 111 RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL 170
+T + T L AC GH E+V+ L+ E A +E ++ G T L+++ GH + LL
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLL-ERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 171 EQGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHT 228
+ GA + +S + +T L G E+++LLL A E R+ TPL A+ G+
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196
Query: 229 NIVEYLI 235
NI++ L+
Sbjct: 1197 NIIKILL 1203
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 142 DLEVANRHGH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQ 200
D++ H T L ++C GH E+ + LLE+GA + R KG T L A +G + +++
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 201 LLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
+LL G + + TPL A G +VE L+ +E
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177
Score = 39.3 bits (90), Expect = 0.012
Identities = 48/221 (21%), Positives = 84/221 (38%), Gaps = 33/221 (14%)
Query: 420 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGS-LGTQIGFADLMGVLTKG-VREVER 477
+ N+ +P++ ++ + + +L A S G+++G + LM G V+
Sbjct: 1177 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 1236
Query: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFT 537
L + + + + A+ L C + + + R R K G T
Sbjct: 1237 LLDMGSDINAQIETNRNTALTL---------ACFQGRTEVVSLLLDRKANVEHRAKTGLT 1287
Query: 538 PLHMAVDKDTTNVGRY-------------PVGRFPSLHVV---------KVLLDCGADPD 575
PL A VGR P R +L + ++L+ GA D
Sbjct: 1288 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1347
Query: 576 SRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
R+ NTPL +AA ++ L++AGA +DA + K T
Sbjct: 1348 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1388
Score = 38.1 bits (87), Expect = 0.026
Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 14/112 (12%)
Query: 510 CTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLD 569
C E L + R R K GFTPL +A +VG VV++LLD
Sbjct: 1091 CAGGHEELVQTLLERGASIEHRDKKGFTPLILAA--TAGHVG-----------VVEILLD 1137
Query: 570 CGADPDSR-DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
GAD +++ + +TPL +A ++ L+ GA+ + N T L
Sbjct: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Score = 33.5 bits (75), Expect = 0.65
Identities = 21/59 (35%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
VVKVLL+ GA + + + +TPL A + L+E GA ++ +N FK++A L
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL 407
Score = 29.6 bits (65), Expect = 9.4
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 13/98 (13%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
R K G TPL +A N G L VV++L+ GAD D+ D TPL A +
Sbjct: 1349 RNKKGNTPLWLAA-----NGGH--------LDVVQLLVQAGADVDAADNRKITPLMAAFR 1395
Query: 591 NNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLAR 628
++ L++ + + + + D+++L +
Sbjct: 1396 KGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKK 1433
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 111 bits (278), Expect = 2e-24
Identities = 80/238 (33%), Positives = 129/238 (54%), Gaps = 20/238 (8%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 487
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GAS+E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 488 ER-GASLEEVND--------EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G LEV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 539 TLACCGGFLEVADFLI-KAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNIVEYLIQE 237
A G+TAL E+G ++ +LL A +E + G TPL+ A+ GH V++LI +
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Score = 107 bits (267), Expect = 4e-23
Identities = 78/237 (32%), Positives = 116/237 (48%), Gaps = 16/237 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E + G++ TPL+ AA GH+ +V+ L+ A V
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDI----TPLMAAANGGHVKIVKLLLAH-KADVN 328
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A S G L A A G++DVV+ LL GAS+ TPL A GH+
Sbjct: 329 AQSST--------GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHD 189
EV R L+ +N + L ++CYKGH E+ R+LLE GA ++ + +TAL +
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 190 CAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGASLEEV 496
Score = 102 bits (253), Expect = 1e-21
Identities = 82/234 (35%), Positives = 121/234 (51%), Gaps = 21/234 (8%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T + AAR+G +++ LL G + E T E A L +A G L+V ++L+ +
Sbjct: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETA-----LTLACCGGFLEVADFLI-K 555
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +E G S PL A+ GHL++V+ LL GA+V+ TT T T L A
Sbjct: 556 AGADIELGCST-----------PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C +GH +V L+ + ADLE + G T LM + GH ++L+ +GA VNR +A
Sbjct: 605 CENGHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 184 N-TALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYLI 235
+ T L G L +++LLL A R G T L+ A+ GHT++V YL+
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 97.1 bits (240), Expect = 5e-20
Identities = 77/231 (33%), Positives = 117/231 (50%), Gaps = 15/231 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
AA G + +++ LL+ + E++ TG G +PL++AA GH V+ L+D
Sbjct: 939 AASGGYVNIIKILLNAGA--EINSRTGSKLGI-SPLMLAAMNGHTAAVKLLLDM------ 989
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
G ++ ET L A G +VV LL R A+V +T TPL A G+
Sbjct: 990 -GSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1047
Query: 130 EVVRYLVGEHQADLEV--ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
EV R L+ + AD+ T L I+ KGH + L+ +GA ++ R+ KGNT L
Sbjct: 1048 EVGRVLL-DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPL 1106
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
A G L+++QLL+ A ++ D +TPL+AA GH +V YL++E
Sbjct: 1107 WLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 95.1 bits (235), Expect = 2e-19
Identities = 76/237 (32%), Positives = 118/237 (49%), Gaps = 18/237 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
TA+ A G +L+Q LL G S E D+ G TPL++AA GH+ VVE L+D
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKK------GFTPLILAATAGHVGVVEILLDN 887
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +EA D PL A + G +VV LL RGA+ ++ TPL A
Sbjct: 888 -GADIEAQSERTKD-------TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 939
Query: 124 CFDGHLEVVRYLVGE-HQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRR-SA 181
G++ +++ L+ + + ++ G + LM++ GH + LL+ G+ +N +
Sbjct: 940 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 999
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
NTAL G E++ LLL KA +E R G+TPL+ A+ G+ + L+ +
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1056
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/248 (28%), Positives = 116/248 (46%), Gaps = 18/248 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
+A+ A G L++++ LL + +E T E+ T L+ A GH++V L+D
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQE--HKTDEMH---TALMEACMDGHVEVARLLLD-- 455
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
+G V+ ++ E PL A+ GH+++ L+ RGAS+ TPL A
Sbjct: 456 -----SGAQVNMPADSFES--PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+G+ T L ++C G E+A +L++ GA + +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--- 565
Query: 185 TALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T L + A+ G LE+++ LL A + G T L A GHT++ + L+Q E
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 244 VAGGEAQP 251
+ G P
Sbjct: 626 ESEGGRTP 633
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/168 (35%), Positives = 85/168 (50%), Gaps = 16/168 (9%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T + AA++G L+L++ LL+ + TG+ A L A GH DV + L+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA-----LTYACENGHTDVADVLL--- 617
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS-TPLRAA 123
+AG + + E G PL A+ AGH+ V+ L+ +GA+VNRTT N T L A
Sbjct: 618 ----QAGADLEHESEG--GRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE 171
C GHL VV L+ H AD + G T L+ + GH + YLL+
Sbjct: 672 CAGGHLAVVELLLA-HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 76.3 bits (186), Expect = 9e-14
Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 3/153 (1%)
Query: 90 ASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRH 149
A + G ++ VR LL G SVN T + L AC G+ E+ + L+ H A++E
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH-ANVEDRGIK 299
Query: 150 GH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKAR 208
G T LM + GH +I + LL A VN +S+ GNTAL G ++++++LL A
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
Query: 209 ME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
+E + G TPL+ A GH + L++ G
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLLENGAG 392
Score = 70.1 bits (170), Expect = 6e-12
Identities = 54/161 (33%), Positives = 74/161 (45%), Gaps = 33/161 (20%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ A G+ +++ LL ++ E TG TPL+ AA G+ +V L+D+
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGL-----TPLMEAASGGYAEVGRVLLDK- 1056
Query: 65 GASVEA---------------------------GGSVHFDGETIEGAPPLWAASAAGHLD 97
GA V A G H D +G PLW A+ GHLD
Sbjct: 1057 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1116
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE 138
VV+ L++ GA V+ TPL AA GH++VVRYLV E
Sbjct: 1117 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 60.1 bits (144), Expect = 7e-09
Identities = 41/127 (32%), Positives = 67/127 (52%), Gaps = 3/127 (2%)
Query: 111 RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL 170
+T + T L AC GH E+V+ L+ E A +E ++ G T L+++ GH + LL
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLL-ERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 171 EQGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHT 228
+ GA + +S + +T L G E+++LLL A E R+ TPL A+ G+
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 945
Query: 229 NIVEYLI 235
NI++ L+
Sbjct: 946 NIIKILL 952
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 142 DLEVANRHGH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQ 200
D++ H T L ++C GH E+ + LLE+GA + R KG T L A +G + +++
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 201 LLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
+LL G + + TPL A G +VE L+ +E
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926
Score = 39.3 bits (90), Expect = 0.012
Identities = 48/221 (21%), Positives = 84/221 (38%), Gaps = 33/221 (14%)
Query: 420 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGS-LGTQIGFADLMGVLTKG-VREVER 477
+ N+ +P++ ++ + + +L A S G+++G + LM G V+
Sbjct: 926 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 985
Query: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFT 537
L + + + + A+ L C + + + R R K G T
Sbjct: 986 LLDMGSDINAQIETNRNTALTL---------ACFQGRTEVVSLLLDRKANVEHRAKTGLT 1036
Query: 538 PLHMAVDKDTTNVGRY-------------PVGRFPSLHVV---------KVLLDCGADPD 575
PL A VGR P R +L + ++L+ GA D
Sbjct: 1037 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1096
Query: 576 SRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
R+ NTPL +AA ++ L++AGA +DA + K T
Sbjct: 1097 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
Score = 38.1 bits (87), Expect = 0.026
Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 14/112 (12%)
Query: 510 CTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLD 569
C E L + R R K GFTPL +A +VG VV++LLD
Sbjct: 840 CAGGHEELVQTLLERGASIEHRDKKGFTPLILAA--TAGHVG-----------VVEILLD 886
Query: 570 CGADPDSR-DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
GAD +++ + +TPL +A ++ L+ GA+ + N T L
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Score = 33.5 bits (75), Expect = 0.65
Identities = 21/59 (35%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
VVKVLL+ GA + + + +TPL A + L+E GA ++ +N FK++A L
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL 407
Score = 29.6 bits (65), Expect = 9.4
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 13/98 (13%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
R K G TPL +A N G L VV++L+ GAD D+ D TPL A +
Sbjct: 1098 RNKKGNTPLWLAA-----NGGH--------LDVVQLLVQAGADVDAADNRKITPLMAAFR 1144
Query: 591 NNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLAR 628
++ L++ + + + + D+++L +
Sbjct: 1145 KGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKK 1182
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 108 bits (271), Expect = 1e-23
Identities = 79/235 (33%), Positives = 122/235 (51%), Gaps = 17/235 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T + A+ G L +++ LL + ++ + A G T L A G +D+V+ L++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDA-----DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPLRAA 123
GA++E G PL A++AGH++V R LL GA +N + + L A
Sbjct: 328 GANIEDHNE--------NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C+ GHL++VR+L+ E AD E HT LM +C GH E+AR LL+ GAQVN +
Sbjct: 380 CYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
Query: 184 NTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQE 237
+ L A G +E+ LL+ A +E + G TPL+ A+ GH +V L+ +
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 103 bits (257), Expect = 5e-22
Identities = 73/238 (30%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E G++ TPL+ A+ G+LD+V+ L+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLH------ 294
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
+ ++ G L A A G +D+V+ LL GA++ TPL A GH+
Sbjct: 295 ---DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 130 EVVRYLVGEHQADLEV-ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALH 188
EV R L+ +H A + +N + L ++CYKGH ++ R+LLE GA ++ + +TAL
Sbjct: 352 EVARVLL-DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 410
Query: 189 DCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
+ G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 411 EACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEV 467
Score = 93.6 bits (231), Expect = 5e-19
Identities = 86/265 (32%), Positives = 119/265 (44%), Gaps = 50/265 (18%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
TA+ A G + +++ LL+ G + E+ +E G TPL+ AA GH++V L+D
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNE------NGHTPLMEAASAGHVEVARVLLDH 360
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
AG + H E E A L A GHLD+VR LL GA T T L A
Sbjct: 361 -----GAGINTH-SNEFKESA--LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412
Query: 124 CFDGHLEVVRYLVG--------------------------------EHQADLEVANRHGH 151
C DGH+EV R L+ E A+LE N G+
Sbjct: 413 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472
Query: 152 TCLMISCYKGHREIARYLLEQGAQVNRRSAKGN-TALHDCAESGSLEILQLLLGCKARME 210
T LM + +GH E+ LL QGA +N ++ + TAL G E+ L+ A +E
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
Query: 211 RDGYGMTPLLAASVTGHTNIVEYLI 235
TPL+ AS GH +V+YL+
Sbjct: 533 LGC--STPLMEASQEGHLELVKYLL 555
Score = 92.8 bits (229), Expect = 9e-19
Identities = 67/211 (31%), Positives = 113/211 (53%), Gaps = 19/211 (9%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GA++E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 459 ER-GANLEEVND--------EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G EV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 510 TLACCGGFSEVADFLI-KAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMER 211
A G+TAL E+G ++ +LL A +++
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGADLDK 596
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 90 ASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRH 149
A + G ++ VR LL G SVN T + L AC G+ E+ + L+ H + N+
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 GHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM 209
T LM + G+ +I + LL A VN +SA GNTAL G ++I+++LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 210 E-RDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
E + G TPL+ A+ GH + L+ G
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Score = 53.9 bits (128), Expect = 5e-07
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 5/152 (3%)
Query: 90 ASAAGHLDVVRSLLRRGASVN--RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVAN 147
+S + LD + L R + N + ++ L AC DG + VR L+ E ++ +
Sbjct: 177 SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHT 235
Query: 148 RHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN-TALHDCAESGSLEILQLLLGCK 206
G + L ++C G+ E+A+ LL A V R KG+ T L + G L+I++LLL
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 207 ARM-ERDGYGMTPLLAASVTGHTNIVEYLIQE 237
A + + G T L A G +IV+ L+ E
Sbjct: 296 ADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Score = 32.7 bits (73), Expect = 1.1
Identities = 20/59 (33%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
+VKVLL+ GA+ + + + +TPL AA + L++ GA ++ +N FK++A L
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Score = 30.4 bits (67), Expect = 5.5
Identities = 17/54 (31%), Positives = 27/54 (50%)
Query: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFK 614
L +VK LL GA+ + +T L A +N + + L++AGA +D K
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 108 bits (271), Expect = 1e-23
Identities = 79/235 (33%), Positives = 122/235 (51%), Gaps = 17/235 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T + A+ G L +++ LL + ++ + A G T L A G +D+V+ L++
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDA-----DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 316
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPLRAA 123
GA++E G PL A++AGH++V R LL GA +N + + L A
Sbjct: 317 GANIEDHNE--------NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 368
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C+ GHL++VR+L+ E AD E HT LM +C GH E+AR LL+ GAQVN +
Sbjct: 369 CYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
Query: 184 NTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQE 237
+ L A G +E+ LL+ A +E + G TPL+ A+ GH +V L+ +
Sbjct: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Score = 103 bits (257), Expect = 5e-22
Identities = 73/238 (30%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E G++ TPL+ A+ G+LD+V+ L+
Sbjct: 234 ACSAGYYELAQVLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLH------ 283
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
+ ++ G L A A G +D+V+ LL GA++ TPL A GH+
Sbjct: 284 ---DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
Query: 130 EVVRYLVGEHQADLEV-ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALH 188
EV R L+ +H A + +N + L ++CYKGH ++ R+LLE GA ++ + +TAL
Sbjct: 341 EVARVLL-DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 399
Query: 189 DCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
+ G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 400 EACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEV 456
Score = 93.6 bits (231), Expect = 5e-19
Identities = 86/265 (32%), Positives = 119/265 (44%), Gaps = 50/265 (18%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
TA+ A G + +++ LL+ G + E+ +E G TPL+ AA GH++V L+D
Sbjct: 296 TALTYACAGGFVDIVKVLLNEGANIEDHNE------NGHTPLMEAASAGHVEVARVLLDH 349
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
AG + H E E A L A GHLD+VR LL GA T T L A
Sbjct: 350 -----GAGINTH-SNEFKESA--LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
Query: 124 CFDGHLEVVRYLVG--------------------------------EHQADLEVANRHGH 151
C DGH+EV R L+ E A+LE N G+
Sbjct: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
Query: 152 TCLMISCYKGHREIARYLLEQGAQVNRRSAKGN-TALHDCAESGSLEILQLLLGCKARME 210
T LM + +GH E+ LL QGA +N ++ + TAL G E+ L+ A +E
Sbjct: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
Query: 211 RDGYGMTPLLAASVTGHTNIVEYLI 235
TPL+ AS GH +V+YL+
Sbjct: 522 LGC--STPLMEASQEGHLELVKYLL 544
Score = 92.8 bits (229), Expect = 9e-19
Identities = 67/211 (31%), Positives = 113/211 (53%), Gaps = 19/211 (9%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 393 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 447
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GA++E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 448 ER-GANLEEVND--------EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G EV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 499 TLACCGGFSEVADFLI-KAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMER 211
A G+TAL E+G ++ +LL A +++
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQAGADLDK 585
Score = 78.6 bits (192), Expect = 2e-14
Identities = 62/204 (30%), Positives = 91/204 (44%), Gaps = 8/204 (3%)
Query: 45 LLIAARYGHLDVVEYLVDR--CGASVEAGGSVHFDGETIEGAPPLWAASAA-----GHLD 97
LL AA + +V+ L C A E A + S A G ++
Sbjct: 149 LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVN 208
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
VR LL G SVN T + L AC G+ E+ + L+ H + N+ T LM +
Sbjct: 209 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAA 268
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGM 216
G+ +I + LL A VN +SA GNTAL G ++I+++LL A +E + G
Sbjct: 269 SSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGH 328
Query: 217 TPLLAASVTGHTNIVEYLIQEQPG 240
TPL+ A+ GH + L+ G
Sbjct: 329 TPLMEAASAGHVEVARVLLDHGAG 352
Score = 32.7 bits (73), Expect = 1.1
Identities = 20/59 (33%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
+VKVLL+ GA+ + + + +TPL AA + L++ GA ++ +N FK++A L
Sbjct: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 367
Score = 30.4 bits (67), Expect = 5.5
Identities = 17/54 (31%), Positives = 27/54 (50%)
Query: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFK 614
L +VK LL GA+ + +T L A +N + + L++AGA +D K
Sbjct: 537 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 108 bits (269), Expect = 2e-23
Identities = 78/238 (32%), Positives = 128/238 (53%), Gaps = 20/238 (8%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GA++E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 459 ER-GANLEEVND--------EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G EV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 510 TLACCGGFSEVADFLI-KAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNIVEYLIQE 237
A G+TAL E+G ++ +LL A +E + G TPL+ A+ GH V++LI +
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Score = 104 bits (259), Expect = 3e-22
Identities = 91/279 (32%), Positives = 132/279 (47%), Gaps = 22/279 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T + AAR+G +++ LL+ G + E T E A L +A G +V ++L+ +
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-----LTLACCGGFSEVADFLI-K 526
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +E G S PL AS GHL++V+ LL GA+V+ TT T T L A
Sbjct: 527 AGADIELGCST-----------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C +GH +V L+ + ADLE + G T LM + GH ++L+ +GA VNR +A
Sbjct: 576 CENGHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 184 N-TALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
+ T + G L +++LLL A R G T L+ A+ GHTN+V YL+ + P
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL-DYPNN 693
Query: 242 EQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEP 280
LP SQ P P+EP
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEP 732
Score = 103 bits (257), Expect = 5e-22
Identities = 73/238 (30%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E G++ TPL+ A+ G+LD+V+ L+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLH------ 294
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
+ ++ G L A A G +D+V+ LL GA++ TPL A GH+
Sbjct: 295 ---DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 130 EVVRYLVGEHQADLEV-ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALH 188
EV R L+ +H A + +N + L ++CYKGH ++ R+LLE GA ++ + +TAL
Sbjct: 352 EVARVLL-DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 410
Query: 189 DCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
+ G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 411 EACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEV 467
Score = 95.9 bits (237), Expect = 1e-19
Identities = 74/231 (32%), Positives = 118/231 (51%), Gaps = 15/231 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
AA G + +++ LL+ + E++ TG G +PL++AA GH+ V+ L+D
Sbjct: 1162 AASGGYVNIIKILLNAGA--EINSRTGSKLGI-SPLMLAAMNGHVPAVKLLLDM------ 1212
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
G ++ ET L A G +VV LL R A+V +T TPL A G+
Sbjct: 1213 -GSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 130 EVVRYLVGEHQADLEV--ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
EV R L+ + AD+ T L I+ KGH + L+ +GA ++ R+ KGNT L
Sbjct: 1271 EVGRVLL-DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
+ G +++QLL+ A ++ D +TPL++A GH +V+YL++E
Sbjct: 1330 WLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 89.0 bits (219), Expect = 1e-17
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 11/200 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL++AA GH+ VVE L+D+ GG + E + P L A + G +VV
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDK-------GGDIEAQSERTKDTP-LSLACSGGRQEVVD 1139
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE-HQADLEVANRHGHTCLMISCY 159
LL RGA+ ++ TPL A G++ +++ L+ + + ++ G + LM++
Sbjct: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
Query: 160 KGHREIARYLLEQGAQVNRR-SAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMT 217
GH + LL+ G+ +N + NTAL G E++ LLL KA +E R G+T
Sbjct: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
Query: 218 PLLAASVTGHTNIVEYLIQE 237
PL+ A+ G+ + L+ +
Sbjct: 1260 PLMEAASGGYAEVGRVLLDK 1279
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 90 ASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRH 149
A + G ++ VR LL G SVN T + L AC G+ E+ + L+ H + N+
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 GHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM 209
T LM + G+ +I + LL A VN +SA GNTAL G ++I+++LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 210 E-RDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
E + G TPL+ A+ GH + L+ G
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Score = 69.7 bits (169), Expect = 8e-12
Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 5/153 (3%)
Query: 87 LWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEV- 145
L A A GH ++V L+ R A + + TPL A GH+ VV L+ + D+E
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL-DKGGDIEAQ 1117
Query: 146 ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGC 205
+ R T L ++C G +E+ LL +GA R+ T L A G + I+++LL
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 206 KARM-ERDG--YGMTPLLAASVTGHTNIVEYLI 235
A + R G G++PL+ A++ GH V+ L+
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Score = 66.6 bits (161), Expect = 7e-11
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 17/146 (11%)
Query: 43 TPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSL 102
T L IAA GH E L+ R H D +G PLW AS GH DVV+ L
Sbjct: 1294 TALTIAADKGHYKFCELLIHR---------GAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 103 LRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE---HQADLEVANRHGHTC----LM 155
++ GA V+ TPL +A GH++VV+YLV E +D+E R+ T L+
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIE-CMRYIATITDKELL 1403
Query: 156 ISCYKGHREIARYLLEQGAQVNRRSA 181
C++ I + +Q A+ N+ ++
Sbjct: 1404 KKCHQCVETIVKAKDQQAAEANKNAS 1429
Score = 56.6 bits (135), Expect = 7e-08
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 3/126 (2%)
Query: 112 TTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE 171
T + T L AC GH E+V L+ A +E ++ G T L+++ GH + LL+
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIA-RDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 172 QGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTN 229
+G + +S + +T L G E++ LLL A E R+ TPL A+ G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 230 IVEYLI 235
I++ L+
Sbjct: 1170 IIKILL 1175
Score = 53.9 bits (128), Expect = 5e-07
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 5/152 (3%)
Query: 90 ASAAGHLDVVRSLLRRGASVN--RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVAN 147
+S + LD + L R + N + ++ L AC DG + VR L+ E ++ +
Sbjct: 177 SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHT 235
Query: 148 RHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN-TALHDCAESGSLEILQLLLGCK 206
G + L ++C G+ E+A+ LL A V R KG+ T L + G L+I++LLL
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 207 ARM-ERDGYGMTPLLAASVTGHTNIVEYLIQE 237
A + + G T L A G +IV+ L+ E
Sbjct: 296 ADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Score = 43.9 bits (102), Expect = 5e-04
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 3/104 (2%)
Query: 142 DLEVANRHGH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQ 200
D++ H T L ++C GH E+ L+ + A++ R KG T L A +G + +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 201 LLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
+LL G + + TPL A G +V+ L+ +E
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE 1149
Score = 38.9 bits (89), Expect = 0.016
Identities = 32/112 (28%), Positives = 49/112 (43%), Gaps = 14/112 (12%)
Query: 510 CTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLD 569
C E L + R K R K GFTPL +A +VG VV++LLD
Sbjct: 1063 CAGGHEELVSVLIARDAKIEHRDKKGFTPLILAA--TAGHVG-----------VVEILLD 1109
Query: 570 CGADPDSR-DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
G D +++ + +TPL +A +++ L+ GA+ + N T L
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 38.9 bits (89), Expect = 0.016
Identities = 48/221 (21%), Positives = 85/221 (38%), Gaps = 33/221 (14%)
Query: 420 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGS-LGTQIGFADLMGVLTKG-VREVER 477
+ N+ +P++ ++ + + +L A S G+++G + LM G V V+
Sbjct: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
Query: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFT 537
L + + + + A+ L C + + + R R K G T
Sbjct: 1209 LLDMGSDINAQIETNRNTALTL---------ACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
Query: 538 PLHMAVDKDTTNVGRY-------------PVGRFPSLHVV---------KVLLDCGADPD 575
PL A VGR P R +L + ++L+ GA D
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
Query: 576 SRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
R+ NTPL +A+ ++ L++AGA +DA + K T
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKIT 1360
Score = 32.7 bits (73), Expect = 1.1
Identities = 20/59 (33%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
+VKVLL+ GA+ + + + +TPL AA + L++ GA ++ +N FK++A L
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Score = 32.0 bits (71), Expect = 1.9
Identities = 48/180 (26%), Positives = 72/180 (40%), Gaps = 35/180 (19%)
Query: 430 MTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL-----QLPRE 484
+T + F AE+ S +L DR A + G LM + G EV R L +
Sbjct: 1228 LTLACFQGRAEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 485 PGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK--HQTVYRLLKCAPRGKNGFTPLHMA 542
P S++ T AL I + H K ++R R K G TPL +A
Sbjct: 1287 PVPSSRDT-ALTI-------------AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 543 VDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIE 602
+N G + V V++L+ GAD D+ D TPL A + ++ L++
Sbjct: 1333 -----SNGGHFDV--------VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 108 bits (269), Expect = 2e-23
Identities = 78/238 (32%), Positives = 128/238 (53%), Gaps = 20/238 (8%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
++ TA+ A DG +++ + LL ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNSTPL 120
+R GA++E EG PL A+ GH ++V LL +GA++N +T T T L
Sbjct: 459 ER-GANLEEVND--------EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
AC G EV +L+ + AD+E+ T LM + +GH E+ +YLL GA V+ +
Sbjct: 510 TLACCGGFSEVADFLI-KAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNIVEYLIQE 237
A G+TAL E+G ++ +LL A +E + G TPL+ A+ GH V++LI +
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Score = 104 bits (259), Expect = 3e-22
Identities = 91/279 (32%), Positives = 132/279 (47%), Gaps = 22/279 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T + AAR+G +++ LL+ G + E T E A L +A G +V ++L+ +
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-----LTLACCGGFSEVADFLI-K 526
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA +E G S PL AS GHL++V+ LL GA+V+ TT T T L A
Sbjct: 527 AGADIELGCST-----------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
C +GH +V L+ + ADLE + G T LM + GH ++L+ +GA VNR +A
Sbjct: 576 CENGHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 184 N-TALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
+ T + G L +++LLL A R G T L+ A+ GHTN+V YL+ + P
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL-DYPNN 693
Query: 242 EQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEP 280
LP SQ P P+EP
Sbjct: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEP 732
Score = 103 bits (257), Expect = 5e-22
Identities = 73/238 (30%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A G +L Q LL+ + E G++ TPL+ A+ G+LD+V+ L+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLH------ 294
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
+ ++ G L A A G +D+V+ LL GA++ TPL A GH+
Sbjct: 295 ---DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 130 EVVRYLVGEHQADLEV-ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALH 188
EV R L+ +H A + +N + L ++CYKGH ++ R+LLE GA ++ + +TAL
Sbjct: 352 EVARVLL-DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 410
Query: 189 DCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV 244
+ G +E+ +LLL G + M D + +PL A+ GH + LI+ E+V
Sbjct: 411 EACMDGHVEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEV 467
Score = 95.9 bits (237), Expect = 1e-19
Identities = 74/231 (32%), Positives = 118/231 (51%), Gaps = 15/231 (6%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
AA G + +++ LL+ + E++ TG G +PL++AA GH+ V+ L+D
Sbjct: 1162 AASGGYVNIIKILLNAGA--EINSRTGSKLGI-SPLMLAAMNGHVPAVKLLLDM------ 1212
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
G ++ ET L A G +VV LL R A+V +T TPL A G+
Sbjct: 1213 -GSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 130 EVVRYLVGEHQADLEV--ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
EV R L+ + AD+ T L I+ KGH + L+ +GA ++ R+ KGNT L
Sbjct: 1271 EVGRVLL-DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
+ G +++QLL+ A ++ D +TPL++A GH +V+YL++E
Sbjct: 1330 WLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 89.0 bits (219), Expect = 1e-17
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 11/200 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL++AA GH+ VVE L+D+ GG + E + P L A + G +VV
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDK-------GGDIEAQSERTKDTP-LSLACSGGRQEVVD 1139
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE-HQADLEVANRHGHTCLMISCY 159
LL RGA+ ++ TPL A G++ +++ L+ + + ++ G + LM++
Sbjct: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
Query: 160 KGHREIARYLLEQGAQVNRR-SAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMT 217
GH + LL+ G+ +N + NTAL G E++ LLL KA +E R G+T
Sbjct: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
Query: 218 PLLAASVTGHTNIVEYLIQE 237
PL+ A+ G+ + L+ +
Sbjct: 1260 PLMEAASGGYAEVGRVLLDK 1279
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 90 ASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRH 149
A + G ++ VR LL G SVN T + L AC G+ E+ + L+ H + N+
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 GHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM 209
T LM + G+ +I + LL A VN +SA GNTAL G ++I+++LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 210 E-RDGYGMTPLLAASVTGHTNIVEYLIQEQPG 240
E + G TPL+ A+ GH + L+ G
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
Score = 69.7 bits (169), Expect = 8e-12
Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 5/153 (3%)
Query: 87 LWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEV- 145
L A A GH ++V L+ R A + + TPL A GH+ VV L+ + D+E
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL-DKGGDIEAQ 1117
Query: 146 ANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGC 205
+ R T L ++C G +E+ LL +GA R+ T L A G + I+++LL
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 206 KARM-ERDG--YGMTPLLAASVTGHTNIVEYLI 235
A + R G G++PL+ A++ GH V+ L+
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Score = 66.6 bits (161), Expect = 7e-11
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 17/146 (11%)
Query: 43 TPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSL 102
T L IAA GH E L+ R H D +G PLW AS GH DVV+ L
Sbjct: 1294 TALTIAADKGHYKFCELLIHR---------GAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 103 LRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE---HQADLEVANRHGHTC----LM 155
++ GA V+ TPL +A GH++VV+YLV E +D+E R+ T L+
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIE-CMRYIATITDKELL 1403
Query: 156 ISCYKGHREIARYLLEQGAQVNRRSA 181
C++ I + +Q A+ N+ ++
Sbjct: 1404 KKCHQCVETIVKAKDQQAAEANKNAS 1429
Score = 56.6 bits (135), Expect = 7e-08
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 3/126 (2%)
Query: 112 TTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE 171
T + T L AC GH E+V L+ A +E ++ G T L+++ GH + LL+
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIA-RDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 172 QGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTN 229
+G + +S + +T L G E++ LLL A E R+ TPL A+ G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 230 IVEYLI 235
I++ L+
Sbjct: 1170 IIKILL 1175
Score = 53.9 bits (128), Expect = 5e-07
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 5/152 (3%)
Query: 90 ASAAGHLDVVRSLLRRGASVN--RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVAN 147
+S + LD + L R + N + ++ L AC DG + VR L+ E ++ +
Sbjct: 177 SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHT 235
Query: 148 RHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN-TALHDCAESGSLEILQLLLGCK 206
G + L ++C G+ E+A+ LL A V R KG+ T L + G L+I++LLL
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 207 ARM-ERDGYGMTPLLAASVTGHTNIVEYLIQE 237
A + + G T L A G +IV+ L+ E
Sbjct: 296 ADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Score = 43.9 bits (102), Expect = 5e-04
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 3/104 (2%)
Query: 142 DLEVANRHGH-TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQ 200
D++ H T L ++C GH E+ L+ + A++ R KG T L A +G + +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 201 LLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
+LL G + + TPL A G +V+ L+ +E
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE 1149
Score = 38.9 bits (89), Expect = 0.016
Identities = 32/112 (28%), Positives = 49/112 (43%), Gaps = 14/112 (12%)
Query: 510 CTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLD 569
C E L + R K R K GFTPL +A +VG VV++LLD
Sbjct: 1063 CAGGHEELVSVLIARDAKIEHRDKKGFTPLILAA--TAGHVG-----------VVEILLD 1109
Query: 570 CGADPDSR-DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
G D +++ + +TPL +A +++ L+ GA+ + N T L
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 38.9 bits (89), Expect = 0.016
Identities = 48/221 (21%), Positives = 85/221 (38%), Gaps = 33/221 (14%)
Query: 420 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGS-LGTQIGFADLMGVLTKG-VREVER 477
+ N+ +P++ ++ + + +L A S G+++G + LM G V V+
Sbjct: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
Query: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFT 537
L + + + + A+ L C + + + R R K G T
Sbjct: 1209 LLDMGSDINAQIETNRNTALTL---------ACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
Query: 538 PLHMAVDKDTTNVGRY-------------PVGRFPSLHVV---------KVLLDCGADPD 575
PL A VGR P R +L + ++L+ GA D
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
Query: 576 SRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
R+ NTPL +A+ ++ L++AGA +DA + K T
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKIT 1360
Score = 32.7 bits (73), Expect = 1.1
Identities = 20/59 (33%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA-TNAFKKTAYEL 620
+VKVLL+ GA+ + + + +TPL AA + L++ GA ++ +N FK++A L
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Score = 32.0 bits (71), Expect = 1.9
Identities = 48/180 (26%), Positives = 72/180 (40%), Gaps = 35/180 (19%)
Query: 430 MTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL-----QLPRE 484
+T + F AE+ S +L DR A + G LM + G EV R L +
Sbjct: 1228 LTLACFQGRAEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 485 PGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK--HQTVYRLLKCAPRGKNGFTPLHMA 542
P S++ T AL I + H K ++R R K G TPL +A
Sbjct: 1287 PVPSSRDT-ALTI-------------AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 543 VDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIE 602
+N G + V V++L+ GAD D+ D TPL A + ++ L++
Sbjct: 1333 -----SNGGHFDV--------VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 107 bits (266), Expect = 5e-23
Identities = 78/236 (33%), Positives = 117/236 (49%), Gaps = 11/236 (4%)
Query: 3 LRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVD 62
L+ A+ AA G ++Q LL E++ + G T L AA G L+V E L+
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1092
Query: 63 RCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRA 122
GA+V G PPL+ A+ GH +VR LL RG VN + + TPL
Sbjct: 1093 H-GAAVSRTNR--------RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
Query: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
A +GHL V +L+ + A L ++ G + L +C KGHR + +YL+E+GA +++
Sbjct: 1144 AACEGHLSTVEFLLSKGAA-LSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
Query: 183 GNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQE 237
G T L A G E + L+ A +E D GM PL A +T++V L+++
Sbjct: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258
Score = 80.5 bits (197), Expect = 5e-15
Identities = 77/245 (31%), Positives = 114/245 (46%), Gaps = 14/245 (5%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ AA G ++L+ L R + + G+ A L+ +A GH D+++YL+
Sbjct: 962 TALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA-----LVHSALRGHGDILQYLLTCE 1016
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLL----RRGASVNRT-TRTNSTP 119
+ ++ A L AA++ GH VV+ LL VN T T T
Sbjct: 1017 WSPGPPQPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1074
Query: 120 LRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRR 179
L AA G LEV L+G H A + NR G L + +GH +I R LLE+G VN
Sbjct: 1075 LTAAAGRGKLEVCELLLG-HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
Query: 180 SAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQEQ 238
+G T L A G L ++ LL A + D G++ L A + GH +V+YL++E
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
Query: 239 PGQEQ 243
+Q
Sbjct: 1194 AAIDQ 1198
Score = 80.1 bits (196), Expect = 6e-15
Identities = 62/212 (29%), Positives = 98/212 (46%), Gaps = 15/212 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ AA GKL++ + LL + G PL AAR GH +V L++R
Sbjct: 1073 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGV-----PPLFCAARQGHWQIVRLLLER- 1126
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
G V+ + +G PL A+ GHL V LL +GA+++ + + L AC
Sbjct: 1127 ------GCDVNLSDK--QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1178
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
GH VV+YLV E A ++ +++G T L ++ + G E YL+E+GA + G
Sbjct: 1179 LKGHRAVVQYLV-EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
Query: 185 TALHDCAESGSLEILQLLLGCKARMERDGYGM 216
L + ++ LL A++ + M
Sbjct: 1238 RPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM 1269
Score = 62.8 bits (151), Expect = 1e-09
Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 47/212 (22%)
Query: 71 GGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLE 130
G +V++ E + AP L S GH +VV LL GA ++ T+ T L A GH++
Sbjct: 915 GANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 974
Query: 131 VVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL-------------------- 170
+V L+ + ++ ++ G L+ S +GH +I +YLL
Sbjct: 975 LV-CLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1033
Query: 171 ------------------------EQGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGC 205
E +VN G TAL A G LE+ +LLLG
Sbjct: 1034 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1093
Query: 206 KARMER-DGYGMTPLLAASVTGHTNIVEYLIQ 236
A + R + G+ PL A+ GH IV L++
Sbjct: 1094 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1125
Score = 36.6 bits (83), Expect = 0.077
Identities = 29/78 (37%), Positives = 39/78 (50%), Gaps = 9/78 (11%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL +AA YG + V YLV++ GA +E H D G PL A + VV
Sbjct: 1203 GRTPLDLAAFYGDAETVLYLVEK-GAVIE-----HVDHS---GMRPLDRAIGCRNTSVVV 1253
Query: 101 SLLRRGASVNRTTRTNST 118
+LLR+GA + +T
Sbjct: 1254 ALLRKGAKLGNAAWAMAT 1271
Score = 31.6 bits (70), Expect = 2.5
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLD 622
+V++LL+ G D + D TPL +AA + + L+ GA A ++ K L
Sbjct: 1119 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA---ALSSLDKEGLSALS 1175
Query: 623 EKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAF 665
L +G Y+ + A DKN G P DL AF
Sbjct: 1176 WACL-KGHRAVVQYLVEEGAAIDQTDKN-----GRTPLDLAAF 1212
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 107 bits (266), Expect = 5e-23
Identities = 78/236 (33%), Positives = 117/236 (49%), Gaps = 11/236 (4%)
Query: 3 LRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVD 62
L+ A+ AA G ++Q LL E++ + G T L AA G L+V E L+
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1100
Query: 63 RCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRA 122
GA+V G PPL+ A+ GH +VR LL RG VN + + TPL
Sbjct: 1101 H-GAAVSRTNR--------RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
Query: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
A +GHL V +L+ + A L ++ G + L +C KGHR + +YL+E+GA +++
Sbjct: 1152 AACEGHLSTVEFLLSKGAA-LSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
Query: 183 GNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQE 237
G T L A G E + L+ A +E D GM PL A +T++V L+++
Sbjct: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1266
Score = 80.5 bits (197), Expect = 5e-15
Identities = 77/245 (31%), Positives = 114/245 (46%), Gaps = 14/245 (5%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ AA G ++L+ L R + + G+ A L+ +A GH D+++YL+
Sbjct: 970 TALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA-----LVHSALRGHGDILQYLLTCE 1024
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLL----RRGASVNRT-TRTNSTP 119
+ ++ A L AA++ GH VV+ LL VN T T T
Sbjct: 1025 WSPGPPQPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1082
Query: 120 LRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRR 179
L AA G LEV L+G H A + NR G L + +GH +I R LLE+G VN
Sbjct: 1083 LTAAAGRGKLEVCELLLG-HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
Query: 180 SAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQEQ 238
+G T L A G L ++ LL A + D G++ L A + GH +V+YL++E
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
Query: 239 PGQEQ 243
+Q
Sbjct: 1202 AAIDQ 1206
Score = 80.1 bits (196), Expect = 6e-15
Identities = 62/212 (29%), Positives = 98/212 (46%), Gaps = 15/212 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ AA GKL++ + LL + G PL AAR GH +V L++R
Sbjct: 1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGV-----PPLFCAARQGHWQIVRLLLER- 1134
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
G V+ + +G PL A+ GHL V LL +GA+++ + + L AC
Sbjct: 1135 ------GCDVNLSDK--QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1186
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
GH VV+YLV E A ++ +++G T L ++ + G E YL+E+GA + G
Sbjct: 1187 LKGHRAVVQYLV-EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
Query: 185 TALHDCAESGSLEILQLLLGCKARMERDGYGM 216
L + ++ LL A++ + M
Sbjct: 1246 RPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM 1277
Score = 62.8 bits (151), Expect = 1e-09
Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 47/212 (22%)
Query: 71 GGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLE 130
G +V++ E + AP L S GH +VV LL GA ++ T+ T L A GH++
Sbjct: 923 GANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 982
Query: 131 VVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL-------------------- 170
+V L+ + ++ ++ G L+ S +GH +I +YLL
Sbjct: 983 LV-CLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1041
Query: 171 ------------------------EQGAQVNRRSAK-GNTALHDCAESGSLEILQLLLGC 205
E +VN G TAL A G LE+ +LLLG
Sbjct: 1042 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1101
Query: 206 KARMER-DGYGMTPLLAASVTGHTNIVEYLIQ 236
A + R + G+ PL A+ GH IV L++
Sbjct: 1102 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1133
Score = 36.6 bits (83), Expect = 0.077
Identities = 29/78 (37%), Positives = 39/78 (50%), Gaps = 9/78 (11%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL +AA YG + V YLV++ GA +E H D G PL A + VV
Sbjct: 1211 GRTPLDLAAFYGDAETVLYLVEK-GAVIE-----HVDHS---GMRPLDRAIGCRNTSVVV 1261
Query: 101 SLLRRGASVNRTTRTNST 118
+LLR+GA + +T
Sbjct: 1262 ALLRKGAKLGNAAWAMAT 1279
Score = 31.6 bits (70), Expect = 2.5
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 563 VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLD 622
+V++LL+ G D + D TPL +AA + + L+ GA A ++ K L
Sbjct: 1127 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA---ALSSLDKEGLSALS 1183
Query: 623 EKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAF 665
L +G Y+ + A DKN G P DL AF
Sbjct: 1184 WACL-KGHRAVVQYLVEEGAAIDQTDKN-----GRTPLDLAAF 1220
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 103 bits (257), Expect = 5e-22
Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GK+++ + LL R+ G+ G TPL +A + +LD+V+ L+ R
Sbjct: 571 TPLHVAAKYGKVRVAELLLE---RDAHPNAAGK--NGLTPLHVAVHHNNLDIVKLLLPR- 624
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GGS H G PL A+ ++V RSLL+ G S N + TPL A
Sbjct: 625 ------GGSPH--SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+ + QA+ + N+ G T L + +GH +A L++ G V+ + G
Sbjct: 677 QEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH + G++++++ LL +A + + G +PL A+ GHT+IV L++ +
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Query: 244 VAGGEAQP 251
V+ P
Sbjct: 796 VSSDGTTP 803
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D T ++ AA G ++ + LL ++ L G TPL IA + H+ V+E L
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-----TPLHIACKKNHVRVMELL 423
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
+ + GAS++A T G PL AS GHL +V++LL+RGAS N + TPL
Sbjct: 424 L-KTGASIDA--------VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A GH EV +YL+ +++A + + T L + GH + + LLE A N +
Sbjct: 475 HMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 181 AKGNTALHDCAESGSLEILQLLL---GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
G+T LH A G +E + LL +A M + G+ TPL A+ G + E L++
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLE 590
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/236 (32%), Positives = 119/236 (50%), Gaps = 16/236 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ AA+ L ++ LL + E+D++T + TPL +AA GH V + L+D+ GA
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDA--EIDDITLDHL---TPLHVAAHCGHHRVAKVLLDK-GA 395
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + G PL A H+ V+ LL+ GAS++ T + TPL A F
Sbjct: 396 KPNS--------RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GHL +V+ L+ + A V+N T L ++ GH E+A+YLL+ A+VN ++ T
Sbjct: 448 GHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
LH A G +++LLL A G TPL A+ GH V L++++ Q
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IA+R G++ +V L+DR GA +E +T + PL A+ GH+ +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDR-GAQIET--------KTKDELTPLHCAARNGHVRISE 322
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL GA + T+ +P+ A HL+ VR L+ ++ A+++ T L ++ +
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHC 381
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPL 219
GH +A+ LL++GA+ N R+ G T LH + + +++LLL A ++ G+TPL
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Query: 220 LAASVTGHTNIVEYLIQ 236
AS GH IV+ L+Q
Sbjct: 442 HVASFMGHLPIVKNLLQ 458
Score = 96.7 bits (239), Expect = 6e-20
Identities = 149/598 (24%), Positives = 241/598 (40%), Gaps = 78/598 (13%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREEL---DELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
T ++ A+R G + +++ LL ++ E DELT PL AAR GH+ + E L+
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELT--------PLHCAARNGHVRISEILL 325
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GA ++A +T G P+ A+ HLD VR LL+ A ++ T + TPL
Sbjct: 326 DH-GAPIQA--------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 376
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A GH V + L+ + A +G T L I+C K H + LL+ GA ++ +
Sbjct: 377 VAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGM-TPLLAASVTGHTNIVEYLIQEQPG 240
G T LH + G L I++ LL A + TPL A+ GHT + +YL+Q
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ---- 491
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPT-------- 292
+A+ +D T CA G ++ + L + + T
Sbjct: 492 ------NKAKVNAKAKDDQTPLHCAARIGH---TNMVKLLLENNANPNLATTAGHTPLHI 542
Query: 293 -SREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYS 351
+RE VE + L ++K+ K + H +Y K +L+L D
Sbjct: 543 AAREGHVETVLAL----LEKEASQACMTK---KGFTPLHVAAKY-GKVRVAELLLERDAH 594
Query: 352 REVNTTEELEALITDPDEMRMQAL-LIRERILGPSHPDTSYYIRYRGAVYADSGNFERCI 410
L L + + L+ R P P + Y + A E
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH--IAAKQNQVEVAR 652
Query: 411 RLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTK 470
L +Y +++ ++P+ ++ AE+ + +L + A G+LG + G L V +
Sbjct: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-SKQANGNLGNKSGLTPLHLVAQE 711
Query: 471 GVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAP 530
G V L D+ T+ LH+ ++ + L+HQ
Sbjct: 712 GHVPVADVLIKHGVMVDAT--TRMGYTPLHVASHYGNIKLV--KFLLQHQA-----DVNA 762
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
+ K G++PLH A + T+ +V +LL GA P+ D TPL IA
Sbjct: 763 KTKLGYSPLHQAAQQGHTD-------------IVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/255 (29%), Positives = 124/255 (48%), Gaps = 43/255 (16%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A+++G ++++ +LL +E + E T + G T L IAA G +VV LV+ GA+V
Sbjct: 85 ASKEGHVKMVVELLH---KEIILETTTKK--GNTALHIAALAGQDEVVRELVNY-GANVN 138
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A ++ +G PL+ A+ HL+VV+ LL GA+ N T TPL A GH
Sbjct: 139 A--------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 190
Query: 130 EVVRYLVG----------------------------EHQADLEVANRHGHTCLMISCYKG 161
VV +L+ ++ + +V ++ G T L I+ +
Sbjct: 191 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 250
Query: 162 HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLL 220
+ +A+ LL +GA VN G T LH + G++ +++LLL A++E + +TPL
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 310
Query: 221 AASVTGHTNIVEYLI 235
A+ GH I E L+
Sbjct: 311 CAARNGHVRISEILL 325
Score = 65.5 bits (158), Expect = 2e-10
Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 19/226 (8%)
Query: 20 QKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLD-VVEYLVDRCGASVEAGGSVHFDG 78
+K S R R + A T L AAR G+LD +++L R G + +G
Sbjct: 24 EKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNG 81
Query: 79 ETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE 138
L AS GH+ +V LL + + TT+ +T L A G EVVR LV
Sbjct: 82 --------LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 132
Query: 139 HQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEI 198
+ A++ ++ G T L ++ + H E+ ++LLE GA N + G T L + G +
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 199 LQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
+ L+ G K ++ + L A+ T L+Q P +
Sbjct: 193 VAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPD 233
Score = 53.1 bits (126), Expect = 8e-07
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 20/97 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRY-----------PVGRFPSLHVV---------KVLLDCGA 572
KNG +P+HMA D + R + LHV KVLLD GA
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
P+SR + TPLHIA + N +M L++ GA +DA
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 23/182 (12%)
Query: 428 SPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGD 487
+P+ ++ + + +L++ A +L T G L +G VE L L +
Sbjct: 505 TPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREG--HVETVLALLEKEAS 561
Query: 488 SAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDT 547
A TK LH+ KV E L + + GKNG TPLH+AV +
Sbjct: 562 QACMTKKGFTPLHVAAKYGKVRVA---ELLLERDAHP----NAAGKNGLTPLHVAVHHN- 613
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+L +VK+LL G P S ++ TPLHIAA+ N + +L++ G
Sbjct: 614 ------------NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
Query: 608 DA 609
+A
Sbjct: 662 NA 663
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 42/235 (17%)
Query: 399 VYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQ 458
+ A +G E L Y ++ + + +P+ ++ + E+ ++L++ A ++ T+
Sbjct: 117 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATE 175
Query: 459 IGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK 518
GF L L +G V L + + L L++ + + T
Sbjct: 176 DGFTPLAVALQQGHENVVAHL---------INYGTKGKVRLPALHIAARNDDT------- 219
Query: 519 HQTVYRLLKCAPR----GKNGFTPLHMAVDKDTTNVGRYPVGRFPS-----------LHV 563
+T LL+ P K GFTPLH+A + NV + + R S LH+
Sbjct: 220 -RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Query: 564 ---------VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
V++LLD GA +++ D TPLH AA+N I L++ GA + A
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 18/106 (16%)
Query: 516 HLKHQTVYRLL-----KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V ++L K R NGFTPLH+A K+ + V+++LL
Sbjct: 380 HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-------------HVRVMELLLKT 426
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
GA D+ TPLH+A+ I+ L++ GA + +N +T
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472
Score = 38.5 bits (88), Expect = 0.020
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 33/149 (22%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ + GFTPL+MA ++ L VVK LL+ GA+ + D TPL +A Q
Sbjct: 140 QSQKGFTPLYMAAQEN-------------HLEVVKFLLENGANQNVATEDGFTPLAVALQ 186
Query: 591 NNCPAIMNALIEAGA---------HMDATNAFKKTAYELL----DEKLLARGTMQPF--- 634
++ LI G H+ A N +TA LL + +L++ P
Sbjct: 187 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246
Query: 635 ----NYVTLQCLAARALDKNKIPYKGFIP 659
N Q L R N P G P
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITP 275
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 401 ADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQI 459
A G+ C+RL +Y ++ L+ L+P+ ++ + + VL D+ AK +
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALN 403
Query: 460 GFADL-----------MGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV 508
GF L M +L K ++ + P A F L I+ +LL +
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QR 459
Query: 509 ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLL 568
+P+ ++K +T PLHMA T V +Y LL
Sbjct: 460 GASPNVSNVKVET----------------PLHMAARAGHTEVAKY-------------LL 490
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAH 606
A +++ D+ TPLH AA+ ++ L+E A+
Sbjct: 491 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
Score = 34.3 bits (77), Expect = 0.38
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 20/93 (21%)
Query: 533 KNGFTPLHMAVDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGA 572
K+G TPLH+ + TT +G P+ + ++ +VK LL A
Sbjct: 699 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
D +++ +PLH AAQ I+ L++ GA
Sbjct: 759 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 791
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 103 bits (257), Expect = 5e-22
Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GK+++ + LL R+ G+ G TPL +A + +LD+V+ L+ R
Sbjct: 538 TPLHVAAKYGKVRVAELLLE---RDAHPNAAGK--NGLTPLHVAVHHNNLDIVKLLLPR- 591
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GGS H G PL A+ ++V RSLL+ G S N + TPL A
Sbjct: 592 ------GGSPH--SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+ + QA+ + N+ G T L + +GH +A L++ G V+ + G
Sbjct: 644 QEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH + G++++++ LL +A + + G +PL A+ GHT+IV L++ +
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 244 VAGGEAQP 251
V+ P
Sbjct: 763 VSSDGTTP 770
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D T ++ AA G ++ + LL ++ L G TPL IA + H+ V+E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-----TPLHIACKKNHVRVMELL 390
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
+ + GAS++A T G PL AS GHL +V++LL+RGAS N + TPL
Sbjct: 391 L-KTGASIDA--------VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A GH EV +YL+ +++A + + T L + GH + + LLE A N +
Sbjct: 442 HMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 181 AKGNTALHDCAESGSLEILQLLL---GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
G+T LH A G +E + LL +A M + G+ TPL A+ G + E L++
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLE 557
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/236 (32%), Positives = 119/236 (50%), Gaps = 16/236 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ AA+ L ++ LL + E+D++T + TPL +AA GH V + L+D+ GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDA--EIDDITLDHL---TPLHVAAHCGHHRVAKVLLDK-GA 362
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + G PL A H+ V+ LL+ GAS++ T + TPL A F
Sbjct: 363 KPNS--------RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GHL +V+ L+ + A V+N T L ++ GH E+A+YLL+ A+VN ++ T
Sbjct: 415 GHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
LH A G +++LLL A G TPL A+ GH V L++++ Q
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IA+R G++ +V L+DR GA +E +T + PL A+ GH+ +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDR-GAQIET--------KTKDELTPLHCAARNGHVRISE 289
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL GA + T+ +P+ A HL+ VR L+ ++ A+++ T L ++ +
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHC 348
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPL 219
GH +A+ LL++GA+ N R+ G T LH + + +++LLL A ++ G+TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 220 LAASVTGHTNIVEYLIQ 236
AS GH IV+ L+Q
Sbjct: 409 HVASFMGHLPIVKNLLQ 425
Score = 96.7 bits (239), Expect = 6e-20
Identities = 149/598 (24%), Positives = 241/598 (40%), Gaps = 78/598 (13%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREEL---DELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
T ++ A+R G + +++ LL ++ E DELT PL AAR GH+ + E L+
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELT--------PLHCAARNGHVRISEILL 292
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GA ++A +T G P+ A+ HLD VR LL+ A ++ T + TPL
Sbjct: 293 DH-GAPIQA--------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A GH V + L+ + A +G T L I+C K H + LL+ GA ++ +
Sbjct: 344 VAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGM-TPLLAASVTGHTNIVEYLIQEQPG 240
G T LH + G L I++ LL A + TPL A+ GHT + +YL+Q
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ---- 458
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPT-------- 292
+A+ +D T CA G ++ + L + + T
Sbjct: 459 ------NKAKVNAKAKDDQTPLHCAARIGH---TNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 293 -SREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYS 351
+RE VE + L ++K+ K + H +Y K +L+L D
Sbjct: 510 AAREGHVETVLAL----LEKEASQACMTK---KGFTPLHVAAKY-GKVRVAELLLERDAH 561
Query: 352 REVNTTEELEALITDPDEMRMQAL-LIRERILGPSHPDTSYYIRYRGAVYADSGNFERCI 410
L L + + L+ R P P + Y + A E
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH--IAAKQNQVEVAR 619
Query: 411 RLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTK 470
L +Y +++ ++P+ ++ AE+ + +L + A G+LG + G L V +
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-SKQANGNLGNKSGLTPLHLVAQE 678
Query: 471 GVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAP 530
G V L D+ T+ LH+ ++ + L+HQ
Sbjct: 679 GHVPVADVLIKHGVMVDAT--TRMGYTPLHVASHYGNIKLV--KFLLQHQA-----DVNA 729
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
+ K G++PLH A + T+ +V +LL GA P+ D TPL IA
Sbjct: 730 KTKLGYSPLHQAAQQGHTD-------------IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/255 (29%), Positives = 124/255 (48%), Gaps = 43/255 (16%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A+++G ++++ +LL +E + E T + G T L IAA G +VV LV+ GA+V
Sbjct: 52 ASKEGHVKMVVELLH---KEIILETTTKK--GNTALHIAALAGQDEVVRELVNY-GANVN 105
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A ++ +G PL+ A+ HL+VV+ LL GA+ N T TPL A GH
Sbjct: 106 A--------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 130 EVVRYLVG----------------------------EHQADLEVANRHGHTCLMISCYKG 161
VV +L+ ++ + +V ++ G T L I+ +
Sbjct: 158 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 162 HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLL 220
+ +A+ LL +GA VN G T LH + G++ +++LLL A++E + +TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277
Query: 221 AASVTGHTNIVEYLI 235
A+ GH I E L+
Sbjct: 278 CAARNGHVRISEILL 292
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 19/207 (9%)
Query: 39 AGGGTPLLIAARYGHLD-VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLD 97
A T L AAR G+LD +++L R G + +G L AS GH+
Sbjct: 10 ADAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNG--------LHLASKEGHVK 59
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
+V LL + + TT+ +T L A G EVVR LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMA 118
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLL--GCKARMERDGYG 215
+ H E+ ++LLE GA N + G T L + G ++ L+ G K ++
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----- 173
Query: 216 MTPLLAASVTGHTNIVEYLIQEQPGQE 242
+ L A+ T L+Q P +
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 53.1 bits (126), Expect = 8e-07
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 20/97 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRY-----------PVGRFPSLHVV---------KVLLDCGA 572
KNG +P+HMA D + R + LHV KVLLD GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
P+SR + TPLHIA + N +M L++ GA +DA
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 23/182 (12%)
Query: 428 SPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGD 487
+P+ ++ + + +L++ A +L T G L +G VE L L +
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREG--HVETVLALLEKEAS 528
Query: 488 SAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDT 547
A TK LH+ KV E L + + GKNG TPLH+AV +
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVA---ELLLERDAHP----NAAGKNGLTPLHVAVHHN- 580
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+L +VK+LL G P S ++ TPLHIAA+ N + +L++ G
Sbjct: 581 ------------NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 608 DA 609
+A
Sbjct: 629 NA 630
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 42/235 (17%)
Query: 399 VYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQ 458
+ A +G E L Y ++ + + +P+ ++ + E+ ++L++ A ++ T+
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATE 142
Query: 459 IGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK 518
GF L L +G V L + + L L++ + + T
Sbjct: 143 DGFTPLAVALQQGHENVVAHL---------INYGTKGKVRLPALHIAARNDDT------- 186
Query: 519 HQTVYRLLKCAPR----GKNGFTPLHMAVDKDTTNVGRYPVGRFPS-----------LHV 563
+T LL+ P K GFTPLH+A + NV + + R S LH+
Sbjct: 187 -RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 564 ---------VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
V++LLD GA +++ D TPLH AA+N I L++ GA + A
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 18/106 (16%)
Query: 516 HLKHQTVYRLL-----KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V ++L K R NGFTPLH+A K+ + V+++LL
Sbjct: 347 HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-------------HVRVMELLLKT 393
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
GA D+ TPLH+A+ I+ L++ GA + +N +T
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Score = 38.5 bits (88), Expect = 0.020
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 33/149 (22%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ + GFTPL+MA ++ L VVK LL+ GA+ + D TPL +A Q
Sbjct: 107 QSQKGFTPLYMAAQEN-------------HLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 591 NNCPAIMNALIEAGA---------HMDATNAFKKTAYELL----DEKLLARGTMQPF--- 634
++ LI G H+ A N +TA LL + +L++ P
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 635 ----NYVTLQCLAARALDKNKIPYKGFIP 659
N Q L R N P G P
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITP 242
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 401 ADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQI 459
A G+ C+RL +Y ++ L+ L+P+ ++ + + VL D+ AK +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALN 370
Query: 460 GFADL-----------MGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV 508
GF L M +L K ++ + P A F L I+ +LL +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QR 426
Query: 509 ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLL 568
+P+ ++K +T PLHMA T V +Y LL
Sbjct: 427 GASPNVSNVKVET----------------PLHMAARAGHTEVAKY-------------LL 457
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAH 606
A +++ D+ TPLH AA+ ++ L+E A+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Score = 34.3 bits (77), Expect = 0.38
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 20/93 (21%)
Query: 533 KNGFTPLHMAVDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGA 572
K+G TPLH+ + TT +G P+ + ++ +VK LL A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
D +++ +PLH AAQ I+ L++ GA
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 103 bits (257), Expect = 5e-22
Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GK+++ + LL R+ G+ G TPL +A + +LD+V+ L+ R
Sbjct: 538 TPLHVAAKYGKVRVAELLLE---RDAHPNAAGK--NGLTPLHVAVHHNNLDIVKLLLPR- 591
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GGS H G PL A+ ++V RSLL+ G S N + TPL A
Sbjct: 592 ------GGSPH--SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+ + QA+ + N+ G T L + +GH +A L++ G V+ + G
Sbjct: 644 QEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH + G++++++ LL +A + + G +PL A+ GHT+IV L++ +
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 244 VAGGEAQP 251
V+ P
Sbjct: 763 VSSDGTTP 770
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D T ++ AA G ++ + LL ++ L G TPL IA + H+ V+E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-----TPLHIACKKNHVRVMELL 390
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
+ + GAS++A T G PL AS GHL +V++LL+RGAS N + TPL
Sbjct: 391 L-KTGASIDA--------VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A GH EV +YL+ +++A + + T L + GH + + LLE A N +
Sbjct: 442 HMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 181 AKGNTALHDCAESGSLEILQLLL---GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
G+T LH A G +E + LL +A M + G+ TPL A+ G + E L++
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLE 557
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/236 (32%), Positives = 119/236 (50%), Gaps = 16/236 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ AA+ L ++ LL + E+D++T + TPL +AA GH V + L+D+ GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDA--EIDDITLDHL---TPLHVAAHCGHHRVAKVLLDK-GA 362
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + G PL A H+ V+ LL+ GAS++ T + TPL A F
Sbjct: 363 KPNS--------RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GHL +V+ L+ + A V+N T L ++ GH E+A+YLL+ A+VN ++ T
Sbjct: 415 GHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
LH A G +++LLL A G TPL A+ GH V L++++ Q
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IA+R G++ +V L+DR GA +E +T + PL A+ GH+ +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDR-GAQIET--------KTKDELTPLHCAARNGHVRISE 289
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL GA + T+ +P+ A HL+ VR L+ ++ A+++ T L ++ +
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHC 348
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPL 219
GH +A+ LL++GA+ N R+ G T LH + + +++LLL A ++ G+TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 220 LAASVTGHTNIVEYLIQ 236
AS GH IV+ L+Q
Sbjct: 409 HVASFMGHLPIVKNLLQ 425
Score = 96.7 bits (239), Expect = 6e-20
Identities = 149/598 (24%), Positives = 241/598 (40%), Gaps = 78/598 (13%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREEL---DELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
T ++ A+R G + +++ LL ++ E DELT PL AAR GH+ + E L+
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELT--------PLHCAARNGHVRISEILL 292
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GA ++A +T G P+ A+ HLD VR LL+ A ++ T + TPL
Sbjct: 293 DH-GAPIQA--------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A GH V + L+ + A +G T L I+C K H + LL+ GA ++ +
Sbjct: 344 VAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGM-TPLLAASVTGHTNIVEYLIQEQPG 240
G T LH + G L I++ LL A + TPL A+ GHT + +YL+Q
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ---- 458
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPT-------- 292
+A+ +D T CA G ++ + L + + T
Sbjct: 459 ------NKAKVNAKAKDDQTPLHCAARIGH---TNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 293 -SREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYS 351
+RE VE + L ++K+ K + H +Y K +L+L D
Sbjct: 510 AAREGHVETVLAL----LEKEASQACMTK---KGFTPLHVAAKY-GKVRVAELLLERDAH 561
Query: 352 REVNTTEELEALITDPDEMRMQAL-LIRERILGPSHPDTSYYIRYRGAVYADSGNFERCI 410
L L + + L+ R P P + Y + A E
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH--IAAKQNQVEVAR 619
Query: 411 RLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTK 470
L +Y +++ ++P+ ++ AE+ + +L + A G+LG + G L V +
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-SKQANGNLGNKSGLTPLHLVAQE 678
Query: 471 GVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAP 530
G V L D+ T+ LH+ ++ + L+HQ
Sbjct: 679 GHVPVADVLIKHGVMVDAT--TRMGYTPLHVASHYGNIKLV--KFLLQHQA-----DVNA 729
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
+ K G++PLH A + T+ +V +LL GA P+ D TPL IA
Sbjct: 730 KTKLGYSPLHQAAQQGHTD-------------IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/255 (29%), Positives = 124/255 (48%), Gaps = 43/255 (16%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A+++G ++++ +LL +E + E T + G T L IAA G +VV LV+ GA+V
Sbjct: 52 ASKEGHVKMVVELLH---KEIILETTTKK--GNTALHIAALAGQDEVVRELVNY-GANVN 105
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A ++ +G PL+ A+ HL+VV+ LL GA+ N T TPL A GH
Sbjct: 106 A--------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 130 EVVRYLVG----------------------------EHQADLEVANRHGHTCLMISCYKG 161
VV +L+ ++ + +V ++ G T L I+ +
Sbjct: 158 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 162 HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLL 220
+ +A+ LL +GA VN G T LH + G++ +++LLL A++E + +TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277
Query: 221 AASVTGHTNIVEYLI 235
A+ GH I E L+
Sbjct: 278 CAARNGHVRISEILL 292
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 19/207 (9%)
Query: 39 AGGGTPLLIAARYGHLD-VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLD 97
A T L AAR G+LD +++L R G + +G L AS GH+
Sbjct: 10 ADAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNG--------LHLASKEGHVK 59
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
+V LL + + TT+ +T L A G EVVR LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMA 118
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLL--GCKARMERDGYG 215
+ H E+ ++LLE GA N + G T L + G ++ L+ G K ++
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----- 173
Query: 216 MTPLLAASVTGHTNIVEYLIQEQPGQE 242
+ L A+ T L+Q P +
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 53.1 bits (126), Expect = 8e-07
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 20/97 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRY-----------PVGRFPSLHVV---------KVLLDCGA 572
KNG +P+HMA D + R + LHV KVLLD GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
P+SR + TPLHIA + N +M L++ GA +DA
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 23/182 (12%)
Query: 428 SPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGD 487
+P+ ++ + + +L++ A +L T G L +G VE L L +
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREG--HVETVLALLEKEAS 528
Query: 488 SAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDT 547
A TK LH+ KV E L + + GKNG TPLH+AV +
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVA---ELLLERDAHP----NAAGKNGLTPLHVAVHHN- 580
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+L +VK+LL G P S ++ TPLHIAA+ N + +L++ G
Sbjct: 581 ------------NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 608 DA 609
+A
Sbjct: 629 NA 630
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 42/235 (17%)
Query: 399 VYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQ 458
+ A +G E L Y ++ + + +P+ ++ + E+ ++L++ A ++ T+
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATE 142
Query: 459 IGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK 518
GF L L +G V L + + L L++ + + T
Sbjct: 143 DGFTPLAVALQQGHENVVAHL---------INYGTKGKVRLPALHIAARNDDT------- 186
Query: 519 HQTVYRLLKCAPR----GKNGFTPLHMAVDKDTTNVGRYPVGRFPS-----------LHV 563
+T LL+ P K GFTPLH+A + NV + + R S LH+
Sbjct: 187 -RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 564 ---------VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
V++LLD GA +++ D TPLH AA+N I L++ GA + A
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 18/106 (16%)
Query: 516 HLKHQTVYRLL-----KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V ++L K R NGFTPLH+A K+ + V+++LL
Sbjct: 347 HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-------------HVRVMELLLKT 393
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
GA D+ TPLH+A+ I+ L++ GA + +N +T
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Score = 38.5 bits (88), Expect = 0.020
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 33/149 (22%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ + GFTPL+MA ++ L VVK LL+ GA+ + D TPL +A Q
Sbjct: 107 QSQKGFTPLYMAAQEN-------------HLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 591 NNCPAIMNALIEAGA---------HMDATNAFKKTAYELL----DEKLLARGTMQPF--- 634
++ LI G H+ A N +TA LL + +L++ P
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 635 ----NYVTLQCLAARALDKNKIPYKGFIP 659
N Q L R N P G P
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITP 242
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 401 ADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQI 459
A G+ C+RL +Y ++ L+ L+P+ ++ + + VL D+ AK +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALN 370
Query: 460 GFADL-----------MGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV 508
GF L M +L K ++ + P A F L I+ +LL +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QR 426
Query: 509 ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLL 568
+P+ ++K +T PLHMA T V +Y LL
Sbjct: 427 GASPNVSNVKVET----------------PLHMAARAGHTEVAKY-------------LL 457
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAH 606
A +++ D+ TPLH AA+ ++ L+E A+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Score = 34.3 bits (77), Expect = 0.38
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 20/93 (21%)
Query: 533 KNGFTPLHMAVDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGA 572
K+G TPLH+ + TT +G P+ + ++ +VK LL A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
D +++ +PLH AAQ I+ L++ GA
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 103 bits (257), Expect = 5e-22
Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GK+++ + LL R+ G+ G TPL +A + +LD+V+ L+ R
Sbjct: 538 TPLHVAAKYGKVRVAELLLE---RDAHPNAAGK--NGLTPLHVAVHHNNLDIVKLLLPR- 591
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GGS H G PL A+ ++V RSLL+ G S N + TPL A
Sbjct: 592 ------GGSPH--SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+ + QA+ + N+ G T L + +GH +A L++ G V+ + G
Sbjct: 644 QEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH + G++++++ LL +A + + G +PL A+ GHT+IV L++ +
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 244 VAGGEAQP 251
V+ P
Sbjct: 763 VSSDGTTP 770
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D T ++ AA G ++ + LL ++ L G TPL IA + H+ V+E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-----TPLHIACKKNHVRVMELL 390
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
+ + GAS++A T G PL AS GHL +V++LL+RGAS N + TPL
Sbjct: 391 L-KTGASIDA--------VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A GH EV +YL+ +++A + + T L + GH + + LLE A N +
Sbjct: 442 HMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 181 AKGNTALHDCAESGSLEILQLLL---GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
G+T LH A G +E + LL +A M + G+ TPL A+ G + E L++
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLE 557
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/236 (32%), Positives = 119/236 (50%), Gaps = 16/236 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ AA+ L ++ LL + E+D++T + TPL +AA GH V + L+D+ GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDA--EIDDITLDHL---TPLHVAAHCGHHRVAKVLLDK-GA 362
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + G PL A H+ V+ LL+ GAS++ T + TPL A F
Sbjct: 363 KPNS--------RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GHL +V+ L+ + A V+N T L ++ GH E+A+YLL+ A+VN ++ T
Sbjct: 415 GHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
LH A G +++LLL A G TPL A+ GH V L++++ Q
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IA+R G++ +V L+DR GA +E +T + PL A+ GH+ +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDR-GAQIET--------KTKDELTPLHCAARNGHVRISE 289
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL GA + T+ +P+ A HL+ VR L+ ++ A+++ T L ++ +
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHC 348
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPL 219
GH +A+ LL++GA+ N R+ G T LH + + +++LLL A ++ G+TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 220 LAASVTGHTNIVEYLIQ 236
AS GH IV+ L+Q
Sbjct: 409 HVASFMGHLPIVKNLLQ 425
Score = 96.7 bits (239), Expect = 6e-20
Identities = 149/598 (24%), Positives = 241/598 (40%), Gaps = 78/598 (13%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREEL---DELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
T ++ A+R G + +++ LL ++ E DELT PL AAR GH+ + E L+
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELT--------PLHCAARNGHVRISEILL 292
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GA ++A +T G P+ A+ HLD VR LL+ A ++ T + TPL
Sbjct: 293 DH-GAPIQA--------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A GH V + L+ + A +G T L I+C K H + LL+ GA ++ +
Sbjct: 344 VAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGM-TPLLAASVTGHTNIVEYLIQEQPG 240
G T LH + G L I++ LL A + TPL A+ GHT + +YL+Q
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ---- 458
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPT-------- 292
+A+ +D T CA G ++ + L + + T
Sbjct: 459 ------NKAKVNAKAKDDQTPLHCAARIGH---TNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 293 -SREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYS 351
+RE VE + L ++K+ K + H +Y K +L+L D
Sbjct: 510 AAREGHVETVLAL----LEKEASQACMTK---KGFTPLHVAAKY-GKVRVAELLLERDAH 561
Query: 352 REVNTTEELEALITDPDEMRMQAL-LIRERILGPSHPDTSYYIRYRGAVYADSGNFERCI 410
L L + + L+ R P P + Y + A E
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH--IAAKQNQVEVAR 619
Query: 411 RLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTK 470
L +Y +++ ++P+ ++ AE+ + +L + A G+LG + G L V +
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-SKQANGNLGNKSGLTPLHLVAQE 678
Query: 471 GVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAP 530
G V L D+ T+ LH+ ++ + L+HQ
Sbjct: 679 GHVPVADVLIKHGVMVDAT--TRMGYTPLHVASHYGNIKLV--KFLLQHQA-----DVNA 729
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
+ K G++PLH A + T+ +V +LL GA P+ D TPL IA
Sbjct: 730 KTKLGYSPLHQAAQQGHTD-------------IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/255 (29%), Positives = 124/255 (48%), Gaps = 43/255 (16%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A+++G ++++ +LL +E + E T + G T L IAA G +VV LV+ GA+V
Sbjct: 52 ASKEGHVKMVVELLH---KEIILETTTKK--GNTALHIAALAGQDEVVRELVNY-GANVN 105
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A ++ +G PL+ A+ HL+VV+ LL GA+ N T TPL A GH
Sbjct: 106 A--------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 130 EVVRYLVG----------------------------EHQADLEVANRHGHTCLMISCYKG 161
VV +L+ ++ + +V ++ G T L I+ +
Sbjct: 158 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 162 HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLL 220
+ +A+ LL +GA VN G T LH + G++ +++LLL A++E + +TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277
Query: 221 AASVTGHTNIVEYLI 235
A+ GH I E L+
Sbjct: 278 CAARNGHVRISEILL 292
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 19/207 (9%)
Query: 39 AGGGTPLLIAARYGHLD-VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLD 97
A T L AAR G+LD +++L R G + +G L AS GH+
Sbjct: 10 ADAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNG--------LHLASKEGHVK 59
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
+V LL + + TT+ +T L A G EVVR LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMA 118
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLL--GCKARMERDGYG 215
+ H E+ ++LLE GA N + G T L + G ++ L+ G K ++
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----- 173
Query: 216 MTPLLAASVTGHTNIVEYLIQEQPGQE 242
+ L A+ T L+Q P +
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 53.1 bits (126), Expect = 8e-07
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 20/97 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRY-----------PVGRFPSLHVV---------KVLLDCGA 572
KNG +P+HMA D + R + LHV KVLLD GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
P+SR + TPLHIA + N +M L++ GA +DA
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 23/182 (12%)
Query: 428 SPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGD 487
+P+ ++ + + +L++ A +L T G L +G VE L L +
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREG--HVETVLALLEKEAS 528
Query: 488 SAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDT 547
A TK LH+ KV E L + + GKNG TPLH+AV +
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVA---ELLLERDAHP----NAAGKNGLTPLHVAVHHN- 580
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+L +VK+LL G P S ++ TPLHIAA+ N + +L++ G
Sbjct: 581 ------------NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 608 DA 609
+A
Sbjct: 629 NA 630
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 42/235 (17%)
Query: 399 VYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQ 458
+ A +G E L Y ++ + + +P+ ++ + E+ ++L++ A ++ T+
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATE 142
Query: 459 IGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK 518
GF L L +G V L + + L L++ + + T
Sbjct: 143 DGFTPLAVALQQGHENVVAHL---------INYGTKGKVRLPALHIAARNDDT------- 186
Query: 519 HQTVYRLLKCAPR----GKNGFTPLHMAVDKDTTNVGRYPVGRFPS-----------LHV 563
+T LL+ P K GFTPLH+A + NV + + R S LH+
Sbjct: 187 -RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 564 ---------VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
V++LLD GA +++ D TPLH AA+N I L++ GA + A
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 18/106 (16%)
Query: 516 HLKHQTVYRLL-----KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V ++L K R NGFTPLH+A K+ + V+++LL
Sbjct: 347 HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-------------HVRVMELLLKT 393
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
GA D+ TPLH+A+ I+ L++ GA + +N +T
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Score = 38.5 bits (88), Expect = 0.020
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 33/149 (22%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ + GFTPL+MA ++ L VVK LL+ GA+ + D TPL +A Q
Sbjct: 107 QSQKGFTPLYMAAQEN-------------HLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 591 NNCPAIMNALIEAGA---------HMDATNAFKKTAYELL----DEKLLARGTMQPF--- 634
++ LI G H+ A N +TA LL + +L++ P
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 635 ----NYVTLQCLAARALDKNKIPYKGFIP 659
N Q L R N P G P
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITP 242
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 401 ADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQI 459
A G+ C+RL +Y ++ L+ L+P+ ++ + + VL D+ AK +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALN 370
Query: 460 GFADL-----------MGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV 508
GF L M +L K ++ + P A F L I+ +LL +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QR 426
Query: 509 ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLL 568
+P+ ++K +T PLHMA T V +Y LL
Sbjct: 427 GASPNVSNVKVET----------------PLHMAARAGHTEVAKY-------------LL 457
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAH 606
A +++ D+ TPLH AA+ ++ L+E A+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Score = 34.3 bits (77), Expect = 0.38
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 20/93 (21%)
Query: 533 KNGFTPLHMAVDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGA 572
K+G TPLH+ + TT +G P+ + ++ +VK LL A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
D +++ +PLH AAQ I+ L++ GA
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 103 bits (257), Expect = 5e-22
Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GK+++ + LL R+ G+ G TPL +A + +LD+V+ L+ R
Sbjct: 538 TPLHVAAKYGKVRVAELLLE---RDAHPNAAGK--NGLTPLHVAVHHNNLDIVKLLLPR- 591
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GGS H G PL A+ ++V RSLL+ G S N + TPL A
Sbjct: 592 ------GGSPH--SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH E+V L+ + QA+ + N+ G T L + +GH +A L++ G V+ + G
Sbjct: 644 QEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH + G++++++ LL +A + + G +PL A+ GHT+IV L++ +
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 244 VAGGEAQP 251
V+ P
Sbjct: 763 VSSDGTTP 770
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D T ++ AA G ++ + LL ++ L G TPL IA + H+ V+E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-----TPLHIACKKNHVRVMELL 390
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
+ + GAS++A T G PL AS GHL +V++LL+RGAS N + TPL
Sbjct: 391 L-KTGASIDA--------VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A GH EV +YL+ +++A + + T L + GH + + LLE A N +
Sbjct: 442 HMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 181 AKGNTALHDCAESGSLEILQLLL---GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
G+T LH A G +E + LL +A M + G+ TPL A+ G + E L++
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLE 557
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/236 (32%), Positives = 119/236 (50%), Gaps = 16/236 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ AA+ L ++ LL + E+D++T + TPL +AA GH V + L+D+ GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDA--EIDDITLDHL---TPLHVAAHCGHHRVAKVLLDK-GA 362
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + G PL A H+ V+ LL+ GAS++ T + TPL A F
Sbjct: 363 KPNS--------RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GHL +V+ L+ + A V+N T L ++ GH E+A+YLL+ A+VN ++ T
Sbjct: 415 GHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
LH A G +++LLL A G TPL A+ GH V L++++ Q
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 97.8 bits (242), Expect = 3e-20
Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IA+R G++ +V L+DR GA +E +T + PL A+ GH+ +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDR-GAQIET--------KTKDELTPLHCAARNGHVRISE 289
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL GA + T+ +P+ A HL+ VR L+ ++ A+++ T L ++ +
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHC 348
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-DGYGMTPL 219
GH +A+ LL++GA+ N R+ G T LH + + +++LLL A ++ G+TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 220 LAASVTGHTNIVEYLIQ 236
AS GH IV+ L+Q
Sbjct: 409 HVASFMGHLPIVKNLLQ 425
Score = 96.7 bits (239), Expect = 6e-20
Identities = 149/598 (24%), Positives = 241/598 (40%), Gaps = 78/598 (13%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREEL---DELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
T ++ A+R G + +++ LL ++ E DELT PL AAR GH+ + E L+
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELT--------PLHCAARNGHVRISEILL 292
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GA ++A +T G P+ A+ HLD VR LL+ A ++ T + TPL
Sbjct: 293 DH-GAPIQA--------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A GH V + L+ + A +G T L I+C K H + LL+ GA ++ +
Sbjct: 344 VAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARMERDGYGM-TPLLAASVTGHTNIVEYLIQEQPG 240
G T LH + G L I++ LL A + TPL A+ GHT + +YL+Q
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ---- 458
Query: 241 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPT-------- 292
+A+ +D T CA G ++ + L + + T
Sbjct: 459 ------NKAKVNAKAKDDQTPLHCAARIGH---TNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 293 -SREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYS 351
+RE VE + L ++K+ K + H +Y K +L+L D
Sbjct: 510 AAREGHVETVLAL----LEKEASQACMTK---KGFTPLHVAAKY-GKVRVAELLLERDAH 561
Query: 352 REVNTTEELEALITDPDEMRMQAL-LIRERILGPSHPDTSYYIRYRGAVYADSGNFERCI 410
L L + + L+ R P P + Y + A E
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH--IAAKQNQVEVAR 619
Query: 411 RLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTK 470
L +Y +++ ++P+ ++ AE+ + +L + A G+LG + G L V +
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-SKQANGNLGNKSGLTPLHLVAQE 678
Query: 471 GVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAP 530
G V L D+ T+ LH+ ++ + L+HQ
Sbjct: 679 GHVPVADVLIKHGVMVDAT--TRMGYTPLHVASHYGNIKLV--KFLLQHQA-----DVNA 729
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIA 588
+ K G++PLH A + T+ +V +LL GA P+ D TPL IA
Sbjct: 730 KTKLGYSPLHQAAQQGHTD-------------IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 85.1 bits (209), Expect = 2e-16
Identities = 76/255 (29%), Positives = 124/255 (48%), Gaps = 43/255 (16%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
A+++G ++++ +LL +E + E T + G T L IAA G +VV LV+ GA+V
Sbjct: 52 ASKEGHVKMVVELLH---KEIILETTTKK--GNTALHIAALAGQDEVVRELVNY-GANVN 105
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A ++ +G PL+ A+ HL+VV+ LL GA+ N T TPL A GH
Sbjct: 106 A--------QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 130 EVVRYLVG----------------------------EHQADLEVANRHGHTCLMISCYKG 161
VV +L+ ++ + +V ++ G T L I+ +
Sbjct: 158 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Query: 162 HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLL 220
+ +A+ LL +GA VN G T LH + G++ +++LLL A++E + +TPL
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277
Query: 221 AASVTGHTNIVEYLI 235
A+ GH I E L+
Sbjct: 278 CAARNGHVRISEILL 292
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 19/207 (9%)
Query: 39 AGGGTPLLIAARYGHLD-VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLD 97
A T L AAR G+LD +++L R G + +G L AS GH+
Sbjct: 10 ADAATSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNG--------LHLASKEGHVK 59
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
+V LL + + TT+ +T L A G EVVR LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMA 118
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLL--GCKARMERDGYG 215
+ H E+ ++LLE GA N + G T L + G ++ L+ G K ++
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----- 173
Query: 216 MTPLLAASVTGHTNIVEYLIQEQPGQE 242
+ L A+ T L+Q P +
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 53.1 bits (126), Expect = 8e-07
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 20/97 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRY-----------PVGRFPSLHVV---------KVLLDCGA 572
KNG +P+HMA D + R + LHV KVLLD GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
P+SR + TPLHIA + N +M L++ GA +DA
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 23/182 (12%)
Query: 428 SPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGD 487
+P+ ++ + + +L++ A +L T G L +G VE L L +
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREG--HVETVLALLEKEAS 528
Query: 488 SAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDT 547
A TK LH+ KV E L + + GKNG TPLH+AV +
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVA---ELLLERDAHP----NAAGKNGLTPLHVAVHHN- 580
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+L +VK+LL G P S ++ TPLHIAA+ N + +L++ G
Sbjct: 581 ------------NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 608 DA 609
+A
Sbjct: 629 NA 630
Score = 49.7 bits (117), Expect = 9e-06
Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 42/235 (17%)
Query: 399 VYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQ 458
+ A +G E L Y ++ + + +P+ ++ + E+ ++L++ A ++ T+
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATE 142
Query: 459 IGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLK 518
GF L L +G V L + + L L++ + + T
Sbjct: 143 DGFTPLAVALQQGHENVVAHL---------INYGTKGKVRLPALHIAARNDDT------- 186
Query: 519 HQTVYRLLKCAPR----GKNGFTPLHMAVDKDTTNVGRYPVGRFPS-----------LHV 563
+T LL+ P K GFTPLH+A + NV + + R S LH+
Sbjct: 187 -RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 564 ---------VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
V++LLD GA +++ D TPLH AA+N I L++ GA + A
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 18/106 (16%)
Query: 516 HLKHQTVYRLL-----KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V ++L K R NGFTPLH+A K+ + V+++LL
Sbjct: 347 HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-------------HVRVMELLLKT 393
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
GA D+ TPLH+A+ I+ L++ GA + +N +T
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Score = 38.5 bits (88), Expect = 0.020
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 33/149 (22%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ + GFTPL+MA ++ L VVK LL+ GA+ + D TPL +A Q
Sbjct: 107 QSQKGFTPLYMAAQEN-------------HLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 591 NNCPAIMNALIEAGA---------HMDATNAFKKTAYELL----DEKLLARGTMQPF--- 634
++ LI G H+ A N +TA LL + +L++ P
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 635 ----NYVTLQCLAARALDKNKIPYKGFIP 659
N Q L R N P G P
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITP 242
Score = 37.4 bits (85), Expect = 0.045
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 401 ADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQI 459
A G+ C+RL +Y ++ L+ L+P+ ++ + + VL D+ AK +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALN 370
Query: 460 GFADL-----------MGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKV 508
GF L M +L K ++ + P A F L I+ +LL +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QR 426
Query: 509 ECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLL 568
+P+ ++K +T PLHMA T V +Y LL
Sbjct: 427 GASPNVSNVKVET----------------PLHMAARAGHTEVAKY-------------LL 457
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAH 606
A +++ D+ TPLH AA+ ++ L+E A+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Score = 34.3 bits (77), Expect = 0.38
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 20/93 (21%)
Query: 533 KNGFTPLHMAVDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGA 572
K+G TPLH+ + TT +G P+ + ++ +VK LL A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
D +++ +PLH AAQ I+ L++ GA
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 103 bits (256), Expect = 7e-22
Identities = 160/674 (23%), Positives = 260/674 (38%), Gaps = 143/674 (21%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D + AAR G L + + L G ++ G L +AA+ GH+ +V+ L+
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGI-----DINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
R G+SV D T +G L AS AG +VV+ L++ GA++N ++ TPL
Sbjct: 64 GR-GSSV--------DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 114
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ------ 175
A + H++VV+YL+ E+ A+ A G T L ++ +GH + LLE +
Sbjct: 115 MAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 173
Query: 176 -------------------------------VNRRSAKGNTALHDCAESGSLEILQLLLG 204
VNR + G T LH A G++ + LLL
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 205 CKARMERDG-YGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQG 263
A ++ G+TPL AS G+TN+V+ L+ GG Q D T G
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR--------GG-------QIDAKTRDG 278
Query: 264 CAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWR 323
PL+ C +R + +ELL +++ LL K+
Sbjct: 279 LT--------------PLH------C--AARSGHDQVVELL----LERGAPLLARTKNGL 312
Query: 324 RAMELRHQGG-----EYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIR 378
+ + QG ++L + + P + DY ++ R+ LL+
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC-------GHYRVTKLLLD 365
Query: 379 ERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLS 437
+R ++P+ + A N + + L KY +Q L+P+ ++F+
Sbjct: 366 KR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 421
Query: 438 FAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAI 497
+ +LQ+ A+ + G L G EV R L D+ +
Sbjct: 422 HLNIVLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDAR--AREEQT 478
Query: 498 ILHLLYLLEKVECTP-SQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGR---- 552
LH+ L K E +H+ H NG+TPLH++ + +V
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDA--------ATTNGYTPLHISAREGQVDVASVLLE 530
Query: 553 ----------------YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAI 596
+ ++ SL V K+LL A DS + TPLH+AA + +
Sbjct: 531 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590
Query: 597 MNALIEAGAHMDAT 610
L+E GA AT
Sbjct: 591 ALLLLEKGASPHAT 604
Score = 97.4 bits (241), Expect = 4e-20
Identities = 76/288 (26%), Positives = 127/288 (44%), Gaps = 64/288 (22%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ +AR+G++ + LL + L G TPL +AA+YG LDV + L+ R
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSL-----ATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
Query: 65 GASVEAGGS--------VHFDGETI----------------------------------- 81
A+ AG + H+D + +
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
Query: 82 --------------EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDG 127
+G PL AS GH D+V LL +GA+++ +T++ T L A +
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Query: 128 HLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
+ V L +H AD + + G+T L+++C+ G+ ++ +LL+QGA VN ++ G T L
Sbjct: 686 KVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 234
H A+ G I+ +LL A+ G T L A G+ ++V+ L
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 87.8 bits (216), Expect = 3e-17
Identities = 76/252 (30%), Positives = 116/252 (46%), Gaps = 16/252 (6%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D TA++ AA G ++ + LL R+ L G TPL IA + + V+E L
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF-----TPLHIACKKNRIKVMELL 396
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
V + GAS++A T G P+ A+ GHL++V LL+ GAS + T T L
Sbjct: 397 V-KYGASIQA--------ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A G +EVVR L+ + A ++ R T L I+ G EI + LL+ A + +
Sbjct: 448 HMAARAGQVEVVRCLL-RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
G T LH A G +++ +LL A G TPL A+ G ++ + L+Q +
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 240 GQEQVAGGEAQP 251
+ P
Sbjct: 567 AADSAGKNGLTP 578
Score = 84.7 bits (208), Expect = 2e-16
Identities = 71/241 (29%), Positives = 114/241 (47%), Gaps = 18/241 (7%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
+T ++ A+R GK +++Q LL + + G TPL I+AR G +DV L++
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPD-----AATTNGYTPLHISAREGQVDVASVLLE- 530
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
G+ H T +G PL A+ G LDV + LL+R A+ + + TPL A
Sbjct: 531 -------AGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
+ +V L+ E A ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 583 AHYDNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 641
Query: 184 NTALHDCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
T LH ++ G +++ LLL G M G+T L A+ N+ + L + Q
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-GLTSLHLAAQEDKVNVADILTKHGADQ 700
Query: 242 E 242
+
Sbjct: 701 D 701
Score = 45.8 bits (107), Expect = 1e-04
Identities = 45/177 (25%), Positives = 72/177 (40%), Gaps = 24/177 (13%)
Query: 445 VLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYL 504
VL + A SL T+ GF L G +V + L R DSA + + Y
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586
Query: 505 LEKVECTPSQEHLK-HQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 563
+KV ++ H T KNG+TPLH+A K+ + +
Sbjct: 587 NQKVALLLLEKGASPHATA----------KNGYTPLHIAAKKN-------------QMQI 623
Query: 564 VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
LL+ GA+ + TPLH+A+Q ++ L++ GA++ + T+ L
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 533 KNGFTPLHMAVDKDTTNV-----------------GRYPV---GRFPSLHVVKVLLDCGA 572
K+G T LH+A +D NV G P+ + ++ +V LL GA
Sbjct: 672 KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 731
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTA 617
+ +++ + TPLH AAQ I+N L++ GA +AT A TA
Sbjct: 732 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 18/110 (16%)
Query: 516 HLKHQTVYRLL---KCAP--RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V +LL + P R NGFTPLH+A K+ + V+++L+
Sbjct: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-------------IKVMELLVKY 399
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
GA + TP+H+AA I+ L++ GA D TN +TA +
Sbjct: 400 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
Score = 39.7 bits (91), Expect = 0.009
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 22/103 (21%)
Query: 533 KNGFTPLHMAV----------------DKDTTNV----GRYPVGRFPSLHVVKVLLDCGA 572
++G TP+H+A D TN+ + R + VV+ LL GA
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA--TNAF 613
D+R + TPLHIA++ I+ L++ AH DA TN +
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 510
Score = 38.9 bits (89), Expect = 0.016
Identities = 27/105 (25%), Positives = 51/105 (48%), Gaps = 21/105 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
++GFTPLH+A + +++V +LL+ GA D + TPLH+A++
Sbjct: 210 ESGFTPLHIAA-------------HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
Query: 593 CPAIMNALIEAGAHMDA--------TNAFKKTAYELLDEKLLARG 629
++ L++ G +DA + ++ ++ + E LL RG
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 301
Score = 38.1 bits (87), Expect = 0.026
Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 13/68 (19%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
KNG+TPLH A + T H++ VLL GA P++ + NT L IA +
Sbjct: 738 KNGYTPLHQAAQQGHT-------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 784
Query: 593 CPAIMNAL 600
++++ L
Sbjct: 785 YISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 103 bits (256), Expect = 7e-22
Identities = 160/674 (23%), Positives = 260/674 (38%), Gaps = 143/674 (21%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D + AAR G L + + L G ++ G L +AA+ GH+ +V+ L+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGI-----DINTCNQNGLNALHLAAKEGHVGLVQELL 84
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
R G+SV D T +G L AS AG +VV+ L++ GA++N ++ TPL
Sbjct: 85 GR-GSSV--------DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ------ 175
A + H++VV+YL+ E+ A+ A G T L ++ +GH + LLE +
Sbjct: 136 MAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 194
Query: 176 -------------------------------VNRRSAKGNTALHDCAESGSLEILQLLLG 204
VNR + G T LH A G++ + LLL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 205 CKARMERDG-YGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQG 263
A ++ G+TPL AS G+TN+V+ L+ GG Q D T G
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR--------GG-------QIDAKTRDG 299
Query: 264 CAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWR 323
PL+ C +R + +ELL +++ LL K+
Sbjct: 300 LT--------------PLH------C--AARSGHDQVVELL----LERGAPLLARTKNGL 333
Query: 324 RAMELRHQGG-----EYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIR 378
+ + QG ++L + + P + DY ++ R+ LL+
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC-------GHYRVTKLLLD 386
Query: 379 ERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLS 437
+R ++P+ + A N + + L KY +Q L+P+ ++F+
Sbjct: 387 KR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 438 FAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAI 497
+ +LQ+ A+ + G L G EV R L D+ +
Sbjct: 443 HLNIVLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDAR--AREEQT 499
Query: 498 ILHLLYLLEKVECTP-SQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGR---- 552
LH+ L K E +H+ H NG+TPLH++ + +V
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDA--------ATTNGYTPLHISAREGQVDVASVLLE 551
Query: 553 ----------------YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAI 596
+ ++ SL V K+LL A DS + TPLH+AA + +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 597 MNALIEAGAHMDAT 610
L+E GA AT
Sbjct: 612 ALLLLEKGASPHAT 625
Score = 97.4 bits (241), Expect = 4e-20
Identities = 76/288 (26%), Positives = 127/288 (44%), Gaps = 64/288 (22%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ +AR+G++ + LL + L G TPL +AA+YG LDV + L+ R
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSL-----ATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 65 GASVEAGGS--------VHFDGETI----------------------------------- 81
A+ AG + H+D + +
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 82 --------------EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDG 127
+G PL AS GH D+V LL +GA+++ +T++ T L A +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 128 HLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
+ V L +H AD + + G+T L+++C+ G+ ++ +LL+QGA VN ++ G T L
Sbjct: 707 KVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 234
H A+ G I+ +LL A+ G T L A G+ ++V+ L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 87.8 bits (216), Expect = 3e-17
Identities = 76/252 (30%), Positives = 116/252 (46%), Gaps = 16/252 (6%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D TA++ AA G ++ + LL R+ L G TPL IA + + V+E L
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF-----TPLHIACKKNRIKVMELL 417
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
V + GAS++A T G P+ A+ GHL++V LL+ GAS + T T L
Sbjct: 418 V-KYGASIQA--------ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A G +EVVR L+ + A ++ R T L I+ G EI + LL+ A + +
Sbjct: 469 HMAARAGQVEVVRCLL-RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
G T LH A G +++ +LL A G TPL A+ G ++ + L+Q +
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 240 GQEQVAGGEAQP 251
+ P
Sbjct: 588 AADSAGKNGLTP 599
Score = 84.7 bits (208), Expect = 2e-16
Identities = 71/241 (29%), Positives = 114/241 (47%), Gaps = 18/241 (7%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
+T ++ A+R GK +++Q LL + + G TPL I+AR G +DV L++
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPD-----AATTNGYTPLHISAREGQVDVASVLLE- 551
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
G+ H T +G PL A+ G LDV + LL+R A+ + + TPL A
Sbjct: 552 -------AGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
+ +V L+ E A ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 604 AHYDNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 184 NTALHDCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
T LH ++ G +++ LLL G M G+T L A+ N+ + L + Q
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-GLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 242 E 242
+
Sbjct: 722 D 722
Score = 45.8 bits (107), Expect = 1e-04
Identities = 45/177 (25%), Positives = 72/177 (40%), Gaps = 24/177 (13%)
Query: 445 VLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYL 504
VL + A SL T+ GF L G +V + L R DSA + + Y
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 505 LEKVECTPSQEHLK-HQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 563
+KV ++ H T KNG+TPLH+A K+ + +
Sbjct: 608 NQKVALLLLEKGASPHATA----------KNGYTPLHIAAKKN-------------QMQI 644
Query: 564 VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
LL+ GA+ + TPLH+A+Q ++ L++ GA++ + T+ L
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 533 KNGFTPLHMAVDKDTTNV-----------------GRYPV---GRFPSLHVVKVLLDCGA 572
K+G T LH+A +D NV G P+ + ++ +V LL GA
Sbjct: 693 KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 752
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTA 617
+ +++ + TPLH AAQ I+N L++ GA +AT A TA
Sbjct: 753 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 18/110 (16%)
Query: 516 HLKHQTVYRLL---KCAP--RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V +LL + P R NGFTPLH+A K+ + V+++L+
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-------------IKVMELLVKY 420
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
GA + TP+H+AA I+ L++ GA D TN +TA +
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Score = 39.7 bits (91), Expect = 0.009
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 22/103 (21%)
Query: 533 KNGFTPLHMAV----------------DKDTTNV----GRYPVGRFPSLHVVKVLLDCGA 572
++G TP+H+A D TN+ + R + VV+ LL GA
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA--TNAF 613
D+R + TPLHIA++ I+ L++ AH DA TN +
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Score = 38.9 bits (89), Expect = 0.016
Identities = 27/105 (25%), Positives = 51/105 (48%), Gaps = 21/105 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
++GFTPLH+A + +++V +LL+ GA D + TPLH+A++
Sbjct: 231 ESGFTPLHIAA-------------HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 593 CPAIMNALIEAGAHMDA--------TNAFKKTAYELLDEKLLARG 629
++ L++ G +DA + ++ ++ + E LL RG
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Score = 38.1 bits (87), Expect = 0.026
Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 13/68 (19%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
KNG+TPLH A + T H++ VLL GA P++ + NT L IA +
Sbjct: 759 KNGYTPLHQAAQQGHT-------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Query: 593 CPAIMNAL 600
++++ L
Sbjct: 806 YISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 103 bits (256), Expect = 7e-22
Identities = 160/674 (23%), Positives = 260/674 (38%), Gaps = 143/674 (21%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D + AAR G L + + L G ++ G L +AA+ GH+ +V+ L+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGI-----DINTCNQNGLNALHLAAKEGHVGLVQELL 84
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
R G+SV D T +G L AS AG +VV+ L++ GA++N ++ TPL
Sbjct: 85 GR-GSSV--------DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ------ 175
A + H++VV+YL+ E+ A+ A G T L ++ +GH + LLE +
Sbjct: 136 MAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP 194
Query: 176 -------------------------------VNRRSAKGNTALHDCAESGSLEILQLLLG 204
VNR + G T LH A G++ + LLL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 205 CKARMERDG-YGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQG 263
A ++ G+TPL AS G+TN+V+ L+ GG Q D T G
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR--------GG-------QIDAKTRDG 299
Query: 264 CAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWR 323
PL+ C +R + +ELL +++ LL K+
Sbjct: 300 LT--------------PLH------C--AARSGHDQVVELL----LERGAPLLARTKNGL 333
Query: 324 RAMELRHQGG-----EYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIR 378
+ + QG ++L + + P + DY ++ R+ LL+
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC-------GHYRVTKLLLD 386
Query: 379 ERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLW-KYALDMQQSNLEPLSPMTASSFLS 437
+R ++P+ + A N + + L KY +Q L+P+ ++F+
Sbjct: 387 KR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 438 FAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAI 497
+ +LQ+ A+ + G L G EV R L D+ +
Sbjct: 443 HLNIVLLLLQNGASPDVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDAR--AREEQT 499
Query: 498 ILHLLYLLEKVECTP-SQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGR---- 552
LH+ L K E +H+ H NG+TPLH++ + +V
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDA--------ATTNGYTPLHISAREGQVDVASVLLE 551
Query: 553 ----------------YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAI 596
+ ++ SL V K+LL A DS + TPLH+AA + +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 597 MNALIEAGAHMDAT 610
L+E GA AT
Sbjct: 612 ALLLLEKGASPHAT 625
Score = 97.4 bits (241), Expect = 4e-20
Identities = 76/288 (26%), Positives = 127/288 (44%), Gaps = 64/288 (22%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ +AR+G++ + LL + L G TPL +AA+YG LDV + L+ R
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSL-----ATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 65 GASVEAGGS--------VHFDGETI----------------------------------- 81
A+ AG + H+D + +
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 82 --------------EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDG 127
+G PL AS GH D+V LL +GA+++ +T++ T L A +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 128 HLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTAL 187
+ V L +H AD + + G+T L+++C+ G+ ++ +LL+QGA VN ++ G T L
Sbjct: 707 KVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 188 HDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 234
H A+ G I+ +LL A+ G T L A G+ ++V+ L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 87.8 bits (216), Expect = 3e-17
Identities = 76/252 (30%), Positives = 116/252 (46%), Gaps = 16/252 (6%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
+D TA++ AA G ++ + LL R+ L G TPL IA + + V+E L
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF-----TPLHIACKKNRIKVMELL 417
Query: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
V + GAS++A T G P+ A+ GHL++V LL+ GAS + T T L
Sbjct: 418 V-KYGASIQA--------ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
A G +EVVR L+ + A ++ R T L I+ G EI + LL+ A + +
Sbjct: 469 HMAARAGQVEVVRCLL-RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 181 AKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
G T LH A G +++ +LL A G TPL A+ G ++ + L+Q +
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 240 GQEQVAGGEAQP 251
+ P
Sbjct: 588 AADSAGKNGLTP 599
Score = 84.7 bits (208), Expect = 2e-16
Identities = 71/241 (29%), Positives = 114/241 (47%), Gaps = 18/241 (7%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
+T ++ A+R GK +++Q LL + + G TPL I+AR G +DV L++
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPD-----AATTNGYTPLHISAREGQVDVASVLLE- 551
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
G+ H T +G PL A+ G LDV + LL+R A+ + + TPL A
Sbjct: 552 -------AGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
+ +V L+ E A ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 604 AHYDNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 184 NTALHDCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
T LH ++ G +++ LLL G M G+T L A+ N+ + L + Q
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-GLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 242 E 242
+
Sbjct: 722 D 722
Score = 45.8 bits (107), Expect = 1e-04
Identities = 45/177 (25%), Positives = 72/177 (40%), Gaps = 24/177 (13%)
Query: 445 VLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYL 504
VL + A SL T+ GF L G +V + L R DSA + + Y
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 505 LEKVECTPSQEHLK-HQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 563
+KV ++ H T KNG+TPLH+A K+ + +
Sbjct: 608 NQKVALLLLEKGASPHATA----------KNGYTPLHIAAKKN-------------QMQI 644
Query: 564 VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
LL+ GA+ + TPLH+A+Q ++ L++ GA++ + T+ L
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 533 KNGFTPLHMAVDKDTTNV-----------------GRYPV---GRFPSLHVVKVLLDCGA 572
K+G T LH+A +D NV G P+ + ++ +V LL GA
Sbjct: 693 KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 752
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTA 617
+ +++ + TPLH AAQ I+N L++ GA +AT A TA
Sbjct: 753 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 18/110 (16%)
Query: 516 HLKHQTVYRLL---KCAP--RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDC 570
H H V +LL + P R NGFTPLH+A K+ + V+++L+
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-------------IKVMELLVKY 420
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYEL 620
GA + TP+H+AA I+ L++ GA D TN +TA +
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Score = 39.7 bits (91), Expect = 0.009
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 22/103 (21%)
Query: 533 KNGFTPLHMAV----------------DKDTTNV----GRYPVGRFPSLHVVKVLLDCGA 572
++G TP+H+A D TN+ + R + VV+ LL GA
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 573 DPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA--TNAF 613
D+R + TPLHIA++ I+ L++ AH DA TN +
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
Score = 38.9 bits (89), Expect = 0.016
Identities = 27/105 (25%), Positives = 51/105 (48%), Gaps = 21/105 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
++GFTPLH+A + +++V +LL+ GA D + TPLH+A++
Sbjct: 231 ESGFTPLHIAA-------------HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 593 CPAIMNALIEAGAHMDA--------TNAFKKTAYELLDEKLLARG 629
++ L++ G +DA + ++ ++ + E LL RG
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Score = 38.1 bits (87), Expect = 0.026
Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 13/68 (19%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
KNG+TPLH A + T H++ VLL GA P++ + NT L IA +
Sbjct: 759 KNGYTPLHQAAQQGHT-------------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Query: 593 CPAIMNAL 600
++++ L
Sbjct: 806 YISVVDTL 813
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 102 bits (255), Expect = 9e-22
Identities = 76/232 (32%), Positives = 114/232 (49%), Gaps = 20/232 (8%)
Query: 6 AVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCG 65
AVY AAR G + L+ L + ++ + +GE+A L +AARYGH DV + L
Sbjct: 415 AVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMA-----LHVAARYGHADVAQLLCS--- 466
Query: 66 ASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACF 125
G + + + E PL A+ G+ V ++L G +VN R TPL A
Sbjct: 467 ----FGSNPNIQDK--EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
Query: 126 DGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNT 185
G+ ++V L EH ADL ++ GH L ++ + E+ + LL QG V+ + GNT
Sbjct: 521 RGYHDIVECLA-EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 186 ALHDCAESGSLEILQLLLGCKARMERD---GYGMTPLLAASVTGHTNIVEYL 234
LH + G++ I+ L C+A D YG TPL A+ G ++V YL
Sbjct: 580 PLHVACKDGNMPIVVAL--CEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629
Score = 77.0 bits (188), Expect = 5e-14
Identities = 45/156 (28%), Positives = 84/156 (53%), Gaps = 4/156 (2%)
Query: 83 GAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQAD 142
G PPL A+ G++ +++ L++RG+ ++ + S + A GH++ +++L E++
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL-SENKCP 437
Query: 143 LEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLL 202
L+V ++ G L ++ GH ++A+ L G+ N + + T LH A G + + L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
Query: 203 --LGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQ 236
GC + ++ G TPLL AS G+ +IVE L +
Sbjct: 498 CEAGCNVNI-KNREGETPLLTASARGYHDIVECLAE 532
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/115 (29%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
K+G LH+AV R + V+K LL G D +D NTPLH+A ++
Sbjct: 542 KDGHIALHLAV-------------RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDG 588
Query: 593 CPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARAL 647
I+ AL EA ++D +N + +T L G + Y+ L + AL
Sbjct: 589 NMPIVVALCEANCNLDISNKYGRTPLHLAAN----NGILDVVRYLCLMGASVEAL 639
Score = 40.4 bits (93), Expect = 0.005
Identities = 36/128 (28%), Positives = 57/128 (44%), Gaps = 22/128 (17%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ K+G LH+A R+ V ++L G++P+ +D + TPLH AA
Sbjct: 441 KDKSGEMALHVAA-------------RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAW 487
Query: 591 NNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKN 650
+ ++ AL EAG +++ N +T LL ARG + ++CLA D N
Sbjct: 488 HGYYSVAKALCEAGCNVNIKNREGET--PLLTAS--ARG-----YHDIVECLAEHGADLN 538
Query: 651 KIPYKGFI 658
G I
Sbjct: 539 ACDKDGHI 546
Score = 35.8 bits (81), Expect = 0.13
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 13/88 (14%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
++G TPLH+A KD G P +V L + + D + TPLH+AA N
Sbjct: 575 RHGNTPLHVAC-KD---------GNMP---IVVALCEANCNLDISNKYGRTPLHLAANNG 621
Query: 593 CPAIMNALIEAGAHMDATNAFKKTAYEL 620
++ L GA ++A KTA +L
Sbjct: 622 ILDVVRYLCLMGASVEALTTDGKTAEDL 649
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 102 bits (254), Expect = 1e-21
Identities = 87/272 (31%), Positives = 128/272 (47%), Gaps = 25/272 (9%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++AA G L L L+ RE L + A G +PL +AAR+GH +VE+L+
Sbjct: 72 TPAHDAAATGSLAELCWLV----REGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE- 126
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLR-RGASVNRTTRTNSTPLRAA 123
G S ET EGA PL A+ +G L ++ L G+SVNR TR+ ++PL A
Sbjct: 127 ------GHSATL--ETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLA 178
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE-QGAQVNRRSAK 182
C +GHL + ++LV + AD+ + G + L + +GH + +L+ + R +
Sbjct: 179 CQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNE 238
Query: 183 GNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
G TALH A G IL LL + RD +G TPL A+ G + L+
Sbjct: 239 GATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSH----- 293
Query: 243 QVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCS 274
P L ED T+ A+ G C+
Sbjct: 294 -----HVDPSLRDEDGYTAADLAEYHGHRDCA 320
Score = 83.6 bits (205), Expect = 5e-16
Identities = 75/258 (29%), Positives = 112/258 (43%), Gaps = 39/258 (15%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC----- 64
AA+DG + L++LL + L + G G + A R GHLD V++LV R
Sbjct: 9 AAKDGDVATLERLLEAGA---LGPGITDALGAGL-VHHATRAGHLDCVKFLVQRAQLPGN 64
Query: 65 ----------------GASVEA-----GGSVHFDGETIEGAPPLWAASAAGHLDVVRSLL 103
G+ E G + G PL A+ GH +V LL
Sbjct: 65 QRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLL 124
Query: 104 RRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHR 163
G S TR + PL A G L ++ L H + + R G + L ++C +GH
Sbjct: 125 HEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHL 184
Query: 164 EIARYLLEQ-GAQVNRRSAKGNTALHDCAESGSLEILQLL-----LGCKARMERDGYGMT 217
+A++L++ GA V+ R+ G +ALH A G ++ L +G A RD G T
Sbjct: 185 HLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTA---RDNEGAT 241
Query: 218 PLLAASVTGHTNIVEYLI 235
L A+ GHT I++ L+
Sbjct: 242 ALHFAARGGHTPILDRLL 259
Score = 65.1 bits (157), Expect = 2e-10
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 32/191 (16%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
+++AA G L L KLL+ ++ T G +PL +A + GHL + ++LV CGA
Sbjct: 141 LHHAAVSGDLTCL-KLLTAAHGSSVNRRT---RSGASPLYLACQEGHLHLAQFLVKDCGA 196
Query: 67 SVE------------AGGSVHFD--------------GETIEGAPPLWAASAAGHLDVVR 100
V A H+ EGA L A+ GH ++
Sbjct: 197 DVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILD 256
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL G + R + TPL A +G +E + LV H D + + G+T ++ Y
Sbjct: 257 RLLLMGTPILRDS-WGGTPLHDAAENGQMECCQTLVSHH-VDPSLRDEDGYTAADLAEYH 314
Query: 161 GHREIARYLLE 171
GHR+ A+YL E
Sbjct: 315 GHRDCAQYLRE 325
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 99.8 bits (247), Expect = 7e-21
Identities = 76/248 (30%), Positives = 124/248 (50%), Gaps = 18/248 (7%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++ AA+ GKL++ LL + + G+ G TPL +AA Y + V L+D+
Sbjct: 567 TPLHVAAKYGKLEVANLLLQ---KSASPDAAGK--SGLTPLHVAAHYDNQKVALLLLDQ- 620
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
GAS A G PL A+ +D+ +LL GA N TR + A
Sbjct: 621 GASPHAAAK--------NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAA 672
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
+GH+++V L+G + A++ ++N+ G T L ++ + +A L+ QGA V+ ++ G
Sbjct: 673 QEGHVDMVSLLLGRN-ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
Query: 185 TALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE--QPGQ 241
T LH G+++I+ LL A++ + G TPL A+ GHT+I+ L+Q P +
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 242 EQVAGGEA 249
V G A
Sbjct: 792 LTVNGNTA 799
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/237 (31%), Positives = 120/237 (50%), Gaps = 16/237 (6%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D +T ++ +AR GK ++Q+LL + G TPL ++AR GH DV +L+
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPN-----AATTSGYTPLHLSAREGHEDVAAFLL 552
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
D GAS+ T +G PL A+ G L+V LL++ AS + ++ TPL
Sbjct: 553 DH-GASLSI--------TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
Query: 122 AACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSA 181
A + +V L+ + A A ++G+T L I+ K +IA LLE GA N +
Sbjct: 604 VAAHYDNQKVALLLL-DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 182 KGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
+G ++H A+ G ++++ LLLG A + + G+TPL A+ N+ E L+ +
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/269 (29%), Positives = 121/269 (44%), Gaps = 47/269 (17%)
Query: 2 DLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLV 61
D TA++ AA G ++ + LL ++ L G TPL IA + + V+E L+
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGF-----TPLHIACKKNRIKVMELLL 420
Query: 62 DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
GAS++A T G P+ A+ GH+++V L+ GAS N T T L
Sbjct: 421 KH-GASIQA--------VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH 471
Query: 122 AACFDGHLEVVRYLVGEH---------------------QADL-----------EVANRH 149
A G EVVRYLV + +AD+ A
Sbjct: 472 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 150 GHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM 209
G+T L +S +GH ++A +LL+ GA ++ + KG T LH A+ G LE+ LLL A
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 210 ERDG-YGMTPLLAASVTGHTNIVEYLIQE 237
+ G G+TPL A+ + + L+ +
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Score = 94.4 bits (233), Expect = 3e-19
Identities = 67/230 (29%), Positives = 108/230 (46%), Gaps = 16/230 (6%)
Query: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
++ A + L +Q LL + +D++T + T L +AA GH V + L+D+
Sbjct: 338 LHMATQGDHLNCVQLLL--QHNVPVDDVTNDYL---TALHVAAHCGHYKVAKVLLDK--- 389
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ + + + G PL A + V+ LL+ GAS+ T + TP+ A F
Sbjct: 390 ------KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GH+ +V L+ H A N G T L ++ G E+ RYL++ GAQV ++ T
Sbjct: 444 GHVNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
Query: 187 LHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLI 235
LH A G +I+Q LL A G TPL ++ GH ++ +L+
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL 552
Score = 91.3 bits (225), Expect = 3e-18
Identities = 138/633 (21%), Positives = 247/633 (39%), Gaps = 72/633 (11%)
Query: 13 DGKLQLLQKLLSGRSREELDELTGEV------AGGGTPLLIAARYGHLDVVEYLVDRCGA 66
D L+ +G + LD + V G L +A++ GH++VV L+ R
Sbjct: 40 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR--- 96
Query: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
+ D T +G L AS AG +VV+ L+ GA+VN ++ TPL A +
Sbjct: 97 ------EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
HLEVV++L+ ++ A +A G T L ++ +GH ++ LLE + R A
Sbjct: 151 NHLEVVKFLL-DNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRL----PA 205
Query: 187 LHDCAESGSLEILQLLLGCKARMERDG-YGMTPLLAASVTGHTNIVEYLIQEQPGQEQVA 245
LH A + LLL + + G TPL A+ G+ N+ L+ + A
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 246 GGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLG 305
+ P ++ +G A + + + +R + +E+L
Sbjct: 266 RNDITP----LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML- 320
Query: 306 ATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEELEAL-- 363
+D+ +L K+ + + QG QL+L ++ + T + L AL
Sbjct: 321 ---LDRAAPILSKTKNGLSPLHMATQGDHL----NCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 364 ITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIR-LWKYALDMQQS 422
++ +L+ ++ ++P+ + A N + + L K+ +Q
Sbjct: 374 AAHCGHYKVAKVLLDKK----ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 423 NLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLP 482
L+P+ ++F+ + S ++ A+ + + G L G EV R L
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR-GETALHMAARSGQAEVVR--YLV 486
Query: 483 REPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMA 542
++ K LH+ L K + + Q + + +G+TPLH++
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKAD-------IVQQLLQQGASPNAATTSGYTPLHLS 539
Query: 543 VDKD-----------------TTNVGRYPV---GRFPSLHVVKVLLDCGADPDSRDFDNN 582
+ TT G P+ ++ L V +LL A PD+
Sbjct: 540 AREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599
Query: 583 TPLHIAAQNNCPAIMNALIEAGA--HMDATNAF 613
TPLH+AA + + L++ GA H A N +
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 632
Score = 89.7 bits (221), Expect = 8e-18
Identities = 76/279 (27%), Positives = 122/279 (43%), Gaps = 49/279 (17%)
Query: 6 AVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCG 65
A++ AAR + LL + ++ E G TPL IAA YG+++V L++R
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADV-----ESKSGFTPLHIAAHYGNINVATLLLNRAA 259
Query: 66 ASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACF 125
A D PL AS G+ ++V+ LL RGA ++ TR TPL
Sbjct: 260 A---------VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310
Query: 126 DGHLEVVRYLV----------------------GEHQADLEVANRHG----------HTC 153
GH +VV L+ G+H +++ +H T
Sbjct: 311 SGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTA 370
Query: 154 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D 212
L ++ + GH ++A+ LL++ A N ++ G T LH + +++++LLL A ++
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 213 GYGMTPLLAASVTGHTNIVEYLIQE--QPGQEQVAGGEA 249
G+TP+ A+ GH NIV L+ P V G A
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 469
Score = 88.6 bits (218), Expect = 2e-17
Identities = 144/642 (22%), Positives = 248/642 (38%), Gaps = 95/642 (14%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T +Y AA++ L++++ LL + + L G TPL +A + GH VV L++
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSL-----ATEDGFTPLAVALQQGHDQVVSLLLEN- 195
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
+ G V P L A+ LL+ + + +++ TPL A
Sbjct: 196 ----DTKGKVRL--------PALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAA 243
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN 184
G++ V L+ A ++ R+ T L ++ +G+ + + LL++GA+++ ++ G
Sbjct: 244 HYGNINVATLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 185 TALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQ 243
T LH A SG +++++LL A + + G++PL A+ H N V+ L+Q +
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
Query: 244 VAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEP----LNGES-YESCCPTSREAAV 298
V + C + A P LNG + C +R +
Sbjct: 363 VTNDYLTA------LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 299 EALELLGATYVDKKRDLLGALK------HWRRAMELRHQGGEYLPKPEPPQLVLAYDYSR 352
E L GA+ L + H +L H G P + A +
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS--PNTTNVRGETALHMAA 474
Query: 353 EVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRL 412
E + L+ D ++ +A T +I R G + +L
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKA----------KDDQTPLHISAR------LGKADIVQQL 518
Query: 413 WKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGV 472
+ + +P+ S+ ++ +++L D A S+ T+ GF L G
Sbjct: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGK 577
Query: 473 REVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLK---CA 529
EV L D+A K+ LH+ H +Q V LL +
Sbjct: 578 LEVANLLLQKSASPDAAG--KSGLTPLHVA------------AHYDNQKVALLLLDQGAS 623
Query: 530 PRG--KNGFTPLHMAVDKDTTNVGRY---------PVGR--FPSLHV---------VKVL 567
P KNG+TPLH+A K+ ++ V R S+H+ V +L
Sbjct: 624 PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Query: 568 LDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDA 609
L A+ + + TPLH+AAQ + + L+ GAH+DA
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 725
Score = 87.0 bits (214), Expect = 5e-17
Identities = 62/195 (31%), Positives = 99/195 (50%), Gaps = 11/195 (5%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL IAA+ +D+ L++ GA A T +G + A+ GH+D+V
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEY-GADANA--------VTRQGIASVHLAAQEGHVDMVS 681
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
LL R A+VN + ++ TPL A + + V LV + A ++ + G+T L + C+
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHVDAQTKMGYTPLHVGCHY 740
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPL 219
G+ +I +LL+ A+VN ++ G T LH A+ G I+ +LL A E G T L
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 220 LAASVTGHTNIVEYL 234
A G+ ++V+ L
Sbjct: 801 GIARRLGYISVVDTL 815
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 13/167 (7%)
Query: 104 RRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHR 163
+R + + N++ LRAA GHLE + ++ D+ + N++G L ++ +GH
Sbjct: 30 KRSRDRKKKSDANASYLRAARA-GHLEKALDYI-KNGVDINICNQNGLNALHLASKEGHV 87
Query: 164 EIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAA 222
E+ LL++ A V+ + KGNTALH + +G E++++L+ A + G TPL A
Sbjct: 88 EVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147
Query: 223 SVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQG 269
+ H +V++L+ Q L ED T A QG
Sbjct: 148 AQENHLEVVKFLLDNGASQ----------SLATEDGFTPLAVALQQG 184
Score = 40.0 bits (92), Expect = 0.007
Identities = 28/91 (30%), Positives = 41/91 (45%), Gaps = 16/91 (17%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
K+G TPLH+A +D NV +VL++ GA D++ TPLH+
Sbjct: 695 KSGLTPLHLAAQEDRVNVA-------------EVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
Query: 593 CPAIMNALIEAGAHMDATNAFKKTAYELLDE 623
I+N L++ H NA K Y L +
Sbjct: 742 NIKIVNFLLQ---HSAKVNAKTKNGYTPLHQ 769
Score = 37.7 bits (86), Expect = 0.035
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 539 LHMAVDKDTTNV----GRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCP 594
+H +TTNV + R VV+ L+ GA +++ D+ TPLHI+A+
Sbjct: 453 MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKA 512
Query: 595 AIMNALIEAGAHMDATNAFKKTAYEL 620
I+ L++ GA +A T L
Sbjct: 513 DIVQQLLQQGASPNAATTSGYTPLHL 538
Score = 36.2 bits (82), Expect = 0.10
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 13/74 (17%)
Query: 527 KCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLH 586
K + KNG+TPLH A + T H++ VLL A P+ + NT L
Sbjct: 755 KVNAKTKNGYTPLHQAAQQGHT-------------HIINVLLQNNASPNELTVNGNTALG 801
Query: 587 IAAQNNCPAIMNAL 600
IA + ++++ L
Sbjct: 802 IARRLGYISVVDTL 815
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 98.2 bits (243), Expect = 2e-20
Identities = 80/241 (33%), Positives = 124/241 (51%), Gaps = 22/241 (9%)
Query: 1 MDLRTAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEY 59
+D TA+ +A+++G + ++++LL G + E D GG T L+ A G DVVE
Sbjct: 69 LDNWTALISASKEGHVHIVEELLKCGVNLEHRD------MGGWTALMWACYKGRTDVVEL 122
Query: 60 LVDRCGASVEAGG--SVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS 117
L+ GA+ G SV+ P +WAA GH D+V LL+ GA VN + + +
Sbjct: 123 LLSH-GANPSVTGLYSVY---------PIIWAAGR-GHADIVHLLLQNGAKVNCSDKYGT 171
Query: 118 TPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 177
TPL A GHLE V++L+ AD++ + T L+++ G+ + + +L++ VN
Sbjct: 172 TPLVWAARKGHLECVKHLLA-MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVN 230
Query: 178 RRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQ 236
GNTAL ++ G EI+Q LL + D G T L+ A GH IV L+Q
Sbjct: 231 LTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ 290
Query: 237 E 237
+
Sbjct: 291 K 291
Score = 87.4 bits (215), Expect = 4e-17
Identities = 68/235 (28%), Positives = 114/235 (48%), Gaps = 16/235 (6%)
Query: 6 AVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCG 65
+V N + + L+ LL E+ ++ G TPL+IAA G+L++V+ L+ G
Sbjct: 8 SVINYVEEENIPALKALL-----EKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN-G 61
Query: 66 ASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACF 125
A+ E ++ L +AS GH+ +V LL+ G ++ T L AC+
Sbjct: 62 ANCNL--------EDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACY 113
Query: 126 DGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNT 185
G +VV L+ H A+ V + ++ + +GH +I LL+ GA+VN G T
Sbjct: 114 KGRTDVVELLL-SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTT 172
Query: 186 ALHDCAESGSLEILQLLLGCKARMERDG-YGMTPLLAASVTGHTNIVEYLIQEQP 239
L A G LE ++ LL A ++++G MT L+ A G+T V+ +++ P
Sbjct: 173 PLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNP 227
Score = 74.7 bits (182), Expect = 3e-13
Identities = 66/224 (29%), Positives = 105/224 (46%), Gaps = 27/224 (12%)
Query: 41 GGTPLLIAARYGHLDVVEYL------VDRCGAS-------VEAGGSVHFDGETI------ 81
G TPL+ AAR GHL+ V++L VD+ GA+ GG E +
Sbjct: 170 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
Query: 82 -----EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLV 136
+G L AS GH ++V+ LL G VN R+ T L A GH+E+VR L+
Sbjct: 230 NLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALL 289
Query: 137 GEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSL 196
++ AD+++ + T L + KG+ + R +L+ + G T L + ++
Sbjct: 290 QKY-ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNI 348
Query: 197 EILQLLLGCKARMER-DGYGMTPLLAASVTGHTNIVEYLIQEQP 239
E+++LLL A++ D G TPL A + G + + L+ P
Sbjct: 349 EVVELLLDKGAKVSAVDKKGDTPLHIA-IRGRSRKLAELLLRNP 391
Score = 31.6 bits (70), Expect = 2.5
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 20/91 (21%)
Query: 531 RGKNGFTPLHMAVDK--------------DT---TNVGRYPV---GRFPSLHVVKVLLDC 570
RG++ T L+ AV+K DT T G P+ + ++ VV++LLD
Sbjct: 298 RGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDK 357
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALI 601
GA + D +TPLHIA + + L+
Sbjct: 358 GAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
Score = 29.6 bits (65), Expect = 9.4
Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 13/78 (16%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
R + G TPL +A ++ +L +VK L+ GA+ + D DN T L A++
Sbjct: 34 RNECGQTPLMIAAEQG-------------NLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 591 NNCPAIMNALIEAGAHMD 608
I+ L++ G +++
Sbjct: 81 EGHVHIVEELLKCGVNLE 98
Score = 29.6 bits (65), Expect = 9.4
Identities = 15/53 (28%), Positives = 25/53 (47%)
Query: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAF 613
+H+V+ LL CG + + RD T L A ++ L+ GA+ T +
Sbjct: 84 VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 96.3 bits (238), Expect = 8e-20
Identities = 97/330 (29%), Positives = 137/330 (41%), Gaps = 67/330 (20%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
T ++A+ G L LQ LLS D+ G T L +AAR+GH +VV +L+
Sbjct: 72 TPAHDASATGHLACLQWLLSQGGCRVQDKDNS----GATVLHLAARFGHPEVVNWLLHHG 127
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRR-GASVNRTTRTNSTPLRAA 123
G A T GA P+ A+A G +R L+ VN T+ +TPL A
Sbjct: 128 GGDPTAA--------TDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLA 179
Query: 124 CFDGHLEVVRYLVGEHQAD-----------LEVANRHGH--------------------- 151
C +GHLEV +YLV E AD L A + GH
Sbjct: 180 CQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKD 239
Query: 152 --TCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM 209
T + + +GH ++ +LL G +++ G T LHD AE+G LE Q+L+ A +
Sbjct: 240 GATAMHFAASRGHTKVLSWLLLHGGEIS-ADLWGGTPLHDAAENGELECCQILVVNGAEL 298
Query: 210 E-RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQ 268
+ RD G T + GH++ YL V + + DPS QP
Sbjct: 299 DVRDRDGYTAADLSDFNGHSHCTRYL-------RTVENLSVEHRVLSRDPSAELEAKQPD 351
Query: 269 GAPCCSSSPE-----EPLNGESYESCCPTS 293
SSP +PLN ++ PTS
Sbjct: 352 SG---MSSPNTTVSVQPLN---FDLSSPTS 375
Score = 65.5 bits (158), Expect = 2e-10
Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 18/199 (9%)
Query: 46 LIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRR 105
L AAR G LDV+ S+ A G + A P+ A+ AG L +R L+
Sbjct: 7 LQAARQGELDVLR--------SLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEE 58
Query: 106 GA-SVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHRE 164
A R +TP A GHL +++L+ + ++ + G T L ++ GH E
Sbjct: 59 AALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPE 118
Query: 165 IARYLLEQ-GAQVNRRSAKGNTALHDCAESGSLEILQLLL-----GCKARMERDGYGMTP 218
+ +LL G + G +H A G L+LL+ G A+ + G TP
Sbjct: 119 VVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKN---GATP 175
Query: 219 LLAASVTGHTNIVEYLIQE 237
L A GH + +YL+QE
Sbjct: 176 LYLACQEGHLEVTQYLVQE 194
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 12/58 (20%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
KNG TPL++A + V +Y ++ +CGADP +R D TPLH AAQ
Sbjct: 170 KNGATPLYLACQEGHLEVTQY------------LVQECGADPHARAHDGMTPLHAAAQ 215
Score = 30.8 bits (68), Expect = 4.2
Identities = 36/135 (26%), Positives = 48/135 (35%), Gaps = 28/135 (20%)
Query: 514 QEHLKHQTVYRLLKCAP----RGKNGFTPLHMAV----------------------DKDT 547
QE T Y + +C R +G TPLH A DKD
Sbjct: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
Query: 548 TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHM 607
+ R + + +LL G S D TPLH AA+N L+ GA +
Sbjct: 241 ATAMHFAASRGHTKVLSWLLLHGGEI--SADLWGGTPLHDAAENGELECCQILVVNGAEL 298
Query: 608 DATNAFKKTAYELLD 622
D + TA +L D
Sbjct: 299 DVRDRDGYTAADLSD 313
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 95.1 bits (235), Expect = 2e-19
Identities = 64/190 (33%), Positives = 97/190 (51%), Gaps = 12/190 (6%)
Query: 48 AARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGA 107
AAR G+L +++ L++ G V D G L A+ AGH+D VR L+ +GA
Sbjct: 19 AARRGNLALLKLLLN--------SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA 70
Query: 108 SVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIAR 167
+N + +T L A GH +VVR+L G A E + G T L+ + GH ++
Sbjct: 71 DINLQRESGTTALFFAAQQGHNDVVRFLFG-FGASTEFRTKDGGTALLAASQYGHMQVVE 129
Query: 168 YLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVT 225
LL+ GA ++ + G TAL A+ G L++++LLL G K R G PL AS
Sbjct: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQD-GTAPLWIASQM 188
Query: 226 GHTNIVEYLI 235
GH+ +V ++
Sbjct: 189 GHSEVVRVML 198
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/239 (32%), Positives = 120/239 (50%), Gaps = 17/239 (7%)
Query: 3 LRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVD 62
L A + AAR G L LL KLL R ++D G T L++AA GH+D V LV
Sbjct: 12 LANAAFWAARRGNLALL-KLLLNSGRVDVDCRDSH---GTTLLMVAAYAGHIDCVRELVL 67
Query: 63 RCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRA 122
+ G ++ E+ G L+ A+ GH DVVR L GAS T+ T L A
Sbjct: 68 Q-------GADINLQRES--GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLA 118
Query: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
A GH++VV L+ +H A++ G T L ++ G+ ++ R LL GA+VN+
Sbjct: 119 ASQYGHMQVVETLL-KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQD 177
Query: 183 GNTALHDCAESGSLEILQLLL--GCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
G L ++ G E+++++L G R+ G T LL A+ G+ ++++ L++ P
Sbjct: 178 GTAPLWIASQMGHSEVVRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSP 235
Score = 76.6 bits (187), Expect = 7e-14
Identities = 47/131 (35%), Positives = 71/131 (54%), Gaps = 5/131 (3%)
Query: 111 RTTRTNSTPLRAACF----DGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIA 166
R + TPL A F G+L +++ L+ + D++ + HG T LM++ Y GH +
Sbjct: 3 RMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCV 62
Query: 167 RYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVT 225
R L+ QGA +N + G TAL A+ G ++++ L G A E R G T LLAAS
Sbjct: 63 RELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQY 122
Query: 226 GHTNIVEYLIQ 236
GH +VE L++
Sbjct: 123 GHMQVVETLLK 133
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/176 (28%), Positives = 89/176 (50%), Gaps = 16/176 (9%)
Query: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
TA+ A++ G +Q+++ LL + + ++ G T L +AA+ G+LDV+ L+
Sbjct: 114 TALLAASQYGHMQVVETLLKHGAN-----IHDQLYDGATALFLAAQGGYLDVIRLLL--- 165
Query: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAAC 124
+G V+ + +G PLW AS GH +VVR +L RGA + +T L A
Sbjct: 166 ----ASGAKVNQPRQ--DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAA 219
Query: 125 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
G+ +V++ L+ + L + ++G + L + G+ + LLE GA + R+
Sbjct: 220 NKGYNDVIKELL-KFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 93.6 bits (231), Expect = 5e-19
Identities = 75/242 (30%), Positives = 117/242 (48%), Gaps = 20/242 (8%)
Query: 6 AVYNAARDGKLQLLQKLLSGRSREELDELTG-------EVAGGGTPLLIAARYGHLDVVE 58
AV+ +A G LQ + S + L E +G + +PL +AA +GH +E
Sbjct: 508 AVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE 567
Query: 59 YLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVN-RTTRTNS 117
LV + D G PL A+ GH++ V L+ +GAS+ +
Sbjct: 568 VLVQSL---------LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR 618
Query: 118 TPLRAACFDGHLEVVRYLVG--EHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ 175
TP+ AA +GH E +R L+G E Q +++ + +G T LM+S GH + LL +GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 176 VNRRSAKGNTALHDCAESGSLEILQLLLGCKAR-MERDGYGMTPLLAASVTGHTNIVEYL 234
V+ + G TALH A +G E + LL A+ + RD G TP+ ++ GH ++ L
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 235 IQ 236
+Q
Sbjct: 739 LQ 740
Score = 91.7 bits (226), Expect = 2e-18
Identities = 78/270 (28%), Positives = 117/270 (43%), Gaps = 49/270 (18%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
RT ++ AA +G + L+ L+ + ++ + G TPL+++ GH D V L+++
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDI--QDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
GA+V+A G L + GH + V +LL+ GA TP+ +
Sbjct: 676 -GANVDAKDKW--------GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLS 726
Query: 124 CFDGHLEVVRYLV---GEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQ-------- 172
GH+ V+ L+ A+ A+ HG+T L +CY GH LLEQ
Sbjct: 727 AACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG 786
Query: 173 -------------------------GAQ-VNRRSAKGNTALHDCAESGSLEILQLLLGCK 206
GA VN +KG T LH A + +E LQLLL
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN 846
Query: 207 ARMER-DGYGMTPLLAASVTGHTNIVEYLI 235
A++ D G TPL+ A+ G TN VE L+
Sbjct: 847 AQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 22/241 (9%)
Query: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
AA G Q L+ L+ + L +L + G TPL +AA GH++ V+ L+++ GAS+
Sbjct: 557 AAYHGHHQALEVLV-----QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ-GASIL 610
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTT---RTNSTPLRAACFD 126
+ I P+ AA+ GH + +R L+ N TPL + +
Sbjct: 611 VK-------DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLN 663
Query: 127 GHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTA 186
GH + V L+ + A+++ ++ G T L GH E LL+ GA+ R ++G T
Sbjct: 664 GHTDCVYSLLNKG-ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
Query: 187 LHDCAESGSLEILQLLLGCKARME-----RDGYGMTPLLAASVTGHTNIVEYLIQEQPGQ 241
+H A G + +L LL A M+ D +G T L A GH VE L++++ Q
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 242 E 242
+
Sbjct: 783 K 783
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/194 (31%), Positives = 99/194 (51%), Gaps = 11/194 (5%)
Query: 43 TPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSL 102
TPL AA G +++E L+ GA V A S + PL A A+ + V+ L
Sbjct: 43 TPLHAAAYLGDAEIIELLI-LSGARVNAKDS--------KWLTPLHRAVASCSEEAVQVL 93
Query: 103 LRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGH 162
L+ A VN + TPL A + ++ LV +++ V++R G T L + + GH
Sbjct: 94 LKHSADVNARDKNWQTPLHIAAANKAVKCAEALV-PLLSNVNVSDRAGRTALHHAAFSGH 152
Query: 163 REIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLA 221
E+ + LL +GA +N K A+H A G +E+++LL+ A + +D TPL A
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
Query: 222 ASVTGHTNIVEYLI 235
A+ +G ++V+YL+
Sbjct: 213 AASSGMISVVKYLL 226
Score = 77.4 bits (189), Expect = 4e-14
Identities = 58/185 (31%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 43 TPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSL 102
+PL A + E L+D GAS+ + +G PL AA+ H++ ++ L
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASI-------VNATDSKGRTPLHAAAFTDHVECLQLL 842
Query: 103 LRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGH 162
L A VN T TPL A +G V LV A+L + + +T L ++C KGH
Sbjct: 843 LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
Query: 163 REIARYLLEQGAQ---VNRRSAKGNTALHDCAESGSLEILQLLLGCKAR-MERDGYGMTP 218
A +LE+ +N +A T LH A +G ++Q LLG A + D G TP
Sbjct: 903 ETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Query: 219 LLAAS 223
LA +
Sbjct: 963 ALACA 967
Score = 73.2 bits (178), Expect = 7e-13
Identities = 64/233 (27%), Positives = 108/233 (46%), Gaps = 15/233 (6%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
R A++ AA G +++++ L+S + E+T + TPL AA G + VV+YL+D
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGA-----EVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228
Query: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
V + G PL A G VV L+ GA VN+ TPL A
Sbjct: 229 ---------GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Query: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
H + L+ + AD+ + ++ G T L ++ G ++ +++ GA ++ G
Sbjct: 280 AASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 339
Query: 184 NTALHDCAESGSLEILQLLLGCKARMERDG-YGMTPLLAASVTGHTNIVEYLI 235
NT LH A G ++ L+ A + G +GM PL A+++G ++ L+
Sbjct: 340 NTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Score = 65.9 bits (159), Expect = 1e-10
Identities = 66/243 (27%), Positives = 100/243 (41%), Gaps = 36/243 (14%)
Query: 5 TAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
T ++ AA G + +++ LL G E + A G TPL +A G VV L+D
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPN------AYGNTPLHVACYNGQDVVVNELID- 260
Query: 64 CGASVEAGGS-----VHFDGETIEGA---------------------PPLWAASAAGHLD 97
CGA V +HF + GA PL + G
Sbjct: 261 CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320
Query: 98 VVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMIS 157
+++++ GA ++ + +TPL A GH ++ L+ AD HG L ++
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIHGMFPLHLA 379
Query: 158 CYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM-ERDGYGM 216
G + R LL G ++ G T LH A G+LE L LLL A ++D +G
Sbjct: 380 ALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 439
Query: 217 TPL 219
+PL
Sbjct: 440 SPL 442
Score = 63.5 bits (153), Expect = 6e-10
Identities = 59/213 (27%), Positives = 91/213 (42%), Gaps = 14/213 (6%)
Query: 41 GGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVR 100
G TPL + A +G R +++G + D E G PL A+ GH ++
Sbjct: 306 GKTPLHMTALHGRFS-------RSQTIIQSGAVI--DCEDKNGNTPLHIAARYGHELLIN 356
Query: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
+L+ GA + PL A G + R L+ D++ + G TCL +
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG-FDIDTPDDFGRTCLHAAAAG 415
Query: 161 GHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM-ERDGYGMTPL 219
G+ E LL GA N++ G + LH A + + + L L+G A + + D G TPL
Sbjct: 416 GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
Query: 220 -LAASVTGHTNIVEYLIQE--QPGQEQVAGGEA 249
AA+ +EYL++ PG G A
Sbjct: 476 HYAATSDTDGKCLEYLLRNDANPGIRDKQGYNA 508
Score = 60.1 bits (144), Expect = 7e-09
Identities = 77/271 (28%), Positives = 108/271 (39%), Gaps = 47/271 (17%)
Query: 11 ARDGKLQLLQKLLSGR-SREELDELTGEVA-----GGGTPLLIAARYGHLDVVEYLVDRC 64
++DGK L L GR SR + +G V G TPL IAARYGH ++ L+
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS- 361
Query: 65 GASVEAGG-----------------------SVHFDGETIE--GAPPLWAASAAGHLDVV 99
GA G S FD +T + G L AA+A G+L+ +
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Query: 100 RSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCY 159
LL GA N+ + +PL A + + + + LVG A + + G T L +
Sbjct: 422 NLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG-ASVNDLDERGCTPLHYAAT 480
Query: 160 KG-HREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLG---CKARMERDGYG 215
+ YLL A R +G A+H A G LQL+ ME G
Sbjct: 481 SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD 540
Query: 216 M----------TPLLAASVTGHTNIVEYLIQ 236
M +PL A+ GH +E L+Q
Sbjct: 541 MLSDSDNRATISPLHLAAYHGHHQALEVLVQ 571
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ K +TPLH A + VVK LLD G D + + NTPLH+A
Sbjct: 202 KDKKSYTPLHAAASSGM-------------ISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Query: 591 NNCPAIMNALIEAGAHMDATN 611
N ++N LI+ GA ++ N
Sbjct: 249 NGQDVVVNELIDCGAIVNQKN 269
Score = 47.0 bits (110), Expect = 6e-05
Identities = 37/114 (32%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
A F+G + VR L+ + + D+ + T L + Y G EI L+ GA+VN + +K
Sbjct: 15 AIFNGDPDEVRALIFKKE-DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
Query: 183 GNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLI 235
T LH S S E +Q+LL A + RD TPL A+ E L+
Sbjct: 74 WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/256 (24%), Positives = 106/256 (41%), Gaps = 30/256 (11%)
Query: 4 RTAVYNAARDGKLQLLQKLLS-GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVD 62
RT ++ AA G L+ L LL+ G + D+ G +PL AA + + LV
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKF------GRSPLHYAAANCNYQCLFALVG 459
Query: 63 RCGASVEAGGSVHFDGETIEGAPPL-WAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLR 121
+G SV+ E G PL +AA++ + LLR A+ + +
Sbjct: 460 -------SGASVNDLDE--RGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVH 510
Query: 122 AACFDGHLEVVRYLVGEHQADL-----------EVANRHGHTCLMISCYKGHREIARYLL 170
+ GH ++ + E D+ + NR + L ++ Y GH + L+
Sbjct: 511 YSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLV 570
Query: 171 EQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGM--TPLLAASVTGHT 228
+ ++ R++ G T L A G +E + +L+ A + Y + TP+ AA+ GH+
Sbjct: 571 QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHS 630
Query: 229 NIVEYLIQEQPGQEQV 244
+ LI Q V
Sbjct: 631 ECLRLLIGNAEPQNAV 646
Score = 40.8 bits (94), Expect = 0.004
Identities = 27/75 (36%), Positives = 38/75 (50%), Gaps = 13/75 (17%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQ 590
+ K+G TPLHM T GR+ + ++ GA D D + NTPLHIAA+
Sbjct: 302 KSKDGKTPLHM-----TALHGRFSRSQ--------TIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 591 NNCPAIMNALIEAGA 605
++N LI +GA
Sbjct: 349 YGHELLINTLITSGA 363
Score = 40.0 bits (92), Expect = 0.007
Identities = 19/56 (33%), Positives = 33/56 (58%)
Query: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT 616
+ VVK+L+ GA+ +D + TPLH AA + +++ L++ G M+ NA+ T
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNT 241
Score = 37.0 bits (84), Expect = 0.059
Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 13/81 (16%)
Query: 537 TPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAI 596
TPLH AV S V+VLL AD ++RD + TPLHIAA N
Sbjct: 76 TPLHRAVASC-------------SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC 122
Query: 597 MNALIEAGAHMDATNAFKKTA 617
AL+ ++++ ++ +TA
Sbjct: 123 AEALVPLLSNVNVSDRAGRTA 143
Score = 37.0 bits (84), Expect = 0.059
Identities = 24/84 (28%), Positives = 36/84 (42%), Gaps = 13/84 (15%)
Query: 533 KNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
KNG TPLH+A R+ ++ L+ GAD R PLH+AA +
Sbjct: 337 KNGNTPLHIAA-------------RYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Query: 593 CPAIMNALIEAGAHMDATNAFKKT 616
L+ +G +D + F +T
Sbjct: 384 FSDCCRKLLSSGFDIDTPDDFGRT 407
Score = 34.7 bits (78), Expect = 0.29
Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 26/110 (23%)
Query: 531 RGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLH---VVKVLLDCGADPDSRDFDNNTPLHI 587
+ + GFTPLH A S H +++L+ GAD + + D TPLH+
Sbjct: 268 KNEKGFTPLHFAA---------------ASTHGALCLELLVGNGADVNMKSKDGKTPLHM 312
Query: 588 AAQNNCPAIMNALIEAGAHMDATNAFKKT--------AYELLDEKLLARG 629
A + + +I++GA +D + T +ELL L+ G
Sbjct: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Score = 34.3 bits (77), Expect = 0.38
Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 20/100 (20%)
Query: 529 APRGKNGFTPLHMAV----------------DKDTTN-VGR---YPVGRFPSLHVVKVLL 568
A RG +G PLH+A D DT + GR + +L + +LL
Sbjct: 366 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 425
Query: 569 DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMD 608
+ GAD + +D +PLH AA N + AL+ +GA ++
Sbjct: 426 NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Score = 32.3 bits (72), Expect = 1.5
Identities = 18/49 (36%), Positives = 26/49 (53%)
Query: 564 VKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNA 612
V LL GA RD TP+H++A ++ AL+++ A MDA A
Sbjct: 702 VDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPA 750
Score = 30.4 bits (67), Expect = 5.5
Identities = 32/115 (27%), Positives = 44/115 (38%), Gaps = 25/115 (21%)
Query: 534 NGFTPLHMAVDKDTTNVGRYPV--------------GRFPSLHV---------VKVLLDC 570
N F+PLH AV D + GR P LH +++LL
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP-LHAAAFTDHVECLQLLLSH 845
Query: 571 GADPDSRDFDNNTPLHIAAQNNCPAIMNALI-EAGAHMDATNAFKKTAYELLDEK 624
A +S D TPL +AA+N + L+ A A + + K TA L K
Sbjct: 846 NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
Length = 304
Score = 91.3 bits (225), Expect = 3e-18
Identities = 78/231 (33%), Positives = 114/231 (49%), Gaps = 22/231 (9%)
Query: 17 QLLQKLLSGRSREELDELTGEVAGGGTP-------LLIAARYGHLDVVEYLVDRCGASVE 69
+L + + GR R +EL A GG P L AAR+GH DV+ YL + G +E
Sbjct: 9 RLCRLVQEGRLRALKEELQ---AAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIE 65
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A + PL A++ GH D VR LL RGA+V+ + + TPL AC +L
Sbjct: 66 ATNRDY--------KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNL 117
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK-GNTALH 188
V++ LV EH A+ + N+ G I+ +G I +YLL + +K T LH
Sbjct: 118 GVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
Query: 189 DCAESGSLEILQLLL-GCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
A G LE +++LL C+ + RD G+T L+ A GH ++ L+ E
Sbjct: 177 TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/185 (29%), Positives = 81/185 (43%), Gaps = 23/185 (12%)
Query: 22 LLSGRSREELDELTGEVAGGGTPLL----------IAARYGHLDVVEYLVDRCGASVEAG 71
L+ +R+ L + V G PLL IA+R G +++YL+ C + +
Sbjct: 108 LMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE 167
Query: 72 GSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS--TPLRAACFDGHL 129
+ PL A+ GHL+ V+ LL+R R N T L A GH+
Sbjct: 168 SKIR--------RTPLHTAAMHGHLEAVKVLLKR-CQYEPDYRDNCGVTALMDAIQCGHI 218
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL-EQGAQVNRRSAKGN-TAL 187
+V R L+ EH A L + G L + G E R+L+ E G V+ R+ + TAL
Sbjct: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
Query: 188 HDCAE 192
H A+
Sbjct: 279 HYAAK 283
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 91.3 bits (225), Expect = 3e-18
Identities = 78/231 (33%), Positives = 114/231 (49%), Gaps = 22/231 (9%)
Query: 17 QLLQKLLSGRSREELDELTGEVAGGGTP-------LLIAARYGHLDVVEYLVDRCGASVE 69
+L + + GR R +EL A GG P L AAR+GH DV+ YL + G +E
Sbjct: 9 RLCRLVQEGRLRALKEELQ---AAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIE 65
Query: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
A + PL A++ GH D VR LL RGA+V+ + + TPL AC +L
Sbjct: 66 ATNRDY--------KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNL 117
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK-GNTALH 188
V++ LV EH A+ + N+ G I+ +G I +YLL + +K T LH
Sbjct: 118 GVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
Query: 189 DCAESGSLEILQLLL-GCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
A G LE +++LL C+ + RD G+T L+ A GH ++ L+ E
Sbjct: 177 TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
Score = 63.5 bits (153), Expect = 6e-10
Identities = 69/245 (28%), Positives = 104/245 (42%), Gaps = 25/245 (10%)
Query: 22 LLSGRSREELDELTGEVAGGGTPLL----------IAARYGHLDVVEYLVDRCGASVEAG 71
L+ +R+ L + V G PLL IA+R G +++YL+ C + +
Sbjct: 108 LMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE 167
Query: 72 GSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS--TPLRAACFDGHL 129
+ PL A+ GHL+ V+ LL+R R N T L A GH+
Sbjct: 168 SKIR--------RTPLHTAAMHGHLEAVKVLLKR-CQYEPDYRDNCGVTALMDAIQCGHI 218
Query: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL-EQGAQVNRRSAKGN-TAL 187
+V R L+ EH A L + G L + G E R+L+ E G V+ R+ + TAL
Sbjct: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
Query: 188 HDCAESGSLEILQLLLGCKARM-ERDGYGMTPLLAASVTGHTNIVEYLIQE-QPGQEQVA 245
H A+ G +Q LL A + +D + L A H ++L+Q E +
Sbjct: 279 HYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
Query: 246 GGEAQ 250
G AQ
Sbjct: 339 GTLAQ 343
Score = 45.8 bits (107), Expect = 1e-04
Identities = 44/168 (26%), Positives = 65/168 (38%), Gaps = 31/168 (18%)
Query: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
RT ++ AA G L+ ++ LL R + E D G T L+ A + GH+DV L+D
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLK-RCQYEPDYRDN---CGVTALMDAIQCGHIDVARLLLDE 227
Query: 64 CGASVEAGGSVHFDG---------------------------ETIEGAPPLWAASAAGHL 96
GA + A S+ T L A+ GH
Sbjct: 228 HGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHT 287
Query: 97 DVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLE 144
+++LL GA +N N + L AC HL ++L+ D E
Sbjct: 288 STIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
Score = 30.8 bits (68), Expect = 4.2
Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 13/112 (11%)
Query: 502 LYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSL 561
L L E C +++ L Q ++R F + VD D + +L
Sbjct: 223 LLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH----LTAL 278
Query: 562 H---------VVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAG 604
H ++ LL GAD +S+D N + LH+A A L+++G
Sbjct: 279 HYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,787,429
Number of Sequences: 37866
Number of extensions: 1288965
Number of successful extensions: 9070
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 340
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 3795
Number of HSP's gapped (non-prelim): 2711
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.