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Search of human proteins with 119220598
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
(1088 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119220598 apolipoprotein B48 receptor [Homo sapiens] 2175 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 114 4e-25
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 105 2e-22
gi|38176300 nestin [Homo sapiens] 89 3e-17
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 76 2e-13
gi|150378549 tangerin [Homo sapiens] 73 1e-12
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 71 5e-12
gi|222537747 hypothetical protein LOC342979 [Homo sapiens] 69 2e-11
gi|60097902 filaggrin [Homo sapiens] 67 7e-11
gi|83921609 hypothetical protein LOC127254 [Homo sapiens] 67 9e-11
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens] 65 3e-10
gi|57864582 hornerin [Homo sapiens] 64 1e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 64 1e-09
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 64 1e-09
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 64 1e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 64 1e-09
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 63 1e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 63 2e-09
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 61 7e-09
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 61 7e-09
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 58 4e-08
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 58 4e-08
gi|7706635 cornulin [Homo sapiens] 57 7e-08
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 57 1e-07
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 57 1e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 56 2e-07
gi|4502805 chromogranin A precursor [Homo sapiens] 55 5e-07
gi|38372935 brevican isoform 1 [Homo sapiens] 54 6e-07
gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens] 54 6e-07
gi|157674363 protein phosphatase 1, regulatory subunit 15A [Homo... 54 8e-07
>gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
Length = 1088
Score = 2175 bits (5637), Expect = 0.0
Identities = 1088/1088 (100%), Positives = 1088/1088 (100%)
Query: 1 MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVE 60
MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVE
Sbjct: 1 MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVE 60
Query: 61 EEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGA 120
EEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGA
Sbjct: 61 EEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGA 120
Query: 121 GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEE 180
GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEE
Sbjct: 121 GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEE 180
Query: 181 EEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPG 240
EEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPG
Sbjct: 181 EEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPG 240
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE
Sbjct: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG
Sbjct: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ
Sbjct: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV
Sbjct: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
Query: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV
Sbjct: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
Query: 541 EWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHA 600
EWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHA
Sbjct: 541 EWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHA 600
Query: 601 GSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESE 660
GSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESE
Sbjct: 601 GSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESE 660
Query: 661 LSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEE 720
LSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEE
Sbjct: 661 LSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEE 720
Query: 721 AEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQG 780
AEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQG
Sbjct: 721 AEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQG 780
Query: 781 WDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGA 840
WDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGA
Sbjct: 781 WDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGA 840
Query: 841 EDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHP 900
EDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHP
Sbjct: 841 EDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHP 900
Query: 901 EGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
EGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA
Sbjct: 901 EGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
Query: 961 EAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEP 1020
EAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEP
Sbjct: 961 EAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEP 1020
Query: 1021 PAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQA 1080
PAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQA
Sbjct: 1021 PAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQA 1080
Query: 1081 RLGRPKPQ 1088
RLGRPKPQ
Sbjct: 1081 RLGRPKPQ 1088
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 114 bits (286), Expect = 4e-25
Identities = 145/518 (27%), Positives = 196/518 (37%), Gaps = 63/518 (12%)
Query: 38 EREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAV 97
E+E +A EE V G+ K E +DL + +EG + G +D G
Sbjct: 603 EQEVEANEENVKVHGGRKEKT--EILSDDLTD-KAEVSEGKAKSVGEAEDGPEGRGDGTC 659
Query: 98 EQTWGWGDGSSHGSQAERQ----DSGAGETAKAARCQEPSAHLEARKK--------SKAG 145
E+ G+ H ER+ D G GE + ++ A E KK +
Sbjct: 660 EEG---SSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKERE 716
Query: 146 SGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGE 205
G ++R+ + +E E E EE R E+E+E E E G + +
Sbjct: 717 QGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERK 776
Query: 206 TEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAG----KGEEVV--VVEKACES 259
E +AG + E+G E D GE EE EG G +G EV VE+
Sbjct: 777 KEERAG-----------KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE 825
Query: 260 TRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASG-GEE 318
G G E E G E G EE EE G EE E G GEE
Sbjct: 826 REEEEEEGEGEEEE-----GEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE 880
Query: 319 AETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVR 378
E GEE G G EE G G E G G EE G G +E G+ E + G
Sbjct: 881 EEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE-EGEG 939
Query: 379 QTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGR 438
+ E G GE E G+ EEEG+ E E E ++ + G E E + G
Sbjct: 940 EGEDGEGEGE---EEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE-----EGEGEGE 991
Query: 439 EAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAE----EAQEERGSSRD 494
E G +E E EG+ + G+ G + +E V+ E E +EE G
Sbjct: 992 EEEGEEEGEEEGEGEEEGEGE--------GEEEEEGEVEGEVEGEEGEGEGEEEEGEEEG 1043
Query: 495 PVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQ 532
E +GE E + E E + + TGEE Q
Sbjct: 1044 EEREKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQ 1080
Score = 112 bits (279), Expect = 2e-24
Identities = 126/444 (28%), Positives = 173/444 (38%), Gaps = 68/444 (15%)
Query: 62 EAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSH-------GSQAE 114
E +D E +G +++G G + PG+ + A ++ W DG G Q E
Sbjct: 667 EHWQDEEREKGEKDKGRGEMERPGEGEKE----LAEKEEWKKRDGEEQEQKEREQGHQKE 722
Query: 115 R---------QDSGAGETAKAARCQEPSAH-----------LEARKKSKAGSGACQDRSG 154
R ++ G GE + R +E +E ++ + G ++R+G
Sbjct: 723 RNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG 782
Query: 155 QAQERQESHEQEVNREERLRS-WEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAV 213
+ ++ +E +Q EE E++EE EV E +G E GE E + G
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE- 841
Query: 214 GPKAAGDNREME---QGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTW--GP 268
G + G+ E E +G E + GE EE G EG G+GEE + E G G
Sbjct: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 901
Query: 269 GAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEA 328
G E+ G EE G EE GEE GEE E GE+ E G EE
Sbjct: 902 GEGEEEGEGEGEEEEGEGKGEEE------GEEGE--GEGEEEEGEGEGEDGE-GEGEEEE 952
Query: 329 GTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGE 388
G G EE G G E G G E G G +E G+EE E G GE
Sbjct: 953 GEWEGEEEEGEGEGEEEGEGEG--EEGEGEGEEEEGEGEGEEEEG------EEEGEEEGE 1004
Query: 389 RLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEA------AESQTAGREAVG 442
E G EG+EE E EV + + G EE E + G E
Sbjct: 1005 GEEEGEG-------EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRR 1057
Query: 443 GQEAGESFEGQVDLRGKEAEMRQD 466
+E E EG+ G+E RQD
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQD 1081
Score = 105 bits (261), Expect = 3e-22
Identities = 155/623 (24%), Positives = 216/623 (34%), Gaps = 147/623 (23%)
Query: 288 GREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGT 347
G E+++ +G E + + EE GG + +T ++ + E S GEA
Sbjct: 592 GAEDSKG--NGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAED 649
Query: 348 ASGGEEAGTA---SGGDEAWTTSGKEEADLLGVRQTEYGAV--PGERLLEATGKVWVLEE 402
G GT S G E W +E+ G + G + PGE E K +
Sbjct: 650 GPEGRGDGTCEEGSSGAEHWQDEEREK----GEKDKGRGEMERPGEGEKELAEKEEWKKR 705
Query: 403 EGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAE 462
+G+E+ + E ++ + E E E G E G +E E EG+ G+ E
Sbjct: 706 DGEEQEQKEREQGHQKER--NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEE 763
Query: 463 MRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEE 522
+ + + EE EE EE G +GE E T E R EE+
Sbjct: 764 VEGEREKEEGERKKEERAGKEEKGEEEGDQ--------GEGEEEET-------EGRGEEK 808
Query: 523 LTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVL 582
G E E + V +G+G ++ EE E GE E
Sbjct: 809 EEGGEVEGGE----------------VEEGKG-----------EREEEEEEGEGE----- 836
Query: 583 ALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGE-QREEE 641
+EE E E G + E E E + ++ E G +E+ +GE + EEE
Sbjct: 837 ---EEEGEGEEEEG-------EGEEEEG-----EGKGEEEGEEGEGEEEGEEGEGEGEEE 881
Query: 642 ETAGGQTLAAEAEGDRESELSEVPEAG-GEGLTTQDAGCGTEEGEASVSENQELDGSTGA 700
E G E EG+ E E E G GEG + G G EEGE E +E +G
Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
Query: 701 DAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDV 760
+ G E E E+EE E +
Sbjct: 942 EDGEGEGEEEEGEWEGEEEEGEGEGEEE-------------------------------- 969
Query: 761 VPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAF 820
G GE E G+G +E+ E E G +E EG EEE G G
Sbjct: 970 -------GEGEGEE---GEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG------ 1013
Query: 821 ESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAV 880
E E G G VE EE G G + G + E+E
Sbjct: 1014 EEEEEGEVEGEVEGEEGEGE----GEEEEGEEEGEER------------------EKEGE 1051
Query: 881 GWQEREQREDSEGRCGDYHPEGE 903
G + R RE+ E G Y GE
Sbjct: 1052 GEENRRNREEEEEEEGKYQETGE 1074
Score = 102 bits (255), Expect = 2e-21
Identities = 150/616 (24%), Positives = 215/616 (34%), Gaps = 129/616 (20%)
Query: 351 GEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREA 410
G E +G +E + +E + G R+ + + + T K V E + EA
Sbjct: 592 GAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDD----LTDKAEVSEGKAKSVGEA 647
Query: 411 EVSPFPK-----QPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQ 465
E P + + G E ++ E + G + G E EG+ +L KE ++
Sbjct: 648 EDGPEGRGDGTCEEGSSGAEHWQD--EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKR 705
Query: 466 DLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTG 525
D + E+ + E+G ++ E+ GE E E + EEE G
Sbjct: 706 DGE------------EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEG 753
Query: 526 EESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALS 585
E E +G+G E+ G E+E GE +
Sbjct: 754 EGKE---------------------EGEGEEVEG--------EREKEEGERK-------- 776
Query: 586 KEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAG 645
KEE+ E G + E E E ++E G +E GE+ EEEE
Sbjct: 777 KEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE--GKGEREEEEEEGE 834
Query: 646 GQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPC 705
G+ E EG+ E E E G+G + G G EEGE E +E +G G
Sbjct: 835 GEE--EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE-----GEG 887
Query: 706 PSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHIS 765
GE E E E + G + G + E+ +
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE------------------ 929
Query: 766 AAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREG 825
G GE EG G+G D + + E GE G +E G EG EEE G G + E EG
Sbjct: 930 --GEGEEEEGE-GEGEDGEGEGEEEEGEWEGEEEEG-EGEGEEEGEGEGEEGEG----EG 981
Query: 826 GPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQER 885
G E EE G E+ EG G EEE G E
Sbjct: 982 EEEEGEGEGEEEEGEEEG-----------EEEGEG---------------EEEGEGEGEE 1015
Query: 886 EQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQA 945
E+ + EG EGE G G E +E E E E+ R +EE+ +
Sbjct: 1016 EEEGEVEGEVEGEEGEGE--------GEEEEGEEEGEEREKEGEGEENRRNREEEEEEEG 1067
Query: 946 PAEAAPESVGEAETAE 961
+ E E + E
Sbjct: 1068 KYQETGEEENERQDGE 1083
Score = 67.8 bits (164), Expect = 5e-11
Identities = 137/571 (23%), Positives = 202/571 (35%), Gaps = 86/571 (15%)
Query: 416 PKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMR-QDLGIRADRA 474
P++P L E T+EA ++ E++G + + L E ++ + + +
Sbjct: 468 PEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQ 527
Query: 475 RMEELVQAEEAQEERGSSRDPVAELPSDGEA---EGTADLEATPEARPEEELTGEESEAA 531
+ EL Q E S +G+A + + T A E + EE E
Sbjct: 528 TIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIP 587
Query: 532 QTSCGLLGVEWGGLTHSVTKG--QGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQ 589
+ G + G+ + + ++ GG + T+ + + E+ A S E
Sbjct: 588 EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA 647
Query: 590 ERSLEAGPRHAGSVKPEASEAFPGAWENRTR----KDMERGNTQEDAAD----GEQREEE 641
E GP G E + W++ R KD RG + E+ E +
Sbjct: 648 ED----GPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWK 703
Query: 642 ETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGAD 701
+ G + E E + E ++ E GGE ++ G G EE E E +E +G G +
Sbjct: 704 KRDGEEQEQKEREQGHQKERNQEMEEGGE----EEHGEGEEE-EGDREEEEEKEGE-GKE 757
Query: 702 AGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVV 761
G E EE E +R G R +++ + G G GD
Sbjct: 758 EG-------------EGEEVEGEREKEEGER----------KKEERAGKEEKGEEEGD-- 792
Query: 762 PHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGG----QEFGLEGSAEEEVTGRGSQV 817
G GE E G+G + +E E GE G +E EG EEE G G +
Sbjct: 793 -----QGEGEE-EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE-EGEGEEE 845
Query: 818 EAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEE 877
E E G G E EE G E+ EG G E G E
Sbjct: 846 EGEGEEEEGEGKGEEEGEEGEGEEEG----------EEGEGEGEEEEGEG--------EG 887
Query: 878 EAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQ 937
E G E E+ E+ EG G+ EGE + EG G E +E E E E
Sbjct: 888 EEEGEGEGEE-EEGEGE-GEEEGEGEGE---EEEG---EGKGEEEGEEGEGEGEEEEGEG 939
Query: 938 EEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
E + E E GE E E G G
Sbjct: 940 EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
Score = 55.1 bits (131), Expect = 4e-07
Identities = 61/234 (26%), Positives = 89/234 (38%), Gaps = 35/234 (14%)
Query: 31 GDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRH 90
G+ E E + EE G E E +E+ EG G + EG G+ G++
Sbjct: 883 GEGEGEEEGEGEGEEEEG-----------EGEGEEEGEG-EGEEEEGEGKGEEEGEE--- 927
Query: 91 EVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQ 150
G E+ G G+G + E ++ GE E E + + G G +
Sbjct: 928 --GEGEGEEEEGEGEGEDGEGEGEEEE---GEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
Query: 151 DRSGQAQ----ERQESHEQEVNREERLRSWEQEEEEEEVRAR---EPGMARGAESEWTWH 203
+ G+ + E +E E+E EE +EEEE EV E G G E E
Sbjct: 983 EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE 1042
Query: 204 GETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGK--GEEVVVVEK 255
GE K G G+ + E + G+ +E G E + GEE V K
Sbjct: 1043 GEEREKEG------EGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSK 1090
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 105 bits (263), Expect = 2e-22
Identities = 199/815 (24%), Positives = 286/815 (35%), Gaps = 124/815 (15%)
Query: 62 EAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQT-WGWGDGSSHGSQAERQDSGA 120
+ Q+ L+ RG +G PG + V+ G G G S G + + G
Sbjct: 1688 DLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGE 1747
Query: 121 GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQ-ESHEQEVNREERLRSWEQE 179
G S L K K G + AQER+ ++H E + L EQE
Sbjct: 1748 G-----------SQRLNRDKDPKLGEA---EGDAMAQEREGKTHNSETSAGSELGEAEQE 1793
Query: 180 EEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGE-TEE 238
E R G G E +G+A A G + G ++D E E
Sbjct: 1794 GEGISERGETGGQGSGHEDN------LQGEAAAGGDQDPG----------QSDGAEGIEA 1837
Query: 239 PGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDG 298
P AEG + E E A PE G E P E+ A
Sbjct: 1838 PEAEGEAQPES--------EGVEA---------PEAEGDAQEAEGEAQPESEDVEAPEAE 1880
Query: 299 EEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTAS 358
EA+ S E+ ET E + S G EA A +EA +
Sbjct: 1881 GEAQPES--EDVETPEAEWEVQPESEGAEAPEAE-------------------KEAQPET 1919
Query: 359 GGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQ 418
EA T G++E + G E E EA G+ E E E +EAE P+
Sbjct: 1920 ESVEALETEGEDEPESEGAEAQE----AEEAAQEAEGQTQP-ESEVIESQEAEEEAQPES 1974
Query: 419 PQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEE 478
V E E E+Q A EA E E+ E + +++ E E + + +D +
Sbjct: 1975 EDV---EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE----SDGVEAQP 2027
Query: 479 LVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPE-EELTGEESEAAQTSCGL 537
+ EEAQE G ++ ++G+A+ +D PEA E +E GE EA G
Sbjct: 2028 KSEGEEAQEVEGETQK------TEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE----GE 2077
Query: 538 LGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGP 597
E + +G+ G + P + E ++A +E ++ E E +EA P
Sbjct: 2078 AHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEA-P 2135
Query: 598 RHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDR 657
G +PE+ E + + E QE E+ + E G + AE E
Sbjct: 2136 EAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE----AEEEAQPELEGVEAPEAEGEAQP 2191
Query: 658 ESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYAR--- 714
ESE E PEA GE + G E EA E +G +A GEA
Sbjct: 2192 ESEGIEAPEAEGEAQPELE---GVEAPEAEEEAQPEPEGVETPEAE-----GEAQPESEG 2243
Query: 715 ETEDEEAEADRTS-RRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHI---SAAGAG 770
ET+ E+ + + S G +A P ED T + GGD PH S G
Sbjct: 2244 ETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP---GGD-TPHQRPGSQTGPS 2299
Query: 771 EALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
+ G W + + G+ E R + +E P G
Sbjct: 2300 SSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGS 2359
Query: 831 RVEAEESAGAEDSCGLDPAGS-----QTARAEGMG 860
R + ++ D GS RA+G G
Sbjct: 2360 RTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFG 2394
Score = 92.4 bits (228), Expect = 2e-18
Identities = 152/595 (25%), Positives = 214/595 (35%), Gaps = 76/595 (12%)
Query: 483 EEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEW 542
+E ++ GS R + P GEAEG A + E + T SE + G+
Sbjct: 1741 DEGEDGEGSQRLNRDKDPKLGEAEGDA-MAQEREGKTHNSETSAGSELGEAEQEGEGISE 1799
Query: 543 GGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGS 602
G T G L G A Q + G A E E EA P G
Sbjct: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDG--------AEGIEAPEAEGEAQPESEGV 1851
Query: 603 VKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELS 662
EA EA A E E + + A+GE + E E +T AE E ESE +
Sbjct: 1852 ---EAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDV--ETPEAEWEVQPESEGA 1906
Query: 663 EVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAE 722
E PEA ++A TE EA +E ++ S GA+A + +T+ E
Sbjct: 1907 EAPEA------EKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEV 1960
Query: 723 ADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMG--GDVVPHISAAGAGEALEGVLGQ- 779
+ +A P+ ED + V G+ P A EA EG + +
Sbjct: 1961 IESQ-------EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEA-EGEMQEA 2012
Query: 780 ---------GWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
G +++ K E + G+ EG A+ E G + E++E
Sbjct: 2013 EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ 2072
Query: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQRED 890
E E +ED + G +EG+ A EA G +K +E E E + +
Sbjct: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAP-EAEGEAQKAEGIEAPET---EGEAQPE 2128
Query: 891 SEG-----RCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQA 945
SEG G+ PE E DAEG EA+E E E+ + G E +A
Sbjct: 2129 SEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVE---APEA 2185
Query: 946 PAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSR 1005
EA PES G E EA G A + L G V + + +
Sbjct: 2186 EGEAQPESEG-IEAPEAEGEA---------QPELEG-----------VEAPEAEEEAQPE 2224
Query: 1006 PSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPL---QLEEPLEPSPLRHDGTPVP 1057
P TP E + +P + + E Q L Q EE E S + P P
Sbjct: 2225 PEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP 2279
Score = 90.9 bits (224), Expect = 6e-18
Identities = 209/883 (23%), Positives = 314/883 (35%), Gaps = 118/883 (13%)
Query: 148 ACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETE 207
AC +A+ E N E+ + QEE + E +E G + E ET+
Sbjct: 1268 ACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGEGLQEEAVQLEETK 1326
Query: 208 GKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWG 267
+ G E+GV+ + ETE G G+ EE +E+ E T G
Sbjct: 1327 TEEGL-----------QEEGVQLEETKETE-----GEGQQEEEAQLEEIEE------TGG 1364
Query: 268 PGAEPEDWGILGREEARTTPGREEARAILDG------EEARTISGGEEAETASG---GEE 318
G + E G+ E G + A+ +G E ++ G E +E +S G +
Sbjct: 1365 EGLQEE--GVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQ 1422
Query: 319 AETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVR 378
+ EEAG AS E A G E T + T E + S E G+
Sbjct: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEP----GLE 1478
Query: 379 QTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGR 438
+ + G+ +A E A + P VL ++TE+A + A
Sbjct: 1479 KPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVL-LKKTEKAFLAHLAS- 1536
Query: 439 EAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAE 498
AV A + L AE++QD+ R + EL Q+ +G + V E
Sbjct: 1537 -AVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKREL------QKLQGRAGRMVLE 1589
Query: 499 LPSDG--------------EAEGTADLEATPEAR---PEEELTGEESEAAQTSCGL-LGV 540
P + G +L A E T E+ A T+ G LG
Sbjct: 1590 PPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGE 1649
Query: 541 EWGG---------LTHSVTKGQGPELMGGAQTPTK------QPEEREAGEV---ELMGVL 582
E G + V+ MG + P K Q +R+ GE E V
Sbjct: 1650 EAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVA 1709
Query: 583 ALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGE------ 636
S G + P S+ PG E + +R N +D GE
Sbjct: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQG-PGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM 1768
Query: 637 -QREEEETAGGQTLAAEAEGDRESE---LSEVPEAGGEGLTTQDAGCGTEEGEASVSENQ 692
Q E +T +T A G+ E E +SE E GG+G +D +GEA+ +Q
Sbjct: 1769 AQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHED----NLQGEAAAGGDQ 1824
Query: 693 ELDGSTGADAGPCPSL-GEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSV 751
+ S GA+ P GEA E EA+ ++ +A P+ ED +
Sbjct: 1825 DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQ-----EAEGEAQPESEDVEAPEA 1879
Query: 752 AAGIMGGDVVPHISAAGAGEALEGVL--GQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEE 809
G+ P EA V +G ++ E E+ A E + EG E E
Sbjct: 1880 E-----GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPE 1934
Query: 810 VTGRGSQVEAFESREGGPWGGRVEAE--ESAGAEDSCGLDPAGSQTARAEGMGAMVEAGG 867
G +Q EA E+ + + E+E ES AE+ + + E E
Sbjct: 1935 SEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
Query: 868 LLEKWTLLEEEAVGWQ---EREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
E + EA G E E + +S+G EGE + ++ E G + E+
Sbjct: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESD 2053
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSAR 967
E E + E +A EA PES + + EA G A+
Sbjct: 2054 GVEAPEAEEEAQEAEGEVQEAEGEAHPES-EDVDAQEAEGEAQ 2095
Score = 50.4 bits (119), Expect = 9e-06
Identities = 62/224 (27%), Positives = 88/224 (39%), Gaps = 33/224 (14%)
Query: 31 GDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRH 90
G P E EAQ AE A G+ E+ ++ EG ++EG G+ ++
Sbjct: 2054 GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKA 2113
Query: 91 EVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQ 150
E G A E T G S G +A P A EA+ +S+ Q
Sbjct: 2114 E-GIEAPE-TEGEAQPESEGIEA------------------PEAEGEAQPESEGVE--AQ 2151
Query: 151 DRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKA 210
D G+AQ E E + E E + E E V A E ESE E EG+A
Sbjct: 2152 DAEGEAQPESEGIEAQEAEE------EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
Query: 211 -----GAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEE 249
G P+A + + +GV +A +P +EG +GE+
Sbjct: 2206 QPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEK 2249
Score = 41.2 bits (95), Expect = 0.005
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 23/249 (9%)
Query: 771 EALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
E EG G+G + + G QE G++ +E G G Q E + E GG
Sbjct: 1305 ETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGG 1364
Query: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQRED 890
EE E+ G Q G +E G L++ L EE +V QE +
Sbjct: 1365 EGLQEEGVQLEEVKEGPEGGLQ-------GEALEEG--LKEEGLPEEGSVHGQELSEASS 1415
Query: 891 SEGRCG---DYHPEGEAPRL------LDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQP 941
+G+ D E EA R AEG + ET+P + E G + +P
Sbjct: 1416 PDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEP 1475
Query: 942 THQAPAEAAPESVGEAETAEAMGSARGGAANSWSEA----PLPGSLLDVSVPRS-RVHLS 996
+ P A + G+A ++ + S A P+ S+L ++ HL+
Sbjct: 1476 GLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLA 1535
Query: 997 RSSSQRRSR 1005
+ ++ R+R
Sbjct: 1536 SAVAELRAR 1544
Score = 37.4 bits (85), Expect = 0.078
Identities = 54/234 (23%), Positives = 91/234 (38%), Gaps = 31/234 (13%)
Query: 31 GDAVPTVER-EAQAAE-ELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDR 88
G+A P E EAQ AE E + G + EEEAQ +LEG+ + EG + G +
Sbjct: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
Query: 89 RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
G + E G + + + + ET +A +P + E + + K GS
Sbjct: 2199 PEAEGEAQPELE---GVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK-GSPQ 2254
Query: 149 CQDRSGQAQERQES--------------------HEQEVNR----EERLRSWEQEEEEEE 184
GQ++E ES H++ ++ R SW +++
Sbjct: 2255 VSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDS 2314
Query: 185 VRAREPGMARGAESEWTWHGETEGKAGAVGPKAA-GDNREMEQGVREADAGETE 237
G R +++ T E KA + P+++ + E G R + G +E
Sbjct: 2315 ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASE 2368
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 88.6 bits (218), Expect = 3e-17
Identities = 181/742 (24%), Positives = 269/742 (36%), Gaps = 139/742 (18%)
Query: 154 GQAQERQESHE---QEVNREERLRSWEQEEEEEEVRARE--PGMARGAESEWTWHGETEG 208
G+ QE S E QE+ + ++ WE E+++ A+E PGMA G E+E
Sbjct: 926 GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMA-GVENEDEAELNLRE 984
Query: 209 KAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVV------VVEKACESTRA 262
+ G G E+ V + + TEE G G E +VE A A
Sbjct: 985 QDGFTGK---------EEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGA 1035
Query: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEA--ETASGGEEAE 320
G P + + G G + + P E +++ + A GG++A E G E A
Sbjct: 1036 EGLQDPEGQSQQVGAPGLQAPQGLP--EAIEPLVEDDVA---PGGDQASPEVMLGSEPAM 1090
Query: 321 TASGGEEAGTASGGEEAGIASGGEAGTASGGE--EAGTASGGDEAWTTSGKE----EADL 374
GE A A G G+ G+ G + E E EA G E + +
Sbjct: 1091 ----GESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEE 1146
Query: 375 LGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEV-----SPFPKQ----------- 418
G TE+ +PG+ + W EG EE EAE FP +
Sbjct: 1147 AGGLGTEFSELPGK-----SRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPS 1201
Query: 419 PQVLGTERTEEAA----------------ESQTAGREAVGGQEAGESFEGQVDLRGKEAE 462
P LG+E EE ++ +A G QEA +G+ + GK
Sbjct: 1202 PWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVES 1261
Query: 463 MRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEE 522
+++LG +E + EE++EE S D + E D G T P +
Sbjct: 1262 EQEELGSGEIPEGPQE--EGEESREE--SEEDELGETLPDSTPLGFYLRSPTS---PRWD 1314
Query: 523 LTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMG--GAQTPTKQPEEREAGEVELMG 580
TGE+ Q G +G P ++ G + P + EE E GE E
Sbjct: 1315 PTGEQRPPPQGETG-------------KEGWDPAVLASEGLEAPPSEKEEGEEGEEECGR 1361
Query: 581 VLALSKEEQERSLEAG--PRHAGSVKPEASEA-----FPGAWENRTRKDMERGNTQEDAA 633
LS+E ++ EA P G V + P AW+ +D E ++
Sbjct: 1362 DSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWD----RDGESDGFADEEE 1417
Query: 634 DGEQREEEETAGGQTLAAE-AEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQ 692
GE+ EE++ G + A G L + L++ G E SVS
Sbjct: 1418 SGEEGEEDQEEGREPGAGRWGPGSSVGSL--------QALSSSQRGEFLESDSVSVSVPW 1469
Query: 693 ELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVA 752
+ D GA AG A +T E D G ++ V L +RED G +
Sbjct: 1470 D-DSLRGAVAG---------APKTALETESQDSAEPSGSEEESDPVSL-EREDKVPGPL- 1517
Query: 753 AGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTG 812
++ + AG G + GV GQG + + K + G G E E +
Sbjct: 1518 ------EIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVS 1571
Query: 813 RGSQVEAFESREGG----PWGG 830
G + F+ EG W G
Sbjct: 1572 EGDRGSPFQEEEGSALKTSWAG 1593
Score = 60.8 bits (146), Expect = 7e-09
Identities = 166/717 (23%), Positives = 240/717 (33%), Gaps = 144/717 (20%)
Query: 60 EEEAQEDLEGLRGSQNEGAGRLR------GPGDDRRHEVGS-SAVEQTWGWGDGSSHGSQ 112
+E AQE G+ G +NE L G + E G +A E+ W G+G +
Sbjct: 959 QELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPE 1018
Query: 113 AERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQE-RQESHEQEVNREE 171
+ Q G E A K G+ QD GQ+Q+ + E
Sbjct: 1019 PKEQ-RGLVEGASV----------------KGGAEGLQDPEGQSQQVGAPGLQAPQGLPE 1061
Query: 172 RLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREA 231
+ +++ P + G+E A+G AAG QGV
Sbjct: 1062 AIEPLVEDDVAPGGDQASPEVMLGSEP-------------AMGESAAGAEPGPGQGV--- 1105
Query: 232 DAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGR-- 289
G +PG + E + E++ E+ R G GP + E+ G LG E + PG+
Sbjct: 1106 --GGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSEL-PGKSR 1162
Query: 290 ---EEARAILDGEEARTISGGEEAETAS---------------GGEEAET---------- 321
E R + EA G EEA A G EEAE
Sbjct: 1163 DPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPS 1222
Query: 322 ----------------ASGGEEA--GTASGGEEAGIASGGEAGTASGGEEAGTASGGDEA 363
A G +EA G E G + SG G G+E+
Sbjct: 1223 PTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEES 1282
Query: 364 WTTSGKEEADLLGVRQTEYGAVP-GERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVL 422
S E D LG +T + P G L T W E + E P VL
Sbjct: 1283 REES---EEDELG--ETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVL 1337
Query: 423 GTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQA 482
+E E + G E G +E G + +E +DLG A A
Sbjct: 1338 ASEGLEAPPSEKEEGEE--GEEECGRDSD--------LSEEFEDLGTEAPFLPGVPGEVA 1387
Query: 483 EEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEW 542
E + DP A DGE++G AD E + E E++ G E A + W
Sbjct: 1388 EPLGQVPQLLLDPAA-WDRDGESDGFADEEESGEEGEEDQEEGREPGAGR---------W 1437
Query: 543 G-----GLTHSVTKGQGPELMGGAQTPTKQP-EEREAGEVELMGVLALSKEEQERSLEAG 596
G G +++ Q E + P ++ G V AL E Q+ + +G
Sbjct: 1438 GPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSG 1497
Query: 597 -PRHAGSVKPEASEAFPGAWENRT-------RKDMERGNTQEDAADGEQRE--------- 639
+ V E + PG E + D+ N Q +G+ +
Sbjct: 1498 SEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGL 1557
Query: 640 EEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDG 696
E+ GQ + +EGDR S E G L T AG G+ + + +G
Sbjct: 1558 EQSEEVGQGMPLVSEGDRGSPFQ---EEEGSALKTSWAGAPVHLGQGQFLKFTQREG 1611
Score = 45.8 bits (107), Expect = 2e-04
Identities = 113/480 (23%), Positives = 164/480 (34%), Gaps = 98/480 (20%)
Query: 562 QTPTKQPEEREAGEVELMGVLALSKEEQE--RSLEAGPRHAGSVKPEASEAFP--GAWEN 617
Q P PEE G + L KE QE S+E ++ E E+ GAW
Sbjct: 846 QAPLWTPEEINQGAMN-----PLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAW-- 898
Query: 618 RTRKDMERGNTQEDAADGEQR--EEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQ 675
++E + E+ QR EEEE G +G+ + L + E G E +
Sbjct: 899 ----NLENLRSPEEVDKESQRNLEEEENLG--------KGEYQESLRSLEEEGQELPQSA 946
Query: 676 DAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQA 735
D + E +V ++QEL A P G E E E D
Sbjct: 947 DV----QRWEDTVEKDQEL-----AQESPPGMAGVENEDEAELNLREQD----------- 986
Query: 736 VAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGV----LGQGWDSKEKEEAAA 791
G +E+ V G + I G E+ E L +G K E
Sbjct: 987 ---GFTGKEEV----VEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQ 1039
Query: 792 GEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGS 851
Q+ G G + G +E + P G + E G+E + G AG+
Sbjct: 1040 DPEGQSQQVGAPGLQAPQ--GLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGA 1097
Query: 852 QTARAEGMGAMVEAGGLLEKWTL---LEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLL 908
+ +G+G + + G L + + LEEE++ E ++ + EG D L
Sbjct: 1098 EPGPGQGVGGLGDPGHLTREEVMEPPLEEESL---EAKRVQGLEGPRKD----------L 1144
Query: 909 DAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
+ G + T K +P G+EE AP EA AE +G
Sbjct: 1145 EEAGGLGTEFSELPGKSRDPWEPPR-EGREESEAE------APRGAEEAFPAETLGHTGS 1197
Query: 969 GAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEE 1028
A + W PL + VP V PS TP E+ P P P E
Sbjct: 1198 DAPSPW---PLGSEEAEEDVPPVLV-----------SPSPTYTPI---LEDAPGPQPQAE 1240
Score = 35.4 bits (80), Expect = 0.30
Identities = 28/80 (35%), Positives = 34/80 (42%), Gaps = 10/80 (12%)
Query: 816 QVEAFESREGGPWGGRVEA--------EESAG-AEDSCGLDPAGSQTARAEGMGAMVEAG 866
+VE R G W G V E S G A + G G++ R E E G
Sbjct: 174 EVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERG 233
Query: 867 GLLEKWTLLEEEAVG-WQER 885
GLLE+ LE+ G WQER
Sbjct: 234 GLLERRAALEQRLEGRWQER 253
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 75.9 bits (185), Expect = 2e-13
Identities = 157/680 (23%), Positives = 240/680 (35%), Gaps = 108/680 (15%)
Query: 373 DLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAE 432
D LG YGA+ G++L+ + +L+E P P L + + EA+
Sbjct: 244 DALGQDAAHYGALAGDKLI-----LHLLQEAAQR---------PSPPSALTEDDSGEASS 289
Query: 433 SQTA---GREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEER 489
+ G++ + + + + + +R +R R+ + ++ E +ER
Sbjct: 290 QNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKER 349
Query: 490 GSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSV 549
P A E + + E + E+E G E E+ Q+ LL E ++ V
Sbjct: 350 RQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDV 409
Query: 550 T-----KGQGPELMGGAQTPTKQ----PEEREAGEVELMGVLALSKE---EQERSLEAGP 597
T +G+ P+L G ++Q +E A E + VL + E+ + LE
Sbjct: 410 TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFE 469
Query: 598 RHAGSVKPEA-SEAFPGAWENRTRKDMERGNTQ-------------------EDAADGEQ 637
+ ++ EA +E P A + R + ++ Q E AA GE
Sbjct: 470 KDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGES 529
Query: 638 REEEETA---------------------GGQTLAAEAEGDR--ESELSEVPEAGGEGLTT 674
TA G +T+ EA GD E+ E G E
Sbjct: 530 EVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGA 589
Query: 675 QDAGCGTEEGEASVSENQELDGS-TGADAGPCPSLGEAYARETEDEEA---EADRTSRRG 730
+ G E + + +E +E++ + A+ P+ +A ET EA EA +T
Sbjct: 590 EATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEE 649
Query: 731 WRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAA 790
+QA VG E TG+ G + G GV G ++ E
Sbjct: 650 AEMQAYGVGAGQAEPPVTGTTNMEATG--------SRATGMESTGVSATGVENPGVEATV 701
Query: 791 AG------EHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSC 844
G H G E + E E RG + EA RE R A E A C
Sbjct: 702 PGISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQRE------REAAAELEAALGKC 754
Query: 845 GLDPAGSQTAR-----AEGMGAMVEAGG-LLEKWTLLEEEAVGWQEREQREDSEGRCGDY 898
A + R AEG GA GG + LE+ ++R+ R
Sbjct: 755 EAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASAC 814
Query: 899 HPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAE 958
E A RLL E G RAE + E LE R E A A A E +
Sbjct: 815 LDEARASRLLAEE---EARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ--QRT 869
Query: 959 TAEAMGSARGGAANSWSEAP 978
A +G AR A +E P
Sbjct: 870 AAAELGRARDAAEARVAELP 889
Score = 54.3 bits (129), Expect = 6e-07
Identities = 138/542 (25%), Positives = 186/542 (34%), Gaps = 90/542 (16%)
Query: 159 RQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARG--------AESEWTWHGETEGK- 209
R E + E L++ Q+E E RE G A G A H E G
Sbjct: 493 RAEFDQLRRQHAEALQALRQQETREV--PREEGAACGESEVAGATATKNGPTHMELNGSV 550
Query: 210 --------AGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAG--------KGEEV--- 250
A + +AAGD ME EA+A E GAE G G EV
Sbjct: 551 APETKVNGAETIDEEAAGDET-MEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREM 609
Query: 251 -VVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARA--ILDGEEARTISGG 307
E+A T+ G E +G E +T E +A + G+ ++G
Sbjct: 610 ETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGT 669
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTA--SGGEEAGTASGGDEAWT 365
E ++G G + G EA + G AG G EA +
Sbjct: 670 TNMEATGSRATGMESTGVSATGVENPGVEATV-PGISAGPILHPGAAEASEKLQVELETR 728
Query: 366 TSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTE 425
G EEA +RQ E A L A GK E E R E
Sbjct: 729 IRGLEEA----LRQREREA--AAELEAALGKCEAAEAEAGRLR----------------E 766
Query: 426 RTEEAAESQTAGREAVGGQEAGESFE-GQVDLRGKEAEMRQDLGIRA--DRARMEELVQA 482
R EA S +G + + E + DLR +++ +R+ A D AR L+
Sbjct: 767 RVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAE 826
Query: 483 EEAQEERGSSRDPVAELPSDGEA--EGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
EEA+ R AEL EA E + +LE E TGE+ A
Sbjct: 827 EEARGLR-------AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAEL----- 874
Query: 541 EWGGLTHSVTKGQGPELMGGAQTPTK-QPEEREAGEVELMGVLALSKEE--QERSLEAGP 597
G + + EL + + E REA E V+ S+ QE +LE
Sbjct: 875 ---GRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRG 931
Query: 598 RHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG-QTLAAEAEGD 656
R A S++ E G R R ++ER E E E G Q A+ EG
Sbjct: 932 R-AASLEQEV--VATGKEAARLRAELER----ERVCSVALSEHERIVGTLQANVAQLEGQ 984
Query: 657 RE 658
E
Sbjct: 985 LE 986
Score = 44.7 bits (104), Expect = 5e-04
Identities = 97/419 (23%), Positives = 138/419 (32%), Gaps = 49/419 (11%)
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTA--------------SGGEE 353
+ AE + ET E G A G E A+ + G +G E
Sbjct: 502 QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAET 561
Query: 354 AGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEA--TGKVWVLEEEGDEEREAE 411
+ GDE E A+ G T A G ++ E TG E +EE E
Sbjct: 562 IDEEAAGDETMEARTME-AEATGAEATGAEAT-GAKVTETKPTGAEVREMETTEEEANME 619
Query: 412 VSPFPKQP--------QVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLR--GKEA 461
P Q + +G E T+ AE VG +A G ++ G A
Sbjct: 620 TKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRA 679
Query: 462 EMRQDLGIRADRARMEELVQAEEAQEERGSSRDP-VAELPSDGEAEGTADLEATPEA-RP 519
+ G+ A V+A G P AE + E + EA R
Sbjct: 680 TGMESTGVSATGVENPG-VEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQ 738
Query: 520 EEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELM 579
E E EAA C E G L V + +G GG T Q L
Sbjct: 739 REREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQ----------LR 788
Query: 580 GVLALSKEE-QERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQR 638
L ++E+ ++R A S + + A E R + Q + A EQ
Sbjct: 789 AALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEAR-GLRAELAQREEARLEQS 847
Query: 639 EEEETAGGQTLAAEAEGDRE----SELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQE 693
E E Q A A G+++ +EL +A + A C EE ++E +E
Sbjct: 848 RELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC--EEARQGLAELRE 904
Score = 40.0 bits (92), Expect = 0.012
Identities = 123/547 (22%), Positives = 199/547 (36%), Gaps = 76/547 (13%)
Query: 40 EAQAAEELGVVAVG-KTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVE 98
+A E GV A+G + K EEA+ G+ GAG+ P G++ +E
Sbjct: 626 QATDTETTGVEAMGVEATKTKAEEAEMQAYGV------GAGQAEPP------VTGTTNME 673
Query: 99 QTWGWGDG-SSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQ 157
T G S G A ++ E P H A + S+ + R +
Sbjct: 674 ATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLE 733
Query: 158 E--RQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGP 215
E RQ E E L E E E A G+ + G+T A+
Sbjct: 734 EALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAAL-E 792
Query: 216 KAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDW 275
+A D R+ + +RE +A A + ++ E+ RA
Sbjct: 793 QAREDLRDRDSRLRELEAASACLDEARASR-----LLAEEEARGLRA------------- 834
Query: 276 GILGREEARTTPGREE-------ARAILDGEEARTISGG-EEAETASGGEEAETASGGEE 327
+ REEAR RE A A GE+ RT + A A+ AE + EE
Sbjct: 835 ELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEE 894
Query: 328 AGT-------ASGGEEAGIASGGE-----------AGTASGGEEAGTASGGDEAWTTSGK 369
A AS + E G A+ E+ A+G + A +
Sbjct: 895 ARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAEL 954
Query: 370 EEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEE 429
E + V +E+ + G LEE G + F Q + L +
Sbjct: 955 ERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERH 1014
Query: 430 AAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEER 489
AAE+Q A E Q G E + R ++A+ R + D+A+ E+ + E +E
Sbjct: 1015 AAEAQLATAEQ---QLRGLRTEAE---RARQAQSRAQEAL--DKAK-EKDKKITELSKEV 1065
Query: 490 GSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSV 549
+ ++ + E P+ A T ++EA + ++L + EAA+ ++ + L +++
Sbjct: 1066 FNLKEALKEQPA---ALATPEVEALRD--QVKDLQQQLQEAARDHSSVVALYRSHLLYAI 1120
Query: 550 TKGQGPE 556
+GQ E
Sbjct: 1121 -QGQMDE 1126
>gi|150378549 tangerin [Homo sapiens]
Length = 1523
Score = 73.2 bits (178), Expect = 1e-12
Identities = 225/983 (22%), Positives = 346/983 (35%), Gaps = 146/983 (14%)
Query: 54 KTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQA 113
K+ K+V+ E L G+ + DD + S + G+
Sbjct: 140 KSVKVVQAELSLTLSGVLLREGRAT-------DDDMQSLASLMSVKPSDVGNLDDFAESD 192
Query: 114 ERQDSGAGETAKAARCQEPSAHLEAR---KKSKAGSGACQDRSGQAQERQESHEQEVNRE 170
E + G G AR +P E + ++ + G G Q +++ V+
Sbjct: 193 EDEAHGPGAPEARARVPQPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAP 252
Query: 171 ERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGA-----VGPKAAGDNREME 225
+ + E RA E G G E+ E ++ P A R+
Sbjct: 253 APPARTSRGQGSE--RANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGS 310
Query: 226 QGVRE-ADAGETEEPGAEGA---GKGEEVVVVEKAC--ESTRAWGT-WGPGAEPEDWGIL 278
+R GE E P A GA G G +AC E T A G GP E + G
Sbjct: 311 DALRPPVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSG-- 368
Query: 279 GREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAG 338
GR+ +A E R + G + E SGG EA T G AG A EE+
Sbjct: 369 ------DPFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEA---EESS 419
Query: 339 IASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVW 398
+A S T G EA T EA G + G
Sbjct: 420 AVCQVDAEQRSKVRHVDTK--GPEA--TGVMPEARCRGTPEAPPRGSQGR---------- 465
Query: 399 VLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRG 458
L +E + +S P +P + + AG+E G + G G + G
Sbjct: 466 -LGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRG----GAPGIEG 520
Query: 459 KEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEAR 518
E +G + R ++ A + + SR + EA G+ DLE E
Sbjct: 521 TGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGG---WEAEAGGSGDLETETEVV 577
Query: 519 PEEELTGEESEAAQT---SCGLLGVE-WGGLTHSVTKGQ--GPELMGGAQTPTKQPEERE 572
E L +E E + L +E G L + + E+ G AQ + +E E
Sbjct: 578 GLEVLGTQEKEVEGSGFPETRTLEIEILGALEKEAARSRVLESEVAGTAQCEGLETQETE 637
Query: 573 AGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTR-KDMERGNTQED 631
G +E G E E G+ K EA + G + RT + E TQE
Sbjct: 638 VGVIETPGT------ETE--------VLGTQKTEAGGS--GVLQTRTTIAETEVLVTQEI 681
Query: 632 AADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEG----------LTTQDAGCGT 681
+ D + E+T + L + + E E S VPE+ EG +T +D+G
Sbjct: 682 SGDLGPLKIEDTIQSEMLGTQ---ETEVEASRVPESEAEGTEAKILGTQEITARDSGVRE 738
Query: 682 EEGEASVSE---NQELDG--------STGADAGPCPSLGEAYARETEDEEAEADRTSRRG 730
E E + S+ QE++ TGA G E +R++ EAD T
Sbjct: 739 IEAEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRDSGVPGLEADTTG--- 795
Query: 731 WRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAA 790
+Q VG + + TG+ I+G + A + G+ + ++E E
Sbjct: 796 --IQVKEVGGSEVPEIATGTAETEILGTQEI-----ASRSSGVPGLESEVAGAQETEVGG 848
Query: 791 AGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPA- 849
+G G E G+ A +T + + +E G EAE G+ A
Sbjct: 849 SG--ISGPEAGM-AEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVGSALKYEALRAP 905
Query: 850 -------GSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEG 902
GSQ A+AE G G + + E EA W SEG+ G + +
Sbjct: 906 VTQPRVLGSQEAKAEISGVQ---GSETQVLRVQEAEAGVWGM------SEGKSGAWGAQE 956
Query: 903 EAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEA 962
++L++ +A+E E L + +G+E A S+ EA+ A
Sbjct: 957 AEMKVLESP---ENKSGTFKAQEAEAGVLGNEKGKE------AEGSLTEASLPEAQVASG 1007
Query: 963 MGSARGGAAN---SWSEAPLPGS 982
G+ A++ + + LPGS
Sbjct: 1008 AGAGAPRASSPEKAEEDRRLPGS 1030
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 71.2 bits (173), Expect = 5e-12
Identities = 126/472 (26%), Positives = 173/472 (36%), Gaps = 68/472 (14%)
Query: 288 GREEARAILDGEEARTISGGEEAETASGGEEAETASGG----EEAGTASGGEEAGIASGG 343
G E A L + G EAE G E AE A G +EAG GG + G +
Sbjct: 16 GPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAG--GGGPDRGPEAEA 73
Query: 344 EAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEE 403
+ GE + A G EE G +Q E GA PG A G E
Sbjct: 74 RGTRGAHGETEAEEGAPEGAEVPQGGEETS--GAQQVE-GASPGR---GAQG-----EPR 122
Query: 404 GDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEM 463
G+ +RE E S P ER EEA + + G EAG+S VD G +
Sbjct: 123 GEAQREPEDSAAP--------ERQEEAEQRPEVPEGSASG-EAGDS----VDAEGPLGDN 169
Query: 464 RQDLGIRADRARMEELV-QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEE 522
+ G D E V + +A+ G S D L + +AEG A E R +
Sbjct: 170 IEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDS 229
Query: 523 LTGEESEAAQTSC-GLLG--VEWG-----GLTHSVTKGQGPELMG--GAQTPTKQP---E 569
+ E G +G VE G G+ V G E G G + P
Sbjct: 230 VDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRA 289
Query: 570 EREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPG--AWENRTRKDMERGN 627
R +GE + G +LS + + + AG E++ PG AW+ ++
Sbjct: 290 RRVSGEPQQSGDGSLSPQAEAIEVAAG---------ESAGRSPGELAWDAAEEAEVPGVK 340
Query: 628 TQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEE---- 683
E+AA G+ R + G+ + E E E EG ++A G EE
Sbjct: 341 GSEEAAPGDARAD----AGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDS 396
Query: 684 ---GEAS--VSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRG 730
GEAS +E + + A+ GP GEA E+ EA G
Sbjct: 397 SPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALG 448
Score = 58.2 bits (139), Expect = 4e-08
Identities = 119/461 (25%), Positives = 155/461 (33%), Gaps = 73/461 (15%)
Query: 551 KGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEAS-- 608
+G P G + P P GE G A E E + EA PR A +VK
Sbjct: 8 EGVAPGPQGPPEVPA--PLAERPGEPGAAGGEAEGPEGSEGAEEA-PRGAAAVKEAGGGG 64
Query: 609 -EAFPGAWENRTRKDMERGNTQEDAADGEQREE--EETAGGQTLAAEAEG---------- 655
+ P A TR +E A +G + + EET+G Q + + G
Sbjct: 65 PDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGE 124
Query: 656 -DRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYAR 714
RE E S PE E + G+ GEA S + E GP EA
Sbjct: 125 AQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAE---------GPLGDNIEAEGP 175
Query: 715 ETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALE 774
+ EAE R G + D E SV A GD + AG E
Sbjct: 176 AGDSVEAE----GRVGDSV--------DAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAE 223
Query: 775 GVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEA 834
G +G D+ E AG+ + G G + E G VEA G P G VEA
Sbjct: 224 GRVGDSVDA----EGPAGDSVDAE--GRVGDSVEAGDPAGDGVEA-----GVPAGDSVEA 272
Query: 835 EESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEA----------VGWQE 884
E AG DS + + R G G L + +E A + W
Sbjct: 273 EGPAG--DSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDA 330
Query: 885 REQRE------DSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPES--LEHVRG 936
E+ E E GD + R+ +G G E +E PE E G
Sbjct: 331 AEEAEVPGVKGSEEAAPGDARADAGEDRV--GDGPQQEPGEDEERRERSPEGPREEEAAG 388
Query: 937 QEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEA 977
EE+ +P A E E + A G A EA
Sbjct: 389 GEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEA 429
Score = 56.2 bits (134), Expect = 2e-07
Identities = 105/421 (24%), Positives = 162/421 (38%), Gaps = 45/421 (10%)
Query: 35 PTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGS 94
P ER + G A G G EEA ++ + G G RGP + R G+
Sbjct: 23 PLAERPGEPGAA-GGEAEGPEGSEGAEEAPRGAAAVK--EAGGGGPDRGPEAEARGTRGA 79
Query: 95 SAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSG 154
+ + Q + SGA + A+ + + + A +R
Sbjct: 80 HGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQE 139
Query: 155 QAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVG 214
+A++R E E + E G + AE + E EG A G
Sbjct: 140 EAEQRPEVPEGSA-------------------SGEAGDSVDAEGPLGDNIEAEGPA---G 177
Query: 215 PKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPE- 273
+ R + E AG++ + AEG G+ + A +S A G G + E
Sbjct: 178 DSVEAEGRVGDSVDAEGPAGDSVD--AEGP-LGDNIQAEGPAGDSVDAEGRVGDSVDAEG 234
Query: 274 DWGILGREEARTTPGREEARAILDGEEARTISGGE-EAETASGGE-EAETASGGEE--AG 329
G E R E DG EA +G EAE +G +AE +G +G
Sbjct: 235 PAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSG 294
Query: 330 TASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGER 389
+ ++ EA + GE AG S G+ AW + EEA++ GV+ +E A PG+
Sbjct: 295 EPQQSGDGSLSPQAEAIEVAAGESAG-RSPGELAWDAA--EEAEVPGVKGSE-EAAPGDA 350
Query: 390 LLEATGKVWV----LEEEGDEEREAEVSP-FPKQPQVLGTERTEEAAESQTAGREAVGGQ 444
+A G+ V +E G++E E SP P++ + G E EE+ +S G + G
Sbjct: 351 RADA-GEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGE--EESPDSSPHGEASRGAA 407
Query: 445 E 445
E
Sbjct: 408 E 408
Score = 50.4 bits (119), Expect = 9e-06
Identities = 115/506 (22%), Positives = 161/506 (31%), Gaps = 122/506 (24%)
Query: 41 AQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGP-GDDRRHEVGSSAVEQ 99
A+AAE GV A G G E L G G GP G + E A
Sbjct: 2 AEAAEPEGV-APGPQGP---PEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAV 57
Query: 100 TWGWGDGSSHGSQAERQ-----------DSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
G G G +AE + + GA E A+ + E ++ + + + G GA
Sbjct: 58 KEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGA 117
Query: 149 CQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEG 208
+ G+AQ E E++EE E+ P + G+ S GE
Sbjct: 118 QGEPRGEAQREPEDSAAP----------ERQEEAEQ----RPEVPEGSAS-----GEAGD 158
Query: 209 KAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGP 268
A GP GDN E E AG++ E AEG + +S A G G
Sbjct: 159 SVDAEGP--LGDNIEAE-----GPAGDSVE--AEG-----------RVGDSVDAEGPAGD 198
Query: 269 GAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEA 328
+ E G LG P + A E R + A +AE G
Sbjct: 199 SVDAE--GPLGDNIQAEGPAGDSVDA-----EGRVGDSVDAEGPAGDSVDAE----GRVG 247
Query: 329 GTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGE 388
+ G+ AG G EAG +G GD
Sbjct: 248 DSVEAGDPAG--DGVEAGVPAGDSVEAEGPAGDS-------------------------- 279
Query: 389 RLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGE 448
++ EG R VS P+Q + + Q E G+ AG
Sbjct: 280 -----------MDAEGPAGRARRVSGEPQQSG-------DGSLSPQAEAIEVAAGESAGR 321
Query: 449 SFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGT 508
S E+ D A+ ++ +A + D V + P E
Sbjct: 322 S----------PGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDE 371
Query: 509 ADLEATPEARPEEELTGEESEAAQTS 534
E +PE EEE G E E+ +S
Sbjct: 372 ERRERSPEGPREEEAAGGEEESPDSS 397
Score = 38.5 bits (88), Expect = 0.035
Identities = 81/332 (24%), Positives = 113/332 (34%), Gaps = 28/332 (8%)
Query: 33 AVPTVEREAQAAEELGV-VAVGKTGKIVEEEA----QEDLEGLRGSQNEGAGRLRGPGDD 87
A P + EA+ E+ A G+ G V+ E + EG G E GR+ G D
Sbjct: 133 AAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRV-GDSVD 191
Query: 88 RRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSG 147
G S V+ GD A G + + P+ + S
Sbjct: 192 AEGPAGDS-VDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSV 250
Query: 148 ACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETE 207
D +G E V E + E RAR E + + G
Sbjct: 251 EAGDPAGDGVEAGVPAGDSVEAEGPAGD-SMDAEGPAGRARRVS----GEPQQSGDGSLS 305
Query: 208 GKAGAVGPKAAGDNREMEQGVREADAGETEE-PGAEGAGKGEEVVVVEKACESTRAWGTW 266
+A A+ AAG++ G DA E E PG +G+ EE + ++
Sbjct: 306 PQAEAI-EVAAGESAGRSPGELAWDAAEEAEVPGVKGS---EEAAPGDARADAGEDRVGD 361
Query: 267 GPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGE 326
GP EP G R+ G E A EE+ S EA + EA+ ++
Sbjct: 362 GPQQEP---GEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLA 418
Query: 327 EAGTASGGEEAGIASGGEAGTASGGEEAGTAS 358
E G A G GEA +G E G AS
Sbjct: 419 EEGPAEG--------SGEAARVNGRREDGEAS 442
Score = 35.4 bits (80), Expect = 0.30
Identities = 64/236 (27%), Positives = 85/236 (36%), Gaps = 44/236 (18%)
Query: 31 GDAVPTVEREAQAAEEL--------GVVAVGKTGKIVEEEAQE----DLEGLRGSQNEGA 78
G A +V+ E + + + GV A G VE E D EG G +
Sbjct: 234 GPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVS 293
Query: 79 GRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEA 138
G + GD + A+E G G S G A D+ + E +A +A
Sbjct: 294 GEPQQSGDGSLSPQ-AEAIEVAAGESAGRSPGELA--WDAAEEAEVPGVKGSEEAAPGDA 350
Query: 139 RKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAES 198
R + A +DR G + QE E E RE RS E EEE E
Sbjct: 351 R------ADAGEDRVGDGPQ-QEPGEDEERRE---RSPEGPREEEAAGGEEES------P 394
Query: 199 EWTWHGETEGKAGAVGPKAAGDNREMEQGVREA-----------DAGETEEPGAEG 243
+ + HGE GA P+A N E+G E + GE EP A G
Sbjct: 395 DSSPHGEAS--RGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALG 448
>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
Length = 673
Score = 69.3 bits (168), Expect = 2e-11
Identities = 119/447 (26%), Positives = 178/447 (39%), Gaps = 81/447 (18%)
Query: 206 TEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVV----EKACESTR 261
+EG+ G K G + +G+R + T G E K EEVV+ K S
Sbjct: 205 SEGRVGEA--KGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLE 262
Query: 262 --------------AWGTWGPGAEPEDWGILGR--EEARTTPGRE----EARAILDGEEA 301
W G G++ E G +GR E +T+ R EA A ++GE+
Sbjct: 263 LPAWVKEDRGIVEVVWEGVG-GSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDV 321
Query: 302 RTISGGEEAETASGGEE-----AETASGGEE-----AGTASGGEEAGIASGGEAGTASGG 351
S + + SGGEE E + EE G E AG G E+ + G
Sbjct: 322 PQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEG 381
Query: 352 EEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAE 411
+ G GG+E W ++ + +G+ E PG EA V + G+++ E E
Sbjct: 382 AKTG---GGEETWEAEKRKAEESMGIGSEE---KPGTGRDEAEMSPVVERKGGEKKLELE 435
Query: 412 VSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRG-KEAEMRQDLGIR 470
+ LGTER E E V G E EG + RG +E E+ + LG+
Sbjct: 436 SR---GSAEKLGTER--EGGEEPLGIERKVEGHLRAEK-EGDEEKRGAEEEEVEEPLGV- 488
Query: 471 ADRARMEELVQAEEAQEERGSSRDPVA-ELPSDGEAEGTADLEATPEARPEEELTGEESE 529
E++G +P A + P + E +G + + EE L E+E
Sbjct: 489 ----------------EKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESL---ETE 529
Query: 530 AAQTSCGLLGVEWGGLTHSVTKGQ-----GPELMGGAQT-PTK---QPEEREAGEVELMG 580
Q + G L +E G S ++ + GP L +T P K QP+E+ G +E G
Sbjct: 530 KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEG 589
Query: 581 VLALSKEEQERSL-EAGPRHAGSVKPE 606
V + E + L +A P A + PE
Sbjct: 590 VKPQTAAEGQGPLGDATPLLAETPAPE 616
Score = 57.4 bits (137), Expect = 7e-08
Identities = 99/400 (24%), Positives = 146/400 (36%), Gaps = 60/400 (15%)
Query: 217 AAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWG 276
A+ + ++ QG E D G+ G EG+ E V + + E G GP
Sbjct: 314 ASIEGEDVPQGSPEGD-GQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPE------- 365
Query: 277 ILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEE 336
+ GRE +P E GEE + E+ G E + +G +EA + E
Sbjct: 366 VAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER 425
Query: 337 AGIASGGEAGTASGGEEAGT-ASGGDEAWTTSGKEEADLLGVRQ--TEYGAVPGERLLEA 393
G E + E+ GT GG+E K E L ++ E E + E
Sbjct: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
Query: 394 TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQ 453
G +E++G EE E E + P + + G E T EA E GG+E+ E+ + Q
Sbjct: 486 LG----VEKKGGEE-EPEATKEPLEAERKGGEETLEA--------EKRGGEESLETEKTQ 532
Query: 454 VDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEA 513
G E ++ + G R + E+Q E + P LEA
Sbjct: 533 ----GTEGDLNLEQGSR----------EGSESQAEEMNEAGP--------------PLEA 564
Query: 514 TPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREA 573
E RPE+ E + + G L E G + +GQGP G TP
Sbjct: 565 NTETRPEK----EGPQPQEKPVGALEEE-GVKPQTAAEGQGPL---GDATPLLAETPAPE 616
Query: 574 GEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPG 613
E +L S P +A + +PE S G
Sbjct: 617 QPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEG 656
Score = 57.0 bits (136), Expect = 9e-08
Identities = 167/661 (25%), Positives = 244/661 (36%), Gaps = 82/661 (12%)
Query: 464 RQDLGIRADRARMEELVQA--EEAQEE--------RGSSR-----DPVAELPSDGEAEGT 508
RQ L + A++ R++E ++A E +EE R S R D A +P E +
Sbjct: 8 RQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTS 67
Query: 509 ADLEATPEARPEEELTGEESE--AAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTK 566
D ++ PE + + + E Q+ LL G H + G
Sbjct: 68 KDPQS-PEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQS 126
Query: 567 QPEEREAGEVEL-------MGVLALSKEEQERSLE------AGPRHAGSVKPEASEAFPG 613
E G+ +L G++ E E GPR ++SEA G
Sbjct: 127 IVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEA-NG 185
Query: 614 AWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLT 673
+ E+G +Q A E R E GG ++ EG R +E G E
Sbjct: 186 PCPSPIPTP-EQGLSQR-AVPSEGRVGEAKGGG-VVSVVWEGLRATEDCATGATGPELEA 242
Query: 674 TQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRL 733
+ G+ + + EL D G + E + E R +
Sbjct: 243 KVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEV---V 299
Query: 734 QAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGE 793
Q + L +R +A AA I G DV P S G G+ G G+ E E
Sbjct: 300 QTSSPRLQERLEA-----AASIEGEDV-PQGSPEGDGQGGSG--GEEGSFIWVERVTLSE 351
Query: 794 HAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEA--EESAGAEDSCGL---DP 848
+E +EG EV GR E+ EG GG E E AE+S G+ +
Sbjct: 352 E--WEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEK 409
Query: 849 AGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQER--EQREDSEGRCGDYHPEGEAPR 906
G+ AE M +VE G +K LE E+ G E+ +RE E G E +
Sbjct: 410 PGTGRDEAE-MSPVVERKGGEKK---LELESRGSAEKLGTEREGGEEPLGI---ERKVEG 462
Query: 907 LLDAEGLMVTGGRRAEAKETE-PESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGS 965
L AE R AE +E E P +E G+EE + P EA E G ET EA
Sbjct: 463 HLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEA--ERKGGEETLEA--E 518
Query: 966 ARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNP 1025
RGG + +E G+ D+++ + S S ++ + E + E P P
Sbjct: 519 KRGGEESLETE-KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQP 577
Query: 1026 PEEELSAPEQRPLQLEEPLEPSPLRHDGTPV---------PARRRPLGHGFG-----LAH 1071
E+ + A E+ ++ + E D TP+ PA +PL G G AH
Sbjct: 578 QEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAH 637
Query: 1072 P 1072
P
Sbjct: 638 P 638
Score = 49.3 bits (116), Expect = 2e-05
Identities = 126/520 (24%), Positives = 190/520 (36%), Gaps = 78/520 (15%)
Query: 378 RQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAG 437
R+ G +PG R + + E SP P Q L ++ A S+
Sbjct: 160 REDVLGFLPGPRQVPGAAG------DSSEANGPCPSPIPTPEQGL----SQRAVPSEGRV 209
Query: 438 REAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVA 497
EA GG +EG LR E G + A++EE+V + S + A
Sbjct: 210 GEAKGGGVVSVVWEG---LRATEDCATGATGPELE-AKVEEVVLEAIGDRKGAGSLELPA 265
Query: 498 ELPSDG-------EAEGTADLEATPEARPEEELTGEESEAAQTSC-GLLGVEWGGLTHSV 549
+ D E G +D EA E E+ S Q +E +
Sbjct: 266 WVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGS 325
Query: 550 TKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEA--GPRHAGSVKPEA 607
+G G GG E G + + LS+E +E +E GP AG + +
Sbjct: 326 PEGDGQGGSGG-----------EEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDE 374
Query: 608 SEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPE- 666
S GA +T E+ + E+R+ EE+ G + G E+E+S V E
Sbjct: 375 SPL--GAEGAKT-------GGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER 425
Query: 667 AGGEGL-------TTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDE 719
GGE + + G E GE + ++++G A+ G+ R E+E
Sbjct: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAE-----KEGDEEKRGAEEE 480
Query: 720 EAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQ 779
E E L G + +A + A GG+ G E+LE Q
Sbjct: 481 EVEEP--------LGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQ 532
Query: 780 GWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAG 839
G + E + E G E S EE+ G +EA G + + E+ G
Sbjct: 533 GTEGDLNLEQGSRE---GSE-----SQAEEMNEAGPPLEANTETRPEKEGPQPQ-EKPVG 583
Query: 840 AEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEA 879
A + G+ P QTA AEG G + +A LL + E+ A
Sbjct: 584 ALEEEGVKP---QTA-AEGQGPLGDATPLLAETPAPEQPA 619
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 67.4 bits (163), Expect = 7e-11
Identities = 183/939 (19%), Positives = 314/939 (33%), Gaps = 149/939 (15%)
Query: 106 GSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQ 165
G HGS+ +Q + + + R Q+ S ++ + +GS A D G ++E S Q
Sbjct: 1678 GERHGSR-HQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQA-SDSEGHSEE---SDTQ 1732
Query: 166 EVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTW----HGETEGKAGAVGPKAAGDN 221
V+ + +Q +E + G G + + H ++E G GP G
Sbjct: 1733 SVSAHGQAGPHQQSHQEST--RGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQ 1790
Query: 222 REMEQGVREADAGETEEPGAE------GAGKG-EEVVVVEKACESTRAWGTWGPGAEPED 274
R + R++ + G + G+ +G + E++ +S+ G+ ++
Sbjct: 1791 RSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQE 1850
Query: 275 WGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGG 334
+ R ++ + + R + SG E +S + + + G+ G +SG
Sbjct: 1851 RSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQ--GQSSGP 1908
Query: 335 EEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAV-PGERLLEA 393
S + + S ++ S E W+ S Q+ G+ PG +
Sbjct: 1909 R----TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDR 1964
Query: 394 TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQ 453
G D R++ GT TE ++ Q A AGE
Sbjct: 1965 AGH----GHSADSSRQS------------GTRHTESSSRGQAASSHEQARSSAGERHGSH 2008
Query: 454 VDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEA 513
L+ ++ +G + A RG S ++ E T + A
Sbjct: 2009 HQLQSADSSRHSGIG-------HGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSA 2061
Query: 514 TPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSV--------TKGQGPELMGGAQ--- 562
+A P ++ E+A+ G G + V T GQ GG Q
Sbjct: 2062 QGKAGPHQQ---SHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSH 2118
Query: 563 ----TPTKQPEEREAGEVELMGVLALSK-----EEQERSLEAGPRHAGSVKPEASEAFPG 613
+ + + G+ + G S+ QE+S++ H+GS +
Sbjct: 2119 YDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRS-GHSGSHHSHTT----- 2172
Query: 614 AWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLT 673
++ R D RG + +A + ++E++ G + G E S ++ L
Sbjct: 2173 ---SQGRSDASRGQSGSRSASRKTYDKEQSGDG----SRHSGSHHHEASSWADSSRHSLV 2225
Query: 674 TQDAGCGTEEGE---ASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRG 730
Q G +SVS++ + +G + S + +++ + R R
Sbjct: 2226 GQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSH 2285
Query: 731 WRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAA 790
+A G Q+G+ A G AA + E G+ S ++ A
Sbjct: 2286 HEDRA-GHGHSAESSRQSGTHHAENSSGG-----QAASSHEQARSSAGERHGSHHQQSAD 2339
Query: 791 AGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAG 850
+ H+ G G SA + RGS EG +S A G
Sbjct: 2340 SSRHS-GIGHGQASSAVRDSGHRGSSGSQASDSEG---HSEDSDTQSVSAHGQAGPHQQS 2395
Query: 851 SQ-TARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLD 909
Q + R G +G L + + EQ E + GR G
Sbjct: 2396 HQESTRGRSAGRSGRSGSFLYQVS----------THEQSESAHGRTG------------- 2432
Query: 910 AEGLMVTGGRRAEAKETEPESLEHVRGQEEQPT-HQAPAEAAPESVGEAETAEAMGSARG 968
TGGR+ + +S H QE Q T H P GS+ G
Sbjct: 2433 ----TSTGGRQGSHHKQARDSSRHSTSQEGQDTIHGHP-----------------GSSSG 2471
Query: 969 GAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPS 1007
G S E L+D S S H S ++SQ RS S
Sbjct: 2472 GRQGSHYE-----QLVDRS-GHSGSHHSHTTSQGRSDAS 2504
Score = 59.3 bits (142), Expect = 2e-08
Identities = 201/1024 (19%), Positives = 341/1024 (33%), Gaps = 151/1024 (14%)
Query: 62 EAQEDLEGLRGSQNEGAG-RLRGPGDDRRHE-----VGSSAVEQTWGWGDGSSHGSQAER 115
+A E R S E G R + D RH SSAV + WG S S +E
Sbjct: 1017 QAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEG 1076
Query: 116 QDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRS 175
+ + + Q+ ++ ++ SG RSG + +HEQ + R R+
Sbjct: 1077 HSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRT 1136
Query: 176 ---------WEQ----------EEEEEEVRAREPGMARGA-------------------E 197
EQ +E ++ +RA PG RG
Sbjct: 1137 STGRRQGSHHEQARDSSRHSASQEGQDTIRA-HPGSRRGGRQGSHHEQSVDRSGHSGSHH 1195
Query: 198 SEWTWHGETEGKAGAVGPKAAG--DNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEK 255
S T G ++ G G ++A ++ + G +G A A V ++
Sbjct: 1196 SHTTSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQE 1255
Query: 256 ACESTRAWGTWGPGAEPEDWGILGREEARTTPG----------REEARAILDGEEARTIS 305
+R G + +++ G RE++R DG
Sbjct: 1256 QSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSR---DGSRH---P 1309
Query: 306 GGEEAETASGGEEAETA--SGGEEAGTASGGEEAGIASGGEAGTASGGEEAGT---ASGG 360
G + + AS G A+++ SG ++S G+ S E +S GE G+ S
Sbjct: 1310 GFHQEDRASHGHSADSSRQSGTHHTESSSHGQ---AVSSHEQARSSPGERHGSRHQQSAD 1366
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEE---REAEVSPFPK 417
+ G +A VR + + G ++ + G E+ D + + P +
Sbjct: 1367 SSRHSGIGHRQAS-SAVRDSGHRGSSGSQVTNSEGH----SEDSDTQSVSAHGQAGPHQQ 1421
Query: 418 QPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARME 477
+ ++ E++ + V E ES GQ RQ G R ++AR
Sbjct: 1422 SHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQT---APSTGGRQ--GSRHEQARNS 1476
Query: 478 ELVQAEEAQEE---------RGSSRDPVAELPSDGEA-EGTADLEATPEARPEEE--LTG 525
A + ++ RG + E D G TP+ R + +G
Sbjct: 1477 SRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSG 1536
Query: 526 EESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGE---------- 575
S + QT + G HS ++ P G+ ++ + AG
Sbjct: 1537 PRSASRQTRNEEQSGD--GSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSV 1594
Query: 576 VELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKD--MERGNTQEDAA 633
+ S++ + RS A H GS + ++ G+ R+ ++ G++ E +
Sbjct: 1595 SQDRDSEGHSEDSERRSESASRNHYGSAREQSRH---GSRNPRSHQEDRASHGHSAESSR 1651
Query: 634 DGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQE 693
R E ++GGQ A +E S E G Q A T+ G +
Sbjct: 1652 QSGTRHAETSSGGQ-----AASSQEQARSSPGERHG-SRHQQSADSSTDSG-----TGRR 1700
Query: 694 LDGSTGADAGPCPSLG-EAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVA 752
D S D+G S G +A E EE++ S G QA +E + S
Sbjct: 1701 QDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHG---QAGPHQQSHQESTRGQSGE 1757
Query: 753 AGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTG 812
G + +S E+ G G +++ + EG + T
Sbjct: 1758 RSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEG----QDTI 1813
Query: 813 RGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKW 872
RG + R+G + V++ +G+ S S +R + V EK
Sbjct: 1814 RGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQ 1873
Query: 873 TLLEEEAVGWQERE--QREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPE- 929
+ G + E R DS + PR +G V+ ++ + E
Sbjct: 1874 SGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSER 1933
Query: 930 -----SLEHVRGQEEQPT--HQAPAEAAPESVGEAETAEAM---------GSARGGAANS 973
S H+ EQ + P + G +A++ S+RG AA+S
Sbjct: 1934 WSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASS 1993
Query: 974 WSEA 977
+A
Sbjct: 1994 HEQA 1997
Score = 56.2 bits (134), Expect = 2e-07
Identities = 176/949 (18%), Positives = 292/949 (30%), Gaps = 110/949 (11%)
Query: 86 DDRRHEVGSSAVEQTWGWG---DGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKS 142
D RH +S W DGS H + + G +A ++R Q + H E +
Sbjct: 309 DSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSR-QSGTRHAETSSRG 367
Query: 143 KAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTW 202
+ S Q RS + H+Q + + + G + S+
Sbjct: 368 QTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEG 427
Query: 203 HGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRA 262
H E G AG ++ Q E+ G + G G + V + A
Sbjct: 428 HSENSDTQSVSGHGKAGLRQQSHQ---ESTRGRS---GERSGRSGSSLYQVSTHEQPDSA 481
Query: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETA 322
G G GR+ + R+ +R E TI G ++ GG +
Sbjct: 482 HGRTGTSTG-------GRQGSHHEQARDSSRHSASQEGQDTIRG--HPGSSRGGRQGSHH 532
Query: 323 SGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEY 382
SG + S G + + G SG A + EE G R +
Sbjct: 533 EQSVNRSGHSGSHHSHTTSQGRSDASHG------QSGSRSASRQTRNEEQSGDGTRHS-- 584
Query: 383 GAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVG 442
G R EA+ + D R ++V Q Q G + S + ++ G
Sbjct: 585 ----GSRHHEAS-------SQADSSRHSQVG----QGQSSGPRTSRNQGSSVSQDSDSQG 629
Query: 443 GQEAGESFEGQV--DLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELP 500
E E + G + G E +D G R R+ E+ + + S +
Sbjct: 630 HSEDSERWSGSASRNHHGSAQEQSRD-GSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNS 688
Query: 501 SDGEAEGTADLEATPEARPEE-ELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMG 559
S G+A + + +AR E G + G S + G
Sbjct: 689 SSGQAASSHE-----QARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSS 743
Query: 560 GAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRT 619
G+Q + ++ + G +Q S + R + S +F ++ T
Sbjct: 744 GSQATDSEGHSEDSDTQSVSGHGQAGHHQQ--SHQESARDRSGERSRRSGSF--LYQVST 799
Query: 620 RKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGC 679
K E + + G ++ A D + + P + G
Sbjct: 800 HKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQ 859
Query: 680 GTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVG 739
+ S S + +DA S + +R T +EE D + G R +
Sbjct: 860 SVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSH 919
Query: 740 LPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAG-GQ 798
+Q G G G + + + G DS+ +A+ H G Q
Sbjct: 920 ADISRHSQAGQ---GQSEGSRTSRRQGSSVSQDSDSE-GHSEDSERWSGSASRNHRGSAQ 975
Query: 799 EFGLEGSA-----EEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQT 853
E GS E+ G G ++ SR+ G AE S+G + + + A S
Sbjct: 976 EQSRHGSRHPRSHHEDRAGHGHSADS--SRQ----SGTPHAETSSGGQAASSHEQARSSP 1029
Query: 854 ARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGL 913
G +Q DS G P +A + G
Sbjct: 1030 GERHG------------------------SRHQQSADSSRHSG--IPRRQASSAVRDSGH 1063
Query: 914 MVTGGRRAEAKE--TEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAA 971
+ G +A E +E + V G + HQ E+A R G +
Sbjct: 1064 WGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQ---------SHQESARDWSGGRSGRS 1114
Query: 972 NSWSEAPLPGSLLDVSVPRSRVHLSR--SSSQRRSRPSFRRTPAWEQQE 1018
S+ + + R+R R S ++R S R + + E Q+
Sbjct: 1115 GSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQD 1163
Score = 55.8 bits (133), Expect = 2e-07
Identities = 136/758 (17%), Positives = 239/758 (31%), Gaps = 67/758 (8%)
Query: 61 EEAQEDLEGLRGSQNEGAGRLR-----GPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAER 115
+ Q EG R S+ +G+ + G +D GS++ + S HGS+ R
Sbjct: 3196 QAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPR 3255
Query: 116 QD----SGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREE 171
+G G +A +R Q + H E +A S Q RS + H+Q +
Sbjct: 3256 SHHEDRAGHGHSADRSR-QSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSAD-SS 3313
Query: 172 RLRSWEQEEEEEEVR-AREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVRE 230
R + + VR +R G + S+ H E G AG +++ Q
Sbjct: 3314 RHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQ---- 3369
Query: 231 ADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGRE 290
+ G G + V +S A G RT+ GR
Sbjct: 3370 --ESARDRSGGRSGRSGSFLYQVSTHEQSESAHG-----------------RTRTSTGRR 3410
Query: 291 EARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASG 350
+ ++ S +E + G + G + + + +G + + T S
Sbjct: 3411 QGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQ 3470
Query: 351 GEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREA 410
G D + SG A RQT G+ + W E + ++
Sbjct: 3471 GRS-------DASRGQSGSRSAS----RQTRNDEQSGD----GSRHSWSHHHEASTQADS 3515
Query: 411 EVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDL--RGKEAEMRQDLG 468
Q Q G + S + ++ G E E + G RG E +D G
Sbjct: 3516 SRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRD-G 3574
Query: 469 IRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEE-ELTGEE 527
R + E+ + E S AE S G+A + + +AR E G
Sbjct: 3575 SRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHE-----QARSSAGERHGSH 3629
Query: 528 SEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKE 587
+ + S G+ G + +V + G G+Q + ++ +
Sbjct: 3630 HQQSADSSRHSGIGHGQASSAV-RDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPH 3688
Query: 588 EQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQ 647
+Q R AG S + + ++ R G + E+ +
Sbjct: 3689 QQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRH 3748
Query: 648 TLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPS 707
+ + E + G +G + + + S S + +DA S
Sbjct: 3749 SASQEGQDTIRGHPGS-RRGGRQGSYHEQS---VDRSGHSGSHHSHTTSQGRSDASHGQS 3804
Query: 708 LGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAA 767
+ +RET +EE D + G R + +Q+G G G +
Sbjct: 3805 GSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSGQ---GESAGSRRSRRQGS 3861
Query: 768 GAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGS 805
+ + + E A+ H +E +GS
Sbjct: 3862 SVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGS 3899
Score = 55.1 bits (131), Expect = 4e-07
Identities = 192/1013 (18%), Positives = 327/1013 (32%), Gaps = 150/1013 (14%)
Query: 85 GDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGET----AKAARCQEPSAHLEARK 140
GD RH S + W D S H + Q SG + + ++ + H E +
Sbjct: 2200 GDGSRHS--GSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSE 2257
Query: 141 KSKAGSGACQDRSGQAQERQESHEQEVNREERL---RSWEQEEEEEEVRAREPGMARGAE 197
+ + S Q Q R S + E+R S E + A + A
Sbjct: 2258 RRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAAS 2317
Query: 198 SEWTWHGETEGKAGAVGPKAAGDNREMEQGVREA-----DAGETEEPGAEGAGKGEEVVV 252
S + G+ ++A +R G +A D+G G++ + E
Sbjct: 2318 SHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDS--EGHS 2375
Query: 253 VEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAET 312
+ +S A G GP + GR R+ + E++ + G T
Sbjct: 2376 EDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHG--RTGT 2433
Query: 313 ASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTA---------SGGDEA 363
++GG + ++ S +E G G++SGG + SG +
Sbjct: 2434 STGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHS 2493
Query: 364 WTTS-GKEEAD------LLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFP 416
TTS G+ +A RQT G+ + + D ++V
Sbjct: 2494 HTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVG--- 2550
Query: 417 KQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLR--GKEAEMRQDLGIRADRA 474
Q Q G + S + ++ G E E + G G E +D G R R+
Sbjct: 2551 -QGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRD-GSRHPRS 2608
Query: 475 RMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEE-ELTGEESEAAQT 533
E+ + + S + S G+A + + +AR E G + +
Sbjct: 2609 HQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHE-----QARSSAGERHGSHHQQSAD 2663
Query: 534 SCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQ--PEEREAGEVELMGVLALSKEEQER 591
S G+ G + +V + G G+Q + E+ + V G ++ +
Sbjct: 2664 SSRHSGIGHGQASSAV-RDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQE 2722
Query: 592 SLEAGPR----HAGSV--------KPEASEAFPGAWENRTRKDMERGNTQEDAADGEQRE 639
S H+GS + E+S + G R R+ Q+ + ++
Sbjct: 2723 SARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGP-STRGRQGSRHEQAQDSSRHSASQD 2781
Query: 640 EEETAGGQTLAAEAEGDRESELSE--VPEAGGEGL----TTQDAGCGTEEGEAS------ 687
++T G + G R+ E V +G G TT G++
Sbjct: 2782 GQDTIRGHP--GSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASR 2839
Query: 688 VSENQELDGSTGADAGPCPSLGEAYARETEDEEA-----EADRTSRR-GWRLQAVAVGLP 741
+ N+E G +G +A + +A E R SRR G + +
Sbjct: 2840 TTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEG 2899
Query: 742 DREDAQT----------GSVAAGIMGGDVVPHI---SAAGAGEALEGVL----------- 777
ED++ GS + G P AG G + +
Sbjct: 2900 HSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSS 2959
Query: 778 -GQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEE 836
GQ S E+ ++AGE G S+ G G A + G ++
Sbjct: 2960 GGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDN 3019
Query: 837 SAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCG 896
+EDS +Q+ A G G ++ +E + GR G
Sbjct: 3020 EGHSEDS------DTQSVSAHGQ--------------------AGSHQQSHQESARGRSG 3053
Query: 897 DYHPEGEAPRLLDAEGLMVTGGRRAEAKE--TEPESLEHVRGQEEQPTHQAPAEAAPESV 954
+ G + L V+ ++E+ T P + + EQ Q + +
Sbjct: 3054 E--TSGHSGSFL----YQVSTHEQSESSHGWTGPSTRGRQGSRHEQA--QDSSRHSASQY 3105
Query: 955 GEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPS 1007
G+ GS+RGG E + S S H S ++SQ RS S
Sbjct: 3106 GQDTIRGHPGSSRGGRQGYHHEHSVDSS------GHSGSHHSHTTSQGRSDAS 3152
Score = 54.7 bits (130), Expect = 5e-07
Identities = 204/1012 (20%), Positives = 329/1012 (32%), Gaps = 129/1012 (12%)
Query: 73 SQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEP 132
SQ R G R+ +GS A EQ+ DGS H +G G +A ++R Q
Sbjct: 1924 SQGHSEDSERWSGSASRNHLGS-AWEQS---RDGSRHPGSHHEDRAGHGHSADSSR-QSG 1978
Query: 133 SAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVR-AREPG 191
+ H E+ + +A S Q RS + H+ + R + VR + G
Sbjct: 1979 TRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRG 2038
Query: 192 MARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVV 251
+ S+ H E AG + +Q +E+ G++ E +V
Sbjct: 2039 YSGSQASDSEGHSEDSDTQSVSAQGKAGPH---QQSHKESARGQSGESSGRSGSFLYQVS 2095
Query: 252 VVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISG----- 306
E++ EST G GR+ + ++ +R E TI G
Sbjct: 2096 THEQS-ESTHGQSAPSTG---------GRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPS 2145
Query: 307 --GEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGG------EEAGTAS 358
G + + SG + T S G AS G++G+ S E++G S
Sbjct: 2146 RGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSD--ASRGQSGSRSASRKTYDKEQSGDGS 2203
Query: 359 GGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPF--- 415
+ AD G G R G + ++ D E +E S
Sbjct: 2204 RHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSS--VSQDSDSEGHSEDSERRSG 2261
Query: 416 -----------------PKQPQVLGTERT------EEAAESQTAGREAVGGQEAGESFEG 452
+ P+ +R E + +S T E G +A S E
Sbjct: 2262 SASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQ 2321
Query: 453 QVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEE---RGSSRDPVAELPSDGEAEGTA 509
G+ + R QA A + RGSS ++ E T
Sbjct: 2322 ARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQ 2381
Query: 510 DLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPE 569
+ A +A P ++ E + S G G L T Q G T T +
Sbjct: 2382 SVSAHGQAGPHQQSHQESTRGR--SAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQ 2439
Query: 570 EREAGEVELMGVLALSKEEQER------SLEAGPRHAGSVKPEASEAFPGAWENRT---- 619
+ + S+E Q+ S G + + + G+ + T
Sbjct: 2440 GSHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQG 2499
Query: 620 RKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGC 679
R D G++ +A + R +E++ G + G R E S ++ G G
Sbjct: 2500 RSDASHGHSGSRSASRQTRNDEQSGDG----SRHSGSRHHEASSRADSSGHS----QVGQ 2551
Query: 680 GTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVG 739
G EG + S N S +D+ + ++ ++E A R + G + + G
Sbjct: 2552 GQSEGPRT-SRNWGSSFSQDSDS-------QGHSEDSERWSGSASR-NHHGSAQEQLRDG 2602
Query: 740 LPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQE 799
R AG G +G GQ S E+ ++AGE G
Sbjct: 2603 --SRHPRSHQEDRAG--HGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHH 2658
Query: 800 FGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDS-----CGLDPAGS--- 851
S+ G G A + G ++ +EDS AGS
Sbjct: 2659 QQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQ 2718
Query: 852 ---QTARAEGMGAMVEAGGLLEKWTLLE--EEAVGWQEREQREDSEGRCGDYHPEG-EAP 905
++AR +G L + + E E + GW R GR G H + ++
Sbjct: 2719 SHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTR----GRQGSRHEQAQDSS 2774
Query: 906 RLLDAEGLMVT---------GGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGE 956
R ++ T GGR+ E +S H T Q ++A+ G
Sbjct: 2775 RHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGS 2834
Query: 957 ---AETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSR 1005
+ T + G+ +S S + D+S S+ +S RRSR
Sbjct: 2835 RSASRTTRNEEQSGDGSRHSGSRHHEASTHADIS-RHSQAVQGQSEGSRRSR 2885
Score = 54.3 bits (129), Expect = 6e-07
Identities = 195/983 (19%), Positives = 306/983 (31%), Gaps = 176/983 (17%)
Query: 64 QEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGS---QAERQDSGA 120
Q G S +E A G RH++ S+ + G G G + + R SG+
Sbjct: 686 QNSSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGS 745
Query: 121 GET-----AKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRS 175
T ++ + Q S H +A ++ + +DRSG+ R S +V+ ++
Sbjct: 746 QATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQ--- 802
Query: 176 WEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDN--REMEQGVREADA 233
+ES W G + G + A DN Q ++
Sbjct: 803 --------------------SESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIR 842
Query: 234 GETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILG-REEARTTPGREEA 292
G G E V + T G G G R +RTT E++
Sbjct: 843 GHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQS 902
Query: 293 RAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGE 352
R DG SG E +S + + + G+ G E S + + S
Sbjct: 903 R---DGSRH---SGSRHHEASSHADISRHSQAGQ------GQSEGSRTSRRQGSSVSQDS 950
Query: 353 EAGTASGGDEAWTTSGKEEADLLGVRQTEYGA-VPGERLLEATGKVWVLEEEGDEEREAE 411
++ S E W+ S Q+ +G+ P + G D R++
Sbjct: 951 DSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGH----GHSADSSRQS- 1005
Query: 412 VSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRA 471
GT E ++ Q A GE + + A+ + GI
Sbjct: 1006 -----------GTPHAETSSGGQAASSHEQARSSPGERHGSR---HQQSADSSRHSGIPR 1051
Query: 472 DRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAA 531
+A A GSS ++ E T + + P ++ + A
Sbjct: 1052 RQAS-----SAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQ--SHQESAR 1104
Query: 532 QTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQE- 590
S G G + T Q G +T T + + + + S+E Q+
Sbjct: 1105 DWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDT 1164
Query: 591 --------RSLEAGPRHAGSV-KPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEE 641
R G H SV + S + ++ R D G + +A + R+++
Sbjct: 1165 IRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDK 1224
Query: 642 ETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGAD 701
++ G + G R E A + V + Q T
Sbjct: 1225 QSGDG----SRHSGSRHHEA---------------ASWADSSRHSQVGQEQSSGSRTSRH 1265
Query: 702 AGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVV 761
G S R ++D E + SR RE ++ GS G D
Sbjct: 1266 QGSSVSQDSDSERHSDDSERLSGSASRNHHG--------SSREQSRDGSRHPGFHQEDRA 1317
Query: 762 PHISAA------GAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGS 815
H +A G GQ S E+ ++ GE G +
Sbjct: 1318 SHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRH---------------- 1361
Query: 816 QVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMG-----AMVEAGGLLE 870
Q A SR G G R + S+ DS +GSQ +EG V A G
Sbjct: 1362 QQSADSSRHSG-IGHR---QASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAG 1417
Query: 871 KWTLLEEEAVGWQEREQREDSEGRCGDY------HPEGEAPRLLDAEGLMVTGGRRAEAK 924
+E+ R Q +S GR + H + E+ A TGGR+
Sbjct: 1418 PHQQSHKESA----RGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPS---TGGRQGSRH 1470
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLL 984
E S H Q+ Q T + GS+RGG S+ E + S
Sbjct: 1471 EQARNSSRHSASQDGQDTIRGHP----------------GSSRGGRQGSYHEQSVDRS-- 1512
Query: 985 DVSVPRSRVHLSRSSSQRRSRPS 1007
S H S ++ Q RS S
Sbjct: 1513 ----GHSGYHHSHTTPQGRSDAS 1531
Score = 54.3 bits (129), Expect = 6e-07
Identities = 209/1031 (20%), Positives = 322/1031 (31%), Gaps = 181/1031 (17%)
Query: 38 EREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAV 97
E ++ ++ V A G+ G Q E RG E +G G
Sbjct: 3020 EGHSEDSDTQSVSAHGQAGS----HQQSHQESARGRSGETSGH---SGSFLYQVSTHEQS 3072
Query: 98 EQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGS--GACQDRSGQ 155
E + GW S+ G Q R + A ++++ + Q + S G G + S
Sbjct: 3073 ESSHGWTGPSTRGRQGSRHEQ-AQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVD 3131
Query: 156 AQERQESHEQEVNREERL---------RSWEQEEEEEEVRAREPGMARGAESEWTWHGET 206
+ SH + R RS + EE + E + H +
Sbjct: 3132 SSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADI 3191
Query: 207 EGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTW 266
+ AV ++ G R QG + +++ +EG + E W
Sbjct: 3192 SRHSQAVQGQSEGSRRSRRQG-----SSVSQDSDSEGHSEDSE---------------RW 3231
Query: 267 GPGAEPEDWGIL---GREEARTTPGREEARAILDGEEARTI-SGGEEAETASGGEEAETA 322
A G + R +R E RA R+ SG AET+SGG+ A
Sbjct: 3232 SGSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQ----A 3287
Query: 323 SGGEEAGTASGGEEAG------IASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLG 376
+ E +S GE G S +G G +A +A W +SG + +D G
Sbjct: 3288 ASSHEQARSSPGERHGSRHQQSADSSRHSGIPRG--QASSAVRDSRHWGSSGSQASDSEG 3345
Query: 377 -VRQTEYGAVPGERLLEATGKVWVLEEEGDEEREA-----------EVSPFPKQPQVLGT 424
+++ +V G G +E +R +VS + G
Sbjct: 3346 HSEESDTQSVSGH---GQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGR 3402
Query: 425 ERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEE 484
RT + +A S EGQ +RG R R + E+
Sbjct: 3403 TRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSR----------RGRQGSHYEQ 3452
Query: 485 AQEERGSSRDPVAELPSDGEAE---GTADLEATPEARPEEELTGEESEAAQTSCGLLGVE 541
+ + G S + S G ++ G + + +E +G+ S + + +
Sbjct: 3453 SVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQ 3512
Query: 542 WGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAG 601
HS GQG G +T Q G + + E R +G
Sbjct: 3513 ADSSRHS-QSGQGQS--AGPRTSRNQ------------GSSVSQDSDSQGHSEDSERWSG 3557
Query: 602 SVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESEL 661
S RG+ QE + DG + AE R+S
Sbjct: 3558 SASRN-----------------HRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGT 3600
Query: 662 SEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEA 721
+ G A E+ +S E AD+ +G A +
Sbjct: 3601 HHAENSSG-----GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRD-- 3653
Query: 722 EADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGW 781
+ RG + ED+ T SV+A G PH
Sbjct: 3654 ----SGHRGSSGSQASDSEGHSEDSDTQSVSA---HGQAGPH------------------ 3688
Query: 782 DSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRV-EAEESAGA 840
+ +E+ G AG G GS +V+ Q E+ R G GGR E A
Sbjct: 3689 -QQSHQESTRGRSAG--RSGRSGSFLYQVSTH-EQSESAHGRAGPSTGGRQGSRHEQARD 3744
Query: 841 EDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHP 900
G T R GG + EQ D G G +H
Sbjct: 3745 SSRHSASQEGQDTIRGHPGS---RRGGRQGSY------------HEQSVDRSGHSGSHHS 3789
Query: 901 EGEAPRLLDAEGLMVTGGRRAEAKETEPE-----SLEHVRGQEEQPTHQAPAEAAPESVG 955
+ DA G R+ ++ET E H + + + QA + +S G
Sbjct: 3790 HTTSQGRSDAS--HGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQS-G 3846
Query: 956 EAETAEAMGSARGGAA---NSWSEA-PLPGSLLDVSVPRSRVHLSRSSSQRRSR--PSFR 1009
+ E+A + S R G++ +S SEA P S R+ SR S+ SR S
Sbjct: 3847 QGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSH 3906
Query: 1010 RTPAWEQQEEP 1020
R A Q P
Sbjct: 3907 RDTASHVQSSP 3917
Score = 42.7 bits (99), Expect = 0.002
Identities = 164/839 (19%), Positives = 282/839 (33%), Gaps = 149/839 (17%)
Query: 62 EAQEDLEGLRGSQNEGAG---RLRGPGDDRRHEVG----SSAVEQTWGWGDGSSHGSQAE 114
+A E R S E G +L+ R +G SSAV + G S S +E
Sbjct: 1989 QAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSE 2048
Query: 115 RQDSGAGETAKAARCQEPSAHLEARKKSKAG-SGACQDRSGQAQERQESHEQEVN----- 168
S +T + + H ++ K+S G SG RSG + +HEQ +
Sbjct: 2049 GH-SEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQS 2107
Query: 169 --------------REERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVG 214
++ R +E ++ +R PG +RG E G
Sbjct: 2108 APSTGGRQGSHYDQAQDSSRHSASQEGQDTIRG-HPGPSRGGRQ----GSHQEQSVDRSG 2162
Query: 215 PKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTW----GPGA 270
+ + QG +A G++ G+ A + + E++ + +R G+ A
Sbjct: 2163 HSGSHHSHTTSQGRSDASRGQS---GSRSASR--KTYDKEQSGDGSRHSGSHHHEASSWA 2217
Query: 271 EPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASG-------GEEAETAS 323
+ ++G+ ++ + P R +++ + E++E SG G E +
Sbjct: 2218 DSSRHSLVGQGQS-SGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSR 2276
Query: 324 GGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYG 383
G + + AG E+ SG A +SGG A +S ++ G R +
Sbjct: 2277 DGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAA--SSHEQARSSAGERHGSHH 2334
Query: 384 AVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQV--------LGTERTEEAAESQT 435
++ D R + + V G++ ++ S+
Sbjct: 2335 -----------------QQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSED 2377
Query: 436 AGREAVG--GQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSR 493
+ ++V GQ Q RG+ A G + E Q+E A G+
Sbjct: 2378 SDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHE--QSESAHGRTGT-- 2433
Query: 494 DPVAELPSDGEAEGTADLEATPEARPEEELTGEES---EAAQTSCGLLGVEW-------- 542
S G +G+ +A +R G+++ +S G G +
Sbjct: 2434 -------STGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSG 2486
Query: 543 -GGLTHSVTKGQG----PELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGP 597
G HS T QG G+++ ++Q E + E R+ +G
Sbjct: 2487 HSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGH 2546
Query: 598 RHAG---SVKPEASEAFPGAWENRT-----RKDMER----------GNTQEDAADGEQ-- 637
G S P S + ++ + +D ER G+ QE DG +
Sbjct: 2547 SQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHP 2606
Query: 638 REEEETAGGQTLAAEA---EGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQEL 694
R +E G +A++ G R ++ S +GG+ A E+ +S E
Sbjct: 2607 RSHQEDRAGHGHSADSSRQSGTRHTQTS----SGGQ------AASSHEQARSSAGERHGS 2656
Query: 695 DGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAA- 753
AD+ +G A + + RG+ + ED+ T SV+A
Sbjct: 2657 HHQQSADSSRHSGIGHGQASSAVRD------SGHRGYSGSQASDNEGHSEDSDTQSVSAH 2710
Query: 754 GIMGGDVVPH-ISAAGAGEALEGVLGQGWDSKEKEEAAAGEH--AGGQEFGLEGSAEEE 809
G G H SA G G G E + H G G +GS E+
Sbjct: 2711 GQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQ 2769
Score = 38.1 bits (87), Expect = 0.046
Identities = 102/463 (22%), Positives = 150/463 (32%), Gaps = 100/463 (21%)
Query: 597 PRHAGSVKPEAS-EAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEG 655
PR G + E+S E + T ++ E G +++ E+ + E T G +E
Sbjct: 144 PRETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSER 203
Query: 656 DRESELSE--VPEAGGEGLTTQD-------AGCGTEEGEAS------VSENQELDGSTGA 700
E E +E V + G TQ A T + EA + EN+ + S +
Sbjct: 204 LEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSS 263
Query: 701 DAGPCPSLGEAYARETEDEEAEADRT-SRRGWRLQAVAVGLPDREDAQ--TGSVAAGIMG 757
D + + T + RT RRG R+ ED++ +GS + G
Sbjct: 264 DGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHG 323
Query: 758 G-----------------DVVPHISAA------GAGEALEGVLGQGWDSKEKEEAAAGEH 794
D H +A G A GQ S E+ ++ GE
Sbjct: 324 SAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGER 383
Query: 795 AGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTA 854
G S+ TGRG A R G +A +S G ++ S T
Sbjct: 384 HGSGHQQSADSSRHSATGRGQASSAVSDR-GHRGSSGSQASDSEGHSEN-------SDTQ 435
Query: 855 RAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEG----------EA 904
G G G +++ +E + GR G+ E
Sbjct: 436 SVSGHG------------------KAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQ 477
Query: 905 PRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMG 964
P TGGR+ E +S H QE Q T + G
Sbjct: 478 PDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHP----------------G 521
Query: 965 SARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPS 1007
S+RGG S E + S S H S ++SQ RS S
Sbjct: 522 SSRGGRQGSHHEQSVNRS------GHSGSHHSHTTSQGRSDAS 558
Score = 33.5 bits (75), Expect = 1.1
Identities = 45/198 (22%), Positives = 82/198 (41%), Gaps = 20/198 (10%)
Query: 34 VPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRG-PGDDRRHEV 92
V T E+ A G G+ G E+A++ + EG +RG PG R
Sbjct: 3714 VSTHEQSESAHGRAGPSTGGRQGSR-HEQARDSSR--HSASQEGQDTIRGHPGSRRGGRQ 3770
Query: 93 GS---SAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGAC 149
GS +V+++ G SH + R D+ G++ SA E R + ++G G+
Sbjct: 3771 GSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSR------SASRETRNEEQSGDGS- 3823
Query: 150 QDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGE-TEG 208
R ++ + S + + +R + Q E R+R G + +S+ + E +E
Sbjct: 3824 --RHSGSRHHEASTQADSSRHSQS---GQGESAGSRRSRRQGSSVSQDSDSEAYPEDSER 3878
Query: 209 KAGAVGPKAAGDNREMEQ 226
++ + G +RE +
Sbjct: 3879 RSESASRNHHGSSREQSR 3896
>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
Length = 1530
Score = 67.0 bits (162), Expect = 9e-11
Identities = 165/661 (24%), Positives = 253/661 (38%), Gaps = 100/661 (15%)
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG---DEAW 364
E+ E A E G E G E G+ GE G+ G+ A + G DEA
Sbjct: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA- 875
Query: 365 TTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGT 424
+++A +L V +T+ A GE+ LE VL E A +V
Sbjct: 876 ---PEKQALMLTVLETDKAASEGEQGLEKA----VLANE------AAALNLEHLHEVAAL 922
Query: 425 ERTEEAAESQTAGREAVGGQEAGESFE-GQVDLRGKEAEMRQDLGIRADRARMEELVQAE 483
+ E + G AV + GES E +DL ++ +D + + E ++ E
Sbjct: 923 REAATSEEGEAEGGVAVS--DVGESEEEASIDL--EDTGPMEDTASKREDGSEEAILGGE 978
Query: 484 E-AQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEW 542
E A+E + R P GEAE A E PEE +E+ +
Sbjct: 979 EPAKERKEVMRTETRLSPFTGEAE--ASRMQVSEGSPEEGSLAKEAFLCKEDV------- 1029
Query: 543 GGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGS 602
+G E++ A+ ++ + +E EL LA + + ER + R S
Sbjct: 1030 ----------EGEEMVTEAEA-NREDDRKEILPKELD--LARERRKAERP-KTSLRKTDS 1075
Query: 603 VKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEET-AGGQTLAAEAEGDRESEL 661
+ E + A + K+ ++ +E + E R EEET A + ++AE + E
Sbjct: 1076 EREEVTRA-NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEA 1134
Query: 662 SEVPEAGGEGLTTQDAGCGTEEG--EASVSENQELDGSTGA-DAGPCPSLGEAYARETED 718
SE+ + GL +D+ T EA+ + L+ T G L EA E +D
Sbjct: 1135 SELSD--NPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKD 1192
Query: 719 EEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLG 778
E + R +R A+ R+D + G++AA P AG +A EG++
Sbjct: 1193 REELSSRENR--------ALKEGHRQDGE-GALAA--------PEAEPAGKVQAPEGLIP 1235
Query: 779 QGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESA 838
+ + EE AA +H GLEG AE G+G ++E AEE
Sbjct: 1236 A---TGQAEELAAKDHDSCA--GLEGRAE----GQGGVDVVLRTQEA-------VAEE-- 1277
Query: 839 GAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDY 898
DP ++ R E + E +K LE EA+ + E D EG
Sbjct: 1278 --------DPIMAEKFREEAVDEDPEEEE--DKECTLETEAMQDRNSEGDGDMEGEGNTQ 1327
Query: 899 HPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAE 958
EG + A ++ GG AE E E L EE+ A ++ V E E
Sbjct: 1328 KNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTI--ANKASSFSDVAEEE 1385
Query: 959 T 959
T
Sbjct: 1386 T 1386
Score = 55.1 bits (131), Expect = 4e-07
Identities = 155/633 (24%), Positives = 233/633 (36%), Gaps = 112/633 (17%)
Query: 39 REAQAAEE---LGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGD--------- 86
REA +EE G VAV G+ EEEA DLE ++ + R G +
Sbjct: 923 REAATSEEGEAEGGVAVSDVGES-EEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPA 981
Query: 87 DRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAA-----------RCQEPSAH 135
R EV + + G+ + Q G AK A E A+
Sbjct: 982 KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEAN 1041
Query: 136 LE-------------ARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEE 182
E AR++ KA +R + + +S +EV R L+ + +EE
Sbjct: 1042 REDDRKEILPKELDLARERRKA------ERPKTSLRKTDSEREEVTRANALKDEDAFKEE 1095
Query: 183 EEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAE 242
++++A E E+E E E KA P G + E E V ++ ++ PG
Sbjct: 1096 QKLKAEE------GETETEVRAEEETKA---PPNEMGSDAENEAPVEASEL--SDNPGLL 1144
Query: 243 GAGKGEEVVV--------VEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARA 294
G +E VV EK+ E+ A G G EAR T ++ R
Sbjct: 1145 GEDSLKETVVPIFEATPGFEKSLENITALRKEGGGER--------LSEARDTEHKD--RE 1194
Query: 295 ILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEA 354
L E R + G + GE A A E AG E A+G A+ ++
Sbjct: 1195 ELSSRENRALKEGHRQD----GEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDS 1250
Query: 355 GTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSP 414
G G+ D+ V +T+ + ++ + ++E+ +EE + E
Sbjct: 1251 CAGLEG----RAEGQGGVDV--VLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKEC-- 1302
Query: 415 FPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRA 474
T TE + + G + G+ + EG R E+ G A+ A
Sbjct: 1303 ---------TLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
Query: 475 RME-ELVQAEEAQEE-----RGSSRDPVAELPSDGEAEGTADLEATPEARPEEEL--TGE 526
E E++ E EE + SS VAE + + + A EEL +GE
Sbjct: 1354 AEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGE 1413
Query: 527 ESEAAQ----TSCGLLGVEWGGLTHSVTKGQGPELMGGA---QTPTKQPEER-EAGEVEL 578
E AA+ T GV G T G G E G+ + T + R E G E
Sbjct: 1414 EVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEK 1473
Query: 579 MGVLALSKE-EQERSLEAGPRHAG-SVKPEASE 609
L LS+E E+E S E+ A VKP+ +E
Sbjct: 1474 FR-LGLSREGERELSPESLQAMATLPVKPDFTE 1505
Score = 54.7 bits (130), Expect = 5e-07
Identities = 157/705 (22%), Positives = 262/705 (37%), Gaps = 107/705 (15%)
Query: 9 PGLHQALRGALDS-----LGTFVSYLLG-----DAVPTVEREAQAAEELGVVAVGKTGKI 58
PG+ + GA ++ LG S +G DAV + EA + L ++ V +T K
Sbjct: 833 PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQAL-MLTVLETDKA 891
Query: 59 VEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDS 118
E ++ LE + A L + HEV +A+ + +G + G A D
Sbjct: 892 ASE-GEQGLEKAVLANEAAALNL-----EHLHEV--AALREAATSEEGEAEGGVAV-SDV 942
Query: 119 GAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQ 178
G E + ++ + K + GS ++ +E + ++ + E RL +
Sbjct: 943 GESEEEASIDLEDTGPMEDTASKREDGS---EEAILGGEEPAKERKEVMRTETRLSPFTG 999
Query: 179 EEEEEEVRAREPGMARG--AESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGET 236
E E ++ E G A+ + + EG+ +A ++ E +E D
Sbjct: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARE 1059
Query: 237 EEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAIL 296
K E + +S R T + ED ++ + G E
Sbjct: 1060 RR-------KAERPKTSLRKTDSEREEVTRANALKDED-AFKEEQKLKAEEGETETEVRA 1111
Query: 297 DGE-EARTISGGEEAETASGGEEAETASG----GEEA--------GTASGGEEAGIASGG 343
+ E +A G +AE + E +E + GE++ A+ G E + +
Sbjct: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
Query: 344 EAGTASGGE---EAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVL 400
GGE EA D +S + A G RQ GA+ E GKV
Sbjct: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEA-EPAGKV--- 1227
Query: 401 EEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVD--LRG 458
+ P+ L T +A E ++ G E +G VD LR
Sbjct: 1228 ----------------QAPEGL-IPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRT 1270
Query: 459 KEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEAR 518
+EA +D I A++ R E + + E +E++ + + E D +EG D+E +
Sbjct: 1271 QEAVAEED-PIMAEKFREEAVDEDPEEEEDKECTLE--TEAMQDRNSEGDGDMEGEGNTQ 1327
Query: 519 PEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQP---------- 568
E + G A + G GG T + T + E++ G++T ++
Sbjct: 1328 KNEGMGGGRVVAVEVLHG------GGET-AETAAEEREVLAGSETAEEKTIANKASSFSD 1380
Query: 569 ---EEREAGEVELMGVLALSK----EEQERSLEAGP---RHAGSVKPEASEAFPGAWENR 618
EE + EL+G A + EE RS E P + EA PGA E +
Sbjct: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440
Query: 619 TR---KDMERGNTQEDAADGEQREEEETAGGQ--TLAAEAEGDRE 658
T ++ E G+ ++AA G +ET + L EG+RE
Sbjct: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE 1485
>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
Length = 819
Score = 65.5 bits (158), Expect = 3e-10
Identities = 175/857 (20%), Positives = 303/857 (35%), Gaps = 107/857 (12%)
Query: 30 LGDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRR 89
LG A+ E A ++ G + + L + + RLRG ++
Sbjct: 22 LGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRG----QK 77
Query: 90 HEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGAC 149
V Q W G+ ++ G GE AA A KS G G
Sbjct: 78 GAVAGKEARQHWQKAAGAGGA-----ENRGGGEQKAAA----------AGTKSLGGRGRK 122
Query: 150 QDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGK 209
R GQ S + R +S + A++ A G +S+ GE K
Sbjct: 123 PRRRGQKAAATGSKKP---RWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQG---GEKPQK 176
Query: 210 AGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPG 269
A A G K+ + +G + G+ ++ G + K TR G
Sbjct: 177 AAAAGAKSRSGKKPRRRGAKSR--GDEDKKGRQREAKSR--------FGKTRG-GRRKKH 225
Query: 270 AEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAG 329
P+ G ++R G++ + G++A T G + GG + + G+ A
Sbjct: 226 RRPKP--AAGGAKSRRGGGKKPQKQRRRGQKAAT-GGKSRVGKSRGGGDKKLRRQGQNAA 282
Query: 330 TASGGEEAGIASGGE--AGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPG 387
A G + G A+ GE A GG + G + W GK+ G + T+ A
Sbjct: 283 LA-GAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR-RRGQKATKAAAAGT 340
Query: 388 ERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAG 447
+R K V+ + +++ K+P+ ++ A G + G +EA
Sbjct: 341 KRGGGGQQKAAVVGVKSRKKQRRR----GKKPR---RQKASAAGAKSRGGGDKKGLREAK 393
Query: 448 ESFEGQVDLRGKEAEMRQDL---------GIRADRARMEELVQAEEAQEERGSSRDPVAE 498
+G+ R + R G + R R + ++ + G + P
Sbjct: 394 RRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRR 453
Query: 499 LPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELM 558
G+ EA E+R +++ +++ AA T G++ + +GQ E
Sbjct: 454 ----GQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA 509
Query: 559 GGAQTPT-------KQPEEREAGEVELMGVLALSKEEQ-ERSLEAGPRHAGSVKPEASEA 610
G T KQP ++ + SK Q ++++ AG G + S
Sbjct: 510 GEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSR- 568
Query: 611 FPGAWENRTRKDMERGNTQEDAADGEQREE-EETAGGQTLAAEAEGDRESELSEVPEAGG 669
G N+ R+ + + G+++ ++ A G T + +G +++ +A G
Sbjct: 569 --GGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQ---KAAG 623
Query: 670 EGLTTQDAGCGTEEGEASVSENQELDGSTGADAG--------PCPSLGEAYARETEDEEA 721
G ++ + +A+ +E G+T +G P + E+ A +EA
Sbjct: 624 TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEA 683
Query: 722 EADRTSR------RGWRLQAVAVGL-PDREDAQTGSVAAGIMGGDVVPHISAAGAGEALE 774
EA + R RG Q AVG+ P + + + GG + G+G A
Sbjct: 684 EARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGA----KSRGSGGAKS 739
Query: 775 GVLGQGWDSKEKEEAAAGEHAGGQEFGLEG------SAEEEVTGRGSQVEAFESREGGPW 828
G K+ AA+ H GG G S E+ VT G + A GG
Sbjct: 740 RGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAA----AGGKK 795
Query: 829 GGRVEAEESAGAEDSCG 845
RV++ G + + G
Sbjct: 796 PPRVKSRGGRGQKAAAG 812
Score = 32.3 bits (72), Expect = 2.5
Identities = 60/265 (22%), Positives = 100/265 (37%), Gaps = 34/265 (12%)
Query: 107 SSHGSQAERQDSGAG--------ETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQE 158
+SHG +Q G G +TA AA+ + +K A +G + RSG +
Sbjct: 557 TSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQK--AAAGVTKSRSGDGGK 614
Query: 159 RQESHEQE-VNREERLRSWEQEEEEEEVRAREPGMARGAESEWT------WH-----GET 206
+ + + R + W + +++ A E A GA S + W G
Sbjct: 615 KAWRQKAAGTGAKSRKKPWRRGQKD--AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSE 672
Query: 207 EGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTW 266
A AVG +A + R+ + R G+ + A G + + +S G
Sbjct: 673 SSAAAAVGQEA--EARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAK 730
Query: 267 GPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGG------EEAETASGGEEAE 320
G+ G ++R+ +++ G R GG E+A TA GG++A
Sbjct: 731 SRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTA-GGQKAA 789
Query: 321 TASGGEEAGTAS-GGEEAGIASGGE 344
A G + S GG A+GG+
Sbjct: 790 AAGGKKPPRVKSRGGRGQKAAAGGK 814
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 63.5 bits (153), Expect = 1e-09
Identities = 174/981 (17%), Positives = 302/981 (30%), Gaps = 128/981 (13%)
Query: 89 RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
RH S + G GS S RQ SG+G + R H + + +GSG
Sbjct: 1208 RHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGR 1267
Query: 149 CQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAR------EPGMARGAESEWTW 202
R E + H + E + + + G G S +
Sbjct: 1268 SSSRG--PYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQ 1325
Query: 203 HGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRA 262
G + G++ + G + +G ++ G A +G++ G G+G G + +
Sbjct: 1326 EGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGH-----------SSS 1374
Query: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETA 322
+G G G+ W ++ GR G + SG E++S +
Sbjct: 1375 YGQHGSGS---GWS--------SSSGRH-------GSGSGQSSGFGHHESSSW-----QS 1411
Query: 323 SGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEY 382
SG + G+ SG + G +G +S GE G++SG ++ G LG ++
Sbjct: 1412 SGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLG--HGQH 1469
Query: 383 GAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAG---RE 439
G+ G+ + G+ + + SP+ + E+ S ++G RE
Sbjct: 1470 GSGSGQSPSPSRGR-----HGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRE 1524
Query: 440 AVGGQEAG----------ESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEER 489
+ GQ +G S GQ ++ G + ++ + +
Sbjct: 1525 SRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHG-QHGSGSSQSS 1583
Query: 490 GSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSV 549
G R S G + + +P +G S + Q G LG G H
Sbjct: 1584 GYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSG-LGESSGFGHHES 1642
Query: 550 TKGQGPEL--------------MGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEA 595
+ GQ G+++ ER +S
Sbjct: 1643 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGH 1702
Query: 596 GPRHAGSVKPEA---------SEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
G + +GS + + + G + + + RG + + + E+ G
Sbjct: 1703 GRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSG 1762
Query: 647 QTLAAEAEGDRESELSEVPEAG---GEGLTTQDAGCGTEEGEA-----SVSENQELDGST 698
+ A G + G G+ T G T + + S S G
Sbjct: 1763 HSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQ 1822
Query: 699 GADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTG-SVAAGIMG 757
G+ +G PS G + + + S GW + G + + G ++
Sbjct: 1823 GSGSGQSPSRGR-HGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQS 1881
Query: 758 GDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQV 817
H S +G + E + S E+ + +G GS + G G Q
Sbjct: 1882 SGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSS-GSSSSYGQHGSGSRQSLGHG-QH 1939
Query: 818 EAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEE 877
+ + P GR +G+ S P GS + + G G
Sbjct: 1940 GSGSGQSPSPSRGR----HGSGSGQSSSYGPYGSGSGWSSSRGPYESGSG--------HS 1987
Query: 878 EAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQ 937
+G RE G+ Y G + G T G+ A +H
Sbjct: 1988 SGLG-----HRESRSGQSSGYGQHG------SSSGHSSTHGQHGSASGQSSSCGQHGASS 2036
Query: 938 EEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSR 997
+ +H + +S G G + G GS S R R
Sbjct: 2037 GQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRG------SGSRQSPSYGRHGSGSGR 2090
Query: 998 SSSQRRSRPSFRRTPAWEQQE 1018
SSS + P + + E
Sbjct: 2091 SSSSGQHGPGLGESSGFGHHE 2111
Score = 57.8 bits (138), Expect = 6e-08
Identities = 76/373 (20%), Positives = 134/373 (35%), Gaps = 52/373 (13%)
Query: 89 RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
RH S + + G GS S RQ SG+G + R S H + + +GSG
Sbjct: 2148 RHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGR 2207
Query: 149 CQDRSGQAQERQESHEQEVNREE------RLRSWEQEEEEEEVRAREPGMARGAESEWTW 202
R E + H + E S + G G S +
Sbjct: 2208 SSSRG--PYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQ 2265
Query: 203 HGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRA 262
G + G++ + G +G ++ G + + +G++ G G+G G + +
Sbjct: 2266 EGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGH-----------SSS 2314
Query: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETA 322
+G G G+ W ++ GR G + SG E++S +
Sbjct: 2315 YGQHGSGS---GWS--------SSSGRH-------GSGSGQSSGFGHHESSSW-----QS 2351
Query: 323 SGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEY 382
SG + G+ SG + G +G +S GE G++SG ++ G LG ++
Sbjct: 2352 SGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLG--HGQH 2409
Query: 383 GAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAG---RE 439
G+ G+ + G+ + + SP+ + E+ ++G RE
Sbjct: 2410 GSGSGQSPSPSRGR-----HGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRE 2464
Query: 440 AVGGQEAGESFEG 452
+ GQ +G G
Sbjct: 2465 SRSGQSSGYGQHG 2477
Score = 56.2 bits (134), Expect = 2e-07
Identities = 170/950 (17%), Positives = 290/950 (30%), Gaps = 124/950 (13%)
Query: 72 GSQNEGAGRLRGP--GDDRRHEV--GSSAVEQTWGW-GDGSSHGSQAERQDSGAGETAKA 126
GS + R G G R E SS + ++G G GS S RQ SG+G +
Sbjct: 719 GSSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSR 778
Query: 127 ARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVR 186
R S H + + +G+ +C G + + + + Q E
Sbjct: 779 VRHGSSSGHSSSHGQHGSGT-SCSSSCGHYE----------SGSGQASGFGQHESGSGQG 827
Query: 187 AREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGK 246
+ G A G S HG T G++ + G + + G E+ + G G+G
Sbjct: 828 YSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGS 887
Query: 247 GEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISG 306
G+ + G G G+ G+ + G R+ G SG
Sbjct: 888 GQ-----------SPGHGQRGSGS--------GQSPSYGRHGSGSGRSSSSGRHG---SG 925
Query: 307 GEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTT 366
++ + +SG + G+ SG + G +G +S E+ G++SG ++
Sbjct: 926 SGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQ 985
Query: 367 SGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTER 426
G LG ++G+ G+ + G+ + + P+ +
Sbjct: 986 HGSGSRQSLG--HGQHGSGSGQSPSPSRGR-----HGSGSGQSSSYGPYRSGSGWSSSRG 1038
Query: 427 TEEAAESQTAG---REAVGGQEAG----------ESFEGQVDLRGKEAEMRQDLGIRADR 473
E+ ++G RE+ GQ +G S GQ ++ G + +
Sbjct: 1039 PYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQ 1098
Query: 474 ARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQT 533
+ + + G R S G + + +P +G S + Q
Sbjct: 1099 SSSHG-QHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQH 1157
Query: 534 SCGLLGVEWGGLTHSVTKGQ-----------------GPELMGGAQTPTKQPEEREAGEV 576
G LG G H + GQ G Q+ + +G
Sbjct: 1158 GSG-LGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSS 1216
Query: 577 ELMGVLALSKEEQERSLEAGP---------RHAGSVKPEASEAFPGAWENRTRKDMERGN 627
G + G RH + +S G+ R+ RG
Sbjct: 1217 SHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRS---SSRGP 1273
Query: 628 TQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAG---GEGLTTQDAGCGTEEG 684
+ + + E+ G + A G + G G+ T G T +
Sbjct: 1274 YESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQS 1333
Query: 685 EA-----SVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVG 739
+ S S G GA +G PS G + + + S GW + G
Sbjct: 1334 SSYGHRGSGSSQSSGYGRHGAGSGQSPSRGR-HGSGSGHSSSYGQHGSGSGWSSSSGRHG 1392
Query: 740 LPDREDAQTG-SVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQ 798
+ + G ++ H S +G + E G + E
Sbjct: 1393 SGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYE-QHGSRSGQSSRGERHGSSSGSSS 1451
Query: 799 EFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEG 858
+G GS + G G Q + + P GR +G+ S P GS + +
Sbjct: 1452 SYGQHGSGSRQSLGHG-QHGSGSGQSPSPSRGR----HGSGSGQSSSYSPYGSGSGWSSS 1506
Query: 859 MGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGG 918
G E+G + G RE R G+ Y G + G T G
Sbjct: 1507 RGP-YESG---------SSHSSGLGHRESR---SGQSSGYGQHG------SSSGHSSTHG 1547
Query: 919 RRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
+ +H + +H + +S G G + G
Sbjct: 1548 QHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPG 1597
Score = 54.7 bits (130), Expect = 5e-07
Identities = 167/971 (17%), Positives = 290/971 (29%), Gaps = 118/971 (12%)
Query: 52 VGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGS 111
+G++ E+ G+G G G GS + + + G GSS S
Sbjct: 1631 LGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQH-----GSRSGQSSRGERHGSSSRS 1685
Query: 112 QAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSG----ACQDRSGQAQERQESHEQEV 167
+ G+G + ++ S ++ + + GSG + + G R S
Sbjct: 1686 SSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYE 1745
Query: 168 NREERLRSWEQEEEEEEVRAR---------------EPGMARGAESEWTWHGETEGKAGA 212
+R + Q E + + G G S + G + G++ +
Sbjct: 1746 SRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSS 1805
Query: 213 VGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEP 272
G +G ++ G + + +G++ G G+G G + ++G G G+
Sbjct: 1806 HGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGH-----------SSSYGQHGSGS-- 1852
Query: 273 EDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTAS 332
W R G ++ E + S G + G + G +G +S
Sbjct: 1853 -GW---SSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSS 1908
Query: 333 GGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLL- 391
GE+ G +SG + G + + G + + SG+ + G +G+ G+
Sbjct: 1909 RGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG----RHGSGSGQSSSY 1964
Query: 392 --EATGKVWVLE----EEGD---------EEREAEVSPFPKQPQVLGTERTEEAAESQTA 436
+G W E G E R + S + + G T +
Sbjct: 1965 GPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST-HGQHGSAS 2023
Query: 437 GREAVGGQEAGESFEGQVDLRGKEAE-MRQDLGIRADRARMEELVQAEEAQEERGSSRDP 495
G+ + GQ S GQ G+ Q G + + Q GS + P
Sbjct: 2024 GQSSSCGQHGASS--GQSSSHGQHGSGSSQSSGYGRQGSGSGQ--SPGHGQRGSGSRQSP 2079
Query: 496 VAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGP 555
G ++ + P ES + Q+S G HS GQ
Sbjct: 2080 SYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSS--YSQHGSGSGHSSGYGQHG 2137
Query: 556 ELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGP---------RHAGSVKPE 606
G Q+ + +G G + G RH
Sbjct: 2138 SRSG--QSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHS 2195
Query: 607 ASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPE 666
+S G+ R+ RG + + + E+ G + A G +
Sbjct: 2196 SSHGQHGSGSGRS---SSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ 2252
Query: 667 AG---GEGLTTQDAGCGTEEGEA-----SVSENQELDGSTGADAGPCPSLGEAYARETED 718
G G+ T G T + + S S G G+ +G PS G + +
Sbjct: 2253 HGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGR-HGSGSGH 2311
Query: 719 EEAEADRTSRRGWRLQAVAVGLPDREDAQTG-SVAAGIMGGDVVPHISAAGAGEALEGVL 777
+ S GW + G + + G ++ H S +G + E
Sbjct: 2312 SSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYE-QH 2370
Query: 778 GQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEES 837
G + E +G GS + G G Q + + P GR
Sbjct: 2371 GSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHG-QHGSGSGQSPSPSRGR----HG 2425
Query: 838 AGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGD 897
+G+ S P GS + + G G +G RE G+
Sbjct: 2426 SGSGQSSSYSPYGSGSGWSSSRGPYESGSG--------HSSGLG-----HRESRSGQSSG 2472
Query: 898 YHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEA 957
Y G + G T G+ +H + +H + +S G
Sbjct: 2473 YGQHG------SSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYG 2526
Query: 958 ETAEAMGSARG 968
G + G
Sbjct: 2527 RQGSGSGQSPG 2537
Score = 53.9 bits (128), Expect = 8e-07
Identities = 60/281 (21%), Positives = 105/281 (37%), Gaps = 30/281 (10%)
Query: 89 RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
RH S + G GS + SG+G++ +R + S ++ S GSG+
Sbjct: 2382 RHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGS 2441
Query: 149 CQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEG 208
S E H + E RS + + G + G S HG T G
Sbjct: 2442 GWSSSRGPYESGSGHSSGLGHRES-RSGQSSGYGQH------GSSSGHSSTHGQHGSTSG 2494
Query: 209 KAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGP 268
++ + G A + G + + ++ G +G+G G+ + G G
Sbjct: 2495 QSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQ-----------SPGHGQRGS 2543
Query: 269 GA-EPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEE 327
G+ + +G G R++ + + GE S G +S G+ + + G
Sbjct: 2544 GSRQSPSYGRHGSGSGRSSSSGQHGSGL--GE-----SSGFGHHESSSGQSSSYSQHGSG 2596
Query: 328 AGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSG 368
+G +SG + G +G +S GE G++SG + G
Sbjct: 2597 SGHSSGYGQ----HGSRSGQSSRGERHGSSSGSSSHYGQHG 2633
Score = 53.5 bits (127), Expect = 1e-06
Identities = 67/328 (20%), Positives = 106/328 (32%), Gaps = 55/328 (16%)
Query: 53 GKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDR-----RHEVGSSAVEQTWGWGDGS 107
G+ G + + D EG Q+ G RG G + RH GS G GS
Sbjct: 1311 GQHGSTSGQSSTFDQEGSSTGQSSSYGH-RGSGSSQSSGYGRHGAGSGQSPSRGRHGSGS 1369
Query: 108 SHGSQAERQDSGAGETAKAARCQEPSAHLEA----RKKSKAGSGACQDRSGQAQERQESH 163
H S + SG+G ++ + R S S SG Q SG S+
Sbjct: 1370 GHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHS--SSY 1427
Query: 164 EQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNRE 223
EQ +R G S HG + G + + G +G +
Sbjct: 1428 EQHGSRS------------------------GQSSRGERHGSSSGSSSSYGQHGSGSRQS 1463
Query: 224 MEQGVREADAGETEEP--GAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGRE 281
+ G + +G++ P G G+G G+ ++ P W
Sbjct: 1464 LGHGQHGSGSGQSPSPSRGRHGSGSGQS--------------SSYSPYGSGSGWS---SS 1506
Query: 282 EARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIAS 341
G + + E S G +S G + G +G +S + G +S
Sbjct: 1507 RGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASS 1566
Query: 342 GGEAGTASGGEEAGTASGGDEAWTTSGK 369
G + G + +SG + SG+
Sbjct: 1567 GQSSSHGQHGSGSSQSSGYGRQGSGSGQ 1594
Score = 51.6 bits (122), Expect = 4e-06
Identities = 71/339 (20%), Positives = 116/339 (34%), Gaps = 51/339 (15%)
Query: 53 GKTGKIVEEEAQEDLEGLRGSQNEGAGRL-RGPGDDRRHEVGSSAVEQTWGWG---DGSS 108
G+ G + + G SQ+ G GR G G H S Q+ +G GS
Sbjct: 2500 GQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSG 2559
Query: 109 HGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVN 168
S + + SG GE++ + S + + +GSG SG Q S +
Sbjct: 2560 RSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSG---HSSGYGQHGSRSGQSS-- 2614
Query: 169 REERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGV 228
R G + G+ S + HG ++ G + +G + +G
Sbjct: 2615 -----------------RGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGR 2657
Query: 229 READAGETEEPGAEGAGKGEEVV--VVEKACESTRAWGTWGPGAEPEDWGILGREEARTT 286
+ G + G G+G G E + +G G+ G A +
Sbjct: 2658 HGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGS--------GHSSAYSQ 2709
Query: 287 PGREEARAILDGEEARTI--SGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASG-- 342
G G+ T S + E +S G+ + G + +SG G SG
Sbjct: 2710 HGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQS 2769
Query: 343 ---GEAGTASG--------GEEAGTASGGDEAWTTSGKE 370
G G+ SG G +G +SG + + SG++
Sbjct: 2770 LSHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSGSGQD 2808
Score = 50.4 bits (119), Expect = 9e-06
Identities = 61/319 (19%), Positives = 105/319 (32%), Gaps = 58/319 (18%)
Query: 53 GKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQ 112
G++ + E+ RG G+G+ PG +R GS G GS S
Sbjct: 862 GQSSSYGQHESASHHASGRGRHGSGSGQ--SPGHGQRGS-GSGQSPSYGRHGSGSGRSSS 918
Query: 113 AERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREER 172
+ R SG+G+++ KS +G + + G S+EQ +R
Sbjct: 919 SGRHGSGSGQSSGFGH------------KSSSGQSSGYTQHGSGSGHSSSYEQHGSRS-- 964
Query: 173 LRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREAD 232
G S HG + G + + G +G + + G +
Sbjct: 965 ----------------------GQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG 1002
Query: 233 AGETEEP--GAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGRE 290
+G++ P G G+G G+ ++GP W G
Sbjct: 1003 SGQSPSPSRGRHGSGSGQS--------------SSYGPYRSGSGWS---SSRGPYESGSG 1045
Query: 291 EARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASG 350
+ + E S G +S G + G +G +S + G +SG +
Sbjct: 1046 HSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQH 1105
Query: 351 GEEAGTASGGDEAWTTSGK 369
G + +SG + SG+
Sbjct: 1106 GSGSSQSSGYGRQGSGSGQ 1124
Score = 50.1 bits (118), Expect = 1e-05
Identities = 163/944 (17%), Positives = 302/944 (31%), Gaps = 86/944 (9%)
Query: 73 SQNEGAGRLRGPGDDRRHEVGSSA-VEQTWGW-GDGSSHGSQAERQDSGAGETAKAARCQ 130
S G R R GSSA ++G G GS R SG+G++ +R +
Sbjct: 488 SSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGR 547
Query: 131 EPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREP 190
S ++ G G+ + S E H + +E RS + +
Sbjct: 548 HESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQES-RSGQSSGYGQH------ 600
Query: 191 GMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEV 250
G + G S HG T G++ + G A + G + + ++ G +G+G G+
Sbjct: 601 GSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSP 660
Query: 251 VVVEKACE--STRAWGTWGPGA--------------------------EPEDWGILGREE 282
+ + ++G G G+ + + G
Sbjct: 661 SRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGS 720
Query: 283 ARTTPGREEARAILDGEEARTISGGEEAETASG----GEEAETASGGEEAGTASGGEEAG 338
+ ++ R+ G+ +R+ G + +S G + +SG G+ SG +
Sbjct: 721 SHSSGYRKHGSR--SGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSR 778
Query: 339 IASGGEAGTAS--GGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPG-ERLLEATG 395
+ G +G +S G +GT+ SG +A G Q E G+ G + A+G
Sbjct: 779 VRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQAS--GFGQHESGSGQGYSQHGSASG 836
Query: 396 KVWVLEEEGDEEREAEVS-PFPKQPQVLGTERTEEAAESQTAGREAVG---GQEAGESFE 451
G ++ S + E+A +GR G GQ G
Sbjct: 837 HFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQR 896
Query: 452 GQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADL 511
G + R+ + + + SS + G G +
Sbjct: 897 GSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSS 956
Query: 512 EATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEER 571
+R + E+ ++ S G G S+ GQ G + +P++
Sbjct: 957 YEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGS 1016
Query: 572 EAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQED 631
+G+ G + S GP +GS + G E+R+ + G
Sbjct: 1017 GSGQSSSYGPY---RSGSGWSSSRGPYESGS----GHSSGLGHRESRSGQSSGYGQHGSS 1069
Query: 632 AADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSEN 691
+ + + GQ+ + G + S + G ++Q +G G + + S
Sbjct: 1070 SGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSG--SSQSSGYGRQGSGSGQSPG 1127
Query: 692 QELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLP-DREDAQTGS 750
G G+ + PS G + + R+S G + ++ +G
Sbjct: 1128 H---GQRGSGSRQSPSYGR--------HGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQ 1176
Query: 751 VAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEV 810
++ G H S G + G +G + + + H G G S+
Sbjct: 1177 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRG--ERHGSSSGSSSHYGQHGSGSRQSSGHGR 1234
Query: 811 TGRGSQVEAFESREGGPWG-GRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLL 869
G GS R G G + +G+ S P S++ + G G
Sbjct: 1235 QGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 1294
Query: 870 EKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPE 929
++ + + + Q + G+ + EG + G + G R
Sbjct: 1295 SAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEG------SSTGQSSSYGHRGSGSSQSSG 1348
Query: 930 SLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANS 973
H G + P+ + G + + GS G +++S
Sbjct: 1349 YGRHGAGSGQSPSRGRHGSGS----GHSSSYGQHGSGSGWSSSS 1388
Score = 49.7 bits (117), Expect = 2e-05
Identities = 71/329 (21%), Positives = 120/329 (36%), Gaps = 40/329 (12%)
Query: 69 GLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAAR 128
G GS++ + R G+ R GSS+ ++G HGS RQ G G +R
Sbjct: 258 GQHGSRSGQSSR----GERHRSSSGSSS---SYG-----QHGS-GSRQSLGHGRQGSGSR 304
Query: 129 CQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAR 188
Q PS H+ S S Q SG + H + + + + +
Sbjct: 305 -QSPS-HVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYS 362
Query: 189 EPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGE 248
+ G G S HG T G+A + G + + G E+ + + G +G G+
Sbjct: 363 KHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQ 422
Query: 249 EVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISG-G 307
+ G G G+ G+ + G R+ G +SG G
Sbjct: 423 -----------SPGHGQRGSGS--------GQSPSSGQHGTGFGRSSSSGPY---VSGSG 460
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTS 367
+ +E +SG + G+ SG G +G +S GE G+++G ++
Sbjct: 461 YSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQH 520
Query: 368 GKEEADLLGVRQTEYGAVPGERLLEATGK 396
G LG + +G+ G+ + G+
Sbjct: 521 GSGSRQSLG--HSRHGSGSGQSPSPSRGR 547
Score = 49.7 bits (117), Expect = 2e-05
Identities = 62/307 (20%), Positives = 114/307 (37%), Gaps = 32/307 (10%)
Query: 72 GSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQE 131
G G+G+ G G SS Q G GS H S E+ S +G++++ R
Sbjct: 1389 GRHGSGSGQSSGFGHHESSSWQSSGCTQH---GSGSGHSSSYEQHGSRSGQSSRGER--- 1442
Query: 132 PSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPG 191
S +GS + + G + H Q + + S R R G
Sbjct: 1443 --------HGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPS--------PSRGRH-G 1485
Query: 192 MARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVV 251
G S ++ +G G + + GP +G + G RE+ +G++ G G+ G
Sbjct: 1486 SGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSST 1545
Query: 252 VVEKACESTRAWGTWGPGAEPEDWGILGREEARTTP----GREEARAILDGEEARTISGG 307
+ S ++ GA G+ + ++ GR+ + + + SG
Sbjct: 1546 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGS 1605
Query: 308 EEAET-----ASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDE 362
++ + + G + + G G +SG +SG + + G +G +SG +
Sbjct: 1606 RQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ 1665
Query: 363 AWTTSGK 369
+ SG+
Sbjct: 1666 HGSRSGQ 1672
Score = 46.6 bits (109), Expect = 1e-04
Identities = 176/940 (18%), Positives = 298/940 (31%), Gaps = 113/940 (12%)
Query: 72 GSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQE 131
G QN + + G G GS G GS S + SG+G+++ ++ +
Sbjct: 180 GEQNSDSHQSSGRGQCGS---GSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKS 236
Query: 132 PSAHLEARKKSKAGSGACQ------DRSGQAQERQESHEQEVNREERLRSWEQEEEEEEV 185
S + +GSG RSGQ+ R E H +
Sbjct: 237 SSGQSSGYSQHGSGSGHSSGYGQHGSRSGQS-SRGERHRSSSGSSSSYGQHGSGSRQSLG 295
Query: 186 RAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAG 245
R+ +R + S HG G + + G +G + +G E+ +G+T G +G
Sbjct: 296 HGRQGSGSRQSPSH-VRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESG 354
Query: 246 KGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTIS 305
G + + S G+ ++ + G+ + G ++ G+
Sbjct: 355 SG------QSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQH----- 403
Query: 306 GGEEAETASGGEEAETASGGEEAGTASGGEEAGIA-SGGEAGTASGGEEAG--TASGGDE 362
E A S G ++ G+ G G +G + S G+ GT G + SG
Sbjct: 404 --ESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGY 461
Query: 363 AWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVL 422
+ E + T++G+ G ++G G R
Sbjct: 462 SSGFGHHESSSEHSSGYTQHGSGSG----HSSGHGQHGSRSGQSSR-------------- 503
Query: 423 GTERTEEAAESQTAGREAVGG-QEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQ 481
G + A S + G+ G Q G S G G G +R
Sbjct: 504 GERQGSSAGSSSSYGQHGSGSRQSLGHSRHGS----GSGQSPSPSRGRHESGSRQSSSYG 559
Query: 482 AEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQT-------- 533
R SSR P G + G E+ G S + T
Sbjct: 560 PHGYGSGRSSSRGPYES--GSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTS 617
Query: 534 ----SCGLLGVEWG--------GLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGV 581
SCG G G G S + G + G Q+P++ + G G
Sbjct: 618 GQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYG- 676
Query: 582 LALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQR--E 639
S GP GSV ++S + +++ G +Q +
Sbjct: 677 --QHGSGSGWSSSNGPH--GSVSGQSS-----GFGHKSGSGQSSGYSQHGSGSSHSSGYR 727
Query: 640 EEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTG 699
+ + GQ+ +E G S LS G G + Q +G G + + S ++ GS+
Sbjct: 728 KHGSRSGQSSRSEQHGS-SSGLSSSYGQHGSG-SHQSSGHGRQGSGSGHSPSRVRHGSSS 785
Query: 700 ADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLP-DREDAQTGSVAAGIMGG 758
+ G + + E+ G+ G + + +G ++ G
Sbjct: 786 GHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHG 845
Query: 759 DVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVE 818
S++G ++ G S + +A HA G+ G GS + G G
Sbjct: 846 STSGQSSSSGQHDS-----SSGQSSSYGQHESASHHASGR--GRHGSGSGQSPGHG---- 894
Query: 819 AFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEE 878
R G +G+ S GS + ++ G G + G +T
Sbjct: 895 ---QRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHK-SSSGQSSGYTQHGSG 950
Query: 879 AVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQE 938
+ EQ G+ G + + G +G R +SL H GQ
Sbjct: 951 SGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSR---------QSLGH--GQH 999
Query: 939 EQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAP 978
+ Q+P+ + + + + G R G+ S S P
Sbjct: 1000 GSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGP 1039
Score = 44.3 bits (103), Expect = 6e-04
Identities = 63/310 (20%), Positives = 103/310 (33%), Gaps = 43/310 (13%)
Query: 72 GSQNEGAGRLRGPGDDR-RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQ 130
G G+G + P R RH GS +G GS S +SG+G ++
Sbjct: 2405 GHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLG--- 2461
Query: 131 EPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREP 190
H E+R +G G + G + +H Q + + S Q
Sbjct: 2462 ----HRESRSGQSSGYG----QHGSSSGHSSTHGQHGSTSGQSSSCGQH----------- 2502
Query: 191 GMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEV 250
G + G S HG ++ G + +G + G R + + ++ G G+G G
Sbjct: 2503 GASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGR-- 2560
Query: 251 VVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEA 310
+ + G G G E G E + G + G +
Sbjct: 2561 ---------SSSSGQHGSGLG-ESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRS 2610
Query: 311 ETASGGEEAETASG--------GEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDE 362
+S GE ++SG G + +SG G SG G G +S +
Sbjct: 2611 GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQ 2670
Query: 363 AWTTSGKEEA 372
+ SG+ +
Sbjct: 2671 HGSGSGRSSS 2680
Score = 33.5 bits (75), Expect = 1.1
Identities = 44/230 (19%), Positives = 87/230 (37%), Gaps = 56/230 (24%)
Query: 150 QDRSGQAQERQESHEQEVNREERLR----SWEQEEEEEEVRAREPGMARGAES---EWTW 202
+D + Q QE QE E+E N+ + SW E + R + G ES ++
Sbjct: 102 RDDTHQHQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSF 161
Query: 203 HGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRA 262
+ G+ + +++ G + +D+ ++ G G+G G+ +
Sbjct: 162 QRDFSGQHNSYSGQSSS------YGEQNSDSHQSSGRGQCGSGSGQ-----------SPN 204
Query: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETA 322
+G G G+ G+ + + G + +SG + +++
Sbjct: 205 YGQHGSGS---------------------------GQSSSNDTHGSGSGQSSGFSQHKSS 237
Query: 323 SGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEA 372
SG +SG + G SG +G G +G +S G+ ++SG +
Sbjct: 238 SG-----QSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSS 282
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 63.5 bits (153), Expect = 1e-09
Identities = 169/816 (20%), Positives = 278/816 (34%), Gaps = 136/816 (16%)
Query: 183 EEVRAREPGMARGAESEWTWHGETEGKAGAVGP-KAAGDNREMEQGVREADAGETEEP-G 240
+E AR+ A G + T + K GA+ P K A E + E E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVT----PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
K E ++ +A S A GT G GA P G G ++T G+ E D E
Sbjct: 287 TRSQVKASEKILQVRAA-SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSES 341
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
+ S E ET + + + G+ + + A + A A G+ +G
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGP 396
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
A +GK E D + E + +EE A+ P K PQ
Sbjct: 397 AVAKAQAGKREEDSQSSSE---------------------ESDSEEEAPAQAKPSGKAPQ 435
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
V + A ES G ++ G + QV + GK+ E
Sbjct: 436 VRAA--SAPAKESPRKGAAPAPPRKTGPA-AAQVQV-GKQEE------------------ 473
Query: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
+ + EE S R+ +A + A L +P+ +P A+ G LG
Sbjct: 474 DSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG- 518
Query: 541 EWGGLTHSVTKGQGPELMG--GAQTPTKQ------------PEEREAGEVELMGVLALSK 586
KG GP G G TP+ Q E ++ + E+ +A ++
Sbjct: 519 ----------KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 568
Query: 587 EEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
E+ ++ + K +A P A + + K M+ + E+++D EE A
Sbjct: 569 EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA-- 626
Query: 647 QTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCP 706
AA+A+ ++P+ T ++ G+ + AG P
Sbjct: 627 -MTAAQAK-----PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 707 SLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHIS 765
++ R ED + + S AV VG Q SV G+ + VP
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKG 733
Query: 766 AAGAGEA--LEGVLG---------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------ 808
+ G G A L G G + DS+ EE + E A ++ S ++
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 809 EVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGL 868
R + S G +A++ + ++ + + T A G ++ G
Sbjct: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
Query: 869 L----EKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
+ + T EE++ +E E+ P G+ ++ A R+ A
Sbjct: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AA 912
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
T P Q + + +S GEA A
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Score = 48.5 bits (114), Expect = 3e-05
Identities = 110/520 (21%), Positives = 177/520 (34%), Gaps = 111/520 (21%)
Query: 585 SKEEQERSLE---AGPRHAGSVKPEASEAFPGAWENRTRKDMER----GNTQEDAADGEQ 637
S+EE+E E A PR A + P + + + + + E+ GN+ A G+
Sbjct: 88 SEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 638 ----------REEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEAS 687
R+ E + TL +E E E + A G+ + + E +S
Sbjct: 148 VANLLSGKSPRKSAEPSANTTLVSETE--EEGSVPAFGAAAKPGMVSAGQADSSSEDTSS 205
Query: 688 VSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQ 747
S+ +++G PS+ A + + E+ A+
Sbjct: 206 SSDETDVEGK--------PSVKPAQVKASSVSTKESP---------------------AR 236
Query: 748 TGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAE 807
+ A G +G DV P + G L +K+ EE + G + S E
Sbjct: 237 KAAPAPGKVG-DVTPQVKG--------GALPPAKRAKKPEEESESSEEGSE------SEE 281
Query: 808 EEVTGRGSQVEAFES----------REGGPWGGRVEAEES-AGA---EDSCGLDPAGSQT 853
E G SQV+A E +G P G A AGA + G S++
Sbjct: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
Query: 854 ARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGL 913
+ E + E LL+ +A G + Q + + +G AP G
Sbjct: 342 SSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPPGKTGP 396
Query: 914 MVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANS 973
V + + +E S E +EE P P+ AP+ A +A A S R GAA
Sbjct: 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRKGAA-- 452
Query: 974 WSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAP 1033
P ++V + + RS EE + ++A
Sbjct: 453 ------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALAAMNAA 495
Query: 1034 EQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
+ +PL ++P+ G PLG G G PG
Sbjct: 496 QVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 527
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 63.5 bits (153), Expect = 1e-09
Identities = 169/816 (20%), Positives = 278/816 (34%), Gaps = 136/816 (16%)
Query: 183 EEVRAREPGMARGAESEWTWHGETEGKAGAVGP-KAAGDNREMEQGVREADAGETEEP-G 240
+E AR+ A G + T + K GA+ P K A E + E E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVT----PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
K E ++ +A S A GT G GA P G G ++T G+ E D E
Sbjct: 287 TRSQVKASEKILQVRAA-SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSES 341
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
+ S E ET + + + G+ + + A + A A G+ +G
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGP 396
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
A +GK E D + E + +EE A+ P K PQ
Sbjct: 397 AVAKAQAGKREEDSQSSSE---------------------ESDSEEEAPAQAKPSGKAPQ 435
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
V + A ES G ++ G + QV + GK+ E
Sbjct: 436 VRAA--SAPAKESPRKGAAPAPPRKTGPA-AAQVQV-GKQEE------------------ 473
Query: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
+ + EE S R+ +A + A L +P+ +P A+ G LG
Sbjct: 474 DSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG- 518
Query: 541 EWGGLTHSVTKGQGPELMG--GAQTPTKQ------------PEEREAGEVELMGVLALSK 586
KG GP G G TP+ Q E ++ + E+ +A ++
Sbjct: 519 ----------KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 568
Query: 587 EEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
E+ ++ + K +A P A + + K M+ + E+++D EE A
Sbjct: 569 EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA-- 626
Query: 647 QTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCP 706
AA+A+ ++P+ T ++ G+ + AG P
Sbjct: 627 -MTAAQAK-----PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 707 SLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHIS 765
++ R ED + + S AV VG Q SV G+ + VP
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKG 733
Query: 766 AAGAGEA--LEGVLG---------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------ 808
+ G G A L G G + DS+ EE + E A ++ S ++
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 809 EVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGL 868
R + S G +A++ + ++ + + T A G ++ G
Sbjct: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
Query: 869 L----EKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
+ + T EE++ +E E+ P G+ ++ A R+ A
Sbjct: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AA 912
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
T P Q + + +S GEA A
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Score = 48.5 bits (114), Expect = 3e-05
Identities = 110/520 (21%), Positives = 177/520 (34%), Gaps = 111/520 (21%)
Query: 585 SKEEQERSLE---AGPRHAGSVKPEASEAFPGAWENRTRKDMER----GNTQEDAADGEQ 637
S+EE+E E A PR A + P + + + + + E+ GN+ A G+
Sbjct: 88 SEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 638 ----------REEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEAS 687
R+ E + TL +E E E + A G+ + + E +S
Sbjct: 148 VANLLSGKSPRKSAEPSANTTLVSETE--EEGSVPAFGAAAKPGMVSAGQADSSSEDTSS 205
Query: 688 VSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQ 747
S+ +++G PS+ A + + E+ A+
Sbjct: 206 SSDETDVEGK--------PSVKPAQVKASSVSTKESP---------------------AR 236
Query: 748 TGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAE 807
+ A G +G DV P + G L +K+ EE + G + S E
Sbjct: 237 KAAPAPGKVG-DVTPQVKG--------GALPPAKRAKKPEEESESSEEGSE------SEE 281
Query: 808 EEVTGRGSQVEAFES----------REGGPWGGRVEAEES-AGA---EDSCGLDPAGSQT 853
E G SQV+A E +G P G A AGA + G S++
Sbjct: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
Query: 854 ARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGL 913
+ E + E LL+ +A G + Q + + +G AP G
Sbjct: 342 SSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPPGKTGP 396
Query: 914 MVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANS 973
V + + +E S E +EE P P+ AP+ A +A A S R GAA
Sbjct: 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRKGAA-- 452
Query: 974 WSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAP 1033
P ++V + + RS EE + ++A
Sbjct: 453 ------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALAAMNAA 495
Query: 1034 EQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
+ +PL ++P+ G PLG G G PG
Sbjct: 496 QVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 527
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 63.5 bits (153), Expect = 1e-09
Identities = 169/816 (20%), Positives = 278/816 (34%), Gaps = 136/816 (16%)
Query: 183 EEVRAREPGMARGAESEWTWHGETEGKAGAVGP-KAAGDNREMEQGVREADAGETEEP-G 240
+E AR+ A G + T + K GA+ P K A E + E E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVT----PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
K E ++ +A S A GT G GA P G G ++T G+ E D E
Sbjct: 287 TRSQVKASEKILQVRAA-SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSES 341
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
+ S E ET + + + G+ + + A + A A G+ +G
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGP 396
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
A +GK E D + E + +EE A+ P K PQ
Sbjct: 397 AVAKAQAGKREEDSQSSSE---------------------ESDSEEEAPAQAKPSGKAPQ 435
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
V + A ES G ++ G + QV + GK+ E
Sbjct: 436 VRAA--SAPAKESPRKGAAPAPPRKTGPA-AAQVQV-GKQEE------------------ 473
Query: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
+ + EE S R+ +A + A L +P+ +P A+ G LG
Sbjct: 474 DSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG- 518
Query: 541 EWGGLTHSVTKGQGPELMG--GAQTPTKQ------------PEEREAGEVELMGVLALSK 586
KG GP G G TP+ Q E ++ + E+ +A ++
Sbjct: 519 ----------KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 568
Query: 587 EEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
E+ ++ + K +A P A + + K M+ + E+++D EE A
Sbjct: 569 EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA-- 626
Query: 647 QTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCP 706
AA+A+ ++P+ T ++ G+ + AG P
Sbjct: 627 -MTAAQAK-----PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 707 SLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHIS 765
++ R ED + + S AV VG Q SV G+ + VP
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKG 733
Query: 766 AAGAGEA--LEGVLG---------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------ 808
+ G G A L G G + DS+ EE + E A ++ S ++
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 809 EVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGL 868
R + S G +A++ + ++ + + T A G ++ G
Sbjct: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
Query: 869 L----EKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
+ + T EE++ +E E+ P G+ ++ A R+ A
Sbjct: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AA 912
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
T P Q + + +S GEA A
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Score = 48.5 bits (114), Expect = 3e-05
Identities = 110/520 (21%), Positives = 177/520 (34%), Gaps = 111/520 (21%)
Query: 585 SKEEQERSLE---AGPRHAGSVKPEASEAFPGAWENRTRKDMER----GNTQEDAADGEQ 637
S+EE+E E A PR A + P + + + + + E+ GN+ A G+
Sbjct: 88 SEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 638 ----------REEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEAS 687
R+ E + TL +E E E + A G+ + + E +S
Sbjct: 148 VANLLSGKSPRKSAEPSANTTLVSETE--EEGSVPAFGAAAKPGMVSAGQADSSSEDTSS 205
Query: 688 VSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQ 747
S+ +++G PS+ A + + E+ A+
Sbjct: 206 SSDETDVEGK--------PSVKPAQVKASSVSTKESP---------------------AR 236
Query: 748 TGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAE 807
+ A G +G DV P + G L +K+ EE + G + S E
Sbjct: 237 KAAPAPGKVG-DVTPQVKG--------GALPPAKRAKKPEEESESSEEGSE------SEE 281
Query: 808 EEVTGRGSQVEAFES----------REGGPWGGRVEAEES-AGA---EDSCGLDPAGSQT 853
E G SQV+A E +G P G A AGA + G S++
Sbjct: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
Query: 854 ARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGL 913
+ E + E LL+ +A G + Q + + +G AP G
Sbjct: 342 SSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPPGKTGP 396
Query: 914 MVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANS 973
V + + +E S E +EE P P+ AP+ A +A A S R GAA
Sbjct: 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRKGAA-- 452
Query: 974 WSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAP 1033
P ++V + + RS EE + ++A
Sbjct: 453 ------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALAAMNAA 495
Query: 1034 EQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
+ +PL ++P+ G PLG G G PG
Sbjct: 496 QVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 527
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 63.5 bits (153), Expect = 1e-09
Identities = 169/816 (20%), Positives = 278/816 (34%), Gaps = 136/816 (16%)
Query: 183 EEVRAREPGMARGAESEWTWHGETEGKAGAVGP-KAAGDNREMEQGVREADAGETEEP-G 240
+E AR+ A G + T + K GA+ P K A E + E E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVT----PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
K E ++ +A S A GT G GA P G G ++T G+ E D E
Sbjct: 287 TRSQVKASEKILQVRAA-SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSES 341
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
+ S E ET + + + G+ + + A + A A G+ +G
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGP 396
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
A +GK E D + E + +EE A+ P K PQ
Sbjct: 397 AVAKAQAGKREEDSQSSSE---------------------ESDSEEEAPAQAKPSGKAPQ 435
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
V + A ES G ++ G + QV + GK+ E
Sbjct: 436 VRAA--SAPAKESPRKGAAPAPPRKTGPA-AAQVQV-GKQEE------------------ 473
Query: 481 QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV 540
+ + EE S R+ +A + A L +P+ +P A+ G LG
Sbjct: 474 DSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG- 518
Query: 541 EWGGLTHSVTKGQGPELMG--GAQTPTKQ------------PEEREAGEVELMGVLALSK 586
KG GP G G TP+ Q E ++ + E+ +A ++
Sbjct: 519 ----------KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 568
Query: 587 EEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
E+ ++ + K +A P A + + K M+ + E+++D EE A
Sbjct: 569 EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA-- 626
Query: 647 QTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCP 706
AA+A+ ++P+ T ++ G+ + AG P
Sbjct: 627 -MTAAQAK-----PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP 680
Query: 707 SLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHIS 765
++ R ED + + S AV VG Q SV G+ + VP
Sbjct: 681 AVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKG 733
Query: 766 AAGAGEA--LEGVLG---------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------ 808
+ G G A L G G + DS+ EE + E A ++ S ++
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 809 EVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGL 868
R + S G +A++ + ++ + + T A G ++ G
Sbjct: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
Query: 869 L----EKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
+ + T EE++ +E E+ P G+ ++ A R+ A
Sbjct: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AA 912
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETA 960
T P Q + + +S GEA A
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAA 948
Score = 48.5 bits (114), Expect = 3e-05
Identities = 110/520 (21%), Positives = 177/520 (34%), Gaps = 111/520 (21%)
Query: 585 SKEEQERSLE---AGPRHAGSVKPEASEAFPGAWENRTRKDMER----GNTQEDAADGEQ 637
S+EE+E E A PR A + P + + + + + E+ GN+ A G+
Sbjct: 88 SEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 638 ----------REEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEAS 687
R+ E + TL +E E E + A G+ + + E +S
Sbjct: 148 VANLLSGKSPRKSAEPSANTTLVSETE--EEGSVPAFGAAAKPGMVSAGQADSSSEDTSS 205
Query: 688 VSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQ 747
S+ +++G PS+ A + + E+ A+
Sbjct: 206 SSDETDVEGK--------PSVKPAQVKASSVSTKESP---------------------AR 236
Query: 748 TGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAE 807
+ A G +G DV P + G L +K+ EE + G + S E
Sbjct: 237 KAAPAPGKVG-DVTPQVKG--------GALPPAKRAKKPEEESESSEEGSE------SEE 281
Query: 808 EEVTGRGSQVEAFES----------REGGPWGGRVEAEES-AGA---EDSCGLDPAGSQT 853
E G SQV+A E +G P G A AGA + G S++
Sbjct: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
Query: 854 ARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGL 913
+ E + E LL+ +A G + Q + + +G AP G
Sbjct: 342 SSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPPGKTGP 396
Query: 914 MVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANS 973
V + + +E S E +EE P P+ AP+ A +A A S R GAA
Sbjct: 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRKGAA-- 452
Query: 974 WSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAP 1033
P ++V + + RS EE + ++A
Sbjct: 453 ------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALAAMNAA 495
Query: 1034 EQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
+ +PL ++P+ G PLG G G PG
Sbjct: 496 QVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 527
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 63.2 bits (152), Expect = 1e-09
Identities = 181/894 (20%), Positives = 319/894 (35%), Gaps = 129/894 (14%)
Query: 111 SQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNRE 170
++A Q +G+T++ P+ + + A G +AQ + + + + E
Sbjct: 279 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 338
Query: 171 ERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGP--KAAGDNREMEQGV 228
E EEE +A+ G A + E+ K A P K +++ G
Sbjct: 339 E-----SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 393
Query: 229 READAGETEEPG-----AEGAGKGEEVVVVEKACE----STRAWGTWGPGAEPEDWGILG 279
+E D+ + E A A +V + K+ + ST G G GA P G +G
Sbjct: 394 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 453
Query: 280 REEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGI 339
G+ E + EE+ S GE + +E + + T+S +
Sbjct: 454 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 513
Query: 340 ASGGEAGTASGGEEAGTASGGDEAWTTSGKEEA----------DLLGVRQTEYGAVPGER 389
+G A + + +E+ ++ EEA L + QT+ A P +
Sbjct: 514 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK--ACPKKT 571
Query: 390 LLEATGKVWVLEEEGDEEREA--EVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAG 447
A+ KV + R+A SP P V G T+ AE ++ E+ ++
Sbjct: 572 NTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG--GTQRPAEDSSSSEES----DSE 625
Query: 448 ESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEG 507
E G G+ + + L ++A ++ + A G + V ++ +AE
Sbjct: 626 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV----KAEK 681
Query: 508 TADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQ 567
D E++ EEE EE+ A+ + SV K Q A+ P+ +
Sbjct: 682 QEDSESS-----EEESDSEEAAASPAQ----------VKTSVKKTQAKANPAAARAPSAK 726
Query: 568 PEEREAGEVELMGVLALSKEEQERSLEAGP------------RHAGSVKPEASEAFPGAW 615
G+V V A ++ +Q + P R SV P +A A
Sbjct: 727 GTISAPGKV----VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 781
Query: 616 ENRTRKDMERGNTQEDAADGEQRE--EEETAGGQT------LAAEAEGDRESELSEVPEA 667
+ +T + + G+++E++ E+ E + G+T LA E R+ P
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841
Query: 668 GGEGLTTQDAGCGTEEGEASVSENQELDGSTGA--------------------DAGPCPS 707
G A G ++ S SE + DG A AGP +
Sbjct: 842 TGPSA----AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 897
Query: 708 LGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDRE----DAQTGSVAAGIMGGDVVPH 763
+A A T + ++ T+R +P + +T V + P
Sbjct: 898 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 957
Query: 764 ISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESR 823
S AGA + E + D K++E A + + A +T +V A ++
Sbjct: 958 ASMAGASSSKES--SRISDGKKQEGPAT-------QVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 824 EGGPWGGRVEAEESAGAEDSCGLDPA---GSQTARAEGMGAMVEAGGLLEKWTLLEEEAV 880
E P R + S+G + + G PA S + +A+G + + K +++
Sbjct: 1009 EAQPPVAR--TQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRK-----PKLPEVQQATK 1061
Query: 881 GWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAE--AKETEPESLE 932
+ + EDS +GE P+ + + R E +ET ES E
Sbjct: 1062 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSE 1115
Score = 58.5 bits (140), Expect = 3e-08
Identities = 180/920 (19%), Positives = 305/920 (33%), Gaps = 152/920 (16%)
Query: 85 GDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKA 144
G R+ E ++ + D S +E ++ ETAKA + L + S
Sbjct: 60 GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKA------TPRLASTNSSVL 113
Query: 145 GSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHG 204
G+ +A+ E + N + + ++ A +
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 205 ETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACE------ 258
E EG A G A + G+ AG+ + + + +E V KA E
Sbjct: 174 EEEGSVPAFGAAA-------KPGM--VSAGQADSSSEDTSSSSDETDVEVKASEKILQVR 224
Query: 259 --STRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGG 316
S A GT G GA P G G ++T G+ E D E + S E ET +
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAK 280
Query: 317 EEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLG 376
+ + G+ + + A + A A G+ +G A +GK E D
Sbjct: 281 ALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGPAVAKAQAGKREEDSQS 335
Query: 377 VRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTA 436
+ E + +EE A+ P K PQV + A ES
Sbjct: 336 SSE---------------------ESDSEEEAPAQAKPSGKAPQVRAA--SAPAKESPRK 372
Query: 437 GREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPV 496
G ++ G + QV + GK+ E + + EE S R+ +
Sbjct: 373 GAAPAPPRKTGPA-AAQVQV-GKQEE------------------DSRSSSEESDSDREAL 412
Query: 497 AELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPE 556
A + A L +P+ +P A+ G LG KG GP
Sbjct: 413 AAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG-----------KGAGPV 447
Query: 557 LMG--GAQTPTKQ------------PEEREAGEVELMGVLALSKEEQERSLEAGPRHAGS 602
G G TP+ Q E ++ + E+ +A ++E+ ++ +
Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 507
Query: 603 VKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELS 662
K +A P A + + K M+ + E+++D EE A AA+A+
Sbjct: 508 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAK-----PAL 559
Query: 663 EVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAE 722
++P+ T ++ G+ + AG P++ R ED +
Sbjct: 560 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS 619
Query: 723 ADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHISAAGAGEA--LEGVLG- 778
+ S AV VG Q SV G+ + VP + G G A L G G
Sbjct: 620 EESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 672
Query: 779 --------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------EVTGRGSQVEAFESRE 824
+ DS+ EE + E A ++ S ++ R + S
Sbjct: 673 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 732
Query: 825 GGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLL----EKWTLLEEEAV 880
G +A++ + ++ + + T A G ++ G + + T EE++
Sbjct: 733 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 792
Query: 881 GWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQ 940
+E E+ P G+ ++ A R+ A T P Q +
Sbjct: 793 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AAPTPPGKTGPSAAQAGK 851
Query: 941 PTHQAPAEAAPESVGEAETA 960
+ +S GEA A
Sbjct: 852 QDDSGSSSEESDSDGEAPAA 871
Score = 35.0 bits (79), Expect = 0.39
Identities = 96/465 (20%), Positives = 165/465 (35%), Gaps = 73/465 (15%)
Query: 615 WENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEV-PEAGGEGLT 673
W+ + +R +EDAA ++ + ++E E + E+E ++ P +
Sbjct: 53 WQQTSELGRKR-KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
Query: 674 TQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRL 733
A + E + +E ++ G TG ++ P P+ G+ A + L
Sbjct: 112 VLGADLPSSMKEKAKAETEKA-GKTG-NSMPHPATGKTVANLLSGKSPRKSAEPSANTTL 169
Query: 734 QAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGE 793
+ E + GSV A G P + +AG DS ++ +++ +
Sbjct: 170 VS--------ETEEEGSVPA--FGAAAKPGMVSAGQA-----------DSSSEDTSSSSD 208
Query: 794 HAGGQEFGLEGSAEEEVTGRGSQVEAFES-REGGPWGGRVEAEES-AGA---EDSCGLDP 848
E +E A E++ QV A + +G P G A AGA + G
Sbjct: 209 -----ETDVEVKASEKIL----QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE 259
Query: 849 AGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLL 908
S+++ E + E LL+ +A G + Q + + +G AP
Sbjct: 260 EDSESSSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPP 314
Query: 909 DAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
G V + + +E S E +EE P P+ AP+ A +A A S R
Sbjct: 315 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRK 372
Query: 969 GAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEE 1028
GAA P ++V + + RS EE +
Sbjct: 373 GAA--------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALA 413
Query: 1029 ELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
++A + +PL ++P+ G PLG G G PG
Sbjct: 414 AMNAAQVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 450
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 62.8 bits (151), Expect = 2e-09
Identities = 183/895 (20%), Positives = 320/895 (35%), Gaps = 130/895 (14%)
Query: 111 SQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNRE 170
++A Q +G+T++ P+ + + A G +AQ + + + + E
Sbjct: 279 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 338
Query: 171 ERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGP--KAAGDNREMEQGV 228
E EEE +A+ G A + E+ K A P K +++ G
Sbjct: 339 E-----SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 393
Query: 229 READAGETEEPG-----AEGAGKGEEVVVVEKACE----STRAWGTWGPGAEPEDWGILG 279
+E D+ + E A A +V + K+ + ST G G GA P G +G
Sbjct: 394 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 453
Query: 280 REEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGI 339
G+ E + EE+ S GE + +E + + T+S +
Sbjct: 454 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 513
Query: 340 ASGGEAGTASGGEEAGTASGGDEAWTTSGKEEA----------DLLGVRQTEYGAVPGER 389
+G A + + +E+ ++ EEA L + QT+ A P +
Sbjct: 514 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK--ACPKKT 571
Query: 390 LLEATGKVWVLEEEGDEEREA--EVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAG 447
A+ KV + R+A SP P V G T+ AE ++ E+ ++
Sbjct: 572 NTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG--GTQRPAEDSSSSEES----DSE 625
Query: 448 ESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEG 507
E G G+ + + L ++A ++ + A G + V ++ +AE
Sbjct: 626 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV----KAEK 681
Query: 508 TADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQ 567
D E++ EEE EE+ A+ + SV K Q A+ P+ +
Sbjct: 682 QEDSESS-----EEESDSEEAAASPAQ----------VKTSVKKTQAKANPAAARAPSAK 726
Query: 568 PEEREAGEVELMGVLALSKEEQERSLEAGP------------RHAGSVKPEASEAFPGAW 615
G+V V A ++ +Q + P R SV P +A A
Sbjct: 727 GTISAPGKV----VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 781
Query: 616 ENRTRKDMERGNTQEDAADGEQRE--EEETAGGQT------LAAEAEGDRESELSEVPEA 667
+ +T + + G+++E++ E+ E + G+T LA E R+ P
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841
Query: 668 GGEGLTTQDAGCGTEEGEASVSENQELDGSTGA--------------------DAGPCPS 707
G A G ++ S SE + DG A AGP +
Sbjct: 842 TGPSA----AQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 897
Query: 708 LGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDRE----DAQTGSVAAGIMGGDVVPH 763
+A A T + ++ T+R +P + +T V + P
Sbjct: 898 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 957
Query: 764 ISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESR 823
S AGA + E + D K++E A + + A +T +V A ++
Sbjct: 958 ASMAGASSSKES--SRISDGKKQEGPAT-------QVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 824 EGGPWGGRVEAEESAGAEDSCGLDPA---GSQTARAEGMGAMVEAGGLLEKWTLLEEEAV 880
E P R + S+G + + G PA S + +A+G + + K +++
Sbjct: 1009 EAQPPVAR--TQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRK-----PKLPEVQQATK 1061
Query: 881 GWQEREQREDSEGRCGDYHPEGEAPR-LLDAEGLMVTGGRRAE--AKETEPESLE 932
+ + EDS +GE P+ A L+ R E +ET ES E
Sbjct: 1062 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1116
Score = 58.5 bits (140), Expect = 3e-08
Identities = 180/920 (19%), Positives = 305/920 (33%), Gaps = 152/920 (16%)
Query: 85 GDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKA 144
G R+ E ++ + D S +E ++ ETAKA + L + S
Sbjct: 60 GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKA------TPRLASTNSSVL 113
Query: 145 GSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHG 204
G+ +A+ E + N + + ++ A +
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 205 ETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACE------ 258
E EG A G A + G+ AG+ + + + +E V KA E
Sbjct: 174 EEEGSVPAFGAAA-------KPGM--VSAGQADSSSEDTSSSSDETDVEVKASEKILQVR 224
Query: 259 --STRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGG 316
S A GT G GA P G G ++T G+ E D E + S E ET +
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAK 280
Query: 317 EEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLG 376
+ + G+ + + A + A A G+ +G A +GK E D
Sbjct: 281 ALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK-----TGPAVAKAQAGKREEDSQS 335
Query: 377 VRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTA 436
+ E + +EE A+ P K PQV + A ES
Sbjct: 336 SSE---------------------ESDSEEEAPAQAKPSGKAPQVRAA--SAPAKESPRK 372
Query: 437 GREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPV 496
G ++ G + QV + GK+ E + + EE S R+ +
Sbjct: 373 GAAPAPPRKTGPA-AAQVQV-GKQEE------------------DSRSSSEESDSDREAL 412
Query: 497 AELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPE 556
A + A L +P+ +P A+ G LG KG GP
Sbjct: 413 AAM----NAAQVKPLGKSPQVKP----------ASTMGMGPLG-----------KGAGPV 447
Query: 557 LMG--GAQTPTKQ------------PEEREAGEVELMGVLALSKEEQERSLEAGPRHAGS 602
G G TP+ Q E ++ + E+ +A ++E+ ++ +
Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 507
Query: 603 VKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELS 662
K +A P A + + K M+ + E+++D EE A AA+A+
Sbjct: 508 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAK-----PAL 559
Query: 663 EVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAE 722
++P+ T ++ G+ + AG P++ R ED +
Sbjct: 560 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS 619
Query: 723 ADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGI-MGGDVVPHISAAGAGEA--LEGVLG- 778
+ S AV VG Q SV G+ + VP + G G A L G G
Sbjct: 620 EESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 672
Query: 779 --------QGWDSKEKEEAAAGEHAGGQEFGLEGSAEE------EVTGRGSQVEAFESRE 824
+ DS+ EE + E A ++ S ++ R + S
Sbjct: 673 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 732
Query: 825 GGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLL----EKWTLLEEEAV 880
G +A++ + ++ + + T A G ++ G + + T EE++
Sbjct: 733 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 792
Query: 881 GWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQ 940
+E E+ P G+ ++ A R+ A T P Q +
Sbjct: 793 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG-AAPTPPGKTGPSAAQAGK 851
Query: 941 PTHQAPAEAAPESVGEAETA 960
+ +S GEA A
Sbjct: 852 QDDSGSSSEESDSDGEAPAA 871
Score = 35.0 bits (79), Expect = 0.39
Identities = 96/465 (20%), Positives = 165/465 (35%), Gaps = 73/465 (15%)
Query: 615 WENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEV-PEAGGEGLT 673
W+ + +R +EDAA ++ + ++E E + E+E ++ P +
Sbjct: 53 WQQTSELGRKR-KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
Query: 674 TQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRL 733
A + E + +E ++ G TG ++ P P+ G+ A + L
Sbjct: 112 VLGADLPSSMKEKAKAETEKA-GKTG-NSMPHPATGKTVANLLSGKSPRKSAEPSANTTL 169
Query: 734 QAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGE 793
+ E + GSV A G P + +AG DS ++ +++ +
Sbjct: 170 VS--------ETEEEGSVPA--FGAAAKPGMVSAGQA-----------DSSSEDTSSSSD 208
Query: 794 HAGGQEFGLEGSAEEEVTGRGSQVEAFES-REGGPWGGRVEAEES-AGA---EDSCGLDP 848
E +E A E++ QV A + +G P G A AGA + G
Sbjct: 209 -----ETDVEVKASEKIL----QVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE 259
Query: 849 AGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLL 908
S+++ E + E LL+ +A G + Q + + +G AP
Sbjct: 260 EDSESSSEESSDSEEETPAAK---ALLQAKASG--KTSQVGAASAPAKESPRKGAAPAPP 314
Query: 909 DAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
G V + + +E S E +EE P P+ AP+ A +A A S R
Sbjct: 315 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV--RAASAPAKESPRK 372
Query: 969 GAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEE 1028
GAA P ++V + + RS EE +
Sbjct: 373 GAA--------PAPPRKTGPAAAQVQVGKQEEDSRS-----------SSEESDSDREALA 413
Query: 1029 ELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPG 1073
++A + +PL ++P+ G PLG G G PG
Sbjct: 414 AMNAAQVKPLGKSPQVKPASTMGMG--------PLGKGAGPVPPG 450
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 60.8 bits (146), Expect = 7e-09
Identities = 163/685 (23%), Positives = 242/685 (35%), Gaps = 87/685 (12%)
Query: 227 GVREADAGETEEPGAE---GAGKGEEVVVVEKACE------STRAWGTWGPGAEPEDWGI 277
G+ + ET PG E G GE + E S T PG E
Sbjct: 1013 GLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLP 1072
Query: 278 LGREEARTTPGREEARAILDGEEART-------ISG---GEEAETASGG-EEAETASGGE 326
G T PG E+ + GE T ISG GE ETA+ G E+ GE
Sbjct: 1073 SGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGE 1132
Query: 327 EAGTASGGEE--AGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEY-- 382
TA+ G E +G+ SG TA+ G E + E T+ D+ G+ E
Sbjct: 1133 VLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLE 1192
Query: 383 GAVPGERLLEA--TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTE-----EAAESQT 435
A PG + +G+V G E+ S + G E E E+
Sbjct: 1193 TAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAA 1252
Query: 436 AGREAVGGQEAGESFE----GQVDLRGKEAEMRQDLGIRADRARMEEL--VQAEEAQEER 489
G E + G +GE E G D+ G + + +EE+ + + E E
Sbjct: 1253 PGVEDISGLPSGEVLETAAPGVEDISG----LPSGEVLETTAPGVEEISGLPSGEVLETT 1308
Query: 490 GSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCG-LLGVEWGGLTHS 548
D ++ LPS E TA P +GE E + ++ G L G+ GG
Sbjct: 1309 APGVDEISGLPSGEVLETTAPGVEEISGLP----SGEVLETSTSAVGDLSGLPSGGEVLE 1364
Query: 549 VTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEAS 608
++ ++ G P+ + E A +E V L E + +G + P
Sbjct: 1365 ISVSGVEDISG---LPSGEVVETSASGIE--DVSELPSGEGLETSASGVEDLSRL-PSGE 1418
Query: 609 EAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAG 668
E E +A G +GG+ L A + ++LS +P +G
Sbjct: 1419 EVL------------------EISASGFGDLSGLPSGGEGLETSAS-EVGTDLSGLP-SG 1458
Query: 669 GEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPS--LGEAYARETEDEEAEADRT 726
EGL T +G G S E+ S D G PS LG A ET +
Sbjct: 1459 REGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGE 1518
Query: 727 SRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGA----GEALEGVLGQGWD 782
GLPD +G ++ +V ++A+ A G G+ G G
Sbjct: 1519 YSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEI 1578
Query: 783 S--KEKEEAAAGEHAG---GQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEES 837
S E +G +G G E + S +V+G ++ G P G + E+
Sbjct: 1579 SGLPSSELDISGRASGLPSGTELSGQASGSPDVSG---EIPGLFGVSGQPSGFPDTSGET 1635
Query: 838 AGAEDSCGLDPAGSQTARAEGMGAM 862
+G + GL +G E G +
Sbjct: 1636 SGVTELSGLS-SGQPGISGEASGVL 1659
Score = 39.7 bits (91), Expect = 0.016
Identities = 151/705 (21%), Positives = 234/705 (33%), Gaps = 123/705 (17%)
Query: 285 TTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGE 344
+T E R + A ISG +E G + SG E +G ASG + G
Sbjct: 1559 STASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGL 1618
Query: 345 AGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEE- 403
G + G+ +G D + TSG E L G+ + G + G EA+G ++ +
Sbjct: 1619 FGVS--GQPSGFP---DTSGETSGVTE--LSGLSSGQPG-ISG----EASGVLYGTSQPF 1666
Query: 404 GDEEREAEVSPFPK---QPQVL-GTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGK 459
G + E S P QP L G +G + G+ +G +F +
Sbjct: 1667 GITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVA 1726
Query: 460 EAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARP 519
+++ G+ + + L E + D G+ GT D P
Sbjct: 1727 PTTFKEEEGLGS--VELSGLPSGEADLSGKSGMVD------VSGQFSGTVDSSGFTSQTP 1778
Query: 520 E--------EELTGEESEAAQTSCGLLGVEWGG---------------LTHSVTK----- 551
E E++GE S A S G +G L SVT+
Sbjct: 1779 EFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQ 1838
Query: 552 --GQGPE---LMGGAQTPTKQPEEREAGEVELMGV---------------------LALS 585
G+GP + GA + +G ++L G+ + +
Sbjct: 1839 EAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTT 1898
Query: 586 KEEQERSLEAGPRHAGSVKPE----ASEAFPGAWENRTRKDM-ERGNTQEDAADGEQREE 640
E S+ G S PE SE G E +++ +R E +
Sbjct: 1899 NVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGK 1958
Query: 641 EETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGT---------EEGEASVSE- 690
TAG + A E+S VPE+ E +AG G + G +SE
Sbjct: 1959 VSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSET 2018
Query: 691 -----NQELDGSTGAD-AGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDRE 744
L+ S+G +G + E A + E+ TS G A GLP
Sbjct: 2019 TSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVG----TEAPGLPSAT 2074
Query: 745 DAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEG 804
+G + GD+ H S G + W ++ + A H + L
Sbjct: 2075 PTASGDRTE--ISGDLSGHTSQLGV-VISTSIPESEW--TQQTQRPAETHLEIESSSLLY 2129
Query: 805 SAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTAR-AEGMGAMV 863
S EE T + S P R +A SC +P G+ T + EG +
Sbjct: 2130 SGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICL 2189
Query: 864 EAGGLLEKWTLLEEEAV--GWQ-----------EREQREDSEGRC 895
G + +++E GW +RE D+E RC
Sbjct: 2190 CPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRC 2234
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 60.8 bits (146), Expect = 7e-09
Identities = 163/685 (23%), Positives = 242/685 (35%), Gaps = 87/685 (12%)
Query: 227 GVREADAGETEEPGAE---GAGKGEEVVVVEKACE------STRAWGTWGPGAEPEDWGI 277
G+ + ET PG E G GE + E S T PG E
Sbjct: 1013 GLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLP 1072
Query: 278 LGREEARTTPGREEARAILDGEEART-------ISG---GEEAETASGG-EEAETASGGE 326
G T PG E+ + GE T ISG GE ETA+ G E+ GE
Sbjct: 1073 SGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGE 1132
Query: 327 EAGTASGGEE--AGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEY-- 382
TA+ G E +G+ SG TA+ G E + E T+ D+ G+ E
Sbjct: 1133 VLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLE 1192
Query: 383 GAVPGERLLEA--TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTE-----EAAESQT 435
A PG + +G+V G E+ S + G E E E+
Sbjct: 1193 TAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAA 1252
Query: 436 AGREAVGGQEAGESFE----GQVDLRGKEAEMRQDLGIRADRARMEEL--VQAEEAQEER 489
G E + G +GE E G D+ G + + +EE+ + + E E
Sbjct: 1253 PGVEDISGLPSGEVLETAAPGVEDISG----LPSGEVLETTAPGVEEISGLPSGEVLETT 1308
Query: 490 GSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCG-LLGVEWGGLTHS 548
D ++ LPS E TA P +GE E + ++ G L G+ GG
Sbjct: 1309 APGVDEISGLPSGEVLETTAPGVEEISGLP----SGEVLETSTSAVGDLSGLPSGGEVLE 1364
Query: 549 VTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEAS 608
++ ++ G P+ + E A +E V L E + +G + P
Sbjct: 1365 ISVSGVEDISG---LPSGEVVETSASGIE--DVSELPSGEGLETSASGVEDLSRL-PSGE 1418
Query: 609 EAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAG 668
E E +A G +GG+ L A + ++LS +P +G
Sbjct: 1419 EVL------------------EISASGFGDLSGLPSGGEGLETSAS-EVGTDLSGLP-SG 1458
Query: 669 GEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPS--LGEAYARETEDEEAEADRT 726
EGL T +G G S E+ S D G PS LG A ET +
Sbjct: 1459 REGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGE 1518
Query: 727 SRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGA----GEALEGVLGQGWD 782
GLPD +G ++ +V ++A+ A G G+ G G
Sbjct: 1519 YSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEI 1578
Query: 783 S--KEKEEAAAGEHAG---GQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEES 837
S E +G +G G E + S +V+G ++ G P G + E+
Sbjct: 1579 SGLPSSELDISGRASGLPSGTELSGQASGSPDVSG---EIPGLFGVSGQPSGFPDTSGET 1635
Query: 838 AGAEDSCGLDPAGSQTARAEGMGAM 862
+G + GL +G E G +
Sbjct: 1636 SGVTELSGLS-SGQPGISGEASGVL 1659
Score = 35.0 bits (79), Expect = 0.39
Identities = 133/571 (23%), Positives = 195/571 (34%), Gaps = 98/571 (17%)
Query: 265 TWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASG--------- 315
T +E E G +G A G + + G + SG E + ASG
Sbjct: 1557 TASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIP 1616
Query: 316 ---GEEAETASGGEEAGTASGGEE-AGIASG--GEAGTASG---------------GEEA 354
G + + + +G SG E +G++SG G +G ASG GE +
Sbjct: 1617 GLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETS 1676
Query: 355 GTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSP 414
G + G A GV G G E++G +V + EV+P
Sbjct: 1677 GVPDLSGQPSGLPGFSGATS-GVPDLVSGTTSGSG--ESSGITFV------DTSLVEVAP 1727
Query: 415 FP-KQPQVLGTERTE-----EAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLG 468
K+ + LG+ EA S +G V GQ F G VD G ++ + G
Sbjct: 1728 TTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQ-----FSGTVDSSGFTSQTPEFSG 1782
Query: 469 IRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEES 528
+ + A V E ++ E GSS LPS G G+ + P + E
Sbjct: 1783 LPSGIAE----VSGESSRAEIGSS------LPS-GAYYGSGTPSSFPTVSLVDRTLVESV 1831
Query: 529 EAAQTSCGLLGVEWGGLTHSVTKGQGPELMG---------GAQTPTKQPEEREAGEVELM 579
A T+ G L S P++ G G Q+ +P G
Sbjct: 1832 TQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFS 1891
Query: 580 GVLALSKEEQ-ERSLEAGPRHAGSVKPEA----SEAFPGAWENRTRKDM-ERGNTQEDAA 633
G A + E S+ G S PE SE G E +++ +R
Sbjct: 1892 GDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQ 1951
Query: 634 DGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGT---------EEG 684
E + TAG + A E+S VPE+ E +AG G + G
Sbjct: 1952 LFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSG 2011
Query: 685 EASVSE------NQELDGSTGAD-AGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVA 737
+SE L+ S+G +G + E A + E+ TS G A
Sbjct: 2012 SPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVG----TEA 2067
Query: 738 VGLPDREDAQTGSVAAGIMGGDVVPHISAAG 768
GLP +G + GD+ H S G
Sbjct: 2068 PGLPSATPTASGDRTE--ISGDLSGHTSQLG 2096
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 58.2 bits (139), Expect = 4e-08
Identities = 142/651 (21%), Positives = 221/651 (33%), Gaps = 92/651 (14%)
Query: 140 KKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMA---RGA 196
KK K G + SG+ + ++ S EE EE+ E G+A +
Sbjct: 531 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 590
Query: 197 ESEWTWHGETEGKAGAVGPKAA----------------GDNREMEQGVREADAGETEEPG 240
E+E + E K V P A+ D + V+ A TE
Sbjct: 591 EAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTA 650
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
+E + + V K E R T E +G + R G D E
Sbjct: 651 SEMQEEMKGSVEEPKPEEPKRKVDT---SVSWEALICVGSSKKRARRGSSS-----DEEG 702
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
GG+ + G++ ET + G AG+ G +S +AG+ + GE T
Sbjct: 703 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 762
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
T K ++ L + ++ G + +T E G EE + F +
Sbjct: 763 KRLVTPRKKSKSKL---EEKSEDSIAGSGVEHSTPDT----EPGKEESWVSIKKFIPGRR 815
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
+ +E A + AG G E V L +A R+ + + + E+
Sbjct: 816 KKRPDGKQEQAPVEDAG--PTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 873
Query: 481 Q--AEEAQEERGSSR-DPVAELPSDGEAEGTADLEATP---EARPEEELTGEESEAAQTS 534
Q A E +E S+ +A +DG T E +P A E L E+EAA
Sbjct: 874 QKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL-- 931
Query: 535 CGLLGVEWGGLTHSVTKGQGPELMGGAQTPT---KQPEEREAGEVELMGVLALSKEEQER 591
LT V + E++ + PT PE REA ++ L+ E
Sbjct: 932 ----------LTEEVLE---REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 978
Query: 592 SLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAA 651
+ AGP A E T T+ +A + + +T T
Sbjct: 979 AETAGPLGA---------------EEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQ 1023
Query: 652 EAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEA 711
E EG VP+ + TQ+ E V E +L G+ GP L
Sbjct: 1024 EVEGG-------VPDIEEQERRTQEVLQAVAE---KVKEESQLPGT----GGPEDVLQPV 1069
Query: 712 YARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVP 762
E E E +A+ + G + + V D ++A+T G + G P
Sbjct: 1070 QRAEAERPEEQAEAS---GLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTP 1117
Score = 54.7 bits (130), Expect = 5e-07
Identities = 192/932 (20%), Positives = 327/932 (35%), Gaps = 174/932 (18%)
Query: 225 EQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEAR 284
++G A AG+ ++P G GE + +ST +PE+ + A
Sbjct: 204 DEGEGAAGAGDHKDPSL---GAGEAASKESEPKQSTE---------KPEETLKREQSHAE 251
Query: 285 TTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGE 344
+P E +A+ + +E GEE + + AE+ + + T S ++ + G
Sbjct: 252 ISPPAESGQAVEECKEE-----GEEKQEKEPSKSAESPTSPVTSETGSTFKK--FFTQGW 304
Query: 345 AGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEG 404
AG EA ++E + + + V E+L + E+
Sbjct: 305 AGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTAS--------EQA 356
Query: 405 DEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQE----AGESFEGQVDLRGKE 460
+ AE + P+ E+ E +E Q +G + ++ A E F+ ++++ +
Sbjct: 357 HPQEPAESAHEPRLSAEY--EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVH--Q 412
Query: 461 AEMRQDLGIRADRARMEELVQAEEAQEERGS-SRDPVAELPSDG-EAEGTADLEATPEA- 517
E+ ++ + R EE Q E +E GS + + E+ ++ EAE +L E
Sbjct: 413 EEVVAEVHVSTVEERTEE--QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC 470
Query: 518 ------------RPEEELTGEESEAAQTSCGLLG------VEWGGLTHSVTKGQGPELMG 559
P+E++ + E + +L V+ L T +L G
Sbjct: 471 VSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 530
Query: 560 GAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRT 619
Q + + E+GE + + +E+++ + + PE E E
Sbjct: 531 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG------ESSASSPEEPEEIT-CLEKGL 583
Query: 620 RKDMERGNTQEDA-ADGEQREEEETAGG---------QTLAAEAEGDRESELSEVPEAGG 669
+ + G +E A +DGE++ E T + + +E D+E EL +V A
Sbjct: 584 AEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATL 643
Query: 670 EGLTTQDAGCGTEEGEASVSE------NQELDGSTGADAGPCPSLGEAYARETEDEEAEA 723
T A EE + SV E +++D S +A C + AR + E
Sbjct: 644 SS-TESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 702
Query: 724 DRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDS 783
+ G +A G D+E G +A S AG EG W+S
Sbjct: 703 GPKAMGGDHQKADEAG-KDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES 761
Query: 784 KEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGP--W--------GGRVE 833
++ + + LE +E+ + G G + ++ G W G R +
Sbjct: 762 FKRLVTPRKK----SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 817
Query: 834 AEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEG 893
+ G ++ ++ AG GA + + L E +AV ERE+ E +
Sbjct: 818 RPD--GKQEQAPVEDAGPT-------GANEDDSDVPAVVPLSEYDAV---EREKMEAQQA 865
Query: 894 RCGDYHPEGEAPRLLDAE---------GLMVTGGRRA------------EAKETEP---- 928
+ PE +A + E V G RA A TEP
Sbjct: 866 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 925
Query: 929 ---------ESLEH-VRGQEEQPTHQAP---------------AEAAPESVGEAETAEAM 963
E LE V +EE PT P AE PE+V AETA +
Sbjct: 926 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 985
Query: 964 GSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAP 1023
G+ G A++ E + + SQ P Q+ E P
Sbjct: 986 GAEEGTEASAAEET---------------TEMVSAVSQLTDSPDTTEEATPVQEVEGGVP 1030
Query: 1024 NPPEEELSAPEQRPLQLEEPLEPSPLRHDGTP 1055
+ E+E E E+ E S L G P
Sbjct: 1031 DIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 1062
Score = 53.5 bits (127), Expect = 1e-06
Identities = 241/1108 (21%), Positives = 399/1108 (36%), Gaps = 203/1108 (18%)
Query: 36 TVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSS 95
T++RE AE + ++G+ VEE +E G + E + P E GS+
Sbjct: 242 TLKREQSHAE---ISPPAESGQAVEECKEE---GEEKQEKEPSKSAESPTSPVTSETGST 295
Query: 96 AVE---QTW-GWGDGSS------------------HGSQAERQDSGAGETA-------KA 126
+ Q W GW +S + + ++ G E A +
Sbjct: 296 FKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQ 355
Query: 127 ARCQEP--SAH------------LEARKKSKAGSGACQDRSGQA-----QERQESHEQEV 167
A QEP SAH L + ++ G +++ E+ E H++EV
Sbjct: 356 AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEV 415
Query: 168 NREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQG 227
E + + E+ EE++ E + AE E P+ A +E+
Sbjct: 416 VAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE---------PQEAEPAKEL--- 463
Query: 228 VREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTP 287
V+ + + E +GA + V+ K E G +E E R + + +P
Sbjct: 464 VKLKETCVSGEDPTQGADLSPDEKVLSKPPE--------GVVSEVEMLSSQERMKVQGSP 515
Query: 288 GREEARAI----LDGEEARTISGGEEAET-------ASGGEEAETASGGEEAGTASGGEE 336
++ + L G++ + GG + E+ A + E G A + EE
Sbjct: 516 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEE 575
Query: 337 AGIASGGEAGTASGGE-EAGTASGGDE------AWTTSGKEEADLLGVRQTEYGAVPGE- 388
G A GE E G S G++ W + K VR+ E
Sbjct: 576 ITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL 635
Query: 389 -RLLEAT-GKVWVLEEEGDEEREAEV-SPFPKQP-QVLGTERTEEA-----AESQTAGRE 439
++ AT E EE + V P P++P + + T + EA + + A R
Sbjct: 636 DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRG 695
Query: 440 AVGGQEAGESFEG----QVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDP 495
+ +E G G + D GK+ E D GI L ++E +GSS
Sbjct: 696 SSSDEEGGPKAMGGDHQKADEAGKDKETGTD-GI---------LAGSQEHDPGQGSSSPE 745
Query: 496 VAELPSDGEAEGTAD---LEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKG 552
A P++GE T + TP + + +L E ++ S GVE T G
Sbjct: 746 QAGSPTEGEGVSTWESFKRLVTPRKKSKSKL----EEKSEDSIAGSGVEHS--TPDTEPG 799
Query: 553 QGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFP 612
+ + + + ++R G K+EQ +AGP A + P
Sbjct: 800 KEESWVSIKKFIPGRRKKRPDG-----------KQEQAPVEDAGPTGANEDDSDVPAVVP 848
Query: 613 -GAWENRTRKDMERGNTQEDAADGEQ-------REEEETAGGQTLAAEAEGDRESELSEV 664
++ R+ ME Q+ A EQ +E E+ AA A+G R + + E
Sbjct: 849 LSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEE 908
Query: 665 PEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEAD 724
+ + E EA++ + L+ A+ P P++ E E+ EA D
Sbjct: 909 RSPSWISASVTEP-LEQVEAEAALLTEEVLEREVIAEEEP-PTVTEPL---PENREARGD 963
Query: 725 RTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSK 784
V +A T + AG +G + SAA + + Q DS
Sbjct: 964 ----------TVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSP 1013
Query: 785 E-KEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDS 843
+ EEA + G +E +E T Q A + +E G + G ED
Sbjct: 1014 DTTEEATPVQEVEGGVPDIE--EQERRTQEVLQAVAEKVKEESQLPG------TGGPEDV 1065
Query: 844 CGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGR-CGDYHPEG 902
L P Q A AE EA GL ++ ++ + V QE + ++G+ G PE
Sbjct: 1066 --LQPV--QRAEAERPEEQAEASGLKKETDVVLK--VDAQEAKTEPFTQGKVVGQTTPES 1119
Query: 903 --EAPRL---LDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEA 957
+AP++ +++ L+ T + E+L V+ QE P P+SV
Sbjct: 1120 FEKAPQVTESIESSELVTT---------CQAETLAGVKSQEMVMEQAIP----PDSVETP 1166
Query: 958 ETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQ 1017
+E GS ++ PG+ + +S + PA Q+
Sbjct: 1167 TDSETDGS------TPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPA--QK 1218
Query: 1018 EEPPAPNPPEEELSAPEQRPLQLEEPLE 1045
E PPAP+ + EQ ++E+ LE
Sbjct: 1219 ERPPAPSSFVFQEETKEQS--KMEDTLE 1244
Score = 37.0 bits (84), Expect = 0.10
Identities = 54/233 (23%), Positives = 94/233 (40%), Gaps = 27/233 (11%)
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTS 367
EE T E +T + +A + G+E T GEE AS DE TS
Sbjct: 1565 EETATEMLTSELQTQAHVIKADSQDAGQE----------TEKEGEEP-QASAQDETPITS 1613
Query: 368 GKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEG----DEEREAEVSPFPKQPQVLG 423
KEE++ V Q + + EA+ K +E EG D++ E V P ++ G
Sbjct: 1614 AKEESESTAVGQAHSDI--SKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAG 1671
Query: 424 TERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAE--MRQDLGIRADRARMEELVQ 481
T+ E G + + E + D +G + + Q+ + A +
Sbjct: 1672 TKSVPE-----DDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKE 1726
Query: 482 AEEAQEERGSSRDPVAELP-SDGEAEGTADLEATPEARPEEELTGEESEAAQT 533
+ + + ++ E+ +G+ +D TP+A +EEL +E E+A++
Sbjct: 1727 SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQA--QEELQKQERESAKS 1777
Score = 35.0 bits (79), Expect = 0.39
Identities = 127/669 (18%), Positives = 229/669 (34%), Gaps = 126/669 (18%)
Query: 402 EEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFE--GQV----- 454
E+ E+ E S P +P+ G + EAA TA A + + GQ+
Sbjct: 8 EQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTING 67
Query: 455 ------------DLRGKE----------AEMRQDLGIRADRARMEELVQAEEAQEERGSS 492
DL G++ ++ +++ + R E V ++ +E +
Sbjct: 68 VAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATK 127
Query: 493 RDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGV-EWGGLTHSVTK 551
V ++ DG+ E +E P + E + +E+ G V ++ G +V K
Sbjct: 128 SAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKK 187
Query: 552 ------------------GQGPELMGGAQTP-----------------TKQPEE---REA 573
G+G G + P T++PEE RE
Sbjct: 188 DKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQ 247
Query: 574 GEVELM------GVLALSKEEQERSLEAGPRHAGS--VKPEASEA-------FPGAWENR 618
E+ + KEE E E P + P SE F W
Sbjct: 248 SHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGW 307
Query: 619 TRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAG 678
+K R +++ E+++E+E + E D ++E++ E Q+
Sbjct: 308 RKKTSFRKPKEDEVEASEKKKEQEPE-----KVDTEEDGKAEVASEKLTASEQAHPQEPA 362
Query: 679 CGTEEGEAS-------VSENQELDGSTG-ADAGPCPSLGEAYARETEDEEAEA------- 723
E S + +++ GS G ++ P P E + + E + E
Sbjct: 363 ESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 422
Query: 724 ---DRTSRRGWRLQAVAVGLPDRE----DAQTGSVAAGIMGGDVVPHISAAGAGEALEGV 776
+RT + ++ A +P E DA+ ++V +GE
Sbjct: 423 TVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEP---AKELVKLKETCVSGEDPT-- 477
Query: 777 LGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQV-EAFESREGGPWGGRVEAE 835
QG D E+ + G S++E + +GS + + F S G+ +
Sbjct: 478 --QGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKG 535
Query: 836 ESAGAEDSCGLD---PAGSQTARAEGMG-AMVEAGGLLEKWTLLEEEAVGWQEREQREDS 891
+ G ++ G PA S ++ E G + + E+ T LE+ Q+ + E+
Sbjct: 536 KRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG 595
Query: 892 EGRCGDYHPEGEAPRLLDAEGLMVTGGRRAE--AKETEPESLEHVRGQEEQPTHQAPAEA 949
G+ EG P + MVT +R ++ + + L+ V+ T +E
Sbjct: 596 ATSDGEKKREGVTPWASFKK--MVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEM 653
Query: 950 APESVGEAE 958
E G E
Sbjct: 654 QEEMKGSVE 662
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 58.2 bits (139), Expect = 4e-08
Identities = 142/651 (21%), Positives = 221/651 (33%), Gaps = 92/651 (14%)
Query: 140 KKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMA---RGA 196
KK K G + SG+ + ++ S EE EE+ E G+A +
Sbjct: 433 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 492
Query: 197 ESEWTWHGETEGKAGAVGPKAA----------------GDNREMEQGVREADAGETEEPG 240
E+E + E K V P A+ D + V+ A TE
Sbjct: 493 EAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTA 552
Query: 241 AEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE 300
+E + + V K E R T E +G + R G D E
Sbjct: 553 SEMQEEMKGSVEEPKPEEPKRKVDT---SVSWEALICVGSSKKRARRGSSS-----DEEG 604
Query: 301 ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGG 360
GG+ + G++ ET + G AG+ G +S +AG+ + GE T
Sbjct: 605 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 664
Query: 361 DEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQ 420
T K ++ L + ++ G + +T E G EE + F +
Sbjct: 665 KRLVTPRKKSKSKL---EEKSEDSIAGSGVEHSTPDT----EPGKEESWVSIKKFIPGRR 717
Query: 421 VLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELV 480
+ +E A + AG G E V L +A R+ + + + E+
Sbjct: 718 KKRPDGKQEQAPVEDAG--PTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 775
Query: 481 Q--AEEAQEERGSSR-DPVAELPSDGEAEGTADLEATP---EARPEEELTGEESEAAQTS 534
Q A E +E S+ +A +DG T E +P A E L E+EAA
Sbjct: 776 QKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL-- 833
Query: 535 CGLLGVEWGGLTHSVTKGQGPELMGGAQTPT---KQPEEREAGEVELMGVLALSKEEQER 591
LT V + E++ + PT PE REA ++ L+ E
Sbjct: 834 ----------LTEEVLE---REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 880
Query: 592 SLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAA 651
+ AGP A E T T+ +A + + +T T
Sbjct: 881 AETAGPLGA---------------EEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQ 925
Query: 652 EAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEA 711
E EG VP+ + TQ+ E V E +L G+ GP L
Sbjct: 926 EVEGG-------VPDIEEQERRTQEVLQAVAE---KVKEESQLPGT----GGPEDVLQPV 971
Query: 712 YARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVP 762
E E E +A+ + G + + V D ++A+T G + G P
Sbjct: 972 QRAEAERPEEQAEAS---GLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTP 1019
Score = 54.7 bits (130), Expect = 5e-07
Identities = 192/932 (20%), Positives = 327/932 (35%), Gaps = 174/932 (18%)
Query: 225 EQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEAR 284
++G A AG+ ++P G GE + +ST +PE+ + A
Sbjct: 106 DEGEGAAGAGDHKDPSL---GAGEAASKESEPKQSTE---------KPEETLKREQSHAE 153
Query: 285 TTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGE 344
+P E +A+ + +E GEE + + AE+ + + T S ++ + G
Sbjct: 154 ISPPAESGQAVEECKEE-----GEEKQEKEPSKSAESPTSPVTSETGSTFKK--FFTQGW 206
Query: 345 AGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEG 404
AG EA ++E + + + V E+L + E+
Sbjct: 207 AGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTAS--------EQA 258
Query: 405 DEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQE----AGESFEGQVDLRGKE 460
+ AE + P+ E+ E +E Q +G + ++ A E F+ ++++ +
Sbjct: 259 HPQEPAESAHEPRLSAEY--EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVH--Q 314
Query: 461 AEMRQDLGIRADRARMEELVQAEEAQEERGS-SRDPVAELPSDG-EAEGTADLEATPEA- 517
E+ ++ + R EE Q E +E GS + + E+ ++ EAE +L E
Sbjct: 315 EEVVAEVHVSTVEERTEE--QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC 372
Query: 518 ------------RPEEELTGEESEAAQTSCGLLG------VEWGGLTHSVTKGQGPELMG 559
P+E++ + E + +L V+ L T +L G
Sbjct: 373 VSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 432
Query: 560 GAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRT 619
Q + + E+GE + + +E+++ + + PE E E
Sbjct: 433 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG------ESSASSPEEPEEIT-CLEKGL 485
Query: 620 RKDMERGNTQEDA-ADGEQREEEETAGG---------QTLAAEAEGDRESELSEVPEAGG 669
+ + G +E A +DGE++ E T + + +E D+E EL +V A
Sbjct: 486 AEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATL 545
Query: 670 EGLTTQDAGCGTEEGEASVSE------NQELDGSTGADAGPCPSLGEAYARETEDEEAEA 723
T A EE + SV E +++D S +A C + AR + E
Sbjct: 546 SS-TESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 604
Query: 724 DRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDS 783
+ G +A G D+E G +A S AG EG W+S
Sbjct: 605 GPKAMGGDHQKADEAG-KDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES 663
Query: 784 KEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGP--W--------GGRVE 833
++ + + LE +E+ + G G + ++ G W G R +
Sbjct: 664 FKRLVTPRKK----SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 719
Query: 834 AEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEG 893
+ G ++ ++ AG GA + + L E +AV ERE+ E +
Sbjct: 720 RPD--GKQEQAPVEDAGPT-------GANEDDSDVPAVVPLSEYDAV---EREKMEAQQA 767
Query: 894 RCGDYHPEGEAPRLLDAE---------GLMVTGGRRA------------EAKETEP---- 928
+ PE +A + E V G RA A TEP
Sbjct: 768 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827
Query: 929 ---------ESLEH-VRGQEEQPTHQAP---------------AEAAPESVGEAETAEAM 963
E LE V +EE PT P AE PE+V AETA +
Sbjct: 828 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 887
Query: 964 GSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAP 1023
G+ G A++ E + + SQ P Q+ E P
Sbjct: 888 GAEEGTEASAAEET---------------TEMVSAVSQLTDSPDTTEEATPVQEVEGGVP 932
Query: 1024 NPPEEELSAPEQRPLQLEEPLEPSPLRHDGTP 1055
+ E+E E E+ E S L G P
Sbjct: 933 DIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 964
Score = 53.5 bits (127), Expect = 1e-06
Identities = 241/1108 (21%), Positives = 399/1108 (36%), Gaps = 203/1108 (18%)
Query: 36 TVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSS 95
T++RE AE + ++G+ VEE +E G + E + P E GS+
Sbjct: 144 TLKREQSHAE---ISPPAESGQAVEECKEE---GEEKQEKEPSKSAESPTSPVTSETGST 197
Query: 96 AVE---QTW-GWGDGSS------------------HGSQAERQDSGAGETA-------KA 126
+ Q W GW +S + + ++ G E A +
Sbjct: 198 FKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQ 257
Query: 127 ARCQEP--SAH------------LEARKKSKAGSGACQDRSGQA-----QERQESHEQEV 167
A QEP SAH L + ++ G +++ E+ E H++EV
Sbjct: 258 AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEV 317
Query: 168 NREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQG 227
E + + E+ EE++ E + AE E P+ A +E+
Sbjct: 318 VAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE---------PQEAEPAKEL--- 365
Query: 228 VREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTP 287
V+ + + E +GA + V+ K E G +E E R + + +P
Sbjct: 366 VKLKETCVSGEDPTQGADLSPDEKVLSKPPE--------GVVSEVEMLSSQERMKVQGSP 417
Query: 288 GREEARAI----LDGEEARTISGGEEAET-------ASGGEEAETASGGEEAGTASGGEE 336
++ + L G++ + GG + E+ A + E G A + EE
Sbjct: 418 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEE 477
Query: 337 AGIASGGEAGTASGGE-EAGTASGGDE------AWTTSGKEEADLLGVRQTEYGAVPGE- 388
G A GE E G S G++ W + K VR+ E
Sbjct: 478 ITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL 537
Query: 389 -RLLEAT-GKVWVLEEEGDEEREAEV-SPFPKQP-QVLGTERTEEA-----AESQTAGRE 439
++ AT E EE + V P P++P + + T + EA + + A R
Sbjct: 538 DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRG 597
Query: 440 AVGGQEAGESFEG----QVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDP 495
+ +E G G + D GK+ E D GI L ++E +GSS
Sbjct: 598 SSSDEEGGPKAMGGDHQKADEAGKDKETGTD-GI---------LAGSQEHDPGQGSSSPE 647
Query: 496 VAELPSDGEAEGTAD---LEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKG 552
A P++GE T + TP + + +L E ++ S GVE T G
Sbjct: 648 QAGSPTEGEGVSTWESFKRLVTPRKKSKSKL----EEKSEDSIAGSGVEHS--TPDTEPG 701
Query: 553 QGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFP 612
+ + + + ++R G K+EQ +AGP A + P
Sbjct: 702 KEESWVSIKKFIPGRRKKRPDG-----------KQEQAPVEDAGPTGANEDDSDVPAVVP 750
Query: 613 -GAWENRTRKDMERGNTQEDAADGEQ-------REEEETAGGQTLAAEAEGDRESELSEV 664
++ R+ ME Q+ A EQ +E E+ AA A+G R + + E
Sbjct: 751 LSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEE 810
Query: 665 PEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEAD 724
+ + E EA++ + L+ A+ P P++ E E+ EA D
Sbjct: 811 RSPSWISASVTEP-LEQVEAEAALLTEEVLEREVIAEEEP-PTVTEPL---PENREARGD 865
Query: 725 RTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSK 784
V +A T + AG +G + SAA + + Q DS
Sbjct: 866 ----------TVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSP 915
Query: 785 E-KEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDS 843
+ EEA + G +E +E T Q A + +E G + G ED
Sbjct: 916 DTTEEATPVQEVEGGVPDIE--EQERRTQEVLQAVAEKVKEESQLPG------TGGPEDV 967
Query: 844 CGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGR-CGDYHPEG 902
L P Q A AE EA GL ++ ++ + V QE + ++G+ G PE
Sbjct: 968 --LQPV--QRAEAERPEEQAEASGLKKETDVVLK--VDAQEAKTEPFTQGKVVGQTTPES 1021
Query: 903 --EAPRL---LDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEA 957
+AP++ +++ L+ T + E+L V+ QE P P+SV
Sbjct: 1022 FEKAPQVTESIESSELVTT---------CQAETLAGVKSQEMVMEQAIP----PDSVETP 1068
Query: 958 ETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQ 1017
+E GS ++ PG+ + +S + PA Q+
Sbjct: 1069 TDSETDGS------TPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPA--QK 1120
Query: 1018 EEPPAPNPPEEELSAPEQRPLQLEEPLE 1045
E PPAP+ + EQ ++E+ LE
Sbjct: 1121 ERPPAPSSFVFQEETKEQS--KMEDTLE 1146
Score = 37.0 bits (84), Expect = 0.10
Identities = 54/233 (23%), Positives = 94/233 (40%), Gaps = 27/233 (11%)
Query: 308 EEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTS 367
EE T E +T + +A + G+E T GEE AS DE TS
Sbjct: 1467 EETATEMLTSELQTQAHVIKADSQDAGQE----------TEKEGEEP-QASAQDETPITS 1515
Query: 368 GKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEG----DEEREAEVSPFPKQPQVLG 423
KEE++ V Q + + EA+ K +E EG D++ E V P ++ G
Sbjct: 1516 AKEESESTAVGQAHSDI--SKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAG 1573
Query: 424 TERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAE--MRQDLGIRADRARMEELVQ 481
T+ E G + + E + D +G + + Q+ + A +
Sbjct: 1574 TKSVPE-----DDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKE 1628
Query: 482 AEEAQEERGSSRDPVAELP-SDGEAEGTADLEATPEARPEEELTGEESEAAQT 533
+ + + ++ E+ +G+ +D TP+A +EEL +E E+A++
Sbjct: 1629 SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQA--QEELQKQERESAKS 1679
>gi|7706635 cornulin [Homo sapiens]
Length = 495
Score = 57.4 bits (137), Expect = 7e-08
Identities = 83/368 (22%), Positives = 132/368 (35%), Gaps = 50/368 (13%)
Query: 317 EEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLG 376
E AE A G +E+G+ G + G +GT E G A G +S ++ G
Sbjct: 91 ESAEGACGSQESGSLHSGASQELGEGQRSGT-----EVGRAGKGQHYEGSSHRQSQQ--G 143
Query: 377 VRQTEYGAVPGERLLEATGKVWV--LEEEGDEEREAEVSPFPKQPQVLG-TERTEEAAES 433
R V + +ATG WV + + + + + +SP Q Q+ G TE+T++A E
Sbjct: 144 SRGQNRPGVQTQG--QATGSAWVSSYDRQAESQSQERISP---QIQLSGQTEQTQKAGEG 198
Query: 434 ------------QTAGREAVGGQEAGESF--EGQVDLRGKEAEMRQDLGI---RADRARM 476
Q RE + GE+ G G + QD R +
Sbjct: 199 KRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQ 258
Query: 477 EELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEA-TPEARPEEELTGEE-SEAAQTS 534
E E G R ++ + G A+ A TP E++ + + S + QT
Sbjct: 259 EATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQ 318
Query: 535 CGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVL----ALSKEEQE 590
G G H + Q + + G T + E E + + A + + +
Sbjct: 319 ESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQ 378
Query: 591 RSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLA 650
+G R PEA E PG G Q A+ R+E + +
Sbjct: 379 TQPGSGQRWMQVSNPEAGETVPG------------GQAQTGASTESGRQEWSSTHPRRCV 426
Query: 651 AEAEGDRE 658
E +GDR+
Sbjct: 427 TEGQGDRQ 434
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 56.6 bits (135), Expect = 1e-07
Identities = 73/310 (23%), Positives = 126/310 (40%), Gaps = 47/310 (15%)
Query: 60 EEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSG 119
+EE Q DL RG ++ G R+ V +Q G S ++ E ++S
Sbjct: 144 DEERQRDLPAQRGEESSEEEEKGYKGKTRKKPV---VKKQAPGKASVSRKQAREESEESE 200
Query: 120 AGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQE 179
A + A+ E + ++ K+S+ Q E + +++ REE + E+E
Sbjct: 201 AEPVQRTAKKVEGNKGTKSLKESE-----------QESEEEILAQKKEQREEEVEEEEKE 249
Query: 180 EEEEE----VRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGE 235
E+EE+ R R G + A E + +++ K + GD+ E+ A +G+
Sbjct: 250 EDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAK------RLLGDSDSEEEQKEAASSGD 303
Query: 236 TEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEAR-A 294
+G+ E V K+ + T+ G ED G+ E R+ AR
Sbjct: 304 D-------SGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLG 356
Query: 295 ILDGEEA---RTISGGEEAETASGGEEAE--------TASGGEEAGTASGGEEAGIASGG 343
GEE+ R +S E A GG + E ++ G ++S + + A GG
Sbjct: 357 STSGEESDLEREVSDSE----AGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGG 412
Query: 344 EAGTASGGEE 353
+AG+ GE+
Sbjct: 413 KAGSGRRGED 422
Score = 47.8 bits (112), Expect = 6e-05
Identities = 91/368 (24%), Positives = 137/368 (37%), Gaps = 74/368 (20%)
Query: 129 CQEPSA-HLEARKKSKAGSGACQ-DRSGQAQERQESHEQEVNREERLR--SWEQEEEEEE 184
C +P +S++GS A D G + + E +EE R S EE +E
Sbjct: 86 CSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDE 145
Query: 185 VRAREPGMARGAES----EWTWHGETE----------GKAGAVGPKAAGDNREME----- 225
R R+ RG ES E + G+T GKA +A ++ E E
Sbjct: 146 ERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQ 205
Query: 226 ------------QGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPE 273
+ ++E++ EE A+ + EE V E+ E E
Sbjct: 206 RTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEED----------EEKG 255
Query: 274 DWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASG 333
DW R R REE R+ +A+ + G ++E E+ E AS G+++G
Sbjct: 256 DWKPRTRSNGRRKSAREE-RSCKQKSQAKRLLGDSDSEE----EQKEAASSGDDSGR--- 307
Query: 334 GEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEA 393
E + E T G + + S DE SGK E G R+ RL
Sbjct: 308 DREPPVQRKSEDRTQLKGGKRLSGSSEDE--EDSGKGEPTAKGSRKM-------ARLGST 358
Query: 394 TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQ 453
+G EE D ERE S PQ G + + +S GR + + S +G
Sbjct: 359 SG------EESDLEREVSDSEAGGGPQ--GERKNRSSKKSSRKGRT----RSSSSSSDGS 406
Query: 454 VDLRGKEA 461
+ +G +A
Sbjct: 407 PEAKGGKA 414
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/301 (20%), Positives = 107/301 (35%), Gaps = 44/301 (14%)
Query: 400 LEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGK 459
+EE DEER+ ++ P Q +E E+ + +T + V Q G++ + R +
Sbjct: 139 VEESSDEERQRDL---PAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREE 195
Query: 460 EAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARP 519
E E VQ + E + E + E E A + E
Sbjct: 196 SEESEA------------EPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEV 243
Query: 520 EEELTGEESEAAQTSCGLLGVEWGGLTHS-------------VTKGQGPELMGGAQTPTK 566
EEE E+ E +W T S K Q L+G + + +
Sbjct: 244 EEEEKEEDEEKG---------DWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEE 294
Query: 567 QPEEREAGEVELMG--VLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDME 624
Q E +G+ K E L+ G R +GS + E +RK
Sbjct: 295 QKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMAR 354
Query: 625 RGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEG 684
G+T + +D E+ + AGG +G+R++ S+ G ++ + G+ E
Sbjct: 355 LGSTSGEESDLEREVSDSEAGG-----GPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEA 409
Query: 685 E 685
+
Sbjct: 410 K 410
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sapiens]
Length = 1101
Score = 56.6 bits (135), Expect = 1e-07
Identities = 125/525 (23%), Positives = 189/525 (36%), Gaps = 79/525 (15%)
Query: 590 ERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTL 649
+ LEA P + + P ++ +++ + + ED++ E E G+
Sbjct: 474 DEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEP-EWVGAEDGEVA 532
Query: 650 AAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVS---ENQELDGSTGADAGPCP 706
AEA G S + P G G + G G + E SV ++ LD + A C
Sbjct: 533 QAEAAGAAFSPGEDDP---GMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCC 589
Query: 707 SLGEAYAR-ETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHIS 765
SL A R E E+E E S ++ L + GS G + G+
Sbjct: 590 SLDSAGPRPEVEEENGEEVFLSA----YDDLSPLLGPKPPIWKGS---GSLEGE------ 636
Query: 766 AAGAGEALEGVLGQG------WDSKEKEEAAAG-------EHAGGQEFGLEGSAEEEVTG 812
AAG G LGQG W+ E ++A G E G E +E E G
Sbjct: 637 AAGCGRQ---ALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRG 693
Query: 813 R--GSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLE 870
GSQ REG + E+S G + + ++ G + E GG +
Sbjct: 694 EAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVE-----------EPGG--D 740
Query: 871 KWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPES 930
++T +E+ + +E EQRE+++ G +G + E V + AE + +
Sbjct: 741 EYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDK 800
Query: 931 LEHVRGQEEQPTHQAPAE--AAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLL--DV 986
+ +G E Q E +PE+ E E G + + G L D
Sbjct: 801 GQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDT 860
Query: 987 SVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLEEPLEP 1046
S V + P + E AP PP+ E PE +P
Sbjct: 861 LSEGSGVASLEVDCAKEGNPH-------SSEMEEVAPQPPQPEEMEPEG---------QP 904
Query: 1047 SPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQAR---LGRPKPQ 1088
SP DG P G G LA ++Q Q R + PKPQ
Sbjct: 905 SP---DGCLCPCSLGLGGVGMRLAST-LVQVQQVRSVPVVPPKPQ 945
Score = 50.4 bits (119), Expect = 9e-06
Identities = 101/445 (22%), Positives = 160/445 (35%), Gaps = 75/445 (16%)
Query: 267 GPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGE 326
GPG E G ++ L+ ++ + S E E G
Sbjct: 469 GPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWV--GA 526
Query: 327 EAGTASGGEEAGIA-SGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAV 385
E G + E AG A S GE G E G + S + D L + + ++
Sbjct: 527 EDGEVAQAEAAGAAFSPGEDDPGMGYLEE-LLGVGPQVEEFSVEPPLDDLSLDEAQFVLA 585
Query: 386 PGERLLEATGKVWVLEEEGDEE----REAEVSPF--PKQPQVLGTERTEEAAESQTAGRE 439
P L++ G +EEE EE ++SP PK P G+ E E+ GR+
Sbjct: 586 PSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLE--GEAAGCGRQ 643
Query: 440 AVG-GQEAGESFEGQVDLRGKEAEMRQDLGIRAD-RARMEELVQAEEAQEERGSSRDPVA 497
A+G G E +E D K+AE L IR + E V+A +A E+RG
Sbjct: 644 ALGQGGEEQACWEVGED---KQAEPGGRLDIREEAEGSPETKVEAGKASEDRG------- 693
Query: 498 ELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPEL 557
EA G+ + + EE +E ++ G + +G E
Sbjct: 694 ------EAGGSQETKVRLREGSREETEAKEEKSK-----------GQKKADSMEAKGVEE 736
Query: 558 MGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWEN 617
GG + ++ +E E E E + +E +EAG
Sbjct: 737 PGGDEYTDEKEKEIEREEDE---------QREEAQVEAG--------------------- 766
Query: 618 RTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDA 677
+D+E+G ++ A+ + ++ E +G RE E + G+G ++
Sbjct: 767 ---RDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSP 823
Query: 678 GCGTEEGEASVSENQEL-DGSTGAD 701
TE G VS+ +E DG D
Sbjct: 824 EAATEGGAGEVSKERESGDGEAEGD 848
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/263 (27%), Positives = 106/263 (40%), Gaps = 39/263 (14%)
Query: 104 GDGSSHGSQAE--RQDSGAGETAKAA------RCQEPSAHLEARKKSKAGSGACQDRSGQ 155
G GS G A RQ G G +A + EP L+ R++++ GS + +G+
Sbjct: 629 GSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAE-GSPETKVEAGK 687
Query: 156 AQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGP 215
A E + E ++E ++R E EE E + + + A+S E G
Sbjct: 688 ASE--DRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDE 745
Query: 216 KAAGDNREMEQGVREA--DAGETEEPGAEGAGKGEEV--VVVEKACESTRAWGTWGPGAE 271
K RE ++ EA +AG E GA+ EE VV ++ E R E
Sbjct: 746 KEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVR---------E 796
Query: 272 PEDWGIL--GREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAG 329
ED G G EAR G DGE++R+ E +E E+ G E
Sbjct: 797 DEDKGQREKGYHEARKDQG--------DGEDSRSPEAATEGGAGEVSKERESGDGEAEGD 848
Query: 330 TASGG---EEAGIASGGEAGTAS 349
+GG EE ++ G +G AS
Sbjct: 849 QRAGGYYLEEDTLSEG--SGVAS 869
Score = 41.2 bits (95), Expect = 0.005
Identities = 61/243 (25%), Positives = 97/243 (39%), Gaps = 32/243 (13%)
Query: 26 VSYLLGDAVP------TVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAG 79
+S LLG P ++E EA G A+G+ G E Q E Q E G
Sbjct: 616 LSPLLGPKPPIWKGSGSLEGEAAGC---GRQALGQGG-----EEQACWEVGEDKQAEPGG 667
Query: 80 RLRGPGDDRRHEVGSSAVEQTWGWGD---GSSHGSQAE--RQDSGAGETAKA----ARCQ 130
RL D R GS + G G + GSQ R G+ E +A ++ Q
Sbjct: 668 RL----DIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQ 723
Query: 131 EPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREP 190
+ + +EA+ + G D + ER+E ++E + E R EQ +E++V +
Sbjct: 724 KKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKW 783
Query: 191 GMARGAESEWTWHGETEGKA-----GAVGPKAAGDNREMEQGVREADAGETEEPGAEGAG 245
+ + E+E E +G+ A + G++ + E AGE + G G
Sbjct: 784 EVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDG 843
Query: 246 KGE 248
+ E
Sbjct: 844 EAE 846
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 56.2 bits (134), Expect = 2e-07
Identities = 186/778 (23%), Positives = 285/778 (36%), Gaps = 90/778 (11%)
Query: 8 LPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAA---------EELGVVAVGKTGKI 58
L GL Q + A + L+ + EREAQA+ E+L + K
Sbjct: 948 LAGLRQQII-ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW 1006
Query: 59 VEEEAQE-DLEG-LRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQA--- 113
E EA+ L+ L+ Q E RL ++ E+ + E+ G S QA
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSL 1066
Query: 114 -ERQDSGAGETAKAARCQEPSAHLEA-RKKSKAGSGACQDRSGQAQERQESHEQEVNREE 171
E + + E R + LE R+K A S QDRS E + REE
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Query: 172 RLRSWEQEEEEEEVRAREPGMARGA---ESEWTWHGETEGKAGAVGPKAAGDNREM---E 225
+ QE + +AR+ G R + E+E E + + G RE+ +
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAE-----ELRTQLRLLEDARDGLRRELLEAQ 1181
Query: 226 QGVREADAG---ETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGI-LGRE 281
+ +RE+ G + +E G GE E S + AE E + L E
Sbjct: 1182 RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANE 1241
Query: 282 EARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIAS 341
+ +E+ A+L EEART G E E +G +E E + EA +
Sbjct: 1242 D------KEQKLALL--EEARTAVGKEAGELRTGLQEVERSR--LEARRELQELRRQMKM 1291
Query: 342 GGEAGTASGGEEA---GTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVW 398
T G E A G + G+ A S +E LG+RQ + GE LE +
Sbjct: 1292 LDSENTRLGRELAELQGRLALGERAEKESRRE---TLGLRQR---LLKGEASLEVMRQEL 1345
Query: 399 VLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTA--GREAVGGQEAGESFEGQVDL 456
+ + +E+E E ++ ++LG+ E Q R EA + ++ L
Sbjct: 1346 QVAQRKLQEQEGEFR--TRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL 1403
Query: 457 RGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPE 516
R AE R G+ A+ AR+E VQ A+ + G R + G A +P
Sbjct: 1404 RLSAAEGRAQ-GLEAELARVE--VQRRAAEAQLGGLRSALRRGLGLGRA-------PSPA 1453
Query: 517 ARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEV 576
RP ++ A + GL T + G P G A +P + EA
Sbjct: 1454 PRPVPGSPARDAPAEGSGEGLNSPS----TLECSPGSQPPSPGPATSPASPDLDPEA--- 1506
Query: 577 ELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQE-DAADG 635
+ G L E + L + R ++ + S E +D ++ A
Sbjct: 1507 -VRGAL----REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVA 1561
Query: 636 EQREEEETAGGQ------TLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVS 689
E E + G+ LA + E R SE A + + T + E E S
Sbjct: 1562 ESEEARRSVDGRLSGVQAELALQEESVRRSERER--RATLDQVATLERSLQATESELRAS 1619
Query: 690 ENQ--ELDGSTGADAGPCPSLGEAY-ARETEDEEAEADRTSRRGWRLQAVAVGLPDRE 744
+ + ++ + G L E A E+ + E R S G LQ +GL DRE
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG-ELQRSRLGLSDRE 1676
Score = 44.3 bits (103), Expect = 6e-04
Identities = 218/1044 (20%), Positives = 363/1044 (34%), Gaps = 132/1044 (12%)
Query: 65 EDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETA 124
+D+ G + + G LR D E + EQ D + QA +
Sbjct: 536 QDMRGRYEASQDLLGTLRKQLSDSESE-RRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594
Query: 125 KAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEE 184
++A L +R+KS + Q QA+E ++ E+ +E LR EEE+
Sbjct: 595 RSAN------ELLSREKSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 185 VRAREPG--MARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAE 242
A + G + R E + EGK + + + + + D + E+
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
Query: 243 GAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDG---- 298
A E VE T+ L EEA + A+ +
Sbjct: 708 EALTKAEAGRVELELSMTK----------------LRAEEASLQDSLSKLSALNESLAQD 751
Query: 299 --EEARTISGGEEAETASGG-----EEAETASGGEEAGTASGGEEAGIASGGEAGTASGG 351
+ R ++ EE ++A G E+ T + E+ E +A G G+
Sbjct: 752 KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
Query: 352 EEAGTASGGDEAWTTSGKEEADLLG-VRQTEYGAVPGERLLEATGKVWVLEEEGDEEREA 410
E+A A ++ T E + L + Q E+ LE + + E E
Sbjct: 812 EQAQEAL--EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAR 869
Query: 411 EVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEG----------QVDLRGKE 460
E K+ L + E +T EA + E+ EG Q++ R ++
Sbjct: 870 EKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929
Query: 461 AEMRQDLGIRADRARMEELV----QAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPE 516
E + A EL Q QE+ ++ +A+ E E A L
Sbjct: 930 LEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRA 989
Query: 517 ARPEE-ELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQ-PEEREAG 574
A E+ + E EAA L E L + + Q EL+ + ++ EE A
Sbjct: 990 AHEEDLQRLQREKEAAWRE---LEAERAQLQSQLQREQ-EELLARLEAEKEELSEEIAAL 1045
Query: 575 EVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAAD 634
+ E L L++ E++++L S K SE G + +E + DA
Sbjct: 1046 QQERDEGLLLAESEKQQALSLKE----SEKTALSEKLMGTRHSLATISLEMERQKRDA-- 1099
Query: 635 GEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLT-----TQDAGCGTEEGEASVS 689
+ R+E++ + L +E D ++ E A + + +D G ++ ++ +
Sbjct: 1100 -QSRQEQDRSTVNALTSELR-DLRAQREEAAAAHAQEVRRLQEQARDLG---KQRDSCLR 1154
Query: 690 ENQELDGST----GADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDRED 745
E +EL A G L EA + E +E + G +++ G +RE
Sbjct: 1155 EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 746 AQTGS--VAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLE 803
+ + + + + + IS A E E L E+ A G+ AG GL+
Sbjct: 1215 LRRSNEELRSAVKKAES-ERISLKLANEDKEQKLAL----LEEARTAVGKEAGELRTGLQ 1269
Query: 804 GSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGA-- 861
+ R E + E A + L + +R E +G
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329
Query: 862 -MVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRR 920
+++ LE ++ +E Q + Q ++ E R + RLL G
Sbjct: 1330 RLLKGEASLE---VMRQELQVAQRKLQEQEGEFRTRER-------RLL---------GSL 1370
Query: 921 AEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLP 980
EA+ TE + L+H RG E + A AEAA + + A G A+G L
Sbjct: 1371 EEARGTEKQQLDHARGLELK-LEAARAEAAELGL---RLSAAEGRAQG----------LE 1416
Query: 981 GSLLDVSVPR--SRVHLSRSSSQRRSRPSFRRTPAWEQQEEP--PAPNPPEEELSAPEQR 1036
L V V R + L S R R P+ + P PA + P E
Sbjct: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
Query: 1037 PLQLE-----EPLEPSPLRHDGTP 1055
P LE +P P P +P
Sbjct: 1477 PSTLECSPGSQPPSPGPATSPASP 1500
>gi|4502805 chromogranin A precursor [Homo sapiens]
Length = 457
Score = 54.7 bits (130), Expect = 5e-07
Identities = 90/385 (23%), Positives = 146/385 (37%), Gaps = 49/385 (12%)
Query: 111 SQAERQDSGAGETAKAARCQEPSAH--LEARKKSKAGSGACQDRSGQAQERQESHEQEVN 168
S+ S E +A +EPS+ +E R+ SK + + G + QE
Sbjct: 105 SEVLENQSSQAELKEAV--EEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESK 162
Query: 169 REERLRS-WEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQG 227
E ++ E+EEEEEE P + ++ GP+A GD+ + QG
Sbjct: 163 AEGNNQAPGEEEEEEEEATNTHPPASLPSQKY-------------PGPQAEGDSEGLSQG 209
Query: 228 VREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTP 287
+ + + G + EPG + + EE E GP LG +E R
Sbjct: 210 LVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGE 269
Query: 288 GREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGT 347
R EA A+ DG G EEA+ G E E + EE + + G+ GG++G
Sbjct: 270 SRSEALAV-DGAGK---PGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQ-GLFRGGKSGE 324
Query: 348 ASGGEEAGTASGGDEAWTTSGK-EEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDE 406
EE + + W S + + D L T + G+ EEE +
Sbjct: 325 LEQEEERLS-----KEWEDSKRWSKMDQLAKELTAEKRLEGQE-----------EEEDNR 368
Query: 407 EREAEVSPFPKQ-------PQVLGTERTEEAAESQTAG--REAVGGQEAGESFEGQVDLR 457
+ ++S + PQ+ R +S AG + G E + EG + R
Sbjct: 369 DSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRR 428
Query: 458 GKEAEMRQDLGIRADRARMEELVQA 482
++ E+ I A+ ++ +QA
Sbjct: 429 PEDQELESLSAIEAELEKVAHQLQA 453
Score = 38.1 bits (87), Expect = 0.046
Identities = 82/357 (22%), Positives = 126/357 (35%), Gaps = 74/357 (20%)
Query: 399 VLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAG-------ESFE 451
VLE + + E P V+ E+ E++ E++ +G G + E
Sbjct: 107 VLENQSSQAELKEAVEEPSSKDVM--EKREDSKEAEKSGEATDGARPQALPEPMQESKAE 164
Query: 452 GQVDLRGKEAEMRQDLGIRADRARMEELV----QAEEAQE---------ERGSSRDPVAE 498
G G+E E ++ A + QAE E E+G S +P +
Sbjct: 165 GNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQ 224
Query: 499 LPSDGEAEGTADLEATPEARPEEE-----------LTGEESEAAQTSCGLLGVEWGGLTH 547
+ E E + EA EA PEEE L +E ++ L V+ G
Sbjct: 225 AKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAG-KP 283
Query: 548 SVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEA 607
+ Q PE G Q ++Q EE E V G+ K +G ++ E
Sbjct: 284 GAEEAQDPE-GKGEQEHSQQKEEEEEMAVVPQGLFRGGK-------------SGELEQE- 328
Query: 608 SEAFPGAWENRTR----KDMERGNTQEDAADGEQREEEETAGGQTLAAEA---------- 653
E WE+ R + + T E +G++ EE+ L+ A
Sbjct: 329 EERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGP 388
Query: 654 ---EGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVS-----ENQELDGSTGADA 702
G R S + EA GL Q G E+ E S E+QEL+ + +A
Sbjct: 389 QLRRGWRPSSREDSLEA---GLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEA 442
Score = 31.2 bits (69), Expect = 5.6
Identities = 47/166 (28%), Positives = 65/166 (39%), Gaps = 20/166 (12%)
Query: 794 HAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRV--------EAEESAGAEDSCG 845
H + G E E + + SQ E E+ E P V EAE+S A D
Sbjct: 92 HQQKKHSGFEDELSEVLENQSSQAELKEAVEE-PSSKDVMEKREDSKEAEKSGEATDGAR 150
Query: 846 LD--PAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSE--GRCGDYHPE 901
P Q ++AEG +A G E+ EEEA + G + E
Sbjct: 151 PQALPEPMQESKAEGNN---QAPGEEEEE---EEEATNTHPPASLPSQKYPGPQAEGDSE 204
Query: 902 GEAPRLLDAE-GLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAP 946
G + L+D E GL G +A+ +E E E E G+E P + P
Sbjct: 205 GLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGP 250
>gi|38372935 brevican isoform 1 [Homo sapiens]
Length = 911
Score = 54.3 bits (129), Expect = 6e-07
Identities = 66/267 (24%), Positives = 92/267 (34%), Gaps = 50/267 (18%)
Query: 116 QDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRS 175
+D G G + + P LE +S + G+A E +E +E E +EE
Sbjct: 412 EDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEE---- 467
Query: 176 WEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAA--GDNREMEQGVREADA 233
EEEEEEV E+ W W E + GP+A+ + E+ + +A A
Sbjct: 468 ---EEEEEEVE---------DEALWAWPSE----LSSPGPEASLPTEPAAQEESLSQAPA 511
Query: 234 GETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAE----PEDWGILGREEARTTPGR 289
+PGA GE E++R GP E P + + + R
Sbjct: 512 RAVLQPGASPLPDGES--------EASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAR 563
Query: 290 EEARAILDGEEARTISGGEEAETAS---------------GGEEAETASGGEEAGTASGG 334
E A G E + GE ET S G E E S TA G
Sbjct: 564 EVGEA-TGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAG 622
Query: 335 EEAGIASGGEAGTASGGEEAGTASGGD 361
+AS G A + GD
Sbjct: 623 TSVQAQPVLPTDSASRGGVAVVPASGD 649
>gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens]
Length = 1729
Score = 54.3 bits (129), Expect = 6e-07
Identities = 175/805 (21%), Positives = 280/805 (34%), Gaps = 145/805 (18%)
Query: 60 EEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGS----QAER 115
+++++ G+ +Q+ G+ G R E A Q W + S G+ AE
Sbjct: 807 QDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQE----ADVQDWEFRKRDSQGTYSSRDAEL 862
Query: 116 QDSGAGETAKAARCQEPSAHL---EARKKSKAGSGACQDRSGQAQE--RQESHEQEVNRE 170
QD G+ L E K+ G+ A QD + Q Q+ +++ H + +++
Sbjct: 863 QDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQD 922
Query: 171 ERLRSWEQEEEEEEV-----RAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREME 225
+ WE ++ + + RA EP +S W + G + + D ++
Sbjct: 923 ADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTL------DAQDRS 976
Query: 226 QGVREADAGETEEPGAEGAGKGEEVV--VVEKACESTR---------AWGTWGPGAEPED 274
G R +G + E + + E+ + V + E +R + G + P
Sbjct: 977 FGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVP 1036
Query: 275 WGILGREEARTTPG----------REEARAILDGEEARTISGGEEAETASGGEEAETASG 324
G LG+ + + +E +A G + + GE + GE + +
Sbjct: 1037 DGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGP 1096
Query: 325 GEEAGTASGGE--------EAGIAS------GGEAGTASGGEEAGTASGGD---EAWTTS 367
EA + G + EA S G + + +G + GG TT+
Sbjct: 1097 QREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTA 1156
Query: 368 GKEE-ADLLGVRQTEYGAVPG-----ERLLEATGKV-W-------------VLEEEGDEE 407
G + D LG+R E + G E A G++ W LE G EE
Sbjct: 1157 GSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEE 1216
Query: 408 R----------EAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLR 457
++V+ K +G A G+ G EAGE + +
Sbjct: 1217 PGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGV 1276
Query: 458 GKEAEMRQDLGIR-------ADRARMEELVQAEEAQEERGSSRD-PVAELPSDGEAEG-- 507
G +A+ DLG+R +EL + RD V P G ++G
Sbjct: 1277 G-QADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLR 1335
Query: 508 ---TADLEATPEARPEE-ELTGEESEAAQTSCGLLGVEW---GGLTHSVTKGQGPELMGG 560
++ T + P+ EL G SEA + G GV GL H+ + G E
Sbjct: 1336 GCGVGQMDWTQDLAPQNVELFGAPSEAREHGVG--GVSQCPEPGLRHNGSLSPGLE---- 1389
Query: 561 AQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASE--AFPGAWENR 618
A+ P E RE G E G ++ SLE P G EA A PG R
Sbjct: 1390 ARDPL---EARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPAR 1446
Query: 619 TRKDMERGNTQEDAADGEQRE---------------EEETAGGQTLAAEA-EGDRESELS 662
+G +E A + EEE AG E E R+S S
Sbjct: 1447 PPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPS 1506
Query: 663 EVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGP---CPSLGEAYARETEDE 719
P+ GE T+D A S+ S GP PS ++ +TE
Sbjct: 1507 WRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEIL 1566
Query: 720 E-----AEADRTSRRGWRLQAVAVG 739
+ + A+ +RG R + G
Sbjct: 1567 DSAMYRSRANLGRKRGHRAPVIRPG 1591
Score = 38.5 bits (88), Expect = 0.035
Identities = 128/601 (21%), Positives = 209/601 (34%), Gaps = 71/601 (11%)
Query: 415 FPKQPQVLGTERTE-----------EAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEM 463
FP +P LG R + EAAE+ AG AV +E G S +GQ G
Sbjct: 480 FPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQG--AGSAPSG 537
Query: 464 RQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEEL 523
++ D M L Q + + + P+ LP+ EGT L P + EE
Sbjct: 538 SGSSWVQGDDPSM-SLTQKGDGESQPQFPAVPLEPLPT---TEGTPGL---PLQQAEERY 590
Query: 524 TGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTP----TKQPEEREAGEVELM 579
+E A Q S L L + G E P PE +A VE
Sbjct: 591 ESQEPLAGQESPLPLATREAALP-ILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEE 649
Query: 580 GVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQRE 639
V E + EA S +P E+ ++ G A E ++
Sbjct: 650 AVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKD 709
Query: 640 -EEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGST 698
+ + + L ++ D +SE G+T +Q+ G
Sbjct: 710 TQSPSTCSEGLLGWSQKDLQSEF---------GITGDPQPSSFSPSSWCQGASQDY-GLG 759
Query: 699 GADAGPCPSLGEAYARETEDEEAE-ADRTSRRGWRLQAVAVGLPDREDA----QTGSVAA 753
GA P LGE R+ + + A S R W + +G + E + Q+ A
Sbjct: 760 GASPRGDPGLGE---RDWTSKYGQGAGEGSTREWASRC-GIGQEEMEASSSQDQSKVSAP 815
Query: 754 GIMGGD--VVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVT 811
G++ VV + G + E + Q W+ ++++ + G + +++
Sbjct: 816 GVLTAQDRVVGKPAQLGTQRSQEADV-QDWEFRKRD-------SQGTYSSRDAELQDQEF 867
Query: 812 GRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEK 871
G+ + + SR+ +S GA S + G + + G +
Sbjct: 868 GKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQD 927
Query: 872 WTLLEEE----AVGWQEREQREDSEGRCG---DYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
W + + G + E +E G+ DY G + R LDA+ + G R +
Sbjct: 928 WEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDY-SSGGSSRTLDAQDR--SFGTRPLSS 984
Query: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG-GAANSWSEAPLPGSL 983
PE + Q+E+ + P + +S+GE RG G S S A +P
Sbjct: 985 GFSPEEAQQ---QDEEFEKKIP--SVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGA 1039
Query: 984 L 984
L
Sbjct: 1040 L 1040
Score = 35.0 bits (79), Expect = 0.39
Identities = 89/429 (20%), Positives = 148/429 (34%), Gaps = 92/429 (21%)
Query: 317 EEAETASGGEEAGTASGGEEAGIASGGE-AGTASGGEEAGTASGGDEAWTTSGKEEADLL 375
E +E A E A E G++ G+ AG+A G + G D + + + K +
Sbjct: 502 EASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGD---- 557
Query: 376 GVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQT 435
G Q ++ AVP E P P T
Sbjct: 558 GESQPQFPAVPLE-------------------------PLPT-----------------T 575
Query: 436 AGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDP 495
G + Q+A E +E Q L G+E+ + A R +++ QE+ + P
Sbjct: 576 EGTPGLPLQQAEERYESQEPLAGQESPLP-----LATREAALPILEPVLGQEQPAAPDQP 630
Query: 496 ---VAELPSDGEAEGTADLEATPEARPE-EELTGEESEAAQTSCGLLGVEWGGLTHSVTK 551
A+ P G+A + EA AR E + E + + S G E
Sbjct: 631 CVLFADAPEPGQALPVEE-EAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLL 689
Query: 552 GQGPELMGGAQTPT-KQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEA 610
P GGA+ + ++ ++ G+L S+++ + + P+ S
Sbjct: 690 ASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGI------TGDPQPSSF 743
Query: 611 FPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGE 670
P +W +D G G G+R+ S+ + GE
Sbjct: 744 SPSSWCQGASQDYGLG------------------GASPRGDPGLGERD-WTSKYGQGAGE 784
Query: 671 GLTTQDA---GCGTEEGEASVSENQELDGSTGA------DAGPCPSLGEAYARETEDEEA 721
G T + A G G EE EAS S++Q + G G LG ++E + ++
Sbjct: 785 GSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDW 844
Query: 722 EADRTSRRG 730
E + +G
Sbjct: 845 EFRKRDSQG 853
Score = 30.8 bits (68), Expect = 7.3
Identities = 89/435 (20%), Positives = 145/435 (33%), Gaps = 91/435 (20%)
Query: 657 RESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARET 716
+ +L+EV E GG +++G G + +G +AG + +
Sbjct: 1234 KSKDLAEVGEGGGHS-QARESGVGQTDW-------------SGVEAGE-------FLKSR 1272
Query: 717 EDEEAEADRTSRRGWRLQAVAVGLPDREDAQTG------SVAAGIMGGDVVPHISAAGAG 770
E +AD T G R A E + G G+ +V + G+
Sbjct: 1273 ERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGS- 1331
Query: 771 EALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
+G+ G G + + A ++ + FG A E G SQ R G
Sbjct: 1332 ---QGLRGCGVGQMDWTQDLAPQNV--ELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSP 1386
Query: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQRED 890
+EA + A + + +G +T + + +E E + G
Sbjct: 1387 GLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFG--------A 1438
Query: 891 SEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKET---------EPESLEHVRGQEE-- 939
S GRC P + LL+ E L + + +E+ E E QEE
Sbjct: 1439 SPGRCPARPPPSGSQGLLE-EMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVL 1497
Query: 940 QPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSE--------APLPG---------- 981
+P +P P+ GEA E + G +A WS+ P G
Sbjct: 1498 EPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDF 1557
Query: 982 ------SLLDVSVPRSRVHLSRSSSQRR-----------SRPSFRRTPAWEQQEEPPA-- 1022
+LD ++ RSR +L R R S + ++ EP A
Sbjct: 1558 SFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASR 1617
Query: 1023 -PNPPEEELSAPEQR 1036
P+ EE + P+ R
Sbjct: 1618 VPSSDEEVVEEPQSR 1632
>gi|157674363 protein phosphatase 1, regulatory subunit 15A [Homo
sapiens]
Length = 674
Score = 53.9 bits (128), Expect = 8e-07
Identities = 111/505 (21%), Positives = 172/505 (34%), Gaps = 98/505 (19%)
Query: 496 VAELPSDGEAEGTADLEATPEAR-PEEELT-----GEESEAA--QTSCGLLGVEWGGLTH 547
+ E +GEA + TP R PEEE GE+ E +TS L WG L
Sbjct: 55 LVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEA-WGLLDD 113
Query: 548 -----------SVTKGQGPELMGGAQTP--------TKQPEEREAGEVELMGVLALSKEE 588
SV +GQG + G + P T Q ++ GE K E
Sbjct: 114 DDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGE---------EKAE 164
Query: 589 QERSLEAGPRHAGSVKPEASEAFPGAWEN----RTRKDMERGNTQEDAADGEQR------ 638
+E E + S P E P E +K+ R +T + +
Sbjct: 165 EEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCP 224
Query: 639 -EEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGS 697
EEE A ++G R++ +S P + G + + GEAS + ++
Sbjct: 225 GEEENQATEDKRTERSKGARKTSVS--PRSSGSDPRSWEY----RSGEASEEKEEKAHKE 278
Query: 698 TG-ADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIM 756
TG +A P P A A R + W Q D E+ + ++ A
Sbjct: 279 TGKGEAAPGPQ-----------SSAPAQRPQLKSWWCQP-----SDEEEGEVKALGAAEK 322
Query: 757 GGDV-VPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHA--GGQEFGLEGSAEEEVTGR 813
G+ P + V G D++E+E+ E + G E E A
Sbjct: 323 DGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPAT 382
Query: 814 GSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWT 873
G ++++ + G E++ ED + AE + A L+ W
Sbjct: 383 GVFLKSWVYQPG---------EDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWV 433
Query: 874 LLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEH 933
E + E+ ED + D + EA G ++ + P+ H
Sbjct: 434 YRPGE-----DTEEEEDEDVDSEDKEDDSEA----------ALGEAESDPHPSHPDQRAH 478
Query: 934 VRGQEEQPTHQAPAEAAPESVGEAE 958
RG +P + E A E GEAE
Sbjct: 479 FRGWGYRPGKETEEEEAAEDWGEAE 503
Score = 43.9 bits (102), Expect = 8e-04
Identities = 110/467 (23%), Positives = 155/467 (33%), Gaps = 99/467 (21%)
Query: 308 EEAETASG-GEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTT 366
EEAE + G GE+ ET T+S EA + G E G +
Sbjct: 81 EEAEDSGGPGEDRETLG----LKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFAD 136
Query: 367 SGKEEADLLGVRQTEYGAV--PGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGT 424
+ + +T G+ PGE E G V EEEG + S P V
Sbjct: 137 GQRAPLSPSLLIRTLQGSDKNPGEEKAEEEG---VAEEEGVNKFSYPPSHRECCPAV--E 191
Query: 425 ERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEE 484
E +E A + A R + G V G+E + D+ +
Sbjct: 192 EEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATE-----DKRTERSKGARKT 246
Query: 485 AQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGG 544
+ R S DP + GEA + +A E E G +S A
Sbjct: 247 SVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAP------------- 293
Query: 545 LTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVK 604
Q P+L ++ QP + E GEV+ +G E++ E P +
Sbjct: 294 -------AQRPQL----KSWWCQPSDEEEGEVKALGAA-----EKDGEAECPP----CIP 333
Query: 605 PEASEAFPGAWENRTRKDMERGNTQEDAAD------------------------------ 634
P + AF AW +D E +E+ D
Sbjct: 334 PPS--AFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVY 391
Query: 635 --GEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEAS--VSE 690
GE EEEE T +AE E + E+ S P + G TEE E SE
Sbjct: 392 QPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSE 451
Query: 691 NQELDGSTG---ADAGPCPS----------LGEAYARETEDEEAEAD 724
++E D A++ P PS G +ETE+EEA D
Sbjct: 452 DKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAED 498
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.126 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,847,621
Number of Sequences: 37866
Number of extensions: 2886177
Number of successful extensions: 24048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 1020
Number of HSP's that attempted gapping in prelim test: 14298
Number of HSP's gapped (non-prelim): 7100
length of query: 1088
length of database: 18,247,518
effective HSP length: 113
effective length of query: 975
effective length of database: 13,968,660
effective search space: 13619443500
effective search space used: 13619443500
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.