BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|241666464 tuberous sclerosis 1 protein isoform 4 [Homo sapiens] (1113 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|241666464 tuberous sclerosis 1 protein isoform 4 [Homo sapiens] 2240 0.0 gi|4507693 tuberous sclerosis 1 protein isoform 1 [Homo sapiens] 2216 0.0 gi|241666462 tuberous sclerosis 1 protein isoform 3 [Homo sapiens] 2210 0.0 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 74 6e-13 gi|16262452 cingulin [Homo sapiens] 68 4e-11 gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 68 6e-11 gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 64 1e-09 gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 63 1e-09 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 62 4e-09 gi|38044112 restin isoform b [Homo sapiens] 62 4e-09 gi|4506751 restin isoform a [Homo sapiens] 62 4e-09 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 4e-09 gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 4e-09 gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 61 5e-09 gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 9e-09 gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 60 1e-08 gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 60 1e-08 gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 60 2e-08 gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 2e-08 gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 59 2e-08 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 59 2e-08 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 59 2e-08 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 59 2e-08 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 59 2e-08 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 59 2e-08 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 59 2e-08 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 59 2e-08 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 59 2e-08 gi|169208018 PREDICTED: similar to Golgin subfamily A member 8-l... 58 4e-08 gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 58 4e-08 >gi|241666464 tuberous sclerosis 1 protein isoform 4 [Homo sapiens] Length = 1113 Score = 2240 bits (5804), Expect = 0.0 Identities = 1113/1113 (100%), Positives = 1113/1113 (100%) Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 Query: 61 LTTLQEPHDKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGH 120 LTTLQEPHDKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGH Sbjct: 61 LTTLQEPHDKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGH 120 Query: 121 VAEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHP 180 VAEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHP Sbjct: 121 VAEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHP 180 Query: 181 ELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSAD 240 ELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSAD Sbjct: 181 ELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSAD 240 Query: 241 VTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSM 300 VTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSM Sbjct: 241 VTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSM 300 Query: 301 VCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISL 360 VCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISL Sbjct: 301 VCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISL 360 Query: 361 PQATVTPPRKEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEED 420 PQATVTPPRKEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEED Sbjct: 361 PQATVTPPRKEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEED 420 Query: 421 SIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASV 480 SIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASV Sbjct: 421 SIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASV 480 Query: 481 NPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPP 540 NPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPP Sbjct: 481 NPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPP 540 Query: 541 TRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDR 600 TRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDR Sbjct: 541 TRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDR 600 Query: 601 LIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQ 660 LIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQ Sbjct: 601 LIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQ 660 Query: 661 HALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTM 720 HALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTM Sbjct: 661 HALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTM 720 Query: 721 VTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQV 780 VTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQV Sbjct: 721 VTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQV 780 Query: 781 SQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKN 840 SQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKN Sbjct: 781 SQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKN 840 Query: 841 RSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQ 900 RSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQ Sbjct: 841 RSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQ 900 Query: 901 KRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEA 960 KRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEA Sbjct: 901 KRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEA 960 Query: 961 SGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEAS 1020 SGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEAS Sbjct: 961 SGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEAS 1020 Query: 1021 ASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKI 1080 ASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKI Sbjct: 1021 ASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKI 1080 Query: 1081 PLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS 1113 PLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS Sbjct: 1081 PLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS 1113 >gi|4507693 tuberous sclerosis 1 protein isoform 1 [Homo sapiens] Length = 1164 Score = 2216 bits (5742), Expect = 0.0 Identities = 1113/1164 (95%), Positives = 1113/1164 (95%), Gaps = 51/1164 (4%) Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 Query: 61 LTTLQEPHDK-------------------------------------------------- 70 LTTLQEPHDK Sbjct: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120 Query: 71 -MDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 129 MDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL Sbjct: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180 Query: 130 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 189 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH Sbjct: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240 Query: 190 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 249 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT Sbjct: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300 Query: 250 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 309 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT Sbjct: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360 Query: 310 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 369 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR Sbjct: 361 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 420 Query: 370 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 429 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA Sbjct: 421 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 480 Query: 430 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 489 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL Sbjct: 481 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 540 Query: 490 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 549 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ Sbjct: 541 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 600 Query: 550 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 609 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH Sbjct: 601 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 660 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL Sbjct: 661 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 720 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 729 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR Sbjct: 721 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 780 Query: 730 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 789 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES Sbjct: 781 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 840 Query: 790 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 849 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ Sbjct: 841 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 900 Query: 850 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL Sbjct: 901 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 960 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 969 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT Sbjct: 961 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1020 Query: 970 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1029 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS Sbjct: 1021 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1080 Query: 1030 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1089 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP Sbjct: 1081 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1140 Query: 1090 SPPTPDSVGQLHIMDYNETHHEHS 1113 SPPTPDSVGQLHIMDYNETHHEHS Sbjct: 1141 SPPTPDSVGQLHIMDYNETHHEHS 1164 >gi|241666462 tuberous sclerosis 1 protein isoform 3 [Homo sapiens] Length = 1163 Score = 2210 bits (5726), Expect = 0.0 Identities = 1112/1164 (95%), Positives = 1112/1164 (95%), Gaps = 52/1164 (4%) Query: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI Sbjct: 1 MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI 60 Query: 61 LTTLQEPHDK-------------------------------------------------- 70 LTTLQEPHDK Sbjct: 61 LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL 120 Query: 71 -MDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 129 MDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL Sbjct: 121 KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL 180 Query: 130 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 189 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH Sbjct: 181 HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH 240 Query: 190 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 249 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT Sbjct: 241 ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT 300 Query: 250 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 309 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT Sbjct: 301 QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT 360 Query: 310 SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 369 SPGNVPPDLSHPYSKVFGTT GGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR Sbjct: 361 SPGNVPPDLSHPYSKVFGTT-GGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR 419 Query: 370 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 429 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA Sbjct: 420 KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA 479 Query: 430 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 489 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL Sbjct: 480 AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL 539 Query: 490 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 549 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ Sbjct: 540 DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ 599 Query: 550 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 609 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH Sbjct: 600 PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH 659 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL Sbjct: 660 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 719 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 729 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR Sbjct: 720 RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR 779 Query: 730 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 789 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES Sbjct: 780 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 839 Query: 790 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 849 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ Sbjct: 840 VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ 899 Query: 850 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL Sbjct: 900 RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 959 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 969 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT Sbjct: 960 EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT 1019 Query: 970 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1029 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS Sbjct: 1020 PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS 1079 Query: 1030 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1089 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP Sbjct: 1080 LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP 1139 Query: 1090 SPPTPDSVGQLHIMDYNETHHEHS 1113 SPPTPDSVGQLHIMDYNETHHEHS Sbjct: 1140 SPPTPDSVGQLHIMDYNETHHEHS 1163 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 74.3 bits (181), Expect = 6e-13 Identities = 101/400 (25%), Positives = 180/400 (45%), Gaps = 41/400 (10%) Query: 567 HFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLP--LPSKSVD 624 H + +TE L +A G +E S+ +++D+ QQ AD K L++L L K + Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSE--KLMDKE-QQVADLQLK-LSRLEEQLKEKVTN 475 Query: 625 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRN--RRLLRKVIKAAALEEHN 682 T + + Q L Q + + Q+ L R++ K K LE Sbjct: 476 STELQHQLDKTKQQHQEQQAL---QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532 Query: 683 AAMKDQLKLQEKDIQMWKVSLQK---EQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 739 K+ + L EK+ + +Q E A NQLQE+ T L Q+ QL E+ Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT----LQEQVTQLT---EKLK 585 Query: 740 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEF--- 796 NQS+ + E+ + + E + L+ A ++V E +++++ +L+ S+ Q++ Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645 Query: 797 LNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 856 +LL+ E + H DT + K ++EL K + + Q T +L Q+ Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQE 702 Query: 857 RILELESHLA--KKDHLLLEQK--------KYLEDVKLQARGQLQAAESRYEAQKRITQV 906 +LESHL K+ +L LEQK K LE L+ + + A + Q+++ Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762 Query: 907 FELEILDLYGRLEKDGLL---KKLE-EEKAEAAEAAEERL 942 EL +L +LE + + +L+ ++K+EA E+ +++L Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802 Score = 68.9 bits (167), Expect = 2e-11 Identities = 77/360 (21%), Positives = 162/360 (45%), Gaps = 36/360 (10%) Query: 573 TEELLKKAKGNT---EEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 629 TE LLKK + T E+ S S + L Q+ D + ++L S+ H Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ-SRLSASETSLHRIHVE 366 Query: 630 GSPPSDEIRTLRDQLLLLHN----------QLLYERFKRQQHALRNR----RLLRKVIKA 675 S + + L+++L + QL +R +++QH L+ + +L K+++ Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426 Query: 676 AA-LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQ---RDTMVTKLHSQIRQL 731 L E + +K+Q +L + + + + Q + ++L+EQ + T T+L Q+ + Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486 Query: 732 QHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQ 791 + +E Q KL + +N + ++ ++ + K+ + E LL + + +S E + Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546 Query: 792 QQMEFLNRQLLVLGEVNELYLEQLQNKH-------SDTTKEVEMMKAAYRKELEKNRSHV 844 + + + GE L QLQ K+ + T++++ ++++ E V Sbjct: 547 EDL----YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602 Query: 845 LQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQ---LQAAESRYEAQK 901 +Q L +Q R+L LE+ + + + L E K+ + + +Q + + L +AE+ AQ+ Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662 Score = 53.5 bits (127), Expect = 1e-06 Identities = 80/387 (20%), Positives = 162/387 (41%), Gaps = 33/387 (8%) Query: 570 IRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 629 ++K E L+ K + + + L Q+ H + N++ + Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847 Query: 630 GSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 689 E+ T++D+L + + L + + ++ + + + + K +H ++ + Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907 Query: 690 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKL---HSQIRQLQHDREEFYNQSQELQ 746 L+E+ + K SL+KE+ +QL+ + ++M +L + ++Q + + ++ EL+ Sbjct: 908 TLKEQ--KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965 Query: 747 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 806 E + I L+ ELK A V L +++ Q+L+ + Q++ ++ VL Sbjct: 966 QSSEQKKKQIEALQGELKIA---VLQKTELENKLQQQLTQAA---QELAAEKEKISVLQN 1019 Query: 807 VNELYLEQLQNKHSD-------------TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 853 E E + SD K VE + +++L NR+ + Q + + Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079 Query: 854 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 913 + LE AKK+ L E+ K L+D+ Q L+ E E K EI + Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDI--QKEKSLKEKELVNEKSKL------AEIEE 1131 Query: 914 LYGRLEKDGLLKKLEEEKAEAAEAAEE 940 + R EK+ + K EE K+ E+ +E Sbjct: 1132 IKCRQEKE-ITKLNEELKSHKLESIKE 1157 Score = 51.2 bits (121), Expect = 5e-06 Identities = 60/271 (22%), Positives = 121/271 (44%), Gaps = 31/271 (11%) Query: 690 KLQEKDIQMWKVSLQKEQARYNQLQEQRD----------TMVTKLHSQI----RQLQHDR 735 KL+E ++ + Q +A + QLQ+QR+ + + +LHS++ RQL Sbjct: 376 KLKE-ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434 Query: 736 EEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME 795 Q Q KL D +A+L+++L + ++ +++ +L ++ Q+ + Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494 Query: 796 FLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE------LEKNRSHVLQQTQ 849 L + + LEQ+ + D ++++ ++A +K LEK R + + Q Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554 Query: 850 RLDTSQKRILELESHLAKKDHLLLEQKKYL-EDVKLQARGQLQAAES---RYEAQKRITQ 905 + +L + L +K+H L EQ L E +K Q+ QA E+ + + QK + Sbjct: 555 -AGEGETAVL---NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610 Query: 906 VFELEILDLYGRLEKDGLLKKLEEEKAEAAE 936 + +L L + + L +L E K + ++ Sbjct: 611 AAQDRVLSLETSVNE--LNSQLNESKEKVSQ 639 Score = 50.1 bits (118), Expect = 1e-05 Identities = 61/316 (19%), Positives = 140/316 (44%), Gaps = 32/316 (10%) Query: 636 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKD 695 E+ ++++QL+ N L + QQ L+ I L++ + K Q++ + + Sbjct: 932 ELNSMQEQLIQAQNTLKQNEKEEQQ--------LQGNINE--LKQSSEQKKKQIEALQGE 981 Query: 696 IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ---IRQLQHDREEFYNQSQELQTKLEDC 752 + K+++ ++ N+LQ+Q +L ++ I LQ++ E+ ++LQ+ Sbjct: 982 L---KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038 Query: 753 RNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYL 812 + + R +LK K+ + L ++ N + Q+++ L E + Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL----EQDSAKK 1094 Query: 813 EQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA------ 866 EQ + ++++ K+ KEL +S + + + +K I +L L Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154 Query: 867 -KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLK 925 K+ L + K+ L KL+ +G+ + ++ E +KR Q+ + ++ + E++ L K Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV-----KKEEEELKK 1209 Query: 926 KLEEEKAEAAEAAEER 941 + E++A+ +E+ Sbjct: 1210 EFIEKEAKLHSEIKEK 1225 Score = 49.7 bits (117), Expect = 2e-05 Identities = 77/357 (21%), Positives = 158/357 (44%), Gaps = 40/357 (11%) Query: 567 HFVIRKTEELL--KKAKGNTEEDGVPSTSPME-VLDRLIQQGADAHSKELNKLPLPSKSV 623 +F I++ ++L K A+ TE + S E L +Q ++ELNK + + Sbjct: 151 NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210 Query: 624 DWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNA 683 T P +++ L+ +L+ + + +R++ + + + +K+ A E Sbjct: 211 K-TELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATI 269 Query: 684 A-MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQS 742 + ++ +L +++ ++ LQK ++ N+L ++ T+ L +E+ Y Sbjct: 270 SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK--------KEQDY--- 318 Query: 743 QELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLL 802 TKLE+ N E + K + +L Q+ +LS SE+ + ++ +L Sbjct: 319 ----TKLEEKHN---EESVSKKNIQATLHQKDLDCQQLQSRLSASET---SLHRIHVELS 368 Query: 803 VLGEVNELYLEQLQNKHSDTTKEVEMMKAAYR---KELEKNRSHVLQQTQRLDTSQKRIL 859 GE + E+L S+ + + +KA ++ ++ E+ H LQ ++ ++L Sbjct: 369 EKGEATQKLKEEL----SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL 424 Query: 860 ELESHLAKKDHLLLEQKKYLEDVKLQARGQ----LQAAESRYEAQ--KRITQVFELE 910 E E L + H L++++ L KL + Q LQ SR E Q +++T EL+ Sbjct: 425 ETERQLGEA-HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480 Score = 47.0 bits (110), Expect = 1e-04 Identities = 60/284 (21%), Positives = 129/284 (45%), Gaps = 23/284 (8%) Query: 636 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK- 694 +++++ ++L L L+ R +L++++ A A E ++A K+Q +LQE+ Sbjct: 1048 DLKSVEEKLSLAQEDLISNR----NQIGNQNKLIQELKTAKATLEQDSAKKEQ-QLQERC 1102 Query: 695 ----DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLE 750 DIQ K +KE + + + + +I +L + + +S + T L+ Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162 Query: 751 DCRNMIAELRIELK-KANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEV 807 D + ++ + ++EL+ KA++ E Q+ + E + + EF+ ++ + E+ Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222 Query: 808 NELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAK 867 E E KH + ++ M A L +N V ++ Q +SQ+R+ ELE Sbjct: 1223 KE--KEVGMKKHEENEAKLTMQITA----LNENLGTVKKEWQ---SSQRRVSELEKQTDD 1273 Query: 868 KDHLLLEQKKYLEDVKLQARGQLQ-AAESRYEAQKRITQVFELE 910 + + +++ + + R L+ + E +K T+V EL+ Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317 Score = 45.1 bits (105), Expect = 4e-04 Identities = 74/315 (23%), Positives = 129/315 (40%), Gaps = 67/315 (21%) Query: 680 EHNAAMK-DQLKLQEKDIQMWKVSLQ----------KEQARYNQLQEQR---DTMVTKLH 725 E N A+K D + L +++Q + SL+ KE +Y LQ+Q D +VT Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134 Query: 726 SQIRQLQHDREE--------------FYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 ++++ L+ EE F ++ +L T++ D ++ E R + A KV Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194 Query: 772 H----------------TELLLSQVSQKLS--NSESVQQQMEFLNRQLLVLGEVNELYLE 813 TELL + ++ E VQ Q N L E +L E Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254 Query: 814 --QLQNKHSDTTKEVEMMK----------AAYRKELEKNRSHVLQQTQRLDTSQKRILEL 861 +LQ++++ + + ++ A Y +EL+K +S V + TQ+ T + +L+ Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314 Query: 862 ESHLAKKDHLLLEQ---KKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL 918 E K + E+ KK ++ Q Q +SR A + +E+ Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL------S 368 Query: 919 EKDGLLKKLEEEKAE 933 EK +KL+EE +E Sbjct: 369 EKGEATQKLKEELSE 383 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 68.2 bits (165), Expect = 4e-11 Identities = 89/392 (22%), Positives = 176/392 (44%), Gaps = 38/392 (9%) Query: 572 KTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADA-HSKELNKLPLPSKSVDWTHFGG 630 + +ELL++ KG ++ S ++ + RL+ QG D H E + L +K H G Sbjct: 405 RLQELLERRKGEAQQ----SNKELQNMKRLLDQGEDLRHGLETQVMELQNKL---KHVQG 457 Query: 631 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKA--AALEEHNAAMKDQ 688 P+ E+ L+D LL +LL E + +Q RL + + A AL+E A+ + Sbjct: 458 PEPAKEV-LLKD--LLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514 Query: 689 LK----LQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 744 ++ ++D + + S+Q + L+ +R M + R+L+ EE + Sbjct: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574 Query: 745 LQTKLEDCR---NMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 801 Q ED R + +LR+E ++ ++ +L + ++ S +Q+E L ++L Sbjct: 575 FQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKEL 634 Query: 802 L-VLGEVNELYLE----QLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 856 L E+ EL E ++ +H D +E+E A R E ++ R Q Q T Q+ Sbjct: 635 LRTQEELKELQAERQSQEVAGRHRD--RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQ 692 Query: 857 RILELE-----SHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEI 911 + E +A+ + +L Q++ + L+ + E E ++RI + E ++ Sbjct: 693 LRQDCEEASKAKMVAEAEATVLGQRRAAVETTLR-----ETQEENDEFRRRILGL-EQQL 746 Query: 912 LDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD 943 + G ++ ++ +K + EA +++L+ Sbjct: 747 KETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778 Score = 48.9 bits (115), Expect = 3e-05 Identities = 82/325 (25%), Positives = 138/325 (42%), Gaps = 32/325 (9%) Query: 636 EIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKD 695 ++ L+ +LL +L + +RQ + R R++ K A+ A +L +E++ Sbjct: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL--EEQN 683 Query: 696 IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNM 755 +Q+ K +Q R + + + MV + + + L R +E Q + ++ R Sbjct: 684 LQLQKTL---QQLRQDCEEASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRR 738 Query: 756 IAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQM-EFLNR------QLLVLGEVN 808 I L +LK+ V E + +++ KL E+ +QQ+ E LN L Sbjct: 739 ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRAL 798 Query: 809 ELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKK 868 E LE+ Q + +E + + A E E + VL++ + QKR+L+ Sbjct: 799 EARLEEAQRGLARLGQEQQTLNRAL--EEEGKQREVLRRGKAELEEQKRLLD-----RTV 851 Query: 869 DHLLLEQKKYLEDVKLQARGQLQAAESRY-EAQKRITQVFELEILDLYGRLEK-DGLLKK 926 D L E +K ED K QA QLQA Y E +R + + D EK G L + Sbjct: 852 DRLNKELEKIGEDSK-QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910 Query: 927 LEEE--------KAEAAEAAEERLD 943 L++E +A AE RLD Sbjct: 911 LQDEIQRLRQALQASQAERDTARLD 935 Score = 47.8 bits (112), Expect = 6e-05 Identities = 64/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%) Query: 666 RRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLH 725 R+L +V K LE ++ QL+ + ++ + L++ + Q ++ M +L Sbjct: 373 RKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM-KRLL 431 Query: 726 SQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLS 785 Q L+H E Q ELQ KL+ + + LK + T LL +V L Sbjct: 432 DQGEDLRHGLE---TQVMELQNKLKHVQGPEPAKEVLLKD----LLETRELLEEV---LE 481 Query: 786 NSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVL 845 + V++Q+ R+L L L+ + + +EVE ++ Y+++ E+ R + Sbjct: 482 GKQRVEEQLRLRERELTALKGA-------LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQ 534 Query: 846 QQTQR---LDTSQKRIL--------ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAE 894 TQ L+ ++++ ELE + H +K ED++ + LQ Sbjct: 535 DATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594 Query: 895 SRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMV 954 + E ++ + + E+ +L G +++E K E EE + + S + Sbjct: 595 EKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVA 654 Query: 955 GHNEE 959 G + + Sbjct: 655 GRHRD 659 Score = 47.0 bits (110), Expect = 1e-04 Identities = 88/374 (23%), Positives = 151/374 (40%), Gaps = 62/374 (16%) Query: 572 KTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGS 631 K E+L++ K EE RL+ + D +KEL K+ SK Sbjct: 828 KQREVLRRGKAELEEQ-----------KRLLDRTVDRLNKELEKIGEDSKQA-------- 868 Query: 632 PPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKL 691 ++ L+ QL E +K + A R ++ K A E + L Sbjct: 869 -----LQQLQAQL---------EDYKEK--ARREVADAQRQAKDWASEAEKTS--GGLSR 910 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 + +IQ + +LQ QA + + ++ + +L L+ + E + +L+ Sbjct: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQG----LEQEAENKKRSQDDRARQLKG 966 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQM--EFLNRQLLVLGEVNE 809 ++ L EL + N V ELL +V++ + ++ ++ E RQ L E ++ Sbjct: 967 LEEKVSRLETELDEEKNTV---ELLTDRVNRGRDQVDQLRTELMQERSARQDL---ECDK 1020 Query: 810 LYLEQLQNKHSDT---TKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 866 + LE+ QNK T + E +A +LE +++ +LQ+ RL ++ L+S Sbjct: 1021 ISLER-QNKDLKTRLASSEGFQKPSASLSQLE-SQNQLLQE--RLQAEEREKTVLQSTNR 1076 Query: 867 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKK 926 K + + E +ED + Q R +A KR E EI L DGL KK Sbjct: 1077 KLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERL------DGLRKK 1130 Query: 927 LEEEKAEAAEAAEE 940 + E E E E+ Sbjct: 1131 AQREVEEQHEVNEQ 1144 Score = 37.7 bits (86), Expect = 0.061 Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 9/141 (6%) Query: 601 LIQQGADAHSKELNKLPLPSKSVDW-----THFGGSPPSDEIRTLRDQLLLLHNQLLYER 655 L+Q+ + E +K+ L ++ D + G PS + L Q LL +L E Sbjct: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065 Query: 656 FKRQQHALRNRRLLRKV----IKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 711 ++ NR+L RKV I+ +H KDQL L+ K ++ ++E R + Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125 Query: 712 QLQEQRDTMVTKLHSQIRQLQ 732 L+++ V + H QLQ Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQ 1146 >gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] Length = 1233 Score = 67.8 bits (164), Expect = 6e-11 Identities = 87/397 (21%), Positives = 180/397 (45%), Gaps = 60/397 (15%) Query: 589 VPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLH 648 V +S ++ ++++Q +S+EL KL + K+ ++ F G+ S ++ +++ L Sbjct: 99 VGGSSEYKINNKVVQ--LHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFE 156 Query: 649 N-----QLLYERFKRQQ-------------HALRNRRLLRKVIKAAALE-EHNAAMKDQL 689 +L E KR++ H +N RK K E + +KD++ Sbjct: 157 EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEV 216 Query: 690 KLQEKDIQMWKV--------SLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 741 + +Q++K+ L KE A N+ E+ + K+ ++++ + + + + Sbjct: 217 VRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE 276 Query: 742 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ----MEFL 797 Q+++ ++++ + + + R + KA H L + L N++ ++ M+ L Sbjct: 277 QQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL 336 Query: 798 NRQLLVLGEVNELYLEQL----QNKHSDTTKEVEMMKAAYR--KELEKNRSHVLQQTQRL 851 +++L + + + + E++ Q++ D T E +K +R +E K + + Q+ ++ Sbjct: 337 EKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKF 396 Query: 852 DTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEI 911 + QK A +D L LE++K +E + + + +L+ E E QKRI E Sbjct: 397 NRDQK---------ADQDRLDLEERKKVE-TEAKIKQKLREIE---ENQKRI------EK 437 Query: 912 LDLYGRLEKDGL--LKKLEEEKAEAAEAAEERLDCCN 946 L+ Y K L KKLE E E E A+ R+D N Sbjct: 438 LEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEIN 474 Score = 50.1 bits (118), Expect = 1e-05 Identities = 46/250 (18%), Positives = 118/250 (47%), Gaps = 24/250 (9%) Query: 686 KDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL 745 K+QLK + + MW+ +++K++ +L+++ + + + QLQ + NQ Sbjct: 825 KNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQ----DLKNQHLAK 880 Query: 746 QTKLEDCRNMIAELRIELKKANNKVCHTE----LLLSQVSQKLSNSESVQQQMEFLNRQL 801 ++++ D + + E+R +L AN ++ H + + +++ QK S+ ++ Q + + +L Sbjct: 881 KSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKL 940 Query: 802 -LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKEL------------EKNRSHVLQQT 848 L G ++++ E+ ++ D+ + + + Y +E K+ + Sbjct: 941 PLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIK 1000 Query: 849 QRLDTSQKRILELES---HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQ 905 Q ++T Q+++ E +S +A + +E+ + + D + + +AA R + K+ + Sbjct: 1001 QEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFE 1060 Query: 906 VFELEILDLY 915 + E D + Sbjct: 1061 QIKKERFDRF 1070 Score = 31.2 bits (69), Expect = 5.7 Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 33/156 (21%) Query: 808 NELYLEQLQNKHSDTTKEVEMMKAAYRKELE----KNRSHVLQQTQRLDTSQKRILELES 863 +E +++L+ K T+E++ A RKE E ++++H LQ RL SQ + + ++ Sbjct: 667 DEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQ--MRLKYSQSDLEQTKT 724 Query: 864 -HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE--K 920 HLA L L++K LE +L R KRI Q E E+ DL ++ + Sbjct: 725 RHLA----LNLQEKSKLE-------SELANFGPRINDIKRIIQSREREMKDLKEKMNQVE 773 Query: 921 DGL------------LKKLEEEKAEAA-EAAEERLD 943 D + +++ EEEK + E A++RL+ Sbjct: 774 DEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLE 809 >gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] Length = 841 Score = 63.5 bits (153), Expect = 1e-09 Identities = 75/310 (24%), Positives = 133/310 (42%), Gaps = 40/310 (12%) Query: 637 IRTLRDQLLL--LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 694 +R L+DQ+ + Q E + +ALR AALE+ A +L + + Sbjct: 310 LRALQDQVSIQSADAQEQVEGLLAENNALRT--------SLAALEQIQTAKTQELNMLRE 361 Query: 695 DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRN 754 LQ++QA Y L Q+D L+SQ+++ Q QE+ + E Sbjct: 362 QTTGLAAELQQQQAEYEDLMGQKD----DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 417 Query: 755 MIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ 814 + E R +K K EL + + +K + E + L + VLG V Y + Sbjct: 418 ELQEARKSAEK--RKAMLDELAMETLQEKSQHKEELGAVR--LRHEKEVLG-VRARYERE 472 Query: 815 LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLE 874 L+ H D ++ E ++ R+E + T+ L+T Q+ + EL++ + H + Sbjct: 473 LRELHEDKKRQEEELRGQIREEKAR--------TRELETLQQTVEELQAQV----HSMDG 520 Query: 875 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEA 934 K + E +A LQ + + E ++ + Q E +L G+ E +L++ + + Sbjct: 521 AKGWFERRLKEAEESLQ--QQQQEQEEALKQCREQHAAELKGKEE------ELQDVRDQL 572 Query: 935 AEAAEERLDC 944 +A EER DC Sbjct: 573 EQAQEER-DC 581 Score = 60.1 bits (144), Expect = 1e-08 Identities = 77/329 (23%), Positives = 142/329 (43%), Gaps = 38/329 (11%) Query: 630 GSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 689 G PP T+ + L +L +E K ++ L + + ++++ E + ++ Sbjct: 173 GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL---QGLESSKQAETSRLQEELA 229 Query: 690 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQEL 745 KL EK L+K+Q + +LQ +++T+ ++I +LQ +E + ++Q+L Sbjct: 230 KLSEK--------LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKL 281 Query: 746 QTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME-------FLN 798 Q +LE +AELR + + ++ H L + Q S Q+Q+E L Sbjct: 282 QQELEAANQSLAELRDQ--RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALR 339 Query: 799 RQLLVLGEVNELYLEQLQNKHSDTT---KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQ 855 L L ++ ++L TT E++ +A Y ++L + + Q Q + Sbjct: 340 TSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY-EDLMGQKDDLNSQLQESLRAN 398 Query: 856 KRILE-LESHLAKKDHL---LLEQKKYLEDVKLQ----ARGQLQAAESRYEAQKRITQVF 907 R+LE L+ +K+ L L E +K E K A LQ E + Sbjct: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458 Query: 908 ELEILDLYGRLEKDGLLKKLEEEKAEAAE 936 E E+L + R E++ L++L E+K E Sbjct: 459 EKEVLGVRARYERE--LRELHEDKKRQEE 485 >gi|210032790 hypothetical protein LOC27146 [Homo sapiens] Length = 1060 Score = 63.2 bits (152), Expect = 1e-09 Identities = 76/330 (23%), Positives = 150/330 (45%), Gaps = 36/330 (10%) Query: 618 LPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA 677 LP +S + G P + L Q L + NQ L + + R+ L+ A Sbjct: 176 LPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQ-----------AT 224 Query: 678 LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN-QLQEQRDTMVTKLHSQIRQLQHDRE 736 E N A++ ++ Q +W+ ++ R N Q+QE + L +Q+R+L+ D E Sbjct: 225 YERENEAIRQAMQ-QSVSQALWQWQEKESDLRKNFQVQE------SALQAQVRKLEGDLE 277 Query: 737 EFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQ----- 791 + +L+ + + I +L ++LK+A + + ++ +KL+ ++ Sbjct: 278 HRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQEC 337 Query: 792 ---QQMEFLNRQLL----VLGEVNELYLEQLQNKHSDT-TKEVEMMKAAYRKELEKNRSH 843 QQ + + +L+ VL E N+L L + + KE MK + +K S Sbjct: 338 RGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASA 397 Query: 844 VLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQ-KR 902 + ++ R ++ ++ KK HL + K LED+ + ++++ S EA+ K+ Sbjct: 398 ETEYMKQQYEEDLRKIKHQTEEEKK-HLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKK 456 Query: 903 ITQVFELEILDLYGRLEKDGLLKKLEEEKA 932 + + E ++ ++ + EK+ +K+LEEEKA Sbjct: 457 LQREVEAQLEEVRKKSEKE--IKQLEEEKA 484 Score = 44.7 bits (104), Expect = 5e-04 Identities = 90/402 (22%), Positives = 163/402 (40%), Gaps = 67/402 (16%) Query: 635 DEIRTLRDQLL-----LLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQL 689 +E + L+DQL+ L+ + + R ++L R+V A LEE + ++ Sbjct: 419 EEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREV--EAQLEEVRKKSEKEI 476 Query: 690 KLQEKDIQMWKVSLQK---EQARYNQLQEQRDTMVTKLHSQIRQL--QH----------- 733 K E++ V LQ E R + +Q T T ++L QH Sbjct: 477 KQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCL 536 Query: 734 DREEFYNQSQELQTKL-----------EDCRNMIAE-------LRIELKKANNKVCHTE- 774 +E + +E Q KL E + ++ E L LK+ +K+ E Sbjct: 537 KLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEE 596 Query: 775 -------LLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE 827 L +QVSQ ++++Q L L ++++L E+LQ + +TT++ Sbjct: 597 DWQSQKAKLQAQVSQM---QQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNH 653 Query: 828 MMKAAYRKELEKNRSHVLQ-----QTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 MKA +LE + L+ + Q L +++R+ + SH + H + L+ + Sbjct: 654 AMKA----QLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQH--QTHRLELQAL 707 Query: 883 KLQARGQLQAAESRYEAQKR-ITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEER 941 + +AR +LQ R +AQ+ + + E+ + G K LE +AE ++ Sbjct: 708 EEKARQELQEERERMQAQQALLLESLRQELSEQQAAC--SGHQKDLEALQAELRALGRQQ 765 Query: 942 LDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRG 983 G S + EE G G+ +P ++ +GS G Sbjct: 766 ASSQCPGDSKDHIIATEERGG-PGQAGSPPGAAGQGSGEGCG 806 Score = 40.8 bits (94), Expect = 0.007 Identities = 63/241 (26%), Positives = 100/241 (41%), Gaps = 45/241 (18%) Query: 650 QLLYERFKRQQHALRNRRLLRKVIKAAA--LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQ 707 Q L ER + L+ R +K A L E A KD++ LQE Sbjct: 291 QKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQE-------------- 336 Query: 708 ARYNQLQEQRDTMVTKLHSQIRQL--QHDREEFYNQSQELQTKLEDCRNMIAELRIELKK 765 R Q Q D M T+L S+ + L ++D E Q+ Q+ L++C M ++ KK Sbjct: 337 CRGTQ---QTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKK 393 Query: 766 ANNKVCHTELLLSQVSQKLSN-SESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 824 + TE + Q + L +++ + L QL+ LE L KH+ K Sbjct: 394 EAS--AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKR-------LEDLVKKHTVEIK 444 Query: 825 EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKL 884 V A RK+L++ L++ ++ S+K I +LE ++K +VKL Sbjct: 445 SVRSSVEAERKKLQREVEAQLEEVRK--KSEKEIKQLE------------EEKAALNVKL 490 Query: 885 Q 885 Q Sbjct: 491 Q 491 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 61.6 bits (148), Expect = 4e-09 Identities = 80/412 (19%), Positives = 183/412 (44%), Gaps = 45/412 (10%) Query: 551 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 609 P + HL P H ++ K K A+ + D P T+P + +D Sbjct: 34 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 86 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 K++N P + T G P DE + H + L + Q H +R Sbjct: 87 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 138 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 711 + ++ A +A QL+ + +D+ WK + + EQA RY Sbjct: 139 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 196 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 +L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+ Sbjct: 197 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252 Query: 772 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 831 +LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++ Sbjct: 253 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ- 310 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 891 + +++++ + +Q +++ ++++ E + +K+ + Q++ + + + + R Q + Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370 Query: 892 AAESRYEAQKRITQVF---ELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEE 940 + E +R ++ E +I +L ++ + +++ EE++ E + E+ Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422 Score = 55.5 bits (132), Expect = 3e-07 Identities = 54/316 (17%), Positives = 141/316 (44%), Gaps = 27/316 (8%) Query: 635 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 694 +E+ +++ + ++++E+ ++ + K+ + + +++Q K QE+ Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428 Query: 695 DIQMWKVSLQKEQARYNQLQEQRDTM---VTKLHSQIR----QLQHDREEFYNQSQELQT 747 + +MW+ +K + + +++EQ M K+H Q + + + ++EE + Q +++ Sbjct: 429 EAKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487 Query: 748 KLEDCRNM--IAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLG 805 + E R + E +++K KV E + + +K+ E + E R+ + Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547 Query: 806 EVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHL 865 E EQ + + +E E +++ + V +Q +++ +++ E E + Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607 Query: 866 AKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLK 925 K++ + EQ++ +++ + + R Q E + Q+ +TQ E++ + Sbjct: 608 WKQEEKIREQEEKIQEQEEKIREQ----EEKIREQEEMTQ-------------EQEEKMG 650 Query: 926 KLEEEKAEAAEAAEER 941 + EE+ E E +E+ Sbjct: 651 EQEEKMCEQEEKMQEQ 666 Score = 51.6 bits (122), Expect = 4e-06 Identities = 38/225 (16%), Positives = 97/225 (43%), Gaps = 31/225 (13%) Query: 682 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 741 N ++++ QE+ IQ W+ +Q+++ + + +E+ K+ Q + E+ Q Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354 Query: 742 SQELQTKLEDCR---NMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLN 798 + + K E R M+ E ++++ + E + ++ +K+ E +++Q E Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE--- 411 Query: 799 RQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRI 858 K E K +++ ++ + + +Q +++ +++I Sbjct: 412 -------------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446 Query: 859 LELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 903 E E + +++ + EQ+K E+ K Q + ++ E + Q+ I Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEI 491 Score = 47.8 bits (112), Expect = 6e-05 Identities = 51/273 (18%), Positives = 124/273 (45%), Gaps = 27/273 (9%) Query: 647 LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKE 706 +H Q R K + H + +RK + +E +++ K++E++ +MW+ Q+E Sbjct: 485 IHEQEEIWRQKEKMHEQEEK--IRKQEEKVWRQEEKIREQEE-KIREQEEKMWR---QEE 538 Query: 707 QARYNQLQEQRDTMVTKLHSQIR-----QLQHDREEFYNQSQELQTKLEDCRNMIAELRI 761 + R QE+ K+H Q + + Q ++ + Q ++++ + E ++R Sbjct: 539 KIRE---QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595 Query: 762 ELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSD 821 + +K + E + Q + E +Q+Q E + Q + E E+ EQ + Sbjct: 596 QEEKRQEQ---EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652 Query: 822 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL-- 879 K E +++++ + +Q +++ +K+I E E + +++ ++ EQ++ + Sbjct: 653 EEKMCEQ-----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707 Query: 880 -EDVKLQARGQLQAAESRYEAQKRITQVFELEI 911 E+ + ++Q E + Q+ +++E E+ Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEV 738 Score = 44.7 bits (104), Expect = 5e-04 Identities = 46/300 (15%), Positives = 134/300 (44%), Gaps = 15/300 (5%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 713 E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++ Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEM 385 Query: 714 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 769 +++ + +L ++ + + RE+ + +E Q K ++ + ++++ K Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445 Query: 770 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 824 + E + + +K+ E + +Q+ E + RQ + E E++ Q + H K Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW-RQKEKMHEQEEK 504 Query: 825 EVEMMKAAYRKE--LEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 + + +R+E + + + +Q +++ +++I E E +++ + ++K + E+ Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564 Query: 883 KLQARGQLQAAESRYEAQKRITQVFELEILDL-YGRLEKDGLLKKLEEEKAEAAEAAEER 941 + + ++ E + Q+ E +I + R E++ + K EE+ E E +E+ Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 61.6 bits (148), Expect = 4e-09 Identities = 68/326 (20%), Positives = 143/326 (43%), Gaps = 31/326 (9%) Query: 631 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALR----NRRLLRKVIKAAALEEHNAAMK 686 S E++ LR QL Q+ + ++ + + R L + +K L+E+ + + Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 797 Query: 687 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 746 + EK++Q+ K + +Q V KLH + E+F S +L+ Sbjct: 798 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK-------EEQFNMLSSDLE 850 Query: 747 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 806 E+ +M A+ R + ++ + E L + +++ + S Q+ +N +L Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL----R 906 Query: 807 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 866 + E +E+LQ K + + ++ + K + ++ + +K + S L Sbjct: 907 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966 Query: 867 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-----EKD 921 KK + + + +L+AR + +E++ + ++ I Q + +LD +L E Sbjct: 967 KK-----METSHNQCQELKARYERATSETKTKHEE-ILQNLQKTLLDTEDKLKGAREENS 1020 Query: 922 GLLKKLEE-----EKAEAAEAAEERL 942 GLL++LEE +KA+AA+ AE+ + Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAM 1046 Score = 60.1 bits (144), Expect = 1e-08 Identities = 65/318 (20%), Positives = 139/318 (43%), Gaps = 24/318 (7%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA----MKDQL 689 S ++ LR+ L + + + + +Q +L + + + N++ M D+L Sbjct: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905 Query: 690 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ----IRQLQHDREEFYNQSQEL 745 +L+E+D++ ++ L K + LQ+ + M K ++ + +++E + +L Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965 Query: 746 QTKLEDCRNMIAELRIELKKANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLV 803 + K+E N EL+ ++A + K H E+L + L + ++ E + Sbjct: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGL 1022 Query: 804 LGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-------LEKNRSHVLQQTQRLDTSQK 856 L E+ EL + + K + T ++ + KE LE + + LDT ++ Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082 Query: 857 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG 916 L+ L K LL + + +E+ + + QAA + + Q Q +++ + G Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ-QLSALQEENVKLAEELG 1141 Query: 917 RLEKDGLL--KKLEEEKA 932 R +D + +KLEEE++ Sbjct: 1142 R-SRDEVTSHQKLEEERS 1158 Score = 43.9 bits (102), Expect = 9e-04 Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 44/319 (13%) Query: 660 QHALRNRRLLRKVIKAAALEEHNAAMKDQLK-LQEKDIQMWKVSLQKEQARYNQLQEQRD 718 QH + N + + +AA +E A +K ++EK+ + + + ++A L E D Sbjct: 625 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 684 Query: 719 TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLS 778 T+ ++I+ + + LQ K + +I +LK K+ + L Sbjct: 685 TLNKLQEAEIK---------VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 735 Query: 779 QVSQKLSNSESVQQQMEFLNRQLLVLG-----------------EVNELYLEQLQNKHSD 821 S+ S + ++QQ+E +Q+ L + EL L LQ + Sbjct: 736 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ----E 791 Query: 822 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL-------LLE 874 EV +K KEL+ + + ++ + Q+ + E + L +K+ L + Sbjct: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 851 Query: 875 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE---K 931 ++ L D++ + R + + E +A++++ EI+ + G + L K+ +E K Sbjct: 852 LRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKMSG--DNSSQLTKMNDELRLK 908 Query: 932 AEAAEAAEERLDCCNDGCS 950 E + +L N+ S Sbjct: 909 ERDVEELQLKLTKANENAS 927 Score = 32.0 bits (71), Expect = 3.3 Identities = 44/228 (19%), Positives = 94/228 (41%), Gaps = 20/228 (8%) Query: 743 QELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLL 802 + L+ K + ++AE +E + H + +++ + ++E QL Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414 Query: 803 VLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-LEKNRSHVLQQTQRLDTSQKRILEL 861 + E + +L N+ + ++VE ++ +E + K V +++ RI+EL Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK-----SRIMEL 469 Query: 862 ESHLAKKDHLLLEQKKYLE--------DVKLQARGQLQAAESRYEAQKRITQVFELEILD 913 E LA + + E ++ LE D+ L ++ + + + E + Q EI Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ---REITS 526 Query: 914 LYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEAS 961 L E G ++ +++ +A A E+L N+ + N+E S Sbjct: 527 L---KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 61.6 bits (148), Expect = 4e-09 Identities = 68/326 (20%), Positives = 143/326 (43%), Gaps = 31/326 (9%) Query: 631 SPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALR----NRRLLRKVIKAAALEEHNAAMK 686 S E++ LR QL Q+ + ++ + + R L + +K L+E+ + + Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 832 Query: 687 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 746 + EK++Q+ K + +Q V KLH + E+F S +L+ Sbjct: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK-------EEQFNMLSSDLE 885 Query: 747 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 806 E+ +M A+ R + ++ + E L + +++ + S Q+ +N +L Sbjct: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL----R 941 Query: 807 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLA 866 + E +E+LQ K + + ++ + K + ++ + +K + S L Sbjct: 942 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001 Query: 867 KKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-----EKD 921 KK + + + +L+AR + +E++ + ++ I Q + +LD +L E Sbjct: 1002 KK-----METSHNQCQELKARYERATSETKTKHEE-ILQNLQKTLLDTEDKLKGAREENS 1055 Query: 922 GLLKKLEE-----EKAEAAEAAEERL 942 GLL++LEE +KA+AA+ AE+ + Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAM 1081 Score = 60.1 bits (144), Expect = 1e-08 Identities = 65/318 (20%), Positives = 139/318 (43%), Gaps = 24/318 (7%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA----MKDQL 689 S ++ LR+ L + + + + +Q +L + + + N++ M D+L Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940 Query: 690 KLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQ----IRQLQHDREEFYNQSQEL 745 +L+E+D++ ++ L K + LQ+ + M K ++ + +++E + +L Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000 Query: 746 QTKLEDCRNMIAELRIELKKANN--KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLV 803 + K+E N EL+ ++A + K H E+L + L + ++ E + Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGL 1057 Query: 804 LGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKE-------LEKNRSHVLQQTQRLDTSQK 856 L E+ EL + + K + T ++ + KE LE + + LDT ++ Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117 Query: 857 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG 916 L+ L K LL + + +E+ + + QAA + + Q Q +++ + G Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ-QLSALQEENVKLAEELG 1176 Query: 917 RLEKDGLL--KKLEEEKA 932 R +D + +KLEEE++ Sbjct: 1177 R-SRDEVTSHQKLEEERS 1193 Score = 43.9 bits (102), Expect = 9e-04 Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 44/319 (13%) Query: 660 QHALRNRRLLRKVIKAAALEEHNAAMKDQLK-LQEKDIQMWKVSLQKEQARYNQLQEQRD 718 QH + N + + +AA +E A +K ++EK+ + + + ++A L E D Sbjct: 660 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719 Query: 719 TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLS 778 T+ ++I+ + + LQ K + +I +LK K+ + L Sbjct: 720 TLNKLQEAEIK---------VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770 Query: 779 QVSQKLSNSESVQQQMEFLNRQLLVLG-----------------EVNELYLEQLQNKHSD 821 S+ S + ++QQ+E +Q+ L + EL L LQ + Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ----E 826 Query: 822 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL-------LLE 874 EV +K KEL+ + + ++ + Q+ + E + L +K+ L + Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886 Query: 875 QKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE---K 931 ++ L D++ + R + + E +A++++ EI+ + G + L K+ +E K Sbjct: 887 LRENLADMEAKFREKDEREEQLIKAKEKLENDI-AEIMKMSG--DNSSQLTKMNDELRLK 943 Query: 932 AEAAEAAEERLDCCNDGCS 950 E + +L N+ S Sbjct: 944 ERDVEELQLKLTKANENAS 962 Score = 39.7 bits (91), Expect = 0.016 Identities = 82/391 (20%), Positives = 150/391 (38%), Gaps = 83/391 (21%) Query: 588 GVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLL 647 G PST+P + +++ S L + P S + S S RT Sbjct: 282 GFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRT-------- 333 Query: 648 HNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQ 707 LL E + R RK+ AL+E +L+++Q Sbjct: 334 --GLLTET---------SSRYARKISGTTALQE---------------------ALKEKQ 361 Query: 708 ARYNQLQEQRD---TMVTKLHSQIRQLQHD----REEFYNQSQELQTKLEDCRNMIAELR 760 QL +RD V K S + +++ + R+ EL+ K++ R M+ Sbjct: 362 QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421 Query: 761 IELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVN-ELYLEQLQNKH 819 E + LL+Q+ ++ E +Q ++E + + G++ + LE + K Sbjct: 422 REKVE----------LLNQLEEEKRKVEDLQFRVE---EESITKGDLETQTKLEHARIKE 468 Query: 820 SDTTKEVEMMKA-AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKY 878 + + E KA ++ELE R + + + RI+ELE LA + + E ++ Sbjct: 469 LEQSLLFEKTKADKLQRELEDTRVATVSE-------KSRIMELEKDLALRVQEVAELRRR 521 Query: 879 LE--------DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEE 930 LE D+ L ++ + + + E + Q EI L E G ++ ++ Sbjct: 522 LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ---REITSL---KEHFGAREETHQK 575 Query: 931 KAEAAEAAEERLDCCNDGCSDSMVGHNEEAS 961 + +A A E+L N+ + N+E S Sbjct: 576 EIKALYTATEKLSKENESLKSKLEHANKENS 606 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 61.6 bits (148), Expect = 4e-09 Identities = 105/469 (22%), Positives = 199/469 (42%), Gaps = 46/469 (9%) Query: 571 RKTEELLKKAKGNTEEDGVPSTSPME-VLDRLIQQGADAHSKELNKLPLPSKSVDWTHFG 629 R EE L+ AK E + ME ++ G + H E +K L + V+ Sbjct: 1490 RALEEALE-AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL-EQQVEEMRTQ 1547 Query: 630 GSPPSDEIRTLRDQLLLL--HNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKD 687 DE++ D L L + Q + +F+R + +K + + E A ++D Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607 Query: 688 QLKLQEKDIQMWK---VSLQKEQARYNQLQEQRDTMVT---KLHSQIRQLQHD------- 734 + K + + K + L+ +A+ + RD ++ KL +Q++ Q + Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667 Query: 735 REEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES----- 789 R+E + QS+E + KL+ I +L+ EL + H E +++ +++NS S Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727 Query: 790 --VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA--AYRKELEKNRSHVL 845 ++++E QL E + +E L ++ TT +V+ + A A + + + Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787 Query: 846 QQTQRLDTSQK-RILELESHLAKKDHL---LLEQK--KYLEDVKLQARGQLQAAESRYEA 899 QQ +R + K ++ ELE + K LE K + E ++ +A+ + A + Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847 Query: 900 QKRITQVF-----ELEILDLY-GRLEK-DGLLKKLE------EEKAEAAEAAEERLDCCN 946 +K++ ++F E D Y ++EK + +K+L+ EE+A A A+ +L Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907 Query: 947 DGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELS 995 D +++ G + E S + P S S R +S ELS Sbjct: 1908 DDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956 Score = 57.8 bits (138), Expect = 6e-08 Identities = 67/339 (19%), Positives = 146/339 (43%), Gaps = 42/339 (12%) Query: 641 RDQLLLLHNQLLYERFKRQQHALRNRRLLRKVI--KAAALEEHNAAMKDQLKLQEKDIQM 698 + Q LL +L E+ + + +R + K LEE ++ +++ +E+ Q+ Sbjct: 881 KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940 Query: 699 WKVSLQKEQARYNQLQEQRD-----------------TMVTKLHSQIRQLQHDREEFYNQ 741 + +K QA L+EQ D + K+ +I L+ +F + Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000 Query: 742 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 801 + ++ ++ +C + +AE + K E+++S + ++L E +Q++E R+L Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060 Query: 802 LVLGEVNEL--YLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 859 GE +L + +LQ + E+++ A +EL+ + +T + + K + Sbjct: 1061 --DGETTDLQDQIAELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114 Query: 860 ELESHLAKKDHLLLEQKKYLEDVKLQARG---QLQAAESRYE-------AQKRITQVFEL 909 EL++ +A+ +K + Q R +L+A ++ E AQ+ + E Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174 Query: 910 EILDLYGRLEK-----DGLLKKLEEEKAEAAEAAEERLD 943 E+ +L LE+ + ++ + + A A E E+L+ Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213 Score = 57.4 bits (137), Expect = 7e-08 Identities = 74/340 (21%), Positives = 145/340 (42%), Gaps = 41/340 (12%) Query: 636 EIRTLRDQLLLLHNQLLYERFK---------RQQHALRNRRLLRKVIKAAALEEHNAAMK 686 E+RT R+Q + + L E K RQ+HA L ++ +A + + K Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226 Query: 687 DQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQ 746 L+ K++ LQ+ +A +++ D V +LH+++ + R E ++ +LQ Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286 Query: 747 TKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGE 806 +L++ ++ E + K E L + L E +Q++ +R + E Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLNLSSRIRQLEEE 1344 Query: 807 VNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHV---LQQTQRLDTSQKRILELES 863 N L++ Q + + K +E A + +L + V L + L+ ++K++L+ Sbjct: 1345 KNS--LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402 Query: 864 HLAKKDHLLLEQK---------------KYLEDVKLQARGQLQAAESRYEAQKRITQVF- 907 L+++ LE+K + L+D+ + Q Q A + + QK+ Q+ Sbjct: 1403 ALSQR----LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458 Query: 908 -ELEILDLYGRLEKDGLLKKLEEEKAEA---AEAAEERLD 943 E I Y E+D + E++ +A A A EE L+ Sbjct: 1459 EEKSISARYAE-ERDRAEAEAREKETKALSLARALEEALE 1497 Score = 48.5 bits (114), Expect = 3e-05 Identities = 72/332 (21%), Positives = 146/332 (43%), Gaps = 39/332 (11%) Query: 635 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA----LEEHNAAMKDQLK 690 +E + ++ + L QL E RQ+ L K+ K LE+ N+ + K Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002 Query: 691 LQEKDIQMWKVSLQKEQARYNQL---QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQT 747 L E I L +E+ + L + +++ M++ L ++++ + R+E ++L Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062 Query: 748 KLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEV 807 + D ++ IAEL+ ++ + ++ E L Q + + E++ + N L V+ E Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEEL-QGALARGDDETLHK-----NNALKVVRE- 1115 Query: 808 NELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL----ES 863 LQ + ++ ++ E KA+ R + EK + + ++ + L T + L+ + Sbjct: 1116 -------LQAQIAELQEDFESEKAS-RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167 Query: 864 HLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRY-----EAQKRITQV--FELEILDLYG 916 K++ + E KK LE+ Q+Q R+ E +++ Q F+ + Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227 Query: 917 RLEKDGL-----LKKLEEEKAEAAEAAEERLD 943 LE D +K L++ KAE +E ++LD Sbjct: 1228 GLETDNKELACEVKVLQQVKAE-SEHKRKKLD 1258 Score = 46.2 bits (108), Expect = 2e-04 Identities = 81/399 (20%), Positives = 161/399 (40%), Gaps = 59/399 (14%) Query: 586 EDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLL 645 +D + + +E + + + A+A S+ L + L ++ T D++ D Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD--- 1437 Query: 646 LLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQK 705 H + + +++Q K I A EE + A + + +EK+ + ++ Sbjct: 1438 --HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA---EAEAREKETKALSLARAL 1492 Query: 706 EQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKK 765 E+A + +E+ + +L + + L +++ EL+ + E+R +L++ Sbjct: 1493 EEAL--EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550 Query: 766 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNE----LYLEQLQNKHSD 821 +++ TE KL ++Q R L E NE L ++Q++ ++ Sbjct: 1551 LEDELQATE------DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604 Query: 822 TTKEVEM--MKAAYRKELE--------------KNRSHVLQQTQRLDTSQKRI-LELESH 864 E + + A +K++E K R V++Q ++L K ELE Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664 Query: 865 LAKKDHLLLEQK------KYLEDVKLQARGQLQAAE--SRYEAQKRITQVFEL------- 909 A +D + + K K LE LQ + +L ++E R+ Q+R E+ Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724 Query: 910 -EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCND 947 +LD RLE + +LEEE E + ++ ND Sbjct: 1725 SALLDEKRRLE--ARIAQLEEE----LEEEQSNMELLND 1757 >gi|102467235 inner centromere protein antigens 135/155kDa isoform 1 [Homo sapiens] Length = 918 Score = 61.6 bits (148), Expect = 4e-09 Identities = 73/347 (21%), Positives = 152/347 (43%), Gaps = 24/347 (6%) Query: 632 PPSDEIRTLRDQL-LLLHNQLLYERFKRQQHALRN----RRLLRKVIKAAALEEHNAAMK 686 P S +R LR L + NQ+L + +++ LR K + +E+ ++ Sbjct: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLE 543 Query: 687 DQLKLQEKD-IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL 745 + + +E + ++ KV K + R +++ +R+ + K+ +++ +EE Q ++ Sbjct: 544 NLRRKEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK 602 Query: 746 QTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLG 805 ++++ E R+ +KA K ++K+ E+ ++Q E R + Sbjct: 603 FAQIDEKTEKAKEERLAEEKAKKKAA---------AKKMEEVEARRKQEEEARRLRWLQQ 653 Query: 806 EVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHL 865 E E ++L K + +E + KAA K L + R ++ +R + ++ E Sbjct: 654 EEEERRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712 Query: 866 AKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGL-- 923 +++ L EQ++ E +LQA +LQ E QK + + E+ + + E+ L Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQK---EQLQRELEEKKKKEEQQRLAE 769 Query: 924 --LKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETK 968 L++ +E+KA+ A A + L+ D S + + GH K Sbjct: 770 RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPK 816 >gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] Length = 625 Score = 61.2 bits (147), Expect = 5e-09 Identities = 88/390 (22%), Positives = 163/390 (41%), Gaps = 49/390 (12%) Query: 569 VIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHF 628 V+ E+L+ + EED S + + + + + KE K S+ Sbjct: 70 VLLSENEMLQAKLHSQEEDFRLQNSTL-----MAEFSKERYGKEAGKFSAVSEGQ----- 119 Query: 629 GGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ 688 G PP T+ + L +L +E K ++ L + + ++++ E + ++ Sbjct: 120 -GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL---QGLESSKQAETSRLQEEL 175 Query: 689 LKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQE 744 KL EK L+K+Q + +LQ +++T+ ++I +LQ +E + ++Q+ Sbjct: 176 AKLSEK--------LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK 227 Query: 745 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQME-------FL 797 LQ +LE +AELR + + ++ H L + Q S Q+Q+E L Sbjct: 228 LQQELEAANQSLAELRDQ--RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285 Query: 798 NRQLLVLGEVNELYLEQLQNKHSDTT---KEVEMMKAAYRKELEKNRSHVLQQTQRLDTS 854 L L ++ ++L TT E++ +A Y ++L + + Q Q + Sbjct: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY-EDLMGQKDDLNSQLQESLRA 344 Query: 855 QKRILE-LESHLAKKDHL---LLEQKKYLEDVKLQ----ARGQLQAAESRYEAQKRITQV 906 R+LE L+ +K+ L L E +K E K A LQ E + Sbjct: 345 NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLR 404 Query: 907 FELEILDLYGRLEKDGLLKKLEEEKAEAAE 936 E E+L + R E++ L++L E+K E Sbjct: 405 HEKEVLGVRARYERE--LRELHEDKKRQEE 432 Score = 61.2 bits (147), Expect = 5e-09 Identities = 76/322 (23%), Positives = 134/322 (41%), Gaps = 41/322 (12%) Query: 637 IRTLRDQLLL--LHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 694 +R L+DQ+ + Q E + +ALR AALE+ A +L + + Sbjct: 257 LRALQDQVSIQSADAQEQVEGLLAENNALRT--------SLAALEQIQTAKTQELNMLRE 308 Query: 695 DIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRN 754 LQ++QA Y L Q+D L+SQ+++ Q QE+ + E Sbjct: 309 QTTGLAAELQQQQAEYEDLMGQKD----DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 364 Query: 755 MIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ 814 + E R +K K EL + + +K + E + L + VLG V Y + Sbjct: 365 ELQEARKSAEK--RKAMLDELAMETLQEKSQHKEELGAVR--LRHEKEVLG-VRARYERE 419 Query: 815 LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKD----- 869 L+ H D ++ E ++ R+E + T+ L+T Q+ + EL++ + D Sbjct: 420 LRELHEDKKRQEEELRGQIREEKAR--------TRELETLQQTVEELQAQVHSMDGAKGW 471 Query: 870 -HLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGR---LEKDG--L 923 L++ + E+ R QL+ A+ + + + E+ D LEK G Sbjct: 472 FERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA 531 Query: 924 LKKLEEE---KAEAAEAAEERL 942 LK L+ + + + A+ +ERL Sbjct: 532 LKDLKRQLHLERKRADKLQERL 553 >gi|102467242 inner centromere protein antigens 135/155kDa isoform 2 [Homo sapiens] Length = 914 Score = 60.5 bits (145), Expect = 9e-09 Identities = 70/343 (20%), Positives = 149/343 (43%), Gaps = 20/343 (5%) Query: 632 PPSDEIRTLRDQL-LLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK 690 P S +R LR L + NQ+L + +++ ++ E+ +++ + Sbjct: 484 PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRR 543 Query: 691 LQEKD-IQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKL 749 +E + ++ KV K + R +++ +R+ + K+ +++ +EE Q ++ ++ Sbjct: 544 KEEAEQLRRQKVEEDKRR-RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602 Query: 750 EDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNE 809 ++ E R+ +KA K ++K+ E+ ++Q E R + E E Sbjct: 603 DEKTEKAKEERLAEEKAKKKAA---------AKKMEEVEARRKQEEEARRLRWLQQEEEE 653 Query: 810 LYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKD 869 ++L K + +E + KAA K L + R ++ +R + ++ E +++ Sbjct: 654 RRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE 712 Query: 870 HLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGL----LK 925 L EQ++ E +LQA +LQ E QK + + E+ + + E+ L L+ Sbjct: 713 RQLAEQERRREQERLQAERELQEREKALRLQK---EQLQRELEEKKKKEEQQRLAERQLQ 769 Query: 926 KLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETK 968 + +E+KA+ A A + L+ D S + + GH K Sbjct: 770 EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPK 812 >gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sapiens] Length = 693 Score = 60.1 bits (144), Expect = 1e-08 Identities = 73/345 (21%), Positives = 155/345 (44%), Gaps = 38/345 (11%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 713 +R + A+ RRL + + + A L H + + LK + + + ++ E+AR+ + Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE- 245 Query: 714 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAE--------LRIELKK 765 + K+ + R L+ +++ ++ QEL+ L + +N +AE + +++ Sbjct: 246 ------RMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQ 299 Query: 766 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR-QLLVLGEVNELYLEQLQNKHSDTTK 824 ++ H + + KL + Q + L++ Q L E E+ EQ + + + Sbjct: 300 LQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQER 359 Query: 825 EVEMMKAA--YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL--E 880 E + +K L++ + +Q QRL ++R+ + E L K++ L +Q++ L + Sbjct: 360 LCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKK 419 Query: 881 DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG------RLEKD--GLLKKLEEEKA 932 + +LQ + + A ++ K++ + + DL +LE+ L +KL+EE Sbjct: 420 EERLQKQEERLALSQNHKLDKQLAEP-QCSFEDLNNEKKSALQLEQQVKELQEKLDEEHL 478 Query: 933 EAAEAAEERLDCCNDGCSDSMVGHNEEASG----HNGETKTPRPS 973 EAA ++L+ S+V E G + E + PRP+ Sbjct: 479 EAASQRNQQLE-----TQLSLVALPGEGDGGQHLDSEEEEAPRPT 518 Score = 36.6 bits (83), Expect = 0.14 Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 33/262 (12%) Query: 680 EHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 739 E+N A+ K Q++ +Q + L++++A+ + QE+ +L Q + LQ E Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLR 382 Query: 740 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 799 Q Q L+ + E L+K ++ E L ++L E Q+ E Sbjct: 383 KQEQRLRKQEE-----------RLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE---- 427 Query: 800 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 859 + L L + ++L K++ + ++ ++L + LQ Q++ Q+++ Sbjct: 428 ERLALSQNHKL------------DKQLAEPQCSF-EDLNNEKKSALQLEQQVKELQEKLD 474 Query: 860 ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 919 E A + + LE + L + + G EA + + E DL R E Sbjct: 475 EEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPE----DLESR-E 529 Query: 920 KDGLLKKLEEEKAEAAEAAEER 941 L +EKA+ E E R Sbjct: 530 ATSSFMDLPKEKADGTEQVERR 551 Score = 35.4 bits (80), Expect = 0.30 Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 42/309 (13%) Query: 635 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ---LKL 691 ++ + L++Q +L Q +R + Q+ LR+ K L+E ++ Q L+ Sbjct: 334 EQKQRLQEQEEMLREQEA-QRVREQERLCEQNERLREQQKT--LQEQGERLRKQEQRLRK 390 Query: 692 QEKDIQMWKVSLQKEQARY-----------NQLQEQRDTMVT----KLHSQIRQLQHDRE 736 QE+ ++ + LQK++ R +LQ+Q + + KL Q+ + Q E Sbjct: 391 QEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFE 450 Query: 737 EFYNQSQ---ELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ 793 + N+ + +L+ ++++ + + E +E N+ T+L L + + + + + Sbjct: 451 DLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSE 510 Query: 794 MEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 853 E R + E +L + + D KE KA +++E+ +Q + D Sbjct: 511 EEEAPRPTPNIPE--DLESREATSSFMDLPKE----KADGTEQVERRELGFVQPSGVTDG 564 Query: 854 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 913 ++ ES A + + + +EDV ++ A+ E + ++ ++ EL +L Sbjct: 565 MRESFTVYESQGAVPN----TRHQEMEDV-------IRLAQKEEEMKVKLLELQEL-VLP 612 Query: 914 LYGRLEKDG 922 L G E G Sbjct: 613 LVGNHEGHG 621 >gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C isoform 1 [Homo sapiens] Length = 693 Score = 60.1 bits (144), Expect = 1e-08 Identities = 73/345 (21%), Positives = 155/345 (44%), Gaps = 38/345 (11%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 713 +R + A+ RRL + + + A L H + + LK + + + ++ E+AR+ + Sbjct: 187 DRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQE- 245 Query: 714 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAE--------LRIELKK 765 + K+ + R L+ +++ ++ QEL+ L + +N +AE + +++ Sbjct: 246 ------RMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQ 299 Query: 766 ANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR-QLLVLGEVNELYLEQLQNKHSDTTK 824 ++ H + + KL + Q + L++ Q L E E+ EQ + + + Sbjct: 300 LQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQER 359 Query: 825 EVEMMKAA--YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL--E 880 E + +K L++ + +Q QRL ++R+ + E L K++ L +Q++ L + Sbjct: 360 LCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKK 419 Query: 881 DVKLQARGQLQAAESRYEAQKRITQVFELEILDLYG------RLEKD--GLLKKLEEEKA 932 + +LQ + + A ++ K++ + + DL +LE+ L +KL+EE Sbjct: 420 EERLQKQEERLALSQNHKLDKQLAEP-QCSFEDLNNEKKSALQLEQQVKELQEKLDEEHL 478 Query: 933 EAAEAAEERLDCCNDGCSDSMVGHNEEASG----HNGETKTPRPS 973 EAA ++L+ S+V E G + E + PRP+ Sbjct: 479 EAASQRNQQLE-----TQLSLVALPGEGDGGQHLDSEEEEAPRPT 518 Score = 36.6 bits (83), Expect = 0.14 Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 33/262 (12%) Query: 680 EHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFY 739 E+N A+ K Q++ +Q + L++++A+ + QE+ +L Q + LQ E Sbjct: 323 ENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLR 382 Query: 740 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 799 Q Q L+ + E L+K ++ E L ++L E Q+ E Sbjct: 383 KQEQRLRKQEE-----------RLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE---- 427 Query: 800 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 859 + L L + ++L K++ + ++ ++L + LQ Q++ Q+++ Sbjct: 428 ERLALSQNHKL------------DKQLAEPQCSF-EDLNNEKKSALQLEQQVKELQEKLD 474 Query: 860 ELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 919 E A + + LE + L + + G EA + + E DL R E Sbjct: 475 EEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPE----DLESR-E 529 Query: 920 KDGLLKKLEEEKAEAAEAAEER 941 L +EKA+ E E R Sbjct: 530 ATSSFMDLPKEKADGTEQVERR 551 Score = 35.4 bits (80), Expect = 0.30 Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 42/309 (13%) Query: 635 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQ---LKL 691 ++ + L++Q +L Q +R + Q+ LR+ K L+E ++ Q L+ Sbjct: 334 EQKQRLQEQEEMLREQEA-QRVREQERLCEQNERLREQQKT--LQEQGERLRKQEQRLRK 390 Query: 692 QEKDIQMWKVSLQKEQARY-----------NQLQEQRDTMVT----KLHSQIRQLQHDRE 736 QE+ ++ + LQK++ R +LQ+Q + + KL Q+ + Q E Sbjct: 391 QEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFE 450 Query: 737 EFYNQSQ---ELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQ 793 + N+ + +L+ ++++ + + E +E N+ T+L L + + + + + Sbjct: 451 DLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSE 510 Query: 794 MEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDT 853 E R + E +L + + D KE KA +++E+ +Q + D Sbjct: 511 EEEAPRPTPNIPE--DLESREATSSFMDLPKE----KADGTEQVERRELGFVQPSGVTDG 564 Query: 854 SQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILD 913 ++ ES A + + + +EDV ++ A+ E + ++ ++ EL +L Sbjct: 565 MRESFTVYESQGAVPN----TRHQEMEDV-------IRLAQKEEEMKVKLLELQEL-VLP 612 Query: 914 LYGRLEKDG 922 L G E G Sbjct: 613 LVGNHEGHG 621 >gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens] Length = 570 Score = 59.7 bits (143), Expect = 2e-08 Identities = 84/428 (19%), Positives = 185/428 (43%), Gaps = 50/428 (11%) Query: 551 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 609 P + HL P H ++ K K A+ + D P T+P + +D Sbjct: 22 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 74 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 K++N P + T G P DE + H + L + Q +R Sbjct: 75 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVQTIRILTCQ 126 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 711 + ++ A +A QL+ + +D+ WK + + EQA RY Sbjct: 127 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 184 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 +L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+ Sbjct: 185 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 240 Query: 772 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 831 +LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++ Sbjct: 241 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 891 K +++ + +Q +++ ++ + E E + +++ ++ E+++ + +++ + Q + Sbjct: 300 REEK-IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 358 Query: 892 AAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSD 951 E + Q+ E +I + R E++ + + EE+ E E E+ + + + Sbjct: 359 IREQEEKRQE------EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE--QE 410 Query: 952 SMVGHNEE 959 +G EE Sbjct: 411 EKMGEQEE 418 Score = 52.8 bits (125), Expect = 2e-06 Identities = 49/256 (19%), Positives = 121/256 (47%), Gaps = 20/256 (7%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 Q+++ +MW+ +K Q R ++QEQ + K+ Q +++ E + + ++++ + E Sbjct: 284 QQQEEKMWRQE-EKIQEREEKIQEQEE----KIREQEEKMRRQEEMMWEKEEKMRRQEE- 337 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVS-----QKLSNSESVQQQMEFLNRQLLVLGE 806 M+ E ++++ K+ E + Q +K+ E Q+Q + RQ + E Sbjct: 338 ---MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394 Query: 807 VNELYLEQ--LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 864 E EQ + + + E E +E+++ + +Q +++ +K+I E E Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454 Query: 865 LAKKDHLLLEQKKYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-EK 920 + +++ ++ EQ++ + E + ++Q E + Q+ + E +I + ++ E+ Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514 Query: 921 DGLLKKLEEEKAEAAE 936 + ++++ EE+ E E Sbjct: 515 EEMMQEQEEKMWEQEE 530 Score = 52.4 bits (124), Expect = 2e-06 Identities = 40/242 (16%), Positives = 113/242 (46%), Gaps = 7/242 (2%) Query: 654 ERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 711 E+ +RQ+ + + ++ R+ EE +++++ QEK + + ++E+ R Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 + +++++ + + +IR+ + E QE + K+ + + E E+++ K+ Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435 Query: 772 HTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVLGEVNELYLEQ---LQNKHSDTTKEVE 827 E + + +K+ E +++Q E + Q +GE EQ +Q + ++ E Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495 Query: 828 MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQAR 887 ++ K++ + + +Q + + ++++ E E + +++ + EQ++ + + + R Sbjct: 496 KIR-EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554 Query: 888 GQ 889 Q Sbjct: 555 EQ 556 Score = 46.6 bits (109), Expect = 1e-04 Identities = 48/273 (17%), Positives = 119/273 (43%), Gaps = 25/273 (9%) Query: 649 NQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQA 708 NQ E+ RQ+ ++ R K EE +++++ QE+ + + +++++ Sbjct: 283 NQQQEEKMWRQEEKIQEREE-----KIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 337 Query: 709 RYNQLQEQRDTMVTKLHSQ--IRQLQHDREE-----FYNQSQELQTKLEDCRNMIAELRI 761 + +E+ + K+H Q IR+ + R+E + QE + K+ I E Sbjct: 338 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397 Query: 762 ELKKANNKVCHTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVLGEVNELYLEQ------ 814 ++++ + E + + +K+ E +Q+Q E + RQ + E + EQ Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457 Query: 815 ---LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHL 871 + + + E E ++++ + +Q +++ +K+I E E + +++ + Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517 Query: 872 LLEQKKYL---EDVKLQARGQLQAAESRYEAQK 901 + EQ++ + E+ + ++Q E + Q+ Sbjct: 518 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550 >gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 668 Score = 59.3 bits (142), Expect = 2e-08 Identities = 86/424 (20%), Positives = 184/424 (43%), Gaps = 55/424 (12%) Query: 551 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 609 P + HL P H ++ K K A+ + D P T+P + +D Sbjct: 34 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 86 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 K++N P + T G P DE + H + L + Q H +R Sbjct: 87 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 138 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 711 + ++ A +A QL+ + +D+ WK + + EQA RY Sbjct: 139 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 196 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 +L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+ Sbjct: 197 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252 Query: 772 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY--LEQLQN----KHSDTTKE 825 +LLL Q Q + ++ + ++++ ++ +L E NEL+ L Q Q + + +E Sbjct: 253 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311 Query: 826 VEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQK---KYLEDV 882 E +++ + + +Q +++ ++ + E E + +++ ++ E++ + LE++ Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371 Query: 883 KLQARGQLQAAESRYEAQKRITQVFEL-----EILDLYGRLEKDGLLKKLEEEKAEAAEA 937 + +++ E + Q++I + E +I + R E++ + + EE+ E E Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431 Query: 938 AEER 941 E+ Sbjct: 432 IREQ 435 Score = 48.1 bits (113), Expect = 5e-05 Identities = 35/222 (15%), Positives = 99/222 (44%), Gaps = 39/222 (17%) Query: 682 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 741 N ++++ QE+ IQ W+ +Q+++ + + +E K+ Q +++ E + + Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-------KIREQEEKMRRQEEMMWEK 347 Query: 742 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 801 ++++ + E M+ E ++++ + E + ++ +K+ E +++Q E Sbjct: 348 EEKMRRQEE----MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE------ 397 Query: 802 LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL 861 K E K +++ ++ + + +Q +++ +++I E Sbjct: 398 ----------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 435 Query: 862 ESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 903 E + +++ + EQ+K E+ K Q + ++ E + Q+ I Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 477 Score = 48.1 bits (113), Expect = 5e-05 Identities = 42/233 (18%), Positives = 108/233 (46%), Gaps = 18/233 (7%) Query: 658 RQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQK-EQARYNQLQEQ 716 RQ+ + + +R+ K EE + + K++E++ ++W+ + EQ + + +E+ Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEE---MWRQEEKIREQE-EIWRQKEKMHEQEKIRKQEEK 496 Query: 717 RDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELL 776 K+H Q +++ E+ + Q ++++ + E R E ++++ + E Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR----EQEEKIREQEEMMQEQEEK 552 Query: 777 LSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQ---LQNKHSDTTKEVEMMKAAY 833 + + +K+ E +++Q E + Q + E E EQ + + ++ EMM+ Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612 Query: 834 RKELE------KNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLE 880 K E + + +Q +++ ++++ E E L +++ + E +++LE Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665 Score = 43.5 bits (101), Expect = 0.001 Identities = 38/296 (12%), Positives = 132/296 (44%), Gaps = 25/296 (8%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 713 E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++ Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRLEEM 371 Query: 714 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 769 +++ + +L ++ + + RE+ + +E Q K ++ + ++++ K Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431 Query: 770 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK 824 + E + + +K+ E + +Q+ E + RQ + E E++ ++ + + + Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491 Query: 825 EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKL 884 + E +++ + +Q +++ +++I E E + +++ + EQ++ +++ + Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551 Query: 885 QARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEE 940 + Q + + + + +++ ++ E E +K+ E+K + E E+ Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQE--------------EKIREQKEKIREQEEK 593 Score = 38.5 bits (88), Expect = 0.036 Identities = 27/152 (17%), Positives = 71/152 (46%), Gaps = 6/152 (3%) Query: 654 ERFKRQQHALRNR--RLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYN 711 E+ Q+ +R + ++ R+ K EE +++++ QE+ +Q + + +++ + Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL---QTKLEDCRNMIAELRIELKKANN 768 + QE+ K+ Q +++ +E+ Q +++ + K+ + M+ E ++ + Sbjct: 562 E-QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620 Query: 769 KVCHTELLLSQVSQKLSNSESVQQQMEFLNRQ 800 K+C E + + +K+ E + E RQ Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652 >gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 724 Score = 59.3 bits (142), Expect = 2e-08 Identities = 57/316 (18%), Positives = 147/316 (46%), Gaps = 23/316 (7%) Query: 635 DEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEK 694 +E+ +++ + ++++E+ ++ + K+ + + +++Q K QE+ Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475 Query: 695 DIQMWKVSLQKEQARYNQLQEQRDTM---VTKLHSQIR----QLQHDREEFYNQSQELQT 747 + +MW+ +K + + +++EQ + M K+H Q + + + ++EE + Q ++++ Sbjct: 476 EAKMWRQE-EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534 Query: 748 KLEDCRNM--IAELRIELKKANNKVCHTELLLSQVSQKL-SNSESVQQQMEFLNRQLLVL 804 + E R I E +++K K+ E + +K+ E V +Q E + Q + Sbjct: 535 QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKI 594 Query: 805 GEVNELYLEQ--LQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELE 862 E E EQ + + + E E +++++ + +Q +++ +K+I E E Sbjct: 595 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE 654 Query: 863 SHLAKKDHLLLEQKKYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLE 919 + +++ ++ EQ++ + E+ + ++Q E + Q+ +++E E+ RL Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEV-----RLR 707 Query: 920 KDGLLKKLEEEKAEAA 935 + + +E EAA Sbjct: 708 QQEEKMQEHQEHLEAA 723 Score = 58.5 bits (140), Expect = 3e-08 Identities = 83/410 (20%), Positives = 181/410 (44%), Gaps = 48/410 (11%) Query: 551 PPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTE-EDGVPSTSPMEVLDRLIQQGADAH 609 P + HL P H ++ K K A+ + D P T+P + +D Sbjct: 95 PTHPHL--PTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPS-----VGTAASDTK 147 Query: 610 SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL 669 K++N P + T G P DE + H + L + Q H +R Sbjct: 148 KKKINNGTNPETT---TSGGCHSPEDEQKASHQ-----HQEALRRELEAQVHTIRILTCQ 199 Query: 670 RKVIKAAALEEHNAAMKDQLKLQEKDI-----QMWKVSLQKEQA------------RY-N 711 + ++ A +A QL+ + +D+ WK + + EQA RY Sbjct: 200 KTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE 257 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 +L ++RD + +L+ R D EE ++ +LQ KL+ + +E+++ +K+ K+ Sbjct: 258 ELTKERDALSLELY---RNTITD-EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 313 Query: 772 HTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKA 831 +LLL Q Q + ++ + ++++ ++ +L E NEL+ Q + ++ E ++ Sbjct: 314 RAKLLLPQ-QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ- 371 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQ 891 + +++++ + +Q +++ ++++ E + +K+ + Q++ + + + + R Q Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-- 429 Query: 892 AAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEER 941 E +E +++I ++ E R +++ K+ EEEK E +E+ Sbjct: 430 -EEMMWEKEEKIRELEEKMHEQEKIREQEE---KRQEEEKIREQEKRQEQ 475 Score = 48.1 bits (113), Expect = 5e-05 Identities = 35/222 (15%), Positives = 99/222 (44%), Gaps = 39/222 (17%) Query: 682 NAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQ 741 N ++++ QE+ IQ W+ +Q+++ + + +E K+ Q +++ E + + Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-------KIREQEEKMRRQEEMMWEK 408 Query: 742 SQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQL 801 ++++ + E M+ E ++++ + E + ++ +K+ E +++Q E Sbjct: 409 EEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE------ 458 Query: 802 LVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILEL 861 K E K +++ ++ + + +Q +++ +++I E Sbjct: 459 ----------------------KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496 Query: 862 ESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRI 903 E + +++ + EQ+K E+ K Q + ++ E + Q+ I Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 538 Score = 44.3 bits (103), Expect = 7e-04 Identities = 46/304 (15%), Positives = 137/304 (45%), Gaps = 23/304 (7%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQL 713 E+ + Q+ +R + + + + + + K++ ++ MW+ +++ R ++ Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEM 432 Query: 714 QEQRDTMVTKLHSQIRQLQHDREEFYNQSQEL----QTKLEDCRNMIAELRIELKKANNK 769 +++ + +L ++ + + RE+ + +E Q K ++ + ++++ K Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492 Query: 770 VCHTELLLSQVSQKLSNSESV-----QQQMEFLNRQLLVLGEVNELY--LEQLQNKHSDT 822 + E + + +K+ E + +Q+ E + RQ + E E++ E++ + Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552 Query: 823 TKEVEMMKAAYRK------ELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQK 876 K+ E M K ++ + V +Q +++ +++I E E + +++ + EQ+ Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612 Query: 877 KYL---EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRL-EKDGLLKKLEEEKA 932 + + E+ + ++Q E + Q+ + E +I + ++ E++ ++++ EE+ Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672 Query: 933 EAAE 936 E E Sbjct: 673 EQEE 676 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2345 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2521 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2573 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1732 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1733 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1783 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1784 KSKQRLE 1790 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2089 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2090 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2209 LQRLKAEATEAARQR 2223 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2531 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2532 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2578 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2579 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2615 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1669 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1713 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1714 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1822 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1823 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1225 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1226 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1261 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1381 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1382 --AKAQAEREAKELQQRMQEEVVRREEAA 1408 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2349 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2525 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2577 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1736 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1737 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1787 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1788 KSKQRLE 1794 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2093 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2094 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2213 LQRLKAEATEAARQR 2227 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2535 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2536 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2582 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2583 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2619 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1617 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1673 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1717 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1718 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1826 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1827 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1229 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1230 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1265 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1266 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1325 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1326 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1385 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1386 --AKAQAEREAKELQQRMQEEVVRREEAA 1412 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2345 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2521 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2573 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1732 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1733 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1783 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1784 KSKQRLE 1790 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2089 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2090 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2209 LQRLKAEATEAARQR 2223 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2531 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2532 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2578 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2579 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2615 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1669 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1713 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1714 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1822 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1823 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1225 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1226 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1261 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1262 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1321 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1322 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1381 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1382 --AKAQAEREAKELQQRMQEEVVRREEAA 1408 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2313 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2489 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2541 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1700 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1701 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1751 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1752 KSKQRLE 1758 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2057 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2058 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2177 LQRLKAEATEAARQR 2191 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2499 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2500 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2546 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2547 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2583 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1581 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1637 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1681 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1682 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1790 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1791 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1193 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1194 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1229 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1230 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1289 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1290 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1349 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1350 --AKAQAEREAKELQQRMQEEVVRREEAA 1376 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2482 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2658 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2710 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1869 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1870 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1920 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1921 KSKQRLE 1927 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2226 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2227 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2346 LQRLKAEATEAARQR 2360 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2668 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2669 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2715 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2716 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2752 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1750 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1806 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1850 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1851 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1959 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1960 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1362 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1363 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1398 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1399 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1458 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1459 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1518 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1519 --AKAQAEREAKELQQRMQEEVVRREEAA 1545 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2323 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2384 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2499 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2551 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1710 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1711 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1761 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1762 KSKQRLE 1768 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2067 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2068 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2187 LQRLKAEATEAARQR 2201 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2509 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2510 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2556 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2557 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2593 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1591 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1647 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1691 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1692 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1800 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1801 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1203 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1204 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1239 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1240 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1299 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1300 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1359 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1360 --AKAQAEREAKELQQRMQEEVVRREEAA 1386 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2331 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2392 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2507 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2559 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1718 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1719 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1769 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1770 KSKQRLE 1776 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2075 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2076 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2195 LQRLKAEATEAARQR 2209 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2517 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2518 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2564 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2565 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2601 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1599 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1655 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1699 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1700 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1808 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1809 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1211 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1212 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1247 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1248 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1307 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1308 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1367 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1368 --AKAQAEREAKELQQRMQEEVVRREEAA 1394 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 59.3 bits (142), Expect = 2e-08 Identities = 65/295 (22%), Positives = 134/295 (45%), Gaps = 21/295 (7%) Query: 660 QHALRNRRLL------RKVIKAAALEEHNAAMKDQLKLQ-EKDIQMWKVSLQKEQARYNQ 712 Q A R R+L ++ + L+E A+++ +L+ E ++ + L +EQAR + Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--R 2372 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 LQE ++ M +L + + Q E + E+ + E + +AE+ +A Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-MMKA 831 ++ +KL +E Q+ L + L + + ++ E+L+ ++ +E E + + Sbjct: 2433 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492 Query: 832 AYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA----R 887 A +L+ +QQ Q L +Q +S L++KD LL++++++E K + + Sbjct: 2493 AKLLQLKSEEMQTVQQEQLLQETQAL---QQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ 2548 Query: 888 GQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERL 942 ++ A+ E Q+R Q E E L +E+ ++ + E E +E L Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEEL 2600 Score = 47.8 bits (112), Expect = 6e-05 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 30/307 (9%) Query: 654 ERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLK----LQEKDIQMWKVSLQKEQAR 709 ER +RQ R+ +V A+ ++ A +++ + L+E +Q + + QA Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583 Query: 710 YNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNK 769 + ++ + + T S +LQ R F ++ +L+ L++ +A+LR E ++ + Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643 Query: 770 VCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVE-- 827 E + ++L + + L Q + + L + + + + +E Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703 Query: 828 --------MMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYL 879 + +ELEK R Q+ +++ ++ L + + + +Q++ L Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE----QQRQLL 1759 Query: 880 EDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL---KKLEEEKAEAAE 936 E+ AR Q +AA + QKR Q E E+ + R E + LL + EEE +E Sbjct: 1760 EEE--LARLQREAAAA---TQKR--QELEAELAKV--RAEMEVLLASKARAEEESRSTSE 1810 Query: 937 AAEERLD 943 +++RL+ Sbjct: 1811 KSKQRLE 1817 Score = 46.2 bits (108), Expect = 2e-04 Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 38/315 (12%) Query: 660 QHALRNRRLLRKVIKAA-ALEEHNAAMKDQLKLQ-------EKDIQMWKVSLQKEQARYN 711 + LR RR + + I A A E AA K +L+L+ +D K + E AR Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000 Query: 712 QLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVC 771 QL + + + ++++ EE Q + ++E + + E R ++A + Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060 Query: 772 HTELLLSQVSQKLSNSE------SVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK- 824 L + +QK +E +VQQ+ + L + L + + L+QL+ + + Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL----QQEQSVLDQLRGEAEAARRA 2116 Query: 825 --EVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDV 882 E E + +E ++R V ++ +RL S + + + L ++ + Sbjct: 2117 AEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175 Query: 883 KLQARG----QLQAAESRYEAQKRITQV-------FELEILDLYGRLEKDGLLKKLEEE- 930 + QA Q QAA++ E K+ + E E+ L +LE+ K L +E Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235 Query: 931 ----KAEAAEAAEER 941 KAEA EAA +R Sbjct: 2236 LQRLKAEATEAARQR 2250 Score = 45.4 bits (106), Expect = 3e-04 Identities = 40/159 (25%), Positives = 75/159 (47%), Gaps = 18/159 (11%) Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHAL--RNRRLLRKVIKAAALEEHNAAMKDQLKL 691 S+E++T++ + LL Q L + F ++ +L R R + ++ K L + A QL+ Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR- 2558 Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 +++Q + Q++++R +V + + R+ QH+ EE + QE +LE Sbjct: 2559 ------------EEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQ 2605 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESV 790 R EL E + + +LL Q L++SE V Sbjct: 2606 QRRQQEELLAEENQRLRE--QLQLLEEQHRAALAHSEEV 2642 Score = 37.7 bits (86), Expect = 0.061 Identities = 63/292 (21%), Positives = 119/292 (40%), Gaps = 38/292 (13%) Query: 655 RFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQ 714 R ++Q A R R + ++ L+ + A +L+LQ +++ K Q E + + Sbjct: 1640 RAQQQAEAERAREEAERELERWQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQKEEA 1696 Query: 715 EQRDTMVTKLHSQ-IRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHT 773 E+ K Q +RQ + +E Q Q +AE + + A + Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQ------------LAEGTAQQRLAAEQ---- 1740 Query: 774 ELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTK---EVEMMK 830 ++ + + +E +QQ + L +L L ++ Q ++ K E+E++ Sbjct: 1741 -----ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795 Query: 831 AAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQL 890 A+ + E++RS + QRL+ R EL A+ L E K+ + + Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ------RQLAEE 1849 Query: 891 QAAESRYEAQKRITQVFELEILDLYGRL--EKDGLLKKLEEEKAEAAEAAEE 940 AA R EA++ + + +L + RL E + LK+ E E AE+ Sbjct: 1850 DAARQRAEAERVLAE--KLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899 Score = 33.9 bits (76), Expect = 0.88 Identities = 49/269 (18%), Positives = 108/269 (40%), Gaps = 52/269 (19%) Query: 692 QEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED 751 ++ +++ W+ + + R+ + Q D +L RQL++ RE + L L+D Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE----SADPLGAWLQD 1252 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 R +++ + L++S++V++Q+ RQ L E E + Sbjct: 1253 ARRRQEQIQ--------------------AMPLADSQAVREQL----RQEQALLEEIERH 1288 Query: 812 LEQLQ------NKHSDTTKEVEMMKAAYRKELE------------KNRSHVLQQTQRLDT 853 E+++ ++ + K+ E+ Y+ +LE V+Q+ L T Sbjct: 1289 GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT 1348 Query: 854 SQKRILELESH----LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL 909 + L S +++ + E+++ E + + R +L E+ E Q+++ + Sbjct: 1349 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQ 1408 Query: 910 EILDLYGRLEKDGLLKKLEEEKAEAAEAA 938 E L ++++EE EAA Sbjct: 1409 --AKAQAEREAKELQQRMQEEVVRREEAA 1435 >gi|169208018 PREDICTED: similar to Golgin subfamily A member 8-like protein 2 isoform 3 [Homo sapiens] Length = 595 Score = 58.2 bits (139), Expect = 4e-08 Identities = 75/344 (21%), Positives = 148/344 (43%), Gaps = 31/344 (9%) Query: 673 IKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTK---LHSQIR 729 +K + L+ ++K Q K E ++ K + + Q +L+ Q T++ + L++ + Sbjct: 83 VKISRLKNTIKSLKQQKKQVEHQLEEEKKANNERQKAERELEVQIQTLIIQKEELNTDLY 142 Query: 730 QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES 789 ++ F +S++L +L+ + + EL++A + V TE + S + + Sbjct: 143 HMERSLRYFEEESKDLAVRLQHS----LQCKGELERALSAVIATEKKKANQLSSCSKAHT 198 Query: 790 VQQQMEFLNRQLLVLGEVNELY--LEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQ 847 + + L Q L+ ++ +L +QLQ + + + +E +A + + + K + Sbjct: 199 EWELEQSLQDQALLKAQLTQLKESFQQLQLERDECAEHIEGERARWHQRMSKMLQEICTL 258 Query: 848 TQRLDTSQKRILELESHLAKKDHLLLEQ-----KKYLEDVKLQ-ARGQLQAAESRYEAQK 901 + +R+ ELE L+K + + E +V+LQ R +L+ ++Q Sbjct: 259 KKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQSQV 318 Query: 902 RITQVFELEILDLYGRL-EKDGLLKKLEEEKAEAAEAAEERL-------DCCNDGCS--- 950 + Q L R+ E++ L+K EE E E + + N+ S Sbjct: 319 KNNQHISLLNRRQEERIREQEERLRKQEERLQEQHEKLRQLAKPQSVFEELNNENKSTLQ 378 Query: 951 -DSMVGHNEEASGHNGETKTP---RPSSARGSSGSRGGGGSSSS 990 + V +E G ET+T P +ARG G+ G GG SSS Sbjct: 379 LEQQVKELQEKLGEVKETETSAQKEPEAARGP-GAPGPGGESSS 421 Score = 36.6 bits (83), Expect = 0.14 Identities = 50/236 (21%), Positives = 103/236 (43%), Gaps = 33/236 (13%) Query: 658 RQQHALRNRRLLRKVIKAAALEEHNAA----------MKDQLKLQEKDIQMWKVSLQKEQ 707 R QH+L+ + L + + A E A + +L+ +D + K L + + Sbjct: 161 RLQHSLQCKGELERALSAVIATEKKKANQLSSCSKAHTEWELEQSLQDQALLKAQLTQLK 220 Query: 708 ARYNQLQEQRD--------------TMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCR 753 + QLQ +RD ++K+ +I L+ ++++ + +EL+ L + Sbjct: 221 ESFQQLQLERDECAEHIEGERARWHQRMSKMLQEICTLKKEKQQDMRRVEELERSLSKLK 280 Query: 754 NMIAE-LRIELKKANNKV--CHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNEL 810 N +AE L E ++V H L +V+ +L + Q + LNR+ E Sbjct: 281 NQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQSQVKNNQHISLLNRRQEERIREQEE 340 Query: 811 YL----EQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELE 862 L E+LQ +H + +++ ++ + +EL LQ Q++ Q+++ E++ Sbjct: 341 RLRKQEERLQEQH-EKLRQLAKPQSVF-EELNNENKSTLQLEQQVKELQEKLGEVK 394 >gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] Length = 1417 Score = 58.2 bits (139), Expect = 4e-08 Identities = 63/280 (22%), Positives = 121/280 (43%), Gaps = 32/280 (11%) Query: 702 SLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRI 761 SL+ E + Q H+ +Q + +R+ +EL+TKL ++L++ Sbjct: 603 SLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKV 662 Query: 762 ELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSD 821 + ++ +L+ ++ +K SNS ++ +M QLL L + E E++ S Sbjct: 663 NMA---HRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLE---EKIVAYSSI 716 Query: 822 TTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLED 881 K E+ +EL + + ++T ++I L AKK H LEQ K +E Sbjct: 717 AAKNAEL-----EQELMEKNEKIRSLETNINTEHEKIC-LAFEKAKKIH--LEQHKEMEK 768 Query: 882 VKLQARGQLQAAESRYEAQKRITQVFELEI------LDLYGRL--EKDGLLKKLEEEKAE 933 + QL+ + +++ Q++ + + +I L+ RL E G +KK +K E Sbjct: 769 QIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDE 828 Query: 934 AAEAAE----------ERLDCCNDGCSDSMVGHNEEASGH 963 A +A + +LD + C + +V H + G+ Sbjct: 829 ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868 Score = 55.1 bits (131), Expect = 4e-07 Identities = 91/411 (22%), Positives = 165/411 (40%), Gaps = 53/411 (12%) Query: 578 KKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNK----LPLPSKSVDWTHFGGSPP 633 +K ++D + +E LDRL+ + KE K L V Sbjct: 788 EKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQL 847 Query: 634 SDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA-MKDQLKLQ 692 + +++L+L NQL + K ++ + + + K ++ H+ +Q + Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907 Query: 693 EKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLED- 751 + +Q + LQ+E R +L++ + TKL Q+ +L+ + ++ S E K+E+ Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQ----TKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963 Query: 752 CRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELY 811 C + E ++ +K + ++ Q +++++ L R GE ++ Sbjct: 964 CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD----GENKAMH 1019 Query: 812 LEQLQ----------NKHSDTTKEVEMMKAAYRKEL------------EKNRSH-----V 844 L QL K ++ KE+E ++ + EL E +H Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 1079 Query: 845 LQQTQRL-DTSQKRILELESHLAKKDHL---LLEQKKYLEDVKLQARGQLQAAESR-YEA 899 L+Q Q L D QK L LE L L E K +ED K + QA + R +E Sbjct: 1080 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL 1139 Query: 900 QKRITQVFELE--ILDLYGRLEK-----DGLLKKLEEEKAEAAEAAEERLD 943 ++R QV L+ I + G +E+ +G L+K E E E + E D Sbjct: 1140 KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 1190 Score = 52.8 bits (125), Expect = 2e-06 Identities = 63/283 (22%), Positives = 126/283 (44%), Gaps = 27/283 (9%) Query: 642 DQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQE--KDIQMW 699 DQ L N L +R + H R R ++ ++ K +L+L+E K I+ Sbjct: 1129 DQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESL 1188 Query: 700 KVSLQ--KEQARYNQ-LQEQRDTMVTKLHSQIRQLQHDREEFYN----QSQELQTKLEDC 752 LQ KEQ R + + Q + +++L +I + Q +E + Q Q + T+ ++ Sbjct: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEA 1248 Query: 753 RNMIAELRIELKKANNKVCHTELL------------LSQVSQKLSNSESVQQQMEFLNRQ 800 ++ ELR+ ++ N HTEL + ++S +L + + + ++ + Sbjct: 1249 IDLGQELRLTREQVQNS--HTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNH 1306 Query: 801 L---LVLGEVNELYLE-QLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQK 856 L L +V E +LE ++Q + + EVE +K AY E+ ++ + + D+ + Sbjct: 1307 LAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKS 1366 Query: 857 RILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEA 899 + +L L K L E + + ++ Q + + + E+ EA Sbjct: 1367 SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409 Score = 51.2 bits (121), Expect = 5e-06 Identities = 83/393 (21%), Positives = 164/393 (41%), Gaps = 67/393 (17%) Query: 588 GVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSD-EIRTLRDQL-- 644 G+ + SP E + ++ D K +K+ F S P D EI++LR++L Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKM-----------FSSSAPVDQEIKSLREKLNK 240 Query: 645 -------LLLHNQLLYERFKRQQHALRNRRLLRKVIKAAA--------LEEHNAAMKDQL 689 L+ N L +F+ L R ++++A LEE ++ ++ Sbjct: 241 LRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV 300 Query: 690 KLQEKDI--------QMWKVSLQKEQARYNQLQEQRDTMVTKLHS--QIRQLQHDREEFY 739 Q+K + Q K+ ++KEQ+ +E V L Q ++ + R E Sbjct: 301 SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL 360 Query: 740 NQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNR 799 ++EL + + +AE ++E +A ++ L + K +Q++ Sbjct: 361 YNAEELSKAFQQYKKKVAE-KLEKVQAEEEILERNLTNCEKENK-----RLQERCGLYKS 414 Query: 800 QLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRIL 859 +L +L E L QL+ ++++ +++ +M KN + Q T+ S++ IL Sbjct: 415 ELEILKEK----LRQLKEENNNGKEKLRIMAV-------KNSEVMAQLTE----SRQSIL 459 Query: 860 ELESHLAKKDHLLLEQKKYLED-----VKLQARGQ-LQAAESRYEAQKRITQVFELEILD 913 +LES L KD +L ++ + + V++ A+ + L + E+ + + E I Sbjct: 460 KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519 Query: 914 LYGRLEKDGLLKKLEEEKAEAAEAAEER-LDCC 945 L + E G L + + + E+R + CC Sbjct: 520 LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC 552 Score = 48.9 bits (115), Expect = 3e-05 Identities = 62/275 (22%), Positives = 122/275 (44%), Gaps = 25/275 (9%) Query: 678 LEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREE 737 LE+ A+K+ KLQ +LQK + +LQ +L S +RQLQ R+ Sbjct: 1034 LEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHG----ELKSTLRQLQELRDV 1089 Query: 738 FYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLS--NSESVQQQME 795 Q+ Q LE+ I +L EL++ ++ + L ++ Q L N E Q+ + Sbjct: 1090 L----QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145 Query: 796 FLNRQLLV---LGEVN------ELYLEQLQNKHSDTTKEVEMMKAAY---RKELEKNRSH 843 + + + GE+ E LE+ + + + K++E + +++L + Sbjct: 1146 VTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFI 1205 Query: 844 VLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQA--RGQLQAAESRYEAQK 901 +LQ Q + +K I + + + + ++ EQ++Y+ +A GQ + +R + Q Sbjct: 1206 MLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ-ELRLTREQVQN 1264 Query: 902 RITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAE 936 T++ E + + E + L +LE+ K + E Sbjct: 1265 SHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299 Score = 46.2 bits (108), Expect = 2e-04 Identities = 64/290 (22%), Positives = 123/290 (42%), Gaps = 51/290 (17%) Query: 653 YERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQ 712 YE+ +RQ+ L K+I+ +E N+ +K + + Q+ + L ++ + ++ Sbjct: 632 YEK-ERQRLVTGIEELRTKLIQ---IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687 Query: 713 LQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCH 772 L+ + +TK SQ+ L+ EE + K AEL EL + N K+ Sbjct: 688 LESE----MTKKCSQLLTLEKQLEEKIVAYSSIAAKN-------AELEQELMEKNEKIRS 736 Query: 773 TELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAA 832 E ++ +K+ L + +++LEQ H + K++E ++A Sbjct: 737 LETNINTEHEKIC----------------LAFEKAKKIHLEQ----HKEMEKQIERLEA- 775 Query: 833 YRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQA 892 +LEK +Q + + Q+ I+ + HL D LL E K ++ ++ L+A Sbjct: 776 ---QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA 832 Query: 893 AESRYEAQ----KRITQVFE-------LEILDLYGRLEK-DGLLKKLEEE 930 +++ + +++ E L + L G EK + LKK EE Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEE 882 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.129 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,047,432 Number of Sequences: 37866 Number of extensions: 2651291 Number of successful extensions: 18289 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 211 Number of HSP's successfully gapped in prelim test: 1079 Number of HSP's that attempted gapping in prelim test: 13079 Number of HSP's gapped (non-prelim): 4845 length of query: 1113 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1000 effective length of database: 13,968,660 effective search space: 13968660000 effective search space used: 13968660000 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.