Search of human proteins with 24233530

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
         (919 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                  1861   0.0  
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                  1270   0.0  
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                 1141   0.0  
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       327   4e-89
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        327   4e-89
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        327   4e-89
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        327   4e-89
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        327   4e-89
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       305   1e-82
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        305   1e-82
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        305   1e-82
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   303   5e-82
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        300   3e-81
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   248   1e-65
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   238   2e-62
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   237   3e-62
gi|34304381 inversin isoform a [Homo sapiens]                         215   2e-55
gi|34304379 inversin isoform b [Homo sapiens]                         215   2e-55
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   185   1e-46
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   180   6e-45
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    180   6e-45
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   173   6e-43
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    172   1e-42
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    170   5e-42
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   167   3e-41
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   167   5e-41
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   166   7e-41
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          159   1e-38
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        159   1e-38
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   157   4e-38

>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 1861 bits (4821), Expect = 0.0
 Identities = 919/919 (100%), Positives = 919/919 (100%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
           HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
           DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
           LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
           ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600

Query: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
           IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660

Query: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720
           VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720

Query: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF 780
           RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF
Sbjct: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF 780

Query: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
           TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840

Query: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
           NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900

Query: 901 LDKIQDESLINEKNNALQT 919
           LDKIQDESLINEKNNALQT
Sbjct: 901 LDKIQDESLINEKNNALQT 919


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 1270 bits (3287), Expect = 0.0
 Identities = 635/929 (68%), Positives = 741/929 (79%), Gaps = 38/929 (4%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           LI K EDVN  D+EKRTPLH AA+LGDAEIIELLILSGARVNAKD+ WLTPLHRAVAS S
Sbjct: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
           EEAVQVL+KHSADVNARDKNWQTPLH+AAANKAVKCAE ++PLLS+VNVSDR GRTALHH
Sbjct: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
           AA +GH EMV LLL++GANINAFDKKDRRA+HWAAYMGH++VV LL++HGAEVTCKDKK 
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
           YTPLHAAAS+G I+VVK+LL+LGV+++E N YGNT LH+ACYNGQD VVNELID GA VN
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
           Q N  GFTPLHFAAASTHGALCLELLV NGADVN++SKDGK+PLHMTA+HGRF+RSQT+I
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326

Query: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
           Q+G  IDC DK+GNTPLH+AARYGHELLINTL TSGADTAK GIH MFPLHLAAL+  SD
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
           CCRKLLSSGF+IDTPD FGRTCLHAAAAGGN+EC+ LL ++GADF+KKDK GR+PLHYAA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
           ANC++ C+  LV +GA+VN+ D+ G T LHYAA SD D                      
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK-------------------- 486

Query: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT-------NSGF 534
                  CLE+LL+NDANP IRDK+GYN++HY+AAYGHR CL+L+   T        SG 
Sbjct: 487 -------CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539

Query: 535 E---ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591
           +   +SD+ AT SPLHLAAY+GHHQALEVL+QSL+DLD+R+  GRT LDLAAFKGH ECV
Sbjct: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599

Query: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
           + LIN GASI VKD + KRTP+HA+  NGH+ CLRLL+  A+   AVD++D  GQTPLML
Sbjct: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           +V  GH D V  LL K ANVD  D  G TALHRG +TGHEECV  LL+     L +DSRG
Sbjct: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719

Query: 712 RTPLHYAAARGHATWLSELLQMALS-EEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770
           RTP+H +AA GH   L  LLQ A S + +    DN GYT LHWACYNG+E C+E+LLEQ+
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779

Query: 771 CFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
            F+K  GN F+PLHCA+IND+   A +L+  + +SIV+  D KGRTPL AAAF DHVECL
Sbjct: 780 VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839

Query: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACS 890
           QLLL H+A VN+VD++GKT LMMAAENGQ   V++LV+SA A+LT++D   NT LHLACS
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899

Query: 891 KGHEKCALLILDKIQDESLINEKNNALQT 919
           KGHE  ALLIL+KI D +LIN  N ALQT
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQT 928



 Score =  319 bits (817), Expect = 9e-87
 Identities = 248/767 (32%), Positives = 356/767 (46%), Gaps = 62/767 (8%)

Query: 147 KDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206
           +D+ +L  A + G  D V  LI    +V  +D +  TPLHAAA  G   +++ L+  G  
Sbjct: 7   RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66

Query: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLEL 266
           ++  +    T LH A  +  +  V  L+ + A+VN  + N  TPLH AAA+     C E 
Sbjct: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAAN-KAVKCAEA 125

Query: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326
           LV   ++VN+  + G++ LH  A  G     + L+  G  I+  DK     +H AA  GH
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185

Query: 327 ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHA 386
             ++  L + GA+       S  PLH AA +      + LL  G +++ P+ +G T LH 
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH-FHCIETLVTTGANVNETDDW 445
           A   G    +  L   GA  ++K++ G TPLH+AAA+ H   C+E LV  GA+VN     
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 446 GRTALHYAAA-SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504
           G+T LH  A      R++TI                             +Q+ A     D
Sbjct: 306 GKTPLHMTALHGRFSRSQTI-----------------------------IQSGAVIDCED 336

Query: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA-TKSPLHLAAYNGHHQALEVLLQ 563
           K G   +H AA YGH   +  L+    SG + +  G     PLHLAA +G       LL 
Sbjct: 337 KNGNTPLHIAARYGHELLINTLI---TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393

Query: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623
           S  D+D  D+ GRT L  AA  G+ EC+  L+N GA    KD    R+PLH +  N +  
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF-GRSPLHYAAANCNYQ 452

Query: 624 CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL--LLEKEANVDTVDILGCTA 681
           C   L  +  +  +V+  D +G TPL  A A    D   L  LL  +AN    D  G  A
Sbjct: 453 C---LFALVGSGASVNDLDERGCTPLHYA-ATSDTDGKCLEYLLRNDANPGIRDKQGYNA 508

Query: 682 LHRGIMTGHEECVQM---------LLEQEVSILCKDSRGR---TPLHYAAARGHATWLSE 729
           +H     GH  C+Q+         L+E   + +  DS  R   +PLH AA  GH   L  
Sbjct: 509 VHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEV 568

Query: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAI 787
           L+Q  L   D   +++ G TPL  A + G+  C++VL+ Q      K      TP+H A 
Sbjct: 569 LVQSLL---DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625

Query: 788 INDHGNCASLLLG-AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
            N H  C  LL+G A   + V  +D  G+TPL  +    H +C+  LL   A V+A D  
Sbjct: 626 TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW 685

Query: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
           G+TAL   A  G    VD L+    A   ++D    TP+HL+ + GH
Sbjct: 686 GRTALHRGAVTGHEECVDALLQHG-AKCLLRDSRGRTPIHLSAACGH 731


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 1141 bits (2951), Expect = 0.0
 Identities = 572/936 (61%), Positives = 704/936 (75%), Gaps = 19/936 (2%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+ + E++N LD E+RTPLH AA++GD  I++LL++SGA VNAKD +WLTPLHRA ASR+
Sbjct: 27  LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRN 86

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
           E+ + +L+ HSADVNARDK WQTPLHVAAAN+A KCAE + PLLSS+NV+DR GR+ALHH
Sbjct: 87  EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHH 146

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
           A  +GH+E VNLLL KGA++N  DKK+R+ LHWAA++GHL+V+ LL+  GA++ CKD+KG
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206

Query: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
           Y  LH AA++GQI VVK+LL +G EIDE N +GNTALHIACY GQDAV  EL++ GANVN
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266

Query: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
           QPN+ GFTPLH AA ST+GALCLELLVNNGADVN QSK+GKSPLHM A+HGRFTRSQ LI
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326

Query: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
           QNG EIDC DK GNTPLHVAARYGHELLI+TL T+GADTA+ GIH MFPLHLA L   SD
Sbjct: 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386

Query: 362 CCRKLLSS------------------GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403
           CCRKLLSS                  GF+I+TPD  GRTCLHAAA+GGNVEC+ LL SSG
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKT 463
           AD  ++DK GRTPLHYAAAN  + C  TLVT GA VNE D  G + LHYAAASD  R   
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506

Query: 464 ILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCL 523
               +  ++EE E  +E + KEA  CLEFLL N A+PS+RD++GY ++HYAAAYG+RQ L
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566

Query: 524 ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
           ELLLE + +  E+ +S    SPLHLAAYNGH +AL+ L ++LV+LD+RD KGRTAL LA 
Sbjct: 567 ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT 626

Query: 584 FKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643
            +G TECVE L   GAS  +K+   K TPLHA+  +GHT  L LL++  +  +  DV DA
Sbjct: 627 ERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDA 686

Query: 644 KGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
            GQTPLMLA+  GH+D V LLLEK +  D  D+ G TALHRG +TG E+C+  LL+ +  
Sbjct: 687 YGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746

Query: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC-CFKDNQGYTPLHWACYNGNENC 762
           +LC+D +GRTP+H A+A GH   L  LLQ ALS +      D  GY+P+HWA Y G+E+C
Sbjct: 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806

Query: 763 IEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822
           +E+LLE   F    GNPFTPLHCA+IN+  +   +LLGA+ + IV+ RD KGRTPL AAA
Sbjct: 807 LELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866

Query: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
           FAD+V  L++LL+H A VNA D++G+TALM AAENGQ  AV+ L+   +ADLTV D++ N
Sbjct: 867 FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN 926

Query: 883 TPLHLACSKGHEKCALLILDKIQDESLINEKNNALQ 918
           T LHLACSKGHEKCAL+IL + QD  LIN  N+ALQ
Sbjct: 927 TALHLACSKGHEKCALMILAETQDLGLINATNSALQ 962



 Score =  266 bits (679), Expect = 9e-71
 Identities = 219/774 (28%), Positives = 341/774 (44%), Gaps = 97/774 (12%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH-RAVASR 60
           L+    +++  ++   T LH+A +LG   +   L+ +GA VN  ++   TPLH  AV++ 
Sbjct: 225 LLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 284

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
               +++L+ + ADVN + K  ++PLH+AA +     ++++I   S ++ +D+ G T LH
Sbjct: 285 GALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLH 344

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLD-------------VVALL 167
            AA  GH  +++ L+  GA+       D   LH A   G  D             +V+ L
Sbjct: 345 VAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSL 404

Query: 168 INH-----GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIAC 222
            N      G ++   D  G T LHAAAS G +  +  LL+ G ++   + +G T LH A 
Sbjct: 405 SNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAA 464

Query: 223 YNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS------------THGA--------- 261
            NG       L+  GA VN+ +  G +PLH+AAAS            +H A         
Sbjct: 465 ANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKES 524

Query: 262 ------LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
                  CLE L++NGAD +++ + G + +H  A +G     + L++     +C++   +
Sbjct: 525 RRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS--FNCLEDVES 582

Query: 316 T----PLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
           T    PLH+AA  GH   + TL  +  +           L LA     ++C   L + G 
Sbjct: 583 TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642

Query: 372 EIDTPDKFGR-TCLHAAAAGGNVECIKLLQSSG--ADFHK-KDKCGRTPLHYAAANCHFH 427
                ++  + T LHAAAA G+ + + LL  SG  AD     D  G+TPL  A  N H  
Sbjct: 643 SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVD 702

Query: 428 CIETLVTTGANVNETDDWGRTALHYAA--------ASDMDRNKTILGNAHDNSEELERAR 479
           C+  L+  G+  +  D  GRTALH  A        A+ +D +  +L         +  A 
Sbjct: 703 CVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS 762

Query: 480 ELKEKEAT-LCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEE-- 536
                      L+  L  D   +  D  GY+ +H+A+  GH  CLELLLE +   + E  
Sbjct: 763 ACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGN 822

Query: 537 ------------------------------SDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
                                         S     ++PLH AA+  +   L +LLQ   
Sbjct: 823 PFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQA 882

Query: 567 DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLR 626
           +++  D  GRTAL  AA  G T  VE L+  G +     +  K T LH +   GH  C  
Sbjct: 883 EVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCAL 942

Query: 627 LLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
           ++L    +   ++  ++  Q PL +A   G    V  LL   A V  VD  G T
Sbjct: 943 MILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996



 Score =  261 bits (668), Expect = 2e-69
 Identities = 238/845 (28%), Positives = 369/845 (43%), Gaps = 100/845 (11%)

Query: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207
           D+  L  A +   ++ V  L++    +   D++  TPLHAAA  G + +++ LL  G  +
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
           +  +    T LH A  +  + V+  L+ + A+VN  +    TPLH AAA+     C E L
Sbjct: 68  NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAAN-RATKCAEAL 126

Query: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327
               + +N+  + G+S LH     G       L+  G  ++  DK    PLH AA  GH 
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL 186

Query: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387
            ++  L   GAD           LH AA +   +  + LL  G EID P+ FG T LH A
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246

Query: 388 A-------------AGGNVE---------------------CIKLLQSSGADFHKKDKCG 413
                         AG NV                      C++LL ++GAD + + K G
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306

Query: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA--------------ASDMD 459
           ++PLH AA +  F   + L+  G+ ++  D +G T LH AA               +D  
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 366

Query: 460 R---------NKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510
           R         +  +L    D   +L  + +L    ++L  E +L    + +  D  G   
Sbjct: 367 RRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTC 426

Query: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
           +H AA+ G+ +CL LLL  + +     D    ++PLH AA NG +Q    L+ +   ++ 
Sbjct: 427 LHAAASGGNVECLNLLLS-SGADLRRRDKFG-RTPLHYAAANGSYQCAVTLVTAGAGVNE 484

Query: 571 RDEKGRTALDLAA-------FKGHTE---------------------CVEALINPGASIF 602
            D KG + L  AA        + HT                      C+E L++ GA   
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544

Query: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
           ++D     T +H +   G+   L LLLE++ N    DV+     +PL LA   GH +A+ 
Sbjct: 545 LRDR-QGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALK 602

Query: 663 LLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAAR 721
            L E   N+D  D  G TAL      G  ECV++L     S L K+ + + TPLH AAA 
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662

Query: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPF 780
           GH   L  L+      +     D  G TPL  A  NG+ +C+ +LLE+            
Sbjct: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722

Query: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR---HS 837
           T LH   +    +C + LL     + V CRD KGRTP+  A+   H   L+ LL+    +
Sbjct: 723 TALHRGAVTGCEDCLAALLD--HDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALST 780

Query: 838 APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            P++A VD SG + +  A+  G    +++L+    +  +  + +  TPLH A     +  
Sbjct: 781 DPLDAGVDYSGYSPMHWASYTGHEDCLELLLE--HSPFSYLEGNPFTPLHCAVINNQDST 838

Query: 897 ALLIL 901
             ++L
Sbjct: 839 TEMLL 843



 Score =  107 bits (268), Expect = 4e-23
 Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 13/268 (4%)

Query: 13   DSEKRTPLHVAAFLGDAEIIELLILSGARVN----AKDNMWLTPLHRAVASRSEEAVQVL 68
            D + RTP+H+A+  G   ++  L+ +    +      D    +P+H A  +  E+ +++L
Sbjct: 751  DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810

Query: 69   IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS--VNVSDRGGRTALHHAALNG 126
            ++HS   +  + N  TPLH A  N      E+++  L +  VN  D  GRT LH AA   
Sbjct: 811  LEHSP-FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869

Query: 127  HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG-AEVTCKDKKGYTPL 185
            +V  + +LL   A +NA D   R AL  AA  G    V  L+  G A++T  D+   T L
Sbjct: 870  NVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929

Query: 186  HAAASNGQ----INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
            H A S G     + ++    +LG+ I+  N      LHIA  NG  +VV  L+ +GA V 
Sbjct: 930  HLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSHGATVL 988

Query: 242  QPNNNGFTPLHFAAASTHGALCLELLVN 269
              +  G TP    A +   A CL L+++
Sbjct: 989  AVDEEGHTPALACAPNKDVADCLALILS 1016



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 63/189 (33%), Positives = 94/189 (49%), Gaps = 6/189 (3%)

Query: 12   LDSEKRTPLHVAAFLGDAEIIELLI--LSGARVNAKDNMWLTPLHRAVASRSEEAVQVLI 69
            L+    TPLH A         E+L+  L    VN++D    TPLH A  + +   +++L+
Sbjct: 819  LEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLL 878

Query: 70   KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPL-LSSVNVSDRGGRTALHHAALNGHV 128
            +H A+VNA D   +T L  AA N      E ++    + + V D    TALH A   GH 
Sbjct: 879  QHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHE 938

Query: 129  EMVNLLLAKGAN---INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
            +   ++LA+  +   INA +   +  LH AA  G   VV  L++HGA V   D++G+TP 
Sbjct: 939  KCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998

Query: 186  HAAASNGQI 194
             A A N  +
Sbjct: 999  LACAPNKDV 1007


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  327 bits (837), Expect = 4e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106

Query: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 222

Query: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281

Query: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341

Query: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 451

Query: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 452 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 491

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 551

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 552 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 605

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 666 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 723 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 781 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 834



 Score =  314 bits (804), Expect = 3e-85
 Identities = 248/761 (32%), Positives = 356/761 (46%), Gaps = 51/761 (6%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 170

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N+ ++DG +PL +    G       LI  G +     K     LH+AAR         L 
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 226

Query: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
            +  +          PLH+AA   + +  + LL+ G  ++   + G T LH A+  GNV 
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 286

Query: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
            ++LL   GA    K K   TPLH AA N H    E L+  GA +      G + +H AA
Sbjct: 287 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346

Query: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
             D                 L+            C+  LLQ DA       +    +H A
Sbjct: 347 QGD----------------HLD------------CVRLLLQYDAEIDDITLDHLTPLHVA 378

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           A  GH +  ++LL++       + +G T  PLH+A    H + +E+LL++   +D   E 
Sbjct: 379 AHCGHHRVAKVLLDKGAKPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTES 436

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634
           G T L +A+F GH   V+ L+  GAS  V  NV   TPLH +   GHT   + LL+   N
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQ---N 492

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
              V+ K    QTPL  A   GH + V LLLE  AN +     G T LH     GH E V
Sbjct: 493 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 552

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LLE+E S  C   +G TPLH AA  G    ++ELL    +  +   K+  G TPLH A
Sbjct: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVR-VAELLLERDAHPNAAGKN--GLTPLHVA 609

Query: 755 CYNGNENCIEVLLEQKCF-RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
            ++ N + +++LL +         N +TPLH A   +    A  LL    S+  +    +
Sbjct: 610 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQ 667

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQA 872
           G TPL  AA   H E + LLL   A  N  + SG T L + A+ G     D+L+ +    
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727

Query: 873 DLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           D T +     TPLH+A   G+ K    +L   Q ++ +N K
Sbjct: 728 DATTRMG--YTPLHVASHYGNIKLVKFLL---QHQADVNAK 763



 Score =  288 bits (736), Expect = 2e-77
 Identities = 230/760 (30%), Positives = 334/760 (43%), Gaps = 67/760 (8%)

Query: 38  SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
           +G  +N  +   L  LH A      + V  L+     +    K   T LH+AA     + 
Sbjct: 67  NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEV 126

Query: 98  AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
              ++   ++VN   + G T L+ AA   H+E+V  LL  GAN N   +     L  A  
Sbjct: 127 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 186

Query: 158 MGHLDVVALLINHGAEVTCK-----------------------------DKKGYTPLHAA 188
            GH +VVA LIN+G +   +                              K G+TPLH A
Sbjct: 187 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246

Query: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
           A    +NV + LLN G  ++     G T LHIA   G   +V  L+D GA +     +  
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLH AA + H  +  E+L+++GA +  ++K+G SP+HM A        + L+Q   EID
Sbjct: 307 TPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
            +  D  TPLHVAA  GH  +   L   GA      ++   PLH+A    H      LL 
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
           +G  ID   + G T LH A+  G++  +K L   GA  +  +    TPLH AA   H   
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 485

Query: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
            + L+   A VN      +T LH AA              H N  +L             
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAARI-----------GHTNMVKL------------- 521

Query: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
               LL+N+ANP++    G+  +H AA  GH + +  LLE+  S    +  G T  PLH+
Sbjct: 522 ----LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT--PLHV 575

Query: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
           AA  G  +  E+LL+     +   + G T L +A    + + V+ L+  G S        
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWN 634

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
             TPLH +         R LL+   +  A  V   +G TPL LA   GH + V+LLL K+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV---QGVTPLHLAAQEGHAEMVALLLSKQ 691

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           AN +  +  G T LH     GH     +L++  V +      G TPLH A+  G+   + 
Sbjct: 692 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 751

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            LLQ    + D   K   GY+PLH A   G+ + + +LL+
Sbjct: 752 FLLQ---HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788



 Score =  286 bits (733), Expect = 5e-77
 Identities = 221/730 (30%), Positives = 328/730 (44%), Gaps = 74/730 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 97  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156

Query: 62  EEAVQVLIKHSADVNARDKNWQTP-----------------------------LHVAAAN 92
            E V+ L+++ A+ N   ++  TP                             LH+AA N
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 216

Query: 93  KAVKCAEVII---------------PLL------------------SSVNVSDRGGRTAL 119
              + A V++               PL                   +SVN + + G T L
Sbjct: 217 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 276

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H A+  G+V MV LLL +GA I    K +   LH AA  GH+ +  +L++HGA +  K K
Sbjct: 277 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 336

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G +P+H AA    ++ V+ LL    EID+I +   T LH+A + G   V   L+D GA 
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
            N    NGFTPLH A    H    +ELL+  GA ++  ++ G +PLH+ +  G     + 
Sbjct: 397 PNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q G   +  +    TPLH+AAR GH  +   L  + A           PLH AA   H
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           ++  + LL +    +     G T LH AA  G+VE +  L    A      K G TPLH 
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTIL---GNAHDNSEEL 475
           AA        E L+   A+ N     G T LH A   +++D  K +L   G+ H  +   
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635

Query: 476 ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
                +  K+  +     LLQ   + +    +G   +H AA  GH + + LLL +  +G 
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + SG T  PLHL A  GH    +VL++  V +D     G T L +A+  G+ + V+ L
Sbjct: 696 LGNKSGLT--PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           +   A +  K  +   +PLH +   GHT  + LLL+   +P  V    + G TPL +A  
Sbjct: 754 LQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKR 809

Query: 655 YGHIDAVSLL 664
            G+I    +L
Sbjct: 810 LGYISVTDVL 819



 Score =  262 bits (670), Expect = 9e-70
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 284 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 343

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 344 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 682

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 683 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 732

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792

Query: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 793 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 833



 Score =  201 bits (511), Expect = 3e-51
 Identities = 185/673 (27%), Positives = 287/673 (42%), Gaps = 57/673 (8%)

Query: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
           D  +     A  G   ++   ++NG +I+  +++G   LH+A++ GH  ++  L      
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103

Query: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
                      LH+AAL    +  R+L++ G  ++   + G T L+ AA   ++E +K L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
             +GA+ +   + G TPL  A    H + +  L+  G            ALH AA +D  
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDT 219

Query: 460 RNKTILGNAHDNSEELERA-----RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
           R   +L     N + L +            E     + LL   A+ +   + G   +H A
Sbjct: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 279

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           +  G+   + LLL+R      E+ +    +PLH AA NGH +  E+LL     +  + + 
Sbjct: 280 SRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVT--KRTPLHASVINGHTLCLRLLLEIA 632
           G + + +AA   H +CV  L+   A I   D++T    TPLH +   GH    ++LL+  
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEI---DDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394

Query: 633 DNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
             P +   +   G TPL +A    H+  + LLL+  A++D V   G T LH     GH  
Sbjct: 395 AKPNS---RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451

Query: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
            V+ LL++  S    + +  TPLH AA  GH      LLQ   ++ +   KD+Q  TPLH
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQ--TPLH 508

Query: 753 WACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
            A   G+ N +++LLE             TPLH A    H      LL    S   +C  
Sbjct: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ--ACMT 566

Query: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL----- 866
            KG TPL  AA    V   +LLL   A  NA   +G T L +A  +     V +L     
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626

Query: 867 --------------VNSAQADLTVKDKDLN-------------TPLHLACSKGHEKCALL 899
                         + + Q  + V    L              TPLHLA  +GH +   L
Sbjct: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686

Query: 900 ILDKIQDESLINE 912
           +L K  + +L N+
Sbjct: 687 LLSKQANGNLGNK 699



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 77/290 (26%), Positives = 123/290 (42%), Gaps = 32/290 (11%)

Query: 641 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ 700
           K A   T  + A   G++D     L    +++T +  G   LH     GH + V  LL +
Sbjct: 41  KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100

Query: 701 EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
           E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A    + 
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHL 157

Query: 761 NCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSIVSCRDD 812
             ++ LLE    +     + FTPL  A+   H N  + L+         + +  ++ R+D
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 217

Query: 813 --------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALM 852
                                G TPL  AA  +++   QLLL   A VN    +G T L 
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277

Query: 853 MAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
           +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 278 IASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 326


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  327 bits (837), Expect = 4e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189

Query: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418

Query: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801



 Score =  311 bits (798), Expect = 1e-84
 Identities = 248/780 (31%), Positives = 352/780 (45%), Gaps = 77/780 (9%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N+ ++DG +PL +    G       LI  G +     K     LH+AAR         L 
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
            +  +          PLH+AA   + +  + LL+ G  ++   + G T LH A+  GNV 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
            ++LL   GA    K K   TPLH AA N H    E L+  GA +      G + +H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
             D                 L+            C+  LLQ DA       +    +H A
Sbjct: 314 QGD----------------HLD------------CVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           A  GH +  ++LL++       + +G T  PLH+A    H + +E+LL++   +D   E 
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634
           G T L +A+F GH   V+ L+  GAS  V  NV   TPLH +   GHT   + LL+   N
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQ---N 459

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
              V+ K    QTPL  A   GH + V LLLE  AN +     G T LH     GH E V
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LLE+E S  C   +G TPLH AA  G    ++ELL    +  +   K+  G TPLH A
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVR-VAELLLERDAHPNAAGKN--GLTPLHVA 576

Query: 755 CYNGNENCIEVLLEQKCF-RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
            ++ N + +++LL +         N +TPLH A   +    A  LL    S+  +    +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQ 634

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA--- 870
           G TPL  AA   H E + LLL   A  N  + SG T L + A+ G     D+L+      
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 871 -----------------------------QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
                                        QAD+  K K   +PLH A  +GH     L+L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score =  288 bits (736), Expect = 2e-77
 Identities = 230/760 (30%), Positives = 334/760 (43%), Gaps = 67/760 (8%)

Query: 38  SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
           +G  +N  +   L  LH A      + V  L+     +    K   T LH+AA     + 
Sbjct: 34  NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 98  AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
              ++   ++VN   + G T L+ AA   H+E+V  LL  GAN N   +     L  A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 158 MGHLDVVALLINHGAEVTCK-----------------------------DKKGYTPLHAA 188
            GH +VVA LIN+G +   +                              K G+TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
           A    +NV + LLN G  ++     G T LHIA   G   +V  L+D GA +     +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLH AA + H  +  E+L+++GA +  ++K+G SP+HM A        + L+Q   EID
Sbjct: 274 TPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
            +  D  TPLHVAA  GH  +   L   GA      ++   PLH+A    H      LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
           +G  ID   + G T LH A+  G++  +K L   GA  +  +    TPLH AA   H   
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
            + L+   A VN      +T LH AA              H N  +L             
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARI-----------GHTNMVKL------------- 488

Query: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
               LL+N+ANP++    G+  +H AA  GH + +  LLE+  S    +  G T  PLH+
Sbjct: 489 ----LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT--PLHV 542

Query: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
           AA  G  +  E+LL+     +   + G T L +A    + + V+ L+  G S        
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWN 601

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
             TPLH +         R LL+   +  A  V   +G TPL LA   GH + V+LLL K+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV---QGVTPLHLAAQEGHAEMVALLLSKQ 658

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           AN +  +  G T LH     GH     +L++  V +      G TPLH A+  G+   + 
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            LLQ    + D   K   GY+PLH A   G+ + + +LL+
Sbjct: 719 FLLQ---HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  286 bits (733), Expect = 5e-77
 Identities = 221/730 (30%), Positives = 328/730 (44%), Gaps = 74/730 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 62  EEAVQVLIKHSADVNARDKNWQTP-----------------------------LHVAAAN 92
            E V+ L+++ A+ N   ++  TP                             LH+AA N
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 93  KAVKCAEVII---------------PLL------------------SSVNVSDRGGRTAL 119
              + A V++               PL                   +SVN + + G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H A+  G+V MV LLL +GA I    K +   LH AA  GH+ +  +L++HGA +  K K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G +P+H AA    ++ V+ LL    EID+I +   T LH+A + G   V   L+D GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
            N    NGFTPLH A    H    +ELL+  GA ++  ++ G +PLH+ +  G     + 
Sbjct: 364 PNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q G   +  +    TPLH+AAR GH  +   L  + A           PLH AA   H
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           ++  + LL +    +     G T LH AA  G+VE +  L    A      K G TPLH 
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTIL---GNAHDNSEEL 475
           AA        E L+   A+ N     G T LH A   +++D  K +L   G+ H  +   
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 476 ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
                +  K+  +     LLQ   + +    +G   +H AA  GH + + LLL +  +G 
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + SG T  PLHL A  GH    +VL++  V +D     G T L +A+  G+ + V+ L
Sbjct: 663 LGNKSGLT--PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           +   A +  K  +   +PLH +   GHT  + LLL+   +P  V    + G TPL +A  
Sbjct: 721 LQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKR 776

Query: 655 YGHIDAVSLL 664
            G+I    +L
Sbjct: 777 LGYISVTDVL 786



 Score =  262 bits (670), Expect = 9e-70
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759

Query: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  232 bits (591), Expect = 1e-60
 Identities = 203/687 (29%), Positives = 299/687 (43%), Gaps = 66/687 (9%)

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           G ++N  N NG   LH A+   H  + +ELL +    +   +K G + LH+ A+ G+   
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            + L+  G  ++   + G TPL++AA+  H  ++  L  +GA+          PL +A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H +    L++ G    T  K     LH AA   +     +L  +  +     K G TP
Sbjct: 154 QGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD--------MDRNKTILGNA 468
           LH AA   + +  + L+  GA+VN T   G T LH A+           +DR   I    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
            D    L  A        +   E LL + A    + K G + IH AA   H  C+ LLL+
Sbjct: 270 KDELTPLHCAARNGHVRIS---EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326

Query: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
                 + +    T  PLH+AA+ GHH+  +VLL      + R   G T L +A  K H 
Sbjct: 327 YDAEIDDITLDHLT--PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384

Query: 589 ECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
             +E L+  GASI   D VT+   TPLH +   GH   ++ LL+   +P   +V + K +
Sbjct: 385 RVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVE 438

Query: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
           TPL +A   GH +    LL+ +A V+       T LH     GH   V++LLE   +   
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
             + G TPLH AA  GH   +  LL+   S+  C  K  +G+TPLH A   G     E+L
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTK--KGFTPLHVAAKYGKVRVAELL 555

Query: 767 LEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
           LE+       G N  TPLH A+ +++ +   LLL    S      +  G TPL  AA  +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQN 613

Query: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
            VE  + LL++    NA    G T                                  PL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVT----------------------------------PL 639

Query: 886 HLACSKGHEKCALLILDKIQDESLINE 912
           HLA  +GH +   L+L K  + +L N+
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNK 666



 Score =  181 bits (460), Expect = 2e-45
 Identities = 167/564 (29%), Positives = 248/564 (43%), Gaps = 51/564 (9%)

Query: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
           AA + + D     L +G +I+T ++ G   LH A+  G+V+ +  L           K G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
            T LH AA       +  LV  GANVN     G T L+ AA               +N  
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA--------------QENHL 124

Query: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
           E+              ++FLL+N AN ++  ++G+  +  A   GH   +  L+   N G
Sbjct: 125 EV--------------VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI---NYG 167

Query: 534 FEESDSGATKSP-LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
            +    G  + P LH+AA N   +   VLLQ+  + D+  + G T L +AA   +    +
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 593 ALINPGASI-FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
            L+N GAS+ F   N    TPLH +   G+ + +RLLL   D    ++ K     TPL  
Sbjct: 224 LLLNRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLL---DRGAQIETKTKDELTPLHC 278

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           A   GH+    +LL+  A +      G + +H      H +CV++LL+ +  I       
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
            TPLH AA  GH      LL               G+TPLH AC   +   +E+LL+   
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN---GFTPLHIACKKNHVRVMELLLKTGA 395

Query: 772 FRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
               +     TPLH A    H      LL    S  VS  + K  TPL  AA A H E  
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHTEVA 453

Query: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLAC 889
           + LL++ A VNA     +T L  AA  G    V +L+ N+A  +L       +TPLH+A 
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAA 511

Query: 890 SKGHEKCALLILDKIQDESLINEK 913
            +GH +  L +L+K   ++ + +K
Sbjct: 512 REGHVETVLALLEKEASQACMTKK 535



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
           P +V  ++A   T  + A   G++D     L    +++T +  G   LH     GH + V
Sbjct: 2   PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LL +E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A
Sbjct: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118

Query: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806
               +   ++ LLE    +     + FTPL  A+   H N  + L+         + +  
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
           ++ R+D                     G TPL  AA  +++   QLLL   A VN    +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
           G T L +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  327 bits (837), Expect = 4e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189

Query: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418

Query: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801



 Score =  311 bits (798), Expect = 1e-84
 Identities = 248/780 (31%), Positives = 352/780 (45%), Gaps = 77/780 (9%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N+ ++DG +PL +    G       LI  G +     K     LH+AAR         L 
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
            +  +          PLH+AA   + +  + LL+ G  ++   + G T LH A+  GNV 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
            ++LL   GA    K K   TPLH AA N H    E L+  GA +      G + +H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
             D                 L+            C+  LLQ DA       +    +H A
Sbjct: 314 QGD----------------HLD------------CVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           A  GH +  ++LL++       + +G T  PLH+A    H + +E+LL++   +D   E 
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634
           G T L +A+F GH   V+ L+  GAS  V  NV   TPLH +   GHT   + LL+   N
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQ---N 459

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
              V+ K    QTPL  A   GH + V LLLE  AN +     G T LH     GH E V
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LLE+E S  C   +G TPLH AA  G    ++ELL    +  +   K+  G TPLH A
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVR-VAELLLERDAHPNAAGKN--GLTPLHVA 576

Query: 755 CYNGNENCIEVLLEQKCF-RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
            ++ N + +++LL +         N +TPLH A   +    A  LL    S+  +    +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQ 634

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA--- 870
           G TPL  AA   H E + LLL   A  N  + SG T L + A+ G     D+L+      
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 871 -----------------------------QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
                                        QAD+  K K   +PLH A  +GH     L+L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score =  288 bits (736), Expect = 2e-77
 Identities = 230/760 (30%), Positives = 334/760 (43%), Gaps = 67/760 (8%)

Query: 38  SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
           +G  +N  +   L  LH A      + V  L+     +    K   T LH+AA     + 
Sbjct: 34  NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 98  AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
              ++   ++VN   + G T L+ AA   H+E+V  LL  GAN N   +     L  A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 158 MGHLDVVALLINHGAEVTCK-----------------------------DKKGYTPLHAA 188
            GH +VVA LIN+G +   +                              K G+TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
           A    +NV + LLN G  ++     G T LHIA   G   +V  L+D GA +     +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLH AA + H  +  E+L+++GA +  ++K+G SP+HM A        + L+Q   EID
Sbjct: 274 TPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
            +  D  TPLHVAA  GH  +   L   GA      ++   PLH+A    H      LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
           +G  ID   + G T LH A+  G++  +K L   GA  +  +    TPLH AA   H   
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
            + L+   A VN      +T LH AA              H N  +L             
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARI-----------GHTNMVKL------------- 488

Query: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
               LL+N+ANP++    G+  +H AA  GH + +  LLE+  S    +  G T  PLH+
Sbjct: 489 ----LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT--PLHV 542

Query: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
           AA  G  +  E+LL+     +   + G T L +A    + + V+ L+  G S        
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWN 601

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
             TPLH +         R LL+   +  A  V   +G TPL LA   GH + V+LLL K+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV---QGVTPLHLAAQEGHAEMVALLLSKQ 658

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           AN +  +  G T LH     GH     +L++  V +      G TPLH A+  G+   + 
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            LLQ    + D   K   GY+PLH A   G+ + + +LL+
Sbjct: 719 FLLQ---HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  286 bits (733), Expect = 5e-77
 Identities = 221/730 (30%), Positives = 328/730 (44%), Gaps = 74/730 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 62  EEAVQVLIKHSADVNARDKNWQTP-----------------------------LHVAAAN 92
            E V+ L+++ A+ N   ++  TP                             LH+AA N
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 93  KAVKCAEVII---------------PLL------------------SSVNVSDRGGRTAL 119
              + A V++               PL                   +SVN + + G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H A+  G+V MV LLL +GA I    K +   LH AA  GH+ +  +L++HGA +  K K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G +P+H AA    ++ V+ LL    EID+I +   T LH+A + G   V   L+D GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
            N    NGFTPLH A    H    +ELL+  GA ++  ++ G +PLH+ +  G     + 
Sbjct: 364 PNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q G   +  +    TPLH+AAR GH  +   L  + A           PLH AA   H
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           ++  + LL +    +     G T LH AA  G+VE +  L    A      K G TPLH 
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTIL---GNAHDNSEEL 475
           AA        E L+   A+ N     G T LH A   +++D  K +L   G+ H  +   
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 476 ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
                +  K+  +     LLQ   + +    +G   +H AA  GH + + LLL +  +G 
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + SG T  PLHL A  GH    +VL++  V +D     G T L +A+  G+ + V+ L
Sbjct: 663 LGNKSGLT--PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           +   A +  K  +   +PLH +   GHT  + LLL+   +P  V    + G TPL +A  
Sbjct: 721 LQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKR 776

Query: 655 YGHIDAVSLL 664
            G+I    +L
Sbjct: 777 LGYISVTDVL 786



 Score =  262 bits (670), Expect = 9e-70
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759

Query: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  232 bits (591), Expect = 1e-60
 Identities = 203/687 (29%), Positives = 299/687 (43%), Gaps = 66/687 (9%)

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           G ++N  N NG   LH A+   H  + +ELL +    +   +K G + LH+ A+ G+   
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            + L+  G  ++   + G TPL++AA+  H  ++  L  +GA+          PL +A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H +    L++ G    T  K     LH AA   +     +L  +  +     K G TP
Sbjct: 154 QGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD--------MDRNKTILGNA 468
           LH AA   + +  + L+  GA+VN T   G T LH A+           +DR   I    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
            D    L  A        +   E LL + A    + K G + IH AA   H  C+ LLL+
Sbjct: 270 KDELTPLHCAARNGHVRIS---EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326

Query: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
                 + +    T  PLH+AA+ GHH+  +VLL      + R   G T L +A  K H 
Sbjct: 327 YDAEIDDITLDHLT--PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384

Query: 589 ECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
             +E L+  GASI   D VT+   TPLH +   GH   ++ LL+   +P   +V + K +
Sbjct: 385 RVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVE 438

Query: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
           TPL +A   GH +    LL+ +A V+       T LH     GH   V++LLE   +   
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
             + G TPLH AA  GH   +  LL+   S+  C  K  +G+TPLH A   G     E+L
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTK--KGFTPLHVAAKYGKVRVAELL 555

Query: 767 LEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
           LE+       G N  TPLH A+ +++ +   LLL    S      +  G TPL  AA  +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQN 613

Query: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
            VE  + LL++    NA    G T                                  PL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVT----------------------------------PL 639

Query: 886 HLACSKGHEKCALLILDKIQDESLINE 912
           HLA  +GH +   L+L K  + +L N+
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNK 666



 Score =  181 bits (460), Expect = 2e-45
 Identities = 167/564 (29%), Positives = 248/564 (43%), Gaps = 51/564 (9%)

Query: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
           AA + + D     L +G +I+T ++ G   LH A+  G+V+ +  L           K G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
            T LH AA       +  LV  GANVN     G T L+ AA               +N  
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA--------------QENHL 124

Query: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
           E+              ++FLL+N AN ++  ++G+  +  A   GH   +  L+   N G
Sbjct: 125 EV--------------VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI---NYG 167

Query: 534 FEESDSGATKSP-LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
            +    G  + P LH+AA N   +   VLLQ+  + D+  + G T L +AA   +    +
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 593 ALINPGASI-FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
            L+N GAS+ F   N    TPLH +   G+ + +RLLL   D    ++ K     TPL  
Sbjct: 224 LLLNRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLL---DRGAQIETKTKDELTPLHC 278

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           A   GH+    +LL+  A +      G + +H      H +CV++LL+ +  I       
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
            TPLH AA  GH      LL               G+TPLH AC   +   +E+LL+   
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN---GFTPLHIACKKNHVRVMELLLKTGA 395

Query: 772 FRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
               +     TPLH A    H      LL    S  VS  + K  TPL  AA A H E  
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHTEVA 453

Query: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLAC 889
           + LL++ A VNA     +T L  AA  G    V +L+ N+A  +L       +TPLH+A 
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAA 511

Query: 890 SKGHEKCALLILDKIQDESLINEK 913
            +GH +  L +L+K   ++ + +K
Sbjct: 512 REGHVETVLALLEKEASQACMTKK 535



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
           P +V  ++A   T  + A   G++D     L    +++T +  G   LH     GH + V
Sbjct: 2   PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LL +E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A
Sbjct: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118

Query: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806
               +   ++ LLE    +     + FTPL  A+   H N  + L+         + +  
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
           ++ R+D                     G TPL  AA  +++   QLLL   A VN    +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
           G T L +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  327 bits (837), Expect = 4e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189

Query: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418

Query: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801



 Score =  311 bits (798), Expect = 1e-84
 Identities = 248/780 (31%), Positives = 352/780 (45%), Gaps = 77/780 (9%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N+ ++DG +PL +    G       LI  G +     K     LH+AAR         L 
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
            +  +          PLH+AA   + +  + LL+ G  ++   + G T LH A+  GNV 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
            ++LL   GA    K K   TPLH AA N H    E L+  GA +      G + +H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
             D                 L+            C+  LLQ DA       +    +H A
Sbjct: 314 QGD----------------HLD------------CVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           A  GH +  ++LL++       + +G T  PLH+A    H + +E+LL++   +D   E 
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634
           G T L +A+F GH   V+ L+  GAS  V  NV   TPLH +   GHT   + LL+   N
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQ---N 459

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
              V+ K    QTPL  A   GH + V LLLE  AN +     G T LH     GH E V
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LLE+E S  C   +G TPLH AA  G    ++ELL    +  +   K+  G TPLH A
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVR-VAELLLERDAHPNAAGKN--GLTPLHVA 576

Query: 755 CYNGNENCIEVLLEQKCF-RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
            ++ N + +++LL +         N +TPLH A   +    A  LL    S+  +    +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQ 634

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA--- 870
           G TPL  AA   H E + LLL   A  N  + SG T L + A+ G     D+L+      
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 871 -----------------------------QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
                                        QAD+  K K   +PLH A  +GH     L+L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score =  288 bits (736), Expect = 2e-77
 Identities = 230/760 (30%), Positives = 334/760 (43%), Gaps = 67/760 (8%)

Query: 38  SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
           +G  +N  +   L  LH A      + V  L+     +    K   T LH+AA     + 
Sbjct: 34  NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 98  AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
              ++   ++VN   + G T L+ AA   H+E+V  LL  GAN N   +     L  A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 158 MGHLDVVALLINHGAEVTCK-----------------------------DKKGYTPLHAA 188
            GH +VVA LIN+G +   +                              K G+TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
           A    +NV + LLN G  ++     G T LHIA   G   +V  L+D GA +     +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLH AA + H  +  E+L+++GA +  ++K+G SP+HM A        + L+Q   EID
Sbjct: 274 TPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
            +  D  TPLHVAA  GH  +   L   GA      ++   PLH+A    H      LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
           +G  ID   + G T LH A+  G++  +K L   GA  +  +    TPLH AA   H   
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
            + L+   A VN      +T LH AA              H N  +L             
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARI-----------GHTNMVKL------------- 488

Query: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
               LL+N+ANP++    G+  +H AA  GH + +  LLE+  S    +  G T  PLH+
Sbjct: 489 ----LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT--PLHV 542

Query: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
           AA  G  +  E+LL+     +   + G T L +A    + + V+ L+  G S        
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWN 601

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
             TPLH +         R LL+   +  A  V   +G TPL LA   GH + V+LLL K+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV---QGVTPLHLAAQEGHAEMVALLLSKQ 658

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           AN +  +  G T LH     GH     +L++  V +      G TPLH A+  G+   + 
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            LLQ    + D   K   GY+PLH A   G+ + + +LL+
Sbjct: 719 FLLQ---HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  286 bits (733), Expect = 5e-77
 Identities = 221/730 (30%), Positives = 328/730 (44%), Gaps = 74/730 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 62  EEAVQVLIKHSADVNARDKNWQTP-----------------------------LHVAAAN 92
            E V+ L+++ A+ N   ++  TP                             LH+AA N
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 93  KAVKCAEVII---------------PLL------------------SSVNVSDRGGRTAL 119
              + A V++               PL                   +SVN + + G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H A+  G+V MV LLL +GA I    K +   LH AA  GH+ +  +L++HGA +  K K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G +P+H AA    ++ V+ LL    EID+I +   T LH+A + G   V   L+D GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
            N    NGFTPLH A    H    +ELL+  GA ++  ++ G +PLH+ +  G     + 
Sbjct: 364 PNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q G   +  +    TPLH+AAR GH  +   L  + A           PLH AA   H
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           ++  + LL +    +     G T LH AA  G+VE +  L    A      K G TPLH 
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTIL---GNAHDNSEEL 475
           AA        E L+   A+ N     G T LH A   +++D  K +L   G+ H  +   
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 476 ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
                +  K+  +     LLQ   + +    +G   +H AA  GH + + LLL +  +G 
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + SG T  PLHL A  GH    +VL++  V +D     G T L +A+  G+ + V+ L
Sbjct: 663 LGNKSGLT--PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           +   A +  K  +   +PLH +   GHT  + LLL+   +P  V    + G TPL +A  
Sbjct: 721 LQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKR 776

Query: 655 YGHIDAVSLL 664
            G+I    +L
Sbjct: 777 LGYISVTDVL 786



 Score =  262 bits (670), Expect = 9e-70
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759

Query: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  232 bits (591), Expect = 1e-60
 Identities = 203/687 (29%), Positives = 299/687 (43%), Gaps = 66/687 (9%)

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           G ++N  N NG   LH A+   H  + +ELL +    +   +K G + LH+ A+ G+   
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            + L+  G  ++   + G TPL++AA+  H  ++  L  +GA+          PL +A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H +    L++ G    T  K     LH AA   +     +L  +  +     K G TP
Sbjct: 154 QGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD--------MDRNKTILGNA 468
           LH AA   + +  + L+  GA+VN T   G T LH A+           +DR   I    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
            D    L  A        +   E LL + A    + K G + IH AA   H  C+ LLL+
Sbjct: 270 KDELTPLHCAARNGHVRIS---EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326

Query: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
                 + +    T  PLH+AA+ GHH+  +VLL      + R   G T L +A  K H 
Sbjct: 327 YDAEIDDITLDHLT--PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384

Query: 589 ECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
             +E L+  GASI   D VT+   TPLH +   GH   ++ LL+   +P   +V + K +
Sbjct: 385 RVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVE 438

Query: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
           TPL +A   GH +    LL+ +A V+       T LH     GH   V++LLE   +   
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
             + G TPLH AA  GH   +  LL+   S+  C  K  +G+TPLH A   G     E+L
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTK--KGFTPLHVAAKYGKVRVAELL 555

Query: 767 LEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
           LE+       G N  TPLH A+ +++ +   LLL    S      +  G TPL  AA  +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQN 613

Query: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
            VE  + LL++    NA    G T                                  PL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVT----------------------------------PL 639

Query: 886 HLACSKGHEKCALLILDKIQDESLINE 912
           HLA  +GH +   L+L K  + +L N+
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNK 666



 Score =  181 bits (460), Expect = 2e-45
 Identities = 167/564 (29%), Positives = 248/564 (43%), Gaps = 51/564 (9%)

Query: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
           AA + + D     L +G +I+T ++ G   LH A+  G+V+ +  L           K G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
            T LH AA       +  LV  GANVN     G T L+ AA               +N  
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA--------------QENHL 124

Query: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
           E+              ++FLL+N AN ++  ++G+  +  A   GH   +  L+   N G
Sbjct: 125 EV--------------VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI---NYG 167

Query: 534 FEESDSGATKSP-LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
            +    G  + P LH+AA N   +   VLLQ+  + D+  + G T L +AA   +    +
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 593 ALINPGASI-FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
            L+N GAS+ F   N    TPLH +   G+ + +RLLL   D    ++ K     TPL  
Sbjct: 224 LLLNRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLL---DRGAQIETKTKDELTPLHC 278

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           A   GH+    +LL+  A +      G + +H      H +CV++LL+ +  I       
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
            TPLH AA  GH      LL               G+TPLH AC   +   +E+LL+   
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN---GFTPLHIACKKNHVRVMELLLKTGA 395

Query: 772 FRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
               +     TPLH A    H      LL    S  VS  + K  TPL  AA A H E  
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHTEVA 453

Query: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLAC 889
           + LL++ A VNA     +T L  AA  G    V +L+ N+A  +L       +TPLH+A 
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAA 511

Query: 890 SKGHEKCALLILDKIQDESLINEK 913
            +GH +  L +L+K   ++ + +K
Sbjct: 512 REGHVETVLALLEKEASQACMTKK 535



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
           P +V  ++A   T  + A   G++D     L    +++T +  G   LH     GH + V
Sbjct: 2   PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LL +E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A
Sbjct: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118

Query: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806
               +   ++ LLE    +     + FTPL  A+   H N  + L+         + +  
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
           ++ R+D                     G TPL  AA  +++   QLLL   A VN    +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
           G T L +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  327 bits (837), Expect = 4e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189

Query: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418

Query: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801



 Score =  311 bits (798), Expect = 1e-84
 Identities = 248/780 (31%), Positives = 352/780 (45%), Gaps = 77/780 (9%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N+ ++DG +PL +    G       LI  G +     K     LH+AAR         L 
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193

Query: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
            +  +          PLH+AA   + +  + LL+ G  ++   + G T LH A+  GNV 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
            ++LL   GA    K K   TPLH AA N H    E L+  GA +      G + +H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
             D                 L+            C+  LLQ DA       +    +H A
Sbjct: 314 QGD----------------HLD------------CVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           A  GH +  ++LL++       + +G T  PLH+A    H + +E+LL++   +D   E 
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634
           G T L +A+F GH   V+ L+  GAS  V  NV   TPLH +   GHT   + LL+   N
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQ---N 459

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
              V+ K    QTPL  A   GH + V LLLE  AN +     G T LH     GH E V
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LLE+E S  C   +G TPLH AA  G    ++ELL    +  +   K+  G TPLH A
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVR-VAELLLERDAHPNAAGKN--GLTPLHVA 576

Query: 755 CYNGNENCIEVLLEQKCF-RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
            ++ N + +++LL +         N +TPLH A   +    A  LL    S+  +    +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQ 634

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA--- 870
           G TPL  AA   H E + LLL   A  N  + SG T L + A+ G     D+L+      
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 871 -----------------------------QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
                                        QAD+  K K   +PLH A  +GH     L+L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754



 Score =  288 bits (736), Expect = 2e-77
 Identities = 230/760 (30%), Positives = 334/760 (43%), Gaps = 67/760 (8%)

Query: 38  SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
           +G  +N  +   L  LH A      + V  L+     +    K   T LH+AA     + 
Sbjct: 34  NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 98  AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
              ++   ++VN   + G T L+ AA   H+E+V  LL  GAN N   +     L  A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 158 MGHLDVVALLINHGAEVTCK-----------------------------DKKGYTPLHAA 188
            GH +VVA LIN+G +   +                              K G+TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
           A    +NV + LLN G  ++     G T LHIA   G   +V  L+D GA +     +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLH AA + H  +  E+L+++GA +  ++K+G SP+HM A        + L+Q   EID
Sbjct: 274 TPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
            +  D  TPLHVAA  GH  +   L   GA      ++   PLH+A    H      LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
           +G  ID   + G T LH A+  G++  +K L   GA  +  +    TPLH AA   H   
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
            + L+   A VN      +T LH AA              H N  +L             
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARI-----------GHTNMVKL------------- 488

Query: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
               LL+N+ANP++    G+  +H AA  GH + +  LLE+  S    +  G T  PLH+
Sbjct: 489 ----LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT--PLHV 542

Query: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
           AA  G  +  E+LL+     +   + G T L +A    + + V+ L+  G S        
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWN 601

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
             TPLH +         R LL+   +  A  V   +G TPL LA   GH + V+LLL K+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV---QGVTPLHLAAQEGHAEMVALLLSKQ 658

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           AN +  +  G T LH     GH     +L++  V +      G TPLH A+  G+   + 
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
            LLQ    + D   K   GY+PLH A   G+ + + +LL+
Sbjct: 719 FLLQ---HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  286 bits (733), Expect = 5e-77
 Identities = 221/730 (30%), Positives = 328/730 (44%), Gaps = 74/730 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 62  EEAVQVLIKHSADVNARDKNWQTP-----------------------------LHVAAAN 92
            E V+ L+++ A+ N   ++  TP                             LH+AA N
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 93  KAVKCAEVII---------------PLL------------------SSVNVSDRGGRTAL 119
              + A V++               PL                   +SVN + + G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H A+  G+V MV LLL +GA I    K +   LH AA  GH+ +  +L++HGA +  K K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G +P+H AA    ++ V+ LL    EID+I +   T LH+A + G   V   L+D GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
            N    NGFTPLH A    H    +ELL+  GA ++  ++ G +PLH+ +  G     + 
Sbjct: 364 PNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q G   +  +    TPLH+AAR GH  +   L  + A           PLH AA   H
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           ++  + LL +    +     G T LH AA  G+VE +  L    A      K G TPLH 
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTIL---GNAHDNSEEL 475
           AA        E L+   A+ N     G T LH A   +++D  K +L   G+ H  +   
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 476 ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
                +  K+  +     LLQ   + +    +G   +H AA  GH + + LLL +  +G 
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + SG T  PLHL A  GH    +VL++  V +D     G T L +A+  G+ + V+ L
Sbjct: 663 LGNKSGLT--PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           +   A +  K  +   +PLH +   GHT  + LLL+   +P  V    + G TPL +A  
Sbjct: 721 LQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKR 776

Query: 655 YGHIDAVSLL 664
            G+I    +L
Sbjct: 777 LGYISVTDVL 786



 Score =  262 bits (670), Expect = 9e-70
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759

Query: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  232 bits (591), Expect = 1e-60
 Identities = 203/687 (29%), Positives = 299/687 (43%), Gaps = 66/687 (9%)

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           G ++N  N NG   LH A+   H  + +ELL +    +   +K G + LH+ A+ G+   
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            + L+  G  ++   + G TPL++AA+  H  ++  L  +GA+          PL +A  
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H +    L++ G    T  K     LH AA   +     +L  +  +     K G TP
Sbjct: 154 QGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD--------MDRNKTILGNA 468
           LH AA   + +  + L+  GA+VN T   G T LH A+           +DR   I    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
            D    L  A        +   E LL + A    + K G + IH AA   H  C+ LLL+
Sbjct: 270 KDELTPLHCAARNGHVRIS---EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326

Query: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
                 + +    T  PLH+AA+ GHH+  +VLL      + R   G T L +A  K H 
Sbjct: 327 YDAEIDDITLDHLT--PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384

Query: 589 ECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
             +E L+  GASI   D VT+   TPLH +   GH   ++ LL+   +P   +V + K +
Sbjct: 385 RVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVE 438

Query: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
           TPL +A   GH +    LL+ +A V+       T LH     GH   V++LLE   +   
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
             + G TPLH AA  GH   +  LL+   S+  C  K  +G+TPLH A   G     E+L
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTK--KGFTPLHVAAKYGKVRVAELL 555

Query: 767 LEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
           LE+       G N  TPLH A+ +++ +   LLL    S      +  G TPL  AA  +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQN 613

Query: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
            VE  + LL++    NA    G T                                  PL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVT----------------------------------PL 639

Query: 886 HLACSKGHEKCALLILDKIQDESLINE 912
           HLA  +GH +   L+L K  + +L N+
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNK 666



 Score =  181 bits (460), Expect = 2e-45
 Identities = 167/564 (29%), Positives = 248/564 (43%), Gaps = 51/564 (9%)

Query: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
           AA + + D     L +G +I+T ++ G   LH A+  G+V+ +  L           K G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
            T LH AA       +  LV  GANVN     G T L+ AA               +N  
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA--------------QENHL 124

Query: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
           E+              ++FLL+N AN ++  ++G+  +  A   GH   +  L+   N G
Sbjct: 125 EV--------------VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI---NYG 167

Query: 534 FEESDSGATKSP-LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
            +    G  + P LH+AA N   +   VLLQ+  + D+  + G T L +AA   +    +
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 593 ALINPGASI-FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
            L+N GAS+ F   N    TPLH +   G+ + +RLLL   D    ++ K     TPL  
Sbjct: 224 LLLNRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLL---DRGAQIETKTKDELTPLHC 278

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           A   GH+    +LL+  A +      G + +H      H +CV++LL+ +  I       
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
            TPLH AA  GH      LL               G+TPLH AC   +   +E+LL+   
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN---GFTPLHIACKKNHVRVMELLLKTGA 395

Query: 772 FRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
               +     TPLH A    H      LL    S  VS  + K  TPL  AA A H E  
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHTEVA 453

Query: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLAC 889
           + LL++ A VNA     +T L  AA  G    V +L+ N+A  +L       +TPLH+A 
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAA 511

Query: 890 SKGHEKCALLILDKIQDESLINEK 913
            +GH +  L +L+K   ++ + +K
Sbjct: 512 REGHVETVLALLEKEASQACMTKK 535



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)

Query: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
           P +V  ++A   T  + A   G++D     L    +++T +  G   LH     GH + V
Sbjct: 2   PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
             LL +E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A
Sbjct: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118

Query: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806
               +   ++ LLE    +     + FTPL  A+   H N  + L+         + +  
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178

Query: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
           ++ R+D                     G TPL  AA  +++   QLLL   A VN    +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
           G T L +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  305 bits (782), Expect = 1e-82
 Identities = 254/850 (29%), Positives = 376/850 (44%), Gaps = 70/850 (8%)

Query: 55  RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114
           RA  + + + V   +K   D+N  ++N    LH+AA    V   + ++   SSV+ + + 
Sbjct: 16  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75

Query: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
           G TALH A+L G  E+V +L+ +GANINA  +     L+ AA   H+DVV  L+ +GA  
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
           +   + G+TPL  A   G    V  LL    E D        ALHIA           L+
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 191

Query: 235 --DYGAN------VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
             D+ A+      VN+   +GFTPLH AA   +  +   LL+N GA V+  +++G +PLH
Sbjct: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 250

Query: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346
           + +  G     + L+  GG+ID   +DG TPLH AAR GH+ ++  L   GA       +
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406
            + PLH+AA   H +C + LL     +D       T LH AA  G+    KLL    A+ 
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370

Query: 407 HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466
           + +   G TPLH A        +E LV  GA++    + G T +H AA          +G
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA---------FMG 421

Query: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
           + +                    +  LLQN A+P + +  G  ++H AA  G  + +  L
Sbjct: 422 HLN-------------------IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462

Query: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
           L   N    ++ +   ++PLH+A+  G  + +++LLQ +   D     G T L ++A +G
Sbjct: 463 LR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520

Query: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
             +    L+  GA+       TK+  TPLH +   G     +LLL+      A D     
Sbjct: 521 QVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKN 574

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
           G TPL +A  Y +     LLLEK A+       G T LH        +    LL      
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634

Query: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
                +G TPLH A+  GH   ++ LL    +          G T LH A      N  +
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVAD 691

Query: 765 VL----LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
           +L     +Q    K     +TPL  A    +GN   +       + V+ +   G TPL  
Sbjct: 692 ILTKHGADQDAHTKL---GYTPLIVAC--HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 746

Query: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL------VNSAQADL 874
           AA   H   + +LL+H A  NA   +G TAL +A   G    VD L      V +    +
Sbjct: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTI 806

Query: 875 TVKDKDLNTP 884
           T K K LN P
Sbjct: 807 TEKHK-LNVP 815



 Score =  294 bits (752), Expect = 3e-79
 Identities = 234/777 (30%), Positives = 344/777 (44%), Gaps = 79/777 (10%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD V   +  G ++   ++ G   LH AA  G + +V+ LL  G  +D     G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQ  VV  L+  GAN+N  + NGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLENGANQ 135

Query: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305
           +  ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195

Query: 306 EIDCVDK--------DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357
             D   K         G TPLH+AA YG+  +   L   GA       + + PLH+A+  
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255

Query: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
            +++  + LL  G +ID   + G T LH AA  G+ + ++LL   GA    + K G +PL
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315

Query: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
           H AA   H  C++ L+   A V++      TALH AA     R                 
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR----------------- 358

Query: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
                        + LL   ANP+ R   G+  +H A      + +ELL++   S    +
Sbjct: 359 -----------VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407

Query: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
           +SG T  P+H+AA+ GH   + +LLQ+    D+ + +G TAL +AA  G  E V  L+  
Sbjct: 408 ESGLT--PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 598 GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657
           GA +  +    ++TPLH +   G T  ++LLL+   +P+A       G TPL ++   G 
Sbjct: 466 GALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAA---TTNGYTPLHISAREGQ 521

Query: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
           +D  S+LLE  A        G T LH     G  +  ++LL++  +       G TPLH 
Sbjct: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581

Query: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777
           AA   +      LL+   S          GYTPLH A           LL        + 
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 638

Query: 778 NP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
               TPLH A    H +  +LLL     + +      G T L  AA  D V    +L +H
Sbjct: 639 KQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696

Query: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
            A  +A    G T L++A   G    V+ L+    A++  K K+  TPLH A  +GH
Sbjct: 697 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGH 752



 Score =  282 bits (722), Expect = 9e-76
 Identities = 229/744 (30%), Positives = 345/744 (46%), Gaps = 36/744 (4%)

Query: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
           D+NT +      LH+AA  G   +++ L+  G+ V++      T LH A  +   E V+V
Sbjct: 35  DINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKV 94

Query: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
           L+K  A++NA+ +N  TPL++AA    +   + ++   ++ + +   G T L  A   GH
Sbjct: 95  LVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 154

Query: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI--NHGAEVTCK------DK 179
            + V +LL          K    ALH AA        ALL+  +H A+V  K       +
Sbjct: 155 NQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G+TPLH AA  G +NV   LLN G  +D     G T LH+A   G   +V  L+D G  
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
           ++    +G TPLH AA S H  + +ELL+  GA +  ++K+G SPLHM A        + 
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q+   +D V  D  T LHVAA  GH  +   L    A+     ++   PLH+A     
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
                 L+  G  I    + G T +H AA  G++  + LL  +GA     +  G T LH 
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELE- 476
           AA       +  L+  GA V+      +T LH A+         +L    AH ++     
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509

Query: 477 ------RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                  ARE +   A++    LL+  A  S+  K+G+  +H AA YG     +LLL+R 
Sbjct: 510 YTPLHISAREGQVDVASV----LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
            +      +G T  PLH+AA+  + +   +LL+         + G T L +AA K   + 
Sbjct: 566 AAADSAGKNGLT--PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
              L+N GA   +   VTK+  TPLH +   GHT  + LLL+   N   + +    G T 
Sbjct: 624 ASTLLNYGAETNI---VTKQGVTPLHLASQEGHTDMVTLLLDKGAN---IHMSTKSGLTS 677

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L LA     ++   +L +  A+ D    LG T L      G+ + V  LL+Q  ++  K 
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 737

Query: 709 SRGRTPLHYAAARGHATWLSELLQ 732
             G TPLH AA +GH   ++ LLQ
Sbjct: 738 KNGYTPLHQAAQQGHTHIINVLLQ 761



 Score =  268 bits (685), Expect = 2e-71
 Identities = 209/706 (29%), Positives = 315/706 (44%), Gaps = 49/706 (6%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +  ++N       TPL++AA     ++++ L+ +GA  +       TPL  A+   
Sbjct: 94  VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153

Query: 61  SEEAVQVLIK-------------------------------HSAD------VNARDKNWQ 83
             +AV +L++                               H+AD      VN   ++  
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213

Query: 84  TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
           TPLH+AA    V  A +++   ++V+ + R G T LH A+  G+  MV LLL +G  I+A
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
             +     LH AA  GH  VV LL+  GA +  + K G +PLH AA    +  VKHLL  
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333

Query: 204 GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
              +D++ +   TALH+A + G   V   L+D  AN N    NGFTPLH A         
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-IKV 392

Query: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
           +ELLV  GA +   ++ G +P+H+ A  G       L+QNG   D  +  G T LH+AAR
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452

Query: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
            G   ++  L  +GA           PLH+A+    ++  + LL      D     G T 
Sbjct: 453 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 512

Query: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
           LH +A  G V+   +L  +GA      K G TPLH AA        + L+   A  +   
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 572

Query: 444 DWGRTALHYAAASDMDRNKTIL----GNAHDNSEELERARELKEKEATLCL-EFLLQNDA 498
             G T LH AA  D  +   +L     + H  ++       +  K+  + +   LL   A
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632

Query: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558
             +I  K+G   +H A+  GH   + LLL++  +    + SG T   LHLAA        
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS--LHLAAQEDKVNVA 690

Query: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI 618
           ++L +   D D   + G T L +A   G+ + V  L+  GA++  K      TPLH +  
Sbjct: 691 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQ 749

Query: 619 NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
            GHT  + +LL+    P A     A G T L +A   G+I  V  L
Sbjct: 750 QGHTHIINVLLQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 792



 Score =  226 bits (575), Expect = 1e-58
 Identities = 200/669 (29%), Positives = 279/669 (41%), Gaps = 92/669 (13%)

Query: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
           D N     AAR G+   +      G D   C  + +  LHLAA   H    ++LL  G  
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
           +D+  K G T LH A+  G  E +K+L   GA+ + + + G TPL+ AA   H   ++ L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTI---LGNAHDNSEELERARELKEKEATLC 489
           +  GAN +   + G T L  A A     N+ +   L N       L        K+ T  
Sbjct: 129 LENGANQSTATEDGFTPL--AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 186

Query: 490 LEFLLQNDANPSIRDK--------EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
              LLQND N  ++ K         G+  +H AA YG+     LLL R  +    + +G 
Sbjct: 187 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 246

Query: 542 TK-------------------------------SPLHLAAYNGHHQALEVLLQSLVDLDI 570
           T                                +PLH AA +GH Q +E+LL+    L  
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306

Query: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLL 628
           R + G + L +AA   H ECV+ L+   A +   D+VT    T LH +   GH    +LL
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPV---DDVTLDYLTALHVAAHCGHYRVTKLL 363

Query: 629 LEIADNPEA------------------------------VDVKDAKGQTPLMLAVAYGHI 658
           L+   NP A                              +      G TP+ +A   GH+
Sbjct: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 423

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
           + V LLL+  A+ D  +I G TALH     G  E V+ LL     +  +    +TPLH A
Sbjct: 424 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 483

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
           +  G  T + +LL   ++  D       GYTPLH +   G  +   VLLE          
Sbjct: 484 SRLGK-TEIVQLLLQHMAHPDAA--TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540

Query: 779 P-FTPLHCAIINDHGNCASLLL---GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLL 834
             FTPLH A      + A LLL    A DS+        G TPL  AA  D+ +   LLL
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-----GKNGLTPLHVAAHYDNQKVALLLL 595

Query: 835 RHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHE 894
              A  +A   +G T L +AA+  Q      L+N   A+  +  K   TPLHLA  +GH 
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHT 654

Query: 895 KCALLILDK 903
               L+LDK
Sbjct: 655 DMVTLLLDK 663



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 58/174 (33%), Positives = 84/174 (48%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L++   + N +  +  TPLH+A+  G  +++ LL+  GA ++      LT LH A     
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 686

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
                +L KH AD +A  K   TPL VA     VK    ++   ++VN   + G T LH 
Sbjct: 687 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 746

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
           AA  GH  ++N+LL  GA  NA       AL  A  +G++ VV  L     EVT
Sbjct: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  305 bits (782), Expect = 1e-82
 Identities = 254/850 (29%), Positives = 376/850 (44%), Gaps = 70/850 (8%)

Query: 55  RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114
           RA  + + + V   +K   D+N  ++N    LH+AA    V   + ++   SSV+ + + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
           G TALH A+L G  E+V +L+ +GANINA  +     L+ AA   H+DVV  L+ +GA  
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
           +   + G+TPL  A   G    V  LL    E D        ALHIA           L+
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 235 --DYGAN------VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
             D+ A+      VN+   +GFTPLH AA   +  +   LL+N GA V+  +++G +PLH
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271

Query: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346
           + +  G     + L+  GG+ID   +DG TPLH AAR GH+ ++  L   GA       +
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406
            + PLH+AA   H +C + LL     +D       T LH AA  G+    KLL    A+ 
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 407 HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466
           + +   G TPLH A        +E LV  GA++    + G T +H AA          +G
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA---------FMG 442

Query: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
           + +                    +  LLQN A+P + +  G  ++H AA  G  + +  L
Sbjct: 443 HLN-------------------IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
           L   N    ++ +   ++PLH+A+  G  + +++LLQ +   D     G T L ++A +G
Sbjct: 484 LR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
             +    L+  GA+       TK+  TPLH +   G     +LLL+      A D     
Sbjct: 542 QVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKN 595

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
           G TPL +A  Y +     LLLEK A+       G T LH        +    LL      
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
                +G TPLH A+  GH   ++ LL    +          G T LH A      N  +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVAD 712

Query: 765 VL----LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
           +L     +Q    K     +TPL  A    +GN   +       + V+ +   G TPL  
Sbjct: 713 ILTKHGADQDAHTKL---GYTPLIVAC--HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767

Query: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL------VNSAQADL 874
           AA   H   + +LL+H A  NA   +G TAL +A   G    VD L      V +    +
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTI 827

Query: 875 TVKDKDLNTP 884
           T K K LN P
Sbjct: 828 TEKHK-LNVP 836



 Score =  294 bits (752), Expect = 3e-79
 Identities = 234/777 (30%), Positives = 344/777 (44%), Gaps = 79/777 (10%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD V   +  G ++   ++ G   LH AA  G + +V+ LL  G  +D     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQ  VV  L+  GAN+N  + NGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLENGANQ 156

Query: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305
           +  ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216

Query: 306 EIDCVDK--------DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357
             D   K         G TPLH+AA YG+  +   L   GA       + + PLH+A+  
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276

Query: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
            +++  + LL  G +ID   + G T LH AA  G+ + ++LL   GA    + K G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336

Query: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
           H AA   H  C++ L+   A V++      TALH AA     R                 
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR----------------- 379

Query: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
                        + LL   ANP+ R   G+  +H A      + +ELL++   S    +
Sbjct: 380 -----------VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428

Query: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
           +SG T  P+H+AA+ GH   + +LLQ+    D+ + +G TAL +AA  G  E V  L+  
Sbjct: 429 ESGLT--PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 598 GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657
           GA +  +    ++TPLH +   G T  ++LLL+   +P+A       G TPL ++   G 
Sbjct: 487 GALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAA---TTNGYTPLHISAREGQ 542

Query: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
           +D  S+LLE  A        G T LH     G  +  ++LL++  +       G TPLH 
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602

Query: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777
           AA   +      LL+   S          GYTPLH A           LL        + 
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659

Query: 778 NP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
               TPLH A    H +  +LLL     + +      G T L  AA  D V    +L +H
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
            A  +A    G T L++A   G    V+ L+    A++  K K+  TPLH A  +GH
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGH 773



 Score =  282 bits (722), Expect = 9e-76
 Identities = 229/744 (30%), Positives = 345/744 (46%), Gaps = 36/744 (4%)

Query: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
           D+NT +      LH+AA  G   +++ L+  G+ V++      T LH A  +   E V+V
Sbjct: 56  DINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKV 115

Query: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
           L+K  A++NA+ +N  TPL++AA    +   + ++   ++ + +   G T L  A   GH
Sbjct: 116 LVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI--NHGAEVTCK------DK 179
            + V +LL          K    ALH AA        ALL+  +H A+V  K       +
Sbjct: 176 NQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G+TPLH AA  G +NV   LLN G  +D     G T LH+A   G   +V  L+D G  
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
           ++    +G TPLH AA S H  + +ELL+  GA +  ++K+G SPLHM A        + 
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q+   +D V  D  T LHVAA  GH  +   L    A+     ++   PLH+A     
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
                 L+  G  I    + G T +H AA  G++  + LL  +GA     +  G T LH 
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELE- 476
           AA       +  L+  GA V+      +T LH A+         +L    AH ++     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 477 ------RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                  ARE +   A++    LL+  A  S+  K+G+  +H AA YG     +LLL+R 
Sbjct: 531 YTPLHISAREGQVDVASV----LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
            +      +G T  PLH+AA+  + +   +LL+         + G T L +AA K   + 
Sbjct: 587 AAADSAGKNGLT--PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
              L+N GA   +   VTK+  TPLH +   GHT  + LLL+   N   + +    G T 
Sbjct: 645 ASTLLNYGAETNI---VTKQGVTPLHLASQEGHTDMVTLLLDKGAN---IHMSTKSGLTS 698

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L LA     ++   +L +  A+ D    LG T L      G+ + V  LL+Q  ++  K 
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758

Query: 709 SRGRTPLHYAAARGHATWLSELLQ 732
             G TPLH AA +GH   ++ LLQ
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  268 bits (685), Expect = 2e-71
 Identities = 209/706 (29%), Positives = 315/706 (44%), Gaps = 49/706 (6%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +  ++N       TPL++AA     ++++ L+ +GA  +       TPL  A+   
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174

Query: 61  SEEAVQVLIK-------------------------------HSAD------VNARDKNWQ 83
             +AV +L++                               H+AD      VN   ++  
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 84  TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
           TPLH+AA    V  A +++   ++V+ + R G T LH A+  G+  MV LLL +G  I+A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
             +     LH AA  GH  VV LL+  GA +  + K G +PLH AA    +  VKHLL  
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 204 GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
              +D++ +   TALH+A + G   V   L+D  AN N    NGFTPLH A         
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-IKV 413

Query: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
           +ELLV  GA +   ++ G +P+H+ A  G       L+QNG   D  +  G T LH+AAR
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
            G   ++  L  +GA           PLH+A+    ++  + LL      D     G T 
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 533

Query: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
           LH +A  G V+   +L  +GA      K G TPLH AA        + L+   A  +   
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593

Query: 444 DWGRTALHYAAASDMDRNKTIL----GNAHDNSEELERARELKEKEATLCL-EFLLQNDA 498
             G T LH AA  D  +   +L     + H  ++       +  K+  + +   LL   A
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558
             +I  K+G   +H A+  GH   + LLL++  +    + SG T   LHLAA        
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS--LHLAAQEDKVNVA 711

Query: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI 618
           ++L +   D D   + G T L +A   G+ + V  L+  GA++  K      TPLH +  
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQ 770

Query: 619 NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
            GHT  + +LL+    P A     A G T L +A   G+I  V  L
Sbjct: 771 QGHTHIINVLLQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 813



 Score =  226 bits (575), Expect = 1e-58
 Identities = 200/669 (29%), Positives = 279/669 (41%), Gaps = 92/669 (13%)

Query: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
           D N     AAR G+   +      G D   C  + +  LHLAA   H    ++LL  G  
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
           +D+  K G T LH A+  G  E +K+L   GA+ + + + G TPL+ AA   H   ++ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTI---LGNAHDNSEELERARELKEKEATLC 489
           +  GAN +   + G T L  A A     N+ +   L N       L        K+ T  
Sbjct: 150 LENGANQSTATEDGFTPL--AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 207

Query: 490 LEFLLQNDANPSIRDK--------EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
              LLQND N  ++ K         G+  +H AA YG+     LLL R  +    + +G 
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 542 TK-------------------------------SPLHLAAYNGHHQALEVLLQSLVDLDI 570
           T                                +PLH AA +GH Q +E+LL+    L  
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLL 628
           R + G + L +AA   H ECV+ L+   A +   D+VT    T LH +   GH    +LL
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPV---DDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 629 LEIADNPEA------------------------------VDVKDAKGQTPLMLAVAYGHI 658
           L+   NP A                              +      G TP+ +A   GH+
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
           + V LLL+  A+ D  +I G TALH     G  E V+ LL     +  +    +TPLH A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
           +  G  T + +LL   ++  D       GYTPLH +   G  +   VLLE          
Sbjct: 505 SRLGK-TEIVQLLLQHMAHPDAA--TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561

Query: 779 P-FTPLHCAIINDHGNCASLLL---GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLL 834
             FTPLH A      + A LLL    A DS+        G TPL  AA  D+ +   LLL
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-----GKNGLTPLHVAAHYDNQKVALLLL 616

Query: 835 RHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHE 894
              A  +A   +G T L +AA+  Q      L+N   A+  +  K   TPLHLA  +GH 
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHT 675

Query: 895 KCALLILDK 903
               L+LDK
Sbjct: 676 DMVTLLLDK 684



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 58/174 (33%), Positives = 84/174 (48%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L++   + N +  +  TPLH+A+  G  +++ LL+  GA ++      LT LH A     
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
                +L KH AD +A  K   TPL VA     VK    ++   ++VN   + G T LH 
Sbjct: 708 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
           AA  GH  ++N+LL  GA  NA       AL  A  +G++ VV  L     EVT
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  305 bits (782), Expect = 1e-82
 Identities = 254/850 (29%), Positives = 376/850 (44%), Gaps = 70/850 (8%)

Query: 55  RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114
           RA  + + + V   +K   D+N  ++N    LH+AA    V   + ++   SSV+ + + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
           G TALH A+L G  E+V +L+ +GANINA  +     L+ AA   H+DVV  L+ +GA  
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
           +   + G+TPL  A   G    V  LL    E D        ALHIA           L+
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212

Query: 235 --DYGAN------VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
             D+ A+      VN+   +GFTPLH AA   +  +   LL+N GA V+  +++G +PLH
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271

Query: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346
           + +  G     + L+  GG+ID   +DG TPLH AAR GH+ ++  L   GA       +
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406
            + PLH+AA   H +C + LL     +D       T LH AA  G+    KLL    A+ 
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 407 HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466
           + +   G TPLH A        +E LV  GA++    + G T +H AA          +G
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA---------FMG 442

Query: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
           + +                    +  LLQN A+P + +  G  ++H AA  G  + +  L
Sbjct: 443 HLN-------------------IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
           L   N    ++ +   ++PLH+A+  G  + +++LLQ +   D     G T L ++A +G
Sbjct: 484 LR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
             +    L+  GA+       TK+  TPLH +   G     +LLL+      A D     
Sbjct: 542 QVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKN 595

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
           G TPL +A  Y +     LLLEK A+       G T LH        +    LL      
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
                +G TPLH A+  GH   ++ LL    +          G T LH A      N  +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVAD 712

Query: 765 VL----LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
           +L     +Q    K     +TPL  A    +GN   +       + V+ +   G TPL  
Sbjct: 713 ILTKHGADQDAHTKL---GYTPLIVAC--HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767

Query: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL------VNSAQADL 874
           AA   H   + +LL+H A  NA   +G TAL +A   G    VD L      V +    +
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTI 827

Query: 875 TVKDKDLNTP 884
           T K K LN P
Sbjct: 828 TEKHK-LNVP 836



 Score =  294 bits (752), Expect = 3e-79
 Identities = 234/777 (30%), Positives = 344/777 (44%), Gaps = 79/777 (10%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  G+LD V   +  G ++   ++ G   LH AA  G + +V+ LL  G  +D     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQ  VV  L+  GAN+N  + NGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLENGANQ 156

Query: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305
           +  ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216

Query: 306 EIDCVDK--------DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357
             D   K         G TPLH+AA YG+  +   L   GA       + + PLH+A+  
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276

Query: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
            +++  + LL  G +ID   + G T LH AA  G+ + ++LL   GA    + K G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336

Query: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
           H AA   H  C++ L+   A V++      TALH AA     R                 
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR----------------- 379

Query: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
                        + LL   ANP+ R   G+  +H A      + +ELL++   S    +
Sbjct: 380 -----------VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428

Query: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
           +SG T  P+H+AA+ GH   + +LLQ+    D+ + +G TAL +AA  G  E V  L+  
Sbjct: 429 ESGLT--PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 598 GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657
           GA +  +    ++TPLH +   G T  ++LLL+   +P+A       G TPL ++   G 
Sbjct: 487 GALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAA---TTNGYTPLHISAREGQ 542

Query: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
           +D  S+LLE  A        G T LH     G  +  ++LL++  +       G TPLH 
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602

Query: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777
           AA   +      LL+   S          GYTPLH A           LL        + 
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659

Query: 778 NP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
               TPLH A    H +  +LLL     + +      G T L  AA  D V    +L +H
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
            A  +A    G T L++A   G    V+ L+    A++  K K+  TPLH A  +GH
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGH 773



 Score =  282 bits (722), Expect = 9e-76
 Identities = 229/744 (30%), Positives = 345/744 (46%), Gaps = 36/744 (4%)

Query: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
           D+NT +      LH+AA  G   +++ L+  G+ V++      T LH A  +   E V+V
Sbjct: 56  DINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKV 115

Query: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
           L+K  A++NA+ +N  TPL++AA    +   + ++   ++ + +   G T L  A   GH
Sbjct: 116 LVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI--NHGAEVTCK------DK 179
            + V +LL          K    ALH AA        ALL+  +H A+V  K       +
Sbjct: 176 NQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G+TPLH AA  G +NV   LLN G  +D     G T LH+A   G   +V  L+D G  
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
           ++    +G TPLH AA S H  + +ELL+  GA +  ++K+G SPLHM A        + 
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
           L+Q+   +D V  D  T LHVAA  GH  +   L    A+     ++   PLH+A     
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
                 L+  G  I    + G T +H AA  G++  + LL  +GA     +  G T LH 
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELE- 476
           AA       +  L+  GA V+      +T LH A+         +L    AH ++     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 477 ------RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
                  ARE +   A++    LL+  A  S+  K+G+  +H AA YG     +LLL+R 
Sbjct: 531 YTPLHISAREGQVDVASV----LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586

Query: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
            +      +G T  PLH+AA+  + +   +LL+         + G T L +AA K   + 
Sbjct: 587 AAADSAGKNGLT--PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
              L+N GA   +   VTK+  TPLH +   GHT  + LLL+   N   + +    G T 
Sbjct: 645 ASTLLNYGAETNI---VTKQGVTPLHLASQEGHTDMVTLLLDKGAN---IHMSTKSGLTS 698

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L LA     ++   +L +  A+ D    LG T L      G+ + V  LL+Q  ++  K 
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758

Query: 709 SRGRTPLHYAAARGHATWLSELLQ 732
             G TPLH AA +GH   ++ LLQ
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  268 bits (685), Expect = 2e-71
 Identities = 209/706 (29%), Positives = 315/706 (44%), Gaps = 49/706 (6%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +  ++N       TPL++AA     ++++ L+ +GA  +       TPL  A+   
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174

Query: 61  SEEAVQVLIK-------------------------------HSAD------VNARDKNWQ 83
             +AV +L++                               H+AD      VN   ++  
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 84  TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
           TPLH+AA    V  A +++   ++V+ + R G T LH A+  G+  MV LLL +G  I+A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
             +     LH AA  GH  VV LL+  GA +  + K G +PLH AA    +  VKHLL  
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 204 GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
              +D++ +   TALH+A + G   V   L+D  AN N    NGFTPLH A         
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR-IKV 413

Query: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
           +ELLV  GA +   ++ G +P+H+ A  G       L+QNG   D  +  G T LH+AAR
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
            G   ++  L  +GA           PLH+A+    ++  + LL      D     G T 
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 533

Query: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
           LH +A  G V+   +L  +GA      K G TPLH AA        + L+   A  +   
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593

Query: 444 DWGRTALHYAAASDMDRNKTIL----GNAHDNSEELERARELKEKEATLCL-EFLLQNDA 498
             G T LH AA  D  +   +L     + H  ++       +  K+  + +   LL   A
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558
             +I  K+G   +H A+  GH   + LLL++  +    + SG T   LHLAA        
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS--LHLAAQEDKVNVA 711

Query: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI 618
           ++L +   D D   + G T L +A   G+ + V  L+  GA++  K      TPLH +  
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQ 770

Query: 619 NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
            GHT  + +LL+    P A     A G T L +A   G+I  V  L
Sbjct: 771 QGHTHIINVLLQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 813



 Score =  226 bits (575), Expect = 1e-58
 Identities = 200/669 (29%), Positives = 279/669 (41%), Gaps = 92/669 (13%)

Query: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
           D N     AAR G+   +      G D   C  + +  LHLAA   H    ++LL  G  
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
           +D+  K G T LH A+  G  E +K+L   GA+ + + + G TPL+ AA   H   ++ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTI---LGNAHDNSEELERARELKEKEATLC 489
           +  GAN +   + G T L  A A     N+ +   L N       L        K+ T  
Sbjct: 150 LENGANQSTATEDGFTPL--AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 207

Query: 490 LEFLLQNDANPSIRDK--------EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
              LLQND N  ++ K         G+  +H AA YG+     LLL R  +    + +G 
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 542 TK-------------------------------SPLHLAAYNGHHQALEVLLQSLVDLDI 570
           T                                +PLH AA +GH Q +E+LL+    L  
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLL 628
           R + G + L +AA   H ECV+ L+   A +   D+VT    T LH +   GH    +LL
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPV---DDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 629 LEIADNPEA------------------------------VDVKDAKGQTPLMLAVAYGHI 658
           L+   NP A                              +      G TP+ +A   GH+
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
           + V LLL+  A+ D  +I G TALH     G  E V+ LL     +  +    +TPLH A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
           +  G  T + +LL   ++  D       GYTPLH +   G  +   VLLE          
Sbjct: 505 SRLGK-TEIVQLLLQHMAHPDAA--TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561

Query: 779 P-FTPLHCAIINDHGNCASLLL---GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLL 834
             FTPLH A      + A LLL    A DS+        G TPL  AA  D+ +   LLL
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSA-----GKNGLTPLHVAAHYDNQKVALLLL 616

Query: 835 RHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHE 894
              A  +A   +G T L +AA+  Q      L+N   A+  +  K   TPLHLA  +GH 
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG-AETNIVTKQGVTPLHLASQEGHT 675

Query: 895 KCALLILDK 903
               L+LDK
Sbjct: 676 DMVTLLLDK 684



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 58/174 (33%), Positives = 84/174 (48%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L++   + N +  +  TPLH+A+  G  +++ LL+  GA ++      LT LH A     
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
                +L KH AD +A  K   TPL VA     VK    ++   ++VN   + G T LH 
Sbjct: 708 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
           AA  GH  ++N+LL  GA  NA       AL  A  +G++ VV  L     EVT
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  303 bits (776), Expect = 5e-82
 Identities = 226/708 (31%), Positives = 348/708 (49%), Gaps = 56/708 (7%)

Query: 11   TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL----TPLHRAVAS---RSEE 63
            T  ++  TPL    F      + L+  +     A+  +W+    TP+  ++++   + +E
Sbjct: 441  TCQAKNLTPLEAQEFA-----LHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQE 495

Query: 64   AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
             +Q+L+K  A VN+ D   +T   V  A +       ++   +SVN  D  GRT L +AA
Sbjct: 496  VLQLLVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAA 553

Query: 124  LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
             +G +++VNLL+++GA++   D      L  AA  GH  VV  LI  GA +   D+ G+T
Sbjct: 554  YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613

Query: 184  PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
             L +AA  G   VV  LL  GV++D  +    TAL  A + G + +V  L+ +GA VN+ 
Sbjct: 614  ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673

Query: 244  NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV-----HGRFTRSQ 298
            +N G T L  AA   H  + +E L+++GA+VN +  DG++ L + A+      G  +   
Sbjct: 674  DNEGRTALIAAAYMGHREI-VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 299  TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
             LI  G E+D  DKDG TPL VAA  GH  +++ L   GAD      +   PL  AA   
Sbjct: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792

Query: 359  HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418
            H+     LL  G  +D+ D  GRT L  A+A GNVE ++ L   G D + +D  G TPLH
Sbjct: 793  HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852

Query: 419  YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478
             AA   H    E L+  GA  NE D+ GR                IL +   + +     
Sbjct: 853  MAAFEGHRLICEALIEQGARTNEIDNDGRIPF-------------ILASQEGHYD----- 894

Query: 479  RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEES 537
                      C++ LL+N +N   R  +G N++  AA  GHR  +ELL     +   +++
Sbjct: 895  ----------CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944

Query: 538  DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
            D   T   L++ A        E  L++  +++  D +GRTAL ++ ++GH E V+ LI  
Sbjct: 945  DGRPT---LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 598  GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657
             A +   DN  KR+ L ++   GH   ++LL+E   +   VD    +G T L +A   GH
Sbjct: 1002 HADVNAADN-EKRSALQSAAWQGHVKVVQLLIE---HGAVVDHTCNQGATALCIAAQEGH 1057

Query: 658  IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705
            ID V +LLE  A+ +  D  G TA+      GH + +++L +   S L
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105



 Score =  253 bits (647), Expect = 4e-67
 Identities = 203/664 (30%), Positives = 300/664 (45%), Gaps = 41/664 (6%)

Query: 84   TPLHVAAANKAVKCAEVIIPLLSS-VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN 142
            TP+  + +    K  EV+  L+ +  +V+    RT+          + +  LL  GA++N
Sbjct: 480  TPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVN 539

Query: 143  AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
              D   R  L  AAY G LDVV LL++ GA++  +D  G+TPL  AA  G   VV  L+ 
Sbjct: 540  QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599

Query: 203  LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
             G  I+  +  G TAL  A + G   VV+ L+  G  V+  + +  T L  AA   H  +
Sbjct: 600  CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDI 659

Query: 263  CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 322
             L LL  +GA+VN    +G++ L   A  G     + L+ +G E++  D DG T L VAA
Sbjct: 660  VLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718

Query: 323  -----RYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPD 377
                   GH  +++ L   GA+   C    M PL +AA   H D    LL  G ++D  D
Sbjct: 719  LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778

Query: 378  KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
              GRT L AAA+ G+   +  L   GA     D  GRT L  A+A  +   + TL+  G 
Sbjct: 779  NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 838

Query: 438  NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497
            + N  DD G T LH AA                            E    +C E L++  
Sbjct: 839  DENHRDDAGWTPLHMAAF---------------------------EGHRLIC-EALIEQG 870

Query: 498  ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557
            A  +  D +G      A+  GH  C+++LLE  ++  +    G  ++ L +AA  GH   
Sbjct: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG--RNALRVAALEGHRDI 928

Query: 558  LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617
            +E+L     D++ +D  GR  L + A +      E  +  GA++   D    RT LH S 
Sbjct: 929  VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD-AEGRTALHVSC 987

Query: 618  INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 677
              GH   +++L+    +   V+  D + ++ L  A   GH+  V LL+E  A VD     
Sbjct: 988  WQGHMEMVQVLIAYHAD---VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ 1044

Query: 678  GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE 737
            G TAL      GH + VQ+LLE        D  GRT +  AA  GH+  +  L +   S 
Sbjct: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS 1104

Query: 738  EDCC 741
             + C
Sbjct: 1105 LNGC 1108



 Score =  248 bits (634), Expect = 1e-65
 Identities = 227/812 (27%), Positives = 347/812 (42%), Gaps = 133/812 (16%)

Query: 129  EMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAA 188
            E++ LL+  GA++N+ D  DR +      +   D +  L+++GA V   D  G T L  A
Sbjct: 495  EVLQLLVKAGAHVNSED--DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 189  ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
            A +G ++VV  L++ G +++  + +G+T L +A   G   VVN LI  GAN+N  + +G+
Sbjct: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 249  TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
            T L  AA   H  +   LL   G  V+    D ++ L   A  G       L+Q+G E++
Sbjct: 613  TALRSAAWGGHTEVVSALLYA-GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 309  CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL-----NAHSDCC 363
              D +G T L  AA  GH  ++  L   GA+     +     L +AAL       H+   
Sbjct: 672  KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731

Query: 364  RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423
              L+  G E+D  DK G T L  AA  G+V+ + LL   GAD    D  GRTPL  AA+ 
Sbjct: 732  SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASM 791

Query: 424  CHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKE 483
             H   + TL+  GA V+  D  GRT L  A+A          GN                
Sbjct: 792  GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ---------GNVE-------------- 828

Query: 484  KEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK 543
                  +  LL    + + RD  G+  +H AA  GHR   E L+E+     E  + G  +
Sbjct: 829  -----VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG--R 881

Query: 544  SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
             P  LA+  GH+  +++LL++  ++D R   GR AL +AA +GH + VE L + GA    
Sbjct: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD--- 938

Query: 604  KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
                                              V+ KDA G+  L +      +     
Sbjct: 939  ----------------------------------VNCKDADGRPTLYILALENQLTMAEY 964

Query: 664  LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
             LE  ANV+  D  G TALH     GH E VQ+L+     +   D+  R+ L  AA +GH
Sbjct: 965  FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024

Query: 724  ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPL 783
               +  L++     +  C   NQG T L  A   G+ + ++VLLE             P 
Sbjct: 1025 VKVVQLLIEHGAVVDHTC---NQGATALCIAAQEGHIDVVQVLLEHGA---------DPN 1072

Query: 784  HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA----- 838
            H                          D  GRT +R AA   H + ++LL ++ A     
Sbjct: 1073 HA-------------------------DQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNG 1107

Query: 839  ----PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQA----DLTVKDKDL-NTPLHLAC 889
                PV+ ++     +L     + +  ++ I  NS+ +    D+    + L N P H   
Sbjct: 1108 CSPSPVHTMEQKPLQSL-----SSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFS 1162

Query: 890  SKGHEKCALLILDK--IQDESLINEKNNALQT 919
            S      + +   K  + + SL + KN++L+T
Sbjct: 1163 SPSESPDSTVDRQKSSLSNNSLKSSKNSSLRT 1194



 Score =  214 bits (546), Expect = 2e-55
 Identities = 144/442 (32%), Positives = 225/442 (50%), Gaps = 6/442 (1%)

Query: 2    LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV---- 57
            L+    +VN  D+E RT L  AA++G  EI+E L+  GA VN +D    T L  A     
Sbjct: 663  LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722

Query: 58   ASRSEEAV-QVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGR 116
            AS+   +V  +LI   A+V+  DK+  TPL VAA    V   ++++   + V+ +D  GR
Sbjct: 723  ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782

Query: 117  TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
            T L  AA  GH  +VN LL  GA +++ D + R  L  A+  G+++VV  L++ G +   
Sbjct: 783  TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842

Query: 177  KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
            +D  G+TPLH AA  G   + + L+  G   +EI+  G     +A   G    V  L++ 
Sbjct: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902

Query: 237  GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
             +N++Q   +G   L  AA   H  + +ELL ++GADVN +  DG+  L++ A+  + T 
Sbjct: 903  KSNIDQRGYDGRNALRVAALEGHRDI-VELLFSHGADVNCKDADGRPTLYILALENQLTM 961

Query: 297  SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            ++  ++NG  ++  D +G T LHV+   GH  ++  L    AD           L  AA 
Sbjct: 962  AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021

Query: 357  NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
              H    + L+  G  +D     G T L  AA  G+++ +++L   GAD +  D+ GRT 
Sbjct: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081

Query: 417  LHYAAANCHFHCIETLVTTGAN 438
            +  AA N H   I+ L   GA+
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGAS 1103



 Score =  183 bits (464), Expect = 7e-46
 Identities = 119/362 (32%), Positives = 182/362 (50%), Gaps = 5/362 (1%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +L+    DV+  D+  RTPL  AA +G A ++  L+  GA V++ D+   T L  A A  
Sbjct: 766  LLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQG 825

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
            + E V+ L+    D N RD    TPLH+AA        E +I   +  N  D  GR    
Sbjct: 826  NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI 885

Query: 121  HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
             A+  GH + V +LL   +NI+      R AL  AA  GH D+V LL +HGA+V CKD  
Sbjct: 886  LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945

Query: 181  GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
            G   L+  A   Q+ + ++ L  G  ++  +  G TALH++C+ G   +V  LI Y A+V
Sbjct: 946  GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005

Query: 241  NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
            N  +N   + L  AA   H    ++LL+ +GA V+     G + L + A  G     Q L
Sbjct: 1006 NAADNEKRSALQSAAWQGH-VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064

Query: 301  IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADT----AKCGIHSMFPLHLAAL 356
            +++G + +  D+ G T + VAA+ GH  +I  L   GA +    +   +H+M    L +L
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSL 1124

Query: 357  NA 358
            ++
Sbjct: 1125 SS 1126


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  300 bits (769), Expect = 3e-81
 Identities = 246/844 (29%), Positives = 375/844 (44%), Gaps = 64/844 (7%)

Query: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
           L  A A   E+A+   IK+  D+N  ++N    LH+A+    V+    ++   ++V+ + 
Sbjct: 46  LRAARAGHLEKALDY-IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104

Query: 113 RGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172
           + G TALH A+L G  E+V +L+  GAN+NA  +     L+ AA   HL+VV  L+++GA
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164

Query: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232
             +   + G+TPL  A   G   VV  LL    E D        ALHIA           
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAAL 220

Query: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVH 291
           L+    N +  + +GFTPLH AA   +G +    LL+N  A V+  +++  +PLH+ +  
Sbjct: 221 LLQNDNNADVESKSGFTPLHIAA--HYGNINVATLLLNRAAAVDFTARNDITPLHVASKR 278

Query: 292 GRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPL 351
           G     + L+  G +ID   +DG TPLH  AR GHE ++  L    A       + + PL
Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPL 338

Query: 352 HLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 411
           H+A    H +C + LL     +D       T LH AA  G+ +  K+L    A+ + K  
Sbjct: 339 HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398

Query: 412 CGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDR--NKTILGNAH 469
            G TPLH A        +E L+  GA++    + G T +H AA        ++ +   A 
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458

Query: 470 DNSEEL--ERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
            N+  +  E A  +  +      + +L+Q+ A    + K+    +H +A  G    ++ L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518

Query: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
           L++  S    + SG T  PLHL+A  GH      LL     L I  +KG T L +AA  G
Sbjct: 519 LQQGASPNAATTSGYT--PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576

Query: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
             E    L+   AS    D   K   TPLH +    +     LLL+   +P A       
Sbjct: 577 KLEVANLLLQKSAS---PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA---AKN 630

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
           G TPL +A     +D  + LLE  A+ + V   G  ++H     GH + V +LL +  ++
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690

Query: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
              +  G TPLH AA       ++E+L    +  D   +   GYTPLH  C+ GN   + 
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVN-VAEVLVNQGAHVDA--QTKMGYTPLHVGCHYGNIKIVN 747

Query: 765 VLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824
            LL+               H A +N                    +   G TPL  AA  
Sbjct: 748 FLLQ---------------HSAKVN-------------------AKTKNGYTPLHQAAQQ 773

Query: 825 DHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD---ILVNSAQADLTVKDK-D 880
            H   + +LL+++A  N +  +G TAL +A   G    VD   I+        TV +K  
Sbjct: 774 GHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHK 833

Query: 881 LNTP 884
           +N P
Sbjct: 834 MNVP 837



 Score =  300 bits (767), Expect = 5e-81
 Identities = 229/776 (29%), Positives = 355/776 (45%), Gaps = 52/776 (6%)

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           AA  GHL+     I +G ++   ++ G   LH A+  G + VV  LL     +D     G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
           NTALHIA   GQ  VV  L+  GANVN  + NGFTPL+ AA   H  + ++ L++NGA  
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV-VKFLLDNGASQ 166

Query: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305
           ++ ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDN 226

Query: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
             D   K G TPLH+AA YG+  +   L    A       + + PLH+A+   +++  + 
Sbjct: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286

Query: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
           LL  G +ID   + G T LH  A  G+ + +++L    A    K K G +PLH A    H
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346

Query: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELERARELK- 482
            +C++ L+     V++  +   TALH AA     +   +L    A+ N++ L     L  
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406

Query: 483 --EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
             +K     +E LL++ A+     + G   IH AA  GH   +  L+    S    +  G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
            T   LH+AA +G  + +  L+Q    ++ + +  +T L ++A  G  + V+ L+  GAS
Sbjct: 467 ETA--LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524

Query: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
                  +  TPLH S   GH      LL   D+  ++ +   KG TPL +A  YG ++ 
Sbjct: 525 PNAA-TTSGYTPLHLSAREGHEDVAAFLL---DHGASLSITTKKGFTPLHVAAKYGKLEV 580

Query: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720
            +LLL+K A+ D     G T LH      +++   +LL+Q  S       G TPLH AA 
Sbjct: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640

Query: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP- 779
           +      + LL+      D      QG   +H A   G+ + + +LL +           
Sbjct: 641 KNQMDIATTLLEYGA---DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697

Query: 780 FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
            TPLH A   D  N A +L+     + V  +   G TPL       +++ +  LL+HSA 
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVN--QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755

Query: 840 VNAVDNSGKTALMMAAENGQAGAVDILV--NSAQADLTVKDKDLNTPLHLACSKGH 893
           VNA   +G T L  AA+ G    +++L+  N++  +LTV     NT L +A   G+
Sbjct: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG---NTALGIARRLGY 808



 Score =  299 bits (766), Expect = 7e-81
 Identities = 220/746 (29%), Positives = 341/746 (45%), Gaps = 43/746 (5%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+ +  +V+    +  T LH+A+  G AE++++L+ +GA VNA+     TPL+ A     
Sbjct: 93  LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
            E V+ L+ + A  +   ++  TPL VA      +  + ++ LL   +   +    ALH 
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQ----QGHDQVVSLLLENDTKGKVRLPALHI 208

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
           AA     +   LLL    N +   K     LH AA+ G+++V  LL+N  A V    +  
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268

Query: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
            TPLH A+  G  N+VK LL+ G +ID     G T LH    +G + VV  L+D  A + 
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
               NG +PLH A    H   C++LL+ +   V+  + D  + LH+ A  G +  ++ L+
Sbjct: 329 SKTKNGLSPLHMATQGDH-LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387

Query: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
                 +    +G TPLH+A +     ++  L   GA         + P+H+AA   H +
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
              +L+  G   +T +  G T LH AA  G  E ++ L   GA    K K  +TPLH +A
Sbjct: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
                  ++ L+  GA+ N     G T LH +                        ARE 
Sbjct: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLS------------------------AREG 543

Query: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
            E  A     FLL + A+ SI  K+G+  +H AA YG  +   LLL+++ S      SG 
Sbjct: 544 HEDVAA----FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
           T  PLH+AA+  + +   +LL          + G T L +AA K   +    L+  GA  
Sbjct: 600 T--PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD- 656

Query: 602 FVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
              + VT++    +H +   GH   + LLL    N   V++ +  G TPL LA     ++
Sbjct: 657 --ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVN 711

Query: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
              +L+ + A+VD    +G T LH G   G+ + V  LL+    +  K   G TPLH AA
Sbjct: 712 VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAA 771

Query: 720 ARGHATWLSELLQMALSEEDCCFKDN 745
            +GH   ++ LLQ   S  +     N
Sbjct: 772 QQGHTHIINVLLQNNASPNELTVNGN 797



 Score =  266 bits (679), Expect = 9e-71
 Identities = 203/682 (29%), Positives = 304/682 (44%), Gaps = 43/682 (6%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           TPL VA   G  +++ LL+ +    + K  + L  LH A      +A  +L+++  + + 
Sbjct: 175 TPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV 230

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
             K+  TPLH+AA    +  A +++   ++V+ + R   T LH A+  G+  MV LLL +
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290

Query: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
           GA I+A  +     LH  A  GH  VV +L++  A +  K K G +PLH A     +N V
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV 350

Query: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257
           + LL   V +D++     TALH+A + G   V   L+D  AN N    NGFTPLH A   
Sbjct: 351 QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKK 410

Query: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTP 317
                 +ELL+ +GA +   ++ G +P+H+ A  G       L+ +G   +  +  G T 
Sbjct: 411 NR-IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 469

Query: 318 LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPD 377
           LH+AAR G   ++  L   GA           PLH++A    +D  ++LL  G   +   
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 378 KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
             G T LH +A  G+ +    L   GA      K G TPLH AA          L+   A
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589

Query: 438 NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497
           + +     G T LH AA  D                         +K A L    LL   
Sbjct: 590 SPDAAGKSGLTPLHVAAHYD------------------------NQKVALL----LLDQG 621

Query: 498 ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557
           A+P    K GY  +H AA          LLE        +  G   + +HLAA  GH   
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI--ASVHLAAQEGHVDM 679

Query: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR--TPLHA 615
           + +LL    ++++ ++ G T L LAA +      E L+N GA +   D  TK   TPLH 
Sbjct: 680 VSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV---DAQTKMGYTPLHV 736

Query: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVD 675
               G+   +  LL+   +   V+ K   G TPL  A   GH   +++LL+  A+ + + 
Sbjct: 737 GCHYGNIKIVNFLLQ---HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELT 793

Query: 676 ILGCTALHRGIMTGHEECVQML 697
           + G TAL      G+   V  L
Sbjct: 794 VNGNTALGIARRLGYISVVDTL 815



 Score =  266 bits (679), Expect = 9e-71
 Identities = 167/542 (30%), Positives = 269/542 (49%), Gaps = 29/542 (5%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +   ++    +  TPLH  A  G  +++E+L+   A + +K    L+PLH A    
Sbjct: 286 LLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
               VQ+L++H+  V+    ++ T LHVAA     K A+V++   ++ N     G T LH
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            A     ++++ LLL  GA+I A  +     +H AA+MGH+++V+ L++HGA     + +
Sbjct: 406 IACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G T LH AA +GQ  VV++L+  G +++       T LHI+   G+  +V +L+  GA+ 
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N    +G+TPLH +A   H  +    L+++GA ++I +K G +PLH+ A +G+   +  L
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVA-AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           +Q     D   K G TPLHVAA Y ++ +   L   GA       +   PLH+AA     
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
           D    LL  G + +   + G   +H AA  G+V+ + LL    A+ +  +K G TPLH A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
           A     +  E LV  GA+V+     G T LH             +G  + N +       
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH-------------VGCHYGNIK------- 744

Query: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    + FLLQ+ A  + + K GY  +H AA  GH   + +LL+   S  E + +G
Sbjct: 745 --------IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG 796

Query: 541 AT 542
            T
Sbjct: 797 NT 798



 Score =  263 bits (672), Expect = 6e-70
 Identities = 186/593 (31%), Positives = 278/593 (46%), Gaps = 11/593 (1%)

Query: 10  NTLDSEKR---TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
           N  D E +   TPLH+AA  G+  +  LL+   A V+      +TPLH A    +   V+
Sbjct: 226 NNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVK 285

Query: 67  VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG 126
           +L+   A ++A+ ++  TPLH  A +   +  E+++   + +    + G + LH A    
Sbjct: 286 LLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345

Query: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186
           H+  V LLL     ++        ALH AA+ GH  V  +L++  A    K   G+TPLH
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405

Query: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
            A    +I V++ LL  G  I  +   G T +H+A + G   +V++L+ +GA+ N  N  
Sbjct: 406 IACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465

Query: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306
           G T LH AA S   A  +  LV +GA V  ++KD ++PLH++A  G+    Q L+Q G  
Sbjct: 466 GETALHMAARSGQ-AEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524

Query: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
            +     G TPLH++AR GHE +   L   GA  +        PLH+AA     +    L
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584

Query: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426
           L      D   K G T LH AA   N +   LL   GA  H   K G TPLH AA     
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 427 HCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILG-NAH---DNSEELERAREL 481
               TL+  GA+ N     G  ++H AA    +D    +LG NA+    N   L      
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704

Query: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
            +++     E L+   A+   + K GY  +H    YG+ + +  LL+ +     ++ +G 
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
           T  PLH AA  GH   + VLLQ+    +     G TAL +A   G+   V+ L
Sbjct: 765 T--PLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  214 bits (545), Expect = 3e-55
 Identities = 185/665 (27%), Positives = 279/665 (41%), Gaps = 74/665 (11%)

Query: 313 DGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
           D N     AAR GH E  ++ ++ +G D   C  + +  LHLA+   H +   +LL    
Sbjct: 40  DANASYLRAARAGHLEKALDYIK-NGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98

Query: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
            +D   K G T LH A+  G  E +K+L ++GA+ + + + G TPL+ AA   H   ++ 
Sbjct: 99  NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 158

Query: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTIL-GNAHDNSEELERARELKEKEATLCL 490
           L+  GA+ +   + G T L  A     D+  ++L  N       L        K+ T   
Sbjct: 159 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAA 218

Query: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAA 550
             LLQND N  +  K G+  +H AA YG+     LLL R  +    + +  T  PLH+A+
Sbjct: 219 ALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT--PLHVAS 276

Query: 551 YNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK------ 604
             G+   +++LL     +D +   G T L   A  GH + VE L++  A I  K      
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336

Query: 605 ------------------------DNVTKR--TPLHASVINGHTLCLRLLLEIADNPEA- 637
                                   D+VT    T LH +   GH    ++LL+   NP A 
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396

Query: 638 -----------------------------VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
                                        +      G TP+ +A   GH++ VS L+   
Sbjct: 397 ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           A+ +T ++ G TALH    +G  E V+ L++    +  K    +TPLH +A  G A  + 
Sbjct: 457 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516

Query: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAI 787
           +LLQ   S          GYTPLH +   G+E+    LL+            FTPLH A 
Sbjct: 517 QLLQQGASPNAAT---TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573

Query: 788 INDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSG 847
                  A+LLL    S+        G TPL  AA  D+ +   LLL   A  +A   +G
Sbjct: 574 KYGKLEVANLLLQK--SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 848 KTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDE 907
            T L +AA+  Q      L+    AD     +     +HLA  +GH     L+L +  + 
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYG-ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690

Query: 908 SLINE 912
           +L N+
Sbjct: 691 NLSNK 695



 Score =  201 bits (512), Expect = 2e-51
 Identities = 123/353 (34%), Positives = 186/353 (52%), Gaps = 1/353 (0%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+H     NT +    T LH+AA  G AE++  L+  GA+V AK     TPLH +     
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
            + VQ L++  A  NA   +  TPLH++A       A  ++   +S++++ + G T LH 
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
           AA  G +E+ NLLL K A+ +A  K     LH AA+  +  V  LL++ GA      K G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
           YTPLH AA   Q+++   LL  G + + +   G  ++H+A   G   +V+ L+   ANVN
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
             N +G TPLH AA      +  E+LVN GA V+ Q+K G +PLH+   +G       L+
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVA-EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750

Query: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354
           Q+  +++   K+G TPLH AA+ GH  +IN L  + A   +  ++    L +A
Sbjct: 751 QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIA 803



 Score =  166 bits (420), Expect = 9e-41
 Identities = 107/339 (31%), Positives = 163/339 (48%), Gaps = 34/339 (10%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+ +    N   +   TPLH++A  G  ++   L+  GA ++       TPLH A     
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
            E   +L++ SA  +A  K+  TPLHVAA     K A +++   +S + + + G T LH 
Sbjct: 578 LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637

Query: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
           AA    +++   LL  GA+ NA  ++   ++H AA  GH+D+V+LL+   A V   +K G
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697

Query: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
            TPLH AA   ++NV + L+N G  +D     G T LH+ C+ G   +VN L+ + A VN
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
               NG+TPLH AA   H  +   LL NN            SP  +T             
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNA-----------SPNELTV------------ 794

Query: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADT 340
                      +GNT L +A R G+  +++TL+    +T
Sbjct: 795 -----------NGNTALGIARRLGYISVVDTLKIVTEET 822



 Score =  158 bits (399), Expect = 3e-38
 Identities = 144/521 (27%), Positives = 230/521 (44%), Gaps = 96/521 (18%)

Query: 454 AASDMDRNKTILGNAHDNSEELERAREL---KEKEATLCLEFL--------------LQN 496
           AAS + +N+ +  NA +  E+  + R+    ++K++     +L              ++N
Sbjct: 4   AASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKN 63

Query: 497 DANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK---SPLHLAAYNG 553
             + +I ++ G N++H A+  GH + +  LL+R     E +   ATK   + LH+A+  G
Sbjct: 64  GVDINICNQNGLNALHLASKEGHVEVVSELLQR-----EANVDAATKKGNTALHIASLAG 118

Query: 554 HHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS--IFVKDNVTKRT 611
             + ++VL+ +  +++ + + G T L +AA + H E V+ L++ GAS  +  +D  T   
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFT--- 175

Query: 612 PLHASVINGHTLCLRLLLE--------------------------IADNPEAVDVKDAKG 645
           PL  ++  GH   + LLLE                          +  N    DV+   G
Sbjct: 176 PLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSG 235

Query: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705
            TPL +A  YG+I+  +LLL + A VD       T LH     G+   V++LL++   I 
Sbjct: 236 FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295

Query: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 765
            K   G TPLH  A  GH   +  LL  A        K   G +PLH A    + NC+++
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAP---ILSKTKNGLSPLHMATQGDHLNCVQL 352

Query: 766 LLEQKCFRKFIGNPF-TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824
           LL+       + N + T LH A    H   A +LL     +  + +   G TPL  A   
Sbjct: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK--KANPNAKALNGFTPLHIACKK 410

Query: 825 DHVECLQLLLRHSAPVNAVDNS---------------------------------GKTAL 851
           + ++ ++LLL+H A + AV  S                                 G+TAL
Sbjct: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470

Query: 852 MMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKG 892
            MAA +GQA  V  LV    A +  K KD  TPLH++   G
Sbjct: 471 HMAARSGQAEVVRYLVQDG-AQVEAKAKDDQTPLHISARLG 510


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  248 bits (634), Expect = 1e-65
 Identities = 252/891 (28%), Positives = 394/891 (44%), Gaps = 79/891 (8%)

Query: 38   SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 97
            S A     DN  L     A +     AV+ L+     VN   +  ++ L +A +    + 
Sbjct: 226  STANAGQSDNRSLA---EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL 282

Query: 98   AEVIIPLLSSVNVSDRGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 154
            A+V++ +    NV DRG +   T L  AA  GHV++V LLLA  A++NA       AL +
Sbjct: 283  AQVLLAM--HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340

Query: 155  AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVY 213
            A   G++DVV +L+  GA +   ++ G+TPL  A S G + V + LL  G  I+   N +
Sbjct: 341  ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400

Query: 214  GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
              +AL +ACY G   +V  L++ GA+     +   T L  A    H  +   LL+++GA 
Sbjct: 401  KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQ 459

Query: 274  VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
            VN+ +   +SPL + A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L
Sbjct: 460  VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519

Query: 334  RTSGAD-TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392
               GA+  A+        L LA      +    L+ +G +I+       T L  AA  G+
Sbjct: 520  LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576

Query: 393  VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452
            +E +K L ++GA+ H     G T L YA  N H    + L+  GA++    + GRT L  
Sbjct: 577  LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 453  AA------------ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANP 500
            AA            +   + N+T   N H           L        +E LL + A+P
Sbjct: 637  AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA------VVELLLAHGADP 690

Query: 501  SIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK--SPLHLAAYNGHHQAL 558
            + R K+G   +  AA  GH   +  LL+  N+         T+   P H       ++A 
Sbjct: 691  THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSH-----DLNRAP 745

Query: 559  EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI 618
             V +Q+L  +    E  +   ++A           L     ++  + +    TP H+   
Sbjct: 746  RVPVQALPMVVPPQEPDKPPANVAT---------TLPIRNKAVSGRASAMSNTPTHSIAA 796

Query: 619  NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG 678
            +         +     P    +       P+  A+    IDA     + E+N DT   L 
Sbjct: 797  S---------ISQPQTPTPSPIISPSAMLPIYPAI---DIDA-----QTESNHDTALTLA 839

Query: 679  CTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEE 738
            C         GHEE VQ LLE+  SI  +D +G TPL  AA  GH   +  LL      E
Sbjct: 840  CAG-------GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892

Query: 739  DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGNCASL 797
                 +    TPL  AC  G +  +E+LL +   ++    + +TPL  A    + N   +
Sbjct: 893  --AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950

Query: 798  LLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHSAPVNA-VDNSGKTALMMAA 855
            LL A  + I S    K G +PL  AA   H   ++LLL   + +NA ++ +  TAL +A 
Sbjct: 951  LLNA-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 856  ENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906
              G+   V +L++  +A++  + K   TPL  A S G+ +   ++LDK  D
Sbjct: 1010 FQGRTEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059



 Score =  213 bits (543), Expect = 5e-55
 Identities = 232/850 (27%), Positives = 369/850 (43%), Gaps = 81/850 (9%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +L HK  DVN   S   T L  A   G  +++++L+ SGA +   +    TPL  A ++ 
Sbjct: 320  LLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378

Query: 61   SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
              E  ++L+++ A +N     + ++ L +A     ++    ++   +          TAL
Sbjct: 379  HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438

Query: 120  HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
              A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 439  MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498

Query: 180  KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
            +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 499  EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558

Query: 239  NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
            ++    +   TPL  AA   H  L ++ L+  GA+V+  +  G + L     +G    + 
Sbjct: 559  DIELGCS---TPLMEAAQEGHLEL-VKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614

Query: 299  TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD---TAKCGIHSMFPLHLAA 355
             L+Q G +++   + G TPL  AAR GH   +  L + GA+   T     H++  L LA 
Sbjct: 615  VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV--LSLAC 672

Query: 356  LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI--------KLLQSSGADF- 406
               H      LL+ G +     K G T L  AA GG+   +         LL +   D  
Sbjct: 673  AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVT 732

Query: 407  ------HKKDKCGRTPLH---------------------------------YAAANCHFH 427
                  H  ++  R P+                                   A +N   H
Sbjct: 733  QLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTH 792

Query: 428  CIETLVTTGANVNETDDWGRTA-LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 486
             I   ++       +     +A L    A D+D       + HD +  L  A   +E   
Sbjct: 793  SIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE---SNHDTALTLACAGGHEELVQ 849

Query: 487  TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SP 545
            TL     L+  A+   RDK+G+  +  AA  GH   +E+LL+  N    E+ S  TK +P
Sbjct: 850  TL-----LERGASIEHRDKKGFTPLILAATAGHVGVVEILLD--NGADIEAQSERTKDTP 902

Query: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK- 604
            L LA   G  + +E+LL    + + R+    T L LAA  G+   ++ L+N GA I  + 
Sbjct: 903  LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962

Query: 605  DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
             +    +PL  + +NGHT  ++LLL++  +  A    +    T L LA   G  + VSLL
Sbjct: 963  GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA--QIETNRNTALTLACFQGRTEVVSLL 1020

Query: 665  LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARG 722
            L+++ANV+     G T L      G+ E  ++LL++  +V+     S   T L  AA +G
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080

Query: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN-PFT 781
            H  +   L+      +    ++ +G TPL  A   G+ + +++L++         N   T
Sbjct: 1081 HYKFCELLIGRGAHID---VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137

Query: 782  PLHCAIINDH 791
            PL  A    H
Sbjct: 1138 PLMAAFRKGH 1147



 Score =  195 bits (496), Expect = 1e-49
 Identities = 248/960 (25%), Positives = 387/960 (40%), Gaps = 110/960 (11%)

Query: 4    HKTEDVNTLDSEKRTPLHVAAFLGDAEIIE--------LLILSGARVNAKDNMWLTPLHR 55
            + +E+    D E+     V +F+ D + +E         L+LSG    A D   + P  +
Sbjct: 114  NNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGA-DLRTVDPETQ 172

Query: 56   AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA--EVIIPLL-----SSV 108
            A      EA  +    +AD     K +  P  +     +V CA  E    L      S+ 
Sbjct: 173  ARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTA 228

Query: 109  NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168
            N      R+ L  A   G V  V  LL +G ++N   ++    L  A   G+ ++  +L+
Sbjct: 229  NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287

Query: 169  NHGAEVTCKDKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227
               A V  +  KG  TPL AAA+ G + +VK LL    +++  +  GNTAL  AC  G  
Sbjct: 288  AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347

Query: 228  AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287
             VV  L++ GA++   N NG TPL  A ++ H  +   LL+ NGA +N  S + K     
Sbjct: 348  DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFK----- 401

Query: 288  TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347
                                        + L +A   GH  ++  L  +GAD        
Sbjct: 402  ---------------------------ESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434

Query: 348  MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
               L  A ++ H +  R LL SG +++ P     + L  AA GG+VE   LL   GA   
Sbjct: 435  HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494

Query: 408  KKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILG 466
            + +  G TPL  AA   H   +  L+  GAN+N +T++   TAL  A           L 
Sbjct: 495  EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554

Query: 467  NAHDNSEELERARELKE--KEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCL 523
             A  +  EL  +  L E  +E  L  +++LL   AN       G  ++ YA   GH    
Sbjct: 555  KAGADI-ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 524  ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD-IRDEKGRTALDLA 582
            ++LL+       ES+ G T  PL  AA  GH   ++ L+    +++        T L LA
Sbjct: 614  DVLLQAGADLEHESEGGRT--PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 583  AFKGHTECVEALINPGA--SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV 640
               GH   VE L+  GA  +  +KD     T L  +   GHT  +  LL+  +N  +   
Sbjct: 672  CAGGHLAVVELLLAHGADPTHRLKDG---STMLIEAAKGGHTSVVCYLLDYPNNLLSAPP 728

Query: 641  KDAKGQTPL---MLAVAYGHIDAVSLLL-EKEANVDTVDILGCTALHRGIMTGHEECVQM 696
             D    TP    +       + A+ +++  +E +    ++     +    ++G    +  
Sbjct: 729  PDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSN 788

Query: 697  LLEQEVSILCKDSRGRTP-----------------------------LHYAAARGHATWL 727
                 ++      +  TP                             L  A A GH   +
Sbjct: 789  TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 848

Query: 728  SELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHC 785
              LL+   S E    +D +G+TPL  A   G+   +E+LL+       +      TPL  
Sbjct: 849  QTLLERGASIE---HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSL 905

Query: 786  AIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDN 845
            A          LLL     +    R+    TPL  AA   +V  +++LL   A +N+   
Sbjct: 906  ACSGGRQEVVELLLAR--GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG 963

Query: 846  S--GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
            S  G + LM+AA NG   AV +L++         + + NT L LAC +G  +   L+LD+
Sbjct: 964  SKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1023



 Score =  163 bits (412), Expect = 8e-40
 Identities = 190/706 (26%), Positives = 294/706 (41%), Gaps = 81/706 (11%)

Query: 1    MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59
            +L+ +  ++N    E + T L +A   G  E+ + LI +GA +    +   TPL  A   
Sbjct: 518  LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQE 574

Query: 60   RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
               E V+ L+   A+V+A      T L  A  N     A+V++   + +     GGRT L
Sbjct: 575  GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634

Query: 120  HHAALNGHVEMVNLLLAKGANINAFD-KKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
              AA  GHV  V  L++KGAN+N      D   L  A   GHL VV LL+ HGA+ T + 
Sbjct: 635  MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL 694

Query: 179  KKGYTPLHAAASNG------------------------QINVVKHLLNLGVEID------ 208
            K G T L  AA  G                        Q+    H LN    +       
Sbjct: 695  KDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM 754

Query: 209  ----------EINVYGNTALHIACYNGQDAVVNELIDYG--ANVNQPNNNGFTPLHFAAA 256
                        NV     +     +G+ + ++    +   A+++QP     +P+   +A
Sbjct: 755  VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSA 814

Query: 257  STHGALCLELLVNNGADVNIQSKDGK-SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
                     L +    D++ Q++    + L +    G     QTL++ G  I+  DK G 
Sbjct: 815  M--------LPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF 866

Query: 316  TPLHVAARYGHELLINTLRTSGADT-AKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID 374
            TPL +AA  GH  ++  L  +GAD  A+       PL LA      +    LL+ G   +
Sbjct: 867  TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926

Query: 375  TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK--DKCGRTPLHYAAANCHFHCIETL 432
              +    T L  AA+GG V  IK+L ++GA+ + +   K G +PL  AA N H   ++ L
Sbjct: 927  HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986

Query: 433  VTTGANVNETDDWGR-TALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL--- 488
            +  G+++N   +  R TAL  A         ++L +   N E   +       EA     
Sbjct: 987  LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1046

Query: 489  --CLEFLLQNDAN------PSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                  LL   A+      PS RD     ++  AA  GH +  ELL+ R       +  G
Sbjct: 1047 AEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRNKKG 1102

Query: 541  ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
             T  PL LAA  GH   +++L+Q+  D+D  D +  T L  A  KGH + V  L+    +
Sbjct: 1103 NT--PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VN 1159

Query: 601  IFVKDNVTKR---TPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643
             F  D+   R   T     ++    LC+  +++  D   A   K+A
Sbjct: 1160 QFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1205



 Score =  145 bits (367), Expect = 1e-34
 Identities = 126/430 (29%), Positives = 198/430 (46%), Gaps = 26/430 (6%)

Query: 84   TPLHVAAAN---------KAVKCAEVIIPLLSSVNV---SDRGGRTALHHAALNGHVEMV 131
            TP H  AA+           +     ++P+  ++++   ++    TAL  A   GH E+V
Sbjct: 789  TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 848

Query: 132  NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY-TPLHAAAS 190
              LL +GA+I   DKK    L  AA  GH+ VV +L+++GA++  + ++   TPL  A S
Sbjct: 849  QTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACS 908

Query: 191  NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GF 248
             G+  VV+ LL  G   +  NV   T L +A   G   ++  L++ GA +N    +  G 
Sbjct: 909  GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 968

Query: 249  TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP-LHMTAVHGRFTRSQTLIQNGGEI 307
            +PL  AA + H A  ++LL++ G+D+N Q +  ++  L +    GR      L+     +
Sbjct: 969  SPLMLAAMNGHTA-AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1027

Query: 308  DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHSDCCRK 365
            +   K G TPL  AA  G+  +   L   GAD     + S     L +AA   H   C  
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087

Query: 366  LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
            L+  G  ID  +K G T L  AA GG+++ ++LL  +GAD    D    TPL  A    H
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147

Query: 426  FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
               +  LV     VN+         + A  +D    K +L   H   E + +A++ +  E
Sbjct: 1148 VKVVRYLV---KEVNQFPSDSECMRYIATITD----KEMLKKCHLCMESIVQAKDRQAAE 1200

Query: 486  ATLCLEFLLQ 495
            A      LL+
Sbjct: 1201 ANKNASILLE 1210



 Score =  127 bits (318), Expect = 6e-29
 Identities = 120/394 (30%), Positives = 177/394 (44%), Gaps = 39/394 (9%)

Query: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
            L LA   GH + ++ LL+    ++ RD+KG T L LAA  GH   VE L++ GA I  + 
Sbjct: 836  LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895

Query: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
              TK TPL  +   G    + LLL    N E  +V D    TPL LA + G+++ + +LL
Sbjct: 896  ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 952

Query: 666  E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
                E N  T   LG + L    M GH   V++LL+    I  + ++   T L  A  +G
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
                +S LL    + E    +   G TPL  A   G      VLL++         P   
Sbjct: 1013 RTEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069

Query: 781  -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
             T L  A    H     LL+G    + +  R+ KG TPL  AA   H++ +QLL++  A 
Sbjct: 1070 DTALTIAADKGHYKFCELLIGR--GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127

Query: 840  VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQAD-------LTVKDKDLNTPLHLA- 888
            V+A DN   T LM A   G    V  L   VN   +D        T+ DK++    HL  
Sbjct: 1128 VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCM 1187

Query: 889  ----------CSKGHEKCALLI----LDKIQDES 908
                       ++ ++  ++L+    L+K+++ES
Sbjct: 1188 ESIVQAKDRQAAEANKNASILLEELDLEKLREES 1221



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 72/278 (25%), Positives = 117/278 (42%), Gaps = 38/278 (13%)

Query: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMTGHEECVQ 695
           +V+    +G++ L LA + G+ +   +LL   ANV+   I G  T L      GH + V+
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318

Query: 696 MLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWAC 755
           +LL  +  +  + S G T L YA A G+   +  LL+   S ED    +  G+TPL  A 
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED---HNENGHTPLMEAG 375

Query: 756 YNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGR 815
             G+     +LLE                 A IN H N                  +   
Sbjct: 376 SAGHVEVARLLLENG---------------AGINTHSN------------------EFKE 402

Query: 816 TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLT 875
           + L  A +  H+E ++ LL   A      +   TALM A  +G      +L++S  A + 
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG-AQVN 461

Query: 876 VKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           +      +PL LA   GH + A L++++      +N++
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE 499



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 47/175 (26%), Positives = 73/175 (41%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCF--RKFIGNPFTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL        + I    TPL  A    H     LLL    
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLA--H 323

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A    +V+ +++LL   A +   + +G T LM A   G     
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA 383

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L+ +     T  ++   + L LAC KGH +    +L+   D E   +E + AL
Sbjct: 384 RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 3/124 (2%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +LI +   ++  + +  TPL +AA  G  ++++LL+ +GA V+A DN  +TPL  A    
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1146

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
              + V+ L+K   +VN    + +   ++A         +  + + S V   DR    A  
Sbjct: 1147 HVKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANK 1203

Query: 121  HAAL 124
            +A++
Sbjct: 1204 NASI 1207


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  238 bits (607), Expect = 2e-62
 Identities = 233/770 (30%), Positives = 335/770 (43%), Gaps = 133/770 (17%)

Query: 7   EDVNTLDS--EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64
           E VN+ D+   K TPLH AA  G  +++E L+ +GA V A+D+  L PLH A +    E 
Sbjct: 47  EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106

Query: 65  VQVLIKHSADVNARDKNWQ-TPLHVAAAN------------------------------- 92
           V +L++H AD NARD NW  TPLH AA                                 
Sbjct: 107 VNLLLRHGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165

Query: 93  ---KAVKCAE--------------------VIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
              KAV   E                    ++ PL  + + SD    T LH AA    V+
Sbjct: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225

Query: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
           +V LLL  GA+++A DK D   LH A   GH +V  LL+ HGA V   D   +TPLH AA
Sbjct: 226 IVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285

Query: 190 SNGQINVVKHLLNLGVEIDEINVYGNTAL------------------HIACYNGQDAVVN 231
           S  ++ V   LL+ G +   +N +  +A+                  H      ++A V 
Sbjct: 286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVT 345

Query: 232 ELIDY----GANVNQPNNNGFTPLHFAAASTH---GALCLELLVNNGADVNIQSKDGKSP 284
            +  +      N   P  +  T LH AAAS +     +C ELL+  GA++N ++K+  +P
Sbjct: 346 RIKKHLSLEMVNFKHPQTHE-TALHCAAASPYPKRKQIC-ELLLRKGANINEKTKEFLTP 403

Query: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344
           LH+ +        + ++++  +++ +D  G T LH AA  GH      L + G D     
Sbjct: 404 LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463

Query: 345 IHSMFPLHLAALN-----------AHSDCCRKLL--SSGFEIDTPDKF------------ 379
           +     L +   N            +S+  R+LL  +   +++T  K             
Sbjct: 464 LQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523

Query: 380 GR--TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
           GR  T LH AA    V  ++ L   GAD H KDK G  PLH A +  H+   E LV  GA
Sbjct: 524 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583

Query: 438 NVNETDDWGRTALHYAAA-SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQN 496
            VN  D W  T LH AAA    +  K +L +  D ++        K ++    L+  L  
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK--------KNRDGNTPLD--LVK 633

Query: 497 DANPSIRD-KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHH 555
           D +  I+D   G  ++  AA  G    ++ L    N    ++  G   +PLHLAA   + 
Sbjct: 634 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDT-QGRHSTPLHLAAGYNNL 692

Query: 556 QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
           +  E LLQ   D++ +D+ G   L  AA  GH +    LI   A +   D     TPLH 
Sbjct: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDK-WAFTPLHE 751

Query: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
           +   G T    LLL    +P    +K+ +GQTPL L  A    D VS LL
Sbjct: 752 AAQKGRTQLCALLLAHGADP---TLKNQEGQTPLDLVSA----DDVSALL 794



 Score =  221 bits (562), Expect = 3e-57
 Identities = 234/808 (28%), Positives = 343/808 (42%), Gaps = 87/808 (10%)

Query: 108 VNVSDRGGR--TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165
           VN  D  GR  T LH AA  G  ++V  LL  GAN+ A D      LH A   GH +VV 
Sbjct: 49  VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108

Query: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG 225
           LL+ HGA+   +D   YTPLH AA  G+I+V   LL  G E    N  G TAL +A  + 
Sbjct: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168

Query: 226 QDAVVNE---------------------LIDYGANVNQPNNNGFTPLHFAAASTHGALCL 264
           +  +  E                     L     N +  +    TPLH AA      + +
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKI-V 227

Query: 265 ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARY 324
           +LL+ +GADV+ + K    PLH    +G +  ++ L+++G  ++ +D    TPLH AA  
Sbjct: 228 QLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287

Query: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALN------AHSDCCRKLLSSGFEIDTP-- 376
               + + L + GAD      H+   + LA         A+      LL +  E D    
Sbjct: 288 NRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRI 347

Query: 377 -------------DKFGRTCLHAAAAG---GNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
                         +   T LH AAA       +  +LL   GA+ ++K K   TPLH A
Sbjct: 348 KKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVA 407

Query: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILGNAHD-NSEELERA 478
           +   H   +E +V   A VN  D+ G+T+LH AA    +   + +L    D N   L+  
Sbjct: 408 SEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGF 467

Query: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD 538
             L+       ++ LLQ     S+ + E    +  AA  G  + ++ L    +    + +
Sbjct: 468 TALQMGNEN--VQQLLQEGI--SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523

Query: 539 SGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPG 598
            G   +PLH AA       +E LLQ   D+  +D+ G   L  A   GH E  E L+  G
Sbjct: 524 -GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 599 ASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHI 658
           A + V D + K TPLH +   G     +LLL+   +P     K+  G TPL L V  G  
Sbjct: 583 AVVNVAD-LWKFTPLHEAAAKGKYEICKLLLQHGADPTK---KNRDGNTPLDL-VKDGDT 637

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR--TPLH 716
           D   LL    A +D     GC A  +             L    ++ C+D++GR  TPLH
Sbjct: 638 DIQDLLRGDAALLDAAK-KGCLARVK------------KLSSPDNVNCRDTQGRHSTPLH 684

Query: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE-QKCFRKF 775
            AA   +      LLQ      D   +D  G  PLH A   G+ +   +L++   C    
Sbjct: 685 LAAGYNNLEVAEYLLQHG---ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741

Query: 776 IGNPFTPLHCAIINDHGN-CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLL 834
               FTPLH A        CA LL    D ++   ++ +G+TPL   +  D    +  LL
Sbjct: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTL---KNQEGQTPLDLVSADD----VSALL 794

Query: 835 RHSAPVNAVDNSGKTALMMAAENGQAGA 862
             + P +A+ +  K  ++    +  A A
Sbjct: 795 TAAMPPSALPSCYKPQVLNGVRSPGATA 822



 Score =  214 bits (546), Expect = 2e-55
 Identities = 223/792 (28%), Positives = 336/792 (42%), Gaps = 105/792 (13%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYG--NTALHIACYNGQDAVVNELIDYGANVNQ 242
           L  A  NG +  VK L+    +++  +  G  +T LH A   G+  VV  L+  GANV  
Sbjct: 28  LFEACRNGDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 243 PNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
            ++ G  PLH A +  H  + + LL+ +GAD N +     +PLH  A+ G+      L+Q
Sbjct: 87  RDDGGLIPLHNACSFGHAEV-VNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA-DTAKCGIHSMFPLHLAALNA--H 359
           +G E    + DG T L +A      +L    +     ++A+ G        L  LN   H
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
           +   RK                T LH AA    V+ ++LL   GAD H KDK    PLH 
Sbjct: 206 ASDGRK---------------STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDM----------DRNKTILGNAH 469
           A +  H+   E LV  GA VN  D W  T LH AA+ +             + T+L   +
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310

Query: 470 DNSEELERARELKEKEATLCLEF----LLQNDANPSIRDKEGYNSI-------------- 511
            ++ +L    +LKE+   L  EF    LLQ      +   + + S+              
Sbjct: 311 KSAIDLAPTPQLKER---LAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETA 367

Query: 512 -HYAAAYGH---RQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVD 567
            H AAA  +   +Q  ELLL +  +  E++    T  PLH+A+   H+  +EV+++    
Sbjct: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLT--PLHVASEKAHNDVVEVVVKHEAK 425

Query: 568 LDIRDEKGRTALDLAAFKGHTECVEALINPGA----------SIFVKDNVTKRTPLHASV 617
           ++  D  G+T+L  AA+ GH +    L++ G           +     N   +  L   +
Sbjct: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGI 485

Query: 618 INGHTLCLRLLLEIAD-----------NPEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLL 664
             G++   R LLE A              ++V+ +D +G+  TPL  A  Y  +  V  L
Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYL 545

Query: 665 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHA 724
           L+  A+V   D  G   LH     GH E  ++L++    +   D    TPLH AAA+G  
Sbjct: 546 LQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605

Query: 725 TWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLH 784
                LLQ      D   K+  G TPL        +  I+ LL                 
Sbjct: 606 EICKLLLQHGA---DPTKKNRDGNTPLDLV--KDGDTDIQDLLRGDA------------- 647

Query: 785 CAIIND-HGNCASLLLGAIDSSIVSCRDDKGR--TPLRAAAFADHVECLQLLLRHSAPVN 841
            A+++     C + +        V+CRD +GR  TPL  AA  +++E  + LL+H A VN
Sbjct: 648 -ALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
           A D  G   L  AA  G      +L+    A +   DK   TPLH A  KG  +   L+L
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKY-NACVNATDKWAFTPLHEAAQKGRTQLCALLL 765

Query: 902 DKIQDESLINEK 913
               D +L N++
Sbjct: 766 AHGADPTLKNQE 777



 Score =  183 bits (465), Expect = 6e-46
 Identities = 173/589 (29%), Positives = 250/589 (42%), Gaps = 103/589 (17%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    DV+  D     PLH A   G  E+ ELL+  GA VNA D    TPLH A +  
Sbjct: 229 LLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKN 288

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVA----------------AANKAVKCAEV--II 102
             E   +L+ + AD    + + ++ + +A                +  +A + A+V  I 
Sbjct: 289 RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIK 348

Query: 103 PLLSSVNVS---DRGGRTALHHAALNGH---VEMVNLLLAKGANINAFDKKDRRALHWAA 156
             LS   V+    +   TALH AA + +    ++  LLL KGANIN   K+    LH A+
Sbjct: 349 KHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVAS 408

Query: 157 YMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
              H DVV +++ H A+V   D  G T LH AA  G +   + LL+ G + + I++ G T
Sbjct: 409 EKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT 468

Query: 217 ALHIACYNGQDAVVNELIDYG----------------------------ANVNQPNNNGF 248
           AL +   N Q  ++ E I  G                             N         
Sbjct: 469 ALQMGNENVQQ-LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS 527

Query: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
           TPLHFAA     ++ +E L+ +GADV+ + K G  PLH    +G +  ++ L+++G  ++
Sbjct: 528 TPLHFAAGYNRVSV-VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586

Query: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL--------------- 353
             D    TPLH AA  G   +   L   GAD  K       PL L               
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGD 646

Query: 354 -AALNAHSDCCR---KLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGADFH 407
            A L+A    C    K LSS   ++  D  GR  T LH AA   N+E  + L   GAD +
Sbjct: 647 AALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
            +DK G  PLH AA+  H      L+   A VN TD W  T LH AA             
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA------------- 753

Query: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
                          +K  T     LL + A+P+++++EG   +   +A
Sbjct: 754 ---------------QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787



 Score =  143 bits (360), Expect = 8e-34
 Identities = 173/615 (28%), Positives = 246/615 (40%), Gaps = 59/615 (9%)

Query: 329 LINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAA 388
           L+   + +  DTA        PLH AA     D    LL +G  +   D  G   LH A 
Sbjct: 43  LVTPEKVNSRDTAG---RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC 99

Query: 389 AGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448
           + G+ E + LL   GAD + +D    TPLH AA          L+  GA     +  GRT
Sbjct: 100 SFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159

Query: 449 ALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGY 508
           AL  A  S     K +L   +   E LE AR   E++    L  L   + N    D    
Sbjct: 160 ALDLADPSA----KAVLTGEYKKDELLESARSGNEEKMMALLTPL---NVNCHASDGRKS 212

Query: 509 NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
             +H AA Y   + ++LLL+   +     D G    PLH A   GH++  E+L++    +
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQH-GADVHAKDKGDLV-PLHNACSYGHYEVTELLVKHGACV 270

Query: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR------TPLH----ASVI 618
           +  D    T L  AA K   E    L++ GA   + +   K       TP      A   
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330

Query: 619 NGHTLCLRLLLEIADNPEAVDVKDAKG------------QTPLMLAVAYGHI---DAVSL 663
            GH+L     L+ A   +   +K                +T L  A A  +        L
Sbjct: 331 KGHSL-----LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICEL 385

Query: 664 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
           LL K AN++       T LH      H + V+++++ E  +   D+ G+T LH AA  GH
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445

Query: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPL 783
                 LL              QG+T L      GNEN  ++L E       +GN     
Sbjct: 446 LQTCRLLLSYGCDPNIISL---QGFTALQM----GNENVQQLLQEGIS----LGNSEADR 494

Query: 784 HCAIINDHGNCASLL-LGAIDSSIVSCRDDKGR--TPLRAAAFADHVECLQLLLRHSAPV 840
                   G+  ++  L  + S  V+CRD +GR  TPL  AA  + V  ++ LL+H A V
Sbjct: 495 QLLEAAKAGDVETVKKLCTVQS--VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

Query: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
           +A D  G   L  A   G     ++LV    A + V D    TPLH A +KG  +   L+
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHG-AVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 901 LDKIQDESLINEKNN 915
           L    D +  N   N
Sbjct: 612 LQHGADPTKKNRDGN 626



 Score =  119 bits (297), Expect = 2e-26
 Identities = 98/298 (32%), Positives = 134/298 (44%), Gaps = 43/298 (14%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+    DV+  D     PLH A   G  E+ ELL+  GA VN  D    TPLH A A   
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHV----------------AAANKAVKCAEVIIPLL 105
            E  ++L++H AD   ++++  TPL +                A  + A K     +  L
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664

Query: 106 SS---VNVSDRGGR--TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGH 160
           SS   VN  D  GR  T LH AA   ++E+   LL  GA++NA DK     LH AA  GH
Sbjct: 665 SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724

Query: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
           +DV ALLI + A V   DK  +TPLH AA  G+  +   LL  G +    N  G T L +
Sbjct: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784

Query: 221 --------------------ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
                               +CY  Q  V+N +   GA  +  ++   +P   +AAS+
Sbjct: 785 VSADDVSALLTAAMPPSALPSCYKPQ--VLNGVRSPGATADALSSGPSSPSSLSAASS 840



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 85/286 (29%), Positives = 120/286 (41%), Gaps = 23/286 (8%)

Query: 635 PEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
           PE V+ +D  G+  TPL  A  +G  D V  LL+  ANV   D  G   LH     GH E
Sbjct: 46  PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105

Query: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
            V +LL        +D+   TPLH AA +G       LLQ          ++  G T L 
Sbjct: 106 VVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPT---IRNTDGRTALD 162

Query: 753 WACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDD 812
            A    + +   VL  +    + + +  +          GN    ++  +    V+C   
Sbjct: 163 LA----DPSAKAVLTGEYKKDELLESARS----------GN-EEKMMALLTPLNVNCHAS 207

Query: 813 KGR--TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
            GR  TPL  AA  + V+ +QLLL+H A V+A D      L  A   G     ++LV   
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267

Query: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNA 916
            A +   D    TPLH A SK   +   L+L    D +L+N  N +
Sbjct: 268 -ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKS 312


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  237 bits (605), Expect = 3e-62
 Identities = 226/727 (31%), Positives = 323/727 (44%), Gaps = 90/727 (12%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+    +V+  D     PLH A   G AE++ LL+  GA  NA+DN   TPLH A     
Sbjct: 235 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 294

Query: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAAN-KAVKCAEV----------------IIPL 104
            +   VL++H AD N R+ + ++ L +A  + KAV   E                 ++ L
Sbjct: 295 IDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 354

Query: 105 LSSVNV----SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGH 160
           L+ +NV    SD    T LH AA    V +V LLL  GA+++A DK     LH A   GH
Sbjct: 355 LTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414

Query: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
            +V  LL+ HGA V   D   +TPLH AAS  ++ V   LL+ G +   +N +G +A+ +
Sbjct: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474

Query: 221 AC-----------YNGQD-----------AVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
           A            + G              V   L     N  QP ++  T LH A AS 
Sbjct: 475 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE-TALHCAVASL 533

Query: 259 H--GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 316
           H       ELL+  GA+VN ++KD  +PLH+ A        + L ++G +++ +D  G T
Sbjct: 534 HPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQT 593

Query: 317 PLHVAARYGHELLINTLRTSGAD----------TAKCG-------IHSMFPLH------- 352
            LH AA  GH      L + G+D           A+ G       +    P+        
Sbjct: 594 ALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYR 653

Query: 353 -LAALNAHSDCCRKLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGADFHKK 409
            L A  A      K L S   ++  D  GR  T LH AA    V  ++ L   GAD H K
Sbjct: 654 LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK 713

Query: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA-SDMDRNKTILGNA 468
           DK G  PLH A +  H+   E LV  GA+VN  D W  T LH AAA    +  K +L + 
Sbjct: 714 DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG 773

Query: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAYGHRQCLELLL 527
            D ++        K ++    L+ + + D +  I+D   G  ++  AA  G    ++ L 
Sbjct: 774 ADPTK--------KNRDGNTPLDLVKEGDTD--IQDLLRGDAALLDAAKKGCLARVQKLC 823

Query: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587
              N    ++  G   +PLHLAA   + +  E LL+   D++ +D+ G   L  AA  GH
Sbjct: 824 TPENINCRDT-QGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882

Query: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
            +    LI     +   D     TPLH +   G T    LLL    +P    +K+ +GQT
Sbjct: 883 VDIAALLIKYNTCVNATDK-WAFTPLHEAAQKGRTQLCALLLAHGADP---TMKNQEGQT 938

Query: 648 PLMLAVA 654
           PL LA A
Sbjct: 939 PLDLATA 945



 Score =  220 bits (561), Expect = 4e-57
 Identities = 228/791 (28%), Positives = 347/791 (43%), Gaps = 75/791 (9%)

Query: 72  SADVNARDKNWQ--TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
           +A+VNA+D   +  +PLH AA        E ++ + ++V+  D GG   LH+A   GH E
Sbjct: 204 AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAE 263

Query: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
           +V+LLL +GA+ NA D  +   LH AA  G +DV  +L+ HGA+   ++  G + L  A 
Sbjct: 264 VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323

Query: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
            +      K +L    + DE+       L  A    ++ ++  L     N +  +    T
Sbjct: 324 PS-----AKAVLTGEYKKDEL-------LEAARSGNEEKLMALLTPLNVNCHASDGRKST 371

Query: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 309
           PLH AA      + ++LL+ +GADV+ + K G  PLH    +G +  ++ L+++G  ++ 
Sbjct: 372 PLHLAAGYNRVRI-VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430

Query: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA-----------ALNA 358
           +D    TPLH AA      + + L + GAD      H    + +A               
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490

Query: 359 HS--------DCCRKLLSSGFEIDT--PDKFGRTCLHAAAAG---GNVECIKLLQSSGAD 405
           HS        D  +   +   EI      +   T LH A A       +  +LL   GA+
Sbjct: 491 HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550

Query: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTI 464
            ++K+K   TPLH AA   H   +E L   GA +N  D  G+TALH AA A  +   + +
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
           L    D S    +     +       + L  +++ P IR  +    +  A+  G  + ++
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQIL--SESTP-IRTSDVDYRLLEASKAGDLETVK 667

Query: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
            L    N    + + G   +PLH AA       +E LL    D+  +D+ G   L  A  
Sbjct: 668 QLCSSQNVNCRDLE-GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726

Query: 585 KGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
            GH E  E L+  GAS+ V D + K TPLH +   G     +LLL+   +P     K+  
Sbjct: 727 YGHYEVAELLVRHGASVNVAD-LWKFTPLHEAAAKGKYEICKLLLKHGADPTK---KNRD 782

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL-GCTALHRGIMTGHEECVQMLLEQEVS 703
           G TPL L               KE + D  D+L G  AL      G    VQ L   E +
Sbjct: 783 GNTPLDLV--------------KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE-N 827

Query: 704 ILCKDSRGR--TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
           I C+D++GR  TPLH AA   +      LL+      D   +D  G  PLH A   G+ +
Sbjct: 828 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG---ADVNAQDKGGLIPLHNAASYGHVD 884

Query: 762 CIEVLLE-QKCFRKFIGNPFTPLHCAIINDHGN-CASLLLGAIDSSIVSCRDDKGRTPLR 819
              +L++   C        FTPLH A        CA LL    D ++   ++ +G+TPL 
Sbjct: 885 IAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM---KNQEGQTPLD 941

Query: 820 AAAFADHVECL 830
            A  AD +  L
Sbjct: 942 LAT-ADDIRAL 951



 Score =  210 bits (535), Expect = 4e-54
 Identities = 221/792 (27%), Positives = 334/792 (42%), Gaps = 111/792 (14%)

Query: 188 AASNGQINVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
           A  NG ++ VK L++   V   ++    ++ LH A   G+  VV  L+  GANV+  ++ 
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248

Query: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306
           G  PLH A +  H  + + LL+  GAD N +     +PLH  A+ G+      L+Q+G +
Sbjct: 249 GLIPLHNACSFGHAEV-VSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGA-DTAKCGIHSMFPLHLAALNA--HSDCC 363
            +  + DG + L +A      +L    +     + A+ G        L  LN   H+   
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367

Query: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423
           RK                T LH AA    V  ++LL   GAD H KDK G  PLH A + 
Sbjct: 368 RK---------------STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412

Query: 424 CHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL---------GNAHDNSEE 474
            H+   E L+  GA VN  D W  T LH AA+ +     ++L          N H  S  
Sbjct: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472

Query: 475 ---------------------LERARE--LKEKEATLCLEFLLQNDANPSIRDKEGYNSI 511
                                L+ ARE  L + + TL LE +  N   P   +     ++
Sbjct: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII--NFKQPQSHE----TAL 526

Query: 512 HYAAAYGH---RQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
           H A A  H   +Q  ELLL +  +  E++    T  PLH+AA   H+  +EVL +    +
Sbjct: 527 HCAVASLHPKRKQVTELLLRKGANVNEKNKDFMT--PLHVAAERAHNDVMEVLHKHGAKM 584

Query: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGA--SIF--------------VKDNVTKRTP 612
           +  D  G+TAL  AA  GH +    L++ G+  SI               V+  +++ TP
Sbjct: 585 NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTP 644

Query: 613 LHASVINGHTL------CLRLLLEIADNPEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLL 664
           +  S ++   L       L  + ++  + + V+ +D +G+  TPL  A  Y  +  V  L
Sbjct: 645 IRTSDVDYRLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 665 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHA 724
           L   A+V   D  G   LH     GH E  ++L+    S+   D    TPLH AAA+G  
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763

Query: 725 TWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLH 784
                LL+      D   K+  G TPL        +  I+ LL                 
Sbjct: 764 EICKLLLKHGA---DPTKKNRDGNTPLDLV--KEGDTDIQDLLRGDA------------- 805

Query: 785 CAIIND-HGNCASLLLGAIDSSIVSCRDDKGR--TPLRAAAFADHVECLQLLLRHSAPVN 841
            A+++     C + +        ++CRD +GR  TPL  AA  +++E  + LL H A VN
Sbjct: 806 -ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864

Query: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
           A D  G   L  AA  G      +L+      +   DK   TPLH A  KG  +   L+L
Sbjct: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTC-VNATDKWAFTPLHEAAQKGRTQLCALLL 923

Query: 902 DKIQDESLINEK 913
               D ++ N++
Sbjct: 924 AHGADPTMKNQE 935



 Score =  182 bits (463), Expect = 1e-45
 Identities = 176/592 (29%), Positives = 247/592 (41%), Gaps = 109/592 (18%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    DV+  D     PLH A   G  E+ ELL+  GA VNA D    TPLH A +  
Sbjct: 387 LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKN 446

Query: 61  SEEAVQVLIKHSAD---VNARDKN---------------WQTPLH--VAAANKAVKCAEV 100
             E   +L+ H AD   VN   K+               ++   H  + AA +A      
Sbjct: 447 RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 506

Query: 101 IIPLLSSVNVSD-RGGRTALHHAALNGH---VEMVNLLLAKGANINAFDKKDRRALHWAA 156
               L  +N    +   TALH A  + H    ++  LLL KGAN+N  +K     LH AA
Sbjct: 507 KTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566

Query: 157 YMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
              H DV+ +L  HGA++   D  G T LH AA  G +   + LL+ G +   I++ G T
Sbjct: 567 ERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT 626

Query: 217 ALHIACYNGQDAVVNEL----------IDY-------------------GANVNQPNNNG 247
           A  +    G +AV   L          +DY                     NVN  +  G
Sbjct: 627 AAQM----GNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEG 682

Query: 248 --FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGG 305
              TPLHFAA     ++ +E L+++GADV+ + K G  PLH    +G +  ++ L+++G 
Sbjct: 683 RHSTPLHFAAGYNRVSV-VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 741

Query: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL------------ 353
            ++  D    TPLH AA  G   +   L   GAD  K       PL L            
Sbjct: 742 SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL 801

Query: 354 ----AALNAHSDCCR---KLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGA 404
               A L+A    C    + L +   I+  D  GR  T LH AA   N+E  + L   GA
Sbjct: 802 RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 861

Query: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464
           D + +DK G  PLH AA+  H      L+     VN TD W  T LH AA          
Sbjct: 862 DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAA---------- 911

Query: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
                             +K  T     LL + A+P+++++EG   +  A A
Sbjct: 912 ------------------QKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score =  169 bits (429), Expect = 8e-42
 Identities = 138/427 (32%), Positives = 204/427 (47%), Gaps = 58/427 (13%)

Query: 51  TPLHRAVAS---RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS 107
           T LH AVAS   + ++  ++L++  A+VN ++K++ TPLHVAA        EV+    + 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKK-------------------- 147
           +N  D  G+TALH AAL GH++   LLL+ G++ +    +                    
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643

Query: 148 -------DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG--YTPLHAAASNGQINVVK 198
                  D R L  A+  G L+ V  L +    V C+D +G   TPLH AA   +++VV+
Sbjct: 644 PIRTSDVDYRLLE-ASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701

Query: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
           +LL+ G ++   +  G   LH AC  G   V   L+ +GA+VN  +   FTPLH AAA  
Sbjct: 702 YLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKG 761

Query: 259 HGALCLELLVNNGADVNIQSKDGKSPLHM--------------------TAVHGRFTRSQ 298
              +C +LL+ +GAD   +++DG +PL +                     A  G   R Q
Sbjct: 762 KYEIC-KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQ 820

Query: 299 TLIQNGGEIDCVDKDG--NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
            L      I+C D  G  +TPLH+AA Y +  +   L   GAD        + PLH AA 
Sbjct: 821 KLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAAS 879

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H D    L+     ++  DK+  T LH AA  G  +   LL + GAD   K++ G+TP
Sbjct: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939

Query: 417 LHYAAAN 423
           L  A A+
Sbjct: 940 LDLATAD 946



 Score =  127 bits (318), Expect = 6e-29
 Identities = 90/286 (31%), Positives = 135/286 (47%), Gaps = 25/286 (8%)

Query: 6   TEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
           +++VN  D E R  TPLH AA      ++E L+  GA V+AKD   L PLH A +    E
Sbjct: 672 SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 731

Query: 64  AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
             ++L++H A VN  D    TPLH AAA    +  ++++   +     +R G T L    
Sbjct: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD-LV 790

Query: 124 LNGHVEMVNLLLAKGA--------------------NINAFDKKDRRA--LHWAAYMGHL 161
             G  ++ +LL    A                    NIN  D + R +  LH AA   +L
Sbjct: 791 KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNL 850

Query: 162 DVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
           +V   L+ HGA+V  +DK G  PLH AAS G +++   L+     ++  + +  T LH A
Sbjct: 851 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 910

Query: 222 CYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
              G+  +   L+ +GA+    N  G TPL  A A    AL ++ +
Sbjct: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM 956



 Score =  112 bits (280), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 107/244 (43%), Gaps = 54/244 (22%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+H   DV+  D     PLH A   G  E+ ELL+  GA VN  D    TPLH A A   
Sbjct: 703 LLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGK 762

Query: 62  EEAVQVLIKHSAD----------------------------------------------- 74
            E  ++L+KH AD                                               
Sbjct: 763 YEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKL 822

Query: 75  -----VNARDKNWQ--TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
                +N RD   +  TPLH+AA    ++ AE ++   + VN  D+GG   LH+AA  GH
Sbjct: 823 CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882

Query: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
           V++  LL+     +NA DK     LH AA  G   + ALL+ HGA+ T K+++G TPL  
Sbjct: 883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942

Query: 188 AASN 191
           A ++
Sbjct: 943 ATAD 946


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  215 bits (547), Expect = 2e-55
 Identities = 174/576 (30%), Positives = 270/576 (46%), Gaps = 52/576 (9%)

Query: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
           +H AA +        L+V N A  + + + G++PL    +  R   +  L++ G +++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS-- 368
           D    T LH+AA+ G+   +  L T  A+  +  +  M PLHL   +    C   LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA------A 422
           +  E+DT DK  +T LH +A   N E +KLL    ++    D  G+ PLH+AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
                CI     T + +N  D  GRT LH+A A   D N T++                 
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA---DGNVTVVD---------------- 238

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS-GA 541
                           N +  D      +H+AA  GH Q + LLLER  SG   SDS GA
Sbjct: 239 --------VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
           T  PLH AA +   + ++V L+     D  D +GRT+   AA KG  + +  +++  + I
Sbjct: 291 T--PLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348

Query: 602 FVKDNVTKR---TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHI 658
            +  N+  +   T LHA+ ++GH   ++LLLE   N   VD  D    TPL  A   GH 
Sbjct: 349 DI--NMADKYGGTALHAAALSGHVSTVKLLLE---NNAQVDATDVMKHTPLFRACEMGHK 403

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
           D +  L++  A VD VD  G + LH   + G+ +  Q+L+E +++   +D  GRTPL  A
Sbjct: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
           A  G+   ++ L++   +  D   +D +G T LHW+C NG  + I++LL+   F   + N
Sbjct: 464 AYGGYINCMAVLME---NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN 520

Query: 779 ---PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
               +TPL  A++ +       +L     SI + +D
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  189 bits (481), Expect = 8e-48
 Identities = 154/499 (30%), Positives = 225/499 (45%), Gaps = 81/499 (16%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+    DVN  D  +RT LH+AA  G+   ++LL+   A    KD   +TPLH     RS
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126

Query: 62  EEAVQVLIKHSA--DVNARDKNWQT---------------------------------PL 86
            + + +L+K  A  +V+ +DKN QT                                 PL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186

Query: 87  HVAAANK------AVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA-KGA 139
           H AA +K       V+C     P  S +N  D  GRT LH A  +G+V +V++L + +  
Sbjct: 187 HWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246

Query: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC-KDKKGYTPLHAAASNGQINVVK 198
           NI ++D   R  LHWAA +GH  +V LL+      T   D +G TPLH AA +     VK
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA--NVNQPNNNGFTPLHFAAA 256
             L      D+ ++ G T+   A   G D V+  ++   +  ++N  +  G T LH AA 
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366

Query: 257 STHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 316
           S H    ++LL+ N A V+       +PL      G     QTLI+ G  +D VD+DG  
Sbjct: 367 SGH-VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG-- 423

Query: 317 PLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTP 376
                                        HS+  LH AAL  ++D C+ L+ +    +  
Sbjct: 424 -----------------------------HSL--LHWAALGGNADVCQILIENKINPNVQ 452

Query: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
           D  GRT L  AA GG + C+ +L  + AD + +DK GRT LH++  N +   I+ L+   
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 437 A--NVNETDDWGRTALHYA 453
           A  N  E ++   T L YA
Sbjct: 513 AFPNQMENNEERYTPLDYA 531



 Score =  179 bits (453), Expect = 1e-44
 Identities = 142/484 (29%), Positives = 230/484 (47%), Gaps = 27/484 (5%)

Query: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
           D   RTPL         +  + L+ +GA VN  D+   T LH A    +   +++L+   
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS--SVNVSDRGGRTALHHAALNGHVEM 130
           A+   +D    TPLH+   +++ KC  +++  ++   V+  D+  +TALH +A   + E 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL----LINHGAE----VTCKDKKGY 182
           V LL+   +NI   D + +  LHWAA   H D  A+     I   A     +  +D +G 
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222

Query: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGN---TALHIACYNGQDAVVNELIDYGAN 239
           TPLH A ++G + VV  L +   E   I  Y N   T LH A   G   +V+ L++   +
Sbjct: 223 TPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280

Query: 240 VNQPNNN-GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
              P+++ G TPLH+AA S   A  +++ + + +  +    +G++     A  G     +
Sbjct: 281 GTIPSDSQGATPLHYAAQSNF-AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339

Query: 299 TLIQNGGEIDC--VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
           T++    +ID    DK G T LH AA  GH   +  L  + A      +    PL  A  
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H D  + L+  G  +D  D+ G + LH AA GGN +  ++L  +  + + +D  GRTP
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTILG-----NAHD 470
           L  AA   + +C+  L+   A+ N  D  GRTALH++  +  +D  K +L      N  +
Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519

Query: 471 NSEE 474
           N+EE
Sbjct: 520 NNEE 523



 Score =  173 bits (439), Expect = 6e-43
 Identities = 151/556 (27%), Positives = 245/556 (44%), Gaps = 93/556 (16%)

Query: 384 LHAAAAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNET 442
           +HAAA  G+   + +L+  + A   K+D+ GRTPL Y        C + L+  GA+VN+T
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 443 DDWGRTALHYAAASDMDRNKTILGNAHDN-----SEELERARELKEKEATLCLEFLLQND 497
           D   RTALH AA     R   +L     N      EE+          +  CL  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 498 ANPSI--RDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGH 554
           A   +  +DK    ++H++A Y + + ++LL++  +N G  + +    K PLH AA +  
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG---KIPLHWAANHKD 194

Query: 555 HQALEVLLQSLVD-------LDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDN 606
             A+  + + ++D       L+ +D +GRT L  A   G+   V+ L +    +I   DN
Sbjct: 195 PSAVHTV-RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253

Query: 607 VTKRTPLHASVINGHTLCLRLLLE-------------------------------IADNP 635
           +  RTPLH + + GH   + LLLE                                  +P
Sbjct: 254 LF-RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312

Query: 636 EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT--VDILGCTALHRGIMTGHEEC 693
              D  D +G+T  M A   G  D +  +L  ++++D    D  G TALH   ++GH   
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372

Query: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753
           V++LLE    +   D    TPL  A   GH   +  L++     +     D  G++ LHW
Sbjct: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD---LVDQDGHSLLHW 429

Query: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
           A   GN +  ++L+E K       NP                            + +D  
Sbjct: 430 AALGGNADVCQILIENKI------NP----------------------------NVQDYA 455

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQA 872
           GRTPL+ AA+  ++ C+ +L+ ++A  N  D  G+TAL  +  NG   A+ +L++ +A  
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 873 DLTVKDKDLNTPLHLA 888
           +    +++  TPL  A
Sbjct: 516 NQMENNEERYTPLDYA 531



 Score =  155 bits (392), Expect = 2e-37
 Identities = 141/509 (27%), Positives = 240/509 (47%), Gaps = 58/509 (11%)

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDD-WGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
           +H AA N     ++ L+   + + + +D +GRT L Y   +D                 L
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLAD----------------RL 61

Query: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535
           +            C + LL+  A+ +  D     ++H AA  G+ + ++LLL R  +  +
Sbjct: 62  D------------CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLV--DLDIRDEKGRTALDLAAFKGHTECVEA 593
           +     T  PLHL   +   + L +LL+ +   ++D +D+  +TAL  +A+  + E V+ 
Sbjct: 110 KDLEEMT--PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 594 LINPGASIFVKDNVTKRTPLHASVING-----HTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           LI   ++I + D V  + PLH +  +      HT+  R +L+ A     ++ +D +G+TP
Sbjct: 168 LIKHDSNIGIPD-VEGKIPLHWAANHKDPSAVHTV--RCILDAAPTESLLNWQDYEGRTP 224

Query: 649 LMLAVAYGHIDAVSLLLEKEA-NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS-ILC 706
           L  AVA G++  V +L   E+ N+ + D L  T LH   + GH + V +LLE+  S  + 
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
            DS+G TPLHYAA    A  +   L+    ++D    D +G T   WA   G+++ +  +
Sbjct: 285 SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD---SDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 767 LEQKC------FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
           L  K         K+ G   T LH A ++ H +   LLL   +++ V   D    TPL  
Sbjct: 342 LSLKSDIDINMADKYGG---TALHAAALSGHVSTVKLLLE--NNAQVDATDVMKHTPLFR 396

Query: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKD 880
           A    H + +Q L++  A V+ VD  G + L  AA  G A    IL+ + + +  V+D  
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQDYA 455

Query: 881 LNTPLHLACSKGHEKCALLILDKIQDESL 909
             TPL  A   G+  C  ++++   D ++
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNI 484



 Score =  140 bits (352), Expect = 7e-33
 Identities = 124/424 (29%), Positives = 195/424 (45%), Gaps = 28/424 (6%)

Query: 509 NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
           + +H AA  G +  L+ L+   NS  ++ +    ++PL            + LL++  D+
Sbjct: 16  SQVHAAAVNGDKGALQRLIVG-NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
           +  D   RTAL LAA KG+   ++ L+   A+   KD + + TPLH +  +    CL LL
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-LEEMTPLHLTTRHRSPKCLALL 133

Query: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
           L+    P  VD +D   QT L  +  Y + + V LL++ ++N+   D+ G   LH     
Sbjct: 134 LKFMA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA--A 190

Query: 689 GHEE--------CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
            H++        C+      E  +  +D  GRTPLH+A A G+ T    ++ +  S E C
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT----VVDVLTSYESC 246

Query: 741 CFK--DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCAS 796
                DN   TPLHWA   G+   + +LLE+        +    TPLH A  ++      
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 797 LLLGAIDSSIVSCRDDKGRTPLRAAAF--ADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854
           + L     S+    D +GRT    AA   +D V    L L+    +N  D  G TAL  A
Sbjct: 307 VFLK--HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAA 364

Query: 855 AENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           A +G    V +L+ N+AQ D T  D   +TPL  AC  GH+     ++       L+++ 
Sbjct: 365 ALSGHVSTVKLLLENNAQVDAT--DVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 914 NNAL 917
            ++L
Sbjct: 423 GHSL 426



 Score =  127 bits (320), Expect = 4e-29
 Identities = 94/303 (31%), Positives = 141/303 (46%), Gaps = 39/303 (12%)

Query: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLI-LSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
           ++ + D+  RTPLH AA LG A+I+ LL+  + +     D+   TPLH A  S   E V+
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 67  VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV--NVSDRGGRTALHHAAL 124
           V +KH +  +  D   +T    AA   +      ++ L S +  N++D+ G TALH AAL
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366

Query: 125 NGHVEMVNLLLAK---------------------------------GANINAFDKKDRRA 151
           +GHV  V LLL                                   GA ++  D+     
Sbjct: 367 SGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL 426

Query: 152 LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211
           LHWAA  G+ DV  +LI +      +D  G TPL  AA  G IN +  L+    + +  +
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486

Query: 212 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGALCLELLVN 269
             G TALH +C NG    +  L+D+ A  NQ  NN   +TPL +A       + ++ ++ 
Sbjct: 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV-IQFMLE 545

Query: 270 NGA 272
           +GA
Sbjct: 546 HGA 548



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 54/174 (31%), Positives = 89/174 (51%), Gaps = 2/174 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+     V+  D  K TPL  A  +G  ++I+ LI  GARV+  D    + LH A    
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           + +  Q+LI++  + N +D   +TPL  AA    + C  V++   +  N+ D+ GRTALH
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGA 172
            +  NG+++ + LLL   A  N  +  + R   L +A      +V+  ++ HGA
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  215 bits (547), Expect = 2e-55
 Identities = 174/576 (30%), Positives = 270/576 (46%), Gaps = 52/576 (9%)

Query: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
           +H AA +        L+V N A  + + + G++PL    +  R   +  L++ G +++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS-- 368
           D    T LH+AA+ G+   +  L T  A+  +  +  M PLHL   +    C   LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA------A 422
           +  E+DT DK  +T LH +A   N E +KLL    ++    D  G+ PLH+AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
                CI     T + +N  D  GRT LH+A A   D N T++                 
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA---DGNVTVVD---------------- 238

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS-GA 541
                           N +  D      +H+AA  GH Q + LLLER  SG   SDS GA
Sbjct: 239 --------VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
           T  PLH AA +   + ++V L+     D  D +GRT+   AA KG  + +  +++  + I
Sbjct: 291 T--PLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348

Query: 602 FVKDNVTKR---TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHI 658
            +  N+  +   T LHA+ ++GH   ++LLLE   N   VD  D    TPL  A   GH 
Sbjct: 349 DI--NMADKYGGTALHAAALSGHVSTVKLLLE---NNAQVDATDVMKHTPLFRACEMGHK 403

Query: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
           D +  L++  A VD VD  G + LH   + G+ +  Q+L+E +++   +D  GRTPL  A
Sbjct: 404 DVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
           A  G+   ++ L++   +  D   +D +G T LHW+C NG  + I++LL+   F   + N
Sbjct: 464 AYGGYINCMAVLME---NNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN 520

Query: 779 ---PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
               +TPL  A++ +       +L     SI + +D
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  189 bits (481), Expect = 8e-48
 Identities = 154/499 (30%), Positives = 225/499 (45%), Gaps = 81/499 (16%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
           L+    DVN  D  +RT LH+AA  G+   ++LL+   A    KD   +TPLH     RS
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126

Query: 62  EEAVQVLIKHSA--DVNARDKNWQT---------------------------------PL 86
            + + +L+K  A  +V+ +DKN QT                                 PL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186

Query: 87  HVAAANK------AVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA-KGA 139
           H AA +K       V+C     P  S +N  D  GRT LH A  +G+V +V++L + +  
Sbjct: 187 HWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246

Query: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC-KDKKGYTPLHAAASNGQINVVK 198
           NI ++D   R  LHWAA +GH  +V LL+      T   D +G TPLH AA +     VK
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA--NVNQPNNNGFTPLHFAAA 256
             L      D+ ++ G T+   A   G D V+  ++   +  ++N  +  G T LH AA 
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366

Query: 257 STHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 316
           S H    ++LL+ N A V+       +PL      G     QTLI+ G  +D VD+DG  
Sbjct: 367 SGH-VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG-- 423

Query: 317 PLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTP 376
                                        HS+  LH AAL  ++D C+ L+ +    +  
Sbjct: 424 -----------------------------HSL--LHWAALGGNADVCQILIENKINPNVQ 452

Query: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
           D  GRT L  AA GG + C+ +L  + AD + +DK GRT LH++  N +   I+ L+   
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 437 A--NVNETDDWGRTALHYA 453
           A  N  E ++   T L YA
Sbjct: 513 AFPNQMENNEERYTPLDYA 531



 Score =  179 bits (453), Expect = 1e-44
 Identities = 142/484 (29%), Positives = 230/484 (47%), Gaps = 27/484 (5%)

Query: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
           D   RTPL         +  + L+ +GA VN  D+   T LH A    +   +++L+   
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS--SVNVSDRGGRTALHHAALNGHVEM 130
           A+   +D    TPLH+   +++ KC  +++  ++   V+  D+  +TALH +A   + E 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL----LINHGAE----VTCKDKKGY 182
           V LL+   +NI   D + +  LHWAA   H D  A+     I   A     +  +D +G 
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGR 222

Query: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGN---TALHIACYNGQDAVVNELIDYGAN 239
           TPLH A ++G + VV  L +   E   I  Y N   T LH A   G   +V+ L++   +
Sbjct: 223 TPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKS 280

Query: 240 VNQPNNN-GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
              P+++ G TPLH+AA S   A  +++ + + +  +    +G++     A  G     +
Sbjct: 281 GTIPSDSQGATPLHYAAQSNF-AETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339

Query: 299 TLIQNGGEIDC--VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
           T++    +ID    DK G T LH AA  GH   +  L  + A      +    PL  A  
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
             H D  + L+  G  +D  D+ G + LH AA GGN +  ++L  +  + + +D  GRTP
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTILG-----NAHD 470
           L  AA   + +C+  L+   A+ N  D  GRTALH++  +  +D  K +L      N  +
Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519

Query: 471 NSEE 474
           N+EE
Sbjct: 520 NNEE 523



 Score =  173 bits (439), Expect = 6e-43
 Identities = 151/556 (27%), Positives = 245/556 (44%), Gaps = 93/556 (16%)

Query: 384 LHAAAAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNET 442
           +HAAA  G+   + +L+  + A   K+D+ GRTPL Y        C + L+  GA+VN+T
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 443 DDWGRTALHYAAASDMDRNKTILGNAHDN-----SEELERARELKEKEATLCLEFLLQND 497
           D   RTALH AA     R   +L     N      EE+          +  CL  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 498 ANPSI--RDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGH 554
           A   +  +DK    ++H++A Y + + ++LL++  +N G  + +    K PLH AA +  
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG---KIPLHWAANHKD 194

Query: 555 HQALEVLLQSLVD-------LDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDN 606
             A+  + + ++D       L+ +D +GRT L  A   G+   V+ L +    +I   DN
Sbjct: 195 PSAVHTV-RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253

Query: 607 VTKRTPLHASVINGHTLCLRLLLE-------------------------------IADNP 635
           +  RTPLH + + GH   + LLLE                                  +P
Sbjct: 254 LF-RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312

Query: 636 EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT--VDILGCTALHRGIMTGHEEC 693
              D  D +G+T  M A   G  D +  +L  ++++D    D  G TALH   ++GH   
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVST 372

Query: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753
           V++LLE    +   D    TPL  A   GH   +  L++     +     D  G++ LHW
Sbjct: 373 VKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD---LVDQDGHSLLHW 429

Query: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
           A   GN +  ++L+E K       NP                            + +D  
Sbjct: 430 AALGGNADVCQILIENKI------NP----------------------------NVQDYA 455

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQA 872
           GRTPL+ AA+  ++ C+ +L+ ++A  N  D  G+TAL  +  NG   A+ +L++ +A  
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFP 515

Query: 873 DLTVKDKDLNTPLHLA 888
           +    +++  TPL  A
Sbjct: 516 NQMENNEERYTPLDYA 531



 Score =  155 bits (392), Expect = 2e-37
 Identities = 141/509 (27%), Positives = 240/509 (47%), Gaps = 58/509 (11%)

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDD-WGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
           +H AA N     ++ L+   + + + +D +GRT L Y   +D                 L
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLAD----------------RL 61

Query: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535
           +            C + LL+  A+ +  D     ++H AA  G+ + ++LLL R  +  +
Sbjct: 62  D------------CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLV--DLDIRDEKGRTALDLAAFKGHTECVEA 593
           +     T  PLHL   +   + L +LL+ +   ++D +D+  +TAL  +A+  + E V+ 
Sbjct: 110 KDLEEMT--PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 594 LINPGASIFVKDNVTKRTPLHASVING-----HTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           LI   ++I + D V  + PLH +  +      HT+  R +L+ A     ++ +D +G+TP
Sbjct: 168 LIKHDSNIGIPD-VEGKIPLHWAANHKDPSAVHTV--RCILDAAPTESLLNWQDYEGRTP 224

Query: 649 LMLAVAYGHIDAVSLLLEKEA-NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS-ILC 706
           L  AVA G++  V +L   E+ N+ + D L  T LH   + GH + V +LLE+  S  + 
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284

Query: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
            DS+G TPLHYAA    A  +   L+    ++D    D +G T   WA   G+++ +  +
Sbjct: 285 SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD---SDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 767 LEQKC------FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
           L  K         K+ G   T LH A ++ H +   LLL   +++ V   D    TPL  
Sbjct: 342 LSLKSDIDINMADKYGG---TALHAAALSGHVSTVKLLLE--NNAQVDATDVMKHTPLFR 396

Query: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKD 880
           A    H + +Q L++  A V+ VD  G + L  AA  G A    IL+ + + +  V+D  
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN-KINPNVQDYA 455

Query: 881 LNTPLHLACSKGHEKCALLILDKIQDESL 909
             TPL  A   G+  C  ++++   D ++
Sbjct: 456 GRTPLQCAAYGGYINCMAVLMENNADPNI 484



 Score =  140 bits (352), Expect = 7e-33
 Identities = 124/424 (29%), Positives = 195/424 (45%), Gaps = 28/424 (6%)

Query: 509 NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
           + +H AA  G +  L+ L+   NS  ++ +    ++PL            + LL++  D+
Sbjct: 16  SQVHAAAVNGDKGALQRLIVG-NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
           +  D   RTAL LAA KG+   ++ L+   A+   KD + + TPLH +  +    CL LL
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-LEEMTPLHLTTRHRSPKCLALL 133

Query: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
           L+    P  VD +D   QT L  +  Y + + V LL++ ++N+   D+ G   LH     
Sbjct: 134 LKFMA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA--A 190

Query: 689 GHEE--------CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
            H++        C+      E  +  +D  GRTPLH+A A G+ T    ++ +  S E C
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT----VVDVLTSYESC 246

Query: 741 CFK--DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCAS 796
                DN   TPLHWA   G+   + +LLE+        +    TPLH A  ++      
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 797 LLLGAIDSSIVSCRDDKGRTPLRAAAF--ADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854
           + L     S+    D +GRT    AA   +D V    L L+    +N  D  G TAL  A
Sbjct: 307 VFLK--HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAA 364

Query: 855 AENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           A +G    V +L+ N+AQ D T  D   +TPL  AC  GH+     ++       L+++ 
Sbjct: 365 ALSGHVSTVKLLLENNAQVDAT--DVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 914 NNAL 917
            ++L
Sbjct: 423 GHSL 426



 Score =  127 bits (320), Expect = 4e-29
 Identities = 94/303 (31%), Positives = 141/303 (46%), Gaps = 39/303 (12%)

Query: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLI-LSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
           ++ + D+  RTPLH AA LG A+I+ LL+  + +     D+   TPLH A  S   E V+
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306

Query: 67  VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV--NVSDRGGRTALHHAAL 124
           V +KH +  +  D   +T    AA   +      ++ L S +  N++D+ G TALH AAL
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366

Query: 125 NGHVEMVNLLLAK---------------------------------GANINAFDKKDRRA 151
           +GHV  V LLL                                   GA ++  D+     
Sbjct: 367 SGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL 426

Query: 152 LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211
           LHWAA  G+ DV  +LI +      +D  G TPL  AA  G IN +  L+    + +  +
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486

Query: 212 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGALCLELLVN 269
             G TALH +C NG    +  L+D+ A  NQ  NN   +TPL +A       + ++ ++ 
Sbjct: 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV-IQFMLE 545

Query: 270 NGA 272
           +GA
Sbjct: 546 HGA 548



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 54/174 (31%), Positives = 89/174 (51%), Gaps = 2/174 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+     V+  D  K TPL  A  +G  ++I+ LI  GARV+  D    + LH A    
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           + +  Q+LI++  + N +D   +TPL  AA    + C  V++   +  N+ D+ GRTALH
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGA 172
            +  NG+++ + LLL   A  N  +  + R   L +A      +V+  ++ HGA
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  185 bits (470), Expect = 1e-46
 Identities = 116/372 (31%), Positives = 182/372 (48%), Gaps = 1/372 (0%)

Query: 16  KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV 75
           K TPLH     G  E + LL+     V+ +     TPL  A   +  +   +L+ H AD 
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421

Query: 76  NARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL 135
           N  D++   PLH AA N     A +++   + V+  +R G T LH AA N    +  LL+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 136 AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195
           ++ A+ N  + + +  LH AAY GH+ +V LL + GAE+  + +   TPLH A   G++ 
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541

Query: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA 255
            ++HLL  G   D ++  G   LH A   G+  +   L+ YGA++  P + G+TPLH AA
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601

Query: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
              H  + + LL  + A++        +PLH+ A HG       L+Q G + +  ++ G 
Sbjct: 602 YKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375
           TPLH+A +    L +  L    A+          P HLAAL  ++   + L+ +G ++D 
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 376 PDKFGRTCLHAA 387
            D    T L  A
Sbjct: 721 QDGVSCTPLQLA 732



 Score =  174 bits (442), Expect = 3e-43
 Identities = 113/354 (31%), Positives = 176/354 (49%), Gaps = 2/354 (0%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L H+  DV+   +   TPL +AA     ++  LL+  GA  N  D     PLH A  + 
Sbjct: 381 LLAHEV-DVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
            +   ++L+ H A V+A+++   TPLH+AA N     A +++   +  N+ +  G+T LH
Sbjct: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLH 499

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA  GHV +V LL ++GA ++A  +  R  LH A   G +  +  L+  GA     D+ 
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           GY PLH AA+ G+  + K LL  G  ++     G T LH+A Y G   +++ L +  AN+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
                  +TPLH AA     A+ +  L+  GAD N   + G +PLH+      F     L
Sbjct: 620 GALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354
           +++   +   +K G TP H+AA  G+  ++  L  +GA        S  PL LA
Sbjct: 679 LEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732



 Score =  173 bits (438), Expect = 8e-43
 Identities = 123/407 (30%), Positives = 187/407 (45%), Gaps = 34/407 (8%)

Query: 50  LTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109
           +TPLH  VA  S E V++L+ H  DV+ +  +  TPL +AA ++                
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQ---------------- 406

Query: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
                              ++  LLLA GA+ N  D+     LH+AA  G      LL++
Sbjct: 407 -----------------QPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449

Query: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
           HGA V  ++++G+TPLH AA N   NV + L++   + +     G T LH+A Y G  ++
Sbjct: 450 HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509

Query: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA 289
           V  L   GA ++    N  TPLH  A        ++ L+ +GA  +   + G  PLH  A
Sbjct: 510 VKLLTSQGAELDAQQRNLRTPLHL-AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568

Query: 290 VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMF 349
             G++   + L++ G  ++     G TPLH+AA  GH  +I+ L  S A+    G  +  
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628

Query: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
           PLHLAA +        LL  G + +  ++ G T LH A        +  L    A+ H +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688

Query: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456
           +K G TP H AA   +   ++ LV  GA ++  D    T L  A  S
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735



 Score =  169 bits (427), Expect = 1e-41
 Identities = 106/344 (30%), Positives = 171/344 (49%), Gaps = 1/344 (0%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    D N +D +   PLH AA  GD     LL+  GA V+A++    TPLH A  + 
Sbjct: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN 472

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
            E   ++L+   AD N  +   +TPLHVAA    V   +++    + ++   R  RT LH
Sbjct: 473 FENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            A   G V  +  LL  GA  +A D+     LH AA  G   +  +L+ +GA +     +
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH AA  G + ++  L      +  +     T LH+A  +G++AVV+ L+  GA+ 
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N    +G+TPLH A   +     + LL ++ A+V+ ++K G +P H+ A+ G     + L
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHH-ANVHARNKVGWTPAHLAALKGNTAILKVL 711

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344
           ++ G ++D  D    TPL +A R   + +++ L       A  G
Sbjct: 712 VEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLG 755



 Score =  157 bits (397), Expect = 4e-38
 Identities = 125/410 (30%), Positives = 185/410 (45%), Gaps = 31/410 (7%)

Query: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232
           E  C  +   TPLH   + G +  V+ LL   V++D     G T L IA  + Q  +   
Sbjct: 354 EELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCAL 413

Query: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292
           L+ +GA+ N+ + +G+ PLHFAA +        LL+++GA V+ Q ++G +PLH+ A + 
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTA-RLLLDHGACVDAQEREGWTPLHLAAQNN 472

Query: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
               ++ L+    + +  + +G TPLHVAA +GH  L+  L + GA+      +   PLH
Sbjct: 473 FENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532

Query: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412
           LA         + LL SG   D  D+ G   LH AAA G     K+L   GA        
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592

Query: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNS 472
           G TPLH AA   H   I  L  + AN+        T LH AA                + 
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAAR---------------HG 637

Query: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
           EE               +  LLQ  A+P+  ++ G+  +H A        +  LLE   +
Sbjct: 638 EE-------------AVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684

Query: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
               +  G T  P HLAA  G+   L+VL+++   LD++D    T L LA
Sbjct: 685 VHARNKVGWT--PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732



 Score =  152 bits (383), Expect = 2e-36
 Identities = 130/430 (30%), Positives = 196/430 (45%), Gaps = 37/430 (8%)

Query: 246 NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGG 305
           N  TPLHF  A       + LL+ +  DV+ Q+  G +PL + A   +      L+ +G 
Sbjct: 361 NKVTPLHFLVAQG-SVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
           + + VD+DG  PLH AA+ G +     L   GA           PLHLAA N   +  R 
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
           L+S   + +  +  G+T LH AA  G+V  +KLL S GA+   + +  RTPLH A     
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
              I+ L+ +GA  +  D  G   LH AAA    R K ++                    
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAA----RGKYLI-------------------- 575

Query: 486 ATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE-RTNSGFEESDSGATKS 544
                + LL+  A+  +   +G+  +H AA  GH + + LL E   N G   +      +
Sbjct: 576 ----CKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG---ALGAVNWT 628

Query: 545 PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK 604
           PLHLAA +G    +  LLQ   D +  ++ G T L LA  +     V  L+   A++  +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688

Query: 605 DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
           + V   TP H + + G+T  L++L+E       +DV+D    TPL LA+       +S L
Sbjct: 689 NKVGW-TPAHLAALKGNTAILKVLVEAGAQ---LDVQDGVSCTPLQLALRSRKQGIMSFL 744

Query: 665 LEKEANVDTV 674
             KE +V T+
Sbjct: 745 EGKEPSVATL 754



 Score =  150 bits (380), Expect = 4e-36
 Identities = 125/418 (29%), Positives = 186/418 (44%), Gaps = 34/418 (8%)

Query: 202 NLGVEIDEINVYGN--TALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTH 259
           NL    +E+ +Y N  T LH     G    V  L+ +  +V+    +G+TPL  AA    
Sbjct: 348 NLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQ 407

Query: 260 GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319
             LC  LL+ +GAD N   +DG +PLH  A +G    ++ L+ +G  +D  +++G TPLH
Sbjct: 408 PDLCA-LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLH 466

Query: 320 VAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
           +AA+   E +   L +  AD          PLH+AA   H    + L S G E+D   + 
Sbjct: 467 LAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRN 526

Query: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
            RT LH A   G V  I+ L  SGA     D+ G  PLH AAA   +   + L+  GA++
Sbjct: 527 LRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586

Query: 440 NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDAN 499
                 G T LH AA                             K     +  L ++ AN
Sbjct: 587 ELPTHQGWTPLHLAA----------------------------YKGHLEIIHLLAESHAN 618

Query: 500 PSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALE 559
                   +  +H AA +G    +  LL+          SG T  PLHLA       ++ 
Sbjct: 619 MGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT--PLHLAVQRSTFLSVI 676

Query: 560 VLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617
            LL+   ++  R++ G T   LAA KG+T  ++ L+  GA + V+D V+  TPL  ++
Sbjct: 677 NLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS-CTPLQLAL 733



 Score =  146 bits (369), Expect = 8e-35
 Identities = 124/422 (29%), Positives = 181/422 (42%), Gaps = 34/422 (8%)

Query: 283 SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAK 342
           +PLH     G   + + L+ +  ++DC    G TPL +AA+     L   L   GAD  +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
                  PLH AA N      R LL  G  +D  ++ G T LH AA        +LL S 
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNK 462
            AD +  +  G+TPLH AA   H   ++ L + GA ++      RT LH A         
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV-------- 535

Query: 463 TILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQC 522
                               E+     ++ LL++ A P   D+ GY  +H AAA G    
Sbjct: 536 --------------------ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI 575

Query: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
            ++LL    S    +  G T  PLHLAAY GH + + +L +S  ++        T L LA
Sbjct: 576 CKMLLRYGASLELPTHQGWT--PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633

Query: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
           A  G    V AL+  GA     +  +  TPLH +V     L +  LLE   N   V  ++
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHAN---VHARN 689

Query: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
             G TP  LA   G+   + +L+E  A +D  D + CT L   + +  +  +  L  +E 
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEP 749

Query: 703 SI 704
           S+
Sbjct: 750 SV 751



 Score =  142 bits (358), Expect = 1e-33
 Identities = 89/284 (31%), Positives = 141/284 (49%), Gaps = 3/284 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +  D N  ++E +TPLHVAA+ G   +++LL   GA ++A+     TPLH AV   
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
              A+Q L+K  A  +A D++   PLH AAA       ++++   +S+ +    G T LH
Sbjct: 539 KVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLH 598

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            AA  GH+E+++LL    AN+ A    +   LH AA  G   VV+ L+  GA+    ++ 
Sbjct: 599 LAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G+TPLH A        V +LL     +   N  G T  H+A   G  A++  L++ GA +
Sbjct: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
           +  +    TPL  A  S    +   L    G + ++ +  G  P
Sbjct: 719 DVQDGVSCTPLQLALRSRKQGIMSFL---EGKEPSVATLGGSKP 759



 Score =  137 bits (344), Expect = 6e-32
 Identities = 111/388 (28%), Positives = 172/388 (44%), Gaps = 39/388 (10%)

Query: 382 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441
           T LH   A G+VE ++LL +   D   +   G TPL  AA +        L+  GA+ N 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 442 TDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 501
            D+ G   LH+AA            N  D +  L                 LL + A   
Sbjct: 424 VDEDGWAPLHFAAQ-----------NGDDGTARL-----------------LLDHGACVD 455

Query: 502 IRDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEV 560
            +++EG+  +H AA         LL+ R  +    E++    K+PLH+AAY GH   +++
Sbjct: 456 AQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG---KTPLHVAAYFGHVSLVKL 512

Query: 561 LLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVING 620
           L     +LD +    RT L LA  +G    ++ L+  GA     D  +   PLH +   G
Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ-SGYGPLHTAAARG 571

Query: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
             L  ++LL       ++++   +G TPL LA   GH++ + LL E  AN+  +  +  T
Sbjct: 572 KYLICKMLLRYG---ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628

Query: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
            LH     G E  V  LL+        +  G TPLH A  R  +T+LS ++ +     + 
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR--STFLS-VINLLEHHANV 685

Query: 741 CFKDNQGYTPLHWACYNGNENCIEVLLE 768
             ++  G+TP H A   GN   ++VL+E
Sbjct: 686 HARNKVGWTPAHLAALKGNTAILKVLVE 713



 Score =  133 bits (334), Expect = 9e-31
 Identities = 120/418 (28%), Positives = 182/418 (43%), Gaps = 39/418 (9%)

Query: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
           PLH        +  R LL+   ++D     G T L  AA     +   LL + GAD ++ 
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424

Query: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469
           D+ G  PLH+AA N        L+  GA V+  +  G T LH AA               
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA--------------Q 470

Query: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
           +N E + R               L+   A+P++ + EG   +H AA +GH   ++LL   
Sbjct: 471 NNFENVAR--------------LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL--- 513

Query: 530 TNSGFE-ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
           T+ G E ++     ++PLHLA   G  +A++ LL+S    D  D+ G   L  AA +G  
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573

Query: 589 ECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
              + L+  GAS+ +  +    TPLH +   GH   + LL E   N  A+    A   TP
Sbjct: 574 LICKMLLRYGASLELPTH-QGWTPLHLAAYKGHLEIIHLLAESHANMGALG---AVNWTP 629

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L LA  +G    VS LL+  A+ +  +  G T LH  +       V  LLE   ++  ++
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689

Query: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
             G TP H AA +G+   L  L++     +    +D    TPL  A  +  +  +  L
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLD---VQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  128 bits (321), Expect = 3e-29
 Identities = 126/420 (30%), Positives = 184/420 (43%), Gaps = 20/420 (4%)

Query: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
           D+   L+RA +L +++       L+  D    I + +    +H+  A G  + + LLL  
Sbjct: 332 DSGNYLKRALQLSDRKN------LVPRDEELCIYENK-VTPLHFLVAQGSVEQVRLLLAH 384

Query: 530 TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTE 589
                 ++ SG T  PL +AA +       +LL    D +  DE G   L  AA  G   
Sbjct: 385 EVDVDCQTASGYT--PLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDG 442

Query: 590 CVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPL 649
               L++ GA +  ++     TPLH +  N      RLL+    +P   ++ +A+G+TPL
Sbjct: 443 TARLLLDHGACVDAQER-EGWTPLHLAAQNNFENVARLLVSRQADP---NLHEAEGKTPL 498

Query: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
            +A  +GH+  V LL  + A +D       T LH  +  G    +Q LL+        D 
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558

Query: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
            G  PLH AAARG       LL+   S E      +QG+TPLH A Y G+   I +L E 
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLE---LPTHQGWTPLHLAAYKGHLEIIHLLAES 615

Query: 770 KCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828
                 +G   +TPLH A  +      S LL     +  +  +  G TPL  A       
Sbjct: 616 HANMGALGAVNWTPLHLAARHGEEAVVSALLQC--GADPNAAEQSGWTPLHLAVQRSTFL 673

Query: 829 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLA 888
            +  LL H A V+A +  G T   +AA  G    + +LV  A A L V+D    TPL LA
Sbjct: 674 SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV-EAGAQLDVQDGVSCTPLQLA 732



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 89/297 (29%), Positives = 131/297 (44%), Gaps = 16/297 (5%)

Query: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
           K TPLH  V  G    +RLLL    +   VD + A G TPL++A      D  +LLL   
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLA---HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418

Query: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
           A+ + VD  G   LH     G +   ++LL+    +  ++  G TPLH AA         
Sbjct: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN----FE 474

Query: 729 ELLQMALSEE-DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCA 786
            + ++ +S + D    + +G TPLH A Y G+ + +++L  Q         N  TPLH A
Sbjct: 475 NVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534

Query: 787 IINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVD 844
           +          LL  GA+  ++    D  G  PL  AA        ++LLR+ A +    
Sbjct: 535 VERGKVRAIQHLLKSGAVPDAL----DQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590

Query: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
           + G T L +AA  G    + +L  S  A++        TPLHLA   G E     +L
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAES-HANMGALGAVNWTPLHLAARHGEEAVVSALL 646



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 56/179 (31%), Positives = 85/179 (47%), Gaps = 7/179 (3%)

Query: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF-IGNPFTP 782
           A  LS+   +   +E+ C  +N+  TPLH+    G+   + +LL  +        + +TP
Sbjct: 340 ALQLSDRKNLVPRDEELCIYENK-VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTP 398

Query: 783 LHCAIINDHGN-CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
           L  A  +   + CA LL    D++ V   D+ G  PL  AA        +LLL H A V+
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADANRV---DEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455

Query: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
           A +  G T L +AA+N       +LV S QAD  + + +  TPLH+A   GH     L+
Sbjct: 456 AQEREGWTPLHLAAQNNFENVARLLV-SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 45/133 (33%), Positives = 62/133 (46%), Gaps = 5/133 (3%)

Query: 778 NPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
           N  TPLH  +         LLL   +D   V C+   G TPL  AA     +   LLL H
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVD---VDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            A  N VD  G   L  AA+NG  G   +L++   A +  ++++  TPLHLA     E  
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG-ACVDAQEREGWTPLHLAAQNNFENV 476

Query: 897 ALLILDKIQDESL 909
           A L++ +  D +L
Sbjct: 477 ARLLVSRQADPNL 489



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 7/120 (5%)

Query: 789 NDHGNCASLLLGAIDSSIVSCRDDK------GRTPLRAAAFADHVECLQLLLRHSAPVNA 842
           +D GN     L   D   +  RD++        TPL        VE ++LLL H   V+ 
Sbjct: 331 SDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDC 390

Query: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
              SG T L++AA++ Q     +L+    AD    D+D   PLH A   G +  A L+LD
Sbjct: 391 QTASGYTPLLIAAQDQQPDLCALLLAHG-ADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  180 bits (456), Expect = 6e-45
 Identities = 146/497 (29%), Positives = 235/497 (47%), Gaps = 29/497 (5%)

Query: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
           L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    NV D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266

Query: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
           RG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V +L+N
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228
            GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY G   
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
           +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SPL + 
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445

Query: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347
           A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+     
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
              L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SGA+ H
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA------------A 455
                G T L YA  N H    + L+  GA++    + GRT L  AA            +
Sbjct: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622

Query: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
              + N+    N H           L        +E LL + A+P+ R K+G   +  AA
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHL------AVVELLLAHGADPTHRLKDGSTMLIEAA 676

Query: 516 AYGHRQCLELLLERTNS 532
             GH   +  LL+  N+
Sbjct: 677 KGGHTNVVSYLLDYPNN 693



 Score =  170 bits (430), Expect = 6e-42
 Identities = 137/457 (29%), Positives = 221/457 (48%), Gaps = 8/457 (1%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60
           L+ +   VN    E  + L +A   G  E+ ++L+   A V  + N   +TPL  A +  
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
             + V++L+ H ADVN++     T L  A A   V   +V++   +++   +  G T L 
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179
            AA  GHVE+  +LL  GA IN    + +  AL  A Y GHLD+V  L+  GA+   K  
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
           + +T L  A  +G + V + LL+ G +++       + L +A   G   +   LI+ GAN
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298
           + + N+ G+TPL  AA   H  + + LL+  GA++N Q+++ +      A  G F+  + 
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
            LI+ G +I+      +TPL  A++ GH  L+  L  SGA+           L  A  N 
Sbjct: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579

Query: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD-KCGRTPL 417
           H+D    LL +G +++   + GRT L  AA  G++  ++ L S GA+ ++       T +
Sbjct: 580 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVV 639

Query: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
             A A  H   +E L+  GA+       G T L  AA
Sbjct: 640 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676



 Score =  160 bits (406), Expect = 4e-39
 Identities = 154/539 (28%), Positives = 235/539 (43%), Gaps = 47/539 (8%)

Query: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
           +L  A  +G V  V  LL +G ++N   ++    L  A   G+ ++  +L+   A V  +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
             KG  TPL AA+S G +++VK LL    +++  +  GNTAL  AC  G   +V  L++ 
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           GAN+   N NG TPL  AA++ H  +   +L+++GA +N  S + K              
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFK-------------- 372

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
                              + L +A   GH  ++  L  +GAD           L  A +
Sbjct: 373 ------------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
           + H +  R LL SG +++ P     + L  AA GG+VE   LL   GA+  + +  G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474

Query: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
           L  AA   H   +  L+  GAN+N +T++   TAL  A           L  A  +  EL
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI-EL 533

Query: 476 ERARELKEKEATLCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
             +  L E      LE   +LL + AN       G  ++ YA   GH    ++LL+    
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD-IRDEKGRTALDLAAFKGHTECV 591
              ES+ G T  PL  AA  GH   ++ L+    +++        T + LA   GH   V
Sbjct: 594 LEHESEGGRT--PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651

Query: 592 EALINPGA--SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           E L+  GA  +  +KD     T L  +   GHT  +  LL+  +N  +V   D     P
Sbjct: 652 ELLLAHGADPTHRLKDG---STMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPP 707



 Score =  156 bits (394), Expect = 1e-37
 Identities = 154/503 (30%), Positives = 223/503 (44%), Gaps = 27/503 (5%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELERAR 479
              H      L+  GAN+ E +D G T L  AA    +    +L    A+ N++      
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ----TE 502

Query: 480 ELKEKEATLCL--------EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTN 531
           E +E   TL          +FL++  A+  +        +  A+  GH + ++ LL    
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559

Query: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591
           +    + +G T   L  A  NGH    +VLLQ+  DL+   E GRT L  AA  GH   V
Sbjct: 560 NVHATTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617

Query: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
           + LI+ GA++         T +  +   GH   + LLL    +P    +KD  G T L+ 
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKD--GSTMLIE 674

Query: 652 AVAYGHIDAVSLLLEKEANVDTV 674
           A   GH + VS LL+   NV +V
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  149 bits (377), Expect = 9e-36
 Identities = 124/425 (29%), Positives = 195/425 (45%), Gaps = 7/425 (1%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           TPL  A+  G  +I++LL+L  A VN++     T L  A A    + V+VL+   A++  
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136
            ++N  TPL  AA+   V+ A V++   + +N  S+    +AL  A   GH++MV  LL 
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
            GA+      +   AL  A   GH++V  LL++ GA+V        +PL  AA  G + +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255
              L+  G  ++E+N  G T L  A   G + +V  L+  GAN+N Q      T L  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
                 +  + L+  GAD+ +      +PL   +  G     + L+ +G  +      G+
Sbjct: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID- 374
           T L  A   GH  + + L  +GAD          PL  AA   H    + L+S G  ++ 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434
                  T +  A AGG++  ++LL + GAD   + K G T L  AA   H + +  L+ 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 435 TGANV 439
              NV
Sbjct: 690 YPNNV 694



 Score =  146 bits (369), Expect = 8e-35
 Identities = 108/321 (33%), Positives = 158/321 (49%), Gaps = 38/321 (11%)

Query: 51   TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
            T L  A A   EE V VLI   A +  RDK   TPL +AA    V   E+++     +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 111  -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
             S+R   T L  A   G  E+V+LLLA+GAN    +  D   L  AA  G+++++ +L+N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 170  HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226
             GAE+  +   K G +PL  AA NG +  VK LL++G +I+ +I    NTAL +AC+ G+
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 227  DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG------------------------AL 262
              VV+ L+D  ANV      G TPL  AA+  +                         AL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 263  CL----------ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312
             +          ELL++ GA +++++K G +PL + +  G F   Q L+Q G ++D  D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 313  DGNTPLHVAARYGHELLINTL 333
               TPL  A R GH  ++  L
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYL 1377



 Score =  141 bits (355), Expect = 3e-33
 Identities = 117/402 (29%), Positives = 186/402 (46%), Gaps = 8/402 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357
            L+Q G +++   + G TPL  AAR GH   +  L + GA+  +   ++    + LA   
Sbjct: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645

Query: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
            H      LL+ G +     K G T L  AA GG+   +  L
Sbjct: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687



 Score =  138 bits (348), Expect = 2e-32
 Identities = 142/515 (27%), Positives = 228/515 (44%), Gaps = 25/515 (4%)

Query: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249

Query: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367

Query: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425

Query: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 691 EECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749
           EE V +LL Q  +I  + +    T L  A   G +     L++     E  C       T
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS------T 537

Query: 750 PLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
           PL  A   G+   ++ LL              T L  A  N H + A +LL A   + + 
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA--GADLE 595

Query: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILV 867
              + GRTPL  AA A H+  +Q L+   A VN A  N+  T + +A   G    V++L+
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655

Query: 868 NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
            +  AD T + KD +T L  A   GH      +LD
Sbjct: 656 -AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  137 bits (345), Expect = 5e-32
 Identities = 119/402 (29%), Positives = 186/402 (46%), Gaps = 17/402 (4%)

Query: 103  PLLSSVNV---SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMG 159
            P+  SV++   ++    TAL  A   GH E+V++L+A+ A I   DKK    L  AA  G
Sbjct: 1040 PVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAG 1099

Query: 160  HLDVVALLINHGAEVTCKDKKGY-TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
            H+ VV +L++ G ++  + ++   TPL  A S G+  VV  LL  G   +  NV   T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 219  HIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGALCLELLVNNGADVNI 276
             +A   G   ++  L++ GA +N    +  G +PL  AA + H    ++LL++ G+D+N 
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH-VPAVKLLLDMGSDINA 1218

Query: 277  QSKDGKSP-LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRT 335
            Q +  ++  L +    GR      L+     ++   K G TPL  AA  G+  +   L  
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278

Query: 336  SGADTAKCGIHSM--FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
             GAD     + S     L +AA   H   C  L+  G  ID  +K G T L  A+ GG+ 
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338

Query: 394  ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
            + ++LL  +GAD    D    TPL  A    H   ++ LV     VN+         + A
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV---KEVNQFPSDIECMRYIA 1395

Query: 454  AASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
              +D    K +L   H   E + +A++ +  EA      LL+
Sbjct: 1396 TITD----KELLKKCHQCVETIVKAKDQQAAEANKNASILLK 1433



 Score =  134 bits (337), Expect = 4e-31
 Identities = 119/408 (29%), Positives = 183/408 (44%), Gaps = 32/408 (7%)

Query: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
           D  +K   T L AA++GG ++ +KLL    AD + +   G T L YA A      ++ L+
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325

Query: 434 TTGANVNETDDWGRTALHYAA-ASDMDRNKTILG-----NAHDNSEELERARELKEKEAT 487
             GAN+ + ++ G T L  AA A  ++  + +L      N H N        E KE   T
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALT 377

Query: 488 LC--------LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
           L         + FLL+  A+   +  E + ++  A   GH +   LLL+        +DS
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599
              +SPL LAA  GH +   +L++   +L+  +++G T L  AA +GH E V  L+  GA
Sbjct: 438 --FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
           +I  +   T+ T L  +   G +     L++   + E          TPLM A   GH++
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEGHLE 549

Query: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            V  LL   ANV      G TAL      GH +   +LL+    +  +   GRTPL  AA
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609

Query: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
             GH   +  L+    +        N  +T +  AC  G+   +E+LL
Sbjct: 610 RAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLL 655



 Score =  129 bits (325), Expect = 1e-29
 Identities = 139/522 (26%), Positives = 220/522 (42%), Gaps = 43/522 (8%)

Query: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYAAA 422
           RKLL  G  ++   + G + L  A + G  E  ++L +  A+   +   G  TPL  A++
Sbjct: 222 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASS 281

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
             +   ++ L+   A+VN     G TAL YA A          G   D            
Sbjct: 282 GGYLDIVKLLLLHDADVNSQSATGNTALTYACA----------GGFVD------------ 319

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
                  ++ LL   AN    ++ G+  +  AA+ GH +   +LL+   +G     +   
Sbjct: 320 ------IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFK 372

Query: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
           +S L LA Y GH   +  LL++  D + + ++  TAL  A   GH E    L++ GA + 
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432

Query: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
           +  + +  +PL  +   GH     LL+E   N E V+    +G TPLM A   GH + V+
Sbjct: 433 MPAD-SFESPLTLAACGGHVELAALLIERGANLEEVN---DEGYTPLMEAAREGHEEMVA 488

Query: 663 LLLEKEANVDT-VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
           LLL + AN++   +    TAL      G  E    L++    I    S   TPL  A+  
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545

Query: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF- 780
           GH   +  LL    S  +       G T L +AC NG+ +  +VLL+     +       
Sbjct: 546 GHLELVKYLLA---SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602

Query: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
           TPL  A    H  C    L +  +++     +   T +  A    H+  ++LLL H A  
Sbjct: 603 TPLMKAARAGH-LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
                 G T L+ AA+ G    V  L++     L+V   D++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703



 Score =  124 bits (312), Expect = 3e-28
 Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 11/320 (3%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAVAS 59
            +LI +   +   D +  TPL +AA  G   ++E+L+  G  + A+      TPL  A + 
Sbjct: 1073 VLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSG 1132

Query: 60   RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN--VSDRGGRT 117
              +E V +L+   A+   R+ +  TPL +AA+   V   ++++   + +N     + G +
Sbjct: 1133 GRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 1192

Query: 118  ALHHAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTC 176
             L  AA+NGHV  V LLL  G++INA  + +R  AL  A + G  +VV+LL++  A V  
Sbjct: 1193 PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252

Query: 177  KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG--NTALHIACYNGQDAVVNELI 234
            + K G TPL  AAS G   V + LL+ G +++   V    +TAL IA   G       LI
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 235  DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRF 294
              GA+++  N  G TPL  A+   H  + ++LLV  GADV+       +PL      G  
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDV-VQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371

Query: 295  TRSQTLI----QNGGEIDCV 310
               Q L+    Q   +I+C+
Sbjct: 1372 KVVQYLVKEVNQFPSDIECM 1391



 Score =  120 bits (301), Expect = 6e-27
 Identities = 113/357 (31%), Positives = 158/357 (44%), Gaps = 24/357 (6%)

Query: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
            L LA   GH + + VL+     ++ RD+KG T L LAA  GH   VE L++ G  I  + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
              TK TPL  +   G    + LLL    N E  +V D    TPL LA + G+++ + +LL
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175

Query: 666  E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
                E N  T   LG + L    M GH   V++LL+    I  + ++   T L  A  +G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
             A  +S LL    + E    +   G TPL  A   G      VLL++         P   
Sbjct: 1236 RAEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292

Query: 781  -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
             T L  A    H     LL+     + +  R+ KG TPL  A+   H + +QLL++  A 
Sbjct: 1293 DTALTIAADKGHYKFCELLIHR--GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350

Query: 840  VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQADL-------TVKDKDLNTPLH 886
            V+A DN   T LM A   G    V  L   VN   +D+       T+ DK+L    H
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCH 1407



 Score =  102 bits (255), Expect = 1e-21
 Identities = 101/355 (28%), Positives = 157/355 (44%), Gaps = 33/355 (9%)

Query: 245  NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
            +N  T L  A A  H  L + +L+   A +  + K G +PL + A  G     + L+  G
Sbjct: 1053 SNHDTALTLACAGGHEEL-VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 305  GEIDCV-DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363
            G+I+   ++  +TPL +A   G + +++ L   GA+     +    PL LAA   + +  
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 364  RKLLSSGFEID--TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYA 420
            + LL++G EI+  T  K G + L  AA  G+V  +KLL   G+D + + +  R T L  A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 421  AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
                    +  L+   ANV      G T L  AA+                    E  R 
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY----------------AEVGRV 1275

Query: 481  LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
            L +K A +           PS RD     ++  AA  GH +  ELL+ R       +  G
Sbjct: 1276 LLDKGADV------NAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325

Query: 541  ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
             T  PL LA+  GH   +++L+Q+  D+D  D +  T L  A  KGH + V+ L+
Sbjct: 1326 NT--PLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  101 bits (252), Expect = 3e-21
 Identities = 90/316 (28%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 493  LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAAY 551
            L+  DA    RDK+G+  +  AA  GH   +E+LL++   G  E+ S  TK +PL LA  
Sbjct: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK--GGDIEAQSERTKDTPLSLACS 1131

Query: 552  NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKR 610
             G  + +++LL    + + R+    T L LAA  G+   ++ L+N GA I  +  +    
Sbjct: 1132 GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191

Query: 611  TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
            +PL  + +NGH   ++LLL++  +  A    +    T L LA   G  + VSLLL+++AN
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINA--QIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249

Query: 671  VDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGHATWLS 728
            V+     G T L      G+ E  ++LL++  +V+     S   T L  AA +GH  +  
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309

Query: 729  ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN-PFTPLHCAI 787
             L+      +    ++ +G TPL  A   G+ + +++L++         N   TPL  A 
Sbjct: 1310 LLIHRGAHID---VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAF 1366

Query: 788  INDHGNCASLLLGAID 803
               H      L+  ++
Sbjct: 1367 RKGHVKVVQYLVKEVN 1382



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 14/250 (5%)

Query: 660  AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            +V +    E+N DT   L C         GHEE V +L+ ++  I  +D +G TPL  AA
Sbjct: 1044 SVDIDAHTESNHDTALTLACAG-------GHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096

Query: 720  ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778
              GH   +  LL      E     +    TPL  AC  G +  +++LL +   ++    +
Sbjct: 1097 TAGHVGVVEILLDKGGDIE--AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 779  PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837
             +TPL  A    + N   +LL A  + I S    K G +PL  AA   HV  ++LLL   
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 838  APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            + +NA ++ +  TAL +A   G+A  V +L++  +A++  + K   TPL  A S G+ + 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 897  ALLILDKIQD 906
              ++LDK  D
Sbjct: 1273 GRVLLDKGAD 1282



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 9/279 (3%)

Query: 642  DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
            ++   T L LA A GH + VS+L+ ++A ++  D  G T L      GH   V++LL++ 
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 702  VSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
              I  +  R + TPL  A + G    +  LL    ++E    ++   YTPL  A   G  
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE---HRNVSDYTPLSLAASGGYV 1168

Query: 761  NCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
            N I++LL          G+    +PL  A +N H     LLL  + S I +  +    T 
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQIETNRNTA 1227

Query: 818  LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQADLTV 876
            L  A F    E + LLL   A V     +G T LM AA  G A    +L++  A  +   
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287

Query: 877  KDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
                 +T L +A  KGH K   L++ +     + N+K N
Sbjct: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 38/285 (13%)

Query: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282

Query: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339

Query: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
           TPL  A   G+     VLL+               H A IN H N               
Sbjct: 340 TPLMEAASAGHVEVARVLLD---------------HGAGINTHSN--------------- 369

Query: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
              +   + L  A +  H++ ++ LL   A      +   TALM A  +G      +L++
Sbjct: 370 ---EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           S  A + +      +PL LA   GH + A L++++  +   +N++
Sbjct: 427 SG-AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL      +  GN    TPL  A    + +   LLL  + 
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL--LH 294

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A     V+ +++LL   A +   + +G T LM AA  G     
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L++      T  ++   + L LAC KGH      +L+   D E   +E + AL
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 9/108 (8%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +LIH+   ++  + +  TPL +A+  G  ++++LL+ +GA V+A DN  +TPL  A    
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAA------ANKAVKCAEVII 102
              + VQ L+K   +VN    + +   ++A         K  +C E I+
Sbjct: 1370 HVKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  180 bits (456), Expect = 6e-45
 Identities = 146/497 (29%), Positives = 235/497 (47%), Gaps = 29/497 (5%)

Query: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
           L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    NV D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266

Query: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
           RG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V +L+N
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228
            GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY G   
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
           +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SPL + 
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445

Query: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347
           A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+     
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
              L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SGA+ H
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA------------A 455
                G T L YA  N H    + L+  GA++    + GRT L  AA            +
Sbjct: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622

Query: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
              + N+    N H           L        +E LL + A+P+ R K+G   +  AA
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHL------AVVELLLAHGADPTHRLKDGSTMLIEAA 676

Query: 516 AYGHRQCLELLLERTNS 532
             GH   +  LL+  N+
Sbjct: 677 KGGHTNVVSYLLDYPNN 693



 Score =  170 bits (430), Expect = 6e-42
 Identities = 137/457 (29%), Positives = 221/457 (48%), Gaps = 8/457 (1%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60
           L+ +   VN    E  + L +A   G  E+ ++L+   A V  + N   +TPL  A +  
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
             + V++L+ H ADVN++     T L  A A   V   +V++   +++   +  G T L 
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179
            AA  GHVE+  +LL  GA IN    + +  AL  A Y GHLD+V  L+  GA+   K  
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
           + +T L  A  +G + V + LL+ G +++       + L +A   G   +   LI+ GAN
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298
           + + N+ G+TPL  AA   H  + + LL+  GA++N Q+++ +      A  G F+  + 
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
            LI+ G +I+      +TPL  A++ GH  L+  L  SGA+           L  A  N 
Sbjct: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579

Query: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD-KCGRTPL 417
           H+D    LL +G +++   + GRT L  AA  G++  ++ L S GA+ ++       T +
Sbjct: 580 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVV 639

Query: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
             A A  H   +E L+  GA+       G T L  AA
Sbjct: 640 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676



 Score =  160 bits (406), Expect = 4e-39
 Identities = 154/539 (28%), Positives = 235/539 (43%), Gaps = 47/539 (8%)

Query: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
           +L  A  +G V  V  LL +G ++N   ++    L  A   G+ ++  +L+   A V  +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
             KG  TPL AA+S G +++VK LL    +++  +  GNTAL  AC  G   +V  L++ 
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           GAN+   N NG TPL  AA++ H  +   +L+++GA +N  S + K              
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFK-------------- 372

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
                              + L +A   GH  ++  L  +GAD           L  A +
Sbjct: 373 ------------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
           + H +  R LL SG +++ P     + L  AA GG+VE   LL   GA+  + +  G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474

Query: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
           L  AA   H   +  L+  GAN+N +T++   TAL  A           L  A  +  EL
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI-EL 533

Query: 476 ERARELKEKEATLCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
             +  L E      LE   +LL + AN       G  ++ YA   GH    ++LL+    
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD-IRDEKGRTALDLAAFKGHTECV 591
              ES+ G T  PL  AA  GH   ++ L+    +++        T + LA   GH   V
Sbjct: 594 LEHESEGGRT--PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651

Query: 592 EALINPGA--SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           E L+  GA  +  +KD     T L  +   GHT  +  LL+  +N  +V   D     P
Sbjct: 652 ELLLAHGADPTHRLKDG---STMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPP 707



 Score =  156 bits (394), Expect = 1e-37
 Identities = 154/503 (30%), Positives = 223/503 (44%), Gaps = 27/503 (5%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELERAR 479
              H      L+  GAN+ E +D G T L  AA    +    +L    A+ N++      
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ----TE 502

Query: 480 ELKEKEATLCL--------EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTN 531
           E +E   TL          +FL++  A+  +        +  A+  GH + ++ LL    
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559

Query: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591
           +    + +G T   L  A  NGH    +VLLQ+  DL+   E GRT L  AA  GH   V
Sbjct: 560 NVHATTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617

Query: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
           + LI+ GA++         T +  +   GH   + LLL    +P    +KD  G T L+ 
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKD--GSTMLIE 674

Query: 652 AVAYGHIDAVSLLLEKEANVDTV 674
           A   GH + VS LL+   NV +V
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  149 bits (377), Expect = 9e-36
 Identities = 124/425 (29%), Positives = 195/425 (45%), Gaps = 7/425 (1%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           TPL  A+  G  +I++LL+L  A VN++     T L  A A    + V+VL+   A++  
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136
            ++N  TPL  AA+   V+ A V++   + +N  S+    +AL  A   GH++MV  LL 
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
            GA+      +   AL  A   GH++V  LL++ GA+V        +PL  AA  G + +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255
              L+  G  ++E+N  G T L  A   G + +V  L+  GAN+N Q      T L  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
                 +  + L+  GAD+ +      +PL   +  G     + L+ +G  +      G+
Sbjct: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID- 374
           T L  A   GH  + + L  +GAD          PL  AA   H    + L+S G  ++ 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434
                  T +  A AGG++  ++LL + GAD   + K G T L  AA   H + +  L+ 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 435 TGANV 439
              NV
Sbjct: 690 YPNNV 694



 Score =  146 bits (369), Expect = 8e-35
 Identities = 108/321 (33%), Positives = 158/321 (49%), Gaps = 38/321 (11%)

Query: 51   TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
            T L  A A   EE V VLI   A +  RDK   TPL +AA    V   E+++     +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 111  -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
             S+R   T L  A   G  E+V+LLLA+GAN    +  D   L  AA  G+++++ +L+N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 170  HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226
             GAE+  +   K G +PL  AA NG +  VK LL++G +I+ +I    NTAL +AC+ G+
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 227  DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG------------------------AL 262
              VV+ L+D  ANV      G TPL  AA+  +                         AL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 263  CL----------ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312
             +          ELL++ GA +++++K G +PL + +  G F   Q L+Q G ++D  D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 313  DGNTPLHVAARYGHELLINTL 333
               TPL  A R GH  ++  L
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYL 1377



 Score =  141 bits (355), Expect = 3e-33
 Identities = 117/402 (29%), Positives = 186/402 (46%), Gaps = 8/402 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357
            L+Q G +++   + G TPL  AAR GH   +  L + GA+  +   ++    + LA   
Sbjct: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645

Query: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
            H      LL+ G +     K G T L  AA GG+   +  L
Sbjct: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687



 Score =  138 bits (348), Expect = 2e-32
 Identities = 142/515 (27%), Positives = 228/515 (44%), Gaps = 25/515 (4%)

Query: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249

Query: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367

Query: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425

Query: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 691 EECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749
           EE V +LL Q  +I  + +    T L  A   G +     L++     E  C       T
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS------T 537

Query: 750 PLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
           PL  A   G+   ++ LL              T L  A  N H + A +LL A   + + 
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA--GADLE 595

Query: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILV 867
              + GRTPL  AA A H+  +Q L+   A VN A  N+  T + +A   G    V++L+
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655

Query: 868 NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
            +  AD T + KD +T L  A   GH      +LD
Sbjct: 656 -AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  137 bits (345), Expect = 5e-32
 Identities = 119/402 (29%), Positives = 186/402 (46%), Gaps = 17/402 (4%)

Query: 103  PLLSSVNV---SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMG 159
            P+  SV++   ++    TAL  A   GH E+V++L+A+ A I   DKK    L  AA  G
Sbjct: 1040 PVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAG 1099

Query: 160  HLDVVALLINHGAEVTCKDKKGY-TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
            H+ VV +L++ G ++  + ++   TPL  A S G+  VV  LL  G   +  NV   T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 219  HIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGALCLELLVNNGADVNI 276
             +A   G   ++  L++ GA +N    +  G +PL  AA + H    ++LL++ G+D+N 
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH-VPAVKLLLDMGSDINA 1218

Query: 277  QSKDGKSP-LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRT 335
            Q +  ++  L +    GR      L+     ++   K G TPL  AA  G+  +   L  
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278

Query: 336  SGADTAKCGIHSM--FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
             GAD     + S     L +AA   H   C  L+  G  ID  +K G T L  A+ GG+ 
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338

Query: 394  ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
            + ++LL  +GAD    D    TPL  A    H   ++ LV     VN+         + A
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV---KEVNQFPSDIECMRYIA 1395

Query: 454  AASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
              +D    K +L   H   E + +A++ +  EA      LL+
Sbjct: 1396 TITD----KELLKKCHQCVETIVKAKDQQAAEANKNASILLK 1433



 Score =  134 bits (337), Expect = 4e-31
 Identities = 119/408 (29%), Positives = 183/408 (44%), Gaps = 32/408 (7%)

Query: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
           D  +K   T L AA++GG ++ +KLL    AD + +   G T L YA A      ++ L+
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325

Query: 434 TTGANVNETDDWGRTALHYAA-ASDMDRNKTILG-----NAHDNSEELERARELKEKEAT 487
             GAN+ + ++ G T L  AA A  ++  + +L      N H N        E KE   T
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALT 377

Query: 488 LC--------LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
           L         + FLL+  A+   +  E + ++  A   GH +   LLL+        +DS
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599
              +SPL LAA  GH +   +L++   +L+  +++G T L  AA +GH E V  L+  GA
Sbjct: 438 --FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
           +I  +   T+ T L  +   G +     L++   + E          TPLM A   GH++
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEGHLE 549

Query: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            V  LL   ANV      G TAL      GH +   +LL+    +  +   GRTPL  AA
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609

Query: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
             GH   +  L+    +        N  +T +  AC  G+   +E+LL
Sbjct: 610 RAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLL 655



 Score =  129 bits (325), Expect = 1e-29
 Identities = 139/522 (26%), Positives = 220/522 (42%), Gaps = 43/522 (8%)

Query: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYAAA 422
           RKLL  G  ++   + G + L  A + G  E  ++L +  A+   +   G  TPL  A++
Sbjct: 222 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASS 281

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
             +   ++ L+   A+VN     G TAL YA A          G   D            
Sbjct: 282 GGYLDIVKLLLLHDADVNSQSATGNTALTYACA----------GGFVD------------ 319

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
                  ++ LL   AN    ++ G+  +  AA+ GH +   +LL+   +G     +   
Sbjct: 320 ------IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFK 372

Query: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
           +S L LA Y GH   +  LL++  D + + ++  TAL  A   GH E    L++ GA + 
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432

Query: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
           +  + +  +PL  +   GH     LL+E   N E V+    +G TPLM A   GH + V+
Sbjct: 433 MPAD-SFESPLTLAACGGHVELAALLIERGANLEEVN---DEGYTPLMEAAREGHEEMVA 488

Query: 663 LLLEKEANVDT-VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
           LLL + AN++   +    TAL      G  E    L++    I    S   TPL  A+  
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545

Query: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF- 780
           GH   +  LL    S  +       G T L +AC NG+ +  +VLL+     +       
Sbjct: 546 GHLELVKYLLA---SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602

Query: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
           TPL  A    H  C    L +  +++     +   T +  A    H+  ++LLL H A  
Sbjct: 603 TPLMKAARAGH-LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
                 G T L+ AA+ G    V  L++     L+V   D++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703



 Score =  124 bits (312), Expect = 3e-28
 Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 11/320 (3%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAVAS 59
            +LI +   +   D +  TPL +AA  G   ++E+L+  G  + A+      TPL  A + 
Sbjct: 1073 VLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSG 1132

Query: 60   RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN--VSDRGGRT 117
              +E V +L+   A+   R+ +  TPL +AA+   V   ++++   + +N     + G +
Sbjct: 1133 GRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 1192

Query: 118  ALHHAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTC 176
             L  AA+NGHV  V LLL  G++INA  + +R  AL  A + G  +VV+LL++  A V  
Sbjct: 1193 PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252

Query: 177  KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG--NTALHIACYNGQDAVVNELI 234
            + K G TPL  AAS G   V + LL+ G +++   V    +TAL IA   G       LI
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 235  DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRF 294
              GA+++  N  G TPL  A+   H  + ++LLV  GADV+       +PL      G  
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDV-VQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371

Query: 295  TRSQTLI----QNGGEIDCV 310
               Q L+    Q   +I+C+
Sbjct: 1372 KVVQYLVKEVNQFPSDIECM 1391



 Score =  120 bits (301), Expect = 6e-27
 Identities = 113/357 (31%), Positives = 158/357 (44%), Gaps = 24/357 (6%)

Query: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
            L LA   GH + + VL+     ++ RD+KG T L LAA  GH   VE L++ G  I  + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
              TK TPL  +   G    + LLL    N E  +V D    TPL LA + G+++ + +LL
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175

Query: 666  E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
                E N  T   LG + L    M GH   V++LL+    I  + ++   T L  A  +G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
             A  +S LL    + E    +   G TPL  A   G      VLL++         P   
Sbjct: 1236 RAEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292

Query: 781  -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
             T L  A    H     LL+     + +  R+ KG TPL  A+   H + +QLL++  A 
Sbjct: 1293 DTALTIAADKGHYKFCELLIHR--GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350

Query: 840  VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQADL-------TVKDKDLNTPLH 886
            V+A DN   T LM A   G    V  L   VN   +D+       T+ DK+L    H
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCH 1407



 Score =  102 bits (255), Expect = 1e-21
 Identities = 101/355 (28%), Positives = 157/355 (44%), Gaps = 33/355 (9%)

Query: 245  NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
            +N  T L  A A  H  L + +L+   A +  + K G +PL + A  G     + L+  G
Sbjct: 1053 SNHDTALTLACAGGHEEL-VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 305  GEIDCV-DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363
            G+I+   ++  +TPL +A   G + +++ L   GA+     +    PL LAA   + +  
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 364  RKLLSSGFEID--TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYA 420
            + LL++G EI+  T  K G + L  AA  G+V  +KLL   G+D + + +  R T L  A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 421  AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
                    +  L+   ANV      G T L  AA+                    E  R 
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY----------------AEVGRV 1275

Query: 481  LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
            L +K A +           PS RD     ++  AA  GH +  ELL+ R       +  G
Sbjct: 1276 LLDKGADV------NAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325

Query: 541  ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
             T  PL LA+  GH   +++L+Q+  D+D  D +  T L  A  KGH + V+ L+
Sbjct: 1326 NT--PLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  101 bits (252), Expect = 3e-21
 Identities = 90/316 (28%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 493  LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAAY 551
            L+  DA    RDK+G+  +  AA  GH   +E+LL++   G  E+ S  TK +PL LA  
Sbjct: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK--GGDIEAQSERTKDTPLSLACS 1131

Query: 552  NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKR 610
             G  + +++LL    + + R+    T L LAA  G+   ++ L+N GA I  +  +    
Sbjct: 1132 GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191

Query: 611  TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
            +PL  + +NGH   ++LLL++  +  A    +    T L LA   G  + VSLLL+++AN
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINA--QIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249

Query: 671  VDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGHATWLS 728
            V+     G T L      G+ E  ++LL++  +V+     S   T L  AA +GH  +  
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309

Query: 729  ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN-PFTPLHCAI 787
             L+      +    ++ +G TPL  A   G+ + +++L++         N   TPL  A 
Sbjct: 1310 LLIHRGAHID---VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAF 1366

Query: 788  INDHGNCASLLLGAID 803
               H      L+  ++
Sbjct: 1367 RKGHVKVVQYLVKEVN 1382



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 14/250 (5%)

Query: 660  AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            +V +    E+N DT   L C         GHEE V +L+ ++  I  +D +G TPL  AA
Sbjct: 1044 SVDIDAHTESNHDTALTLACAG-------GHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096

Query: 720  ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778
              GH   +  LL      E     +    TPL  AC  G +  +++LL +   ++    +
Sbjct: 1097 TAGHVGVVEILLDKGGDIE--AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 779  PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837
             +TPL  A    + N   +LL A  + I S    K G +PL  AA   HV  ++LLL   
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 838  APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            + +NA ++ +  TAL +A   G+A  V +L++  +A++  + K   TPL  A S G+ + 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 897  ALLILDKIQD 906
              ++LDK  D
Sbjct: 1273 GRVLLDKGAD 1282



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 9/279 (3%)

Query: 642  DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
            ++   T L LA A GH + VS+L+ ++A ++  D  G T L      GH   V++LL++ 
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 702  VSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
              I  +  R + TPL  A + G    +  LL    ++E    ++   YTPL  A   G  
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE---HRNVSDYTPLSLAASGGYV 1168

Query: 761  NCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
            N I++LL          G+    +PL  A +N H     LLL  + S I +  +    T 
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQIETNRNTA 1227

Query: 818  LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQADLTV 876
            L  A F    E + LLL   A V     +G T LM AA  G A    +L++  A  +   
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287

Query: 877  KDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
                 +T L +A  KGH K   L++ +     + N+K N
Sbjct: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 38/285 (13%)

Query: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282

Query: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339

Query: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
           TPL  A   G+     VLL+               H A IN H N               
Sbjct: 340 TPLMEAASAGHVEVARVLLD---------------HGAGINTHSN--------------- 369

Query: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
              +   + L  A +  H++ ++ LL   A      +   TALM A  +G      +L++
Sbjct: 370 ---EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           S  A + +      +PL LA   GH + A L++++  +   +N++
Sbjct: 427 SG-AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL      +  GN    TPL  A    + +   LLL  + 
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL--LH 294

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A     V+ +++LL   A +   + +G T LM AA  G     
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L++      T  ++   + L LAC KGH      +L+   D E   +E + AL
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 9/108 (8%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +LIH+   ++  + +  TPL +A+  G  ++++LL+ +GA V+A DN  +TPL  A    
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAA------ANKAVKCAEVII 102
              + VQ L+K   +VN    + +   ++A         K  +C E I+
Sbjct: 1370 HVKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  173 bits (439), Expect = 6e-43
 Identities = 124/384 (32%), Positives = 190/384 (49%), Gaps = 30/384 (7%)

Query: 20  LHVAAFLGDAEIIELLILSGARVN--AKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           LH AA   +   ++ LI  G RVN  A++++    LH A  +  E+AV++L++H A V+ 
Sbjct: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
            D        V A  +A  C                 G  AL  +A  GH+ ++ +L+  
Sbjct: 77  EDA-------VGALTEARLCF----------------GMNALLLSAWFGHLRILQILVNS 113

Query: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--DKKGYTPLHAAASNGQIN 195
           GA I+   K     LH AA  GH+ V+A ++    +V     DK G T  H AA +GQ++
Sbjct: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173

Query: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA 255
            +  L+  G + +  +  GNTALH+A   G  AV+  L+D G ++ + N  G T LH AA
Sbjct: 174 ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAA 233

Query: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
             +H   C++LL+  G+ VN  ++   S LH  A+ G    S+ LI  GG  + VD  G 
Sbjct: 234 GGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA 292

Query: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375
           +PLH+A R+    L+  L  S +D          PLHLAA +A  D    LL +G +++ 
Sbjct: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352

Query: 376 PDKFGRTCLHAAAAGGNVECIKLL 399
            DK G+T L  A    +V  + ++
Sbjct: 353 RDKQGKTALAVAVRSNHVSLVDMI 376



 Score =  142 bits (359), Expect = 1e-33
 Identities = 110/384 (28%), Positives = 171/384 (44%), Gaps = 46/384 (11%)

Query: 86  LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
           LH AA    V   + +I    +    +  GR ALH AA  GH + V LLL   A ++  D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 146 KKDR----------RALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195
                          AL  +A+ GHL ++ +L+N GA++ C+ K G T LH AA  G + 
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 196 VVKHLLN--LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253
           V+  ++     V +D ++  G TA H A  +GQ       +D                  
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ-------LD------------------ 173

Query: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD 313
                     L+ LV +G D N++ K+G + LH+ A  G     Q L+  G +++  + +
Sbjct: 174 ---------ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224

Query: 314 GNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373
           G T LH AA   H   +  L  +G+        ++  LH AAL+   D  R L+ +G   
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284

Query: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
           +  D  G + LH A        ++LL +S +D +  D   +TPLH AA +      + L+
Sbjct: 285 NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344

Query: 434 TTGANVNETDDWGRTALHYAAASD 457
             G ++N  D  G+TAL  A  S+
Sbjct: 345 IAGVDLNLRDKQGKTALAVAVRSN 368



 Score =  140 bits (353), Expect = 5e-33
 Identities = 114/445 (25%), Positives = 192/445 (43%), Gaps = 54/445 (12%)

Query: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
           LH AA   +V  +  L+ +  N  A +   R ALHWAA  GH   V LL+ H A V  +D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
             G      A +  ++                  +G  AL ++ + G   ++  L++ GA
Sbjct: 79  AVG------ALTEARL-----------------CFGMNALLLSAWFGHLRILQILVNSGA 115

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD--GKSPLHMTAVHGRFTR 296
            ++  + +G T LH AA   H  + L  ++ +  DV +   D  G++  H  A HG+   
Sbjct: 116 KIHCESKDGLTLLHCAAQKGHVPV-LAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
              L+ +G + +  DK+GNT LH+AA  GH  ++  L   G D  +     +  LH AA 
Sbjct: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
            +H DC + LL +G  ++   +   +CLH AA  G+ +  ++L  +G   +  D  G +P
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASP 294

Query: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELE 476
           LH A  +     +  L+ + ++VN  D+  +T LH AA                      
Sbjct: 295 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAA---------------------- 332

Query: 477 RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEE 536
                 E       + LL    + ++RDK+G  ++  A    H   ++++++       E
Sbjct: 333 ------EHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWE 386

Query: 537 SDSGATKSPLHLAAYNGHHQALEVL 561
            D  +  S   L+    H Q  + L
Sbjct: 387 KDHPSDPSGKSLSFKQDHRQETQQL 411



 Score =  137 bits (345), Expect = 5e-32
 Identities = 113/413 (27%), Positives = 180/413 (43%), Gaps = 56/413 (13%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           LH AA    +  ++ L+   V     N  G  ALH A   G +  V  L+++ A V++ +
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 245 NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
             G        A T   LC                 G + L ++A  G     Q L+ +G
Sbjct: 79  AVG--------ALTEARLCF----------------GMNALLLSAWFGHLRILQILVNSG 114

Query: 305 GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHSDC 362
            +I C  KDG T LH AA+ GH  ++  +     D A   +  +     H AA +   D 
Sbjct: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174

Query: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
              L+ SG + +  DK G T LH AA  G++  ++ L   G D  +++  G T LH AA 
Sbjct: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
             H  C++ L+  G+ VN       + LHYAA S               SE++ R     
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS--------------GSEDVSRV---- 276

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
                     L+      ++ D +G + +H A  +     + LL+  ++S     D+   
Sbjct: 277 ----------LIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI-NSDSDVNAVDN-RQ 324

Query: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
           ++PLHLAA +      ++LL + VDL++RD++G+TAL +A    H   V+ +I
Sbjct: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score =  125 bits (314), Expect = 2e-28
 Identities = 101/365 (27%), Positives = 170/365 (46%), Gaps = 15/365 (4%)

Query: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
           LH AA   +   ++ L+   V+   R+  GR AL  AA  GH + V  L+   A++  +D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 606 NVTKRTP------LHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
            V   T       ++A +++     LR+L  + ++   +  +   G T L  A   GH+ 
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 660 AVSLLLE--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
            ++ ++E  ++  +D VD LG TA HR    G  + +  L+        KD  G T LH 
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

Query: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-KCFRKFI 776
           AA RGH   L  L+ + L  E+   ++ +G T LH A    + +C+++LL          
Sbjct: 199 AAGRGHMAVLQRLVDIGLDLEE---QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255

Query: 777 GNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
               + LH A ++   + + +L+ A      +  D +G +PL  A   +    ++LL+  
Sbjct: 256 QKNLSCLHYAALSGSEDVSRVLIHA--GGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313

Query: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            + VNAVDN  +T L +AAE+      D+L+  A  DL ++DK   T L +A    H   
Sbjct: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDLNLRDKQGKTALAVAVRSNHVSL 372

Query: 897 ALLIL 901
             +I+
Sbjct: 373 VDMII 377



 Score =  119 bits (298), Expect = 1e-26
 Identities = 104/359 (28%), Positives = 165/359 (45%), Gaps = 24/359 (6%)

Query: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK------ 543
           ++ L+    N   R+  G  ++H+AA  GH Q + LLLE   +  EE   GA        
Sbjct: 31  MQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90

Query: 544 --SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
             + L L+A+ GH + L++L+ S   +    + G T L  AA KGH   V A I      
Sbjct: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP-VLAFIMEDLED 149

Query: 602 FVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
              D+V K  RT  H +  +G    L  L+    +    +VKD +G T L LA   GH+ 
Sbjct: 150 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH---NVKDKEGNTALHLAAGRGHMA 206

Query: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            +  L++   +++  +  G TALH      H +CVQ+LL    ++     +  + LHYAA
Sbjct: 207 VLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266

Query: 720 ARGHATWLSELLQMALSEEDCCFK--DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777
             G     SE +   L     C    D+QG +PLH A  +     + +L+        + 
Sbjct: 267 LSG-----SEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321

Query: 778 N-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
           N   TPLH A  +   + A +LL  I    ++ RD +G+T L  A  ++HV  + ++++
Sbjct: 322 NRQQTPLHLAAEHAWQDIADMLL--IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378



 Score =  114 bits (286), Expect = 3e-25
 Identities = 97/337 (28%), Positives = 157/337 (46%), Gaps = 22/337 (6%)

Query: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGR----------TALDLAAFKGHTECVEALI 595
           LH AA  GH QA+ +LL+    +D  D  G            AL L+A+ GH   ++ L+
Sbjct: 52  LHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILV 111

Query: 596 NPGASIFV--KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653
           N GA I    KD +T    LH +   GH   L  ++E  ++  A+D  D  G+T    A 
Sbjct: 112 NSGAKIHCESKDGLTL---LHCAAQKGHVPVLAFIMEDLEDV-ALDHVDKLGRTAFHRAA 167

Query: 654 AYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713
            +G +DA+  L+    + +  D  G TALH     GH   +Q L++  + +  +++ G T
Sbjct: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLT 227

Query: 714 PLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK-CF 772
            LH AA   H   +  LL+   +      K+    + LH+A  +G+E+   VL+    C 
Sbjct: 228 ALHSAAGGSHPDCVQLLLRAGSTVNALTQKN---LSCLHYAALSGSEDVSRVLIHAGGCA 284

Query: 773 RKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQL 832
                   +PLH A+ ++      LL+ +   S V+  D++ +TPL  AA     +   +
Sbjct: 285 NVVDHQGASPLHLAVRHNFPALVRLLINS--DSDVNAVDNRQQTPLHLAAEHAWQDIADM 342

Query: 833 LLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
           LL     +N  D  GKTAL +A  +     VD+++ +
Sbjct: 343 LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score =  113 bits (282), Expect = 9e-25
 Identities = 73/264 (27%), Positives = 126/264 (47%), Gaps = 2/264 (0%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLI--LSGARVNAKDNMWLTPLHRAVA 58
           +L++    ++    +  T LH AA  G   ++  ++  L    ++  D +  T  HRA  
Sbjct: 109 ILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAE 168

Query: 59  SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
               +A+  L+    D N +DK   T LH+AA    +   + ++ +   +   +  G TA
Sbjct: 169 HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTA 228

Query: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
           LH AA   H + V LLL  G+ +NA  +K+   LH+AA  G  DV  +LI+ G      D
Sbjct: 229 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 288

Query: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
            +G +PLH A  +    +V+ L+N   +++ ++    T LH+A  +    + + L+  G 
Sbjct: 289 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGV 348

Query: 239 NVNQPNNNGFTPLHFAAASTHGAL 262
           ++N  +  G T L  A  S H +L
Sbjct: 349 DLNLRDKQGKTALAVAVRSNHVSL 372



 Score =  111 bits (278), Expect = 3e-24
 Identities = 110/407 (27%), Positives = 174/407 (42%), Gaps = 50/407 (12%)

Query: 311 DKDGNTPL----HVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
           + DG  PL    H AAR  +   +  L     +T          LH AA   H    R L
Sbjct: 8   ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLL 67

Query: 367 LSSGFEIDTPDK----------FGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
           L     +D  D           FG   L  +A  G++  +++L +SGA  H + K G T 
Sbjct: 68  LEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTL 127

Query: 417 LHYAAANCHFHCIETLVTTGANV--NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEE 474
           LH AA   H   +  ++    +V  +  D  GRTA H                       
Sbjct: 128 LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH----------------------- 164

Query: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
             RA E  + +A   L+FL+ +  + +++DKEG  ++H AA  GH   L+ L++      
Sbjct: 165 --RAAEHGQLDA---LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
           E++  G T   LH AA   H   +++LL++   ++   +K  + L  AA  G  +    L
Sbjct: 220 EQNAEGLTA--LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           I+ G    V D+    +PLH +V +     +RLL+    +  AVD +    QTPL LA  
Sbjct: 278 IHAGGCANVVDH-QGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ---QTPLHLAAE 333

Query: 655 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
           +   D   +LL    +++  D  G TAL   + + H   V M+++ +
Sbjct: 334 HAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380



 Score =  100 bits (250), Expect = 5e-21
 Identities = 69/235 (29%), Positives = 113/235 (48%), Gaps = 2/235 (0%)

Query: 2   LIHKTEDV--NTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59
           ++   EDV  + +D   RT  H AA  G  + ++ L+ SG   N KD    T LH A   
Sbjct: 143 IMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGR 202

Query: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
                +Q L+    D+  ++    T LH AA      C ++++   S+VN   +   + L
Sbjct: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 262

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
           H+AAL+G  ++  +L+  G   N  D +    LH A       +V LLIN  ++V   D 
Sbjct: 263 HYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDN 322

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
           +  TPLH AA +   ++   LL  GV+++  +  G TAL +A  +   ++V+ +I
Sbjct: 323 RQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 90/289 (31%), Positives = 131/289 (45%), Gaps = 24/289 (8%)

Query: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC----------TALHRGIMTGHEECV 694
           G+  L  A   GH  AV LLLE EA VD  D +G            AL      GH   +
Sbjct: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107

Query: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
           Q+L+     I C+   G T LH AA +GH   L+ +++  L +      D  G T  H A
Sbjct: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIME-DLEDVALDHVDKLGRTAFHRA 166

Query: 755 CYNGNENCIEVLLEQKC---FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSI-VSCR 810
             +G  + ++ L+   C    +   GN  T LH A    H    ++L   +D  + +  +
Sbjct: 167 AEHGQLDALDFLVGSGCDHNVKDKEGN--TALHLAAGRGH---MAVLQRLVDIGLDLEEQ 221

Query: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
           + +G T L +AA   H +C+QLLLR  + VNA+     + L  AA +G      +L++ A
Sbjct: 222 NAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH-A 280

Query: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919
                V D    +PLHLA    H   AL+ L  I  +S +N  +N  QT
Sbjct: 281 GGCANVVDHQGASPLHLAVR--HNFPALVRL-LINSDSDVNAVDNRQQT 326



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 45/135 (33%), Positives = 74/135 (54%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+     VN L  +  + LH AA  G  ++  +LI +G   N  D+   +PLH AV   
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
               V++LI   +DVNA D   QTPLH+AA +     A++++     +N+ D+ G+TAL 
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362

Query: 121 HAALNGHVEMVNLLL 135
            A  + HV +V++++
Sbjct: 363 VAVRSNHVSLVDMII 377



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 72/269 (26%), Positives = 108/269 (40%), Gaps = 71/269 (26%)

Query: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
           A    ++  +  L+ +  N    + +G  ALH     GHE+ V++LLE E ++  +D+ G
Sbjct: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81

Query: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-- 769
                                 AL+E   CF    G   L  + + G+   +++L+    
Sbjct: 82  ----------------------ALTEARLCF----GMNALLLSAWFGHLRILQILVNSGA 115

Query: 770 --KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
              C  K   +  T LHCA                          KG  P+ A    D  
Sbjct: 116 KIHCESK---DGLTLLHCAA------------------------QKGHVPVLAFIMED-- 146

Query: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887
                       ++ VD  G+TA   AAE+GQ  A+D LV S   D  VKDK+ NT LHL
Sbjct: 147 -------LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG-CDHNVKDKEGNTALHL 198

Query: 888 ACSKGHEKCALLILDKIQDESLINEKNNA 916
           A  +GH    + +L ++ D  L  E+ NA
Sbjct: 199 AAGRGH----MAVLQRLVDIGLDLEEQNA 223



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 25/70 (35%), Positives = 42/70 (60%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +LI+   DVN +D+ ++TPLH+AA     +I ++L+++G  +N +D    T L  AV S 
Sbjct: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSN 368

Query: 61  SEEAVQVLIK 70
               V ++IK
Sbjct: 369 HVSLVDMIIK 378


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  172 bits (436), Expect = 1e-42
 Identities = 111/339 (32%), Positives = 171/339 (50%), Gaps = 3/339 (0%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           M I + +DV+       + LH+A   G  E  + L+L+ A  N  +    TPLH AV  R
Sbjct: 423 MKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERR 482

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
               V++L+     VNA+D++  T LH AA N       +++   +SVN  D  GRT +H
Sbjct: 483 VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMH 542

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH-GAEVTCKDK 179
            A  +G   +V +LL +G +++   K     LH+AA+ GHL +V LL    G  V  +  
Sbjct: 543 VACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL 602

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
            G TPLH AA  G   V + L++L  +++  ++   T LH+A   G  +    L+  GA 
Sbjct: 603 DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
                ++G+T LH AA + H A  ++LLV   ADV  +    ++ LH+ A HG     + 
Sbjct: 663 KEAMTSDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721

Query: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
           L+ +   ID  D+ G + LH+AA+  H   + TL   GA
Sbjct: 722 LV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  166 bits (419), Expect = 1e-40
 Identities = 110/369 (29%), Positives = 172/369 (46%), Gaps = 3/369 (0%)

Query: 72  SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
           ++D+   D   +  +    +    K  +++ P    V+++   G + LH A   G  E  
Sbjct: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454

Query: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
             LL   AN N  +++    LH A       VV LL+     V  KD+  +T LH AA N
Sbjct: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514

Query: 192 GQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL 251
           G  +  + LL     ++E++  G T +H+AC +GQ+ +V  L+  G +V+    + + PL
Sbjct: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574

Query: 252 HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
           H+AA   H  +   L    G  VN Q+ DG++PLH+ A  G +  ++ LI    +++   
Sbjct: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634

Query: 312 KDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
               TPLHVAA  GH      L   GA            LHLAA N H    + L+    
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694

Query: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
           ++       +T LH AAA G+ E ++ L S+       D+ G + LH AA   H   +ET
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 432 LVTTGANVN 440
           L+  GA++N
Sbjct: 754 LLRHGAHIN 762



 Score =  144 bits (364), Expect = 3e-34
 Identities = 110/397 (27%), Positives = 178/397 (44%), Gaps = 41/397 (10%)

Query: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
           ++ T D   +  + A  +G   + +K+LQ    D       G + LH A       C + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKW 456

Query: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491
           L+   AN N ++  G T LH A                             E+     +E
Sbjct: 457 LLLNNANPNLSNRRGSTPLHMAV----------------------------ERRVRGVVE 488

Query: 492 FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAY 551
            LL    + + +D++ + ++H+AA  G      LLLE+  S  E    G T  P+H+A  
Sbjct: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT--PMHVACQ 546

Query: 552 NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDNVTKR 610
           +G    + +LL+  VD+ ++ +     L  AA++GH   V+ L   PG S+  +  +  R
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ-TLDGR 605

Query: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
           TPLH +   GH    R+L+++  +   V+V     QTPL +A   GH     LLL + A 
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSD---VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662

Query: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
            + +   G TALH     GH   V++L+E++  +L +    +T LH AAA GH    SE+
Sbjct: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH----SEV 718

Query: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
           ++  +S +     D QG + LH A    +   +E LL
Sbjct: 719 VEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755



 Score =  135 bits (339), Expect = 2e-31
 Identities = 116/363 (31%), Positives = 169/363 (46%), Gaps = 38/363 (10%)

Query: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
           ++D     G + LH A   G  EC K L  + A+ +  ++ G TPLH A        +E 
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491
           L+    +VN  D+   TALH+AA            N  ++S  L                
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQ-----------NGDESSTRL---------------- 522

Query: 492 FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAA 550
            LL+ +A+ +  D EG   +H A  +G    + +LL R   G + S  G     PLH AA
Sbjct: 523 -LLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR---GVDVSLQGKDAWLPLHYAA 578

Query: 551 YNGHHQALEVLL-QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
           + GH   +++L  Q  V ++ +   GRT L LAA +GH      LI+  + + V  ++  
Sbjct: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLA 637

Query: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
           +TPLH +   GHT   RLLL      EA+    + G T L LA   GH+  V LL+E++A
Sbjct: 638 QTPLHVAAETGHTSTARLLLHRGAGKEAM---TSDGYTALHLAARNGHLATVKLLVEEKA 694

Query: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
           +V     L  TALH     GH E V+ L+  +V  L  D +G + LH AA   HA  +  
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLF-DEQGLSALHLAAQGRHAQTVET 753

Query: 730 LLQ 732
           LL+
Sbjct: 754 LLR 756



 Score =  131 bits (330), Expect = 3e-30
 Identities = 104/363 (28%), Positives = 158/363 (43%), Gaps = 35/363 (9%)

Query: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
           G + LH+A   GQ+     L+   AN N  N  G TPLH A       + +ELL+     
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV-VELLLARKIS 496

Query: 274 VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
           VN + +D  + LH  A +G  + ++ L++    ++ VD +G TP+HVA ++G E ++  L
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556

Query: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS-GFEIDTPDKFGRTCLHAAAAGGN 392
              G D +  G  +  PLH AA   H    + L    G  ++     GRT LH AA  G+
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616

Query: 393 VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452
               ++L    +D +      +TPLH AA   H      L+  GA        G TALH 
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676

Query: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512
           AA            N H                    ++ L++  A+   R      ++H
Sbjct: 677 AAR-----------NGH-----------------LATVKLLVEEKADVLARGPLNQTALH 708

Query: 513 YAAAYGHRQCLELLLERTNSG-FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
            AAA+GH + +E L+       F+E    A    LHLAA   H Q +E LL+    ++++
Sbjct: 709 LAAAHGHSEVVEELVSADVIDLFDEQGLSA----LHLAAQGRHAQTVETLLRHGAHINLQ 764

Query: 572 DEK 574
             K
Sbjct: 765 SLK 767



 Score =  123 bits (309), Expect = 7e-28
 Identities = 103/348 (29%), Positives = 151/348 (43%), Gaps = 31/348 (8%)

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G + LH A   GQ    K LL      +  N  G+T LH+A       VV  L+    +V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  + + +T LHFAA +   +    LL+   A VN    +G++P+H+   HG+    + L
Sbjct: 498 NAKDEDQWTALHFAAQNGDES-STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTL-RTSGADTAKCGIHSMFPLHLAALNAH 359
           ++ G ++    KD   PLH AA  GH  ++  L +  G       +    PLHLAA   H
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616

Query: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
               R L+    +++      +T LH AA  G+    +LL   GA        G T LH 
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676

Query: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479
           AA N H   ++ LV   A+V       +TALH AA             AH +SE +E   
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQTALHLAA-------------AHGHSEVVE--- 720

Query: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
           EL   +                + D++G +++H AA   H Q +E LL
Sbjct: 721 ELVSADVI-------------DLFDEQGLSALHLAAQGRHAQTVETLL 755



 Score =  119 bits (297), Expect = 2e-26
 Identities = 115/385 (29%), Positives = 161/385 (41%), Gaps = 50/385 (12%)

Query: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
           +A+  R  L L  ER  S  +   +   K  L  A  +G    L  +LQ   D+D+  + 
Sbjct: 379 SAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDS 437

Query: 575 GRTALDLAAFKGHTECVEALI----NPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
           G + L LA   G  EC + L+    NP  S     N    TPLH +V       + LLL 
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLS-----NRRGSTPLHMAVERRVRGVVELLLA 492

Query: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
                 +V+ KD    T L  A   G   +  LLLEK A+V+ VD  G T +H     G 
Sbjct: 493 ---RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
           E  V++LL + V +  +      PLHYAA +GH   +  L +      +    D  G TP
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD--GRTP 607

Query: 751 LHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCR 810
           LH A   G+     +L++                C+ +N      SLL            
Sbjct: 608 LHLAAQRGHYRVARILIDL---------------CSDVN----VCSLL------------ 636

Query: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
               +TPL  AA   H    +LLL   A   A+ + G TAL +AA NG    V +LV   
Sbjct: 637 ---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE- 692

Query: 871 QADLTVKDKDLNTPLHLACSKGHEK 895
           +AD+  +     T LHLA + GH +
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSE 717



 Score =  117 bits (294), Expect = 4e-26
 Identities = 106/349 (30%), Positives = 156/349 (44%), Gaps = 38/349 (10%)

Query: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
           G + +H A   G  +C + LL    +    +  G+T  PLH+A        +E+LL   +
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGST--PLHMAVERRVRGVVELLLARKI 495

Query: 567 DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLR 626
            ++ +DE   TAL  AA  G       L+   AS+   D    RTP+H +  +G    +R
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD-FEGRTPMHVACQHGQENIVR 554

Query: 627 LLLEIADNPEAVDV----KDAKGQTPLMLAVAYGHIDAVSLLLEK---EANVDTVDILGC 679
           +LL        VDV    KDA    PL  A   GH+  V LL ++     N  T+D  G 
Sbjct: 555 ILLR-----RGVDVSLQGKDA--WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD--GR 605

Query: 680 TALHRGIMTGHEECVQMLLEQEVSILCKDSR-----GRTPLHYAAARGHATWLSELLQMA 734
           T LH     GH    ++L++     LC D        +TPLH AA  GH +    LL   
Sbjct: 606 TPLHLAAQRGHYRVARILID-----LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660

Query: 735 LSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHG 792
             +E      + GYT LH A  NG+   +++L+E+K      G P   T LH A  + H 
Sbjct: 661 AGKEAMT---SDGYTALHLAARNGHLATVKLLVEEKADVLARG-PLNQTALHLAAAHGHS 716

Query: 793 NCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
                L+ A    ++   D++G + L  AA   H + ++ LLRH A +N
Sbjct: 717 EVVEELVSA---DVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  105 bits (263), Expect = 1e-22
 Identities = 92/311 (29%), Positives = 140/311 (45%), Gaps = 11/311 (3%)

Query: 597 PGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYG 656
           P  S     +V K+  + A +++G T  L  +L+    P+ VD+    G + L LAV  G
Sbjct: 395 PSTSDLGTTDVQKKKLVDA-IVSGDTSKLMKILQ----PQDVDLALDSGASLLHLAVEAG 449

Query: 657 HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716
             +    LL   AN +  +  G T LH  +       V++LL +++S+  KD    T LH
Sbjct: 450 QEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALH 509

Query: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776
           +AA  G  +    LL+   S  +    D +G TP+H AC +G EN + +LL +       
Sbjct: 510 FAAQNGDESSTRLLLEKNASVNEV---DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ 566

Query: 777 G-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
           G + + PLH A    H     LL      S V+ +   GRTPL  AA   H    ++L+ 
Sbjct: 567 GKDAWLPLHYAAWQGHLPIVKLLAKQPGVS-VNAQTLDGRTPLHLAAQRGHYRVARILID 625

Query: 836 HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
             + VN      +T L +AAE G      +L++   A       D  T LHLA   GH  
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLA 684

Query: 896 CALLILDKIQD 906
              L++++  D
Sbjct: 685 TVKLLVEEKAD 695



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 90/369 (24%), Positives = 148/369 (40%), Gaps = 38/369 (10%)

Query: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
           ++D     G + LH+A   G E     L  + A+          PLH+A           
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
           LL+    ++  D+   T LH AA  G+    +LL    A  ++ D  GRTP+H A  +  
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
            + +  L+  G +V+         LHYAA                              +
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAA-----------------------------WQ 580

Query: 486 ATLCLEFLLQNDANPSIRDK--EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK 543
             L +  LL      S+  +  +G   +H AA  GH +   +L++  +       S   +
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD--VNVCSLLAQ 638

Query: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
           +PLH+AA  GH     +LL      +     G TAL LAA  GH   V+ L+   A +  
Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698

Query: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
           +  +  +T LH +  +GH+  +  L+    + + +D+ D +G + L LA    H   V  
Sbjct: 699 RGPL-NQTALHLAAAHGHSEVVEELV----SADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 664 LLEKEANVD 672
           LL   A+++
Sbjct: 754 LLRHGAHIN 762



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 71/246 (28%), Positives = 99/246 (40%), Gaps = 66/246 (26%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ K   VN +D E RTP+HVA   G   I+ +L+  G  V+ +      PLH A    
Sbjct: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG 581

Query: 61  SEEAVQVLIKH-SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD------- 112
               V++L K     VNA+  + +TPLH+AA     + A ++I L S VNV         
Sbjct: 582 HLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPL 641

Query: 113 -----------------RG---------GRTALHHAALNGHVEMVNLLLAKGANINA--- 143
                            RG         G TALH AA NGH+  V LL+ + A++ A   
Sbjct: 642 HVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGP 701

Query: 144 -----------------------------FDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
                                        FD++   ALH AA   H   V  L+ HGA +
Sbjct: 702 LNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761

Query: 175 TCKDKK 180
             +  K
Sbjct: 762 NLQSLK 767



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 783 LHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNA 842
           LH A+      CA  LL  ++++  +  + +G TPL  A        ++LLL     VNA
Sbjct: 442 LHLAVEAGQEECAKWLL--LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNA 499

Query: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
            D    TAL  AA+NG   +  +L+    A +   D +  TP+H+AC  G E    ++L 
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLR 558

Query: 903 KIQDESL 909
           +  D SL
Sbjct: 559 RGVDVSL 565



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 1/83 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+ +  DV       +T LH+AA  G +E++E L+ S   ++  D   L+ LH A   R
Sbjct: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGR 746

Query: 61  SEEAVQVLIKHSADVNARDKNWQ 83
             + V+ L++H A +N +   +Q
Sbjct: 747 HAQTVETLLRHGAHINLQSLKFQ 769


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  170 bits (431), Expect = 5e-42
 Identities = 158/600 (26%), Positives = 256/600 (42%), Gaps = 80/600 (13%)

Query: 119 LHHAALNGHVEMVNLLLAKGAN--INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
           LH+AA  G +E++  +    +   ++  D      LH A     ++ V  L++ GA    
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 177 KDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
           ++     PLH A       V+K LL +  ++++     GNTA+ IAC       +  L+ 
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 236 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD--------VNIQSKDGKSPLHM 287
            GA   + N  G  P+H AA S     C+E+++  G +        +N  +    +PLH+
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKE-CMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245

Query: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347
              +G     +  + NG +ID V+K   T +H AA  G   ++  + +S + +       
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI---- 301

Query: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
                                    ++T D    T LH A+   + E    L S GAD +
Sbjct: 302 -------------------------VNTTDGCHETMLHRASLFDHHELADYLISVGADIN 336

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
           K D  GR+PL  A A+  ++ +  L++ GA V+  D++GR  LH             L N
Sbjct: 337 KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYG-----LKN 391

Query: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
                 ++++ +EL   E                  D +G   +HYA   G    +  LL
Sbjct: 392 LRPEFMQMQQIKELVMDE------------------DNDGCTPLHYACRQGGPGSVNNLL 433

Query: 528 ERTNSGFE---ESDSGATKSPLHLAAYNGHHQALEVLLQSLVD---LDIRDEKGRTALDL 581
                GF     S S   KSPLH AA  G     + LLQ + D   L+  D  G T L L
Sbjct: 434 -----GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488

Query: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
           AA  GH + V+ L+  GA +F+ D+    T LH + + G+T  ++++L+   N +  D  
Sbjct: 489 AAKNGHDKVVQLLLKKGA-LFLSDH-NGWTALHHASMGGYTQTMKVILD--TNLKCTDRL 544

Query: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
           D  G T L  A   GH  AV+LLL   A++  ++    + LH  +    +E V  ++  +
Sbjct: 545 DEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTIIRSK 603



 Score =  166 bits (420), Expect = 9e-41
 Identities = 131/473 (27%), Positives = 224/473 (47%), Gaps = 30/473 (6%)

Query: 7   EDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
           E ++ +D    TPLH A      E ++ L+  GA  N ++   + PLH AV   + E ++
Sbjct: 89  EVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMK 148

Query: 67  VLIKH-SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALN 125
           VL++H + DVN   +N  T + +A      +  ++++   +    S++ G   +H AA +
Sbjct: 149 VLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFS 208

Query: 126 GHVEMVNLLLAKG--------ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
           G  E + ++L  G         +IN  +      LH A   G L+++ + +++GA++   
Sbjct: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268

Query: 178 DKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYG---NTALHIACYNGQDAVVNEL 233
           +K   T +H AA+ G   +VK ++ +    +D +N       T LH A       + + L
Sbjct: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328

Query: 234 IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA---- 289
           I  GA++N+ ++ G +PL  A AS    + + LL++ GA V+I+   G++ LH+T     
Sbjct: 329 ISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387

Query: 290 ----VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGI 345
               +   F + Q + +    +   D DG TPLH A R G    +N L            
Sbjct: 388 GLKNLRPEFMQMQQIKE---LVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444

Query: 346 HSMFPLHLAALNAHSDCCRKLL---SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
               PLH AA     + C++LL   S    ++  D  G T LH AA  G+ + ++LL   
Sbjct: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504

Query: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAA 454
           GA F   D  G T LH+A+   +   ++ ++ T     +  D+ G TALH+AA
Sbjct: 505 GALF-LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA 556



 Score =  164 bits (415), Expect = 4e-40
 Identities = 126/461 (27%), Positives = 221/461 (47%), Gaps = 38/461 (8%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVAS 59
           +L H+T DVN       T + +A    ++E +++L+  GA+   K N W   P+H+A  S
Sbjct: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK-PCKSNKWGCFPIHQAAFS 208

Query: 60  RSEEAVQVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS 111
            S+E ++++++   +        +N  +    TPLH+A  N  ++  ++ +   + ++  
Sbjct: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268

Query: 112 DRGGRTALHHAALNGHVEMVNLLLAKGAN----INAFDKKDRRALHWAAYMGHLDVVALL 167
           ++G  TA+H AA  G  E+V L+++  +     +N  D      LH A+   H ++   L
Sbjct: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328

Query: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG-- 225
           I+ GA++   D +G +PL  A ++   N+V  LL+ G ++D  + +G   LH+       
Sbjct: 329 ISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYG 388

Query: 226 ---------QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI 276
                    Q   + EL      V   +N+G TPLH+A     G   +  L+     ++ 
Sbjct: 389 LKNLRPEFMQMQQIKEL------VMDEDNDGCTPLHYACRQ-GGPGSVNNLLGFNVSIHS 441

Query: 277 QSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTL 333
           +SKD KSPLH  A +GR    Q L+Q+  +   +   D  G TPLH+AA+ GH+ ++  L
Sbjct: 442 KSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501

Query: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGRTCLHAAAAGGN 392
              GA       +    LH A++  ++   + +L +  +  D  D+ G T LH AA  G+
Sbjct: 502 LKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGH 560

Query: 393 VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
            + + LL S  AD    +K   + LH A  N     + T++
Sbjct: 561 AKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTII 600



 Score =  152 bits (385), Expect = 1e-36
 Identities = 165/583 (28%), Positives = 249/583 (42%), Gaps = 85/583 (14%)

Query: 342 KCGIHSMFPLHLAALNAHSDCCRKLL--SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
           +C     F LH AA     +   K+   SS   +   D +G T LH A     +E +K L
Sbjct: 58  RCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117

Query: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA-NVNETDDWGRTALHYAAASDM 458
            S GA+ + ++     PLH A    +   ++ L+     +VN   + G TA+  A  ++ 
Sbjct: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTN- 176

Query: 459 DRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYG 518
                       NSE                L+ LL+  A P   +K G   IH AA  G
Sbjct: 177 ------------NSE---------------ALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209

Query: 519 HRQCLELLLE-RTNSGFEES-----DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
            ++C+E++L      G+         +    +PLHLA  NG  + +++ L +   +D   
Sbjct: 210 SKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQID-PV 268

Query: 573 EKGR-TALDLAAFKGHTECVEALINPGASIFVKDNVTK---RTPLH-ASVINGHTLCLRL 627
           EKGR TA+  AA +G TE V+ +I+  +      N T     T LH AS+ + H L   L
Sbjct: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328

Query: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIM 687
           +   AD    ++  D++G++PL+LA A    + V+LLL K A VD               
Sbjct: 329 ISVGAD----INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI-------------- 370

Query: 688 TGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR--GHATWLSELLQMALSEEDCCFKDN 745
                              KD+ GR  LH    +  G      E +QM   +E    +DN
Sbjct: 371 -------------------KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411

Query: 746 QGYTPLHWACYNGNENCIEVLLE-QKCFRKFIGNPFTPLHCAIINDHGN-CASLLLGAID 803
            G TPLH+AC  G    +  LL           +  +PLH A      N C  LL    D
Sbjct: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
           + +++  D  G TPL  AA   H + +QLLL+  A +   D++G TAL  A+  G    +
Sbjct: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906
            +++++        D+D NT LH A  +GH K   L+L    D
Sbjct: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573



 Score =  147 bits (370), Expect = 6e-35
 Identities = 149/558 (26%), Positives = 244/558 (43%), Gaps = 58/558 (10%)

Query: 86  LHVAAANKAVKCAEVII--PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
           LH AAA   ++  E I     L  ++  D  G T LH A     +E V  LL++GAN N 
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 144 FDKKDRRALHWAAYMGHLDVVALLINHGA-EVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
            +      LH A    + +V+ +L+ H   +V  + + G T +  A +      ++ LL 
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYG--------ANVNQPNNNGFTPLHFA 254
            G +  + N +G   +H A ++G    +  ++ +G         ++N  NN   TPLH A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 255 AASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN-GGEIDCVD- 311
               +G L  +++ ++NGA ++   K   + +H  A  G     + +I +  G +D V+ 
Sbjct: 247 V--QNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304

Query: 312 KDG--NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
            DG   T LH A+ + H  L + L + GAD  K       PL LA  +A  +    LLS 
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364

Query: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK-------KDKCGRTPLHYAAA 422
           G ++D  D FGR  LH          +K L+       +       +D  G TPLHYA  
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQ--QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACR 422

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
                 +  L+    +++      ++ LH+AA+         +       +++   R L 
Sbjct: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR------INTCQRLLQDISDTRLLN 476

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
           E                    D  G   +H AA  GH + ++LLL++  + F    +G T
Sbjct: 477 E-------------------GDLHGMTPLHLAAKNGHDKVVQLLLKK-GALFLSDHNGWT 516

Query: 543 KSPLHLAAYNGHHQALEVLLQ-SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
              LH A+  G+ Q ++V+L  +L   D  DE G TAL  AA +GH + V  L++  A I
Sbjct: 517 --ALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI 574

Query: 602 FVKDNVTKRTPLHASVIN 619
            +  N  + + LH ++ N
Sbjct: 575 VL--NKQQASFLHLALHN 590



 Score =  102 bits (254), Expect = 2e-21
 Identities = 123/529 (23%), Positives = 208/529 (39%), Gaps = 121/529 (22%)

Query: 405 DFHKKDKCGRTP------LHYAAANCHFHCIETLVTTGAN--VNETDDWGRTALHYAAAS 456
           +F+K+ K  R        LHYAAA      +E +    +   ++E DD+G T LH A   
Sbjct: 49  NFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAV-- 106

Query: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
                                     EK     ++FLL   ANP++R+   +N +     
Sbjct: 107 --------------------------EKNQIESVKFLLSRGANPNLRN---FNMM----- 132

Query: 517 YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS-LVDLDIRDEKG 575
                                      +PLH+A    +++ ++VLL+   +D+++  E G
Sbjct: 133 ---------------------------APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENG 165

Query: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635
            TA+ +A    ++E ++ L+  GA    K N     P+H +  +G   C+ ++L   +  
Sbjct: 166 NTAVIIACTTNNSEALQILLKKGAKP-CKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224

Query: 636 EA-----VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
                  ++  +    TPL LAV  G ++ + + L+  A +D V+   CTA+H     G 
Sbjct: 225 GYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284

Query: 691 EECVQMLLEQ---EVSIL-CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ 746
            E V++++      V I+   D    T LH A+   H      L+ +     D    D++
Sbjct: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGA---DINKIDSE 341

Query: 747 GYTPLHWACYNGNENCIEVLLE---QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAID 803
           G +PL  A  + + N + +LL    Q   +   G  F  LH  +   +G           
Sbjct: 342 GRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNF--LHLTVQQPYG----------- 388

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
             + + R +          F    +  +L++         DN G T L  A   G  G+V
Sbjct: 389 --LKNLRPE----------FMQMQQIKELVMDE-------DNDGCTPLHYACRQGGPGSV 429

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
           + L+      +  K KD  +PLH A S G       +L  I D  L+NE
Sbjct: 430 NNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477



 Score =  102 bits (253), Expect = 2e-21
 Identities = 94/312 (30%), Positives = 147/312 (47%), Gaps = 14/312 (4%)

Query: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
           VNT D    T LH A+     E+ + LI  GA +N  D+   +PL  A AS S   V +L
Sbjct: 302 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361

Query: 69  IKHSADVNARDKNWQTPLHVAAAN----KAVKCAEVIIPLLSS-VNVSDRGGRTALHHAA 123
           +   A V+ +D   +  LH+        K ++   + +  +   V   D  G T LH+A 
Sbjct: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421

Query: 124 LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC---KDKK 180
             G    VN LL    +I++  K  +  LH+AA  G ++    L+   ++       D  
Sbjct: 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 481

Query: 181 GYTPLHAAASNGQINVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
           G TPLH AA NG   VV+ LL  G + + + N  G TALH A   G    +  ++D    
Sbjct: 482 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN--GWTALHHASMGGYTQTMKVILDTNLK 539

Query: 240 -VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
             ++ + +G T LHFAA   H A  + LL+++ AD+ + +K   S LH+   + R     
Sbjct: 540 CTDRLDEDGNTALHFAAREGH-AKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVL 597

Query: 299 TLIQNGGEIDCV 310
           T+I++    +C+
Sbjct: 598 TIIRSKRWDECL 609


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  167 bits (424), Expect = 3e-41
 Identities = 135/461 (29%), Positives = 225/461 (48%), Gaps = 30/461 (6%)

Query: 8   DVNTLDSEKRTPLHV---AAFLGDAEIIELLILSGA-----------RVNAKDN-----M 48
           D+ T+D E +  L     AA   D E++  L  S +           R+ A+++     +
Sbjct: 134 DLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 193

Query: 49  WLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV 108
               L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HA 251

Query: 109 NVSDRGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165
           NV DRG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V 
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311

Query: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYN 224
           +L+N GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY 
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371

Query: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
           G   +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SP
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESP 430

Query: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKC 343
           L + A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+ 
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490

Query: 344 GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403
                  L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SG
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547

Query: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
           A+ H     G T L YA  N H    + L+  GA++++ +D
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588



 Score =  127 bits (319), Expect = 5e-29
 Identities = 123/420 (29%), Positives = 177/420 (42%), Gaps = 37/420 (8%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315

Query: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
              H      L+  GAN+ E +D G T L                        +E ARE 
Sbjct: 436 CGGHVELAALLIERGANLEEVNDEGYTPL------------------------MEAAREG 471

Query: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
            E+   L    LL   AN + + +E   +    A  G    +   L +  +  E   S  
Sbjct: 472 HEEMVAL----LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-- 525

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
             +PL  A+  GH + ++ LL S  ++      G TAL  A   GHT+  + L+  GA +
Sbjct: 526 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score =  122 bits (305), Expect = 2e-27
 Identities = 114/397 (28%), Positives = 180/397 (45%), Gaps = 20/397 (5%)

Query: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
           LL    + +   +EG + +  A + G+ +  ++LL   ++  E+  +    +PL  A+  
Sbjct: 213 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVEDRGNKGDITPLMAASSG 271

Query: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612
           G+   +++LL    D++ +   G TAL  A   G  + V+ L+N GA+I    N    TP
Sbjct: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI-EDHNENGHTP 330

Query: 613 LHASVINGHTLCLRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
           L  +   GH    R+LL+     N  + + K++     L LA   GH+D V  LLE  A+
Sbjct: 331 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESA----LTLACYKGHLDMVRFLLEAGAD 386

Query: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
            +       TAL    M GH E  ++LL+    +        +PL  AA  GH    + L
Sbjct: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446

Query: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAII 788
           ++   + E+    +++GYTPL  A   G+E  + +LL Q      +      T L  A  
Sbjct: 447 IERGANLEEV---NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 503

Query: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
                 A  L+ A     + C      TPL  A+   H+E ++ LL   A V+A   +G 
Sbjct: 504 GGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGD 558

Query: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
           TAL  A ENG     D+L+  A ADL  K +D+ T L
Sbjct: 559 TALTYACENGHTDVADVLL-QAGADLD-KQEDMKTIL 593



 Score =  114 bits (285), Expect = 4e-25
 Identities = 91/310 (29%), Positives = 147/310 (47%), Gaps = 7/310 (2%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 280 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338

Query: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 519 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 574

Query: 299 TLIQNGGEID 308
            L+Q G ++D
Sbjct: 575 VLLQAGADLD 584



 Score =  107 bits (268), Expect = 4e-23
 Identities = 78/244 (31%), Positives = 125/244 (51%), Gaps = 5/244 (2%)

Query: 1   MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59
           +L+     +NT  +E K + L +A + G  +++  L+ +GA    K +   T L  A   
Sbjct: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404

Query: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
              E  ++L+   A VN    ++++PL +AA    V+ A ++I   +++   +  G T L
Sbjct: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 464

Query: 120 HHAALNGHVEMVNLLLAKGANINA-FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
             AA  GH EMV LLLA+GANINA  ++    AL  A   G  +V   LI  GA++   +
Sbjct: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---E 521

Query: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
               TPL  A+  G + +VK+LL  G  +      G+TAL  AC NG   V + L+  GA
Sbjct: 522 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581

Query: 239 NVNQ 242
           ++++
Sbjct: 582 DLDK 585



 Score =  104 bits (259), Expect = 4e-22
 Identities = 105/409 (25%), Positives = 175/409 (42%), Gaps = 47/409 (11%)

Query: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238

Query: 458 MDRNKTILGNAHDNSEELERARELKEKEATL------CLEFLLQNDANPSIRDKEGYNSI 511
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298

Query: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 356

Query: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 414

Query: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 415 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 472

Query: 691 EECVQMLLEQEVSILCKDSRGR-------------------------------TPLHYAA 719
           EE V +LL Q  +I  +    +                               TPL  A+
Sbjct: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 532

Query: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
             GH   +  LL    S  +       G T L +AC NG+ +  +VLL+
Sbjct: 533 QEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVLLQ 578



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 107/388 (27%), Positives = 169/388 (43%), Gaps = 33/388 (8%)

Query: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
           AAA+   + L  L    +   +E+ +  T+    + A N H+ A +V  +SL +      
Sbjct: 152 AAAFADPEVLRRLTSSVSCALDEAAAALTR----MKAENSHN-AGQVDTRSLAE------ 200

Query: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
                   A   G    V  L++ G S+  +      + L  +   G+    ++LL +  
Sbjct: 201 --------ACSDGDVNAVRKLLDEGRSVN-EHTEEGESLLCLACSAGYYELAQVLLAMHA 251

Query: 634 NPEAVDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
           N   V+ +  KG  TPLM A + G++D V LLL  +A+V++    G TAL      G  +
Sbjct: 252 N---VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308

Query: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ--MALSEEDCCFKDNQGYTP 750
            V++LL +  +I   +  G TPL  AA+ GH      LL     ++     FK+    + 
Sbjct: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SA 364

Query: 751 LHWACYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSC 809
           L  ACY G+ + +  LLE    ++       T L  A ++ H   A LLL +   + V+ 
Sbjct: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS--GAQVNM 422

Query: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
             D   +PL  AA   HVE   LL+   A +  V++ G T LM AA  G    V +L+  
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482

Query: 870 AQADLTVKDKDLNTPLHLACSKGHEKCA 897
                   ++   T L LAC  G  + A
Sbjct: 483 GANINAQTEETQETALTLACCGGFSEVA 510



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 77/275 (28%), Positives = 121/275 (44%), Gaps = 9/275 (3%)

Query: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 212 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 271

Query: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 328

Query: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSI 806
           TPL  A   G+     VLL+         N F  + L  A    H +    LL A   + 
Sbjct: 329 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA--GAD 386

Query: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
              + D+  T L  A    HVE  +LLL   A VN   +S ++ L +AA  G      +L
Sbjct: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446

Query: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
           +    A+L   + +  TPL  A  +GHE+   L+L
Sbjct: 447 IERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLL 480



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 87/316 (27%), Positives = 137/316 (43%), Gaps = 50/316 (15%)

Query: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           +EAL+   A+ F    V +R  + +  ++        R+  E + N   VD +       
Sbjct: 146 LEALLE--AAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS------ 197

Query: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
           L  A + G ++AV  LL++  +V+     G + L      G+ E  Q+LL    ++  + 
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 709 SRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
           ++G  TPL  A++ G+   +  LL   L + D   +   G T L +AC  G  + ++VLL
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314

Query: 768 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
            +                A I DH                   ++ G TPL  AA A HV
Sbjct: 315 NEG---------------ANIEDH-------------------NENGHTPLMEAASAGHV 340

Query: 828 ECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886
           E  ++LL H A +N   N  K +AL +A   G    V  L+  A AD   K  +++T L 
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALM 399

Query: 887 LACSKGHEKCALLILD 902
            AC  GH + A L+LD
Sbjct: 400 EACMDGHVEVARLLLD 415



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL      +  GN    TPL  A    + +   LLL  + 
Sbjct: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL--LH 283

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A     V+ +++LL   A +   + +G T LM AA  G     
Sbjct: 284 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L++      T  ++   + L LAC KGH      +L+   D E   +E + AL
Sbjct: 344 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 4/94 (4%)

Query: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNS 869
           ++G + L  A  A + E  Q+LL   A V    N G    +MAA +G  G +DI  L+  
Sbjct: 225 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG--GYLDIVKLLLL 282

Query: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
             AD+  +    NT L  AC+ G      ++L++
Sbjct: 283 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  167 bits (422), Expect = 5e-41
 Identities = 122/397 (30%), Positives = 201/397 (50%), Gaps = 11/397 (2%)

Query: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
           L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    NV D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266

Query: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
           RG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V +L+N
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228
            GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY G   
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
           +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SPL + 
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445

Query: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347
           A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+     
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
              L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SGA+ H
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
                G T L YA  N H    + L+  GA++++ +D
Sbjct: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score =  148 bits (374), Expect = 2e-35
 Identities = 114/376 (30%), Positives = 185/376 (49%), Gaps = 7/376 (1%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60
           L+ +   VN    E  + L +A   G  E+ ++L+   A V  + N   +TPL  A +  
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
             + V++L+ H ADVN++     T L  A A   V   +V++   +++   +  G T L 
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179
            AA  GHVE+  +LL  GA IN    + +  AL  A Y GHLD+V  L+  GA+   K  
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
           + +T L  A  +G + V + LL+ G +++       + L +A   G   +   LI+ GAN
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463

Query: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298
           + + N+ G+TPL  AA   H  + + LL+  GA++N Q+++ +      A  G F+  + 
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
            LI+ G +I+      +TPL  A++ GH  L+  L  SGA+           L  A  N 
Sbjct: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579

Query: 359 HSDCCRKLLSSGFEID 374
           H+D    LL +G ++D
Sbjct: 580 HTDVADVLLQAGADLD 595



 Score =  137 bits (345), Expect = 5e-32
 Identities = 120/416 (28%), Positives = 185/416 (44%), Gaps = 39/416 (9%)

Query: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
           +L  A  +G V  V  LL +G ++N   ++    L  A   G+ ++  +L+   A V  +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
             KG  TPL AA+S G +++VK LL    +++  +  GNTAL  AC  G   +V  L++ 
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
           GAN+   N NG TPL  AA++ H  +   +L+++GA +N  S + K              
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFK-------------- 372

Query: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
                              + L +A   GH  ++  L  +GAD           L  A +
Sbjct: 373 ------------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
           + H +  R LL SG +++ P     + L  AA GG+VE   LL   GA+  + +  G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474

Query: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
           L  AA   H   +  L+  GAN+N +T++   TAL  A           L  A  +  EL
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI-EL 533

Query: 476 ERARELKEKEATLCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
             +  L E      LE   +LL + AN       G  ++ YA   GH    ++LL+
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589



 Score =  136 bits (342), Expect = 1e-31
 Identities = 112/387 (28%), Positives = 182/387 (47%), Gaps = 7/387 (1%)

Query: 27  GDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR-DKNWQTP 85
           GD   +  L+  G  VN       + L  A ++   E  QVL+   A+V  R +K   TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 86  LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
           L  A++   +   ++++   + VN     G TAL +A   G V++V +LL +GANI   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 146 KKDRRALHWAAYMGHLDVVALLINHGAEV-TCKDKKGYTPLHAAASNGQINVVKHLLNLG 204
           +     L  AA  GH++V  +L++HGA + T  ++   + L  A   G +++V+ LL  G
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 205 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCL 264
            + +      +TAL  AC +G   V   L+D GA VN P ++  +PL  AA   H  L  
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA- 454

Query: 265 ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC-VDKDGNTPLHVAAR 323
            LL+  GA++   + +G +PL   A  G       L+  G  I+   ++   T L +A  
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514

Query: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
            G   + + L  +GAD     +    PL  A+   H +  + LL+SG  +      G T 
Sbjct: 515 GGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571

Query: 384 LHAAAAGGNVECIKLLQSSGADFHKKD 410
           L  A   G+ +   +L  +GAD  K++
Sbjct: 572 LTYACENGHTDVADVLLQAGADLDKQE 598



 Score =  127 bits (319), Expect = 5e-29
 Identities = 123/420 (29%), Positives = 177/420 (42%), Gaps = 37/420 (8%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
              H      L+  GAN+ E +D G T L                        +E ARE 
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPL------------------------MEAAREG 482

Query: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
            E+   L    LL   AN + + +E   +    A  G    +   L +  +  E   S  
Sbjct: 483 HEEMVAL----LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-- 536

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
             +PL  A+  GH + ++ LL S  ++      G TAL  A   GHT+  + L+  GA +
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score =  126 bits (317), Expect = 8e-29
 Identities = 97/327 (29%), Positives = 154/327 (47%), Gaps = 6/327 (1%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           TPL  A+  G  +I++LL+L  A VN++     T L  A A    + V+VL+   A++  
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136
            ++N  TPL  AA+   V+ A V++   + +N  S+    +AL  A   GH++MV  LL 
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
            GA+      +   AL  A   GH++V  LL++ GA+V        +PL  AA  G + +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255
              L+  G  ++E+N  G T L  A   G + +V  L+  GAN+N Q      T L  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
                 +  + L+  GAD+ +      +PL   +  G     + L+ +G  +      G+
Sbjct: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 316 TPLHVAARYGHELLINTLRTSGADTAK 342
           T L  A   GH  + + L  +GAD  K
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLDK 596



 Score =  122 bits (305), Expect = 2e-27
 Identities = 114/397 (28%), Positives = 180/397 (45%), Gaps = 20/397 (5%)

Query: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
           LL    + +   +EG + +  A + G+ +  ++LL   ++  E+  +    +PL  A+  
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVEDRGNKGDITPLMAASSG 282

Query: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612
           G+   +++LL    D++ +   G TAL  A   G  + V+ L+N GA+I    N    TP
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI-EDHNENGHTP 341

Query: 613 LHASVINGHTLCLRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
           L  +   GH    R+LL+     N  + + K++     L LA   GH+D V  LLE  A+
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESA----LTLACYKGHLDMVRFLLEAGAD 397

Query: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
            +       TAL    M GH E  ++LL+    +        +PL  AA  GH    + L
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAII 788
           ++   + E+    +++GYTPL  A   G+E  + +LL Q      +      T L  A  
Sbjct: 458 IERGANLEEV---NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514

Query: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
                 A  L+ A     + C      TPL  A+   H+E ++ LL   A V+A   +G 
Sbjct: 515 GGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
           TAL  A ENG     D+L+  A ADL  K +D+ T L
Sbjct: 570 TALTYACENGHTDVADVLL-QAGADLD-KQEDMKTIL 604



 Score =  114 bits (285), Expect = 4e-25
 Identities = 91/310 (29%), Positives = 147/310 (47%), Gaps = 7/310 (2%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585

Query: 299 TLIQNGGEID 308
            L+Q G ++D
Sbjct: 586 VLLQAGADLD 595



 Score =  107 bits (268), Expect = 4e-23
 Identities = 78/244 (31%), Positives = 125/244 (51%), Gaps = 5/244 (2%)

Query: 1   MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59
           +L+     +NT  +E K + L +A + G  +++  L+ +GA    K +   T L  A   
Sbjct: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415

Query: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
              E  ++L+   A VN    ++++PL +AA    V+ A ++I   +++   +  G T L
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475

Query: 120 HHAALNGHVEMVNLLLAKGANINA-FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
             AA  GH EMV LLLA+GANINA  ++    AL  A   G  +V   LI  GA++   +
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---E 532

Query: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
               TPL  A+  G + +VK+LL  G  +      G+TAL  AC NG   V + L+  GA
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592

Query: 239 NVNQ 242
           ++++
Sbjct: 593 DLDK 596



 Score =  104 bits (259), Expect = 4e-22
 Identities = 105/409 (25%), Positives = 175/409 (42%), Gaps = 47/409 (11%)

Query: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249

Query: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367

Query: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425

Query: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 691 EECVQMLLEQEVSILCKDSRGR-------------------------------TPLHYAA 719
           EE V +LL Q  +I  +    +                               TPL  A+
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 543

Query: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
             GH   +  LL    S  +       G T L +AC NG+ +  +VLL+
Sbjct: 544 QEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVLLQ 589



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 82/264 (31%), Positives = 122/264 (46%), Gaps = 10/264 (3%)

Query: 638 VDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQM 696
           V+ +  KG  TPLM A + G++D V LLL  +A+V++    G TAL      G  + V++
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 697 LLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ--MALSEEDCCFKDNQGYTPLHWA 754
           LL +  +I   +  G TPL  AA+ GH      LL     ++     FK+    + L  A
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLA 379

Query: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
           CY G+ + +  LLE    ++       T L  A ++ H   A LLL +   + V+   D 
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS--GAQVNMPADS 437

Query: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873
             +PL  AA   HVE   LL+   A +  V++ G T LM AA  G    V +L+      
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 874 LTVKDKDLNTPLHLACSKGHEKCA 897
               ++   T L LAC  G  + A
Sbjct: 498 NAQTEETQETALTLACCGGFSEVA 521



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 77/275 (28%), Positives = 121/275 (44%), Gaps = 9/275 (3%)

Query: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282

Query: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339

Query: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSI 806
           TPL  A   G+     VLL+         N F  + L  A    H +    LL A   + 
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA--GAD 397

Query: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
              + D+  T L  A    HVE  +LLL   A VN   +S ++ L +AA  G      +L
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
           +    A+L   + +  TPL  A  +GHE+   L+L
Sbjct: 458 IERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLL 491



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 80/279 (28%), Positives = 122/279 (43%), Gaps = 46/279 (16%)

Query: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRG 685
           R+  E + N   VD +       L  A + G ++AV  LL++  +V+     G + L   
Sbjct: 192 RMKAENSHNAGQVDTRS------LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLA 245

Query: 686 IMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKD 744
              G+ E  Q+LL    ++  + ++G  TPL  A++ G+   +  LL   L + D   + 
Sbjct: 246 CSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQS 302

Query: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS 804
             G T L +AC  G  + ++VLL +                A I DH             
Sbjct: 303 ATGNTALTYACAGGFVDIVKVLLNEG---------------ANIEDH------------- 334

Query: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAV 863
                 ++ G TPL  AA A HVE  ++LL H A +N   N  K +AL +A   G    V
Sbjct: 335 ------NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
             L+  A AD   K  +++T L  AC  GH + A L+LD
Sbjct: 389 RFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL      +  GN    TPL  A    + +   LLL  + 
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL--LH 294

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A     V+ +++LL   A +   + +G T LM AA  G     
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L++      T  ++   + L LAC KGH      +L+   D E   +E + AL
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 4/94 (4%)

Query: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNS 869
           ++G + L  A  A + E  Q+LL   A V    N G    +MAA +G  G +DI  L+  
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG--GYLDIVKLLLL 293

Query: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
             AD+  +    NT L  AC+ G      ++L++
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 19/62 (30%), Positives = 33/62 (53%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           TPL  A+  G  E+++ L+ SGA V+A      T L  A  +   +   VL++  AD++ 
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596

Query: 78  RD 79
           ++
Sbjct: 597 QE 598


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  166 bits (421), Expect = 7e-41
 Identities = 128/419 (30%), Positives = 191/419 (45%), Gaps = 39/419 (9%)

Query: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD-NMWLTPLHRAVASR 60
           L+ K +DV+  +   +TPL +AA  G+ EI++ LI +GA  N +D + W      A+ S 
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW-----TALISA 78

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
           S+E                       HV    + +KC         ++   D GG TAL 
Sbjct: 79  SKEG----------------------HVHIVEELLKCG-------VNLEHRDMGGWTALM 109

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            A   G  ++V LLL+ GAN +         + WAA  GH D+V LL+ +GA+V C DK 
Sbjct: 110 WACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY 169

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
           G TPL  AA  G +  VKHLL +G ++D+      TAL +A   G    V E++    NV
Sbjct: 170 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229

Query: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
           N  + +G T L  A+   H  +  +LL + G  VNI  + G + L      G     + L
Sbjct: 230 NLTDKDGNTALMIASKEGHTEIVQDLL-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288

Query: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
           +Q   +ID   +D  T L+ A   G+  ++  +     DT  C      PL  A    + 
Sbjct: 289 LQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNI 348

Query: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD---FHKKDKCGRTP 416
           +    LL  G ++   DK G T LH A  G + +  +LL  +  D    ++ +K G TP
Sbjct: 349 EVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407



 Score =  155 bits (392), Expect = 2e-37
 Identities = 113/357 (31%), Positives = 168/357 (47%), Gaps = 1/357 (0%)

Query: 64  AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
           A++ L++   DV+ R++  QTPL +AA    ++  + +I   ++ N+ D    TAL  A+
Sbjct: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79

Query: 124 LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
             GHV +V  LL  G N+   D     AL WA Y G  DVV LL++HGA  +        
Sbjct: 80  KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
           P+  AA  G  ++V  LL  G +++  + YG T L  A   G    V  L+  GA+V+Q 
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
             N  T L  A    +     E+L  N  +VN+  KDG + L + +  G     Q L+  
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRN-PNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363
           G  ++  D+ G+T L  A R GH  ++  L    AD    G  +   L+ A    ++   
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
           R +L    + +   K G T L  A    N+E ++LL   GA     DK G TPLH A
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score =  139 bits (351), Expect = 9e-33
 Identities = 128/431 (29%), Positives = 199/431 (46%), Gaps = 45/431 (10%)

Query: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN--ETDDWGRTA 449
           N+  +K L     D  ++++CG+TPL  AA   +   ++ L+  GAN N  + D+W  TA
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW--TA 74

Query: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509
           L  A+           G+ H                    +E LL+   N   RD  G+ 
Sbjct: 75  LISASKE---------GHVH-------------------IVEELLKCGVNLEHRDMGGWT 106

Query: 510 SIHYAAAYGHRQCLELLLERTNSGFEESDSGA-TKSPLHLAAYNGHHQALEVLLQSLVDL 568
           ++ +A   G    +ELLL     G   S +G  +  P+  AA  GH   + +LLQ+   +
Sbjct: 107 ALMWACYKGRTDVVELLLSH---GANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV 163

Query: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
           +  D+ G T L  AA KGH ECV+ L+  GA +  ++     T L  +V  G+T  ++ +
Sbjct: 164 NCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEI 222

Query: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
           L+   N   V++ D  G T LM+A   GH + V  LL+    V+  D  G T L   +  
Sbjct: 223 LKRNPN---VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279

Query: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
           GH E V+ LL++   I  +    +T L++A  +G+AT + ++LQ    + + C KD  G 
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ-CNPDTEICTKD--GE 336

Query: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLL-GAIDSSI 806
           TPL  A    N   +E+LL++      +     TPLH AI       A LLL    D  +
Sbjct: 337 TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396

Query: 807 VSCRDDKGRTP 817
           +   +  G TP
Sbjct: 397 LYRPNKAGETP 407



 Score =  135 bits (339), Expect = 2e-31
 Identities = 105/360 (29%), Positives = 169/360 (46%), Gaps = 3/360 (0%)

Query: 95  VKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 154
           +   + ++     V+  +  G+T L  AA  G++E+V  L+  GAN N  D  +  AL  
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77

Query: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
           A+  GH+ +V  L+  G  +  +D  G+T L  A   G+ +VV+ LL+ G       +Y 
Sbjct: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137

Query: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
              +  A   G   +V+ L+  GA VN  +  G TPL +AA   H   C++ L+  GADV
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH-LECVKHLLAMGADV 196

Query: 275 NIQSKDGKSPLHMTAVHGRFTRS-QTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
           + +  +  + L + AV G +T+S + +++    ++  DKDGNT L +A++ GH  ++  L
Sbjct: 197 DQEGANSMTAL-IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
             +G             L  A    H +  R LL    +ID   +  +T L+ A   GN 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 394 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
             ++ +     D     K G TPL  A    +   +E L+  GA V+  D  G T LH A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score =  134 bits (337), Expect = 4e-31
 Identities = 105/407 (25%), Positives = 180/407 (44%), Gaps = 29/407 (7%)

Query: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186
           ++  +  LL K  +++  ++  +  L  AA  G+L++V  LI +GA    +D   +T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
           +A+  G +++V+ LL  GV ++  ++ G TAL  ACY G+  VV  L+ +GAN +     
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306
              P+ +AA   H  + + LL+ NGA VN   K G +PL   A  G     + L+  G +
Sbjct: 137 SVYPIIWAAGRGHADI-VHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
           +D    +  T L VA + G+   +  +     +           L +A+   H++  + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426
           L +G  ++ PD+ G T L  A  GG+VE ++ L    AD   + +  +T L++A    + 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 427 HCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 486
             +  ++    +       G T                          L +A +++  E 
Sbjct: 316 TMVRDILQCNPDTEICTKDGET-------------------------PLIKATKMRNIEV 350

Query: 487 TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
              +E LL   A  S  DK+G   +H A     R+  ELLL     G
Sbjct: 351 ---VELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDG 394



 Score =  122 bits (306), Expect = 2e-27
 Identities = 119/420 (28%), Positives = 190/420 (45%), Gaps = 18/420 (4%)

Query: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCL-ELLLERTNSGFEESDSGA 541
           E+E    L+ LL+   +   R++ G   +  AA  G+ + + EL+    N   E+ D+  
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
               L  A+  GH   +E LL+  V+L+ RD  G TAL  A +KG T+ VE L++ GA+ 
Sbjct: 74  A---LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP 130

Query: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
            V   +    P+  +   GH   + LLL+   N   V+  D  G TPL+ A   GH++ V
Sbjct: 131 SVT-GLYSVYPIIWAAGRGHADIVHLLLQ---NGAKVNCSDKYGTTPLVWAARKGHLECV 186

Query: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
             LL   A+VD       TAL   +  G+ + V+ +L++  ++   D  G T L  A+  
Sbjct: 187 KHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKE 246

Query: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF- 780
           GH   + +LL            D  G T L  A   G+   +  LL++       G    
Sbjct: 247 GHTEIVQDLLDAGTYVN---IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303

Query: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
           T L+ A+   +      +L     + +  +D  G TPL  A    ++E ++LLL   A V
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKD--GETPLIKATKMRNIEVVELLLDKGAKV 361

Query: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQAD--LTVKDKDLNTPLHLACSKGHEKCAL 898
           +AVD  G T L +A         ++L+ + +    L   +K   TP ++ CS  H+K  L
Sbjct: 362 SAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCS--HQKSIL 419



 Score =  120 bits (302), Expect = 4e-27
 Identities = 88/316 (27%), Positives = 148/316 (46%), Gaps = 6/316 (1%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           T L  A + G  +++ELL+  GA  +      + P+  A      + V +L+++ A VN 
Sbjct: 106 TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
            DK   TPL  AA    ++C + ++ + + V+       TAL  A   G+ + V  +L +
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225

Query: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
             N+N  DK    AL  A+  GH ++V  L++ G  V   D+ G T L  A   G + +V
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285

Query: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257
           + LL    +ID       TAL+ A   G   +V +++    +      +G TPL   A  
Sbjct: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL-IKATK 344

Query: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI----QNGGEIDCVDKD 313
                 +ELL++ GA V+   K G +PLH+ A+ GR  +   L+    ++G  +   +K 
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELLLRNPKDGRLLYRPNKA 403

Query: 314 GNTPLHVAARYGHELL 329
           G TP ++   +   +L
Sbjct: 404 GETPYNIDCSHQKSIL 419



 Score =  117 bits (294), Expect = 4e-26
 Identities = 108/417 (25%), Positives = 184/417 (44%), Gaps = 34/417 (8%)

Query: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292
           L++   +V++ N  G TPL  AA   +  +  EL + NGA+ N++  D  + L   +  G
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKEL-IKNGANCNLEDLDNWTALISASKEG 82

Query: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
                + L++ G  ++  D  G T L  A   G   ++  L + GA+ +  G++S++P+ 
Sbjct: 83  HVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPII 142

Query: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412
            AA   H+D    LL +G +++  DK+G T L  AA  G++EC+K L + GAD  ++   
Sbjct: 143 WAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGAN 202

Query: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNS 472
             T L  A    +   ++ ++    NVN TD  G TAL  A+                  
Sbjct: 203 SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIAS------------------ 244

Query: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER-TN 531
                     ++  T  ++ LL      +I D+ G   +  A   GH + +  LL++  +
Sbjct: 245 ----------KEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 294

Query: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591
                 D+   K+ L+ A   G+   +  +LQ   D +I  + G T L  A    + E V
Sbjct: 295 IDIRGQDN---KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351

Query: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
           E L++ GA +   D     TPLH ++         LLL    +   +   +  G+TP
Sbjct: 352 ELLLDKGAKVSAVDK-KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407



 Score =  117 bits (294), Expect = 4e-26
 Identities = 87/283 (30%), Positives = 133/283 (46%), Gaps = 4/283 (1%)

Query: 19  PLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78
           P+  AA  G A+I+ LL+ +GA+VN  D    TPL  A      E V+ L+   ADV+  
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 79  DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138
             N  T L VA      +  + I+    +VN++D+ G TAL  A+  GH E+V  LL  G
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259

Query: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVK 198
             +N  D+     L  A   GH+++V  L+   A++  + +   T L+ A   G   +V+
Sbjct: 260 TYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319

Query: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
            +L    + +     G T L  A       VV  L+D GA V+  +  G TPLH A    
Sbjct: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGR 379

Query: 259 HGALCLELLVNNGADVNI---QSKDGKSPLHMTAVHGRFTRSQ 298
              L  ELL+ N  D  +    +K G++P ++   H +   +Q
Sbjct: 380 SRKLA-ELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421



 Score =  117 bits (292), Expect = 6e-26
 Identities = 111/363 (30%), Positives = 162/363 (44%), Gaps = 17/363 (4%)

Query: 557 ALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHAS 616
           AL+ LL+   D+D R+E G+T L +AA +G+ E V+ LI  GA+  ++D +   T L ++
Sbjct: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLED-LDNWTALISA 78

Query: 617 VINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDI 676
              GH   +  LL+   N   ++ +D  G T LM A   G  D V LLL   AN     +
Sbjct: 79  SKEGHVHIVEELLKCGVN---LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 677 LGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALS 736
                +      GH + V +LL+    + C D  G TPL +AA +GH   +  LL M   
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 737 EEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI---GNPFTPLHCAIINDHGN 793
            +    +     T L  A   G    ++ +L++          GN  T L  A    H  
Sbjct: 196 VDQ---EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGN--TALMIASKEGHTE 250

Query: 794 CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMM 853
               LL A   + V+  D  G T L  A    HVE ++ LL+  A ++      KTAL  
Sbjct: 251 IVQDLLDA--GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308

Query: 854 AAENGQAGAV-DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
           A E G A  V DIL      D  +  KD  TPL  A    + +   L+LDK    S +++
Sbjct: 309 AVEKGNATMVRDIL--QCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366

Query: 913 KNN 915
           K +
Sbjct: 367 KGD 369



 Score =  110 bits (274), Expect = 8e-24
 Identities = 79/254 (31%), Positives = 127/254 (50%), Gaps = 5/254 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+     VN  D    TPL  AA  G  E ++ L+  GA V+ +    +T L  AV   
Sbjct: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214

Query: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
             ++V+ ++K + +VN  DK+  T L +A+     +  + ++   + VN+ DR G T L 
Sbjct: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLI 274

Query: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
            A   GHVE+V  LL K A+I+   + ++ AL+WA   G+  +V  ++    +     K 
Sbjct: 275 GAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD 334

Query: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI----DY 236
           G TPL  A     I VV+ LL+ G ++  ++  G+T LHIA   G+   + EL+      
Sbjct: 335 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA-IRGRSRKLAELLLRNPKD 393

Query: 237 GANVNQPNNNGFTP 250
           G  + +PN  G TP
Sbjct: 394 GRLLYRPNKAGETP 407



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 81/248 (32%), Positives = 122/248 (49%), Gaps = 9/248 (3%)

Query: 657 HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716
           +I A+  LLEK  +VD  +  G T L      G+ E V+ L++   +   +D    T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776
            A+  GH   + ELL+  ++ E    +D  G+T L WACY G  + +E+LL         
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEH---RDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 777 G-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
           G     P+  A    H +   LLL   + + V+C D  G TPL  AA   H+EC++ LL 
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQ--NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191

Query: 836 HSAPVNAVDNSGKTALMMAAENGQAGAV-DILVNSAQADLTVKDKDLNTPLHLACSKGHE 894
             A V+    +  TAL++A + G   +V +IL  +   +LT  DKD NT L +A  +GH 
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLT--DKDGNTALMIASKEGHT 249

Query: 895 KCALLILD 902
           +    +LD
Sbjct: 250 EIVQDLLD 257


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  159 bits (401), Expect = 1e-38
 Identities = 105/332 (31%), Positives = 164/332 (49%), Gaps = 17/332 (5%)

Query: 20  LHVAAFLGDAEI-IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78
           LH+    G  +  I  L+L G R +       T LH AV   + E +  L+   AD+   
Sbjct: 71  LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 130

Query: 79  DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138
                T LH+A     ++ A+V++   ++VN+ D    T LH AA  GH ++  LLL  G
Sbjct: 131 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 190

Query: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHG--AEVTCKDKKGYTPLHAAASNGQINV 196
           A++N   +   R LH A+  G L++  LL+  G  A+V  +D + + PLH  +  G  ++
Sbjct: 191 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDI 250

Query: 197 VKHLLNLGVEIDE--INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
           VK+LL   +E+    +N+YG+T LH+ACYNG+  V  E+I      +    N F+   F 
Sbjct: 251 VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFH 310

Query: 255 AASTHGA---LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV- 310
           +A T+G    L   LL  N  ++N Q +DG + LH    HG     Q L+ NG +++ V 
Sbjct: 311 SACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 370

Query: 311 --------DKDGNTPLHVAARYGHELLINTLR 334
                   +KD  T L  A   GH+ ++  L+
Sbjct: 371 CDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK 402



 Score =  141 bits (355), Expect = 3e-33
 Identities = 95/271 (35%), Positives = 146/271 (53%), Gaps = 9/271 (3%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           T LH+A +  +AE+I  L+ SGA +       LT LH A  +   EA  VL++H A+VN 
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
           +D  + TPLH+AA     +   +++   + VNVS   G   LH A+  G + +  LL+ +
Sbjct: 163 QDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 222

Query: 138 G--ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT--CKDKKGYTPLHAAASNGQ 193
           G  A++NA D +D   LH+ +  GH D+V  L+    EV     +  G TPLH A  NG+
Sbjct: 223 GSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGK 282

Query: 194 INVVKHLLNL-GVE-IDEINVYGNTALHIACYNGQDA-VVNELIDYGA-NVNQPNNNGFT 249
             V K ++ + G E + + N++  TA H AC  G+   +V  L+D    N+N    +G T
Sbjct: 283 FEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHT 342

Query: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKD 280
            LH A    H  L ++ L++NGAD+N+ + D
Sbjct: 343 GLHSACYHGHIRL-VQFLLDNGADMNLVACD 372



 Score =  107 bits (266), Expect = 7e-23
 Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 36/323 (11%)

Query: 214 GNTALHIACY-NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272
           G + LH+ C   G+ + +  L+  G   ++   NGFT LH A    +  L   LL ++GA
Sbjct: 67  GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 125

Query: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
           D+      G + LH+  + G    +  L+Q+G  ++  D    TPLH+AA YGHE +   
Sbjct: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185

Query: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG--FEIDTPDKFGRTCLHAAAAG 390
           L   GAD    G     PLHLA+     +  + L+  G   +++  D      LH  +  
Sbjct: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRF 245

Query: 391 GNVECIKLLQSSGADF--HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD--WG 446
           G+ + +K L  S  +   H  +  G TPLH A  N  F   + ++      + T +  + 
Sbjct: 246 GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFS 305

Query: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLL-QNDANPSIRDK 505
            TA H A            G + D                   ++FLL QN  N + + +
Sbjct: 306 ETAFHSACT---------YGKSID------------------LVKFLLDQNVININHQGR 338

Query: 506 EGYNSIHYAAAYGHRQCLELLLE 528
           +G+  +H A  +GH + ++ LL+
Sbjct: 339 DGHTGLHSACYHGHIRLVQFLLD 361



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 87/360 (24%), Positives = 158/360 (43%), Gaps = 39/360 (10%)

Query: 273 DVNIQSKDGKSPLHMTAV-HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331
           ++N ++++G S LH+  +  G+ +  +TL+  G     + ++G T LH+A    +  LI 
Sbjct: 59  NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118

Query: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGG 391
           +L  SGAD  + G   +  LH+A +  H +    LL  G  ++  D    T LH AA  G
Sbjct: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178

Query: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTA 449
           + +  +LL   GAD +   + G  PLH A+A    +  + L+  G  A+VN  D+     
Sbjct: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238

Query: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND--ANPSIRDKEG 507
           LH+ +              HD                   +++LLQ+D    P + +  G
Sbjct: 239 LHFCSRF----------GHHD------------------IVKYLLQSDLEVQPHVVNIYG 270

Query: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL--QSL 565
              +H A   G  +  + +++ + +     ++  +++  H A   G    L   L  Q++
Sbjct: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330

Query: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625
           ++++ +   G T L  A + GH   V+ L++ GA +    N+    P  +S       CL
Sbjct: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM----NLVACDPSRSSGEKDEQTCL 386



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 97/367 (26%), Positives = 161/367 (43%), Gaps = 25/367 (6%)

Query: 564 SLVDLDIRDEKGRTALDLAAFKGHTEC-VEALINPGASIFVKDNVTKR--TPLHASVING 620
           S V+L+ R E G + L L    G  +  +  L+  G        +T+   T LH +V   
Sbjct: 56  SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLR---PSRLTRNGFTALHLAVYKD 112

Query: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
           +   +  LL    + + V      G T L +A   GH++A  +LL+  ANV+  D +  T
Sbjct: 113 NAELITSLLHSGADIQQVGYG---GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFT 169

Query: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
            LH     GHE+  ++LL+    +      G  PLH A+A+G    +++LL    S+ D 
Sbjct: 170 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN-IAKLLMEEGSKADV 228

Query: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPF--TPLHCAIINDHGNCASL 797
             +DN+ + PLH+    G+ + ++ LL+     +  + N +  TPLH A  N     A  
Sbjct: 229 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKE 288

Query: 798 LLGAIDSSIVSCRDDKGRTPLRAA-AFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAA 855
           ++    +  ++  +    T   +A  +   ++ ++ LL ++   +N     G T L  A 
Sbjct: 289 IIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSAC 348

Query: 856 ENGQAGAVDILV-NSAQADLTVKD-------KDLNTPLHLACSKGHEKCALLI--LDKIQ 905
            +G    V  L+ N A  +L   D       KD  T L  A  KGH+    L+    + Q
Sbjct: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQ 408

Query: 906 DESLINE 912
           DE   NE
Sbjct: 409 DELPCNE 415



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 93/349 (26%), Positives = 146/349 (41%), Gaps = 35/349 (10%)

Query: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
           G +  I TL   G   ++   +    LHLA    +++    LL SG +I      G T L
Sbjct: 79  GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138

Query: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
           H A   G++E   +L   GA+ + +D    TPLH AA   H      L+  GA+VN + +
Sbjct: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198

Query: 445 WGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504
            G   LH A+A                   L  A+ L E+           + A+ + +D
Sbjct: 199 VGDRPLHLASAKGF----------------LNIAKLLMEE----------GSKADVNAQD 232

Query: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564
            E +  +H+ + +GH   ++ LL+          +    +PLHLA YNG  +  + ++Q 
Sbjct: 233 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI 292

Query: 565 LVDLDIRDEK--GRTALDLAAFKGHT-ECVEALINPGASIFVKDNVTKRTPLHASVINGH 621
                +  E     TA   A   G + + V+ L++              T LH++  +GH
Sbjct: 293 SGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGH 352

Query: 622 TLCLRLLLEI-AD-NPEAVDVKDAKG----QTPLMLAVAYGHIDAVSLL 664
              ++ LL+  AD N  A D   + G    QT LM A   GH   V+LL
Sbjct: 353 IRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 69/253 (27%), Positives = 115/253 (45%), Gaps = 17/253 (6%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    +VN  D+   TPLH+AA+ G  ++  LL+  GA VN    +   PLH A A  
Sbjct: 152 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 211

Query: 61  SEEAVQVLIKH--SADVNARDKNWQTPLHVAAANKAVKCAEVII--PLLSSVNVSDRGGR 116
                ++L++    ADVNA+D     PLH  +        + ++   L    +V +  G 
Sbjct: 212 FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD 271

Query: 117 TALHHAALNGHVEMVN--LLLAKGANINAFDKKDRRALHWAAYMG-HLDVVALLINHGA- 172
           T LH A  NG  E+    + ++   ++   +     A H A   G  +D+V  L++    
Sbjct: 272 TPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331

Query: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI---------NVYGNTALHIACY 223
            +  + + G+T LH+A  +G I +V+ LL+ G +++ +              T L  A  
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391

Query: 224 NGQDAVVNELIDY 236
            G DA+V  L  Y
Sbjct: 392 KGHDAIVTLLKHY 404


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  159 bits (401), Expect = 1e-38
 Identities = 105/332 (31%), Positives = 164/332 (49%), Gaps = 17/332 (5%)

Query: 20  LHVAAFLGDAEI-IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78
           LH+    G  +  I  L+L G R +       T LH AV   + E +  L+   AD+   
Sbjct: 172 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 231

Query: 79  DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138
                T LH+A     ++ A+V++   ++VN+ D    T LH AA  GH ++  LLL  G
Sbjct: 232 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 291

Query: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHG--AEVTCKDKKGYTPLHAAASNGQINV 196
           A++N   +   R LH A+  G L++  LL+  G  A+V  +D + + PLH  +  G  ++
Sbjct: 292 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDI 351

Query: 197 VKHLLNLGVEIDE--INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
           VK+LL   +E+    +N+YG+T LH+ACYNG+  V  E+I      +    N F+   F 
Sbjct: 352 VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFH 411

Query: 255 AASTHGA---LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV- 310
           +A T+G    L   LL  N  ++N Q +DG + LH    HG     Q L+ NG +++ V 
Sbjct: 412 SACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 471

Query: 311 --------DKDGNTPLHVAARYGHELLINTLR 334
                   +KD  T L  A   GH+ ++  L+
Sbjct: 472 CDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK 503



 Score =  141 bits (355), Expect = 3e-33
 Identities = 95/271 (35%), Positives = 146/271 (53%), Gaps = 9/271 (3%)

Query: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
           T LH+A +  +AE+I  L+ SGA +       LT LH A  +   EA  VL++H A+VN 
Sbjct: 204 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 263

Query: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
           +D  + TPLH+AA     +   +++   + VNVS   G   LH A+  G + +  LL+ +
Sbjct: 264 QDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 323

Query: 138 G--ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT--CKDKKGYTPLHAAASNGQ 193
           G  A++NA D +D   LH+ +  GH D+V  L+    EV     +  G TPLH A  NG+
Sbjct: 324 GSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGK 383

Query: 194 INVVKHLLNL-GVE-IDEINVYGNTALHIACYNGQDA-VVNELIDYGA-NVNQPNNNGFT 249
             V K ++ + G E + + N++  TA H AC  G+   +V  L+D    N+N    +G T
Sbjct: 384 FEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHT 443

Query: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKD 280
            LH A    H  L ++ L++NGAD+N+ + D
Sbjct: 444 GLHSACYHGHIRL-VQFLLDNGADMNLVACD 473



 Score =  107 bits (266), Expect = 7e-23
 Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 36/323 (11%)

Query: 214 GNTALHIACY-NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272
           G + LH+ C   G+ + +  L+  G   ++   NGFT LH A    +  L   LL ++GA
Sbjct: 168 GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 226

Query: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
           D+      G + LH+  + G    +  L+Q+G  ++  D    TPLH+AA YGHE +   
Sbjct: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286

Query: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG--FEIDTPDKFGRTCLHAAAAG 390
           L   GAD    G     PLHLA+     +  + L+  G   +++  D      LH  +  
Sbjct: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRF 346

Query: 391 GNVECIKLLQSSGADF--HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD--WG 446
           G+ + +K L  S  +   H  +  G TPLH A  N  F   + ++      + T +  + 
Sbjct: 347 GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFS 406

Query: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLL-QNDANPSIRDK 505
            TA H A            G + D                   ++FLL QN  N + + +
Sbjct: 407 ETAFHSACT---------YGKSID------------------LVKFLLDQNVININHQGR 439

Query: 506 EGYNSIHYAAAYGHRQCLELLLE 528
           +G+  +H A  +GH + ++ LL+
Sbjct: 440 DGHTGLHSACYHGHIRLVQFLLD 462



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 87/360 (24%), Positives = 158/360 (43%), Gaps = 39/360 (10%)

Query: 273 DVNIQSKDGKSPLHMTAV-HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331
           ++N ++++G S LH+  +  G+ +  +TL+  G     + ++G T LH+A    +  LI 
Sbjct: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219

Query: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGG 391
           +L  SGAD  + G   +  LH+A +  H +    LL  G  ++  D    T LH AA  G
Sbjct: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279

Query: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTA 449
           + +  +LL   GAD +   + G  PLH A+A    +  + L+  G  A+VN  D+     
Sbjct: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339

Query: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND--ANPSIRDKEG 507
           LH+ +              HD                   +++LLQ+D    P + +  G
Sbjct: 340 LHFCSRF----------GHHD------------------IVKYLLQSDLEVQPHVVNIYG 371

Query: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL--QSL 565
              +H A   G  +  + +++ + +     ++  +++  H A   G    L   L  Q++
Sbjct: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431

Query: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625
           ++++ +   G T L  A + GH   V+ L++ GA +    N+    P  +S       CL
Sbjct: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM----NLVACDPSRSSGEKDEQTCL 487



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 97/367 (26%), Positives = 161/367 (43%), Gaps = 25/367 (6%)

Query: 564 SLVDLDIRDEKGRTALDLAAFKGHTEC-VEALINPGASIFVKDNVTKR--TPLHASVING 620
           S V+L+ R E G + L L    G  +  +  L+  G        +T+   T LH +V   
Sbjct: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLR---PSRLTRNGFTALHLAVYKD 213

Query: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
           +   +  LL    + + V      G T L +A   GH++A  +LL+  ANV+  D +  T
Sbjct: 214 NAELITSLLHSGADIQQVGYG---GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFT 270

Query: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
            LH     GHE+  ++LL+    +      G  PLH A+A+G    +++LL    S+ D 
Sbjct: 271 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN-IAKLLMEEGSKADV 329

Query: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPF--TPLHCAIINDHGNCASL 797
             +DN+ + PLH+    G+ + ++ LL+     +  + N +  TPLH A  N     A  
Sbjct: 330 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKE 389

Query: 798 LLGAIDSSIVSCRDDKGRTPLRAA-AFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAA 855
           ++    +  ++  +    T   +A  +   ++ ++ LL ++   +N     G T L  A 
Sbjct: 390 IIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSAC 449

Query: 856 ENGQAGAVDILV-NSAQADLTVKD-------KDLNTPLHLACSKGHEKCALLI--LDKIQ 905
            +G    V  L+ N A  +L   D       KD  T L  A  KGH+    L+    + Q
Sbjct: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQ 509

Query: 906 DESLINE 912
           DE   NE
Sbjct: 510 DELPCNE 516



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 93/349 (26%), Positives = 146/349 (41%), Gaps = 35/349 (10%)

Query: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
           G +  I TL   G   ++   +    LHLA    +++    LL SG +I      G T L
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239

Query: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
           H A   G++E   +L   GA+ + +D    TPLH AA   H      L+  GA+VN + +
Sbjct: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299

Query: 445 WGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504
            G   LH A+A                   L  A+ L E+           + A+ + +D
Sbjct: 300 VGDRPLHLASAKGF----------------LNIAKLLMEE----------GSKADVNAQD 333

Query: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564
            E +  +H+ + +GH   ++ LL+          +    +PLHLA YNG  +  + ++Q 
Sbjct: 334 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI 393

Query: 565 LVDLDIRDEK--GRTALDLAAFKGHT-ECVEALINPGASIFVKDNVTKRTPLHASVINGH 621
                +  E     TA   A   G + + V+ L++              T LH++  +GH
Sbjct: 394 SGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGH 453

Query: 622 TLCLRLLLEI-AD-NPEAVDVKDAKG----QTPLMLAVAYGHIDAVSLL 664
              ++ LL+  AD N  A D   + G    QT LM A   GH   V+LL
Sbjct: 454 IRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 69/253 (27%), Positives = 115/253 (45%), Gaps = 17/253 (6%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+    +VN  D+   TPLH+AA+ G  ++  LL+  GA VN    +   PLH A A  
Sbjct: 253 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 312

Query: 61  SEEAVQVLIKH--SADVNARDKNWQTPLHVAAANKAVKCAEVII--PLLSSVNVSDRGGR 116
                ++L++    ADVNA+D     PLH  +        + ++   L    +V +  G 
Sbjct: 313 FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD 372

Query: 117 TALHHAALNGHVEMVN--LLLAKGANINAFDKKDRRALHWAAYMG-HLDVVALLINHGA- 172
           T LH A  NG  E+    + ++   ++   +     A H A   G  +D+V  L++    
Sbjct: 373 TPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 432

Query: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI---------NVYGNTALHIACY 223
            +  + + G+T LH+A  +G I +V+ LL+ G +++ +              T L  A  
Sbjct: 433 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492

Query: 224 NGQDAVVNELIDY 236
            G DA+V  L  Y
Sbjct: 493 KGHDAIVTLLKHY 505


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  157 bits (397), Expect = 4e-38
 Identities = 185/668 (27%), Positives = 278/668 (41%), Gaps = 68/668 (10%)

Query: 4   HKTEDVNTLDSEKRTPLHVAAFLGDAEIIE--------LLILSGARVNAKDNMWLTPLHR 55
           + +E+    D E+     V +F+ D + +E         L+LSG    A D   + P  +
Sbjct: 114 NNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGA-DLRTVDPETQ 172

Query: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA--EVIIPLL-----SSV 108
           A      EA  +    +AD     K +  P  +     +V CA  E    L      S+ 
Sbjct: 173 ARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTA 228

Query: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168
           N      R+ L  A   G V  V  LL +G ++N   ++    L  A   G+ ++  +L+
Sbjct: 229 NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287

Query: 169 NHGAEVTCKDKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227
              A V  +  KG  TPL AAA+ G + +VK LL    +++  +  GNTAL  AC  G  
Sbjct: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347

Query: 228 AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287
            VV  L++ GA++   N NG TPL  A ++ H  +   LL+ NGA +N  S + K     
Sbjct: 348 DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFK----- 401

Query: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347
                                       + L +A   GH  ++  L  +GAD        
Sbjct: 402 ---------------------------ESALTLACYKGHLEMVRFLLEAGADQEHKTDEM 434

Query: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
              L  A ++ H +  R LL SG +++ P     + L  AA GG+VE   LL   GA   
Sbjct: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494

Query: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILG 466
           + +  G TPL  AA   H   +  L+  GAN+N +T++   TAL  A           L 
Sbjct: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554

Query: 467 NAHDNSEELERARELKE--KEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCL 523
            A  +  EL  +  L E  +E  L  +++LL   AN       G  ++ YA   GH    
Sbjct: 555 KAGADI-ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 524 ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD-IRDEKGRTALDLA 582
           ++LL+       ES+ G T  PL  AA  GH   ++ L+    +++        T L LA
Sbjct: 614 DVLLQAGADLEHESEGGRT--PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 583 AFKGHTECVEALINPGA--SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV 640
              GH   VE L+  GA  +  +KD     T L  +   GHT  +  LL+  +N  +   
Sbjct: 672 CAGGHLAVVELLLAHGADPTHRLKDG---STMLIEAAKGGHTSVVCYLLDYPNNLLSAPP 728

Query: 641 KDAKGQTP 648
            D    TP
Sbjct: 729 PDVTQLTP 736



 Score =  148 bits (374), Expect = 2e-35
 Identities = 146/497 (29%), Positives = 213/497 (42%), Gaps = 21/497 (4%)

Query: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
           L  A S G +N V+ LL  G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 245 NNG-FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
             G  TPL  AA   H  + ++LL+ + ADVN QS  G + L      G     + L+++
Sbjct: 298 IKGDITPLMAAANGGHVKI-VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356

Query: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSDC 362
           G  I+  +++G+TPL  A   GH  +   L  +GA             L LA    H + 
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
            R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA 
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476

Query: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
             H      L+  GA++ E +D G T L  AA    +    +L     N     +  E +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA--QTEETQ 534

Query: 483 EKEATLCL--------EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
           E   TL          +FL++  A+  +        +  AA  GH + ++ LL    +  
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVH 591

Query: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
             + +G T   L  A  NGH    +VLLQ+  DL+   E GRT L  AA  GH   V+ L
Sbjct: 592 ATTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
           I+ GA++         T L  +   GH   + LLL    +P    +KD  G T L+ A  
Sbjct: 650 ISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP-THRLKD--GSTMLIEAAK 706

Query: 655 YGHIDAVSLLLEKEANV 671
            GH   V  LL+   N+
Sbjct: 707 GGHTSVVCYLLDYPNNL 723



 Score =  145 bits (367), Expect = 1e-34
 Identities = 126/430 (29%), Positives = 198/430 (46%), Gaps = 26/430 (6%)

Query: 84   TPLHVAAAN---------KAVKCAEVIIPLLSSVNV---SDRGGRTALHHAALNGHVEMV 131
            TP H  AA+           +     ++P+  ++++   ++    TAL  A   GH E+V
Sbjct: 1040 TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELV 1099

Query: 132  NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY-TPLHAAAS 190
              LL +GA+I   DKK    L  AA  GH+ VV +L+++GA++  + ++   TPL  A S
Sbjct: 1100 QTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159

Query: 191  NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GF 248
             G+  VV+ LL  G   +  NV   T L +A   G   ++  L++ GA +N    +  G 
Sbjct: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219

Query: 249  TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP-LHMTAVHGRFTRSQTLIQNGGEI 307
            +PL  AA + H A  ++LL++ G+D+N Q +  ++  L +    GR      L+     +
Sbjct: 1220 SPLMLAAMNGHTA-AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278

Query: 308  DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHSDCCRK 365
            +   K G TPL  AA  G+  +   L   GAD     + S     L +AA   H   C  
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338

Query: 366  LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
            L+  G  ID  +K G T L  AA GG+++ ++LL  +GAD    D    TPL  A    H
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 426  FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
               +  LV     VN+         + A  +D    K +L   H   E + +A++ +  E
Sbjct: 1399 VKVVRYLV---KEVNQFPSDSECMRYIATITD----KEMLKKCHLCMESIVQAKDRQAAE 1451

Query: 486  ATLCLEFLLQ 495
            A      LL+
Sbjct: 1452 ANKNASILLE 1461



 Score =  145 bits (365), Expect = 2e-34
 Identities = 107/321 (33%), Positives = 156/321 (48%), Gaps = 38/321 (11%)

Query: 51   TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
            T L  A A   EE VQ L++  A +  RDK   TPL +AA    V   E+++   + +  
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 111  -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
             S+R   T L  A   G  E+V LLLA+GAN    +  D   L  AA  G+++++ +L+N
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 170  HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226
             GAE+  +   K G +PL  AA NG    VK LL++G +I+ +I    NTAL +AC+ G+
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 227  DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG------------------------AL 262
              VV+ L+D  ANV      G TPL  AA+  +                         AL
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324

Query: 263  CL----------ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312
             +          ELL+  GA +++++K G +PL + A  G     Q L+Q G ++D  D 
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1384

Query: 313  DGNTPLHVAARYGHELLINTL 333
               TPL  A R GH  ++  L
Sbjct: 1385 RKITPLMAAFRKGHVKVVRYL 1405



 Score =  139 bits (351), Expect = 9e-33
 Identities = 120/401 (29%), Positives = 187/401 (46%), Gaps = 12/401 (2%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L HK  DVN   S   T L  A   G  +++++L+ SGA +   +    TPL  A ++ 
Sbjct: 320 LLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378

Query: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
             E  ++L+++ A +N     + ++ L +A     ++    ++   +          TAL
Sbjct: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
           ++    +   TPL  AA   H  L ++ L+  GA+V+  +  G + L     +G    + 
Sbjct: 559 DIELGCS---TPLMEAAQEGHLEL-VKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614

Query: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD---TAKCGIHSMFPLHLAA 355
            L+Q G +++   + G TPL  AAR GH   +  L + GA+   T     H++  L LA 
Sbjct: 615 VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTV--LSLAC 672

Query: 356 LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI 396
              H      LL+ G +     K G T L  AA GG+   +
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713



 Score =  139 bits (349), Expect = 2e-32
 Identities = 138/503 (27%), Positives = 203/503 (40%), Gaps = 57/503 (11%)

Query: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
           N    D +S L      G     + L+  G  ++   ++G + L +A   G+  L   L 
Sbjct: 229 NAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287

Query: 335 TSGADTAKCGIHS-MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393
              A+    GI   + PL  AA   H    + LL+   +++     G T L  A AGG V
Sbjct: 288 AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYV 347

Query: 394 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
           + +K+L  SGA     ++ G TPL  A +  H      L+  GA +N             
Sbjct: 348 DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN------------- 394

Query: 454 AASDMDRNKTILGNAHDNSEELERARELKEKEATLC--------LEFLLQNDANPSIRDK 505
                          H N        E KE   TL         + FLL+  A+   +  
Sbjct: 395 --------------THSN--------EFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432

Query: 506 EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL 565
           E + ++  A   GH +   LLL+        +DS   +SPL LAA  GH +   +L++  
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERG 490

Query: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625
             L+  +++G T L  AA +GH E V  L+  GA+I  +   T+ T L  +   G     
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGG----- 545

Query: 626 RLLLEIADNPEAVDVKDAKG-QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684
              LE+AD           G  TPLM A   GH++ V  LL   ANV      G TAL  
Sbjct: 546 --FLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTY 603

Query: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD 744
               GH +   +LL+    +  +   GRTPL  AA  GH   +  L+    +        
Sbjct: 604 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT--TA 661

Query: 745 NQGYTPLHWACYNGNENCIEVLL 767
           N  +T L  AC  G+   +E+LL
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLL 684



 Score =  136 bits (343), Expect = 8e-32
 Identities = 138/486 (28%), Positives = 219/486 (45%), Gaps = 25/486 (5%)

Query: 427 HCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 486
           + +  L+  G +VNE  + G + L  A ++       +L   H N E+     ++    A
Sbjct: 248 NAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMA 307

Query: 487 TL------CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
                    ++ LL + A+ + +   G  ++ YA A G+   +++LLE   S  + +++G
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367

Query: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIR-DEKGRTALDLAAFKGHTECVEALINPGA 599
            T  PL  A   GH +   +LL++   ++   +E   +AL LA +KGH E V  L+  GA
Sbjct: 368 HT--PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425

Query: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
               K +    T L  + ++GH    RLLL   D+   V++     ++PL LA   GH++
Sbjct: 426 DQEHKTD-EMHTALMEACMDGHVEVARLLL---DSGAQVNMPADSFESPLTLAACGGHVE 481

Query: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYA 718
             +LL+E+ A+++ V+  G T L      GHEE V +LL Q  +I  + +    T L  A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIG 777
              G       L++     E  C       TPL  A   G+   ++ LL           
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS------TPLMEAAQEGHLELVKYLLAAGANVHATTA 595

Query: 778 NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS 837
              T L  A  N H + A +LL A   + +    + GRTPL  AA A HV  +Q L+   
Sbjct: 596 TGDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653

Query: 838 APVN-AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
           A VN    N+  T L +A   G    V++L+ +  AD T + KD +T L  A   GH   
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLL-AHGADPTHRLKDGSTMLIEAAKGGHTSV 712

Query: 897 ALLILD 902
              +LD
Sbjct: 713 VCYLLD 718



 Score =  131 bits (329), Expect = 3e-30
 Identities = 119/402 (29%), Positives = 181/402 (45%), Gaps = 17/402 (4%)

Query: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564
           +EG + +  A + G+ +  ++LL   ++  E+       +PL  AA  GH + +++LL  
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAM-HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323

Query: 565 LVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLC 624
             D++ +   G TAL  A   G+ + V+ L+  GASI    N    TPL  +   GH   
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI-EDHNENGHTPLMEAGSAGHVEV 382

Query: 625 LRLLLEIADNPEAVDVKDAK-GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALH 683
            RLLLE   N   ++    +  ++ L LA   GH++ V  LLE  A+ +       TAL 
Sbjct: 383 ARLLLE---NGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALM 439

Query: 684 RGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFK 743
              M GH E  ++LL+    +        +PL  AA  GH    + L++   S E+    
Sbjct: 440 EACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV--- 496

Query: 744 DNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAIINDHGNCASLLLGA 801
           +++GYTPL  A   G+E  + +LL Q      +      T L  A        A  L+ A
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556

Query: 802 IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAG 861
                + C      TPL  AA   H+E ++ LL   A V+A   +G TAL  A ENG   
Sbjct: 557 GADIELGCS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611

Query: 862 AVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
             D+L+  A ADL  + +   TPL  A   GH      ++ K
Sbjct: 612 VADVLL-QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652



 Score =  127 bits (318), Expect = 6e-29
 Identities = 120/394 (30%), Positives = 177/394 (44%), Gaps = 39/394 (9%)

Query: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
            L LA   GH + ++ LL+    ++ RD+KG T L LAA  GH   VE L++ GA I  + 
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146

Query: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
              TK TPL  +   G    + LLL    N E  +V D    TPL LA + G+++ + +LL
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1203

Query: 666  E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
                E N  T   LG + L    M GH   V++LL+    I  + ++   T L  A  +G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
                +S LL    + E    +   G TPL  A   G      VLL++         P   
Sbjct: 1264 RTEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320

Query: 781  -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
             T L  A    H     LL+G    + +  R+ KG TPL  AA   H++ +QLL++  A 
Sbjct: 1321 DTALTIAADKGHYKFCELLIGR--GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378

Query: 840  VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQAD-------LTVKDKDLNTPLHLA- 888
            V+A DN   T LM A   G    V  L   VN   +D        T+ DK++    HL  
Sbjct: 1379 VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCM 1438

Query: 889  ----------CSKGHEKCALLI----LDKIQDES 908
                       ++ ++  ++L+    L+K+++ES
Sbjct: 1439 ESIVQAKDRQAAEANKNASILLEELDLEKLREES 1472



 Score =  125 bits (314), Expect = 2e-28
 Identities = 103/334 (30%), Positives = 166/334 (49%), Gaps = 10/334 (2%)

Query: 2    LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAVASR 60
            L+ +   +   D +  TPL +AA  G   ++E+L+ +GA + A+      TPL  A +  
Sbjct: 1102 LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGG 1161

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN--VSDRGGRTA 118
             +E V++L+   A+   R+ +  TPL +AA+   V   ++++   + +N     + G + 
Sbjct: 1162 RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP 1221

Query: 119  LHHAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCK 177
            L  AA+NGH   V LLL  G++INA  + +R  AL  A + G  +VV+LL++  A V  +
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281

Query: 178  DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG--NTALHIACYNGQDAVVNELID 235
             K G TPL  AAS G   V + LL+ G +++   V    +TAL IA   G       LI 
Sbjct: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIG 1341

Query: 236  YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFT 295
             GA+++  N  G TPL  AA   H  + ++LLV  GADV+       +PL      G   
Sbjct: 1342 RGAHIDVRNKKGNTPLWLAANGGHLDV-VQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1400

Query: 296  RSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELL 329
              + L++   E++    D     ++A     E+L
Sbjct: 1401 VVRYLVK---EVNQFPSDSECMRYIATITDKEML 1431



 Score =  116 bits (291), Expect = 8e-26
 Identities = 85/269 (31%), Positives = 134/269 (49%), Gaps = 5/269 (1%)

Query: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
           +L+     VN       +PL +AA  G  E+  LLI  GA +   ++   TPL  A    
Sbjct: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511

Query: 61  SEEAVQVLIKHSADVNAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
            EE V +L+   A++NA+ ++  +T L +A     ++ A+ +I   + + +   G  T L
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPL 568

Query: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
             AA  GH+E+V  LLA GAN++A       AL +A   GH DV  +L+  GA++  + +
Sbjct: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628

Query: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG-NTALHIACYNGQDAVVNELIDYGA 238
            G TPL  AA  G +  V+ L++ G  ++       +T L +AC  G  AVV  L+ +GA
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688

Query: 239 NVNQPNNNGFTPLHFAAASTHGALCLELL 267
           +      +G T L  AA   H ++   LL
Sbjct: 689 DPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score =  106 bits (265), Expect = 9e-23
 Identities = 113/409 (27%), Positives = 175/409 (42%), Gaps = 37/409 (9%)

Query: 242  QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
            Q  +N  T L  A A  H  L ++ L+  GA +  + K G +PL + A  G     + L+
Sbjct: 1078 QTESNHDTALTLACAGGHEEL-VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136

Query: 302  QNGGEIDCV-DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
             NG +I+   ++  +TPL +A   G + ++  L   GA+     +    PL LAA   + 
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196

Query: 361  DCCRKLLSSGFEID--TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPL 417
            +  + LL++G EI+  T  K G + L  AA  G+   +KLL   G+D + + +  R T L
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256

Query: 418  HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
              A        +  L+   ANV      G T L  AA+                    E 
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY----------------AEV 1300

Query: 478  ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
             R L +K A +           PS RD     ++  AA  GH +  ELL+ R       +
Sbjct: 1301 GRVLLDKGADV------NAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRN 1350

Query: 538  DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
              G T  PL LAA  GH   +++L+Q+  D+D  D +  T L  A  KGH + V  L+  
Sbjct: 1351 KKGNT--PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408

Query: 598  GASIFVKDNVTKR---TPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643
              + F  D+   R   T     ++    LC+  +++  D   A   K+A
Sbjct: 1409 -VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1456



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 69/206 (33%), Positives = 105/206 (50%), Gaps = 5/206 (2%)

Query: 1    MLIHKTEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAV 57
            +L++   ++N+    K   +PL +AA  G    ++LL+  G+ +NA+ +    T L  A 
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260

Query: 58   ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD--RGG 115
                 E V +L+   A+V  R K   TPL  AA+    +   V++   + VN        
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320

Query: 116  RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
             TAL  AA  GH +   LL+ +GA+I+  +KK    L  AA  GHLDVV LL+  GA+V 
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380

Query: 176  CKDKKGYTPLHAAASNGQINVVKHLL 201
              D +  TPL AA   G + VV++L+
Sbjct: 1381 AADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 80/250 (32%), Positives = 121/250 (48%), Gaps = 14/250 (5%)

Query: 660  AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
            A+ +  + E+N DT   L C         GHEE VQ LLE+  SI  +D +G TPL  AA
Sbjct: 1072 AIDIDAQTESNHDTALTLACAG-------GHEELVQTLLERGASIEHRDKKGFTPLILAA 1124

Query: 720  ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778
              GH   +  LL      E     +    TPL  AC  G +  +E+LL +   ++    +
Sbjct: 1125 TAGHVGVVEILLDNGADIE--AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182

Query: 779  PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837
             +TPL  A    + N   +LL A  + I S    K G +PL  AA   H   ++LLL   
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241

Query: 838  APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
            + +NA ++ +  TAL +A   G+   V +L++  +A++  + K   TPL  A S G+ + 
Sbjct: 1242 SDINAQIETNRNTALTLACFQGRTEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1300

Query: 897  ALLILDKIQD 906
              ++LDK  D
Sbjct: 1301 GRVLLDKGAD 1310



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 85/287 (29%), Positives = 126/287 (43%), Gaps = 12/287 (4%)

Query: 637  AVDVK---DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693
            A+D+    ++   T L LA A GH + V  LLE+ A+++  D  G T L      GH   
Sbjct: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131

Query: 694  VQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
            V++LL+    I  +  R + TPL  A + G    +  LL    ++E    ++   YTPL 
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE---HRNVSDYTPLS 1188

Query: 753  WACYNGNENCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSC 809
             A   G  N I++LL          G+    +PL  A +N H     LLL  + S I + 
Sbjct: 1189 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQ 1247

Query: 810  RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN- 868
             +    T L  A F    E + LLL   A V     +G T LM AA  G A    +L++ 
Sbjct: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307

Query: 869  SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
             A  +        +T L +A  KGH K   L++ +     + N+K N
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1354



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 72/278 (25%), Positives = 117/278 (42%), Gaps = 38/278 (13%)

Query: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMTGHEECVQ 695
           +V+    +G++ L LA + G+ +   +LL   ANV+   I G  T L      GH + V+
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318

Query: 696 MLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWAC 755
           +LL  +  +  + S G T L YA A G+   +  LL+   S ED    +  G+TPL  A 
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED---HNENGHTPLMEAG 375

Query: 756 YNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGR 815
             G+     +LLE                 A IN H N                  +   
Sbjct: 376 SAGHVEVARLLLENG---------------AGINTHSN------------------EFKE 402

Query: 816 TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLT 875
           + L  A +  H+E ++ LL   A      +   TALM A  +G      +L++S  A + 
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG-AQVN 461

Query: 876 VKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
           +      +PL LA   GH + A L++++      +N++
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE 499



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 4/126 (3%)

Query: 776  IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
            I  P TP    II+            ID+   S  D    T L  A    H E +Q LL 
Sbjct: 1049 ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD----TALTLACAGGHEELVQTLLE 1104

Query: 836  HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEK 895
              A +   D  G T L++AA  G  G V+IL+++        ++  +TPL LACS G ++
Sbjct: 1105 RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 1164

Query: 896  CALLIL 901
               L+L
Sbjct: 1165 VVELLL 1170



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 47/175 (26%), Positives = 73/175 (41%), Gaps = 5/175 (2%)

Query: 746 QGYTPLHWACYNGNENCIEVLLEQKCF--RKFIGNPFTPLHCAIINDHGNCASLLLGAID 803
           +G + L  AC  G     +VLL        + I    TPL  A    H     LLL    
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLA--H 323

Query: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
            + V+ +   G T L  A    +V+ +++LL   A +   + +G T LM A   G     
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA 383

Query: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
            +L+ +     T  ++   + L LAC KGH +    +L+   D E   +E + AL
Sbjct: 384 RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 3/124 (2%)

Query: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
            +LI +   ++  + +  TPL +AA  G  ++++LL+ +GA V+A DN  +TPL  A    
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397

Query: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
              + V+ L+K   +VN    + +   ++A         +  + + S V   DR    A  
Sbjct: 1398 HVKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANK 1454

Query: 121  HAAL 124
            +A++
Sbjct: 1455 NASI 1458


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,718,303
Number of Sequences: 37866
Number of extensions: 1561232
Number of successful extensions: 21918
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 369
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 3034
Number of HSP's gapped (non-prelim): 6403
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.