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Search of human proteins with 119372317
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119372317 xin actin-binding repeat containing 2 isoform 1
[Homo sapiens]
(3549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119372317 xin actin-binding repeat containing 2 isoform 1 [Ho... 7041 0.0
gi|119372315 xin actin-binding repeat containing 2 isoform 2 [Ho... 783 0.0
gi|40255272 xin actin-binding repeat containing 1 [Homo sapiens] 417 e-116
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 70 5e-11
gi|38044112 restin isoform b [Homo sapiens] 64 3e-09
gi|4506751 restin isoform a [Homo sapiens] 64 3e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 64 3e-09
gi|71061468 centromere protein E [Homo sapiens] 64 3e-09
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 62 1e-08
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 62 1e-08
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 60 3e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 60 3e-08
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 60 4e-08
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 60 5e-08
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 59 9e-08
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 59 9e-08
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 59 9e-08
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 59 9e-08
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 59 9e-08
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 59 9e-08
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 59 9e-08
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 59 9e-08
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 59 9e-08
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 58 2e-07
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 58 2e-07
gi|47132519 Ras association and pleckstrin homology domains 1 is... 57 3e-07
gi|150170670 piccolo isoform 2 [Homo sapiens] 56 6e-07
gi|150378539 piccolo isoform 1 [Homo sapiens] 56 6e-07
gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens] 56 6e-07
gi|146134388 YLP motif containing 1 [Homo sapiens] 56 6e-07
>gi|119372317 xin actin-binding repeat containing 2 isoform 1 [Homo
sapiens]
Length = 3549
Score = 7041 bits (18267), Expect = 0.0
Identities = 3549/3549 (100%), Positives = 3549/3549 (100%)
Query: 1 MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT 60
MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT
Sbjct: 1 MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT 60
Query: 61 SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV 120
SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV
Sbjct: 61 SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV 120
Query: 121 FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES 180
FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES
Sbjct: 121 FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES 180
Query: 181 GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA 240
GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA
Sbjct: 181 GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA 240
Query: 241 NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS
Sbjct: 241 NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
Query: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV
Sbjct: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
Query: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQR 420
STKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQR
Sbjct: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQR 420
Query: 421 KETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPR 480
KETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPR
Sbjct: 421 KETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPR 480
Query: 481 RLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQ 540
RLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQ
Sbjct: 481 RLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQ 540
Query: 541 QARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDIS 600
QARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDIS
Sbjct: 541 QARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDIS 600
Query: 601 RGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFET 660
RGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFET
Sbjct: 601 RGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFET 660
Query: 661 RPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRS 720
RPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRS
Sbjct: 661 RPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRS 720
Query: 721 ELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLD 780
ELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLD
Sbjct: 721 ELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLD 780
Query: 781 TINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSR 840
TINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSR
Sbjct: 781 TINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSR 840
Query: 841 KCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKIT 900
KCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKIT
Sbjct: 841 KCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKIT 900
Query: 901 ASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKF 960
ASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKF
Sbjct: 901 ASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKF 960
Query: 961 DASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWL 1020
DASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWL
Sbjct: 961 DASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWL 1020
Query: 1021 FETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKT 1080
FETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKT
Sbjct: 1021 FETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKT 1080
Query: 1081 EQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIK 1140
EQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIK
Sbjct: 1081 EQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIK 1140
Query: 1141 DDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSM 1200
DDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSM
Sbjct: 1141 DDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSM 1200
Query: 1201 RYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDEC 1260
RYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDEC
Sbjct: 1201 RYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDEC 1260
Query: 1261 VKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQP 1320
VKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQP
Sbjct: 1261 VKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQP 1320
Query: 1321 LYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQ 1380
LYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQ
Sbjct: 1321 LYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQ 1380
Query: 1381 KGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVS 1440
KGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVS
Sbjct: 1381 KGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVS 1440
Query: 1441 VNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFD 1500
VNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFD
Sbjct: 1441 VNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFD 1500
Query: 1501 SIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLY 1560
SIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLY
Sbjct: 1501 SIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLY 1560
Query: 1561 SQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTE 1620
SQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTE
Sbjct: 1561 SQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTE 1620
Query: 1621 REILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQ 1680
REILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQ
Sbjct: 1621 REILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQ 1680
Query: 1681 EDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASER 1740
EDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASER
Sbjct: 1681 EDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASER 1740
Query: 1741 GNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVE 1800
GNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVE
Sbjct: 1741 GNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVE 1800
Query: 1801 RTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKT 1860
RTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKT
Sbjct: 1801 RTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKT 1860
Query: 1861 EEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKD 1920
EEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKD
Sbjct: 1861 EEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKD 1920
Query: 1921 DLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPK 1980
DLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPK
Sbjct: 1921 DLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPK 1980
Query: 1981 PGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALE 2040
PGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALE
Sbjct: 1981 PGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALE 2040
Query: 2041 KSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDR 2100
KSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDR
Sbjct: 2041 KSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDR 2100
Query: 2101 AVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSK 2160
AVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSK
Sbjct: 2101 AVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSK 2160
Query: 2161 PSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTS 2220
PSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTS
Sbjct: 2161 PSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTS 2220
Query: 2221 NVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPEN 2280
NVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPEN
Sbjct: 2221 NVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPEN 2280
Query: 2281 NVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFES 2340
NVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFES
Sbjct: 2281 NVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFES 2340
Query: 2341 FPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKE 2400
FPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKE
Sbjct: 2341 FPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKE 2400
Query: 2401 ASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTS 2460
ASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTS
Sbjct: 2401 ASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTS 2460
Query: 2461 KDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIK 2520
KDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIK
Sbjct: 2461 KDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIK 2520
Query: 2521 SHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHI 2580
SHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHI
Sbjct: 2521 SHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHI 2580
Query: 2581 TEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAK 2640
TEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAK
Sbjct: 2581 TEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAK 2640
Query: 2641 RLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQ 2700
RLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQ
Sbjct: 2641 RLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQ 2700
Query: 2701 SKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTEC 2760
SKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTEC
Sbjct: 2701 SKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTEC 2760
Query: 2761 SHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEE 2820
SHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEE
Sbjct: 2761 SHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEE 2820
Query: 2821 KNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESK 2880
KNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESK
Sbjct: 2821 KNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESK 2880
Query: 2881 AEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKG 2940
AEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKG
Sbjct: 2881 AEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKG 2940
Query: 2941 ALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIA 3000
ALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIA
Sbjct: 2941 ALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIA 3000
Query: 3001 MENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVH 3060
MENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVH
Sbjct: 3001 MENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVH 3060
Query: 3061 VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPS 3120
VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPS
Sbjct: 3061 VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPS 3120
Query: 3121 PTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSE 3180
PTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSE
Sbjct: 3121 PTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSE 3180
Query: 3181 QLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITI 3240
QLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITI
Sbjct: 3181 QLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITI 3240
Query: 3241 PVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVA 3300
PVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVA
Sbjct: 3241 PVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVA 3300
Query: 3301 VPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGET 3360
VPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGET
Sbjct: 3301 VPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGET 3360
Query: 3361 NHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFS 3420
NHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFS
Sbjct: 3361 NHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFS 3420
Query: 3421 GMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNF 3480
GMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNF
Sbjct: 3421 GMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNF 3480
Query: 3481 QKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGV 3540
QKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGV
Sbjct: 3481 QKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGV 3540
Query: 3541 PSGRQAEFS 3549
PSGRQAEFS
Sbjct: 3541 PSGRQAEFS 3549
>gi|119372315 xin actin-binding repeat containing 2 isoform 2 [Homo
sapiens]
Length = 938
Score = 783 bits (2022), Expect = 0.0
Identities = 392/392 (100%), Positives = 392/392 (100%)
Query: 1 MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT 60
MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT
Sbjct: 1 MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPT 60
Query: 61 SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV 120
SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV
Sbjct: 61 SLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSV 120
Query: 121 FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES 180
FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES
Sbjct: 121 FEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPES 180
Query: 181 GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA 240
GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA
Sbjct: 181 GHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSA 240
Query: 241 NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS
Sbjct: 241 NMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
Query: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV
Sbjct: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
Query: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIK 392
STKLLKEQFEKSAQEKILYSDKEMTTPAKQIK
Sbjct: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIK 392
>gi|40255272 xin actin-binding repeat containing 1 [Homo sapiens]
Length = 1843
Score = 417 bits (1073), Expect = e-116
Identities = 280/846 (33%), Positives = 446/846 (52%), Gaps = 124/846 (14%)
Query: 434 TSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSK-- 491
T + +A E+ P PPP L+ +LP PP PK+ +SK
Sbjct: 4 TQTQVAPTPTMRMATAEDLPLPPPPALE------------DLPLPP-----PKESFSKFH 46
Query: 492 -QRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTN 550
QR EL RLY+HIHPELRKNL + +++E++ S+
Sbjct: 47 QQRQASELRRLYRHIHPELRKNLAEAVAEDLAEVLGSE---------------------- 84
Query: 551 DSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIA 610
E +G+VQ +RWIFEN LD+I G+ R A + ++
Sbjct: 85 -----------------EPTEGDVQCMRWIFENWRLDAI-------GEHERPAAKEPVLC 120
Query: 611 GGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMH 670
G DV+ T+ FE G++++ T + + P+ GDV ARW+FET+PLD +
Sbjct: 121 G-DVQATSRKFEE------GSFANSTDQEPTR-PQPGGGDVRAARWLFETKPLDELTGQA 172
Query: 671 QSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVK 730
+ E T+ + GDV+ R +FET+ LD+LG S+ E L+LRSE++E+KG+VK
Sbjct: 173 KELE---ATVREPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVK 229
Query: 731 RSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIK 790
+++K F+T+PL I+D G + E+K RE+++ VR+ARW+FET+PLD IN+D ++++
Sbjct: 230 KTVKLFQTEPLCAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVR 289
Query: 791 VVRGISMEENVKGGVSKAKWLFETQPLEKIKE---SEEVIIEKEKII--GTDVSRKCWMF 845
V+RGIS+EE + VS +W+FETQPL+ I+E E+ +I G DV ++ +F
Sbjct: 290 VIRGISLEEGARPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLF 349
Query: 846 ETQPLDILK--EVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASE 903
ET+ LD LK E A++ +EE++ GDV++T LFET P++A +D +G LQ++ +
Sbjct: 350 ETRALDTLKGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQD 409
Query: 904 EEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDAS 963
E L ++++ + +GDVK + ++FE+ L
Sbjct: 410 GE-------------GHLSSDSSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQG 456
Query: 964 HKIEVEGVTR--GAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLF 1021
+ +R G ++ +P+YA+QD G+ H + +V +E+IV GDV+ RW+F
Sbjct: 457 EVLAHGSPSREEGTDSAGQAQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMF 516
Query: 1022 ETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSI--KYFSDVEETESK 1079
ET+P+DQ S ++RGI+ QE+ G+V +A+WLFETQPL+ I + + ++ E K
Sbjct: 517 ETQPLDQLGRSPSTIDVVRGITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGK 576
Query: 1080 TE---QTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPL 1136
++ Q KGDV+T +WLFET PM L EK ++ K + ++CTW+F+ QP+
Sbjct: 577 SQGDPQPEAPPKGDVQTIRWLFETCPMSELAEKQG-SEVTDPTAKAEAQSCTWMFKPQPV 635
Query: 1137 DTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPV----EMDI 1192
D E Q ++ ++ G+ +T +FETE L + G +PV ++I
Sbjct: 636 DRPVGSRE-----QHLQVSQVPAGERQTDRHVFETEPLQA-SGRPCGR-RPVRYCSRVEI 688
Query: 1193 QAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKI- 1251
+G VS + F Q+L++ +E + I G+V WLFEN P+ +
Sbjct: 689 PSGQVSRQKEVF--QALEAGKKEEQE-----PRVIAGSIPAGSVHKFTWLFENCPMGSLA 741
Query: 1252 KESQEG 1257
ES +G
Sbjct: 742 AESIQG 747
Score = 286 bits (732), Expect = 3e-76
Identities = 273/1009 (27%), Positives = 443/1009 (43%), Gaps = 194/1009 (19%)
Query: 818 EKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKH 877
E + E ++ E+ DV W+FE LD + E +E ++ GDVQ T
Sbjct: 71 EAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGE--HERPAAKEPVLCGDVQATSR 128
Query: 878 LFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKL 937
FE + +S D Q+ T + GDVR +W+FET+PL+++ KE TV+
Sbjct: 129 KFEE---GSFANSTD----QEPTRPQPGGGDVRAARWLFETKPLDELTGQAKELEATVR- 180
Query: 938 EEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVT---------RGAVELNKSLFETTPL 988
E GDV+ +FE+ L + + ++ + +G V+ LF+T PL
Sbjct: 181 EPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPL 240
Query: 989 YAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQ 1048
AIQD G H+VK +EEI VRS RWLFETRP+D ++ + ++IRGIS +E
Sbjct: 241 CAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVRVIRGISLEEGA 300
Query: 1049 TGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVK--GDVKTCKWLFETQPMESL 1106
+V + +W+FETQPLD+I+ ++ E + + D++ DV+ + LFET+ +++L
Sbjct: 301 RPDVSATRWIFETQPLDAIR---EILVDEKDFQPSPDLIPPGPDVQQQQHLFETRALDTL 357
Query: 1107 ---YEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKD---------------------D 1142
E + EE+ GDV++ WLFET+PLD +D D
Sbjct: 358 KGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQDGEGHLSSD 417
Query: 1143 SETAVKL-QTVKQEEIQGGDVRTACFLFETENLDSI-QGEEVKEIKP-----VEMDIQAG 1195
S +A+ Q+ Q + GDV+T LFET LDSI QGE + P + QA
Sbjct: 418 SSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQGEVLAHGSPSREEGTDSAGQAQ 477
Query: 1196 DVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQ 1255
+ S Y ++ S+ L + ++ E I G+V RW+FE QP+D++ S
Sbjct: 478 GIGSPVYAMQD---------SKGRLHALTSVSREQIVGGDVQGYRWMFETQPLDQLGRSP 528
Query: 1256 EGDECVKTVT--DIQGGDVRKGCFIFETFSLDEI-------KEESDYISTKKTITEEVIQ 1306
+ V+ +T ++ GDV ++FET L+ I +++ + S E +
Sbjct: 529 STIDVVRGITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGKSQGDPQPEAPPK 588
Query: 1307 GDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSE 1366
GDV++ R LFET P+ + +++GS EVT + + + W+F+ +P+D S
Sbjct: 589 GDVQTIRWLFETCPMSELAEKQGS--EVT----DPTAKAEAQSCTWMFKPQPVDRPVGSR 642
Query: 1367 TVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMP----SIDHIQGGNVKTSR 1422
++ S + G+ + R+ FET+PL Q S P S I G V +
Sbjct: 643 EQHLQVS----QVPAGERQTDRHVFETEPL-QASGRPCGRRPVRYCSRVEIPSGQVSRQK 697
Query: 1423 QFFES-ENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQED 1481
+ F++ E K V I G+V TWLFE M L E ++ N+
Sbjct: 698 EVFQALEAGKKEEQEPRVIAGSIPAGSVHKFTWLFENCPMGSLAAESIQGGNL------- 750
Query: 1482 VQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETR 1541
+ ++ + PS + + E ET
Sbjct: 751 ------------------------------LEEQPMSPSGNR----------MQESQETA 770
Query: 1542 VEKIEIIGKSIKETLEDLYSQK-VIQAPGIIIEADEIGDVRMAKYKL--MNQASPEIQKE 1598
E TL L++ ++ GI++EA G++ +AKY L Q P I+KE
Sbjct: 771 AE----------GTLRTLHATPGILHHGGILMEARGPGELCLAKYVLSGTGQGHPYIRKE 820
Query: 1599 EIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGD 1658
E++ +L I+ +L + D ++ +L+ E+ G + L +L + + E D
Sbjct: 821 ELVSGELPRIICQVLRRPDVDQQGLLVQEDPTGQLQLKPLRLPTPGSSGNIE-------D 873
Query: 1659 VQQAIKNLFS---EERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKR 1715
+ ++ L + + G+++QE E+G + +T Y L
Sbjct: 874 MDPELQQLLACGLGTSVARTGLVMQETEQGLVALTAYSL--------------------- 912
Query: 1716 TIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTE 1764
R ASER +VQ +CI+ G L L L E
Sbjct: 913 --------------QPRLTSKASERSSVQLLASCIDKGDLSGLHSLRWE 947
Score = 94.0 bits (232), Expect = 2e-18
Identities = 120/517 (23%), Positives = 212/517 (41%), Gaps = 74/517 (14%)
Query: 1340 EEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQI 1399
EE GDV+ RW+FE LD+I + E + +E + GDV + +FE
Sbjct: 84 EEPTEGDVQCMRWIFENWRLDAIGEHE-----RPAAKEPVLCGDVQATSRKFEEGSFANS 138
Query: 1400 SEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQ--------KGNVKT 1451
+++ P+ GG+V+ +R FE++ D+ T E++ G+V+
Sbjct: 139 TDQE----PTRPQPGGGDVRAARWLFETKPLDE----LTGQAKELEATVREPAASGDVQG 190
Query: 1452 STWLFETHTMDELRGEGLEYENIKTVTQEDVQ--KGDVKQAVWLFENRTFDSIMEAHKGI 1509
+ LFET +D L E + ++Q KGDVK+ V LF+ +I +A I
Sbjct: 191 TRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGAI 250
Query: 1510 TKMT---KEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQ 1566
++ +EEI + V++ WLFET PL N+ D +VI+
Sbjct: 251 HEVKAACREEIQSNAVRSARWLFETRPLDAINQ------------------DPSQVRVIR 292
Query: 1567 APGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILIS 1626
GI +E DV ++ Q I++ + D + + D +++ L
Sbjct: 293 --GISLEEGARPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLFE 350
Query: 1627 EEEKGNVNLTKTQLLNRSTEFHAE---KEEIVKGDVQQAI-----KNLFSEERSVKKGIL 1678
L E AE KEE+V GDV+ + K L + V+ G L
Sbjct: 351 TRA--------LDTLKGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHL 402
Query: 1679 IQED-EKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDA 1737
+ D + G+ +++ + + + + GDVK T NL + + I + +
Sbjct: 403 QRVDPQDGEGHLSSDSSSALPFSQSAPQRDELKGDVK-TFKNLFETLPLDSIGQGEVLAH 461
Query: 1738 SERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLL------ 1791
+ + +A + +S L A ++I+GGDV+G + +
Sbjct: 462 GSPSREEGTDSAGQAQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMFETQPL 521
Query: 1792 --LKKRQSLVE--RTVSETDIIPGDVHNTVKVFMTEP 1824
L + S ++ R ++ +++ GDV +F T+P
Sbjct: 522 DQLGRSPSTIDVVRGITRQEVVAGDVGTARWLFETQP 558
Score = 48.5 bits (114), Expect = 1e-04
Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 36/218 (16%)
Query: 2949 RKREELQQILSRVKQFEAEPNKS-GLKTFQTLLNTIPGW-------LISEDKREYAVHIA 3000
R ++ELQ +L++V+ E E S ++ + L +P + K E +V A
Sbjct: 1466 RNQKELQGLLNQVQALEKEAASSVDVQALRRLFEAVPQLGGAAPQAPAAHQKPEASVEQA 1525
Query: 3001 MENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTS------LDETSS 3054
L +V E+ +K Q L+ E + A+ S + +P D ++
Sbjct: 1526 F-GELTRVSTEVAQLKEQTLARLLDIEEAVHKALSSMSSLQPEASARGHFQGPPKDHSAH 1584
Query: 3055 KVSNVHVSNNKNSEQKENKIAKEKTVQHQ--VAAHHEATVRSHVKTHQEIKLDDSNIPP- 3111
K+S V VS++ ++ + V++Q V H EA + ++ H E + ++ P
Sbjct: 1585 KIS-VTVSSSARPSGSGQEVGGQTAVKNQAKVECHTEAQSQVKIRNHTEARGHTASTAPS 1643
Query: 3112 -----------------PSLKTRPPSPTFITIESTARR 3132
PS + P SPTFI+I+S R+
Sbjct: 1644 TRRQETSREYLCPPRVLPSSRDSPSSPTFISIQSATRK 1681
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 69.7 bits (169), Expect = 5e-11
Identities = 159/824 (19%), Positives = 314/824 (38%), Gaps = 157/824 (19%)
Query: 2391 DFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSL 2450
D M++ S+++ + Q K + K + +L K ++ + +F ++++A
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELARK----------EQELTKKLQTREREFQEQMKVALEK 517
Query: 2451 SDME-CKITTSKDQK-----------KVMVMTSSEH--------TETK-------QNVIS 2483
S E KI+ K+Q+ K ++T SE+ ET ++ +
Sbjct: 518 SQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE 577
Query: 2484 KSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFP-ESSGQQNPKPYMRK--- 2539
KSL E K S D A L K+I +++ H ES Q + K
Sbjct: 578 KSLQENKNQSKDLAVHLE----AEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633
Query: 2540 ----FKTPLMIAEEKYRQQKEEIEKQKQ---------------ESSYYNIVKTQSQNQHI 2580
++T + EK Q+KE + K K+ E + +S + +
Sbjct: 634 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 693
Query: 2581 TEVEKEMPLQKTNEEVSL-----SGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPE 2635
+EV K K EE+S+ + E + ++ + ++++S E
Sbjct: 694 SEVLKAR--HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
Query: 2636 TVAAKRLHHVLAASEDKDKMKKE-----------VLQSSRDIMQSKSACEIKQSHQECST 2684
+++ + +++DK KE + +S ++ Q+ + ++ QS+Q +
Sbjct: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
Query: 2685 QQTQQKKYLEQLHLPQSK-------PISPNFKVKTIKLPTLD-------HTLNETDHSYE 2730
+QT K Y EQL Q K I +V ++ D H + D +
Sbjct: 812 EQT--KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ 869
Query: 2731 SHKQQSEIDVQTFTKKQYLKTKKTEASTECSH-KQSLAERHYQL------PKKEKRVTVQ 2783
KQ SE++ + + Q ++K + + E KQ L E+ + KKE + Q
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 2784 LPT-------------ESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGR 2830
+ E+ KNQE K++ V +K +E + + KL E K + +
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLK--KELEN 987
Query: 2831 KEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPY 2890
L + K + K + + DA +T +Q + T + E + +
Sbjct: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
Query: 2891 NSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKS---FFSSVKESQRDDGKGALNIVEF 2947
++ E++ I E Q+ ++ +QE+ + K F KE + E
Sbjct: 1048 EKKLNQQAEELQEIHEIQL----QEKEQEVAELKQKILLFGCEKEEMNKEITWLKE--EG 1101
Query: 2948 LRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHI-AMENNLE 3006
+++ L ++ ++KQ A N +++D+ + H+ +E +L
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNS-----------------LAQDETKLKAHLEKLEVDLN 1144
Query: 3007 KVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKN 3066
K +E T ++ Q ++ + E K + +K + DE + + H +NK+
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEE------DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Query: 3067 SEQKE---NKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDS 3107
E K K+++E +Q + + KT++ I + S
Sbjct: 1199 LEDKSLEFKKLSEELAIQLDICC-KKTEALLEAKTNELINISSS 1241
Score = 68.6 bits (166), Expect = 1e-10
Identities = 368/1892 (19%), Positives = 706/1892 (37%), Gaps = 282/1892 (14%)
Query: 1067 IKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMES-----LYEKVSLMTSS-EEIH 1120
I D + + EQ + +V + K + + ET M+ L ++ MT+ EE+
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETK--RQMHETLEMKEEEIAQLRSRIKQMTTQGEELR 402
Query: 1121 KGDVKTCTWLFET--QPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQ 1178
+ K+ FE + L T + E KL+ E+I +T E E + S+Q
Sbjct: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI-----KTIEKTSEEERI-SLQ 456
Query: 1179 GEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLN 1238
+E+ +K +D+ K + ++ +E+ KK++T + E ++ V
Sbjct: 457 -QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA- 514
Query: 1239 CRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKK 1298
E + +K SQE ++ E+ +L+E++ + I T+
Sbjct: 515 ----LEKSQSEYLKISQEKEQQ-------------------ESLALEELELQKKAILTES 551
Query: 1299 TITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKP 1358
+Q + ++YR T+ L E S E K+ +H + + E
Sbjct: 552 ENKLRDLQQEAETYR----TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 1359 LDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPL-DQISEESHNIMPSID-----H 1412
+ +K+E + +K V +Y+ E + L ++ +E ++ + H
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667
Query: 1413 IQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYE 1472
I+ N KT + V E++ + + S L H ++E E
Sbjct: 668 IEEMNEKTLEKL-------------DVKQTELESLSSELSEVLKARHKLEE------ELS 708
Query: 1473 NIKTVTQEDVQKGDVKQAVWL-FENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFET 1531
+K T + Q+ + K + DSI++ H+ + T++ + + L E
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 1532 TPLHEFNETRVEKIEI-IGKSIKETLEDLYSQKVIQA-PGIIIEADEIGDVRMAKYKLMN 1589
+ ++ VE +E I +S E + V Q+ E + + ++A+ +
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ---LQ 825
Query: 1590 QASPEIQKEEIIRADLRNIMVNLLSKRDCTEREI-------LISEEEKGNVNLTK----- 1637
Q +++ E I+ + V K CTE + L+ + EK N + +
Sbjct: 826 QKLLDLETERILLTK-QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 1638 TQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHE 1697
TQ+ E +++E K + + + KK I I + +I+ L E
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 1698 ------NDGDTIEREEVIGGDVKRTIHNLL--SSTSNNKISERAKIDASERGNVQFFTTC 1749
N +E+ + +++ T+ L K E ++ S++ QF
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK-QFNAKM 1003
Query: 1750 IE------AGALDYLKQLHT---ESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVE 1800
+E AG D + +L T E E+LT + ++I + ++ Q + E
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 1801 RTVSETDIIPGDVHNTVKVFMTEPQSTFGKIP--KEEIIKGDLTSTLNSLSQAVNQKTV- 1857
+ E + ++ + +F E + +I KEE +K D +TLN L + + QK+
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD--TTLNELQEQLKQKSAH 1121
Query: 1858 --------TKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTK 1909
TK + ++ + KSLKE++ ++ + + + ++ + E + K
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS--ELTSKLK 1179
Query: 1910 TEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIK-----KDAKAVMAGSSGE----- 1959
T + + LK E S +SL++ FK++ +E I+ K +A++ + E
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 1960 -QKTDI-------HQVAVQRNKNSLLQPKPGPFEPAAKWQ---GGADTLSQTMGKSCHGN 2008
KT+ Q + K +LL E A+ + +TL+ + ++ H
Sbjct: 1240 SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH-Q 1298
Query: 2009 LVEERTEVNLPKA---PKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVW 2065
L E+ ++ KA T K + +E N S + + K + E+ + +
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 2066 TDTTGEQHLRDEYMSRQLTS-TVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQ 2124
+ E+ + +S+QLT V ++N+++ E + A+ L+K +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ-------------YDE 1405
Query: 2125 QTYELRNDHQKMEGFHIKSPKKTKNIKI-LTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQ 2183
+ EL + Q + F + + K K + D S+K S + + + Q
Sbjct: 1406 EKCELLDQVQDL-SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQ 1464
Query: 2184 KQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVT-EMKVSEKSHNTFKATNKKR 2242
Q LK + Y K + IN LL E D N + E + K K+
Sbjct: 1465 IQLELKSKEAYE----KDEQIN------LLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 2243 ETDVHLKSQDF-LMKTNTSTGLKMAMERSLNPI--NFNPENNVKESEC--PLPPPSPPPP 2297
+ LKSQ +M+ K SLN + N+N + +++ E L
Sbjct: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 2298 PPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSER 2357
N E E + L + + L T+K + E + + KS+
Sbjct: 1575 EKDNRVKEAEEKI-----LTLENQVYSMKAELETKKKELEHVN----------LSVKSKE 1619
Query: 2358 ESSSMFLPPPPPPTPSQKPAHL--LSSSAPEKHSG---DFMQQYSQKEASNSQNSQAKII 2412
E L S+ A L L A +K + + Q +KE + +++ +
Sbjct: 1620 EE----LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675
Query: 2413 TGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSS 2472
T L + + HI + K L + S + + K V T
Sbjct: 1676 ELNT------KLQEREREVHILEEK--------LKSVESSQSETLIVPRSAKNVAAYTEQ 1721
Query: 2473 EHT----------ETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLI--- 2519
E E K +V+ ++L E+++L TV R + LI
Sbjct: 1722 EEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLE 1781
Query: 2520 ----KSHSFPESSGQQNPKPYMRKFKTPLMIAE--EKYRQQKEEIEKQKQESSYYNIVKT 2573
K H G + + K L++A+ EK + KQ E+ + ++ KT
Sbjct: 1782 HAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKT 1841
Query: 2574 --------QSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCS 2625
Q Q I E++ + QK V + + S+ +Q + +
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 2626 DNQLSTTSPETVAAKRLHHVLA-----------ASEDKDKMKKEVLQSSRDI----MQSK 2670
+N + V K L ++ A A +K K+ KE+++ +D+ + +
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 2671 SACEI--KQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTI-KLPTLDHTLNETDH 2727
EI K+ QE + Q+++ LE H K + F + K L+ T+ ET +
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Query: 2728 S--------YESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKR 2779
ESH++++ ++ +K T +++ L R ++ K +
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKKIAEKD-----DDLKRTAKRYEEILDAREEEMTAKVRD 2076
Query: 2780 VTVQLPTESIQKNQEDKLKMVPRKQREFSGSD 2811
+ QL E +QK + KL +Q E G+D
Sbjct: 2077 LQTQL--EELQKKYQQKL-----EQEENPGND 2101
Score = 55.5 bits (132), Expect = 9e-07
Identities = 146/742 (19%), Positives = 288/742 (38%), Gaps = 102/742 (13%)
Query: 2421 PPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVM---TSSEHTE- 2476
P P+ ++ ++ ++D P VE TS+ +E K Q+ ++ T H E
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 2477 -----TKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQ 2531
+++ + + LDER Q ++ L A + K I L + + E Q
Sbjct: 309 CTLLTSEKEALQEQLDERLQ-ELEKIKDLH------MAEKTKLITQLRDAKNLIEQLEQD 361
Query: 2532 NPKPYM---RKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMP 2588
R+ L + EE+ Q + I++ + K +S+ E+EK +
Sbjct: 362 KGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALS 421
Query: 2589 LQKTNEEVS---LSGIDSECTVVQPSPG------SQSNARILGVCSDNQLSTTSPETVAA 2639
+ EE + +D + ++ + Q +R+ D ++ +
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 2640 KRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKK--YLEQLH 2697
++LH A ++++ KK + Q K A E QS +Q+ +Q++ LE+L
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541
Query: 2698 LPQSKPI--------------SPNFKVKTIKL-PTLDHTLNETDH---------SYESHK 2733
L Q K I + ++ + ++L +L+ +L E + E +K
Sbjct: 542 L-QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 2734 QQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQ 2793
EI V K L++ K + + K + ++ YQ ++ R + E++ K
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK-- 658
Query: 2794 EDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVV 2853
DK + E + KL ++ + S+ E L K E + +
Sbjct: 659 -DKEIIFQAHIEEMNEKTLEKL--DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 2854 KQK-VIDAHLDSQTQNFQQTQIQTAESKAE------HKKLPQPYNSL-----QEEKCLEV 2901
K K ++A +D Q +N Q Q+ + + E K L N L + +K L+
Sbjct: 716 KMKQELEAKMDEQ-KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Query: 2902 KGIQEKQVFSNTKDSKQEITQNKS---FFSSVKESQRDDGKGALNIVEFLRKR---EELQ 2955
+ + ++ K S+ E+ Q + F S + + + K + L+++ E +
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
Query: 2956 QILSRVKQFEAEPNKSGLKT--------FQTLLNTIPGWLISEDKREYAVHIAMENNLEK 3007
+IL + E E K + T Q L+ + +++ ++ E+ LE
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 3008 VKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNN--- 3064
+E + Q + +LV EN+I + + G+ + S+K ++H+ N
Sbjct: 895 GNKE----QEQTKQILVEKENMI----LQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 3065 ---KNSEQKENKIAKEKTVQHQ 3083
KN E+K K+ K+K + Q
Sbjct: 947 TKFKNQEKKMEKV-KQKAKEMQ 967
Score = 48.1 bits (113), Expect = 2e-04
Identities = 99/496 (19%), Positives = 206/496 (41%), Gaps = 56/496 (11%)
Query: 2656 KKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKL 2715
K++++Q R + +S S+ K S + Q Q++K Q L QS+ S ++
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLR------RI 189
Query: 2716 PTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQ--- 2772
L L + D + H Q+ E D K QY+ +T+ S KQ L
Sbjct: 190 AELREEL-QMDQQAKKHLQE-EFDASLEEKDQYISVLQTQVSLL---KQRLRNGPMNVDV 244
Query: 2773 ---LPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIG 2829
LP+ E + V E+ + + E ++ + + R K + K ++
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS 304
Query: 2830 RKEERLITERKHEHLKNKSAPKVVK-QKVIDAHLDSQTQNFQQTQIQTAESKAEH----K 2884
KE+ + + E L+ + ++ + +K+ D H+ +T+ TQ++ A++ E K
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLI--TQLRDAKNLIEQLEQDK 362
Query: 2885 KLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNI 2944
+ Q + LE+K E+++ KQ TQ + ++S+R +
Sbjct: 363 GMVIAETKRQMHETLEMK---EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Query: 2945 VEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENN 3004
+ +K EE + ++ +AE ++ +KT + SE++R I+++
Sbjct: 420 LSTAQKTEEAR------RKLKAEMDEQ-IKTIEKT---------SEEER-----ISLQQE 458
Query: 3005 LEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNN 3064
L +VK+E+ + ++ + ++ + ++ K + K + + + V +
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL--- 515
Query: 3065 KNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFI 3124
+ S+ + KI++EK Q +A + + T E KL D + +TR +
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR-----IL 570
Query: 3125 TIESTARRTENPTKNE 3140
+ES+ ++ KN+
Sbjct: 571 ELESSLEKSLQENKNQ 586
Score = 46.2 bits (108), Expect = 6e-04
Identities = 111/615 (18%), Positives = 243/615 (39%), Gaps = 82/615 (13%)
Query: 2377 AHLLSSSAPEKHSGDFMQQYSQK------------EASNSQNSQAKIITGKTGVLPPPTL 2424
AH+ + A K S +QQ S K E + + Q + K L +
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 2425 PKPKLPKHIKDNKNDFSPKVEL-ATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVIS 2483
K ++ K D +++ + D+ ++ + + V + ++ E+K +
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 2484 KSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTP 2543
K ++ KQ+ ++ N + G +KK+I L + S E S + Y
Sbjct: 897 KEQEQTKQILVEKENMILQMREG----QKKEIEILTQKLSAKEDSIHILNEEY------- 945
Query: 2544 LMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDS 2603
E K++ Q++++EK KQ++ ++ + + + E ++ + N + LS +
Sbjct: 946 ----ETKFKNQEKKMEKVKQKAKEMQ----ETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 2604 ECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAA------KRLHHVLAASEDKDKMKK 2657
+ ++A I S +L T E + + + L+ V++ E K +
Sbjct: 998 QFNAKMLEMAQANSAGISDAVS--RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 2658 EVLQSSRDIMQSKSACEIKQSHQE-----CSTQQTQQK-KYLEQLHLPQSKPISP---NF 2708
E LQ +I + E+ + Q+ C ++ ++ +L++ + Q ++
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Query: 2709 KVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQ------TFTKKQYLKTK------KTEA 2756
K K+ + ++L + + ++H ++ E+D+ TF ++Q ++ K K +
Sbjct: 1116 KQKSAHV----NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 2757 STECSHKQSLAERHYQLPKKEKRVTVQLPTESIQ--KNQED---KLKMVPRKQREFSGSD 2811
S S ++ E L ++ L +S++ K E+ +L + +K +
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231
Query: 2812 RGKLPG--SEEKNQGPSMIGR--------KEERLITERKHEHLKNKSAPKVVKQKVIDAH 2861
+L S + N S I KE LI L+ + +Q ++
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291
Query: 2862 LDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEIT 2921
T ++ + Q KA+ + L +LQ+E + + EK+ S K+E++
Sbjct: 1292 FQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE--SCITQLKKELS 1349
Query: 2922 QNKSFFSSVKESQRD 2936
+N + + +KE ++
Sbjct: 1350 ENINAVTLMKEELKE 1364
Score = 44.7 bits (104), Expect = 0.002
Identities = 310/1863 (16%), Positives = 718/1863 (38%), Gaps = 265/1863 (14%)
Query: 508 ELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARY-VFENTNDSSQKDLNS-----ER 561
E R+ L+ + ++ I + S+ ++ + + V + SS++ + E+
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487
Query: 562 EYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMF 621
E ++ L ++Q+ F+ Q ++ + IS+ QE +A +++
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 622 ETQPIDTLGAYSSDTVENAEKIPELARG-DVCTARWMFETRPLDSMNKMHQSQEESAVTI 680
T+ + L + +I EL + +++ L + +++ +T+
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 681 SKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQP 740
+ +++++++ + ++L L + + +LR + ++ K + + +
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667
Query: 741 LYVIRDGSGQMLEIKTVHREDV--EKGDVRTARWMFETQPLDTINKDITEIKVVRGISME 798
+ + + + + L++K E + E +V AR E + ++ KD T+ M+
Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEEL--SVLKDQTD-------KMK 718
Query: 799 ENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPD 858
+ ++ + + K + Q IKE E I EK + +++ + + + + +
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 859 ADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFET 918
++L+ D++ ++ E + S + Q ++ E+ ++
Sbjct: 779 VENLE------ADIKRSEG-------ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825
Query: 919 QPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVEL 978
Q L D+ ++ T+ V E + DV + DA HKI+V+ + + +
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDV-----------CTELDA-HKIQVQDLMQQLEKQ 873
Query: 979 NKSLFET----TPLYAIQDPLGKYHQVKT----VQQEEIV----RGDVRSCRWLFETRPI 1026
N + + T +Y + G Q +T V++E ++ G + L T+ +
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL--TQKL 931
Query: 1027 DQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDI 1086
++SIH I +E +T F+ Q +E+ + K ++ ++
Sbjct: 932 SAKEDSIH-------ILNEEYETK--------FKNQE-------KKMEKVKQKAKEMQET 969
Query: 1087 VKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDS--- 1143
+K K L + ++ E +L S +E F + L+ + +S
Sbjct: 970 LKK-----KLLDQEAKLKKELENTALELSQKEKQ----------FNAKMLEMAQANSAGI 1014
Query: 1144 -ETAVKLQTVKQEEIQGGDVRTACFLFETENLDSI-------QGEEVKEIKPVEMDIQAG 1195
+ +L+T ++E+I+ T E ++ SI Q EE++EI +++ +
Sbjct: 1015 SDAVSRLETNQKEQIES---LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1196 DVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQ 1255
+V+ ++ Q + EE+ K+I LK E +++ LN Q +
Sbjct: 1072 EVAELK-----QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 1256 EGDECVKTVTDIQGGDVRKGC----FIFETFS-----LDEIKEESDYISTKKTITEEVIQ 1306
+ + +K + D+ K F+ E +E K + +++K T+E Q
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQ 1186
Query: 1307 GDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDV--RGTRWLFETKPLDSIN- 1363
S+ ++ ++D+ + +++ +E I D+ + T L E K + IN
Sbjct: 1187 SLKSSHEKSNKS-----LEDKSLEFKKLS---EELAIQLDICCKKTEALLEAKTNELINI 1238
Query: 1364 --------------------KSETVYVIKSVTQEDIQ--------KGDVSSVRYRFETQP 1395
K + +IK+ T +++ + + ++ ++ T
Sbjct: 1239 SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
Query: 1396 LDQISEESHNIMPSIDHI---------QGGNVKTSRQFFES------ENFDKNNYIRTVS 1440
L++ + ++ I+ + +GGN + + ES + +N T+
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 1441 VNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFD 1500
E+++ V+ S+ +L ++ +N ++++++ +++ + D
Sbjct: 1359 KEELKEKKVEISS------LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 1501 SIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLY 1560
+ + + ++KE+I + + W + + + ++R + + K ++ LE
Sbjct: 1413 QVQDLSFKVDTLSKEKISALE-QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 1561 SQKVIQAPGIIIEADEIGDVRMA----KYKLMNQASPEIQKEEIIRADLRNIMVNLLSKR 1616
+ + I + +E+ K ++ + S +KE + +L++ ++
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 1617 D-CTEREILISE--EEKGNVNLTK-------TQLLNRSTEFHAEKEEIVKGDVQQAIKNL 1666
D T++ I I E N N K Q L E EK+ VK + ++ I L
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK-EAEEKILTL 1590
Query: 1667 FSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSN 1726
++ S+K + ++ E +N+++ +EE + + + + L S S
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVK-----------SKEEEL-----KALEDRLESESA 1634
Query: 1727 NKISE-RAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDV 1785
K++E + K + + + +E Y K + +E L K QE E+E+
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE-LNTKLQEREREVH---- 1689
Query: 1786 EGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTL 1845
+L+++ VE + SET I+P N E + G + K K +
Sbjct: 1690 -----ILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 1846 NSLSQAVNQKTVTKTEEIIKGNM---LATLKSLKESSHRWKESKQPDAIPGDIEKAIECL 1902
+ + + Q+ + EE + + + L + H + + ++ G ++ E L
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ---EEL 1801
Query: 1903 EKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKK------DAKAVMAGS 1956
E+ + I+ + + K+ + ++++ + + F +V K K+ + K S
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 1957 SGEQKTDIHQVAVQR-----NKNSLLQPKPGPFEPAAKWQGGADTLSQT--MGKSCHGNL 2009
++ ++H+V ++ K LQ G +P + + S++ + N+
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNM 1921
Query: 2010 VEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTT 2069
+ ++ A K + +E L+K LR L H + LE K D
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVR--LQKDLRMLRKEHQQE--LEILKKE---YDQE 1974
Query: 2070 GEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTY-- 2127
E+ ++ E +L ++K + + A +E + + + +T+ K Q
Sbjct: 1975 REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE------MTIKETINKAQEVEA 2028
Query: 2128 ELRNDHQKMEGFHIKS-PKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQK-- 2184
EL HQ+ +K +K ++K + ++ V + QK
Sbjct: 2029 ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY 2088
Query: 2185 QTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRET 2244
Q L+QE N ++ + Q + + S + E + E+ HN + KK E
Sbjct: 2089 QQKLEQEENPGNDNVTIMELQTQLAQKTTLISD--SKLKEQEFREQIHN-LEDRLKKYEK 2145
Query: 2245 DVH 2247
+V+
Sbjct: 2146 NVY 2148
Score = 40.8 bits (94), Expect = 0.024
Identities = 47/207 (22%), Positives = 92/207 (44%), Gaps = 14/207 (6%)
Query: 2530 QQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQE--SSYYNIVKTQSQNQHITEV-EKE 2586
Q++ + ++ + L I +++Y Q++EE KQ+QE +N Q + T++ +KE
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009
Query: 2587 MPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVC-SDNQLSTTSPETVAAKRLHHV 2645
L+ T +E + E +++ S ++N + + D+ L T AKR +
Sbjct: 2010 QELEMTIKETINKAQEVEAELLE-SHQEETNQLLKKIAEKDDDLKRT------AKRYEEI 2062
Query: 2646 LAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPIS 2705
L A E++ K LQ+ + +Q K +++Q + T + Q L Q +
Sbjct: 2063 LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL---QTQLAQKTTLI 2119
Query: 2706 PNFKVKTIKLPTLDHTLNETDHSYESH 2732
+ K+K + H L + YE +
Sbjct: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKN 2146
Score = 33.5 bits (75), Expect = 3.8
Identities = 38/169 (22%), Positives = 81/169 (47%), Gaps = 24/169 (14%)
Query: 307 EQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTP--EDEEIPKVS--- 361
+Q+ + V + T++ +HLEK ++N++ + + ++QE +++ +E+ KVS
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 362 --TKLLKEQFE--KSAQEKILYSDKEMTTPAKQI-------------KTESEYEETFKPS 404
K E+F+ KS+ EK S ++ + K++ KTE+ E
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 405 SVVSTSSTSCV-STSQRKETSTTRYSDH-SVTSSTLAQINATSSGMTEE 451
+S+S T+ + S + TT+ + + + T++++ A +TEE
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 63.9 bits (154), Expect = 3e-09
Identities = 141/709 (19%), Positives = 286/709 (40%), Gaps = 87/709 (12%)
Query: 2428 KLPKHIKDNK--NDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEH----TETKQNV 2481
+L + ++ NK D + L +S ++ K+ ++ + + + EH ET Q
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 2482 ISKSLDERKQLSIDSANC---LSHTVPGTS---APRKKQIAPLIKSH---------SFPE 2526
I ++LS ++ + L H S A K ++ I SH SF +
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
Query: 2527 SSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEV--E 2584
G + + + KT + Y+ + E ++ Q+ + + ++ + +V E
Sbjct: 602 GLGTETAE--FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659
Query: 2585 KEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHH 2644
KE L+ ++ + D ++ + A I + + + +T
Sbjct: 660 KENSLEAIRSKLDKAE-DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 2645 VLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKP- 2703
L A+E+K + + L+ + S+ E+K+ Q+ + Q K + + SK
Sbjct: 719 QLKATEEK-LLDLDALRKA----SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Query: 2704 -ISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTEC-S 2761
I+ + + +KL L L+E E+ +++ +I LK K EAS E S
Sbjct: 774 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQI----------LKEKFAEASEEAVS 823
Query: 2762 HKQSLAERHYQLPKKEKRVTV-QLPTESIQKN---------QEDKLKMVPRKQREFSGSD 2811
++S+ E +L +KE++ + E +++N ++D+ + K +E +D
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 2812 RGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQ 2871
++ N + +E + ER E L+ K + ++ T +Q
Sbjct: 884 IAEIMKMSGDNSS-QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942
Query: 2872 TQIQTAESKAEHKK-LPQPYNSLQEE------KCLEVKGIQEKQVFSNTKDSKQEITQN- 2923
+Q + A+ E KK L + + L+++ +C E+K E+ S TK +EI QN
Sbjct: 943 SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT-SETKTKHEEILQNL 1001
Query: 2924 -KSFFSSVK--ESQRDDGKGALNIVEFLRK---REELQQILSRVKQFEAEPNKSGLKTFQ 2977
K+ + + R++ G L +E LRK + + Q Q + K +T
Sbjct: 1002 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1061
Query: 2978 TLLNTIPGWLISEDKREYAVHIAMENNLEKV------KEEITHIKTQAEDMLVSYENIIQ 3031
+L +T + K + + ENNL+ V KE +T + E+ E + Q
Sbjct: 1062 SLEDTKQ----TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
Query: 3032 TAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTV 3080
A S+ + ++L E + K++ + +++ K+ +E++V
Sbjct: 1118 AAAQKSQ------QLSALQEENVKLAE-ELGRSRDEVTSHQKLEEERSV 1159
Score = 43.5 bits (101), Expect = 0.004
Identities = 139/728 (19%), Positives = 278/728 (38%), Gaps = 83/728 (11%)
Query: 5 QKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPTSLPY 64
++ SL +R K + + Q H + T+ + QE+++ E EV+ A + +
Sbjct: 660 KENSLEAIRSKLDKAEDQ----HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 715
Query: 65 STGEEMWSSKPEEKDSVDKSNNTREYGRPEV--LKEDSLSSRRRIERFSIALDELRSVFE 122
T + + E+ +D G+ E+ L++ ++ ++I+ E+ E
Sbjct: 716 FTSQ--LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL-----EIEKNAE 768
Query: 123 APKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPESGH 182
+ K+ + E G+E+++ + + S LE ++ +K E S + +S +
Sbjct: 769 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 828
Query: 183 SRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANM 242
E ++ E F S SDL + L+E +A +A D R
Sbjct: 829 Q---ETVNKLHQKEEQFNMLS-------SDLEK---LRENLADMEAKFREKDEREEQLIK 875
Query: 243 MEE------SEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSE-----QEAIHS 291
+E +E+ + G + + DE+ + Q + +E Q++I
Sbjct: 876 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 292 SQVGTSRSSQEMARNEQEGSKV---------QKIDVHGT---EMVSHLEKHTEEVN-QAS 338
V +S QE A+ +E K +K++ E+ + E+ T E +
Sbjct: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
Query: 339 QFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYE 398
+ Q +Q+T++DT + + + L ++ E+ ++ + A QI + E
Sbjct: 996 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055
Query: 399 ETFKPSSVVSTSSTSCVSTSQ---RKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPP 455
+T +S+ T T+ ++ KE + + + + L N +E
Sbjct: 1056 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1115
Query: 456 PPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEK 515
Q S ++A + E L +D + + L E + + E++K E
Sbjct: 1116 KQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ES 1172
Query: 516 DYISEVSEIVSSQMNSGSSVSA-----DVQQARYVFENT----NDSSQKDLNSEREYLEW 566
+I + E +S S S SA D + + E T ++S K L+S + LE
Sbjct: 1173 KFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLES 1232
Query: 567 DEI-LKGEVQSIR-WIFENQPLDSINNGSPD-EGDISRGIADQEI-----------IAGG 612
D++ L+ +V+++ + EN+ S ++G+ D + D + +I
Sbjct: 1233 DKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQ 1292
Query: 613 DVKYTTWMFETQPI----DTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNK 668
D+K M + D L Y SD E K D+C + +T + +
Sbjct: 1293 DLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQ 1352
Query: 669 MHQSQEES 676
M + S
Sbjct: 1353 MSEDPPHS 1360
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 63.9 bits (154), Expect = 3e-09
Identities = 141/709 (19%), Positives = 286/709 (40%), Gaps = 87/709 (12%)
Query: 2428 KLPKHIKDNK--NDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEH----TETKQNV 2481
+L + ++ NK D + L +S ++ K+ ++ + + + EH ET Q
Sbjct: 517 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 576
Query: 2482 ISKSLDERKQLSIDSANC---LSHTVPGTS---APRKKQIAPLIKSH---------SFPE 2526
I ++LS ++ + L H S A K ++ I SH SF +
Sbjct: 577 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 636
Query: 2527 SSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEV--E 2584
G + + + KT + Y+ + E ++ Q+ + + ++ + +V E
Sbjct: 637 GLGTETAE--FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 694
Query: 2585 KEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHH 2644
KE L+ ++ + D ++ + A I + + + +T
Sbjct: 695 KENSLEAIRSKLDKAE-DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 2645 VLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKP- 2703
L A+E+K + + L+ + S+ E+K+ Q+ + Q K + + SK
Sbjct: 754 QLKATEEK-LLDLDALRKA----SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808
Query: 2704 -ISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTEC-S 2761
I+ + + +KL L L+E E+ +++ +I LK K EAS E S
Sbjct: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQI----------LKEKFAEASEEAVS 858
Query: 2762 HKQSLAERHYQLPKKEKRVTV-QLPTESIQKN---------QEDKLKMVPRKQREFSGSD 2811
++S+ E +L +KE++ + E +++N ++D+ + K +E +D
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 918
Query: 2812 RGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQ 2871
++ N + +E + ER E L+ K + ++ T +Q
Sbjct: 919 IAEIMKMSGDNSS-QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977
Query: 2872 TQIQTAESKAEHKK-LPQPYNSLQEE------KCLEVKGIQEKQVFSNTKDSKQEITQN- 2923
+Q + A+ E KK L + + L+++ +C E+K E+ S TK +EI QN
Sbjct: 978 SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT-SETKTKHEEILQNL 1036
Query: 2924 -KSFFSSVK--ESQRDDGKGALNIVEFLRK---REELQQILSRVKQFEAEPNKSGLKTFQ 2977
K+ + + R++ G L +E LRK + + Q Q + K +T
Sbjct: 1037 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096
Query: 2978 TLLNTIPGWLISEDKREYAVHIAMENNLEKV------KEEITHIKTQAEDMLVSYENIIQ 3031
+L +T + K + + ENNL+ V KE +T + E+ E + Q
Sbjct: 1097 SLEDTKQ----TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1152
Query: 3032 TAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTV 3080
A S+ + ++L E + K++ + +++ K+ +E++V
Sbjct: 1153 AAAQKSQ------QLSALQEENVKLAE-ELGRSRDEVTSHQKLEEERSV 1194
Score = 43.5 bits (101), Expect = 0.004
Identities = 139/728 (19%), Positives = 278/728 (38%), Gaps = 83/728 (11%)
Query: 5 QKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPTSLPY 64
++ SL +R K + + Q H + T+ + QE+++ E EV+ A + +
Sbjct: 695 KENSLEAIRSKLDKAEDQ----HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 750
Query: 65 STGEEMWSSKPEEKDSVDKSNNTREYGRPEV--LKEDSLSSRRRIERFSIALDELRSVFE 122
T + + E+ +D G+ E+ L++ ++ ++I+ E+ E
Sbjct: 751 FTSQ--LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL-----EIEKNAE 803
Query: 123 APKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPESGH 182
+ K+ + E G+E+++ + + S LE ++ +K E S + +S +
Sbjct: 804 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 183 SRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANM 242
E ++ E F S SDL + L+E +A +A D R
Sbjct: 864 Q---ETVNKLHQKEEQFNMLS-------SDLEK---LRENLADMEAKFREKDEREEQLIK 910
Query: 243 MEE------SEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSE-----QEAIHS 291
+E +E+ + G + + DE+ + Q + +E Q++I
Sbjct: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
Query: 292 SQVGTSRSSQEMARNEQEGSKV---------QKIDVHGT---EMVSHLEKHTEEVN-QAS 338
V +S QE A+ +E K +K++ E+ + E+ T E +
Sbjct: 971 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 1030
Query: 339 QFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYE 398
+ Q +Q+T++DT + + + L ++ E+ ++ + A QI + E
Sbjct: 1031 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090
Query: 399 ETFKPSSVVSTSSTSCVSTSQ---RKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPP 455
+T +S+ T T+ ++ KE + + + + L N +E
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 456 PPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEK 515
Q S ++A + E L +D + + L E + + E++K E
Sbjct: 1151 KQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ES 1207
Query: 516 DYISEVSEIVSSQMNSGSSVSA-----DVQQARYVFENT----NDSSQKDLNSEREYLEW 566
+I + E +S S S SA D + + E T ++S K L+S + LE
Sbjct: 1208 KFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLES 1267
Query: 567 DEI-LKGEVQSIR-WIFENQPLDSINNGSPD-EGDISRGIADQEI-----------IAGG 612
D++ L+ +V+++ + EN+ S ++G+ D + D + +I
Sbjct: 1268 DKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQ 1327
Query: 613 DVKYTTWMFETQPI----DTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNK 668
D+K M + D L Y SD E K D+C + +T + +
Sbjct: 1328 DLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQ 1387
Query: 669 MHQSQEES 676
M + S
Sbjct: 1388 MSEDPPHS 1395
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 63.9 bits (154), Expect = 3e-09
Identities = 164/821 (19%), Positives = 307/821 (37%), Gaps = 152/821 (18%)
Query: 2300 SNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSE--R 2357
S + E P PPP MM+ LP S L PPPP+ S
Sbjct: 1228 SELDDQEEPPFVPPPGYMMYT----VLPDGSP------VPQGMALYAPPPPLPNNSRPLT 1277
Query: 2358 ESSSMFLPPPP-------PPTPSQK----PAHLLSSSAPEKHS--------GDFMQQYSQ 2398
+ ++ PPP PP P+ P +L + PE H+ D MQ
Sbjct: 1278 PGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHNLENEVSRLEDIMQHLKS 1337
Query: 2399 KEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKI- 2457
K+ +K + K +L +I D L +EC++
Sbjct: 1338 KKREERWMRASKRQSEK---------EMEELHHNIDD----------LLQEKKSLECEVE 1378
Query: 2458 ----TTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKK 2513
T K Q++ + + + + I KSL + + +D C+ T+ + ++
Sbjct: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDI-VDEIECIEKTLLKRRSELRE 1437
Query: 2514 QIAPLIKSHSFPESSGQQNPKPYMRKF---KTPLMIAEEKYRQQKEEIEKQKQESSYYNI 2570
L ++ S S ++ K + KF K L+ E EE+E++ QE++ N+
Sbjct: 1438 ADRLLAEAES-ELSCTKEKTKNAVEKFTDAKRSLLQTE----SDAEELERRAQETA-VNL 1491
Query: 2571 VKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLS 2630
VK Q + + K++ K +E L I N + SD Q
Sbjct: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEI---------------NKIVAAKDSDFQCL 1536
Query: 2631 TTSPE--TVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSA------CEIKQSHQEC 2682
+ E T ++L + +E + +VL+ S ++Q+K A ++ QE
Sbjct: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEM 1596
Query: 2683 STQQTQQKKYLEQLHLPQSKPISPNFKV-------KTIKLPTLDHTLNETDHSYESHKQQ 2735
+ Q E+LHL Q + + +T +H E Q+
Sbjct: 1597 AVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQK 1656
Query: 2736 SEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTES------- 2788
E++VQ +K L K E E + Q + + + + K + L E+
Sbjct: 1657 GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLK 1716
Query: 2789 ---------IQKNQ----EDKLKMVPRKQREFSGSDRGKLPGSE-----EKNQGPSM--- 2827
++K Q E+KL++ ++ S +G++ + +K + M
Sbjct: 1717 LQHDQRVSELEKTQVAVLEEKLEL--ENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
Query: 2828 ----------IGRKEERL-----ITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQT 2872
+ +++E L I E+K K A K+ ++L+ N ++
Sbjct: 1775 SRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 2873 QIQTAESKAEHKKLPQPYNSLQ---EEKCLEVKGIQEKQVFSNTKD----SKQEI---TQ 2922
Q + + + L +++Q +EK V +QE+ +N +D +KQ++ T+
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEE--LANVQDHLNLAKQDLLHTTK 1892
Query: 2923 NKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNT 2982
++ S + + D N E +K EE +Q +V Q E E NK L + +
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR 1952
Query: 2983 IPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDML 3023
+ SE+ + + ++ ++++E+T K++ + +L
Sbjct: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVL 1993
Score = 39.7 bits (91), Expect = 0.054
Identities = 191/1030 (18%), Positives = 393/1030 (38%), Gaps = 185/1030 (17%)
Query: 1072 DVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLF 1131
++ T K +Q +D + G+V++ + E + +SL ++ E I K +K + L
Sbjct: 1379 ELHRTVQKRQQQKDFIDGNVESL--MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
Query: 1132 ETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEV-KEIKPVEM 1190
E L + +SE + + K + D + + L +TE+ EE+ + + +
Sbjct: 1437 EADRL-LAEAESELSCTKEKTKNAVEKFTDAKRS--LLQTES----DAEELERRAQETAV 1489
Query: 1191 DIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDK 1250
++ D + + + L+ EE+LK+I + K + C + K
Sbjct: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA---KDSDFQC--------LSK 1538
Query: 1251 IKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVK 1310
KE +E K DI+ + + + ++ +ES+ + K E ++ V
Sbjct: 1539 KKEKLT-EELQKLQKDIEMAERNEDHHL-------QVLKESEVLLQAKRAELEKLKSQVT 1590
Query: 1311 SYRMLFETQPLYAIQDREGSYHEVTTVKKEEV---------IHGDVRGTRWLFETKPLDS 1361
S Q A+ DR+ + KKEE+ D++ L ET+ +
Sbjct: 1591 SQ------QQEMAVLDRQLGH------KKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
Query: 1362 INKSETVYVIKSVTQE-DIQKGDVS---SVRYRFETQPLDQISEESHNIMPSIDHIQGGN 1417
N + +KS+ +E QKG+++ S R T +I +E N+ + +
Sbjct: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
Query: 1418 --VKTSRQFFESENFDKNNYI--RTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYEN 1473
+K + EN + V+E++K V E LE EN
Sbjct: 1696 TELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE-------------EKLELEN 1742
Query: 1474 IKTVTQEDVQKGDVKQAVWLFE------------NRTFDSIMEAHKGITKMTKEEIPPSD 1521
++ ++Q+ QKG+++ L E +R S +E + +E+ +
Sbjct: 1743 LQQISQQ--QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
Query: 1522 VK---TTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIG 1578
K T L + ++ +EK+E+ + +++ L+ L K+ I ++
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
Query: 1579 DVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKT 1638
+ R A L + + + + DL + + +++L+SE+ + +++
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKH---------QDVLLSEQTRLQKDIS-- 1909
Query: 1639 QLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERS--VKKGILIQEDEKGDINMTIYCLLH 1696
+ NR + +KEE K Q ++N E + V++ ++ Q +K
Sbjct: 1910 EWANRFED--CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE----------R 1957
Query: 1697 ENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALD 1756
E++ +E +V +K H L ++ K +K+D
Sbjct: 1958 ESEESKLETSKVT---LKEQQHQLEKELTDQK----SKLD-------------------Q 1991
Query: 1757 YLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKR-QSLVERT------VSETDII 1809
L ++ T +++E E + + TK L +R Q LVE++ E D +
Sbjct: 1992 VLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
Query: 1810 PGDVHNTVKVFMTEPQSTFGKIPK-EEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNM 1868
D F+TE + ++ +E +K + +L + + + + E
Sbjct: 2052 RADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKE------- 2104
Query: 1869 LATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRS 1928
+AT++ + + +H + ++ L + TE+ K+ + DLE
Sbjct: 2105 MATIELVAQDNHE------------RARRLMKELNQMQYEYTELKKQMANQKDLERRQME 2152
Query: 1929 LKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKN------SLLQPKP- 1981
+ +A R+ K K+ + + + + E D+ + ++RN+N SL + P
Sbjct: 2153 ISDAMRTLKSEVKDEI--RTSLKNLNQFLPELPADLEAI-LERNENLEGELESLKENLPF 2209
Query: 1982 ----GPFEPAAKWQGGADTLSQTMGKSCHGNL--VEERTEVNLPKAPKGTVKIVIDREQN 2035
GPFE + G++ L E+R + L +++I ++
Sbjct: 2210 TMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQ 2269
Query: 2036 NDALEKSLRR 2045
+ SLRR
Sbjct: 2270 TEGTLHSLRR 2279
Score = 32.7 bits (73), Expect = 6.6
Identities = 73/391 (18%), Positives = 164/391 (41%), Gaps = 52/391 (13%)
Query: 2544 LMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGI-- 2601
L + +++ Q+ + E++ +ES T + QH ++EKE+ QK+ + LS +
Sbjct: 1941 LKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH--QLEKELTDQKSKLDQVLSKVLA 1998
Query: 2602 --DSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMK--- 2656
+ T+ + +S + L S + + E ++ +LA ++ D M+
Sbjct: 1999 AEERVRTLQEEERWCESLEKTL---SQTKRQLSEREQQLVEKSGELLALQKEADSMRADF 2055
Query: 2657 --------KEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNF 2708
E ++ + + K A +I++S E + + +Q+ Q + + ++ +
Sbjct: 2056 SLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDN 2115
Query: 2709 KVKTIKLPTLDHTLNETDHSYESHKQ----QSEIDVQTFTKKQYLKTKKTEASTECSHKQ 2764
+ +L LN+ + Y K+ Q +++ + ++T K+E E +
Sbjct: 2116 HERARRLM---KELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI--RT 2170
Query: 2765 SLAERHYQLPK--------KEKRVTVQLPTESIQKNQEDKLKMVPRKQR-EFSGSDRGKL 2815
SL + LP+ E+ ++ ES+++N + P +++ FS ++
Sbjct: 2171 SLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFS-----QV 2225
Query: 2816 PGSEEKNQGPSM---IGRKEERLITERKHEHLKNKSAPKVVK-QKVIDAHLDS---QTQN 2868
+E +G ++ + +E+RL + + H +K A ++K ++ + L S Q
Sbjct: 2226 HIMDEHWRGEALREKLRHREDRLKAQLR--HCMSKQAEVLIKGKRQTEGTLHSLRRQVDA 2283
Query: 2869 FQQTQIQTAESKAEHKKLPQPYNSLQEEKCL 2899
+ T+ A L Q +SL E+ L
Sbjct: 2284 LGELVTSTSADSASSPSLSQLESSLTEDSQL 2314
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 63.5 bits (153), Expect = 3e-09
Identities = 139/729 (19%), Positives = 287/729 (39%), Gaps = 61/729 (8%)
Query: 2393 MQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSD 2452
MQ +KE ++ N K+ + G +P L +L I D + + + +VE +L +
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
Query: 2453 MECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRK 2512
++ K + E + K + E+ +L + + S V G
Sbjct: 742 EVILLSELKSLPSEVERLRKE-IQDKSEELHIITSEKDKLFSEVVHKESR-VQGLLEEIG 799
Query: 2513 KQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVK 2572
K L + S +S+ Q+ + FKT M E+KY+ EE E+ QE IV
Sbjct: 800 KTKDDLATTQSNYKSTDQE-----FQNFKTLHMDFEQKYKMVLEENERMNQE-----IVN 849
Query: 2573 TQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTT 2632
+ Q + + + KT + + VQ + D+ L T
Sbjct: 850 LSKEAQ---KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV 906
Query: 2633 SPE-TVAAKRLHHVL----AASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQT 2687
E T+ ++L L +++KD +K+ LQ S I + + +I + Q
Sbjct: 907 EREKTLITEKLQQTLEEVKTLTQEKDDLKQ--LQESLQIERDQLKSDIHDTVNMNIDTQE 964
Query: 2688 QQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQ 2747
Q + LE L Q + K K + + + + E + QQ + + KKQ
Sbjct: 965 QLRNALES--LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGID---KKQ 1019
Query: 2748 YLKTKKTEASTECSHKQSLAERHYQLPK--KEKRVTVQLPTESIQKNQEDKLKMVPRKQR 2805
L+ K T+ T + E+ ++ +EK Q+ I + ++ K + +
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 2806 EFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQ 2865
+ +L G E K Q + K + E + ++ A K K L +
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 2866 TQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKC----LEVKGIQEKQVFSNTKDSKQEIT 2921
Q Q + +E + + ++ N L+ ++ +E + ++ Q + + + IT
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 2922 QNKSFFSSVK---ESQRDDGKGALNIVEF--LRKREELQQILSRVKQFEAEPNKSGLKTF 2976
+ + ++ E++RD +G + +E L+ +EEL+ +K+ + +T
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ--------ETI 1251
Query: 2977 QTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMS 3036
L + +SE + +E + K++EEI + + +++L + + + +T
Sbjct: 1252 DELRRS-----VSEKTAQIINTQDLEKSHTKLQEEIP-VLHEEQELLPNVKEVSETQETM 1305
Query: 3037 SKTGKPGNKPTSLDETS---SKVSNVHVSNNKNSEQKENK-IAKE----KTVQHQVAAHH 3088
++ + T+ D T+ ++ + ++ Q+E K + KE KT++ + H
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 3089 EATVRSHVK 3097
+ ++ H++
Sbjct: 1366 D-QLKEHIR 1373
Score = 60.5 bits (145), Expect = 3e-08
Identities = 140/712 (19%), Positives = 299/712 (41%), Gaps = 87/712 (12%)
Query: 2431 KHIKDNKNDFSPKVE-LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDER 2489
K +K+ + F + + L + ++E +K++ K+ + EH ET + +S+ E+
Sbjct: 1203 KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEK 1261
Query: 2490 KQLSIDSANC-LSHTVPGTSAP---RKKQIAPLIKSHSFPESSGQQ----------NPKP 2535
I++ + SHT P ++++ P +K S + + +
Sbjct: 1262 TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321
Query: 2536 YMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQ------NQHITEVEKEMPL 2589
+ + + + EK+++ +EEI+ +E +K + +HI E ++
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381
Query: 2590 QKTNEEVSLS--GIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVA-AKRLHHVL 2646
++ +E SL+ D+E T + S Q + D+ L E + +KRL
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIV-SEMEQFKPK------DSALLRIEIEMLGLSKRLQ--- 1431
Query: 2647 AASEDKDKMK-----KEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHL--- 2698
E D+MK K+ LQ ++++QS+S ++K++ +E + + ++ L+ H
Sbjct: 1432 ---ESHDEMKSVAKEKDDLQRLQEVLQSESD-QLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 2699 PQSKPISP---NFKVKTIKLPTLDHTL--------NETDHSYESH-----KQQSEIDVQT 2742
Q + I+ N K ++ T+ L N+ YE KQ SE+ +
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 2743 FTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPR 2802
KQ+ + +K + S S + + E +L + ++ + + + + K ++ L++
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 2803 KQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHL 2862
+ +E + K+ S+EK + E + EHLK + + + + I
Sbjct: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI---- 1663
Query: 2863 DSQTQNFQQTQI--QTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKD-SKQE 2919
+T+N + TQI + E K S++E +E ++E + T+D KQE
Sbjct: 1664 --ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721
Query: 2920 ITQNKSFFSSVKESQR--DDGKGALN--IVEFLRKREELQQILSRVK------QFEAEPN 2969
+ K +KE Q D +G ++ E +++L+ +K Q E
Sbjct: 1722 --ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 2970 KSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENI 3029
LK Q ++ + G + + + + +EN+ K++E+I +K ++ +++
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 3030 IQTAMMSSKTG--KPGNKPTSLDETSSKVSNVHVSNNKNSEQKENK-IAKEK 3078
+T S+ K K SL + ++ N++++ + +E K + KE+
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER 1891
Score = 55.1 bits (131), Expect = 1e-06
Identities = 309/1766 (17%), Positives = 686/1766 (38%), Gaps = 272/1766 (15%)
Query: 261 QFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHG 320
Q EI++ +N + +Q+ + SS+V R ++ + QE QK++
Sbjct: 551 QLIHEISNLKNLVKHAEVYNQDLENEL---SSKVELLREKEDQIKKLQEYIDSQKLENIK 607
Query: 321 TEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYS 380
++ LE E+ Q Q + +D + + LKE+
Sbjct: 608 MDLSYSLES-IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKM----------- 655
Query: 381 DKEMTTPAKQIKTESE-YEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLA 439
KE+ T KQ++ + + Y+ + + + ++ + T T D V L
Sbjct: 656 -KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 440 --QINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLY- 496
++ + + +E + +V S+ LPS RL K++ K L+
Sbjct: 715 NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR--KEIQDKSEELHI 772
Query: 497 ---ELNRLYKHI-HPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDS 552
E ++L+ + H E R + I + + +++ ++ S + Q + + D
Sbjct: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM---DF 829
Query: 553 SQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGG 612
QK + LE +E + E+ ++ E Q DS S G E+
Sbjct: 830 EQK----YKMVLEENERMNQEIVNLSK--EAQKFDS-----------SLGALKTEL---- 868
Query: 613 DVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQS 672
++TQ + + + E++ E T + + + L +
Sbjct: 869 -------SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921
Query: 673 QEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRS 732
+E +T KD D+K ++ + + +H +++ + +L+ ++K+
Sbjct: 922 EEVKTLTQEKD----DLKQLQESLQIERDQLKSDIHDTVNMNI-DTQEQLRNALESLKQH 976
Query: 733 IKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVV 792
+ T + + S + +H E+ G+ + F+ + + K E K
Sbjct: 977 QETINTLKSKISEEVS------RNLHMEE-NTGETKDE---FQQKMVGIDKKQDLEAKNT 1026
Query: 793 RGISMEENVKGGVSKAKWLF----ETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQ 848
+ ++ + + + + +F E L+++ ES VI EKE++ TD+ M
Sbjct: 1027 QTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES--VIAEKEQL-KTDLKENIEM---- 1079
Query: 849 PLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGD 908
++ + ++G +++ + + A+K ++ + A EEK
Sbjct: 1080 ---------TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK 1130
Query: 909 VRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKI-- 966
+ Q+ + Q L +++++ E + + E + ++KN E + + + K+
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 967 ---EVEGVTRG---AVELNKSLFETTPLYAIQDPL-GKYHQVKTVQQEEIVRGDVRSCRW 1019
EV+ +T+ EL KS FET +D L G +++ + +
Sbjct: 1191 NYEEVKSITKERKVLKELQKS-FETE-----RDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 1020 LFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWL----FETQPLDSIKYFSDVEE 1075
ID+ S+ + + + I+ Q+++ + K + + E + L ++K S+ +E
Sbjct: 1245 KEHQETIDELRRSVSE-KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 1076 TESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEI-----HKGDVKTCTWL 1130
T ++ E + + K L + ME L S EEI + ++KT
Sbjct: 1304 TMNELELLTE--QSTTKDSTTLARIE-MERLRLNEKFQESQEEIKSLTKERDNLKTIKEA 1360
Query: 1131 FETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEM 1190
E + + ET K+Q + ++ Q +++ E +N + E+++ KP
Sbjct: 1361 LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK------EKDNETTKIVSEMEQFKP--- 1411
Query: 1191 DIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDK 1250
D + +R + E L S + +K + K +D+Q+ + + +++ D+
Sbjct: 1412 ----KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK-DDLQR-----LQEVLQSES-DQ 1460
Query: 1251 IKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIK----EESDYISTKKTITEEVIQ 1306
+KE+ + + K + + V C + +++E++ E+ IST + E +
Sbjct: 1461 LKENIK-EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519
Query: 1307 GDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSE 1366
+ ++E + + I+ +V +K+ + E+K L+ N+ +
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Query: 1367 TVYVIKSVTQEDIQ-----KGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTS 1421
+QE+IQ K ++ V+ + + DQ+ E + I+ +K S
Sbjct: 1580 E-------SQEEIQIMIKEKEEMKRVQEALQIE-RDQLKENTKEIV--------AKMKES 1623
Query: 1422 RQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQED 1481
++ + +++ +VNE Q+ + H ++ + L ENI+T
Sbjct: 1624 QE-------KEYQFLKMTAVNETQEKMCEIE------HLKEQFETQKLNLENIET----- 1665
Query: 1482 VQKGDVKQAVWLFENRTFDSIMEAHKGITKM---TKEEIPPSDVKTTTWLFETTPLHEFN 1538
EN I+ H+ + +M TKE V+ T +
Sbjct: 1666 -------------ENIRLTQIL--HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710
Query: 1539 ET------RVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIE-ADEIGDVRMAKYKLMNQA 1591
ET + E+++I+ +KE + + + + GI+ E +EI +++ K + +
Sbjct: 1711 ETITRDLEKQEELKIVHMHLKE-----HQETIDKLRGIVSEKTNEISNMQ----KDLEHS 1761
Query: 1592 SPEIQKEEI-IRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAE 1650
+ ++ +++ I+ +LR ++L +++ ++ I E+ ++ + L N + + E
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ-E 1820
Query: 1651 KEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIG 1710
K + +K + Q I L + +K + E K I ++ T+ + E+
Sbjct: 1821 KIQELKANEHQLI-TLKKDVNETQKKVSEMEQLKKQI---------KDQSLTLSKLEIEN 1870
Query: 1711 GDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLT 1770
++ + +H L E K ER N++ ++ D LK ES +
Sbjct: 1871 LNLAQKLHENL---------EEMKSVMKERDNLRRVEETLKL-ERDQLK----ESLQETK 1916
Query: 1771 AKKQEGEKEIIGGDVEGTKLLLKKRQSLVER---TVSETDIIPGDVHNTVKVFMTEPQST 1827
A+ E ++E+ + ++L K+ + V++ +SE I D+ + E Q
Sbjct: 1917 ARDLEIQQEL-----KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK 1971
Query: 1828 FGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQ 1887
++ K+E+ + +N + +N+ + LK E+ + +S +
Sbjct: 1972 IQELQKKELQLLRVKEDVNMSHKKINE--------------MEQLKKQFEAQNLSMQSVR 2017
Query: 1888 PD--AIPGDIEKAIECLEKATNTKTEILK-KELLK---DDLETSLRSLKEAQRSFKEVHK 1941
D + + +++E + + E+ + KE LK D +LR + R +V
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077
Query: 1942 EGVIKKDAKAVMAGSSGEQKTDIHQV 1967
E + D + + S E+ + I ++
Sbjct: 2078 EKRLLSDGQQHLTESLREKCSRIKEL 2103
Score = 53.9 bits (128), Expect = 3e-06
Identities = 198/1146 (17%), Positives = 460/1146 (40%), Gaps = 135/1146 (11%)
Query: 1176 SIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGN 1235
S + +E++E K E+ + ++ ++ + EN+ S+ + +++ KTL TE +Q+
Sbjct: 869 SYKTQELQE-KTREVQERLNEMEQLKEQLENRD------STLQTVEREKTLITEKLQQTL 921
Query: 1236 VLNCRWLFENQPIDKIKESQ--EGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDY 1293
E + +++ES E D+ + D ++ + +L+ +K+ +
Sbjct: 922 EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN--ALESLKQHQET 979
Query: 1294 ISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWL 1353
I+T K+ E + ++ ET+ + + + K + + DV+ +
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 1354 FETKPLDSI--NKSETVYVIKSVTQE------DIQKGDVSSVRYRFETQPL-DQISEESH 1404
+ + + S+ K+E +++SV E D+++ ++ + E + L D++ ++
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 1405 NIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDEL 1464
+ +H +K + S D+ + + Q+ K L M E+
Sbjct: 1100 IVAQEKNHA----IKKEGEL--SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153
Query: 1465 RGEGLEYENIKT------VTQEDVQKGDVKQAVWLFEN-RTFDSIMEAHKGITKMTKE-E 1516
+ + E EN+K +T E ++ ++ A L EN SI + K + ++ K E
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE 1213
Query: 1517 IPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADE 1576
++ E T L E ++ I + K +ET+++L + V + II
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHL--KEHQETIDEL-RRSVSEKTAQIINTQ- 1269
Query: 1577 IGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEE-KGNVNL 1635
D+ + KL + P + +E+ + +++ + ++ E E+L + K + L
Sbjct: 1270 --DLEKSHTKLQEEI-PVLHEEQELLPNVKEVSE---TQETMNELELLTEQSTTKDSTTL 1323
Query: 1636 TKTQL--LNRSTEFHAEKEEIVKGDVQQAIKNLFSEE---RSVKKGILIQEDEKGDINMT 1690
+ ++ L + +F +EEI K+L E +++K+ + ++ D+
Sbjct: 1324 ARIEMERLRLNEKFQESQEEI---------KSLTKERDNLKTIKEALEVKHDQ------- 1367
Query: 1691 IYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKI-SERAKIDASERGNVQFFTTC 1749
L E+ +T+ + + +++++ KI SE + + ++
Sbjct: 1368 ----LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR----- 1418
Query: 1750 IEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDII 1809
IE L K+L +E + K++ D++ + +L+ ++ + E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKD-------DLQRLQEVLQSESDQLKENIKEIVAK 1471
Query: 1810 PGDVHNTVKVF---MTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKG 1866
+ +KV + E + T ++ K ST+ +A+N K K +EI +
Sbjct: 1472 HLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEK 1531
Query: 1867 NMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSL 1926
+K + E + E KQ + A++ +E T L++ +++++ +
Sbjct: 1532 EEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES--QEEIQIMI 1589
Query: 1927 RSLKEAQRSFKEVHKE-GVIKKDAKAVMAGSSGEQKTD---IHQVAVQRNKNSL--LQPK 1980
+ +E +R + + E +K++ K ++A Q+ + + AV + + ++
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649
Query: 1981 PGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERT---EVNLPKAPKGTVKIVIDREQNND 2037
FE +T + + + H NL E R+ E + ++ + T+K ++R+Q +
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK--VERDQLKE 1707
Query: 2038 ALEKSLRR---------LSNSHHKSNVLESGDKTGVWTDTTGE--------QHLRDEYMS 2080
L +++ R + + H K + G+ ++ T E +H D +
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
Query: 2081 RQLTSTVSVK-NNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGF 2139
+ L ++ ++ KE + +L + + ++T +L N + +E
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKL-------------RGIVSEKTDKLSNMQKDLENS 1814
Query: 2140 HIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDI 2199
+ K +K + +K + Q + V L + Q+L + + N ++
Sbjct: 1815 NAKLQEKIQELK-ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 2200 KKK-NINLQPMWQLLPVEQDTSNVTE-MKVSEKSHNTFKATNKKRETDV--HLKSQDFLM 2255
+K + NL+ M ++ + V E +K+ K R+ ++ LK+ L
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS 1933
Query: 2256 KTNTST 2261
K + T
Sbjct: 1934 KEHKET 1939
Score = 52.8 bits (125), Expect = 6e-06
Identities = 275/1574 (17%), Positives = 609/1574 (38%), Gaps = 241/1574 (15%)
Query: 255 LAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQ 314
LA KQ E++I YQ Q + + + + ++ ++ + + +G KV
Sbjct: 658 LATTYKQMENDIQL-------YQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG-KVP 709
Query: 315 KIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQ 374
K + E+ + +E+N+ + ++ ++E VI E + +P +L KE +KS +
Sbjct: 710 KDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE 769
Query: 375 EKILYSDKE---MTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDH 431
I+ S+K+ K+ + + EE K ++T+ ++ ST Q + T + D
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 432 SVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQS-----PELPSPPRRL-PVP 485
+ + N + +++ S + F S EL + L
Sbjct: 830 EQKYKMVLEENERMN----------QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKT 879
Query: 486 KDVYSKQRNLYELNRLYKHIHPELRK-NLEKDYISEVSEIVSSQMNSGSSVSADVQQARY 544
++V + + +L ++ L+ EK I+E + ++ + + D++Q +
Sbjct: 880 REVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE 939
Query: 545 VFENTNDSSQKDL-NSEREYLEWDEILKGEVQSIRWIFENQPLDSINN-GSPDEGDISRG 602
+ D + D+ ++ ++ E L+ ++S++ Q ++IN S ++SR
Sbjct: 940 SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-----QHQETINTLKSKISEEVSRN 994
Query: 603 IADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRP 662
+ +E ++ M L A ++ T+ K E+ + R +F
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI----IEQQRKIFSL-- 1048
Query: 663 LDSMNKMHQSQEESAVTISKDITGGDVK-TVRYMFETQHLDQLGQLHSVDEVHLLQLRSE 721
+ N++ Q E +V K+ D+K + E Q E
Sbjct: 1049 IQEKNELQQMLE--SVIAEKEQLKTDLKENIEMTIENQ--------------------EE 1086
Query: 722 LKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDT 781
L+ + +K+ + + + I+ G++ E EK ++ + + Q L
Sbjct: 1087 LRLLGDELKKQQEIVAQEKNHAIKK-EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 782 INKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRK 841
+ ++++E++ + I+ EN+K + + E E+++ ++++ E++ RK
Sbjct: 1146 VQEEMSEMQ--KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203
Query: 842 CWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITA 901
+LKE+ + +R+ + G + +T E LK + K + T
Sbjct: 1204 ----------VLKELQKSFETERDHLRGYIREIEATGLQTK--EELKIAHIHLKEHQETI 1251
Query: 902 SEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFD 961
E + I TQ LE +E + E+ +VK + E+ N ++
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311
Query: 962 ASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLF 1021
+ T +E+ +
Sbjct: 1312 TEQSTTKDSTTLARIEMER----------------------------------------- 1330
Query: 1022 ETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIK-YFSDVEETESKT 1080
R ++F ES + I+ ++ + +K A + Q + I+ + ++E++SK
Sbjct: 1331 -LRLNEKFQESQEE---IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ 1386
Query: 1081 EQTRDIVKGDVKTCKWLFETQ---PMESL-----YEKVSLMTSSEEIH---------KGD 1123
EQ+ ++ + D +T K + E + P +S E + L +E H K D
Sbjct: 1387 EQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446
Query: 1124 VKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQ---GE 1180
++ + +++ D +K++ + V +EE++ V C + E ++ ++ E
Sbjct: 1447 LQRLQEVLQSES-DQLKENIKEIVAKHLETEEELK---VAHCCLKEQEETINELRVNLSE 1502
Query: 1181 EVKEIKPVEMDIQA------GDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKG 1234
+ EI ++ ++A + + K E ++ IS E+V ++K K K
Sbjct: 1503 KETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV-NELKQFKEHRKAKD 1561
Query: 1235 NVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKE----- 1289
+ L E++ ++ QE E ++ + I+ + K D++KE
Sbjct: 1562 SALQS---IESKMLELTNRLQESQEEIQIM--IKEKEEMKRVQEALQIERDQLKENTKEI 1616
Query: 1290 --------ESDYISTKKTITEEVIQG--DVKSYRMLFETQPLYAIQDREGSYHEVTTVKK 1339
E +Y K T E + +++ + FETQ L E ++
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL------ENIETENIRL 1670
Query: 1340 EEVIHGDVRGTRWLFETKPLDSINK-SETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQ 1398
+++H ++ R + TK D + ET+ V + +E++++ + + E + +
Sbjct: 1671 TQILHENLEEMRSV--TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 1399 ISEESHNIMPSIDHIQGGNVKTSRQFFESENFDK-----NNYIRTVSVNEIQKGNVKTST 1453
+E +ID ++G S + E N K N+ ++ + ++ +
Sbjct: 1729 HLKEHQE---TIDKLRG---IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782
Query: 1454 WLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFD--------SIMEA 1505
+ T+D+LRG E + + Q+D++ + K + E + + + E
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842
Query: 1506 HKGITKM--TKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKS------IKETLE 1557
K +++M K++I + + E L + +E+++ + K ++ETL+
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 1558 DLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRD 1617
+E D++ + + E++ ++ + + + L K
Sbjct: 1903 --------------LERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK-- 1946
Query: 1618 CTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEI--VKGDVQQAIKNLFSEERSVKK 1675
+E+ I IS+ +K +++ +K +L + E ++ ++ VK DV + K + +E +KK
Sbjct: 1947 ISEKTIQISDIQK-DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI-NEMEQLKK 2004
Query: 1676 GILIQEDEKGDINMTIYCL---LHENDGDTIEREEVIG--GDVKRTIHNLLSSTSNNKIS 1730
Q + M + L LHE ++E ++ D R I L + I+
Sbjct: 2005 QFEAQNLSMQSVRMDNFQLTKKLHE----SLEEIRIVAKERDELRRIKESLKMERDQFIA 2060
Query: 1731 ERAKIDASERGNVQ 1744
++ A +R N Q
Sbjct: 2061 TLREMIARDRQNHQ 2074
Score = 45.4 bits (106), Expect = 0.001
Identities = 162/915 (17%), Positives = 351/915 (38%), Gaps = 116/915 (12%)
Query: 2556 EEIEKQKQESSYYNIVKTQSQNQHITEV-EKEMPLQKTNEEVSLSGIDSECTVVQPSPGS 2614
E + K+ Q+ S + T +++ +EV KE +Q EE+ + D T
Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT-------- 808
Query: 2615 QSNARILGVCSDNQLSTTSPETVAAKRLHHVLAAS-----EDKDKMKKEVLQSSRDIMQS 2669
QSN + +T E K LH E+ ++M +E++ S++ +
Sbjct: 809 QSNYK-----------STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 2670 KSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSY 2729
S+ ++ TQ+ Q+K Q L + + + + + L T+ E + +
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV-----EREKTL 912
Query: 2730 ESHK-QQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKK-EKRVTVQLPTE 2787
+ K QQ+ +V+T T+++ K+ + S + Q ++ H + + + ++ E
Sbjct: 913 ITEKLQQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 2788 SIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNK 2847
S++++QE + + E S + + E K++ +++++ K + L+ K
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE-------FQQKMVGIDKKQDLEAK 1024
Query: 2848 SAPKVVKQKVIDAHLDSQTQNFQQTQ-----IQTAESKAEHKKLPQPYNSLQEEKCLEVK 2902
+ + + ++ Q + F Q Q ES K+ Q L+E + ++
Sbjct: 1025 NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE--QLKTDLKENIEMTIE 1082
Query: 2903 GIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKR-----EELQQI 2957
+E ++ + +QEI + + KE + L VE K +E QQ
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
Query: 2958 LSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKT 3017
L V++ +E K + + L N + ++ + E + + L + EE+ I T
Sbjct: 1143 LLNVQEEMSEMQKK-INEIENLKNELKNKELTLEHME-TERLELAQKLNENYEEVKSI-T 1199
Query: 3018 QAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLD-ETSSKVSNVHVSNNKNSEQKENKIAK 3076
+ +L + +T + + T L + K++++H+ ++ + + +
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 3077 EKTVQHQVAAHHEATVRSHVKTHQEIKL--DDSNIPPPSLKTRPPSPT-----FITIEST 3129
EKT Q + + +SH K +EI + ++ + P + T +T +ST
Sbjct: 1260 EKTAQ---IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST 1316
Query: 3130 ARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTT 3189
+ + + E+ + + + E K + + + +++T
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL 1376
Query: 3190 AKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAAS 3249
AK+ + K+ + + KI + P + + I
Sbjct: 1377 AKIQESQ------------SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 3250 GSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHT 3309
G + ++ +E++ V K KD L ++ +ES E I+++ +++H
Sbjct: 1425 GLSKRLQESHDEMKSVAK-----EKDDLQRLQEVL-QSESDQLKENIKEI-----VAKHL 1473
Query: 3310 QRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESR 3369
+ E +++A + + E IN + +++ A + N QE
Sbjct: 1474 ETEE----ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE-- 1527
Query: 3370 TFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQI 3429
+ KEE F+ K E++EK+ +E + EH D+ Q
Sbjct: 1528 IYEKEE------------QFNIKQISEVQEKV--------NELKQFKEHRKAKDS-ALQS 1566
Query: 3430 VESKMKTSSSHSSEA 3444
+ESKM ++ E+
Sbjct: 1567 IESKMLELTNRLQES 1581
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 61.6 bits (148), Expect = 1e-08
Identities = 47/154 (30%), Positives = 65/154 (42%), Gaps = 31/154 (20%)
Query: 2286 ECPLPPPSP----PPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESF 2341
+ PL SP PP PP+ + + + P PPPPP+ G PS+ E +
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPV-------GNRPSIHREAVP------ 283
Query: 2342 PGLPLPPPPVDEK-----SERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQY 2396
PPPP + K + R S+S PPPPPP P L P D +
Sbjct: 284 -----PPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPL----PPSSSGNDETPRL 334
Query: 2397 SQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLP 2430
Q+ S S ++ G++G LPPP +P P
Sbjct: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPP 368
Score = 54.7 bits (130), Expect = 2e-06
Identities = 43/153 (28%), Positives = 58/153 (37%), Gaps = 24/153 (15%)
Query: 2290 PPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPP 2349
PPPS PPPP PLPPPPP+ + LP+ ++ +S P PP
Sbjct: 359 PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPL 418
Query: 2350 PVDEKSERESSSMFLPPPPPPTPSQKPA----------------HLLSSSAPEKHSGDFM 2393
P D S PPPPPP+ S + H +S P +
Sbjct: 419 PPDRPSAG------APPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTT 472
Query: 2394 QQYSQKEASNSQNSQAKIITGKTGVLPPPTLPK 2426
+ Y K A N S + + G P P +P+
Sbjct: 473 KSYPSKLARNESRSGSN--RRERGAPPLPPIPR 503
Score = 43.1 bits (100), Expect = 0.005
Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 21/107 (19%)
Query: 2283 KESECPLPPPSPPPPPPS----NASSEIEFPLPP-----PPPLMMFPEKNGFLPSLSTEK 2333
+E+ P PP + PP PS +ASS+ P PP PPPL N P L
Sbjct: 279 REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRN 338
Query: 2334 IKAEFESFPGLPLP------PPPVDEK-----SERESSSMFLPPPPP 2369
+ S P LP P PPP E+ + S LPPPPP
Sbjct: 339 LSLS-SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPP 384
Score = 43.1 bits (100), Expect = 0.005
Identities = 37/122 (30%), Positives = 47/122 (38%), Gaps = 30/122 (24%)
Query: 2285 SECPLPPPSP----PPPPPSNASSEIEFPLPPP---------PPLMMFPEKNGFLPSLST 2331
S+ P PPP P PPP P ++S E P P PPL P ++G LP +
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-PGRSGPLPPPPS 362
Query: 2332 EKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPP----------------PPTPSQK 2375
E+ PG P PP S S+S LP P PP P +
Sbjct: 363 ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDR 422
Query: 2376 PA 2377
P+
Sbjct: 423 PS 424
Score = 32.7 bits (73), Expect = 6.6
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 3/100 (3%)
Query: 3110 PPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVE---PPPRRPMSQKSEIH 3166
PPP R + +I + + +P N P ++ PPP P+ + IH
Sbjct: 219 PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIH 278
Query: 3167 RANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVP 3206
R P PP++ + +A P P + P P
Sbjct: 279 REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 61.6 bits (148), Expect = 1e-08
Identities = 47/154 (30%), Positives = 65/154 (42%), Gaps = 31/154 (20%)
Query: 2286 ECPLPPPSP----PPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESF 2341
+ PL SP PP PP+ + + + P PPPPP+ G PS+ E +
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPV-------GNRPSIHREAVP------ 283
Query: 2342 PGLPLPPPPVDEK-----SERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQY 2396
PPPP + K + R S+S PPPPPP P L P D +
Sbjct: 284 -----PPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPL----PPSSSGNDETPRL 334
Query: 2397 SQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLP 2430
Q+ S S ++ G++G LPPP +P P
Sbjct: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPP 368
Score = 54.7 bits (130), Expect = 2e-06
Identities = 43/153 (28%), Positives = 58/153 (37%), Gaps = 24/153 (15%)
Query: 2290 PPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPP 2349
PPPS PPPP PLPPPPP+ + LP+ ++ +S P PP
Sbjct: 359 PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPL 418
Query: 2350 PVDEKSERESSSMFLPPPPPPTPSQKPA----------------HLLSSSAPEKHSGDFM 2393
P D S PPPPPP+ S + H +S P +
Sbjct: 419 PPDRPSAG------APPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTT 472
Query: 2394 QQYSQKEASNSQNSQAKIITGKTGVLPPPTLPK 2426
+ Y K A N S + + G P P +P+
Sbjct: 473 KSYPSKLARNESRSGSN--RRERGAPPLPPIPR 503
Score = 43.1 bits (100), Expect = 0.005
Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 21/107 (19%)
Query: 2283 KESECPLPPPSPPPPPPS----NASSEIEFPLPP-----PPPLMMFPEKNGFLPSLSTEK 2333
+E+ P PP + PP PS +ASS+ P PP PPPL N P L
Sbjct: 279 REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRN 338
Query: 2334 IKAEFESFPGLPLP------PPPVDEK-----SERESSSMFLPPPPP 2369
+ S P LP P PPP E+ + S LPPPPP
Sbjct: 339 LSLS-SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPP 384
Score = 43.1 bits (100), Expect = 0.005
Identities = 37/122 (30%), Positives = 47/122 (38%), Gaps = 30/122 (24%)
Query: 2285 SECPLPPPSP----PPPPPSNASSEIEFPLPPP---------PPLMMFPEKNGFLPSLST 2331
S+ P PPP P PPP P ++S E P P PPL P ++G LP +
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-PGRSGPLPPPPS 362
Query: 2332 EKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPP----------------PPTPSQK 2375
E+ PG P PP S S+S LP P PP P +
Sbjct: 363 ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDR 422
Query: 2376 PA 2377
P+
Sbjct: 423 PS 424
Score = 32.7 bits (73), Expect = 6.6
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 3/100 (3%)
Query: 3110 PPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVE---PPPRRPMSQKSEIH 3166
PPP R + +I + + +P N P ++ PPP P+ + IH
Sbjct: 219 PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIH 278
Query: 3167 RANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVP 3206
R P PP++ + +A P P + P P
Sbjct: 279 REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 60.5 bits (145), Expect = 3e-08
Identities = 157/848 (18%), Positives = 320/848 (37%), Gaps = 142/848 (16%)
Query: 2314 PPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
PP P G SLS+ K S LP +EKSE + + P PT S
Sbjct: 278 PPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGS 337
Query: 2374 QKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHI 2433
+ PA APE + D ++ S++E + + PK K +
Sbjct: 338 E-PAKASEKEAPE-DTVDAGEEGSRREEAAKE-------------------PKKK-ASAL 375
Query: 2434 KDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSL------- 2486
++ +D S ++E++ + + + + + D K + + ++++ +
Sbjct: 376 EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGG 435
Query: 2487 ---DERKQLSI----DSANCLSHTVPGTSAPRKKQIAPLI----KSHSFPESSGQQNPKP 2535
++ L I DS + S +++++P + ++ S P S + P
Sbjct: 436 ACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPP 495
Query: 2536 Y----MRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQK 2591
++K + E+ ++ Q++++ + + QH ++ E+ P Q+
Sbjct: 496 QGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQH-SQAEELGPGQE 554
Query: 2592 TNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASED 2651
E+ E V P+P R S E VA A
Sbjct: 555 EAED------PEEKVAVSPTPPVSPEVR-------------STEPVAPPEQLSEAALKAM 595
Query: 2652 KDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVK 2711
++ + + + Q R +++SK E Q +E Q+ ++ E L L Q K S
Sbjct: 596 EEAVAQVLEQDQRHLLESKQ--EKMQQLREKLCQEEEE----EILRLHQQKEQS------ 643
Query: 2712 TIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHY 2771
L +L L + E+ ++ E ++ + Q ++ST+ Q AE+
Sbjct: 644 ---LSSLRERLQKAIEEEEARMREEESQRLSWLRAQ------VQSSTQADEDQIRAEQEA 694
Query: 2772 QLPKKEKRVTVQLPTE--SIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEK---NQGPS 2826
L K + + Q E S+++ L+ + + S++ L ++EK
Sbjct: 695 SLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 754
Query: 2827 MIGRKEERLIT-ERKHE-HLKNKSAPKVVKQKVIDAHLDSQTQNFQQ---TQIQTAESKA 2881
+ G ++E + T E++H L+ + K + + + L + Q QQ Q+Q +
Sbjct: 755 LEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQV 814
Query: 2882 EHKKLPQPY---------NSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKE 2932
EH+ + Y +SL EK EV+G E+++ ++ +Q + + + + + +
Sbjct: 815 EHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEER 874
Query: 2933 SQRDDGKGAL-----------------------NIVEFLRKREELQQILSRVKQFEAEPN 2969
QR + G L +E LR+R Q+ + + + E
Sbjct: 875 KQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETR 934
Query: 2970 KSGLKTFQTLLNTIPGWLISED--KREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYE 3027
+K LL + E+ +RE + ++ + EE T Q E+ +
Sbjct: 935 AKDVKARLALLE------VQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHT 988
Query: 3028 NIIQT-----AMMSSKTGKPGNKPTSLD--ETSSKVSNVHVSNNKNSEQKENKIAKEKTV 3080
+++Q+ ++ + + +D + S+ H S+ + QK+ + +E TV
Sbjct: 989 HLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTV 1048
Query: 3081 QHQVAAHH 3088
+ A+ H
Sbjct: 1049 EENNASPH 1056
Score = 47.4 bits (111), Expect = 3e-04
Identities = 123/634 (19%), Positives = 246/634 (38%), Gaps = 92/634 (14%)
Query: 1588 MNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEF 1647
+ P E++ A L+ + + + +R +L S++EK QL + +
Sbjct: 575 VRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEK------MQQLREKLCQ- 627
Query: 1648 HAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDE-KGDINMTIYCLLHENDGDTIERE 1706
E+EEI++ QQ ++L S ++K I +E + + + + L + T E
Sbjct: 628 -EEEEEILRLH-QQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADE 685
Query: 1707 EVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESN 1766
+ I + + ++ L + + +ERA ++ R ++ IEA L+
Sbjct: 686 DQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKE 745
Query: 1767 ETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQS 1826
+ L Q+ +++ G E L K+ + +ER S + +V ++++ + E Q
Sbjct: 746 KAL----QQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ 801
Query: 1827 TFGKIPKEEIIKGDLTSTLNSLSQAVNQKT-------------VTKTEEIIKGNMLATLK 1873
KEE L L + V+QK+ + + + ++G L
Sbjct: 802 ------KEE---AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD 852
Query: 1874 SLKE----------SSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLE 1923
+KE + +E KQ + G + +E L++A + E +++E K LE
Sbjct: 853 KMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHK-RLE 911
Query: 1924 TSLRSLKEAQRSFKEVHKEGVIK-KDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPG 1982
R +E +R +++ + + KD KA +A ++ + +R K LL +
Sbjct: 912 DLRRRHREQERKLQDLELDLETRAKDVKARLA------LLEVQEETARREKQQLLDVQR- 964
Query: 1983 PFEPAAKWQGGADTLSQ-TMGKSCHGNLVEERTEVN--LPKAPKGTVKIVIDREQNNDAL 2039
+ A K + T Q + H +L++ ++ L + +K+ E D L
Sbjct: 965 --QVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKL----ESQVDLL 1018
Query: 2040 EKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQ-----------HLRDEYMSRQLTSTVS 2088
+ ++L H S E+ K + + T E+ H+ D S T
Sbjct: 1019 QAQSQQL-QKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKE 1077
Query: 2089 VKNNLTTKESDRAVRELKKDDVFNSIQSAG------KTVGKQQTYELRNDHQKMEGFH-- 2140
V ++L+ + D + L +V++ + + G K QQT +R ++
Sbjct: 1078 VSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQH 1137
Query: 2141 --------IKSPKKTKNIKILTDTQSSKPSPTQH 2166
+ K IK L D + + T+H
Sbjct: 1138 WRHELASAQEVAKDPPGIKALEDMRKNLEKETRH 1171
Score = 33.1 bits (74), Expect = 5.0
Identities = 59/283 (20%), Positives = 112/283 (39%), Gaps = 41/283 (14%)
Query: 2850 PKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGI--QEK 2907
P+ + + + A ++ Q +Q Q ESK E K+ Q L +E+ E+ + Q++
Sbjct: 584 PEQLSEAALKAMEEAVAQVLEQDQRHLLESKQE--KMQQLREKLCQEEEEEILRLHQQKE 641
Query: 2908 QVFSNTKDSKQEITQNKSFFSSVKESQR---------------DDGKGALNIVEFLRKRE 2952
Q S+ ++ Q+ + + +ESQR +D A + RE
Sbjct: 642 QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLRE 701
Query: 2953 ELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEI 3012
EL+ S+ K A + + + L I SE + A++ A E L++++E++
Sbjct: 702 ELE---SQQKAERASLEQKNRQMLEQLKEEIEA---SEKSEQAALNAAKEKALQQLREQL 755
Query: 3013 THIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKEN 3072
+ +A L + + SS K +SL + + + K Q +
Sbjct: 756 EGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQK------KIQEAQQKEEAQLQK 809
Query: 3073 KIAKEKTVQHQVAAH-----HEAT-----VRSHVKTHQEIKLD 3105
+ + + HQ + H HE + R V+ E +LD
Sbjct: 810 CLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD 852
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 60.5 bits (145), Expect = 3e-08
Identities = 380/2156 (17%), Positives = 810/2156 (37%), Gaps = 358/2156 (16%)
Query: 213 LHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPG-GLAKVKKQFEDEITSSRN 271
L E+ +E +A + + ++++ EM + G G+A +K + E T
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQ-- 620
Query: 272 TFAQYQYQHQNRSEQEAIHSSQVGT---SRSSQEMARNEQEGSKVQKIDVHGTEMVSHLE 328
+ S A+ Q T SR+S+E++ N+ G +++ G +
Sbjct: 621 ---DFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDA-GVELKSTKQDG-------D 669
Query: 329 KHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPA 388
K V Q HQ +E+ ++ +++L+ + ++I +K + A
Sbjct: 670 KSLSAVPDIGQCHQ------------DELERLKSQILELELNFHKAQEIY--EKNLDEKA 715
Query: 389 KQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGM 448
K+I ++ E FK ++ +S++ + S+ ++ ++ + S+ + AQ+ +
Sbjct: 716 KEISNLNQLIEEFKKNA--DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNL 773
Query: 449 TEEFPPPPPDV-LQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHP 507
E D QT+ D Q L + V +V + + +L
Sbjct: 774 AEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF------- 826
Query: 508 ELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWD 567
+ + + + S N S V ++ R++ + SQ E E + D
Sbjct: 827 -------SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879
Query: 568 EIL---KGEVQSIRWIFE--NQPLDSINNGSPD------EGDISRGIADQEIIAGGDVKY 616
++L K +V++++ E +Q + I+ + E S G+ + + ++
Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS 939
Query: 617 TTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEES 676
+ + ++ SS +N +++ G + E L N+ + + ++
Sbjct: 940 RAEEAKKEQVEEDNEVSSGLKQNYDEMSPA--GQISKEELQHEFDLLKKENEQRKRKLQA 997
Query: 677 AVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQL-RSELKEIKGNVKRSIKC 735
A+ K++ + R E +L S E+ L + R E++E K N + S KC
Sbjct: 998 ALINRKELLQ---RVSRLEEELANLKD----ESKKEIPLSETERGEVEEDKENKEYSEKC 1050
Query: 736 FETQ----PLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKV 791
++ +Y+ + S + +E++ + ++ EK Q T+ +I +
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 792 VRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGT------DVSRKCWMF 845
++ + EN + + + +E ++ G+ ++ K
Sbjct: 1111 LQA-EISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169
Query: 846 ETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQK-ITASEE 904
E + + K++ +A + R+ I+ + +HL E L + D +LQ+ +
Sbjct: 1170 EKEKEQLQKKLQEALT-SRKAILKKAQEKERHLREELK----QQKDDYNRLQEQFDEQSK 1224
Query: 905 EKGDVRHQKWIFETQPLEDI------RKDKKEYTRTVKLEE-VDRGDVKNYTHIFESNNL 957
E ++ Q + Q E I ++ + T LEE + + +++T +NL
Sbjct: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
Query: 958 IKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEI---VRGDV 1014
SH + + G T + I+ Q+K ++ E++ ++
Sbjct: 1285 CPDWPSHSEDASALQGG-----------TSVAQIKA------QLKEIEAEKVELELKVSS 1327
Query: 1015 RSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGN------VKSAKWLFETQPLDSIK 1068
+ ++ + Q E I+K +G+ + ++T + +S + E+ L I
Sbjct: 1328 TTSELTKKSEEVFQLQEQINK----QGLEIESLKTVSHEAEVHAESLQQKLESSQLQ-IA 1382
Query: 1069 YFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTS--SEEIHKGD-VK 1125
+ E + K ++ + ++ + +L L EK + +T +E I + D +K
Sbjct: 1383 GLEHLRELQPKLDELQKLISKKEEDVSYL-----SGQLSEKEAALTKIQTEIIEQEDLIK 1437
Query: 1126 TCTWLFETQPLDTIKDDSETAVKLQTVKQ--EEIQGGDVRTACFLFETENLDSIQGEEVK 1183
E Q + + + V+L +KQ EEI GEE +
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI---------------------GEESR 1476
Query: 1184 EIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKI--------KTLKTEDIQKGN 1235
+ ++ +QA +S EN+SL S + ++++ + ++ +K
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 1236 VLN----------------CRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIF 1279
VL R L ENQ + ES +K + D K
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCES------LKLALEGLTEDKEKLVKEI 1590
Query: 1280 ETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKK 1339
E+ +I E +++ K + +E Y +L ++ + + E H V V++
Sbjct: 1591 ESLKSSKIAESTEWQEKHKELQKE--------YEILLQSYENVS-NEAERIQHVVEAVRQ 1641
Query: 1340 E-EVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQ 1398
E + ++G +R T NK ET ++ QE + + + + Q + +
Sbjct: 1642 EKQELYGKLRST----------EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Query: 1399 ISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFET 1458
+ EE+ + + H G K + S N + V + E + + K + + E
Sbjct: 1692 LEEENDRLRAEV-HPAGDTAKECMETLLSSNASMKEELERVKM-EYETLSKKFQSLMSEK 1749
Query: 1459 HTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIP 1518
++ E E +++K + +V K +A +N+T +T+ + IP
Sbjct: 1750 DSLSE------EVQDLKHQIEGNVSKQANLEATEKHDNQT---------NVTEEGTQSIP 1794
Query: 1519 PSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIG 1578
+ + T P T E + + +D S I + + D++
Sbjct: 1795 GETEEQDSLSMSTRP------TCSESVPSAKSANPAVSKDFSSHDEIN--NYLQQIDQLK 1846
Query: 1579 DVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKT 1638
+ R+A + E QK + L N LLS+ + E+ + +EE +NL
Sbjct: 1847 E-RIAGLE------EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 1639 QL---LNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTI--YC 1693
Q+ L+R T+ EE K D+++ + N +E +N +I YC
Sbjct: 1900 QIQEELSRVTKLKETAEE-EKDDLEERLMNQLAE-----------------LNGSIGNYC 1941
Query: 1694 LLHENDGDTIEREEVIGGDVK--RTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIE 1751
++ D + E++ ++K + + L + E+ K+++ R + + I+
Sbjct: 1942 ---QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR---KEYLEKIQ 1995
Query: 1752 AGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPG 1811
+ + H + + L +KQ+ K++ + + +++ S +ERTV + +
Sbjct: 1996 GAQKEPGNKSHAKELQELLKEKQQEVKQL-----QKDCIRYQEKISALERTVKALEFV-- 2048
Query: 1812 DVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLAT 1871
TE Q +I KE + + + + ++ + K + + +LA
Sbjct: 2049 ---------QTESQKDL-EITKENLAQA-VEHRKKAQAELASFKVLLDDTQSEAARVLAD 2097
Query: 1872 LKSLKESSHRWKES-----KQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSL 1926
LK+ KES KQ D D+E+ +E E + + +K+ +++ L+
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQKDE---DLERRLEQAE-----EKHLKEKKNMQEKLDALR 2149
Query: 1927 RSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEP 1986
R + + E+ + + K K V T A ++ +SL + +
Sbjct: 2150 REKVHLEETIGEI--QVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
Query: 1987 AAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRL 2046
A KW+ + + + E+ L + +K + Q + +E+ +
Sbjct: 2208 AKKWE-----------RKFSDAIQSKEEEIRLKEDNCSVLKDQL--RQMSIHMEELKINI 2254
Query: 2047 SNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTV--------SVKNNLTTKES 2098
S H + ES +T V L+ E +++L S + S +N L ES
Sbjct: 2255 SRLEHDKQIWESKAQTEVQLQQKVCDTLQGE--NKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 2099 DRAVRELKKDDVFNSIQSAGKTVG------KQQTYELRNDHQKMEGFHIKSPKKTKNIKI 2152
+ + + D+ NS++ + G +QQ +++N E ++
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE-------------QL 2359
Query: 2153 LTDTQSSK--PSPTQHPVSMPVGGTYDLSGDFQK--QTLLKQETKYSNKDIKKKNINLQP 2208
TD Q+S+ S ++M L ++ Q + + + +K+IK+
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE------- 2412
Query: 2209 MWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLK 2264
+ LL E++ + V E E++ TN+ ET +K ++ K + +K
Sbjct: 2413 LENLLSQEEEENIVLE----EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
Score = 55.5 bits (132), Expect = 9e-07
Identities = 127/703 (18%), Positives = 281/703 (39%), Gaps = 86/703 (12%)
Query: 2446 LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVIS---KSLDERKQLSIDSANCLSH 2502
L SL+D+E +++ +K ++ + E + +I+ +SL E + LS S L
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS-SSCESLKL 1574
Query: 2503 TVPGTSAPRKKQIAPL--IKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIE- 2559
+ G + ++K + + +KS ES+ Q ++K L+ + E + E I+
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
Query: 2560 -----KQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGS 2614
+Q+++ Y + T++ + E E LQ+ +E+ + + + + +
Sbjct: 1635 VVEAVRQEKQELYGKLRSTEANKK-----ETEKQLQEAEQEME----EMKEKMRKFAKSK 1685
Query: 2615 QSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACE 2674
Q L +D + P AK L +S K + E ++ + + K +
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF--Q 1743
Query: 2675 IKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYES--- 2731
S ++ +++ Q K+ + ++ + + K D+ N T+ +S
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH--------DNQTNVTEEGTQSIPG 1795
Query: 2732 -HKQQSEIDVQT----FTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPT 2786
++Q + + T K+ S + S + Q+ + ++R+
Sbjct: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL--E 1853
Query: 2787 ESIQKNQEDKLKMVPRKQREFS--GSDRGKLPGSEEKNQGPSMIGRK-EERL--ITERKH 2841
E QKN+E + K S + G+L +E+ +++ ++ +E L +T+ K
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 2842 --EHLKNKSAPKVVKQKV-IDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKC 2898
E K+ +++ Q ++ + + Q+ QI+ ++E K L + + L+EEK
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Query: 2899 LEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQIL 2958
VK + +K E K + ++ +Q++ G + +ELQ++L
Sbjct: 1974 QLVK-----------EKTKVESEIRKEYLEKIQGAQKEPGNKS--------HAKELQELL 2014
Query: 2959 SRVKQFEAEPNKSGLK---TFQTLLNTIPGWLISEDKREYAVHIAMEN------NLEKVK 3009
+Q + K ++ L T+ + + + + I EN + +K +
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
Query: 3010 EEITHIK-----TQAEDMLVSYENI-IQTAMMSSKTGKPGN---KPTSLDETSSKVSNVH 3060
E+ K TQ+E V +N+ ++ + S+K K L+ + H
Sbjct: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
Query: 3061 VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIK 3103
+ KN ++K + + +EK + + T+ K Q+++
Sbjct: 2135 LKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ 2177
Score = 53.1 bits (126), Expect = 5e-06
Identities = 411/2270 (18%), Positives = 890/2270 (39%), Gaps = 374/2270 (16%)
Query: 201 EDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKK 260
E+ + G + L E ++L R + D S+ + + + + G ++K +
Sbjct: 919 EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED-NEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 261 QFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHG 320
Q E ++ N + + Q + +E + SR +E+A + E K +I +
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQR----VSRLEEELANLKDESKK--EIPLSE 1031
Query: 321 TEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQF-EKSAQEKILY 379
TE EV + + +Y ++ V ++ EI LK+ EK + + +
Sbjct: 1032 TER--------GEVEEDKENKEYSEKCVTSKCQEIEI------YLKQTISEKEVELQHIR 1077
Query: 380 SDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLA 439
D E +++ E +++ K + T+ + Q + + +TS+T A
Sbjct: 1078 KDLE-----EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDA 1132
Query: 440 QINATSSGMTEEFPPPPPDVLQTSVDVTAFSQ--SPELPSPPRRLPVPKD---------V 488
+ + + E PP T S+ PEL L K+ +
Sbjct: 1133 SDGDSVALVKETVVISPP--------CTGSSEHWKPELEEKILALEKEKEQLQKKLQEAL 1184
Query: 489 YSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFEN 548
S++ L + +H+ EL++ +KD + + E Q ++ ++Q +
Sbjct: 1185 TSRKAILKKAQEKERHLREELKQ--QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE 1242
Query: 549 TND-----SSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGI 603
+ D + Q++ S LE E + + E+ + S D + G
Sbjct: 1243 SIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGT 1302
Query: 604 ADQEIIA--------------------GGDVKYTTWMFETQP--------IDTLGAYSSD 635
+ +I A K + +F+ Q I++L S +
Sbjct: 1303 SVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHE 1362
Query: 636 TVENAEKIP---ELARGDVCTARWMFETRP-LDSMNKMHQSQEESAVTISKDITGGDVKT 691
+AE + E ++ + + E +P LD + K+ +EE +S ++ +
Sbjct: 1363 AEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 692 VRYMFET-QHLDQLGQLHSVDEVH-------LLQLRSELKEIK------GNVKRSIKCFE 737
+ E + D + LH+ E+ + QL+ EL E+K G R+ + +
Sbjct: 1423 TKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQ 1482
Query: 738 TQPLYVIRDGSGQMLEIKTVHRE-DVEKGDV-RTARWMFETQP-LDTINKDITEIKVVRG 794
+ + + E K++ E + +G + R + + + + + NK+ +
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 795 ISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIE-----KEKIIGTDVSRKC------- 842
+ EE K + L E Q L ES ++ +E KEK++ S K
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 843 -WMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITA 901
W + + L E+ LQ E + + + +H+ E + E + GKL+ A
Sbjct: 1603 EWQEKHKELQKEYEI----LLQSYENVSNEAERIQHVVEAVRQEKQEL---YGKLRSTEA 1655
Query: 902 SEEEKGDVRHQKWIFET-QPLEDIRKDKKEYTRTV--KLEEVDRGDVKNYTHIFESNN-- 956
+++E +K + E Q +E++++ +++ ++ K+ E++ + + + + +
Sbjct: 1656 NKKET-----EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA 1710
Query: 957 ------LIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIV 1010
L+ +AS K E+E V L+K L + +D L + +V+ ++ + +
Sbjct: 1711 KECMETLLSSNASMKEELERVKMEYETLSKKF---QSLMSEKDSLSE--EVQDLKHQ--I 1763
Query: 1011 RGDVRSCRWLFETRPID-QFDESIHKFQIIRG---------ISAQEIQTGNVKSAKWLFE 1060
G+V L T D Q + + Q I G +S + + +V SAK
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 1061 T---------------QPLDSIKY-FSDVEETESKTEQTRDIVKGDVKTCKWLFETQP-- 1102
Q +D +K + +EE + K ++ ++ + T T+
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 1103 MESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDV 1162
++ L E+V+ M + + ++ T L ET + KDD E + Q E+ G
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE--KDDLEERLMNQLA---ELNGSIG 1938
Query: 1163 RTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKK 1222
+ + + + + E+K +K +++ ++ K + +S +E L+K
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES-----EIRKEYLEK 1993
Query: 1223 IKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETF 1282
I+ + E K + + L + + ++K+ Q+ +C++ I
Sbjct: 1994 IQGAQKEPGNKSHAKELQELLKEKQ-QEVKQLQK--DCIRYQEKIS-------------- 2036
Query: 1283 SLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEV 1342
+L+ + +++ T+ E+ + ++ A++ R+ + E+ + K V
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQ-----------AVEHRKKAQAELASFK---V 2082
Query: 1343 IHGDVRG--TRWLFETKPLDSINKSETVYVIKSVTQED------IQKGDVSSVRYRFETQ 1394
+ D + R L + L +S V + Q+D +++ + ++ + Q
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
Query: 1395 P-LDQISEESHNIMPSIDHIQGGNVKTSRQFFE-SENFDKN-----NYIRTVSVNEIQKG 1447
LD + E ++ +I IQ K ++ + EN D + +++S + +
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRD 2202
Query: 1448 NVKTSTWLFETHTMDELRGEG----LEYENIKTVT----QEDVQKGDVKQAVWLFEN--R 1497
V +E D ++ + L+ +N + Q + ++K + E+ +
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 1498 TFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLE 1557
++S + + + + + + + + L ET L+ ++ + K+E KS+K+ L
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
Query: 1558 DLYS--QKVIQAPGII--IEADEIGDVRMAKYKLMN-----QASPEIQK---EEIIRADL 1605
DL + +K + G + I + D++ +K+ QAS E+ EEI +
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQ 2382
Query: 1606 RNIMVNLLS-----------------KRDCTEREILISEEEKGNVNLTK--TQLLNRSTE 1646
+ +++LLS ++ E E L+S+EE+ N+ L + + ++++ +
Sbjct: 2383 K--IISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ 2440
Query: 1647 FHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTI-ER 1705
+ I K ++QQ + + VK +Q D D + Y L E I E+
Sbjct: 2441 LMETLKTIKKENIQQKAQ----LDSFVKSMSSLQNDR--DRIVGDYQQLEERHLSIILEK 2494
Query: 1706 EEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTES 1765
+++I ++ NNK+ E + S ++ ++A + Y + L
Sbjct: 2495 DQLIQE----------AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL---- 2540
Query: 1766 NETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQ 1825
N+ +T K + +K+++ ++ K L K L E+ + E++ D+ + E Q
Sbjct: 2541 NQVITIKDSQ-QKQLLEVQLQQNKELENKYAKLEEK-LKESEEANEDLRRSFNALQEEKQ 2598
Query: 1826 STFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKT---EEIIKGNMLATLKSLKESSHRW 1882
DL+ + SL +++Q T T EE G A LK +E HR
Sbjct: 2599 --------------DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 1883 KE--SKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVH 1940
S I ++E+ + C++K K ++D L+ L+ L H
Sbjct: 2645 SALFSSSQKRI-AELEEELVCVQKEAAKKV-----GEIEDKLKKELKHLH---------H 2689
Query: 1941 KEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQT 2000
G+++ + + ++ E+ ++ + V+ + L+ K A+ Q ++S
Sbjct: 2690 DAGIMRNETE-----TAEERVAELARDLVEMEQKLLMVTKENK-GLTAQIQSFGRSMSSL 2743
Query: 2001 MGKSCHGN----LVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVL 2056
H N ++ + + +L + + + +++RE+ DAL S S + + N L
Sbjct: 2744 QNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER--DAL-LSETAFSMNSTEENSL 2800
Query: 2057 ESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQS 2116
+K + EQ L ++S QL + N + + A + ++D ++N ++
Sbjct: 2801 SHLEKLNQQLLSKDEQLL---HLSSQLEDSY---NQVQSFSKAMASLQNERDHLWNELEK 2854
Query: 2117 AGKT-VGKQQT--------YELRNDHQKMEGFHIKSPKKTKNIKILTD--TQSSKPSPTQ 2165
K+ GKQ++ E+++ + M + K +K L Q ++
Sbjct: 2855 FRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITEL 2914
Query: 2166 HPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEM 2225
HP+ + D + FQ + QE +++++N++ Q L +E+ + + E
Sbjct: 2915 HPLKAQLQEYQDKTKAFQ----IMQE------ELRQENLSWQHELHQLRMEKSSWEIHER 2964
Query: 2226 KVSEKSHNTFKATNKKRETDVHLKS--QDFLMKTNTSTGLKMAMERSLNP 2273
++ E+ A + K + HL++ ++ ++ + LK+ +R +P
Sbjct: 2965 RMKEQ---YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASP 3011
Score = 51.6 bits (122), Expect = 1e-05
Identities = 104/532 (19%), Positives = 212/532 (39%), Gaps = 110/532 (20%)
Query: 2625 SDNQLSTTSPETVAAKRLHHVLAASEDKD---------KMKKEVLQSSRDIMQSKSACEI 2675
SD + + T+ E V + + E KD + K E LQ R +K I
Sbjct: 38 SDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK----I 93
Query: 2676 KQSHQECSTQQTQQKKYLEQLHL---------PQSKP-ISPNFKVKT---IKLPTLDHTL 2722
K+ + T KY+E++ PQS+ +S + K T +++ + H L
Sbjct: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
Query: 2723 NETDH-----------SYESHKQQSEIDVQTFTK-KQYLKTKKTEAST-ECSHKQSLAER 2769
E + + QS +++ F KQ L+ K+ ST + Q+ AE+
Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 213
Query: 2770 HYQLPKKEKRVT------------VQLPTES-IQKNQEDKLKMVPRKQREFSGSDRGK-- 2814
Q +EK +QL T++ ++ + KL+++ RK E S G+
Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
Query: 2815 --------LPGSEEKNQGPSMIGRKEERLITERKHEHLKN-----KSAPKVVKQKV---- 2857
L +E++NQ ++ ++ +++ E +H L+N + K++ +K+
Sbjct: 274 VVDLLQQELTAAEQRNQ---ILSQQLQQM--EAEHNTLRNTVETEREESKILLEKMELEV 328
Query: 2858 ---------IDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEK- 2907
+ + + F+Q AE ++ + L Q + + EEK + +Q+
Sbjct: 329 AERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTG 388
Query: 2908 QVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKRE-ELQQILSRVKQFEA 2966
Q + D+ ++ QN +D + A+ + +++ E +LQQ + QF
Sbjct: 389 QELQSACDALKD--QNSKLL-------QDKNEQAVQSAQTIQQLEDQLQQKSKEISQF-- 437
Query: 2967 EPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSY 3026
N+ L+ +T T D E N+ +++ + ++ + +L+S
Sbjct: 438 -LNRLPLQQHETASQT-----SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 491
Query: 3027 ENIIQTAMMSSKTG------KPGNKPTSLDETSSKVSNVHVSNNKNSEQKEN 3072
+ + + K + N+ D S++S V ++N ++S +E+
Sbjct: 492 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEES 543
Score = 51.2 bits (121), Expect = 2e-05
Identities = 121/683 (17%), Positives = 285/683 (41%), Gaps = 96/683 (14%)
Query: 2477 TKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPY 2536
TK+N ++++++ RK+ + A+ + T + + +A +K +S+ +++ K
Sbjct: 2059 TKEN-LAQAVEHRKKAQAELAS-FKVLLDDTQSEAARVLADNLKLKKELQSN-KESVKSQ 2115
Query: 2537 MRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEV--EKEMPLQKTNE 2594
M++ L E+ +Q EE +++++ + + + H+ E E ++ L K ++
Sbjct: 2116 MKQKDEDL----ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 2595 EVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDK 2654
EV + + TV Q + ++S + + D++ ++ + + E++ +
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSL----QDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 2655 MKKEV------------------------LQSSRDIMQSKSACEIKQSHQECSTQQTQQK 2690
+K++ L+ + I +SK+ E++ + C T Q + K
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 2691 KYLEQL-------HLPQSKPISPNFKVKTIK--LPTLDHTL---NETDHSYESHKQQSEI 2738
+ L QL H Q++ ++K++K L L ++L E + E +Q E
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 2739 DVQTFTKKQYLKTKKTEASTECSHKQSLAER-HYQLPKKEKRVTVQLPTESIQKNQEDKL 2797
D+Q K + T+ + L R H ++ KE+++ S+ +E+ +
Sbjct: 2348 DIQN------SKFSYEQLETDLQASRELTSRLHEEINMKEQKII------SLLSGKEEAI 2395
Query: 2798 KMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKV 2857
++ + R+ + +L + + +++ +E + ++ ++ ++ K +K++
Sbjct: 2396 QVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETL---KTIKKEN 2452
Query: 2858 ID--AHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKD 2915
I A LDS ++ Q ++++L + + S+ EK + IQE +N
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK---DQLIQEAAAENN--K 2507
Query: 2916 SKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKT 2975
K+EI +S + + + A E ++ RE+L Q+++ + + + L+
Sbjct: 2508 LKEEIRGLRSHMDDL------NSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQ 2561
Query: 2976 FQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMM 3035
+ L N L + K + + + ++EE + + E + VS + +
Sbjct: 2562 NKELENKY-AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTA 2620
Query: 3036 SSKTGKPGNKPTSL---DETSSKVSNVHVSNNKN-SEQKENKIAKEKTVQHQVA------ 3085
+ G G L +E ++S + S+ K +E +E + +K +V
Sbjct: 2621 LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL 2680
Query: 3086 ------AHHEATV-RSHVKTHQE 3101
HH+A + R+ +T +E
Sbjct: 2681 KKELKHLHHDAGIMRNETETAEE 2703
Score = 48.9 bits (115), Expect = 9e-05
Identities = 277/1562 (17%), Positives = 581/1562 (37%), Gaps = 245/1562 (15%)
Query: 1575 DEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDC-----TEREILISEEE 1629
DE+ + K + ++ S ++ ++E A L I ++ + D T+ E+ E +
Sbjct: 1395 DELQKLISKKEEDVSYLSGQLSEKE---AALTKIQTEIIEQEDLIKALHTQLEMQAKEHD 1451
Query: 1630 KGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKN-LFSEERSVKKGILIQED---EKG 1685
+ L + +E K +Q+ ++ L S + ++K+ +QE+ +G
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
Query: 1686 DINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQF 1745
I L + + +E K T+ L+ + ++D S N
Sbjct: 1512 TIERLTKSLADVESQVSAQNKE------KDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565
Query: 1746 FTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLL--LKKRQSLVERTV 1803
++C +L + TE E L + + + I E + L+K ++ ++
Sbjct: 1566 SSSC---ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY 1622
Query: 1804 SETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEI 1863
+ + V+ E Q +GK+ E K + L Q + + K +
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK-EKMRKF 1681
Query: 1864 IKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLE 1923
K L+ L+E + R + P GD K EC+E ++ +K+EL + +E
Sbjct: 1682 AKSKQQKILE-LEEENDRLRAEVHP---AGDTAK--ECMETLLSSNAS-MKEELERVKME 1734
Query: 1924 TSLRSLK-EAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLL----Q 1978
S K ++ S K+ E V +D K + G+ +Q ++ N+ ++ Q
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEV--QDLKHQIEGNVSKQ-ANLEATEKHDNQTNVTEEGTQ 1791
Query: 1979 PKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDA 2038
PG E D+LS + +C ++ ++ + + + Q D
Sbjct: 1792 SIPGETEEQ-------DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
Query: 2039 LEKSLRRLSNSHHK----SNVLESGDKTGVWTDTT--GEQHLRDEYMSRQLTSTVSVKNN 2092
L++ + L K S LE+ T + +T GE + E +++ ++
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEE 1904
Query: 2093 LTTKESDRAVRELKKDDV----FNSIQSAGKTVGKQ----QTYELRNDHQKMEGFHIKS- 2143
L+ + E +KDD+ N + ++G +++N+ + E ++K
Sbjct: 1905 LSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKC 1964
Query: 2144 -----PKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLK---QETKYS 2195
+K + +K T +S + + S + Q LLK QE K
Sbjct: 1965 VSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Query: 2196 NKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLM 2255
KD + + + + + + ++ + N +A +++ L S L+
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
Query: 2256 KTNTSTGLK-----MAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPL 2310
S + + +++ L + ++ +K+ + ++E L
Sbjct: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD-----------------EDLERRL 2127
Query: 2311 PPPPPLMMFPEKN--GFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPP 2368
+ +KN L +L EK+ E E+ + + D++ ++ ++
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLE-ETIGEIQVTLNKKDKEVQQLQENL------ 2180
Query: 2369 PPTPSQKPAHLLSSSAPEKHSG---DFMQQYSQK--EASNSQNSQAKIITGKTGVLPPPT 2423
T +Q A S S+ + D +++ +K +A S+ + ++ VL
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
Query: 2424 LPKPKLPKHIKDN-------KNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHT- 2475
+ +K N K + K + L C ++++ + + + H
Sbjct: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
Query: 2476 ETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKP 2535
+ QN ++K E K L D LS+++ +K + +I+ + + QN K
Sbjct: 2301 HSSQNELAKLESELKSLK-DQLTDLSNSLEKCKE-QKGNLEGIIRQ----QEADIQNSKF 2354
Query: 2536 YMRKFKTPLMIAEEKYRQQKEEIEKQKQE---------------------------SSYY 2568
+ +T L + E + EEI ++Q+
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414
Query: 2569 NIVKTQSQNQHITEVEKEMPLQKTNEEV-SLSGIDSE---------CTVVQPSPGSQSNA 2618
N++ + + + E E + + KTN+ + +L I E V S
Sbjct: 2415 NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD 2474
Query: 2619 RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEV--LQSSRDIMQSKSA---- 2672
RI+G D Q ++ ++ + A+ + +K+K+E+ L+S D + S++A
Sbjct: 2475 RIVG---DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 2673 --CEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYE 2730
+ ++ + T + Q+K L ++ L Q+K + K L+ L E++ + E
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN-------KYAKLEEKLKESEEANE 2584
Query: 2731 SHKQQSEIDVQTFTKKQYLKTKKTEASTEC-SHKQSLAERHYQLPKKEKRVTVQLPTESI 2789
++ L+ +K + S E S K S+++ Q+ ++ T+ L +
Sbjct: 2585 DLRRSFNA----------LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634
Query: 2790 QKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSA 2849
+ +E+ V R FS S + I EE L+ +K K
Sbjct: 2635 KVKEEE----VHRLSALFSSSQK--------------RIAELEEELVCVQKEAAKKVGEI 2676
Query: 2850 PKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQV 2909
+K+++ H D+ + + +TAE +++ + L E E+++
Sbjct: 2677 EDKLKKELKHLHHDA---GIMRNETETAE-----ERVAELARDLVE---------MEQKL 2719
Query: 2910 FSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPN 2969
TK++K Q +SF S+ Q + E RK + + L+++K+
Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE------ 2773
Query: 2970 KSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVK----------EEITHIKTQA 3019
Q LLN L+SE ++++ EN+L ++ E++ H+ +Q
Sbjct: 2774 -------QGLLNRERDALLSE--TAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Query: 3020 ED 3021
ED
Sbjct: 2825 ED 2826
Score = 46.6 bits (109), Expect = 4e-04
Identities = 142/816 (17%), Positives = 324/816 (39%), Gaps = 96/816 (11%)
Query: 2398 QKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKI 2457
+KE Q + +T + +L + L + +K K+D++ E
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE-------- 1221
Query: 2458 TTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAP 2517
SK+ + + + ++++ K +Q S S L P A + P
Sbjct: 1222 -QSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEE--PLFKATEQHHTQP 1278
Query: 2518 LIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQN 2577
+++S+ P+ ++ + I + Q +EIE +K E +K S
Sbjct: 1279 VLESNLCPDWPSHSEDASALQGGTSVAQI-----KAQLKEIEAEKVELE----LKVSSTT 1329
Query: 2578 QHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETV 2637
+T+ +E + + E+++ G++ E ++ S ++ +A L Q +S +
Sbjct: 1330 SELTKKSEE--VFQLQEQINKQGLEIE-SLKTVSHEAEVHAESL-----QQKLESSQLQI 1381
Query: 2638 AAKRLHHVLAASEDKDKMKKEVLQSSRDIMQ-SKSACEIKQSHQECSTQQTQQKKYLEQL 2696
A L H+ D+++K + + D+ S E + + + T+ +Q+ ++ L
Sbjct: 1382 AG--LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL 1439
Query: 2697 HLP---QSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQ-QSEIDVQTFTKKQYLKTK 2752
H Q+K K ++L + E + +Q Q ++ ++K+ LK
Sbjct: 1440 HTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN 1499
Query: 2753 KTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKN---------QEDKLKMVPRK 2803
K+ E S + ER L K V Q+ ++ +K+ QE++ K++
Sbjct: 1500 KS-LQEELSLARGTIER---LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 2804 QREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLD 2863
R S + L S E + ++ G E++ ++ E LK+ + + + + H +
Sbjct: 1556 DR--SLLENQSLSSSCESLK-LALEGLTEDKEKLVKEIESLKSSKIAESTEWQ--EKHKE 1610
Query: 2864 SQTQNFQQTQIQTAESKA-EHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQ 2922
Q + + +Q+ E+ + E +++ ++++EK E+ G + + +N K++++++ +
Sbjct: 1611 LQKE--YEILLQSYENVSNEAERIQHVVEAVRQEK-QELYG-KLRSTEANKKETEKQLQE 1666
Query: 2923 NKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSG---LKTFQTL 2979
+ +KE R K K++++ ++ + AE + +G + +TL
Sbjct: 1667 AEQEMEEMKEKMRKFAKS---------KQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 2980 LNTIPGWL--ISEDKREYAV----HIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTA 3033
L++ + K EY ++ + + + EE+ +K Q E + N+ T
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
Query: 3034 MMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKN-SEQKENKIAKEKTVQHQVAAHHEATV 3092
++T S+ + + ++ +S SE + + V ++H E +
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE--I 1835
Query: 3093 RSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVE 3152
++++ ++K + + K + S T EN LSQ KD ++
Sbjct: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQTL----------ENEKNTLLSQISTKDGELK 1885
Query: 3153 PPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDT 3188
+ E+ + N + ++ +LK+T
Sbjct: 1886 -------MLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Score = 42.7 bits (99), Expect = 0.006
Identities = 134/709 (18%), Positives = 262/709 (36%), Gaps = 97/709 (13%)
Query: 2429 LPKHIKDNKNDFSPKVELATSL-SDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLD 2487
L + D + FS + L SL S ++ K + + + + SS+ E Q + K L+
Sbjct: 815 LQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELE 874
Query: 2488 ERK--QLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPY-----MRKF 2540
K QL ++ + T+ T + +Q+ + S S E Q N + + ++
Sbjct: 875 ITKMDQLLLEKKRDVE-TLQQTIEEKDQQVTEI--SFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 2541 KTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSG 2600
K L + +KE++E+ + SS Q+ E+ + K +
Sbjct: 932 KEQLNLLSRAEEAKKEQVEEDNEVSS--------GLKQNYDEMSPAGQISKEELQHEFDL 983
Query: 2601 IDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVL 2660
+ E ++ R L N+ RL LA KD+ KKE+
Sbjct: 984 LKKE---------NEQRKRKLQAALINRKELLQ----RVSRLEEELANL--KDESKKEIP 1028
Query: 2661 QSSRDIMQSKSACEIKQSHQECSTQQTQQ-KKYLEQLHLPQS---KPISPNFKVKTIKLP 2716
S + + + E K+ ++C T + Q+ + YL+Q + + I + + K
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEE 1088
Query: 2717 TLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKK 2776
+ + + + + Q ++ ++ Q + K ++T+ S S+A
Sbjct: 1089 QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA-------LV 1141
Query: 2777 EKRVTVQLP----TESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKE 2832
++ V + P +E + E+K+ + +++ + +K ++ RK
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQL------------QKKLQEALTSRKA 1189
Query: 2833 ERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQ-------NFQQTQIQTAESKAEHKK 2885
+ K HL+ + + + D Q++ +Q QIQ ES K
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES--IDGK 1247
Query: 2886 LPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIV 2945
LP ++ Q+E C G++E + + Q + + S S +D
Sbjct: 1248 LP---STDQQESCSSTPGLEEPLFKATEQHHTQPVLE--SNLCPDWPSHSEDASA----- 1297
Query: 2946 EFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNL 3005
L+ + QI +++K+ EAE + LK T SE ++ ++ +
Sbjct: 1298 --LQGGTSVAQIKAQLKEIEAEKVELELKVSST---------TSELTKKSEEVFQLQEQI 1346
Query: 3006 EKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPG-----NKPTSLDETSSKVSNVH 3060
K EI +KT + + V E+ +Q + SS+ G LDE +S
Sbjct: 1347 NKQGLEIESLKTVSHEAEVHAES-LQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
Query: 3061 VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNI 3109
+ S Q K A +Q ++ + H + + K D I
Sbjct: 1406 EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI 1454
Score = 42.4 bits (98), Expect = 0.008
Identities = 137/706 (19%), Positives = 274/706 (38%), Gaps = 112/706 (15%)
Query: 2431 KHI-KDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDER 2489
+HI KD + + + + + M + +Q ++ SE+ Q +I+ + D
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133
Query: 2490 KQLSIDSAN---CLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMI 2546
S+ +S G+S K ++ I + + Q+ + + K L
Sbjct: 1134 DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
Query: 2547 AEEKYRQQKEEIEKQKQESSYYNIVKTQ-----SQNQHITEVEKEMPLQ----------K 2591
A+EK R +EE+++QK + YN ++ Q +N++I + +++ +Q
Sbjct: 1194 AQEKERHLREELKQQKDD---YNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
Query: 2592 TNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASED 2651
T+++ S S S + +P + V N + A L + ++
Sbjct: 1251 TDQQESCS---STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
Query: 2652 KDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVK 2711
K ++K +I K E+K S ST KK E L Q + +++
Sbjct: 1308 KAQLK--------EIEAEKVELELKVS----STTSELTKKSEEVFQL-QEQINKQGLEIE 1354
Query: 2712 TIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHK-QSLAERH 2770
++K T+ H S + + S++ + + L+ K E S K + ++
Sbjct: 1355 SLK--TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLS 1412
Query: 2771 YQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGR 2830
QL +KE +T ++ TE I+ QED +K + + M +
Sbjct: 1413 GQLSEKEAALT-KIQTEIIE--QEDLIKALHTQL---------------------EMQAK 1448
Query: 2831 KEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPY 2890
+ + I + + E + K P+ + +++ QQ Q + + K+ +
Sbjct: 1449 EHDERIKQLQVELCEMKQKPE---------EIGEESRAKQQIQRKLQAALISRKEALKEN 1499
Query: 2891 NSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRK 2950
SLQEE L +G E+ S Q QNK ++D G L +++
Sbjct: 1500 KSLQEELSL-ARGTIERLTKSLADVESQVSAQNK---------EKDTVLGRLALLQ---- 1545
Query: 2951 REELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLE---- 3006
EE ++++ + + E N+S + ++L + G ++EDK + I + +
Sbjct: 1546 -EERDKLITEMDRSLLE-NQSLSSSCESLKLALEG--LTEDKEKLVKEIESLKSSKIAES 1601
Query: 3007 -KVKEEITHIKTQAEDMLVSYENI---------IQTAMMSSKT---GKPGNKPTSLDETS 3053
+ +E+ ++ + E +L SYEN+ + A+ K GK + + ET
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 3054 SKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTH 3099
++ + ++K K AK K Q ++ E R + H
Sbjct: 1662 KQLQEAE-QEMEEMKEKMRKFAKSK--QQKILELEEENDRLRAEVH 1704
Score = 32.3 bits (72), Expect = 8.6
Identities = 40/247 (16%), Positives = 101/247 (40%), Gaps = 47/247 (19%)
Query: 1073 VEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIH------------ 1120
+++ E++ R+ V+ + + K L E +E K+S EE+H
Sbjct: 296 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA 355
Query: 1121 KGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGE 1180
+ ++++ E + +++ + + LQ QE +++AC + +N +Q +
Sbjct: 356 QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE------LQSACDALKDQNSKLLQDK 409
Query: 1181 EVKEIKPVEMDIQAGDVSSMRYKFENQSLDSI-----SSSSEEVLKKIKTLKTEDIQKGN 1235
+ ++ + Q D + K +Q L+ + ++S+ + T+ + + N
Sbjct: 410 NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN 469
Query: 1236 VLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYIS 1295
+ + + K V +++ KG + + L+E+K E++ +S
Sbjct: 470 IASLQ---------------------KRVVELEN---EKGALLLSSIELEELKAENEKLS 505
Query: 1296 TKKTITE 1302
++ T+ E
Sbjct: 506 SQITLLE 512
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 60.1 bits (144), Expect = 4e-08
Identities = 86/425 (20%), Positives = 162/425 (38%), Gaps = 35/425 (8%)
Query: 2285 SECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMM------FPEKNGFLPSLSTEKIKAEF 2338
++ PL P P PP + E P PP + M + P L + K++++
Sbjct: 895 TQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQ- 953
Query: 2339 ESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQ 2398
P PLPPPP S ++ PPPPPP P P H
Sbjct: 954 ---PPPPLPPPP--HPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHI 1008
Query: 2399 KEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKIT 2458
++ Q Q G PPP P+P P+ + + + SP+ + S +
Sbjct: 1009 QQPPPPQGQQPP--HPPPGQQPPP--PQPAKPQQVIQHHH--SPRHHKSDPYSTGHLREA 1062
Query: 2459 TSK---DQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQI 2515
S ++ S H Q + E + S+ P +K
Sbjct: 1063 PSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQ------PLVVVKEEKIH 1116
Query: 2516 APLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQS 2575
+P+I+S F S + PK + K P+ + ++ + ++ + N +
Sbjct: 1117 SPIIRSEPFSPSLRPEPPK-HPESIKAPVHL-PQRPEMKPVDVGRPVIRPPEQNAPPPGA 1174
Query: 2576 QNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPE 2635
++ + E + P+ +++ + + S ++VQ P + S+ S Q + E
Sbjct: 1175 PDKDKQKQEPKTPV-APKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAARE 1233
Query: 2636 TVAAKRLHHVLA--ASEDKDKMKKEVLQSSRD---IMQSKSACEIKQSHQECSTQQTQQK 2690
++ A A ++K+++++E ++S D + Q++ A E + QE QQ Q++
Sbjct: 1234 KEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQ 1293
Query: 2691 KYLEQ 2695
+ +Q
Sbjct: 1294 QQQQQ 1298
Score = 41.6 bits (96), Expect = 0.014
Identities = 43/172 (25%), Positives = 59/172 (34%), Gaps = 11/172 (6%)
Query: 2288 PLPPPSPPPPPPSNASSEIEFPLPPPP--PLMMFPEKNGFLPSLSTEKIKAEFESFPGLP 2345
P PPP PPPPP + P PPPP P P P ++ PG
Sbjct: 757 PPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSV 816
Query: 2346 LPP-----PPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQ-- 2398
P P+ + E PP TP H + S P H+ QQ S+
Sbjct: 817 FDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAV-VSPPALHNA-LPQQPSRPS 874
Query: 2399 KEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSL 2450
A+ A+ + P LP+P + + + D P TS+
Sbjct: 875 NRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSM 926
Score = 37.4 bits (85), Expect = 0.27
Identities = 112/522 (21%), Positives = 196/522 (37%), Gaps = 69/522 (13%)
Query: 2288 PLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPS-LSTEK-IKAEFESF---- 2341
PL P P PP P P P P P+ P P + T+K +K + ++
Sbjct: 246 PLQTPPPVPPQPQPP------PAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT 299
Query: 2342 -------PGLPLPPPPVDEKSERESSSMFLPPPPPPTP--SQKPAHLLSSSAPEK---HS 2389
P LP P P + +R SS + PP P Q PA SS E+ S
Sbjct: 300 IDPIHEPPSLP-PEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCS 358
Query: 2390 GDFMQQYSQKEASNSQNSQAKIITGKTG------VLPPP---TLPKPKLPKHIKDNKNDF 2440
G + +++K A+ + + G ++ P + K KL + +F
Sbjct: 359 GILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEF 418
Query: 2441 SPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCL 2500
V L S C D + +V + + + + +K DE ++ + +
Sbjct: 419 GADVRLMFS----NCYKYNPPDHE--VVAMARKLQDVFEMRFAKMPDEPEEPVVAVS--- 469
Query: 2501 SHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEK 2560
S VP P K +AP S S +SS + + + +AE ++Q + + +
Sbjct: 470 SPAVP----PPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAE--LQEQLKAVHE 523
Query: 2561 QKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARI 2620
Q S K + + + E +KE K EEV S+ P ++N+
Sbjct: 524 QLAALSQPQQNKPKKKEKDKKEKKKEK--HKRKEEVE-ENKKSKAKEPPPKKTKKNNS-- 578
Query: 2621 LGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQ 2680
S++ +S P + +K SE++DK K + R + + ++ +
Sbjct: 579 ----SNSNVSKKEPAPMKSK--PPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGR 632
Query: 2681 ECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTL-DHTLNETDHSYESHKQQSE-I 2738
Q+++ L S P +T+K TL + T + K Q+E +
Sbjct: 633 VVHIIQSREPS------LKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKV 686
Query: 2739 DV-QTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKR 2779
DV +K + + ++E+S+E S S PK +K+
Sbjct: 687 DVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKK 728
Score = 35.0 bits (79), Expect = 1.3
Identities = 40/159 (25%), Positives = 63/159 (39%), Gaps = 22/159 (13%)
Query: 2662 SSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLH-LPQSKPISPNFKVKTIKLPTLDH 2720
SS D S E +++ Q + Q Q K EQL L Q + P K K K
Sbjct: 492 SSSDSDSSTDDSEEERA-QRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK------ 544
Query: 2721 TLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRV 2780
+ E HK++ E++ +K + KKT+ + + S KKE
Sbjct: 545 -----EKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVS---------KKEPAP 590
Query: 2781 TVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSE 2819
P + + +EDK K + +++ D KLPG +
Sbjct: 591 MKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEK 629
Score = 32.3 bits (72), Expect = 8.6
Identities = 31/136 (22%), Positives = 58/136 (42%), Gaps = 27/136 (19%)
Query: 3046 PTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLD 3105
P+S D +S S+ S + + E++ ++A+ +Q Q+ A HE Q L
Sbjct: 483 PSSSDSSSDSSSDSDSSTDDSEEERAQRLAE---LQEQLKAVHE----------QLAALS 529
Query: 3106 DSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEI 3165
P K + + ++ E + E + KK EPPP++ ++K+
Sbjct: 530 QPQQNKPKKKEK---------DKKEKKKEKHKRKEEVEENKKSKAKEPPPKK--TKKNNS 578
Query: 3166 HRANTS---PSPPRSR 3178
+N S P+P +S+
Sbjct: 579 SNSNVSKKEPAPMKSK 594
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 59.7 bits (143), Expect = 5e-08
Identities = 89/383 (23%), Positives = 164/383 (42%), Gaps = 55/383 (14%)
Query: 2650 EDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKP------ 2703
E DK+ + + ++ R + QS E + + + +T+ TQ + LH Q K
Sbjct: 590 EQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV----LHAEQEKAKVTEEL 645
Query: 2704 ISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQT--FTKKQYLKTKKTEASTEC- 2760
+ +V ++L H ET+ + + E D+ TK Q ++ E S +
Sbjct: 646 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQ 705
Query: 2761 ----SHKQSLAERHYQLPKKEKRVT-VQLPTESIQKN-QEDKLKMVPRKQREFSGSDRGK 2814
S KQ+ + ++ E+ +T +++ ES++KN E K K + + D +
Sbjct: 706 SKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
Query: 2815 LPGSEEKNQGPSMIGRKEERLITERKH-EHLKNKSAPKVVKQKVIDAHL--DSQTQNFQQ 2871
EE ++ ++ K+ R+ T++ E L A + + HL ++ ++ QQ
Sbjct: 766 KSYQEELDKLRQLL--KKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQ 823
Query: 2872 TQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQ---EITQNKSFFS 2928
Q A+ A +KL Q +EKCL ++ Q+ + TK ++Q E+ +NKS S
Sbjct: 824 YQEVCAQRDAYQQKLVQ-----LQEKCLALQA----QITALTKQNEQHIKELEKNKSQMS 874
Query: 2929 SVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLI 2988
V+ + D + I+ Q S ++FE E + +G T++NTI
Sbjct: 875 GVEAAASDPSEKVKKIMN--------QVFQSLRREFELEESYNGRTILGTIMNTIK---- 922
Query: 2989 SEDKREYAVHIAMENNLEKVKEE 3011
V + + N E+ KEE
Sbjct: 923 -------MVTLQLLNQQEQEKEE 938
Score = 40.8 bits (94), Expect = 0.024
Identities = 99/534 (18%), Positives = 206/534 (38%), Gaps = 84/534 (15%)
Query: 2367 PPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPK 2426
P P P +P H + SGD M + EA N++ ++ K + K
Sbjct: 486 PLYPAPLSQPPHF-------QGSGD-MASFLMTEA-RQHNTEIRMAVSKVADKMDHLMTK 536
Query: 2427 -PKLPKHIKDNKN---DFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
+L KH N S +E + +S+++ +I ++ K ++ S E + + I
Sbjct: 537 VEELQKHSAGNSMLIPSMSVTMETSMIMSNIQ-RIIQENERLKQEILEKSNRIEEQNDKI 595
Query: 2483 SKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKT 2542
S+ L ER Q ++ +N + +++S ++ +
Sbjct: 596 SE-LIERNQRYVEQSNLMMEK----------------RNNSLQTATENTQAR-------- 630
Query: 2543 PLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGID 2602
++ AE++ + EE+ + S+ + T Q + E E +M L ++ +E L +
Sbjct: 631 -VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKK---ETELQMQLTESLKETDL--LR 684
Query: 2603 SECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKD---KMKKEV 2659
+ T VQ L S+ S E K+L + + E++ +++KE
Sbjct: 685 GQLTKVQAKLSE------LQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKES 738
Query: 2660 LQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLD 2719
L+ + + KSA E Q+ +E + ++ L++L L
Sbjct: 739 LEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLR------------------QLLK 780
Query: 2720 HTLNETDHSYESHKQ--QSEIDVQTFTKKQYLKTKKTEASTE-----CSHKQSLAERHYQ 2772
T TD + Q+E+ Q K ++L + + C+ + + ++ Q
Sbjct: 781 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ 840
Query: 2773 LPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMI--GR 2830
L +EK + +Q ++ K E +K + + + + SG + SE+ + + +
Sbjct: 841 L--QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSL 898
Query: 2831 KEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHK 2884
+ E + E + + +K + L+ Q Q +++ + E KAE +
Sbjct: 899 RREFELEESYNGRTILGTIMNTIKMVTLQL-LNQQEQEKEESSSEEEEEKAEER 951
Score = 33.5 bits (75), Expect = 3.8
Identities = 31/127 (24%), Positives = 56/127 (44%), Gaps = 3/127 (2%)
Query: 275 QYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLE-KHTEE 333
Q + N ++ +S Q T + + EQE +KV + T VSHL+ K T
Sbjct: 603 QRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAH 662
Query: 334 VNQASQFHQYVQETVIDTP-EDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIK 392
+ ++ + E++ +T ++ KV KL + Q E S Q + + ++ ++K
Sbjct: 663 QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRKQLELK 721
Query: 393 TESEYEE 399
S EE
Sbjct: 722 VTSLEEE 728
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sapiens]
Length = 505
Score = 58.9 bits (141), Expect = 9e-08
Identities = 39/95 (41%), Positives = 42/95 (44%), Gaps = 25/95 (26%)
Query: 2288 PLPPPS------PPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESF 2341
P PPPS PPPPPPS S + PPPPP M+P LPS S
Sbjct: 310 PPPPPSRAPTAAPPPPPPSRPSVAV----PPPPPNRMYPPPPPALPS-----------SA 354
Query: 2342 PGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKP 2376
P P PPPP S + PPPPPP P P
Sbjct: 355 PSGPPPPPP----SVLGVGPVAPPPPPPPPPPPGP 385
Score = 50.4 bits (119), Expect = 3e-05
Identities = 46/157 (29%), Positives = 55/157 (35%), Gaps = 47/157 (29%)
Query: 2279 ENNVKESECPLPPPS-----PPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEK 2333
+N ++ P PPPS PPPPPP N+ PPPPP G P +
Sbjct: 269 KNELRRQAPPPPPPSRGGPPPPPPPPHNSG-------PPPPPA----RGRGAPPPPPSRA 317
Query: 2334 IKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFM 2393
A P PPPP S+ +PPPPP P L SSAP
Sbjct: 318 PTAA-------PPPPPP-------SRPSVAVPPPPPNRMYPPPPPALPSSAP-------- 355
Query: 2394 QQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLP 2430
+ + G V PPP P P P
Sbjct: 356 ---------SGPPPPPPSVLGVGPVAPPPPPPPPPPP 383
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1733 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1783
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1784 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1831
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1832 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1890
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1891 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1941
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1762 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1812
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1813 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1834
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1710 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1760
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1761 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1808
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1809 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1867
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1868 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1918
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1739 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1789
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1790 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1811
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1713 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1763
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1764 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1811
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1812 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1870
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1871 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1921
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1742 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1792
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1793 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1814
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1693 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1743
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1744 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1791
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1792 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1850
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1851 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1901
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1722 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1772
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1773 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1794
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1730 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1780
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1781 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1828
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1829 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1887
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1888 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1938
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1759 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1809
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1810 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1831
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1664 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1714
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1715 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1762
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1763 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1821
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1822 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1872
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1693 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1743
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1744 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1765
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1735 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1785
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1786 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1833
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1834 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1892
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1893 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1943
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1764 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1814
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1815 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1836
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 58.9 bits (141), Expect = 9e-08
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 51/234 (21%)
Query: 2275 NFNPENNVKESECPLPPP---SPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLST 2331
NF N+ S CPLPPP SPP PPP+ A PL PPP + F + F P S
Sbjct: 1740 NFAHPPNISPSACPLPPPPPISPPSPPPAPA------PLAPPPDISPF---SLFCPPPSP 1790
Query: 2332 EKIKAEFESFPGLPLPPP---PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
I LPLPPP P+ + + LPP P P P P S P
Sbjct: 1791 PSIP--------LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPP----SIPCPPPP 1838
Query: 2389 SGDFMQ-----------QYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKD-- 2435
S F+ + A ++S ++ T P PK L +H+K+
Sbjct: 1839 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGIL-RHVKNLA 1897
Query: 2436 -------NKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVI 2482
N K L T++S+++ T + M +TS ++ + N++
Sbjct: 1898 ELEKSVANMYSQIEKNYLRTNVSELQ---TMCPSEVTNMEITSEQNKGSLNNIV 1948
Score = 38.1 bits (87), Expect = 0.16
Identities = 31/106 (29%), Positives = 37/106 (34%), Gaps = 38/106 (35%)
Query: 2273 PINFNPENNVKESECPLPPPSPPP-----PPPSNASSEIEFPLPPPPPLMMFPEKNGFLP 2327
P P ++ PPPSPP PPP+ + PP PPL LP
Sbjct: 1769 PAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL---------LP 1819
Query: 2328 SLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS 2373
T PLPPPP +P PPPP+ S
Sbjct: 1820 PFPT-------------PLPPPPPS-----------IPCPPPPSAS 1841
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 57.8 bits (138), Expect = 2e-07
Identities = 132/675 (19%), Positives = 274/675 (40%), Gaps = 85/675 (12%)
Query: 2391 DFMQQYSQKEASNSQ-----NSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVE 2445
D Q+Y++K+ + +S +K ++ V PP KH K+ S VE
Sbjct: 757 DVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPE-------KHEKEIIALKSNIVE 809
Query: 2446 LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDER--KQLSIDSANCLSHT 2503
L LS+++ K +DQ+K+ +TS E+T K+ + ++ + + +++ + + L+ T
Sbjct: 810 LKKQLSELKKKC--GEDQEKIHALTS-ENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 866
Query: 2504 VPGTSAPRKK-----QIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEI 2558
+KK Q IK + +N + ++ L E K + +
Sbjct: 867 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 926
Query: 2559 EKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNA 2618
K Q+S+ + + + I + E+ QK + I + + +
Sbjct: 927 RKV-QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 985
Query: 2619 RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQS 2678
+ +QLS + + ++ V ++ DK+KKE+ +D+ E
Sbjct: 986 KATEKELKDQLSEQTQKYSVSEE--EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1043
Query: 2679 HQECSTQQTQQKKYLEQLHLPQSKPISPNF-KVKTIKLPTLDHTLNETDHSYESHKQQSE 2737
+ +++T + Q K +S + +VK +K ++ E+ KQ SE
Sbjct: 1044 MERALSRKTDELN-------KQLKDLSQKYTEVKNVKEKLVE----------ENAKQTSE 1086
Query: 2738 I-DVQTFTKKQYLKTKKTEA------STECSHKQSLAERHYQLPKKEKRVTVQLPTESIQ 2790
I VQ +KQ++ ++ EA T + K+ L K+++ VT Q
Sbjct: 1087 ILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1146
Query: 2791 KNQE----DKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKN 2846
KN + L++ ++E G + L EE++Q K E + +
Sbjct: 1147 KNSSVPLAEHLQIKEAFEKEV-GIIKASLREKEEESQ------NKMEEVSKLQSEVQNTK 1199
Query: 2847 KSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQE 2906
++ K+ ++V+D T++ +TQI + K + N EE C EV ++
Sbjct: 1200 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN------LNRKYEEVCEEVLHAKK 1253
Query: 2907 KQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEA 2966
K++ + KD K+ + + S +K+ + K I E R+ +E KQ EA
Sbjct: 1254 KEI--SAKDEKELL--HFSIEQEIKDQKERCDKSLTTITELQRRIQE------SAKQIEA 1303
Query: 2967 EPNK-----SGLKTFQTLLNTIPGWLISE---DKREYAVHIAMENNLEKVKEEITHIKTQ 3018
+ NK + ++ + LN + + KR+ + +++ ++ +++++ Q
Sbjct: 1304 KDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1363
Query: 3019 AEDMLVSYENIIQTA 3033
++++ Y + +A
Sbjct: 1364 HQEVIAIYRTHLLSA 1378
Score = 42.7 bits (99), Expect = 0.006
Identities = 149/748 (19%), Positives = 290/748 (38%), Gaps = 113/748 (15%)
Query: 2426 KPKLPKHIKDNKNDFSPKVELATSLSDMECKIT--TSKDQKKVMVMTSSEHTETKQNVIS 2483
K KL +H+K +++ K L ++ KIT T K+Q T Q I
Sbjct: 662 KAKLAQHVKPEEHE-QVKSRLEQKSGELGKKITELTLKNQ-------------TLQKEIE 707
Query: 2484 KSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTP 2543
K + K L + N + K PL S +S +
Sbjct: 708 KVYLDNKLLKEQAHNL--------TIEMKNHYVPLKVSEDMKKSHDA-----IIDDLNRK 754
Query: 2544 LMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHI----TEVEKEMPLQKTNE---EV 2596
L+ +KY ++K E+EK E+ ++ K S+ + + + EKE+ K+N +
Sbjct: 755 LLDVTQKYTEKKLEMEKLLLEND--SLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 812
Query: 2597 SLSGIDSECTVVQPSPGS--QSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDK 2654
LS + +C Q + N + + S+ + + E V + + +
Sbjct: 813 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 872
Query: 2655 MKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNF-KVKTI 2713
+KK+ +++ ++ K EI + + E + Q + + H + +S + KV+
Sbjct: 873 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 932
Query: 2714 KLPTLDHTLNETDHSYESHK----QQSEID-VQTFTKKQYLKTKKTEASTECSHKQSLAE 2768
L + + H Q+ E+D +Q K +Y E EC K E
Sbjct: 933 NAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE---ECERKFKATE 989
Query: 2769 RHYQLPKKEKRVTVQLPTESIQKNQE--DKLKM-VPRKQREFSGSDRGKLPGSEEKNQGP 2825
+ + E+ + E ++KN++ DKLK + Q++ R K E+ ++
Sbjct: 990 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL----RDKTVLIEKSHEME 1045
Query: 2826 SMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQT-----QNFQQTQ-IQTAES 2879
+ RK + L + K K K VK+K+++ + + QN Q Q + +
Sbjct: 1046 RALSRKTDELNKQLKDLSQKYTEV-KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1104
Query: 2880 KAEHKKLPQPYNSLQEE-----KC----------------------------LEVKGIQE 2906
+A K L +L+EE +C L++K E
Sbjct: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1164
Query: 2907 KQV--FSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVE---------FLRKREELQ 2955
K+V + K+E +QNK S +S+ + K AL +E + + +L+
Sbjct: 1165 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
Query: 2956 QILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEI-TH 3014
+S + + A N+ + + +L+ + ++D++E +H ++E ++ KE
Sbjct: 1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE-LLHFSIEQEIKDQKERCDKS 1283
Query: 3015 IKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKI 3074
+ T E E+ Q +K + N L + + +S + ++ ++++ I
Sbjct: 1284 LTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLI 1343
Query: 3075 AKEKTVQHQVAAHHEATVRSHVKTHQEI 3102
T+QHQV + E + + HQE+
Sbjct: 1344 ---DTLQHQVKS-LEQQLADADRQHQEV 1367
Score = 38.5 bits (88), Expect = 0.12
Identities = 177/976 (18%), Positives = 362/976 (37%), Gaps = 173/976 (17%)
Query: 2651 DKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQK--KYLEQLHLPQSKPISPNF 2708
+++ M + L+S R+ ++S A + KQ + T + + KY E HL S
Sbjct: 319 NEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRK 378
Query: 2709 KVKTIKLPTLDHTLNE-TDHSYESHKQQSEI---------DVQTFTKKQYLKTKKTEAST 2758
+ +K + ++ T +H Q + ++++ + LK + T
Sbjct: 379 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRT 438
Query: 2759 EC-SHKQSLAERHYQLPKKEKRV-TVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLP 2816
C S KQ + +L K + L E ++++ ++++K + ++ + ++
Sbjct: 439 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV----QKRMY 494
Query: 2817 GSEEK-NQGPSMIGRKEERLITE------RKHEHLKNKSAPKVVKQKVIDAHLDSQTQNF 2869
SE K Q + +E L +E R E LK++ VK + A +
Sbjct: 495 ESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQI 554
Query: 2870 QQTQIQTAESKAEHKKLPQPYNSLQEEKCL-----EVKGIQEKQVFSNTKD--SKQEITQ 2922
+Q ++ E K + KL + LQ+E + E KG + ++ K+ +K ++
Sbjct: 555 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSI 614
Query: 2923 NKSFFSSVKESQRDD-GKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLN 2981
F ++K S ++ + A +VE R+ E+ LS ++Q + E
Sbjct: 615 PAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS---LSEIRQLKRE-------------- 657
Query: 2982 TIPGWLISEDKREYAVHIAMENNLEKVKEEIT-HIKTQAEDMLVSYENIIQTAMMSSKTG 3040
LE VK ++ H+K + + + S + K+G
Sbjct: 658 -----------------------LENVKAKLAQHVKPEEHEQVKS--------RLEQKSG 686
Query: 3041 KPGNKPTSL---DETSSK-VSNVHVSNNKNSEQKENKIAKEKT------VQHQVAAHHEA 3090
+ G K T L ++T K + V++ N EQ N + K V + H+A
Sbjct: 687 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDA 746
Query: 3091 TVR---------SHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTE------- 3134
+ + T ++++++ + SL + + E
Sbjct: 747 IIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSN 806
Query: 3135 -NPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSP-SPPRSRSEQLVRLKDTTAKL 3192
K +LS+ KK + S+ + + + ++ P ++ E + L DT AK
Sbjct: 807 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 866
Query: 3193 SKGAIPCPAATP------VPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINH 3246
++ + V I +K + + + QIK E ++
Sbjct: 867 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY------ISLAEHEAKMS 920
Query: 3247 AASGSFRESVDAQEEI----RKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVP 3302
+ S S R+ D+ EI RK ++ +H + + + D ++ KV
Sbjct: 921 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE-------IKAQKKELDTIQECIKVKYA 973
Query: 3303 PRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNH 3362
P +S +E R + E + D +E + + E E K N+ + N
Sbjct: 974 PIVS-----FEECERKFKATEKELKDQLSEQTQKYSVSE----EEVKKNK------QEND 1018
Query: 3363 NIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGM 3422
+++E T K+ T L S E+ + K + + + LS+ ++ +
Sbjct: 1019 KLKKEIFTLQKDLRDKTVLIEKS---------HEMERALSRKTDELNKQLKDLSQKYTEV 1069
Query: 3423 DAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQK 3482
+ ++VE K +S A ++ +H P + + + ++ KE K+ Q+
Sbjct: 1070 KNVKEKLVEENAKQTS--EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1127
Query: 3483 TWQESGRVFKGLGYATAD--------ASATEMRTTFQEE----SAFISEAAAPRQGNMYT 3530
+++ + L + A +++ F++E A + E Q M
Sbjct: 1128 CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1187
Query: 3531 LSKDSLSNGVPSGRQA 3546
+SK L + V + +QA
Sbjct: 1188 VSK--LQSEVQNTKQA 1201
Score = 38.5 bits (88), Expect = 0.12
Identities = 148/787 (18%), Positives = 313/787 (39%), Gaps = 135/787 (17%)
Query: 1181 EVKEIKPVEMDIQAGDVSSM------RYKFENQSLDSISSSSEEVLKKIKTL-KTEDIQK 1233
E K K EM+ QA ++S+ KFEN SS S EV +K K L + E +
Sbjct: 590 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMK----SSLSNEVNEKAKKLVEMEREHE 645
Query: 1234 GNVLNCRWLFENQPIDKIKESQ----EGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKE 1289
++ R L K K +Q E E VK+ + + G++ K T +++
Sbjct: 646 KSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITEL-TLKNQTLQK 704
Query: 1290 ESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRG 1349
E + + + +E Q + M PL +D + S+ + +++ +
Sbjct: 705 EIEKVYLDNKLLKE--QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 762
Query: 1350 TRWLFETKPL----DSINKS----ETVYVIKSVTQEDI---------QKGDVSSVRYRF- 1391
T E + L DS++K ETV+V +++I K +S ++ +
Sbjct: 763 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 822
Query: 1392 -ETQPLDQISEESHNIMPSIDH--------------IQGGNVKTSRQFFE-SENFDKNN- 1434
+ + + ++ E+ N+ + + + KT+R+ + + F+ N
Sbjct: 823 EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 882
Query: 1435 -YIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWL 1493
+++ NEI K N++ +T ++++ E + ++ + + + + Q++
Sbjct: 883 EFVKIKDKNEILKRNLE--------NTQNQIKAEYI------SLAEHEAKMSSLSQSMRK 928
Query: 1494 FENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIK 1553
++ + + KG +EEI LH E + +K E+
Sbjct: 929 VQDSNAEILANYRKG-----QEEI--------------VTLHA--EIKAQKKEL------ 961
Query: 1554 ETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLL 1613
+T+++ KV AP + E E + + +L +Q S + QK + +++
Sbjct: 962 DTIQECI--KVKYAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNK---- 1014
Query: 1614 SKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSV 1673
+ D ++EI +++ + KT L+ +S E ++ + +K+L + V
Sbjct: 1015 QENDKLKKEIFTLQKDLRD----KTVLIEKSHEMERALSRKTD-ELNKQLKDLSQKYTEV 1069
Query: 1674 K--KGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISE 1731
K K L++E+ K + L + +E+ E + + TI NL
Sbjct: 1070 KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENL----------- 1118
Query: 1732 RAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLL 1791
+ ++ + +R + T + L L + N ++ + KE +V K
Sbjct: 1119 KEELKSMQRCYEKEQQTVTKLHQL-----LENQKNSSVPLAEHLQIKEAFEKEVGIIKAS 1173
Query: 1792 LKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQA 1851
L++++ + + E + +V NT + + K + K DL + ++SL++
Sbjct: 1174 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEK 1233
Query: 1852 ---VNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNT 1908
+N+K EE++ KE S + ++ +I +I+ E +K+ T
Sbjct: 1234 LANLNRKYEEVCEEVLHAKK-------KEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1286
Query: 1909 KTEILKK 1915
TE+ ++
Sbjct: 1287 ITELQRR 1293
Score = 35.0 bits (79), Expect = 1.3
Identities = 34/195 (17%), Positives = 86/195 (44%), Gaps = 5/195 (2%)
Query: 242 MMEESEMCAVP-GGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
++E + +VP ++K+ FE E+ + + + + + QN+ E+ + S+V ++ +
Sbjct: 1142 LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1201
Query: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
+ +E + K +++ + + E++ ++ ++ V E V+ + E K
Sbjct: 1202 LKKLET-REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1260
Query: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQR 420
+LL E+ +++ DK +TT + + +E+ K T ++ +R
Sbjct: 1261 EKELLHFSIEQEIKDQKERCDKSLTTIT---ELQRRIQESAKQIEAKDNKITELLNDVER 1317
Query: 421 KETSTTRYSDHSVTS 435
+ + S + TS
Sbjct: 1318 LKQALNGLSQLTYTS 1332
Score = 32.7 bits (73), Expect = 6.6
Identities = 47/230 (20%), Positives = 89/230 (38%), Gaps = 42/230 (18%)
Query: 1769 LTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTF 1828
L K E E+ + E K L Q E + ++ + T ++ +
Sbjct: 1037 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1096
Query: 1829 GKIPKEEI--IKGDLTSTLNSLSQAVN---------QKTVTKTEEIIK------------ 1865
+P E++ +K L T+ +L + + Q+TVTK ++++
Sbjct: 1097 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1156
Query: 1866 -----------GNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKA-TNTKTEIL 1913
G + A+L+ +E S E + + +++ + L+K T ++
Sbjct: 1157 LQIKEAFEKEVGIIKASLREKEEESQNKME--EVSKLQSEVQNTKQALKKLETREVVDLS 1214
Query: 1914 KKELLKDDLETSLRSLKE----AQRSFKEVHKEGVIKKDAKAVMAGSSGE 1959
K + K DLET + SL E R ++EV +E V+ K + A E
Sbjct: 1215 KYKATKSDLETQISSLNEKLANLNRKYEEVCEE-VLHAKKKEISAKDEKE 1263
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 57.8 bits (138), Expect = 2e-07
Identities = 132/675 (19%), Positives = 274/675 (40%), Gaps = 85/675 (12%)
Query: 2391 DFMQQYSQKEASNSQ-----NSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVE 2445
D Q+Y++K+ + +S +K ++ V PP KH K+ S VE
Sbjct: 770 DVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPE-------KHEKEIIALKSNIVE 822
Query: 2446 LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDER--KQLSIDSANCLSHT 2503
L LS+++ K +DQ+K+ +TS E+T K+ + ++ + + +++ + + L+ T
Sbjct: 823 LKKQLSELKKKC--GEDQEKIHALTS-ENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 879
Query: 2504 VPGTSAPRKK-----QIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEI 2558
+KK Q IK + +N + ++ L E K + +
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 939
Query: 2559 EKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNA 2618
K Q+S+ + + + I + E+ QK + I + + +
Sbjct: 940 RKV-QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 998
Query: 2619 RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQS 2678
+ +QLS + + ++ V ++ DK+KKE+ +D+ E
Sbjct: 999 KATEKELKDQLSEQTQKYSVSEE--EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1056
Query: 2679 HQECSTQQTQQKKYLEQLHLPQSKPISPNF-KVKTIKLPTLDHTLNETDHSYESHKQQSE 2737
+ +++T + Q K +S + +VK +K ++ E+ KQ SE
Sbjct: 1057 MERALSRKTDELN-------KQLKDLSQKYTEVKNVKEKLVE----------ENAKQTSE 1099
Query: 2738 I-DVQTFTKKQYLKTKKTEA------STECSHKQSLAERHYQLPKKEKRVTVQLPTESIQ 2790
I VQ +KQ++ ++ EA T + K+ L K+++ VT Q
Sbjct: 1100 ILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
Query: 2791 KNQE----DKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKN 2846
KN + L++ ++E G + L EE++Q K E + +
Sbjct: 1160 KNSSVPLAEHLQIKEAFEKEV-GIIKASLREKEEESQ------NKMEEVSKLQSEVQNTK 1212
Query: 2847 KSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQE 2906
++ K+ ++V+D T++ +TQI + K + N EE C EV ++
Sbjct: 1213 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN------LNRKYEEVCEEVLHAKK 1266
Query: 2907 KQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEA 2966
K++ + KD K+ + + S +K+ + K I E R+ +E KQ EA
Sbjct: 1267 KEI--SAKDEKELL--HFSIEQEIKDQKERCDKSLTTITELQRRIQE------SAKQIEA 1316
Query: 2967 EPNK-----SGLKTFQTLLNTIPGWLISE---DKREYAVHIAMENNLEKVKEEITHIKTQ 3018
+ NK + ++ + LN + + KR+ + +++ ++ +++++ Q
Sbjct: 1317 KDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
Query: 3019 AEDMLVSYENIIQTA 3033
++++ Y + +A
Sbjct: 1377 HQEVIAIYRTHLLSA 1391
Score = 42.7 bits (99), Expect = 0.006
Identities = 149/748 (19%), Positives = 290/748 (38%), Gaps = 113/748 (15%)
Query: 2426 KPKLPKHIKDNKNDFSPKVELATSLSDMECKIT--TSKDQKKVMVMTSSEHTETKQNVIS 2483
K KL +H+K +++ K L ++ KIT T K+Q T Q I
Sbjct: 675 KAKLAQHVKPEEHE-QVKSRLEQKSGELGKKITELTLKNQ-------------TLQKEIE 720
Query: 2484 KSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTP 2543
K + K L + N + K PL S +S +
Sbjct: 721 KVYLDNKLLKEQAHNL--------TIEMKNHYVPLKVSEDMKKSHDA-----IIDDLNRK 767
Query: 2544 LMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHI----TEVEKEMPLQKTNE---EV 2596
L+ +KY ++K E+EK E+ ++ K S+ + + + EKE+ K+N +
Sbjct: 768 LLDVTQKYTEKKLEMEKLLLEND--SLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 825
Query: 2597 SLSGIDSECTVVQPSPGS--QSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDK 2654
LS + +C Q + N + + S+ + + E V + + +
Sbjct: 826 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 885
Query: 2655 MKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNF-KVKTI 2713
+KK+ +++ ++ K EI + + E + Q + + H + +S + KV+
Sbjct: 886 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 945
Query: 2714 KLPTLDHTLNETDHSYESHK----QQSEID-VQTFTKKQYLKTKKTEASTECSHKQSLAE 2768
L + + H Q+ E+D +Q K +Y E EC K E
Sbjct: 946 NAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE---ECERKFKATE 1002
Query: 2769 RHYQLPKKEKRVTVQLPTESIQKNQE--DKLKM-VPRKQREFSGSDRGKLPGSEEKNQGP 2825
+ + E+ + E ++KN++ DKLK + Q++ R K E+ ++
Sbjct: 1003 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL----RDKTVLIEKSHEME 1058
Query: 2826 SMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQT-----QNFQQTQ-IQTAES 2879
+ RK + L + K K K VK+K+++ + + QN Q Q + +
Sbjct: 1059 RALSRKTDELNKQLKDLSQKYTEV-KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1117
Query: 2880 KAEHKKLPQPYNSLQEE-----KC----------------------------LEVKGIQE 2906
+A K L +L+EE +C L++K E
Sbjct: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1177
Query: 2907 KQV--FSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVE---------FLRKREELQ 2955
K+V + K+E +QNK S +S+ + K AL +E + + +L+
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 2956 QILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEI-TH 3014
+S + + A N+ + + +L+ + ++D++E +H ++E ++ KE
Sbjct: 1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE-LLHFSIEQEIKDQKERCDKS 1296
Query: 3015 IKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKI 3074
+ T E E+ Q +K + N L + + +S + ++ ++++ I
Sbjct: 1297 LTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLI 1356
Query: 3075 AKEKTVQHQVAAHHEATVRSHVKTHQEI 3102
T+QHQV + E + + HQE+
Sbjct: 1357 ---DTLQHQVKS-LEQQLADADRQHQEV 1380
Score = 38.5 bits (88), Expect = 0.12
Identities = 177/976 (18%), Positives = 362/976 (37%), Gaps = 173/976 (17%)
Query: 2651 DKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQK--KYLEQLHLPQSKPISPNF 2708
+++ M + L+S R+ ++S A + KQ + T + + KY E HL S
Sbjct: 332 NEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRK 391
Query: 2709 KVKTIKLPTLDHTLNE-TDHSYESHKQQSEI---------DVQTFTKKQYLKTKKTEAST 2758
+ +K + ++ T +H Q + ++++ + LK + T
Sbjct: 392 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRT 451
Query: 2759 EC-SHKQSLAERHYQLPKKEKRV-TVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLP 2816
C S KQ + +L K + L E ++++ ++++K + ++ + ++
Sbjct: 452 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV----QKRMY 507
Query: 2817 GSEEK-NQGPSMIGRKEERLITE------RKHEHLKNKSAPKVVKQKVIDAHLDSQTQNF 2869
SE K Q + +E L +E R E LK++ VK + A +
Sbjct: 508 ESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQI 567
Query: 2870 QQTQIQTAESKAEHKKLPQPYNSLQEEKCL-----EVKGIQEKQVFSNTKD--SKQEITQ 2922
+Q ++ E K + KL + LQ+E + E KG + ++ K+ +K ++
Sbjct: 568 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSI 627
Query: 2923 NKSFFSSVKESQRDD-GKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLN 2981
F ++K S ++ + A +VE R+ E+ LS ++Q + E
Sbjct: 628 PAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS---LSEIRQLKRE-------------- 670
Query: 2982 TIPGWLISEDKREYAVHIAMENNLEKVKEEIT-HIKTQAEDMLVSYENIIQTAMMSSKTG 3040
LE VK ++ H+K + + + S + K+G
Sbjct: 671 -----------------------LENVKAKLAQHVKPEEHEQVKS--------RLEQKSG 699
Query: 3041 KPGNKPTSL---DETSSK-VSNVHVSNNKNSEQKENKIAKEKT------VQHQVAAHHEA 3090
+ G K T L ++T K + V++ N EQ N + K V + H+A
Sbjct: 700 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDA 759
Query: 3091 TVR---------SHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTE------- 3134
+ + T ++++++ + SL + + E
Sbjct: 760 IIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSN 819
Query: 3135 -NPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSP-SPPRSRSEQLVRLKDTTAKL 3192
K +LS+ KK + S+ + + + ++ P ++ E + L DT AK
Sbjct: 820 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 879
Query: 3193 SKGAIPCPAATP------VPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINH 3246
++ + V I +K + + + QIK E ++
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY------ISLAEHEAKMS 933
Query: 3247 AASGSFRESVDAQEEI----RKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVP 3302
+ S S R+ D+ EI RK ++ +H + + + D ++ KV
Sbjct: 934 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE-------IKAQKKELDTIQECIKVKYA 986
Query: 3303 PRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNH 3362
P +S +E R + E + D +E + + E E K N+ + N
Sbjct: 987 PIVS-----FEECERKFKATEKELKDQLSEQTQKYSVSE----EEVKKNK------QEND 1031
Query: 3363 NIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGM 3422
+++E T K+ T L S E+ + K + + + LS+ ++ +
Sbjct: 1032 KLKKEIFTLQKDLRDKTVLIEKS---------HEMERALSRKTDELNKQLKDLSQKYTEV 1082
Query: 3423 DAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQK 3482
+ ++VE K +S A ++ +H P + + + ++ KE K+ Q+
Sbjct: 1083 KNVKEKLVEENAKQTS--EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1140
Query: 3483 TWQESGRVFKGLGYATAD--------ASATEMRTTFQEE----SAFISEAAAPRQGNMYT 3530
+++ + L + A +++ F++E A + E Q M
Sbjct: 1141 CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
Query: 3531 LSKDSLSNGVPSGRQA 3546
+SK L + V + +QA
Sbjct: 1201 VSK--LQSEVQNTKQA 1214
Score = 38.5 bits (88), Expect = 0.12
Identities = 148/787 (18%), Positives = 313/787 (39%), Gaps = 135/787 (17%)
Query: 1181 EVKEIKPVEMDIQAGDVSSM------RYKFENQSLDSISSSSEEVLKKIKTL-KTEDIQK 1233
E K K EM+ QA ++S+ KFEN SS S EV +K K L + E +
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMK----SSLSNEVNEKAKKLVEMEREHE 658
Query: 1234 GNVLNCRWLFENQPIDKIKESQ----EGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKE 1289
++ R L K K +Q E E VK+ + + G++ K T +++
Sbjct: 659 KSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITEL-TLKNQTLQK 717
Query: 1290 ESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRG 1349
E + + + +E Q + M PL +D + S+ + +++ +
Sbjct: 718 EIEKVYLDNKLLKE--QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Query: 1350 TRWLFETKPL----DSINKS----ETVYVIKSVTQEDI---------QKGDVSSVRYRF- 1391
T E + L DS++K ETV+V +++I K +S ++ +
Sbjct: 776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 835
Query: 1392 -ETQPLDQISEESHNIMPSIDH--------------IQGGNVKTSRQFFE-SENFDKNN- 1434
+ + + ++ E+ N+ + + + KT+R+ + + F+ N
Sbjct: 836 EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 895
Query: 1435 -YIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWL 1493
+++ NEI K N++ +T ++++ E + ++ + + + + Q++
Sbjct: 896 EFVKIKDKNEILKRNLE--------NTQNQIKAEYI------SLAEHEAKMSSLSQSMRK 941
Query: 1494 FENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIK 1553
++ + + KG +EEI LH E + +K E+
Sbjct: 942 VQDSNAEILANYRKG-----QEEI--------------VTLHA--EIKAQKKEL------ 974
Query: 1554 ETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLL 1613
+T+++ KV AP + E E + + +L +Q S + QK + +++
Sbjct: 975 DTIQECI--KVKYAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNK---- 1027
Query: 1614 SKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSV 1673
+ D ++EI +++ + KT L+ +S E ++ + +K+L + V
Sbjct: 1028 QENDKLKKEIFTLQKDLRD----KTVLIEKSHEMERALSRKTD-ELNKQLKDLSQKYTEV 1082
Query: 1674 K--KGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISE 1731
K K L++E+ K + L + +E+ E + + TI NL
Sbjct: 1083 KNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENL----------- 1131
Query: 1732 RAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLL 1791
+ ++ + +R + T + L L + N ++ + KE +V K
Sbjct: 1132 KEELKSMQRCYEKEQQTVTKLHQL-----LENQKNSSVPLAEHLQIKEAFEKEVGIIKAS 1186
Query: 1792 LKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQA 1851
L++++ + + E + +V NT + + K + K DL + ++SL++
Sbjct: 1187 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEK 1246
Query: 1852 ---VNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNT 1908
+N+K EE++ KE S + ++ +I +I+ E +K+ T
Sbjct: 1247 LANLNRKYEEVCEEVLHAKK-------KEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 1909 KTEILKK 1915
TE+ ++
Sbjct: 1300 ITELQRR 1306
Score = 35.0 bits (79), Expect = 1.3
Identities = 34/195 (17%), Positives = 86/195 (44%), Gaps = 5/195 (2%)
Query: 242 MMEESEMCAVP-GGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSS 300
++E + +VP ++K+ FE E+ + + + + + QN+ E+ + S+V ++ +
Sbjct: 1155 LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1214
Query: 301 QEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKV 360
+ +E + K +++ + + E++ ++ ++ V E V+ + E K
Sbjct: 1215 LKKLET-REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Query: 361 STKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQR 420
+LL E+ +++ DK +TT + + +E+ K T ++ +R
Sbjct: 1274 EKELLHFSIEQEIKDQKERCDKSLTTIT---ELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 421 KETSTTRYSDHSVTS 435
+ + S + TS
Sbjct: 1331 LKQALNGLSQLTYTS 1345
Score = 32.7 bits (73), Expect = 6.6
Identities = 47/230 (20%), Positives = 89/230 (38%), Gaps = 42/230 (18%)
Query: 1769 LTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTF 1828
L K E E+ + E K L Q E + ++ + T ++ +
Sbjct: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 1829 GKIPKEEI--IKGDLTSTLNSLSQAVN---------QKTVTKTEEIIK------------ 1865
+P E++ +K L T+ +L + + Q+TVTK ++++
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 1866 -----------GNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKA-TNTKTEIL 1913
G + A+L+ +E S E + + +++ + L+K T ++
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKME--EVSKLQSEVQNTKQALKKLETREVVDLS 1227
Query: 1914 KKELLKDDLETSLRSLKE----AQRSFKEVHKEGVIKKDAKAVMAGSSGE 1959
K + K DLET + SL E R ++EV +E V+ K + A E
Sbjct: 1228 KYKATKSDLETQISSLNEKLANLNRKYEEVCEE-VLHAKKKEISAKDEKE 1276
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 57.0 bits (136), Expect = 3e-07
Identities = 45/156 (28%), Positives = 55/156 (35%), Gaps = 18/156 (11%)
Query: 2288 PLPPPSPPPPPPSNASSEIEFPLPPPPPL--MMFPEKNGFLP-----SLSTEKIKAEFES 2340
PLPPP PPPPPP P PPPPPL P P S T A S
Sbjct: 627 PLPPPPPPPPPPPPP------PPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS 680
Query: 2341 FPGLPLPPPPVDEKSERESSSM-----FLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQ 2395
P PPV + + + +PPPPPP P P ++ P + Q
Sbjct: 681 GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQF 740
Query: 2396 YSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPK 2431
+ Q PPP +P P P+
Sbjct: 741 SAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ 776
Score = 54.7 bits (130), Expect = 2e-06
Identities = 52/172 (30%), Positives = 68/172 (39%), Gaps = 34/172 (19%)
Query: 2283 KESECPLPPPSPPPPPPSNASS-EIEFPLPPPPPLM----MFPEKNGFLP-SLSTEKIKA 2336
++S C PPPSP P PS +FP PP PP M + P P S K K
Sbjct: 843 QQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKP 902
Query: 2337 EFES----FPGLPLPPPPVDEKSERESSSMFLPPPPPPTPS-QKPAHLLSSSAPEKHSGD 2391
+++ P PPPP ESS +F PPPP P P+ P +S P+K
Sbjct: 903 KWQPSSIPVPSPDFPPPPP------ESSLVFPPPPPSPVPAPPPPPPPTASPTPDK---- 952
Query: 2392 FMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPK 2443
S S + + G PPPT P+ IK + P+
Sbjct: 953 ----------SGSPGKKTSKTSSPGGKKPPPT---PQRNSSIKSSSGAEHPE 991
Score = 52.4 bits (124), Expect = 8e-06
Identities = 39/153 (25%), Positives = 63/153 (41%), Gaps = 19/153 (12%)
Query: 2291 PPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPP 2350
PP+PPPPPP I PLPP P P+ +P+ ++ K A + P P PP
Sbjct: 760 PPTPPPPPP------IPAPLPPQAP----PKPLVTIPAPTSTKTVAPVVTQAAPPTPTPP 809
Query: 2351 VDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAK 2410
V ++ + PP PPTP P + + P++ Q + K + +
Sbjct: 810 VPPAKKQPAFPASYIPPSPPTP---PVPVPPPTLPKQ------QSFCAKPPPSPLSPVPS 860
Query: 2411 IITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPK 2443
++ PPP P + +K + +P+
Sbjct: 861 VVKQIASQFPPPPTPPAMESQPLKPVPANVAPQ 893
Score = 49.3 bits (116), Expect = 7e-05
Identities = 41/114 (35%), Positives = 49/114 (42%), Gaps = 17/114 (14%)
Query: 2285 SECPLPPPSPPPPPPSNA-------SSEIEFPLPPPPPLMM-FPEKNGFLPSLSTEKIKA 2336
S P+P P PPPPP ++ S + P PPPPP P+K+G P T K
Sbjct: 907 SSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG-SPGKKTSK--- 962
Query: 2337 EFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSG 2390
S PG PPP S +SSS P P PS L+S P SG
Sbjct: 963 --TSSPGGKKPPPTPQRNSSIKSSS-GAEHPEPKRPSVD--SLVSKFTPPAESG 1011
Score = 48.1 bits (113), Expect = 2e-04
Identities = 34/135 (25%), Positives = 56/135 (41%), Gaps = 2/135 (1%)
Query: 2292 PSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPV 2351
P PPPPPP L P P P+ + P L +++ + P P PPPP+
Sbjct: 710 PPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI 769
Query: 2352 DEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKI 2411
++ L P PT ++ A +++ +AP + ++K+ + +
Sbjct: 770 PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP--AKKQPAFPASYIPPS 827
Query: 2412 ITGKTGVLPPPTLPK 2426
+PPPTLPK
Sbjct: 828 PPTPPVPVPPPTLPK 842
Score = 45.4 bits (106), Expect = 0.001
Identities = 59/235 (25%), Positives = 86/235 (36%), Gaps = 24/235 (10%)
Query: 2290 PPPSPPPPPPSNASSEIEFP---LPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPL 2346
P P+PP PP A + FP +PP PP P LP + K P PL
Sbjct: 804 PTPTPPVPP---AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKP-----PPSPL 855
Query: 2347 PPPPVDEKSERESSSMFLPPPPPPTPSQK-----PAHLLSSSAPEKHSGDFMQQYSQKEA 2401
P P ++ +S F PPP PP + PA++ S P + Q S
Sbjct: 856 SPVP---SVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVP 912
Query: 2402 SNS---QNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSP-KVELATSLSDMECKI 2457
S ++ ++ P P P P P SP K TS +
Sbjct: 913 SPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPP 972
Query: 2458 TTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRK 2512
T + + + +EH E K+ + SL + +S + T+P +AP K
Sbjct: 973 PTPQRNSSIKSSSGAEHPEPKRPSVD-SLVSKFTPPAESGSPSKETLPPPAAPPK 1026
Score = 43.9 bits (102), Expect = 0.003
Identities = 44/155 (28%), Positives = 53/155 (34%), Gaps = 59/155 (38%)
Query: 2289 LPPPSPPPP--PPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPL 2346
+PP SP P P AS PPPPP P
Sbjct: 606 VPPLSPQPKIVTPYTASQPSPPLPPPPPP-----------------------------PP 636
Query: 2347 PPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAP--------------EKHSGDF 2392
PPPP PPPPPP PSQ A S+AP +HSG
Sbjct: 637 PPPPPP------------PPPPPPLPSQS-APSAGSAAPMFVKYSTITRLQNASQHSGAL 683
Query: 2393 MQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKP 2427
+ SQ+ + +I+ GV+PPP P P
Sbjct: 684 FKP-PTPPVMQSQSVKPQILVPPNGVVPPPPPPPP 717
Score = 38.5 bits (88), Expect = 0.12
Identities = 32/100 (32%), Positives = 39/100 (39%), Gaps = 5/100 (5%)
Query: 3110 PPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRAN 3169
PPPS PP P T T ++ +P K S P P+R S KS
Sbjct: 930 PPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSS--SGA 987
Query: 3170 TSPSPPRSRSEQLVRLKDTTAKL---SKGAIPCPAATPVP 3206
P P R + LV A+ SK +P PAA P P
Sbjct: 988 EHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027
Score = 38.1 bits (87), Expect = 0.16
Identities = 45/173 (26%), Positives = 58/173 (33%), Gaps = 50/173 (28%)
Query: 2278 PENNVKESECPLPPPSPPPPPPSNASS----EIEFPLPPPPPLMMFPEKNGFLPSLSTEK 2333
P V + P PP+ P SS +FP PPP ++FP
Sbjct: 882 PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP------------- 928
Query: 2334 IKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFM 2393
P PP PV PPPPPPT S P S +P K +
Sbjct: 929 -----------PPPPSPVPAP----------PPPPPPTASPTPD---KSGSPGKKTSKTS 964
Query: 2394 QQYSQKEASNSQ-NSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVE 2445
+K Q NS K +G P+PK P + + F+P E
Sbjct: 965 SPGGKKPPPTPQRNSSIKSSSGAEH-------PEPKRPS-VDSLVSKFTPPAE 1009
Score = 34.3 bits (77), Expect = 2.3
Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 14/133 (10%)
Query: 3117 RPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPS--- 3173
+PP+P + +S + P + P PPP P S +++ A +PS
Sbjct: 685 KPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-----PPPPTPGSAMAQLKPAPCAPSLPQ 739
Query: 3174 ----PPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIET 3229
PP + Q+ + P PA P K I +P + + + T
Sbjct: 740 FSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVT 799
Query: 3230 RGRDSPPTITIPV 3242
+ +PPT T PV
Sbjct: 800 QA--APPTPTPPV 810
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 56.2 bits (134), Expect = 6e-07
Identities = 58/232 (25%), Positives = 80/232 (34%), Gaps = 59/232 (25%)
Query: 2273 PINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTE 2332
P F +++ S P PPP PPPPPP P PPPPP P P++ +
Sbjct: 2390 PRPFFRSSSLDISAQPPPPPPPPPPPP---------PPPPPPPPPPLPPPTSPKPTILPK 2440
Query: 2333 KIKAEFESFPGLPLPPPPVDEKSERESSSMF-------------LPPPPPPTPSQKPAHL 2379
K + + P D + E++++ PPP PP PS P+ L
Sbjct: 2441 K---KLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGL 2497
Query: 2380 LSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPK--HIKDNK 2437
+ + PE PP PKP +P+
Sbjct: 2498 VFTHRPEPSK-------------------------------PPIAPKPVIPQLPTTTQKP 2526
Query: 2438 NDFSPKVELATSLSDMECKITTSKDQKKVMVMTS-SEHTETKQNVISKSLDE 2488
D PK + S M + TS D K + S H+ SKSL E
Sbjct: 2527 TDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTE 2578
Score = 45.4 bits (106), Expect = 0.001
Identities = 200/999 (20%), Positives = 341/999 (34%), Gaps = 154/999 (15%)
Query: 2288 PLPPPSPPPP---PPSNASSEIEFPLPPPPPLMMF-PEKNGFLPSLSTEKIKAEFESFPG 2343
PL PP+ P PPS + PL L++ PEK F + F
Sbjct: 566 PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN- 624
Query: 2344 LPLPPPPVDEKSE---------RESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQ 2394
P P + E E R P P P P K A + ++SA K S Q
Sbjct: 625 ---PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ 681
Query: 2395 QYSQKEASNSQN-SQAKIITGKTGVLPPPTL-----PKPKLPKHIKDNKNDFSPKVELAT 2448
+K+A+ Q+ S+A ++ PTL K K P PK
Sbjct: 682 TSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP 741
Query: 2449 SLSDMECKITTSKDQKKVMV-----MTSSEHTETKQNVISKSLDERKQ------LSIDSA 2497
S D + + K ++ MV + SS TK ++ S + + + L DSA
Sbjct: 742 SEQD-KAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 2498 NCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEE 2557
S + P P ++++P +S P + P +E K ++Q +
Sbjct: 801 K-PSQSFP----PTGEKVSPF-------DSKAIPRPASDSKIISHPGPSSESKGQKQVDP 848
Query: 2558 IEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSN 2617
++K+++ K Q++ + K MP Q SP Q
Sbjct: 849 VQKKEEPK------KAQTKMSPKPDA-KPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901
Query: 2618 AR----ILGVCSDNQLS--TTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKS 2671
+R LG +D S TT ETV K + + Q QS
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH-SQSGP 960
Query: 2672 ACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYES 2731
+KQ+ +Q P+S +P K+I P T E
Sbjct: 961 GAPMKQAPAPSQPPTSQGP--------PKSTGQAPPAPAKSI--PVKKETKAPAAEKLEP 1010
Query: 2732 HKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTV--------- 2782
+Q+ +T T+K+ K +++ T K L + + PK E +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070
Query: 2783 ----QLPTESIQKNQ----------------EDKLKMVPRKQREFSG--SDRGKLP---- 2816
T + KNQ ++ L + + QR SG D K+P
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130
Query: 2817 ------------GSEEKNQGPSMIG--RKEERLITERKHEHLKNKSAPKVVKQKVIDAHL 2862
S +K P + +K+E+ + + + K + +K+
Sbjct: 1131 GPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVT 1190
Query: 2863 DSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSN---TKDSKQE 2919
Q Q + + A + E K LP+ + EE+ +++ ++K + T + K+
Sbjct: 1191 TDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE--KIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 2920 ITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTL 2979
+ + K+ S+ +E + D K + I E +++ RV + K + L
Sbjct: 1249 LPEAKT--SAPEEQKHDLLKSQVQIAE--------EKLEGRVAPKTVQEGKQPQTKMEGL 1298
Query: 2980 LNTIPGWLISEDKRE------------YAVHIAMENNLEKVKEEITHIKTQAEDMLVSYE 3027
+ P L ED + A +E EK ++E T + S +
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358
Query: 3028 NIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEK---TVQHQV 3084
+ T S + SL T K ++ K+S +E+ + ++ V
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEK--DILKGLKKDSFSQESSPSSPSDLAKLESTV 1416
Query: 3085 AAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFI-TIESTARRTE-NPTKNELS 3142
+ EA + E K + P K + + + T+E T E ++ E
Sbjct: 1417 LSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERK 1476
Query: 3143 QSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQ 3181
+ KKDS + P + +KSE T+ P E+
Sbjct: 1477 DTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEE 1515
Score = 43.5 bits (101), Expect = 0.004
Identities = 200/1041 (19%), Positives = 365/1041 (35%), Gaps = 170/1041 (16%)
Query: 2267 MERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFL 2326
+++ P + + K P+P SP PP P + + P P P P++
Sbjct: 849 VQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ-TVPTPQQSPK---PQEQSRR 904
Query: 2327 PSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPE 2386
SL+ I +S P P V K +S+F SQ + ++ P
Sbjct: 905 FSLNLGSITDAPKSQP--TTPQETVTGKLFGFGASIF---------SQASNLISTAGQPG 953
Query: 2387 KHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIK-DNKNDFSPKVE 2445
HS ++ + SQ ++ TG PP + K K PK E
Sbjct: 954 PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAE 1013
Query: 2446 LATSL--SDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHT 2503
A ++ ++ E K KD K + E ++ V+ L++ + C +
Sbjct: 1014 QAPTVKRTETEKKPPPIKDSKSLT-------AEPQKAVLPTKLEKSPKPESTCPLCKTEL 1066
Query: 2504 VPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQ---QKEEIEK 2560
G+ P K+ + NP P++ + + L + + R Q +I K
Sbjct: 1067 NIGSKDPPNFNTCTECKNQVC--NLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRK 1124
Query: 2561 QKQESSYYNI----VKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQS 2616
S V T+S +Q + ++K +EV ++E +++ + S
Sbjct: 1125 MPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVK---TEAEKVILEKVKETLS 1181
Query: 2617 NARILG-VCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRD----IMQSKS 2671
+I V +D + + E A L E+K + +E S + + + K
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKP 1241
Query: 2672 ACEIKQSHQECSTQQTQQKKY---LEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHS 2728
E K+ E T +++K+ Q+ + + K + KT++ T E S
Sbjct: 1242 TPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEK-LEGRVAPKTVQEGKQPQTKMEGLPS 1300
Query: 2729 YESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTES 2788
E D T KT K + C+ K E P KEK TE
Sbjct: 1301 GTPQSLPKEDDKTT-------KTIKEQPQPPCTAKPDQVE-----PGKEK-------TEK 1341
Query: 2789 IQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKS 2848
+ P+ + S + S + PS+I E+ ++ K + +S
Sbjct: 1342 EDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES 1401
Query: 2849 APKVVKQKVIDAHLDSQTQNFQQTQIQT-AESKAEHKKLP---QPYNSLQEEKCL----- 2899
+P A L+S + + Q T A+ K+E K P P +EK
Sbjct: 1402 SPSSPSDL---AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSET 1458
Query: 2900 --------EVKGIQEKQVFSNTKDSKQEITQNKSF----------------FSSVKES-- 2933
E+K QE++ + KDS+Q+I +K + SV+ES
Sbjct: 1459 LEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSE 1518
Query: 2934 -----------------------QRDDGKGALNIVEFLRK-------------------- 2950
+++D +G+ +F+RK
Sbjct: 1519 SENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFI 1578
Query: 2951 REELQQILSRVKQFEAEPNKSGLKTF---QTLLNTIPGWLISEDK-REYAVHIAMENNLE 3006
R +L++I S + + E K K L I ED R ++ H + +
Sbjct: 1579 RNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 3007 KVKE-EITHIKTQ-AEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNN 3064
+ E + K+Q +E+++V+ ++ +K ++ E+S K ++++
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSA--ESSQKKTSLYFDEE 1696
Query: 3065 KNSEQKENKIAKEKTVQHQVAAH-HEATVRSHVKTHQEIKLDDSNIPPPSLKT------- 3116
E + + E + + ++ H ++ LD+ + PS K
Sbjct: 1697 PELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQR 1756
Query: 3117 ----RPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIH----RA 3168
RP P TIE ++ E + EL + +K +E R+ S+KS+ RA
Sbjct: 1757 KARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRA 1816
Query: 3169 NTSPSPPRSRSEQLVRLKDTT 3189
P++ L ++D +
Sbjct: 1817 QRRRERPKTPPSNLSPIEDAS 1837
Score = 42.4 bits (98), Expect = 0.008
Identities = 172/857 (20%), Positives = 303/857 (35%), Gaps = 175/857 (20%)
Query: 2183 QKQTLLKQETKYSNKDIK-KKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKK 2241
Q T+ + ET+ IK K++ +P +LP T+++ S K +T
Sbjct: 1014 QAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP--------TKLEKSPKPESTCPLC--- 1062
Query: 2242 RETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESE--------------- 2286
+T++++ S+D NT T K + N FNP ++ E +
Sbjct: 1063 -KTELNIGSKD-PPNFNTCTECK---NQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG 1117
Query: 2287 ----------CPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKN-----------GF 2325
P P + P P P+ +SS+ + +PP L+ E+
Sbjct: 1118 QLGDIRKMPPAPSGPKASPMPVPTESSSQ-KTAVPPQVKLVKKQEQEVKTEAEKVILEKV 1176
Query: 2326 LPSLSTEKI-------------KAEFESFPGL----PLPPP----PVDEKSERESSSMFL 2364
+LS EKI K E + L PLP P +EK E L
Sbjct: 1177 KETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL 1236
Query: 2365 PPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTL 2424
P +K +SAPE+ D ++ S Q ++ K+ G + P T+
Sbjct: 1237 EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK-------SQVQIAEEKL----EGRVAPKTV 1285
Query: 2425 PKPKLPKHIKDNKNDFSPKVELATSLSDMECKIT-TSKDQ-------KKVMVMTSSEHTE 2476
+ K P+ + +P+ SL + K T T K+Q K V E TE
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQ-----SLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTE 1340
Query: 2477 TKQNVISKSLDERKQ---------LSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPES 2527
+ + S ++ + S D + +P +K I +K SF +
Sbjct: 1341 KEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQE 1400
Query: 2528 SGQQNPKPYMRKFKTPLMI--------AEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQH 2579
S +P + T L I A+EK ++ + E ++ ++ S+
Sbjct: 1401 SSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLE 1460
Query: 2580 ITEVEKE-------------------MPLQKTNEEVSLSGIDSECTVVQP--SPGSQSNA 2618
IT E+E +P K ++E S +D T +P S S +
Sbjct: 1461 ITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKS-EFVDDITTRREPYDSVEESSES 1519
Query: 2619 RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACE--IK 2676
V + ++ + + + E++D ++K++++ S D S S + I+
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIR 1579
Query: 2677 QSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQS 2736
+E S+ QKK ++K K +L T + D + H
Sbjct: 1580 NQLKEISSSTESQKK-------EETKGKGKITAGKHRRLTRKSSTSIDED-AGRRHSWHD 1631
Query: 2737 EIDVQTFTKKQYLKTKKTEA--STECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQE 2794
E D + F + LK ++T++ S E R ++ + + + ES QK
Sbjct: 1632 E-DDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTS 1690
Query: 2795 DKLKMVPRKQREF---SGSDRGKLPGSEE-------KNQGPSMIGRKEERLITERKHEHL 2844
P + E S DR + GS P+ + +E + H+
Sbjct: 1691 LYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKG 1750
Query: 2845 KNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQE-EKCLEVKG 2903
++K K + + T E +E ++L + L+E EK E++
Sbjct: 1751 ESKQQRKARHRP-------------HGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 2904 IQEKQVFSNTKDSKQEI 2920
Q K +K K E+
Sbjct: 1798 QQRKSSSKKSKKDKDEL 1814
Score = 37.4 bits (85), Expect = 0.27
Identities = 96/442 (21%), Positives = 156/442 (35%), Gaps = 88/442 (19%)
Query: 2342 PGLPLPPP--PVDEKSERESSSMFLPPPPPPTPSQ-KPAHLLSSSAPEKHSGD---FMQQ 2395
PG PPP P K + PPP P P++ P S+ P + G QQ
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543
Query: 2396 YSQKEASNSQNSQAKIITGKTGVLPPPTL-------PKPKLPKHIKD--NKNDFSPKV-E 2445
S + S Q+++ TG L PPT+ P LPK I N + V E
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603
Query: 2446 LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVP 2505
A + EC+ T + + H + + + ++ L D A VP
Sbjct: 604 KANFNTCTECQTTVC----SLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLA-----PVP 654
Query: 2506 GTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQES 2565
+ P+ K AP+ + + +SS Q P + +K K+++ K +
Sbjct: 655 SSPQPKLK-TAPVTTTSAVSKSSPQ------------PQQTSPKKDAAPKQDLSKAPEPK 701
Query: 2566 SYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCS 2625
+VK + + + K+ P E SLS +P+P
Sbjct: 702 KPPPLVKQPTLHGSPSAKAKQPP-----EADSLS---------KPAP------------- 734
Query: 2626 DNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQ 2685
P+ + ++DK K K +++ + D++ S SA K Q
Sbjct: 735 --------PKEPSVPSEQDKAPVADDKPKQPK-MVKPTTDLVSSSSA-TTKPDIPSSKVQ 784
Query: 2686 QTQQKKYLEQLHLPQSKP----------ISPNFKVKTIKLPTLDHTLNETDHSYESHKQQ 2735
++K L +KP +SP F K I P D + H S + +
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP-FDSKAIPRPASDSKI--ISHPGPSSESK 841
Query: 2736 SEIDVQTFTKKQYLKTKKTEAS 2757
+ V KK+ K +T+ S
Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMS 863
Score = 35.8 bits (81), Expect = 0.78
Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 10/148 (6%)
Query: 346 ETVIDTPEDEEIPKVSTKLL---KEQFEKSAQEK---ILYSDKEMTTPAKQIKTESEYEE 399
E+V+ PE VST LL K+ +K+ +E I+ E K++ E+E +
Sbjct: 2275 ESVVPKPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKEL--EAERTK 2332
Query: 400 TFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSV--TSSTLAQINATSSGMTEEFPPPPP 457
+ +V +S ++ +++ STT ++ +Q+ + S ++ P P
Sbjct: 2333 SSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRP 2392
Query: 458 DVLQTSVDVTAFSQSPELPSPPRRLPVP 485
+S+D++A P P PP P P
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPP 2420
Score = 33.9 bits (76), Expect = 2.9
Identities = 53/258 (20%), Positives = 92/258 (35%), Gaps = 32/258 (12%)
Query: 2291 PPSPPPPPPSNASSEIEFP--LPPPP----PLMMFPEKNGFLPSLSTEKIKAE---FESF 2341
P PPP P +A + P PPP P P++ G S + A+ +
Sbjct: 486 PAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPS 545
Query: 2342 PGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAH-LLSSSAPEKHSGDFMQQYSQKE 2400
P P S+ S PP P+ Q P+ L + P ++ + + +K
Sbjct: 546 PAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605
Query: 2401 ASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTS 2460
N+ + G P P H+ + K ++ +L + +S
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNP---------HLTEVKEWLCLNCQMKRALGGDLAPVPSS 656
Query: 2461 KDQK-KVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLI 2519
K K +T++ + +SKS + +Q S + + AP K+ PL+
Sbjct: 657 PQPKLKTAPVTTT-------SAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKPPPLV 707
Query: 2520 KS---HSFPESSGQQNPK 2534
K H P + +Q P+
Sbjct: 708 KQPTLHGSPSAKAKQPPE 725
Score = 32.3 bits (72), Expect = 8.6
Identities = 40/155 (25%), Positives = 51/155 (32%), Gaps = 29/155 (18%)
Query: 2285 SECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGL 2344
S+ P+ P+P PP E P P PP PS T+ + + PG
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ---------PSGLTKPLAQQ----PGT 348
Query: 2345 PLPP--PPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGD---FMQQYSQK 2399
PP PP K PP P P++ PA S P Q
Sbjct: 349 VKPPVQPPGTTK----------PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398
Query: 2400 EASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIK 2434
+ Q AK T + G P P +P L K
Sbjct: 399 KTPAQQPGPAKPPTQQVGT-PKPLAQQPGLQSPAK 432
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 56.2 bits (134), Expect = 6e-07
Identities = 58/232 (25%), Positives = 80/232 (34%), Gaps = 59/232 (25%)
Query: 2273 PINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTE 2332
P F +++ S P PPP PPPPPP P PPPPP P P++ +
Sbjct: 2390 PRPFFRSSSLDISAQPPPPPPPPPPPP---------PPPPPPPPPPLPPPTSPKPTILPK 2440
Query: 2333 KIKAEFESFPGLPLPPPPVDEKSERESSSMF-------------LPPPPPPTPSQKPAHL 2379
K + + P D + E++++ PPP PP PS P+ L
Sbjct: 2441 K---KLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGL 2497
Query: 2380 LSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPK--HIKDNK 2437
+ + PE PP PKP +P+
Sbjct: 2498 VFTHRPEPSK-------------------------------PPIAPKPVIPQLPTTTQKP 2526
Query: 2438 NDFSPKVELATSLSDMECKITTSKDQKKVMVMTS-SEHTETKQNVISKSLDE 2488
D PK + S M + TS D K + S H+ SKSL E
Sbjct: 2527 TDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTE 2578
Score = 45.4 bits (106), Expect = 0.001
Identities = 200/999 (20%), Positives = 341/999 (34%), Gaps = 154/999 (15%)
Query: 2288 PLPPPSPPPP---PPSNASSEIEFPLPPPPPLMMF-PEKNGFLPSLSTEKIKAEFESFPG 2343
PL PP+ P PPS + PL L++ PEK F + F
Sbjct: 566 PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN- 624
Query: 2344 LPLPPPPVDEKSE---------RESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQ 2394
P P + E E R P P P P K A + ++SA K S Q
Sbjct: 625 ---PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ 681
Query: 2395 QYSQKEASNSQN-SQAKIITGKTGVLPPPTL-----PKPKLPKHIKDNKNDFSPKVELAT 2448
+K+A+ Q+ S+A ++ PTL K K P PK
Sbjct: 682 TSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP 741
Query: 2449 SLSDMECKITTSKDQKKVMV-----MTSSEHTETKQNVISKSLDERKQ------LSIDSA 2497
S D + + K ++ MV + SS TK ++ S + + + L DSA
Sbjct: 742 SEQD-KAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 2498 NCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEE 2557
S + P P ++++P +S P + P +E K ++Q +
Sbjct: 801 K-PSQSFP----PTGEKVSPF-------DSKAIPRPASDSKIISHPGPSSESKGQKQVDP 848
Query: 2558 IEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSN 2617
++K+++ K Q++ + K MP Q SP Q
Sbjct: 849 VQKKEEPK------KAQTKMSPKPDA-KPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901
Query: 2618 AR----ILGVCSDNQLS--TTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKS 2671
+R LG +D S TT ETV K + + Q QS
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH-SQSGP 960
Query: 2672 ACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYES 2731
+KQ+ +Q P+S +P K+I P T E
Sbjct: 961 GAPMKQAPAPSQPPTSQGP--------PKSTGQAPPAPAKSI--PVKKETKAPAAEKLEP 1010
Query: 2732 HKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTV--------- 2782
+Q+ +T T+K+ K +++ T K L + + PK E +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070
Query: 2783 ----QLPTESIQKNQ----------------EDKLKMVPRKQREFSG--SDRGKLP---- 2816
T + KNQ ++ L + + QR SG D K+P
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130
Query: 2817 ------------GSEEKNQGPSMIG--RKEERLITERKHEHLKNKSAPKVVKQKVIDAHL 2862
S +K P + +K+E+ + + + K + +K+
Sbjct: 1131 GPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVT 1190
Query: 2863 DSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSN---TKDSKQE 2919
Q Q + + A + E K LP+ + EE+ +++ ++K + T + K+
Sbjct: 1191 TDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE--KIRSEEKKPLLEEKKPTPEDKKL 1248
Query: 2920 ITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTL 2979
+ + K+ S+ +E + D K + I E +++ RV + K + L
Sbjct: 1249 LPEAKT--SAPEEQKHDLLKSQVQIAE--------EKLEGRVAPKTVQEGKQPQTKMEGL 1298
Query: 2980 LNTIPGWLISEDKRE------------YAVHIAMENNLEKVKEEITHIKTQAEDMLVSYE 3027
+ P L ED + A +E EK ++E T + S +
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358
Query: 3028 NIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEK---TVQHQV 3084
+ T S + SL T K ++ K+S +E+ + ++ V
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEK--DILKGLKKDSFSQESSPSSPSDLAKLESTV 1416
Query: 3085 AAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFI-TIESTARRTE-NPTKNELS 3142
+ EA + E K + P K + + + T+E T E ++ E
Sbjct: 1417 LSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERK 1476
Query: 3143 QSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQ 3181
+ KKDS + P + +KSE T+ P E+
Sbjct: 1477 DTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEE 1515
Score = 43.5 bits (101), Expect = 0.004
Identities = 200/1041 (19%), Positives = 365/1041 (35%), Gaps = 170/1041 (16%)
Query: 2267 MERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFL 2326
+++ P + + K P+P SP PP P + + P P P P++
Sbjct: 849 VQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ-TVPTPQQSPK---PQEQSRR 904
Query: 2327 PSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPE 2386
SL+ I +S P P V K +S+F SQ + ++ P
Sbjct: 905 FSLNLGSITDAPKSQP--TTPQETVTGKLFGFGASIF---------SQASNLISTAGQPG 953
Query: 2387 KHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIK-DNKNDFSPKVE 2445
HS ++ + SQ ++ TG PP + K K PK E
Sbjct: 954 PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAE 1013
Query: 2446 LATSL--SDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHT 2503
A ++ ++ E K KD K + E ++ V+ L++ + C +
Sbjct: 1014 QAPTVKRTETEKKPPPIKDSKSLT-------AEPQKAVLPTKLEKSPKPESTCPLCKTEL 1066
Query: 2504 VPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQ---QKEEIEK 2560
G+ P K+ + NP P++ + + L + + R Q +I K
Sbjct: 1067 NIGSKDPPNFNTCTECKNQVC--NLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRK 1124
Query: 2561 QKQESSYYNI----VKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQS 2616
S V T+S +Q + ++K +EV ++E +++ + S
Sbjct: 1125 MPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVK---TEAEKVILEKVKETLS 1181
Query: 2617 NARILG-VCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRD----IMQSKS 2671
+I V +D + + E A L E+K + +E S + + + K
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKP 1241
Query: 2672 ACEIKQSHQECSTQQTQQKKY---LEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHS 2728
E K+ E T +++K+ Q+ + + K + KT++ T E S
Sbjct: 1242 TPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEK-LEGRVAPKTVQEGKQPQTKMEGLPS 1300
Query: 2729 YESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTES 2788
E D T KT K + C+ K E P KEK TE
Sbjct: 1301 GTPQSLPKEDDKTT-------KTIKEQPQPPCTAKPDQVE-----PGKEK-------TEK 1341
Query: 2789 IQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKS 2848
+ P+ + S + S + PS+I E+ ++ K + +S
Sbjct: 1342 EDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES 1401
Query: 2849 APKVVKQKVIDAHLDSQTQNFQQTQIQT-AESKAEHKKLP---QPYNSLQEEKCL----- 2899
+P A L+S + + Q T A+ K+E K P P +EK
Sbjct: 1402 SPSSPSDL---AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSET 1458
Query: 2900 --------EVKGIQEKQVFSNTKDSKQEITQNKSF----------------FSSVKES-- 2933
E+K QE++ + KDS+Q+I +K + SV+ES
Sbjct: 1459 LEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSE 1518
Query: 2934 -----------------------QRDDGKGALNIVEFLRK-------------------- 2950
+++D +G+ +F+RK
Sbjct: 1519 SENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFI 1578
Query: 2951 REELQQILSRVKQFEAEPNKSGLKTF---QTLLNTIPGWLISEDK-REYAVHIAMENNLE 3006
R +L++I S + + E K K L I ED R ++ H + +
Sbjct: 1579 RNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 3007 KVKE-EITHIKTQ-AEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNN 3064
+ E + K+Q +E+++V+ ++ +K ++ E+S K ++++
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSA--ESSQKKTSLYFDEE 1696
Query: 3065 KNSEQKENKIAKEKTVQHQVAAH-HEATVRSHVKTHQEIKLDDSNIPPPSLKT------- 3116
E + + E + + ++ H ++ LD+ + PS K
Sbjct: 1697 PELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQR 1756
Query: 3117 ----RPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIH----RA 3168
RP P TIE ++ E + EL + +K +E R+ S+KS+ RA
Sbjct: 1757 KARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRA 1816
Query: 3169 NTSPSPPRSRSEQLVRLKDTT 3189
P++ L ++D +
Sbjct: 1817 QRRRERPKTPPSNLSPIEDAS 1837
Score = 42.4 bits (98), Expect = 0.008
Identities = 172/857 (20%), Positives = 303/857 (35%), Gaps = 175/857 (20%)
Query: 2183 QKQTLLKQETKYSNKDIK-KKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKK 2241
Q T+ + ET+ IK K++ +P +LP T+++ S K +T
Sbjct: 1014 QAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP--------TKLEKSPKPESTCPLC--- 1062
Query: 2242 RETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESE--------------- 2286
+T++++ S+D NT T K + N FNP ++ E +
Sbjct: 1063 -KTELNIGSKD-PPNFNTCTECK---NQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG 1117
Query: 2287 ----------CPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKN-----------GF 2325
P P + P P P+ +SS+ + +PP L+ E+
Sbjct: 1118 QLGDIRKMPPAPSGPKASPMPVPTESSSQ-KTAVPPQVKLVKKQEQEVKTEAEKVILEKV 1176
Query: 2326 LPSLSTEKI-------------KAEFESFPGL----PLPPP----PVDEKSERESSSMFL 2364
+LS EKI K E + L PLP P +EK E L
Sbjct: 1177 KETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL 1236
Query: 2365 PPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTL 2424
P +K +SAPE+ D ++ S Q ++ K+ G + P T+
Sbjct: 1237 EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK-------SQVQIAEEKL----EGRVAPKTV 1285
Query: 2425 PKPKLPKHIKDNKNDFSPKVELATSLSDMECKIT-TSKDQ-------KKVMVMTSSEHTE 2476
+ K P+ + +P+ SL + K T T K+Q K V E TE
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQ-----SLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTE 1340
Query: 2477 TKQNVISKSLDERKQ---------LSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPES 2527
+ + S ++ + S D + +P +K I +K SF +
Sbjct: 1341 KEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQE 1400
Query: 2528 SGQQNPKPYMRKFKTPLMI--------AEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQH 2579
S +P + T L I A+EK ++ + E ++ ++ S+
Sbjct: 1401 SSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLE 1460
Query: 2580 ITEVEKE-------------------MPLQKTNEEVSLSGIDSECTVVQP--SPGSQSNA 2618
IT E+E +P K ++E S +D T +P S S +
Sbjct: 1461 ITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKS-EFVDDITTRREPYDSVEESSES 1519
Query: 2619 RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACE--IK 2676
V + ++ + + + E++D ++K++++ S D S S + I+
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIR 1579
Query: 2677 QSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQS 2736
+E S+ QKK ++K K +L T + D + H
Sbjct: 1580 NQLKEISSSTESQKK-------EETKGKGKITAGKHRRLTRKSSTSIDED-AGRRHSWHD 1631
Query: 2737 EIDVQTFTKKQYLKTKKTEA--STECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQE 2794
E D + F + LK ++T++ S E R ++ + + + ES QK
Sbjct: 1632 E-DDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTS 1690
Query: 2795 DKLKMVPRKQREF---SGSDRGKLPGSEE-------KNQGPSMIGRKEERLITERKHEHL 2844
P + E S DR + GS P+ + +E + H+
Sbjct: 1691 LYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKG 1750
Query: 2845 KNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQE-EKCLEVKG 2903
++K K + + T E +E ++L + L+E EK E++
Sbjct: 1751 ESKQQRKARHRP-------------HGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 2904 IQEKQVFSNTKDSKQEI 2920
Q K +K K E+
Sbjct: 1798 QQRKSSSKKSKKDKDEL 1814
Score = 37.4 bits (85), Expect = 0.27
Identities = 96/442 (21%), Positives = 156/442 (35%), Gaps = 88/442 (19%)
Query: 2342 PGLPLPPP--PVDEKSERESSSMFLPPPPPPTPSQ-KPAHLLSSSAPEKHSGD---FMQQ 2395
PG PPP P K + PPP P P++ P S+ P + G QQ
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543
Query: 2396 YSQKEASNSQNSQAKIITGKTGVLPPPTL-------PKPKLPKHIKD--NKNDFSPKV-E 2445
S + S Q+++ TG L PPT+ P LPK I N + V E
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603
Query: 2446 LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVP 2505
A + EC+ T + + H + + + ++ L D A VP
Sbjct: 604 KANFNTCTECQTTVC----SLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLA-----PVP 654
Query: 2506 GTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQES 2565
+ P+ K AP+ + + +SS Q P + +K K+++ K +
Sbjct: 655 SSPQPKLK-TAPVTTTSAVSKSSPQ------------PQQTSPKKDAAPKQDLSKAPEPK 701
Query: 2566 SYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCS 2625
+VK + + + K+ P E SLS +P+P
Sbjct: 702 KPPPLVKQPTLHGSPSAKAKQPP-----EADSLS---------KPAP------------- 734
Query: 2626 DNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQ 2685
P+ + ++DK K K +++ + D++ S SA K Q
Sbjct: 735 --------PKEPSVPSEQDKAPVADDKPKQPK-MVKPTTDLVSSSSA-TTKPDIPSSKVQ 784
Query: 2686 QTQQKKYLEQLHLPQSKP----------ISPNFKVKTIKLPTLDHTLNETDHSYESHKQQ 2735
++K L +KP +SP F K I P D + H S + +
Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP-FDSKAIPRPASDSKI--ISHPGPSSESK 841
Query: 2736 SEIDVQTFTKKQYLKTKKTEAS 2757
+ V KK+ K +T+ S
Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMS 863
Score = 35.8 bits (81), Expect = 0.78
Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 10/148 (6%)
Query: 346 ETVIDTPEDEEIPKVSTKLL---KEQFEKSAQEK---ILYSDKEMTTPAKQIKTESEYEE 399
E+V+ PE VST LL K+ +K+ +E I+ E K++ E+E +
Sbjct: 2275 ESVVPKPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKEL--EAERTK 2332
Query: 400 TFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSV--TSSTLAQINATSSGMTEEFPPPPP 457
+ +V +S ++ +++ STT ++ +Q+ + S ++ P P
Sbjct: 2333 SSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRP 2392
Query: 458 DVLQTSVDVTAFSQSPELPSPPRRLPVP 485
+S+D++A P P PP P P
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPP 2420
Score = 33.9 bits (76), Expect = 2.9
Identities = 53/258 (20%), Positives = 92/258 (35%), Gaps = 32/258 (12%)
Query: 2291 PPSPPPPPPSNASSEIEFP--LPPPP----PLMMFPEKNGFLPSLSTEKIKAE---FESF 2341
P PPP P +A + P PPP P P++ G S + A+ +
Sbjct: 486 PAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPS 545
Query: 2342 PGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAH-LLSSSAPEKHSGDFMQQYSQKE 2400
P P S+ S PP P+ Q P+ L + P ++ + + +K
Sbjct: 546 PAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605
Query: 2401 ASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTS 2460
N+ + G P P H+ + K ++ +L + +S
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNP---------HLTEVKEWLCLNCQMKRALGGDLAPVPSS 656
Query: 2461 KDQK-KVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLI 2519
K K +T++ + +SKS + +Q S + + AP K+ PL+
Sbjct: 657 PQPKLKTAPVTTT-------SAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKPPPLV 707
Query: 2520 KS---HSFPESSGQQNPK 2534
K H P + +Q P+
Sbjct: 708 KQPTLHGSPSAKAKQPPE 725
Score = 32.3 bits (72), Expect = 8.6
Identities = 40/155 (25%), Positives = 51/155 (32%), Gaps = 29/155 (18%)
Query: 2285 SECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGL 2344
S+ P+ P+P PP E P P PP PS T+ + + PG
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ---------PSGLTKPLAQQ----PGT 348
Query: 2345 PLPP--PPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGD---FMQQYSQK 2399
PP PP K PP P P++ PA S P Q
Sbjct: 349 VKPPVQPPGTTK----------PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398
Query: 2400 EASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIK 2434
+ Q AK T + G P P +P L K
Sbjct: 399 KTPAQQPGPAKPPTQQVGT-PKPLAQQPGLQSPAK 432
>gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens]
Length = 1989
Score = 56.2 bits (134), Expect = 6e-07
Identities = 166/808 (20%), Positives = 292/808 (36%), Gaps = 134/808 (16%)
Query: 2039 LEKSLRRLSNSHHKSNVLESGDKTGVWTDTT-GEQHLRDEYMSRQLTSTVSVKNNLTTKE 2097
L + L + + V + + +DTT Q L+D+ + LT +S + L+ K+
Sbjct: 304 LRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDK--EQNLTRRISTSDILSEKK 361
Query: 2098 SDRAVRELKKDDV-FNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDT 2156
EL + + ++QSA K +++ ++ +K+ K+ + +K T T
Sbjct: 362 LGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLT----KTKTVQQKVKTSTKT 417
Query: 2157 QSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMW------ 2210
S+K T KQ L KQ+TK K ++K Q
Sbjct: 418 HSAKKVSTT-----------------AKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQA 460
Query: 2211 ---QLLPVEQDTSNVTEMKVSEKSHNTF------KATNKKRETDVHLKSQDFLMKTNTST 2261
+ E++ + ++ E+ +N F K ++ + +D L+ T++
Sbjct: 461 EEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGG 520
Query: 2262 GLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFP------LPPPPP 2315
G+ N+ +SE P PSP PP + S F LPPPP
Sbjct: 521 GIYQYD-------NYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQ 573
Query: 2316 LMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQK 2375
+ LP LS ++ S LP PP LPP PP P Q
Sbjct: 574 VSS-------LPPLSQPYVEGLCVSLEPLPPLPP--------------LPPLPPEDPEQP 612
Query: 2376 PAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTL----PKPKLPK 2431
P + E+ +++ K +N + + + + + PP L P P+
Sbjct: 613 PKPPFADEEEEEEM--LLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNL 670
Query: 2432 HIKDNKNDFSPKVE---LATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDE 2488
I P+++ I+ K + V+ + S+ +E+ SKS +
Sbjct: 671 SIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSES-DGEASKSTNS 729
Query: 2489 RKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAE 2548
+ T+ K P P+S + +P +TP + E
Sbjct: 730 ----VFGGLESMIKEARRTAEQASKPKVP-------PKSEKENDP------LRTPEALPE 772
Query: 2549 EK---YRQQKEEI-EKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSE 2604
EK YR KEEI ++KQ + +KT S + N +V + GI
Sbjct: 773 EKKIEYRLLKEEIANREKQRLIKSDQLKTSSSS-------------PANSDVEIDGIGRI 819
Query: 2605 CTVVQPSPGSQSNA---RILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQ 2661
V + ++S RIL + ++ L + AK+ V A E K E LQ
Sbjct: 820 AMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQ--EAKKKESVRNA-EAKITKLTEQLQ 876
Query: 2662 SSRDIMQ------SKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKL 2715
++ I+ K +I + Q + ++ KY E+L ++ K K +
Sbjct: 877 ATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQD 936
Query: 2716 PTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLA----ERHY 2771
+ + D S S ++ ++ K++ K + A K++ A E+
Sbjct: 937 RFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQN 996
Query: 2772 QLPKKEKRVTVQLPTESIQKNQEDKLKM 2799
P E+ LP S+ +DKL +
Sbjct: 997 ISPVVEEEPEFSLPQPSLHDLTQDKLTL 1024
>gi|146134388 YLP motif containing 1 [Homo sapiens]
Length = 2146
Score = 56.2 bits (134), Expect = 6e-07
Identities = 89/408 (21%), Positives = 147/408 (36%), Gaps = 72/408 (17%)
Query: 2259 TSTGLKMAMERSLNPINFNPENNVKESECPL-----PPPSPPPPP--PSNASSEIEFPLP 2311
+S+G E+ L + + + K+ +C L PPP PPPP P + + P
Sbjct: 46 SSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQ---P 102
Query: 2312 PPPPLMMFPEKNGFLPSLSTEK--------IKAEFESFPGL-------PLPPPPVDEKSE 2356
PPPP+ P G P+LS +K + + + PGL P PPV S
Sbjct: 103 PPPPM---PPPPG--PALSYQKQQQYKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSY 157
Query: 2357 RESSSMFLPPPPP------------------PTPSQK----------PAHLLSSSAPEKH 2388
S ++PPP P P+PSQ P++ SSS+ + +
Sbjct: 158 MPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSY 217
Query: 2389 SGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELAT 2448
+AS S+ SQ K+ +L PP P NK + L +
Sbjct: 218 LSHSQSYLPSSQASPSRPSQGH---SKSQLLAPPP------PSAPPGNKTTVQQE-PLES 267
Query: 2449 SLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTS 2508
+ + + + MT E + SL +R ++ + T
Sbjct: 268 GAKNKSTEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDTP 327
Query: 2509 APRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYY 2568
P K+++ S S ++ P P + P + EE + EE + KQ +
Sbjct: 328 EPVKEEVTVPATSQVPESPSSEEPPLPPPNEEVPPPLPPEEPQSEDPEEDARLKQLQA-- 385
Query: 2569 NIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQS 2616
Q QH + + +QK + + + ++QP P Q+
Sbjct: 386 AAAHWQQHQQHRVGFQYQGIMQKHTQLQQI--LQQYQQIIQPPPHIQT 431
Score = 47.4 bits (111), Expect = 3e-04
Identities = 46/165 (27%), Positives = 66/165 (40%), Gaps = 46/165 (27%)
Query: 2280 NNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKN-------------GFL 2326
++V + P+P P PPPPP PLPPPPP++ P+ + G
Sbjct: 1535 SSVPVTRPPVPIPPPPPPP----------PLPPPPPVIK-PQTSAVEQERWDEDSFYGLW 1583
Query: 2327 PSLSTEKIKAEFES----FPGLP-LPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLS 2381
+ + + +EF+S P P LPPPPV PPP P P P +S
Sbjct: 1584 DTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSI----------PPPGPVPMGMPP--MS 1631
Query: 2382 SSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPK 2426
P + + D+ S N +I G+ L P LP+
Sbjct: 1632 KPPPVQQTVDY-----GHGRDISTNKVEQIPYGERITLRPDPLPE 1671
Score = 41.6 bits (96), Expect = 0.014
Identities = 34/144 (23%), Positives = 51/144 (35%), Gaps = 33/144 (22%)
Query: 2290 PPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPP 2349
PPP PPP P+ PP ++ P S+ + P +P+PPP
Sbjct: 1507 PPPGSYRPPP---------PMGKPPGSIVRPSAPPARSSVPVTR--------PPVPIPPP 1549
Query: 2350 PVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQA 2409
P PPPP P P +SA E+ D Y + ++ Q +
Sbjct: 1550 P----------------PPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNS 1593
Query: 2410 KIITGKTGVLPPPTLPKPKLPKHI 2433
+ + + P LP P + I
Sbjct: 1594 EFKSETAAIPSAPVLPPPPVHSSI 1617
Score = 41.2 bits (95), Expect = 0.018
Identities = 84/389 (21%), Positives = 139/389 (35%), Gaps = 66/389 (16%)
Query: 2289 LPPPS------PPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFP 2342
LPPPS PP PP + SS P+ P PPL G P + I + + P
Sbjct: 591 LPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPGVPQGIPPQLTAAP 650
Query: 2343 GLPLPPPPVDEKSERESSSMFLPP------PP----PPTPSQKPAHLLSSSAPEKHSGDF 2392
P + E+ ++ P PP PP S P+ ++S AP S
Sbjct: 651 VPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALP 710
Query: 2393 MQQYSQKEA---SNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATS 2449
+S + S++ SQ V LP P +++ + P+ +
Sbjct: 711 YSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYLESPR---GPRFDGPRR 767
Query: 2450 LSDMECKITTSKDQ------------KKVMVMTSSEHTETKQNVISKSLDERKQLSIDSA 2497
D+ + + + + +E T++K +I + Q I +
Sbjct: 768 FEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRG--PASQFYITPS 825
Query: 2498 NCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEE 2557
LS P S P+ K P + Q P + K PL A+ QQK
Sbjct: 826 TSLS---PRQSGPQWKGPKPAFGQQHQQQPKSQAEP---LSGNKEPL--ADTSSNQQK-- 875
Query: 2558 IEKQKQESSYYNI------VKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPS 2611
K +S+ ++I VK N+++++ ++E P + +E V+PS
Sbjct: 876 --NFKMQSAAFSIAADVKDVKAAQSNENLSDSQQEPPKSEVSE-----------GPVEPS 922
Query: 2612 PGSQSNARILGVCSDNQLSTTSPETVAAK 2640
Q N + + D + T P +A K
Sbjct: 923 NWDQ-NVQSMETQIDKAQAVTQPVPLANK 950
Score = 39.7 bits (91), Expect = 0.054
Identities = 34/113 (30%), Positives = 43/113 (38%), Gaps = 17/113 (15%)
Query: 2290 PPPSPPPPP-------PSNASSEIEFPLPPPPP-LMMFPEKN----GFLPSLSTEKIKAE 2337
PPP PPPPP P S P P M F E++ L + ++++
Sbjct: 16 PPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCV 75
Query: 2338 FE--SFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKH 2388
+ P PLPPPPV + PPPPP P PA KH
Sbjct: 76 LQPHHLPPPPLPPPPV---MPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKH 125
Score = 38.9 bits (89), Expect = 0.092
Identities = 56/215 (26%), Positives = 80/215 (37%), Gaps = 51/215 (23%)
Query: 2224 EMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVK 2283
+++ EK T++ K ++ + K F N G M+M P + P +
Sbjct: 474 QLQEYEKQWKTWQGHMKATQSYLQEKVNSFQNMKNQYMG-NMSMPPPFVPYSQMPPP-LP 531
Query: 2284 ESECPLPPPSPPPP--PPSNASSEIEFPLPP---PPPLMMFPEKNGFLPSLSTEKIKAEF 2338
P+ PPS PPP PP+ ++ +PP PP L G PSLS+
Sbjct: 532 TMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSS------- 584
Query: 2339 ESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQ 2398
+ P LPPP S S PPP P PS LSS+AP
Sbjct: 585 -AGPPPVLPPP---------SLSSAGPPPVLPPPS------LSSTAP------------- 615
Query: 2399 KEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHI 2433
+ + PPP +P P +P+ I
Sbjct: 616 --------PPVMPLPPLSSATPPPGIPPPGVPQGI 642
Score = 32.3 bits (72), Expect = 8.6
Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 11/173 (6%)
Query: 3076 KEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTEN 3135
K++ +HQ+ H V E + +PP S PPS +++
Sbjct: 119 KQQQYKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYM--PPSQSYMPPPQPPPSYYP 176
Query: 3136 PTKNEL---------SQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLK 3186
PT ++ SQSP SY+ P P S S + S S S R
Sbjct: 177 PTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPS 236
Query: 3187 DTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTIT 3239
+K A P P+A P + E + S A + + + P T+T
Sbjct: 237 QGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMT 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 139,052,194
Number of Sequences: 37866
Number of extensions: 7004932
Number of successful extensions: 53858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 1260
Number of HSP's that attempted gapping in prelim test: 32545
Number of HSP's gapped (non-prelim): 13848
length of query: 3549
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3427
effective length of database: 13,627,866
effective search space: 46702696782
effective search space used: 46702696782
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.