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Search of human proteins with 239755187
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
(1215 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 2467 0.0
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 1964 0.0
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 1331 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 946 0.0
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 324 4e-88
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 324 4e-88
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 267 5e-71
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 245 2e-64
gi|139948432 adlican [Homo sapiens] 245 2e-64
gi|110349719 titin isoform N2-A [Homo sapiens] 228 3e-59
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 216 1e-55
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 211 3e-54
gi|109150416 peroxidasin [Homo sapiens] 195 3e-49
gi|4506569 roundabout 1 isoform a [Homo sapiens] 188 3e-47
gi|19743806 roundabout 1 isoform b [Homo sapiens] 186 2e-46
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 185 3e-46
gi|224994173 roundabout 1 isoform d [Homo sapiens] 182 1e-45
gi|224994171 roundabout 1 isoform c [Homo sapiens] 182 1e-45
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 182 1e-45
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 182 1e-45
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 181 4e-45
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 181 4e-45
gi|222352127 sidekick 2 [Homo sapiens] 179 2e-44
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 174 4e-43
gi|126517478 peroxidasin homolog-like [Homo sapiens] 174 4e-43
gi|119220552 sidekick 1 [Homo sapiens] 167 6e-41
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 163 8e-40
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 160 7e-39
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 160 7e-39
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 155 2e-37
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 2467 bits (6393), Expect = 0.0
Identities = 1215/1215 (100%), Positives = 1215/1215 (100%)
Query: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH
Sbjct: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
Query: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF
Sbjct: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
Query: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK
Sbjct: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
Query: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD
Sbjct: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
Query: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG
Sbjct: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
Query: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG
Sbjct: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
Query: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR
Sbjct: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD
Sbjct: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
Query: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL
Sbjct: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
Query: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 660
VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE
Sbjct: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 660
Query: 661 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 720
IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS
Sbjct: 661 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 720
Query: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL
Sbjct: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840
EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA
Sbjct: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840
Query: 841 TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT 900
TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT
Sbjct: 841 TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT 900
Query: 901 SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA
Sbjct: 901 SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
Query: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG 1020
NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG
Sbjct: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG 1020
Query: 1021 DSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVR 1080
DSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVR
Sbjct: 1021 DSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVR 1080
Query: 1081 LCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPLRGPGDAVQRPPTTQGRAQWG 1140
LCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPLRGPGDAVQRPPTTQGRAQWG
Sbjct: 1081 LCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPLRGPGDAVQRPPTTQGRAQWG 1140
Query: 1141 PGFGRTGVRGEPMKVGLRGSLPGTRGPAGSPGCGDGKRPVRCHRAPPAGSILMPPRGPSE 1200
PGFGRTGVRGEPMKVGLRGSLPGTRGPAGSPGCGDGKRPVRCHRAPPAGSILMPPRGPSE
Sbjct: 1141 PGFGRTGVRGEPMKVGLRGSLPGTRGPAGSPGCGDGKRPVRCHRAPPAGSILMPPRGPSE 1200
Query: 1201 PLLPPLPSTRHFVHL 1215
PLLPPLPSTRHFVHL
Sbjct: 1201 PLLPPLPSTRHFVHL 1215
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 1964 bits (5089), Expect = 0.0
Identities = 993/1052 (94%), Positives = 995/1052 (94%), Gaps = 45/1052 (4%)
Query: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGD TH
Sbjct: 118 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTH 177
Query: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF
Sbjct: 178 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 237
Query: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK
Sbjct: 238 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 297
Query: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD
Sbjct: 298 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 357
Query: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG
Sbjct: 358 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 417
Query: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG
Sbjct: 418 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 477
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 537
Query: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR
Sbjct: 538 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 597
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD
Sbjct: 598 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 657
Query: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL
Sbjct: 658 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 717
Query: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 660
VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE
Sbjct: 718 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 777
Query: 661 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 720
IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS
Sbjct: 778 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 837
Query: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL
Sbjct: 838 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 897
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840
EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA
Sbjct: 898 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 957
Query: 841 TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT 900
TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT
Sbjct: 958 TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT 1017
Query: 901 SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN
Sbjct: 1018 SRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNR------------ 1065
Query: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG 1020
L ++ EE YGLLPSGSLRLAQVQVG
Sbjct: 1066 ---LALSKYVWEE------------------------------YGLLPSGSLRLAQVQVG 1092
Query: 1021 DSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
DSGHYECTASNPAGSASHRYVLGVQ QP
Sbjct: 1093 DSGHYECTASNPAGSASHRYVLGVQVPPQVQP 1124
Score = 324 bits (830), Expect = 4e-88
Identities = 236/724 (32%), Positives = 331/724 (45%), Gaps = 49/724 (6%)
Query: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 3435 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 3490
Query: 397 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 454
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 3491 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 3543
Query: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 511
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 3544 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 3602
Query: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 570
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 3603 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 3662
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI-------L 623
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 3663 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 3722
Query: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
PEGS LRI +DAG Y C A N G L V P + P ++T+
Sbjct: 3723 LPEGS----LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
ALL C A+G P P V W + DGQ L RL G R S L + P+D A +
Sbjct: 3779 TPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGA---YRLLPSNALLLTAPGPQDSAQF 3834
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
C N G +A VT H PP IA V PV L C G P P W
Sbjct: 3835 ECVVSNEVG--EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWS 3891
Query: 804 KDGRPLPP-GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH 862
K G L GS + + G+L + +AL HAGRY+C A N+AG H+ V L VQ P +
Sbjct: 3892 KAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVK 3951
Query: 863 P--TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
P + + E V LPC ASG+P PTITW KE + G V G L IA S
Sbjct: 3952 PLPSVVRAVAEEEV--LLPCEASGIPRPTITWQKE-GLNVATGVSTQVLPGGQLRIAHAS 4008
Query: 921 AQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
+DAG Y+C A N+ G + + RL V P I NG + ++ G L C+A
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD------LSTTEGSHAFLPCKA 4061
Query: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1040
+GSP P +TW KD +PV ++ + PSG L + ++ D+G Y CTA N G A R
Sbjct: 4062 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRV 4121
Query: 1041 VLGV 1044
L +
Sbjct: 4122 HLTI 4125
Score = 315 bits (806), Expect = 2e-85
Identities = 218/687 (31%), Positives = 316/687 (45%), Gaps = 32/687 (4%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTV--SPG 414
E+ + + +LR A G Y C A S AG ++ V PP + P P V +PG
Sbjct: 3540 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 3597
Query: 415 ETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
+ VL C V E +TW RD VL L++ + D G Y C A N
Sbjct: 3598 QL-VLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 3656
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
A G T + + + P + + + S + C A G P P +SW ++ L
Sbjct: 3657 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 3716
Query: 535 S-RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
S R + +G+L IQ V +DAG+Y C A+N G+D++ L +PP+++ + + +
Sbjct: 3717 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLT 3776
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTC 648
A+L CEASG P P V+W++ G ++ + + S L + A +D+ + C
Sbjct: 3777 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 3836
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
NE+G+A Q+ V P + + D TV + +L C +TG P PTV+W +
Sbjct: 3837 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA--- 3893
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
G +LGA RGS R SG L P Y C ARN G A + +T A P
Sbjct: 3894 --GAQLGA-RGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV--AHKHVFLTVQASP 3948
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA 828
+ VR + + V LPC +G P P W K+G + G + G L + A
Sbjct: 3949 VVKPLPSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHA 4007
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
E AG Y C+A N+AGS LVVQVPP I T EG A LPC A G P P
Sbjct: 4008 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP 4067
Query: 889 TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT 948
ITW K+ ++ + + G LL+ QDAG Y CTA N VG + + + L++
Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 4127
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP-ITNRYGLL 1007
P +P + + G+ + L C A+GSP P + WT + RPV ++ + G
Sbjct: 4128 LPVF-------TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-- 4178
Query: 1008 PSGSLRLAQVQVGDSGHYECTASNPAG 1034
+L+ A V DSG Y C A N G
Sbjct: 4179 -GSTLQRAAVSREDSGTYVCWAENRVG 4204
Score = 287 bits (735), Expect = 4e-77
Identities = 225/785 (28%), Positives = 343/785 (43%), Gaps = 38/785 (4%)
Query: 317 PRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEER-HFQESGNSSWEILRASKAEEG 375
P ++ ++Q L+ C + R+ L F+ S I + G
Sbjct: 3680 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 3739
Query: 376 TYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWV 434
Y C A + AG+ R + V +PP + P+P N+T++ A+L C G + W
Sbjct: 3740 HYLCLASNSAGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 3798
Query: 435 RDWRVLP--ASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 492
+D + L G L +L ++ P D +++CV SN G + V P
Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858
Query: 493 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL-QEDSRIHVDAQGTLIIQGVA 551
++ + + V ++C ++G P P +SWS+ L S V G L I
Sbjct: 3859 IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQAL 3918
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 611
P AG Y+C A N G + V L P V + +VV EE +L CEASG+P P
Sbjct: 3919 PIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT 3978
Query: 612 VIWYRGGLEMI--LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
+ W + GL + ++ + G+LRI A DAG Y C A N G A + +L V P
Sbjct: 3979 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP 4038
Query: 670 QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 729
+ D++ G A L C+A G P P +TW + DGQP+ G + QP SG
Sbjct: 4039 VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVS----GAEGKFTIQP-SGE 4092
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLP 788
L +++ +D Y C A N G+ + L + + ++ P R L G + L
Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL---VLPVFTTLPGDRSLRLGDRLWLR 4149
Query: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL--QEHAGRYSCVATNTAGS 846
C G P P W + RP+ G DG L RA +E +G Y C A N G
Sbjct: 4150 CAA-RGSPTPRIGWTVNDRPVTEGVSEQ---DGGSTLQRAAVSREDSGTYVCWAENRVGR 4205
Query: 847 QHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ V+ P + A ++ G L CV G P P I W K+ L RG H
Sbjct: 4206 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD--GLPLRGSH 4263
Query: 906 YNVS-KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ G+L I + DAG Y C A N +G + + + L + + P + P
Sbjct: 4264 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE-------PQ 4316
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
+T ++G++V L C+A G P P + W + +P+ + R LP GSL L V+ GD+G
Sbjct: 4317 DMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGT 4375
Query: 1025 YECTASNPAGSASHRYVLGVQG--RTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLC 1082
Y+C A N GSA+ R L V+G + SW + + ++ L+ ++Q V
Sbjct: 4376 YDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSI 4435
Query: 1083 HLSLR 1087
H S+R
Sbjct: 4436 HSSIR 4440
Score = 285 bits (729), Expect = 2e-76
Identities = 226/698 (32%), Positives = 312/698 (44%), Gaps = 52/698 (7%)
Query: 360 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAV 418
G EI A +++G Y C + AG + V PP P V+ G V
Sbjct: 3084 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV 3143
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
L+C V G +TW++D + +S L++S + P G Y CVA N
Sbjct: 3144 LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 3203
Query: 479 TRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS- 535
R + V AP++ S H +G EV++ C A G P P ++W ++ L +D
Sbjct: 3204 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 3263
Query: 536 ---RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS--AVNAVV 590
R ++D G+L+++G+ DAG Y+C A N G D T+ PP++ A +
Sbjct: 3264 PHLRFYLDG-GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 3322
Query: 591 LVA-VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTY 646
LV+ GE +VC G PP V W + GL + L+ G LRI Q DAG +
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 3382
Query: 647 TCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
TC A + G A L V P L E DV V G L C A G P P V+W +
Sbjct: 3383 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK 3442
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSGV-LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG+PL S+ + G L E+V D Y C A + G+ + +L V
Sbjct: 3443 -DGEPL----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 3491
Query: 764 GHAPPQIASSA-PT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP I S PT + + G P+ L C G P P W KDG+ L R +
Sbjct: 3492 --EPPHIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALT-------RLEN 3541
Query: 822 SLHLDRALQ-EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL-- 878
+ R L+ AG Y+C+A + AG+ + + VQ PP I P L
Sbjct: 3542 NSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 3601
Query: 879 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQP-SAQDAGAYVCTATNTVGF 937
C PAP ITW ++ L H + G L Q S D+G Y CTA N G
Sbjct: 3602 ECSVEAEPAPKITWHRDGIVL-QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 3660
Query: 938 SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
+S R+ ++T P I +G NV + TA L C+A G P PLV+W KD P+
Sbjct: 3661 TSVAFRVEIHTVPTIR-SGPPAVNVSVNQTA------LLPCQADGVPAPLVSWRKDRVPL 3713
Query: 998 PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
P + R+ +LP GSLR+ V D+GHY C ASN AGS
Sbjct: 3714 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 3751
Score = 283 bits (725), Expect = 5e-76
Identities = 224/766 (29%), Positives = 335/766 (43%), Gaps = 46/766 (6%)
Query: 306 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 360
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 417
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 3274 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331
Query: 418 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 477
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 3391
Query: 478 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 3392 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 3450
Query: 535 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 592
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 3451 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 3507
Query: 593 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 3508 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 3563
Query: 653 ELGDASAEIQLAVGHAPQLT--ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 710
G ++ V P + PR V +L C P P +TW R DG L
Sbjct: 3564 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVL 3622
Query: 711 GLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
+ ++ P+ G L ++++ D Y C ARN G R+ + H P
Sbjct: 3623 Q------EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI--HTVPT 3674
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRA 828
I S P V V Q LPC G P P W KD PL P S R I +GSL +
Sbjct: 3675 IRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPV 3733
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
L + AG Y C+A+N+AGS + +L V PP I P+ ++ PA LPC ASG P P
Sbjct: 3734 LAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 3793
Query: 889 TITWTKETNALTSRGPH--YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+ W K+ L R Y + LL+ P QD+ + C +N VG + + +++V
Sbjct: 3794 LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 3853
Query: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
+ P I A+ T V L C + G P P V+W+K + + Y +
Sbjct: 3854 HVPPTI-------ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 3906
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
PSG+L + Q +G Y C+A N AG A L VQ +P
Sbjct: 3907 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKP 3952
Score = 276 bits (706), Expect = 9e-74
Identities = 231/778 (29%), Positives = 331/778 (42%), Gaps = 69/778 (8%)
Query: 311 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 365
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 2036
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 425
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 2037 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 2096
Query: 426 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 2097 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 2156
Query: 486 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 542
V AP + S + +G +SC G P P ISW ++ Q L + HV A
Sbjct: 2157 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 2216
Query: 543 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 598
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 2276
Query: 599 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 2277 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 2333
Query: 653 ELGDASAEIQLAVGHAPQLT---ELPRDVTVELGRSALLACRATGRPPPTVTWRRGD--- 706
G A + +L+V P+L + ++T L L C A G PPP + W RG+
Sbjct: 2334 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV 2393
Query: 707 --GQPLGLRLGAG--RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
G+ L G + +++++ DSG+ Y C A N G +A V
Sbjct: 2394 SPGEDTYLLAGGWMLKMTQTQEQDSGL-------------YSCLASNEAG--EARRNFSV 2438
Query: 763 TGHAPPQIASS--APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
PP I + ++VL+GQ L C V G P P+ W KDGRPL G H I D
Sbjct: 2439 EVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKLTWFKDGRPLARGDAHHISPD 2497
Query: 821 GSL-HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHIT-NEGV 874
G L + +A AG YSC+A N G + + +L V + P I +A +T
Sbjct: 2498 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 2557
Query: 875 PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-------IAQPSAQDAGAY 927
P SL C A P+P ITW K+ G + S+ LL I +DAG Y
Sbjct: 2558 PISLICEALAFPSPNITWMKD-------GAPFEASRNIQLLPGTHGLQILNAQKEDAGQY 2610
Query: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
C TN +G + + + V P I + +V K +TL+CE+ PPP
Sbjct: 2611 TCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT 2670
Query: 988 VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ W KD +PV P + L L++ QV DSG Y C A+N AG + + +Q
Sbjct: 2671 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 2728
Score = 270 bits (691), Expect = 5e-72
Identities = 238/771 (30%), Positives = 334/771 (43%), Gaps = 94/771 (12%)
Query: 310 APLVSMAPR-IHGYLHQPLLVSCSVHSALPFRLQLRRGEA-----RLGEERHFQESGNSS 363
AP ++ PR + L + L++C P + RRG+ RLG R + S
Sbjct: 785 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 844
Query: 364 WEILRASKAEE--GTYECTAVSRAGTGRAKAQIVVTD-PPPQLVP-APNVTVSPGETAVL 419
+ S A E Y C A + G +A+A+++VT PPQ+ AP V V G+ L
Sbjct: 845 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 904
Query: 420 SCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
C VL P W++D R LP + R + AD SL + + GRY CVA+N G
Sbjct: 905 PCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963
Query: 479 TRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQAL-QEDS 535
V L+V+ P+ IH ++ H ++GV + C ASG P P I+W++E+ AL
Sbjct: 964 QHRDVELVVQVPPR--IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 1021
Query: 536 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVG 595
+V +GTL+I + +DAG Y C ATN VG + + L +VN + L
Sbjct: 1022 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL---------SVNRLAL---- 1068
Query: 596 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
+ +W GL SG LR+ Q D+G Y C A N G
Sbjct: 1069 --------------SKYVWEEYGL--------LPSGSLRLAQVQVGDSGHYECTASNPAG 1106
Query: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLG 715
AS L V PQ+ PR + V +G + L C A G P P ++W + DG L
Sbjct: 1107 SASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVL----- 1160
Query: 716 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS--S 773
GRG + G + F ++ D Y CEA N G E L V PP + +
Sbjct: 1161 QGRGPQ------GSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVL--EPPHWGADET 1212
Query: 774 APTVRVLEGQPVSLPCIVLAGRPLPERHWLK--DGRPLPPGSRHSIRADGSLHLDRALQE 831
+ + + G+ SLPC G P P+ W K PL ++ +GSL L
Sbjct: 1213 SGLLERVAGENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPA 1271
Query: 832 HAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN--EGVPASLPCVASGVPAPT 889
+G Y C ATN GS R +LVV VPP I + G +L C A+G P P
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331
Query: 890 ITWTKETNAL---------------TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 934
I W K+ + G H + + +L + D+G Y C A N
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQ 1391
Query: 935 VGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDS 994
G + ++ L V T P + A +V AG +V L C G P P V WTKD
Sbjct: 1392 AGTAQRDFHLLVLTPPSV-----LGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 1446
Query: 995 RPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
+PV P + G LR+ VGD G Y+C A +PAG + + L V
Sbjct: 1447 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Score = 269 bits (688), Expect = 1e-71
Identities = 249/863 (28%), Positives = 360/863 (41%), Gaps = 90/863 (10%)
Query: 351 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 407
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 1453 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 1506
Query: 408 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 460
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 1507 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 1563
Query: 461 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE---VKVSCSASGY 517
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 1623
Query: 518 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 1624 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683
Query: 577 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGK 632
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 1743
Query: 633 -LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH--APQLTELPRDVTVELGRSALLA 689
L I + +G + C+A NE G A AE++++V AP + E+P G +
Sbjct: 1744 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIG-QYHWGXEHHSS 1802
Query: 690 CRATGRPPPTVTWRRGDGQPL-------GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
A PP W PL G G G L E V D+
Sbjct: 1803 FPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGI 1862
Query: 743 YVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
Y C A N+ G+ + E L V PP I VLE V+L C+ +G P P+ W
Sbjct: 1863 YTCAATNLAGESKREVALKVL--VPPNIEPGPVNKAVLENASVTLECLA-SGVPPPDVSW 1919
Query: 803 LKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861
K +P+ ++ DG L +++A AG Y CVA+N AGS L V VPPRI
Sbjct: 1920 FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRI 1979
Query: 862 H-PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG-PHYNVSKEGTLL-IAQ 918
P + P L C A+G P+PT+ W K+ N ++ G P V G +L +A
Sbjct: 1980 TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLAS 2039
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC 978
A D+G Y C A + VG Q++ L V+ P I L V+ A E V L+C
Sbjct: 2040 ARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI-------LGEELNVSVVANESVALEC 2092
Query: 979 EAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1038
++ PPP+++W KD RP+ P + L++ + V D+GHY C A N AG +
Sbjct: 2093 QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK 2152
Query: 1039 RYVLGVQGRTSWQPQSLPVPH---------HPACLS----GLSVPLL------QPTP-RS 1078
Y L V W P+ HP LS G+ P + QP P
Sbjct: 2153 HYNLNV-----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207
Query: 1079 VRLCHLSL--------RAPLPPPFATPTSCLSQACLSSSTLSLHLS-PYPLRGPGDAVQR 1129
L H+S +A L C + SS L L + P + GP +
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP----RE 2263
Query: 1130 PPTTQGRAQWGPGFGRTGVRGEP 1152
PPT Q G G+P
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKP 2286
Score = 268 bits (686), Expect = 2e-71
Identities = 234/784 (29%), Positives = 326/784 (41%), Gaps = 89/784 (11%)
Query: 323 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 378
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 2366 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 2422
Query: 379 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 434
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 2480
Query: 435 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 494
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 2481 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 2539
Query: 495 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 546
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 2540 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 2598
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGE------- 596
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V E
Sbjct: 2599 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655
Query: 597 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 653
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 2656 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 2715
Query: 654 LGDASAEIQLAVGHAPQLTE----------LPRDVTVELG----------RSALLACRAT 693
G+ + + + P + L R+ G A L C
Sbjct: 2716 AGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN 2775
Query: 694 GRPPPTVTWRRGDGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
PPP +TW R D QPL G + +G R VL V E+ Y C+A N
Sbjct: 2776 AIPPPDLTWYRED-QPLSAGDEVSVLQGGR-------VLQIPLVRAENAGRYSCKASNEV 2827
Query: 752 GKVQAEARLIVTGHAPPQIASSAPT----VRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
G+ L+V PP I V V VSL C L G P+P WL++G
Sbjct: 2828 GEDWLHYELLVL--TPPVILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTISWLQNGL 2884
Query: 808 PLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTAT 866
P P R + DG L + A A Y CVA N AGS + L VQVPPRI
Sbjct: 2885 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 2944
Query: 867 HHIT---NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 923
+T N V SLPC P P +TW K++ AL+ + + TL + + D
Sbjct: 2945 EQVTAILNSSV--SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSD 3002
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHM--NGSRNANVPLQVTAKAGEEVTLDCEAK 981
+G Y C A N G + ++LSV P G ++A V + G++ L CE
Sbjct: 3003 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDA-----VLVRVGDKAVLSCETD 3057
Query: 982 GSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
P P VTW KD +P+ L L + + QV D G Y C SN AG A +
Sbjct: 3058 ALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 3117
Query: 1042 LGVQ 1045
L VQ
Sbjct: 3118 LTVQ 3121
Score = 257 bits (657), Expect = 4e-68
Identities = 201/700 (28%), Positives = 309/700 (44%), Gaps = 45/700 (6%)
Query: 375 GTYECTAVSRAGTGRAKAQIVVTDP-PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTW 433
G + C A + AGT A+ ++ V P ++ P G S + P + W
Sbjct: 1756 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 1815
Query: 434 --------VRDWRVLPASTGR-----VAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
V W + G VA L+I + D G Y C A+N G ++
Sbjct: 1816 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 1875
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
V L V P + ++ + V + C ASG P P +SW + Q + + V
Sbjct: 1876 REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVS 1935
Query: 541 AQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV-LVAVGEEA 598
G ++ I+ DAG+Y C A+N G+ + L PP ++ ++ V V
Sbjct: 1936 VDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPV 1995
Query: 599 VLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-------LRIPAAQERDAGTYTCRAV 651
L C A+G P P ++W + G + +P G+ + L + +A+ D+G Y+C AV
Sbjct: 1996 RLTCNATGAPSPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 2053
Query: 652 NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG 711
+ +G+ ++ L V P + +V+V S L C++ PPP ++W + DG+PL
Sbjct: 2054 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLE 2112
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
R G + D +L + D Y CEA N G + L V AP
Sbjct: 2113 PRPGVHLSA-----DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV-APVFPL 2166
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP---PGSRHSIRADGSLHLDRA 828
+ T+ V EG P SL C G P P+ W KDG+PLP G +H L+L +A
Sbjct: 2167 RESHTLTVREGHPTSLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 2225
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHITNEGVPASLPCVASG 884
G Y+C +N G+ +D++L V VPP+I P + +GV A+L C A+G
Sbjct: 2226 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATG 2284
Query: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
P PT+TW ++ + + ++ +L + + A G Y C A N G + ++ L
Sbjct: 2285 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 2344
Query: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY 1004
SV P + + N+ TA +TL CEA G PPP + W + PV P + Y
Sbjct: 2345 SVLVPPELIGDLDPLTNI----TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 2400
Query: 1005 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
L L++ Q Q DSG Y C ASN AG A + + V
Sbjct: 2401 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 2440
Score = 250 bits (638), Expect = 7e-66
Identities = 216/732 (29%), Positives = 303/732 (41%), Gaps = 52/732 (7%)
Query: 346 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 405
G ++G R E S R + + G Y C A ++AGT + ++V PP L
Sbjct: 1355 GWGQVGGHRLLDEG--QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412
Query: 406 --APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIP 462
A V G L C G + W +D + VLP Q L I+G
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 1472
Query: 463 TDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTP 520
D GRYQCVA + G L V P + S T + V++ C A G PTP
Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 1532
Query: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNEVGTDQETVTLYYTD 579
+I+W ++ L +++ G + G A DAG Y+C+A+N VG ++ L
Sbjct: 1533 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592
Query: 580 PPSVSAVNA---VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKL 633
PP++ VV G L C A G P P + W+ GL + + E + L
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 1652
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACR 691
R+ + E +G Y+C A + G+A + + V PQL E VT +G+ L C+
Sbjct: 1653 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQ 1712
Query: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
A+G P PT+ W + +G+P G S+ L + V + + C+A N
Sbjct: 1713 ASGSPVPTIQWLQ-NGRPAEELAGVQVASQGT-----TLHIDHVELDHSGLFACQATNEA 1766
Query: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEG--QPVSLPCIVLAGRPLPERHWLKDGRP- 808
G AE + V G P + P + G S P A P R W +P
Sbjct: 1767 GTAGAEVEVSVHGEWAPGVL-EVPIGQYHWGXEHHSSFPA---ACDPPVHRGWGAHPKPP 1822
Query: 809 -------------LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV 855
P G + L +++ G Y+C ATN AG R+V L V
Sbjct: 1823 LVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 1882
Query: 856 QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL 915
VPP I P + E +L C+ASGVP P ++W K ++S VS +G +L
Sbjct: 1883 LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS-WMGVTVSVDGRVL 1941
Query: 916 -IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
I Q DAG+Y C A+N G + L VN PRI + S L V
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPS------LPGPVLVNTPV 1995
Query: 975 TLDCEAKGSPPPLVTWTKDSRPVPPI-TNRYGLLPSGS-LRLAQVQVGDSGHYECTASNP 1032
L C A G+P P + W KD PV P T + P G L LA + DSG Y C A +
Sbjct: 1996 RLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 2055
Query: 1033 AGSASHRYVLGV 1044
G VL V
Sbjct: 2056 VGEDRQDVVLQV 2067
Score = 244 bits (622), Expect = 5e-64
Identities = 213/756 (28%), Positives = 306/756 (40%), Gaps = 62/756 (8%)
Query: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 408
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 2489 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 2547
Query: 409 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
VTV+ L C L N+TW++D AS L+I D
Sbjct: 2548 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 2607
Query: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS-QGVEVKVS------CSASGYP 518
G+Y CV +N G + + V P +S + V+ KV+ C + P
Sbjct: 2608 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 2667
Query: 519 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 2668 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727
Query: 578 TDPPSVSAVN----AVVLVAVGEEA----------------VLVCEASGVPPPRVIWYRG 617
PP V A +++ EEA L C+ + +PPP + WYR
Sbjct: 2728 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 2787
Query: 618 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT-- 672
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V P +
Sbjct: 2788 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGD 2847
Query: 673 --ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
EL +VTV + L C A G P PT++W + GL + + D VL
Sbjct: 2848 TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN-----GLPFSPSPRLQVLE-DGQVL 2901
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS-SAPTVRVLEGQPVSLPC 789
+ D A Y+C A N G AE + PP+IA V + VSLPC
Sbjct: 2902 QVSTAEVADAASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 2959
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V A P PE W KD + L G + +L L RA +G Y+C A N AG
Sbjct: 2960 DVHA-HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQ 3018
Query: 849 RDVELVVQVPP--RIHPTATHH--ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
+ V+L V VPP R P + G A L C +P PT+TW K+ L
Sbjct: 3019 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 3078
Query: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ L I + D G Y C +N G + + L+V P +
Sbjct: 3079 TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----- 3133
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
V+ AG + L C+ G P P VTW KD PV + G L+L+++Q +G
Sbjct: 3134 -VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 3192
Query: 1025 YECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHH 1060
Y C A N A +V+ V + + HH
Sbjct: 3193 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 3228
Score = 237 bits (605), Expect = 4e-62
Identities = 224/758 (29%), Positives = 310/758 (40%), Gaps = 61/758 (8%)
Query: 313 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 363
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 2933 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 2992
Query: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 419
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 3052
Query: 420 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 3053 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 3112
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 537
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 3113 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 3170
Query: 538 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 593
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 3171 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 3230
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 648
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 3231 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL----GRSALLACRATGRPPPTVTWRR 704
A N G+ A + P + D + L G + C G PP V+W +
Sbjct: 3291 VAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK 3349
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG PL L R+ SG L V D + C A + G A+ +
Sbjct: 3350 -DGLPLPL------SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ 3400
Query: 764 GHAPPQI--ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP + V V+ G V LPC G PLP W+KDG PL S+
Sbjct: 3401 VQVPPVLEPVEFQNDVVVVRGSLVELPC-EARGVPLPLVSWMKDGEPL---LSQSLEQGP 3456
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA--THHITNEGVPASLP 879
SL L+ +G YSCVA + AG R +L V PP I + T G P L
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELL 3516
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
C A G P P ITW K+ ALT N S+ +L +DAG Y C A + G
Sbjct: 3517 CDAQGTPQPNITWHKDGQALTRL---ENNSRATRVL----RVRDAGLYTCLAESPAGAIE 3569
Query: 940 QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
+ R+ V P I G R P V A ++ L+C + P P +TW +D +
Sbjct: 3570 KSFRVRVQAPPNI--VGPRG---PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQE 3624
Query: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
+ L+L + DSG Y CTA N AGS S
Sbjct: 3625 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 3662
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 1331 bits (3445), Expect = 0.0
Identities = 665/666 (99%), Positives = 665/666 (99%)
Query: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGD TH
Sbjct: 117 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTH 176
Query: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF
Sbjct: 177 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 236
Query: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK
Sbjct: 237 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 296
Query: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD
Sbjct: 297 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 356
Query: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG
Sbjct: 357 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 416
Query: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG
Sbjct: 417 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 476
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS
Sbjct: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
Query: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR
Sbjct: 537 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD
Sbjct: 597 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 656
Query: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL
Sbjct: 657 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
Query: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 660
VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE
Sbjct: 717 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 776
Query: 661 IQLAVG 666
IQLAVG
Sbjct: 777 IQLAVG 782
Score = 155 bits (393), Expect = 2e-37
Identities = 131/388 (33%), Positives = 181/388 (46%), Gaps = 28/388 (7%)
Query: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727
AP ++ PR + L + L++C P + RRG+ RLG R + S
Sbjct: 426 APLVSMAPR-IHGYLHQPLLVSCSVHSALPFRLQLRRGEA-----RLGEERHFQESGNSS 479
Query: 728 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
+ S A E Y C A + G +A+A+++VT PPQ+ AP V V G+ L
Sbjct: 480 WEILRASKAEE--GTYECTAVSRAGTGRAKAQIVVTD-PPPQLVP-APNVTVSPGETAVL 535
Query: 788 PCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846
C VL P W++D R LP + R + AD SL + + GRY CVA+N G
Sbjct: 536 SCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 594
Query: 847 QHRDVELVVQVPPR--IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
V L+V+ P+ IH ++ H ++GV + C ASG P P I+W++E+ AL
Sbjct: 595 TRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQAL-QEDS 651
Query: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+V +GTL+I + +DAG Y C ATN VG + + L P + + V
Sbjct: 652 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-------SAVNA 704
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
V GEE L CEA G PPP V W + + I G SG LR+ Q D+G
Sbjct: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEG-SSSGKLRIPAAQERDAGT 761
Query: 1025 YECTASNPAGSASHRYVLGVQGRTSWQP 1052
Y C A N G AS L V GR P
Sbjct: 762 YTCRAVNELGDASAEIQLAV-GRGGGYP 788
Score = 139 bits (351), Expect = 1e-32
Identities = 113/352 (32%), Positives = 153/352 (43%), Gaps = 24/352 (6%)
Query: 602 CEASGVPPPRVIWYRG----GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 657
C P R+ RG G E G+SS + I A + + GTY C AV+ G
Sbjct: 447 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWE--ILRASKAEEGTYECTAVSRAGTG 504
Query: 658 SAEIQLAVGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 716
A+ Q+ V P QL P +VTV G +A+L+CR G P +TW R D + L G
Sbjct: 505 RAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPASTG- 561
Query: 717 GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT 776
R Q L + P D Y C A N G +A L+V PQ++ +
Sbjct: 562 ----RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSS 615
Query: 777 VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 836
+G V + C +G P P W ++ + L SR + A G+L + E AG Y
Sbjct: 616 QHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 674
Query: 837 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE- 895
SC ATN G+ V L PP + + G A L C ASGVP P + W +
Sbjct: 675 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
Query: 896 -TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
L G S G L I +DAG Y C A N +G +S E++L+V
Sbjct: 735 LEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
Score = 69.3 bits (168), Expect = 2e-11
Identities = 74/295 (25%), Positives = 105/295 (35%), Gaps = 47/295 (15%)
Query: 788 PCIVLAGRPLPE--RHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAG-RYSCVATNT 843
P + L +PL H L G P P R ++ G H L +G YS VA
Sbjct: 367 PLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGA 426
Query: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
+V + PRIH P + C P + A
Sbjct: 427 P---------LVSMAPRIHGYLHQ-------PLLVSCSVHSA-LPFRLQLRRGEARLGEE 469
Query: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963
H+ S + I + S + G Y CTA + G + ++ V T P + + N
Sbjct: 470 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV-TDPPPQLVPAPN---- 524
Query: 964 LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSG 1023
VT GE L C G P +TW +D R +P T R L SL ++ + D G
Sbjct: 525 --VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 582
Query: 1024 HYECTASNPAG-------------------SASHRYVLGVQGRTSWQPQSLPVPH 1059
Y+C ASN G ++S + GV+ + S P PH
Sbjct: 583 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH 637
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 946 bits (2444), Expect = 0.0
Identities = 477/1052 (45%), Positives = 678/1052 (64%), Gaps = 13/1052 (1%)
Query: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
MS+GAIK A+E++ PGSFIYVF+DAR+KDY E+L+L+Q KQSQVVFVLTGDC D TH
Sbjct: 121 MSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHEVLQLIQQKQSQVVFVLTGDCDDRTH 180
Query: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
GY YEEIA+TSSGQVFHLDK+QV EVLKWVE A+QASKVHLLSTDH E+ +TWR+PF
Sbjct: 181 IGYKVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQASKVHLLSTDHLEQAVNTWRIPF 240
Query: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
DPSLKEVT+SLSGP P IE+++PLG+++++ GL+ LLNI +SAKVV K G+W++K
Sbjct: 241 DPSLKEVTVSLSGPSPMIEIRNPLGKLIKKGFGLHELLNIHNSAKVVNVKEPEAGMWTVK 300
Query: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
SSGRHSVRITG+S IDFRAGFS +P LD T+ P+QG+P +++N++G+ P R+D
Sbjct: 301 TSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSRPVQGIPTYVLLNTSGISTPARID 360
Query: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
+EL SG L T+P K + + +W F P E F+LKV G D + RVS
Sbjct: 361 LLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPPNEAFFLKVTGYDKDDYLFQRVSS 420
Query: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
VS+S + P AP V+M + GY QP + CSV S LPF L R LG +++ +ES
Sbjct: 421 VSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESA 480
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
+ + +I + + ++EG YEC AVS AGTGRA+ V++PPP + NVTV+PGE AVL+
Sbjct: 481 SVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLT 540
Query: 421 CRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
C ++ YNLTW R+ R V A R+ LA+LSLE+ + D G Y C+ S+ G +
Sbjct: 541 CLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSS 600
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
ASV+L V+E P+V++ +Q F+ G EV + CSA+GYP P I+W+ + R +
Sbjct: 601 AASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRM 660
Query: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
+ GTL I+ AP+DAG Y C A+N GTD++ TL Y + P + V + +LVA+G+ V
Sbjct: 661 TSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITV 720
Query: 600 LVCEASGVPPPRVIWYRGGLE------MILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 653
+ C+ SG+PPP+V W++G LE +I+ P G L+I Q+ DAG YTC A+NE
Sbjct: 721 MECKTSGIPPPQVKWFKGDLELRPSTFLIIDP---LLGLLKIQETQDLDAGDYTCVAINE 777
Query: 654 LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713
G A+ +I L VG P + P DV++E+G + L C G P PT+ WRR D P+ R
Sbjct: 778 AGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSR 837
Query: 714 LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS 773
S Q +G LF ++ D+ Y+CEA N FGK+Q+E + VTG P I S
Sbjct: 838 --PFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGIS 895
Query: 774 APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHA 833
V+EGQ ++LPC +LAG P+PER W+K+ L ++R+DGSLH++R +
Sbjct: 896 PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDG 955
Query: 834 GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 893
G Y+CVA+N AG+ ++ +VV V P I T EG+P +LPC ASG P P++ W+
Sbjct: 956 GEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS 1015
Query: 894 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIH 953
K+ +++ ++ +G+L + P +++G YVCTATNT G++ ++++L+V +PR+
Sbjct: 1016 KKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVF 1075
Query: 954 MN-GSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSL 1012
+ + + P++++ AGEEVTL CE K PPP++TW K+++ + P + R+ LPSGS+
Sbjct: 1076 GDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSM 1135
Query: 1013 RLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
++ + + DSG Y C A+N AG+ + L V
Sbjct: 1136 KITETRTSDSGMYLCVATNIAGNVTQAVKLNV 1167
Score = 333 bits (854), Expect = 6e-91
Identities = 218/699 (31%), Positives = 321/699 (45%), Gaps = 26/699 (3%)
Query: 343 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 402
LR GE R SG +I A + Y C A + AG + I+ + PP
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGK-TTREFILTVNVPPN 3714
Query: 403 LVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGII 461
+ P ++ + ++ VL C G +TW +D VL + R + L + L I
Sbjct: 3715 IKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAH 3774
Query: 462 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH 521
TD GRY C+A+NA G R + L V P ++ ++ V+ ++C A+G P P
Sbjct: 3775 VTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPS 3834
Query: 522 ISWSRESQAL---QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
I+W + L Q + + + G+L+I + +D Y C TN G D+ TV L
Sbjct: 3835 INWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Query: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGKLRI 635
PPS++ LV AV+ C ASGVP P + W + G+ ++ +G SSG + I
Sbjct: 3895 VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954
Query: 636 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 695
A Q AG YTC A N G A + L V P + P ++ V L LL C ATG
Sbjct: 3955 LATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGT 4014
Query: 696 PPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ 755
P P +TW++ G+ + + + P G+ +V ED Y+C A+N G
Sbjct: 4015 PSPFITWQKE-----GINVNTSGRNHAVLPSGGLQISRAVR-EDAGTYMCVAQNPAGTAL 4068
Query: 756 AEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH 815
+ +L V PP I+ + +P++L C G P P+ W KDGR + R
Sbjct: 4069 GKIKLNV--QVPPVISPHLKEYVIAVDKPITLSCEA-DGLPPPDITWHKDGRAIVESIRQ 4125
Query: 816 SIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVP 875
+ + GSL + AG Y+C+A N AGS +L V VPPRI T H+ NE
Sbjct: 4126 RVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQ 4185
Query: 876 ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
A LPCVA G+P P I W K+ L + Y G L++ +D+G Y C A N
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAA 4245
Query: 936 GFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR 995
G + + L+V+ P +P V+ GE++ L C+A G P P +TWT ++
Sbjct: 4246 GEDTHTVSLTVHVLPTF-------TELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN 4298
Query: 996 PVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
+P + + L + +V DSG Y CTA N G
Sbjct: 4299 IIP--AHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG 4335
Score = 311 bits (796), Expect = 3e-84
Identities = 224/694 (32%), Positives = 303/694 (43%), Gaps = 33/694 (4%)
Query: 365 EILRASKAE---EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP---NVTVSPGETAV 418
E+LR S A+ G Y C A S AG K +V PP + ++TV
Sbjct: 3582 EVLRISTAQVEDTGRYTCLASSPAGDDD-KEYLVRVHVPPNIAGTDEPRDITVLRNRQVT 3640
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD-LSLEISGIIPTDGGRYQCVASNANG 477
L C+ P +TW+R+ L A T RV L+ L+I+ D Y CVASN G
Sbjct: 3641 LECKSDAVPPPVITWLRNGERLQA-TPRVRILSGGRYLQINNADLGDTANYTCVASNIAG 3699
Query: 478 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED-SR 536
T L V P + S + C A G PTP I+W ++ L + +R
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHAR 3759
Query: 537 IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 596
+ G L IQ D G Y C ATN GTD+ + L PPS++ + V V
Sbjct: 3760 YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNV 3819
Query: 597 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTCRAV 651
+ L CEA+G+P P + W + G + + +S SG L I + D TY C
Sbjct: 3820 QTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVT 3879
Query: 652 NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG 711
N GD + L V P + + P D V A++ C A+G P P++ W + G
Sbjct: 3880 NGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKN-----G 3934
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
+RL RG R SG + + Y C ARN G L V H PP I
Sbjct: 3935 IRL-LPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV--HEPPVIQ 3991
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQ 830
+ V+ P+ LPC G P P W K+G + G H++ G L + RA++
Sbjct: 3992 PQPSELHVILNNPILLPCEA-TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVR 4050
Query: 831 EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTI 890
E AG Y CVA N AG+ ++L VQVPP I P ++ P +L C A G+P P I
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDI 4110
Query: 891 TWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
TW K+ A+ V G+L IA DAG Y C A N G SS +L+V+ P
Sbjct: 4111 TWHKDGRAIVE-SIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP 4169
Query: 951 RIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG 1010
RI T + L C A G P P + W KD+ + + +Y P G
Sbjct: 4170 RIRSTEGH-------YTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYG 4222
Query: 1011 SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
L L V + DSG Y C A+N AG +H L V
Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 308 bits (788), Expect = 3e-83
Identities = 232/846 (27%), Positives = 361/846 (42%), Gaps = 47/846 (5%)
Query: 219 LQGVPISLVINSTGLKAPGRLDSVELAQ--SSGKPLLTLPTKPL---SNGSTHQLWGGPP 273
L G + LV N+ G+ P L Q GKP+ + T+ + +NGST ++G
Sbjct: 3259 LLGENVELVCNANGIPTP-------LIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 274 FHTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSV 333
T K + + R+ ++ A ++ + + + C
Sbjct: 3312 SDTGKYTCVATNPAGEED-----RIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRA 3366
Query: 334 HSALPFRLQLRRGEARLGEERHFQE-SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKA 392
P ++ + L H + + I+RA ++ Y C A +RAG
Sbjct: 3367 TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY 3426
Query: 393 QIVVTDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL 450
+ V PP + +TV G + ++C G ++ W+RD + L
Sbjct: 3427 NLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVST 3486
Query: 451 ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--V 508
+ L++ D G+Y C+ASN G L V E P ++ + S V +
Sbjct: 3487 HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPL 3546
Query: 509 KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVG 567
+++C ASG P P ++W ++ + L + ++ G ++ I ED G Y+C A++ G
Sbjct: 3547 ELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606
Query: 568 TDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP 625
D + + PP+++ + + V + L C++ VPPP + W R G + P
Sbjct: 3607 DDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATP 3666
Query: 626 EGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL 682
S G+ L+I A D YTC A N G + E L V P + P+ + + L
Sbjct: 3667 RVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILL 3726
Query: 683 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
+S +L C A G P P +TWR+ DG L AG +R ++G L +S D
Sbjct: 3727 NKSTVLECIAEGVPTPRITWRK-DGAVL-----AGNHARYSILENGFLHIQSAHVTDTGR 3780
Query: 743 YVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
Y+C A N G + L V H PP IA + V+ +L C G P P +W
Sbjct: 3781 YLCMATNAAGTDRRRIDLQV--HVPPSIAPGPTNMTVIVNVQTTLACEA-TGIPKPSINW 3837
Query: 803 LKDGRPLPPGSRHS---IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
K+G L + + + GSL + + Y C TN AG R V+L VQVPP
Sbjct: 3838 RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPP 3897
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQP 919
I T + + PA + C ASGVP P+I WTK L RG Y + G + I
Sbjct: 3898 SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 920 SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
AG Y C A N G + + + L V+ P I P ++ + L CE
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQ-------PSELHVILNNPILLPCE 4010
Query: 980 AKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039
A G+P P +TW K+ V + +LPSG L++++ D+G Y C A NPAG+A +
Sbjct: 4011 ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGK 4070
Query: 1040 YVLGVQ 1045
L VQ
Sbjct: 4071 IKLNVQ 4076
Score = 306 bits (785), Expect = 6e-83
Identities = 224/730 (30%), Positives = 320/730 (43%), Gaps = 53/730 (7%)
Query: 351 GEERHFQESGN-SSWEILRASKAEEGTYECTAVSRAGTGRA--KAQIVVT-------DPP 400
GE + S N S+ I A ++ G Y C A + AG + VT D
Sbjct: 3290 GETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEA 3349
Query: 401 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 460
+L+ + +++ + CR G P + W+++ LP S+ A + I
Sbjct: 3350 EKLMTLVDTSIN------IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRA 3403
Query: 461 IPTDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYP 518
+D Y CVASN GV L V P + S+ T +G ++C G P
Sbjct: 3404 QVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTP 3463
Query: 519 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
P ++W R+ Q L D+ + V G ++ + ED+G Y+C A+NE G + L
Sbjct: 3464 APSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523
Query: 578 TDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK--- 632
+PP + S + + V V L C ASG+P P++ W + G + + + G
Sbjct: 3524 LEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV 3583
Query: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLAC 690
LRI AQ D G YTC A + GD E + V P + T+ PRD+TV R L C
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643
Query: 691 RATGRPPPTVTWRRG----DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746
++ PPP +TW R P L GR + D G D A Y C
Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLG----------DTANYTCV 3693
Query: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806
A N+ GK E I+T + PP I ++ +L + L CI G P P W KDG
Sbjct: 3694 ASNIAGKTTRE--FILTVNVPPNIKGGPQSLVILLNKSTVLECIA-EGVPTPRITWRKDG 3750
Query: 807 RPLPPG-SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA 865
L +R+SI +G LH+ A GRY C+ATN AG+ R ++L V VPP I P
Sbjct: 3751 AVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGP 3810
Query: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALT--SRGPHYNVSKEGTLLIAQPSAQD 923
T+ V +L C A+G+P P+I W K + L Y + G+L+I PS D
Sbjct: 3811 TNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDD 3870
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGS 983
Y CT TN G + + L+V P I A+ P + C A G
Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQVPPSI-------ADEPTDFLVTKHAPAVITCTASGV 3923
Query: 984 PPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLG 1043
P P + WTK+ + P + Y +L SG++ + Q+ +G Y C A N AGSA L
Sbjct: 3924 PFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH 3983
Query: 1044 VQGRTSWQPQ 1053
V QPQ
Sbjct: 3984 VHEPPVIQPQ 3993
Score = 306 bits (784), Expect = 8e-83
Identities = 223/749 (29%), Positives = 347/749 (46%), Gaps = 45/749 (6%)
Query: 323 LHQPLLVSC-SVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA 381
+++ L+ C S S P + G+ L ++ H S +IL + G Y C A
Sbjct: 2886 VNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVA 2945
Query: 382 VSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL 440
+ AG+ + + V PP + P + N+TV L+C V G P +L+W+++ + +
Sbjct: 2946 ENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPI 3005
Query: 441 PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ 500
+T + +L+I +DGG Y C+A N G ++ L V P + H S
Sbjct: 3006 KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSES 3065
Query: 501 ----HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDA 555
+ +G V + C ++ P P I+W + + + E + + + A G ++ I+ D
Sbjct: 3066 LSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDT 3125
Query: 556 GNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEEAVLVCEASGVPPPRVIW 614
G Y C+A N G D + L PPS+ V+V + L C+A+G+PPP + W
Sbjct: 3126 GQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAW 3185
Query: 615 YRG--------GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 666
+ LE+ + GS KL+I +Q D+G YTC A N G A L++
Sbjct: 3186 LKNHKRIENSDSLEVRILSGGS---KLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQ 3242
Query: 667 HAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
P + E+P DV+V LG + L C A G P P + W + DG+P + +G R R
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK-DGKP----IASGETERIRV 3297
Query: 725 PDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS---APTVRVL 780
+G L D Y C A N G+ L V + P I + A + L
Sbjct: 3298 SANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNV--YVTPTIRGNKDEAEKLMTL 3355
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCV 839
+++ C G P P+ +WLK+G PLP S + A G + + RA Y+CV
Sbjct: 3356 VDTSINIECRA-TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCV 3414
Query: 840 ATNTAGSQHRDVELVVQVPPRI-HPTATHHIT-NEGVPASLPCVASGVPAPTITWTKETN 897
A+N AG ++ L V PP + + T IT +G S+ C+ G PAP++ W ++
Sbjct: 3415 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474
Query: 898 ALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNG 956
L H VS G +L + + +D+G Y C A+N G S+ L V P H+NG
Sbjct: 3475 PL-GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP--HING 3531
Query: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLA 1015
S +++ + L C A G P P +TW KD RP+P T++ L G LR++
Sbjct: 3532 SEEHE---EISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRIS 3587
Query: 1016 QVQVGDSGHYECTASNPAGSASHRYVLGV 1044
QV D+G Y C AS+PAG Y++ V
Sbjct: 3588 TAQVEDTGRYTCLASSPAGDDDKEYLVRV 3616
Score = 297 bits (760), Expect = 5e-80
Identities = 221/700 (31%), Positives = 327/700 (46%), Gaps = 38/700 (5%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QLVPAPNVTVSPGETAVLSCRVL 424
I +A + G Y C A + AG + + ++ V PP + V + L C
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Query: 425 GEAPYNLTWVRDWRVLPASTGRVA-QLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++TW++D + + + G + Q + L+I+ + D GRY CVA+NA G T+ +
Sbjct: 1852 GIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHI 1911
Query: 484 WLLVREAPQVSIHTSSQHFSQGV----EVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
L V E P S+ + + ++ V V++ C A+G P P I+W ++++ L + +
Sbjct: 1912 QLHVHEPP--SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTF 1969
Query: 540 DAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEA 598
+G +I I+ DAG Y C A N G + +L PS+S N +V V V
Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPV 2029
Query: 599 VLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGK-LRIPAAQERDAGTYTCRAVNEL 654
L CEA G+P P + W + G + G S G+ L + +AQ D G YTC AVN
Sbjct: 2030 RLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAA 2089
Query: 655 GDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
G+ +I L V P + ++V+V + ++ L C++ PPPT+TW + DG PL +
Sbjct: 2090 GEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLK-DGHPLLKKP 2148
Query: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS- 773
G S + VL E +D Y CEA NV GK E V PP I S
Sbjct: 2149 GL-----SISENRSVLKIEDAQVQDTGRYTCEATNVAGK--TEKNYNVNIWVPPNIGGSD 2201
Query: 774 -APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR---ADGSLHLDRAL 829
+ V+EG +SL C +G P P W K G P+ S +R L + A
Sbjct: 2202 ELTQLTVIEGNLISLLC-ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE 2260
Query: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHH---ITNEGVPASLPCVASGVP 886
+ A YSCVA+N AG+ ++ L V + P I + +H I G SL C G+P
Sbjct: 2261 KSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP 2320
Query: 887 APTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRLS 945
PT+TW K+ + L + + EG +L + D G YVC A N G + ++ LS
Sbjct: 2321 PPTVTWMKDGHPLI-KAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLS 2379
Query: 946 VNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYG 1005
V+ P I N P ++ V+L CEA G P P +TW KD PV ++N
Sbjct: 2380 VHAPPSI----IGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPV-SLSNSVR 2434
Query: 1006 LLPSG-SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
+L G LRL Q + D+G Y C N AG + L V
Sbjct: 2435 ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 289 bits (739), Expect = 1e-77
Identities = 222/721 (30%), Positives = 320/721 (44%), Gaps = 55/721 (7%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT----VSP 413
E+G EI+ A + + G Y C A S AG K ++ V PP + + T V
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP--AIEGGDETSYFIVMV 1748
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 473
L C V G P + W++D +++ G L L I+ ++ G Y+C+A+
Sbjct: 1749 NNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVK-----VSCSASGYPTPHISWSRES 528
N G + + V P + S S+ V VK + C A+G P P I+W ++
Sbjct: 1809 NTAGDHKKEFEVTVHVPPTI----KSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDD 1864
Query: 529 QALQ-EDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV 586
Q + + + + G ++ I EDAG Y+C ATN G Q+ + L+ +PPS+
Sbjct: 1865 QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDA 1924
Query: 587 NAVV--LVAVGEEAVLVCEASGVPPPRVIWYR------GGLEMILAPEGSSSGKLRIPAA 638
++ V V L C+A+G P P + WY+ G M G + I +A
Sbjct: 1925 GKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI---IDIESA 1981
Query: 639 QERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 698
Q DAG Y C A+N G L V AP ++ V V + L C A G P P
Sbjct: 1982 QISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAP 2041
Query: 699 TVTWRRGDGQPL-----GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
++TW + DG P+ GL++ +G +L S D Y C A N G+
Sbjct: 2042 SLTWLK-DGSPVSSFSNGLQVLSG---------GRILALTSAQISDTGRYTCVAVNAAGE 2091
Query: 754 VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS 813
Q + L V + PP I V VL Q V L C A P P WLKDG PL
Sbjct: 2092 KQRDIDLRV--YVPPNIMGEEQNVSVLISQAVELLCQSDA-IPPPTLTWLKDGHPLLKKP 2148
Query: 814 RHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI--HPTATHHIT 870
SI + S L ++ A + GRY+C ATN AG ++ + + VPP I T
Sbjct: 2149 GLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTV 2208
Query: 871 NEGVPASLPCVASGVPAPTITWTKETNAL--TSRGPHYNVSKEGTLLIAQPSAQDAGAYV 928
EG SL C +SG+P P + W K+ + + S G +S L I+ DA Y
Sbjct: 2209 IEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYS 2268
Query: 929 CTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988
C A+N G + +E L V +P I +GS P ++ G+ ++L+CE +G PPP V
Sbjct: 2269 CVASNVAGTAKKEYNLQVYIRPTITNSGSH----PTEIIVTRGKSISLECEVQGIPPPTV 2324
Query: 989 TWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT 1048
TW KD P+ L L+L + V D+G Y C A N AG +Y L V
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPP 2384
Query: 1049 S 1049
S
Sbjct: 2385 S 2385
Score = 280 bits (717), Expect = 5e-75
Identities = 210/704 (29%), Positives = 308/704 (43%), Gaps = 40/704 (5%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
+ S I+ S + TYECT + AG + + V PP + V+ AV++
Sbjct: 3858 SGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917
Query: 421 CRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
C G ++ W ++ R+LP G L+ ++EI GRY CVA NA G
Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDG-YRILSSGAIEILATQLNHAGRYTCVARNAAGSA 3976
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH- 538
V L V E P + S H + + C A+G P+P I+W +E + R H
Sbjct: 3977 HRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHA 4036
Query: 539 VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEA 598
V G L I EDAG Y C A N GT + L PP +S ++AV +
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 599 VLVCEASGVPPPRVIWYRGGLEMI--LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGD 656
L CEA G+PPP + W++ G ++ + SSG L+I Q DAG YTC A N G
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS 4156
Query: 657 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 716
+S +L V P++ TV A+L C A G P P + W++ + + L
Sbjct: 4157 SSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDN-----VLLAN 4211
Query: 717 GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT 776
G + +P G L E+V ED Y C A N G+ L V H P
Sbjct: 4212 LLGKYTAEP-YGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV--HVLPTFTELPGD 4268
Query: 777 VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 836
V + +G+ + L C G PLP+ W + +P S+ L ++R +E +G Y
Sbjct: 4269 VSLNKGEQLRLSCKA-TGIPLPKLTWTFNNNIIP-AHFDSVNGHSELVIERVSKEDSGTY 4326
Query: 837 SCVATNTAGSQHRDVELVVQVPPRIHPT-ATHHITNEGVPASLPCVASGVPAPTITWTKE 895
C A N+ G + V+ PP ++ I G A L C G P PTI W +
Sbjct: 4327 VCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR- 4385
Query: 896 TNALTSRGPHYNVSKE------GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
+G +S G+L I +DAG Y C ATN G + M L++ +
Sbjct: 4386 ------KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP 4439
Query: 950 PRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS 1009
P I + P++ AG ++ L+C+A G P P +TW++ + +R +L +
Sbjct: 4440 PIITLE-------PVETVINAGGKIILNCQATGEPQPTITWSRQGHSI-SWDDRVNVLSN 4491
Query: 1010 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ---GRTSW 1050
SL +A Q D+ +EC A N GS R + VQ G + W
Sbjct: 4492 NSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQW 4535
Score = 276 bits (705), Expect = 1e-73
Identities = 215/711 (30%), Positives = 314/711 (44%), Gaps = 43/711 (6%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV-LSCRVL 424
I +A ++ G Y C A++ AG + V PP P V V V L+C
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDAT 3176
Query: 425 GEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRAS 482
G P + W+++ + + S ++ L+I+ +D G Y C+ASN G +
Sbjct: 3177 GIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKY 3236
Query: 483 VWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQ--EDSRIH 538
+L ++ P V+ S G V++ C+A+G PTP I W ++ + + E RI
Sbjct: 3237 YFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIR 3296
Query: 539 VDAQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVAVG 595
V A G TL I G D G Y+C ATN G + L P++ + A L+ +
Sbjct: 3297 VSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV 3356
Query: 596 EEAVLV-CEASGVPPPRVIWYRGGLEMILAPEG---SSSGKLRIPAAQERDAGTYTCRAV 651
+ ++ + C A+G PPP++ W + GL + L+ ++ +RI AQ D YTC A
Sbjct: 3357 DTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVAS 3416
Query: 652 NELGDASAEIQLAVGHAPQLTEL--PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709
N G + L V P + ++TV G S +AC G P P++ W R DGQP
Sbjct: 3417 NRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLR-DGQP 3475
Query: 710 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
LGL + VL ED Y C A N G+V L V PP
Sbjct: 3476 LGLDAHLTVSTHGM-----VLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL--EPPH 3528
Query: 770 IASSAP--TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS-LHLD 826
I S + V+ P+ L CI +G P P+ W+KDGRPLP + G L +
Sbjct: 3529 INGSEEHEEISVIVNNPLELTCIA-SGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRIS 3587
Query: 827 RALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHITNEGVPASLPCVA 882
A E GRY+C+A++ AG ++ + V VPP I P + N V +L C +
Sbjct: 3588 TAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQV--TLECKS 3645
Query: 883 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQE 941
VP P ITW + L + P + G L I D Y C A+N G +++E
Sbjct: 3646 DAVPPPVITWLRNGERLQAT-PRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTRE 3704
Query: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
L+VN P I P + + L+C A+G P P +TW KD +
Sbjct: 3705 FILTVNVPPNIKGG-------PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNH 3757
Query: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
RY +L +G L + V D+G Y C A+N AG+ R L V S P
Sbjct: 3758 ARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAP 3808
Score = 271 bits (692), Expect = 4e-72
Identities = 222/774 (28%), Positives = 334/774 (43%), Gaps = 79/774 (10%)
Query: 325 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
Q + ++C V + +P + G+ +E H SG +I G Y C A S
Sbjct: 2495 QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASS 2554
Query: 384 RAG-TGRAKAQIVVTDPPPQLVPA----PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR 438
AG R+ + V P V + +VTV L C P +TW +D
Sbjct: 2555 PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT 2614
Query: 439 VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG---------------VTRASV 483
L ++ +L+I + GRY CVA+N G + + +
Sbjct: 2615 PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDL 2674
Query: 484 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG 543
W +V I ++ + + C A P+ +SW ++ Q L+ D +++ A G
Sbjct: 2675 WGPGLSPKEVKIKVNN-------TLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANG 2727
Query: 544 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV------------NAVV 590
TL I+ D G Y+C A+N G D+ + PPS +
Sbjct: 2728 HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAK 2787
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYRGGL------EMILAPEGSSSGKLRIPAAQERDAG 644
V + L CE + PPP + WY+ G ++++ P G L+IP A+ DAG
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGR---VLQIPRAKVEDAG 2844
Query: 645 TYTCRAVNELGDASAEIQLAVGHAPQL----TELPRDVTVELGRSALLACRATGRPPPTV 700
YTC AVNE G+ S + + V P + ++LP +VTV + +SAL+ C ++G P P
Sbjct: 2845 RYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRN 2904
Query: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
+W++ DGQPL + +L + D YVC A N G + L
Sbjct: 2905 SWQK-DGQPL-----LEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNL 2958
Query: 761 IVTGHAPPQ-IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA 819
V H PP I + + V+ +SL C V +G P P+ WLK+ +P+ + I
Sbjct: 2959 NV--HVPPSVIGPKSENLTVVVNNFISLTCEV-SGFPPPDLSWLKNEQPIKLNTNTLIVP 3015
Query: 820 DG-SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI--HPTATHHITN--EGV 874
G +L + RA G Y+C+A N AG + L V VPP I H + + + N EG
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 875 PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATN 933
SL C ++ VP P ITW K +T H + +G +L I + D G YVC A N
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMIT-ESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN 3134
Query: 934 TVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD 993
G + L+V P I R + VTL C+A G PPP + W K+
Sbjct: 3135 VAGRDDKNFHLNVYVPPSIE-GPEREV-----IVETISNPVTLTCDATGIPPPTIAWLKN 3188
Query: 994 SRPVPPITN-RYGLLPSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ + + +L GS L++A+ Q DSG+Y C ASN G A Y L +Q
Sbjct: 3189 HKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQ 3242
Score = 268 bits (684), Expect = 3e-71
Identities = 210/733 (28%), Positives = 309/733 (42%), Gaps = 41/733 (5%)
Query: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
LP + G L + H + + + I +A+ ++ G Y C A + AGT + + V
Sbjct: 1199 LPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Query: 397 TDPP--PQLVPAPNVTVS---PGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 451
+PP L P N T + C G + W+ + R L ++ L
Sbjct: 1259 QEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILE 1318
Query: 452 D-LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--V 508
D L I+ + P D G Y CVA N G T L V P + + S +
Sbjct: 1319 DGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLT 1378
Query: 509 KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVG 567
+ C G P+P I W +++ + E S I G ++ + PEDAG YSC+A N G
Sbjct: 1379 NLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG 1438
Query: 568 TDQETVTLYYTDPPSVSAVN--AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP 625
T Q+ + PP++ N V V + + L C+ G P P + W++ G + L
Sbjct: 1439 TSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGD 1498
Query: 626 EG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT--ELPRDVT 679
L + A+ D G Y C N G + +I+L + P + + D++
Sbjct: 1499 PNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDIS 1558
Query: 680 VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPE 738
V + L C G P P +TW + DGQP+ S++ D G L
Sbjct: 1559 VLINSLIKLECETRGLPMPAITWYK-DGQPI------MSSSQALYIDKGQYLHIPRAQVS 1611
Query: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT---VRVLEGQPVSLPCIVLAGR 795
D A Y C NV G AE V + PP I + T +V+ ++L C AG
Sbjct: 1612 DSATYTCHVANVAG--TAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLEC-KAAGN 1668
Query: 796 PLPERHWLKDGRPLPPGSRHSIRADG-SLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 854
P P WLKDG P+ I A G L + A + G+Y CVAT+ AG + E+
Sbjct: 1669 PSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVD 1728
Query: 855 VQVPPRIH--PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 912
V VPP I ++ I L C +G P PTI W K+ + R +
Sbjct: 1729 VLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR 1788
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
L+IAQ + G Y C A NT G +E ++V+ P I +G + +V K +
Sbjct: 1789 KLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSG-----LSERVVVKY-K 1842
Query: 973 EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASN 1031
V L C A G P P +TW KD +PV + SG L++A+ + D+G Y C A+N
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Query: 1032 PAGSASHRYVLGV 1044
AG L V
Sbjct: 1903 AAGETQQHIQLHV 1915
Score = 268 bits (684), Expect = 3e-71
Identities = 205/698 (29%), Positives = 318/698 (45%), Gaps = 47/698 (6%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYN 430
+ G Y C AV+ AGT K + V PP NV+V + L C V G
Sbjct: 1332 DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391
Query: 431 LTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 489
+ W +D +V +ST + + L++ P D GRY C A N G ++ + V
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKI-LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLV 1450
Query: 490 APQVSIHTSSQHFSQGV---EVKVSCSASGYPTPHISWSRESQAL-QEDSRIHVDAQGTL 545
P + I T+ + V +V + C G P P I W ++ + L D + + +G +
Sbjct: 1451 PPTI-IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509
Query: 546 I-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVC 602
+ ++ D G Y C +N G + + L PPS+ N + V + L C
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 603 EASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNELGDASA 659
E G+P P + WY+ G ++ + + K L IP AQ D+ TYTC N G A
Sbjct: 1570 ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEK 1629
Query: 660 EIQLAVGHAPQLTE----LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL----G 711
+ V + P + E P + V + S L C+A G P P +TW + DG P+
Sbjct: 1630 SFHVDV-YVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK-DGVPVKANDN 1687
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
+R+ AG G + L S D+ Y+C A +V G+ + + + V PP I
Sbjct: 1688 IRIEAG-GKK--------LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL--VPPAIE 1736
Query: 772 SSAPTVR--VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG-SLHLDRA 828
T V+ + L C V G P P WLKDG+ + I +G L + +A
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHV-TGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQA 1795
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA-THHITNEGVPASLPCVASGVPA 887
+ G Y C+A NTAG ++ E+ V VPP I + + + + P +L C+A+G+P
Sbjct: 1796 QVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN 1855
Query: 888 PTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
P+ITW K+ + + + + G +L IA+ +DAG Y C ATN G + Q ++L V
Sbjct: 1856 PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV 1915
Query: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
+ P + +A L T V L+C+A G+P P++TW KD+R + T+ L
Sbjct: 1916 HEPPSLE-----DAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFL 1970
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
+ + Q+ D+G Y+C A N AG+ Y L V
Sbjct: 1971 NRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQV 2008
Score = 266 bits (681), Expect = 7e-71
Identities = 207/719 (28%), Positives = 308/719 (42%), Gaps = 40/719 (5%)
Query: 350 LGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV 409
+G R+ S + + I A+ + G Y C A + AGT + + + + P +V +
Sbjct: 653 VGSHRYRMTSDGTLF-IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSEL 711
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 468
V+ G+ V+ C+ G P + W + D + P++ + L L L+I D G Y
Sbjct: 712 LVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGL-LKIQETQDLDAGDY 770
Query: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
CVA N G + L V P + G V + C GYP P I W R
Sbjct: 771 TCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLD 830
Query: 529 QALQEDSRIHVDA-----QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD--PP 581
V + G L I + D G Y C+A N+ G Q T+ T P
Sbjct: 831 NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP 890
Query: 582 SVSAVNAVVLVAVGEEAVLVCEA-SGVPPPRVIWYRGGLEMILAPEGS--SSGKLRIPAA 638
+ +V V G++ L C +G P P W + ++ P + S G L I
Sbjct: 891 LIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERV 950
Query: 639 QERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 698
Q +D G YTC A N G + + V P + + ++ G L C+A+G P P
Sbjct: 951 QLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKP 1010
Query: 699 TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEA 758
+V W + G + S D G L+ S E+ YVC A N G + +
Sbjct: 1011 SVIWSKK-----GELISTSSAKFSAGAD-GSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064
Query: 759 RLIVTGHAPPQI-------ASSAPT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
+L V + P++ + P + VL G+ V+LPC V + P P W K+ + +
Sbjct: 1065 QLTV--YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKS-LPPPIITWAKETQLIS 1121
Query: 811 PGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI 869
P S RH+ GS+ + +G Y CVATN AG+ + V+L V VPP+I H
Sbjct: 1122 PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLK 1181
Query: 870 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929
G +PC A G P P ITW+K + + G H+ + +GTL I Q + DAG Y C
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC 1241
Query: 930 TATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAK---AGEEVTLDCEAKGSPPP 986
ATN G E+ L V P + + P T + A + + C AKG+P P
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTV-----EDLEPPYNTTFQERVANQRIEFPCPAKGTPKP 1296
Query: 987 LVTWTKDSRPVPPITNRYGLLPSGSLR-LAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
+ W + R + +L G+L +A V D+G Y C A N AG+ +Y L V
Sbjct: 1297 TIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKV 1355
Score = 262 bits (670), Expect = 1e-69
Identities = 214/723 (29%), Positives = 315/723 (43%), Gaps = 46/723 (6%)
Query: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV 418
SG + A ++ G Y C AV+ AG + + V PP + NV+V +
Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE 2122
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
L C+ P LTW++D L G L+I D GRY C A+N G
Sbjct: 2123 LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 479 TRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS- 535
T + + + P + S + +G + + C +SG P P++ W ++ + DS
Sbjct: 2183 TEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2242
Query: 536 -RIHVDAQGTLIIQGVAPE-DAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA---VV 590
R+ + + G + +A + DA YSC A+N GT ++ L P+++ + +
Sbjct: 2243 GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP--EGSSSGK-LRIPAAQERDAGTYT 647
+V G+ L CE G+PPP V W + G +I A E G L++ D G Y
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362
Query: 648 CRAVNELGDASAEIQLAVGHAPQLT---ELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
C AVN G + L+V P + P +++V S L C A+G P P++TW +
Sbjct: 2363 CVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK 2422
Query: 705 GDGQPLGLR-----LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR 759
DG P+ L L GR R Q ED Y C RN G+ +
Sbjct: 2423 -DGWPVSLSNSVRILSGGRMLRLMQ----------TTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 760 LIVTGHAPPQIA--SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSI 817
L V PP I ++ V+V E Q V+L C V G P+PE W KDG+PL H I
Sbjct: 2472 LSVL--VPPHIVGENTLEDVKVKEKQSVTLTCEV-TGNPVPEITWHKDGQPLQEDEAHHI 2528
Query: 818 RADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI-------HPTATHHI 869
+ G L + H GRY+C+A++ AG + R L V V P I +P I
Sbjct: 2529 ISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVI 2588
Query: 870 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929
N P SL C A P TITW K+ L S + TL I +AG Y C
Sbjct: 2589 LNS--PTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646
Query: 930 TATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV-PLQVTAKAGEEVTLDCEAKGSPPPLV 988
ATN G + + V P I+ + P +V K +TL+CEA P +
Sbjct: 2647 VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 989 TWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT 1048
+W KD +P+ + +L++ + Q+ D+G Y C ASN AG + + +Q
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1049 SWQ 1051
S+Q
Sbjct: 2767 SFQ 2769
Score = 257 bits (656), Expect = 5e-68
Identities = 204/740 (27%), Positives = 313/740 (42%), Gaps = 39/740 (5%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
+ S +I ++ G Y C A + AG ++ V PP ++ V G+ +
Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIP 1191
Query: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
C G +TW + + D +L I P+D G Y CVA+N G
Sbjct: 1192 CNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE 1251
Query: 481 ASVWLLVREAPQVS-----IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-ED 534
+ L V+E P V +T+ Q ++ C A G P P I W + L +
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311
Query: 535 SRIHVDAQGTL-IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAV--VL 591
I + GTL +I V P D G Y C A NE GT + L PP + V V
Sbjct: 1312 PGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVS 1371
Query: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP--EGSSSGK-LRIPAAQERDAGTYTC 648
V + + L CE G P P ++WY+ +++ + + ++GK L++ A DAG Y+C
Sbjct: 1372 VLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSC 1431
Query: 649 RAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRRGD 706
+A+N G + + V P + T P +V+V L R L C+ G P P + W + D
Sbjct: 1432 KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFK-D 1490
Query: 707 GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 766
G+PL L G + VL ++ D+ Y C N GK + +L + +
Sbjct: 1491 GKPLFL----GDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI--YI 1544
Query: 767 PPQIASSAPT--VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS-L 823
PP I T + VL + L C G P+P W KDG+P+ S+ G L
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLEC-ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYL 1603
Query: 824 HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA---SLPC 880
H+ RA + Y+C N AG+ + + V VPP I + + V A +L C
Sbjct: 1604 HIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLEC 1663
Query: 881 VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSS 939
A+G P+P +TW K+ + + G L I D G Y+C AT+ G
Sbjct: 1664 KAAGNPSPILTWLKD-GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Query: 940 QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
+ + V P I G + + V + LDC GSPPP + W KD + +
Sbjct: 1723 IKYEVDVLVPPAIE-GGDETSYFIVMV----NNLLELDCHVTGSPPPTIMWLKDGQLIDE 1777
Query: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG----RTSWQPQSL 1055
LL L +AQ QV ++G Y C A+N AG + + V ++S + +
Sbjct: 1778 RDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERV 1837
Query: 1056 PVPHHPACLSGLSVPLLQPT 1075
V + P L ++ + P+
Sbjct: 1838 VVKYKPVALQCIANGIPNPS 1857
Score = 255 bits (651), Expect = 2e-67
Identities = 186/622 (29%), Positives = 274/622 (44%), Gaps = 25/622 (4%)
Query: 324 HQPLLVSCSVHSALPF-RLQLRRGEARL---GEERHFQESGNSSWEILRASKAEEGTYEC 379
H P +++C+ S +PF + + RL G+ SG + EIL G Y C
Sbjct: 3911 HAPAVITCTA-SGVPFPSIHWTKNGIRLLPRGDGYRILSSG--AIEILATQLNHAGRYTC 3967
Query: 380 TAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 439
A + AG+ + V +PP + V +L C G +TW ++
Sbjct: 3968 VARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027
Query: 440 LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS 499
+ S A L L+IS + D G Y CVA N G + L V+ P +S H
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Query: 500 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559
+ + +SC A G P P I+W ++ +A+ E R V + G+L I V P DAG+Y+
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
C A N G+ + L PP + + V +A+L C A G+P P + W + +
Sbjct: 4148 CMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNV 4207
Query: 620 ---EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPR 676
++ G+L + D+G YTC A N G+ + + L V P TELP
Sbjct: 4208 LLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG 4267
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
DV++ G L+C+ATG P P +TW + + + G L E V+
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNI-IPAHFDSVNGHSE-------LVIERVS 4319
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT--VRVLEGQPVSLPCIVLAG 794
ED YVC A N G V+A + V PP P+ + L G + L C V G
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVK--EPPVFKGDYPSNWIEPLGGNAI-LNCEV-KG 4375
Query: 795 RPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 854
P P W + G + R +GSL + + E AG Y+CVATN AG R + L
Sbjct: 4376 DPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 855 VQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTL 914
+Q PP I + N G L C A+G P PTITW+++ +++ S NV +L
Sbjct: 4436 LQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI-SWDDRVNVLSNNSL 4494
Query: 915 LIAQPSAQDAGAYVCTATNTVG 936
IA +D + C A N +G
Sbjct: 4495 YIADAQKEDTSEFECVARNLMG 4516
Score = 243 bits (621), Expect = 6e-64
Identities = 207/754 (27%), Positives = 312/754 (41%), Gaps = 62/754 (8%)
Query: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV---PAPNVTVSPGE 415
SG +++ + + G Y C + AG R + V PP +V +V V +
Sbjct: 2437 SGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVL-VPPHIVGENTLEDVKVKEKQ 2495
Query: 416 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475
+ L+C V G +TW +D + L L+I+ + GRY C+AS+
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555
Query: 476 NGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQ 529
G S L V +P ++ S + V V ++ C A YP I+W ++
Sbjct: 2556 AGHKSRSFSLNVFVSPTIA-GVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT 2614
Query: 530 ALQEDSRIHVDAQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA 588
L+ + I + G TL I ++AG YSC ATNE G + + PP ++ +
Sbjct: 2615 PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDL 2674
Query: 589 --------VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPA 637
V + V L CEA +P + WY+ G + ++ L+I
Sbjct: 2675 WGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKE 2734
Query: 638 AQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL--------------PRDVTVELG 683
AQ D G YTC A N G+ + + + P +L +DV +
Sbjct: 2735 AQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP 2794
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
S L C PPPT+TW + DG PL P VL ED Y
Sbjct: 2795 IS--LYCETNAAPPPTLTWYK-DGHPL-----TSSDKVLILPGGRVLQIPRAKVEDAGRY 2846
Query: 744 VCEARNVFGK--VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH 801
C A N G+ +Q + R++V + V VL + + C+ +G P P
Sbjct: 2847 TCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLS-SGSPAPRNS 2905
Query: 802 WLKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 860
W KDG+PL H ++G L + GRY CVA NTAGS + L V VPP
Sbjct: 2906 WQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965
Query: 861 IHPTATHHIT---NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 917
+ + ++T N + SL C SG P P ++W K + V TL I
Sbjct: 2966 VIGPKSENLTVVVNNFI--SLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQII 3023
Query: 918 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977
+ D G Y C A N G S ++ L+V P I + S + +V V + G V+L+
Sbjct: 3024 RAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV---VNVREGTSVSLE 3080
Query: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
CE+ PPP++TW K+ R + T+ L L + + +V D+G Y C A N AG
Sbjct: 3081 CESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1038 HRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPL 1071
+ L V + P S+ P + +S P+
Sbjct: 3141 KNFHLNV-----YVPPSIEGPEREVIVETISNPV 3169
Score = 229 bits (585), Expect = 9e-60
Identities = 187/668 (27%), Positives = 293/668 (43%), Gaps = 37/668 (5%)
Query: 395 VVTDPPPQLVP--APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD 452
+V D P +P P + PG+ + C V P+ L++VR+ L + + A
Sbjct: 426 IVPDAPKVTMPEKTPGYYLQPGQ---IPCSVDSLLPFTLSFVRNGVTLGVDQ-YLKESAS 481
Query: 453 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 512
++L+I+ + +D G Y+C+A ++ G RA + V E P V ++ + G ++C
Sbjct: 482 VNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTC 541
Query: 513 SASGYPTPHISWSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ 570
+++W R + L E +RI A +L ++ V DAG Y C ++E G+
Sbjct: 542 LIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSA 601
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG--S 628
+V L +PP V+ + G E ++C A+G P P++ W + ++ + +
Sbjct: 602 ASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT 661
Query: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
S G L I A +DAG Y C A N G L AP+L + ++ V LG ++
Sbjct: 662 SDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVM 721
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
C+ +G PPP V W +GD L LR P G+L + D Y C A
Sbjct: 722 ECKTSGIPPPQVKWFKGD---LELRPST---FLIIDPLLGLLKIQETQDLDAGDYTCVAI 775
Query: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK---- 804
N G+ + L V +PP V + G V+LPC V G P P W +
Sbjct: 776 NEAGRATGKITLDVG--SPPVFIQEPADVSMEIGSNVTLPCYV-QGYPEPTIKWRRLDNM 832
Query: 805 --DGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ--VPPR 860
RP S +R G+L + G Y C A N G + + V V P
Sbjct: 833 PIFSRPFSVSSISQLRT-GALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 861 IHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQP 919
I + + EG +LPC + +G P P W K + A+ + P+ V +G+L I +
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNS-AMLLQNPYITVRSDGSLHIERV 950
Query: 920 SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
QD G Y C A+N G +++ + V+ P I + + G VTL C+
Sbjct: 951 QLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIE-------GIPVTLPCK 1003
Query: 980 AKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039
A G+P P V W+K + + ++ GSL + +SG Y CTA+N AG A +
Sbjct: 1004 ASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRK 1063
Query: 1040 YVLGVQGR 1047
L V R
Sbjct: 1064 VQLTVYVR 1071
Score = 208 bits (529), Expect = 3e-53
Identities = 160/553 (28%), Positives = 250/553 (45%), Gaps = 18/553 (3%)
Query: 311 PLVSMAP-RIHGYLHQPLLVSC-SVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR 368
P++ P +H L+ P+L+ C + + PF + G R+ + +I R
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISR 4047
Query: 369 ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP 428
A + + GTY C A + AGT K ++ V PP ++ + LSC G P
Sbjct: 4048 AVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPP 4107
Query: 429 YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
++TW +D R + S R L+ SL+I+ + P D G Y C+A+N G + S L V
Sbjct: 4108 PDITWHKDGRAIVESI-RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVH 4166
Query: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED-SRIHVDAQGTLII 547
P++ ++ + + C A G PTP I+W +++ L + + G LI+
Sbjct: 4167 VPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELIL 4226
Query: 548 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 607
+ V ED+G Y+C A N G D TV+L P+ + + V + GE+ L C+A+G+
Sbjct: 4227 ENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGI 4286
Query: 608 PPPRVIWYRGGLEMILAPEGSSSG--KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
P P++ W +I A S +G +L I + D+GTY C A N +G A + V
Sbjct: 4287 PLPKLTWTFNN-NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV 4345
Query: 666 GHAPQLT-ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
P + P + LG +A+L C G P PT+ W R G + + R RQ
Sbjct: 4346 KEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR-KGVDIEI------SHRIRQ 4398
Query: 725 PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQP 784
+G L ED Y C A N G V E + +T +PP I + G
Sbjct: 4399 LGNGSLAIYGTVNEDAGDYTCVATNEAGVV--ERSMSLTLQSPPIITLEPVETVINAGGK 4456
Query: 785 VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA 844
+ L C G P P W + G + R ++ ++ SL++ A +E + CVA N
Sbjct: 4457 IILNCQA-TGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLM 4515
Query: 845 GSQHRDVELVVQV 857
GS V ++VQV
Sbjct: 4516 GSVLVRVPVIVQV 4528
Score = 172 bits (437), Expect = 1e-42
Identities = 122/459 (26%), Positives = 199/459 (43%), Gaps = 18/459 (3%)
Query: 315 MAPRIHGYL---HQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASK 371
++P + Y+ +P+ +SC P + + + E + + S +I
Sbjct: 4081 ISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP 4140
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 431
+ G Y C A + AG+ ++ V PP + TV+ A+L C G +
Sbjct: 4141 GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI 4200
Query: 432 TWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
W +D +L G+ L + ++ D G Y CVA+NA G +V L V P
Sbjct: 4201 NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP 4260
Query: 492 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQGTLIIQG 549
+ ++G ++++SC A+G P P ++W+ + + DS V+ L+I+
Sbjct: 4261 TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS---VNGHSELVIER 4317
Query: 550 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSA-VNAVVLVAVGEEAVLVCEASGVP 608
V+ ED+G Y C A N VG + +Y +PP + + +G A+L CE G P
Sbjct: 4318 VSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDP 4377
Query: 609 PPRVIWYRGGLEMILAP--EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 666
P + W R G+++ ++ +G L I DAG YTC A NE G + L +
Sbjct: 4378 TPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQ 4437
Query: 667 HAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 726
P +T P + + G +L C+ATG P PT+TW R G + R
Sbjct: 4438 SPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSR-QGHSISW------DDRVNVLS 4490
Query: 727 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 765
+ L+ ED + + C ARN+ G V +IV H
Sbjct: 4491 NNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVH 4529
Score = 130 bits (327), Expect = 8e-30
Identities = 96/347 (27%), Positives = 152/347 (43%), Gaps = 9/347 (2%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 432
+ G Y C A + AG + V P +V+++ GE LSC+ G LT
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT 4292
Query: 433 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 492
W + ++PA V ++L +E + D G Y C A N+ G +A ++ V+E P
Sbjct: 4293 WTFNNNIIPAHFDSVNGHSELVIE--RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV 4350
Query: 493 VSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA 551
S G ++C G PTP I W+R+ ++ RI G+L I G
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTV 4410
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 611
EDAG+Y+C ATNE G + +++L PP ++ ++ G + +L C+A+G P P
Sbjct: 4411 NEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPT 4470
Query: 612 VIWYRGGLEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---G 666
+ W R G + + S+ L I AQ+ D + C A N +G + + V G
Sbjct: 4471 ITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHG 4530
Query: 667 HAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713
Q + R +V G+ R +P P + G L +R
Sbjct: 4531 GFSQWSAW-RACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMR 4576
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 324 bits (830), Expect = 4e-88
Identities = 236/724 (32%), Positives = 331/724 (45%), Gaps = 49/724 (6%)
Query: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 2244 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2299
Query: 397 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 454
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 2300 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 2352
Query: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 511
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 2353 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 2411
Query: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 570
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 2412 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2471
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI-------L 623
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 2472 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2531
Query: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
PEGS LRI +DAG Y C A N G L V P + P ++T+
Sbjct: 2532 LPEGS----LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
ALL C A+G P P V W + DGQ L RL G R S L + P+D A +
Sbjct: 2588 TPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGA---YRLLPSNALLLTAPGPQDSAQF 2643
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
C N G +A VT H PP IA V PV L C G P P W
Sbjct: 2644 ECVVSNEVG--EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWS 2700
Query: 804 KDGRPLPP-GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH 862
K G L GS + + G+L + +AL HAGRY+C A N+AG H+ V L VQ P +
Sbjct: 2701 KAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVK 2760
Query: 863 P--TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
P + + E V LPC ASG+P PTITW KE + G V G L IA S
Sbjct: 2761 PLPSVVRAVAEEEV--LLPCEASGIPRPTITWQKE-GLNVATGVSTQVLPGGQLRIAHAS 2817
Query: 921 AQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
+DAG Y+C A N+ G + + RL V P I NG + ++ G L C+A
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD------LSTTEGSHAFLPCKA 2870
Query: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1040
+GSP P +TW KD +PV ++ + PSG L + ++ D+G Y CTA N G A R
Sbjct: 2871 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRV 2930
Query: 1041 VLGV 1044
L +
Sbjct: 2931 HLTI 2934
Score = 315 bits (806), Expect = 2e-85
Identities = 218/687 (31%), Positives = 316/687 (45%), Gaps = 32/687 (4%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTV--SPG 414
E+ + + +LR A G Y C A S AG ++ V PP + P P V +PG
Sbjct: 2349 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2406
Query: 415 ETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
+ VL C V E +TW RD VL L++ + D G Y C A N
Sbjct: 2407 QL-VLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2465
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
A G T + + + P + + + S + C A G P P +SW ++ L
Sbjct: 2466 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2525
Query: 535 S-RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
S R + +G+L IQ V +DAG+Y C A+N G+D++ L +PP+++ + + +
Sbjct: 2526 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLT 2585
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTC 648
A+L CEASG P P V+W++ G ++ + + S L + A +D+ + C
Sbjct: 2586 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 2645
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
NE+G+A Q+ V P + + D TV + +L C +TG P PTV+W +
Sbjct: 2646 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA--- 2702
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
G +LGA RGS R SG L P Y C ARN G A + +T A P
Sbjct: 2703 --GAQLGA-RGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV--AHKHVFLTVQASP 2757
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA 828
+ VR + + V LPC +G P P W K+G + G + G L + A
Sbjct: 2758 VVKPLPSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHA 2816
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
E AG Y C+A N+AGS LVVQVPP I T EG A LPC A G P P
Sbjct: 2817 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP 2876
Query: 889 TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT 948
ITW K+ ++ + + G LL+ QDAG Y CTA N VG + + + L++
Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2936
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP-ITNRYGLL 1007
P +P + + G+ + L C A+GSP P + WT + RPV ++ + G
Sbjct: 2937 LPVF-------TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-- 2987
Query: 1008 PSGSLRLAQVQVGDSGHYECTASNPAG 1034
+L+ A V DSG Y C A N G
Sbjct: 2988 -GSTLQRAAVSREDSGTYVCWAENRVG 3013
Score = 287 bits (735), Expect = 4e-77
Identities = 225/785 (28%), Positives = 343/785 (43%), Gaps = 38/785 (4%)
Query: 317 PRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEER-HFQESGNSSWEILRASKAEEG 375
P ++ ++Q L+ C + R+ L F+ S I + G
Sbjct: 2489 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2548
Query: 376 TYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWV 434
Y C A + AG+ R + V +PP + P+P N+T++ A+L C G + W
Sbjct: 2549 HYLCLASNSAGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2607
Query: 435 RDWRVLP--ASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 492
+D + L G L +L ++ P D +++CV SN G + V P
Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667
Query: 493 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL-QEDSRIHVDAQGTLIIQGVA 551
++ + + V ++C ++G P P +SWS+ L S V G L I
Sbjct: 2668 IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQAL 2727
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 611
P AG Y+C A N G + V L P V + +VV EE +L CEASG+P P
Sbjct: 2728 PIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT 2787
Query: 612 VIWYRGGLEMI--LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
+ W + GL + ++ + G+LRI A DAG Y C A N G A + +L V P
Sbjct: 2788 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP 2847
Query: 670 QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 729
+ D++ G A L C+A G P P +TW + DGQP+ G + QP SG
Sbjct: 2848 VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVS----GAEGKFTIQP-SGE 2901
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLP 788
L +++ +D Y C A N G+ + L + + ++ P R L G + L
Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL---VLPVFTTLPGDRSLRLGDRLWLR 2958
Query: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL--QEHAGRYSCVATNTAGS 846
C G P P W + RP+ G DG L RA +E +G Y C A N G
Sbjct: 2959 CAA-RGSPTPRIGWTVNDRPVTEGVSEQ---DGGSTLQRAAVSREDSGTYVCWAENRVGR 3014
Query: 847 QHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ V+ P + A ++ G L CV G P P I W K+ L RG H
Sbjct: 3015 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD--GLPLRGSH 3072
Query: 906 YNVS-KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ G+L I + DAG Y C A N +G + + + L + + P + P
Sbjct: 3073 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE-------PQ 3125
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
+T ++G++V L C+A G P P + W + +P+ + R LP GSL L V+ GD+G
Sbjct: 3126 DMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGT 3184
Query: 1025 YECTASNPAGSASHRYVLGVQG--RTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLC 1082
Y+C A N GSA+ R L V+G + SW + + ++ L+ ++Q V
Sbjct: 3185 YDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSI 3244
Query: 1083 HLSLR 1087
H S+R
Sbjct: 3245 HSSIR 3249
Score = 285 bits (729), Expect = 2e-76
Identities = 226/698 (32%), Positives = 312/698 (44%), Gaps = 52/698 (7%)
Query: 360 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAV 418
G EI A +++G Y C + AG + V PP P V+ G V
Sbjct: 1893 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV 1952
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
L+C V G +TW++D + +S L++S + P G Y CVA N
Sbjct: 1953 LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 2012
Query: 479 TRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS- 535
R + V AP++ S H +G EV++ C A G P P ++W ++ L +D
Sbjct: 2013 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 2072
Query: 536 ---RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS--AVNAVV 590
R ++D G+L+++G+ DAG Y+C A N G D T+ PP++ A +
Sbjct: 2073 PHLRFYLDG-GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 2131
Query: 591 LVA-VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTY 646
LV+ GE +VC G PP V W + GL + L+ G LRI Q DAG +
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 2191
Query: 647 TCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
TC A + G A L V P L E DV V G L C A G P P V+W +
Sbjct: 2192 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK 2251
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSGV-LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG+PL S+ + G L E+V D Y C A + G+ + +L V
Sbjct: 2252 -DGEPL----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 2300
Query: 764 GHAPPQIASSA-PT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP I S PT + + G P+ L C G P P W KDG+ L R +
Sbjct: 2301 --EPPHIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALT-------RLEN 2350
Query: 822 SLHLDRALQ-EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL-- 878
+ R L+ AG Y+C+A + AG+ + + VQ PP I P L
Sbjct: 2351 NSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 2410
Query: 879 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQP-SAQDAGAYVCTATNTVGF 937
C PAP ITW ++ L H + G L Q S D+G Y CTA N G
Sbjct: 2411 ECSVEAEPAPKITWHRDGIVL-QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2469
Query: 938 SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
+S R+ ++T P I +G NV + TA L C+A G P PLV+W KD P+
Sbjct: 2470 TSVAFRVEIHTVPTIR-SGPPAVNVSVNQTA------LLPCQADGVPAPLVSWRKDRVPL 2522
Query: 998 PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
P + R+ +LP GSLR+ V D+GHY C ASN AGS
Sbjct: 2523 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2560
Score = 283 bits (725), Expect = 5e-76
Identities = 224/766 (29%), Positives = 335/766 (43%), Gaps = 46/766 (6%)
Query: 306 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 360
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 417
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 2083 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140
Query: 418 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 477
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2200
Query: 478 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 2201 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2259
Query: 535 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 592
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 2260 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 2316
Query: 593 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 2317 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 2372
Query: 653 ELGDASAEIQLAVGHAPQLT--ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 710
G ++ V P + PR V +L C P P +TW R DG L
Sbjct: 2373 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVL 2431
Query: 711 GLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
+ ++ P+ G L ++++ D Y C ARN G R+ + H P
Sbjct: 2432 Q------EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI--HTVPT 2483
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRA 828
I S P V V Q LPC G P P W KD PL P S R I +GSL +
Sbjct: 2484 IRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPV 2542
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
L + AG Y C+A+N+AGS + +L V PP I P+ ++ PA LPC ASG P P
Sbjct: 2543 LAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 2602
Query: 889 TITWTKETNALTSRGPH--YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+ W K+ L R Y + LL+ P QD+ + C +N VG + + +++V
Sbjct: 2603 LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 2662
Query: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
+ P I A+ T V L C + G P P V+W+K + + Y +
Sbjct: 2663 HVPPTI-------ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2715
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
PSG+L + Q +G Y C+A N AG A L VQ +P
Sbjct: 2716 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKP 2761
Score = 276 bits (706), Expect = 9e-74
Identities = 231/778 (29%), Positives = 331/778 (42%), Gaps = 69/778 (8%)
Query: 311 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 365
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 786 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 845
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 425
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 846 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 905
Query: 426 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 906 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNL 965
Query: 486 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 542
V AP + S + +G +SC G P P ISW ++ Q L + HV A
Sbjct: 966 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 1025
Query: 543 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 598
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 1085
Query: 599 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 1086 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 1142
Query: 653 ELGDASAEIQLAVGHAPQLT---ELPRDVTVELGRSALLACRATGRPPPTVTWRRGD--- 706
G A + +L+V P+L + ++T L L C A G PPP + W RG+
Sbjct: 1143 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV 1202
Query: 707 --GQPLGLRLGAG--RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
G+ L G + +++++ DSG+ Y C A N G +A V
Sbjct: 1203 SPGEDTYLLAGGWMLKMTQTQEQDSGL-------------YSCLASNEAG--EARRNFSV 1247
Query: 763 TGHAPPQIASS--APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
PP I + ++VL+GQ L C V G P P+ W KDGRPL G H I D
Sbjct: 1248 EVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKLTWFKDGRPLARGDAHHISPD 1306
Query: 821 GSL-HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHIT-NEGV 874
G L + +A AG YSC+A N G + + +L V + P I +A +T
Sbjct: 1307 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1366
Query: 875 PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-------IAQPSAQDAGAY 927
P SL C A P+P ITW K+ G + S+ LL I +DAG Y
Sbjct: 1367 PISLICEALAFPSPNITWMKD-------GAPFEASRNIQLLPGTHGLQILNAQKEDAGQY 1419
Query: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
C TN +G + + + V P I + +V K +TL+CE+ PPP
Sbjct: 1420 TCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT 1479
Query: 988 VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ W KD +PV P + L L++ QV DSG Y C A+N AG + + +Q
Sbjct: 1480 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1537
Score = 269 bits (688), Expect = 1e-71
Identities = 249/863 (28%), Positives = 360/863 (41%), Gaps = 90/863 (10%)
Query: 351 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 407
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 262 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 315
Query: 408 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 460
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 316 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372
Query: 461 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE---VKVSCSASGY 517
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 432
Query: 518 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 433 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 492
Query: 577 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGK 632
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 552
Query: 633 -LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH--APQLTELPRDVTVELGRSALLA 689
L I + +G + C+A NE G A AE++++V AP + E+P G +
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIG-QYHWGXEHHSS 611
Query: 690 CRATGRPPPTVTWRRGDGQPL-------GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
A PP W PL G G G L E V D+
Sbjct: 612 FPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGI 671
Query: 743 YVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
Y C A N+ G+ + E L V PP I VLE V+L C+ +G P P+ W
Sbjct: 672 YTCAATNLAGESKREVALKVL--VPPNIEPGPVNKAVLENASVTLECLA-SGVPPPDVSW 728
Query: 803 LKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861
K +P+ ++ DG L +++A AG Y CVA+N AGS L V VPPRI
Sbjct: 729 FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRI 788
Query: 862 H-PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG-PHYNVSKEGTLL-IAQ 918
P + P L C A+G P+PT+ W K+ N ++ G P V G +L +A
Sbjct: 789 TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLAS 848
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC 978
A D+G Y C A + VG Q++ L V+ P I L V+ A E V L+C
Sbjct: 849 ARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI-------LGEELNVSVVANESVALEC 901
Query: 979 EAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1038
++ PPP+++W KD RP+ P + L++ + V D+GHY C A N AG +
Sbjct: 902 QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEK 961
Query: 1039 RYVLGVQGRTSWQPQSLPVPH---------HPACLS----GLSVPLL------QPTP-RS 1078
Y L V W P+ HP LS G+ P + QP P
Sbjct: 962 HYNLNV-----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 1016
Query: 1079 VRLCHLSL--------RAPLPPPFATPTSCLSQACLSSSTLSLHLS-PYPLRGPGDAVQR 1129
L H+S +A L C + SS L L + P + GP +
Sbjct: 1017 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP----RE 1072
Query: 1130 PPTTQGRAQWGPGFGRTGVRGEP 1152
PPT Q G G+P
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKP 1095
Score = 268 bits (686), Expect = 2e-71
Identities = 234/784 (29%), Positives = 326/784 (41%), Gaps = 89/784 (11%)
Query: 323 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 378
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 1231
Query: 379 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 434
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 1289
Query: 435 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 494
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 1290 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 1348
Query: 495 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 546
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 1349 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 1407
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGE------- 596
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V E
Sbjct: 1408 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 1464
Query: 597 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 653
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 1465 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1524
Query: 654 LGDASAEIQLAVGHAPQLTE----------LPRDVTVELG----------RSALLACRAT 693
G+ + + + P + L R+ G A L C
Sbjct: 1525 AGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN 1584
Query: 694 GRPPPTVTWRRGDGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
PPP +TW R D QPL G + +G R VL V E+ Y C+A N
Sbjct: 1585 AIPPPDLTWYRED-QPLSAGDEVSVLQGGR-------VLQIPLVRAENAGRYSCKASNEV 1636
Query: 752 GKVQAEARLIVTGHAPPQIASSAPT----VRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
G+ L+V PP I V V VSL C L G P+P WL++G
Sbjct: 1637 GEDWLHYELLVL--TPPVILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTISWLQNGL 1693
Query: 808 PLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTAT 866
P P R + DG L + A A Y CVA N AGS + L VQVPPRI
Sbjct: 1694 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 1753
Query: 867 HHIT---NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 923
+T N V SLPC P P +TW K++ AL+ + + TL + + D
Sbjct: 1754 EQVTAILNSSV--SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSD 1811
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHM--NGSRNANVPLQVTAKAGEEVTLDCEAK 981
+G Y C A N G + ++LSV P G ++A V + G++ L CE
Sbjct: 1812 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDA-----VLVRVGDKAVLSCETD 1866
Query: 982 GSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
P P VTW KD +P+ L L + + QV D G Y C SN AG A +
Sbjct: 1867 ALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1926
Query: 1042 LGVQ 1045
L VQ
Sbjct: 1927 LTVQ 1930
Score = 258 bits (660), Expect = 2e-68
Identities = 201/700 (28%), Positives = 310/700 (44%), Gaps = 45/700 (6%)
Query: 375 GTYECTAVSRAGTGRAKAQIVVTDP-PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTW 433
G + C A + AGT A+ ++ V P ++ P G S + P + W
Sbjct: 565 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 624
Query: 434 --------VRDWRVLPASTGR-----VAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
V W + G VA L+I + D G Y C A+N G ++
Sbjct: 625 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 684
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
V L V P + ++ + V + C ASG P P +SW + Q + + V
Sbjct: 685 REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVS 744
Query: 541 AQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV-LVAVGEEA 598
G ++ I+ DAG+Y C A+N G+ + L PP ++ ++ V V
Sbjct: 745 VDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPV 804
Query: 599 VLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-------LRIPAAQERDAGTYTCRAV 651
L C A+G P P ++W + G + +P G+ + L + +A+ D+G Y+C AV
Sbjct: 805 RLTCNATGAPSPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 862
Query: 652 NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG 711
+ +G+ ++ L V P + +V+V S L C++ PPP ++W + DG+PL
Sbjct: 863 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLE 921
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
R G + D +L + D Y CEA N G+ + L V AP
Sbjct: 922 PRPGVHLSA-----DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWV-APVFPL 975
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP---PGSRHSIRADGSLHLDRA 828
+ T+ V EG P SL C G P P+ W KDG+PLP G +H L+L +A
Sbjct: 976 RESHTLTVREGHPTSLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 1034
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHITNEGVPASLPCVASG 884
G Y+C +N G+ +D++L V VPP+I P + +GV A+L C A+G
Sbjct: 1035 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATG 1093
Query: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
P PT+TW ++ + + ++ +L + + A G Y C A N G + ++ L
Sbjct: 1094 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1153
Query: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY 1004
SV P + + N+ TA +TL CEA G PPP + W + PV P + Y
Sbjct: 1154 SVLVPPELIGDLDPLTNI----TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1209
Query: 1005 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
L L++ Q Q DSG Y C ASN AG A + + V
Sbjct: 1210 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Score = 244 bits (622), Expect = 5e-64
Identities = 213/756 (28%), Positives = 306/756 (40%), Gaps = 62/756 (8%)
Query: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 408
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 1298 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1356
Query: 409 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
VTV+ L C L N+TW++D AS L+I D
Sbjct: 1357 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1416
Query: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS-QGVEVKVS------CSASGYP 518
G+Y CV +N G + + V P +S + V+ KV+ C + P
Sbjct: 1417 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 1476
Query: 519 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 1477 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536
Query: 578 TDPPSVSAVN----AVVLVAVGEEA----------------VLVCEASGVPPPRVIWYRG 617
PP V A +++ EEA L C+ + +PPP + WYR
Sbjct: 1537 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 1596
Query: 618 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT-- 672
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V P +
Sbjct: 1597 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGD 1656
Query: 673 --ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
EL +VTV + L C A G P PT++W + GL + + D VL
Sbjct: 1657 TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN-----GLPFSPSPRLQVLE-DGQVL 1710
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS-SAPTVRVLEGQPVSLPC 789
+ D A Y+C A N G AE + PP+IA V + VSLPC
Sbjct: 1711 QVSTAEVADAASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 1768
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V A P PE W KD + L G + +L L RA +G Y+C A N AG
Sbjct: 1769 DVHA-HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQ 1827
Query: 849 RDVELVVQVPP--RIHPTATHH--ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
+ V+L V VPP R P + G A L C +P PT+TW K+ L
Sbjct: 1828 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1887
Query: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ L I + D G Y C +N G + + L+V P +
Sbjct: 1888 TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----- 1942
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
V+ AG + L C+ G P P VTW KD PV + G L+L+++Q +G
Sbjct: 1943 -VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 2001
Query: 1025 YECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHH 1060
Y C A N A +V+ V + + HH
Sbjct: 2002 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 2037
Score = 242 bits (617), Expect = 2e-63
Identities = 235/835 (28%), Positives = 339/835 (40%), Gaps = 116/835 (13%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHFQES----GNSSWEILRASKAEEGTYECTAVSRAG 386
C H ++ R+G + E H Q S + S A+ G YEC A + G
Sbjct: 24 CGTHGTPKPQVTWRKGPS--SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
Query: 387 TGRAKAQIVVTDPPP--QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 444
+ +A++VV PP + NV+ G++ L C G + W++D +++
Sbjct: 82 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141
Query: 445 GRVAQLADL---------------SLEISGIIPTDGGRYQCVASNANGVTRASVW----- 484
G DL SL I P GR + + + T+A W
Sbjct: 142 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGR-RGAQAGGSAQTKAP-WXAGLA 199
Query: 485 ----------LLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQ-AL 531
P V ++Q G +V++ C SG PTP + W+++ Q L
Sbjct: 200 GFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL 259
Query: 532 QEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV 590
+ V G ++ I G D G Y C A + G L PP++ N
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETG 319
Query: 591 LVAVGEEAV--LVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGT 645
VAV E+ + L+CEA GVP P + W++ G + + + +L++ AQ DAG
Sbjct: 320 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 379
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPPTVTW 702
YTC+A N +G A +L V P + P V GR L C A G P PT++W
Sbjct: 380 YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 439
Query: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
+G P+ A + D VL ES Y C A + G +A + V
Sbjct: 440 HH-EGLPV-----AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG--EAVLQYSV 491
Query: 763 TGHAPPQ--IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
PPQ +A V + GQP+ LPC +G P+P WL++GRP + + +
Sbjct: 492 EVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGSPVPTIQWLQNGRPAEELAGVQVASQ 550
Query: 821 G-SLHLDRALQEHAGRYSCVATNTAGSQHRDVEL---------VVQVP-PRIHPTATHHI 869
G +LH+D +H+G ++C ATN AG+ +VE+ V++VP + H HH
Sbjct: 551 GTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH- 609
Query: 870 TNEGVPASL-------------PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 916
PA+ P + G +P W + T G S L I
Sbjct: 610 --SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT------GIPVAYSLPPPLQI 661
Query: 917 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTL 976
+ +D G Y C ATN G S +E+ L V P I P+ VTL
Sbjct: 662 EKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG-------PVNKAVLENASVTL 714
Query: 977 DCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
+C A G PPP V+W K +PV + LR+ Q Q+ D+G Y C ASN AGS
Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774
Query: 1037 SHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLP 1091
RY L V VP L P+L TP VRL + AP P
Sbjct: 775 ELRYGLRVN-----------VPPRITLPPSLPGPVLVNTP--VRLTCNATGAPSP 816
Score = 237 bits (605), Expect = 4e-62
Identities = 224/758 (29%), Positives = 310/758 (40%), Gaps = 61/758 (8%)
Query: 313 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 363
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 1742 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 1801
Query: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 419
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1861
Query: 420 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 1862 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 1921
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 537
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 1922 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 1979
Query: 538 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 593
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 1980 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 2039
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 648
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 2040 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL----GRSALLACRATGRPPPTVTWRR 704
A N G+ A + P + D + L G + C G PP V+W +
Sbjct: 2100 VAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK 2158
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG PL L R+ SG L V D + C A + G A+ +
Sbjct: 2159 -DGLPLPL------SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ 2209
Query: 764 GHAPPQI--ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP + V V+ G V LPC G PLP W+KDG PL S+
Sbjct: 2210 VQVPPVLEPVEFQNDVVVVRGSLVELPC-EARGVPLPLVSWMKDGEPL---LSQSLEQGP 2265
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA--THHITNEGVPASLP 879
SL L+ +G YSCVA + AG R +L V PP I + T G P L
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELL 2325
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
C A G P P ITW K+ ALT N S+ +L +DAG Y C A + G
Sbjct: 2326 CDAQGTPQPNITWHKDGQALTRL---ENNSRATRVL----RVRDAGLYTCLAESPAGAIE 2378
Query: 940 QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
+ R+ V P I G R P V A ++ L+C + P P +TW +D +
Sbjct: 2379 KSFRVRVQAPPNI--VGPRG---PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQE 2433
Query: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
+ L+L + DSG Y CTA N AGS S
Sbjct: 2434 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2471
Score = 188 bits (477), Expect = 3e-47
Identities = 162/493 (32%), Positives = 217/493 (44%), Gaps = 48/493 (9%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRG-GLEMILAPEGSS---SGKLRIPAAQERDAGT 645
V + VG EA C G P P+V W +G E + G + G L + + D+G
Sbjct: 13 VALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 71
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVE--LGRSALLACRATGRPPPTVTWR 703
Y C+A NE+G S +L V P + E R V G+S L C A G P P + W
Sbjct: 72 YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131
Query: 704 RGD---GQPLGLR-----LGAGRGSRSRQPDSG-VLFFESVAP--------------EDQ 740
+ G PLG LG G+ R D G L F + P + +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 741 APYVCEARNVFGKVQAEARLIVTGHAPPQI--ASSAPTVRVLEGQPVSLPCIVLAGRPLP 798
AP+ + G Q + APP + A +A V L G V L C +G P P
Sbjct: 192 APWXA---GLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWT-SGVPTP 247
Query: 799 ERHWLKDGRPLPPGSRH-SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856
+ W KD +P+ PG H ++ DG L + + GRY CVA + AG Q RD +L V
Sbjct: 248 QVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH 307
Query: 857 VPPRI---HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT 913
PP I + T + + + L C A GVP P ITW K+ L +
Sbjct: 308 APPTIWGSNETGEVAVMEDHL-VQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 366
Query: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEE 973
L + + + DAG Y C A+N VG + + RL V P I G R P V A AG
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR----PYVVKAVAGRP 422
Query: 974 VTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASNP 1032
V L+C A+G P P ++W + PV +N L GS LRL SG Y C AS+P
Sbjct: 423 VALECVARGHPSPTLSWHHEGLPVAE-SNESRLETDGSVLRLESPGEASSGLYSCVASSP 481
Query: 1033 AGSASHRYVLGVQ 1045
AG A +Y + VQ
Sbjct: 482 AGEAVLQYSVEVQ 494
Score = 141 bits (355), Expect = 4e-33
Identities = 120/395 (30%), Positives = 164/395 (41%), Gaps = 50/395 (12%)
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRG-DGQPLGLRLGAGRGSRSRQPDSGVLFFESV 735
DV + +G A C G P P VTWR+G +PL + G + G LF SV
Sbjct: 12 DVALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVA------VLEEGSLFLASV 64
Query: 736 APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV--LEGQPVSLPCIVLA 793
+P D Y C+A N G A+L+V + PP I V + GQ ++L C
Sbjct: 65 SPADSGDYECQATNEVGSTSRRAKLVV--YVPPSIREDGRKANVSGMAGQSLTLECDA-N 121
Query: 794 GRPLPERHWLKD----GRPL------------PPGSRHSIRADGSLHLDRALQEHAGRYS 837
G P+PE WLKD G PL G + SLH R +GR
Sbjct: 122 GFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRG 181
Query: 838 CVATNTAGSQ---HRDVELVVQVP------PRIHPT------ATHHITNEGVPASLPCVA 882
A +A ++ + Q P P P+ A + G L C
Sbjct: 182 AQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWT 241
Query: 883 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQE 941
SGVP P + WTK+ + GPH V ++G +L I D G Y C A + G +++
Sbjct: 242 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 301
Query: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
+L V+ P I +N +V V L CEA+G P P +TW KD +P T
Sbjct: 302 FQLRVHAPPTIW-----GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 356
Query: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
L+L + Q D+G Y C ASN G+A
Sbjct: 357 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA 391
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 324 bits (830), Expect = 4e-88
Identities = 236/724 (32%), Positives = 331/724 (45%), Gaps = 49/724 (6%)
Query: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 2153 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2208
Query: 397 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 454
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 2209 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 2261
Query: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 511
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 2262 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 2320
Query: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 570
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 2321 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2380
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI-------L 623
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 2381 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2440
Query: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
PEGS LRI +DAG Y C A N G L V P + P ++T+
Sbjct: 2441 LPEGS----LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
ALL C A+G P P V W + DGQ L RL G R S L + P+D A +
Sbjct: 2497 TPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGA---YRLLPSNALLLTAPGPQDSAQF 2552
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
C N G +A VT H PP IA V PV L C G P P W
Sbjct: 2553 ECVVSNEVG--EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWS 2609
Query: 804 KDGRPLPP-GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH 862
K G L GS + + G+L + +AL HAGRY+C A N+AG H+ V L VQ P +
Sbjct: 2610 KAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVK 2669
Query: 863 P--TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
P + + E V LPC ASG+P PTITW KE + G V G L IA S
Sbjct: 2670 PLPSVVRAVAEEEV--LLPCEASGIPRPTITWQKE-GLNVATGVSTQVLPGGQLRIAHAS 2726
Query: 921 AQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
+DAG Y+C A N+ G + + RL V P I NG + ++ G L C+A
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIE-NGLPD------LSTTEGSHAFLPCKA 2779
Query: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1040
+GSP P +TW KD +PV ++ + PSG L + ++ D+G Y CTA N G A R
Sbjct: 2780 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRV 2839
Query: 1041 VLGV 1044
L +
Sbjct: 2840 HLTI 2843
Score = 315 bits (806), Expect = 2e-85
Identities = 218/687 (31%), Positives = 316/687 (45%), Gaps = 32/687 (4%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTV--SPG 414
E+ + + +LR A G Y C A S AG ++ V PP + P P V +PG
Sbjct: 2258 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2315
Query: 415 ETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
+ VL C V E +TW RD VL L++ + D G Y C A N
Sbjct: 2316 QL-VLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2374
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
A G T + + + P + + + S + C A G P P +SW ++ L
Sbjct: 2375 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2434
Query: 535 S-RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
S R + +G+L IQ V +DAG+Y C A+N G+D++ L +PP+++ + + +
Sbjct: 2435 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLT 2494
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIPAAQERDAGTYTC 648
A+L CEASG P P V+W++ G ++ + + S L + A +D+ + C
Sbjct: 2495 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 2554
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
NE+G+A Q+ V P + + D TV + +L C +TG P PTV+W +
Sbjct: 2555 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA--- 2611
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
G +LGA RGS R SG L P Y C ARN G A + +T A P
Sbjct: 2612 --GAQLGA-RGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV--AHKHVFLTVQASP 2666
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA 828
+ VR + + V LPC +G P P W K+G + G + G L + A
Sbjct: 2667 VVKPLPSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHA 2725
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
E AG Y C+A N+AGS LVVQVPP I T EG A LPC A G P P
Sbjct: 2726 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP 2785
Query: 889 TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT 948
ITW K+ ++ + + G LL+ QDAG Y CTA N VG + + + L++
Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2845
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP-ITNRYGLL 1007
P +P + + G+ + L C A+GSP P + WT + RPV ++ + G
Sbjct: 2846 LPVF-------TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-- 2896
Query: 1008 PSGSLRLAQVQVGDSGHYECTASNPAG 1034
+L+ A V DSG Y C A N G
Sbjct: 2897 -GSTLQRAAVSREDSGTYVCWAENRVG 2922
Score = 288 bits (736), Expect = 3e-77
Identities = 225/785 (28%), Positives = 343/785 (43%), Gaps = 38/785 (4%)
Query: 317 PRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEER-HFQESGNSSWEILRASKAEEG 375
P ++ ++Q L+ C + R+ L F+ S I + G
Sbjct: 2398 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2457
Query: 376 TYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWV 434
Y C A + AG+ R + V +PP + P+P N+T++ A+L C G + W
Sbjct: 2458 HYLCLASNSAGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2516
Query: 435 RDWRVLP--ASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 492
+D + L G L +L ++ P D +++CV SN G + V P
Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576
Query: 493 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL-QEDSRIHVDAQGTLIIQGVA 551
++ + + V ++C ++G P P +SWS+ L S V G L I
Sbjct: 2577 IADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQAL 2636
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 611
P AG Y+C A N G + V L P V + +VV EE +L CEASG+P P
Sbjct: 2637 PIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT 2696
Query: 612 VIWYRGGLEMI--LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
+ W + GL + ++ + G+LRI A DAG Y C A N G A + +L V P
Sbjct: 2697 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP 2756
Query: 670 QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 729
+ D++ G A L C+A G P P +TW + DGQP+ G + QP SG
Sbjct: 2757 VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK-DGQPVS----GAEGKFTIQP-SGE 2810
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLP 788
L +++ +D Y C A N G+ + L + + ++ P R L G + L
Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL---VLPVFTTLPGDRSLRLGDRLWLR 2867
Query: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL--QEHAGRYSCVATNTAGS 846
C G P P W + RP+ G DG L RA +E +G Y C A N G
Sbjct: 2868 CAA-RGSPTPRIGWTVNDRPVTEGVSEQ---DGGSTLQRAAVSREDSGTYVCWAENRVGR 2923
Query: 847 QHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ V+ P + A ++ G L CV G P P I W K+ L RG H
Sbjct: 2924 TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD--GLPLRGSH 2981
Query: 906 YNVS-KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ G+L I + DAG Y C A N +G + + + L + + P + P
Sbjct: 2982 LRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE-------PQ 3034
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
+T ++G++V L C+A G P P + W + +P+ + R LP GSL L V+ GD+G
Sbjct: 3035 DMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGT 3093
Query: 1025 YECTASNPAGSASHRYVLGVQG--RTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLC 1082
Y+C A N GSA+ R L V+G + SW + + ++ L+ ++Q V
Sbjct: 3094 YDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSI 3153
Query: 1083 HLSLR 1087
H S+R
Sbjct: 3154 HSSIR 3158
Score = 285 bits (729), Expect = 2e-76
Identities = 226/698 (32%), Positives = 312/698 (44%), Gaps = 52/698 (7%)
Query: 360 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAV 418
G EI A +++G Y C + AG + V PP P V+ G V
Sbjct: 1802 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV 1861
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
L+C V G +TW++D + +S L++S + P G Y CVA N
Sbjct: 1862 LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 1921
Query: 479 TRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS- 535
R + V AP++ S H +G EV++ C A G P P ++W ++ L +D
Sbjct: 1922 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 1981
Query: 536 ---RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS--AVNAVV 590
R ++D G+L+++G+ DAG Y+C A N G D T+ PP++ A +
Sbjct: 1982 PHLRFYLDG-GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 2040
Query: 591 LVA-VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTY 646
LV+ GE +VC G PP V W + GL + L+ G LRI Q DAG +
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF 2100
Query: 647 TCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
TC A + G A L V P L E DV V G L C A G P P V+W +
Sbjct: 2101 TCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK 2160
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSGV-LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG+PL S+ + G L E+V D Y C A + G+ + +L V
Sbjct: 2161 -DGEPL----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 2209
Query: 764 GHAPPQIASSA-PT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP I S PT + + G P+ L C G P P W KDG+ L R +
Sbjct: 2210 --EPPHIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALT-------RLEN 2259
Query: 822 SLHLDRALQ-EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL-- 878
+ R L+ AG Y+C+A + AG+ + + VQ PP I P L
Sbjct: 2260 NSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 2319
Query: 879 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQP-SAQDAGAYVCTATNTVGF 937
C PAP ITW ++ L H + G L Q S D+G Y CTA N G
Sbjct: 2320 ECSVEAEPAPKITWHRDGIVL-QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2378
Query: 938 SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
+S R+ ++T P I +G NV + TA L C+A G P PLV+W KD P+
Sbjct: 2379 TSVAFRVEIHTVPTIR-SGPPAVNVSVNQTA------LLPCQADGVPAPLVSWRKDRVPL 2431
Query: 998 PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
P + R+ +LP GSLR+ V D+GHY C ASN AGS
Sbjct: 2432 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2469
Score = 283 bits (725), Expect = 5e-76
Identities = 224/766 (29%), Positives = 335/766 (43%), Gaps = 46/766 (6%)
Query: 306 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 360
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 417
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 1992 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049
Query: 418 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 477
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2109
Query: 478 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 534
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 2110 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2168
Query: 535 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 592
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 2169 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 2225
Query: 593 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 2226 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 2281
Query: 653 ELGDASAEIQLAVGHAPQLT--ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 710
G ++ V P + PR V +L C P P +TW R DG L
Sbjct: 2282 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVL 2340
Query: 711 GLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
+ ++ P+ G L ++++ D Y C ARN G R+ + H P
Sbjct: 2341 Q------EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI--HTVPT 2392
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRA 828
I S P V V Q LPC G P P W KD PL P S R I +GSL +
Sbjct: 2393 IRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPV 2451
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
L + AG Y C+A+N+AGS + +L V PP I P+ ++ PA LPC ASG P P
Sbjct: 2452 LAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 2511
Query: 889 TITWTKETNALTSRGPH--YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+ W K+ L R Y + LL+ P QD+ + C +N VG + + +++V
Sbjct: 2512 LVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 2571
Query: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
+ P I A+ T V L C + G P P V+W+K + + Y +
Sbjct: 2572 HVPPTI-------ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2624
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
PSG+L + Q +G Y C+A N AG A L VQ +P
Sbjct: 2625 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKP 2670
Score = 276 bits (706), Expect = 9e-74
Identities = 231/778 (29%), Positives = 332/778 (42%), Gaps = 69/778 (8%)
Query: 311 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 365
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 695 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 754
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 425
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 814
Query: 426 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 815 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 874
Query: 486 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 542
V AP + S + +G ++SC G P P ISW ++ Q L + HV A
Sbjct: 875 NVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 934
Query: 543 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 598
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 994
Query: 599 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 995 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 1051
Query: 653 ELGDASAEIQLAVGHAPQLT---ELPRDVTVELGRSALLACRATGRPPPTVTWRRGD--- 706
G A + +L+V P+L + ++T L L C A G PPP + W RG+
Sbjct: 1052 LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPV 1111
Query: 707 --GQPLGLRLGAG--RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
G+ L G + +++++ DSG+ Y C A N G +A V
Sbjct: 1112 SPGEDTYLLAGGWMLKMTQTQEQDSGL-------------YSCLASNEAG--EARRNFSV 1156
Query: 763 TGHAPPQIASS--APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
PP I + ++VL+GQ L C V G P P+ W KDGRPL G H I D
Sbjct: 1157 EVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKLTWFKDGRPLARGDAHHISPD 1215
Query: 821 GSL-HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHIT-NEGV 874
G L + +A AG YSC+A N G + + +L V + P I +A +T
Sbjct: 1216 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1275
Query: 875 PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-------IAQPSAQDAGAY 927
P SL C A P+P ITW K+ G + S+ LL I +DAG Y
Sbjct: 1276 PISLICEALAFPSPNITWMKD-------GAPFEASRNIQLLPGTHGLQILNAQKEDAGQY 1328
Query: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
C TN +G + + + V P I + +V K +TL+CE+ PPP
Sbjct: 1329 TCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPT 1388
Query: 988 VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ W KD +PV P + L L++ QV DSG Y C A+N AG + + +Q
Sbjct: 1389 IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1446
Score = 270 bits (689), Expect = 8e-72
Identities = 234/784 (29%), Positives = 326/784 (41%), Gaps = 89/784 (11%)
Query: 323 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 378
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 1084 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 1140
Query: 379 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 434
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 1198
Query: 435 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 494
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 1199 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 1257
Query: 495 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 546
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 1258 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 1316
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGE------- 596
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V E
Sbjct: 1317 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS 1373
Query: 597 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 653
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 1374 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1433
Query: 654 LGDASAEIQLAVGHAPQLTE----------LPRDVTVELG----------RSALLACRAT 693
G+ + + + P + L R+ G A L C
Sbjct: 1434 AGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN 1493
Query: 694 GRPPPTVTWRRGDGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
PPP +TW R D QPL G + +G R VL V E+ Y C+A N
Sbjct: 1494 AIPPPDLTWYRED-QPLSAGDEVSVLQGGR-------VLQIPLVRAENAGRYSCKASNEV 1545
Query: 752 GKVQAEARLIVTGHAPPQIASSAPT----VRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
G+ L+V PP I V V VSL C L G P+P WL++G
Sbjct: 1546 GEDWLHYELLVL--TPPVILGDTEELVEEVTVNASSTVSLQCPAL-GNPVPTISWLQNGL 1602
Query: 808 PLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTAT 866
P P R + DG L + A A Y CVA N AGS + L VQVPPRI
Sbjct: 1603 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 1662
Query: 867 HHIT---NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 923
+T N V SLPC P P +TW K++ AL+ + + TL + + D
Sbjct: 1663 EQVTAILNSSV--SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSD 1720
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHM--NGSRNANVPLQVTAKAGEEVTLDCEAK 981
+G Y C A N G + ++LSV P G ++A V + G++ L CE
Sbjct: 1721 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDA-----VLVRVGDKAVLSCETD 1775
Query: 982 GSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
P P VTW KD +P+ L L + + QV D G Y C SN AG A +
Sbjct: 1776 ALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1835
Query: 1042 LGVQ 1045
L VQ
Sbjct: 1836 LTVQ 1839
Score = 268 bits (686), Expect = 2e-71
Identities = 249/863 (28%), Positives = 360/863 (41%), Gaps = 90/863 (10%)
Query: 351 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 407
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 171 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 224
Query: 408 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 460
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 225 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 281
Query: 461 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE---VKVSCSASGY 517
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 282 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 341
Query: 518 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 342 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 401
Query: 577 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGK 632
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 461
Query: 633 -LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH--APQLTELPRDVTVELGRSALLA 689
L I + +G + C+A NE G A AE++++V AP + E+P G +
Sbjct: 462 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIG-QYHWGXEHHSS 520
Query: 690 CRATGRPPPTVTWRRGDGQPL-------GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
A PP W PL G G G L E V D+
Sbjct: 521 FPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGI 580
Query: 743 YVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
Y C A N+ G+ + E L V PP I VLE V+L C+ +G P P+ W
Sbjct: 581 YTCAATNLAGESKREVALKVL--VPPNIEPGPVNKAVLENASVTLECLA-SGVPPPDVSW 637
Query: 803 LKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861
K +P+ ++ DG L +++A AG Y CVA+N AGS L V VPPRI
Sbjct: 638 FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRI 697
Query: 862 H-PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG-PHYNVSKEGTLL-IAQ 918
P + P L C A+G P+PT+ W K+ N ++ G P V G +L +A
Sbjct: 698 TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLAS 757
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC 978
A D+G Y C A + VG Q++ L V+ P I L V+ A E V L+C
Sbjct: 758 ARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI-------LGEELNVSVVANESVALEC 810
Query: 979 EAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1038
++ PPP+++W KD RP+ P + L++ + V D+GHY C A N AG +
Sbjct: 811 QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK 870
Query: 1039 RYVLGVQGRTSWQPQSLPVPH---------HPACLS----GLSVPLL------QPTP-RS 1078
Y L V W P+ HP LS G+ P + QP P
Sbjct: 871 HYNLNV-----WVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG 925
Query: 1079 VRLCHLSL--------RAPLPPPFATPTSCLSQACLSSSTLSLHLS-PYPLRGPGDAVQR 1129
L H+S +A L C + SS L L + P + GP +
Sbjct: 926 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP----RE 981
Query: 1130 PPTTQGRAQWGPGFGRTGVRGEP 1152
PPT Q G G+P
Sbjct: 982 PPTQVSVVQDGVATLECNATGKP 1004
Score = 255 bits (652), Expect = 2e-67
Identities = 200/700 (28%), Positives = 308/700 (44%), Gaps = 45/700 (6%)
Query: 375 GTYECTAVSRAGTGRAKAQIVVTDP-PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTW 433
G + C A + AGT A+ ++ V P ++ P G S + P + W
Sbjct: 474 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 533
Query: 434 --------VRDWRVLPASTGR-----VAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
V W + G VA L+I + D G Y C A+N G ++
Sbjct: 534 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 593
Query: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
V L V P + ++ + V + C ASG P P +SW + Q + + V
Sbjct: 594 REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVS 653
Query: 541 AQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV-LVAVGEEA 598
G ++ I+ DAG+Y C A+N G+ + L PP ++ ++ V V
Sbjct: 654 VDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPV 713
Query: 599 VLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-------LRIPAAQERDAGTYTCRAV 651
L C A+G P P ++W + G + +P G+ + L + +A+ D+G Y+C AV
Sbjct: 714 RLTCNATGAPSPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 771
Query: 652 NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG 711
+ +G+ ++ L V P + +V+V S L C++ PPP ++W + DG+PL
Sbjct: 772 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLE 830
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
R G + D +L + D Y CEA N G + L V AP
Sbjct: 831 PRPGVHLSA-----DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV-APVFPL 884
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP---PGSRHSIRADGSLHLDRA 828
+ T+ V EG P L C G P P+ W KDG+PLP G +H L+L +A
Sbjct: 885 RESHTLTVREGHPTRLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 943
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI----HPTATHHITNEGVPASLPCVASG 884
G Y+C +N G+ +D++L V VPP+I P + +GV A+L C A+G
Sbjct: 944 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATG 1002
Query: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
P PT+TW ++ + + ++ +L + + A G Y C A N G + ++ L
Sbjct: 1003 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1062
Query: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY 1004
SV P + + N+ TA +TL CEA G PPP + W + PV P + Y
Sbjct: 1063 SVLVPPELIGDLDPLTNI----TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1118
Query: 1005 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
L L++ Q Q DSG Y C ASN AG A + + V
Sbjct: 1119 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Score = 250 bits (638), Expect = 7e-66
Identities = 216/732 (29%), Positives = 303/732 (41%), Gaps = 52/732 (7%)
Query: 346 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-- 403
G ++G R E S R + + G Y C A ++AGT + ++V PP L
Sbjct: 73 GWGQVGGHRLLDEG--QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130
Query: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIP 462
A V G L C G + W +D + VLP Q L I+G
Sbjct: 131 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 190
Query: 463 TDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTP 520
D GRYQCVA + G L V P + S T + V++ C A G PTP
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 250
Query: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNEVGTDQETVTLYYTD 579
+I+W ++ L +++ G + G A DAG Y+C+A+N VG ++ L
Sbjct: 251 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 310
Query: 580 PPSVSAVNA---VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKL 633
PP++ VV G L C A G P P + W+ GL + + E + L
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 370
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACR 691
R+ + E +G Y+C A + G+A + + V PQL E VT +G+ L C+
Sbjct: 371 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQ 430
Query: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
A+G P PT+ W + +G+P G S+ L + V + + C+A N
Sbjct: 431 ASGSPVPTIQWLQ-NGRPAEELAGVQVASQGT-----TLHIDHVELDHSGLFACQATNEA 484
Query: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEG--QPVSLPCIVLAGRPLPERHWLKDGRP- 808
G AE + V G P + P + G S P A P R W +P
Sbjct: 485 GTAGAEVEVSVHGEWAPGVL-EVPIGQYHWGXEHHSSFPA---ACDPPVHRGWGAHPKPP 540
Query: 809 -------------LPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV 855
P G + L +++ G Y+C ATN AG R+V L V
Sbjct: 541 LVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 600
Query: 856 QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL 915
VPP I P + E +L C+ASGVP P ++W K ++S VS +G +L
Sbjct: 601 LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS-WMGVTVSVDGRVL 659
Query: 916 -IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
I Q DAG+Y C A+N G + L VN PRI + S L V
Sbjct: 660 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPS------LPGPVLVNTPV 713
Query: 975 TLDCEAKGSPPPLVTWTKDSRPVPPI-TNRYGLLPSGS-LRLAQVQVGDSGHYECTASNP 1032
L C A G+P P + W KD PV P T + P G L LA + DSG Y C A +
Sbjct: 714 RLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 773
Query: 1033 AGSASHRYVLGV 1044
G VL V
Sbjct: 774 VGEDRQDVVLQV 785
Score = 249 bits (635), Expect = 1e-65
Identities = 218/737 (29%), Positives = 307/737 (41%), Gaps = 91/737 (12%)
Query: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL-------------- 453
NV+ G++ L C G + W++D +++ G DL
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 454 -SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKV 510
SL I D G Y C A N G + LLV P V ++Q G +V++
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 146
Query: 511 SCSASGYPTPHISWSRESQ-ALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGT 568
C SG PTP + W+++ Q L + V G ++ I G D G Y C A + G
Sbjct: 147 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 569 DQETVTLYYTDPPSVSAVNAVVLVAVGEEAV--LVCEASGVPPPRVIWYRGGLEMILAPE 626
L PP++ N VAV E+ + L+CEA GVP P + W++ G + + +
Sbjct: 207 QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK 266
Query: 627 ---GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTV 680
+L++ AQ DAG YTC+A N +G A +L V P + P V
Sbjct: 267 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKA 326
Query: 681 ELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 740
GR L C A G P PT++W +G P+ A + D VL ES
Sbjct: 327 VAGRPVALECVARGHPSPTLSWHH-EGLPV-----AESNESRLETDGSVLRLESPGEASS 380
Query: 741 APYVCEARNVFGKVQAEARLIVTGHAPPQ--IASSAPTVRVLEGQPVSLPCIVLAGRPLP 798
Y C A + G +A + V PPQ +A V + GQP+ LPC +G P+P
Sbjct: 381 GLYSCVASSPAG--EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGSPVP 437
Query: 799 ERHWLKDGRPLPPGSRHSIRADG-SLHLDRALQEHAGRYSCVATNTAGSQHRDVEL---- 853
WL++GRP + + + G +LH+D +H+G ++C ATN AG+ +VE+
Sbjct: 438 TIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 497
Query: 854 -----VVQVP-PRIHPTATHHITNEGVPASL-------------PCVASGVPAPTITWTK 894
V++VP + H HH PA+ P + G +P W +
Sbjct: 498 EWAPGVLEVPIGQYHWGXEHH---SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 554
Query: 895 ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHM 954
T G S L I + +D G Y C ATN G S +E+ L V P I
Sbjct: 555 PT------GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 608
Query: 955 NGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRL 1014
P+ VTL+C A G PPP V+W K +PV + LR+
Sbjct: 609 G-------PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 661
Query: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQP 1074
Q Q+ D+G Y C ASN AGS RY L V VP L P+L
Sbjct: 662 EQAQLSDAGSYRCVASNVAGSTELRYGLRVN-----------VPPRITLPPSLPGPVLVN 710
Query: 1075 TPRSVRLCHLSLRAPLP 1091
TP VRL + AP P
Sbjct: 711 TP--VRLTCNATGAPSP 725
Score = 245 bits (625), Expect = 2e-64
Identities = 211/756 (27%), Positives = 305/756 (40%), Gaps = 62/756 (8%)
Query: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 408
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 1207 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1265
Query: 409 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
VTV+ L C L N+TW++D AS L+I D
Sbjct: 1266 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1325
Query: 466 GRYQCVASNANG--VTRASVWLLV-----REAPQVSIHTSSQHFSQGVEVKVSCSASGYP 518
G+Y CV +N G V V +L+ ++ P + + + C + P
Sbjct: 1326 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVP 1385
Query: 519 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 1386 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445
Query: 578 TDPPSVSAVN----AVVLVAVGEEA----------------VLVCEASGVPPPRVIWYRG 617
PP V A +++ EEA L C+ + +PPP + WYR
Sbjct: 1446 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 1505
Query: 618 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT-- 672
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V P +
Sbjct: 1506 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGD 1565
Query: 673 --ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
EL +VTV + L C A G P PT++W + GL + + D VL
Sbjct: 1566 TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN-----GLPFSPSPRLQVLE-DGQVL 1619
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS-SAPTVRVLEGQPVSLPC 789
+ D A Y+C A N G AE + PP+IA V + VSLPC
Sbjct: 1620 QVSTAEVADAASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 1677
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V A P PE W KD + L G + +L L RA +G Y+C A N AG
Sbjct: 1678 DVHA-HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQ 1736
Query: 849 RDVELVVQVPP--RIHPTATHH--ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
+ V+L V VPP R P + G A L C +P PT+TW K+ L
Sbjct: 1737 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1796
Query: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ L I + D G Y C +N G + + L+V P +
Sbjct: 1797 TQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----- 1851
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
V+ AG + L C+ G P P VTW KD PV + G L+L+++Q +G
Sbjct: 1852 -VSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 1910
Query: 1025 YECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHH 1060
Y C A N A +V+ V + + HH
Sbjct: 1911 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 1946
Score = 237 bits (605), Expect = 4e-62
Identities = 224/758 (29%), Positives = 310/758 (40%), Gaps = 61/758 (8%)
Query: 313 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 363
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 1651 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 1710
Query: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 419
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1770
Query: 420 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 1771 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 1830
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 537
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 1831 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 1888
Query: 538 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 593
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 1889 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 1948
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 648
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 1949 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL----GRSALLACRATGRPPPTVTWRR 704
A N G+ A + P + D + L G + C G PP V+W +
Sbjct: 2009 VAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK 2067
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DG PL L R+ SG L V D + C A + G A+ +
Sbjct: 2068 -DGLPLPL------SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG--VADRNFTLQ 2118
Query: 764 GHAPPQI--ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
PP + V V+ G V LPC G PLP W+KDG PL S+
Sbjct: 2119 VQVPPVLEPVEFQNDVVVVRGSLVELPC-EARGVPLPLVSWMKDGEPL---LSQSLEQGP 2174
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA--THHITNEGVPASLP 879
SL L+ +G YSCVA + AG R +L V PP I + T G P L
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELL 2234
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
C A G P P ITW K+ ALT N S+ +L +DAG Y C A + G
Sbjct: 2235 CDAQGTPQPNITWHKDGQALTRL---ENNSRATRVL----RVRDAGLYTCLAESPAGAIE 2287
Query: 940 QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
+ R+ V P I G R P V A ++ L+C + P P +TW +D +
Sbjct: 2288 KSFRVRVQAPPNI--VGPRG---PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQE 2342
Query: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
+ L+L + DSG Y CTA N AGS S
Sbjct: 2343 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2380
Score = 182 bits (463), Expect = 1e-45
Identities = 148/508 (29%), Positives = 212/508 (41%), Gaps = 45/508 (8%)
Query: 580 PPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---------- 627
PPS+ A V G+ L C+A+G P P ++W + +++ P G
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA-QLVGVPLGWAGYGWDLGW 74
Query: 628 ---------SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPR 676
L P QE D+G Y+CRA N+ G A + L V P + +
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
+V G L C +G P P V W + D QP + G Q D VL
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTK-DRQP----VLPGGPHLQVQEDGQVLRITGSH 189
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT--VRVLEGQPVSLPCIVLAG 794
D+ Y C A + G+ + +L V HAPP I S T V V+E V L C G
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDFQLRV--HAPPTIWGSNETGEVAVMEDHLVQLLC-EARG 246
Query: 795 RPLPERHWLKDGRPLPPGSRHSIRADG-SLHLDRALQEHAGRYSCVATNTAGSQHRDVEL 853
P P W KDG LP ++ G L L RA AG Y+C A+N G+ + L
Sbjct: 247 VPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRL 306
Query: 854 VVQVPPRIHPTATHHITNEGV---PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSK 910
V VPP I + V P +L CVA G P+PT++W E + +
Sbjct: 307 DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETD 366
Query: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
L + P +G Y C A++ G + + + V P++ + A QVT
Sbjct: 367 GSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLV-----AEGLGQVTTIV 421
Query: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTAS 1030
G+ + L C+A GSP P + W ++ RP + +L + V++ SG + C A+
Sbjct: 422 GQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQAT 481
Query: 1031 NPAGSASHRYVLGVQGRTSWQPQSLPVP 1058
N AG+A + V G W P L VP
Sbjct: 482 NEAGTAGAEVEVSVHG--EWAPGVLEVP 507
Score = 132 bits (333), Expect = 2e-30
Identities = 98/299 (32%), Positives = 131/299 (43%), Gaps = 28/299 (9%)
Query: 760 LIVTGHA-PPQIASSAPTVRV--LEGQPVSLPCIVLAGRPLPERHWLKD----GRPL--- 809
L+ TG PP I V + GQ ++L C G P+PE WLKD G PL
Sbjct: 8 LLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVPLGWA 66
Query: 810 ---------PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 860
G + SLH R + +G YSC A N AG+ RD L+V PP
Sbjct: 67 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 126
Query: 861 I--HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IA 917
+ A + G L C SGVP P + WTK+ + GPH V ++G +L I
Sbjct: 127 VLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT 186
Query: 918 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977
D G Y C A + G +++ +L V+ P I +N +V V L
Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW-----GSNETGEVAVMEDHLVQLL 241
Query: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
CEA+G P P +TW KD +P T L+L + Q D+G Y C ASN G+A
Sbjct: 242 CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA 300
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 267 bits (682), Expect = 5e-71
Identities = 226/709 (31%), Positives = 306/709 (43%), Gaps = 86/709 (12%)
Query: 370 SKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ-----------LVPAPNVTVSPGETAV 418
S A+ G Y C A S G + +A VT PP + + P+ TV G+ A
Sbjct: 2982 SPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDAS 3040
Query: 419 LSCRVL-GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 477
C + G AP +L W + L + ++ + + I G P++ G Y+CVASNA G
Sbjct: 3041 FKCLIHDGAAPISLEWKTRNQELEDNV-HISPNGSI-ITIVGTRPSNHGTYRCVASNAYG 3098
Query: 478 VTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQA---LQE 533
V ++ V L V P VS+ + + G V + C ++G P W+R S L++
Sbjct: 3099 VAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
Query: 534 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVN 587
+ +D+ L I P DAG Y C A N +GT Q+ V + P V A
Sbjct: 3159 RTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE 3218
Query: 588 AVVLVAVGEEAVLVCEASGVPPPRVIW--YRGGLEMILAPEGSSSGKLRIPAAQERDAGT 645
A + V G A L C A+G P P + W R L EG + L IP ++D+G
Sbjct: 3219 AELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT---LIIPRVAQQDSGQ 3275
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRR- 704
Y C A + G A A I L V P T +P +V+ G + L C A G PP T W R
Sbjct: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRV 3335
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 764
G P GR + + +L FE APED Y C N G +A A+L+V G
Sbjct: 3336 GSSLP-------GRATARNE----LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQG 3384
Query: 765 HAPPQI-------ASSAPTVRVLE-------GQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
PP A S PTV+V G V C V + R R W K+G LP
Sbjct: 3385 --PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR-WFKEGGQLP 3441
Query: 811 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR--IHPTATHH 868
PG HS++ DG L + Q G Y C A G +LV+Q P I+ +
Sbjct: 3442 PG--HSVQ-DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ 3498
Query: 869 ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN---VSKEGTLLIAQPSAQDAG 925
G C+A G P P +TW+K G H V G + IA DAG
Sbjct: 3499 TVVVGHAVEFECLALGDPKPQVTWSKV-------GGHLRPGIVQSGGVVRIAHVELADAG 3551
Query: 926 AYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP 985
Y CTATN G + + L V P+I M P +V AG C A G P
Sbjct: 3552 QYRCTATNAAGTTQSHVLLLVQALPQISM--------PQEVRVPAGSAAVFPCIASGYPT 3603
Query: 986 PLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
P ++W+K +PP + L + L L V+ D+G Y CTA+N G
Sbjct: 3604 PDISWSKLDGSLPPDSR----LENNMLMLPSVRPQDAGTYVCTATNRQG 3648
Score = 258 bits (660), Expect = 2e-68
Identities = 219/760 (28%), Positives = 318/760 (41%), Gaps = 94/760 (12%)
Query: 368 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT-----------VSPGET 416
+ S A+ G Y C +GT A + + P +PAP + V+ G+T
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
Query: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 476
L+C V G+A +TW + LPA Q L + + P D G Y C A++
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSLPARH----QTHGSQLRLHLVSPADSGEYVCRAASGP 2997
Query: 477 GVTRASVWLLV----------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP-HISWS 525
G + + + + +P +SI S QG + C P + W
Sbjct: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
Query: 526 RESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 584
+Q L+++ +H+ G++I I G P + G Y C A+N G Q V L PP+VS
Sbjct: 3058 TRNQELEDN--VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
Query: 585 AV-NAVVLVAVGEEAVLVCEASGVPPPRVIWYR-----GGLEMILAPEGSSSGKLRIPAA 638
+ V V VG+ L C ++G P W R LE S L+I +A
Sbjct: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSA 3175
Query: 639 QERDAGTYTCRAVNELGDASAEIQLAVGH------APQLTELPRDVTVELGRSALLACRA 692
+ DAGTY C A N LG A ++++ V APQ+ ++TVE G +A L C A
Sbjct: 3176 KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
Query: 693 TGRPPPTVTWRR-GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
TG P PT+ W + P RL + L VA +D Y+C A +
Sbjct: 3236 TGSPAPTIHWSKLRSPLPWQHRL-----------EGDTLIIPRVAQQDSGQYICNATSPA 3284
Query: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 811
G AEA +I+ +PP + V G+ V L C+ PL + W + G LP
Sbjct: 3285 G--HAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ-WSRVGSSLP- 3340
Query: 812 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP-------- 863
R + R + LH +RA E +GRY C TN GS +L+VQ PP P
Sbjct: 3341 -GRATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGS 3398
Query: 864 TATHHITNE------GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 917
T T +T + G C + W KE L P ++V ++G L I
Sbjct: 3399 TPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP---PGHSV-QDGVLRIQ 3454
Query: 918 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977
G Y+C A G + +L + P + +N + T G V +
Sbjct: 3455 NLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ-----TVVVGHAVEFE 3509
Query: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSL-RLAQVQVGDSGHYECTASNPAGSA 1036
C A G P P VTW+K + P G++ SG + R+A V++ D+G Y CTA+N AG+
Sbjct: 3510 CLALGDPKPQVTWSKVGGHLRP-----GIVQSGGVVRIAHVELADAGQYRCTATNAAGTT 3564
Query: 1037 SHRYVLGVQGRTS-WQPQSLPVPH-----HPACLSGLSVP 1070
+L VQ PQ + VP P SG P
Sbjct: 3565 QSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTP 3604
Score = 243 bits (620), Expect = 8e-64
Identities = 199/679 (29%), Positives = 281/679 (41%), Gaps = 57/679 (8%)
Query: 287 GKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLH-QPLLVSCSVHS-ALPFRLQLR 344
G + E + + V S +P++S+ P Q C +H A P L+ +
Sbjct: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
Query: 345 RGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QL 403
L + H +G S I+ + GTY C A + G ++ + V PP +
Sbjct: 3058 TRNQELEDNVHISPNG-SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
Query: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGII 461
+P V V G+ L C GE + W R R L D L+IS
Sbjct: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176
Query: 462 PTDGGRYQCVASNANGVTRASVWLLVRE------APQVSIHTSSQHFSQGVEVKVSCSAS 515
P+D G Y C+A NA G + V ++V APQV + G + CSA+
Sbjct: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
Query: 516 GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL 575
G P P I WS+ L R+ D TLII VA +D+G Y C AT+ G + T+ L
Sbjct: 3237 GSPAPTIHWSKLRSPLPWQHRLEGD---TLIIPRVAQQDSGQYICNATSPAGHAEATIIL 3293
Query: 576 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK--- 632
+ PP + V V GE L C A G PP W R G + G ++ +
Sbjct: 3294 HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL----PGRATARNEL 3349
Query: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--------------GHAPQLTELPRDV 678
L A D+G Y CR N++G A A QL V G P + P+
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
T +G S C + W + GQ P G GVL +++
Sbjct: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG-----------HSVQDGVLRIQNLDQ 3458
Query: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Q Y+C+A +GK QA A+L++ I V+ G V C+ L G P
Sbjct: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL-GDPK 3517
Query: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 857
P+ W K G L PG +++ G + + AG+Y C ATN AG+ V L+VQ
Sbjct: 3518 PQVTWSKVGGHLRPG---IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA 3574
Query: 858 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 917
P+I + G A PC+ASG P P I+W+K +L P + + L++
Sbjct: 3575 LPQISMPQEVRVP-AGSAAVFPCIASGYPTPDISWSKLDGSL----PPDSRLENNMLMLP 3629
Query: 918 QPSAQDAGAYVCTATNTVG 936
QDAG YVCTATN G
Sbjct: 3630 SVRPQDAGTYVCTATNRQG 3648
Score = 212 bits (540), Expect = 2e-54
Identities = 206/742 (27%), Positives = 292/742 (39%), Gaps = 91/742 (12%)
Query: 375 GTYECTAVSRAGTGRAKAQI---VVTDPPPQ---LVPAPN-----VTVSPGETAV----- 418
G Y CTA TG+ Q V +P Q +P N V V P + V
Sbjct: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
Query: 419 --LSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475
L C+V G P+ W R D R +P+ T + Q ++L + P+D G Y C N
Sbjct: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL--HFPSVQPSDAGVYICTCRNL 1751
Query: 476 NGVTRASVWLLVREAPQVSIHTS-----SQHFSQGVEVKVSCSA-SGYPTPHISWSRESQ 529
+ + LLV EAP I + SQ G +V C+A S P + W+R
Sbjct: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
Query: 530 ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY-----TDPPSVS 584
+ D G L I+ V DAG Y C +N DQ T TL+ P VS
Sbjct: 1812 GKLPTRAM--DFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS 1869
Query: 585 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 644
+ V G+ A C A+G P P + W G + A G LR+PA + D
Sbjct: 1870 IHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQA 1929
Query: 645 TYTCRAVNELGDASAEIQLAV--GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 702
Y CRA + G A L V G P++ P V GR+ L CRA G P T+TW
Sbjct: 1930 QYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITW 1989
Query: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
R+ G +RS + D L ++ D Y+C A + G QA +++V
Sbjct: 1990 RKEGG-------SLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVV 2042
Query: 763 ---TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA 819
+ +PP + + + V EGQ + L C+V AG + W + G LPP H+
Sbjct: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVV-AGSAHAQVTWYRRGGSLPP---HTQVH 2098
Query: 820 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----------------QVPPRIHP 863
L L + +G Y C N +G + + + V P RI P
Sbjct: 2099 GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP 2158
Query: 864 TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQ 922
+++H EG L CV G +TW K +L +R G+LL + Q +
Sbjct: 2159 SSSH--VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH-----QTHGSLLRLHQVTPA 2211
Query: 923 DAGAYVCTATNTVGFSSQEMRLSVNTK------PRIHMNGSRNANVPLQVTAKAGEEVTL 976
D+G YVC T G + +++ P + + S + T G+ + L
Sbjct: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS-------TVAEGQTLDL 2264
Query: 977 DCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
C G VTW K +P G L + Q D+G Y C ASN ++
Sbjct: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQVRG----SRLYIFQASPADAGQYVCRASNGMEAS 2320
Query: 1037 SHRYVLGVQGRTSWQPQSLPVP 1058
V G QG P P
Sbjct: 2321 ITVTVTGTQGANLAYPAGSTQP 2342
Score = 209 bits (531), Expect = 2e-53
Identities = 210/747 (28%), Positives = 302/747 (40%), Gaps = 101/747 (13%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT-----DPPPQLVPAPNVTVSPGE 415
N I ++ GTY CT + + A + V P + P +TV PG+
Sbjct: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQ 1881
Query: 416 TAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
A C G L W LPA AQ+ L + + PTD +Y C A +
Sbjct: 1882 LAEFRCSATGSPTPTLEWTGGPGGQLPAK----AQIHGGILRLPAVEPTDQAQYLCRAHS 1937
Query: 475 ANG--VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 532
+ G V RA + + P+V + G V++ C A+G P+ I+W +E +L
Sbjct: 1938 SAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLP 1997
Query: 533 EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ---ETVTLYYTD--PPSVSAVN 587
+R TL+I + DAG Y C AT+ GT Q + V L +D PP V +
Sbjct: 1998 PQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES 2057
Query: 588 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG-KLRIPAAQERDAGTY 646
+ V G+ L C +G +V WYR G L P G +LR+P D+G Y
Sbjct: 2058 SSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS--LPPHTQVHGSRLRLPQVSPADSGEY 2115
Query: 647 TCRAVNELGDASAEIQLAVGH----APQLTELP---RDVTVE-------LGRSALLACRA 692
CR N G A I ++V H P T +P R + +E G++ L C
Sbjct: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV 2175
Query: 693 TGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
G+ VTW +RG P Q +L V P D YVC
Sbjct: 2176 PGQAHAQVTWHKRGGSLP-----------ARHQTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
Query: 752 GKVQAEARL-----IVTGHAPP-QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
G ++A + ++ G PP +I SS+ T V EGQ + L C+V AG+ + W K
Sbjct: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSST--VAEGQTLDLSCVV-AGQAHAQVTWYKR 2281
Query: 806 GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN---------TAGSQHRDVELVV- 855
G LP +RH +R L++ +A AG+Y C A+N G+Q ++
Sbjct: 2282 GGSLP--ARHQVRG-SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG 2338
Query: 856 -QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTL 914
P RI P+++ EG L CV G +TW K +L R G+L
Sbjct: 2339 STQPIRIEPSSSQ--VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRH-----QTHGSL 2391
Query: 915 L-IAQPSAQDAGAYVCTATN-----------TVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
L + Q S D+G YVC T+ + L V RI + S+ A
Sbjct: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE- 2450
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDS 1022
G+ + L+C G VTW K +P +G LRL QV DS
Sbjct: 2451 --------GQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHG----SRLRLLQVTPADS 2498
Query: 1023 GHYECTASNPAGSASHRYVLGVQGRTS 1049
G Y C +G+ ++ +Q R S
Sbjct: 2499 GEYVCRVVGSSGTQEASVLVTIQQRLS 2525
Score = 194 bits (493), Expect = 4e-49
Identities = 214/801 (26%), Positives = 313/801 (39%), Gaps = 97/801 (12%)
Query: 282 YLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLV-------SMAPRIHGYLHQPLLVSCSVH 334
Y + G + GNP V G APLV S+ P+ G H + C V
Sbjct: 1649 YCEQCGPGYVGNP--SVQGGQCLPETNQAPLVVEVHPARSIVPQ--GGSHS---LRCQVS 1701
Query: 335 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
+ P R + R Q S ++ G Y CT + + ++A++
Sbjct: 1702 GSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL 1761
Query: 395 VVTDPPPQLVPAP-----NVTVSPGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVA 448
+VT+ P + + + +V PG C ++P Y L W R G++
Sbjct: 1762 LVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR------LHNGKLP 1815
Query: 449 QLA-DLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSIHTSSQ 500
A D + L I + +D G Y C SN + + + L V+ AP VSIH
Sbjct: 1816 TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQL 1875
Query: 501 HFSQGVEVKVSCSASGYPTPHISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559
G + CSA+G PTP + W+ L ++IH G L + V P D Y
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---GGILRLPAVEPTDQAQYL 1932
Query: 560 CQATNEVGTDQETVTLYY--TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 616
C+A + G L+ P V V G L C A+GVP + W +
Sbjct: 1933 CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKE 1992
Query: 617 -GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 675
G L E + L IPA DAG Y C A + G A A IQ+ V A + P
Sbjct: 1993 GGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPP 2052
Query: 676 RDV-----TVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGV 729
+ +V G++ L C G VTW RRG P ++ GSR R P
Sbjct: 2053 VKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGSRLRLP---- 2105
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-----TGHAPPQIASSAPTVR------ 778
V+P D YVC N G +A + V +G + + S +R
Sbjct: 2106 ----QVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161
Query: 779 -VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYS 837
V EGQ + L C+V G+ + W K G LP +RH L L + +G Y
Sbjct: 2162 HVAEGQTLDLNCVV-PGQAHAQVTWHKRGGSLP--ARHQTHG-SLLRLHQVTPADSGEYV 2217
Query: 838 CVATNTAGSQHRDVELVVQ---VPPRIHPT---ATHHITNEGVPASLPCVASGVPAPTIT 891
C T+G V + ++ +P I P ++ EG L CV +G +T
Sbjct: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT 2277
Query: 892 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
W K +L +R + + L I Q S DAG YVC A+N + S + ++V
Sbjct: 2278 WYKRGGSLPAR----HQVRGSRLYIFQASPADAGQYVCRASNGMEAS---ITVTVTGTQG 2330
Query: 952 IHMNGSRNANVPLQVTAKA-----GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
++ + P+++ + G+ + L+C G VTW K +P +G
Sbjct: 2331 ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGS 2390
Query: 1007 LPSGSLRLAQVQVGDSGHYEC 1027
L LRL Q DSG Y C
Sbjct: 2391 L----LRLYQASPADSGEYVC 2407
Score = 192 bits (487), Expect = 2e-48
Identities = 232/941 (24%), Positives = 354/941 (37%), Gaps = 132/941 (14%)
Query: 297 RVSGVSYSGVA-PGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERH 355
R+SG GVA P S A +G+ L ++C V S P + + L RH
Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHT---LDLNCLVASQAPHTITWYKRGGSL-PSRH 2578
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---------PPQLVPA 406
+ S I + + A+ G Y C + AG+ + + PP + +
Sbjct: 2579 --QIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES 2636
Query: 407 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 466
+ TV G+T L+C V + +TW + LP+ Q L + + D G
Sbjct: 2637 SSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLRLHQMSVADSG 2692
Query: 467 RYQCVASNANGVTRASVWLLVR------EAP----QVSIHTSSQHFSQGVEVKVSCSASG 516
Y C A+N AS+ + V AP + I +SS H ++G + ++C G
Sbjct: 2693 EYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2752
Query: 517 YPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
++W + +L H L + V+P D+G Y C+ G + +V L
Sbjct: 2753 QAHAQVTWHKRGGSLPSH---HQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV-LV 2808
Query: 577 YTDPPSVSAVNAVV--------------LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI 622
+ SAV+ VA G+ L C G +V W++ G +
Sbjct: 2809 TIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP 2868
Query: 623 LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV-----------GHAPQL 671
A LR+ D+G Y+C+ G A + + + G A +
Sbjct: 2869 -ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPI 2927
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
V G++ L C G+ VTW +RG P Q L
Sbjct: 2928 YIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA-----------RHQTHGSQL 2976
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS-----------APTVRV 779
V+P D YVC A + G Q EA VT PP SS P+ V
Sbjct: 2977 RLHLVSPADSGEYVCRAASGPGPEQ-EASFTVT--VPPSEGSSYRLRSPVISIDPPSSTV 3033
Query: 780 LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL-HLDRALQEHAGRYSC 838
+GQ S C++ G W + L I +GS+ + + G Y C
Sbjct: 3034 QQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH--ISPNGSIITIVGTRPSNHGTYRC 3091
Query: 839 VATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTK--E 895
VA+N G V L V PP + + G +L CV++G P + WT+
Sbjct: 3092 VASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISS 3151
Query: 896 TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN 955
T A + + + L I+ DAG YVC A N +G + +++ + V+T
Sbjct: 3152 TPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDT------- 3204
Query: 956 GSRNANVP------LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS 1009
G+ P ++T +AG TL C A GSP P + W+K P+P L
Sbjct: 3205 GAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP----WQHRLEG 3260
Query: 1010 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSV 1069
+L + +V DSG Y C A++PAG A +L V+ P + VP H + +G +V
Sbjct: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES----PPYATTVPEHASVQAGETV 3316
Query: 1070 PLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPLRGPGDAVQR 1129
L A PP S + + +T L + P D+ +
Sbjct: 3317 -------------QLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRY 3363
Query: 1130 PPTTQGRAQWGPGFGRTGVRGEPMKVGLRGSLPGTRGPAGS 1170
+ F + V+G P GSLP T PAGS
Sbjct: 3364 RCRVTNKVGSAEAFAQLLVQGPP------GSLPATSIPAGS 3398
Score = 156 bits (394), Expect = 1e-37
Identities = 130/421 (30%), Positives = 172/421 (40%), Gaps = 39/421 (9%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 425
I R ++ + G Y C A S AG A + V PP + +V GET L C G
Sbjct: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG 3324
Query: 426 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
P W R LP GR +L L P D GRY+C +N G A L
Sbjct: 3325 TPPLTFQWSRVGSSLP---GRATARNEL-LHFERAAPEDSGRYRCRVTNKVGSAEAFAQL 3380
Query: 486 LVR--------------EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 531
LV+ P V + + S G V+ C+ + W +E L
Sbjct: 3381 LVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL 3440
Query: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAV 589
H G L IQ + G Y CQA G Q + L PSV + +V
Sbjct: 3441 PPG---HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSV 3497
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 648
V VG C A G P P+V W + G L P S G +RI + DAG Y C
Sbjct: 3498 QTVVVGHAVEFECLALGDPKPQVTWSKVGGH--LRPGIVQSGGVVRIAHVELADAGQYRC 3555
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
A N G + + L V PQ++ +P++V V G +A+ C A+G P P ++W + DG
Sbjct: 3556 TATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGS 3614
Query: 709 -PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 767
P RL ++ +L SV P+D YVC A N GKV+A A L V
Sbjct: 3615 LPPDSRL-----------ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVV 3663
Query: 768 P 768
P
Sbjct: 3664 P 3664
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/116 (31%), Positives = 48/116 (41%), Gaps = 15/116 (12%)
Query: 835 RYSCVATNTA--GSQHRDVELVVQ--------VPPRIHPTATHHI-TNEGVPASLPCVAS 883
++ CV+TN S H D E +PP++ I + G + CVA
Sbjct: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
Query: 884 GVPAPTITWTKETNALTSRGPHYNVSKE---GTLLIAQPSAQDAGAYVCTATNTVG 936
GVP P I W + S P V+ E GTL+I D GAY C A N G
Sbjct: 432 GVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 764 GHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG- 821
G PPQ+ + +++ GQ V+ C+ + G P P +W + +P R ++ ++G
Sbjct: 402 GCMPPQVVTPPRESIQASRGQTVTFTCVAI-GVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
Query: 822 --SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 879
+L + + G Y+C A N G + V+++ P+ P H E A LP
Sbjct: 461 RGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLP 520
Query: 880 CVASGV 885
C G+
Sbjct: 521 CFCFGI 526
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYS 559
S+G V +C A G PTP I+W + R+ V ++G TLII+ V D G Y+
Sbjct: 419 SRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
Query: 560 CQATNEVG 567
C+A N G
Sbjct: 479 CEAMNARG 486
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/112 (31%), Positives = 46/112 (41%), Gaps = 21/112 (18%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKD-----SRPVPPITNRYGLLPSGSLRLAQVQVG 1020
+ A G+ VT C A G P P++ W + S P +T+ G G+L + V+
Sbjct: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG---RGTLIIRDVKES 472
Query: 1021 DSGHYECTASNPAGSASHRYVLGV-QGRTSWQPQSLPVP-------HHPACL 1064
D G Y C A N G V G+ G PQ P P H ACL
Sbjct: 473 DQGAYTCEAMNARG-----MVFGIPDGVLELVPQRGPCPDGHFYLEHSAACL 519
Score = 40.4 bits (93), Expect = 0.010
Identities = 27/88 (30%), Positives = 36/88 (40%), Gaps = 7/88 (7%)
Query: 669 PQLTELPRD-VTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPD 726
PQ+ PR+ + G++ C A G P P + WR G P R+ + +
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTV-----TSEGG 460
Query: 727 SGVLFFESVAPEDQAPYVCEARNVFGKV 754
G L V DQ Y CEA N G V
Sbjct: 461 RGTLIIRDVKESDQGAYTCEAMNARGMV 488
Score = 38.5 bits (88), Expect = 0.039
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 400 PPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LS 454
PPQ+V P ++ S G+T +C +G + W +W +P S RV ++ +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGT 463
Query: 455 LEISGIIPTDGGRYQCVASNANGV 478
L I + +D G Y C A NA G+
Sbjct: 464 LIIRDVKESDQGAYTCEAMNARGM 487
Score = 35.4 bits (80), Expect = 0.33
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----YRGGLEMILAPEGSSSGKLR 634
P V+ + + G+ C A GVP P + W + + G L
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
Query: 635 IPAAQERDAGTYTCRAVNELG 655
I +E D G YTC A+N G
Sbjct: 466 IRDVKESDQGAYTCEAMNARG 486
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 245 bits (626), Expect = 2e-64
Identities = 200/736 (27%), Positives = 327/736 (44%), Gaps = 64/736 (8%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP--APNVTVSPGETAV 418
N + I R + G Y C+A + GT + V PP+++ +TV G T
Sbjct: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASN 474
L CR G +TW+ + + + + + ++ A D +L + + D G Y+CVASN
Sbjct: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISW----SRES 528
G V + V AP V + Q + G +K+ C+A G P P + W E
Sbjct: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
Query: 529 QALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY----TDPPSV 583
+ LQ +S++ + + GTL I+ +A D G Y C AT+ G+++ V L T P
Sbjct: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
Query: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----------YRGGLEMILAPEGSSSGK 632
+A V G++ +L C A+G P P+++W +R G + + P GS
Sbjct: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS---- 2000
Query: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL--GRSALLAC 690
L I + E+D+G Y C A N++GD + +++ P + + ++ G+ + C
Sbjct: 2001 LFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDC 2060
Query: 691 RATGRPPPTVTWRRGDGQPLGLRLGAG-RGSRSRQP---DSGVLFFESVAPEDQAPYVCE 746
+A+G P P ++W DG + + A G R+R+ ++G L+F V ++ Y C
Sbjct: 2061 KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCY 2120
Query: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806
A+N GK + + L V AP S+ R+ G L C V G P P+ WL
Sbjct: 2121 AQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEV-TGDPKPKIFWLLPS 2179
Query: 807 RPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHP 863
+ S R++ A+GSL +++ +G Y CVA N +G + +L VV PP I+
Sbjct: 2180 NDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLING 2239
Query: 864 TATHHITNEGVPAS-----LPCVASGVPAPTITWTKETNALTSR---GPHYNVSKEGTLL 915
T+ + C A G P+P + W N + G V K GTL
Sbjct: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLE 2299
Query: 916 IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL--QVTAKAGEE 973
I D+ ++C A N G S ++L V + M P ++ A+ G+
Sbjct: 2300 IRNVRLSDSADFICVARNEGGESVLVVQLEV-----LEMLRRPTFRNPFNEKIVAQLGKS 2354
Query: 974 VTLDCEAKGSPPPLVTW-----TKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECT 1028
L+C G+PPP + W T+ S P + +Y + +GS +++ D+G Y C
Sbjct: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNG--PQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
Query: 1029 ASNPAGSASHRYVLGV 1044
A N G +L +
Sbjct: 2413 ARNKVGYIEKLVILEI 2428
Score = 226 bits (577), Expect = 8e-59
Identities = 209/731 (28%), Positives = 304/731 (41%), Gaps = 72/731 (9%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGET 416
N + I + ++ GTYEC A S G+ R + VT P + V+ G+
Sbjct: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
Query: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL----SLEISGIIPTDGGRYQCVA 472
+L+C GE + W + + RV + SL I + D G Y CVA
Sbjct: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
Query: 473 SNANGVTRASVWLLVREAPQVSIHTSSQHFSQ----GVEVKVSCSASGYPTPHISWSRE- 527
N G + + +R P H Q+F + G + +V C ASG P P ISWS
Sbjct: 2019 RNKMGDDLILMHVSLRLKPAKIDH--KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPD 2076
Query: 528 ----SQALQEDSRIHVDAQ------GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-Y 576
+ A+Q D H + GTL V + G+Y+C A N +G D+ V L
Sbjct: 2077 GTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136
Query: 577 YTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSG 631
T P + N + G+ AVL CE +G P P++ W +MI ++G
Sbjct: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
Query: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQL-AVGHAPQLTELPRDVTVELGRSALLA- 689
L I + D+G Y C A N GD + +L V P + L + TV + +
Sbjct: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
Query: 690 ----CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
CRA G P P V W D L GSR +G L +V D A ++C
Sbjct: 2257 KHFDCRAEGTPSPEVMWIMPDNIFL---TAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
Query: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWL 803
ARN G+ +L V + +++ G+ +L C V G P PE W+
Sbjct: 2314 VARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSV-DGNPPPEIIWI 2372
Query: 804 KDGRPLPPGSRHS---------IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 854
LP G+R S I ++GS + + +E AG+Y C A N G + V L
Sbjct: 2373 -----LPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILE 2427
Query: 855 VQVPPRIHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSR---GPHYNVSK 910
+ P I A + G SL CV+ G+P P I WT + + R Y +
Sbjct: 2428 IGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD 2487
Query: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
GTL+I + +A D G Y+C A N+VG + + + + P N P + +
Sbjct: 2488 NGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITN-----RPPRSIVTRT 2542
Query: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR---YG---LLPSGSLRLAQVQVGDSGH 1024
G L C A G P P +TW + ++ +G L G+L + Q DSG
Sbjct: 2543 GAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGI 2602
Query: 1025 YECTASNPAGS 1035
Y+CTA NP GS
Sbjct: 2603 YKCTAKNPLGS 2613
Score = 205 bits (522), Expect = 2e-52
Identities = 187/677 (27%), Positives = 279/677 (41%), Gaps = 55/677 (8%)
Query: 406 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS----TGRVAQLADLSLEISGII 461
A + T+ A L C +G + W R L S RV L + +L I +
Sbjct: 1655 AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE 1714
Query: 462 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPT 519
D G+Y C ASN G V L V P + ++ + G V++ C A G P+
Sbjct: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
Query: 520 PHISWSRESQALQEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 574
P ++W +Q + +S + V GTL++ ++ D G Y C A+N G D V
Sbjct: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVK 1834
Query: 575 L-YYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---- 628
+ PP + V+V GE L C A G P P V W + + +
Sbjct: 1835 IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
Query: 629 ---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH---APQLTELPRDVT-VE 681
S+G L I D GTY C A + G + L + +P++ + T V
Sbjct: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVN 1954
Query: 682 LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA 741
G LL C ATG P P + WR + + GS +G LF SV +D
Sbjct: 1955 FGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRV--GSWIHVYPNGSLFIGSVTEKDSG 2012
Query: 742 PYVCEARNVFGK----VQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRP 796
Y+C ARN G + RL P +I +VL G+ + C +G P
Sbjct: 2013 VYLCVARNKMGDDLILMHVSLRL-----KPAKIDHKQYFRKQVLHGKDFQVDC-KASGSP 2066
Query: 797 LPERHW-LKDGRPLPPG----------SRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
+PE W L DG + R+++ +G+L+ ++ G Y+C A NT G
Sbjct: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
Query: 846 SQHRDVEL-VVQVPPRIHPT-ATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
V L V+ PRI + T+ G A L C +G P P I W +N + S
Sbjct: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFS 2186
Query: 904 -PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Y G+L I + D+G YVC A N G ++ +L V +KP + +NG
Sbjct: 2187 IDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPL-INGLYTNRT 2245
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR---PVPPITNRYGLLPSGSLRLAQVQV 1019
++ TA + DC A+G+P P V W P +R + +G+L + V++
Sbjct: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRL 2305
Query: 1020 GDSGHYECTASNPAGSA 1036
DS + C A N G +
Sbjct: 2306 SDSADFICVARNEGGES 2322
Score = 202 bits (513), Expect = 2e-51
Identities = 188/713 (26%), Positives = 298/713 (41%), Gaps = 64/713 (8%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETAVLSCRVLGEAPYN 430
+ G Y+C A + G +I V PP ++ + + GE+ L C G +
Sbjct: 1814 DRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
Query: 431 LTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 486
+ WV + + L + ++ ++ +L I + +D G Y+C+A+++ G R V L
Sbjct: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
Query: 487 VRE-APQVSIHTSSQHFSQ---GVEVKVSCSASGYPTPHISWSRESQALQED-----SRI 537
+ E I +SQ ++ G ++ ++CSA+G P P I W S+A+ + S I
Sbjct: 1934 MEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
Query: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV--G 595
HV G+L I V +D+G Y C A N++G D + + P+ V G
Sbjct: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG 2053
Query: 596 EEAVLVCEASGVPPPRVIWYRGGLEMI---LAPEGS----------SSGKLRIPAAQERD 642
++ + C+ASG P P + W MI + + S ++G L +
Sbjct: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
Query: 643 AGTYTCRAVNELGDASAEIQLAV-GHAPQLTELPR-DVTVELGRSALLACRATGRPPPTV 700
G YTC A N LG ++ L V AP++ + + + ++ G +A+L C TG P P +
Sbjct: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKI 2173
Query: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
W + + R +G L V D YVC ARN G +L
Sbjct: 2174 FWLLPSNDMISFSI-----DRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKL 2228
Query: 761 IVTGHAPPQIASSAPTVRVLEGQPVS-----LPCIVLAGRPLPERHWLKDGRPLPP---- 811
V PP I V++ V C G P PE W+
Sbjct: 2229 DVVSK-PPLINGLYTNRTVIKATAVRHSKKHFDCRA-EGTPSPEVMWIMPDNIFLTAPYY 2286
Query: 812 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----QVPPRIHPTATH 867
GSR ++ +G+L + + + CVA N G V+L V + P +P
Sbjct: 2287 GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK 2346
Query: 868 HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH---YNVSKEGTLLIAQPSAQDA 924
+ G +L C G P P I W S GP Y ++ G+ +I++ + +DA
Sbjct: 2347 IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA 2406
Query: 925 GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
G Y C A N VG+ + + L + KP I P V +GE ++L C + G P
Sbjct: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVI------LTYAPGTVKGISGESLSLHCVSDGIP 2460
Query: 985 PPLVTWTKDSRPV---PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
P + WT S V P I +Y L +G+L + + D G+Y C A N G
Sbjct: 2461 KPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVG 2513
Score = 195 bits (495), Expect = 3e-49
Identities = 173/577 (29%), Positives = 241/577 (41%), Gaps = 60/577 (10%)
Query: 512 CSASGYPTPHISWSRESQAL-----QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV 566
C A G P P I W+R L +++SR+ V GTL IQ V +D G Y C A+N
Sbjct: 1670 CEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLF 1729
Query: 567 GTDQETVTLYYTD-PPSV-SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA 624
GTD VTL PP + + V G L C A G P P V W ++
Sbjct: 1730 GTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSE 1789
Query: 625 PEGSS-------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-LTELPR 676
S G L + D G Y C A N G S +++ V AP + E R
Sbjct: 1790 SSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRR 1849
Query: 677 DVTV-ELGRSALLACRATGRPPPTVTWRRGDG---QPLGLRLGAGRGSRSRQPDSGVLFF 732
V V G S L C A G P P+V W DG +PL S+ +G L+
Sbjct: 1850 QVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQF-----TNSKLFLFSNGTLYI 1904
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH--APPQIASSAPTVRVLEGQPVSLPCI 790
++A D+ Y C A + G + L + +P A+S V G + L C
Sbjct: 1905 RNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCS 1964
Query: 791 VLAGRPLPERHWLKDGRPLPP-----GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
G P P+ W + + GS + +GSL + ++ +G Y CVA N G
Sbjct: 1965 A-TGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
Query: 846 SQHRDVELVVQVPPRIHPTATHH------ITNEGVPASLPCVASGVPAPTITW-----TK 894
D +++ V R+ P H G + C ASG P P I+W T
Sbjct: 2024 ----DDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM 2079
Query: 895 ETNALTS-----RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT- 948
NA+ + R Y + GTL + + G Y C A NT+G ++ L+V T
Sbjct: 2080 INNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA 2139
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT-NRYGLL 1007
PRI + N + KAG+ LDCE G P P + W S + + +RY
Sbjct: 2140 APRIRQSNKTNKRI------KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFH 2193
Query: 1008 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
+GSL + +V++ DSG Y C A NP+G + Y L V
Sbjct: 2194 ANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Score = 169 bits (427), Expect = 2e-41
Identities = 142/492 (28%), Positives = 217/492 (44%), Gaps = 44/492 (8%)
Query: 577 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS-----S 629
+ P V A + +A L CEA G P P + W R GL++ + S
Sbjct: 1645 FEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP 1704
Query: 630 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA-VGHAPQLTE-LPRDVTVELGRSAL 687
+G L I + +D G Y C A N G + L+ V + P++ E +++TV G +
Sbjct: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
Query: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCE 746
L CRA GRP PTVTW + + + +GSR G L +++ D+ Y C
Sbjct: 1765 LKCRAEGRPSPTVTWILANQTVVS---ESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV 1821
Query: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHW-LK 804
A N G+ ++ V APP I V V G+ + LPC G P P +W L
Sbjct: 1822 ASNPGGQDSLLVKIQVIA-APPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLS 1879
Query: 805 DGRPLPP----GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ---V 857
DG + P S+ + ++G+L++ G Y C+AT++ GS+ R V L ++
Sbjct: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
Query: 858 PPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSR----GPHYNVSKEG 912
PRI + N G L C A+G P P I W + A+ + G +V G
Sbjct: 1940 SPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG 1999
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
+L I + +D+G Y+C A N +G M +S+ KP + + G+
Sbjct: 2000 SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP-----AKIDHKQYFRKQVLHGK 2054
Query: 973 EVTLDCEAKGSPPPLVTWT-KDSRPVPPI---------TNRYGLLPSGSLRLAQVQVGDS 1022
+ +DC+A GSP P ++W+ D + T RY L +G+L +V V +
Sbjct: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
Query: 1023 GHYECTASNPAG 1034
G Y C A N G
Sbjct: 2115 GDYTCYAQNTLG 2126
Score = 163 bits (412), Expect = 1e-39
Identities = 170/661 (25%), Positives = 263/661 (39%), Gaps = 58/661 (8%)
Query: 327 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESG-----NSSWEILRASKAEEGTYECTA 381
LL++CS ++ R + +++H S N S I ++ + G Y C A
Sbjct: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
Query: 382 VSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTW-VRDWR 438
++ G + + P ++ V G+ + C+ G ++W + D
Sbjct: 2019 RNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGT 2078
Query: 439 VLPAS---------TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL-LVR 488
++ + T R + +L + + + G Y C A N G V L ++
Sbjct: 2079 MINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT 2138
Query: 489 EAPQV-SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS--RIHVDAQGTL 545
AP++ + +++ G + C +G P P I W S + S R A G+L
Sbjct: 2139 AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSL 2198
Query: 546 IIQGVAPEDAGNYSCQATNEVGTDQETVTL-YYTDPPSVSAV--NAVVLVAVG---EEAV 599
I V D+G Y C A N G D + L + PP ++ + N V+ A +
Sbjct: 2199 TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
Query: 600 LVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNE 653
C A G P P V+W + AP S +G L I + D+ + C A NE
Sbjct: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
Query: 654 LGDASAEIQLAVGHAPQL----TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709
G++ +QL V + + +LG+S L C G PPP + W P
Sbjct: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL----P 2374
Query: 710 LGLRLGAGRGSRSRQ-PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
G R G S +G ED Y C ARN G ++ + ++ G P
Sbjct: 2375 NGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE-KLVILEIGQKPV 2433
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG-----RPLPPGSRHSIRADGSL 823
+ + TV+ + G+ +SL C V G P P W RP G ++ + +G+L
Sbjct: 2434 ILTYAPGTVKGISGESLSLHC-VSDGIPKPNIKWTMPSGYVVDRPQING-KYILHDNGTL 2491
Query: 824 HLDRALQEHAGRYSCVATNTAGSQHRDVE-LVVQVPPRIHPTATHHI-TNEGVPASLPCV 881
+ A G Y C A N+ G V ++V PPRI I T G L CV
Sbjct: 2492 VIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCV 2551
Query: 882 ASGVPAPTITWTKETNALTSRGP------HYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
A GVP P ITW ++L S + +GTL+I P D+G Y CTA N +
Sbjct: 2552 ALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL 2611
Query: 936 G 936
G
Sbjct: 2612 G 2612
Score = 160 bits (406), Expect = 5e-39
Identities = 143/527 (27%), Positives = 214/527 (40%), Gaps = 37/527 (7%)
Query: 354 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 411
R + N + + AEEG Y C A + G K + V P++ + N +
Sbjct: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI 2153
Query: 412 SPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQC 470
G+TAVL C V G+ + W+ ++ S R A+ SL I+ + D G Y C
Sbjct: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVC 2213
Query: 471 VASNANGVTRASVWL-LVREAPQVSIHTSSQHFSQGVEVKVS-----CSASGYPTPHISW 524
VA N +G L +V + P ++ +++ + V+ S C A G P+P + W
Sbjct: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
Query: 525 SRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD- 579
A SRI V GTL I+ V D+ ++ C A NE G V L +
Sbjct: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
Query: 580 ---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPEG-----SSS 630
P + N ++ +G+ L C G PPP +IW G P+ +S+
Sbjct: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASN 2393
Query: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-LTELPRDVTVELGRSALLA 689
G I DAG Y C A N++G + L +G P LT P V G S L
Sbjct: 2394 GSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLH 2453
Query: 690 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749
C + G P P + W G + G+ D+G L + D+ Y+C+A+N
Sbjct: 2454 CVSDGIPKPNIKWTMPSGYVVDRPQINGKYILH---DNGTLVIKEATAYDRGNYICKAQN 2510
Query: 750 VFGKVQAEARLIVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGR 807
G +++ + PP+I + P ++ G L C+ L G P PE W + D
Sbjct: 2511 SVGHTLITVPVMIVAY-PPRITNRPPRSIVTRTGAAFQLHCVAL-GVPKPEITWEMPDHS 2568
Query: 808 PLPPGSRHSIRADGSLHLDRAL------QEHAGRYSCVATNTAGSQH 848
L S+ LHL L +G Y C A N GS +
Sbjct: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
Score = 123 bits (308), Expect = 1e-27
Identities = 89/298 (29%), Positives = 133/298 (44%), Gaps = 21/298 (7%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK-----DGRPLPPGSRHSIRADG 821
P + A + + LPC + G PLP HW + D SR + +G
Sbjct: 1648 PRIVGGKAASFTIPANSDAFLPCEAV-GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNG 1706
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT-NEGVPASLP 879
+L + R + G+Y C A+N G+ H V L VV PPRI T IT + G L
Sbjct: 1707 TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELK 1766
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYN----VSKEGTLLIAQPSAQDAGAYVCTATNTV 935
C A G P+PT+TW + S + V+ +GTL++ S D G Y C A+N
Sbjct: 1767 CRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
Query: 936 GFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT-KDS 994
G S +++ V P + + R + GE + L C AKG+P P V W D
Sbjct: 1827 GQDSLLVKIQVIAAPPVILEQRRQV-----IVGTWGESLKLPCTAKGTPQPSVYWVLSDG 1881
Query: 995 RPVPPI---TNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
V P+ ++ L +G+L + + D G YEC A++ GS +L ++ R +
Sbjct: 1882 TEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
Score = 89.0 bits (219), Expect = 3e-17
Identities = 84/336 (25%), Positives = 131/336 (38%), Gaps = 39/336 (11%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD----PPPQLVPAPNVTVSPGET 416
N + EI ++ + C A + G Q+ V + P + + G++
Sbjct: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
Query: 417 AVLSCRVLGEAPYNLTWV-----------RDWRVLPASTGRVAQLADLSLEISGIIPTDG 465
L+C V G P + W+ + ++ L AS G S IS D
Sbjct: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--------SFIISKTTREDA 2406
Query: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISW 524
G+Y+C A N G V L + + P + + + G + + C + G P P+I W
Sbjct: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 525 SRESQALQEDSRIH----VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV-TLYYTD 579
+ S + + +I+ + GTL+I+ D GNY C+A N VG TV +
Sbjct: 2467 TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY 2526
Query: 580 PPSVS-AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSS--- 630
PP ++ ++ G L C A GVP P + W ++ GS
Sbjct: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
Query: 631 -GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
G L I Q D+G Y C A N LG A + V
Sbjct: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 12/163 (7%)
Query: 505 GVEVKVSCSASGYPTPHISW------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 558
G V ++C G PTPH+ W + + ED RI +D G L +Q D G Y
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
Query: 559 SCQATNEVGTDQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 616
C ++N D T + +P + V +GE L C ++G+P + W
Sbjct: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
Query: 617 GGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRAVNELG 655
G ++ ++G LRI +D G Y C A N G
Sbjct: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 61.6 bits (148), Expect = 4e-09
Identities = 47/181 (25%), Positives = 73/181 (40%), Gaps = 11/181 (6%)
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITW-----TKETNALTSRGPHYNVSKEGTL 914
R + T H G L C G P P + W +K S + K G L
Sbjct: 477 RDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKL 536
Query: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
+ + D G Y C ++N R++V +P + + T GE +
Sbjct: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITV-VEPLVEAYQENG----IHHTVFIGETL 591
Query: 975 TLDCEAKGSPPPLVTWTKDSRPVPPITNR-YGLLPSGSLRLAQVQVGDSGHYECTASNPA 1033
L C + G P ++W V ++R +L +G+LR+ QV D G+Y C A+NP+
Sbjct: 592 DLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPS 651
Query: 1034 G 1034
G
Sbjct: 652 G 652
Score = 58.9 bits (141), Expect = 3e-08
Identities = 53/180 (29%), Positives = 68/180 (37%), Gaps = 10/180 (5%)
Query: 779 VLEGQPVSLPCIVLAGRPLPERHWL-KDGRPL-----PPGSRHSIRADGSLHLDRALQEH 832
VL G V L C G P P WL DG + R I G L L A
Sbjct: 487 VLVGGTVGLNCPG-QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 833 AGRYSCVATNTAGSQHRDVELVVQVP--PRIHPTATHHITNEGVPASLPCVASGVPAPTI 890
G Y C+++N + + V P HH G LPC ++G+P +I
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Query: 891 TWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
+W N L V GTL I Q + +D G Y C A N G ++SV K
Sbjct: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/174 (28%), Positives = 69/174 (39%), Gaps = 21/174 (12%)
Query: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--------SSGKLRIPAAQERDA 643
V VG L C G P P V W + AP S SGKL + A D
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 644 GTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD----VTVELGRSALLACRATGRPPPT 699
G Y C + N D + + + L E ++ TV +G + L C +TG P +
Sbjct: 547 GVYHCISSNY--DDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDAS 604
Query: 700 VTWRRGDGQPLGLRLGAGRGSRSRQP-DSGVLFFESVAPEDQAPYVCEARNVFG 752
++W L + SR ++ ++G L V P+DQ Y C A N G
Sbjct: 605 ISWVIPGNNVL------YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 48.1 bits (113), Expect = 5e-05
Identities = 49/178 (27%), Positives = 74/178 (41%), Gaps = 27/178 (15%)
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPASTGRVA-QLADLSL 455
TV G T L+C G+ ++ W+ D R+L +G++ Q+AD
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--- 542
Query: 456 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCS 513
D G Y C++SN + + + V E + + H + G + + C
Sbjct: 543 ------SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
Query: 514 ASGYPTPHISWSRE-SQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 569
++G P ISW + L + SR V GTL I V P+D G Y C A N G D
Sbjct: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-----TKDSRPVPPITNRYGLLPSGS 1011
SR+ N L+ T G V L+C +G P P V W +K P R + SG
Sbjct: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535
Query: 1012 LRLAQVQVGDSGHYECTASN 1031
L L D+G Y C +SN
Sbjct: 536 LELQMADSFDTGVYHCISSN 555
Score = 37.0 bits (84), Expect = 0.11
Identities = 44/169 (26%), Positives = 62/169 (36%), Gaps = 4/169 (2%)
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
TV +G + L C G P P V W DG + + G R SG L +
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDG-RILIDKSGKLELQMADSF 544
Query: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP 798
D Y C + N R+ V + V G+ + LPC G P
Sbjct: 545 DTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC-HSTGIPDA 603
Query: 799 ERHWLKDG-RPLPPGSR-HSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
W+ G L SR + +G+L + + + G Y CVA N +G
Sbjct: 604 SISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 245 bits (625), Expect = 2e-64
Identities = 208/733 (28%), Positives = 320/733 (43%), Gaps = 64/733 (8%)
Query: 354 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 411
+ F+ N + I + + G Y CTA + G R + VT PQ++ + +VTV
Sbjct: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Query: 412 SPGETAVLSCRVLGEAPYNLTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 467
G+T + C G ++W+ R W+ + GR+ + +L I +D G
Sbjct: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
Query: 468 YQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISW- 524
Y+CVASNA G ++ L V P V ++ S G+ + + C+A P P + W
Sbjct: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
Query: 525 ------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
R SQ L + V GTL I+ +AP+D+G Y C A N VG+ + TV L
Sbjct: 2083 LGDGTQIRPSQFLH--GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
Query: 579 DPPSVSAVNAV----VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS---- 630
+ + + V G L C ASG P PR++W MI A S
Sbjct: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
Query: 631 ---GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE--LPRDVTVELGRS 685
G L + + ++DAG Y C A N++GD +++ V P E D V G
Sbjct: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
Query: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRL----GAGRGSRSRQPDSGVLFFESVAPEDQA 741
+ C ATG P P ++W DG + + GR R ++G L+F V ++
Sbjct: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
Query: 742 PYVCEARNVFGKVQAEARLIVTGHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPER 800
Y C A N GK + R+ V AP I + V+V G V++ C G P+P+
Sbjct: 2321 DYTCFAENQVGKDEMRVRVKVV-TAPATIRNKTYLAVQVPYGDVVTVAC-EAKGEPMPKV 2378
Query: 801 HWLKDGRPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV- 857
WL + P S ++ I DG+L + +A + +G Y+C+ N+AG + V + V V
Sbjct: 2379 TWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
Query: 858 PPRIHP-----TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY----NV 908
PP+I+ T I G + C A G+P P + W + P+Y V
Sbjct: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLP-APYYGNRITV 2497
Query: 909 SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV---NTKPRIHMNGSRNANVPLQ 965
G+L I D+ VC A N G + ++L+V KP H + +
Sbjct: 2498 HGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH------DPISEK 2551
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWT----KDSRPVPPITNRYGLLPSGSLRLAQVQVGD 1021
+TA AG ++L+C A G+P P + W D + + R+ G L ++ + D
Sbjct: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL-QRFYHKADGMLHISGLSSVD 2610
Query: 1022 SGHYECTASNPAG 1034
+G Y C A N AG
Sbjct: 2611 AGAYRCVARNAAG 2623
Score = 209 bits (532), Expect = 1e-53
Identities = 209/731 (28%), Positives = 287/731 (39%), Gaps = 68/731 (9%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV---PAPNVT-VSPGET 416
N + I + + G YEC A + G+ R Q+ V +P T V G T
Sbjct: 2104 NGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGT 2163
Query: 417 AVLSCRVLGEAPYNLTW----VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA 472
L C G+ + W R L + R+ A+ +L + + D G Y CVA
Sbjct: 2164 LKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVA 2223
Query: 473 SNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQA 530
N G + + V P H G ++KV C A+G P P ISWS +
Sbjct: 2224 RNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS 2283
Query: 531 L------QEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 579
L +DS R V GTL V + G+Y+C A N+VG D+ V +
Sbjct: 2284 LVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVT 2343
Query: 580 PPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS------G 631
P+ + V V G+ + CEA G P P+V W ++I P S G
Sbjct: 2344 APATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVI--PTSSEKYQIYQDG 2401
Query: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG-HAPQLTELPRDVTVEL-----GRS 685
L I AQ D+G YTC N G+ + + V P++ P +T G
Sbjct: 2402 TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSR 2461
Query: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
L+ C+A G P P V W +G L G+R +G L S+ D VC
Sbjct: 2462 KLIDCKAEGIPTPRVLWAFPEGVVLPAPY---YGNRITVHGNGSLDIRSLRKSDSVQLVC 2518
Query: 746 EARNVFGKVQAEARLIVTGHAPPQIASS--APTVRVLEGQPVSLPCIVLAGRPLPERHW- 802
ARN G+ + +L V I + + + G +SL C AG P P W
Sbjct: 2519 MARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSA-AGTPTPSLVWV 2577
Query: 803 LKDGRPLPPGS---RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
L +G L G R +ADG LH+ AG Y CVA N AG R V L V + P
Sbjct: 2578 LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
Query: 860 RIHPTATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRGPH----YNVSKEGT 913
+ H++ + G LPC G +WT N + GP ++ GT
Sbjct: 2638 EANKQY-HNLVSIINGETLKLPCTPPGAGQGRFSWTLP-NGMHLEGPQTLGRVSLLDNGT 2695
Query: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVT-AKAGE 972
L + + S D G YVC G S + + V P R + P V + G
Sbjct: 2696 LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP------PRITSEPTPVIYTRPGN 2749
Query: 973 EVTLDCEAKGSPPPLVTWT---KDSRPVPPITNRYG---LLPSGSLRLAQVQVGDSGHYE 1026
V L+C A G P +TW K YG L P GSL + D+G Y+
Sbjct: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
Query: 1027 CTASNPAGSAS 1037
C A N GS S
Sbjct: 2810 CMAKNILGSDS 2820
Score = 206 bits (523), Expect = 1e-52
Identities = 178/616 (28%), Positives = 269/616 (43%), Gaps = 47/616 (7%)
Query: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKV--SCSA 514
I+ + + G +Q + G AS + + E PQ+ + S Q S E C A
Sbjct: 1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI-LTKSPQTVSVTAETDTVFPCEA 1877
Query: 515 SGYPTPHISWSRESQ-ALQEDS----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 569
+G P P ++W++ S AL + R V GTL+I+ V +D G Y C A+N G D
Sbjct: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLD 1937
Query: 570 QETVTLYYT--DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY---RGGLEMILA 624
+ V L T P +++ V V +G+ + C A G P P++ W R + +
Sbjct: 1938 RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
Query: 625 PEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDV 678
EG + L I A D G Y C A N G S I+L V P + E ++
Sbjct: 1998 VEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENI 2057
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
++ G S + C A P P+V W GDG +R +G L+ ++AP+
Sbjct: 2058 SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQ--IRPSQFLHGNLFVFPNGTLYIRNLAPK 2115
Query: 739 DQAPYVCEARNVFGKVQAEARL-IVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRP 796
D Y C A N+ G + +L + A +I ++P V G + L C +G P
Sbjct: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSA-SGDP 2174
Query: 797 LPERHWLKDGRPLPPG-----SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851
P W + + SR + A+G+L + + AG Y CVA N G + +
Sbjct: 2175 WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
Query: 852 EL-VVQVPPRI-HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS-------- 901
++ VV P +I H H G + CVA+G+P P I+W+ +L +
Sbjct: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDS 2294
Query: 902 --RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
R Y V GTL + ++ G Y C A N VG +R+ V T P N
Sbjct: 2295 GGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN---- 2350
Query: 960 ANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-TKDSRPVPPITNRYGLLPSGSLRLAQVQ 1018
L V G+ VT+ CEAKG P P VTW + ++ +P + +Y + G+L + + Q
Sbjct: 2351 -KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
Query: 1019 VGDSGHYECTASNPAG 1034
DSG+Y C N AG
Sbjct: 2410 RSDSGNYTCLVRNSAG 2425
Score = 204 bits (518), Expect = 5e-52
Identities = 193/723 (26%), Positives = 292/723 (40%), Gaps = 60/723 (8%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL--VPAPNVTVSPGETAV 418
N + I AS ++ G Y+C A + AG ++ V PP + N+++ PG +
Sbjct: 2007 NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIH 2066
Query: 419 LSCRVLGEAPYNLTWVRD--WRVLPAST--GRVAQLADLSLEISGIIPTDGGRYQCVASN 474
+ C ++ WV ++ P+ G + + +L I + P D GRY+CVA+N
Sbjct: 2067 IHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAAN 2126
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQ----HFSQGVEVKVSCSASGYPTPHISWSRESQA 530
G R +V L V+ A + T + G +K+ CSASG P P I W S+
Sbjct: 2127 LVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKR 2186
Query: 531 LQE-----DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS--V 583
+ + DSRI V A GTL+++ V +DAG+Y C A N+VG D + + P+
Sbjct: 2187 MIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIE 2246
Query: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY--RGGLEMILAPEGSSSGK--------- 632
V G + + C A+G+P P + W G L S G+
Sbjct: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
Query: 633 --LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL--GRSALL 688
L R+ G YTC A N++G +++ V AP + V++ G +
Sbjct: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTV 2366
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
AC A G P P VTW + + + + G L + D Y C R
Sbjct: 2367 ACEAKGEPMPKVTWLSPTNKVI-----PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVR 2421
Query: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE---GQPVSLPCIVLAGRPLPERHW-LK 804
N G+ + + V P + P V E G L G P P W
Sbjct: 2422 NSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP 2481
Query: 805 DGRPLPP---GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP--- 858
+G LP G+R ++ +GSL + + + + C+A N G ++L V P
Sbjct: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
Query: 859 PRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRG---PHYNVSKEGTL 914
P H + IT G SL C A+G P P++ W G + +G L
Sbjct: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGML 2601
Query: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
I+ S+ DAGAY C A N G + + + L V KP N V+ GE +
Sbjct: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP------EANKQYHNLVSIINGETL 2655
Query: 975 TLDCEAKGSPPPLVTWTKDS---RPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
L C G+ +WT + P R LL +G+L + + V D G Y C
Sbjct: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMET 2715
Query: 1032 PAG 1034
G
Sbjct: 2716 EYG 2718
Score = 152 bits (383), Expect = 2e-36
Identities = 131/530 (24%), Positives = 208/530 (39%), Gaps = 35/530 (6%)
Query: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT 410
G + + N + EEG Y C A ++ G + ++ V P + +
Sbjct: 2296 GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA 2355
Query: 411 VSP--GETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDGGR 467
V G+ ++C GE +TW+ +V+P S+ + D +L I +D G
Sbjct: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
Query: 468 YQCVASNANGVTRASVWLLVR-EAPQVS-----IHTSSQHFSQGVEVKVSCSASGYPTPH 521
Y C+ N+ G R +VW+ V + P+++ I T + + G + C A G PTP
Sbjct: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Query: 522 ISWSRES----QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
+ W+ A +RI V G+L I+ + D+ C A NE G + + L
Sbjct: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
Query: 578 TDPPSV----SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPE-----G 627
+P ++ + G L C A+G P P ++W G ++ +
Sbjct: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH 2595
Query: 628 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD-VTVELGRSA 686
+ G L I DAG Y C A N G + L VG P+ + + V++ G +
Sbjct: 2596 KADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETL 2655
Query: 687 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746
L C G +W +G L GR S D+G L + D+ YVC
Sbjct: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL---DNGTLTVREASVFDRGTYVCR 2712
Query: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP-------LPE 799
+G +IV + P + P + G V L C+ + G P LP+
Sbjct: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM-GIPKADITWELPD 2771
Query: 800 RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 849
+ LK G + GSL + A Q AG Y C+A N GS +
Sbjct: 2772 KSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
Score = 150 bits (378), Expect = 9e-36
Identities = 142/516 (27%), Positives = 214/516 (41%), Gaps = 43/516 (8%)
Query: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHTS--SQHFSQGVEVKVSCSASGYPTPHIS 523
G Y C A N G V + V AP + + + G V V+C A G P P ++
Sbjct: 2320 GDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
Query: 524 WSRESQALQEDS--RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT-DP 580
W + + S + + GTL+IQ D+GNY+C N G D++TV ++ P
Sbjct: 2380 WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
Query: 581 PSVSA----VNAVVLVAVGEEAVLV-CEASGVPPPRVIWYRGGLEMILAPEGSS------ 629
P ++ + V +A G L+ C+A G+P PRV+W ++ AP +
Sbjct: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
Query: 630 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT----ELPRDVTVELGRS 685
+G L I + ++ D+ C A NE G+A +QL V + + +T G +
Sbjct: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
Query: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG-SRSRQPDSGVLFFESVAPEDQAPYV 744
L C A G P P++ W P G L +G+ R G+L ++ D Y
Sbjct: 2560 ISLNCSAAGTPTPSLVWVL----PNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
Query: 745 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLA---GR---PLP 798
C ARN G + L V G P V ++ G+ + LPC GR LP
Sbjct: 2616 CVARNAAGHTERLVSLKV-GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
Query: 799 ERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE-LVVQV 857
L+ + L R S+ +G+L + A G Y C G + +V+
Sbjct: 2675 NGMHLEGPQTL---GRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAY 2731
Query: 858 PPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV------SK 910
PPRI T I T G L C+A G+P ITW + G +
Sbjct: 2732 PPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHP 2791
Query: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+G+L I + +DAG Y C A N +G S+ + V
Sbjct: 2792 QGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Score = 146 bits (368), Expect = 1e-34
Identities = 137/482 (28%), Positives = 197/482 (40%), Gaps = 40/482 (8%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP-------EGSSSGKLRIPAAQERD 642
V V + V CEA+G P P V W + ++ P E +G L I Q +D
Sbjct: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
Query: 643 AGTYTCRAVNELGDASAEIQLAVG-HAPQ-LTELPRDVTVELGRSALLACRATGRPPPTV 700
G Y C A N G + L+V PQ L +DVTV LG + + C A G P P +
Sbjct: 1923 RGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQI 1982
Query: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
+W D + + + G R ++ L + + D+ Y C A N G RL
Sbjct: 1983 SWIFPDRR-VWQTVSPVEG-RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
Query: 761 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGRPLPPGS----RH 815
V P + + G + + C A PLP W L DG + P
Sbjct: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAA-PLPSVRWVLGDGTQIRPSQFLHGNL 2099
Query: 816 SIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ---VPPRIHPTATHHI-TN 871
+ +G+L++ + +GRY CVA N GS R V+L VQ RI T+
Sbjct: 2100 FVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVR 2159
Query: 872 EGVPASLPCVASGVPAPTITWT----KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 927
G L C ASG P P I W + +AL S V GTL++ + +DAG Y
Sbjct: 2160 YGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDY 2219
Query: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
+C A N VG +++ V KP + N + G ++ +DC A G P P
Sbjct: 2220 LCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY-----GGDLKVDCVATGLPNPE 2274
Query: 988 VTWT----------KDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
++W+ S T RY + +G+L +V + + G Y C A N G
Sbjct: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
Query: 1038 HR 1039
R
Sbjct: 2335 MR 2336
Score = 105 bits (262), Expect = 3e-22
Identities = 90/295 (30%), Positives = 130/295 (44%), Gaps = 24/295 (8%)
Query: 768 PQIASSAP-TVRVLEGQPVSLPCIVLAGRPLPERHWLK--DGRPLPPGSR---HSIRADG 821
PQI + +P TV V PC G+P P W K G + P +R + +G
Sbjct: 1853 PQILTKSPQTVSVTAETDTVFPCEA-TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP-PRIHPTATHHITNE-GVPASLP 879
+L + + + G+Y C A+N G V L V V P+I + +T G ++
Sbjct: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
Query: 880 CVASGVPAPTITWT----KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
C+A G PAP I+W + ++ + + TL I + S D G Y C A+N
Sbjct: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
Query: 936 GFSSQEMRLSVNTKPR-IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-D 993
G S +RL V P IH N ++P G + + C AK +P P V W D
Sbjct: 2032 GADSLAIRLHVAALPPVIHQEKLENISLP------PGLSIHIHCTAKAAPLPSVRWVLGD 2085
Query: 994 SRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ P +G L P+G+L + + DSG YEC A+N GSA L VQ
Sbjct: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
Score = 98.6 bits (244), Expect = 3e-20
Identities = 73/222 (32%), Positives = 107/222 (48%), Gaps = 27/222 (12%)
Query: 879 PCVASGVPAPTITWTK-ETNAL---TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 934
PC A+G P P +TWTK T AL +R + V K GTL+I + QD G Y+CTA+N
Sbjct: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNL 1933
Query: 935 VGFSSQEMRLSVNT-KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD 993
G + LSV +P+I + ++ VT G+ + ++C AKG+P P ++W
Sbjct: 1934 HGLDRMVVLLSVTVQQPQILASHYQD------VTVYLGDTIAMECLAKGTPAPQISWIFP 1987
Query: 994 SR----PVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
R V P+ R L + +L + + D G Y+C ASN AG+ S L V
Sbjct: 1988 DRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHV----- 2042
Query: 1050 WQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLP 1091
+LP H L +S+ P S+ + + APLP
Sbjct: 2043 ---AALPPVIHQEKLENISL----PPGLSIHIHCTAKAAPLP 2077
Score = 66.6 bits (161), Expect = 1e-10
Identities = 65/253 (25%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
LP L+ G+ + + F + I S + G Y C A + AG + V
Sbjct: 2578 LPNGTDLQSGQ----QLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
Query: 397 TDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLAD 452
P N V++ GET L C G +W + P + GRV+ L +
Sbjct: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
Query: 453 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ--VSIHTSSQHFSQGVEVKV 510
+L + D G Y C G + S+ ++V P S T + G VK+
Sbjct: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKL 2753
Query: 511 SCSASGYPTPHISWSRESQALQE---DSRIH----VDAQGTLIIQGVAPEDAGNYSCQAT 563
+C A G P I+W ++ + +R++ + QG+L IQ DAG Y C A
Sbjct: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
Query: 564 NEVGTDQETVTLY 576
N +G+D +T ++
Sbjct: 2814 NILGSDSKTTYIH 2826
Score = 65.1 bits (157), Expect = 4e-10
Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 12/208 (5%)
Query: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVL 440
+S T +A+ + V P V TV G LSC V ++ WV D +L
Sbjct: 463 ISTKDTRQARGRSWVMIEPSGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
Query: 441 PAST----GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 496
A + + L+ L I + P+D G YQC+A + + R +LV+
Sbjct: 522 KAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE 581
Query: 497 TSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLIIQGV 550
+ + G V + C+A P H+SW ++ + D S +++ GTL I V
Sbjct: 582 KDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKV 641
Query: 551 APEDAGNYSCQATNEVGTDQETVTLYYT 578
D+G Y C A N+ G D TV + T
Sbjct: 642 QVSDSGYYRCVAVNQQGADHFTVGITVT 669
Score = 60.8 bits (146), Expect = 7e-09
Identities = 48/201 (23%), Positives = 80/201 (39%), Gaps = 17/201 (8%)
Query: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
Q +++ R W+++ + V Q +G ++SC+ +P I W
Sbjct: 461 QTISTKDTRQARGRSWVMIEPSGAVQ---RDQTVLEGGPCQLSCNVKASESPSIFWVLPD 517
Query: 529 QALQE------DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
++ + DS+ + + G L I+ + P D+G Y C A D+ + P +
Sbjct: 518 GSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST 577
Query: 583 VSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLR 634
A V + GE L C A +P + W +I +S +G L
Sbjct: 578 QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLS 637
Query: 635 IPAAQERDAGTYTCRAVNELG 655
IP Q D+G Y C AVN+ G
Sbjct: 638 IPKVQVSDSGYYRCVAVNQQG 658
Score = 60.8 bits (146), Expect = 7e-09
Identities = 53/183 (28%), Positives = 72/183 (39%), Gaps = 14/183 (7%)
Query: 779 VLEGQPVSLPCIVLAGRPLPERHW-LKDGRPLP-----PGSRHSIRADGSLHLDRALQEH 832
VLEG P L C V A P W L DG L P S+ SI + G L +
Sbjct: 491 VLEGGPCQLSCNVKASES-PSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
Query: 833 AGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHIT---NEGVPASLPCVASGVPAPT 889
+G Y C+A R V V+ P P +T N G +LPC A +P
Sbjct: 550 SGLYQCIA-QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
Query: 890 ITWTKETNALTS---RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
++W + + H + GTL I + D+G Y C A N G + ++V
Sbjct: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
Query: 947 NTK 949
K
Sbjct: 669 TKK 671
Score = 60.8 bits (146), Expect = 7e-09
Identities = 46/175 (26%), Positives = 71/175 (40%), Gaps = 19/175 (10%)
Query: 872 EGVPASLPCVASGVPAPTITWTKETNALTSR-----GPHYNVSKEGTLLIAQPSAQDAGA 926
EG P L C +P+I W ++ +++ G L I D+G
Sbjct: 493 EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
Query: 927 YVCTATNTVGFSSQEMRLSV---NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGS 983
Y C A R+ V +T+P + + GE VTL C A
Sbjct: 553 YQCIAQVRDEMDRMVYRVLVQSPSTQPA--------EKDTVTIGKNPGESVTLPCNALAI 604
Query: 984 PPPLVTWTKDSRPVP---PITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
P ++W +R + T+ +LP+G+L + +VQV DSG+Y C A N G+
Sbjct: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
Score = 56.6 bits (135), Expect = 1e-07
Identities = 51/186 (27%), Positives = 76/186 (40%), Gaps = 10/186 (5%)
Query: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV 735
RD TV G L+C P++ W DG L + S+ SG L +S+
Sbjct: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD-DPDSKFSILSSGWLRIKSM 545
Query: 736 APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 795
P D Y C A+ + R++V + T+ G+ V+LPC LA
Sbjct: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA-- 603
Query: 796 PLPERH--WLKDGR----PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 849
+PE H W+ R L S + +G+L + + +G Y CVA N G+ H
Sbjct: 604 -IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHF 662
Query: 850 DVELVV 855
V + V
Sbjct: 663 TVGITV 668
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 361 NSSWEILRASK-AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETA 417
+S W +++ + ++ G Y+C A R R +++V P Q VT+ +PGE+
Sbjct: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
Query: 418 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
L C L +L+W+ R + A+T V L + +L I + +D G Y+CVA N
Sbjct: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
Query: 475 ANGVTRASVWLLV 487
G +V + V
Sbjct: 656 QQGADHFTVGITV 668
Score = 47.8 bits (112), Expect = 6e-05
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV--PAPNVTVSPGETAV 418
N + + AS + GTY C + G ++V PP++ P P + PG T
Sbjct: 2693 NGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVK 2752
Query: 419 LSCRVLGEAPYNLTW-VRDWRVLPAST-----GRVAQLADLSLEISGIIPTDGGRYQCVA 472
L+C +G ++TW + D L A G SL I D G Y+C+A
Sbjct: 2753 LNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMA 2812
Query: 473 SNANGVTRASVWLLV 487
N G + ++ V
Sbjct: 2813 KNILGSDSKTTYIHV 2827
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 228 bits (580), Expect = 3e-59
Identities = 188/747 (25%), Positives = 302/747 (40%), Gaps = 51/747 (6%)
Query: 321 GYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEE---GTY 377
G L ++ C V + P + + ++ +Q + + + L+ + + G Y
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNY 5870
Query: 378 ECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 437
C A + AG+ +A + V +PP + + V PG+ + + G P+ + W R
Sbjct: 5871 TCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA 5930
Query: 438 RVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 495
R L D LE+ I + G Y CV SN G + L V+E
Sbjct: 5931 RELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLK 5990
Query: 496 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH-VDAQGTLIIQ--GVAP 552
S G + + + +G ++W ++ + + + V + T I++
Sbjct: 5991 RLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTK 6050
Query: 553 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 612
DAG YSC+ NE G D + +PP + AVG+ L C+ +G P V
Sbjct: 6051 RDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITV 6110
Query: 613 IWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 667
WY+G ++ PE ++ L D+G YTC+A N +G AS++ +
Sbjct: 6111 SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQE 6170
Query: 668 ---APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
P +D+ +G L CR G P V W R G+ L ++
Sbjct: 6171 RQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRD-----GVLLRDDENLQTSF 6225
Query: 725 PDS-GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP---PQIASSAPTVRVL 780
D+ L Y C A N G + ARL T P P ++ V+
Sbjct: 6226 VDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARL--TAREPKKSPFFDIKPVSIDVI 6283
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYS 837
G+ C V +P+ W KD + + PG ++I G+ L + + + +G+Y+
Sbjct: 6284 AGESADFECHVTGAQPM-RITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYT 6342
Query: 838 CVATNTAGSQHRDVELVVQVPPR-IHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
C ATN G +L V+ PP+ + + +G L C SG P ++W +
Sbjct: 6343 CQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRND 6402
Query: 897 NALTSRGPHYNVS---KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIH 953
+ L YN+S L I + SA+D+G Y+C A N VG +S L+V P
Sbjct: 6403 SEL-HESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVF- 6460
Query: 954 MNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP-----PITNRYGLLP 1008
P V A G +V L CE G+PP V W KD + V IT+++
Sbjct: 6461 ------TQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHF--- 6511
Query: 1009 SGSLRLAQVQVGDSGHYECTASNPAGS 1035
SL + ++ D G Y C A+N GS
Sbjct: 6512 DTSLHILNLEASDVGEYHCKATNEVGS 6538
Score = 221 bits (563), Expect = 3e-57
Identities = 191/734 (26%), Positives = 292/734 (39%), Gaps = 40/734 (5%)
Query: 329 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAE---EGTYECTAVSRA 385
+ C V + P +Q + + + ++ S + + L S+ E GTY C+A ++A
Sbjct: 4694 LECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKA 4753
Query: 386 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 445
G + + V +PP + + V+P L V G AP + W +D + L +
Sbjct: 4754 GHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAA 4813
Query: 446 RVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHF 502
R D S LE+ TD G Y C SN G + L V+E PQ + +
Sbjct: 4814 RSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVL 4873
Query: 503 SQGVEVKVSCSASGYPTPHISW---SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559
G C +G P +SW E A+Q+ +D T I G E++G Y
Sbjct: 4874 RNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYV 4933
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
C+A N+ GT ++ L +PP+ V V + L CE +G PP V W +
Sbjct: 4934 CEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNR 4993
Query: 620 EMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL 674
E+ + + + + + L I D G Y C NE G S ++A+ P +
Sbjct: 4994 EIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKK 5053
Query: 675 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS-GVLFFE 733
+ T L SA G PP ++TW + D L DS L
Sbjct: 5054 IENTTTVLKSSATFQSTVAGSPPISITWLKDD-----QILDEDDNVYISFVDSVATLQIR 5108
Query: 734 SVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLA 793
SV Y C+A+N G + A L+V P QI A +V V E P++L C+V A
Sbjct: 5109 SVDNGHSGRYTCQAKNESGVERCYAFLLV--QEPAQIVEKAKSVDVTEKDPMTLECVV-A 5165
Query: 794 GRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRALQEHAGRYSCVATNTAGSQHRD 850
G P + WLKDG+ + P S+ + S + +++ +G+Y+ N GS D
Sbjct: 5166 GTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCD 5225
Query: 851 VELVV---QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN 907
L V +PP T G + C SG + W K+ +++ +
Sbjct: 5226 AYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRL 5285
Query: 908 VSKEG--TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ 965
V E +L + +D Y C +N G + L+V P + R +P
Sbjct: 5286 VCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIP-- 5343
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY-GLLPSGS-LRLAQVQVGDSG 1023
V KG+PP + W KD + + GL S S L L V +G
Sbjct: 5344 -----DSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTG 5398
Query: 1024 HYECTASNPAGSAS 1037
Y C +N GS S
Sbjct: 5399 QYTCHVTNDVGSDS 5412
Score = 217 bits (552), Expect = 6e-56
Identities = 209/794 (26%), Positives = 322/794 (40%), Gaps = 50/794 (6%)
Query: 298 VSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ 357
V G S + P + + P + + + + C V + +G+ +L ++
Sbjct: 6068 VCGALVSTLEPPYFVTELEP-LEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYR 6126
Query: 358 ESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTV 411
++ L +K + G Y C A + GT +K + + PP ++
Sbjct: 6127 TYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQ 6186
Query: 412 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTD---GGRY 468
+ G L+CR+ G AP + W RD +L D ++ I+ TD G+Y
Sbjct: 6187 TVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVD-NVATLKILQTDLSHSGQY 6245
Query: 469 QCVASNANGVTRASVWLLVRE---APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS 525
C ASN G +S L RE +P I S G C +G I+WS
Sbjct: 6246 SCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWS 6305
Query: 526 RESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
++++ ++ + G L I V D+G Y+CQATN+VG D + L +PP
Sbjct: 6306 KDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPK 6365
Query: 583 -VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIP 636
V + A + GE L C+ SG P +V W+R E+ + + + S L I
Sbjct: 6366 FVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTIN 6425
Query: 637 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 696
A D+G Y C A N +GDAS L V P T+ P V G +L C +G P
Sbjct: 6426 EASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTP 6485
Query: 697 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQA 756
P V W + Q +R S+ D+ L ++ D Y C+A N G
Sbjct: 6486 PFEVVWVKDRKQ---VRNSKKFKITSKHFDTS-LHILNLEASDVGEYHCKATNEVGSDTC 6541
Query: 757 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 816
V PP+ L G V L IV +P+ WLKD + S ++
Sbjct: 6542 SCS--VKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI-SVVWLKDRGEVIRESENT 6598
Query: 817 ----IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNE 872
I +L L ++G+Y C N AG + L V P RI
Sbjct: 6599 RISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTT 6658
Query: 873 GVPASLPCVASGVPAPTITWTKETNALTSRGPHY--NVSKEGTLLIAQPSAQDAGAYVCT 930
G P +L CV +G P + W K+ L++ H+ ++K +L I D G Y
Sbjct: 6659 GNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFE 6718
Query: 931 ATNTVGFSSQEMRLSVNTK--PRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988
N+VG S+ + + V+ + P + ++ N L G V L+C GS P V
Sbjct: 6719 VKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL------GASVVLECRVSGSAPISV 6772
Query: 989 TWTKDSRPV---PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
W +D + P + + +L L+ ++ D+G Y C A+N AGS VL VQ
Sbjct: 6773 GWFQDGNEIVSGPKCQSSFSENVC-TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQ 6831
Query: 1046 GRTSWQ--PQSLPV 1057
S++ P S+ V
Sbjct: 6832 EPPSFEQTPDSVEV 6845
Score = 216 bits (550), Expect = 1e-55
Identities = 185/700 (26%), Positives = 279/700 (39%), Gaps = 34/700 (4%)
Query: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTVSPGETAV 418
S +I+ + ++ G Y + G A + V+D PP G + V
Sbjct: 7641 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVV 7700
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNAN 476
+ C+V G P +++W + + + L D +L ++ + +D G Y C+A+N
Sbjct: 7701 MECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMA 7760
Query: 477 GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 536
G S L VRE P G V + G P +SW + S L R
Sbjct: 7761 GSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDR 7820
Query: 537 IHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
+V D+ L + V +G Y+C +NE G T LY P +
Sbjct: 7821 CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIE 7880
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTC 648
G+ +L +G PP V W + G+ + + + S L IP++ DAG Y C
Sbjct: 7881 KGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNC 7940
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
N G S Q+ + P + V V +G SA L C+ G P V+W +GD +
Sbjct: 7941 YIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTK 8000
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH-AP 767
LR R + L F V D Y+C+A N G+V A L V P
Sbjct: 8001 ---LRPTTTYKMHFRN-NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLP 8056
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL---PPGSRHSIRADGSLH 824
P + V+ G PV C + P+ W KDG+PL P + +L+
Sbjct: 8057 PSFSRQLRDVQETVGLPVVFDCAISGSEPI-SVSWYKDGKPLKDSPNVQTSFLDNTATLN 8115
Query: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVV---QVPPRIHPTATHHITNEGVPASLPCV 881
+ + + AG+YSC ATN GS L++ + PP G A C
Sbjct: 8116 IFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECH 8175
Query: 882 ASGVPAPTITWTKETNALTSRGPHYNVS---KEGTLLIAQPSAQDAGAYVCTATNTVGFS 938
+G ++W K++ + S G Y +S L + + D+G Y C A N VG
Sbjct: 8176 VTGTQPIKVSWAKDSREIRS-GGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKD 8234
Query: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
S +L N K R+ + S + V G L+ GS P V W K++ +
Sbjct: 8235 SCTAQL--NIKERL-IPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQ 8291
Query: 999 PITNRYGLLPSGSLRLAQVQVG--DSGHYECTASNPAGSA 1036
P +N + +L L + G D+G Y C SN AGSA
Sbjct: 8292 PTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSA 8331
Score = 210 bits (535), Expect = 6e-54
Identities = 181/713 (25%), Positives = 280/713 (39%), Gaps = 47/713 (6%)
Query: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
EIL ++ + Y C + AG +A + V +PP + P +V GE A L C+V
Sbjct: 6985 EILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVD 7044
Query: 425 GEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRAS 482
G ++W ++ L ++ Q + SL I+ + +D G Y C A N+ G +S
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASS 7104
Query: 483 VWLLVRE---APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH- 538
L+++ P + H + G V C +G +SW ++ L++D+ +
Sbjct: 7105 AVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQT 7164
Query: 539 --VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVA 593
V TL I G Y+C A+N +GT + L ++ PP V +A
Sbjct: 7165 SFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLA 7224
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-------SSGKLRIPAAQERDAGTY 646
+GE C +G P ++ W + E + P G+ ++ L + + DAG Y
Sbjct: 7225 LGESGTFKCHVTGTAPIKITWAKDNRE--IRPGGNYKMTLVENTATLTVLKVGKGDAGQY 7282
Query: 647 TCRAVNELGDASAEIQLAVGHAPQ-LTELPRDVTVELGRSALLACRATGRPPPTVTWRRG 705
TC A N G S QL V P+ + +L V+ C+ G P V W +
Sbjct: 7283 TCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKD 7342
Query: 706 DGQPLGLRLGAGRGSRSRQPDS-GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 764
+ + + R DS VL +++ ED Y CEA N G + L V
Sbjct: 7343 ETE-----IQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV-- 7395
Query: 765 HAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG--- 821
PP + L+G V L C L G P W KD R L G ++ I ++
Sbjct: 7396 KEPPIFRKKPHPIETLKGADVHLEC-ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLT 7454
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCV 881
S+H+ G Y C ATN GS + ++ PPR + T G L
Sbjct: 7455 SIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTT 7514
Query: 882 ASGVPAPTITWTKETNALTSRGPHYNVSKE---GTLLIAQPSAQDAGAYVCTATNTVGFS 938
G ++ W K+ + + +S TL ++ +AG Y C N G
Sbjct: 7515 IEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQ 7574
Query: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
LSV + + P + G+ TL+C G+P W KD + +
Sbjct: 7575 ECFATLSV-------LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELT 7627
Query: 999 PITNRYGLL---PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT 1048
N+Y + L++ V DSG Y NP G S L V RT
Sbjct: 7628 S-DNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRT 7679
Score = 209 bits (532), Expect = 1e-53
Identities = 205/771 (26%), Positives = 315/771 (40%), Gaps = 57/771 (7%)
Query: 330 SCSVHSALPFRLQLRRGEARLGEERHFQESGN---SSWEILRASKAEEGTYECTAVSRAG 386
+C + SA R Q + + E + SS EILR + G Y C A + G
Sbjct: 3476 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 3535
Query: 387 TGRAKAQIVVTD--PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PAS 443
+ A + VT+ PP L ++T G+ A C V G W +D L P+
Sbjct: 3536 SVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSP 3595
Query: 444 TGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 502
R++ + LE+S + D G Y C ASN G L++ + P
Sbjct: 3596 NWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQS 3655
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQ--EDSRI-HVDAQGTLIIQGVAPEDAGNYS 559
+ +V + C ++WS++ Q L +D +I D TL I +D+G Y
Sbjct: 3656 AINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 560 CQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
C A+NE G+ + T+ +PPS V V+ L+ GE A L C+ G P +V W++
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNN 3775
Query: 619 LEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 673
E+ + +S L I + D+G+Y+C AVN++G S ++ + P +
Sbjct: 3776 KELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIK 3835
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV-LFF 732
+ G +ALL C +G P ++W + Q + + + R S V L
Sbjct: 3836 TLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQ-----IRSSKKYRLFSQKSLVCLEI 3890
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVL 792
S D Y C N GK A ++ PP + L GQ V+L V
Sbjct: 3891 FSFNSADVGEYECVVANEVGKCGCMATHLL--KEPPTFVKKVDDLIALGGQTVTLQAAVR 3948
Query: 793 AGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-----------RALQEHAGRYSCVAT 841
P+ W+K + IR DG + + G+Y+C+A
Sbjct: 3949 GSEPISVT-WMK--------GQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAE 3999
Query: 842 NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 901
N AGSQ EL+V+ P +I A G PA+L +G P W K+ L +
Sbjct: 4000 NEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVA 4059
Query: 902 RGPHYNVSKEGTLLIAQPSAQ--DAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
+ K + SA+ D+G Y +N VG SS E +V +
Sbjct: 4060 SKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPL 4119
Query: 960 ANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL---PSGSLRLAQ 1016
NV V LDC+ GS P V+W KD + + ++RY + + SL + +
Sbjct: 4120 RNVDSVVNGTC----RLDCKIAGSLPMRVSWFKDGKEI-AASDRYRIAFVEGTASLEIIR 4174
Query: 1017 VQVGDSGHYECTASNPAGSASHRYVLGVQGRTSW--QPQSLPV-PHHPACL 1064
V + D+G++ C A+N GS L VQ S+ +P S V P CL
Sbjct: 4175 VDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL 4225
Score = 207 bits (526), Expect = 6e-53
Identities = 195/744 (26%), Positives = 297/744 (39%), Gaps = 46/744 (6%)
Query: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTVSPGETAV 418
+S +I A +++G Y + G + V+D PP + +V G + V
Sbjct: 6700 ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVV 6759
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNAN 476
L CRV G AP ++ W +D + + + ++ +L +S + P+D G Y CVA+N
Sbjct: 6760 LECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVA 6819
Query: 477 GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 536
G S L V+E P S G+ + + G P + W + S+ L
Sbjct: 6820 GSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGES 6879
Query: 537 IHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
++ + L + V P ++G+YSC TN+ G+ T L+ +P + A V
Sbjct: 6880 CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVE 6939
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTC 648
G VL +G PP V W + + + S S L I + D Y+C
Sbjct: 6940 TGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSC 6999
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
NE G E ++V P E V +G A L C+ G P ++W + +
Sbjct: 7000 LIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYK---E 7056
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA-P 767
LR + + + L V D Y C+A N G V + A L++ P
Sbjct: 7057 HTKLRSAPAYKMQFKN-NVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLP 7115
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS---IRADGSLH 824
P A V G PV+ C + PL + W KDG L + + +L
Sbjct: 7116 PFFARKLKDVHETLGFPVAFECRINGSEPL-QVSWYKDGVLLKDDANLQTSFVHNVATLQ 7174
Query: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVV---QVPPRIHPTATHHITNEGVPASLPCV 881
+ + Q H G+Y+C A+N G+ +L++ +VPP G + C
Sbjct: 7175 ILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCH 7234
Query: 882 ASGVPAPTITWTKETNALTSRGPHYN--VSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
+G ITW K+ + G + V TL + + DAG Y C A+N G S
Sbjct: 7235 VTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDS 7294
Query: 940 QEMRLSVNTKPRI--HMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
+L V PR + SR K E +C+ GSP V W KD +
Sbjct: 7295 CSAQLGVQEPPRFIKKLEPSR--------IVKQDEFTRYECKIGGSPEIKVLWYKDETEI 7346
Query: 998 PPITN-RYGLLPSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSL 1055
+ R + S + L + + V DSG Y C A N AGSAS L V+ ++ +
Sbjct: 7347 QESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKK-- 7404
Query: 1056 PVPHHPACLSGLSVPL---LQPTP 1076
PH L G V L LQ TP
Sbjct: 7405 --PHPIETLKGADVHLECELQGTP 7426
Score = 207 bits (526), Expect = 6e-53
Identities = 188/776 (24%), Positives = 305/776 (39%), Gaps = 67/776 (8%)
Query: 320 HGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEE---GT 376
+G +++ C V+ + P + + R +Q + + L + EE G
Sbjct: 7692 NGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGD 7751
Query: 377 YECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD 436
Y C A + AG+ A + V +PP + + V G + V G P++++W +
Sbjct: 7752 YTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKG 7811
Query: 437 WRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 494
L L D LE+ + + G Y C+ SN G + L ++ +
Sbjct: 7812 SSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFV 7871
Query: 495 IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVA 551
+ +G + + + +G P ++W + + R ++ + L I
Sbjct: 7872 KRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSST 7931
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 611
EDAG Y+C N G D + + +PP V V+VG+ A L C+ +G P
Sbjct: 7932 VEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIG 7991
Query: 612 VIWYRGGLEMILAPEGSSSGKLRIPAA-------QERDAGTYTCRAVNELGDASAEIQLA 664
V WY+G + L P + R A D+G Y C+A N +G+ SA L
Sbjct: 7992 VSWYKGDTK--LRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLT 8049
Query: 665 VGHA---PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR 721
V P + RDV +G + C +G P +V+W + DG+PL
Sbjct: 8050 VQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYK-DGKPL----------- 8097
Query: 722 SRQPDSGVLFFESVAPED--------QAPYVCEARNVFGKVQAEARLIVT-GHAPPQIAS 772
P+ F ++ A + Y C A N G + ARLI+T G PP
Sbjct: 8098 KDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDI 8157
Query: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR-ADGSLHLD--RAL 829
V + G+ C V +P+ + W KD R + G ++ I + S HL +
Sbjct: 8158 RLAPVDAVVGESADFECHVTGTQPI-KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVD 8216
Query: 830 QEHAGRYSCVATNTAGSQHRDVELVVQ---VPPRIHPTATHHITN-EGVPASLPCVASGV 885
+ +G+Y+C A N G +L ++ +PP + + EG L +G
Sbjct: 8217 KGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS 8276
Query: 886 PAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSA--QDAGAYVCTATNTVGFS--SQE 941
T+ W K + K TL++ A DAG Y C +N G + +
Sbjct: 8277 QPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSS 8336
Query: 942 MRLSVNTKPRI---HMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
+ + KP + H+ VT GE V L C +GS P + W K R +
Sbjct: 8337 IVIKEPKKPPVFDQHLT---------PVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIK 8387
Query: 999 PITNRYGLLPSGS--LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
P SG+ L L V DSG Y C ASN AGS + + + ++ + + P
Sbjct: 8388 PSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAP 8443
Score = 206 bits (525), Expect = 8e-53
Identities = 192/779 (24%), Positives = 306/779 (39%), Gaps = 46/779 (5%)
Query: 310 APLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEI 366
A +V A + P+ + C V +++ + ++ R+F E+ +S+ I
Sbjct: 5141 AQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRI 5200
Query: 367 LRASKAEEGTYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTVSPGETAVLSCRV 423
K + G Y + G+ A + V D PP + G + + C+V
Sbjct: 5201 QSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260
Query: 424 LGEAPYNLTWVRDWRVLPASTGR--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 481
G P + W +D + + S V +SLE++ + D Y C SN G
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDAC 5320
Query: 482 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541
S L V+E P + Q V+ G P I W ++ L + +
Sbjct: 5321 SGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGL 5380
Query: 542 QGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEE 597
+G+ L + V G Y+C TN+VG+D T L T+PP V + A +V G+
Sbjct: 5381 EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDS 5440
Query: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVN 652
+ L C+ +G P RV+W+R E+ + + S +++ D+G + C A N
Sbjct: 5441 SRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQN 5500
Query: 653 ELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
G S ++ V P + P V L C +G PP V W + Q L
Sbjct: 5501 PAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQ---L 5557
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 772
R S+ + + +V D Y C+A+N G + + PP+ S
Sbjct: 5558 RSSKKYKIASKNFHTSIHIL-NVDTSDIGEYHCKAQNEVGSDTCVCTVKLK--EPPRFVS 5614
Query: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS----IRADGSLHLDRA 828
++ V+ G+P L + +P+ + WLK+ + S + + +L +A
Sbjct: 5615 KLNSLTVVAGEPAELQASIEGAQPIFVQ-WLKEKEEVIRESENIRITFVENVATLQFAKA 5673
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
+AG+Y C N G + L+V P I A G +L C +G P
Sbjct: 5674 EPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPEL 5733
Query: 889 TITWTKETNALTSRGPH----YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
++ W K+ LTS H YN K +L I QDAG Y N VG SS +
Sbjct: 5734 SVEWYKDGKLLTSSQKHKFSFYN--KISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVV 5791
Query: 945 SVNTK--PRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITN 1002
V+ + P +N L G L+C+ GS P V W + +
Sbjct: 5792 DVSDRAVPPSFTRRLKNTGGVL------GASCILECKVAGSSPISVAWFHEKTKIVSGAK 5845
Query: 1003 RYGLLPSG--SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSW--QPQSLPV 1057
+L+L + D G+Y C A+N AGS R VL VQ S+ +P+ L V
Sbjct: 5846 YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEV 5904
Score = 202 bits (514), Expect = 2e-51
Identities = 182/763 (23%), Positives = 316/763 (41%), Gaps = 58/763 (7%)
Query: 329 VSCSVHSALPFRLQ-LRRGEARLGEERH---FQESGNSSWEILRASKAEEGTYECTAVSR 384
+ C + +LP R+ + G+ +R+ F E G +S EI+R + G + C A +
Sbjct: 4132 LDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE-GTASLEIIRVDMNDAGNFTCRATNS 4190
Query: 385 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA-- 442
G+ + ++V +PP + + V PG L G P + W + + L +
Sbjct: 4191 VGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGG 4250
Query: 443 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE-APQVSIHTSSQH 501
S + + SLE+ + +D G Y C SN G S L V+E A V SQ
Sbjct: 4251 SCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQL 4310
Query: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNY 558
+G +++C +G P I+W + ++E S+ V++ L + V ED+G Y
Sbjct: 4311 LKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370
Query: 559 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
C+A NE G+D + + + P + + V + +L+ E +G PP + W++
Sbjct: 4371 MCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDN 4430
Query: 619 --------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ 670
+ + S L+ AA DAG Y CR NE+G + ++ + P
Sbjct: 4431 TILRSGRKYKTFIQDHLVSLQILKFVAA---DAGEYQCRVTNEVGSSICSARVTLREPPS 4487
Query: 671 LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL---GLRLGAGRGSRSRQPDS 727
+ + G +A G P TVTW + + +R+ + + +
Sbjct: 4488 FIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRM-------TFENNV 4540
Query: 728 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
L+ + + YVC+A+N G + A L V P I A ++ V +G P +L
Sbjct: 4541 ASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSV--KEPATITEEAVSIDVTQGDPATL 4598
Query: 788 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL---QEHAGRYSCVATNTA 844
+ +G W KDG+ L GS++ I ++ + + + ++ +G Y+ N
Sbjct: 4599 Q-VKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDV 4657
Query: 845 GSQHRDVELVVQ---VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 901
G + V +PP + +G L C+ +G +I W K+ +++
Sbjct: 4658 GRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISA 4717
Query: 902 RGPHYNVSKEGT--LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRI---HMNG 956
+ + T L I+Q D+G Y C+ATN G + L+V P +
Sbjct: 4718 SEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQ 4777
Query: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR--YGLLPSGSLRL 1014
N N +Q+ A G G+ P + W KD++ + R + S SL L
Sbjct: 4778 DVNPNTRVQLKALVG----------GTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLEL 4827
Query: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPV 1057
+ DSG Y C SN G+A+ + L V+ + + PV
Sbjct: 4828 FAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPV 4870
Score = 201 bits (512), Expect = 3e-51
Identities = 179/742 (24%), Positives = 294/742 (39%), Gaps = 44/742 (5%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA---SKAEEGTYECTAVSRAGT 387
C + + ++ + E + E F+ S S +L S + G Y C A + AG+
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386
Query: 388 GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV 447
+ + V +PP + G L C + G P++++W +D R L +G+
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKREL--RSGKK 7444
Query: 448 AQLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 503
++ S+ I + D G YQC A+N G + ++ P+ S
Sbjct: 7445 YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTV 7504
Query: 504 QGVEVKVSCSASGYPTPHISWSRES-QALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYS 559
G EV++ + G + W ++ + ++E I + TL V P +AG Y+
Sbjct: 7505 VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
CQ N+ G + TL +P ++ + V G+ L C +G P W++ G
Sbjct: 7565 CQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGK 7624
Query: 620 EMILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH---APQL 671
E+ + S L+I D+G Y+ N +G S L V P
Sbjct: 7625 ELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSF 7684
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-VL 730
T ++ G S ++ C+ G PP +V+W G + +GR ++ D+ L
Sbjct: 7685 TRKLKETNGLSGSSVVMECKVYGSPPISVSWFHE-----GNEISSGRKYQTTLTDNTCAL 7739
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
+ D Y C A N+ G + A L V PP + VL G V+ I
Sbjct: 7740 TVNMLEESDSGDYTCIATNMAGSDECSAPLTV--REPPSFVQKPDPMDVLTGTNVTFTSI 7797
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQ 847
V G P W K L PG R ++ + S L L +G Y+C+ +N AG
Sbjct: 7798 V-KGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKA 7856
Query: 848 HRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE-TNALTSRGPHY 906
L ++ P + + +G P L +G P ++TW K N S+ +
Sbjct: 7857 SCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNI 7916
Query: 907 NVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ 965
+++ +L I + +DAG Y C N G S ++ + P P++
Sbjct: 7917 TTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLE-----PVK 7971
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT--NRYGLLPSGSLRLAQVQVGDSG 1023
V+ G+ +L C+ G+P V+W K + P T + +L QV + DSG
Sbjct: 7972 VS--VGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSG 8029
Query: 1024 HYECTASNPAGSASHRYVLGVQ 1045
Y C A N G S L VQ
Sbjct: 8030 EYICKAENSVGEVSASTFLTVQ 8051
Score = 201 bits (511), Expect = 4e-51
Identities = 183/705 (25%), Positives = 281/705 (39%), Gaps = 44/705 (6%)
Query: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411
E +H E N + + + G Y C A ++ G +A++++ D P + V
Sbjct: 3603 ENKHILELSNLTIQ-------DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQS 3655
Query: 412 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQ 469
+ + L C+V + +TW +D + LP D +LEI D G Y
Sbjct: 3656 AINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 470 CVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
C ASN G + S + VRE P V S G ++ C G P ++W + +
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNN 3775
Query: 529 QALQEDSRIH---VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSA 585
+ L E + + V+++ L I V ED+G+YSC+A N+VG+D + + +PPS
Sbjct: 3776 KELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIK 3835
Query: 586 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQE 640
+ G A+L CE SG P + W++ ++ + + S L I +
Sbjct: 3836 TLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNS 3895
Query: 641 RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV 700
D G Y C NE+G + P + D+ G++ L G P +V
Sbjct: 3896 ADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISV 3955
Query: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
TW +G + G+ S VL V Y C A N G + L
Sbjct: 3956 TWMKGQ----EVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGEL 4011
Query: 761 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
IV P +I A ++V G P +L V AG P + W KDGRPL ++ I
Sbjct: 4012 IV--KEPAKIIERAELIQVTAGDPATLEYTV-AGTPELKPKWYKDGRPLVASKKYRISFK 4068
Query: 821 GS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPAS 877
+ L A +G+Y+ +N GS + V + I P T + N +
Sbjct: 4069 NNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTV-LDRDIAPFFTKPLRNVDSVVN 4127
Query: 878 ----LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT--LLIAQPSAQDAGAYVCTA 931
L C +G ++W K+ + + + EGT L I + DAG + C A
Sbjct: 4128 GTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRA 4187
Query: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT 991
TN+VG L V P +P G V L +GS P + W
Sbjct: 4188 TNSVGSKDSSGALIVQEPPSFVTKPGSKDVLP-------GSAVCLKSTFQGSTPLTIRWF 4240
Query: 992 KDSRPVPPITNRYGLLPS--GSLRLAQVQVGDSGHYECTASNPAG 1034
K ++ + + Y + SL L V+ DSG Y C SN AG
Sbjct: 4241 KGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAG 4285
Score = 200 bits (508), Expect = 8e-51
Identities = 179/722 (24%), Positives = 292/722 (40%), Gaps = 34/722 (4%)
Query: 357 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGE 415
+E+ SS E+ ++ GTY C + AG A + V +P + P+ + G+
Sbjct: 4256 KEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGD 4315
Query: 416 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVAS 473
L+C+V G P +TW + R + S+ + + L ++ + D G Y C A
Sbjct: 4316 ATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQ 4375
Query: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE 533
N G S ++V+E+P + + +V + +G P I+W +++ L+
Sbjct: 4376 NEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRS 4435
Query: 534 DSRIHVDAQGTLI---IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV 590
+ Q L+ I DAG Y C+ TNEVG+ + + +PPS
Sbjct: 4436 GRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIEST 4495
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGT 645
G A G P V W + E+ I ++ L + + + G
Sbjct: 4496 SSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGK 4555
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRG 705
Y C+A N+ G L+V +TE + V G A L + +G T W +
Sbjct: 4556 YVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFK- 4614
Query: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 765
DGQ L L + S +L S +D Y E +N G+ +AR+ V
Sbjct: 4615 DGQELTL---GSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDL 4671
Query: 766 A-PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS-- 822
PP + ++G + L CIV P+ + W KD + + ++ +
Sbjct: 4672 IIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQ-WFKDDQEISASEKYKFSFHDNTA 4730
Query: 823 -LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCV 881
L + + +G Y+C ATN AG L V+ PP N L +
Sbjct: 4731 FLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKAL 4790
Query: 882 ASGVPAPTITWTKETNALTSRGPHYNVSKEGT---LLIAQPSAQDAGAYVCTATNTVGFS 938
G TI W K+ L S G +V K+ T L + A D+G Y+C +N VG +
Sbjct: 4791 VGGTAPMTIKWFKDNKELHS-GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTA 4849
Query: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
+ + L V P+ S P+ V + G+ T +C+ G+P V+W D +
Sbjct: 4850 TSKATLFVKEPPQFIKKPS-----PVLVL-RNGQSTTFECQITGTPKIRVSWYLDGNEIT 4903
Query: 999 PITNRYGLLPSGSLRLAQV---QVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSL 1055
I ++G+ L Q+ +V +SG Y C A N AG+AS L V+ ++ +
Sbjct: 4904 AI-QKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELK 4962
Query: 1056 PV 1057
PV
Sbjct: 4963 PV 4964
Score = 198 bits (503), Expect = 3e-50
Identities = 183/727 (25%), Positives = 284/727 (39%), Gaps = 46/727 (6%)
Query: 338 PFRLQLRRGEARL--GEERHFQ-ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
PF+++ +G L GE + E + E+ E G Y C + AG+ +
Sbjct: 6862 PFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHL 6921
Query: 395 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 454
V +P + + +V G VL G P +++W++D ++ S + + S
Sbjct: 6922 FVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKS 6981
Query: 455 --LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 512
LEI D +Y C+ N G + V E P G + C
Sbjct: 6982 TILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQC 7041
Query: 513 SASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATNEVGTD 569
G P ISW +E L+ + + +L+I V D G YSC+A N VG
Sbjct: 7042 KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAV 7101
Query: 570 QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE 626
+ L PP + V +G C +G P +V WY+ G ++L +
Sbjct: 7102 ASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG--VLLKDD 7159
Query: 627 GS-------SSGKLRIPAAQERDAGTYTCRAVNELGDA--SAEIQLAVGHAPQLTEL-PR 676
+ + L+I + G Y C A N LG A SA++ L+ P +L P
Sbjct: 7160 ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPV 7219
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
V + LG S C TG P +TW + + + +R G G + ++ L V
Sbjct: 7220 SVDLALGESGTFKCHVTGTAPIKITWAKDNRE---IRPG-GNYKMTLVENTATLTVLKVG 7275
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796
D Y C A N+ GK A+L V PP+ R+++ + + G P
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGV--QEPPRFIKKLEPSRIVKQDEFTRYECKIGGSP 7333
Query: 797 LPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVEL 853
+ W KD + S+ + S L + E +G Y+C A N AGS L
Sbjct: 7334 EIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSL 7393
Query: 854 VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT 913
V+ PP T +G L C G P ++W K+ L S G Y + E
Sbjct: 7394 KVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRS-GKKYKIMSENF 7452
Query: 914 LL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
L I A D G Y C ATN VG + +++ PR S ++
Sbjct: 7453 LTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLS-------DISTVV 7505
Query: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS---GSLRLAQVQVGDSGHYEC 1027
G+EV L +G+ P V W KD + ++ + S +L+ ++V+ ++G Y C
Sbjct: 7506 GKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTC 7565
Query: 1028 TASNPAG 1034
N AG
Sbjct: 7566 QIKNDAG 7572
Score = 195 bits (496), Expect = 2e-49
Identities = 180/700 (25%), Positives = 274/700 (39%), Gaps = 40/700 (5%)
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 431
+ G Y C + AG A + V +P + +TV+ G L C V G +
Sbjct: 6617 SNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSA 6676
Query: 432 TWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 489
W +D R L A + + SL+I +D G Y N+ G + +V + V +
Sbjct: 6677 KWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736
Query: 490 A---PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG--- 543
P + G V + C SG + W ++ + +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC 6796
Query: 544 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE 603
TL + + P D G Y+C A N G+D+ + L +PPS V V G
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSV 6856
Query: 604 ASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDAS 658
G PP +V W++G E++ + S +L + Q ++G Y+C N+ G AS
Sbjct: 6857 IRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSAS 6916
Query: 659 AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 718
L V + D +VE G +L TG PP +V+W + + L + R
Sbjct: 6917 CTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDE----YLISQSER 6972
Query: 719 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 778
S + S +L ED A Y C N G+ EA +V+ PP V
Sbjct: 6973 CSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEA--LVSVLEPPYFIEPLEHVE 7030
Query: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRALQEHAGR 835
+ G+P +L C V G P W K+ L + ++ SL +++ G
Sbjct: 7031 AVIGEPATLQCKV-DGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGE 7089
Query: 836 YSCVATNTAGSQHRDVELVV---QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITW 892
YSC A N+ G+ LV+ ++PP G P + C +G ++W
Sbjct: 7090 YSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSW 7149
Query: 893 TKETNALTSRGPHYN--VSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN--- 947
K+ L V TL I Q G Y C+A+N +G +S +L ++
Sbjct: 7150 YKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHE 7209
Query: 948 TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL 1007
P + P+ V GE T C G+ P +TW KD+R + P N L
Sbjct: 7210 VPPFFDLK-------PVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTL 7262
Query: 1008 PSGSLRLAQVQV--GDSGHYECTASNPAGSASHRYVLGVQ 1045
+ L ++V GD+G Y C ASN AG S LGVQ
Sbjct: 7263 VENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ 7302
Score = 191 bits (485), Expect = 4e-48
Identities = 173/739 (23%), Positives = 278/739 (37%), Gaps = 49/739 (6%)
Query: 329 VSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEILRASKAEEGTYECTAVSRA 385
+ C V +LP Q + + ++ + S E+ + Y C + A
Sbjct: 5256 MECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVA 5315
Query: 386 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 445
G + V +PP LV P T + G P+ + W +D L +
Sbjct: 5316 GDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPK 5375
Query: 446 RVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHF 502
L + L + + + G+Y C +N G + LLV E P+ V +S+
Sbjct: 5376 CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIV 5435
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNYS 559
G ++ C +G P + W R L + +D+ + + ++ ED+G++
Sbjct: 5436 KAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
C+A N G+ + + +PP S+ +V E L CE SG PP V+WY+
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKR 5555
Query: 620 EMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL 674
++ + + + K + I D G Y C+A NE+G + + + P+
Sbjct: 5556 QLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSK 5615
Query: 675 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ----PDSGVL 730
+TV G A L G P V W + + + R S + + + L
Sbjct: 5616 LNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVI-------RESENIRITFVENVATL 5668
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
F P + Y+C+ +N G + A L+V P I A + V G+ +L C
Sbjct: 5669 QFAKAEPANAGKYICQIKNDGGMRENMATLMVL--EPAVIVEKAGPMTVTVGETCTLECK 5726
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSI---RADGSLHLDRALQEHAGRYSCVATNTAGSQ 847
V AG P W KDG+ L +H SL + ++ AG Y+ N G
Sbjct: 5727 V-AGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKS 5785
Query: 848 HRDVELVVQVPPR-IHPTATHHITNE----GVPASLPCVASGVPAPTITWTKETNALTSR 902
VV V R + P+ T + N G L C +G ++ W E + S
Sbjct: 5786 --SCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSG 5843
Query: 903 GPHYNVSKEG--TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
+ + TL + + D G Y C A N G L+V P
Sbjct: 5844 AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSF-------V 5896
Query: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV--PPITNRYGLLPSGSLRLAQVQ 1018
P + G+ VT +G+PP V W + +R + N Y L L +
Sbjct: 5897 KEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNID 5956
Query: 1019 VGDSGHYECTASNPAGSAS 1037
+ SG Y C SN AG AS
Sbjct: 5957 ISQSGEYTCVVSNNAGQAS 5975
Score = 190 bits (482), Expect = 8e-48
Identities = 188/708 (26%), Positives = 281/708 (39%), Gaps = 77/708 (10%)
Query: 385 AGTGRAKAQIVVTDP-PPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 442
AG R+ + V P PPQ++ VTV G+ A + G ++W ++ ++L
Sbjct: 3222 AGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-- 3279
Query: 443 STGRVAQL----ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV----- 493
STG + + +L + P D Y C A N GV S L V E P+V
Sbjct: 3280 STGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV-EVPEVVSPDQ 3338
Query: 494 -------SIHTSSQH--FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DA 541
+I T Q S+G + C SG +SW + + ++ + +
Sbjct: 3339 EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED 3397
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-------------SAVNA 588
L I PED G Y+ A+N VG T L P S+ A
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457
Query: 589 V------VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIPA 637
+ + VA+G A CE P R W++ G E+ + + S L I
Sbjct: 3458 IKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILR 3517
Query: 638 AQERDAGTYTCRAVNELGDASAEIQLAVGHA--PQLTELPRDVTVELGRSALLACRATGR 695
Q D G YTC+A NE G S L V A P P+ +T +G++A C TG
Sbjct: 3518 TQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGT 3577
Query: 696 PPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ 755
P W++ DG L + S + +L ++ +D+ Y C+A N FG
Sbjct: 3578 PVIETIWQK-DGAALS---PSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADI 3633
Query: 756 AEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH 815
+A LI+ P V+ + V L C V R + W KDG+ LPPG +
Sbjct: 3634 CQAELIIID--KPHFIKELEPVQSAINKKVHLECQVDEDRKVTVT-WSKDGQKLPPGKDY 3690
Query: 816 SIRAD---GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR-IHPTATHHITN 871
I + +L + A + +G Y C A+N AGS + V+ PP + ++
Sbjct: 3691 KICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLML 3750
Query: 872 EGVPASLPCVASGVPAPTITWTKETNALTSRGP--HYNVSKEGTLLIAQPSAQDAGAYVC 929
G A L C G P +TW K L+ Y V+ E L I +D+G+Y C
Sbjct: 3751 PGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSC 3810
Query: 930 TATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVT 989
A N VG S + + P + A++ G L CE G+ P ++
Sbjct: 3811 EAVNDVGSDSCSTEIVIKEPPSF-IKTLEPADI------VRGTNALLQCEVSGTGPFEIS 3863
Query: 990 WTKDSRPVPPITNRYGLLPSGSLRLAQV---QVGDSGHYECTASNPAG 1034
W KD + + + +Y L SL ++ D G YEC +N G
Sbjct: 3864 WFKDKKQIRS-SKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Score = 187 bits (475), Expect = 5e-47
Identities = 182/727 (25%), Positives = 281/727 (38%), Gaps = 77/727 (10%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP------------PPQLV-PAPNVTVS 412
++ A + Y C A + G A + V P PP ++ P + S
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTS 3357
Query: 413 PGETAVLSCRVLGEAPYNLTWV-RDWRVLPASTGRVAQLAD-LSLEISGIIPTDGGRYQC 470
G+ A CRV G ++W +D ++ P+ R+ Q D LEI+ P D G Y
Sbjct: 3358 EGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTF 3416
Query: 471 VASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV---------------------- 508
VASNA G ++ L + EAP+ +H + Q +E+
Sbjct: 3417 VASNAVGQVSSTANLSL-EAPESILH---ERIEQEIEMEMKAAPVIKRKIEPLEVALGHL 3472
Query: 509 -KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATN 564
K +C P W + + + E + + + +L I D G Y+C+A+N
Sbjct: 3473 AKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASN 3532
Query: 565 EVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI 622
E G+ T TL T+ PP+ + + VG+ A +C +G P IW + G +
Sbjct: 3533 EYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALS 3592
Query: 623 LAP-----EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD 677
+P + + L + +D G Y+C+A N+ G + +L + P +
Sbjct: 3593 PSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEP 3652
Query: 678 VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS-GVLFFESVA 736
V + + L C+ TVTW + DGQ +L G+ + D L
Sbjct: 3653 VQSAINKKVHLECQVDEDRKVTVTWSK-DGQ----KLPPGKDYKICFEDKIATLEIPLAK 3707
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGR 795
+D YVC A N G A VT PP P+ +L G+ L C L G
Sbjct: 3708 LKDSGTYVCTASNEAGSSSCSA--TVTVREPPSFVKKVDPSYLMLPGESARLHC-KLKGS 3764
Query: 796 PLPERHWLKDGRPLPPGS---RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 852
P+ + W K+ + L + + + ++ L + E +G YSC A N GS E
Sbjct: 3765 PVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTE 3824
Query: 853 LVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 912
+V++ PP T G A L C SG I+W K+ + S + S++
Sbjct: 3825 IVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKS 3884
Query: 913 --TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
L I ++ D G Y C N VG + P + A
Sbjct: 3885 LVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVD-------DLIALG 3937
Query: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG--SLRLAQVQVGDSGHYECT 1028
G+ VTL +GS P VTW K + +G L + VQ+ G Y C
Sbjct: 3938 GQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 1029 ASNPAGS 1035
A N AGS
Sbjct: 3998 AENEAGS 4004
Score = 184 bits (466), Expect = 6e-46
Identities = 189/753 (25%), Positives = 285/753 (37%), Gaps = 51/753 (6%)
Query: 338 PFRLQLRRGEARL--GEERHFQ-ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
PF + +G + L G+ + E + E+ ++ G Y C + AG +
Sbjct: 7803 PFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHL 7862
Query: 395 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADL 453
+ P + + ++ G+ +L G P ++TW ++ V P+ +
Sbjct: 7863 YIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKS 7922
Query: 454 S-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 512
+ LEI D G+Y C NA+G S +L+ E P S G + C
Sbjct: 7923 AILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQC 7982
Query: 513 SASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTD 569
+G P +SW + L+ + + + TL+ V D+G Y C+A N VG
Sbjct: 7983 QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEV 8042
Query: 570 QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE 626
+ L + PPS S V VG V C SG P V WY+ G + +P
Sbjct: 8043 SASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPN 8102
Query: 627 GSSS-----GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--GHAPQLTEL---PR 676
+S L I AG Y+C A N +G AS+ +L + G P ++ P
Sbjct: 8103 VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPV 8162
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
D V G SA C TG P V+W + + +R G G+ S +S L V
Sbjct: 8163 DAVV--GESADFECHVTGTQPIKVSWAKDSRE---IRSG-GKYQISYLENSAHLTVLKVD 8216
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHA-PPQIASS-APTVRVLEGQPVSLPCIVLAG 794
D Y C A N GK A+L + PP + TV EG L V
Sbjct: 8217 KGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS 8276
Query: 795 RPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDV 851
+P+ W K+ + P S I + L + +A AG Y+C +N AGS
Sbjct: 8277 QPITVA-WYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS 8335
Query: 852 ELVVQVPPRIHPTATHHIT----NEGVPASLPCVASGVPAPTITWTKETNAL--TSRGPH 905
+V++ P + P H+T +EG L C G I W K + + R
Sbjct: 8336 SIVIKEPKK-PPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSF 8394
Query: 906 YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA----- 960
S L + + D+G YVC A+N G + + ++++ KP + + A
Sbjct: 8395 SFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRL 8454
Query: 961 ---NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRL 1014
+ P + T + G P P V WTK R + G L +
Sbjct: 8455 FFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEI 8514
Query: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQGR 1047
DSG Y C A N G L V R
Sbjct: 8515 RDTTKTDSGLYRCVAFNEHGEIESNVNLQVDER 8547
Score = 184 bits (466), Expect = 6e-46
Identities = 178/662 (26%), Positives = 271/662 (40%), Gaps = 58/662 (8%)
Query: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
EI ++ + G Y C + +G AQI++ +PP + V VS G++A L C++
Sbjct: 7926 EIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLA 7985
Query: 425 GEAPYNLTWVR-DWRVLPASTGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRAS 482
G ++W + D ++ P +T ++ +++ L + + D G Y C A N+ G AS
Sbjct: 7986 GTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAS 8045
Query: 483 VWLLVREA---PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH- 538
+L V+E P S + G+ V C+ SG +SW ++ + L++ +
Sbjct: 8046 TFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQT 8105
Query: 539 --VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVA 593
+D TL I AG YSC ATN +G+ + L T+ PP A V
Sbjct: 8106 SFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAV 8165
Query: 594 VGEEAVLVCEASGVPPPRVIWYR-------GGLEMILAPEGSSSGKLRIPAAQERDAGTY 646
VGE A C +G P +V W + GG I E S+ L + + D+G Y
Sbjct: 8166 VGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAH--LTVLKVDKGDSGQY 8223
Query: 647 TCRAVNELGDASAEIQLAVGHA---PQLTE-LPRDVTVELGRSALLACRATGRPPPTVTW 702
TC AVNE+G S QL + P T+ L V G S L R G P TV W
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAW 8283
Query: 703 RRG--DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
+ + QP + + ++ VL D Y C+ N G + +
Sbjct: 8284 YKNNIEIQP------TSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI 8337
Query: 761 IVTG-HAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR- 818
++ PP V V EG+ V L C V P+ WLK GR + P R S
Sbjct: 8338 VIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI-RIQWLKAGREIKPSDRCSFSF 8396
Query: 819 ADGS--LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN----- 871
A G+ L L + +G Y C A+N AGS ++ ++ P + P +
Sbjct: 8397 ASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFF 8456
Query: 872 ----------EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT---LLIAQ 918
E A+ G P P + WTK ++G + ++G L I
Sbjct: 8457 VSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRD 8516
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVN-TKPRIHMNGSRNANVPLQVTAK--AGEEVT 975
+ D+G Y C A N G + L V+ K + + G A + K AGEE
Sbjct: 8517 TTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEE 8576
Query: 976 LD 977
+D
Sbjct: 8577 ID 8578
Score = 167 bits (424), Expect = 4e-41
Identities = 171/631 (27%), Positives = 236/631 (37%), Gaps = 67/631 (10%)
Query: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLVR--EAPQVSIHTSSQHFSQGVEVKVSCSA 514
IS +D G Y VA G R+SV L V E PQV G +
Sbjct: 3207 ISETRQSDAGEYTFVA----GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVI 3262
Query: 515 SGYPTPHISWSRESQALQEDSR---IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 571
SG P P ISW +E Q L + +H + TL++ PEDA Y+C+A N+ G
Sbjct: 3263 SGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATT 3322
Query: 572 TVTLYYTDPPSVSAVNAV-------------VLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
+ +L P VS + + + G+ A C SG +V WY
Sbjct: 3323 SASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKD 3381
Query: 619 LEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASA-------------- 659
++ + + +L I A D GTYT A N +G S+
Sbjct: 3382 KKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILH 3441
Query: 660 -----EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
EI++ + AP + + V LG A C P W + +
Sbjct: 3442 ERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDK 3501
Query: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
+ R S+ L D Y C+A N +G V A L VT PP S
Sbjct: 3502 CSIRSSKYISS----LEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRP 3557
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH---LDRALQE 831
++ G+ C V G P+ E W KDG L P I + H L +
Sbjct: 3558 KSLTTFVGKAAKFICTV-TGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQ 3616
Query: 832 HAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTIT 891
G YSC A+N G+ EL++ P + L C T+T
Sbjct: 3617 DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVT 3676
Query: 892 WTKETNALTSRGPHYNV---SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT 948
W+K+ L G Y + K TL I +D+G YVCTA+N G SS ++V
Sbjct: 3677 WSKDGQKLPP-GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE 3735
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP--ITNRYGL 1006
P S V GE L C+ KGSP VTW K+++ + Y +
Sbjct: 3736 PP------SFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFV 3789
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
L + V+V DSG Y C A N GS S
Sbjct: 3790 NSEAILDITDVKVEDSGSYSCEAVNDVGSDS 3820
Score = 162 bits (411), Expect = 1e-39
Identities = 184/760 (24%), Positives = 276/760 (36%), Gaps = 67/760 (8%)
Query: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHF---QESGNSSWEILRASKAEEGTYECTA 381
QP C V S ++ + ++ R F Q EI A +EGTY A
Sbjct: 3360 QPARFQCRV-SGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA 3418
Query: 382 VSRAGTGRAKAQIVVTDPPP------------QLVPAPNV-------TVSPGETAVLSCR 422
+ G + A + + P ++ AP + V+ G A +C
Sbjct: 3419 SNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478
Query: 423 VLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTR 480
+ W + R + S + + SLEI D G Y C ASN G
Sbjct: 3479 IQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVS 3538
Query: 481 ASVWLLVREA--PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 538
+ L V EA P S G K C+ +G P W ++ AL
Sbjct: 3539 CTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWR 3598
Query: 539 V-DAQGTLIIQ--GVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVG 595
+ DA+ I++ + +D G YSC+A+N+ G D L D P V A+
Sbjct: 3599 ISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAIN 3658
Query: 596 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEG--------SSSGKLRIPAAQERDAGTYT 647
++ L C+ V W + G ++ P G L IP A+ +D+GTY
Sbjct: 3659 KKVHLECQVDEDRKVTVTWSKDGQKL---PPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 648 CRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL-GRSALLACRATGRPPPTVTWRRGD 706
C A NE G +S + V P + + L G SA L C+ G P VTW + +
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNN 3775
Query: 707 GQPLGLRLGAGRGSRSRQPDS-GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 765
+ L R +S +L V ED Y CEA N G +++
Sbjct: 3776 KE-----LSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI--K 3828
Query: 766 APPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS--- 822
PP + ++ G L C V P E W KD + + ++ + + S
Sbjct: 3829 EPPSFIKTLEPADIVRGTNALLQCEVSGTGPF-EISWFKDKKQIRSSKKYRLFSQKSLVC 3887
Query: 823 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 882
L + G Y CV N G +++ PP I G +L
Sbjct: 3888 LEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAV 3947
Query: 883 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDA--GAYVCTATNTVGFSSQ 940
G ++TW K + G G ++ P Q + G Y C A N G +
Sbjct: 3948 RGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTS 4007
Query: 941 EMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1000
L V +I +QVT AG+ TL+ G+P W KD RP+
Sbjct: 4008 VGELIVKEPAKIIERAEL-----IQVT--AGDPATLEYTVAGTPELKPKWYKDGRPL-VA 4059
Query: 1001 TNRYGLLPSGS---LRLAQVQVGDSGHYECTASNPAGSAS 1037
+ +Y + + L+ ++ DSG Y SN GS+S
Sbjct: 4060 SKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSS 4099
Score = 114 bits (284), Expect = 7e-25
Identities = 175/829 (21%), Positives = 290/829 (34%), Gaps = 113/829 (13%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHFQES---GNSSWEILRASKAEEGTYECTAVSRAGT 387
C V P ++ + + +Q S ++ +L+ K + G Y C AV+ G
Sbjct: 8174 CHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233
Query: 388 GRAKAQIVVTDP--PPQLVPAPNVTV--SPGETAVLSCRVLGEAPYNLTWVRD-WRVLPA 442
AQ+ + + PP + TV + G + L RV G P + W ++ + P
Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293
Query: 443 STGRVA-QLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA---PQVSIHTS 498
S + + L L++ D G Y C SN G + ++++E P H +
Sbjct: 8294 SNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLT 8353
Query: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD-AQGTLIIQ--GVAPEDA 555
S+G V++SC G I W + + ++ R A GT +++ VA D+
Sbjct: 8354 PVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADS 8413
Query: 556 GNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAV---------------VLVAVGEEAVL 600
G+Y C+A+N G+D + D P+V+ + V A
Sbjct: 8414 GDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATF 8473
Query: 601 VCEASGVPPPRVIWYRG-------GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 653
+ + G P P V W +G G + + +G + KL I + D+G Y C A NE
Sbjct: 8474 IAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEA-KLEIRDTTKTDSGLYRCVAFNE 8532
Query: 654 LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR--------------PPPT 699
G+ + + L V + ++ D+ L ++ +L + G P
Sbjct: 8533 HGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILK-KGAGEEEEIDIMELLKNVDPKEY 8591
Query: 700 VTWRR--GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAE 757
+ R G GL +S++ ++ L E + ++ E F +
Sbjct: 8592 EKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSF----IQ 8647
Query: 758 ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSI 817
RL T P + VL+ + P + W K L P + I
Sbjct: 8648 QRLSQT--EPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEI 8705
Query: 818 RADGSLHLDRALQ---EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN--- 871
DG H R + G Y V G +L V I P H+ +
Sbjct: 8706 SIDGDRHTLRVKNCQLKDQGNYRLV----CGPHIASAKLTV-----IEPAWERHLQDVTL 8756
Query: 872 -EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN--VSKEGTLLIAQPSAQDAGAYV 928
EG ++ C S VP W + L +G H K L IA A+D G Y
Sbjct: 8757 KEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYT 8815
Query: 929 CTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988
C + L + + RI + + + T +CE +V
Sbjct: 8816 CKYED----------LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEV-SFDDAIV 8864
Query: 989 TWTKDSRPVPPITNRYGLLPSGS---LRLAQVQVGDSGHYECTA----SNPAGSASHRYV 1041
TW K + + +Y G + + V D G Y A A S + Y+
Sbjct: 8865 TWYKGPTELTE-SQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYL 8923
Query: 1042 LGVQGRTSWQPQSLP--------------VPHHPACLSGLSVPLLQPTP 1076
+ + +P +P P + +PLL PTP
Sbjct: 8924 TTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTP 8972
Score = 99.8 bits (247), Expect = 1e-20
Identities = 167/705 (23%), Positives = 263/705 (37%), Gaps = 125/705 (17%)
Query: 333 VHSALPFRLQLRRGEARLGEERHFQESGN-------------SSWEILRASKAEEGTYEC 379
+ S++ F++ + G ARL F E S+ L +EE E
Sbjct: 983 IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKET 1042
Query: 380 TAVSRAGTGRAKA-----QIVVTDPP-------PQLVPAPNVTVSP-------GETAVLS 420
TAV+ T K +V+TD P AP P G + V
Sbjct: 1043 TAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFG 1102
Query: 421 CRVLGEAPYNLTWVRDWRVLPASTG---RVA---QLADLSLEISGIIPTDGGRYQCVASN 474
C+V G ++ W + +P +TG +V+ Q + L IS D G Y V N
Sbjct: 1103 CQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRN 1160
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV-------KVSCSASG--YPTPHISWS 525
+G T AS LL EA + S Q +V KV +A G Y +
Sbjct: 1161 KHGETSASASLL-EEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYE 1219
Query: 526 RESQALQ--------------EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 571
+E ++ ED H+ + +I+ + + E G ++
Sbjct: 1220 KEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKM 1279
Query: 572 TVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--------LEM 621
V + ++ + + + G C+ SG P P++ WY+ G +M
Sbjct: 1280 AVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQM 1339
Query: 622 ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVE 681
+G +S LRIP D G YT A N G+A +L V A L T+E
Sbjct: 1340 DFLQDGRAS--LRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1397
Query: 682 -LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 740
+ R L+ R+ R P +R+ R S +R + ++P
Sbjct: 1398 PVSRIRSLSPRSVSRSP--------------IRMSPARMSPARMSPA------RMSPARM 1437
Query: 741 APYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER 800
+P R + +++ + P + + LEGQ V+ GRP+PE
Sbjct: 1438 SP----GRRLEETDESQLERLYK----PVFVLKPVSFKCLEGQTARFDLKVV-GRPMPET 1488
Query: 801 HWLKDGRPLPPGSRHS--IRADG--SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856
W DG+ + H I+ DG SL + A +G ++ VA N AG V L V+
Sbjct: 1489 FWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVE 1548
Query: 857 -VPPRIHPTATHHITN----EGVPASLPCVASGVPAPTITWTKETNALTSRGPHY--NVS 909
V ++ P + N EG + A+G P P I W K ++ + PH +
Sbjct: 1549 AVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIV---PHKYPKIR 1605
Query: 910 KEGT-----LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
EGT L I +QD+ Y TA N G + +++V +
Sbjct: 1606 IEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVE 1650
Score = 97.1 bits (240), Expect = 9e-20
Identities = 147/638 (23%), Positives = 218/638 (34%), Gaps = 130/638 (20%)
Query: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH-VDAQG--TLI 546
AP++++ S G + + PT + W LQE S+IH + G TL
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLE 32432
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP-------------------PSVSAVN 587
I +D+G Y TN G + TL T P ++
Sbjct: 32433 ILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTE 32492
Query: 588 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT 647
A + + + + + EAS E + + E S+S +++ A +E+
Sbjct: 32493 AYAVSSFKKTSEM--EASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKS----- 32545
Query: 648 CRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 707
L + S ++ A ++ PR +TV G SA +C G P PTVTW R G
Sbjct: 32546 ------LEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLR-KG 32598
Query: 708 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV----- 762
Q L + R + SV D+ Y N GK +AE L +
Sbjct: 32599 QVLST---SARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARV 32655
Query: 763 ---TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL-PERHWLKDGRPLPPGSRHSIR 818
+PP++ S P RV + V P V + P P+ + +P P
Sbjct: 32656 TEKAVTSPPRVKSPEP--RVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTP-------- 32705
Query: 819 ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL 878
T QH L V PP+I + E A L
Sbjct: 32706 ------------------------TEKVQH----LPVSAPPKITQFLKAEASKE--IAKL 32735
Query: 879 PCV--ASGVPAPTITWTKETNALTSRGP---HYNVSKEGTLLIAQPSAQDAGAYVCTATN 933
CV +S + A +TW K+ L G HY+ L I + D G YVC +
Sbjct: 32736 TCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISG 32795
Query: 934 TVGFSSQEMRLSVNTKPRIHMNGSRNANV---------------------------PLQV 966
G S ++ IH S+ + P+ V
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIV 32855
Query: 967 TAKAGEEVTLDCEAK------GSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRLAQV 1017
T V+ D AK G P P WTKD + + +Y L L + +
Sbjct: 32856 TGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQ-GGKYKLSEDKGGFFLEIHKT 32914
Query: 1018 QVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSL 1055
DSG Y CT N AGS S L ++ + Q +
Sbjct: 32915 DTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKV 32952
Score = 92.0 bits (227), Expect = 3e-18
Identities = 161/744 (21%), Positives = 258/744 (34%), Gaps = 121/744 (16%)
Query: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 421
SS+E +++ + E ++ T R +I T L ++TV GE+A SC
Sbjct: 32526 SSYEHSASAEMKSAALEEKSLEEKSTTR---KIKTTLAARILTKPRSMTVYEGESARFSC 32582
Query: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVT 479
GE +TW+R +VL S + EIS + +D G Y V N+ G
Sbjct: 32583 DTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQ 32642
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
A L +++A + + + VK P P + + +A++ R+
Sbjct: 32643 EAEFTLTIQKA-----RVTEKAVTSPPRVK-------SPEPRV---KSPEAVKSPKRVK- 32686
Query: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT-LYYTDPPSVSAVNAVVLVAVGEEA 598
+PE + + T T E V L + PP ++ + A E A
Sbjct: 32687 -----------SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKIT--QFLKAEASKEIA 32733
Query: 599 VLVC--EASGVPPPRVIWYRGGLEMILAPEG------SSSG--KLRIPAAQERDAGTYTC 648
L C E+S + V WY+ G + L G S+ G +L+I E D G Y C
Sbjct: 32734 KLTCVVESSVLRAKEVTWYKDGKK--LKENGHFQFHYSADGTYELKINNLTESDQGEYVC 32791
Query: 649 RAVNELGDASAEIQL----------------------------------------AVGHA 668
E G + +Q +
Sbjct: 32792 EISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSK 32851
Query: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
P + +D TV A A +ATG P PT W + DG+ + G D G
Sbjct: 32852 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK-DGKAI-----TQGGKYKLSEDKG 32905
Query: 729 VLFFE--SVAPEDQAPYVCEARNVFGKVQAEARLIVTG--------HAPPQIASSAPTVR 778
F E D Y C +N G V + +L + + + + P +
Sbjct: 32906 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKK 32965
Query: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 838
+ + +S + + E + S+ I + +L++
Sbjct: 32966 AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 33025
Query: 839 VATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNA 898
T+ A + V+ I +T NEG L +G A + W
Sbjct: 33026 TKTSQASEE-------VRTHAEIKAFSTQMSINEGQRLVLKANIAG--ATDVKWVLNGVE 33076
Query: 899 LT-SRGPHYNVS-KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNG 956
LT S Y VS + TL I Q S +D G C + G + L+++ + +
Sbjct: 33077 LTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE---LSDA 33133
Query: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG---SLR 1013
+ P G+ V CE G P P + W K++ P+ I++ + S SL
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPI-SISSNVSISRSRNVYSLE 33192
Query: 1014 LAQVQVGDSGHYECTASNPAGSAS 1037
+ V DSG Y A N G S
Sbjct: 33193 IRNASVSDSGKYTIKAKNFRGQCS 33216
Score = 91.7 bits (226), Expect = 4e-18
Identities = 94/326 (28%), Positives = 136/326 (41%), Gaps = 58/326 (17%)
Query: 583 VSAVNAVVLVAVGEEA---VLVCEASGVPPP-RVIWYRGGLEM-------ILAPEGSSSG 631
+ V+ ++ AVGEE VC+ +V WY G ++ I +G +
Sbjct: 31567 IGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAI- 31625
Query: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---------------------GHAPQ 670
L + + D GTY C+ VN+ G+ S+ +L V +
Sbjct: 31626 -LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR 31684
Query: 671 LTELPRDVTVEL-------GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR 723
L E P + T+ L G + T P P VTW + GQ ++ G +
Sbjct: 31685 LLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYK-SGQK--IKPGDNDKKYTF 31741
Query: 724 QPDSGV--LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL- 780
+ D G+ L SV +D A Y ARN +G+ +A+L VT H PP ++ P + L
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 781 ------EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG----SLHLDRALQ 830
EGQ V I ++G P P W KDG+PL G I +G +LH+ L
Sbjct: 31802 ANAECQEGQSVCFE-IRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 31860
Query: 831 EHAGRYSCVATNTAGSQHRDVELVVQ 856
E G Y ATNTAGS L V+
Sbjct: 31861 EDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 90.5 bits (223), Expect = 9e-18
Identities = 142/622 (22%), Positives = 218/622 (35%), Gaps = 61/622 (9%)
Query: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA 514
L + I P+D G Y V + V E ++ + + C
Sbjct: 2851 LMLQNISPSDAGEYTAVVGQLECKAKLFV-----ETLHITKTMKNIEVPETKTASFECEV 2905
Query: 515 SGYPTPHISWSRESQALQEDSRIHVDAQGTL---IIQGVAPEDAGNYSCQATNEVGTDQE 571
S + P + W + ++ + + QG L II + ED+ Y T G DQ
Sbjct: 2906 SHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEY----TFVCGNDQV 2960
Query: 572 TVTLYYTDPPSVSA---VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS 628
+ TL T S +NA + E + E W + G+E+ +
Sbjct: 2961 SATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISYK-----WLKNGVEIKSTDKCQ 3015
Query: 629 SSGK-----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
K L I DA YT A A+ ++ + + +D+ V
Sbjct: 3016 MRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE---ARHIEFRKHIKDIKVLEK 3072
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
+ A+ C + P TV W + D Q L + R ++ L S D Y
Sbjct: 3073 KRAMFECEVS-EPDITVQWMKDD-QELQI---TDRIKIQKEKYVHRLLIPSTRMSDAGKY 3127
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
A G + A+L V G +I S V+V+E Q + V + HW
Sbjct: 3128 TVVA----GGNVSTAKLFVEGR-DVRIRSIKKEVQVIEKQRAVVEFEV--NEDDVDAHWY 3180
Query: 804 KDGRPL--PPGSRHSIRADGSLH---LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
KDG + RH + +H + Q AG Y+ VA G V L V P
Sbjct: 3181 KDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP 3236
Query: 859 --PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS--RGPHYNVSKEGTL 914
P++ G PA V SG P P I+W KE L++ + + +E TL
Sbjct: 3237 EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVT------A 968
L+ + +DA Y C A N G ++ LSV + + P +T
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3356
Query: 969 KAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG-SLRLAQVQVGDSGHYEC 1027
G+ C G+ + ++KD + P R L +A+ D G Y
Sbjct: 3357 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTF 3416
Query: 1028 TASNPAGSASHRYVLGVQGRTS 1049
ASN G S L ++ S
Sbjct: 3417 VASNAVGQVSSTANLSLEAPES 3438
Score = 88.2 bits (217), Expect = 4e-17
Identities = 158/694 (22%), Positives = 259/694 (37%), Gaps = 119/694 (17%)
Query: 346 GEARLGEERHFQESGNSSWEILRASKAEE------GTYECT-------AVSRAGTGRA-- 390
G+ LG +++SG+S+W+ + ++ G E T A + G R
Sbjct: 30459 GKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 30518
Query: 391 -----KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL----- 440
K ++ + P +VT GE A LSC+++G ++ W R + L
Sbjct: 30519 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRK 30578
Query: 441 --PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH-- 496
+S GR L ++ E D G Y C+A+N G S LL++ PQ H
Sbjct: 30579 YKMSSDGRTHTLTVMTEE-----QEDEGVYTCIATNEVGEVETSSKLLLQATPQ--FHPG 30631
Query: 497 ---TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI---HVDAQGTLIIQGV 550
+ + G +++ G P P ++W + LQ I + + L+++ V
Sbjct: 30632 YPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNV 30691
Query: 551 APE-DAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP 609
+ AG Y Q +N GT + + D P V+ + AV+ S PP
Sbjct: 30692 QRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVI----SWKPP 30747
Query: 610 PRVIWYRGG-------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ 662
GG +E A EG+ + TCR VN +A +
Sbjct: 30748 AD----DGGSWITNYVVEKCEAKEGAEWQLV------SSAISVTTCRIVNLTENAGYYFR 30797
Query: 663 LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG--- 719
++ + +++ +V + +S A G+ PT+T D + + A G
Sbjct: 30798 VSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGK--PTITAVTKDSCVVAWKPPASDGGAK 30855
Query: 720 -------SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR------------- 759
R ++ + + SV E+ V +N+ ++ E R
Sbjct: 30856 IRNYYLEKREKKQNKWI----SVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWS 30911
Query: 760 -----LIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV--LAGRPLPERHWLKDGRP-LPP 811
+ P Q +R L + S +V + G P P W + G+ +
Sbjct: 30912 EISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD 30971
Query: 812 GSRHSIRA-DGSLH---LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH----- 862
G ++ I+ G H + + A Y ATN GS L V+VP +IH
Sbjct: 30972 GLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTL 31031
Query: 863 --PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN--VSKEGTLLIAQ 918
A H + E V +P SG P P ITW K + + + G HY V++ T L+
Sbjct: 31032 EGMGAVHALRGEVVSIKIP--FSGKPDPVITWQKGQDLIDNNG-HYQVIVTRSFTSLVFP 31088
Query: 919 PSAQ--DAGAYVCTATNTVGFSSQEMRLSVNTKP 950
+ DAG YV A N G + + L V P
Sbjct: 31089 NGVERKDAGFYVVCAKNRFGIDQKTVELDVADVP 31122
Score = 86.7 bits (213), Expect = 1e-16
Identities = 168/795 (21%), Positives = 274/795 (34%), Gaps = 151/795 (18%)
Query: 387 TGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPAST 444
T R A + + PP LV NVTV GE+ L C + G +TW R D+++ +
Sbjct: 929 TARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 445 GRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS---- 499
++ + ++ L I D GR+ C A N G S +L V+ + + T++
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEK 1048
Query: 500 ------------------------------------------QHFSQGVEVKVSCSASGY 517
Q +G V C G
Sbjct: 1049 FTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGN 1108
Query: 518 PTPHISWSRESQALQEDSRIHVD-----AQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 572
P PH+ W + L R V + L+I +DAG Y+ N+ G +
Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSAS 1168
Query: 573 VT-----------------LYYTDPPSVSAVNAVVLVAVG-----------EEAVLVCEA 604
+ LY T + V A G +E L+ +
Sbjct: 1169 ASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKK 1228
Query: 605 SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 664
V Y E + SS + I + R T + E G+ + ++
Sbjct: 1229 MAKDTVVVRTYVEDQEFHI----SSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDIS 1284
Query: 665 VGHAPQ--LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS 722
A + ++ + G C+ +G P P + W + DG+ + + G
Sbjct: 1285 ESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYK-DGKRI--KHGERYQMDF 1341
Query: 723 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT------ 776
Q L V PED+ Y A N+ G +L V AP + PT
Sbjct: 1342 LQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSR 1401
Query: 777 VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 836
+R L + VS I R P R + R P + + G R L+E
Sbjct: 1402 IRSLSPRSVSRSPI----RMSPAR--MSPARMSPARMSPARMSPG-----RRLEE----- 1445
Query: 837 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
+ +E + + + P + + EG A G P P W +
Sbjct: 1446 ---------TDESQLERLYKPVFVLKPVSFKCL--EGQTARFDLKVVGRPMPETFWFHDG 1494
Query: 897 NALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT----- 948
+ + H V KE +L+I + D+G + A N G SS + L+V
Sbjct: 1495 QQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQV 1554
Query: 949 KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY---- 1004
KP + + +N N+ K G + + A G+P P + W K+S + P ++Y
Sbjct: 1555 KP-MFVEKLKNVNI------KEGSRLEMKVRATGNPNPDIVWLKNSDIIVP--HKYPKIR 1605
Query: 1005 --GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQ---SLPVPH 1059
G +L++ DS Y TA N AG + R + V+ + +P+ L +P
Sbjct: 1606 IEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFA-EPEPERKLIIPR 1664
Query: 1060 HPACLSGLSVPLLQP 1074
++ P L+P
Sbjct: 1665 GTYRAKEIAAPELEP 1679
Score = 82.4 bits (202), Expect = 2e-15
Identities = 94/417 (22%), Positives = 158/417 (37%), Gaps = 32/417 (7%)
Query: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
+I K+++ T E T + KA ++ P + + TVS A + +
Sbjct: 32820 KISETKKSDQKTTESTVTRKT---EPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKAT 32876
Query: 425 GEAPYNLTWVRDWRVLPASTGRVAQLAD----LSLEISGIIPTDGGRYQCVASNANGVTR 480
GE W +D + + + G +L++ LEI +D G Y C N+ G
Sbjct: 32877 GEPRPTAIWTKDGKAI--TQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVS 32934
Query: 481 ASVWLLVR-----EAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQED 534
+S L ++ EA +VS +S+ Q V+ S + I S QE
Sbjct: 32935 SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKS--QEK 32992
Query: 535 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 594
+ +A LI + V A + +E T + + A + + +
Sbjct: 32993 LALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 33052
Query: 595 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCR 649
G+ VL +G V W G+E+ + E S L I A RD G TC
Sbjct: 33053 GQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCI 33110
Query: 650 AVNELGDASAEIQLA----VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRG 705
+ + G + L + AP PR + G++ L C +G P P + W +
Sbjct: 33111 SKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFK- 33169
Query: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
+ P+ + + S SR + L + + D Y +A+N G+ A A L+V
Sbjct: 33170 NNLPISI---SSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV 33223
Score = 82.0 bits (201), Expect = 3e-15
Identities = 57/212 (26%), Positives = 89/212 (41%), Gaps = 10/212 (4%)
Query: 395 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--- 451
+ T P P +V V G TA + G ++W RD +V+ ST Q++
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 452 -DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA---PQVSIHTSSQHFSQGVE 507
L I + + GRY A+N +G ++ LLV+ P S QG +
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 508 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATN 564
V++ +G PTP + + R+ +Q + +G +L+I PED+G YS ATN
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 565 EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 596
VG T L V A +V+ +
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ 212
Score = 76.3 bits (186), Expect = 2e-13
Identities = 84/369 (22%), Positives = 148/369 (40%), Gaps = 30/369 (8%)
Query: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNS-SWEILRASKAEEGTYECTAVS 383
Q L++ ++ A + L E EE + SG+ + I +AS +EG C + +
Sbjct: 33054 QRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKT 33113
Query: 384 RAGTGRAKAQIVVT----DPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 439
+ G + + + ++ D P + + ++ G+ + +C + GE + W ++
Sbjct: 33114 KEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKN--N 33171
Query: 440 LPASTGRVAQLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR---EAP- 491
LP S ++ SLEI +D G+Y A N G A+ L+V E P
Sbjct: 33172 LPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPS 33231
Query: 492 -QVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQEDSRI-HVDAQGTLII 547
+V + TS QG V SAS S+S S + + + + AQ +
Sbjct: 33232 REVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSM 33291
Query: 548 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTD----PPSVSAVNAVVLVAVGEEAVLVCE 603
Q E + + +N + T + PP + A+ + + + G+ + C
Sbjct: 33292 QESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACA 33351
Query: 604 ASGVPPPRVIWYRGGLEMILAPEG-------SSSGKLRIPAAQERDAGTYTCRAVNELGD 656
+G P P V W GG ++ +G L I Q++D G YT NE G
Sbjct: 33352 FTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Query: 657 ASAEIQLAV 665
SA + + +
Sbjct: 33412 DSATVNIHI 33420
Score = 71.2 bits (173), Expect = 5e-12
Identities = 65/266 (24%), Positives = 113/266 (42%), Gaps = 36/266 (13%)
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR---ADG--S 822
P +V VLEG + + +G P+PE W +DG+ + + ++ +DG
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHI-SGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 823 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PPRIHPTATHHITNEGVPASLP 879
L + + ++GRYS ATN +G EL+V+ PP +G L
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVG 936
+G+P P + + ++ + S + +S+EG +LLIA+ +D+G Y ATN+VG
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 937 FSSQEMRLSVNTKPRI------------HMNGSRNANVPLQVTAK------AGEEVTLDC 978
++ L V + + ++ SR + ++ A A E+ +D
Sbjct: 184 RATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDG 243
Query: 979 EA-----KGSPPPLVTWTKDSRPVPP 999
A +PP + K P PP
Sbjct: 244 AAGQQLPHKTPPRIPPKPKSRSPTPP 269
Score = 70.5 bits (171), Expect = 9e-12
Identities = 57/197 (28%), Positives = 80/197 (40%), Gaps = 14/197 (7%)
Query: 578 TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG-------LEMILAPEGSSS 630
T P+ + V+V G A SG P P V W+R G L +
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTELPRDVTVELGRSAL 687
KL IPA + ++G Y+ +A N G A++ +L V P + + +TV G
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122
Query: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 747
L R TG P P V + R DG + L S++ D L PED Y A
Sbjct: 123 LQVRVTGIPTPVVKFYR-DGAEIQSSLDF---QISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 748 RNVFGKVQAEARLIVTG 764
N G+ + A L+V G
Sbjct: 179 TNSVGRATSTAELLVQG 195
Score = 70.1 bits (170), Expect = 1e-11
Identities = 88/443 (19%), Positives = 167/443 (37%), Gaps = 29/443 (6%)
Query: 342 QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP 401
+++ EA+ E+ +E + K+ + E + V T ++A V
Sbjct: 32981 EIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAE 33040
Query: 402 QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--DLSLEISG 459
+ ++++ G+ VL + G ++ WV + L S ++ D +L I
Sbjct: 33041 IKAFSTQMSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQ 33098
Query: 460 IIPTDGGRYQCVASNANGVTRASVWLLVR----EAPQVSIHTSSQHFSQGVEVKVSCSAS 515
D G C++ G+ + L + +AP SQ+ ++G V +C S
Sbjct: 33099 ASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEIS 33158
Query: 516 GYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQET 572
G P+P I W + + + S + + +L I+ + D+G Y+ +A N G T
Sbjct: 33159 GEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSAT 33218
Query: 573 VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK 632
+L P VVL G+ ++ +S + SS +
Sbjct: 33219 ASLMVL-PLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTE 33277
Query: 633 LRIPAAQERDAGTYT-------------CRAVNELGDASAEIQLA--VGHAPQLTELPRD 677
++ + + + + +L +++++ A G P++ LP D
Sbjct: 33278 MKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSD 33337
Query: 678 VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
++++ G+ +AC TG P P VTW G G+ + + GR D L V
Sbjct: 33338 ISIDEGKVLTVACAFTGEPTPEVTWSCG-GRKIHSQ-EQGRFHIENTDDLTTLIIMDVQK 33395
Query: 738 EDQAPYVCEARNVFGKVQAEARL 760
+D Y N FG A +
Sbjct: 33396 QDGGLYTLSLGNEFGSDSATVNI 33418
Score = 69.7 bits (169), Expect = 2e-11
Identities = 88/360 (24%), Positives = 128/360 (35%), Gaps = 56/360 (15%)
Query: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 511
DL++ +S + GG + + GV+ A V + E VS +G VK
Sbjct: 31533 DLNMVVSAARISCGGAIR----SQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYV 31588
Query: 512 CSASGYP-TPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVG 567
C Y + ++W + L+ + + D L ++ + D G Y C+ N+ G
Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYG 31648
Query: 568 TDQETVTL----------YY-----------TD-------PPSVSAVNAVVLVAVGEEAV 599
D L YY TD PP + VGE
Sbjct: 31649 EDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVR 31708
Query: 600 LVCEASGVPPPRVIWYRGGLEMILAPEG------SSSG--KLRIPAAQERDAGTYTCRAV 651
+ P P V WY+ G ++ S G +L I + D YT A
Sbjct: 31709 FGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVAR 31768
Query: 652 NELGDASAEIQLAVGHAPQLTE---------LPRDVTVELGRSALLACRATGRPPPTVTW 702
N+ G+ S + +L V P T+ L + + G+S R +G PPPT+ W
Sbjct: 31769 NKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKW 31828
Query: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
+ DGQPL LG D L PED Y A N G +A L V
Sbjct: 31829 EK-DGQPLS--LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 67.4 bits (163), Expect = 8e-11
Identities = 131/568 (23%), Positives = 206/568 (36%), Gaps = 58/568 (10%)
Query: 389 RAKAQIVVTDPPPQLV-PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS---- 443
+ A + V +PP + P + TV G TAVL C V E + W ++ + S
Sbjct: 12273 KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA-KVKWFKNGTEILKSKKYE 12331
Query: 444 ---TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ 500
GRV +L I P D Y C A + +V V + +
Sbjct: 12332 IVADGRVRKLV-----IHDCTPEDIKTYTCDAKDFKTSCNLNV---VPPHVEFLRPLTDL 12383
Query: 501 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGN 557
+ + C S + W ++ +++ + + ++G L+I +D
Sbjct: 12384 QVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 12442
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSAVN-AVVLVAVGEEAVLVCEASGVPPPRVIWYR 616
YSC EV T + + L + +V N A + V+ + LVCE S P VIWY+
Sbjct: 12443 YSC----EVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVS-KPGAEVIWYK 12497
Query: 617 GGLEMILAP--EGSSSGKLRIPAAQE---RDAGTYTCRAVNELGDASAEIQLAVGHAPQL 671
G E+I E + G+ RI Q DAG Y CR + D ++ A +
Sbjct: 12498 GDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHEL---AAEF 12554
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVL 730
P+++ + G A C + P V W+R D G + + R VL
Sbjct: 12555 ISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKKR-----VL 12608
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
+ +D YV + G +A A L V +I RV E Q V C
Sbjct: 12609 VVKDATLQDMGTYVV----MVGAARAAAHLTVIEKL--RIVVPLKDTRVKEQQEVVFNCE 12662
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEH---AGRYSCVATNTAGSQ 847
V + W ++ + S++ I ++ R H Y+ TN G
Sbjct: 12663 V--NTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGEN 12720
Query: 848 HRDVE--LVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT-SRGP 904
+ +V + RI T E + C + + T+ WTK +
Sbjct: 12721 VKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNV-TLKWTKNGEEVPFDNRV 12779
Query: 905 HYNVSK-EGTLLIAQPSAQDAGAYVCTA 931
Y V K + L I D G Y+ TA
Sbjct: 12780 SYRVDKYKHMLTIKDCGFPDEGEYIVTA 12807
Score = 65.9 bits (159), Expect = 2e-10
Identities = 129/639 (20%), Positives = 232/639 (36%), Gaps = 73/639 (11%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVL 424
I A + G Y C R + R ++ V + + + P N+ + GE A C +
Sbjct: 12521 IQNAHLEDAGNYNC----RLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSIS 12576
Query: 425 GEAPYNLTWVRD---------WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475
E+ + + W RD + V+ RV + D +L+ D G Y +
Sbjct: 12577 KES-FPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQ-------DMGTYVVMV--- 12625
Query: 476 NGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS 535
G RA+ L V E ++ + + EV +C + W R +A+ + S
Sbjct: 12626 -GAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGAK-AKWFRNEEAIFDSS 12683
Query: 536 R---IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV 592
+ + D TL I+ +D NY+ TN G + ++ + + V + +
Sbjct: 12684 KYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDI 12743
Query: 593 AVGEEAVLV--CEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIPAAQERDAGT 645
E+ + C+ + + + W + G E+ S L I D G
Sbjct: 12744 ETMEKKSVTFWCKVNRLNVT-LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGE 12802
Query: 646 YTCRAVNELGDASAEIQLAVGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
Y A G + +L + AP + E D TV A+ +C+ + R V W R
Sbjct: 12803 YIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLS-REKANVKWYR 12857
Query: 705 GDGQPLGLRLGAGRGSRSRQPDS-GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
G + G+ + + S L + +D+ Y C + ++ ARL V
Sbjct: 12858 N-----GREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR----KSRARLFVE 12908
Query: 764 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 823
P +I P +LE + + + E WL++ + G +H + ++G +
Sbjct: 12909 -EIPVEIIR--PPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKI 12965
Query: 824 HLDRALQ---EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC 880
H + G Y +A + + +L + P+I + + G P ++
Sbjct: 12966 HRLQICDIKPRDQGEYRFIAKD----KEARAKLELAAAPKIKTADQDLVVDVGKPLTMVV 13021
Query: 881 VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 940
P W KE L+++ +++ + I + D G Y N G +
Sbjct: 13022 PYDAYPKAEAEWFKENEPLSTKTID-TTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEG 13080
Query: 941 EMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
+ L V P N L+VT EV+L E
Sbjct: 13081 FINLKVIDVPGPVRN--------LEVTETFDGEVSLAWE 13111
Score = 65.5 bits (158), Expect = 3e-10
Identities = 141/663 (21%), Positives = 219/663 (33%), Gaps = 150/663 (22%)
Query: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLAD--LSLEISGIIPTD 464
N + G C++ G + W +D R+ ++ L D SL I ++P D
Sbjct: 1299 NYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPED 1358
Query: 465 GGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP-HIS 523
G Y ASN G S L V A + T ++ S +P +S
Sbjct: 1359 EGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMS 1418
Query: 524 WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 583
+R S A +R+ A G + T+E ++ ++ P S
Sbjct: 1419 PARMSPARMSPARM-----------SPARMSPGR-RLEETDESQLERLYKPVFVLKPVSF 1466
Query: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI--------LAPEGSSSGKLRI 635
+ G+ A + G P P W+ G +++ + +G+ S L I
Sbjct: 1467 KCLE-------GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQS--LII 1517
Query: 636 PAAQERDAGTYTCRAVNELGDASAEIQL---AVGHA--PQLTELPRDVTVELGRSALLAC 690
A D+G +T A N G +S + L AV H P E ++V ++ G +
Sbjct: 1518 VPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKV 1577
Query: 691 RATGRPPPTVTWRRGDGQPLG-----LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
RATG P P + W + + +R+ +G + + DS V +D A Y
Sbjct: 1578 RATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV-------SQDSAWYTA 1630
Query: 746 EARNV---------------FGKVQAEARLIV---TGHAPPQIASSAPTVRVLEGQ---- 783
A N F + + E +LI+ T A A + + GQ
Sbjct: 1631 TAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWE 1690
Query: 784 ----------------------------PVSLPC-IVLAGRPLPERHWLKDGRPLPPGSR 814
P C + G P WL DG+PL +R
Sbjct: 1691 EGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR 1750
Query: 815 -HSIRADGSLHLDR--ALQEHAGRYSCVATNTAGSQHRDVELVV----------QVPP-- 859
I G LD A +G +C ATN G+ H L+V Q+P
Sbjct: 1751 LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGR 1810
Query: 860 -----------RIHPTATHHITN--------------------EGVPASLPCVASGVPAP 888
H A +T EG A C +G P P
Sbjct: 1811 KGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQP 1870
Query: 889 TITWTKETNALTSRGPHYNVSKEGT--LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+ W L + + V +G L I + D G TA N G +++L +
Sbjct: 1871 KVNWYL-NGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEI 1929
Query: 947 NTK 949
+
Sbjct: 1930 QQR 1932
Score = 64.7 bits (156), Expect = 5e-10
Identities = 107/546 (19%), Positives = 208/546 (38%), Gaps = 60/546 (10%)
Query: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT---DPPPQLVPAP 407
G+ + ++ G EI + ++ G Y CT + AG+ + ++ + D Q V
Sbjct: 32896 GKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQ 32955
Query: 408 NVT-VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 466
+ ++P + AV+ + +A +R + + +LA L E S ++ ++
Sbjct: 32956 KTSEITPQKKAVVQEEISQKA------LRSEEIKMSEAKSQEKLA-LKEEASKVLISEEV 33008
Query: 467 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV----KVSCSASGYPTPHI 522
+ S + + + + +V H + FS + + ++ A+ +
Sbjct: 33009 KKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDV 33068
Query: 523 SWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQ----ETVTL 575
W L G TL I+ + D G +C + + G + T++
Sbjct: 33069 KWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK 33128
Query: 576 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---- 631
+D P+ + + G+ + CE SG P P + W++ L + ++ S S
Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNV 33188
Query: 632 -KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690
L I A D+G YT +A N G SA L V P + E R+V +
Sbjct: 33189 YSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV--LPLVEEPSREVVL---------- 33236
Query: 691 RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV--LFFESVAPED----QAPYV 744
R +G ++ Q + A S S S + + F S++ + Q +V
Sbjct: 33237 RTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFV 33296
Query: 745 CEARNVFGKV-------QAEARLIVTG--HAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 795
+ + F + + ++++ G PP+I + + + EG+ +++ C G
Sbjct: 33297 EMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVAC-AFTGE 33355
Query: 796 PLPERHWLKDGRPL---PPGSRHSIRADG--SLHLDRALQEHAGRYSCVATNTAGSQHRD 850
P PE W GR + G H D +L + ++ G Y+ N GS
Sbjct: 33356 PTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSAT 33415
Query: 851 VELVVQ 856
V + ++
Sbjct: 33416 VNIHIR 33421
Score = 63.9 bits (154), Expect = 9e-10
Identities = 109/467 (23%), Positives = 166/467 (35%), Gaps = 55/467 (11%)
Query: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH----VDAQGT 544
EAP++ SQ QG + G P P W + ++ RI+ D
Sbjct: 2076 EAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE 2135
Query: 545 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE---AVLV 601
L+I+ V ED+ + +A N G L ++ + V E+ A
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2195
Query: 602 CEASGVPPPRVIWYRGGLEMILAPEGS-----SSGK---LRIPAAQERDAGTYTCRAVNE 653
CE S P +V WY+ G+E+ EG S K L I DA Y+C V +
Sbjct: 2196 CETS-EPFVKVKWYKDGMEV---HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVED 2251
Query: 654 LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV--TWRRGDGQPLG 711
+ + G + + +D+ V S L C + P + W D +
Sbjct: 2252 ENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKS 2308
Query: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY--VCEARNVFGKVQAEARLIVTGHAPPQ 769
R RQ L + V EDQ Y V + + K++ + R P
Sbjct: 2309 NGKYTITSRRGRQN----LTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPR-------PIA 2357
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH---LD 826
I +V EG V L V E W+KDG+ + P R I D H ++
Sbjct: 2358 ILQGLSDQKVCEGDIVQLE--VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2415
Query: 827 RALQEHAGRYS----CVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 882
+E AG YS + +T+G + V I P ++ EG A L C
Sbjct: 2416 DMTKEDAGNYSFTIPALGLSTSG------RVSVYSVDVITPLKDVNVI-EGTKAVLECKV 2468
Query: 883 SGVPAPTITWTKETNALTSRGPHYNVSK--EGTLLIAQPSAQDAGAY 927
S ++ W + + K + L+I + A D G Y
Sbjct: 2469 SVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2515
Score = 60.5 bits (145), Expect = 1e-08
Identities = 117/571 (20%), Positives = 186/571 (32%), Gaps = 115/571 (20%)
Query: 651 VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-- 708
V E A +++ V P L ++VTV G S L C +G P PTVTW R D Q
Sbjct: 926 VTETARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIE 984
Query: 709 -----PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
+ + G R L ED + C A N G V L V
Sbjct: 985 SSIDFQITFQSGIAR-----------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Query: 764 --------------------------------------------GHAPPQIASSAPTVRV 779
A P + ++
Sbjct: 1034 VSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKL 1093
Query: 780 LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSI-----RADGSLHLDRALQEHAG 834
+EG V C V G P P +W K G PL G R+ + + L + + AG
Sbjct: 1094 VEGGSVVFGCQV-GGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAG 1152
Query: 835 RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWT 893
Y+ V N G L+ + + + + + V A + G AP ++
Sbjct: 1153 EYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYS 1212
Query: 894 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIH 953
+ ++ + +D ++ + + + + + +
Sbjct: 1213 EYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLE 1272
Query: 954 MNGSRNANVPLQVTAKA---------------GEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
+G V + + G VT C+ G P P + W KD + +
Sbjct: 1273 EDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1332
Query: 999 PITNRYGL--LPSG--SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQS 1054
RY + L G SLR+ V D G Y ASN G+A G+ +P +
Sbjct: 1333 H-GERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAI------CSGKLYVEPAA 1385
Query: 1055 -LPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSSSTLSL 1113
L P + +P L+P R+ LS R+ P + +S A +S + +S
Sbjct: 1386 PLGAPTY--------IPTLEPVS---RIRSLSPRSVSRSPIRMSPARMSPARMSPARMS- 1433
Query: 1114 HLSPYPLR-GPGDAVQRPPTTQGRAQWGPGF 1143
P R PG ++ +Q + P F
Sbjct: 1434 -----PARMSPGRRLEETDESQLERLYKPVF 1459
Score = 59.7 bits (143), Expect = 2e-08
Identities = 78/293 (26%), Positives = 111/293 (37%), Gaps = 31/293 (10%)
Query: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727
AP E R++ V +A L C+ TG P P V W R G+ + + G R ++
Sbjct: 30927 APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEI---IADGLKYRIQEFKG 30982
Query: 728 GV--LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP---PQIASSAPTVRVLEG 782
G L SV +D Y A N G V A L V A P+ V L G
Sbjct: 30983 GYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRG 31042
Query: 783 QPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH----SIRADGSLHLDRALQ-EHAGRYS 837
+ VS+ I +G+P P W K G+ L + H R+ SL ++ + AG Y
Sbjct: 31043 EVVSIK-IPFSGKPDPVITWQK-GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYV 31100
Query: 838 CVATNTAGSQHRDVEL-VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
A N G + VEL V VP ++ + V +TWT+
Sbjct: 31101 VCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSV--------------NLTWTEPA 31146
Query: 897 NALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
+ S+ +Y V K T A T N G +S + R+ K
Sbjct: 31147 SDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENK 31199
Score = 57.8 bits (138), Expect = 6e-08
Identities = 118/549 (21%), Positives = 199/549 (36%), Gaps = 52/549 (9%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGT 387
CS+ S F +Q +R + L + + +L A + GTY V G
Sbjct: 12573 CSI-SKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTY----VVMVGA 12627
Query: 388 GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV 447
RA A + V + +VP + V + V +C V E W R+ + S+ +
Sbjct: 12628 ARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGA-KAKWFRNEEAIFDSSKYI 12686
Query: 448 AQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQG 505
DL +L I D Y +N G S L+ E + I +
Sbjct: 12687 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETM 12746
Query: 506 VEVKVS--CSASGYPTPHISWSRESQALQEDSRI--HVDA-QGTLIIQGVAPEDAGNYSC 560
+ V+ C + + W++ + + D+R+ VD + L I+ D G Y
Sbjct: 12747 EKKSVTFWCKVNRLNVT-LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 12805
Query: 561 QATNEVGTDQETVTLYYTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
A G D+ L + P+ + V ++AV C+ S V WYR G
Sbjct: 12806 TA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGR 12860
Query: 620 EM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTE 673
E+ + S +L I + D Y C + D + +L V P ++
Sbjct: 12861 EIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACG----VEDRKSRARLFVEEIPVEIIR 12916
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF-- 731
P+D+ G + + V W R + + +G + + G +
Sbjct: 12917 PPQDILEAPGADVVFLAELN-KDKVEVQWLRNN-------MVVVQGDKHQMMSEGKIHRL 12968
Query: 732 -FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
+ P DQ Y A++ EAR + A P+I ++ + V G+P+++ +
Sbjct: 12969 QICDIKPRDQGEYRFIAKD------KEARAKLELAAAPKIKTADQDLVVDVGKPLTM-VV 13021
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD 850
P E W K+ PL + + S + A + GRY V N G
Sbjct: 13022 PYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGF 13081
Query: 851 VEL-VVQVP 858
+ L V+ VP
Sbjct: 13082 INLKVIDVP 13090
Score = 57.4 bits (137), Expect = 8e-08
Identities = 124/549 (22%), Positives = 196/549 (35%), Gaps = 86/549 (15%)
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS----------GV 607
+ +A NE G + + T + V + +G + LVC+A G
Sbjct: 15779 FRVKAVNEAGESEPSDTTGEIPATDIQE-EPEVFIDIGAQDCLVCKAGSQIRIPAVIKGR 15837
Query: 608 PPPRVIWYRGGLEMILAPEG-------------SSSGKLRIPAAQERDAGTYTCRAVNEL 654
P P+ W G +G +S + IP + G Y+ A N+
Sbjct: 15838 PTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKA 15897
Query: 655 GDASAEIQLAVGHAPQLTELPRDVTV-ELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713
G +A ++ V P P+D+ V ++ R + CR + + P R G + R
Sbjct: 15898 GQKTANCRVKVMDVPGP---PKDLKVSDITRGS---CRLSWKMPDDDGGDRIKGYVIEKR 15951
Query: 714 LGAGRGSRSRQPDSGVLFF--ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
G+ PD G F + E Q + A N FG + I A I
Sbjct: 15952 TIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFG-IGPPVETIQRTTARDPIY 16010
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRP------LPERHWLKDGRPLPP-GSRHSIRADGSLH 824
P +++ G ++ + L+ +P P H++ + P G++ +
Sbjct: 16011 PPDPPIKLKIGL-ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKR 16069
Query: 825 LDRALQ------EHAGRYS--CVATNTAGSQHRDVELVV------QVPPRIHPTATHHIT 870
LQ G Y A N AG + +PP I +
Sbjct: 16070 DVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV- 16128
Query: 871 NEGVPASLPCVASGVPAPTITWTK------ETNALTSRGPHYN---VSKEGTLLIAQPSA 921
EG ++ GVP PT+TW K + H N V TL+I Q
Sbjct: 16129 EEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRR 16188
Query: 922 QDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAK 981
D G Y TA N +G +S+EMRL+V +P + P++ + + +++TL
Sbjct: 16189 SDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVG-------PIKFESVSADQMTL----S 16237
Query: 982 GSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
PP KD ITN Y + + R V V S ECT + P H YV
Sbjct: 16238 WFPP------KDDGG-SKITN-YVIEKREANRKTWVHV-SSEPKECTYTIPKLLEGHEYV 16288
Query: 1042 LGVQGRTSW 1050
+ + +
Sbjct: 16289 FRIMAQNKY 16297
Score = 57.0 bits (136), Expect = 1e-07
Identities = 139/689 (20%), Positives = 233/689 (33%), Gaps = 74/689 (10%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAVLSCRVLGEAPYNL 431
+E Y C T R + V + N+ VS +T L C V +
Sbjct: 12439 DEAEYSC----EVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVI 12494
Query: 432 TWVRDWRVLPASTGRVAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
+ D ++ TGR L + L I D G Y C ++ + V L
Sbjct: 12495 WYKGDEEII--ETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAA 12552
Query: 489 E---APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG-- 543
E PQ + +G + + CS S P + W R+ + L+ + V A G
Sbjct: 12553 EFISKPQ------NLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKK 12605
Query: 544 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
L+++ +D G Y VG + L + + V +E V C
Sbjct: 12606 RVLVVKDATLQDMGTYVVM----VGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNC 12661
Query: 603 EASGVPPPRVIWYRGGLEMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELGD- 656
E + + W+R + + + K LRI A D Y N G+
Sbjct: 12662 EVN-TEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGEN 12720
Query: 657 -ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRL 714
SA + ++ E +D+ +S C+ R T+ W + G+ P R+
Sbjct: 12721 VKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVN-RLNVTLKWTKNGEEVPFDNRV 12779
Query: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
S +L + D+ Y+ A G+ ++ A L++ AP +
Sbjct: 12780 -----SYRVDKYKHMLTIKDCGFPDEGEYIVTA----GQDKSVAELLII-EAPTEFVEHL 12829
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH----LDRALQ 830
V E C + R W ++GR + G ++ DGS+H D L
Sbjct: 12830 EDQTVTEFDDAVFSCQL--SREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLD 12887
Query: 831 EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTI 890
+ Y+C + VE ++P I + G +
Sbjct: 12888 DEC-EYACGVEDRKSRARLFVE---EIPVEIIRPPQDILEAPGADVVF-LAELNKDKVEV 12942
Query: 891 TWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947
W + N + +G + + EG L I +D G Y A + +L +
Sbjct: 12943 QWLR-NNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKD----KEARAKLELA 12997
Query: 948 TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL 1007
P+I + A+ L V G+ +T+ P W K++ P+ T
Sbjct: 12998 AAPKI-----KTADQDLVV--DVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTID-TTA 13049
Query: 1008 PSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
S R+ + + GD G Y+ N G A
Sbjct: 13050 EQTSFRILEAKKGDKGRYKIVLQNKHGKA 13078
Score = 56.2 bits (134), Expect = 2e-07
Identities = 55/183 (30%), Positives = 76/183 (41%), Gaps = 15/183 (8%)
Query: 598 AVLVCEASGVPPPRVIWYRGGLEMI-------LAPEGSSSGKLRIPAAQERDAGTYTCRA 650
A LVC+ +G P P V WYR G E+I + +L I + + DA Y RA
Sbjct: 30945 ATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRA 31004
Query: 651 VNELGDASAEIQLAVG-----HAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRG 705
N+ G S L V H P+ E V G + +G+P P +TW++
Sbjct: 31005 TNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQK- 31063
Query: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 765
GQ L G + +R S ++F V +D YV A+N FG Q L V
Sbjct: 31064 -GQDLIDNNGHYQVIVTRSFTS-LVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADV 31121
Query: 766 APP 768
P
Sbjct: 31122 PDP 31124
Score = 54.7 bits (130), Expect = 5e-07
Identities = 141/732 (19%), Positives = 248/732 (33%), Gaps = 103/732 (14%)
Query: 387 TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA--PYNLTWVRDWRVLPAST 444
T K Q + PP++ S E A L+C V +TW +D + L +
Sbjct: 32704 TPTEKVQHLPVSAPPKITQFLKAEASK-EIAKLTCVVESSVLRAKEVTWYKDGKKLKENG 32762
Query: 445 G---RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL--------------- 486
+ L+I+ + +D G Y C S G ++ ++ +
Sbjct: 32763 HFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKIS 32822
Query: 487 -------------------------VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH 521
+ P + S K + A+G P P
Sbjct: 32823 ETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPT 32882
Query: 522 ISWSRESQALQEDSRIHV--DAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
W+++ +A+ + + + D G + I D+G Y+C N G+ + L
Sbjct: 32883 AIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Query: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLR---- 634
A V+ + + + + V + E I E S KL
Sbjct: 32943 AIKDTEAQK----VSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEE 32998
Query: 635 -----IPAAQERDAGTYTCRAV-----NELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684
I ++ A T +++ + AS E++ HA ++ +++ G+
Sbjct: 32999 ASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRT---HA-EIKAFSTQMSINEGQ 33054
Query: 685 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPY 743
+L G V W G+ L R S L + + D+
Sbjct: 33055 RLVLKANIAGATD--VKWVLN-----GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGIL 33107
Query: 744 VCEARNVFGKVQAEARLIVTGHAP--PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH 801
C ++ G V+ + L ++ P S + + EGQ V C + +G P PE
Sbjct: 33108 TCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEI-SGEPSPEIE 33166
Query: 802 WLKDGRPLPPGSRHSI---RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
W K+ P+ S SI R SL + A +G+Y+ A N G L+V
Sbjct: 33167 WFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-- 33224
Query: 859 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETN--ALTSRGPHYNVSKEGTLLI 916
P + + + SL S +E + + +S + +
Sbjct: 33225 PLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMS 33284
Query: 917 AQPSAQDAGAYV-CTATNTVGFSSQ---EMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
AQ + ++V ++++ +G S+ E S K I + +P ++ G+
Sbjct: 33285 AQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGK 33344
Query: 973 EVTLDCEAKGSPPPLVTWTKDSRPVPP-------ITNRYGLLPSGSLRLAQVQVGDSGHY 1025
+T+ C G P P VTW+ R + I N L +L + VQ D G Y
Sbjct: 33345 VLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT---TLIIMDVQKQDGGLY 33401
Query: 1026 ECTASNPAGSAS 1037
+ N GS S
Sbjct: 33402 TLSLGNEFGSDS 33413
Score = 54.3 bits (129), Expect = 7e-07
Identities = 119/508 (23%), Positives = 189/508 (37%), Gaps = 80/508 (15%)
Query: 523 SWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVT--LYY 577
+W ++ ++E + A G L I V DAG Y+C +G ++T T L
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVL--RLGNKEKTSTAKLVV 11207
Query: 578 TDPPS--VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---- 631
+ P V + V V G+ L CE + V+W + G ++ P G
Sbjct: 11208 EELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGL 11265
Query: 632 --KLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
L I A + DAGTYT N + S+ +++ L + RD V+ +A+
Sbjct: 11266 MRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIF 11325
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS---RQPDSGVLFFESVAPEDQAPYVC 745
AC + P + W +G + + A ++ R + L ++ PED A Y
Sbjct: 11326 AC-DIAKDTPNIKWFKGYDE-----IPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAV 11379
Query: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
E + GK + A+L + G ++ V + E + S ++ +P + W
Sbjct: 11380 E---IEGK-RYPAKLTL-GEREVELLKPIEDVTIYEKESASFDA-EISEADIPGQ-WKLK 11432
Query: 806 GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATN---TAGSQHRDVELVVQVPP 859
G L P I+A+G L L + + AG A N TA +++EL VP
Sbjct: 11433 GELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPL 11492
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVS---------- 909
+ E A CV T+E N + S+GP S
Sbjct: 11493 K------DVTVPERRQARFECVL----------TREANVIWSKGPDIIKSSDKFDIIADG 11536
Query: 910 KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSR-NANVPLQ-VT 967
K+ L+I D G Y T R+ + G R PL+ T
Sbjct: 11537 KKHILVINDSQFDDEGVYTAEVEGK------------KTSARLFVTGIRLKFMSPLEDQT 11584
Query: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSR 995
K GE T CE +V + D++
Sbjct: 11585 VKEGETATFVCELSHEKMHVVWFKNDAK 11612
Score = 54.3 bits (129), Expect = 7e-07
Identities = 60/228 (26%), Positives = 87/228 (38%), Gaps = 34/228 (14%)
Query: 482 SVWLLVRE--APQVSIHTSSQHFSQGVE---------VKVSCSASGYPTPHISWSRESQA 530
S W + E P+ + + HF + + + C +G+P P + W R+ +
Sbjct: 30908 SEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKE 30967
Query: 531 LQEDS---RIHVDAQG--TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP----- 580
+ D RI G LII V +DA Y +ATN+ G+ T +L P
Sbjct: 30968 IIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHL 31027
Query: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG-------GLEMILAPEGSSSGKL 633
P V GE + SG P P + W +G G ++ +S L
Sbjct: 31028 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS--L 31085
Query: 634 RIPAAQER-DAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTV 680
P ER DAG Y A N G ++L V P + PR V V
Sbjct: 31086 VFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVP---DPPRGVKV 31130
Score = 53.9 bits (128), Expect = 9e-07
Identities = 50/184 (27%), Positives = 80/184 (43%), Gaps = 16/184 (8%)
Query: 872 EGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVS-KEGTLLIAQPSAQDA--GAY 927
EG A+ SG P P ++W ++ + TS P +S +G + P+ A G Y
Sbjct: 19 EGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRY 78
Query: 928 VCTATNTVG--FSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP 985
ATN G S+ E+ + T P + ++ +T + G +V L G P
Sbjct: 79 SLKATNGSGQATSTAELLVKAETAPPNFVQRLQS------MTVRQGSQVRLQVRVTGIPT 132
Query: 986 PLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVGDSGHYECTASNPAGSASHRYVL 1042
P+V + +D + + + + G SL +A+ DSG Y A+N G A+ L
Sbjct: 133 PVVKFYRDGAEIQSSLD-FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAEL 191
Query: 1043 GVQG 1046
VQG
Sbjct: 192 LVQG 195
Score = 53.9 bits (128), Expect = 9e-07
Identities = 53/220 (24%), Positives = 81/220 (36%), Gaps = 10/220 (4%)
Query: 836 YSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE 895
Y C T + D +++ PP + G + P P +TW K
Sbjct: 31667 YYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKS 31726
Query: 896 TNALTSRGPHYNVSKEGT-----LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
+ + E L I + D Y A N G S + +L+V P
Sbjct: 31727 GQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHP 31786
Query: 951 RIHMNGSRNANVPLQVTAKA--GEEVTLDCEAKGSPPPLVTWTKDSRPV---PPITNRYG 1005
+ R L A+ G+ V + G PPP + W KD +P+ P I +
Sbjct: 31787 PPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE 31846
Query: 1006 LLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
L +L + D+G+Y TA+N AGS S + L V+
Sbjct: 31847 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 53.5 bits (127), Expect = 1e-06
Identities = 58/257 (22%), Positives = 86/257 (33%), Gaps = 46/257 (17%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV--------------------- 396
E G + + +K ++GTY C V+ G + A++ V
Sbjct: 31620 EDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRR 31679
Query: 397 TD-------PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVA 448
TD PP +P N T GE + ++TW + ++ P +
Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKY 31739
Query: 449 QLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF-- 502
L I+ + D Y VA N G L V P + T F
Sbjct: 31740 TFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKR 31799
Query: 503 -------SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG----TLIIQGVA 551
+G V SG P P + W ++ Q L I + +G L I+
Sbjct: 31800 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 31859
Query: 552 PEDAGNYSCQATNEVGT 568
PED G Y ATN G+
Sbjct: 31860 PEDTGYYRVTATNTAGS 31876
Score = 53.1 bits (126), Expect = 2e-06
Identities = 124/593 (20%), Positives = 221/593 (37%), Gaps = 82/593 (13%)
Query: 370 SKAEEGTYECT--AVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427
+K + G Y T A+ + +GR V + P +V V G AVL C+V
Sbjct: 2418 TKEDAGNYSFTIPALGLSTSGRVSVYSVDV-----ITPLKDVNVIEGTKAVLECKVSVPD 2472
Query: 428 PYNLTW-VRDWRVLPAS-TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV-- 483
++ W + D ++ P + + L I+ +D G Y+ + SV
Sbjct: 2473 VTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK 2532
Query: 484 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG 543
++R ++ +Q V +V S SG + W+ + + ++ S+ ++A G
Sbjct: 2533 IKIIRGLRDLTCTE-----TQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYKIEAHG 2584
Query: 544 ---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
L + + +D G Y+ A + + + TV P VA +EAV
Sbjct: 2585 KIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQT-----VAESQEAVF 2639
Query: 601 VCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
CE + P + W R G + I + +L I A + D G YT +
Sbjct: 2640 ECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKT 2698
Query: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLG 715
A +++ A ++ + +++TV + A+ T V W ++ G
Sbjct: 2699 SAKLKVE-----AVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQW---------IKNG 2744
Query: 716 AGRGSRSRQPDS--GVLF---FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQI 770
S + S G ++ ++ A D++ Y G++ A ARL V +I
Sbjct: 2745 VVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFR----LGRLGASARLHV---ETVKI 2797
Query: 771 ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH---LDR 827
V LE V+ + ++ +P + W + P +H + ++ +H L
Sbjct: 2798 IKKPKDVTALENATVAFE-VSVSHDTVPVK-WFHKSVEIKPSDKHRLVSERKVHKLMLQN 2855
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVP----ASLPCVAS 883
AG Y+ V G +L V+ +H T T + N VP AS C S
Sbjct: 2856 ISPSDAGEYTAV----VGQLECKAKLFVET---LHITKT--MKNIEVPETKTASFECEVS 2906
Query: 884 GVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATN 933
P++ W K + + +G L+I S +D+ Y N
Sbjct: 2907 HFNVPSM-WLK-NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957
Score = 53.1 bits (126), Expect = 2e-06
Identities = 79/358 (22%), Positives = 129/358 (36%), Gaps = 64/358 (17%)
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 733
L V + G + GRPPPTVTWR+ D + LG R S S +L
Sbjct: 27277 LRTSVIAKAGEDVQVLIPFKGRPPPTVTWRK-DEKNLG---SDARYSIENTDSSSLLTIP 27332
Query: 734 SVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLA 793
V D Y+ N G+ ++ + ++ + + L+ + VS + L
Sbjct: 27333 QVTRNDTGKYILTIENGVGEPKSSTVSV-------KVLDTPAACQKLQVKHVSRGTVTLL 27385
Query: 794 GRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGR---YSCVATNTAGSQHRD 850
P PL G GS ++ +++ +S V+ + + +
Sbjct: 27386 WDP-----------PLIDG--------GSPIINYVIEKRDATKRTWSVVSHKCSSTSFKL 27426
Query: 851 VELVVQVPPRIHPTATHHI-TNEGVPASLPCVASGVPAPT--------------ITWTKE 895
++L + P A + I E + P A+ VPAP ++WTK
Sbjct: 27427 IDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKP 27486
Query: 896 --------TNALTSRG-------PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 940
T + R H +SK + ++Q Q + A N G S
Sbjct: 27487 DFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 27546
Query: 941 EMRLSVNTKPRIHMNGSRNANVP-LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
+ K I +++P QVT + G V L+ KG P P ++W KD P+
Sbjct: 27547 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPL 27604
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/121 (30%), Positives = 54/121 (44%), Gaps = 6/121 (4%)
Query: 876 ASLPCVASGVPAPTITWTKETNALTSRGPHYNVS--KEG--TLLIAQPSAQDAGAYVCTA 931
A+L C +G P P + W ++ + + G Y + K G L+IA + DA Y A
Sbjct: 30945 ATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRA 31004
Query: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT 991
TN G S L V +IH+ + V A GE V++ G P P++TW
Sbjct: 31005 TNQGGSVSGTASLEVEVPAKIHL--PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ 31062
Query: 992 K 992
K
Sbjct: 31063 K 31063
Score = 52.8 bits (125), Expect = 2e-06
Identities = 158/688 (22%), Positives = 255/688 (37%), Gaps = 118/688 (17%)
Query: 392 AQIVVTDPPPQL-VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL 450
AQ+ V + P V + T + L C V + P + W +D + S +
Sbjct: 11654 AQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVP--VKWFKDGEEIVPSPKYSIKA 11711
Query: 451 ADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVR----EAPQVSIHT---SSQH 501
L L+I D G Y C T+A+V + R E P + + H
Sbjct: 11712 DGLRRILKIKKADLKDKGEYVCDCGTDK--TKANVTVEARLIKVEKPLYGVEVFVGETAH 11769
Query: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQ--------EDSRIHVDAQGTLIIQGVAPE 553
F E+++S P H W + Q L ED + H+ LI+
Sbjct: 11770 F----EIELS-----EPDVHGQWKLKGQPLTASPDCEIIEDGKKHI-----LILHNCQLG 11815
Query: 554 DAGNYSCQATNEVGTDQ---ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 610
G S QA N + + L + P S V V +EA CE S P
Sbjct: 11816 MTGEVSFQAANAKSAANLKVKELPLIFITPLSD------VKVFEKDEAKFECEVSR-EPK 11868
Query: 611 RVIWYRGGLEMI------LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 664
W +G E+ L +G+ + I +A D Y A ++ S ++ +
Sbjct: 11869 TFRWLKGTQEITGDDRFELIKDGTKHSMV-IKSAAFEDEAKYMFEAEDK--HTSGKLIIE 11925
Query: 665 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG-SRSR 723
LT L +DVT + SA+ + V W + D RL R S
Sbjct: 11926 GIRLKFLTPL-KDVTAKEKESAVFTVELS-HDNIRVKWFKNDQ-----RLHTTRSVSMQD 11978
Query: 724 QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 783
+ + + F+ ++ +D + EA + +EA+L V P +E
Sbjct: 11979 EGKTHSITFKDLSIDDTSQIRVEAMGM----SSEAKLTVL-EGDPYFTGKLQDYTGVEKD 12033
Query: 784 PVSLPC-IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYS-- 837
V L C I A P+ W KDG+ + P I+ADG L L +AL+ G+Y+
Sbjct: 12034 EVILQCEISKADAPVK---WFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 12090
Query: 838 CVATNTAGS---QHRDVELV-----VQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
C T+G + R+++LV V+V I+ + + A+
Sbjct: 12091 CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHAN------------ 12138
Query: 890 ITWTKETNALTSRGPHYNVSKEGTL--LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947
W + AL + P + +EG + L+ D T V F + ++ S +
Sbjct: 12139 --WKLKGEALL-QTPDCEIKEEGKIHSLVLHNCRLD-------QTGGVDFQAANVKSSAH 12188
Query: 948 TKPRIHMNGSRNANVPLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP---ITNR 1003
+ + + G PL+ VT AGE T DCE P+ + K + P +
Sbjct: 12189 LRVKPRVIGLLR---PLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRS 12245
Query: 1004 YGLLPSGSLRLAQVQVGDSGHYECTASN 1031
G + +L L V++ D+G + TA +
Sbjct: 12246 EGKV--HTLTLRDVKLEDAGEVQLTAKD 12271
Score = 52.8 bits (125), Expect = 2e-06
Identities = 86/400 (21%), Positives = 148/400 (37%), Gaps = 34/400 (8%)
Query: 487 VREAPQVSIHTS---SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---D 540
+ EAP++ + + S G +V+V G P P ++W ++ + L D+R + D
Sbjct: 27265 ILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTD 27324
Query: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
+ L I V D G Y N VG + TV++ D P+ V V+ G +
Sbjct: 27325 SSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTL 27384
Query: 600 L----VCEASGVPPPRVIWYRGGLEMI--LAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 653
L + + VI R + + SS ++ E+ + A NE
Sbjct: 27385 LWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENE 27444
Query: 654 LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP--------PPTVTWRRG 705
+G A ++ RD++++ + T +P V R+G
Sbjct: 27445 IGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWT-KPDFDGGSVITEYVVERKG 27503
Query: 706 DGQPLGLRLGAGRGSR---SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
G+ G + S+ + VL F A ++ G + + +I
Sbjct: 27504 KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG---LSDPVTIGPITVKELIIT 27560
Query: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS--RHSIRAD 820
I + TVR+ + LP G+P P WLKDG PL R S +
Sbjct: 27561 PEVDLSDIPGAQVTVRIGHNVHLELP---YKGKPKPSISWLKDGLPLKESEFVRFSKTEN 27617
Query: 821 G-SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
+L + A +EH G+Y+ + N + ++ PP
Sbjct: 27618 KITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPP 27657
Score = 51.6 bits (122), Expect = 4e-06
Identities = 81/397 (20%), Positives = 140/397 (35%), Gaps = 56/397 (14%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM---ILAPEGSSSGKLRIPAAQERDAGTY 646
V + G L+ SG PPP + W + G+++ + S L + DAG Y
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 29515
Query: 647 TCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWR--- 703
T A N+ G SA + + V P G + + R T+TW
Sbjct: 29516 TIEAENQSGKKSATVLVKVYDTP-------------GPCPSVKVKEVSRDSVTITWEIPT 29562
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDS-----------------GVLFFESVAPED--QAPYV 744
G P+ + R + R + G +++ V PE+
Sbjct: 29563 IDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEP 29622
Query: 745 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTV---RVLEGQPVSLPCIVLAGRPLPERH 801
CE + + +E L+ + S T+ + L L VL
Sbjct: 29623 CETSDAV--LVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTER 29680
Query: 802 WLKDGRPLPPGSRHSIRA--DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
W+K P H++ + +G +L R ++ S +D+ ++ +
Sbjct: 29681 WMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDL 29740
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITW------TKETNALTSRGPHYNVSKEGT 913
P T H+ G P L +G P P +W +E+ +T H V+K
Sbjct: 29741 STMPQKTIHVP-AGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVE-THTKVAK--- 29795
Query: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
L I + + +D G Y N G +S+ +++ + KP
Sbjct: 29796 LTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Score = 51.2 bits (121), Expect = 6e-06
Identities = 136/651 (20%), Positives = 221/651 (33%), Gaps = 99/651 (15%)
Query: 374 EGTYECTAVSRAGTGRAKAQIVVTDPPPQL-----VPAPNVTVSPGETAVLSCRVLGEAP 428
E + +A +R GTG V TD P + VP P + V+ + + E P
Sbjct: 13159 EYLFRVSARNRVGTGEP----VETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPP 13214
Query: 429 -YN--------LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 479
Y+ + +RD + T + DLS ++ ++ ++ A N GV
Sbjct: 13215 EYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVG 13274
Query: 480 RASVWL--------LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 531
+ S + R +P V++ TSS V++K +P + + E
Sbjct: 13275 KPSAATPFVKVADPIERPSPPVNL-TSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEE 13333
Query: 532 QEDSRIHVDA----QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-------YYTDP 580
+D+ I + + T + G+ + Y A N+ G + L + +P
Sbjct: 13334 GKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEP 13393
Query: 581 P-SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL-----EMILAPEGSSSGKLR 634
+SA + V V ++ ++G P P W G + + S+ +L
Sbjct: 13394 TMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELV 13453
Query: 635 IPAAQERDAGTYTCRA------------VNELGDASAEIQLAVGHAPQ----LTELPRDV 678
I ++ D G YT + VN + SA +L G + LT P D
Sbjct: 13454 ISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPD- 13512
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ------------PD 726
+ G S L R TW + L + ++ P
Sbjct: 13513 --DDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPG 13570
Query: 727 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 786
E V A NV + + + +T P S ++E P
Sbjct: 13571 EPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRG 13630
Query: 787 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA-----DGSLHLDRALQEHAGRYSCVAT 841
V G P+ E G L G ++ R G+ R +E V T
Sbjct: 13631 SDKWVACGEPVAETKMEVTG--LEEGKWYAYRVKALNRQGASKPSRPTEE----IQAVDT 13684
Query: 842 NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 901
A DV+L+ + + G LP +G P P ITWTK L
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKA-----------GTKIELPATVTGKPEPKITWTKADMILKQ 13733
Query: 902 --RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
R NV K+ T+ I D G Y+ A N G ++ + ++V KP
Sbjct: 13734 DKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 51.2 bits (121), Expect = 6e-06
Identities = 56/242 (23%), Positives = 95/242 (39%), Gaps = 18/242 (7%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTG---RAKAQIVVTDP-----PPQLVPAPNV 409
E +S+ + E + TAV+ G G ++ +DP PP+ + +
Sbjct: 18751 EVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEM 18810
Query: 410 TVSPGETAVLSCRVLGEAPYN--LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 467
T + A L G A + +T R+ + + DLSL ++G+ +
Sbjct: 18811 TKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYK 18870
Query: 468 YQCVASNANGVTRASVWLLVREA-----PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 522
++ A NA GV+ V EA P + G ++++ G P P
Sbjct: 18871 FRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTC 18930
Query: 523 SWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 579
W + + S + V D+ LII+ V +D+G YS A N GTD + + + D
Sbjct: 18931 KWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 18990
Query: 580 PP 581
P
Sbjct: 18991 AP 18992
Score = 51.2 bits (121), Expect = 6e-06
Identities = 91/398 (22%), Positives = 145/398 (36%), Gaps = 52/398 (13%)
Query: 668 APQL---TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
AP+L +EL + + V G SA + GRP P +TW R +G+ ++ +G Q
Sbjct: 24021 APELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTD-KVQIEKGVNYTQ 24079
Query: 725 PDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQP 784
L ++ D Y+ + N G A + V P + VR
Sbjct: 24080 -----LSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFL 24134
Query: 785 VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA--LQEHAGRYSCVATN 842
V P I+ G + ++++ D R + ++ + S + L E A Y V
Sbjct: 24135 VWEPPIIDGGAKV--KNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAE 24192
Query: 843 TAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
VE V V P+ +T V + + ++ W K + SR
Sbjct: 24193 NEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQT---------SASLMWEKPEHDGGSR 24243
Query: 903 GPHYNVSKEGTLLIAQPSAQD-----AGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGS 957
Y V QP + A + VC A T S QE + V +
Sbjct: 24244 VLGYVVEM-------QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDP 24296
Query: 958 RNANVPL----------------QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
R VP+ + +AGE++ ++ G P P ++W KD P+ T
Sbjct: 24297 RVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT 24356
Query: 1002 --NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
N S L + + D G Y TA+N AG+A+
Sbjct: 24357 RVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 24394
Score = 50.8 bits (120), Expect = 8e-06
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LII 547
P + + ++ G ++K+ G P P+ISW ++ + L++ +R++V+ T L I
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 24371
Query: 548 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 607
+ +D G Y+ ATN GT E +++ + P V V V + V++ S
Sbjct: 24372 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPG-PPVGPVRFDEVSADFVVI---SWE 24427
Query: 608 PPPRVIWYRGGLEM 621
PP Y GG ++
Sbjct: 24428 PPA----YTGGCQI 24437
Score = 50.1 bits (118), Expect = 1e-05
Identities = 108/490 (22%), Positives = 175/490 (35%), Gaps = 50/490 (10%)
Query: 369 ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV-PAPNVTVSPGETAVLSCRVLGEA 427
A + GTY T + + VV LV P + V P TA+ +C + +
Sbjct: 11274 ADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDT 11333
Query: 428 PYNLTWVRDWRVLPASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
P N+ W + + +PA ++ L L+I +P D Y A +
Sbjct: 11334 P-NIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKR--YPAKL 11390
Query: 484 WLLVREAPQVS-IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L RE + I + + + S + P W + + L+ + A+
Sbjct: 11391 TLGEREVELLKPIEDVTIYEKESASFDAEISEADIPG---QWKLKGELLRPSPTCEIKAE 11447
Query: 543 GT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD-PPSVSAVNAVVLVAVGEEA 598
G L + V + AG QA N + T TV D + V E
Sbjct: 11448 GGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC 11507
Query: 599 VLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGK---LRIPAAQERDAGTYTCRAVN 652
VL EA+ VIW +G ++I + + + GK L I +Q D G YT
Sbjct: 11508 VLTREAN------VIWSKGP-DIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVE- 11559
Query: 653 ELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
G ++ G + D TV+ G +A C + V W + D
Sbjct: 11560 --GKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS-HEKMHVVWFKNDA----- 11611
Query: 713 RLGAGRGSR-SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
+L R S + + L + V +D + + + + Q + A P
Sbjct: 11612 KLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVL-----EADPYFT 11666
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG---SLHLDRA 828
+E ++L C V P+ W KDG + P ++SI+ADG L + +A
Sbjct: 11667 VKLHDKTAVEKDEITLKCEVSKDVPVK---WFKDGEEIVPSPKYSIKADGLRRILKIKKA 11723
Query: 829 LQEHAGRYSC 838
+ G Y C
Sbjct: 11724 DLKDKGEYVC 11733
Score = 50.1 bits (118), Expect = 1e-05
Identities = 90/416 (21%), Positives = 148/416 (35%), Gaps = 66/416 (15%)
Query: 524 WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV---TLYYTDP 580
W R + +D + V+ +GV P+ +A N +G + + + DP
Sbjct: 14331 WMRVNSRPIKDLKFKVE-------EGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 14383
Query: 581 ---PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGK 632
P++ ++V GE+ + VP P V W++ G E+ + S
Sbjct: 14384 DCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAH 14443
Query: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692
L +P + DAG YT N+LG A+A I + V P + ++ +C+
Sbjct: 14444 LEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCK-----DIKASDITKSSCKL 14498
Query: 693 TGRPPP---------TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
T PP V RR G+ + + +G S + + P + +
Sbjct: 14499 TWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLS-------WTVKDLIPNGEYFF 14551
Query: 744 VCEARN-VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL----- 797
+A N V G E + V P Q P V V P + + PL
Sbjct: 14552 RVKAVNKVGGGEYIELKNPVIAQDPKQ--PPDPPVDVEVHNPTAEAMTITWKPPLYDGGS 14609
Query: 798 ------------PERHWLKDGRPLPPGSRHSIRA--DGSLHLDRALQEHAGRYSCVATNT 843
E W + L P ++ + +G + R E+A S + T
Sbjct: 14610 KIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRAT 14669
Query: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNAL 899
++ D + P I T+ G +L SG P PTITW K+ N +
Sbjct: 14670 PPTKAVD---PIDAPKVILRTSLE--VKRGDEIALDASISGSPYPTITWIKDENVI 14720
Score = 49.7 bits (117), Expect = 2e-05
Identities = 32/134 (23%), Positives = 66/134 (49%), Gaps = 9/134 (6%)
Query: 457 ISGIIPTDGGRYQCVASNANGVT---RASVWLLVREA---PQVSIHTSSQHFSQGVEVKV 510
I+G+I + ++ A N G++ + SV ++ ++ P + ++ G ++KV
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 511 SCSASGYPTPHISWSRESQALQEDSRIHVDA---QGTLIIQGVAPEDAGNYSCQATNEVG 567
G PTP ++W +++ L++ +R++ ++ L I+ ED G+Y + TN G
Sbjct: 22168 DVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
Query: 568 TDQETVTLYYTDPP 581
ET+ + D P
Sbjct: 22228 EAIETLNVIVLDKP 22241
Score = 48.9 bits (115), Expect = 3e-05
Identities = 46/197 (23%), Positives = 82/197 (41%), Gaps = 20/197 (10%)
Query: 405 PAPNVTVSPGETAVLSCRVLGEAPYN------LTWVRDWRVLPASTGRVAQLADLSLEIS 458
P P V + + SC + + P++ + +V D+ RV + LSL+ S
Sbjct: 19884 PGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRV--MKSLSLQYS 19941
Query: 459 GIIPTDGGRY--QCVASNANGV-TRASVWLLVRE---APQVSIHTSSQHF---SQGVEVK 509
T+G Y + A N NG T + + ++ R+ AP + + + +
Sbjct: 19942 AKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFR 20001
Query: 510 VSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEV 566
+ G P P +SW + L D+R+ V++ TLI+ DAG Y+ N
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 567 GTDQETVTLYYTDPPSV 583
GT + T+++ P +
Sbjct: 20062 GTKEGTISIKVVGKPGI 20078
Score = 48.9 bits (115), Expect = 3e-05
Identities = 89/404 (22%), Positives = 157/404 (38%), Gaps = 51/404 (12%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 563
G ++ G P P++ WS+ L+ + + D++ +L I+ D+G Y+
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQ 26260
Query: 564 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL---VCEASGVPPPRV--IWYRGG 618
N + T+ + D P N V E AVL V E G P + I R
Sbjct: 26261 NVLSAASLTLVVKVLDTPG-PPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREA 26319
Query: 619 LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDV 678
+ ++ +L ++ Y R S E + VG P T+ +
Sbjct: 26320 SKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRV-------SGENEFGVG-IPAETKEGVKI 26371
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGD-----------------GQPLGLRLGAGRGSR 721
T + L + + ++TW + + GQ ++ + +
Sbjct: 26372 TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTH 26431
Query: 722 ---SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS---AP 775
S ++ FF A E+QA + + R + V + +L PP+I +
Sbjct: 26432 HVVSGLRENSEYFFRVFA-ENQAG-LSDPRELLLPVLIKEQL-----EPPEIDMKNFPSH 26484
Query: 776 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS--IRADG-SLHLDRALQEH 832
TV V G + + I ++G+PLP+ +DG PL R + I A+ +++L ++
Sbjct: 26485 TVYVRAGSNLKVD-IPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTAD 26543
Query: 833 AGRYSCVATNTAGSQHRDVELVV--QVPPRIHPTATHHITNEGV 874
AGRY A N++G+ + +VV + P P IT E V
Sbjct: 26544 AGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV 26587
Score = 48.9 bits (115), Expect = 3e-05
Identities = 37/126 (29%), Positives = 49/126 (38%), Gaps = 12/126 (9%)
Query: 870 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGA 926
T G A L C G P P I W + L + Y +S +G TL + +D G
Sbjct: 30544 TKLGEAAQLSCQIVGRPLPDIKWYRFGKELI-QSRKYKMSSDGRTHTLTVMTEEQEDEGV 30602
Query: 927 YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL--QVTAKAGEEVTLDCEAKGSP 984
Y C ATN VG +L + P+ H PL + G + L G P
Sbjct: 30603 YTCIATNEVGEVETSSKLLLQATPQFH------PGYPLKEKYYGAVGSTLRLHVMYIGRP 30656
Query: 985 PPLVTW 990
P +TW
Sbjct: 30657 VPAMTW 30662
Score = 48.1 bits (113), Expect = 5e-05
Identities = 53/229 (23%), Positives = 90/229 (39%), Gaps = 29/229 (12%)
Query: 735 VAPEDQAPYVCEARNVFGKV----QAEARLIVTGHAPPQIASSAPT----VRVLEGQPVS 786
++P D+ + ARN G + Q+ ++ P I P + + G+ +
Sbjct: 27918 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLR 27977
Query: 787 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR---ADGSLHLDRALQEHAGRYSCVATNT 843
+ +V GRP+P W KDG + I SL + A ++H G Y+ A N
Sbjct: 27978 IKALV-QGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNA 28036
Query: 844 AGSQHRDVELVVQVPPR--IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 901
+GS ++++ VQ P + P +IT E + T+ W N +
Sbjct: 28037 SGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKM--------------TLWWDAPLNDGCA 28082
Query: 902 RGPHYNVSKEGTLLIAQPSAQD-AGAYVCTATNTVGFSSQEMRLSVNTK 949
HY + K T +A +D A TA + + + R+S K
Sbjct: 28083 PITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNK 28131
Score = 47.8 bits (112), Expect = 6e-05
Identities = 33/96 (34%), Positives = 44/96 (45%), Gaps = 6/96 (6%)
Query: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR 1003
L+ N PRI ++ + + +T KAG V LD G P P V+W KD + P
Sbjct: 19287 LAENVPPRIDLSVAMKS----LLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI 19342
Query: 1004 YGLLPSG--SLRLAQVQVGDSGHYECTASNPAGSAS 1037
+ +L L V DSG Y TA N +GS S
Sbjct: 19343 KMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKS 19378
Score = 47.8 bits (112), Expect = 6e-05
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLII 547
P V SS G ++K+ SG P P I+W+++ L++ +RI+V TL I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 548 QGVAPEDAGNYSCQATNEVG---TDQETVTLYYTDPP 581
+ +D G Y N VG E VTL DPP
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPP 23326
Score = 47.4 bits (111), Expect = 8e-05
Identities = 34/148 (22%), Positives = 65/148 (43%), Gaps = 12/148 (8%)
Query: 450 LADLSLEISGIIPTDGGRYQCVASNANGVTRAS------VWLLVREAPQVSIHT---SSQ 500
+A+ +E++G+ Y+ A N G ++ S + +EAP++ + +
Sbjct: 13641 VAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGL 13700
Query: 501 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI---HVDAQGTLIIQGVAPEDAGN 557
G ++++ + +G P P I+W++ L++D RI +V + T+ I D G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGT 13760
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSA 585
Y +A N G V + D P A
Sbjct: 13761 YIIEAVNVCGRATAVVEVNVLDKPGPPA 13788
Score = 47.4 bits (111), Expect = 8e-05
Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 776 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEH 832
+++ E + +P I GRP P W+KDG PL +R ++ + LH+ ++
Sbjct: 24322 SIQAGEDLKIEIPVI---GRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDD 24378
Query: 833 AGRYSCVATNTAGSQHRDVELVVQVPP 859
G+Y+ ATN+AG+ ++ ++V P
Sbjct: 24379 FGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 47.0 bits (110), Expect = 1e-04
Identities = 38/164 (23%), Positives = 67/164 (40%), Gaps = 13/164 (7%)
Query: 450 LADLSLEISGIIPTDGGRYQCVASNANGV----TRASVWLLVREA---PQVSIHTSSQH- 501
+ D E++G++ ++ +A NA GV + ++ + R+ P++S+ +
Sbjct: 22493 IIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDT 22552
Query: 502 --FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAG 556
G KV G P P I W + Q L +R+ + D +L ++ D+G
Sbjct: 22553 IVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSG 22612
Query: 557 NYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
NY +A N G TV + D P V+ E+ L
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTL 22656
Score = 46.6 bits (109), Expect = 1e-04
Identities = 126/601 (20%), Positives = 211/601 (35%), Gaps = 53/601 (8%)
Query: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNV 409
+ R + + I+ ++ G Y C + A++VV + P + V V
Sbjct: 11163 KHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEV 11222
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ-LADL--SLEISGIIPTDGG 466
TV G+ LSC + E ++ W +D +++ GR+ + L +L I+ TD G
Sbjct: 11223 TVVKGQPLYLSCELNKER--DVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAG 11280
Query: 467 RYQCVASNANGVTRASVWLLVREAPQVSIH-TSSQHFSQGVEVKVSCSASGYPTPHISWS 525
Y NAN + +S +V + QH +C + TP+I W
Sbjct: 11281 TYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIA-KDTPNIKWF 11339
Query: 526 R--ESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 580
+ + + + + + G L I+ PED Y+ + E +TL +
Sbjct: 11340 KGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEI--EGKRYPAKLTLGEREV 11397
Query: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK-------L 633
+ + V + E A E S P +G L L P + K L
Sbjct: 11398 ELLKPIEDVTIYE-KESASFDAEISEADIPGQWKLKGEL---LRPSPTCEIKAEGGKRFL 11453
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEI-QLAVGHAPQLTELPRDVTVELGRSALLACRA 692
+ + AG +A+N + A + ++ + A L +DVTV R A C
Sbjct: 11454 TLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPL----KDVTVPERRQARFECVL 11509
Query: 693 TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 752
T V W +G + + + +L +D+ Y E V G
Sbjct: 11510 TRE--ANVIWSKGP----DIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAE---VEG 11560
Query: 753 KVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG 812
K + ARL VTG + S V EG+ + C + W K+ L
Sbjct: 11561 K-KTSARLFVTG-IRLKFMSPLEDQTVKEGETATFVCEL--SHEKMHVVWFKNDAKLHTS 11616
Query: 813 SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNE 872
I ++G H + S + V++ P E
Sbjct: 11617 RTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVE 11676
Query: 873 GVPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYV 928
+L C V+ VP + W K+ + P Y++ +G L I + +D G YV
Sbjct: 11677 KDEITLKCEVSKDVP---VKWFKDGEEIVP-SPKYSIKADGLRRILKIKKADLKDKGEYV 11732
Query: 929 C 929
C
Sbjct: 11733 C 11733
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 2/84 (2%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQV--GDSG 1023
V KAGE L+ + G PPP + W+KD + + + S L DSG
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSG 21530
Query: 1024 HYECTASNPAGSASHRYVLGVQGR 1047
Y TA+NP G A H + + V R
Sbjct: 21531 AYTLTATNPGGFAKHIFNVKVLDR 21554
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/78 (37%), Positives = 37/78 (47%), Gaps = 2/78 (2%)
Query: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLAQV 1017
+AN+ + K G+ + L KG P P VTW K+ R P R + P GS L +
Sbjct: 17221 DANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDA-PTKARIDVTPVGSKLEIRNA 17279
Query: 1018 QVGDSGHYECTASNPAGS 1035
D G Y T NPAGS
Sbjct: 17280 AHEDGGIYSLTVENPAGS 17297
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/142 (23%), Positives = 64/142 (45%), Gaps = 9/142 (6%)
Query: 449 QLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREA---PQVSIHTSSQHF 502
Q+ L ISG+ + ++ A N G + + V ++ R+ P V + + +
Sbjct: 25347 QVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNV 25406
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYS 559
++K+ G P ++W ++ Q L+E +R++V + T L I+ + ED G Y
Sbjct: 25407 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 560 CQATNEVGTDQETVTLYYTDPP 581
+N G+ +T+ D P
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRP 25488
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/79 (36%), Positives = 36/79 (45%), Gaps = 1/79 (1%)
Query: 873 GVPASLPCVASGVPAPTITWTKETNALTS-RGPHYNVSKEGTLLIAQPSAQDAGAYVCTA 931
G +P V +G P PT WTKE L R NV + L+I +D G YV TA
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITA 15178
Query: 932 TNTVGFSSQEMRLSVNTKP 950
TN+ G R+ V P
Sbjct: 15179 TNSCGSKFAAARVEVFDVP 15197
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 500 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNY 558
QH G +++S G P P ++W +E + +RI V G+ L I+ A ED G Y
Sbjct: 17228 QHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIY 17287
Query: 559 SCQATNEVGTDQETVTLYYTDPP 581
S N G+ +V + D P
Sbjct: 17288 SLTVENPAGSKTVSVKVLVLDKP 17310
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/72 (40%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRLAQVQVGDS 1022
V AKAGE+V + KG PPP VTW KD + + RY + + S L + QV D+
Sbjct: 27281 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGS-DARYSIENTDSSSLLTIPQVTRNDT 27339
Query: 1023 GHYECTASNPAG 1034
G Y T N G
Sbjct: 27340 GKYILTIENGVG 27351
Score = 44.7 bits (104), Expect = 5e-04
Identities = 57/211 (27%), Positives = 81/211 (38%), Gaps = 42/211 (19%)
Query: 782 GQPVSLP-CIVLAGRPLPERH--------------WLK---DGRPLPPGSRHSIRADGS- 822
G+P +P IV +P P R WLK DG G +R GS
Sbjct: 28531 GEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSD 28590
Query: 823 ------------LHLDRALQEHAGRYSCVATNTAG-SQHRDV-ELVVQVPPRIHPTAT-H 867
++R +++ + A N AG S+ R+ V+ P+I PTA
Sbjct: 28591 FWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLT 28650
Query: 868 HITNE------GVPASLPCVASGVPAPTITWTKETNAL--TSRGPHYNVSKEGTLLIAQP 919
ITN+ G P ++ SG PAP +TW E L T R TL +
Sbjct: 28651 GITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDS 28710
Query: 920 SAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
D+G Y T NT G + + + V +P
Sbjct: 28711 MRGDSGRYFLTLENTAGVKTFSVTVVVIGRP 28741
Score = 44.3 bits (103), Expect = 7e-04
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 487 VREAPQVSIHTSSQ---HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ- 542
+R P + + T Q H G V++ +G P P SW L+E R+ V+
Sbjct: 29732 LRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHT 29791
Query: 543 --GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
L I+ D G Y+ + N GT ET+ + D P
Sbjct: 29792 KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Score = 43.5 bits (101), Expect = 0.001
Identities = 153/756 (20%), Positives = 273/756 (36%), Gaps = 117/756 (15%)
Query: 357 QESGNSSWEILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGE 415
+ G+ I+ A+K ++ G Y + + + K + V + N+TV+ +
Sbjct: 2668 ESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK-----NLTVTETQ 2722
Query: 416 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVAS 473
AV + + + W+++ VL ++ + SL I D Y
Sbjct: 2723 DAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLG 2782
Query: 474 NANGVTRASVWL--LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 531
R V ++++ V T+ ++ + EV VS + T + W +S +
Sbjct: 2783 RLGASARLHVETVKIIKKPKDV---TALENATVAFEVSVS-----HDTVPVKWFHKSVEI 2834
Query: 532 QEDSRIHVDAQGT---LIIQGVAPEDAGNYS-------CQATNEVGTDQETVTLYYTDPP 581
+ + + ++ L++Q ++P DAG Y+ C+A V T T T+ + P
Sbjct: 2835 KPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVP 2894
Query: 582 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--SSGKLR---IP 636
+ A CE S P +W + G+E+ ++ + GKL I
Sbjct: 2895 ET------------KTASFECEVSHFNVPS-MWLKNGVEIEMSEKFKIVVQGKLHQLIIM 2941
Query: 637 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 696
D+ YT N+ A+ + + +T + +D+ E + +
Sbjct: 2942 NTSTEDSAEYTFVCGNDQVSATLTVTPIM-----ITSMLKDINAE-EKDTITFEVTVNYE 2995
Query: 697 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCEARNVFGKVQ 755
+ W + G+ + + + R + L +V D A Y V GK
Sbjct: 2996 GISYKWLKN-----GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTF----VAGKAT 3046
Query: 756 AEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH 815
+ A L V + ++VLE + C V P W+KD + L R
Sbjct: 3047 STATLYVEAR-HIEFRKHIKDIKVLEKKRAMFECEV--SEPDITVQWMKDDQELQITDRI 3103
Query: 816 SIRADGSLH---LDRALQEHAGRYSCVATNTAGS-----QHRDVEL-----VVQVPPRIH 862
I+ + +H + AG+Y+ VA + + RDV + VQV +
Sbjct: 3104 KIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQR 3163
Query: 863 PTATHHITNEGVPASLPCVASGVPAPTITWTK---ETNALTSRGPHYNVSKE-GTLLIAQ 918
+ + V A W K E N Y V + + I++
Sbjct: 3164 AVVEFEVNEDDVDAH--------------WYKDGIEINFQVQERHKYVVERRIHRMFISE 3209
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNT--KPRIHMNGSRNANVPLQ-VTAKAGEEVT 975
DAG Y T G + + L VN P++ LQ VT ++G+
Sbjct: 3210 TRQSDAGEY----TFVAGRNRSSVTLYVNAPEPPQVLQE--------LQPVTVQSGKPAR 3257
Query: 976 LDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVGDSGHYECTASNP 1032
G P P ++W K+ + + + L G +L L + D+ Y C A N
Sbjct: 3258 FCAVISGRPQPKISWYKEEQ-LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKND 3316
Query: 1033 AGSASHRYVLGVQGRTSWQP-QSLPVPHHPACLSGL 1067
G A+ L V+ P Q +PV + PA ++ L
Sbjct: 3317 YGVATTSASLSVEVPEVVSPDQEMPV-YPPAIITPL 3351
Score = 43.5 bits (101), Expect = 0.001
Identities = 93/412 (22%), Positives = 157/412 (38%), Gaps = 61/412 (14%)
Query: 579 DPPSV---SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSG 631
+PP + +++ +V+V G L G P P+V W + G++ ++ +
Sbjct: 18602 EPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMA 18661
Query: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTELP-RDVTVELGRSALLA 689
L IP + D+G Y+ VN G+ + + + V P +++L DVT +
Sbjct: 18662 FLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVT-------KTS 18714
Query: 690 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV--------LFFESVAPEDQA 741
C + PP DG + R+ S V ++ P ++
Sbjct: 18715 CHVSWAPP------ENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEY 18768
Query: 742 PYVCEARNVFGK-VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER 800
+ A N +G V + V P S R LE ++ LA P P R
Sbjct: 18769 YFRVTAVNEYGPGVPTDVPKPVLASDP---LSEPDPPRKLEVTEMTKNSATLAWLP-PLR 18824
Query: 801 -----------HWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG-SQH 848
+ ++ +P + +S+ D SL + + ++ A N G S
Sbjct: 18825 DGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLP 18884
Query: 849 RDVELVVQ-----VPPRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTK-ETNALTS 901
R+ E V + +PP+I IT G + G P PT W K E +TS
Sbjct: 18885 REAEGVYEAKEQLLPPKI--LMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTS 18942
Query: 902 RGPHYNVSK---EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
H V K L+I + +D+G Y TA N+ G +Q++++ V P
Sbjct: 18943 --SHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Score = 43.5 bits (101), Expect = 0.001
Identities = 37/137 (27%), Positives = 57/137 (41%), Gaps = 15/137 (10%)
Query: 649 RAVNELGDASAEIQ----LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRR 704
+ ++E ++ AEI+ + + +L + VT+ G S L +GRPPP +TW +
Sbjct: 29423 KGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSK 29482
Query: 705 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 764
Q + L A R +L + V D Y EA N GK A + V
Sbjct: 29483 ---QGIDL---ASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYD 29536
Query: 765 HAPPQIASSAPTVRVLE 781
P P+V+V E
Sbjct: 29537 TPGP-----CPSVKVKE 29548
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 23/157 (14%)
Query: 544 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD-----PPSV----SAVNAVVLVAV 594
+ +++ + + +A NE+G + ++ L PP++ S + V
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 15412
Query: 595 GEEAVLVCEASGVPPPRVIWYRG---------GLEMILAPEGSSSGK--LRIPAAQERDA 643
GE + + +G+P P++ W + L++ S K L IP A D
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 15472
Query: 644 GTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTV 680
GTYT A N LG + + V P PR++ V
Sbjct: 15473 GTYTVTASNRLGSVFRNVHVEVYDRP---SPPRNLAV 15506
Score = 43.1 bits (100), Expect = 0.002
Identities = 32/126 (25%), Positives = 52/126 (41%), Gaps = 20/126 (15%)
Query: 775 PTVR----VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA---DGSLHLDR 827
PT++ + G + L I + G+PLP+ W K G+ + P I + L +
Sbjct: 20382 PTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKY 20441
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
A ++ AG Y+ ATN G++ V++ V P G P +
Sbjct: 20442 ATRKDAGEYTITATNPFGTKVEHVKVTVLDVP-------------GPPGPVEISNVSAEK 20488
Query: 888 PTITWT 893
T+TWT
Sbjct: 20489 ATLTWT 20494
Score = 43.1 bits (100), Expect = 0.002
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 6/122 (4%)
Query: 931 ATNTVGFSSQEMRLS--VNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988
A N G+S S + +P+I +T KAG T+D G P P V
Sbjct: 28620 AKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKV 28679
Query: 989 TWTKDSRPVPPITNRYGLLPS---GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
TW + + T+R + + +L + GDSG Y T N AG + + V
Sbjct: 28680 TWKLEEMRLKE-TDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI 28738
Query: 1046 GR 1047
GR
Sbjct: 28739 GR 28740
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 563
G +++ S SG P P I+WS++ L + I ++ LI+ V DAG Y+ +A
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 29520
Query: 564 NEVGTDQETVTLYYTDPP 581
N+ G TV + D P
Sbjct: 29521 NQSGKKSATVLVKVYDTP 29538
Score = 42.7 bits (99), Expect = 0.002
Identities = 41/140 (29%), Positives = 59/140 (42%), Gaps = 19/140 (13%)
Query: 547 IQGVAPEDAGNYSCQATNEVGT----DQETVTLYYTD---PPSVSAVNAV---VLVAVGE 596
+ G++P D + A N VGT Q + + D PP V +++ GE
Sbjct: 27915 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 27974
Query: 597 EAVLVCEASGVPPPRVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCR 649
+ G P PRV W++ G+E+ I GS+S L + A G YT
Sbjct: 27975 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTS--LFVRDATRDHRGVYTVE 28032
Query: 650 AVNELGDASAEIQLAVGHAP 669
A N G A AEI++ V P
Sbjct: 28033 AKNASGSAKAEIKVKVQDTP 28052
Score = 42.4 bits (98), Expect = 0.003
Identities = 53/221 (23%), Positives = 78/221 (35%), Gaps = 29/221 (13%)
Query: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
R +P SG P D+AP+ + + V K E + I+ T
Sbjct: 11089 RKLRPGSG-----GEKPPDEAPFTYQLKAVPLKFVKEIKDIIL------------TESEF 11131
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG---SLHLDRALQEHAGRYS 837
G C+V + W+KDG + +H ADG LH+ AG Y+
Sbjct: 11132 VGSSAIFECLVSPSTAITT--WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYT 11189
Query: 838 CVATNTAGSQHRDVELVV-QVPPRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTKE 895
CV + +LVV ++P R T +T +G P L C + + W K+
Sbjct: 11190 CVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKD 11247
Query: 896 TNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATN 933
+ + G L I DAG Y T N
Sbjct: 11248 GKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN 11288
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/77 (35%), Positives = 35/77 (45%), Gaps = 10/77 (12%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDS-------RPVPPITNRYGLLPSGSLRLAQVQ 1018
+T KAG+ + L+ +G P P V WTKD P I R S L + +
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTR---ADSSKFSLTKAK 18267
Query: 1019 VGDSGHYECTASNPAGS 1035
D G Y TA+N AGS
Sbjct: 18268 RSDGGKYVVTATNTAGS 18284
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/160 (25%), Positives = 65/160 (40%), Gaps = 20/160 (12%)
Query: 890 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
IT +E R Y+V K+ +L++ + A N VG S V
Sbjct: 18834 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA 18893
Query: 950 ------PRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR 1003
P+I M P Q+T KAG+++ ++ G P P W K V +T+
Sbjct: 18894 KEQLLPPKILM--------PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEV--VTSS 18943
Query: 1004 YGLL----PSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039
+ + S L + V DSG+Y TA N +G+ + +
Sbjct: 18944 HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQK 18983
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 13/132 (9%)
Query: 463 TDGGRY--QCVASNANG--VTRASVWLLVREA---PQVSIHTSSQHF---SQGVEVKVSC 512
T+G Y Q +A N+ G R S ++V+E P++ + Q G +KV
Sbjct: 21028 TEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEI 21087
Query: 513 SASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTD 569
G P P ++W + Q L++ R++ + T L I D+G Y A N VG
Sbjct: 21088 PVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEV 21147
Query: 570 QETVTLYYTDPP 581
+ +T+ D P
Sbjct: 21148 GDVITIQVHDIP 21159
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 20/159 (12%)
Query: 436 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-SVWLLVR-----E 489
+W+++ TG L EIS + + + A N G+ A SV V+ E
Sbjct: 23965 EWQIVTPQTG----LRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLE 24020
Query: 490 APQVSIHTSSQHFSQGVEVKVSCSA------SGYPTPHISWSRESQALQEDSRIHVDAQG 543
AP++ + + + +G+ V+ SA G PTP I+WSRE + +I
Sbjct: 24021 APELDLDSELR---KGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNY 24077
Query: 544 T-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
T L I DAG Y + N G+ VT+ D P
Sbjct: 24078 TQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTP 24116
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 7/117 (5%)
Query: 489 EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG-- 543
E P++ + H G +KV SG P P ++ SR+ L+ R + +
Sbjct: 26472 EPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN 26531
Query: 544 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
T+ ++ DAG Y A N GT + + + D P VV+ + EE+V
Sbjct: 26532 LTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPG-PPTGPVVISDITEESV 26587
Score = 42.0 bits (97), Expect = 0.004
Identities = 81/394 (20%), Positives = 136/394 (34%), Gaps = 71/394 (18%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 563
G +++ + G PTP WS+ L + IH D+ TL ++ DAG Y+
Sbjct: 28372 GASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVE 28431
Query: 564 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY----RGGL 619
N G+ T T+ D P PP I + RG
Sbjct: 28432 NNSGSKSITFTVKVLDTPG--------------------------PPGPITFKDVTRGSA 28465
Query: 620 EMIL-APEGSSSGKLRIPAAQERDAG-----------TYTCRAVNELGD-------ASAE 660
++ AP ++ ++R+A T VN+L + SA
Sbjct: 28466 TLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAV 28525
Query: 661 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 720
+ VG ++ E P T + L T + + W + D G
Sbjct: 28526 NEYGVGEPYEMPE-PIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM 28584
Query: 721 RSRQPDSGV---------LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
R + D V E + + + + +A+N G + PQI
Sbjct: 28585 RQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE 28644
Query: 772 SSAPTVRVLE-------GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSI---RADG 821
+A + G P ++ + ++GRP P+ W + L R SI +
Sbjct: 28645 PTADLTGITNQLITCKAGSPFTID-VPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT 28703
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV 855
+L + +++ +GRY NTAG + V +VV
Sbjct: 28704 TLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV 28737
Score = 41.6 bits (96), Expect = 0.005
Identities = 46/221 (20%), Positives = 82/221 (37%), Gaps = 35/221 (15%)
Query: 835 RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHH--------ITNEGVPASLPCVASGVP 886
R+ A N G D + ++ ++ P + + G P + GVP
Sbjct: 17479 RFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVP 17538
Query: 887 APTITWTKETNALTSRGPHYNVSKE---GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMR 943
PT WT + + + + HY V + L I +D G Y T +N G + +
Sbjct: 17539 VPTAKWTTDGSEIKT-DEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVH 17597
Query: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP------PLVTWTKDSRPV 997
L+V P P+ + E +T+ + PP P++ + + +
Sbjct: 17598 LTVLDVP-------GPPTGPINILDVTPEHMTISWQ----PPKDDGGSPVINYIVEKQDT 17646
Query: 998 PPITNRYGLLPSGS----LRLAQVQVGDSGHYECTASNPAG 1034
T +G++ SGS L++ +Q G + A N G
Sbjct: 17647 RKDT--WGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIG 17685
Score = 41.6 bits (96), Expect = 0.005
Identities = 93/469 (19%), Positives = 155/469 (33%), Gaps = 62/469 (13%)
Query: 602 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDAS--- 658
CE G + G M P G + + + E+ + A+N+ G
Sbjct: 22867 CEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHAD 22926
Query: 659 ------AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
E +L EL + + + G S L GRP P V W + DG+
Sbjct: 22927 VPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDA 22986
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 772
+ S + L ++V D Y N G A + V P +
Sbjct: 22987 AIIDVTSSFTS------LVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNL 23040
Query: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRAL 829
+ P ++ G + ++++ + R S ++ + S +D+ L
Sbjct: 23041 KVTEITKDSVSITWEPPLLDGGSKI--KNYIVEKREATRKSYAAVVTNCHKNSWKIDQ-L 23097
Query: 830 QEHAGRYSCV-ATNTAG----SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASG 884
QE Y V A N G +Q D V +VP +T V
Sbjct: 23098 QEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSV---------- 23147
Query: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
+++WTK + S+ Y V + + TN R+
Sbjct: 23148 ----SLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRV 23203
Query: 945 -SVNTKPRIHMNGSRNANVPL----------------QVTAKAGEEVTLDCEAKGSPPPL 987
+VN K R + R+ VP+ + + G+++ ++ G P P
Sbjct: 23204 VAVNEKGR---SDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPT 23260
Query: 988 VTWTKDSRPVPPIT--NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
+TWTKD P+ T N L +L + + D G Y T +N G
Sbjct: 23261 ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG 23309
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/114 (25%), Positives = 40/114 (35%), Gaps = 3/114 (2%)
Query: 837 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
SC T T + R + + T H+ G L G P PT W+K
Sbjct: 28339 SCEVTGTIKAVDRLTAPELDIDANFKQT---HVVRAGASIRLFIAYQGRPTPTAVWSKPD 28395
Query: 897 NALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
+ L+ R + TL + + DAG Y T N G S + V P
Sbjct: 28396 SNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTP 28449
Score = 41.2 bits (95), Expect = 0.006
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 13/157 (8%)
Query: 457 ISGIIPTDGGRYQCVASNANGV----TRASVWLLVR---EAPQVSIHTSSQH---FSQGV 506
+SG+ ++ +A NA G + S + R EAP++ + + G
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 21477
Query: 507 EVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQAT 563
++ SG P P + WS++ + L+ +++ + D L+ + D+G Y+ AT
Sbjct: 21478 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTAT 21537
Query: 564 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
N G + + D P V E+ VL
Sbjct: 21538 NPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVL 21574
Score = 41.2 bits (95), Expect = 0.006
Identities = 28/97 (28%), Positives = 40/97 (41%), Gaps = 4/97 (4%)
Query: 857 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKE---GT 913
+ P + P + + G + SG P PTITWTK+ L + NV+ T
Sbjct: 23228 IEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL-KQTTRINVTDSLDLTT 23286
Query: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
L I + D G Y T N VG + + + KP
Sbjct: 23287 LSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 40.8 bits (94), Expect = 0.008
Identities = 43/175 (24%), Positives = 68/175 (38%), Gaps = 26/175 (14%)
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ--- 847
++ R LP WLK + S + + ++ A + +A N AG+
Sbjct: 21392 IVEKRDLPNGRWLK--------ANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPP 21443
Query: 848 ---------HRDVELV-VQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETN 897
DVE ++V + T I G L SG P PT+ W+K+
Sbjct: 21444 SEPSDAITCRDDVEAPKIKVDVKFKDTV---ILKAGEAFRLEADVSGRPPPTMEWSKDGK 21500
Query: 898 ALTSRGP-HYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFSSQEMRLSVNTKP 950
L ++ T L+ + S + D+GAY TATN GF+ + V +P
Sbjct: 21501 ELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555
Score = 40.8 bits (94), Expect = 0.008
Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 489 EAPQVSIHTSSQ---HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT- 544
EAP + + + + G +++ G PTP + W + +++ + I V + T
Sbjct: 22938 EAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS 22997
Query: 545 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
L++ V D+G Y+ N GT VT+ D PS
Sbjct: 22998 LVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPS 23035
Score = 40.8 bits (94), Expect = 0.008
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 10/77 (12%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKD-----SRPVPPITNRYGLLPSGSLRLAQVQVG 1020
VT +AG + L G PPP++TW+K SR + T Y L L + +V
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL-----LIVDKVNRY 29510
Query: 1021 DSGHYECTASNPAGSAS 1037
D+G Y A N +G S
Sbjct: 29511 DAGKYTIEAENQSGKKS 29527
Score = 40.4 bits (93), Expect = 0.010
Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 4/85 (4%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL---LPSGSLRLAQVQVGDS 1022
+T + G+ + + KG P P +TWTK+ + V R L LP L++ + D
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLPRVELQIKEAVRADH 17976
Query: 1023 GHYECTASNPAGSASHRYVLGVQGR 1047
G Y +A N +G A ++ V R
Sbjct: 17977 GKYIISAKNSSGHAQGSAIVNVLDR 18001
Score = 40.4 bits (93), Expect = 0.010
Identities = 25/72 (34%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 967 TAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT--NRYGLLPSGSLRLAQVQVGDSGH 1024
T AGE++ +D G P P VTW KD+ P+ T N + L + D GH
Sbjct: 22158 TVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGH 22217
Query: 1025 YECTASNPAGSA 1036
Y +N AG A
Sbjct: 22218 YVVKLTNSAGEA 22229
Score = 40.4 bits (93), Expect = 0.010
Identities = 33/138 (23%), Positives = 56/138 (40%), Gaps = 23/138 (16%)
Query: 373 EEGTYECTAVSRAGTGR------AKAQIVVTDPPPQLVPAPNVTVSP----------GET 416
E+ YE ++R G + I D + APN ++ P GET
Sbjct: 24669 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDE----IDAPNASLDPKYKDVIVVHAGET 24724
Query: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRV---AQLADLSLEISGIIPTDGGRYQCVAS 473
VL + G+ ++ W +D + L + R+ + + +L + I TDGG+Y S
Sbjct: 24725 FVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLS 24784
Query: 474 NANGVTRASVWLLVREAP 491
N G + + V + P
Sbjct: 24785 NVGGTKSIPITVKVLDRP 24802
Score = 40.0 bits (92), Expect = 0.014
Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 13/165 (7%)
Query: 616 RGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA-----SAEIQLA-VGHAP 669
RG + + E + K+ + +E Y +A+N G + + EIQ AP
Sbjct: 13629 RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAP 13688
Query: 670 QL---TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 726
++ +L +TV+ G L TG+P P +TW + D + R + P
Sbjct: 13689 EIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD----MILKQDKRITIENVPK 13744
Query: 727 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
+ D Y+ EA NV G+ A + V P A
Sbjct: 13745 KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 13789
Score = 40.0 bits (92), Expect = 0.014
Identities = 29/97 (29%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 776 TVRVLEGQPVSLPCIVLAGRPLPERHWLK---------DGRPLPPGSRHSIRADGSLHLD 826
T++V G+PV +P V G P+P+ W K D + A L +
Sbjct: 15407 TIKVKAGEPVHIPADV-TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIP 15465
Query: 827 RALQEHAGRYSCVATNTAGSQHRDVELVV---QVPPR 860
+A++E G Y+ A+N GS R+V + V PPR
Sbjct: 15466 KAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPR 15502
Score = 40.0 bits (92), Expect = 0.014
Identities = 101/488 (20%), Positives = 173/488 (35%), Gaps = 75/488 (15%)
Query: 285 VKGKDHEGNPLLRVSGVSYSGVAPGA----PLVSMAPRIHGYLHQPLLVSCSVHSA-LPF 339
++G D++ RV ++ +GV P + P + P P + + SA L +
Sbjct: 16386 IEGSDYQ----FRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEW 16441
Query: 340 RLQLRRGEARL-GEERHFQESGNSSWEI-----LRASKA-----EEGTY---ECTAVSRA 385
L+ G +++ G ++E G WE +R +K +EG + AV+ A
Sbjct: 16442 SPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIA 16501
Query: 386 GTGRA---------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD 436
G G K ++V D + V G + V G+ P +TW +
Sbjct: 16502 GIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMN 16561
Query: 437 WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 496
R LP S+ I + G Y +A N G + ++ + V + P
Sbjct: 16562 ERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGT 16621
Query: 497 TSSQHFSQGVEVKVSCSA----SGYP-TPHISWSRESQALQEDSRIHVDAQGTLIIQGVA 551
H K++ + G P T ++ RES + + +QG+
Sbjct: 16622 PFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLI 16681
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVP--- 608
A + A N +G + + + + V E + V E +
Sbjct: 16682 QGKAYFFRIAAENSIGMGP------FVETSEALVIREPITVPERPEDLEVKEVTKNTVTL 16735
Query: 609 ---PPRVIWYRGGLEMI----------------LAPEGSSSGKLRIPAAQERDAGTYTCR 649
PP+ Y GG E+I + + S K + +E D Y
Sbjct: 16736 TWNPPK---YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVS 16792
Query: 650 AVNELGD-----ASAEIQLAVGHAPQLTELP-RD-VTVELGRSALLACRATGRPPPTVTW 702
AVN +G + I AP L RD +T+ +G + L R +G+P P V+W
Sbjct: 16793 AVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSW 16852
Query: 703 RRGDGQPL 710
+ + L
Sbjct: 16853 FKDEADVL 16860
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/86 (26%), Positives = 35/86 (40%)
Query: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQ 1018
+A+V ++ AG + + G PPP VTW + R +P S S+ + Q
Sbjct: 16527 DASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQ 16586
Query: 1019 VGDSGHYECTASNPAGSASHRYVLGV 1044
G Y A N AG ++ V
Sbjct: 16587 RSHQGVYSLLAKNEAGERKKTIIVDV 16612
Score = 40.0 bits (92), Expect = 0.014
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 767 PPQIASSAPTVR---VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS- 822
PP++ A R + G + L I+ G P P+ W K+ R P +R + GS
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAII-KGVPFPKVTWKKEDRDAPTKARIDVTPVGSK 17273
Query: 823 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
L + A E G YS N AGS+ V+++V P
Sbjct: 17274 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 39.7 bits (91), Expect = 0.018
Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 14/105 (13%)
Query: 852 ELVVQVPPRIHPTA---THHI-TNEGVPASLPCVASGVPAPTITWTKE------TNALTS 901
E VV P PT TH I EG S+P VP PT++W K+ ++ LT
Sbjct: 14376 ENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTM 14435
Query: 902 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
+ H + E + + DAG Y T N +G ++ + + V
Sbjct: 14436 KNDHISAHLE----VPKSVRADAGIYTITLENKLGSATASINVKV 14476
Score = 39.7 bits (91), Expect = 0.018
Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 8/86 (9%)
Query: 873 GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT--------LLIAQPSAQDA 924
G P +P +G+P P I W+K + ++KE L I + +D
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 15472
Query: 925 GAYVCTATNTVGFSSQEMRLSVNTKP 950
G Y TA+N +G + + + V +P
Sbjct: 15473 GTYTVTASNRLGSVFRNVHVEVYDRP 15498
Score = 39.7 bits (91), Expect = 0.018
Identities = 40/164 (24%), Positives = 62/164 (37%), Gaps = 19/164 (11%)
Query: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796
P+ P C+ + V V+ + +LI + V G V P I+ G P
Sbjct: 17493 PDTTIPIECQEKLVPPSVELDVKLI-------------EGLVVKAGTTVRFPAII-RGVP 17538
Query: 797 LPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL 853
+P W DG + +++ D L + L+ G Y +N AGS+ V L
Sbjct: 17539 VPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHL 17598
Query: 854 -VVQVP-PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE 895
V+ VP P P +T E + S +P I + E
Sbjct: 17599 TVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVE 17642
Score = 39.7 bits (91), Expect = 0.018
Identities = 144/757 (19%), Positives = 252/757 (33%), Gaps = 113/757 (14%)
Query: 362 SSWEILRASKAEEGTYECTAVSRAGTGRA-KAQIVVT---------DPPPQLVPAPNVTV 411
+++ + R + E T+ +A ++ G G K++ +V PPP +V + +V
Sbjct: 20133 TTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSV 20192
Query: 412 S--------PGETAVLSCRVLGEAPYNLTW---------VRDWRVLPASTGRVAQLADLS 454
S G + + + + +L W +RD++V + G + ++
Sbjct: 20193 SLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMA 20252
Query: 455 LEISGIIPTDGGRYQCVASN---------ANGVTRASVWLLVREAPQVSIHTSSQHFSQG 505
+ ++G+ VA + +TR SV L+ E H + + +
Sbjct: 20253 INLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEK 20312
Query: 506 VEV--KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
++ K A+ P +++ + A+ T E C+
Sbjct: 20313 RDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDE 20372
Query: 564 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-- 621
E T T+ D ++ A + +VL A+ G P P+ W + G ++
Sbjct: 20373 YEAPTIVLDPTI--KDGLTIKAGDTIVLNAIS--------ILGKPLPKSSWSKAGKDIRP 20422
Query: 622 ---ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDV 678
+S L I A +DAG YT A N G +++ V P
Sbjct: 20423 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPG----- 20477
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR-------SRQPDSGVLF 731
VE+ + T PP G P+ + R + S S
Sbjct: 20478 PVEISNVSAEKATLTWTPP-----LEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 20532
Query: 732 FESVAPEDQAPYVCEARNVFGK---VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLP 788
+ ++ + A N +GK VQ+E +V PP V +
Sbjct: 20533 ATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTAT--- 20589
Query: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V RP+ DG G R SL RA++ C T
Sbjct: 20590 --VSWKRPVD------DGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGST 20641
Query: 849 RDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV 908
+ + + I P + + A+ P P T T TK++ +L PHY+
Sbjct: 20642 YEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDT-TKKSASLAWGKPHYDG 20700
Query: 909 SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSR---------- 958
E T + + A++ T T +Q + + TK + + S
Sbjct: 20701 GLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPA 20760
Query: 959 ------------------NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1000
+A + + +AG + + KG P P VTWTKD+ +
Sbjct: 20761 VIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNR 20820
Query: 1001 TNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
N L + + D+G + T NPAG S
Sbjct: 20821 ANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKS 20857
Score = 39.7 bits (91), Expect = 0.018
Identities = 90/398 (22%), Positives = 143/398 (35%), Gaps = 64/398 (16%)
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF 731
+E+ + + V+ G S + GRP P V W + D LR A + + L
Sbjct: 26190 SEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTD---LRTRAYVDTTDSRTS---LT 26243
Query: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV 791
E+ D Y +NV A L+V P P + Q V+ V
Sbjct: 26244 IENANRNDSGKYTLTIQNVLSA--ASLTLVVKVLDTP-----GPPTNITV-QDVTKESAV 26295
Query: 792 LAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ---- 847
L+ +PE DG P + H + + S ++ + R S TN
Sbjct: 26296 LSW-DVPEN----DGGA-PVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYF 26349
Query: 848 --HRDVELVVQVPPRIHPTATHHITNEGV--------PASLPCVASGVPAPTITWTKETN 897
+ E V +P T EGV P L + + ++TW K +
Sbjct: 26350 RVSGENEFGVGIPAE---------TKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEH 26400
Query: 898 ALTSRGPHY---------------NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS-QE 941
SR HY V+K +++ + A N G S +E
Sbjct: 26401 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRE 26460
Query: 942 MRLSVNTKPRIHMNGSRNANVPLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1000
+ L V K ++ N P V +AG + +D G P P VT ++D P+
Sbjct: 26461 LLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPL-KA 26519
Query: 1001 TNRYG---LLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
T R+ + ++ L + D+G YE TA+N +G+
Sbjct: 26520 TMRFNTEITAENLTINLKESVTADAGRYEITAANSSGT 26557
Score = 39.7 bits (91), Expect = 0.018
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQV---GDS 1022
VT +AG ++ LD G P P + WTK + + + + L +G A ++ DS
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL-DLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 1023 GHYECTASNPAGS 1035
G Y T N +G+
Sbjct: 29116 GKYTLTVKNASGT 29128
Score = 39.3 bits (90), Expect = 0.023
Identities = 100/471 (21%), Positives = 155/471 (32%), Gaps = 85/471 (18%)
Query: 641 RDAGTYTCR--AVNELGDA----SAEIQLAVGHAPQLTELPRDVTVE------LGRSALL 688
R+ Y R AVN G+ + + +A P EL DV+V+ G++ +
Sbjct: 15067 REGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVEL--DVSVKGGIQIMAGKTLRI 15124
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
TGRP PT W + +G+ L R L + +D YV A
Sbjct: 15125 PAVVTGRPVPTKVWTKEEGE-----LDKDRVVIDNVGTKSELIIKDALRKDHGRYVITAT 15179
Query: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRP 808
N G A AR+ V P VL+ +P V+ R + +W P
Sbjct: 15180 NSCGSKFAAARVEVFDVPGP----------VLDLKP------VVTNRKMCLLNW---SDP 15220
Query: 809 LPPGSRHSI-----RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ------V 857
G R D +H R E R C T Q ++ +
Sbjct: 15221 EDDGGSEITGFIIERKDAKMHTWRQPIE-TERSKCDITGLLEGQEYKFRVIAKNKFGCGP 15279
Query: 858 PPRIHP-TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 916
P I P A + P L T+ W + + S Y + K
Sbjct: 15280 PVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRH--- 15336
Query: 917 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVT--------- 967
+P + +C T+ + + E ++ ++ G ++PL V
Sbjct: 15337 DKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPT 15396
Query: 968 -------------AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL------- 1007
KAGE V + + G P P + W+K+ + T+ +
Sbjct: 15397 IKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRS 15456
Query: 1008 -PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPV 1057
L + + D G Y TASN GS + V R S P++L V
Sbjct: 15457 EAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPS-PPRNLAV 15506
Score = 39.3 bits (90), Expect = 0.023
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 5/103 (4%)
Query: 853 LVVQVPPRIHPTATHH---ITNEGVPASLPCVASGVPAPTITWTKETNALT-SRGPHYNV 908
L VPPRI + G L G P PT++W K+ L + G +
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM 19346
Query: 909 SKE-GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
+ TL + + +D+G Y TA N+ G S ++L V KP
Sbjct: 19347 QRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 39.3 bits (90), Expect = 0.023
Identities = 24/84 (28%), Positives = 38/84 (45%), Gaps = 3/84 (3%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 561
G V + + G P P +SW ++ L+ I + Q TL + V +D+G+Y+
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTIT 19369
Query: 562 ATNEVGTDQETVTLYYTDPPSVSA 585
A N G+ T+ L D P A
Sbjct: 19370 AENSSGSKSATIKLKVLDKPGPPA 19393
Score = 39.3 bits (90), Expect = 0.023
Identities = 52/238 (21%), Positives = 92/238 (38%), Gaps = 25/238 (10%)
Query: 368 RASKAEEGT---YECTAVSRAGTGRAKAQ---IVVTDP-PPQLVPAPNVTVSPGETAVLS 420
+A EEG + A + G G+A V DP P P P + V E +
Sbjct: 23483 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEP-IMVKRNEITLQW 23541
Query: 421 CRVLGEAPYNLT-WVRDWRVLPASTGRVAQLADL---SLEISGIIPTDGGRYQCVASNAN 476
+ + + +T ++ + R LP A ++ +SG+ ++ +A NA
Sbjct: 23542 TKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA 23601
Query: 477 GVTRA---SVWLLVR----EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSR 526
G S + E P++S+ + + G ++ G P P I W R
Sbjct: 23602 GAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 23661
Query: 527 ESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
+ ++E +R + D + LI++ D G Y +A+N G+ V + D P
Sbjct: 23662 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP 23719
Score = 39.3 bits (90), Expect = 0.023
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 496 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAP 552
+T + G VK+ SG P P I W ++ + LQ ++ + V+ +++I+
Sbjct: 26878 YTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADR 26937
Query: 553 EDAGNYSCQATNEVGTDQETVTLYYTDPP 581
++G Y + N +G+ T+ + D P
Sbjct: 26938 LNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 39.3 bits (90), Expect = 0.023
Identities = 36/129 (27%), Positives = 52/129 (40%), Gaps = 16/129 (12%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVT-DPPPQ---LVPA-----PNVTVSPGETAVLSCRV 423
++ Y A ++ G KA++ VT PPP L P N G++ RV
Sbjct: 31759 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 31818
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLAD-----LSLEISGIIPTDGGRYQCVASNANGV 478
G P L W +D + P S G ++ +L I +P D G Y+ A+N G
Sbjct: 31819 SGIPPPTLKWEKDGQ--PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGS 31876
Query: 479 TRASVWLLV 487
T L V
Sbjct: 31877 TSCQAHLQV 31885
Score = 39.3 bits (90), Expect = 0.023
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 4/96 (4%)
Query: 857 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT----KETNALTSRGPHYNVSKEG 912
+PP+I + +EG ++ C +G P P +TW+ K + R N
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT 948
TL+I QD G Y + N G S + + + +
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRS 33422
Score = 38.9 bits (89), Expect = 0.030
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 409 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL---SLEISGIIPTDG 465
+TV G+T + RV G ++TW ++ +VL RV + DL L+I + D
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQDLPRVELQIKEAVRADH 17976
Query: 466 GRYQCVASNANGVTRASVWLLVREAP 491
G+Y A N++G + S + V + P
Sbjct: 17977 GKYIISAKNSSGHAQGSAIVNVLDRP 18002
Score = 38.9 bits (89), Expect = 0.030
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 8/94 (8%)
Query: 956 GSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---- 1011
G +A++ + +AG + L KG PPP +TW S+P + +R GL +
Sbjct: 19693 GELDADLRKTLILRAGVTMRLYVPVKGRPPPKITW---SKPNVNLRDRIGLDIKSTDFDT 19749
Query: 1012 -LRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
LR V D+G Y T N G + V+ V
Sbjct: 19750 FLRCENVNKYDAGKYILTLENSCGKKEYTIVVKV 19783
Score = 38.9 bits (89), Expect = 0.030
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 884 GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMR 943
G PAP +TWTK+ L +R N L+I + + D G +V T N G S +
Sbjct: 20802 GRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVN 20861
Query: 944 LSVNTKP 950
+ V P
Sbjct: 20862 VRVLDTP 20868
Score = 38.9 bits (89), Expect = 0.030
Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 13/109 (11%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRI---------PAAQE 640
V++ GE L + SG PPP + W + G E+ EG++ +++I +
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKEL----EGTAKLEIKIADFSTNLVNKDSTR 21526
Query: 641 RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLA 689
RD+G YT A N G A + V P E P VT +L+
Sbjct: 21527 RDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLS 21575
Score = 38.5 bits (88), Expect = 0.039
Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 22/218 (10%)
Query: 659 AEIQLAVGHAPQLTELP--RDVTVELGRSALLACRATGRPPPTVTWR---RGDGQPL--- 710
AE + VGH + TE+ D T L GR + W+ + G P+
Sbjct: 14260 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 14319
Query: 711 ---GLRLGAGRGSRSRQPDSGVLFF---ESVAPEDQAPYVCEARNVFGKVQ-AEARLIVT 763
+G + R L F E V P+ + A N G + +E V
Sbjct: 14320 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVV 14379
Query: 764 GHAP---PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD 820
P P I + V+EG+ +S+P + P+P W KDG+ + R +++ D
Sbjct: 14380 AKDPDCKPTIDLETHDIIVIEGEKLSIP-VPFRAVPVPTVSWHKDGKEVKASDRLTMKND 14438
Query: 821 G-SLHLD--RALQEHAGRYSCVATNTAGSQHRDVELVV 855
S HL+ ++++ AG Y+ N GS + + V
Sbjct: 14439 HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476
Score = 38.5 bits (88), Expect = 0.039
Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 7/100 (7%)
Query: 488 REAPQVSIHTSSQHFSQ---GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 544
+E P V + S + Q G +++ +G P P W++E L +D R+ +D GT
Sbjct: 15099 QEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKD-RVVIDNVGT 15157
Query: 545 ---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
LII+ +D G Y ATN G+ + D P
Sbjct: 15158 KSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197
Score = 38.5 bits (88), Expect = 0.039
Identities = 34/126 (26%), Positives = 51/126 (40%), Gaps = 11/126 (8%)
Query: 835 RYSCVATNTAG-SQHRDVELVVQVPPRIHPT--------ATHHITNEGVPASLPCVASGV 885
++ +A N AG S V V V R+ P A G L + GV
Sbjct: 17186 KFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGV 17245
Query: 886 PAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
P P +TW KE ++ +V+ G+ L I + +D G Y T N G + +++
Sbjct: 17246 PFPKVTWKKEDRDAPTKA-RIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKV 17304
Query: 945 SVNTKP 950
V KP
Sbjct: 17305 LVLDKP 17310
Score = 38.5 bits (88), Expect = 0.039
Identities = 21/97 (21%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 733
+P +T++ G+ + G+P PT W++G+ + + + + + S +L +
Sbjct: 18904 MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEV----VTSSHLAVHKADSSSILIIK 18959
Query: 734 SVAPEDQAPYVCEARNVFGKVQAEARLIV-TGHAPPQ 769
V +D Y A N G + +++V PPQ
Sbjct: 18960 DVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQ 18996
Score = 38.5 bits (88), Expect = 0.039
Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 6/116 (5%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR---HSIRADGSL 823
PP T VL G+ + + + GRP P W KD PL +R S + L
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVD-VPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLL 22205
Query: 824 HLDRALQEHAGRYSCVATNTAGSQHRDVELVV--QVPPRIHPTATHHITNEGVPAS 877
+ A +E G Y TN+AG + ++V + P P +T + + S
Sbjct: 22206 TIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLS 22261
Score = 38.5 bits (88), Expect = 0.039
Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 4/95 (4%)
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLH 824
P + + + V GQ + + + ++GRP P W KDG PL +R ++ +L
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIE-VPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLS 23288
Query: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
+ ++ G+Y N G + +E+V P
Sbjct: 23289 IKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 38.5 bits (88), Expect = 0.039
Identities = 46/202 (22%), Positives = 76/202 (37%), Gaps = 21/202 (10%)
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRA---DGSLHLDRALQEHAGRYSCVATNTAGSQ 847
++ R LP+ W+K ++ ++ D + AG S + +T
Sbjct: 23556 IVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPIT 23615
Query: 848 HRD-VELV-VQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNAL--TSRG 903
+D VEL + + P+ T + N G L G P PTI W + + ++R
Sbjct: 23616 AKDEVELPRISMDPKFRDTI---VVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARC 23672
Query: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963
N + L++ D G Y+ A+N G S + + V +P P
Sbjct: 23673 EIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP-------GPPEGP 23725
Query: 964 LQVTAKAGEEVTLDCEAKGSPP 985
+QVT E+ C SPP
Sbjct: 23726 VQVTGVTSEK----CSLTWSPP 23743
Score = 38.5 bits (88), Expect = 0.039
Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 19/165 (11%)
Query: 346 GEARLGEERHFQESGNSSWEILRASKA-----------EEGTYECTAVSRAGTGRAKAQI 394
G LG Q G W I+ SK +E + A + G +
Sbjct: 24241 GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLG 24300
Query: 395 V------VTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-RV 447
V +T P +P ++ GE + V+G N++WV+D L +T V
Sbjct: 24301 VPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV 24360
Query: 448 AQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
+ A + L I D G+Y A+N+ G ++ ++V E P
Sbjct: 24361 EETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 38.5 bits (88), Expect = 0.039
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 863 PTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT---LLIAQ 918
P T+ I E + +P + G P P I+W K+ L + NV + T L I +
Sbjct: 24317 PFNTYSIQAGEDLKIEIPVI--GRPRPNISWVKDGEPL-KQTTRVNVEETATSTVLHIKE 24373
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
+ D G Y TATN+ G +++ + + V KP
Sbjct: 24374 GNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 38.1 bits (87), Expect = 0.051
Identities = 38/169 (22%), Positives = 58/169 (34%), Gaps = 26/169 (15%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 561
G V+ G P P W+ + ++ D V+ L I+ D G Y
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQIT 17584
Query: 562 ATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM 621
+N G+ V L D P +L E + + PP+ GG +
Sbjct: 17585 VSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQ-----PPKD---DGGSPV 17636
Query: 622 I---------------LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
I + GSS KL+IP Q+ + RA N++G
Sbjct: 17637 INYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIG 17685
Score = 38.1 bits (87), Expect = 0.051
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSR---IHVDAQGTLIIQGVAPEDAGNYSCQ 561
G +K++ +G P P ISW+++ ++E +R I D L ++ D G Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863
Query: 562 ATNEVGTDQETVTLYYTDPPSVSA 585
N GT V D P A
Sbjct: 25864 LKNVAGTRSVAVNCKVLDKPGPPA 25887
Score = 37.7 bits (86), Expect = 0.067
Identities = 18/50 (36%), Positives = 24/50 (48%)
Query: 969 KAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQ 1018
K G+E+ LD GSP P +TW KD + P + P R +VQ
Sbjct: 14692 KRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQ 14741
Score = 37.7 bits (86), Expect = 0.067
Identities = 58/251 (23%), Positives = 101/251 (40%), Gaps = 46/251 (18%)
Query: 367 LRASKAEEGT---YECTAVSRAGTGR-AKAQIVVTDPPPQLVPAP------------NVT 410
L+A+ +EGT + TA+++AG G+ + A PQ P P +V+
Sbjct: 19547 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 19606
Query: 411 VSPGETA------VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTD 464
+S G+ A ++ V + + WVR LP + L E++G++
Sbjct: 19607 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRC--NLPQN------LQKTRFEVTGLMEDT 19658
Query: 465 GGRYQCVASNANGVTRASVW---------LLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 515
+++ A N G + S L+ E + + GV +++
Sbjct: 19659 QYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVK 19718
Query: 516 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 570
G P P I+WS+ + L++ RI +D + T L + V DAG Y N G +
Sbjct: 19719 GRPPPKITWSKPNVNLRD--RIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKE 19776
Query: 571 ETVTLYYTDPP 581
T+ + D P
Sbjct: 19777 YTIVVKVLDTP 19787
Score = 37.7 bits (86), Expect = 0.067
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 4/77 (5%)
Query: 678 VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
V + G + + GRP PTVTW++GD + R + S +L
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGD----QILKQTQRVNFETTATSTILNINECVR 21130
Query: 738 EDQAPYVCEARNVFGKV 754
D PY ARN+ G+V
Sbjct: 21131 SDSGPYPLTARNIVGEV 21147
Score = 37.7 bits (86), Expect = 0.067
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 2/69 (2%)
Query: 969 KAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT--NRYGLLPSGSLRLAQVQVGDSGHYE 1026
KA E++ +D KG P V W KD + + T N SL + + D G YE
Sbjct: 25407 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 1027 CTASNPAGS 1035
SN AGS
Sbjct: 25467 LCVSNSAGS 25475
Score = 37.7 bits (86), Expect = 0.067
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 8/83 (9%)
Query: 873 GVPASLPCVASGVPAPTITWTK-----ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 927
G L SG PAPTI W K +TNAL N + ++LI ++G Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVC---VENTTDLASILIKDADRLNSGCY 26943
Query: 928 VCTATNTVGFSSQEMRLSVNTKP 950
N +G +S +R+ + KP
Sbjct: 26944 ELKLRNAMGSASATIRVQILDKP 26966
Score = 37.4 bits (85), Expect = 0.088
Identities = 37/144 (25%), Positives = 60/144 (41%), Gaps = 13/144 (9%)
Query: 634 RIPAAQERDAGTYTCRAVNELGD------ASAEIQLAVGHAPQ--LTELPRDV-TVELGR 684
R+P E + + +A N +G+ A + I + H P+ L RDV TV +G+
Sbjct: 17865 RVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQ 17924
Query: 685 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 744
+ + R GRP P +TW + +G+ L + R + L + D Y+
Sbjct: 17925 TIRILARVKGRPEPDITWTK-EGKVL---VREKRVDLIQDLPRVELQIKEAVRADHGKYI 17980
Query: 745 CEARNVFGKVQAEARLIVTGHAPP 768
A+N G Q A + V P
Sbjct: 17981 ISAKNSSGHAQGSAIVNVLDRPGP 18004
Score = 37.4 bits (85), Expect = 0.088
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 884 GVPAPTITWTKETNALT-SRGPHYNV---SKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
G P P + WTK+ +A +R P + + + + D G YV TATNT G
Sbjct: 18227 GKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFV 18286
Query: 940 QEMRLSVNTKP 950
++V KP
Sbjct: 18287 AYATVNVLDKP 18297
Score = 37.4 bits (85), Expect = 0.088
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 409 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PASTGRVAQLADL-SLEISGIIPTDGG 466
+TV G L V G+ ++W +D +L PA ++A +L +LE+ + D G
Sbjct: 19305 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSG 19364
Query: 467 RYQCVASNANGVTRASVWLLVREAP 491
Y A N++G A++ L V + P
Sbjct: 19365 DYTITAENSSGSKSATIKLKVLDKP 19389
Score = 37.0 bits (84), Expect = 0.11
Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 5/104 (4%)
Query: 761 IVTGHAPPQIASSAPTVRVLEGQPVSLPCI--VLAGRPLPERHWLKDGRPLPP--GSRHS 816
I+ + PP+I S +L + + C+ + G+P+P W KDG L P G + +
Sbjct: 19286 ILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMA 19345
Query: 817 IRAD-GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
++ + +L L ++ +G Y+ A N++GS+ ++L V P
Sbjct: 19346 MQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 37.0 bits (84), Expect = 0.11
Identities = 49/198 (24%), Positives = 79/198 (39%), Gaps = 34/198 (17%)
Query: 872 EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYV-CT 930
E VPA PC G P T T+++ +L PHY+ + T I + G ++ C
Sbjct: 25677 EPVPARDPCDPPGQPEVT-NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCN 25735
Query: 931 ATNT------VGFSSQEMRL----------------SVNTKPRIHMNGSRNANVPLQV-- 966
TN V +++ R S +T P I + V + V
Sbjct: 25736 YTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKF 25795
Query: 967 ----TAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQ---V 1019
KAGE + ++ + G P P+++W KD + R ++ + + L V+
Sbjct: 25796 RDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEE-RARTEIISTDNHTLLTVKDCIR 25854
Query: 1020 GDSGHYECTASNPAGSAS 1037
D+G Y T N AG+ S
Sbjct: 25855 RDTGQYVLTLKNVAGTRS 25872
Score = 37.0 bits (84), Expect = 0.11
Identities = 26/145 (17%), Positives = 64/145 (44%), Gaps = 13/145 (8%)
Query: 450 LADLSLEISGIIPTDGGRYQCVASNANGV----TRASVWLLVREAPQVSIHTSSQHFSQG 505
+++ ++G+ P D ++ +A NA G +++S ++ R+ I + G
Sbjct: 27908 VSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDG 27967
Query: 506 VEVK------VSCSASGYPTPHISWSRESQALQEDSRIHV-DAQG--TLIIQGVAPEDAG 556
+ +K + G P P ++W ++ +++ + + D G +L ++ + G
Sbjct: 27968 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 28027
Query: 557 NYSCQATNEVGTDQETVTLYYTDPP 581
Y+ +A N G+ + + + D P
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTP 28052
Score = 37.0 bits (84), Expect = 0.11
Identities = 24/86 (27%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--SSGKLR---IPAAQERDA 643
+V + G + VL G P P++IW +G E+ L + S +GK I D+
Sbjct: 29056 LVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 644 GTYTCRAVNELGDASAEIQLAVGHAP 669
G YT N G + + + V +P
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 37.0 bits (84), Expect = 0.11
Identities = 24/90 (26%), Positives = 38/90 (42%), Gaps = 4/90 (4%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVGDS 1022
VT K GE L C+ G P P + W + + + + +Y + G +L + + D
Sbjct: 30542 VTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 1023 GHYECTASNPAGSASHRYVLGVQGRTSWQP 1052
G Y C A+N G L +Q + P
Sbjct: 30601 GVYTCIATNEVGEVETSSKLLLQATPQFHP 30630
Score = 36.6 bits (83), Expect = 0.15
Identities = 106/474 (22%), Positives = 161/474 (33%), Gaps = 86/474 (18%)
Query: 625 PEGSSSGKLRIPAAQERDAGTYTCR--AVNELGDAS-AEIQLAVG-----HAPQL---TE 673
PE K ++ RD TY R AVN G++ A + V P+L
Sbjct: 17166 PESCPETKYKVTGL--RDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDAN 17223
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVLFF 732
+ R+ +++G + L+ G P P VTW++ D P R+ P L
Sbjct: 17224 MAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDV-------TPVGSKLEI 17276
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV----------LEG 782
+ A ED Y N G +++V P +R L+
Sbjct: 17277 RNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDD 17336
Query: 783 QPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA-----DGSLHLDRALQEHA-GRY 836
+ V+ R + W PL S+ +G+ +L R E+ GR
Sbjct: 17337 GGSVITNYVVERRDVASAQW----SPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRG 17392
Query: 837 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 896
V T + ++ + + P P HH+ + SL W K
Sbjct: 17393 PFVETP------KPIKALDPLHPPGPPKDLHHVDVDKTEVSL------------VWNKPD 17434
Query: 897 NALTSRGPHYNVS--KEGT-----------LLIAQPSAQDAGAYV--CTATNTVGFSSQE 941
S Y V +EGT L Q Y A N VG +
Sbjct: 17435 RDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPD 17494
Query: 942 MRLSVNTKPRIHMNGSRNANVPL--QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
+ + + ++ + S +V L + KAG V +G P P WT D +
Sbjct: 17495 TTIPIECQEKL-VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK- 17552
Query: 1000 ITNRYGLLP----SGSLRLAQVQVGDSGHYECTASNPAGS---ASHRYVLGVQG 1046
T+ + + S L + D+G Y+ T SN AGS A H VL V G
Sbjct: 17553 -TDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPG 17605
Score = 36.6 bits (83), Expect = 0.15
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%)
Query: 869 ITNEGVPASLPCVASGVPAPTITWTKETNAL--TSRGPHYNVSKEGTLLIAQPSAQDAGA 926
+ E + +P + G P P +TW K+ L T+R + L I +D G
Sbjct: 22160 LAGEDLKVDVPFI--GRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGH 22217
Query: 927 YVCTATNTVGFSSQEMRLSVNTKP 950
YV TN+ G + + + + V KP
Sbjct: 22218 YVVKLTNSAGEAIETLNVIVLDKP 22241
Score = 36.6 bits (83), Expect = 0.15
Identities = 31/139 (22%), Positives = 61/139 (43%), Gaps = 14/139 (10%)
Query: 457 ISGIIPTDGGRYQCVASNANG----VTRASVWLLVRE---APQVSIHTSSQHF---SQGV 506
+SG++ ++ +A NA G + +S + R+ AP S+ + G
Sbjct: 24664 VSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGE 24723
Query: 507 EVKVSCSASGYPTPHISWSRESQALQEDS-RIHVDA---QGTLIIQGVAPEDAGNYSCQA 562
+ G P P + WS++ + L+E + R+ + + + TL+++ D G Y +
Sbjct: 24724 TFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKL 24783
Query: 563 TNEVGTDQETVTLYYTDPP 581
+N GT +T+ D P
Sbjct: 24784 SNVGGTKSIPITVKVLDRP 24802
Score = 36.6 bits (83), Expect = 0.15
Identities = 20/76 (26%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 508 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEV 566
+++ + G P P + W + L + ++I V + T L+I V D+G Y+ N
Sbjct: 25125 LRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNS 25184
Query: 567 GTDQETVTLYYTDPPS 582
G+ V + D PS
Sbjct: 25185 GSKTAFVNVRVLDSPS 25200
Score = 36.6 bits (83), Expect = 0.15
Identities = 24/98 (24%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 400 PPQL----VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--DL 453
PP++ P+ V V G + + G+ +T RD L A+ ++ +L
Sbjct: 26473 PPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL 26532
Query: 454 SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
++ + + D GRY+ A+N++G T+A + ++V + P
Sbjct: 26533 TINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRP 26570
Score = 36.6 bits (83), Expect = 0.15
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 10/94 (10%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA---QGTLIIQGVAPEDAGNYSCQ 561
G + SG P P ++W E L+E R+ + + TL ++ D+G Y
Sbjct: 28662 GSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLT 28721
Query: 562 ATNEVGTDQETVTLY-------YTDPPSVSAVNA 588
N G +VT+ T P VS+V+A
Sbjct: 28722 LENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSA 28755
Score = 36.6 bits (83), Expect = 0.15
Identities = 33/126 (26%), Positives = 45/126 (35%), Gaps = 14/126 (11%)
Query: 558 YSCQATNEVGTDQ--ETVTLYYTDPPSV-------SAVNAVVLVAVGEEAVLVCEASGVP 608
+ +A NE G + ETVT V + + V G LV +G P
Sbjct: 29707 FRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRP 29766
Query: 609 PPRVIWYRGG-----LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
PP W+ G E + + KL I RD G YT N G S I++
Sbjct: 29767 PPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKV 29826
Query: 664 AVGHAP 669
+ P
Sbjct: 29827 IILDKP 29832
Score = 36.2 bits (82), Expect = 0.20
Identities = 49/223 (21%), Positives = 85/223 (38%), Gaps = 34/223 (15%)
Query: 793 AGRPLPERHWLKDGRPLPPGSRHSIR---ADGSLHLDRALQEHAGRYSCVATNTAGSQHR 849
+G+P P+ W KD + R I+ A +L +A + +G+Y V N+ GS+
Sbjct: 16843 SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKG 16902
Query: 850 --DVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG---- 903
V +V + P + P + +T + + V S P +K TN + +
Sbjct: 16903 FCQVNVVDRPGPPVGPVSFDEVTKDYM------VISWKPPLDDGGSKITNYIIEKKEVGK 16956
Query: 904 ----PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
P + S + T +++ + A N G S + S+ K R + + +
Sbjct: 16957 DVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPD 17016
Query: 960 ANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITN 1002
+ +VT + LVTW K PITN
Sbjct: 17017 QPIVTEVTKDSA---------------LVTWNKPHDGGKPITN 17044
Score = 36.2 bits (82), Expect = 0.20
Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 4/96 (4%)
Query: 400 PPQLVPAPNVT----VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSL 455
PP+L+ N+ + G+T LS + G +TW ++ R P L
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKL 17274
Query: 456 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
EI DGG Y N G SV +LV + P
Sbjct: 17275 EIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 36.2 bits (82), Expect = 0.20
Identities = 28/99 (28%), Positives = 41/99 (41%), Gaps = 10/99 (10%)
Query: 580 PPSVS---AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---- 632
PP + A+ +++ V G L G P P V W + G ++ EG
Sbjct: 19292 PPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT-LLKPAEGIKMAMQRNL 19350
Query: 633 --LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
L + + +D+G YT A N G SA I+L V P
Sbjct: 19351 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 36.2 bits (82), Expect = 0.20
Identities = 30/135 (22%), Positives = 50/135 (37%), Gaps = 11/135 (8%)
Query: 546 IIQGVAPEDAGNYSCQATNEVGTDQETV------TLYYTDPPSVSAVNAVVLVAVGEEAV 599
++ G++ + +A NE G V T PS+ + GE+
Sbjct: 24271 VVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLK 24330
Query: 600 LVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNEL 654
+ G P P + W + G + + E ++S L I + D G YT A N
Sbjct: 24331 IEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSA 24390
Query: 655 GDASAEIQLAVGHAP 669
G A+ + + V P
Sbjct: 24391 GTATENLSVIVLEKP 24405
Score = 35.8 bits (81), Expect = 0.25
Identities = 24/91 (26%), Positives = 38/91 (41%), Gaps = 3/91 (3%)
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS--LRLAQVQVG 1020
P V GE C G P P V W + + + + R+ + G L + +
Sbjct: 1847 PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRK-SKRFRVRYDGIHYLDIVDCKSY 1905
Query: 1021 DSGHYECTASNPAGSASHRYVLGVQGRTSWQ 1051
D+G + TA NP G H+ L +Q R ++
Sbjct: 1906 DTGEVKVTAENPEGVIEHKVKLEIQQREDFR 1936
Score = 35.8 bits (81), Expect = 0.25
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 11/159 (6%)
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR--VAQLADLSLEISGIIPTDGGRYQCV 471
G +A+ C V TW++D + S +A D L I + +D G Y CV
Sbjct: 11133 GSSAIFECLVSPSTAIT-TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 11191
Query: 472 ASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQ 529
N ++ L+V E P + T + + +G + +SC + + W ++ +
Sbjct: 11192 LRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKDGK 11249
Query: 530 -ALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATN 564
+++ RI G L I DAG Y+ N
Sbjct: 11250 IVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN 11288
Score = 35.8 bits (81), Expect = 0.25
Identities = 23/100 (23%), Positives = 41/100 (41%), Gaps = 9/100 (9%)
Query: 492 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---------EDSRIHVDAQ 542
++S+ + G V + +G P P I WS+ ++ ++ +A+
Sbjct: 15400 RLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAK 15459
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
L I ED G Y+ A+N +G+ V + D PS
Sbjct: 15460 TELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPS 15499
Score = 35.8 bits (81), Expect = 0.25
Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 7/103 (6%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQA--LQEDSRIHVDAQ---GTLIIQGVAPEDAGNYS 559
G +++ G P P ++W+++ A L R+ +D + + D G Y
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
ATN G+ T+ D P V + +V V + VC
Sbjct: 18276 VTATNTAGSFVAYATVNVLDKP--GPVRNLKIVDVSSDRCTVC 18316
Score = 35.8 bits (81), Expect = 0.25
Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 5/58 (8%)
Query: 794 GRPLPERHWLKDGRPLP----PGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGS 846
G+P PE W KD P + RAD S L +A + G+Y ATNTAGS
Sbjct: 18227 GKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGS 18284
Score = 35.8 bits (81), Expect = 0.25
Identities = 79/387 (20%), Positives = 130/387 (33%), Gaps = 21/387 (5%)
Query: 673 ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFF 732
+L + + + G + L GRPPP +TW + + + LR G +S D+ L
Sbjct: 19698 DLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPN---VNLRDRIGLDIKSTDFDT-FLRC 19753
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVL 792
E+V D Y+ N GK + + V P + + + P I+
Sbjct: 19754 ENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIID 19813
Query: 793 AGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGR---YSCVATNTAG---- 845
G P+ +++ R S ++ + S R G+ + A N G
Sbjct: 19814 GGSPII--NYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDP 19871
Query: 846 SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ RD Q P + ++ S + I + + LT
Sbjct: 19872 GETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYV--VDFLTEENKW 19929
Query: 906 YNVSKEGTLLIAQPSAQDAGAYV--CTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963
V K +L + + Y +A N G + V + +
Sbjct: 19930 QRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPD 19989
Query: 964 LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVG 1020
L AK L KG P P V+W K P+ T R + S +L + Q
Sbjct: 19990 LCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT-RVSVESSAVNTTLIVYDCQKS 20048
Query: 1021 DSGHYECTASNPAGSASHRYVLGVQGR 1047
D+G Y T N AG+ + V G+
Sbjct: 20049 DAGKYTITLKNVAGTKEGTISIKVVGK 20075
Score = 35.8 bits (81), Expect = 0.25
Identities = 37/172 (21%), Positives = 63/172 (36%), Gaps = 20/172 (11%)
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD 850
++ + LPE W+K + + D + +++H + +A N AG
Sbjct: 22474 IVEKKELPEGRWMK--------ASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEP 22525
Query: 851 VELVVQV-------PPRIHPTATHH---ITNEGVPASLPCVASGVPAPTITWTKETNAL- 899
E + PPRI + + + G + G P PTI W K L
Sbjct: 22526 SESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELS 22585
Query: 900 -TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
T+R + +L + D+G Y+ A N G S + + V +P
Sbjct: 22586 NTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 35.4 bits (80), Expect = 0.33
Identities = 27/128 (21%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 487 VREAPQVSIHTSSQHF---SQGVEVKVSCSASGYPTPHISWSRES--QALQEDSRIHVDA 541
+ E P++ + S + G +++ G P P ++W + +++ VD
Sbjct: 18600 ILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDT 18659
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
L+I +D+G YS N G V + D P V + V +
Sbjct: 18660 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTP-----GPVSDLKVSDVTKTS 18714
Query: 602 CEASGVPP 609
C S PP
Sbjct: 18715 CHVSWAPP 18722
Score = 35.4 bits (80), Expect = 0.33
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI--TNRYGLLPSGSLRLAQVQVGDSG 1023
V AKAG+ + ++ G P P VTW K + + N S L + + DSG
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSG 21134
Query: 1024 HYECTASNPAG 1034
Y TA N G
Sbjct: 21135 PYPLTARNIVG 21145
Score = 35.0 bits (79), Expect = 0.43
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 8/99 (8%)
Query: 776 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRALQEH 832
TVRV GQ + + V GRP P+ W K+G+ L R + D L + A++
Sbjct: 17919 TVRV--GQTIRILARV-KGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRAD 17975
Query: 833 AGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 871
G+Y A N++G H +V V R P +TN
Sbjct: 17976 HGKYIISAKNSSG--HAQGSAIVNVLDRPGPCQNLKVTN 18012
Score = 35.0 bits (79), Expect = 0.43
Identities = 30/120 (25%), Positives = 47/120 (39%), Gaps = 13/120 (10%)
Query: 868 HITNEGVPASLPCVASGVPAPTITWTKETNALTS--RGPHYNVSKEGTLLIAQPSAQDAG 925
++ E L G PAP+++W K + L + R + + TL++ DAG
Sbjct: 19992 YLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAG 20051
Query: 926 AYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP 985
Y T N G + + V KP I P++ E +TL K +PP
Sbjct: 20052 KYTITLKNVAGTKEGTISIKVVGKPGIPTG-------PIKFDEVTAEAMTL----KWAPP 20100
Score = 35.0 bits (79), Expect = 0.43
Identities = 25/79 (31%), Positives = 34/79 (43%), Gaps = 2/79 (2%)
Query: 969 KAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR--YGLLPSGSLRLAQVQVGDSGHYE 1026
K+GE + + +G P P VTW KD + N +L S SL + G Y
Sbjct: 27971 KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030
Query: 1027 CTASNPAGSASHRYVLGVQ 1045
A N +GSA + VQ
Sbjct: 28031 VEAKNASGSAKAEIKVKVQ 28049
Score = 34.7 bits (78), Expect = 0.57
Identities = 30/127 (23%), Positives = 48/127 (37%), Gaps = 12/127 (9%)
Query: 579 DPPSVSA---VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSS 630
DPP +S ++V GE + + G P P + W +G E+ + +
Sbjct: 22539 DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFA 22598
Query: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690
L + A D+G Y +A N G+ S + + V P E P V + C
Sbjct: 22599 TSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGP----VVISGVTAEKC 22654
Query: 691 RATGRPP 697
+PP
Sbjct: 22655 TLAWKPP 22661
Score = 34.7 bits (78), Expect = 0.57
Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 8/134 (5%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKA---QIVVTDP--PPQLVPA-PNVTVSPGETAVL 419
I ++ EE + AV+ G ++ IV D P + PA + +V G+ +
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKI 23249
Query: 420 SCRVLGEAPYNLTWVRDWRVLPASTG-RVAQLADLS-LEISGIIPTDGGRYQCVASNANG 477
+ G +TW +D L +T V DL+ L I DGG+Y +N G
Sbjct: 23250 EVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG 23309
Query: 478 VTRASVWLLVREAP 491
AS+ ++ + P
Sbjct: 23310 QKTASIEIVTLDKP 23323
Score = 34.7 bits (78), Expect = 0.57
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 794 GRPLPERHWLKDGRPLPPGSRHSIRADG---SLHLDRALQEHAGRYSCVATNTAGSQHRD 850
GRP +W KDG+ L +R ++ + SL + A +E G Y +N+AGS
Sbjct: 25420 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 25479
Query: 851 VELVV 855
+ ++V
Sbjct: 25480 ITIIV 25484
Score = 34.7 bits (78), Expect = 0.57
Identities = 68/364 (18%), Positives = 129/364 (35%), Gaps = 60/364 (16%)
Query: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV---------- 411
+S ++ + K E + T V++ G G + + P VP+P ++
Sbjct: 25940 TSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESM 25999
Query: 412 --------SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT 463
S G + + + +L WVR + + DL ++ +G+
Sbjct: 26000 TLCWSRPESDGGSEISGYIIERREKNSLRWVRVNK---------KPVYDLRVKSTGLREG 26050
Query: 464 DGGRYQCVASNANGVTRASVWL-LVREAPQVSIHT--SSQHFSQGVEVKVSCS------- 513
Y+ A NA G++ S L+R V + + S + ++ +
Sbjct: 26051 CEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFD 26110
Query: 514 ----ASGYPTPH-----ISWSRESQALQED----SRIHVDAQGTLIIQGVAPEDAGNYSC 560
+GY + W Q+L+ S + A+ ++ V A + S
Sbjct: 26111 GGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSD 26170
Query: 561 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 620
+ ++ ++E L+ D S + ++V G + G P P V+W + +
Sbjct: 26171 SSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTD 26226
Query: 621 M---ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD 677
+ S L I A D+G YT N L AS + + V P P +
Sbjct: 26227 LRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTP---GPPTN 26283
Query: 678 VTVE 681
+TV+
Sbjct: 26284 ITVQ 26287
Score = 34.3 bits (77), Expect = 0.74
Identities = 30/115 (26%), Positives = 46/115 (40%), Gaps = 10/115 (8%)
Query: 588 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL-----EMILAPEGSSSGKLRIPAAQERD 642
A + V G + L +G P P++ W + + + I + I ++ D
Sbjct: 13698 AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSD 13757
Query: 643 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 697
GTY AVN G A+A +++ V P D+T S LL T PP
Sbjct: 13758 TGTYIIEAVNVCGRATAVVEVNVLDKPG-PPAAFDITDVTNESCLL----TWNPP 13807
Score = 34.3 bits (77), Expect = 0.74
Identities = 31/129 (24%), Positives = 54/129 (41%), Gaps = 17/129 (13%)
Query: 464 DGGRYQ--CVASNANGVTR--ASVWLLVREAPQVSIHTSSQHF---SQGVEVKVSCSASG 516
+GG Y+ A NA GV++ A+V + P + + F +G V + G
Sbjct: 16083 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 16142
Query: 517 YPTPHISWSRESQALQED----------SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV 566
P P ++W + ++ +++ VD TL+I D G Y+ A N +
Sbjct: 16143 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 16202
Query: 567 GTDQETVTL 575
GT + + L
Sbjct: 16203 GTASKEMRL 16211
Score = 34.3 bits (77), Expect = 0.74
Identities = 19/70 (27%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 515 SGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPE--DAGNYSCQATNEVGTDQE 571
SG P P +SW ++ + ED R H+ TL ++ + + D+G Y N G+ +
Sbjct: 16843 SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKG 16902
Query: 572 TVTLYYTDPP 581
+ D P
Sbjct: 16903 FCQVNVVDRP 16912
Score = 34.3 bits (77), Expect = 0.74
Identities = 31/134 (23%), Positives = 52/134 (38%), Gaps = 11/134 (8%)
Query: 547 IQGVAPEDAGNYSCQATNEVGTD---QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVL 600
I G+ + ++ A NE G Q +V + D PP+ + V GE+ +
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 601 VCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
G P P V W++ + + + A ++ L I A D G Y + N G
Sbjct: 22168 DVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
Query: 656 DASAEIQLAVGHAP 669
+A + + V P
Sbjct: 22228 EAIETLNVIVLDKP 22241
Score = 34.3 bits (77), Expect = 0.74
Identities = 39/134 (29%), Positives = 59/134 (44%), Gaps = 23/134 (17%)
Query: 767 PPQIASSAP---TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG-- 821
PP+I+ T+ V G+ + + G+P+P W+K + L +R I++
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIY-GKPIPTIQWIKGDQELSNTARLEIKSTDFA 22598
Query: 822 -SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC 880
SL + A++ +G Y A N AG R V + V+V R P EG P
Sbjct: 22599 TSLSVKDAVRVDSGNYILKAKNVAG--ERSVTVNVKVLDRPGPP-------EG-----PV 22644
Query: 881 VASGVPAP--TITW 892
V SGV A T+ W
Sbjct: 22645 VISGVTAEKCTLAW 22658
Score = 34.3 bits (77), Expect = 0.74
Identities = 23/94 (24%), Positives = 36/94 (38%), Gaps = 5/94 (5%)
Query: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRI 635
P V + V VG++ + SG P P + W + GL + I + L I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 636 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
+ D G Y N +G +A I++ P
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 33.9 bits (76), Expect = 0.97
Identities = 25/109 (22%), Positives = 43/109 (39%), Gaps = 14/109 (12%)
Query: 487 VREAPQVSIHTSSQHF---SQGVEVKVSCSASGYPTPHISWSRESQA----------LQE 533
++E P+V I +Q G ++++ G PTP SW + +A + E
Sbjct: 15804 IQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPE 15863
Query: 534 DSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
D+++ + +II G YS A N+ G + D P
Sbjct: 15864 DAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912
Score = 33.9 bits (76), Expect = 0.97
Identities = 95/469 (20%), Positives = 170/469 (36%), Gaps = 54/469 (11%)
Query: 344 RRGEARLGEERHF--QESGNSSWEILR-ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP 400
++GE + H ++ +SS I++ ++ + G Y TA + +GT K ++VV D P
Sbjct: 18933 KKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Query: 401 PQLVPAPNVTVSPGETAVLSCRV-LGEAPYNLTWVRDWRVLPASTGR------VAQLADL 453
P +++ + LS + L + N+T ++ V R +A +
Sbjct: 18993 GPPQPPFDISDIDADACSLSWHIPLEDGGSNIT---NYIVEKCDVSRGDWVTALASVTKT 19049
Query: 454 SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV-EVKVSC 512
S + +IP ++ A N G++ + Q S+ + V +V C
Sbjct: 19050 SCRVGKLIPGQEYIFRVRAENRFGISEPLT--SPKMVAQFPFGVPSEPKNARVTKVNKDC 19107
Query: 513 SASGYPTPHISWSRES-----QALQEDSRIHVDAQGTLI------IQGVAPEDAGNYSCQ 561
+ P + + +S + V A TL+ G+ ++
Sbjct: 19108 IFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIY 19167
Query: 562 ATNEVGTDQETVTLYYT------DPPSVSAVNAVVLVAV-----------GEEAV-LVCE 603
A N+ G+ + Y DPP V V V G + + E
Sbjct: 19168 ALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVE 19227
Query: 604 ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
A +P + + I E +++G L A + A T ++ + S + +
Sbjct: 19228 ACKLPGDKWVRCNTAPHQIPQEEYTATG-LEEKAQYQFRAIARTAVNISPPSEPSDPVTI 19286
Query: 664 AVGHAPQLTELPRDV----TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG 719
+ P +L + TV+ G + L G+P PTV+W++ DG L G
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK-DGTLLKPAEGI--- 19342
Query: 720 SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
+ Q + L SV +D Y A N G A +L V P
Sbjct: 19343 KMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGP 19391
Score = 33.9 bits (76), Expect = 0.97
Identities = 38/159 (23%), Positives = 59/159 (37%), Gaps = 33/159 (20%)
Query: 550 VAPEDAGNYS--------CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
+A AGN+S A +E+ ++ Y D V++V GE VL
Sbjct: 24678 IARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKD---------VIVVHAGETFVLE 24728
Query: 602 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQER-----------DAGTYTCRA 650
+ G P P V+W + G E+ ++ ++ I + ++ D G Y +
Sbjct: 24729 ADIRGKPIPDVVWSKDGKEL-----EETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKL 24783
Query: 651 VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLA 689
N G S I + V P E P VT LA
Sbjct: 24784 SNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLA 24822
Score = 33.9 bits (76), Expect = 0.97
Identities = 35/116 (30%), Positives = 47/116 (40%), Gaps = 13/116 (11%)
Query: 931 ATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTA----KAGEEVTLDCEAKGSPPP 986
A N VG S + V I G ++PL+ T +AG V L G P P
Sbjct: 26844 ARNAVGSISNPSEV-VGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAP 26902
Query: 987 LVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGD-----SGHYECTASNPAGSAS 1037
+ W KD + + TN + + LA + + D SG YE N GSAS
Sbjct: 26903 TIEWYKDDKELQ--TNAL-VCVENTTDLASILIKDADRLNSGCYELKLRNAMGSAS 26955
Score = 33.9 bits (76), Expect = 0.97
Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 5/86 (5%)
Query: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE-----MILAPEGSSSGKLRIPAAQERDA 643
VV G L SG P P + WY+ E ++ + + I A ++
Sbjct: 26881 VVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNS 26940
Query: 644 GTYTCRAVNELGDASAEIQLAVGHAP 669
G Y + N +G ASA I++ + P
Sbjct: 26941 GCYELKLRNAMGSASATIRVQILDKP 26966
Score = 33.9 bits (76), Expect = 0.97
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 10/92 (10%)
Query: 958 RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL--LPSG--SLR 1013
RN NV Q A TL C+ G P P+V W + + + +Y + G L
Sbjct: 30935 RNLNVRYQSNA------TLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLI 30988
Query: 1014 LAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+A V D+ Y+ A+N GS S L V+
Sbjct: 30989 IASVTDDDATVYQVRATNQGGSVSGTASLEVE 31020
Score = 33.5 bits (75), Expect = 1.3
Identities = 27/97 (27%), Positives = 39/97 (40%), Gaps = 15/97 (15%)
Query: 963 PLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS---------GSL 1012
PLQ V G T + G P P V+W +D + + T LP L
Sbjct: 11 PLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTST-----LPGVQISFSDGRAKL 65
Query: 1013 RLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
+ V +SG Y A+N +G A+ L V+ T+
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA 102
Score = 33.5 bits (75), Expect = 1.3
Identities = 20/80 (25%), Positives = 34/80 (42%), Gaps = 3/80 (3%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD---AQGTLIIQGVAPEDAGNYSCQ 561
G +++ G P P I+W++E + L + R+ + + L I+ D G Y
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982
Query: 562 ATNEVGTDQETVTLYYTDPP 581
A N G Q + + D P
Sbjct: 17983 AKNSSGHAQGSAIVNVLDRP 18002
Score = 33.5 bits (75), Expect = 1.3
Identities = 35/172 (20%), Positives = 58/172 (33%), Gaps = 20/172 (11%)
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD 850
++ R LP+ WLK ++ + + ++ + A N A S
Sbjct: 25720 IVERRELPDGRWLK--------CNYTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEP 25771
Query: 851 VELVVQV-------PPRIHPTATHH---ITNEGVPASLPCVASGVPAPTITWTKETNALT 900
E + PPR+ + G + +G P P I+W K+ +
Sbjct: 25772 SESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIE 25831
Query: 901 SRGPHYNVSKEGTLLIAQPSA--QDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
R +S + L+ +D G YV T N G S + V KP
Sbjct: 25832 ERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP 25883
Score = 33.1 bits (74), Expect = 1.7
Identities = 21/73 (28%), Positives = 30/73 (41%), Gaps = 2/73 (2%)
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQV--GDS 1022
++T + GE L G P P V+W KD V + +L L +++ DS
Sbjct: 16827 KLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDS 16886
Query: 1023 GHYECTASNPAGS 1035
G Y N GS
Sbjct: 16887 GKYCVVVENSTGS 16899
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 4/90 (4%)
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
+V++G+ + +GRP PT+TW + DG PL R + + D L + +
Sbjct: 23240 SVQVGQDLKIEVPISGRPKPTITWTK-DGLPL---KQTTRINVTDSLDLTTLSIKETHKD 23295
Query: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
D Y NV G+ A ++ P
Sbjct: 23296 DGGQYGITVANVVGQKTASIEIVTLDKPDP 23325
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/117 (27%), Positives = 44/117 (37%), Gaps = 17/117 (14%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLR---------IPAAQE 640
++V GE L + G P P + W RG E+ E S+ +++ + A
Sbjct: 23635 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEI----EESARCEIKNTDFKALLIVKDAIR 23690
Query: 641 RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 697
D G Y RA N G S + + V P E P VT C T PP
Sbjct: 23691 IDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEK----CSLTWSPP 23743
Score = 33.1 bits (74), Expect = 1.7
Identities = 20/75 (26%), Positives = 32/75 (42%), Gaps = 3/75 (4%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL---LPSGSLRLAQVQVGDS 1022
+ AGE L+ + +G P P V W+KD + + R + + +L + D
Sbjct: 24717 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 24776
Query: 1023 GHYECTASNPAGSAS 1037
G Y SN G+ S
Sbjct: 24777 GQYILKLSNVGGTKS 24791
Score = 33.1 bits (74), Expect = 1.7
Identities = 41/163 (25%), Positives = 59/163 (36%), Gaps = 28/163 (17%)
Query: 884 GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMR 943
G P P + W K LT R S L+I + D+G Y T N G + +
Sbjct: 25133 GRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVN 25192
Query: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV-------TWTKDSRP 996
+ V P +A V L + + VTL E PPL+ + + R
Sbjct: 25193 VRVLDSP--------SAPVNLTIREVKKDSVTLSWE-----PPLIDGGAKITNYIVEKRE 25239
Query: 997 V-----PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
ITN + R+ +Q G S ++ ASN G
Sbjct: 25240 TTRKAYATITNN---CTKTTFRIENLQEGCSYYFRVLASNEYG 25279
Score = 33.1 bits (74), Expect = 1.7
Identities = 19/80 (23%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 561
G ++ + + G P P I W++ + L ++ + G T +I+ D+G Y+
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 29121
Query: 562 ATNEVGTDQETVTLYYTDPP 581
N GT +V + D P
Sbjct: 29122 VKNASGTKAVSVMVKVLDSP 29141
Score = 32.7 bits (73), Expect = 2.2
Identities = 31/112 (27%), Positives = 46/112 (41%), Gaps = 14/112 (12%)
Query: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLE------MILAPEGSSSGKLRIPAAQERDAGT 645
+ VG+ L GVP P+V W + + + + P GS KL I A D G
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS---KLEIRNAAHEDGGI 17286
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 697
Y+ N G + +++ V P PRD+ V R +C T + P
Sbjct: 17287 YSLTVENPAGSKTVSVKVLVLDKP---GPPRDLEVSEIRKD--SCYLTWKEP 17333
Score = 32.3 bits (72), Expect = 2.8
Identities = 20/75 (26%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSRHSIRADG---SLHLDRALQEHAGRYSCVATNTAGS 846
I + G+P P W K PL +R S+ + +L + + AG+Y+ N AG+
Sbjct: 20004 IPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGT 20063
Query: 847 QHRDVELVVQVPPRI 861
+ + + V P I
Sbjct: 20064 KEGTISIKVVGKPGI 20078
Score = 32.3 bits (72), Expect = 2.8
Identities = 32/159 (20%), Positives = 62/159 (38%), Gaps = 20/159 (12%)
Query: 436 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA----- 490
+W+++ G L S I+G+ + + A N+ G+ ++ +A
Sbjct: 21801 EWQIVTPPAG----LKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRML 21856
Query: 491 -PQVSIHTSSQHFSQGVEVKVSCSA------SGYPTPHISWSRESQALQEDSRIHVDAQG 543
P++ + + V ++ C+ G P P + W+R+ + + I +
Sbjct: 21857 PPEIELDADLRKV---VTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSY 21913
Query: 544 TLIIQG-VAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
TL+I G V D+G Y N G+ V + D P
Sbjct: 21914 TLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP 21952
Score = 32.3 bits (72), Expect = 2.8
Identities = 16/67 (23%), Positives = 29/67 (43%)
Query: 884 GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMR 943
G PAP + W ++ + + S L++ + D+G Y+ T N+ G S +
Sbjct: 21886 GRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVN 21945
Query: 944 LSVNTKP 950
+ V P
Sbjct: 21946 VRVLDTP 21952
Score = 32.3 bits (72), Expect = 2.8
Identities = 22/81 (27%), Positives = 33/81 (40%), Gaps = 3/81 (3%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNYSCQ 561
G V + G P P ISW ++ L+E + + + TL I+ E G Y+
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 27637
Query: 562 ATNEVGTDQETVTLYYTDPPS 582
N V +T+ PPS
Sbjct: 27638 LDNAVCRIAVPITVITLGPPS 27658
Score = 32.3 bits (72), Expect = 2.8
Identities = 23/83 (27%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 680 VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPED 739
++ G S + GRP P VTW + DG + R+ + S LF +
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFK-DGVEIEKRMNM---EITDVLGSTSLFVRDATRDH 28025
Query: 740 QAPYVCEARNVFGKVQAEARLIV 762
+ Y EA+N G +AE ++ V
Sbjct: 28026 RGVYTVEAKNASGSAKAEIKVKV 28048
Score = 32.0 bits (71), Expect = 3.7
Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 19/126 (15%)
Query: 594 VGEEAVLVCEASGVPPPRVI--WYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTY 646
VG A+ C S P I W + G + +P+ KL I Q DAG Y
Sbjct: 11132 VGSSAIFECLVS---PSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEY 11188
Query: 647 TCRAVNELG--DASAEIQLAVGHAPQ--LTELPRDVTVELGRSALLACRATGRPPPTVTW 702
TC V LG + ++ +L V P + L +VTV G+ L+C V W
Sbjct: 11189 TC--VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL--NKERDVVW 11244
Query: 703 RRGDGQ 708
R+ DG+
Sbjct: 11245 RK-DGK 11249
Score = 32.0 bits (71), Expect = 3.7
Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 2/69 (2%)
Query: 884 GVPAPTITWTKETNAL--TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE 941
G P PT+TW K L T R + L I + D+G Y TA N VG
Sbjct: 21091 GRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDV 21150
Query: 942 MRLSVNTKP 950
+ + V+ P
Sbjct: 21151 ITIQVHDIP 21159
Score = 31.6 bits (70), Expect = 4.8
Identities = 12/27 (44%), Positives = 16/27 (59%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTK 992
+T KAG ++ L G P P +TWTK
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTK 13726
Score = 31.6 bits (70), Expect = 4.8
Identities = 80/397 (20%), Positives = 141/397 (35%), Gaps = 48/397 (12%)
Query: 450 LADLSLEIS-GIIPTDGGRYQCVASNANGVTRASVW---LLVREA---PQVSIHTSSQHF 502
+ DL ++ G++P + A NA GV+ S ++ ++ P + + T
Sbjct: 14339 IKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIV 14398
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI-----HVDAQGTLIIQGVAPEDAGN 557
+G ++ + P P +SW ++ + ++ R+ H+ A L + DAG
Sbjct: 14399 IEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAH--LEVPKSVRADAGI 14456
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP------- 610
Y+ N++G+ ++ + P + + C+ + PP
Sbjct: 14457 YTITLENKLGSATASINVKVIGLPGPCKD-----IKASDITKSSCKLTWEPPEFDGGTPI 14511
Query: 611 --RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCR--AVNELGDASAEIQLAVG 666
V+ R P S KL G Y R AVN++G I+L
Sbjct: 14512 LHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVG-GGEYIELKNP 14570
Query: 667 HAPQLTELPRD--VTVELGRSALLACRATGRPPPTVTWRRGDGQPLG-----LRLGAGRG 719
Q + P D V VE+ A T +PP G + +G + G R
Sbjct: 14571 VIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPP----LYDGGSKIMGYIIEKIAKGEERW 14626
Query: 720 SRSRQPDSGVLFFESVAPEDQAPYV--CEARNVFGKVQAEARLIVTGHAPPQIASSA--- 774
R + +L + + E+ Y A N G + T P A
Sbjct: 14627 KRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILR 14686
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 811
++ V G ++L + +G P P W+KD + P
Sbjct: 14687 TSLEVKRGDEIALDASI-SGSPYPTITWIKDENVIVP 14722
Score = 31.6 bits (70), Expect = 4.8
Identities = 20/86 (23%), Positives = 34/86 (39%)
Query: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQ 1018
+AN +AG + L +G P P W+K + + + +L +
Sbjct: 28360 DANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCN 28419
Query: 1019 VGDSGHYECTASNPAGSASHRYVLGV 1044
D+G Y T N +GS S + + V
Sbjct: 28420 RNDAGKYTLTVENNSGSKSITFTVKV 28445
Score = 31.6 bits (70), Expect = 4.8
Identities = 33/134 (24%), Positives = 51/134 (38%), Gaps = 7/134 (5%)
Query: 567 GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM---IL 623
GT + T L Y D + V G L G P P W + G ++ +
Sbjct: 30123 GTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAM 30182
Query: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
+ +L I A D+GTY N+ G + I++ V +P E P +E
Sbjct: 30183 IATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGP----LEYD 30238
Query: 684 RSALLACRATGRPP 697
+ + R + RPP
Sbjct: 30239 DIQVRSVRVSWRPP 30252
Score = 31.2 bits (69), Expect = 6.3
Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 2/74 (2%)
Query: 409 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT--DGG 466
V + GE L V G P + W +D + L + ++AD S + T D G
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSG 21530
Query: 467 RYQCVASNANGVTR 480
Y A+N G +
Sbjct: 21531 AYTLTATNPGGFAK 21544
Score = 31.2 bits (69), Expect = 6.3
Identities = 28/106 (26%), Positives = 42/106 (39%), Gaps = 11/106 (10%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVGDS 1022
+ AGE +D + G P P + W K + + T R + + SL + DS
Sbjct: 22553 IVVHAGESFKVDADIYGKPIPTIQWIKGDQELSN-TARLEIKSTDFATSLSVKDAVRVDS 22611
Query: 1023 GHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLS 1068
G+Y A N AG S + V R P P +SG++
Sbjct: 22612 GNYILKAKNVAGERSVTVNVKVLDRPG-------PPEGPVVISGVT 22650
Score = 31.2 bits (69), Expect = 6.3
Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 8/119 (6%)
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPT--VRVLEGQPVSLPCIVLAGRPLPERH 801
V E + G V A+ R+ PP+I A V VL + + GRP PE
Sbjct: 25086 VGEPATLPGSVVAQERI-----EPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVK 25140
Query: 802 WLKDGRPLPPGSRHSIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
W K L ++ + + + L +D + +GRY+ N +GS+ V + V P
Sbjct: 25141 WEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSP 25199
Score = 31.2 bits (69), Expect = 6.3
Identities = 17/69 (24%), Positives = 27/69 (39%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
+ + G + L KG P P+ WTK+ + + L + + GDSG Y
Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTY 30205
Query: 1026 ECTASNPAG 1034
+ N G
Sbjct: 30206 DLVLENKCG 30214
Score = 30.8 bits (68), Expect = 8.2
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 2/104 (1%)
Query: 387 TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG- 445
TG Q P L P P V V GETA CRV G + W + +++ S
Sbjct: 1829 TGVTTDQKEKQKPDIVLYPEP-VRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRF 1887
Query: 446 RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 489
RV L+I D G + A N GV V L +++
Sbjct: 1888 RVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1931
Score = 30.8 bits (68), Expect = 8.2
Identities = 19/81 (23%), Positives = 34/81 (41%), Gaps = 7/81 (8%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPE----DAGNYSC 560
G+ +++ G P P ++W++++ L+ + I TL+I PE D G +
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLI---IPECNRYDTGKFVM 20847
Query: 561 QATNEVGTDQETVTLYYTDPP 581
N G V + D P
Sbjct: 20848 TIENPAGKKSGFVNVRVLDTP 20868
Score = 30.8 bits (68), Expect = 8.2
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC-----IVLAGRPLPERHWLKD- 805
G +AE R++ PP+I A +V+ + C + + GRP PE W +D
Sbjct: 21847 GTPKAEDRML-----PPEIELDADLRKVVT---IRACCTLRLFVPIKGRPAPEVKWARDH 21898
Query: 806 GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
G L S S + L + + +G+Y N++GS+ V + V P
Sbjct: 21899 GESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP 21952
Score = 30.8 bits (68), Expect = 8.2
Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 10/84 (11%)
Query: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD-----SRPVPPITNRYGLLPSGSLR 1013
+A++ VT +A + L KG P P V W +D + T+ Y LL G+
Sbjct: 21863 DADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGN-- 21920
Query: 1014 LAQVQVGDSGHYECTASNPAGSAS 1037
V DSG Y T N +GS S
Sbjct: 21921 ---VNRFDSGKYILTVENSSGSKS 21941
Score = 30.8 bits (68), Expect = 8.2
Identities = 35/157 (22%), Positives = 56/157 (35%), Gaps = 17/157 (10%)
Query: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELP------RDVTVELGRSALLACRATGRPPPT 699
+ +A NE G + + A LT P +++ G + GRP P
Sbjct: 24283 FRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPN 24342
Query: 700 VTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR 759
++W + DG+PL R + S VL + +D Y A N G
Sbjct: 24343 ISWVK-DGEPL---KQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLS 24398
Query: 760 LIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796
+IV + P V + VS +V++ P
Sbjct: 24399 VIV-------LEKPGPPVGPVRFDEVSADFVVISWEP 24428
Score = 30.8 bits (68), Expect = 8.2
Identities = 45/194 (23%), Positives = 67/194 (34%), Gaps = 22/194 (11%)
Query: 766 APPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA--DGSL 823
AP S ++E +PVS + + WLK + + ++ A +G
Sbjct: 28961 APAYDGGSKVVGYIIERKPVS---------EVGDGRWLKCNYTIVSDNFFTVTALSEGDT 29011
Query: 824 HLDRALQEHA-GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHH----ITNEGVPASL 878
+ R L ++A G S + +T RD PP+ A H G L
Sbjct: 29012 YEFRVLAKNAAGVISKGSESTGPVTCRDE----YAPPKAELDARLHGDLVTIRAGSDLVL 29067
Query: 879 PCVASGVPAPTITWTKETNA--LTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 936
G P P I WTK L + K T +I D+G Y T N G
Sbjct: 29068 DAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASG 29127
Query: 937 FSSQEMRLSVNTKP 950
+ + + V P
Sbjct: 29128 TKAVSVMVKVLDSP 29141
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 216 bits (549), Expect = 1e-55
Identities = 210/705 (29%), Positives = 301/705 (42%), Gaps = 70/705 (9%)
Query: 374 EGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV---LGEAPY 429
+ Y CTA + AG R+ ++ P V + G AV C + + E
Sbjct: 158 DNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Query: 430 NLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASN--------ANGVT 479
++W +D ++P + L IS + D Y+C+ + +NG
Sbjct: 218 VVSWEKDTVSIIPEHRFFITYHG--GLYISDVQKEDALSTYRCITKHKYSGETRQSNGA- 274
Query: 480 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
R SV P + SQ G V++ C+ASGYP P I W ++ + L DSR
Sbjct: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
Query: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
G L I + ED+G Y C+ TN G+ + T L DP V+ + +G +
Sbjct: 335 RITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
Query: 600 LVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNEL 654
L C +G P + WYR E++L E G S+ L I +AQ+ +G Y C A +
Sbjct: 394 LSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
Query: 655 GDAS--AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
A A I L G P++ + V G L C A G PPPTVTW D +P+ +
Sbjct: 453 QTAQDFAIIALEDG-TPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL-DDEPI-V 509
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
R G+ R ++ D + +V D Y C ARN+ G + +AR+ V G PP
Sbjct: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG--PPS 567
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHL-DRA 828
I + + + G+ + C V+ G P W KD LP R + +G+L L D
Sbjct: 568 IRAMR-NITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQ 625
Query: 829 LQEHAGRYSC-VATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPAS------LPCV 881
G Y C V S + V + V+VPP I P E PAS +PCV
Sbjct: 626 KGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-------EFPPASIGQLLYIPCV 678
Query: 882 ASGVPAP-TITWTKETNALTSRGPHYNVSKE--GTLLIAQPSAQDAGAYVCTATNTVGFS 938
S P ITW K+ + S SKE +L I+ S + G Y C A+N
Sbjct: 679 VSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATV 738
Query: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-------- 990
S+E +L V PR + + + KAG L+C G PPP V W
Sbjct: 739 SRERQLIVRVPPRFVVQPNNQDG----IYGKAG---VLNCSVDGYPPPKVMWKHAKGSGN 791
Query: 991 TKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
+ PV P+T R +LP+ SL + V D G+Y C ASN G+
Sbjct: 792 PQQYHPV-PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 835
Score = 202 bits (514), Expect = 2e-51
Identities = 192/712 (26%), Positives = 295/712 (41%), Gaps = 63/712 (8%)
Query: 376 TYEC-TAVSRAGTGRAK--AQIVVTDP----PPQLVPAPNVTVSPGETAVLSCRVLGEAP 428
TY C T +G R A++ VTDP P L + V G T L C G
Sbjct: 255 TYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPI 314
Query: 429 YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
+ W++D R LPA + ++ L+ IS + D G Y C +N G A+ L+V
Sbjct: 315 PAIRWLKDGRPLPADSRWTKRITGLT--ISDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
Query: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD--AQGTLI 546
+ V++ G V +SC+ +G P I W R ++ + D I + + TL+
Sbjct: 373 DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL 432
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAVLVCEA 604
I +G Y C AT + T Q+ + D P VS+ + V V GE+ L+C A
Sbjct: 433 ITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCAA 491
Query: 605 SGVPPPRVIW-------YRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNEL 654
G PPP V W R G +G++ + + Q RD G Y C A N +
Sbjct: 492 KGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
Query: 655 GDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
G A + ++ V P + + R++T GR L+ CR G P ++ W + L
Sbjct: 552 GSAEYQARINVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKD-------AL 603
Query: 715 GAGRGSRSRQPDSGVLFFESVAPE-DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS- 772
R ++G L V D+ Y+C + ++ + V PP I
Sbjct: 604 LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVL-IQPQLSISQSVHVAVKVPPLIQPF 662
Query: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD---GSLHLDRAL 829
P + GQ + +PC+V +G W KDG+ + GS +I + SL +
Sbjct: 663 EFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
Query: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
+H G Y+C+A+N A + R+ +L+V+VPPR + G L C G P P
Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780
Query: 890 ITWTKETNALTSRGPH-------YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQE 941
+ W + + H + +LLI +D G Y+C A+N VG S+
Sbjct: 781 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS 840
Query: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV-PPI 1000
M L+V I + + N + + A E L+C A+G P ++ W K + P
Sbjct: 841 MFLTVKIPAMI----TSHPNTTIAIKGHAKE---LNCTARGERPIIIRWEKGDTVIDPDR 893
Query: 1001 TNRYGLLPS-------GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
RY + +L+L GDS + C A N G L VQ
Sbjct: 894 VMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQ 945
Score = 156 bits (395), Expect = 1e-37
Identities = 157/615 (25%), Positives = 258/615 (41%), Gaps = 51/615 (8%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 432
+ GTY C + G+ A ++V DP + + G T +LSC + G + +
Sbjct: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
Query: 433 WVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGVTRASVWLLVREA 490
W R+ VLP + L++ +L I+ + G YQC A+ A ++ L
Sbjct: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
Query: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLI 546
P++ S + + G + + C+A G P P ++W+ + + + D + + + GT I
Sbjct: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
Query: 547 ----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
+ G D G Y C A N VG+ + + PPS+ A+ + VA G + ++ C
Sbjct: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA-GRDTLINC 586
Query: 603 EASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQE-RDAGTYTCRA-VNELG 655
G P + WY+ + +L P+ +G L++ Q+ D G Y C +
Sbjct: 587 RVIGYPYYSIKWYK---DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
Query: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RATGRPPPTVTWRRGDGQPLGLRL 714
S + +AV P L + +G+ + C ++G P +TWR+ DGQ +
Sbjct: 644 SISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK-DGQV--IIS 699
Query: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
G+G S++ S L SV+ + Y C A N V E +LIV PP+
Sbjct: 700 GSGVTIESKEFMSS-LQISSVSLKHNGNYTCIASNAAATVSRERQLIV--RVPPRFVVQP 756
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWL--------KDGRPLPPGSRHSIRADGSLHLD 826
+ G+ L C V G P P+ W + P+P R I + SL +
Sbjct: 757 NNQDGIYGKAGVLNCSV-DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 815
Query: 827 RALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRI--HPTATHHITNEGVPASLPCVAS 883
L+E G Y C A+N G+ + + L V++P I HP T I +G L C A
Sbjct: 816 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT--IAIKGHAKELNCTAR 873
Query: 884 GVPAPTITWTK-ETNALTSRGPHYNVSKE-------GTLLIAQPSAQDAGAYVCTATNTV 935
G I W K +T R Y ++ + TL + D+ + C A N+
Sbjct: 874 GERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSY 933
Query: 936 GFSSQEMRLSVNTKP 950
G ++L+V P
Sbjct: 934 GEDRGLIQLTVQEPP 948
Score = 152 bits (383), Expect = 2e-36
Identities = 166/597 (27%), Positives = 248/597 (41%), Gaps = 70/597 (11%)
Query: 502 FSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLIIQGVAPE------ 553
FS V V V C A+G P+ + W + HV A GTL + +P
Sbjct: 97 FSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI 156
Query: 554 DAGNYSCQATNEVG---TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPP 609
+Y C A N G + V + +P +V + + G AV C S V
Sbjct: 157 HDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSM--RGNVAVFKCLIPSSVQE 214
Query: 610 --PRVIWYRGGLEMILAPEG----SSSGKLRIPAAQERDA-GTYTCRAVNELGDASAEIQ 662
V W + + +I PE + G L I Q+ DA TY C ++ S E +
Sbjct: 215 YVSVVSWEKDTVSII--PEHRFFITYHGGLYISDVQKEDALSTYRCITKHKY---SGETR 269
Query: 663 LAVGHAPQLTELPRDVTVEL----------GRSALLACRATGRPPPTVTWRRGDGQPLGL 712
+ G +T+ + L G + L C A+G P P + W + DG+PL
Sbjct: 270 QSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK-DGRPL-- 326
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 772
SR + +G L + ED Y+CE N FG +A L+V P +
Sbjct: 327 ----PADSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID--PLHVTL 379
Query: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR--ADGSLHLDRALQ 830
+ ++ G V L C L G P W ++ + P SIR ++ +L + A +
Sbjct: 380 TPKKLKTGIGSTVILSC-ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
Query: 831 EHAGRYSCVATNTA-GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
H+G Y C AT A +Q + + PRI + + + N G SL C A G P PT
Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
Query: 890 ITWTKETNALTSRGPH----YNVSKEGTLL----IAQPSAQDAGAYVCTATNTVGFSSQE 941
+TW + + G H Y +S +GT + + P +D G Y CTA N VG + +
Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMS-DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
Query: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
R++V P I RN +TA AG + ++C G P + W KD+ +P
Sbjct: 558 ARINVRGPPSI--RAMRN------ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD-N 608
Query: 1002 NRYGLLPSGSLRLAQVQVG-DSGHYECTA-SNPAGSASHRYVLGVQGRTSWQPQSLP 1056
+R + +G+L+L VQ G D G Y C+ P S S + V+ QP P
Sbjct: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP 665
Score = 146 bits (369), Expect = 1e-34
Identities = 145/563 (25%), Positives = 231/563 (41%), Gaps = 36/563 (6%)
Query: 327 LLVSCSVHSALPFRLQ-LRRGEARLGEER-HFQESGNSSWEILRASKAEEGTYECTAVSR 384
+++SC++ + F ++ R E L +E + N + I A K+ G Y+C A +
Sbjct: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
Query: 385 AGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443
A T + A I + D P++V + V+PGE L C G P +TW D +
Sbjct: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
Query: 444 TGRVAQLADLS-------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 496
+S + ++G DGG Y+C A N G + VR P +
Sbjct: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
Query: 497 TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP-EDA 555
+ + G + ++C GYP I W +++ L ++ R V GTL + V D
Sbjct: 572 RNITAVA-GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDE 630
Query: 556 GNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 613
G Y C + ++V + PP + ++G+ + C +SG P R+
Sbjct: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRIT 689
Query: 614 WYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 667
W + G ++I++ G + L+I + + G YTC A N S E QL V
Sbjct: 690 WRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
Query: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWR--RGDGQPLGLRLGAGRGSRSRQP 725
P+ P + G++ +L C G PPP V W+ +G G P G P
Sbjct: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
Query: 726 DSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPV 785
+S +L V ED Y+C+A N G + +T P I S T ++G
Sbjct: 809 NSSLL-IRHVLEEDIGYYLCQASNGVG-TDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
Query: 786 SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRAD-------GSLHLDRALQEHAGRY 836
L C RP+ R W K + P R++I +L L A + + +
Sbjct: 867 ELNCTARGERPIIIR-WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFF 925
Query: 837 SCVATNTAGSQHRDVELVVQVPP 859
SC A N+ G ++L VQ PP
Sbjct: 926 SCHAINSYGEDRGLIQLTVQEPP 948
Score = 129 bits (323), Expect = 2e-29
Identities = 160/614 (26%), Positives = 234/614 (38%), Gaps = 63/614 (10%)
Query: 468 YQCVASNANGVTRAS---VWLLVREAPQVSIHTSSQHFSQGVEVKVSC----SASGYPTP 520
Y C A NA G R+ V + RE ++ Q +G C S Y +
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Query: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDA-GNYSCQATNEVGTDQET---VTLY 576
+SW +++ ++ + R + G L I V EDA Y C ++ + L
Sbjct: 219 -VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
Query: 577 YTDP----PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK 632
TDP P++ V G L C ASG P P + W + G + P S K
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL---PADSRWTK 334
Query: 633 ----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
L I + D+GTY C N G A A L V +T P+ + +G + +L
Sbjct: 335 RITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVIL 394
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
+C TG P T+ W R L + RG + L S Y C A
Sbjct: 395 SCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-----TLLITSAQKSHSGAYQCFAT 449
Query: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRP 808
Q A +I P+I SS V G+ SL C G P P W D P
Sbjct: 450 RKAQTAQDFA-IIALEDGTPRIVSSFSEKVVNPGEQFSLMCAA-KGAPPPTVTWALDDEP 507
Query: 809 LPPGSRHSIR----ADGS----LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 860
+ H +DG+ +++ G Y C A N GS + V+ PP
Sbjct: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
Query: 861 IHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQ- 918
I A +IT G + C G P +I W K+ L V + GTL +
Sbjct: 568 IR--AMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQV-VFENGTLKLTDV 624
Query: 919 PSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVPLQVT-AKAGEEVTL 976
D G Y+C+ S SQ + ++V P I P + A G+ + +
Sbjct: 625 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ---------PFEFPPASIGQLLYI 675
Query: 977 DCE-AKGSPPPLVTWTKDSRPVPPITNRYGLLPS----GSLRLAQVQVGDSGHYECTASN 1031
C + G P +TW KD + + I+ + S SL+++ V + +G+Y C ASN
Sbjct: 676 PCVVSSGDMPIRITWRKDGQVI--ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
Query: 1032 PAGSASHRYVLGVQ 1045
A + S L V+
Sbjct: 734 AAATVSRERQLIVR 747
Score = 118 bits (296), Expect = 3e-26
Identities = 94/390 (24%), Positives = 164/390 (42%), Gaps = 24/390 (6%)
Query: 309 GAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR 368
G P + I + L++C V + ++ + L + N + ++
Sbjct: 564 GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTD 623
Query: 369 ASKA-EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GE 426
K +EG Y C+ + + +++ V PP + P S G+ + C V G+
Sbjct: 624 VQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
Query: 427 APYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVW 484
P +TW +D +V+ + +G + + SL+IS + G Y C+ASNA
Sbjct: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
Query: 485 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS--------RESQALQEDSR 536
L+VR P+ + ++Q G ++CS GYP P + W ++ + R
Sbjct: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
Query: 537 IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVG 595
I + +L+I+ V ED G Y CQA+N VGTD +++ L P +++ + G
Sbjct: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG 863
Query: 596 EEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSS---GKLRIPAAQERDAG 644
L C A G P + W +G + +A + + L++ A D+
Sbjct: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
Query: 645 TYTCRAVNELGDASAEIQLAVGHAPQLTEL 674
++C A+N G+ IQL V P EL
Sbjct: 924 FFSCHAINSYGEDRGLIQLTVQEPPDPPEL 953
Score = 59.3 bits (142), Expect = 2e-08
Identities = 33/76 (43%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 878 LPCVASGVPAPTITWTK--ETNAL-TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 934
LPC + G PAP + WTK E +A+ S H + GTLL+ A+D+G Y CTATNT
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 935 VGFSSQEMRLSVNTKP 950
GF + + L V P
Sbjct: 1429 GGFDTIIVNLLVQVPP 1444
Score = 56.6 bits (135), Expect = 1e-07
Identities = 42/121 (34%), Positives = 54/121 (44%), Gaps = 10/121 (8%)
Query: 764 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR----PLPPGSRHSIRA 819
G AP +I S TV + V LPC + G P P W KD P+ I
Sbjct: 1346 GKAPAKIISFGGTVTTPWMKDVRLPCNSV-GDPAPAVKWTKDSEDSAIPVSMDGHRLIHT 1404
Query: 820 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP-----RIHPTATHHITNEGV 874
+G+L L E +G Y+C ATNT G V L+VQVPP + T+ IT +
Sbjct: 1405 NGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI 1464
Query: 875 P 875
P
Sbjct: 1465 P 1465
Score = 53.9 bits (128), Expect = 9e-07
Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 4/79 (5%)
Query: 507 EVKVSCSASGYPTPHISWSRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQA 562
+V++ C++ G P P + W+++S+ + D + GTL+++ V ED+G Y+C A
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
Query: 563 TNEVGTDQETVTLYYTDPP 581
TN G D V L PP
Sbjct: 1426 TNTGGFDTIIVNLLVQVPP 1444
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/72 (40%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSR--PVPPITNRYGLL-PSGSLRLAQVQVGDS 1022
VT ++V L C + G P P V WTKDS +P + + L+ +G+L L V+ DS
Sbjct: 1359 VTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDS 1418
Query: 1023 GHYECTASNPAG 1034
G+Y CTA+N G
Sbjct: 1419 GYYTCTATNTGG 1430
Score = 39.3 bits (90), Expect = 0.023
Identities = 48/209 (22%), Positives = 74/209 (35%), Gaps = 29/209 (13%)
Query: 511 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ 570
S SG P P + Q + ++ Q L + V GN S + T E
Sbjct: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL--APEGS 628
P + + V ++ L C + G P P V W + + + + +G
Sbjct: 1349 ---------PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
Query: 629 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684
++G L + A + D+G YTC A N G + + L V P + PR
Sbjct: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP---DQPR-------- 1448
Query: 685 SALLACRATGRPPPTVTWRRGDGQPLGLR 713
L T T+TW GD +R
Sbjct: 1449 ---LTVSKTSASSITLTWIPGDNGGSSIR 1474
Score = 34.3 bits (77), Expect = 0.74
Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 7/135 (5%)
Query: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---PPQLVPAPNVTVSPGETAV-L 419
+ I ++ ++ AV+ AG G + ++ + P +++ +P V L
Sbjct: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1369
Query: 420 SCRVLGEAPYNLTWVRDWR--VLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNAN 476
C +G+ + W +D +P S G + +L + + D G Y C A+N
Sbjct: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
Query: 477 GVTRASVWLLVREAP 491
G V LLV+ P
Sbjct: 1430 GFDTIIVNLLVQVPP 1444
Score = 32.7 bits (73), Expect = 2.2
Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 5/100 (5%)
Query: 655 GDASAEIQLA-VGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 712
G++S ++ + G AP ++ VT + L C + G P P V W + D + +
Sbjct: 1334 GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTK-DSEDSAI 1392
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 752
+ G R + G L +V ED Y C A N G
Sbjct: 1393 PVSMD-GHRLIHTN-GTLLLRAVKAEDSGYYTCTATNTGG 1430
Score = 32.0 bits (71), Expect = 3.7
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 15/70 (21%)
Query: 366 ILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
+LRA KAE+ G Y CTA + G ++V PP Q P +TVS + ++
Sbjct: 1409 LLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ----PRLTVSKTSASSIT---- 1460
Query: 425 GEAPYNLTWV 434
LTW+
Sbjct: 1461 ------LTWI 1464
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 211 bits (538), Expect = 3e-54
Identities = 192/704 (27%), Positives = 286/704 (40%), Gaps = 62/704 (8%)
Query: 373 EEGTYECTAVSRAG-TGRAK----AQIVVTDP----PPQLVPAPNVTVSPGETAVLSCRV 423
E+G Y ++R TG + A++ V+DP P L + G+ L C+
Sbjct: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKA 248
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
LG + W++D L S GR Q L I I P+D G Y C SN G +
Sbjct: 249 LGHPEPDYRWLKDNMPLELS-GRF-QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIG 306
Query: 484 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-- 541
L V++ + +I S G +V +SCS +G +SW R + L + +
Sbjct: 307 RLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN 366
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAV 599
LI+ + D G Y C + + Q+ V + D P +SA + V V+ E
Sbjct: 367 HENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVS 425
Query: 600 LVCEASGVPPPRVIW-------YRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCR 649
L+C G P P + W +GG + ++ EG+ L I ++Q RD G Y C
Sbjct: 426 LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
Query: 650 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ- 708
A N G + ++ V P +++T GR + CR G P ++ W +
Sbjct: 486 ANNSAGVVLYQARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL 544
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPE-DQAPYVCEARNVFGKVQAEARLIVTGHAP 767
P R A ++G L V E D+ Y C V ++ + VT P
Sbjct: 545 PFNHRQVAFE-------NNGTLKLSDVQKEVDEGEYTCNVL-VQPQLSTSQSVHVTVKVP 596
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG---SRHSIRADGSLH 824
P I R GQ V +PC+V++G W KDGRP+P + +I SL
Sbjct: 597 PFI-QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR 655
Query: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASG 884
+ H G Y+C+A N A + +L+V+VPP+ G L C A G
Sbjct: 656 ISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEG 715
Query: 885 VPAPTITWTKETNALTSR------GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 938
P PTI W A + V G+LLI +D+G Y+C +N VG
Sbjct: 716 YPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
Query: 939 -SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
S+ M L+V I + P A G++ + C A G P +V W K+ R +
Sbjct: 776 VSKSMYLTVKIPAMI-------TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRII 828
Query: 998 PPITNRY-------GLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
P RY G +L++ DSG + C A N G
Sbjct: 829 NPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG 872
Score = 179 bits (453), Expect = 2e-44
Identities = 184/696 (26%), Positives = 280/696 (40%), Gaps = 52/696 (7%)
Query: 374 EGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 432
+ TY CTA + +G R++ I P V + G AV C + +T
Sbjct: 97 DNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT 156
Query: 433 ---WVRDWRVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASNA-NGVTRAS--VWL 485
W +D V S R + +L I + DG Y+C+ + G TR S L
Sbjct: 157 VVSWEKD-TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
Query: 486 LVRE----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541
V + AP + + G V++ C A G+P P W +++ L+ R
Sbjct: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV 275
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
G L+I+ + P D+G+Y C+ +N GT + LY P + V +VG + L
Sbjct: 276 TG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
Query: 602 CEASGVPPPRVIWYRGGLEMILAP------EGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
C +G + WYR G IL P G + L + + D G Y C +
Sbjct: 335 CSVTGTEDQELSWYRNG--EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL 392
Query: 656 DASAEIQLAV-GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
A +Q+ + P++ + V L C G P PT+TW D P+ L+
Sbjct: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTL-DDDPI-LKG 450
Query: 715 GAGRGSRSRQPDSGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA 771
G+ R S+ + V+ + +++ D Y C A N G V +AR+ V G P
Sbjct: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG---PASI 507
Query: 772 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH-SIRADGSLHLDRALQ 830
+ + G+ + C V+ G P W K+ LP R + +G+L L +
Sbjct: 508 RPMKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
Query: 831 E-HAGRYSC-VATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPA 887
E G Y+C V S + V + V+VPP I P + G +PC V SG
Sbjct: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRF-SIGQRVFIPCVVVSGDLP 625
Query: 888 PTITWTKETNALT-SRGPHY-NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLS 945
TITW K+ + S G N+ +L I+ S G Y C A N + +L
Sbjct: 626 ITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLI 685
Query: 946 VNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP------ 999
V P+ + P G+ V L+C A+G P P + W P
Sbjct: 686 VRVPPKFVVQ-------PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA 738
Query: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
+ R +L +GSL + V DSG+Y C SN G+
Sbjct: 739 LNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
Score = 160 bits (405), Expect = 7e-39
Identities = 148/615 (24%), Positives = 252/615 (40%), Gaps = 50/615 (8%)
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 431
++ G+Y C +R GT + ++ V P + V S G LSC V G L
Sbjct: 286 SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQEL 345
Query: 432 TWVRDWRVL-PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE- 489
+W R+ +L P R+ + +L + ++ +DGG YQC + V +++ +
Sbjct: 346 SWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDG 405
Query: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIH--VDAQGTL 545
P++ S + S V + C+ G P P I+W+ + + + RI + ++G +
Sbjct: 406 TPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNV 465
Query: 546 I----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
+ I D G Y C A N G + P S+ + + +A G + +
Sbjct: 466 VSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA-GRDTYIH 524
Query: 602 CEASGVPPPRVIWYRGGLEMILAPEG------SSSGKLRIPAAQ-ERDAGTYTCRA-VNE 653
C G P + WY+ L P ++G L++ Q E D G YTC V
Sbjct: 525 CRVIGYPYYSIKWYKNS---NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQP 581
Query: 654 LGDASAEIQLAVGHAP--QLTELPRDVTVELGRSALLAC-RATGRPPPTVTWRRGDGQPL 710
S + + V P Q E PR +G+ + C +G P T+TW++ DG+P+
Sbjct: 582 QLSTSQSVHVTVKVPPFIQPFEFPR---FSIGQRVFIPCVVVSGDLPITITWQK-DGRPI 637
Query: 711 GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQI 770
LG + + L +++ Y C ARN V+ +++LIV PP+
Sbjct: 638 PGSLGV---TIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV--RVPPKF 692
Query: 771 ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW-------LKDGRPLPPGSRHSIRADGSL 823
+ G+ V L C G P+P W + +P+ R + ++GSL
Sbjct: 693 VVQPRDQDGIYGKAVILNCSA-EGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSL 751
Query: 824 HLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 882
+ ++E +G Y C +N G+ + + L V++P I + +G + C A
Sbjct: 752 LIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTA 811
Query: 883 SGVPAPTITWTKETNALTSRGPHYNVSKE-------GTLLIAQPSAQDAGAYVCTATNTV 935
G + W KE + Y VS + TL I +D+G + C A N+
Sbjct: 812 HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSY 871
Query: 936 GFSSQEMRLSVNTKP 950
G ++L+V P
Sbjct: 872 GEDRGIIQLTVQEPP 886
Score = 149 bits (377), Expect = 1e-35
Identities = 178/689 (25%), Positives = 273/689 (39%), Gaps = 70/689 (10%)
Query: 393 QIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD 452
++V LVP P + P + GE Y++ +R V P T ++
Sbjct: 33 EVVFASTTGTLVPCPAAGIPP--VTLRWYLATGEEIYDVPGIR--HVHPNGTLQIFPFPP 88
Query: 453 LSLEISGIIPTDGGRYQCVASNANGVTRAS---VWLLVREAPQVSIHTSSQHFSQGVEVK 509
S S +I + Y C A N +G R+ + ++RE ++ Q +G
Sbjct: 89 SSF--STLIHDN--TYYCTAENPSGKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAV 142
Query: 510 VSC----SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDA-GNYSC---- 560
C S Y T +SW +++ +L SR + + G L I+ V ED NY C
Sbjct: 143 FKCIIPSSVEAYITV-VSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRH 201
Query: 561 QATNEVGTDQETVTLYYTDP----PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 616
+ T E + L+ +DP PS+ G+ L C+A G P P W +
Sbjct: 202 RYTGET-RQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK 260
Query: 617 GGLEMILAPEGSSSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 675
+ + L+ + L I + D+G+Y C N G A +L V + T P
Sbjct: 261 DNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320
Query: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV 735
R V +G L+C TG ++W R G L G+ R + L + +
Sbjct: 321 RKVKSSVGSQVSLSCSVTGTEDQELSWYRN-----GEILNPGKNVRITGINHENLIMDHM 375
Query: 736 APEDQAPYVCEARNVFGKVQAEARL-IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAG 794
D Y C R K+ A+ + +V P+I S+ V +PVSL C V G
Sbjct: 376 VKSDGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNV-KG 432
Query: 795 RPLPERHWLKDGRPLPPGSRHSIR----ADGS----LHLDRALQEHAGRYSCVATNTAGS 846
PLP W D P+ G H I ++G+ L++ + G Y C A N+AG
Sbjct: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
Query: 847 QHRDVELVVQVPPRIHPTATHHITN-EGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ V+ P I P +IT G + C G P +I W K +N L
Sbjct: 493 VLYQARINVRGPASIRPMK--NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQ 550
Query: 906 YNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVP 963
GTL ++ + D G Y C S SQ + ++V P I P
Sbjct: 551 VAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ---------P 601
Query: 964 LQVTA-KAGEEVTLDCEA-KGSPPPLVTWTKDSRPVP-----PITNRYGLLPSGSLRLAQ 1016
+ G+ V + C G P +TW KD RP+P I N + + SLR++
Sbjct: 602 FEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDN---IDFTSSLRISN 658
Query: 1017 VQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
+ + +G+Y C A N A + H+ L V+
Sbjct: 659 LSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
Score = 149 bits (375), Expect = 2e-35
Identities = 141/559 (25%), Positives = 228/559 (40%), Gaps = 33/559 (5%)
Query: 329 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL--RASKAEEGTYECTAVSRAG 386
+SCSV L R L ++ + +G + ++ K++ G Y+C
Sbjct: 333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL 392
Query: 387 TGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTW-VRDWRVLPAST 444
+ + Q+V+ D P+++ A VSP E L C V G +TW + D +L +
Sbjct: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
Query: 445 GRVAQLADLS------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 498
R++Q+ L IS DGG Y+C A+N+ GV + VR + +
Sbjct: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 512
Query: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHVDAQGTLIIQGVAPE-DAG 556
+ G + + C GYP I W + S L + R + + GTL + V E D G
Sbjct: 513 ITAIA-GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEG 571
Query: 557 NYSCQ--ATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 613
Y+C ++ T Q +V + PP + ++G+ + C SG P +
Sbjct: 572 EYTCNVLVQPQLSTSQ-SVHVTVKVPPFIQPFE-FPRFSIGQRVFIPCVVVSGDLPITIT 629
Query: 614 WYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHA 668
W + G + + + LRI G YTC A NE + QL V
Sbjct: 630 WQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVP 689
Query: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
P+ PRD G++ +L C A G P PT+ W+ G + R + +G
Sbjct: 690 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 749
Query: 729 VLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLP 788
L + V ED Y+C+ N G + +T P I S T +GQ +
Sbjct: 750 SLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 808
Query: 789 CIVLAGRPLPERHWLKDGRPL-PPGSRHSIRAD-------GSLHLDRALQEHAGRYSCVA 840
C +P+ R W K+ R + P +R+ + +L + ++E +G +SC A
Sbjct: 809 CTAHGEKPIIVR-WEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHA 867
Query: 841 TNTAGSQHRDVELVVQVPP 859
N+ G ++L VQ PP
Sbjct: 868 INSYGEDRGIIQLTVQEPP 886
Score = 128 bits (322), Expect = 3e-29
Identities = 91/327 (27%), Positives = 144/327 (44%), Gaps = 25/327 (7%)
Query: 371 KAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GEAPY 429
+ +EG Y C + + +++ V PP + P S G+ + C V+ G+ P
Sbjct: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPI 626
Query: 430 NLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 487
+TW +D R +P S G D SL IS + G Y C+A N L+V
Sbjct: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
Query: 488 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS-------RESQALQEDSRIHVD 540
R P+ + Q G V ++CSA GYP P I W + Q + + RI V
Sbjct: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
Query: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
+ G+L+I+ V ED+G Y C+ +N+VG D +++ L P +++ L G++
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 806
Query: 600 LVCEASGVPPPRVIWYRGGLEMILAPEGSSS------------GKLRIPAAQERDAGTYT 647
+ C A G P V W + + I+ PE + L+I D+G ++
Sbjct: 807 MSCTAHGEKPIIVRWEKE--DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFS 864
Query: 648 CRAVNELGDASAEIQLAVGHAPQLTEL 674
C A+N G+ IQL V P E+
Sbjct: 865 CHAINSYGEDRGIIQLTVQEPPDPPEI 891
Score = 114 bits (284), Expect = 7e-25
Identities = 115/447 (25%), Positives = 184/447 (41%), Gaps = 22/447 (4%)
Query: 343 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 402
L+ G R+ + + + S I + + G Y CTA + AG +A+I V P
Sbjct: 448 LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PAS 506
Query: 403 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI-I 461
+ P N+T G + CRV+G Y++ W ++ +LP + +VA + +L++S +
Sbjct: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
Query: 462 PTDGGRYQC-VASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC-SASGYPT 519
D G Y C V T SV + V+ P + FS G V + C SG
Sbjct: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ-PFEFPRFSIGQRVFIPCVVVSGDLP 625
Query: 520 PHISWSRESQALQEDSRI---HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
I+W ++ + + + ++D +L I ++ GNY+C A NE + L
Sbjct: 626 ITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLI 685
Query: 577 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW---YRGGLEMI--LAPEGS--- 628
PP G+ +L C A G P P ++W G+ +A G
Sbjct: 686 VRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQV 745
Query: 629 -SSGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSA 686
S+G L I E D+G Y C+ N++G D S + L V +T P G+
Sbjct: 746 LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKK 805
Query: 687 LLACRATGRPPPTVTWRRGDG--QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 744
++C A G P V W + D P R + S + +V ED +
Sbjct: 806 EMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVR-EDSGFFS 864
Query: 745 CEARNVFGKVQAEARLIVTGHA-PPQI 770
C A N +G+ + +L V PP+I
Sbjct: 865 CHAINSYGEDRGIIQLTVQEPPDPPEI 891
Score = 108 bits (271), Expect = 2e-23
Identities = 130/508 (25%), Positives = 195/508 (38%), Gaps = 63/508 (12%)
Query: 583 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSGKLRI--- 635
V+A V+ A ++ C A+G+PP + WY E I G +G L+I
Sbjct: 27 VNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPF 86
Query: 636 -PAAQER--DAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 691
P++ TY C A N G S ++ + T D G A+ C
Sbjct: 87 PPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCI 146
Query: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA-PYVCEARNV 750
+T + + L GSR +G L+ + V ED Y C R+
Sbjct: 147 IPSSVEAYITVVSWEKDTVSLV----SGSRFLITSTGALYIKDVQNEDGLYNYRCITRHR 202
Query: 751 FG---KVQAEARLIVT--GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
+ + ARL V+ ++ P I + + GQ V LPC L G P P+ WLKD
Sbjct: 203 YTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKAL-GHPEPDYRWLKD 261
Query: 806 GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA 865
PL R G L ++ +G Y C +N G+ L V+ P + +
Sbjct: 262 NMPLELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320
Query: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG----TLLIAQPSA 921
++ G SL C +G ++W + L P NV G L++
Sbjct: 321 RKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN---PGKNVRITGINHENLIMDHMVK 377
Query: 922 QDAGAYVCTATNTVGFSSQEMRLSVNT-KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
D GAY C + +++ + P+I S P E V+L C
Sbjct: 378 SDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSP-------AEPVSLMCNV 430
Query: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQV----------------QVGDSGH 1024
KG+P P +TWT D P+ L GS R++Q+ QV D G
Sbjct: 431 KGTPLPTITWTLDDDPI---------LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGV 481
Query: 1025 YECTASNPAGSASHRYVLGVQGRTSWQP 1052
Y CTA+N AG ++ + V+G S +P
Sbjct: 482 YRCTANNSAGVVLYQARINVRGPASIRP 509
Score = 53.9 bits (128), Expect = 9e-07
Identities = 35/98 (35%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 766 APPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP----GSRHSIRADG 821
AP +I + + TV + + LPC + G P P W+KD P R SI ++G
Sbjct: 1284 APARILTFSGTVTTPWMKDIVLPCKAV-GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG 1342
Query: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
S + E +G YSC+A N GS + L VQVPP
Sbjct: 1343 SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 53.1 bits (126), Expect = 2e-06
Identities = 28/73 (38%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP---PITNRYGLLPSGSLRLAQVQVGDS 1022
VT +++ L C+A G P P V W KDS P I R + +GS + V+ DS
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDS 1354
Query: 1023 GHYECTASNPAGS 1035
G+Y C A+N GS
Sbjct: 1355 GYYSCIANNNWGS 1367
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 507 EVKVSCSASGYPTPHISWSRESQALQE----DSRIHVDAQGTLIIQGVAPEDAGNYSCQA 562
++ + C A G P+P + W ++S D R + + G+ II+ V ED+G YSC A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 563 TNEVGTDQETVTLYYTDPP 581
N G+D+ + L PP
Sbjct: 1362 NNNWGSDEIILNLQVQVPP 1380
Score = 49.3 bits (116), Expect = 2e-05
Identities = 37/136 (27%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 839 VATNTAG----SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 894
VA +AG S+ VE + + P RI + T LPC A G P+P + W K
Sbjct: 1262 VAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
Query: 895 ETN---ALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNT--- 948
++N +L + ++ G+ +I A+D+G Y C A N G + L V
Sbjct: 1322 DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
Query: 949 KPRIHMNGSRNANVPL 964
+PR+ ++ + ++++ L
Sbjct: 1382 QPRLTVSKTTSSSITL 1397
Score = 41.2 bits (95), Expect = 0.006
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 12/161 (7%)
Query: 356 FQESGNS-SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPG 414
F+ S +S S+ I S+ + + AV+ AG G + ++T P PA +T S
Sbjct: 1237 FEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE--IITVEPLAKAPARILTFSGT 1294
Query: 415 ETA------VLSCRVLGEAPYNLTWVRDWRVLPAST---GRVAQLADLSLEISGIIPTDG 465
T VL C+ +G+ + W++D P+ GR + ++ S I + D
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDS 1354
Query: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV 506
G Y C+A+N G + L V+ P T S+ S +
Sbjct: 1355 GYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSI 1395
Score = 37.0 bits (84), Expect = 0.11
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 20/140 (14%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS----SSGKL 633
P + + V ++ VL C+A G P P V W + G ++ +G S+G
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSF 1344
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 693
I + D+G Y+C A N G + L V P + PR +TV S+ +
Sbjct: 1345 IIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP---DQPR-LTVSKTTSSSI----- 1395
Query: 694 GRPPPTVTWRRGDGQPLGLR 713
T++W GD +R
Sbjct: 1396 -----TLSWLPGDNGGSSIR 1410
Score = 35.0 bits (79), Expect = 0.43
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 678 VTVELGRSALLACRATGRPPPTVTWRR-GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
VT + +L C+A G P P V W + +G P + + R S +G +V
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFS----NGSFIIRTVK 1350
Query: 737 PEDQAPYVCEARNVFG 752
ED Y C A N +G
Sbjct: 1351 AEDSGYYSCIANNNWG 1366
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 195 bits (495), Expect = 3e-49
Identities = 127/379 (33%), Positives = 174/379 (45%), Gaps = 16/379 (4%)
Query: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
P++T P+D V G + CRA G P P + W R + + L SR D G
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE-----LSMKTDSRLNLLDDG 300
Query: 729 VLFFESVAPEDQAPYVCEARNVFGKVQA-EARLIVTGH-APPQIASSAPTVRVLEGQPVS 786
L ++ DQ Y C A+NV G+V+ E L G A P VL G+ V+
Sbjct: 301 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
Query: 787 LPCIVLAGRPLPERHWLKDGR-PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
L C G P P W + R PLP R +I G L++ +Q +G Y+C ATN
Sbjct: 361 LECSA-TGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID 419
Query: 846 SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
S H ++VQ P+ T + EG C A G P P I WTK + L+ H
Sbjct: 420 SVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH 479
Query: 906 YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ 965
V GTL I+ + D G Y C A N +G SQ++ + +PR+ A++P
Sbjct: 480 L-VLSSGTLRISGVALHDQGQYECQAVNIIG--SQKVVAHLTVQPRV---TPVFASIPSD 533
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
T + G V L C ++G P P +TW KD V + ++ + P G L + V D+G Y
Sbjct: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE-SGKFHISPEGFLTINDVGPADAGRY 592
Query: 1026 ECTASNPAGSASHRYVLGV 1044
EC A N GSAS VL V
Sbjct: 593 ECVARNTIGSASVSMVLSV 611
Score = 187 bits (475), Expect = 5e-47
Identities = 154/493 (31%), Positives = 203/493 (41%), Gaps = 44/493 (8%)
Query: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYT 647
V G C A G P P +IW R E+ + + G L I QE D G Y
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
Query: 648 CRAVNELGDASA-EIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPPTVTWR 703
C A N G+ E+ L +P P++ V +G S L C ATG PPP ++W
Sbjct: 317 CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWT 376
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
RGD PL + R SG L+ ++V D Y C A N V A A +IV
Sbjct: 377 RGDRTPLPV------DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV- 429
Query: 764 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 823
A PQ + V+EGQ V C G P P W K G L RH + + G+L
Sbjct: 430 -QALPQFTVTPQDRVVIEGQTVDFQCEA-KGNPPPVIAWTKGGSQLSVDRRHLVLSSGTL 487
Query: 824 HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPT----ATHHITNEGVPASLP 879
+ G+Y C A N GSQ L VQ PR+ P + G LP
Sbjct: 488 RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ--PRVTPVFASIPSDTTVEVGANVQLP 545
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
C + G P P ITW K+ +T G +++S EG L I DAG Y C A NT+G +S
Sbjct: 546 CSSQGEPEPAITWNKDGVQVTESGK-FHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
Query: 940 QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999
M LSVN P + NG P T+ T+D + L DSRP P
Sbjct: 605 VSMVLSVNV-PDVSRNGD-----PFVATSIVEAIATVDRAINSTRTHLF----DSRPRSP 654
Query: 1000 ----ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSL 1055
RY P + Q + G+ +E T H ++ + G TS+ L
Sbjct: 655 NDLLALFRY---PRDPYTVEQARAGEI--FERTLQLIQEHVQHGLMVDLNG-TSYHYNDL 708
Query: 1056 PVPHHPACLSGLS 1068
P + ++ LS
Sbjct: 709 VSPQYLNLIANLS 721
Score = 184 bits (466), Expect = 6e-46
Identities = 131/381 (34%), Positives = 168/381 (44%), Gaps = 21/381 (5%)
Query: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL--QEDSRIHVDAQGTLI 546
E P+++ + G V +C A G P P I W R + L + DSR+++ GTL+
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
Query: 547 IQGVAPEDAGNYSCQATNEVG-TDQETVTLYYTDPPS-----VSAVNAVVLVAVGEEAVL 600
IQ D G Y C A N G + VTL Y P+ + N VLV GE L
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV--GESVTL 361
Query: 601 VCEASGVPPPRVIWYRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 657
C A+G PPPR+ W RG L + + SG L I + D+G Y C A N +
Sbjct: 362 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
Query: 658 SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAG 717
A + V PQ T P+D V G++ C A G PPP + W +G G +L
Sbjct: 422 HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG-----GSQLSVD 476
Query: 718 RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 777
R R SG L VA DQ Y C+A N+ G + A L V P AS
Sbjct: 477 R--RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
Query: 778 RVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYS 837
V G V LPC G P P W KDG + + I +G L ++ AGRY
Sbjct: 535 TVEVGANVQLPC-SSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYE 593
Query: 838 CVATNTAGSQHRDVELVVQVP 858
CVA NT GS + L V VP
Sbjct: 594 CVARNTIGSASVSMVLSVNVP 614
Score = 170 bits (430), Expect = 9e-42
Identities = 126/424 (29%), Positives = 178/424 (41%), Gaps = 28/424 (6%)
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSP-------GETAVLSCRV 423
AE G + A+ R + + V T P +L P +T P G T +CR
Sbjct: 211 AESGNAQAAAICEYPR-RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA 269
Query: 424 LGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 482
G + W+R+ L T R+ L D +L I TD G YQC+A N G +
Sbjct: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
Query: 483 VWLL----VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQEDSRI 537
L P I + G V + CSA+G+P P ISW+R + L D R+
Sbjct: 330 EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRV 389
Query: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 597
++ G L IQ V D+G Y+C ATN + + T + P + +V G+
Sbjct: 390 NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449
Query: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 655
CEA G PPP + W +GG ++ + SSG LRI D G Y C+AVN +G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 656 DASAEIQLAVGH--APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713
L V P +P D TVE+G + L C + G P P +TW + DG
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DG------ 562
Query: 714 LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS 773
+ + G L V P D Y C ARN G A ++++ + P +
Sbjct: 563 VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG--SASVSMVLSVNVPDVSRNG 620
Query: 774 APTV 777
P V
Sbjct: 621 DPFV 624
Score = 138 bits (347), Expect = 4e-32
Identities = 96/310 (30%), Positives = 139/310 (44%), Gaps = 12/310 (3%)
Query: 366 ILRASKAEEGTYECTAVSRAG---TGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSC 421
I + ++G Y+C A + AG T + + P V P N V GE+ L C
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 481
G P ++W R R RV L I ++ D G Y C A+N A
Sbjct: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
Query: 482 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541
+ +++V+ PQ ++ + +G V C A G P P I+W++ L D R V +
Sbjct: 424 TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 597
GTL I GVA D G Y CQA N +G+ + V + T P V+ V A + V VG
Sbjct: 484 SGTLRISGVALHDQGQYECQAVNIIGS--QKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
Query: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 655
L C + G P P + W + G+++ + + S G L I DAG Y C A N +G
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
Query: 656 DASAEIQLAV 665
AS + L+V
Sbjct: 602 SASVSMVLSV 611
Score = 102 bits (254), Expect = 2e-21
Identities = 69/259 (26%), Positives = 110/259 (42%), Gaps = 4/259 (1%)
Query: 325 QPLLVSCSVHSALPFRLQLRRGEAR-LGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
+ + + CS P R+ RG+ L + + + I + + G Y C+A +
Sbjct: 357 ESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443
+ A A I+V P V + V G+T C G P + W + L
Sbjct: 417 NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSSQH 501
+ L+ +L ISG+ D G+Y+C A N G + L V R P + S
Sbjct: 477 RRHLV-LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 561
G V++ CS+ G P P I+W+++ + E + H+ +G L I V P DAG Y C
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
Query: 562 ATNEVGTDQETVTLYYTDP 580
A N +G+ ++ L P
Sbjct: 596 ARNTIGSASVSMVLSVNVP 614
Score = 99.4 bits (246), Expect = 2e-20
Identities = 69/215 (32%), Positives = 90/215 (41%), Gaps = 14/215 (6%)
Query: 859 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR-GPHYNVSKEGTLLIA 917
PRI G C A G P P I W + N L+ + N+ +GTL+I
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 918 QPSAQDAGAYVCTATNTVG-FSSQEMRLSVNTKPRIHMNGSRNANV--PLQVTAKAGEEV 974
D G Y C A N G +QE+ L P +R V P GE V
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP------ARPTFVIQPQNTEVLVGESV 359
Query: 975 TLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
TL+C A G PPP ++WT+ R P+ R + PSG L + V GDSG Y C+A+N
Sbjct: 360 TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID 419
Query: 1035 SASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSV 1069
S + VQ PQ P + G +V
Sbjct: 420 SVHATAFIIVQA----LPQFTVTPQDRVVIEGQTV 450
Score = 51.2 bits (121), Expect = 6e-06
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 1/125 (0%)
Query: 948 TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT-NRYGL 1006
T ++ R + P +G V C A+G+P P + W +++ + T +R L
Sbjct: 237 TPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL 296
Query: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSG 1066
L G+L + Q D G Y+C A N AG + V + +P + P + L G
Sbjct: 297 LDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVG 356
Query: 1067 LSVPL 1071
SV L
Sbjct: 357 ESVTL 361
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 188 bits (477), Expect = 3e-47
Identities = 152/531 (28%), Positives = 220/531 (41%), Gaps = 55/531 (10%)
Query: 552 PEDAGNYSCQATNEVGTDQETVTLYYTD--------PPSVSAVNAVVLVAVGEEAVLVCE 603
PED + T +D + +L YT PP + + ++V+ GE A L C+
Sbjct: 31 PEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK 90
Query: 604 ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ------------ERDAGTYTCRAV 651
A G P P + WY+GG + + S ++ +P+ D G Y C A
Sbjct: 91 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 150
Query: 652 NELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT-GRPPPTVTWRRGDG 707
N LG+A +A +++A+ + P DV V +G A++ C+ G P PT++W++ DG
Sbjct: 151 NYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DG 208
Query: 708 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAE-ARLIVTGHA 766
PL + G L D YVC N+ G+ ++E A L V
Sbjct: 209 SPLDDK------DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER- 261
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD 826
P + V C G P+P W KD LP SR+ IR D +L +
Sbjct: 262 -PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRKDDGELPK-SRYEIRDDHTLKIR 318
Query: 827 RALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVP 886
+ G Y+CVA N G L VQ PP + G + C A+G P
Sbjct: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 378
Query: 887 APTITWTKE--TNALTSRGP-----HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
P I W +E N L S P ++VS+ G L I D G Y+C N G
Sbjct: 379 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 438
Query: 940 QEMRLSV-----NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDS 994
+ L V + P + G N V + T L C A GSP P + W KD
Sbjct: 439 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT------FVLSCVATGSPVPTILWRKDG 492
Query: 995 RPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
V +R L +G L++ ++GD+G Y C AS P+G A+ + VQ
Sbjct: 493 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Score = 161 bits (408), Expect = 3e-39
Identities = 175/644 (27%), Positives = 246/644 (38%), Gaps = 66/644 (10%)
Query: 324 HQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
H P LV S+ S P L L A+L + E GN + S ++ +
Sbjct: 5 HVPFLVMISLLSLSPNHLFL----AQLIPDPEDVERGNDHGTPIPTSDNDDNSL------ 54
Query: 384 RAGTGRAKAQIVVTDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------- 434
G +++ D PP++V P+ + VS GE A L+C+ G + W
Sbjct: 55 ----GYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET 110
Query: 435 -----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLL 486
R R+L S L L + D G Y CVA N G AS+ +
Sbjct: 111 DKDDPRSHRMLLPS----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA 166
Query: 487 VREAPQVSIHTSSQHFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGT 544
+ + S + G + C G+P P ISW ++ L + D RI + G
Sbjct: 167 ILR-DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GK 224
Query: 545 LIIQGVAPEDAGNYSCQATNEVGT-DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE 603
L+I DAG Y C TN VG + E L + PS + + V V + A CE
Sbjct: 225 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCE 284
Query: 604 ASGVPPPRVIWYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ 662
A G P P V W + E+ + E L+I D G+YTC A N +G A A
Sbjct: 285 ARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 344
Query: 663 LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSR 721
L V P PRD V LGR+ C ATG P P + WRR Q L + SR
Sbjct: 345 LTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
Query: 722 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVR 778
+G L +V D Y+C+ NV G + +A L VT PP + P +
Sbjct: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 464
Query: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYS 837
+ + V G P+P W KDG + SR +G L + A GRY+
Sbjct: 465 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 524
Query: 838 CVATNTAGSQHRDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTIT 891
C+A+ +G + VQ PPR P + S P +T
Sbjct: 525 CIASTPSGEATWSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVT 570
Query: 892 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
S P+ N T I + + +G+ T V
Sbjct: 571 DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 614
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 186 bits (471), Expect = 2e-46
Identities = 144/495 (29%), Positives = 208/495 (42%), Gaps = 47/495 (9%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
D G Y C A N LG+A +A +++A+ + P DV V +G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
Query: 685 SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
A++ C+ G P PT++W++ DG PL + G L D Y
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
Query: 744 VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
VC N+ G+ ++E A L V P + V C G P+P W
Sbjct: 200 VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
Query: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH 862
KD LP SR+ IR D +L + + G Y+CVA N G L VQ PP
Sbjct: 257 RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
Query: 863 PTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEGTLL 915
+ G + C A+G P P I W +E N L S P ++VS+ G L
Sbjct: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 916 IAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVTAKA 970
I D G Y+C N G + L V + P + G N V + T
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT--- 432
Query: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTAS 1030
L C A GSP P + W KD V +R L +G L++ ++GD+G Y C AS
Sbjct: 433 ---FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
Query: 1031 NPAGSASHRYVLGVQ 1045
P+G A+ + VQ
Sbjct: 490 TPSGEATWSAYIEVQ 504
Score = 158 bits (400), Expect = 3e-38
Identities = 159/570 (27%), Positives = 220/570 (38%), Gaps = 52/570 (9%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 443
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 500
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 501 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 558
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 559 SCQATNEVGT-DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 617
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 618 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPR 676
E+ + E L+I D G+YTC A N +G A A L V P PR
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
Query: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFESV 735
D V LGR+ C ATG P P + WRR Q L + SR +G L +V
Sbjct: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
Query: 736 APEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPCIVL 792
D Y+C+ NV G + +A L VT PP + P + + + V
Sbjct: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
Query: 793 AGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851
G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
Query: 852 ELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
+ VQ PPR P + S P +T S P+
Sbjct: 500 YIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 545
Query: 906 YNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
N T I + + +G+ T V
Sbjct: 546 LNSGATPTSYIIEAFSHASGSSWQTVAENV 575
Score = 144 bits (364), Expect = 4e-34
Identities = 121/422 (28%), Positives = 185/422 (43%), Gaps = 30/422 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 484 -WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
TL I+ V D G+Y+C A N VG + + TL +PP +VA+G C
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQC 333
Query: 603 EASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCRAVN 652
EA+G P P + W R G + +L P+ SS +G L I Q D G Y C+ +N
Sbjct: 334 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
Query: 653 ELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD 706
G + L V P + + P + TV + + +L+C ATG P PT+ WR+ D
Sbjct: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK-D 452
Query: 707 GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 766
G L + + SR +Q ++GVL D Y C A G+ A + V
Sbjct: 453 GV-----LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 507
Query: 767 PP 768
P
Sbjct: 508 VP 509
Score = 71.6 bits (174), Expect = 4e-12
Identities = 62/240 (25%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 403
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V +PP +
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
Query: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLADLS 454
V + V+ G T C G + W R+ P S+ R V+Q DL+
Sbjct: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQGVEV 508
I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 --ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
Query: 509 KVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+ G
Sbjct: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 185 bits (469), Expect = 3e-46
Identities = 129/417 (30%), Positives = 180/417 (43%), Gaps = 28/417 (6%)
Query: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
P++ E P D+ V G A L CRA GRP P + W + + +R R R P SG
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-RAHRLLLP-SG 121
Query: 729 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 783
LFF + A D+ Y C ARN G + + S V V G+
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
Query: 784 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 843
P L C+ G P P W KDG L G L + L+ AG Y CVA+N
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241
Query: 844 AGS-QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
AG + E++V P + + P + C G P P + W KE L +
Sbjct: 242 AGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT- 300
Query: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Y + + +L I SA+D G Y C A N+VG + LSV+ P++
Sbjct: 301 -GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL-------VTQ 352
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD--------SRPVPPITNRYGLLPSGSLRL 1014
P A GE V CE KG+PPP + W K+ S+ + P T R+ + P G L +
Sbjct: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQP-TGRFSVSPRGQLNI 411
Query: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT--SWQPQSLPVPHHPACLSGLSV 1069
VQ GD+G+Y C A + AGS + +L ++G + P L P + + G SV
Sbjct: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSV 468
Score = 184 bits (468), Expect = 3e-46
Identities = 145/477 (30%), Positives = 207/477 (43%), Gaps = 47/477 (9%)
Query: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ---------- 639
+LV+ GE A L C A G P P + WY+ G + E + +L +P+
Sbjct: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGR 132
Query: 640 --ERDAGTYTCRAVNELGDAS---AEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RAT 693
D G YTC A N LG A+ A +++AV + P +V V +G A+L C
Sbjct: 133 RARPDEGVYTCVARNYLGAAASRNASLEVAVLR-DDFRQSPGNVVVAVGEPAVLECVPPR 191
Query: 694 GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
G P P+V+WR+ G RL G + + G L D YVC A N+ G+
Sbjct: 192 GHPEPSVSWRKD-----GARLKEEEGRITIR--GGKLMMSHTLKSDAGMYVCVASNMAGE 244
Query: 754 VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS 813
++ A ++ P + V VL PV+ C V G P P W K+ LP G
Sbjct: 245 RESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEV-KGDPPPRLRWRKEDGELPTG- 301
Query: 814 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEG 873
R+ IR+D SL + E G Y+CVA N+ G L V VPP++ + G
Sbjct: 302 RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPG 361
Query: 874 VPASLPCVASGVPAPTITWTKE--------TNALTSRGPHYNVSKEGTLLIAQPSAQDAG 925
+ C G P P I W KE + +L G ++VS G L I DAG
Sbjct: 362 ESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG-RFSVSPRGQLNITAVQRGDAG 420
Query: 926 AYVCTATNTVGFSSQEMRL-----SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
YVC A + G + L S++ P + + G N + L G V L C
Sbjct: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL------GSSVWLPCRV 474
Query: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
G+P P V W KD + + ++ + +G+L +A VQ D G Y C A + G A+
Sbjct: 475 TGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
Score = 162 bits (411), Expect = 1e-39
Identities = 123/407 (30%), Positives = 182/407 (44%), Gaps = 30/407 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC-RV 423
R ++ +EG Y C A + A + A ++ V + P NV V+ GE AVL C
Sbjct: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG-NVVVAVGEPAVLECVPP 190
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-AS 482
G +++W +D L GR+ + L +S + +D G Y CVASN G A+
Sbjct: 191 RGHPEPSVSWRKDGARLKEEEGRIT-IRGGKLMMSHTLKSDAGMYVCVASNMAGERESAA 249
Query: 483 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
++V E P +Q V C G P P + W +E L R + +
Sbjct: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRYEIRSD 308
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
+L I V+ ED G Y+C A N VG + + +L PP + + A GE C
Sbjct: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
Query: 603 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 652
E G PPP + W + G +++L P S G+L I A Q DAG Y C+AV+
Sbjct: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
Query: 653 ELGDASAEIQLAV------GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD 706
G A+ L + G P + + P + T+ LG S L CR TG P P+V W++ D
Sbjct: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK-D 487
Query: 707 GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
GQ L G + + +G L+ +V D Y C A++ G+
Sbjct: 488 GQWL-----QGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
Score = 156 bits (394), Expect = 1e-37
Identities = 146/485 (30%), Positives = 203/485 (41%), Gaps = 54/485 (11%)
Query: 398 DPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 456
D P++V P ++ VS GE A L CR G N+ W ++ +T R A L
Sbjct: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNG--ARVATVREDPRAHRLLL 118
Query: 457 ISGII-----------PTDGGRYQCVASNANGVT---RASVWLLV-----REAPQVSIHT 497
SG + D G Y CVA N G AS+ + V R++P
Sbjct: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP------ 172
Query: 498 SSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAG 556
+ + G + C G+P P +SW ++ L+E+ G L++ DAG
Sbjct: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
Query: 557 NYSCQATNEVG-TDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVI 613
Y C A+N G + + + PS VN VVL +CE G PPPR+
Sbjct: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVL--ADAPVTFLCEVKGDPPPRLR 290
Query: 614 WYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 672
W + E+ E S L I D GTYTC A N +G A A L+V PQL
Sbjct: 291 WRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
Query: 673 ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS----- 727
P+D G S C G PPP + W++ Q L S+S QP
Sbjct: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLF------PSQSLQPTGRFSVS 404
Query: 728 --GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLE 781
G L +V D YVC+A +V G + A+A L + G + PP I ++
Sbjct: 405 PRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
Query: 782 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVA 840
G V LPC V G P P W KDG+ L + A+G+L++ + G YSCVA
Sbjct: 465 GSSVWLPCRV-TGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVA 523
Query: 841 TNTAG 845
++ G
Sbjct: 524 KSSTG 528
Score = 99.0 bits (245), Expect = 2e-20
Identities = 77/257 (29%), Positives = 111/257 (43%), Gaps = 17/257 (6%)
Query: 326 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA 385
P+ C V P RL+ R+ + L R+ S +S W I S +EGTY C A +
Sbjct: 274 PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSV 332
Query: 386 GTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWR---VLP 441
G A + V PPQLV P + +PGE+ C G P + W ++ + P
Sbjct: 333 GRAEASGSLSV-HVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
Query: 442 AS----TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA------P 491
+ TGR + L I+ + D G Y C A + G A L ++ A P
Sbjct: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPP 451
Query: 492 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGV 550
+ ++Q G V + C +G P P + W ++ Q LQ +D + A GTL I V
Sbjct: 452 VILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANV 511
Query: 551 APEDAGNYSCQATNEVG 567
D G YSC A + G
Sbjct: 512 QEMDMGFYSCVAKSSTG 528
Score = 62.4 bits (150), Expect = 3e-09
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP-----PPQLVPAP-NV 409
F S I + + G Y C AVS AG+ AKA + + PP ++ P N
Sbjct: 401 FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ 460
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
T+ G + L CRV G ++ W +D + L + +A+ +L I+ + D G Y
Sbjct: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYS 520
Query: 470 CVASNANGVTRASVWLLVRE 489
CVA ++ G S WL +RE
Sbjct: 521 CVAKSSTGEATWSGWLKMRE 540
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 182 bits (463), Expect = 1e-45
Identities = 145/498 (29%), Positives = 209/498 (41%), Gaps = 50/498 (10%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
D G Y C A N LG+A +A +++A+ + P DV V +G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
Query: 685 SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
A++ C+ G P PT++W++ DG PL + G L D Y
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
Query: 744 VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
VC N+ G+ ++E A L V P + V C G P+P W
Sbjct: 200 VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
Query: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PP 859
KD LP SR+ IR D +L + + G Y+CVA N G L VQV PP
Sbjct: 257 RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEG 912
+ G + C A+G P P I W +E N L S P ++VS+ G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVT 967
L I D G Y+C N G + L V + P + G N V + T
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
L C A GSP P + W KD V +R L +G L++ ++GD+G Y C
Sbjct: 436 ------FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489
Query: 1028 TASNPAGSASHRYVLGVQ 1045
AS P+G A+ + VQ
Sbjct: 490 IASTPSGEATWSAYIEVQ 507
Score = 154 bits (388), Expect = 6e-37
Identities = 159/573 (27%), Positives = 220/573 (38%), Gaps = 55/573 (9%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 443
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 500
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 501 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 558
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 559 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 617
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 618 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTE 673
E+ + E L+I D G+YTC A N +G A A L V P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFF 732
PRD V LGR+ C ATG P P + WRR Q L + SR +G L
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPC 789
+V D Y+C+ NV G + +A L VT PP + P + + +
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 790 IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 440 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Query: 849 RDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
+ VQ PPR P + S P +T S
Sbjct: 500 WSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Query: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
P+ N T I + + +G+ T V
Sbjct: 546 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 578
Score = 140 bits (352), Expect = 1e-32
Identities = 121/425 (28%), Positives = 186/425 (43%), Gaps = 33/425 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 484 -WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 599
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 600 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 649
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 650 AVNELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTWR 703
+N G + L V P + + P + TV + + +L+C ATG P PT+ WR
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
+ DG L + + SR +Q ++GVL D Y C A G+ A + V
Sbjct: 454 K-DGV-----LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 764 GHAPP 768
P
Sbjct: 508 EFGVP 512
Score = 67.0 bits (162), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 400
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 401 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 451
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 505
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 506 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 564
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 565 EVG 567
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 409
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 470 CVASNANGVTRASVWLLVRE 489
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 182 bits (463), Expect = 1e-45
Identities = 145/498 (29%), Positives = 209/498 (41%), Gaps = 50/498 (10%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
D G Y C A N LG+A +A +++A+ + P DV V +G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
Query: 685 SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
A++ C+ G P PT++W++ DG PL + G L D Y
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
Query: 744 VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
VC N+ G+ ++E A L V P + V C G P+P W
Sbjct: 200 VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
Query: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PP 859
KD LP SR+ IR D +L + + G Y+CVA N G L VQV PP
Sbjct: 257 RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEG 912
+ G + C A+G P P I W +E N L S P ++VS+ G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVT 967
L I D G Y+C N G + L V + P + G N V + T
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
L C A GSP P + W KD V +R L +G L++ ++GD+G Y C
Sbjct: 436 ------FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489
Query: 1028 TASNPAGSASHRYVLGVQ 1045
AS P+G A+ + VQ
Sbjct: 490 IASTPSGEATWSAYIEVQ 507
Score = 154 bits (388), Expect = 6e-37
Identities = 159/573 (27%), Positives = 220/573 (38%), Gaps = 55/573 (9%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 443
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 500
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 501 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 558
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 559 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 617
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 618 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTE 673
E+ + E L+I D G+YTC A N +G A A L V P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFF 732
PRD V LGR+ C ATG P P + WRR Q L + SR +G L
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPC 789
+V D Y+C+ NV G + +A L VT PP + P + + +
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 790 IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 440 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Query: 849 RDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
+ VQ PPR P + S P +T S
Sbjct: 500 WSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Query: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
P+ N T I + + +G+ T V
Sbjct: 546 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 578
Score = 140 bits (352), Expect = 1e-32
Identities = 121/425 (28%), Positives = 186/425 (43%), Gaps = 33/425 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 484 -WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 599
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 600 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 649
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 650 AVNELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTWR 703
+N G + L V P + + P + TV + + +L+C ATG P PT+ WR
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
+ DG L + + SR +Q ++GVL D Y C A G+ A + V
Sbjct: 454 K-DGV-----LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 764 GHAPP 768
P
Sbjct: 508 EFGVP 512
Score = 67.0 bits (162), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 400
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 401 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 451
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 505
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 506 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 564
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 565 EVG 567
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 409
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 470 CVASNANGVTRASVWLLVRE 489
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 182 bits (463), Expect = 1e-45
Identities = 145/498 (29%), Positives = 209/498 (41%), Gaps = 50/498 (10%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
D G Y C A N LG+A +A +++A+ + P DV V +G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
Query: 685 SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
A++ C+ G P PT++W++ DG PL + G L D Y
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
Query: 744 VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
VC N+ G+ ++E A L V P + V C G P+P W
Sbjct: 200 VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
Query: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PP 859
KD LP SR+ IR D +L + + G Y+CVA N G L VQV PP
Sbjct: 257 RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEG 912
+ G + C A+G P P I W +E N L S P ++VS+ G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVT 967
L I D G Y+C N G + L V + P + G N V + T
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
L C A GSP P + W KD V +R L +G L++ ++GD+G Y C
Sbjct: 436 ------FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489
Query: 1028 TASNPAGSASHRYVLGVQ 1045
AS P+G A+ + VQ
Sbjct: 490 IASTPSGEATWSAYIEVQ 507
Score = 154 bits (388), Expect = 6e-37
Identities = 159/573 (27%), Positives = 220/573 (38%), Gaps = 55/573 (9%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 443
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 500
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 501 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 558
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 559 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 617
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 618 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTE 673
E+ + E L+I D G+YTC A N +G A A L V P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFF 732
PRD V LGR+ C ATG P P + WRR Q L + SR +G L
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPC 789
+V D Y+C+ NV G + +A L VT PP + P + + +
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 790 IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 440 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Query: 849 RDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
+ VQ PPR P + S P +T S
Sbjct: 500 WSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Query: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
P+ N T I + + +G+ T V
Sbjct: 546 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 578
Score = 140 bits (352), Expect = 1e-32
Identities = 121/425 (28%), Positives = 186/425 (43%), Gaps = 33/425 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 484 -WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 599
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 600 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 649
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 650 AVNELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTWR 703
+N G + L V P + + P + TV + + +L+C ATG P PT+ WR
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
+ DG L + + SR +Q ++GVL D Y C A G+ A + V
Sbjct: 454 K-DGV-----LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 764 GHAPP 768
P
Sbjct: 508 EFGVP 512
Score = 67.0 bits (162), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 400
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 401 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 451
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 505
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 506 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 564
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 565 EVG 567
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 409
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 470 CVASNANGVTRASVWLLVRE 489
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 182 bits (463), Expect = 1e-45
Identities = 145/498 (29%), Positives = 209/498 (41%), Gaps = 50/498 (10%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
D G Y C A N LG+A +A +++A+ + P DV V +G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
Query: 685 SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
A++ C+ G P PT++W++ DG PL + G L D Y
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
Query: 744 VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 802
VC N+ G+ ++E A L V P + V C G P+P W
Sbjct: 200 VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
Query: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PP 859
KD LP SR+ IR D +L + + G Y+CVA N G L VQV PP
Sbjct: 257 RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEG 912
+ G + C A+G P P I W +E N L S P ++VS+ G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVT 967
L I D G Y+C N G + L V + P + G N V + T
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
L C A GSP P + W KD V +R L +G L++ ++GD+G Y C
Sbjct: 436 ------FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489
Query: 1028 TASNPAGSASHRYVLGVQ 1045
AS P+G A+ + VQ
Sbjct: 490 IASTPSGEATWSAYIEVQ 507
Score = 154 bits (388), Expect = 6e-37
Identities = 159/573 (27%), Positives = 220/573 (38%), Gaps = 55/573 (9%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 443
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 500
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 501 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 558
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 559 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 617
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 618 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTE 673
E+ + E L+I D G+YTC A N +G A A L V P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFF 732
PRD V LGR+ C ATG P P + WRR Q L + SR +G L
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPC 789
+V D Y+C+ NV G + +A L VT PP + P + + +
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 790 IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 848
V G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 440 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
Query: 849 RDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
+ VQ PPR P + S P +T S
Sbjct: 500 WSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Query: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
P+ N T I + + +G+ T V
Sbjct: 546 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 578
Score = 140 bits (352), Expect = 1e-32
Identities = 121/425 (28%), Positives = 186/425 (43%), Gaps = 33/425 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 483
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 484 -WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 599
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 600 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 649
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 650 AVNELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTWR 703
+N G + L V P + + P + TV + + +L+C ATG P PT+ WR
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 704 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
+ DG L + + SR +Q ++GVL D Y C A G+ A + V
Sbjct: 454 K-DGV-----LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 764 GHAPP 768
P
Sbjct: 508 EFGVP 512
Score = 67.0 bits (162), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 400
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 401 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 451
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 505
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 506 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 564
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 565 EVG 567
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 409
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 470 CVASNANGVTRASVWLLVRE 489
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 181 bits (459), Expect = 4e-45
Identities = 137/499 (27%), Positives = 214/499 (42%), Gaps = 57/499 (11%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + V+V+ GE L C+A G P P + WY+ G + + S ++ +P+
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
+ D G+Y C A N LG+A +A +++A+ + P DV V G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR-DDFRQNPTDVVVAAGE 164
Query: 685 SALLACRAT-GRPPPTVTWRRGD------GQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
A+L C+ G P PT+ W++ + + +R G S +R+ D+G+
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM-------- 216
Query: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Y C N+ G+ ++ + P + V VLE + V C V G P
Sbjct: 217 -----YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRCQV-QGDPQ 269
Query: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 857
P W KD LP G R+ I+ D +L + + + G Y C+A N G L V+
Sbjct: 270 PTVRWKKDDADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 328
Query: 858 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGPHY-----NVSK 910
PP+ I +G + PC G P P + W KE N L P +VS
Sbjct: 329 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 388
Query: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQ 965
G L I DAG Y+C A G + +L V + P I + G N + +
Sbjct: 389 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 448
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
TA L C+A G P P+++W K+ P R + G+L++ +++ D+G Y
Sbjct: 449 GTA------LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY 502
Query: 1026 ECTASNPAGSASHRYVLGV 1044
C A++ +G S VL V
Sbjct: 503 TCVATSSSGETSWSAVLDV 521
Score = 155 bits (391), Expect = 3e-37
Identities = 141/475 (29%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ----LAD 452
D PP++V P+ V VS GE L+C+ G + W +D + L
Sbjct: 44 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 453 LSLEISGII-----PTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHFSQG 505
SL I+ D G Y CVA N G V+R + + + + + G
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 506 VEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
+ C G+P P I W ++ + + + RI + G L+I DAG Y+C T
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGT 222
Query: 564 NEVGT-DQETVTLYYTDPPSV--SAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRGGL 619
N VG D + L + P+ +N VVL EEAV C+ G P P V W +
Sbjct: 223 NMVGERDSDPAELTVFERPTFLRRPINQVVLE---EEAVEFRCQVQGDPQPTVRWKKDDA 279
Query: 620 EMILAPEGSSSGK----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 675
++ P G K LRI D GTY C A N +G A L V PQ P
Sbjct: 280 DL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 336
Query: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-RLGAGRGSRSRQPDSGVLFFES 734
RD V GR+ C G P P V W++ Q L SR +G L +
Sbjct: 337 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 396
Query: 735 VAPEDQAPYVCEARNVFGKVQAEARLIVTG---HAPPQIASSAPTVRVLEGQPVSLPCIV 791
+ D Y+C+A V G + A+A+L VT PP I P + L +L
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 456
Query: 792 LAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
G PLP WLK+G P R +I+ G+L + G Y+CVAT+++G
Sbjct: 457 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 511
Score = 137 bits (346), Expect = 5e-32
Identities = 118/418 (28%), Positives = 174/418 (41%), Gaps = 32/418 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R SK +EG+Y C A + A + A ++ + + P +V V+ GE A+L C+
Sbjct: 115 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-DVVVAAGEPAILECQPP 173
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS- 482
G + W +D + R++ + L IS +D G Y CV +N G +
Sbjct: 174 RGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP 232
Query: 483 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P +Q + V+ C G P P + W ++ L R +
Sbjct: 233 AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDD 291
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
TL I+ D G Y C A N VG + + TL PP +VA G C
Sbjct: 292 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPC 351
Query: 603 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 652
E G P P V W + G + +L P S +G L I Q DAG Y C+A+
Sbjct: 352 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 411
Query: 653 ELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRG 705
G A+ QL V P + + P + T+ + +ALL C+ATG P P ++W + G
Sbjct: 412 VAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG 471
Query: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
P GR R+ + G L +++ D Y C A + G+ A L VT
Sbjct: 472 FTFP-------GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 522
Score = 125 bits (314), Expect = 2e-28
Identities = 100/353 (28%), Positives = 144/353 (40%), Gaps = 21/353 (5%)
Query: 325 QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
+P ++ C P + ++ + R+ ++ I K++ G Y C +
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 223
Query: 384 RAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 442
G + A++ V + P L N V E C+V G+ + W +D LP
Sbjct: 224 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 282
Query: 443 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 502
GR D +L I + TD G Y C+A N G AS L VR PQ + Q
Sbjct: 283 -RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 341
Query: 503 SQGVEVKVSCSASGYPTPHISWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPED 554
+QG V C G P P + W +E +Q Q +SR V G L I + D
Sbjct: 342 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 401
Query: 555 AGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVP 608
AG Y CQA G+ L TD PP + A +AV A+L C+A+G P
Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 461
Query: 609 PPRVIWYRGGLEMI-LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDAS 658
P + W + G P + G L+I + D GTYTC A + G+ S
Sbjct: 462 LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 514
Score = 105 bits (263), Expect = 2e-22
Identities = 91/318 (28%), Positives = 127/318 (39%), Gaps = 31/318 (9%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP-----PGSRHSIRADG 821
PP+I V V +G+P +L C GRP P W KDG + P S + G
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 822 SLHLDRAL-----QEHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEG 873
SL R + + G Y CVA N G S++ +E+ + + T + G
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAG 163
Query: 874 VPASLPCVAS-GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 932
PA L C G P PTI W K+ + + ++ + G L+I+ DAG Y C T
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTCVGT 222
Query: 933 NTVGF-SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT 991
N VG S L+V +P P+ E V C+ +G P P V W
Sbjct: 223 NMVGERDSDPAELTVFERPTFLRR-------PINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 992 KDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQ 1051
KD +P RY + +LR+ + D G Y C A N G L V+
Sbjct: 276 KDDADLP--RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA----P 329
Query: 1052 PQSLPVPHHPACLSGLSV 1069
PQ + P G +V
Sbjct: 330 PQFVVRPRDQIVAQGRTV 347
Score = 80.9 bits (198), Expect = 7e-15
Identities = 75/292 (25%), Positives = 116/292 (39%), Gaps = 29/292 (9%)
Query: 322 YLHQPLLVSCSVHSALPFRLQL----------RRGEARLGEERHFQESGNSSWEILRASK 371
+L +P+ A+ FR Q+ ++ +A L R + + + I +
Sbjct: 243 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDDYTLRIKKTMS 301
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 431
+EGTY C A +R G A A + V PP +V + V+ G T C G +
Sbjct: 302 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 361
Query: 432 TWVRDWR---------VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 482
W ++ P S V+ DL+ I+ I +D G Y C A G A
Sbjct: 362 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT--ITNIQRSDAGYYICQALTVAGSILAK 419
Query: 483 VWLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDS 535
L V R P + ++Q + + C A+G P P ISW +E D
Sbjct: 420 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 479
Query: 536 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 587
R + QGTL I+ + D G Y+C AT+ G + L T+ + + N
Sbjct: 480 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 531
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 181 bits (459), Expect = 4e-45
Identities = 137/499 (27%), Positives = 214/499 (42%), Gaps = 57/499 (11%)
Query: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 639
PP + + V+V+ GE L C+A G P P + WY+ G + + S ++ +P+
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 640 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 684
+ D G+Y C A N LG+A +A +++A+ + P DV V G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR-DDFRQNPTDVVVAAGE 148
Query: 685 SALLACRAT-GRPPPTVTWRRGD------GQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
A+L C+ G P PT+ W++ + + +R G S +R+ D+G+
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM-------- 200
Query: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Y C N+ G+ ++ + P + V VLE + V C V G P
Sbjct: 201 -----YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRCQV-QGDPQ 253
Query: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 857
P W KD LP G R+ I+ D +L + + + G Y C+A N G L V+
Sbjct: 254 PTVRWKKDDADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 312
Query: 858 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGPHY-----NVSK 910
PP+ I +G + PC G P P + W KE N L P +VS
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 372
Query: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQ 965
G L I DAG Y+C A G + +L V + P I + G N + +
Sbjct: 373 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
Query: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
TA L C+A G P P+++W K+ P R + G+L++ +++ D+G Y
Sbjct: 433 GTA------LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY 486
Query: 1026 ECTASNPAGSASHRYVLGV 1044
C A++ +G S VL V
Sbjct: 487 TCVATSSSGETSWSAVLDV 505
Score = 155 bits (391), Expect = 3e-37
Identities = 141/475 (29%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 398 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ----LAD 452
D PP++V P+ V VS GE L+C+ G + W +D + L
Sbjct: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 453 LSLEISGII-----PTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHFSQG 505
SL I+ D G Y CVA N G V+R + + + + + G
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 506 VEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
+ C G+P P I W ++ + + + RI + G L+I DAG Y+C T
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGT 206
Query: 564 NEVGT-DQETVTLYYTDPPSV--SAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRGGL 619
N VG D + L + P+ +N VVL EEAV C+ G P P V W +
Sbjct: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLE---EEAVEFRCQVQGDPQPTVRWKKDDA 263
Query: 620 EMILAPEGSSSGK----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 675
++ P G K LRI D GTY C A N +G A L V PQ P
Sbjct: 264 DL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
Query: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-RLGAGRGSRSRQPDSGVLFFES 734
RD V GR+ C G P P V W++ Q L SR +G L +
Sbjct: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
Query: 735 VAPEDQAPYVCEARNVFGKVQAEARLIVTG---HAPPQIASSAPTVRVLEGQPVSLPCIV 791
+ D Y+C+A V G + A+A+L VT PP I P + L +L
Sbjct: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
Query: 792 LAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
G PLP WLK+G P R +I+ G+L + G Y+CVAT+++G
Sbjct: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
Score = 137 bits (346), Expect = 5e-32
Identities = 118/418 (28%), Positives = 174/418 (41%), Gaps = 32/418 (7%)
Query: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 423
R SK +EG+Y C A + A + A ++ + + P +V V+ GE A+L C+
Sbjct: 99 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-DVVVAAGEPAILECQPP 157
Query: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS- 482
G + W +D + R++ + L IS +D G Y CV +N G +
Sbjct: 158 RGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP 216
Query: 483 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
L V E P +Q + V+ C G P P + W ++ L R +
Sbjct: 217 AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDD 275
Query: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
TL I+ D G Y C A N VG + + TL PP +VA G C
Sbjct: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPC 335
Query: 603 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 652
E G P P V W + G + +L P S +G L I Q DAG Y C+A+
Sbjct: 336 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 395
Query: 653 ELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRG 705
G A+ QL V P + + P + T+ + +ALL C+ATG P P ++W + G
Sbjct: 396 VAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG 455
Query: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763
P GR R+ + G L +++ D Y C A + G+ A L VT
Sbjct: 456 FTFP-------GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
Score = 125 bits (314), Expect = 2e-28
Identities = 100/353 (28%), Positives = 144/353 (40%), Gaps = 21/353 (5%)
Query: 325 QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
+P ++ C P + ++ + R+ ++ I K++ G Y C +
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 207
Query: 384 RAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 442
G + A++ V + P L N V E C+V G+ + W +D LP
Sbjct: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 266
Query: 443 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 502
GR D +L I + TD G Y C+A N G AS L VR PQ + Q
Sbjct: 267 -RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
Query: 503 SQGVEVKVSCSASGYPTPHISWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPED 554
+QG V C G P P + W +E +Q Q +SR V G L I + D
Sbjct: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 385
Query: 555 AGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVP 608
AG Y CQA G+ L TD PP + A +AV A+L C+A+G P
Sbjct: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
Query: 609 PPRVIWYRGGLEMI-LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDAS 658
P + W + G P + G L+I + D GTYTC A + G+ S
Sbjct: 446 LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
Score = 105 bits (263), Expect = 2e-22
Identities = 91/318 (28%), Positives = 127/318 (39%), Gaps = 31/318 (9%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP-----PGSRHSIRADG 821
PP+I V V +G+P +L C GRP P W KDG + P S + G
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
Query: 822 SLHLDRAL-----QEHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEG 873
SL R + + G Y CVA N G S++ +E+ + + T + G
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAG 147
Query: 874 VPASLPCVAS-GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 932
PA L C G P PTI W K+ + + ++ + G L+I+ DAG Y C T
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTCVGT 206
Query: 933 NTVGF-SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT 991
N VG S L+V +P P+ E V C+ +G P P V W
Sbjct: 207 NMVGERDSDPAELTVFERPTFLRR-------PINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 992 KDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQ 1051
KD +P RY + +LR+ + D G Y C A N G L V+
Sbjct: 260 KDDADLP--RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA----P 313
Query: 1052 PQSLPVPHHPACLSGLSV 1069
PQ + P G +V
Sbjct: 314 PQFVVRPRDQIVAQGRTV 331
Score = 80.9 bits (198), Expect = 7e-15
Identities = 75/292 (25%), Positives = 116/292 (39%), Gaps = 29/292 (9%)
Query: 322 YLHQPLLVSCSVHSALPFRLQL----------RRGEARLGEERHFQESGNSSWEILRASK 371
+L +P+ A+ FR Q+ ++ +A L R + + + I +
Sbjct: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDDYTLRIKKTMS 285
Query: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 431
+EGTY C A +R G A A + V PP +V + V+ G T C G +
Sbjct: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345
Query: 432 TWVRDWR---------VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 482
W ++ P S V+ DL+ I+ I +D G Y C A G A
Sbjct: 346 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT--ITNIQRSDAGYYICQALTVAGSILAK 403
Query: 483 VWLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDS 535
L V R P + ++Q + + C A+G P P ISW +E D
Sbjct: 404 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 463
Query: 536 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 587
R + QGTL I+ + D G Y+C AT+ G + L T+ + + N
Sbjct: 464 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 515
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 179 bits (453), Expect = 2e-44
Identities = 160/577 (27%), Positives = 240/577 (41%), Gaps = 67/577 (11%)
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE----ISGIIPTDGGRYQ 469
G VL+C G P W+ + R +L SLE I+ + T G Y+
Sbjct: 41 GNRLVLTCMAEGSWPLEFKWLHNNR----------ELTKFSLEYRYMITSLDRTHAGFYR 90
Query: 470 CVASNANGVTRASVWLLVREAPQVSI-----------HTSSQHFSQGVEVKVSCSASGYP 518
C+ N G L++ +V + H S H V ++ AS +P
Sbjct: 91 CIVRNRMGA-------LLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAV-IRAPRIAS-FP 141
Query: 519 TPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-----TV 573
P ++W R+ + + SRI + + TL+I DAG Y QA N+ D + T+
Sbjct: 142 QPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITL 201
Query: 574 TLYYTDPPSVSAVNAVVL-------VAVGEEAVLVCEASGVP--PPRVIWYRGGLEMILA 624
T+ P+ +++ VA E L C A+ P +IW + G+ ++
Sbjct: 202 TVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV-LLSG 260
Query: 625 PEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ---LAVGHAPQLTELP-RDVTV 680
+ +L IP DAG Y C AV + ++ L+V PQ + P R +T
Sbjct: 261 GISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITA 320
Query: 681 ELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 740
E+ + + C+A G PPP++TW + + + +R RQ + G L + P+D
Sbjct: 321 EMEKVVDIPCQAKGVPPPSITWYKD-----AAVVEVEKLTRFRQRNDGGLQISGLVPDDT 375
Query: 741 APYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER 800
+ C ARN G+VQ L VT A P I V++G V L C +G P P
Sbjct: 376 GMFQCFARNAAGEVQTSTYLAVTSIA-PNITRGPLDSTVIDGMSVVLAC-ETSGAPRPAI 433
Query: 801 HWLKDGRPLPPGS----RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856
W K R L GS R + GSL + AG Y+C+ATN+ G +LVV
Sbjct: 434 TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
Query: 857 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTI--TWTKETNAL-TSRGPHYNVSKEGT 913
RI +G AS+ C + P TI W K+ L T P + + G+
Sbjct: 494 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS 553
Query: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
L I+Q + D G Y C + G S+ L V P
Sbjct: 554 LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLP 590
Score = 127 bits (319), Expect = 6e-29
Identities = 129/448 (28%), Positives = 185/448 (41%), Gaps = 50/448 (11%)
Query: 366 ILRASKAEEGTYECTAVS-RAGTGRAKAQIVVT--------DP--PPQLVPAPNVTVSPG 414
IL + G Y AV+ + G + I +T DP P ++P N +V G
Sbjct: 170 ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAG 229
Query: 415 ETAVLSCRVLGEAPY---NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 471
+ V V P ++ W +D +L +G ++ + L I +D G Y+C
Sbjct: 230 TSEVTLECVANARPLIKLHIIWKKDGVLL---SGGISD-HNRRLTIPNPTGSDAGYYECE 285
Query: 472 A----SNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--VKVSCSASGYPTPHISWS 525
A S+ V R + +L V E PQ + +H + +E V + C A G P P I+W
Sbjct: 286 AVLRSSSVPSVVRGA-YLSVLEPPQF-VKEPERHITAEMEKVVDIPCQAKGVPPPSITWY 343
Query: 526 RESQALQED--SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD-PPS 582
+++ ++ + +R G L I G+ P+D G + C A N G Q + L T P+
Sbjct: 344 KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN 403
Query: 583 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---------SSGKL 633
++ V G VL CE SG P P + W +G E ILA GS SG L
Sbjct: 404 ITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG--ERILA-SGSVQLPRFTPLESGSL 460
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 693
I DAGTYTC A N G A L V ++T+ P+D +V G A + C T
Sbjct: 461 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVT 520
Query: 694 GRPPPTV--TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
P T+ W + G LG R R +G L D Y C +
Sbjct: 521 HDPRVTIRYIWEKD-----GATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG 575
Query: 752 GKVQAEARLIV--TGHAPPQIASSAPTV 777
G A L V HAP ++ TV
Sbjct: 576 GNDSRSAHLRVRQLPHAPEHPVATLSTV 603
Score = 122 bits (306), Expect = 2e-27
Identities = 155/592 (26%), Positives = 224/592 (37%), Gaps = 69/592 (11%)
Query: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
+G + ++C A G W ++ L + S + +I + AG Y C
Sbjct: 40 EGNRLVLTCMAEGSWPLEFKWLHNNRELTKFS-----LEYRYMITSLDRTHAGFYRCIVR 94
Query: 564 NEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVIWYRGGL 619
N +G Q V + Y S V+ GE AV+ + P P+V W+R G
Sbjct: 95 NRMGALLQRQTEVQVAYMG--SFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152
Query: 620 EMILAPEGSS-----SGKLRIPAAQERDAGTYTCRAVNEL-GD--ASAEIQLAVGH---- 667
++ P S L I + DAG Y +AVN+ GD S I L V +
Sbjct: 153 KI---PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGP 209
Query: 668 ----APQLTELPRDVTVELGRSAL-LACRATGRP--PPTVTWRRGDGQPLGLRLGAGRGS 720
AP + P++ +V G S + L C A RP + W++ G+ L G
Sbjct: 210 ADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKD-----GVLLSGGISD 264
Query: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR-LIVTGHAPPQIASSAPTVRV 779
+R+ L + D Y CEA V + R ++ PPQ
Sbjct: 265 HNRR-----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHIT 319
Query: 780 LEGQPV-SLPCIVLAGRPLPERHWLKDGRPLPPG--SRHSIRADGSLHLDRALQEHAGRY 836
E + V +PC G P P W KD + +R R DG L + + + G +
Sbjct: 320 AEMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMF 378
Query: 837 SCVATNTAGSQHRDVELVV-QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE 895
C A N AG L V + P I +G+ L C SG P P ITW K
Sbjct: 379 QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG 438
Query: 896 TNALTSRG---PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRI 952
L S P + + G+LLI+ DAG Y C ATN+ G L V + RI
Sbjct: 439 ERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI 498
Query: 953 HMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV--TWTKDSRPVPPITN-RYGLLPS 1009
P + G + ++ C P + W KD + ++ R L +
Sbjct: 499 -------TKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN 551
Query: 1010 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHP 1061
GSL ++Q GD G Y C + G+ S L V+ Q P HP
Sbjct: 552 GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVR-------QLPHAPEHP 596
Score = 96.3 bits (238), Expect = 2e-19
Identities = 100/359 (27%), Positives = 146/359 (40%), Gaps = 38/359 (10%)
Query: 743 YVCEARNVFGKV---QAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPE 799
Y C RN G + Q E ++ G V G+ + +A P P+
Sbjct: 89 YRCIVRNRMGALLQRQTEVQVAYMG----SFEEGEKHQSVSHGEAAVIRAPRIASFPQPQ 144
Query: 800 RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD-------VE 852
W +DGR +PP SR +I + +L + + AGRY A N ++ VE
Sbjct: 145 VTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVE 204
Query: 853 LVVQVPPRIHPTATHHITNEGVPA-----SLPCVASGVPAPT--ITWTKETNALTSRGPH 905
V I PT N V A +L CVA+ P I W K+ L+
Sbjct: 205 NVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISD 264
Query: 906 YNVSKEGTLLIAQPSAQDAGAYVCTA---TNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
+N L I P+ DAG Y C A +++V + LSV P+ R+
Sbjct: 265 HN----RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERH--- 317
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP-PITNRYGLLPSGSLRLAQVQVGD 1021
+TA+ + V + C+AKG PPP +TW KD+ V R+ G L+++ + D
Sbjct: 318 ---ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDD 374
Query: 1022 SGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVR 1080
+G ++C A N AG L V TS P P + G+SV L T + R
Sbjct: 375 TGMFQCFARNAAGEVQTSTYLAV---TSIAPNITRGPLDSTVIDGMSVVLACETSGAPR 430
Score = 85.9 bits (211), Expect = 2e-16
Identities = 64/252 (25%), Positives = 108/252 (42%), Gaps = 8/252 (3%)
Query: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPG 414
F++ + +I + G ++C A + AG + + VT P + P + TV G
Sbjct: 357 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG 416
Query: 415 ETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL---SLEISGIIPTDGGRYQCV 471
+ VL+C G +TW + R+L + + ++ + L SL IS +D G Y C+
Sbjct: 417 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
Query: 472 ASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP--TPHISWSRESQ 529
A+N+ GV AS L+V +++ Q +G + + C + P T W ++
Sbjct: 477 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
Query: 530 ALQEDS--RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 587
L +S RI +D G+L I D G Y+C+ + G D + L P
Sbjct: 537 TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHP 596
Query: 588 AVVLVAVGEEAV 599
L V A+
Sbjct: 597 VATLSTVERRAI 608
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 174 bits (442), Expect = 4e-43
Identities = 175/691 (25%), Positives = 263/691 (38%), Gaps = 74/691 (10%)
Query: 328 LVSCSVHSALPFRLQ-LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS--- 383
L+ C V + P + L G ER F + + S+ + + + GT++C A
Sbjct: 50 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVARDDVT 108
Query: 384 --RAGTGRAKAQIVVTDPPPQLV--PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 439
A + A I + P ++ PA + P L C + G W RD
Sbjct: 109 GEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTP 168
Query: 440 LP-ASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VS 494
L + + +L + P G Y C A +A G +S + A + V
Sbjct: 169 LSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVV 228
Query: 495 IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS-------RIHVDAQGTLII 547
+ ++ E C S P P + W E + + R V A G+L++
Sbjct: 229 LAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLL 288
Query: 548 QGVAPEDAGNYSCQATNEVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 606
V P +AG Y C + G TL+ + + V A EE V G
Sbjct: 289 TQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKG 348
Query: 607 VPPPRVIWYRGGLEMILAPEGSSSG-KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
+P P V W G+ + G +L + E DAG YTC A N G ++ + V
Sbjct: 349 LPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
Query: 666 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP 725
P + P+D +E G+ L C P PTV W R ++ SR
Sbjct: 409 ATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRN-------QMLISEDSRFEVF 461
Query: 726 DSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLE 781
+G L SV D Y C + G ++A+AR+ V PPQ P +
Sbjct: 462 KNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQ-----PQQCMEF 516
Query: 782 GQPVSLPCIVLAGRPLPERHWLK-DGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840
+ ++PC GR P W + DG LP + G+LH R ++ AG Y+C+A
Sbjct: 517 DKEATVPCSA-TGREKPTIKWERADGSSLPEWVTDNA---GTLHFARVTRDDAGNYTCIA 572
Query: 841 TNTAGSQ---HRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETN 897
+N Q H + + V + ++ P T +G A L C A G P P I W +
Sbjct: 573 SNGPQGQIRAHVQLTVAVFITFKVEPERT--TVYQGHTALLQCEAQGDPKPLIQWKGKDR 630
Query: 898 AL--TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN 955
L T GP ++ + G+L+I + +D+G Y C A N+ E L V KP
Sbjct: 631 ILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP----- 685
Query: 956 GSRNANVPLQVTAKAGEEVTLDCEAKGSPPP 986
V + E GSPPP
Sbjct: 686 ------------------VPEESEGPGSPPP 698
Score = 166 bits (421), Expect = 1e-40
Identities = 166/650 (25%), Positives = 254/650 (39%), Gaps = 59/650 (9%)
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 473
G A+L C V P ++ W+ D + + R AQ + LS + D G +QCVA
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR 104
Query: 474 N------ANGVTRASVWLLVREAPQVSIHTSSQ-HFSQGVEVKVSCSASGYPTPHISWSR 526
+ A + + P V H +S+ +V + C G+P P W R
Sbjct: 105 DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFR 164
Query: 527 ESQALQEDSRIHV--DAQGTLIIQGVAPEDAGNYSCQATNEVGT--DQETVTLYYTDPPS 582
+ L + H + L ++ PE +G YSC A + G + TL D
Sbjct: 165 DGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESF 224
Query: 583 VSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWY---------RGGLEMILAPEGSSSG 631
V A V+VA EEA+ C+ S PPP + W R + ++G
Sbjct: 225 ARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANG 284
Query: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP--RDVTVELGRSALLA 689
L + + R+AG Y C + G I A H ++ ++P G +
Sbjct: 285 SLLLTQVRPRNAGIYRCIGQGQRGPPI--ILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 690 CRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG-VLFFESVAPEDQAPYVCEA 747
C G P P+V W G+RL + R G L ++A D Y C A
Sbjct: 343 CLPPKGLPEPSVWWEHA-----GVRLP----THGRVYQKGHELVLANIAESDAGVYTCHA 393
Query: 748 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
N+ G+ + + + V P ++ EG+P L C+ A P P W ++
Sbjct: 394 ANLAGQRRQDVNITVA--TVPSWLKKPQDSQLEEGKPGYLDCLTQA-TPKPTVVWYRNQM 450
Query: 808 PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----QVPPRIHP 863
+ SR + +G+L ++ Y C+++ AGS + V + P P
Sbjct: 451 LISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQP 510
Query: 864 TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 923
E A++PC A+G PTI W + S P + GTL A+ + D
Sbjct: 511 QQCMEFDKE---ATVPCSATGREKPTIKWERADG---SSLPEWVTDNAGTLHFARVTRDD 564
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGS 983
AG Y C A+N ++R V + + P + T G L CEA+G
Sbjct: 565 AGNYTCIASNG---PQGQIRAHVQLTVAVFITFKVE---PERTTVYQGHTALLQCEAQGD 618
Query: 984 PPPLVTWTKDSRPVPP--ITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
P PL+ W R + P + R + +GSL + V DSG Y C A N
Sbjct: 619 PKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN 668
Score = 137 bits (346), Expect = 5e-32
Identities = 136/564 (24%), Positives = 204/564 (36%), Gaps = 58/564 (10%)
Query: 498 SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGN 557
SSQ QG + C H+ W + +Q+ R +D+G
Sbjct: 39 SSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGT 98
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEA--------VLVCEASGVPP 609
+ C A ++V T +E + + VVL EA L C G P
Sbjct: 99 FQCVARDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 610 PRVIWYRGGLEMILAPEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
P W+R G + S L + A +G Y+C A + G A + +
Sbjct: 158 PTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTL 217
Query: 666 GHAPQ----LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR 721
A + + P+DV V A+ C+ + +PPP++ W D P+ R R
Sbjct: 218 SIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRR 277
Query: 722 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 781
+ +G L V P + Y C + G PP I + + +E
Sbjct: 278 ATVFANGSLLLTQVRPRNAGIYRCIGQGQRG--------------PPIILEATLHLAEIE 323
Query: 782 GQPVSLP------------CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL 829
P+ P C+ G P P W G LP R + L L
Sbjct: 324 DMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR-VYQKGHELVLANIA 382
Query: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
+ AG Y+C A N AG + +DV + V P EG P L C+ P PT
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPT 442
Query: 890 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 949
+ W + L S + V K GTL I D Y C ++ G + R+ V K
Sbjct: 443 VVWYR-NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK 501
Query: 950 PRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-DSRPVPP-ITNRYGLL 1007
+ Q + +E T+ C A G P + W + D +P +T+
Sbjct: 502 LKF------TPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDN---- 551
Query: 1008 PSGSLRLAQVQVGDSGHYECTASN 1031
+G+L A+V D+G+Y C ASN
Sbjct: 552 -AGTLHFARVTRDDAGNYTCIASN 574
Score = 123 bits (308), Expect = 1e-27
Identities = 126/517 (24%), Positives = 198/517 (38%), Gaps = 66/517 (12%)
Query: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS 630
+T ++ P S A+ G A+L CE P V W G + +
Sbjct: 29 QTAIVFIKQPSSQDALQ-------GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQ 81
Query: 631 GKLRIPAAQER--DAGTYTCRAVNEL-------GDASAEIQLAVGHAPQLTELPRDVTVE 681
G AA +R D+GT+ C A +++ +AS I+ L + ++
Sbjct: 82 GSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQ 141
Query: 682 LGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQA 741
L C G P PT W R DG PL G+ + + L PE
Sbjct: 142 PQTQVTLRCHIDGHPRPTYQWFR-DGTPLS----DGQSNHTVSSKERNLTLRPAGPEHSG 196
Query: 742 PYVCEARNVFGKVQAEAR--LIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPE 799
Y C A + FG+ + L + + ++ + V V + C + +P P
Sbjct: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHC-QFSAQPPPS 255
Query: 800 RHWL-KDGRPL-----PPGSRHS-IRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 852
WL +D P+ PP R + + A+GSL L + +AG Y C+ G
Sbjct: 256 LQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG------- 308
Query: 853 LVVQVPPRIHPTATHHITNEGVPASLPCVAS-------------GVPAPTITWTKETNAL 899
PP I H E +P P V + G+P P++ W L
Sbjct: 309 -----PPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL 363
Query: 900 TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
+ G Y E L++A + DAG Y C A N G Q++ ++V T P
Sbjct: 364 PTHGRVYQKGHE--LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSW------- 414
Query: 960 ANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQV 1019
P + G+ LDC + +P P V W ++ + +R+ + +G+LR+ V+V
Sbjct: 415 LKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE-DSRFEVFKNGTLRINSVEV 473
Query: 1020 GDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLP 1056
D Y C +S PAGS + + V + + P P
Sbjct: 474 YDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQP 510
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 174 bits (442), Expect = 4e-43
Identities = 124/385 (32%), Positives = 168/385 (43%), Gaps = 22/385 (5%)
Query: 572 TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--- 628
TV + P ++ V V G C A G P P +IW + L +
Sbjct: 225 TVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNV 284
Query: 629 -SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL----AVGHAPQLTELPRDVTVELG 683
G L I +E D G Y C A N G+A + + ++ P P+D V +G
Sbjct: 285 FDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIG 344
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
S L C ATG P P +TW R +G L GSR SG L+ +++ D +
Sbjct: 345 TSTTLECMATGHPHPLITWTRDNGLELD-------GSRHVATSSG-LYLQNITQRDHGRF 396
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
C A N G VQA A +IV APPQ + VLE V C G P P W
Sbjct: 397 TCHANNSHGTVQAAANIIV--QAPPQFTVTPKDQVVLEEHAVEWLC-EADGNPPPVIVWT 453
Query: 804 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP 863
K G LP +H++ + G+L +DRA Q G+Y C A ++ G + V+L V+
Sbjct: 454 KTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
Query: 864 TATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSA 921
T T+ G ++ C A G P P ITW KE +T G ++V EGTL I
Sbjct: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESG-KFHVDDEGTLTIYDAGF 572
Query: 922 QDAGAYVCTATNTVGFSSQEMRLSV 946
D G Y C A N+ G + M L+V
Sbjct: 573 PDQGRYECVARNSFGLAVTNMFLTV 597
Score = 167 bits (424), Expect = 4e-41
Identities = 112/396 (28%), Positives = 168/396 (42%), Gaps = 19/396 (4%)
Query: 657 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 716
AS ++ +P++T P+DV V G + CRA G P P + W + L
Sbjct: 222 ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS-----LDL 276
Query: 717 GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSA 774
+R D G L + DQ Y C ARN G+ + ++ ++ P P
Sbjct: 277 EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQP 336
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 834
VL G +L C+ G P P W +D GSRH + G L+L Q G
Sbjct: 337 QDTEVLIGTSTTLECMA-TGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHG 394
Query: 835 RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 894
R++C A N+ G+ ++VQ PP+ T + E C A G P P I WTK
Sbjct: 395 RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
Query: 895 ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHM 954
L G H V GTL I + + D G Y C A +++G ++L+V K
Sbjct: 455 TGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
Query: 955 NGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRL 1014
+P + + G+ + + C A+G P P++TW K+ + + ++ + G+L +
Sbjct: 514 -----TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITE-SGKFHVDDEGTLTI 567
Query: 1015 AQVQVGDSGHYECTASNPAGSASHRY---VLGVQGR 1047
D G YEC A N G A V +QGR
Sbjct: 568 YDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGR 603
Score = 164 bits (416), Expect = 4e-40
Identities = 114/389 (29%), Positives = 170/389 (43%), Gaps = 21/389 (5%)
Query: 388 GRAKAQIVVTD---PPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443
GRA A + V + P++ P +V V G T +CR G + W+ + L
Sbjct: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
Query: 444 TG-RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL----VREAPQVSIHTS 498
R+ D +L I +D G YQC+A N+ G + +L + P I
Sbjct: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
Query: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 558
G + C A+G+P P I+W+R++ L+ D HV L +Q + D G +
Sbjct: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDN-GLELDGSRHVATSSGLYLQNITQRDHGRF 396
Query: 559 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
+C A N GT Q + PP + +V +CEA G PPP ++W + G
Sbjct: 397 TCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
Query: 619 LEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--GHAPQLTEL 674
++ + + + SSG LRI A + D G Y C+AV+ LG +QL V T+L
Sbjct: 457 GQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL 516
Query: 675 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFES 734
P+D +VE+G++ ++C A G P P +TW + Q + D G L
Sbjct: 517 PQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQ-------ITESGKFHVDDEGTLTIYD 569
Query: 735 VAPEDQAPYVCEARNVFGKVQAEARLIVT 763
DQ Y C ARN FG L VT
Sbjct: 570 AGFPDQGRYECVARNSFGLAVTNMFLTVT 598
Score = 144 bits (363), Expect = 5e-34
Identities = 105/365 (28%), Positives = 155/365 (42%), Gaps = 17/365 (4%)
Query: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLI 546
++P+++ G V +C A G P P I W + S L++D+R++V GTL+
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
Query: 547 IQGVAPEDAGNYSCQATNEVGT--DQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVC 602
I+ D G Y C A N G Q + Y + P PS V +G L C
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
Query: 603 EASGVPPPRVIWYR-GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 661
A+G P P + W R GLE+ + ++S L + +RD G +TC A N G A
Sbjct: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
Query: 662 QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGS 720
+ V PQ T P+D V + C A G PPP + W + GQ P+
Sbjct: 412 NIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EG 463
Query: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
+ SG L + A DQ Y C+A + G + +L V A V
Sbjct: 464 QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840
G+ +++ C G P P W K+G + + + +G+L + A GRY CVA
Sbjct: 524 VGKNINISCHA-QGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
Query: 841 TNTAG 845
N+ G
Sbjct: 583 RNSFG 587
Score = 114 bits (285), Expect = 6e-25
Identities = 86/310 (27%), Positives = 140/310 (45%), Gaps = 14/310 (4%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGETAVLSC 421
I ++++G Y+C A + AG + ++ ++ + P ++ + V G + L C
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
Query: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 481
G +TW RD + + VA + L L+ I D GR+ C A+N++G +A
Sbjct: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQA 409
Query: 482 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541
+ ++V+ PQ ++ Q + V+ C A G P P I W++ L + + V +
Sbjct: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS 469
Query: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 597
GTL I A D G Y CQA + +G + +V L T P AV + V VG+
Sbjct: 470 SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL--TVKPKALAVFTQLPQDTSVEVGKN 527
Query: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPE--GSSSGKLRIPAAQERDAGTYTCRAVNELG 655
+ C A G P P + W + G+++ + + G L I A D G Y C A N G
Sbjct: 528 INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
Query: 656 DASAEIQLAV 665
A + L V
Sbjct: 588 LAVTNMFLTV 597
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/110 (25%), Positives = 44/110 (40%), Gaps = 1/110 (0%)
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP-PITNRYGLLPSGSLRLAQVQVGD 1021
P V +G V C A+G+P P + W ++ + R + G+L + + D
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
Query: 1022 SGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPL 1071
G Y+C A N AG A + + +P + P L G S L
Sbjct: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTL 349
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 167 bits (423), Expect = 6e-41
Identities = 165/579 (28%), Positives = 231/579 (39%), Gaps = 61/579 (10%)
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT----DGGRYQ 469
G VL+C G P W+RD ++L S E IIP+ D G Y+
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRD----------DSELTTYSSEYKYIIPSLQKLDAGFYR 168
Query: 470 CVASNANGVTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKVSCSA-------SGYPTPH 521
CV N G LL R++ QV+ S Q V +A + YP P
Sbjct: 169 CVVRNRMGA------LLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222
Query: 522 ISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---- 577
++W RE + +RI + + L+I DAG Y QA NE + +T +
Sbjct: 223 VTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIA 282
Query: 578 --TDPPSVSAVNAVV------LVAVGEEAVLVCEASGVPPP--RVIWYRGGLEMILAPEG 627
P A VV +VA E L C AS P V W R G+ I +
Sbjct: 283 RDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVR-ITSGLH 341
Query: 628 SSSGKLRIPAAQERDAGTYTCRAV---NELGDASAEIQLAVGHAPQLTELPRD-VTVELG 683
S +L I D G Y C A + A A L + P T P ++ E+
Sbjct: 342 SFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVE 401
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743
+ + C+A G P PT+ W + + + + R + SG L + + PED +
Sbjct: 402 ETVDIGCQAMGVPLPTLQWYKD-----AISISRLQNPRYKVLASGGLRIQKLRPEDSGIF 456
Query: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803
C A N G++Q L VT AP T V +G L C V +G P P W
Sbjct: 457 QCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTT-VTDGMTAILRCEV-SGAPKPAITWK 514
Query: 804 KDGRPLPPGS----RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
++ L GS R + G L + + AG Y+C A NT GS + L V
Sbjct: 515 RENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRT 574
Query: 860 RIHPTATHHITNEGVPASLPCVASGVPAPTI--TWTKETNALT-SRGPHYNVSKEGTLLI 916
I H+ +G A+L C A+ P ++ W K+ ALT S V K+G+LLI
Sbjct: 575 SIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLI 634
Query: 917 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN 955
+Q + D G Y C + G S+ RL V P N
Sbjct: 635 SQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQN 673
Score = 155 bits (393), Expect = 2e-37
Identities = 165/593 (27%), Positives = 247/593 (41%), Gaps = 74/593 (12%)
Query: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQA 562
+G + ++C A G SW E + +++DS + ++ II + DAG Y C
Sbjct: 118 EGNRLVLTCLAEG------SWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVV 171
Query: 563 TNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL-VCEASGVPPPRVIWYRGG 618
N +G + V + Y S + V+ G A+L + + P P+V W+R G
Sbjct: 172 RNRMGALLQRKSEVQVAYMG--SFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREG 229
Query: 619 LEMILAPEGSSS--GKLRIPAAQERDAGTYTCRAVNELGD---ASAEIQLAVGH------ 667
++I + + + +L I A DAG Y +AVNE S I L++
Sbjct: 230 HKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPE 289
Query: 668 --APQLTELPRDVTVELGRS-ALLACRATGRPPP--TVTWRRGDGQPLGLRLGAGRGSRS 722
AP + P + +V G S L C A+ RP +VTW+R G+R+ +G S
Sbjct: 290 TMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRN-----GVRITSGLHSFG 344
Query: 723 RQPDSGVLFFESVAPEDQAPYVCEAR---NVFGKVQAEARLIVTGHAPPQIASSAPTVRV 779
R+ L + D PYVCEA + F +A A L + P ++ P R+
Sbjct: 345 RR-----LTISNPTSADTGPYVCEAALPGSAFEPARATAFLFII---EPPYFTAEPESRI 396
Query: 780 LEG--QPVSLPCIVLAGRPLPERHWLKDGRPLP--PGSRHSIRADGSLHLDRALQEHAGR 835
+ V + C + G PLP W KD + R+ + A G L + + E +G
Sbjct: 397 SAEVEETVDIGCQAM-GVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGI 455
Query: 836 YSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 894
+ C A+N G L V + P +G+ A L C SG P P ITW +
Sbjct: 456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKR 515
Query: 895 ETNALTS---RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
E + L S R P + + + G L IA QDAG Y C A NT G + L+V +
Sbjct: 516 ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS 575
Query: 952 IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV--TWTKDSRPVPPI-TNRYGLLP 1008
I + P G TL C A P + W KD+ + P T+R +
Sbjct: 576 I-------VHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEK 628
Query: 1009 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHP 1061
GSL ++Q GD G Y C + G+ S L V + +PH P
Sbjct: 629 DGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV----------IELPHSP 671
Score = 118 bits (295), Expect = 4e-26
Identities = 135/508 (26%), Positives = 203/508 (39%), Gaps = 59/508 (11%)
Query: 570 QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS 629
Q+ V Y+ P + ++ G VL C A G P W R E+ SS
Sbjct: 99 QDDVAPYFKTEPGLPQIHLE-----GNRLVLTCLAEGSWPLEFKWMRDDSELTTY---SS 150
Query: 630 SGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVGHAPQLTELPRDVTVELGRSA 686
K IP+ Q+ DAG Y C N +G +E+Q+A + + + TV GR+A
Sbjct: 151 EYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVA--YMGSFMDTDQRKTVSQGRAA 208
Query: 687 LL-ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
+L T P P VTW R +G + + + R + + + +L + D Y
Sbjct: 209 ILNLLPITSYPRPQVTWFR-EGHKI---IPSNRIAITLENQLVIL---ATTTSDAGAYYV 261
Query: 746 EA---RNVFGKVQAEARL-IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH 801
+A +N K L I P+ + APT+ V G V+AG
Sbjct: 262 QAVNEKNGENKTSPFIHLSIARDVGTPE--TMAPTIVVPPGNRS-----VVAGSSETTLE 314
Query: 802 WLKDGRPLPPGS----RHSIRADGSLH-------LDRALQEHAGRYSCVATNTAGSQHRD 850
+ RP+ S R+ +R LH + G Y C A GS
Sbjct: 315 CIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA-LPGSAFEP 373
Query: 851 VE----LVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTS-RGP 904
L + PP I+ E + C A GVP PT+ W K+ +++ + P
Sbjct: 374 ARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNP 433
Query: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
Y V G L I + +D+G + C A+N G L V + P+
Sbjct: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQR------PV 487
Query: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT---NRYGLLPSGSLRLAQVQVGD 1021
T G L CE G+P P +TW +++ + + R+ LL SG L++A V + D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
Query: 1022 SGHYECTASNPAGSASHRYVLGVQGRTS 1049
+G+Y C A+N GS + L V RTS
Sbjct: 548 AGNYTCYAANTEGSLNASATLTVWNRTS 575
Score = 115 bits (289), Expect = 2e-25
Identities = 124/442 (28%), Positives = 179/442 (40%), Gaps = 46/442 (10%)
Query: 366 ILRASKAEEGTYECTAVS-RAGTGRAKAQI---VVTDPPPQLVPAPNVTVSPGETAV--- 418
IL + ++ G Y AV+ + G + I + D AP + V PG +V
Sbjct: 248 ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAG 307
Query: 419 -----LSCRVLGEAPYNL--TWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 471
L C +L TW R+ + + + L IS D G Y C
Sbjct: 308 SSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGR----RLTISNPTSADTGPYVCE 363
Query: 472 AS---NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRE 527
A+ +A RA+ +L + E P + S+ ++ E V + C A G P P + W ++
Sbjct: 364 AALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKD 423
Query: 528 SQALQ--EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSA 585
+ ++ ++ R V A G L IQ + PED+G + C A+NE G Q L T+ V
Sbjct: 424 AISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFT 483
Query: 586 VNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---------SSGKLRI 635
V V G A+L CE SG P P + W R E + GS SG L+I
Sbjct: 484 QRPVDTTVTDGMTAILRCEVSGAPKPAITWKR---ENHILASGSVRIPRFMLLESGGLQI 540
Query: 636 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 695
+DAG YTC A N G +A L V + + P D V G +A L C AT
Sbjct: 541 APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
Query: 696 PPPTV--TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
P ++ W++ + + L SR G L D Y CE + G
Sbjct: 601 PRVSLRYVWKKDN-----VALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGN 655
Query: 754 VQAEARL--IVTGHAPPQIASS 773
ARL I H+P + S
Sbjct: 656 DSRMARLEVIELPHSPQNLLVS 677
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 163 bits (413), Expect = 8e-40
Identities = 160/583 (27%), Positives = 224/583 (38%), Gaps = 67/583 (11%)
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSC 560
S+ +VK++C G P PHI W + D R V LI +DAG Y C
Sbjct: 41 SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQC 100
Query: 561 QATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR-----V 612
ATN GT + + Y D + + V V G+ VL+C PPP
Sbjct: 101 TATNSFGTIVSREAKLQFAYLDNFK-TRTRSTVSVRRGQGMVLLCG----PPPHSGELSY 155
Query: 613 IW-------YRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE------LGDASA 659
W Y+ + +G L I ++ D G YTC N LG +
Sbjct: 156 AWIFNEYPSYQDNRRFV----SQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTP 211
Query: 660 EIQLAVG----HAPQL-TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRL 714
I G + P++ + P V G + L C A G P PT+ WRR DG+P+ +
Sbjct: 212 LILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKA 271
Query: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
R +G+L + ED Y C A N GK A +L T +A P
Sbjct: 272 -------RRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL--TFYAQPNWIQKI 322
Query: 775 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 834
+ V + V C GRP P WLK+G PL R I G+L++ AG
Sbjct: 323 NDIHVAMEENVFWECKA-NGRPKPTYKWLKNGEPLLTRDRIQIE-QGTLNITIVNLSDAG 380
Query: 835 RYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT--NEGVPASLPCVASGVPAPTIT 891
Y C+A N G + EL V+ V P T +T G + C P P T
Sbjct: 381 MYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYT 440
Query: 892 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
W K + L +S++G L I + DAG+Y C ATN G +S L V R
Sbjct: 441 WKKGRDIL-KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR 499
Query: 952 IHMNGSRNANVPLQVTAKAGEEVTLDCEA--KGSPPPLVTWTKD------SRPVPPITNR 1003
+ + P + GE + L C+ S + TW+ + R
Sbjct: 500 VMV-------PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERV 552
Query: 1004 YGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046
G +G L + +Q+ +G Y C S L V+G
Sbjct: 553 GGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG 595
Score = 144 bits (363), Expect = 5e-34
Identities = 159/588 (27%), Positives = 222/588 (37%), Gaps = 48/588 (8%)
Query: 394 IVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL 453
I + +P P + P S + L+C V G ++ W + + + +
Sbjct: 27 IFIQEPSPVMFPLD----SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEG 82
Query: 454 SLEISGIIPT-DGGRYQCVASNANG-VTRASVWLLVREAPQVSIHT-SSQHFSQGVEVKV 510
SL I+ T D G YQC A+N+ G + L T S+ +G + +
Sbjct: 83 SLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVL 142
Query: 511 SCSASGYPTPH-----ISWSRESQALQEDSRIHVDAQ-GTLIIQGVAPEDAGNYSCQATN 564
C P PH +W +D+R V + G L I V D GNY+C TN
Sbjct: 143 LCG----PPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTN 198
Query: 565 EVGTDQ----ETVTLYYTD-------PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI 613
V + T + D P V A G L C A G P P +I
Sbjct: 199 TVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTII 258
Query: 614 WYRGGLEMIL--APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL 671
W R + I A S+G L IP Q+ DAG Y C A N G A QL P
Sbjct: 259 WRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNW 318
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF 731
+ D+ V + + C+A GRP PT W + +G+PL R Q + G L
Sbjct: 319 IQKINDIHVAMEENVFWECKANGRPKPTYKWLK-NGEPLLTR-------DRIQIEQGTLN 370
Query: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLPCI 790
V D Y C A N G + + A L V P + V +++ G V + C
Sbjct: 371 ITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECK 430
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD 850
A P P W K L R +I DG+L + + AG Y+C+ATN G+
Sbjct: 431 PKAS-PKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASST 489
Query: 851 VELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNA----LTSRGPHY 906
LVV+ P R+ + G LPC + + I +T N G H+
Sbjct: 490 GNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF 549
Query: 907 ----NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
G L+I + AG YVC +V S L V P
Sbjct: 550 ERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 597
Score = 130 bits (328), Expect = 6e-30
Identities = 137/519 (26%), Positives = 210/519 (40%), Gaps = 47/519 (9%)
Query: 373 EEGTYECTAVSRAGT---GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 429
+ GTY+CTA + GT AK Q D + V+V G+ VL C G P+
Sbjct: 94 DAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRS-TVSVRRGQGMVLLC---GPPPH 149
Query: 430 ----NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA---NGVTRAS 482
+ W+ + R +L I+ + +D G Y CV +N + V
Sbjct: 150 SGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPP 209
Query: 483 VWLLVRE-------APQVSIH-TSSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQE 533
L++R P++ + + ++G VK+ C A G P P I W R + + +
Sbjct: 210 TPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIAR 269
Query: 534 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-YYTDPPSVSAVNAVVLV 592
+R H + G L I EDAG Y C A N G + L +Y P + +N + V
Sbjct: 270 KARRH-KSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKIND-IHV 327
Query: 593 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTCRAV 651
A+ E C+A+G P P W + G ++ G L I DAG Y C A
Sbjct: 328 AMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAE 387
Query: 652 NELG--DASAEIQ-LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
N+ G ++AE+ +AVG T L R V++G ++ C+ P P TW++G
Sbjct: 388 NKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG--- 444
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
R R + G L +V D Y C A N FG + L+V P
Sbjct: 445 ----RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD--PT 498
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLP-ERHWLKDGR--PLPPGSRHSIR-----AD 820
++ ++ V G+ + LPC V L W +G H R +
Sbjct: 499 RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA 558
Query: 821 GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
G L + +HAG+Y C+ + +L+V+ PP
Sbjct: 559 GDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 597
Score = 126 bits (316), Expect = 1e-28
Identities = 129/466 (27%), Positives = 186/466 (39%), Gaps = 36/466 (7%)
Query: 357 QESGNSSWEILRASKAEEGTYEC----TAVSRAGTGRAKAQIVVTD-------PPPQLVP 405
QE+GN I + K++ G Y C T + G I+ D P ++
Sbjct: 174 QETGNLY--IAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQF 231
Query: 406 APNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTD 464
V + G T L C LG + W R D + + R ++ LEI D
Sbjct: 232 PETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARR--HKSNGILEIPNFQQED 289
Query: 465 GGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW 524
G Y+CVA N+ G A L P + H + V C A+G P P W
Sbjct: 290 AGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKW 349
Query: 525 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG---TDQETVTLYYTDPP 581
+ + L RI ++ QGTL I V DAG Y C A N+ G ++ E +
Sbjct: 350 LKNGEPLLTRDRIQIE-QGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDF 408
Query: 582 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKLRIPAA 638
S + + V LV VG E V+ C+ P P W +G +++ E S G LRI
Sbjct: 409 SRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGR-DILKENERITISEDGNLRIINV 467
Query: 639 QERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 698
+ DAG+YTC A N G AS+ L V ++ P + V +G S +L C+ T
Sbjct: 468 TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL 527
Query: 699 TV--TWRRGDGQPLGLRLGAGRGSRSRQPDS-GVLFFESVAPEDQAPYVCEARNVFGKVQ 755
+ TW +G + R DS G L ++ + YVC + ++
Sbjct: 528 DIVFTWSF-NGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLS 586
Query: 756 AEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH 801
A A LIV G P A + + Q L+ RP P+ H
Sbjct: 587 AAADLIVRGPPGPPEAVTIDEITDTTAQ--------LSWRPGPDNH 624
Score = 110 bits (276), Expect = 6e-24
Identities = 90/340 (26%), Positives = 137/340 (40%), Gaps = 16/340 (4%)
Query: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 403
RR + + + + N EI + + G YEC A + G A+ Q+ P +
Sbjct: 260 RRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWI 319
Query: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT 463
++ V+ E C+ G W+++ P T Q+ +L I+ + +
Sbjct: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS 377
Query: 464 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ---GVEVKVSCSASGYPTP 520
D G YQC+A N +GV ++ L V T + + G EV + C P P
Sbjct: 378 DAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKP 437
Query: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 580
+W + L+E+ RI + G L I V DAG+Y+C ATN GT T L DP
Sbjct: 438 VYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDP 497
Query: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI--WYRGGLEMILAPEG---------SS 629
V + + V VGE VL C+ + ++ W G + +G S
Sbjct: 498 TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS 557
Query: 630 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
+G L I Q + AG Y C + SA L V P
Sbjct: 558 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 597
Score = 70.5 bits (171), Expect = 9e-12
Identities = 80/308 (25%), Positives = 118/308 (38%), Gaps = 31/308 (10%)
Query: 763 TGHAPPQIASSAPTVRVLEGQP--VSLPCIVLAGRPLPERHWLKDGRPLPPGS--RHSIR 818
T H P I +P + L+ + V L C V G P P W +G + G R+S+
Sbjct: 22 TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEV-KGNPKPHIRWKLNGTDVDTGMDFRYSV- 79
Query: 819 ADGSLHLDRALQ-EHAGRYSCVATNTAGS-QHRDVELVVQVPPRIHPTATHHIT-NEGVP 875
+GSL ++ + + AG Y C ATN+ G+ R+ +L ++ G
Sbjct: 80 VEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQG 139
Query: 876 ASLPCVASGVPAP-----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCT 930
L C P P + W + + G L IA+ D G Y C
Sbjct: 140 MVLLCG----PPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCV 195
Query: 931 ATNTVGFSSQEMRLSVNTKPRIHMNGSRN-------ANVPLQVTAKAGEEVTLDCEAKGS 983
TNTV + L T + +G P V G V L+C A G+
Sbjct: 196 VTNTV---TNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGN 252
Query: 984 PPPLVTWTK-DSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVL 1042
P P + W + D +P+ R+ +G L + Q D+G YEC A N G R L
Sbjct: 253 PVPTIIWRRADGKPIARKARRHK--SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL 310
Query: 1043 GVQGRTSW 1050
+ +W
Sbjct: 311 TFYAQPNW 318
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 160 bits (405), Expect = 7e-39
Identities = 180/712 (25%), Positives = 289/712 (40%), Gaps = 76/712 (10%)
Query: 400 PPQLVPAPNVT--------VSPGETAVLSCRVLGEAPYNLTWVRDWRVLP-ASTGRVA-- 448
P L P +T V P + ++ C G + W R+ R A RV+
Sbjct: 28 PMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
Query: 449 -QLADLSLEI-SGIIPTD-GGRYQCVASNANGVTRAS-VWLLVREAPQ-VSIHTSSQHFS 503
+ L ++ SG P + G YQC A N G ++ + L V ++P +
Sbjct: 88 RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ 147
Query: 504 QGVEVKVSCSAS-GYPTPHISWSRES-QALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSC 560
+G + + C+ G P+P I W S + + +D R+ G L V +D +YSC
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSC 207
Query: 561 QA--------------TNEVGTDQETVTLYYTDPPSVSAVNAVV---------------- 590
A T +V T+ + P + + V
Sbjct: 208 NARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQ 267
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTC 648
+V G + +L C ASGVP P + WY+ G L A + + LRI E D+G Y C
Sbjct: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
A N++G I + V AP + P+++ + G L CRA G P PTV W +G+
Sbjct: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMV-NGE 386
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
PL + + +R+ + F +A Y C N G + A A + V P
Sbjct: 387 PLQ----SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 442
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDR 827
++ +RV+ L C G P+P W K+G+ G + + +GSL +
Sbjct: 443 MLSPRNQLIRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 501
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
+E G Y+CVATN G V L V+ P RI+ + G L C P+
Sbjct: 502 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPS 561
Query: 888 P--TITWTKETNALTSRGPHYNVSKEG-TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
T++W K+ L + KE +L I + +D G+Y C A+ + + L
Sbjct: 562 LKLTVSWLKDDEPLYIGN---RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYL 618
Query: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVT-LDCEAKGSP-PPLVTWTKDSRPVPPITN 1002
+V +P R ++ L A+ +T + +A SP V ++ + P + +
Sbjct: 619 TVLGRP------DRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWH 672
Query: 1003 RYGLLPSGSLRLAQVQVGDSGHYE--CTASNPAGSASHRYVLGVQGRTSWQP 1052
+ P GS+ A +++ +Y+ A N GS SH + + RTS P
Sbjct: 673 DHSKYP-GSVNSAVLRLSPYVNYQFRVIAINEVGS-SHPSLPSERYRTSGAP 722
Score = 108 bits (270), Expect = 3e-23
Identities = 108/413 (26%), Positives = 162/413 (39%), Gaps = 50/413 (12%)
Query: 660 EIQLAVGHAPQLT-ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 718
EI + + P +T + +D V+ + L+ C A G P P+ W R + + +
Sbjct: 26 EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRV 84
Query: 719 GSRSRQPDSGVLFFESVAPED-QAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 777
R R + F PE+ + Y C ARN FG + + +P + V
Sbjct: 85 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV 144
Query: 778 RVLEGQPVSLPCIVLAGRPLPERHWLKDG-RPLPPGSRHSIRADGSLHLDRA-LQEHAGR 835
V EG P++L C G P P W+ P+ R S +G L+ LQ+
Sbjct: 145 VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD 204
Query: 836 YSCVA----TNTAGSQHRDVELVVQVPP------RIHP--------------------TA 865
YSC A T+T ++ V+ P R HP TA
Sbjct: 205 YSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTA 264
Query: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALTS-RGPHYNVSKEGTLLIAQPSAQDA 924
+ + G+ L C+ASGVP P I W K+ L S + N +K L I S +D+
Sbjct: 265 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK--ALRITNVSEEDS 322
Query: 925 GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
G Y C A+N +G + + V P + P + GE+ L C A G+P
Sbjct: 323 GEYFCLASNKMGSIRHTISVRVKAAPYW-------LDEPKNLILAPGEDGRLVCRANGNP 375
Query: 985 PPLVTWTKDSRPV---PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
P V W + P+ PP NR + ++ Q+ Y+C SN G
Sbjct: 376 KPTVQWMVNGEPLQSAPPNPNRE--VAGDTIIFRDTQISSRAVYQCNTSNEHG 426
Score = 96.3 bits (238), Expect = 2e-19
Identities = 86/330 (26%), Positives = 135/330 (40%), Gaps = 14/330 (4%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 417
E+ N + I S+ + G Y C A ++ G+ R + V P L N+ ++PGE
Sbjct: 306 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 365
Query: 418 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
L CR G + W+ + L P + R ++A ++ + YQC SN
Sbjct: 366 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTIIFRDTQISSRAVYQCNTSN 423
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQ 532
+G A+ ++ V + P + +Q + ++ C G P P + W + Q
Sbjct: 424 EHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN 483
Query: 533 ED-SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591
D HV G+L I+ + ED G Y+C ATN +G + V L DP + + +
Sbjct: 484 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 543
Query: 592 VAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 648
G L C P + V W + + + L I ERD G+YTC
Sbjct: 544 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 603
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDV 678
A EL A+ L V P + PRD+
Sbjct: 604 VASTELDQDLAKAYLTVLGRP---DRPRDL 630
Score = 72.4 bits (176), Expect = 2e-12
Identities = 80/332 (24%), Positives = 128/332 (38%), Gaps = 51/332 (15%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR--PLPPGSRHSIRA-DGSL 823
PP I + +++ + L G P P HW ++ R + R S+R G+L
Sbjct: 34 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
Query: 824 HLDRAL----QEHAGRYSCVATNTAGSQHRD-VELVVQVPP-----RIHPTATHHITNEG 873
+D +E+ G Y C A N G+ + + L V P + P + EG
Sbjct: 94 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEG 149
Query: 874 VPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA-YVCTA 931
P +L C G+P+P I W + ++ + G L + QD Y C A
Sbjct: 150 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
Query: 932 ----TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA----------------- 970
T+T+ Q+ ++ N S N P +A+
Sbjct: 210 RFHFTHTI---QQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 971 -----GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
G ++ L+C A G P P + W K +P ++ + +LR+ V DSG Y
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITNVSEEDSGEY 325
Query: 1026 ECTASNPAGSASHRYVLGVQGRTSW--QPQSL 1055
C ASN GS H + V+ W +P++L
Sbjct: 326 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNL 357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 4/159 (2%)
Query: 335 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
S +P + G+ + ++ N S EI K ++G Y C A + G + ++
Sbjct: 468 SPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 527
Query: 395 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLAD 452
V DP + G T L CRV + LT W++D P G + D
Sbjct: 528 EVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKED 585
Query: 453 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
SL I G+ D G Y CVAS A +L V P
Sbjct: 586 DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRP 624
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 160 bits (405), Expect = 7e-39
Identities = 180/712 (25%), Positives = 289/712 (40%), Gaps = 76/712 (10%)
Query: 400 PPQLVPAPNVT--------VSPGETAVLSCRVLGEAPYNLTWVRDWRVLP-ASTGRVA-- 448
P L P +T V P + ++ C G + W R+ R A RV+
Sbjct: 28 PMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
Query: 449 -QLADLSLEI-SGIIPTD-GGRYQCVASNANGVTRAS-VWLLVREAPQ-VSIHTSSQHFS 503
+ L ++ SG P + G YQC A N G ++ + L V ++P +
Sbjct: 88 RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ 147
Query: 504 QGVEVKVSCSAS-GYPTPHISWSRES-QALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSC 560
+G + + C+ G P+P I W S + + +D R+ G L V +D +YSC
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSC 207
Query: 561 QA--------------TNEVGTDQETVTLYYTDPPSVSAVNAVV---------------- 590
A T +V T+ + P + + V
Sbjct: 208 NARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQ 267
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTC 648
+V G + +L C ASGVP P + WY+ G L A + + LRI E D+G Y C
Sbjct: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
A N++G I + V AP + P+++ + G L CRA G P PTV W +G+
Sbjct: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMV-NGE 386
Query: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
PL + + +R+ + F +A Y C N G + A A + V P
Sbjct: 387 PLQ----SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 442
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDR 827
++ +RV+ L C G P+P W K+G+ G + + +GSL +
Sbjct: 443 MLSPRNQLIRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 501
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
+E G Y+CVATN G V L V+ P RI+ + G L C P+
Sbjct: 502 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPS 561
Query: 888 P--TITWTKETNALTSRGPHYNVSKEG-TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
T++W K+ L + KE +L I + +D G+Y C A+ + + L
Sbjct: 562 LKLTVSWLKDDEPLYIGN---RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYL 618
Query: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVT-LDCEAKGSP-PPLVTWTKDSRPVPPITN 1002
+V +P R ++ L A+ +T + +A SP V ++ + P + +
Sbjct: 619 TVLGRP------DRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWH 672
Query: 1003 RYGLLPSGSLRLAQVQVGDSGHYE--CTASNPAGSASHRYVLGVQGRTSWQP 1052
+ P GS+ A +++ +Y+ A N GS SH + + RTS P
Sbjct: 673 DHSKYP-GSVNSAVLRLSPYVNYQFRVIAINEVGS-SHPSLPSERYRTSGAP 722
Score = 108 bits (270), Expect = 3e-23
Identities = 108/413 (26%), Positives = 162/413 (39%), Gaps = 50/413 (12%)
Query: 660 EIQLAVGHAPQLT-ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 718
EI + + P +T + +D V+ + L+ C A G P P+ W R + + +
Sbjct: 26 EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRV 84
Query: 719 GSRSRQPDSGVLFFESVAPED-QAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 777
R R + F PE+ + Y C ARN FG + + +P + V
Sbjct: 85 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV 144
Query: 778 RVLEGQPVSLPCIVLAGRPLPERHWLKDG-RPLPPGSRHSIRADGSLHLDRA-LQEHAGR 835
V EG P++L C G P P W+ P+ R S +G L+ LQ+
Sbjct: 145 VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD 204
Query: 836 YSCVA----TNTAGSQHRDVELVVQVPP------RIHP--------------------TA 865
YSC A T+T ++ V+ P R HP TA
Sbjct: 205 YSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTA 264
Query: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALTS-RGPHYNVSKEGTLLIAQPSAQDA 924
+ + G+ L C+ASGVP P I W K+ L S + N +K L I S +D+
Sbjct: 265 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK--ALRITNVSEEDS 322
Query: 925 GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
G Y C A+N +G + + V P + P + GE+ L C A G+P
Sbjct: 323 GEYFCLASNKMGSIRHTISVRVKAAPYW-------LDEPKNLILAPGEDGRLVCRANGNP 375
Query: 985 PPLVTWTKDSRPV---PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
P V W + P+ PP NR + ++ Q+ Y+C SN G
Sbjct: 376 KPTVQWMVNGEPLQSAPPNPNRE--VAGDTIIFRDTQISSRAVYQCNTSNEHG 426
Score = 96.3 bits (238), Expect = 2e-19
Identities = 86/330 (26%), Positives = 135/330 (40%), Gaps = 14/330 (4%)
Query: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 417
E+ N + I S+ + G Y C A ++ G+ R + V P L N+ ++PGE
Sbjct: 306 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 365
Query: 418 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
L CR G + W+ + L P + R ++A ++ + YQC SN
Sbjct: 366 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTIIFRDTQISSRAVYQCNTSN 423
Query: 475 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQ 532
+G A+ ++ V + P + +Q + ++ C G P P + W + Q
Sbjct: 424 EHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN 483
Query: 533 ED-SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591
D HV G+L I+ + ED G Y+C ATN +G + V L DP + + +
Sbjct: 484 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 543
Query: 592 VAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 648
G L C P + V W + + + L I ERD G+YTC
Sbjct: 544 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 603
Query: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDV 678
A EL A+ L V P + PRD+
Sbjct: 604 VASTELDQDLAKAYLTVLGRP---DRPRDL 630
Score = 72.4 bits (176), Expect = 2e-12
Identities = 80/332 (24%), Positives = 128/332 (38%), Gaps = 51/332 (15%)
Query: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR--PLPPGSRHSIRA-DGSL 823
PP I + +++ + L G P P HW ++ R + R S+R G+L
Sbjct: 34 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
Query: 824 HLDRAL----QEHAGRYSCVATNTAGSQHRD-VELVVQVPP-----RIHPTATHHITNEG 873
+D +E+ G Y C A N G+ + + L V P + P + EG
Sbjct: 94 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEG 149
Query: 874 VPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA-YVCTA 931
P +L C G+P+P I W + ++ + G L + QD Y C A
Sbjct: 150 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
Query: 932 ----TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA----------------- 970
T+T+ Q+ ++ N S N P +A+
Sbjct: 210 RFHFTHTI---QQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 971 -----GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
G ++ L+C A G P P + W K +P ++ + +LR+ V DSG Y
Sbjct: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITNVSEEDSGEY 325
Query: 1026 ECTASNPAGSASHRYVLGVQGRTSW--QPQSL 1055
C ASN GS H + V+ W +P++L
Sbjct: 326 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNL 357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 4/159 (2%)
Query: 335 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
S +P + G+ + ++ N S EI K ++G Y C A + G + ++
Sbjct: 468 SPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 527
Query: 395 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLAD 452
V DP + G T L CRV + LT W++D P G + D
Sbjct: 528 EVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKED 585
Query: 453 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 491
SL I G+ D G Y CVAS A +L V P
Sbjct: 586 DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRP 624
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 155 bits (393), Expect = 2e-37
Identities = 194/719 (26%), Positives = 289/719 (40%), Gaps = 114/719 (15%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV----TVSPGETAVLSC 421
+ +A K + G Y C A + R ++ +T+P +V G +A+LSC
Sbjct: 1041 VQQAGKTDAGDYSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSC 1096
Query: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISG-----IIP----TDGGRYQCVA 472
V +A +TW +D + L +S+ + +E+ G ++P D G Y C A
Sbjct: 1097 EV-AQAQTEVTWYKDGKKLSSSS-------KVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 473 SNANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRE 527
G R S L + E A + S+H Q G +SC + P ++W ++
Sbjct: 1149 ----GGQRVSFHLHITEPKGVFAKEQSVHNEVQA-EAGTTAMLSCEVA-QPQTEVTWYKD 1202
Query: 528 SQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 584
+ L S++ ++ +G L++Q V DAG YSC+A G + + L+ T+P +V
Sbjct: 1203 GKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEA----GGQRVSFQLHITEPKAVF 1258
Query: 585 A----VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPA--- 637
A V+ V G A L CE + V WY+ G ++ SSS K+RI A
Sbjct: 1259 AKEQLVHNEVRTEAGASATLSCEVAQA-QTEVTWYKDGKKL------SSSSKVRIEAAGC 1311
Query: 638 --------AQERDAGTYTCRAVNELGDASAEIQ--LAVGHAPQLTELPRDVTVELGRSAL 687
A + DAG YTC A + ++ AV QL R V E G A
Sbjct: 1312 MRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAH--RKVQAEAGAIAT 1369
Query: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYV 744
L+C + VTW + DG+ L S+ R G L + D Y
Sbjct: 1370 LSCE-VAQAQTEVTWYK-DGKKL------SSSSKVRMEAVGCTRRLVVQQACQADTGEYS 1421
Query: 745 CEA---RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH 801
CEA R F AE +++ P V+ G +L C V + E
Sbjct: 1422 CEAGGQRLSFSLDVAEPKVVFAKEQPVH-----REVQAQAGASTTLSCEVAQAQ--TEVM 1474
Query: 802 WLKDGRPLPPGSRHSIRADG---SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
W KDG+ L S+ + A G L + +A Q AG YSC AGSQ L V P
Sbjct: 1475 WYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSC----EAGSQRLSFHLHVAEP 1530
Query: 859 PRI----HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP--HYNVSKEG 912
+ P + G A+L C + +TW K+ L+S V
Sbjct: 1531 KAVFAKEQPASREVQAEAGTSATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTR 1589
Query: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
L++ + DAG Y C A G L V +P++ + A+ +V A+AG
Sbjct: 1590 RLVVQEAGQADAGEYSCKA----GDQRLSFHLHV-AEPKVVFAKEQPAH--REVQAEAGA 1642
Query: 973 EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG--DSGHYECTA 1029
TL CE + VTW KD + + + + RL Q G D+G Y C A
Sbjct: 1643 SATLSCEVAQAQTE-VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 152 bits (383), Expect = 2e-36
Identities = 181/715 (25%), Positives = 287/715 (40%), Gaps = 74/715 (10%)
Query: 353 ERHFQESGNSSWEILRAS--KAEEGTYECTAVSRAGTGRAKAQIVVTDPP----PQLVPA 406
ER QE + ++ A+ + +EGTY C R G ++ V++P + +
Sbjct: 842 ERFLQEDVGTRHRLVAATVTRQDEGTYSC----RVGEDSVDFRLRVSEPKVVFAKEQLAR 897
Query: 407 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGIIPTD 464
+ G +A LSC V +A +TW +D + L +S+ + + L + D
Sbjct: 898 RKLQAEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQAD 956
Query: 465 GGRYQCVASNANGVTRASVWLLVREAPQV----SIHTSSQHFSQGVEVKVSCSASGYPTP 520
G Y C A G R S L V+E V + S G +SC + T
Sbjct: 957 AGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT- 1011
Query: 521 HISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
+ W ++ + L ++HV+A+G L++Q DAG+YSC+A + + + L+
Sbjct: 1012 EVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQ----RVSFRLHI 1067
Query: 578 TDPPSVSA----VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GS 628
T+P + A V+ V G A+L CE + V WY+ G ++ + +
Sbjct: 1068 TEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQA-QTEVTWYKDGKKLSSSSKVGMEVKG 1126
Query: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
+ +L +P A + DAG Y+C A + I G + + +V E G +A+L
Sbjct: 1127 CTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAML 1186
Query: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYVC 745
+C +P VTW + DG+ L S+ R G L + V D Y C
Sbjct: 1187 SCE-VAQPQTEVTWYK-DGKKL------SSSSKVRMEVKGCTRRLVVQQVGKADAGEYSC 1238
Query: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
EA Q A Q+ + VR G +L C V + E W KD
Sbjct: 1239 EAGGQRVSFQLHITEPKAVFAKEQLVHN--EVRTEAGASATLSCEVAQAQ--TEVTWYKD 1294
Query: 806 GRPLPPGSRHSIRADG---SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH 862
G+ L S+ I A G L + +A Q AG Y+C A S H DV V +
Sbjct: 1295 GKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQ 1354
Query: 863 PTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP--HYNVSKEGTLLIAQPS 920
G A+L C + +TW K+ L+S V L++ Q
Sbjct: 1355 LAHRKVQAEAGAIATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413
Query: 921 AQDAGAYVCTATNTVGFSSQEMRLSVN-TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
D G Y C A Q + S++ +P++ ++ V +V A+AG TL CE
Sbjct: 1414 QADTGEYSCEA------GGQRLSFSLDVAEPKVVF--AKEQPVHREVQAQAGASTTLSCE 1465
Query: 980 AKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGD---SGHYECTASN 1031
+ V W KD + + +++ + G R VQ +G Y C A +
Sbjct: 1466 VAQAQTE-VMWYKDGKKL-SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518
Score = 136 bits (342), Expect = 1e-31
Identities = 182/704 (25%), Positives = 284/704 (40%), Gaps = 94/704 (13%)
Query: 370 SKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAP 428
S + G Y C G+ +A++ V D + + V GE+ C + E+
Sbjct: 2709 SPEDAGLYTC----HVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764
Query: 429 YN-LTWVRDWRVLPASTGRVA--QLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
+ W + + +S+ A Q L + P+D G V + G+T + L
Sbjct: 2765 SDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE---VVFSVRGLT-SKASL 2820
Query: 486 LVREAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 544
+VRE P I Q + G +V++ C S TP + W ++ +A+++ + V +GT
Sbjct: 2821 IVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEGT 2879
Query: 545 ---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL-VAVGEEAVL 600
L+I+G + +DAG Y+C EV + T +L+ + + L V AV
Sbjct: 2880 MAMLVIRGASLKDAGEYTC----EVEASKSTASLHVEEKANCFTEELTNLQVEEKGTAVF 2935
Query: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSG-----KLRIPAAQERDAGTYTCRAVNELG 655
C+ P V W +G LE+ + + S +L I A ++ D+ TYTC ++G
Sbjct: 2936 TCKTEH-PAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTC----DIG 2990
Query: 656 DASAEIQLAV-GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW------------ 702
A + QL V G + E DV V+ G SA CR + V W
Sbjct: 2991 QAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANEL 3050
Query: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
D QP G + R + DSG ++FE+ G +A A L V
Sbjct: 3051 NEIDAQPGGYHVLTLR--QLALKDSGTIYFEA-----------------GDQRASAALRV 3091
Query: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG- 821
T P + + EG+ ++L C + +P W KDG+ L +R + +G
Sbjct: 3092 T-EKPSVFSRELTDATITEGEDLTLVC-ETSTCDIPV-CWTKDGKTLRGSARCQLSHEGH 3148
Query: 822 --SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 879
L + A + +GRY C A G+ + V P R EG A+L
Sbjct: 3149 RAQLLITGATLQDSGRYKCEA---GGACSSSIVRVHARPVRFQEALKDLEVLEGGAATLR 3205
Query: 880 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVG 936
CV S V AP + W N L G Y++ +EG +L + QD+G Y C + G
Sbjct: 3206 CVLSSVAAP-VKWCYGNNVLRP-GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFG 3259
Query: 937 FSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRP 996
+ L+V P + RN A G TL CE + P V W K S
Sbjct: 3260 DQTTSATLTVTALPAQFIGKLRNKE------ATEGATATLRCELSKAAP--VEWRKGSET 3311
Query: 997 VPPITNRYGLLPSGS---LRLAQVQVGDSGHYECTASNPAGSAS 1037
+ +RY L G+ L++ + + D+ Y C SAS
Sbjct: 3312 LRD-GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSAS 3354
Score = 129 bits (324), Expect = 2e-29
Identities = 189/740 (25%), Positives = 272/740 (36%), Gaps = 96/740 (12%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHF---QESGNSSWEILRASKAEEGTYECTAVSRAGT 387
C + A P ++ R+G L + + Q+ +I + + Y C G
Sbjct: 3295 CELSKAAP--VEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVC----GE 3348
Query: 388 GRAKAQIVVTDPPPQLVPAPNVTVS-PGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR 446
R A + + P + S G TA L C + AP + W + L
Sbjct: 3349 ERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSKAAP--VEWRKGRESLRDGDRH 3406
Query: 447 VAQL--ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP-QVSIHTSSQHFS 503
+ A L+I G+ D G Y CV G R S L V+ P + + ++
Sbjct: 3407 SLRQDGAVCELQICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV 3462
Query: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSC 560
+G + C S + W + + L++ R + +GT L I G+A DAG Y C
Sbjct: 3463 EGATAMLWCELS--KVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC 3520
Query: 561 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA-VGEEAVLVCEASGVPPPRVIWYRG-- 617
G ++ + TL P+ + A G AVL CE + P V W +G
Sbjct: 3521 VC----GQERTSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSE 3574
Query: 618 ----GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLT 672
G L +G+ +L+I D G Y+C G L V P + T
Sbjct: 3575 TLRDGDRYSLRQDGTKC-ELQIRGLAMADTGEYSCVC----GQERTSAMLTVRALPIKFT 3629
Query: 673 ELPRDVTVELGRSALLACRATGRPPPTVTWRRG-----DGQPLGLRLGAGRGSRSRQPDS 727
E R+ G +A+L C + P V W +G DG LR R
Sbjct: 3630 EGLRNEEATEGATAVLRCELSKMAP--VEWWKGHETLRDGDRHSLRQDGARCE------- 3680
Query: 728 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
L + ED Y+C + GK + A L V P + EG +L
Sbjct: 3681 --LQIRGLVAEDAGEYLC----MCGKERTSAMLTVRA-MPSKFIEGLRNEEATEGDTATL 3733
Query: 788 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTA 844
C + P+ W K L G RHS+R DGS L + AG YSCV
Sbjct: 3734 WCELSKAAPV---EWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCV----C 3786
Query: 845 GSQHRDVELVVQ-VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
G + L V+ +P R + EG A L C S A + W K + L G
Sbjct: 3787 GQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELS--KAAPVEWRKGSETLRG-G 3843
Query: 904 PHYNVSKEGT---LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
Y++ ++GT L I S D G Y C G L+V +
Sbjct: 3844 DRYSLRQDGTRCELQIHGLSVADTGEYSCVC----GQERTSATLTVRAPQPVFRE----- 3894
Query: 961 NVPLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLP--SGSLRLAQV 1017
PLQ + A+ G TL CE P V W+K + R L + L L +
Sbjct: 3895 --PLQSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDL 3951
Query: 1018 QVGDSGHYECTASNPAGSAS 1037
Q D+G Y CT + A SA+
Sbjct: 3952 QREDTGEYTCTCGSQATSAT 3971
Score = 116 bits (291), Expect = 1e-25
Identities = 119/482 (24%), Positives = 188/482 (39%), Gaps = 74/482 (15%)
Query: 401 PQLVPAPNV-TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-RVAQLADL-SLEI 457
P+ + P VS G+ A LSC+++G ++W +D + + A R+AQ DL L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLV-------REAPQVSIHTSSQHFSQGVEVKV 510
+ D G+Y C A NA G A+V L V +AP + +S +G E
Sbjct: 70 LDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATF 129
Query: 511 SCSASGYPTPHISWSRESQALQEDS--RIHVDAQG---TLIIQGVAPEDAGNYSCQATNE 565
C G P P +SWS++ + L E R+ V+ G L I+ P D G Y +A N
Sbjct: 130 RCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENP 189
Query: 566 VGTDQETVTLYY-----------------------------------TDPPSVSAVNAVV 590
+G L PPS
Sbjct: 190 LGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTG--TRTC 247
Query: 591 LVAVGEEAVLVCEASGVPPPRVIWYRG------GLEMILAPEGSSSGKLRIPAAQERDAG 644
V G+ A L C +G P P +W + G ++ + + L+I ++ D G
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRG 307
Query: 645 TYTCRAVNELGDASAEIQLAVGH-APQLTELPRDVTVELGRSALLACRATGRPPPTVTWR 703
YTC A N +G + + + V A + +D+ V SA C +P W
Sbjct: 308 LYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVP-QPSTEAAWF 366
Query: 704 RGDGQP-LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
+ + + + G R+ L +V+ +D A Y+CE V A L V
Sbjct: 367 KEETRLWASAKYGIEEEGTERR-----LTVRNVSADDDAVYICETPEGSRTV---AELAV 418
Query: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 822
G+ + P + ++ C+ LA P+ HWL++ + G R +I A+G+
Sbjct: 419 QGN----LLRKLPRKTAVRVGDTAMFCVELA-VPVGPVHWLRNQEEVVAGGRVAISAEGT 473
Query: 823 LH 824
H
Sbjct: 474 RH 475
Score = 116 bits (290), Expect = 1e-25
Identities = 182/739 (24%), Positives = 278/739 (37%), Gaps = 86/739 (11%)
Query: 331 CSVHSALPFRLQLRRGEARLGEERHF---QESGNSSWEILRASKAEEGTYECTAVSRAGT 387
C + P ++ R+G L + + QE +I + A+ G Y C G
Sbjct: 3471 CELSKVAP--VEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC----GQ 3524
Query: 388 GRAKAQIVVTDPPPQLVP-APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR 446
R A + + P + + N G TAVL C + AP + W + L R
Sbjct: 3525 ERTSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSETL-RDGDR 3581
Query: 447 VAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP-QVSIHTSSQHF 502
+ D L+I G+ D G Y CV G R S L VR P + + ++
Sbjct: 3582 YSLRQDGTKCELQIRGLAMADTGEYSCVC----GQERTSAMLTVRALPIKFTEGLRNEEA 3637
Query: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYS 559
++G + C S + W + + L++ R + G L I+G+ EDAG Y
Sbjct: 3638 TEGATAVLRCELSKMAP--VEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYL 3695
Query: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWYRG- 617
C G ++ + L PS A G+ A L CE S P V W +G
Sbjct: 3696 CMC----GKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAP--VEWRKGH 3749
Query: 618 -----GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 672
G L +GS +L+I DAG Y+C E A+ ++ +
Sbjct: 3750 ETLRDGDRHSLRQDGSRC-ELQIRGLAVVDAGEYSCVCGQERTSATLTVRALPA---RFI 3805
Query: 673 ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFF 732
E ++ G +A+L C + P V WR+G LR G R S + L
Sbjct: 3806 EDVKNQEAREGATAVLQCELSKAAP--VEWRKGSET---LR-GGDRYSLRQDGTRCELQI 3859
Query: 733 ESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP-PQIASSAPTVRVLEGQPVSLPCIV 791
++ D Y C V G+ + A L V AP P +++ EG +L C +
Sbjct: 3860 HGLSVADTGEYSC----VCGQERTSATLTV--RAPQPVFREPLQSLQAEEGSTATLQCEL 3913
Query: 792 LAGRPLPERHWLKDGRPLPPGSRHSIRADG---SLHLDRALQEHAGRYSCVATNTAGSQH 848
P W K G L R R G L L +E G Y+C T GSQ
Sbjct: 3914 --SEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTC----TCGSQA 3967
Query: 849 RDVELVVQVPP-RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN 907
L V P R H +EG A L C S A ++ W K + L Y
Sbjct: 3968 TSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGA-SVEWRKGSLQLFPCAK-YQ 4025
Query: 908 VSKEGT---LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
+ ++G LL+ +DAG Y C +T +S +R+ +P+
Sbjct: 4026 MVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVP---RPKFKTRLQ------- 4075
Query: 965 QVTAKAGEEVTLDCEAKGSPP-PLVTWTKDSRPVPPITNRYGLLPSGSLR---LAQVQVG 1020
+ + G+ L C+ + +V W K+ + +Y + G+ R + Q++
Sbjct: 4076 SLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHA-GPKYEMRSQGATRELLIHQLEAK 4134
Query: 1021 DSGHYECTASNPAGSASHR 1039
D+G Y C +AS R
Sbjct: 4135 DTGEYACVTGGQKTAASLR 4153
Score = 112 bits (279), Expect = 3e-24
Identities = 126/491 (25%), Positives = 182/491 (37%), Gaps = 66/491 (13%)
Query: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI--- 546
AP+ + S G + +SC G PTP +SW ++ Q + +R + G L
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLT 68
Query: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAV--------VLVAVGEEA 598
I +A D+G Y C+A N +G V L D + A A + V G EA
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQ-VDAEAACAEQAPHFLLRPTSIRVREGSEA 127
Query: 599 VLVCEASGVPPPRVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAV 651
C G P P V W + G + + E + LRI AA+ RD GTY RA
Sbjct: 128 TFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAE 187
Query: 652 NELGDASAEIQLAV-------------------GHAPQLTEL--------------PRDV 678
N LG ASA L V H + E R
Sbjct: 188 NPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTC 247
Query: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
TV G+ A L+C TG P P W++ DGQ + G ++ VL
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVWKK-DGQL--VTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP 798
D+ Y C A N+ G+ + ++V A P + V E + + C V +P
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVREPAVP-FKKRLQDLEVREKESATFLCEV--PQPST 361
Query: 799 ERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
E W K+ L +++ I +G+ A + T EL VQ
Sbjct: 362 EAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGN 421
Query: 859 -PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TL 914
R P T + ++ CV VP + W + + + G +S EG TL
Sbjct: 422 LLRKLPRKTAVRVGD---TAMFCVELAVPVGPVHWLRNQEEVVA-GGRVAISAEGTRHTL 477
Query: 915 LIAQPSAQDAG 925
I+Q +D G
Sbjct: 478 TISQCCLEDVG 488
Score = 105 bits (261), Expect = 3e-22
Identities = 176/697 (25%), Positives = 256/697 (36%), Gaps = 81/697 (11%)
Query: 331 CSVHSALPFRLQLRRGEARLGE-ERHF--QESGNSSWEILRASKAEEGTYECTAVSRAGT 387
C + A P ++ R+G L + +RH Q+ +I + + G Y C G
Sbjct: 3735 CELSKAAP--VEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQ 3788
Query: 388 GRAKAQIVVTDPPPQLVP-APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR 446
R A + V P + + N G TAVL C + AP + W + L R
Sbjct: 3789 ERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAP--VEWRKGSETLRGGD-R 3845
Query: 447 VAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 503
+ D L+I G+ D G Y CV G R S L VR APQ Q
Sbjct: 3846 YSLRQDGTRCELQIHGLSVADTGEYSCVC----GQERTSATLTVR-APQPVFREPLQSLQ 3900
Query: 504 --QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNY 558
+G + C S PT + WS+ LQ + R QG L++Q + ED G Y
Sbjct: 3901 AEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEY 3959
Query: 559 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYR 616
+C G+ + TL T P V + + V G A L CE S V W +
Sbjct: 3960 TCTC----GSQATSATLTVTAAP-VRFLRELQHQEVDEGGTAHLCCELSRA-GASVEWRK 4013
Query: 617 GGLEMILAP-----EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL 671
G L++ + ++ +L + ++ DAG YTC + AS +++ P+
Sbjct: 4014 GSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVP---RPKF 4070
Query: 672 TELPRDVTVELGRSALLACR-ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR-QPDSGV 729
+ + E G A L C+ + V W + G+ L AG R Q +
Sbjct: 4071 KTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKE-----GVELHAGPKYEMRSQGATRE 4125
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 789
L + +D Y C V G + A L VT I V + V C
Sbjct: 4126 LLIHQLEAKDTGEYAC----VTGGQKTAASLRVT-EPEVTIVRGLVDAEVTADEDVEFSC 4180
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSRHSIRA-DGSLH---LDRALQEHAGRYSCVATNTAG 845
V + W G PL + DG +H L E AG S N A
Sbjct: 4181 EVSRAGATGVQ-WCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHAS 4239
Query: 846 SQHRDVELVVQVP--PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
S +L V+ P + P + +EG AS C S W L +
Sbjct: 4240 S----AQLTVRAPEVTILEPLQDVQL-SEGQDASFQCRLSRASGQEARWALGGVPLQANE 4294
Query: 904 PHYNVSKEGT---LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
+ ++GT L + + + +DAG T + VG S E +L V K + + G N
Sbjct: 4295 MNDITVEQGTLHLLTLHKVTLEDAG----TVSFHVGTCSSEAQLKVTAKNTV-VRGLEN- 4348
Query: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997
V A G E +C+ TW D PV
Sbjct: 4349 -----VEALEGGEALFECQLSQPEVAAHTWLLDDEPV 4380
Score = 103 bits (257), Expect = 1e-21
Identities = 121/431 (28%), Positives = 162/431 (37%), Gaps = 71/431 (16%)
Query: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727
AP+ P+ V +G+ A L+C+ G P P V+W + D QP+ G+R R
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEK-DQQPV------AAGARFRLAQD 61
Query: 728 GVLF---FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA-----PPQIASSAPTVRV 779
G L+ +A D YVC ARN G+ A L V A P ++RV
Sbjct: 62 GDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRV 121
Query: 780 LEGQPVSLPCIVLAGRPLPERHWLKDGRPL--PPGSRHSIRADG---SLHLDRALQEHAG 834
EG + C V G P P W KDGR L P G R + G +L + A G
Sbjct: 122 REGSEATFRCRV-GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG 180
Query: 835 RYSCVATNTAGSQHRDVELVVQ--------------------------------VPPRIH 862
Y A N G+ LVV P
Sbjct: 181 TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP 240
Query: 863 PTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRGPH--YNVSKEGTLL-IAQ 918
T T T EG A L C +G P P W K+ +T H Y ++E +L I
Sbjct: 241 STGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILF 300
Query: 919 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC 978
D G Y CTA+N VG + + L V +P + + L+V K E T C
Sbjct: 301 CKQSDRGLYTCTASNLVGQTYSSV-LVVVREPAVPF---KKRLQDLEVREK--ESATFLC 354
Query: 979 EAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRLAQVQVGDSGHYECTASNPAGS 1035
E P W K+ + + +YG+ G+ L + V D Y C P GS
Sbjct: 355 EVP-QPSTEAAWFKEETRL-WASAKYGIEEEGTERRLTVRNVSADDDAVYIC--ETPEGS 410
Query: 1036 ASHRYVLGVQG 1046
+ L VQG
Sbjct: 411 RTVA-ELAVQG 420
Score = 95.9 bits (237), Expect = 2e-19
Identities = 166/678 (24%), Positives = 254/678 (37%), Gaps = 81/678 (11%)
Query: 390 AKAQIVVTDPPPQLV-PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST--GR 446
+KA ++V + P ++ P + V+PGE L C L A + W++D + + S
Sbjct: 2816 SKASLIVRERPAAIIKPLEDQWVAPGEDVELRCE-LSRAGTPVHWLKDRKAIRKSQKYDV 2874
Query: 447 VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH--TSSQHFSQ 504
V + L I G D G Y C ++++ L V E T+ Q +
Sbjct: 2875 VCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVEEKANCFTEELTNLQVEEK 2930
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 561
G V +C +P ++W + L+ + +G L I + D+ Y+C
Sbjct: 2931 GTAV-FTCKTE-HPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTC- 2987
Query: 562 ATNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGGL 619
++G Q L V + + V V G A C S V W+
Sbjct: 2988 ---DIGQAQSRAQL-LVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKT 3043
Query: 620 --------EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL 671
E+ P G LR A +D+GT E GD A L V P +
Sbjct: 3044 PLHANELNEIDAQPGGYHVLTLRQLAL--KDSGT----IYFEAGDQRASAALRVTEKPSV 3097
Query: 672 -TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
+ D T+ G L C + P V W + DG+ L G+ R S + L
Sbjct: 3098 FSRELTDATITEGEDLTLVCETSTCDIP-VCWTK-DGKTL---RGSARCQLSHEGHRAQL 3152
Query: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA-PPQIASSAPTVRVLEGQPVSLPC 789
+D Y CEA A + IV HA P + + + VLEG +L C
Sbjct: 3153 LITGATLQDSGRYKCEAGG------ACSSSIVRVHARPVRFQEALKDLEVLEGGAATLRC 3206
Query: 790 IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGS 846
VL+ P + W L PG ++S+R +G+ L + + +GRYSC + G
Sbjct: 3207 -VLSSVAAPVK-WCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGD 3260
Query: 847 QHRDVEL-VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905
Q L V +P + + EG A+L C S A + W K + L G
Sbjct: 3261 QTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLRD-GDR 3317
Query: 906 YNVSKEGT---LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Y + ++G L I + DA Y C G L++ P H G
Sbjct: 3318 YCLRQDGAMCELQIRGLAMVDAAEYSCVC----GEERTSASLTIRPMP-AHFIGRLRHQE 3372
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRLAQVQV 1019
++ G TL CE + P V W K + +R+ L G+ L++ + V
Sbjct: 3373 SIE-----GATATLRCELSKAAP--VEWRKGRESLRD-GDRHSLRQDGAVCELQICGLAV 3424
Query: 1020 GDSGHYECTASNPAGSAS 1037
D+G Y C SA+
Sbjct: 3425 ADAGEYSCVCGEERTSAT 3442
Score = 89.0 bits (219), Expect = 3e-17
Identities = 177/752 (23%), Positives = 267/752 (35%), Gaps = 111/752 (14%)
Query: 351 GEERHFQESGNSSWEILRASKAEEG-TYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV 409
G +E G +S +RA++ +G TYE A + G A A +VV P
Sbjct: 155 GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214
Query: 410 ---------------------------------TVSPGETAVLSCRVLGEAPYNLTWVRD 436
TV+ G+ A LSC V GE W +D
Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKD 274
Query: 437 WRVLPASTGRVAQ---LADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV 493
+++ V + L+I +D G Y C ASN G T +SV ++VRE P V
Sbjct: 275 GQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVRE-PAV 333
Query: 494 SIHTSSQHFSQGVEVKVSCSAS-----GYPTPHISWSRESQALQEDSRIHVDAQGT---L 545
+ Q +EV+ SA+ P+ +W +E L ++ ++ +GT L
Sbjct: 334 PF----KKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRL 389
Query: 546 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605
++ V+ +D Y C E TV + + V VG+ A + C
Sbjct: 390 TVRNVSADDDAVYIC----ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTA-MFCVEL 444
Query: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNEL-------GDAS 658
VP V W R E++ + G++ I A R T + + ++ GD
Sbjct: 445 AVPVGPVHWLRNQEEVV------AGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQ 498
Query: 659 AEIQLAVGHAPQLTEL--PRD--VTVELGRSALLACRAT--GRPPPTVTWRRGDGQPLGL 712
Q V AP+ L P D V + S +L+ G P T+ + + LG
Sbjct: 499 TSTQFCVS-APRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGT 557
Query: 713 RLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIAS 772
R + + L VA E + A N FG+ T H P++A
Sbjct: 558 YTWI-RCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPGTVHLAPKLAV 615
Query: 773 SAP--TVRVLEGQPVSLP---CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDR 827
P V+ +EG V+ + AG W DG+ L S + I D + H
Sbjct: 616 RTPLKAVQAVEGGEVTFSVDLTVASAG------EWFLDGQALKASSVYEIHCDRTRHTLT 669
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVAS---- 883
+ A + A + + V+ P + V A L A
Sbjct: 670 IREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAE 729
Query: 884 -GVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFSS 939
A +TW K+ L S GP Y V LL+ + DAG Y C +
Sbjct: 730 LSDQAAAVTWLKDGRTL-SPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRG----GR 784
Query: 940 QEMRLSVNTKPR-IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 998
+LSV R +H + + + V A AG +CE + V W KD +
Sbjct: 785 IAYQLSVQGLARFLHKDMAGSC-----VDAVAGGPAQFECETSEAHVH-VHWYKDGMELG 838
Query: 999 PITNRYGLLPSGS---LRLAQVQVGDSGHYEC 1027
R+ G+ L A V D G Y C
Sbjct: 839 HSGERFLQEDVGTRHRLVAATVTRQDEGTYSC 870
Score = 88.6 bits (218), Expect = 3e-17
Identities = 170/751 (22%), Positives = 266/751 (35%), Gaps = 96/751 (12%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAK------AQIVVTDPPPQLVPAP-NVTVSPGETAV 418
IL + + G Y C A + G A A+ + P + P ++ V G A
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 419 LSCRVLGEAPYNLTWVRDWRVLPASTG---RVAQLADLS-LEISGIIPTDGGRYQCVASN 474
CRV G ++W +D R L G RV +L + S L I P DGG Y+ A N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Query: 475 ANGVTRASVWLLV-------------------------REAPQV--------SIHTSSQH 501
G A+ L+V REA + S T +
Sbjct: 189 PLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCT 248
Query: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQGTLIIQGV--APEDAGN 557
++G ++SC +G P P W ++ Q + E R ++ DAQ +++ + D G
Sbjct: 249 VTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGL 308
Query: 558 YSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL-VAVGEEAVLVCEASGVPPPRVIWYR 616
Y+C A+N VG +V + +P L V E A +CE P W++
Sbjct: 309 YTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVP-QPSTEAAWFK 367
Query: 617 GGLEMILA-----PEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL 671
+ + E + +L + D Y C E + S + L
Sbjct: 368 EETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC----ETPEGSRTVAELAVQGNLL 423
Query: 672 TELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF 731
+LPR V +G +A+ C P V W R + + GR + S + L
Sbjct: 424 RKLPRKTAVRVGDTAMF-CVELAVPVGPVHWLRNQEEV----VAGGRVAISAEGTRHTLT 478
Query: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV 791
ED V + + G Q + V+ AP + P V++ + S +
Sbjct: 479 ISQCCLED----VGQVAFMAGDCQTSTQFCVS--APRKPPLQPPVDPVVKARMESSVILS 532
Query: 792 LAGRPLPERHWLKDGRPLPP---GSRHSIR-------ADGSLHLDRALQEHAGRYSCVAT 841
+ P ER DG + G+ IR A L + +E ++ A
Sbjct: 533 WSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSAL 592
Query: 842 NTAG-SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALT 900
N+ G S + + V + P++ + A W + AL
Sbjct: 593 NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQALK 652
Query: 901 SRGPH--YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSR 958
+ + + TL I + A GA + N + +R+ V P + N
Sbjct: 653 ASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGI---ESSIRMEVRAAPGLTAN-KP 708
Query: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLR---LA 1015
A +V A+ EE L E VTW KD R + P +Y + S R +
Sbjct: 709 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSP-GPKYEVQASAGRRVLLVR 766
Query: 1016 QVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046
V D+G YEC + Y L VQG
Sbjct: 767 DVARDDAGLYECVSR----GGRIAYQLSVQG 793
Score = 87.0 bits (214), Expect = 1e-16
Identities = 128/561 (22%), Positives = 191/561 (34%), Gaps = 111/561 (19%)
Query: 594 VGEEAVLVCEASGVPPPRVIWYRGGLEMI------LAPEGSSSGKLRIPAAQERDAGTYT 647
VG+ L C + R W + G+E+ + G + L I DAG YT
Sbjct: 4911 VGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYT 4970
Query: 648 CRAVNELGDASAEIQLAVG-------------------------HAPQLTELPRDVTVEL 682
C+ N+ G + + V H T+ P +V+ E
Sbjct: 4971 CQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSDE- 5029
Query: 683 GRSALLACRATGRPPPTVTWR--RGDGQPLGLRLGAGRGSRSRQPDSGVLFFE-----SV 735
L A P W+ R D + +R A +R +F +
Sbjct: 5030 -ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQEMFATLGIGVEI 5088
Query: 736 APEDQAPY---VCEARNVFGKVQAEARL--IVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
+Q P +C ++ V L ++T A P + V +G PVS C+
Sbjct: 5089 KLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCV 5148
Query: 791 VLAGRPLPERHWLKDGRPLPPGSRHSIRADGS----LHLDRALQEHAGRYSCVATNTAGS 846
V G+P+P W KDG+ L + I D L + + G Y C+A N+ G
Sbjct: 5149 V-TGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGV 5207
Query: 847 QHRDVELVVQVPPRIHPTA-----------------------THHITNEG-VP------- 875
EL V + + TA T T+EG +P
Sbjct: 5208 SSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELR 5267
Query: 876 ----------ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKE--GTLLIAQPSAQD 923
A G PAP + W K+ LT+ K+ TL I + +D
Sbjct: 5268 DLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTRED 5327
Query: 924 AGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNAN---VPLQVT-------AKAGEE 973
+G Y +N +G + RL V + + + VP ++ K G
Sbjct: 5328 SGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSS 5387
Query: 974 VTLDCEAKGSPPPLVTWTKDSRP-----VPPITNRYGLLPSG---SLRLAQVQVGDSGHY 1025
+T + +G P P V W ++ + P T Y + S SL L V G Y
Sbjct: 5388 ITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTY 5447
Query: 1026 ECTASNPAGSASHRYVLGVQG 1046
C ASN AG A L V G
Sbjct: 5448 TCIASNAAGQALCSASLHVSG 5468
Score = 85.9 bits (211), Expect = 2e-16
Identities = 174/726 (23%), Positives = 264/726 (36%), Gaps = 107/726 (14%)
Query: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV---PAPN-VTVSPGETAVLSC 421
+ A +A+ G Y C +AG R + V +P PA V G +A LSC
Sbjct: 1593 VQEAGQADAGEYSC----KAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSC 1648
Query: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVASNANGVT 479
V +A +TW +D + L +S+ + + L + D G Y C A G
Sbjct: 1649 EV-AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQ 1703
Query: 480 RASVWLLVREA-PQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQEDS 535
R S L V E PQ+S + + ++ ++ + + ++W ++ ++
Sbjct: 1704 RLSFRLHVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK 1763
Query: 536 RIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV 592
R +QG TL + G D+ YSC+ E G D + V+A +L
Sbjct: 1764 RHETASQGDTHTLTVHGAQVLDSAIYSCRVGAE-GQD------FPVQVEEVAAKFCRLLE 1816
Query: 593 AV----GEEAVLVCEASGVPPPRVIWYRG------GLEMILAPEGSSSGKLRIPAAQERD 642
V G L CE S V+W G G + EG L + + D
Sbjct: 1817 PVCGELGGTVTLACELSPACA-EVVWRCGNTQLRVGKRFQMVAEGPVRS-LTVLGLRAED 1874
Query: 643 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 702
AG Y C + ++ SA++ ++V + V E G A C + V +
Sbjct: 1875 AGEYVCESRDD--HTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWF 1932
Query: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
R G L + + + S+ S L + ED EA R
Sbjct: 1933 RDG-----ALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVR--- 1984
Query: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 822
AP V E V+L V RP PE W ++ L PG I A+G+
Sbjct: 1985 --EAPVLFKKKLEPQTVEERSSVTLE--VELTRPWPELRWTRNATALAPGKNVEIHAEGA 2040
Query: 823 LH---LDRALQEHAGRYSCVATNTAGSQHRDVEL--------VVQVPPRIHPTATHHI-- 869
H L G + C + VE+ + V R TAT +
Sbjct: 2041 RHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQL 2100
Query: 870 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGA 926
++ V S WT++ +GP +++ G TL ++ +D+G
Sbjct: 2101 SHADVDGS--------------WTRD-GLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGL 2145
Query: 927 YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ-VTAKAGEEVTLDCEAKGSPP 985
V A RL V P ++ SR PLQ V E+VTL+CE P
Sbjct: 2146 MVFKAEGV----HTSARLVVTELP---VSFSR----PLQDVVTTEKEKVTLECELS-RPN 2193
Query: 986 PLVTWTKDSRPVPPITNRYGLLPSG---SLRLAQVQVGDSGHYECTASNPAGSASHRYVL 1042
V W KD + + G SL + + + D G Y C A + SAS +
Sbjct: 2194 VDVRWLKDGVELRA-GKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSAS----V 2248
Query: 1043 GVQGRT 1048
VQGRT
Sbjct: 2249 KVQGRT 2254
Score = 83.6 bits (205), Expect = 1e-15
Identities = 60/214 (28%), Positives = 89/214 (41%), Gaps = 13/214 (6%)
Query: 651 VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 710
V E+ + L V P E D T ELG + LACR TG P P ++W + DG+ +
Sbjct: 5996 VKEICGIQQRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYK-DGKAV 6054
Query: 711 GLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 769
+ PD S L +S+ D Y+C A + G +++V PP+
Sbjct: 6055 QV---DPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV--QVPPR 6109
Query: 770 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS-----LH 824
+ +EG+ C + G P P+ W KDG L G++ ++ L
Sbjct: 6110 FVNKVRASPFVEGEDAQFTC-TIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLV 6168
Query: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
+ A +E G Y C N GS EL +Q P
Sbjct: 6169 IRAASKEDLGLYECELVNRLGSARASAELRIQSP 6202
Score = 80.9 bits (198), Expect = 7e-15
Identities = 171/704 (24%), Positives = 245/704 (34%), Gaps = 84/704 (11%)
Query: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNL 431
+E TY C A G + AQ V + +V +VTV A C +
Sbjct: 2355 DEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPP 2410
Query: 432 TWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN-----GVTRASVWLL 486
W+ VL A ++ LE G + R C G +R+S L+
Sbjct: 2411 KWLLGKTVLQAG-------GNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLV 2463
Query: 487 VREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 545
V + P V + ++ V +SC P + W ++ L + + +G +
Sbjct: 2464 VSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQM 2522
Query: 546 I---IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE--AVL 600
I + P DAG Y CQA + + + TV + V+ + EE A
Sbjct: 2523 AELRILRLMPADAGVYRCQAGSAHSSTEVTV-----EAREVTVTGPLQDAEATEEGWASF 2577
Query: 601 VCEASGVPPPRVIWYRGGLEMI--LAPEGSSSGK---LRIPAAQERDAGTYTCRAVNELG 655
CE S V W G+ + E S G+ L + + Q DAG RA +
Sbjct: 2578 SCELSH-EDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAG--IVRASSLKV 2634
Query: 656 DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG---- 711
SA +++ V L L D++ E + L C + P V WR+ DG LG
Sbjct: 2635 STSARLEVRVKPVVFLKALD-DLSAEERGTLALQCEVSD-PEAHVVWRK-DGVQLGPSDK 2691
Query: 712 ---LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
L RG L V+PED Y C G + AR+ V
Sbjct: 2692 YDFLHTAGTRG----------LVVHDVSPEDAGLYTCHV----GSEETRARVRV-HDLHV 2736
Query: 769 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA 828
I T+ VLEG+ S C++ W G+ + SR G ++
Sbjct: 2737 GITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVV 2796
Query: 829 LQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
+ V + G + +V + P I G L C S P
Sbjct: 2797 REAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP 2856
Query: 889 TITWTKETNALTSRGPHYNVSKEGT---LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLS 945
+ W K+ A+ + Y+V EGT L+I S +DAG Y C V S L
Sbjct: 2857 -VHWLKDRKAI-RKSQKYDVVCEGTMAMLVIRGASLKDAGEYTC----EVEASKSTASLH 2910
Query: 946 VNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYG 1005
V K N LQV K T E P VTW K +
Sbjct: 2911 VEEKANCFTEELTN----LQVEEKGTAVFTCKTE---HPAATVTWRKGLLELRASGKHQP 2963
Query: 1006 LLPSGSLRL--AQVQVGDSGHYECTASNPAGSASHRYVLGVQGR 1047
+LRL + ++ DS Y C G A R L VQGR
Sbjct: 2964 SQEGLTLRLTISALEKADSDTYTC----DIGQAQSRAQLLVQGR 3003
Score = 80.9 bits (198), Expect = 7e-15
Identities = 56/174 (32%), Positives = 79/174 (45%), Gaps = 15/174 (8%)
Query: 505 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-----DAQGTLIIQGVAPEDAGNYS 559
G VK++C +G P P ISW ++ +A+Q D H+ D LI+ + D+G Y
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPH-HILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 560 CQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
C A + G + PP V+ V A V GE+A C G P P++ WY+ G
Sbjct: 6087 CFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVE-GEDAQFTCTIEGAPYPQIRWYKDG 6145
Query: 619 LEMI-------LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
+ L+ S L I AA + D G Y C VN LG A A +L +
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 79.0 bits (193), Expect = 3e-14
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 82/334 (24%)
Query: 602 CEASGVPPPRVIWYRGGLEM------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 655
C +G P P V W++ G + ++ + +L I A D G Y C A N +G
Sbjct: 5147 CVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMG 5206
Query: 656 DASAEIQLAV----------------------------------------GHAPQLTELP 675
+S + +L V G PQ+ E
Sbjct: 5207 VSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEEL 5266
Query: 676 RDVTVELG-RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF--- 731
RD+ V G R A + G P P + W + DGQPL + R D +L
Sbjct: 5267 RDLQVAPGTRLAKFQLKVKGYPAPRLYWFK-DGQPLTA------SAHIRMTDKKILHTLE 5319
Query: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH---------------APPQIASSAPT 776
SV ED Y N G + ARL+V G PP++
Sbjct: 5320 IISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTP 5379
Query: 777 VRVLEGQPVSLPCIVLAGRPLPERHWLKD---------GRPLPPGSRHSIRADGSLHLDR 827
+V +G ++ + + GRP+P HWL++ G P + S SL L
Sbjct: 5380 KKVKKGSSITF-SVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLD 5438
Query: 828 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861
++H G Y+C+A+N AG L V P++
Sbjct: 5439 VGRQHQGTYTCIASNAAGQALCSASLHVSGLPKV 5472
Score = 76.3 bits (186), Expect = 2e-13
Identities = 60/198 (30%), Positives = 84/198 (42%), Gaps = 11/198 (5%)
Query: 757 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 816
+ RL + PP G+ V L C V G P P W KDG+ + H
Sbjct: 6003 QQRLALPVWRPPDFEEELADCTAELGETVKLACRV-TGTPKPVISWYKDGKAVQVDPHHI 6061
Query: 817 I--RADGS--LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNE 872
+ DGS L LD +G+Y C A + AG+ +++VQVPPR E
Sbjct: 6062 LIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVE 6121
Query: 873 GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT----LLIAQPSAQDAGAYV 928
G A C G P P I W K+ LT+ +S+ + L+I S +D G Y
Sbjct: 6122 GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYE 6181
Query: 929 CTATNTVGF--SSQEMRL 944
C N +G +S E+R+
Sbjct: 6182 CELVNRLGSARASAELRI 6199
Score = 75.1 bits (183), Expect = 4e-13
Identities = 138/624 (22%), Positives = 221/624 (35%), Gaps = 148/624 (23%)
Query: 414 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR---VAQLAD--LSLEISGIIPTDGGRY 468
G+ L C V +A W++D L + GR + QL D SL I+G+ D G Y
Sbjct: 4912 GDALRLECVVASKADVRARWLKDGVEL--TDGRHHHIDQLGDGTCSLLITGLDRADAGCY 4969
Query: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
C SN G S ++V S S S G E+ + + H + +S
Sbjct: 4970 TCQVSNKFGQVTHSACVVV------SGSESEAESSSGGELDDAFRRAARRL-HRLFRTKS 5022
Query: 529 QALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNE---------VGTDQETVTLYYT 578
A D + + A +G A PE+ ++ +E + ++ VT +
Sbjct: 5023 PAEVSDEELFLSAD-----EGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQE 5077
Query: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA 638
++ + LV G V +C + P P ++ PE +P+
Sbjct: 5078 MFATLGIGVEIKLVEQGPRRVEMCISKETPAP-----------VVPPEP-------LPSL 5119
Query: 639 QERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 698
DA LTEL ++ V+ G C TG+P P
Sbjct: 5120 LTSDAAPVF-----------------------LTEL-QNQEVQDGYPVSFDCVVTGQPMP 5155
Query: 699 TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG--KVQA 756
+V W + DG+ L Q L +V P D Y C A N G +A
Sbjct: 5156 SVRWFK-DGKLL--EEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKA 5212
Query: 757 EARLIVT--------------------GHAP----------------PQIASSAPTVRVL 780
E R+ +T G+ PQ+ ++V
Sbjct: 5213 ELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVA 5272
Query: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRAD----GSLHLDRALQEHAGRY 836
G ++ + + G P P +W KDG+PL S H D +L + +E +G+Y
Sbjct: 5273 PGTRLAKFQLKVKGYPAPRLYWFKDGQPL-TASAHIRMTDKKILHTLEIISVTREDSGQY 5331
Query: 837 SCVATNTAGSQHRDVELVVQ-----------------VPPRIHPTATHHITNEGVPASLP 879
+ +N G+ + L+V+ VPPR+ T +G +
Sbjct: 5332 AAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFS 5391
Query: 880 CVASGVPAPTITWTKETNALTSRG--------PHYNV---SKEGTLLIAQPSAQDAGAYV 928
G P PT+ W +E RG P Y V +++ +L++ Q G Y
Sbjct: 5392 VKVEGRPVPTVHWLREE---AERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYT 5448
Query: 929 CTATNTVGFSSQEMRLSVNTKPRI 952
C A+N G + L V+ P++
Sbjct: 5449 CIASNAAGQALCSASLHVSGLPKV 5472
Score = 73.9 bits (180), Expect = 8e-13
Identities = 64/310 (20%), Positives = 122/310 (39%), Gaps = 22/310 (7%)
Query: 292 GNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHS-------ALPFRLQLR 344
G P+ + + + G APGA + H +L + LV C + FR ++
Sbjct: 5894 GEPIRQGHFIVWEG-APGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMK 5952
Query: 345 RGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRA------KAQIVVTD 398
L ++ + W+ S + TA+ ++ + + + V
Sbjct: 5953 LSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWR 6012
Query: 399 PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---QLADLSL 455
PP + T GET L+CRV G ++W +D + + + +L
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 456 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 515
+ + D G+Y C A++A G +LV+ P+ + F +G + + +C+
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIE 6132
Query: 516 GYPTPHISWSRESQALQEDSRIHVDAQG-----TLIIQGVAPEDAGNYSCQATNEVGTDQ 570
G P P I W ++ L ++ ++ L+I+ + ED G Y C+ N +G+ +
Sbjct: 6133 GAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSAR 6192
Query: 571 ETVTLYYTDP 580
+ L P
Sbjct: 6193 ASAELRIQSP 6202
Score = 73.2 bits (178), Expect = 1e-12
Identities = 128/541 (23%), Positives = 205/541 (37%), Gaps = 70/541 (12%)
Query: 341 LQLRRGEARLGEERHFQ--ESGNSSWEILRASKAEE-GTYECTAVSRAGTGRAKAQIVVT 397
++ R+G +L +Q + G ++ ++R + E+ G Y C G ++ A + V
Sbjct: 4009 VEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDT----GHTQSMASLSVR 4064
Query: 398 DPPPQL-VPAPNVTVSPGETAVLSCRVL-GEAPYNLTWVRDWRVLPASTGRV--AQLADL 453
P P+ ++ G+ A L C++ E+ + W+++ L A +Q A
Sbjct: 4065 VPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATR 4124
Query: 454 SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS--SQHFSQGVEVKVS 511
L I + D G Y CV G + + L V E P+V+I + +V+ S
Sbjct: 4125 ELLIHQLEAKDTGEYACVT----GGQKTAASLRVTE-PEVTIVRGLVDAEVTADEDVEFS 4179
Query: 512 CSASGYPTPHISWSRESQALQE---------DSRIHVDAQGTLIIQGVAPEDAGNYSCQA 562
C S + W + LQ D RIH TL ++GV PEDAG S
Sbjct: 4180 CEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIH-----TLRLKGVTPEDAGTVSFHL 4234
Query: 563 TNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 620
N + Q TV P V+ + + V ++ G++A C S W GG+
Sbjct: 4235 GNHASSAQLTVR-----APEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVP 4289
Query: 621 M------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL 674
+ + E + L + DAGT + +G S+E QL V +
Sbjct: 4290 LQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSF----HVGTCSSEAQLKVTAKNTVVRG 4345
Query: 675 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA-----GRGSRSRQPDSGV 729
+V G AL C+ + TW D +P+ A G R +
Sbjct: 4346 LENVEALEGGEALFECQLSQPEVAAHTWLL-DDEPVHTSENAEVVFFENGLRH------L 4398
Query: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 789
L +++ P+D C + G + A L V G +I V G C
Sbjct: 4399 LLLKNLRPQDS----CRVTFLAGDMVTSAFLTVRGWR-LEILEPLKNAAVRAGAQACFTC 4453
Query: 790 IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLH---LDRALQEHAGRYSCVATNTAG 845
+ P+ E W +G + P S ++ ADGS H L A HAG + +
Sbjct: 4454 TLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVA 4513
Query: 846 S 846
S
Sbjct: 4514 S 4514
Score = 67.0 bits (162), Expect = 1e-10
Identities = 54/199 (27%), Positives = 77/199 (38%), Gaps = 12/199 (6%)
Query: 570 QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM------IL 623
Q+ + L PP A +GE L C +G P P + WY+ G + IL
Sbjct: 6003 QQRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHIL 6062
Query: 624 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELG 683
+ S L + + D+G Y C A + G+ S ++ V P+ R G
Sbjct: 6063 IEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEG 6122
Query: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG--VLFFESVAPEDQA 741
A C G P P + W + DG L + +P SG VL + + ED
Sbjct: 6123 EDAQFTCTIEGAPYPQIRWYK-DG---ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLG 6178
Query: 742 PYVCEARNVFGKVQAEARL 760
Y CE N G +A A L
Sbjct: 6179 LYECELVNRLGSARASAEL 6197
Score = 66.6 bits (161), Expect = 1e-10
Identities = 77/349 (22%), Positives = 122/349 (34%), Gaps = 75/349 (21%)
Query: 400 PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---QLADLSLE 456
P L N V G C V G+ ++ W +D ++L + Q L
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI 5185
Query: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLV----------REAPQVSIHTSSQHF---- 502
I+ ++P D G Y+C+A N+ GV+ L V +A + S + S+Q +
Sbjct: 5186 ITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSR 5245
Query: 503 -SQGVE--------------------------VKVSCSASGYPTPHISWSRESQALQEDS 535
+G E K GYP P + W ++ Q L +
Sbjct: 5246 EQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASA 5305
Query: 536 RIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS-----VSAVN 587
I + + TL I V ED+G Y+ +N +G + L P S V+
Sbjct: 5306 HIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVH 5365
Query: 588 AVVL------------VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRI 635
++ V G + G P P V W R E + G + +
Sbjct: 5366 EQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTV 5425
Query: 636 PAAQERDA-----------GTYTCRAVNELGDASAEIQLAVGHAPQLTE 673
++ ++ + GTYTC A N G A L V P++ E
Sbjct: 5426 ASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEE 5474
Score = 62.8 bits (151), Expect = 2e-09
Identities = 178/748 (23%), Positives = 266/748 (35%), Gaps = 130/748 (17%)
Query: 382 VSRAGTGRAKAQIVVTDPPPQLV-PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL 440
V +A A++VVT+ P P +V + E L C L ++ W++D L
Sbjct: 2147 VFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECE-LSRPNVDVRWLKDGVEL 2205
Query: 441 PA--STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW----------LLVR 488
A + AQ A SL I D G Y C A +A V +L
Sbjct: 2206 RAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAE 2265
Query: 489 EAPQVSIHTSSQHFSQGVEVK----------------------VSCSASGYPTPHISWSR 526
+A ++ + + VK + C S + + W +
Sbjct: 2266 DAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSR-ASAQVRWFK 2324
Query: 527 ESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 583
SQ LQ + + + G LII V ED Y+C A D +T ++ + S+
Sbjct: 2325 GSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDA-----GDVKTSAQFFVEEQSI 2379
Query: 584 SAVNAVVLVAVGEEAV--LVCEAS--GVPPPRVIWYRG------GLEMILAPEGSSSGKL 633
+ V + V V E A CE S V PP+ W G G + L EG+ +
Sbjct: 2380 TIVRGLQDVTVMEPAPAWFECETSIPSVRPPK--WLLGKTVLQAGGNVGLEQEGTVHRLM 2437
Query: 634 RIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR---SALLAC 690
R T T +G + + +L V P + L R + + GR S +L+C
Sbjct: 2438 -----LRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVV--LTRPLEPKTGRELQSVVLSC 2490
Query: 691 RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 750
RP P D PL + + S + L + P D Y C+A +
Sbjct: 2491 --DFRPAPKAVQWYKDDTPLS---PSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSA 2545
Query: 751 FG--KVQAEAR-LIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR 807
+V EAR + VTG P Q A + E S C + E W +G
Sbjct: 2546 HSSTEVTVEAREVTVTG--PLQDAEAT------EEGWASFSCEL--SHEDEEVEWSLNGM 2595
Query: 808 PLPPGSRHSIRADGSLH---LDRALQEHAG--RYSCVATNTAGSQHRDVELVVQVPPRIH 862
PL S H I G H L + AG R S + +T+ L V+V P +
Sbjct: 2596 PLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTS------ARLEVRVKPVVF 2649
Query: 863 PTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT--LLIAQP 919
A ++ E +L C S P + W K+ L + + GT L++
Sbjct: 2650 LKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDV 2708
Query: 920 SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC- 978
S +DAG Y C VG R+ V+ +H+ ++ + GE + +C
Sbjct: 2709 SPEDAGLYTC----HVGSEETRARVRVHD---LHVGITKRLKT---MEVLEGESCSFECV 2758
Query: 979 --EAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
S P + WT + V S R + G Y A S
Sbjct: 2759 LSHESASDPAM--WTVGGKTV-----------GSSSRFQATRQGRK--YILVVREAAPSD 2803
Query: 1037 SHRYVLGVQGRTSWQPQSLPVPHHPACL 1064
+ V V+G TS SL V PA +
Sbjct: 2804 AGEVVFSVRGLTS--KASLIVRERPAAI 2829
Score = 60.1 bits (144), Expect = 1e-08
Identities = 88/373 (23%), Positives = 133/373 (35%), Gaps = 62/373 (16%)
Query: 845 GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
G Q R + L V PP G L C +G P P I+W K+ A+ P
Sbjct: 6001 GIQQR-LALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQV-DP 6058
Query: 905 HYNVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
H+ + ++ L++ + D+G Y+C A + G S ++ V PR
Sbjct: 6059 HHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRF-------V 6111
Query: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL--PSGSLRLAQVQ 1018
N GE+ C +G+P P + W KD + N++ L P L + ++
Sbjct: 6112 NKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG-ALLTTGNKFQTLSEPRSGLLVLVIR 6170
Query: 1019 VG---DSGHYECTASNPAGSASHRYVLGVQ----------------GRTSWQPQSLPVPH 1059
D G YEC N GSA L +Q Q VP
Sbjct: 6171 AASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQETKVPK 6230
Query: 1060 HPACLSGLSVPLLQPTPRSVRLCHLSLRAPLPPPFATPTSC----LSQACLSSSTLSLHL 1115
+ ++ + +PR R R+P P +P+ C L L+ L L
Sbjct: 6231 KTVIIEE-TITTVVKSPRGQR------RSPSKSPSRSPSRCSASPLRPGLLAPDLLYLPG 6283
Query: 1116 SPYPLRGPGDAVQRP--PT---TQGRAQWGPGFGRTG-----------VRGEPMKVGLRG 1159
+ P R + Q+P PT T+ A G +G + K+G +G
Sbjct: 6284 AGQPRRPEAEPGQKPVVPTLYVTEAEAHSPALPGLSGPQPKWVEVEETIEVRVKKMGPQG 6343
Query: 1160 SLPGTRGPAGSPG 1172
P T P S G
Sbjct: 6344 VSPTTEVPRSSSG 6356
Score = 53.9 bits (128), Expect = 9e-07
Identities = 39/121 (32%), Positives = 52/121 (42%), Gaps = 17/121 (14%)
Query: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS---LRLAQVQV 1019
P G++ TL C+ G+P P V+W KD +PV R+ L G L + + +
Sbjct: 16 PKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV-AAGARFRLAQDGDLYRLTILDLAL 74
Query: 1020 GDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSV 1079
GDSG Y C A N G A L V + Q+ PH LL+PT V
Sbjct: 75 GDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQA---PHF----------LLRPTSIRV 121
Query: 1080 R 1080
R
Sbjct: 122 R 122
Score = 51.6 bits (122), Expect = 4e-06
Identities = 172/763 (22%), Positives = 268/763 (35%), Gaps = 121/763 (15%)
Query: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEILRASKAEEGTYECTA 381
Q +++SC A P +Q + + L F+ E + ILR A+ G Y C A
Sbjct: 2484 QSVVLSCDFRPA-PKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 441
G A + VT V A VTV+ G G A ++ + +
Sbjct: 2543 ------GSAHSSTEVT------VEAREVTVT-GPLQDAEATEEGWASFSCELSHEDEEVE 2589
Query: 442 ASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN----GVTRASVWLLVREAPQVSIHT 497
S + D EIS G R+ V + G+ RAS L V + ++ +
Sbjct: 2590 WSLNGMPLYNDSFHEISH----KGRRHTLVLKSIQRADAGIVRASS-LKVSTSARLEVRV 2644
Query: 498 SSQHFSQGVE---------VKVSCSASGYPTPHISWSRESQALQEDSR---IHVDAQGTL 545
F + ++ + + C S P H+ W ++ L + +H L
Sbjct: 2645 KPVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTAGTRGL 2703
Query: 546 IIQGVAPEDAGNYSCQATNEVGTDQETV-TLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA 604
++ V+PEDAG Y+C +E + V L+ + + + + E VL E+
Sbjct: 2704 VVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHES 2763
Query: 605 SGVPPPRVIWYRGGLEMILAPEGSSS-------GK---LRIPAAQERDAGTYTCRAVNEL 654
+ P +W GG + GSSS G+ L + A DAG V +
Sbjct: 2764 ASDP---AMWTVGGKTV-----GSSSRFQATRQGRKYILVVREAAPSDAG----EVVFSV 2811
Query: 655 GDASAEIQLAVGHAPQLTELP-RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713
+++ L V P P D V G L C + P V W + D + +
Sbjct: 2812 RGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLK-DRKAI--- 2866
Query: 714 LGAGRGSRSRQPD------SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 767
+S++ D +L + +D Y CE ++ A L V A
Sbjct: 2867 ------RKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVEEKA- 2915
Query: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG-SLHLD 826
++V E C P W K L +H +G +L L
Sbjct: 2916 NCFTEELTNLQVEEKGTAVFTC--KTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLT 2973
Query: 827 RALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH--PTATHHITNEGVPASLPCVASG 884
+ E A S T G +L+VQ R+H EG A+ C S
Sbjct: 2974 ISALEKAD--SDTYTCDIGQAQSRAQLLVQ-GRRVHIIEDLEDVDVQEGSSATFRCRISP 3030
Query: 885 VPAPTITW--------TKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 936
+ W E N + ++ Y+V L + Q + +D+G A G
Sbjct: 3031 ANYEPVHWFLDKTPLHANELNEIDAQPGGYHV-----LTLRQLALKDSGTIYFEA----G 3081
Query: 937 FSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRP 996
L V KP + +A T GE++TL CE P V WTKD +
Sbjct: 3082 DQRASAALRVTEKPSVFSRELTDA------TITEGEDLTLVCETSTCDIP-VCWTKDGKT 3134
Query: 997 VPPITNRYGLLPSG---SLRLAQVQVGDSGHYECTASNPAGSA 1036
+ + R L G L + + DSG Y+C A S+
Sbjct: 3135 LRG-SARCQLSHEGHRAQLLITGATLQDSGRYKCEAGGACSSS 3176
Score = 37.4 bits (85), Expect = 0.088
Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 488 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---- 543
+E P S G +++ C + W ++ L + H+D G
Sbjct: 4895 QEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTC 4954
Query: 544 TLIIQGVAPEDAGNYSCQATNEVG 567
+L+I G+ DAG Y+CQ +N+ G
Sbjct: 4955 SLLITGLDRADAGCYTCQVSNKFG 4978
Score = 35.0 bits (79), Expect = 0.43
Identities = 40/155 (25%), Positives = 62/155 (40%), Gaps = 27/155 (17%)
Query: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP-PPQLVPAPNV-------------- 409
EI+ ++ + G Y + G + A+++V P P+ PA +V
Sbjct: 5319 EIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFT 5378
Query: 410 --TVSPGETAVLSCRVLGEAPYNLTWVRD-------WRVLPASTG-RVAQLADL-SLEIS 458
V G + S +V G + W+R+ W + P + G VA A SL +
Sbjct: 5379 PKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLW-IGPDTPGYTVASSAQQHSLVLL 5437
Query: 459 GIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV 493
+ G Y C+ASNA G S L V P+V
Sbjct: 5438 DVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKV 5472
Score = 33.1 bits (74), Expect = 1.7
Identities = 88/435 (20%), Positives = 145/435 (33%), Gaps = 67/435 (15%)
Query: 377 YECTAVSRAGTGRA---KAQIVVTDPPPQLVPAPNVT----VSPGETAVLSCRVLGEAPY 429
+ AV G G + + +PP + P P+ V+ GE L V+ EA
Sbjct: 4594 FRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVAEAG- 4652
Query: 430 NLTWVRDW-RVLPASTGRV-AQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 487
+ W + R+ P V +Q L I G D G Y C G+ + S+
Sbjct: 4653 EVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHC------GLAQGSI---C 4703
Query: 488 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLII 547
A + S + + + A+ H+ W +AL R+ + TL
Sbjct: 4704 PAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLW----EALARKRRM--SREPTLDS 4757
Query: 548 QGVAPEDAGNYSC--QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605
PE+ G Q EV D ++ Y+ ++ L + + S
Sbjct: 4758 ISELPEEDGRSQRLPQEAEEVAPD---LSEGYSTADELARTGDADLSHTSSD-----DES 4809
Query: 606 GVPPPRVIWY-----RGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCR----AVNELGD 656
P ++ Y R G + + G+ + P Q+ + +LGD
Sbjct: 4810 RAGTPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDLGD 4869
Query: 657 -----ASAEIQLAVG-----------HAPQLTELPRDVTVELGRSALLACRATGRPPPTV 700
A+ +IQ A P + D ++G + L C +
Sbjct: 4870 PSMDKAAVKIQAAFKGYKVRKEMKQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRA 4929
Query: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGV--LFFESVAPEDQAPYVCEARNVFGKVQAEA 758
W + G+ L GR Q G L + D Y C+ N FG+V A
Sbjct: 4930 RWLKD-----GVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSA 4984
Query: 759 RLIVTGHAPPQIASS 773
++V+G +SS
Sbjct: 4985 CVVVSGSESEAESSS 4999
Score = 30.8 bits (68), Expect = 8.2
Identities = 41/192 (21%), Positives = 70/192 (36%), Gaps = 17/192 (8%)
Query: 863 PTATHHITNEGVPASLPCVAS-GVPA-PTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
P+ ++ G P + P + G PA P++ ++ L + P + T + PS
Sbjct: 4814 PSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPP--LGDLSTKDLGDPS 4871
Query: 921 AQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
A + A F ++R K G ++ A+ G+ + L+C
Sbjct: 4872 MDKAAVKIQAA-----FKGYKVR-----KEMKQQEGPMFSHTFGDTEAQVGDALRLECVV 4921
Query: 981 KGSPPPLVTWTKDSRPVPPITNRY-GLLPSG--SLRLAQVQVGDSGHYECTASNPAGSAS 1037
W KD + + + L G SL + + D+G Y C SN G +
Sbjct: 4922 ASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVT 4981
Query: 1038 HRYVLGVQGRTS 1049
H + V G S
Sbjct: 4982 HSACVVVSGSES 4993
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,083,498
Number of Sequences: 37866
Number of extensions: 3314282
Number of successful extensions: 28008
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 465
Number of HSP's that attempted gapping in prelim test: 11429
Number of HSP's gapped (non-prelim): 7078
length of query: 1215
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1101
effective length of database: 13,930,794
effective search space: 15337804194
effective search space used: 15337804194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.