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Search of human proteins with 119120918
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
(573 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 1103 0.0
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 255 9e-68
gi|31982906 cingulin-like 1 [Homo sapiens] 96 7e-20
gi|42794779 myosin 18A isoform b [Homo sapiens] 89 1e-17
gi|28416946 myosin 18A isoform a [Homo sapiens] 89 1e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 80 5e-15
gi|21735548 centrosomal protein 2 [Homo sapiens] 79 1e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 79 1e-14
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 79 1e-14
gi|55770834 centromere protein F [Homo sapiens] 78 2e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 77 3e-14
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 77 6e-14
gi|109134347 NY-REN-58 antigen [Homo sapiens] 76 1e-13
gi|109134355 NY-REN-58 antigen [Homo sapiens] 76 1e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 75 1e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 75 1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 75 2e-13
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 75 2e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 74 3e-13
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 74 3e-13
gi|118498362 kinectin 1 isoform b [Homo sapiens] 74 4e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 4e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 4e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 4e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 4e-13
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 73 6e-13
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 73 8e-13
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 73 8e-13
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 73 8e-13
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 73 8e-13
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 1103 bits (2853), Expect = 0.0
Identities = 573/573 (100%), Positives = 573/573 (100%)
Query: 1 MSAFCLGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEEL 60
MSAFCLGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEEL
Sbjct: 1 MSAFCLGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEEL 60
Query: 61 ALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKAL 120
ALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKAL
Sbjct: 61 ALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKAL 120
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE 180
LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE
Sbjct: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE 180
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSS 240
LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSS
Sbjct: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSS 240
Query: 241 TNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDK 300
TNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDK
Sbjct: 241 TNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDK 300
Query: 301 DLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQE 360
DLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQE
Sbjct: 301 DLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQE 360
Query: 361 REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALN 420
REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALN
Sbjct: 361 REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALN 420
Query: 421 ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAK 480
ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAK
Sbjct: 421 ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAK 480
Query: 481 KNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERS 540
KNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERS
Sbjct: 481 KNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERS 540
Query: 541 QPAAALCRGHSAGRGDEPSIAEGKRLFSFFRKI 573
QPAAALCRGHSAGRGDEPSIAEGKRLFSFFRKI
Sbjct: 541 QPAAALCRGHSAGRGDEPSIAEGKRLFSFFRKI 573
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 255 bits (651), Expect = 9e-68
Identities = 172/504 (34%), Positives = 276/504 (54%), Gaps = 42/504 (8%)
Query: 63 LAAGERPS-DPGEHP---QAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGK 118
L+ G PS D G P + L G GP+ P +L ++QKEKDL+LAA LGK
Sbjct: 14 LSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPE----DLALQLQQKEKDLLLAAELGK 69
Query: 119 ALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQ 178
LLERN+++ RQ E + + ++ E L+QE HELRR R EWE R ELE DV+ L+
Sbjct: 70 MLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALR 129
Query: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
+L Q+ +++ RE++RA+ ELSEQN RL QL++AS+ E++L ++ ALR + +
Sbjct: 130 AQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQA 189
Query: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGH 298
+ + RLESLQ E +ML R+++LE ++ EE + +G ++ + +L+L R+
Sbjct: 190 LAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR 249
Query: 299 DKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELE 358
+ L+L +++ E E + R+LQ +V EL EE LQ + ++ SL SE+ S++ +
Sbjct: 250 EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQG 309
Query: 359 QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL--- 415
Q G D+ +T S ++ + SS + P +
Sbjct: 310 Q------------------------GADAPGDTPTTRSP--KTRKASSPQPSPPEEILEP 343
Query: 416 ---RTALNELKRLIQSIVD--GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKA 470
RT+L+ + L + V+ ++ ++L E+ +L+EE R + ++P E L A
Sbjct: 344 PKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 403
Query: 471 IRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQ 530
+ DRDEA+ K + L+L + ++ SL+ +LL AI+QK+ L+Q+LEAWQDDM VI +Q
Sbjct: 404 LSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQ 463
Query: 531 LMDTHLKERSQPAAALCRGHSAGR 554
L KE S A++ +A R
Sbjct: 464 LRSQRQKELSASASSSTPRRAAPR 487
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 96.3 bits (238), Expect = 7e-20
Identities = 124/509 (24%), Positives = 230/509 (45%), Gaps = 72/509 (14%)
Query: 98 ELLSVIRQKEKDLVLAARLGKAL---LERNQDMSRQYEQMHKELTD-KLEHLE--QEKHE 151
E+ ++ QK K + A L + L ++ Q++ + E+M L + + +H E +E
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 152 LRRRFENREGEWEGRVSEL----------ESDVKQLQDELERQQIHL----READREKSR 197
L++R E EGE + EL +++++ LQD+L L R DREK
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727
Query: 198 AVQELSEQNQRLLDQLSRASEVE---RQLSMQVHALREDFREKNSSTNQHIIRL-ESLQA 253
++EL + Q L D L E E R+ ++ AL+ +E+ SS +Q + +L E A
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 254 EIKMLSDRKREL---------------------EHRLSATLEENDLLQGTVEELQDRVLI 292
E++ L + E E R+ EEN+ LQG EEL+ RV
Sbjct: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ 847
Query: 293 LERQGHDKDLQLHQSQLELQEVRLSCRQLQVKV--------EELTEERSLQSSAATSTSL 344
L+RQ D +++ L++ RQL+ + E ++ R+L++ +
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 345 LSEI--EQSMEAEELEQE---REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMD 399
LS+ EQ +E+L++E +EQLR +L R+ + A ++S
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLR-RLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
Query: 400 ESSETSSAKDVPAGSLRTALNELKR-LIQSIVDGMEPTVTLLSV--EMTALKEE-RDRLR 455
+ E + D R L E++R L + ++ + +T + + EM ++EE RD R
Sbjct: 967 STLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQR 1026
Query: 456 VTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLN---- 511
E ++ L++ ++D + + K+ ++ + ++ M SQL ++++ N
Sbjct: 1027 AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDL 1086
Query: 512 LSQQLEAWQDDMHRVIDRQLMDTHLKERS 540
LS+++ ++ M QL + L+ER+
Sbjct: 1087 LSERISRSREQM-----EQLRNELLQERA 1110
Score = 80.5 bits (197), Expect = 4e-15
Identities = 98/438 (22%), Positives = 193/438 (44%), Gaps = 57/438 (13%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
E L R++EK+ V A R + LE Q Q Q K+L++KL+ ++K +LRR
Sbjct: 878 EALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR--- 934
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRAS 217
+ E E L +++LQ E+ R + E + E E+N+R L +
Sbjct: 935 -LKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRREL------A 987
Query: 218 EVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEEND 277
E++RQL +EK + + +Q E++++ + R+ + L +
Sbjct: 988 EMQRQL-----------KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ 1036
Query: 278 LLQGTVEELQDRVLILERQGHDKD----------LQLHQSQLELQEVRLSCRQLQVKVEE 327
LL+ T+++L+ LE + H KD ++ Q ++EL+E R + L ++
Sbjct: 1037 LLEQTLKDLEYE---LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI-- 1091
Query: 328 LTEERSLQSSAATSTSLLSE--IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGN 385
RS + LL E Q +E +++ ER+ L+ + + Y S
Sbjct: 1092 ---SRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS----- 1143
Query: 386 DSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMT 445
V ++ + E + +++ +L+ + L+R ++ +V ++ E
Sbjct: 1144 -KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD-------EHL 1195
Query: 446 ALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA 505
+L +++D+L + K K Q+++A + D + K ++ EL + +MDM L++
Sbjct: 1196 SLTDQKDQLSLRL--KAMKRQVEEAEEEIDRLESSKKKLQRELEE-QMDMNEHLQGQLNS 1252
Query: 506 IQQKLNLSQQLEAWQDDM 523
+++ L L + DDM
Sbjct: 1253 MKKDLRLKKLPSKVLDDM 1270
Score = 59.3 bits (142), Expect = 9e-09
Identities = 90/402 (22%), Positives = 166/402 (41%), Gaps = 43/402 (10%)
Query: 175 KQLQDELERQQIH--LREA----DREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVH 228
+Q +E +Q ++ L+E D R V + E+ Q L + + +++ Q
Sbjct: 548 QQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTS 607
Query: 229 ALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE-----------ND 277
+++ +K+ T + LQ E+K + K E E R+ A LEE N
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERE-RMRANLEELRSQHNEKVEENS 666
Query: 278 LLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSS 337
LQ +EE + +L ++ EL +V++ Q Q ++ +L ++ S
Sbjct: 667 TLQQRLEESEG--------------ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
Query: 338 AATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSS 397
S + E+ EEL Q ++ L+ L Q L R + A+ + S
Sbjct: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVS 772
Query: 398 M--DESSETSSAKDVPAGSLRTALNELKRLIQSIV---DGMEPTVTLLSVEMTALKEERD 452
E + D +LR ++ E + ++ + + E + + L+EE +
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 453 RLRVTSEDKEPK-EQLQKAIRD--RDEAIAKK--NAVELELAKCRMDMMSLNSQLLDAIQ 507
+L+ SE+ E + QLQ+ I D DEA AK+ E E+ + ++ + +A+
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 508 QKLNLSQQLEAWQDDMHRVIDRQ-LMDTHLKERSQPAAALCR 548
+ L +LEA Q ++ + Q + LKE S+ L R
Sbjct: 893 ARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 88.6 bits (218), Expect = 1e-17
Identities = 98/456 (21%), Positives = 211/456 (46%), Gaps = 83/456 (18%)
Query: 149 KHELRRRFENR-------EGEWEGRVSELESD------------------VKQLQD---E 180
K L++ FE++ + + E R+ +L++D +LQD
Sbjct: 1386 KKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLH 1445
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM---QVHALREDFREK 237
LE QQ+ E ++++ R ELS+ ++ + + +++R+ M + +L++ EK
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEK 1505
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRK--------------RELEHRLSATLEENDLLQGTV 283
+ ++ SL+AE++ +S ++ R+LE ++ EE D GT+
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 284 EELQDRVLILE------RQGHDKDLQLHQSQLELQEVRLSC----RQLQVKVEE------ 327
+ L+ L LE RQ H K+++ E++E R SC +Q++V++EE
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 328 --LTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGN 385
L E+R L+ AT + ++ + E + L ++ ++ + L +A + + HL+ +
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESE-KRLRKDLKRTKALLADA----QLMLDHLKNS 1678
Query: 386 DSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMT 445
+ ++ + E SE + A V A ++ ++ ++ + + ++ T
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKA----------RKAMEVEIEDLHLQIDDIAKAKT 1728
Query: 446 ALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA 505
AL+E+ RL+ E E + +L++ D +E + K A + ++ + L +QL +A
Sbjct: 1729 ALEEQLSRLQ--REKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA 1786
Query: 506 IQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
++K L ++L+A Q + +++ ++D L R +
Sbjct: 1787 NKEKQELQEKLQALQSQV-EFLEQSMVDKSLVSRQE 1821
Score = 84.7 bits (208), Expect = 2e-16
Identities = 101/446 (22%), Positives = 193/446 (43%), Gaps = 48/446 (10%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEK---- 149
S + EL + Q+ KD A++ K L + + Q E++ ++ ++ LEQ K
Sbjct: 1518 SLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ-AGTIQMLEQAKLRLE 1576
Query: 150 HELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRL 209
E+ R + E E R E+E + Q +L++ ++ L E +K + ++E E +L
Sbjct: 1577 MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKL 1636
Query: 210 LDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQ------AEIKMLSDRKR 263
+ + +V R+ LR+D + + + L+ L+ EI L ++
Sbjct: 1637 A---TLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 264 ELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQV 323
E E +A ++ ++ +E+L ++ + + + QL + Q E E++ + Q
Sbjct: 1694 ESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 324 KVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLR 383
+ EL ++ + A S L + + EE +E+++L+ +L QV +L
Sbjct: 1754 DMNELMKKHKA-AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL----- 1807
Query: 384 GNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVE 443
+ SM + S S ++ L T L E +R + V +E + L
Sbjct: 1808 -----------EQSMVDKSLVSR-QEAKIRELETRL-EFER---TQVKRLESLASRLKEN 1851
Query: 444 MTALKEERD-RLRVTSEDKEPKEQLQKAIRDRDE-----------AIAKKNAVELELAKC 491
M L EERD R+ + +KE ++LQ+ +RD E A KK+ +E++L
Sbjct: 1852 MEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESL 1911
Query: 492 RMDMMSLNSQLLDAIQQKLNLSQQLE 517
SL + L A ++ +L +E
Sbjct: 1912 EAANQSLQADLKLAFKRIGDLQAAIE 1937
Score = 70.1 bits (170), Expect = 5e-12
Identities = 91/445 (20%), Positives = 187/445 (42%), Gaps = 45/445 (10%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE 180
++ +++ R ++ ++L KLE E+E++ELR + E R+SEL S++ ++
Sbjct: 1249 VQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSD----RLESRISELTSELTDERNT 1304
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALR----EDFRE 236
E L E+ RA +E+ E Q D L + EV M+ +R +
Sbjct: 1305 GESASQLLDAETAERLRAEKEMKEL-QTQYDALKKQMEVMEMEVMEARLIRAAEINGEVD 1363
Query: 237 KNSSTNQHIIRLESLQAEIKMLSDR-KRELEHRLSATLEENDLLQGTVEELQDRVLILER 295
+ + + ++ E E+ R ++E E +L + L+ + +LQ +R
Sbjct: 1364 DDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQR 1423
Query: 296 QGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE 355
+ + ELQ+ +L QV+ EL E++ + + S + + ++ E
Sbjct: 1424 ALQQLKKKCQRLTAELQDTKLHLEGQQVRNHEL-EKKQRRFDSELSQAHEEAQREKLQRE 1482
Query: 356 ELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL 415
+L++E++ L + + Q+ + G VS ++ + + S S + +
Sbjct: 1483 KLQREKDMLLAEAFSLKQQLEEKDMDIAG--FTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 416 RTALNELKRLI---QSIVDGMEPTVTLLSVEMTALKEERDRLRVT------SEDKEPKE- 465
+ L +L+ + + +D T+ +L L+ E +R+R T S D+E +E
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEA 1600
Query: 466 -------------QLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNL 512
QL++ D+ + + +K +E +LA + + + +++ L
Sbjct: 1601 RQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1660
Query: 513 SQQLEAWQDDMHRVIDRQLMDTHLK 537
++ L A D QLM HLK
Sbjct: 1661 TKALLA---------DAQLMLDHLK 1676
Score = 41.2 bits (95), Expect = 0.003
Identities = 84/392 (21%), Positives = 149/392 (38%), Gaps = 71/392 (18%)
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSS 240
L RQ R+ R VQ+ ++N+ + D + ++V E R K+
Sbjct: 1203 LARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEE 1262
Query: 241 TNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE-----------NDLLQG-TVEELQD 288
Q +LE + E L LE R+S E + LL T E L+
Sbjct: 1263 IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRA 1322
Query: 289 RVLILERQGHDKDL--QLHQSQLELQEVRL-SCRQLQVKVEE--------LTEERSLQSS 337
+ E Q L Q+ ++E+ E RL ++ +V++ L ER+++
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382
Query: 338 AATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSS 397
T L E E +E E +Q + QL +L G+ ADS S
Sbjct: 1383 DFTKKRLQQEFEDKLEVE--QQNKRQLERRL---------------GDLQADSEES---- 1421
Query: 398 MDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKE-ERDRLRV 456
+ AL +LK+ Q + ++ T L + E E+ + R
Sbjct: 1422 ------------------QRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRF 1463
Query: 457 TSEDKEPKEQLQ-------KAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQK 509
SE + E+ Q K R++D +A+ +++ +L + MD+ +++ +
Sbjct: 1464 DSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAEL 1523
Query: 510 LNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
++S Q E+ + + +QL D K + Q
Sbjct: 1524 QDISSQ-ESKDEASLAKVKKQLRDLEAKVKDQ 1554
Score = 38.9 bits (89), Expect = 0.013
Identities = 45/160 (28%), Positives = 64/160 (40%), Gaps = 12/160 (7%)
Query: 102 VIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREG 161
V RQ+ K L RL ER Q ++ E + L + +E L +E+ + R ENRE
Sbjct: 1817 VSRQEAKIRELETRLE---FERTQ--VKRLESLASRLKENMEKLTEERDQ-RIAAENREK 1870
Query: 162 EWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVER 221
E R+ D K+ EL R++ E ++ L NQ L L A +
Sbjct: 1871 EQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIG 1930
Query: 222 QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
L + ED E S N+ +I E L DR
Sbjct: 1931 DLQAAI----ED--EMESDENEDLINSEGDSDVDSELEDR 1964
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 88.6 bits (218), Expect = 1e-17
Identities = 98/456 (21%), Positives = 211/456 (46%), Gaps = 83/456 (18%)
Query: 149 KHELRRRFENR-------EGEWEGRVSELESD------------------VKQLQD---E 180
K L++ FE++ + + E R+ +L++D +LQD
Sbjct: 1386 KKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLH 1445
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM---QVHALREDFREK 237
LE QQ+ E ++++ R ELS+ ++ + + +++R+ M + +L++ EK
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEK 1505
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRK--------------RELEHRLSATLEENDLLQGTV 283
+ ++ SL+AE++ +S ++ R+LE ++ EE D GT+
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 284 EELQDRVLILE------RQGHDKDLQLHQSQLELQEVRLSC----RQLQVKVEE------ 327
+ L+ L LE RQ H K+++ E++E R SC +Q++V++EE
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 328 --LTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGN 385
L E+R L+ AT + ++ + E + L ++ ++ + L +A + + HL+ +
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESE-KRLRKDLKRTKALLADA----QLMLDHLKNS 1678
Query: 386 DSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMT 445
+ ++ + E SE + A V A ++ ++ ++ + + ++ T
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKA----------RKAMEVEIEDLHLQIDDIAKAKT 1728
Query: 446 ALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA 505
AL+E+ RL+ E E + +L++ D +E + K A + ++ + L +QL +A
Sbjct: 1729 ALEEQLSRLQ--REKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA 1786
Query: 506 IQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
++K L ++L+A Q + +++ ++D L R +
Sbjct: 1787 NKEKQELQEKLQALQSQV-EFLEQSMVDKSLVSRQE 1821
Score = 84.7 bits (208), Expect = 2e-16
Identities = 101/446 (22%), Positives = 193/446 (43%), Gaps = 48/446 (10%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEK---- 149
S + EL + Q+ KD A++ K L + + Q E++ ++ ++ LEQ K
Sbjct: 1518 SLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ-AGTIQMLEQAKLRLE 1576
Query: 150 HELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRL 209
E+ R + E E R E+E + Q +L++ ++ L E +K + ++E E +L
Sbjct: 1577 MEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKL 1636
Query: 210 LDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQ------AEIKMLSDRKR 263
+ + +V R+ LR+D + + + L+ L+ EI L ++
Sbjct: 1637 A---TLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 264 ELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQV 323
E E +A ++ ++ +E+L ++ + + + QL + Q E E++ + Q
Sbjct: 1694 ESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 324 KVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLR 383
+ EL ++ + A S L + + EE +E+++L+ +L QV +L
Sbjct: 1754 DMNELMKKHKA-AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL----- 1807
Query: 384 GNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVE 443
+ SM + S S ++ L T L E +R + V +E + L
Sbjct: 1808 -----------EQSMVDKSLVSR-QEAKIRELETRL-EFER---TQVKRLESLASRLKEN 1851
Query: 444 MTALKEERD-RLRVTSEDKEPKEQLQKAIRDRDE-----------AIAKKNAVELELAKC 491
M L EERD R+ + +KE ++LQ+ +RD E A KK+ +E++L
Sbjct: 1852 MEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESL 1911
Query: 492 RMDMMSLNSQLLDAIQQKLNLSQQLE 517
SL + L A ++ +L +E
Sbjct: 1912 EAANQSLQADLKLAFKRIGDLQAAIE 1937
Score = 70.1 bits (170), Expect = 5e-12
Identities = 91/445 (20%), Positives = 187/445 (42%), Gaps = 45/445 (10%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE 180
++ +++ R ++ ++L KLE E+E++ELR + E R+SEL S++ ++
Sbjct: 1249 VQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSD----RLESRISELTSELTDERNT 1304
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALR----EDFRE 236
E L E+ RA +E+ E Q D L + EV M+ +R +
Sbjct: 1305 GESASQLLDAETAERLRAEKEMKEL-QTQYDALKKQMEVMEMEVMEARLIRAAEINGEVD 1363
Query: 237 KNSSTNQHIIRLESLQAEIKMLSDR-KRELEHRLSATLEENDLLQGTVEELQDRVLILER 295
+ + + ++ E E+ R ++E E +L + L+ + +LQ +R
Sbjct: 1364 DDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQR 1423
Query: 296 QGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE 355
+ + ELQ+ +L QV+ EL E++ + + S + + ++ E
Sbjct: 1424 ALQQLKKKCQRLTAELQDTKLHLEGQQVRNHEL-EKKQRRFDSELSQAHEEAQREKLQRE 1482
Query: 356 ELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL 415
+L++E++ L + + Q+ + G VS ++ + + S S + +
Sbjct: 1483 KLQREKDMLLAEAFSLKQQLEEKDMDIAG--FTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 416 RTALNELKRLI---QSIVDGMEPTVTLLSVEMTALKEERDRLRVT------SEDKEPKE- 465
+ L +L+ + + +D T+ +L L+ E +R+R T S D+E +E
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEA 1600
Query: 466 -------------QLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNL 512
QL++ D+ + + +K +E +LA + + + +++ L
Sbjct: 1601 RQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1660
Query: 513 SQQLEAWQDDMHRVIDRQLMDTHLK 537
++ L A D QLM HLK
Sbjct: 1661 TKALLA---------DAQLMLDHLK 1676
Score = 44.3 bits (103), Expect = 3e-04
Identities = 51/180 (28%), Positives = 73/180 (40%), Gaps = 14/180 (7%)
Query: 102 VIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREG 161
V RQ+ K L RL ER Q ++ E + L + +E L +E+ + R ENRE
Sbjct: 1817 VSRQEAKIRELETRLE---FERTQ--VKRLESLASRLKENMEKLTEERDQ-RIAAENREK 1870
Query: 162 EWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVER 221
E R+ D K+ EL R++ E ++ L NQ L L A +
Sbjct: 1871 EQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIG 1930
Query: 222 QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQG 281
L + ED E S N+ +I SLQ + RK +LE E D + G
Sbjct: 1931 DLQAAI----ED--EMESDENEDLI--NSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDG 1982
Score = 41.2 bits (95), Expect = 0.003
Identities = 84/392 (21%), Positives = 149/392 (38%), Gaps = 71/392 (18%)
Query: 181 LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSS 240
L RQ R+ R VQ+ ++N+ + D + ++V E R K+
Sbjct: 1203 LARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEE 1262
Query: 241 TNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE-----------NDLLQG-TVEELQD 288
Q +LE + E L LE R+S E + LL T E L+
Sbjct: 1263 IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRA 1322
Query: 289 RVLILERQGHDKDL--QLHQSQLELQEVRL-SCRQLQVKVEE--------LTEERSLQSS 337
+ E Q L Q+ ++E+ E RL ++ +V++ L ER+++
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382
Query: 338 AATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSS 397
T L E E +E E +Q + QL +L G+ ADS S
Sbjct: 1383 DFTKKRLQQEFEDKLEVE--QQNKRQLERRL---------------GDLQADSEES---- 1421
Query: 398 MDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKE-ERDRLRV 456
+ AL +LK+ Q + ++ T L + E E+ + R
Sbjct: 1422 ------------------QRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRF 1463
Query: 457 TSEDKEPKEQLQ-------KAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQK 509
SE + E+ Q K R++D +A+ +++ +L + MD+ +++ +
Sbjct: 1464 DSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAEL 1523
Query: 510 LNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
++S Q E+ + + +QL D K + Q
Sbjct: 1524 QDISSQ-ESKDEASLAKVKKQLRDLEAKVKDQ 1554
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 80.1 bits (196), Expect = 5e-15
Identities = 94/477 (19%), Positives = 216/477 (45%), Gaps = 39/477 (8%)
Query: 98 ELLSVIRQKEKDLVLAARLGK---ALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRR 154
E +S++ ++ +DL + G+ A+L + Q+ + ++ +LT+KL++ + + +
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 155 RFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLD--- 211
++ E + + + V L+ + L E+ + S+ ++ + + LL
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 212 -QLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLS 270
+ ++ ++++ L +AL++ +E N T Q L+ + A+++ + +LE L
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQ----LDQVTAKLQDKQEHCSQLESHLK 712
Query: 271 ATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE 330
E+ L+ EEL+ ++ LE + Q+ +LQ+ R L+++ EL++
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 331 ERSLQSSAATSTSL----LSEIEQSMEAEELEQERE-QLRLQLWEAYCQVRYLCSHLRGN 385
+ ++ +ST L SE +S++ + +QE E Q+ Q +E Q + H N
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI-QHEELN 831
Query: 386 DSADSAVS--------TDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ----SIVDGM 433
+ + V+ ++ M E S + SL+ + +E ++ Q +I+D +
Sbjct: 832 NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD-L 890
Query: 434 EPTVTLLSVEM-----TALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELEL 488
E T L ++ LKE+++ + ++KE QL+ + E + + +
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN 950
Query: 489 AKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMH-RVIDRQLMDTHLKERSQPAA 544
K + ++L + +QK +Q+EA Q ++ V+ + ++ L+++ AA
Sbjct: 951 EKEEQQLQGNINELKQSSEQK---KKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/431 (21%), Positives = 185/431 (42%), Gaps = 48/431 (11%)
Query: 133 QMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREAD 192
++H EL++K E ++ K EL E E + L+++ KQLQ + E ++ H +
Sbjct: 362 RIHVELSEKGEATQKLKEEL--------SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 193 REKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQ 252
E ++ +L E ++L + R E +RQLS E +K ++L L+
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKE-QRQLSS------EKLMDKEQQVADLQLKLSRLE 466
Query: 253 AEIKMLSDRKRELEHRLSAT----LEENDLLQGTVEELQDRVLILE---RQGHDKDLQLH 305
++K EL+H+L T E+ L Q T +L++ LE RQ DKD ++
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 306 QSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSME------AEELEQ 359
+ LQ+ + + L+ + E+L + + L E +++ E+L+
Sbjct: 527 NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN 586
Query: 360 EREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST-----DSSMDESSETSSAKDVPAG- 413
+ E + + QV+ +HLR ++ T +S ++ES E S D+
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 414 ------SLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDK-EPKEQ 466
S A + +Q+ +D + + E+ + + D++ +DK E Q
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
Query: 467 LQKAIRDRDEAI----AKKNAVELELAKCRMDMMSLNS---QLLDAIQQKLNLSQQLEAW 519
L+ +++ E K +E ++ K D + + + Q L +QQ+ L+ LE
Sbjct: 707 LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
Query: 520 QDDMHRVIDRQ 530
++ + ++ +
Sbjct: 767 ATELSKQLEME 777
Score = 72.8 bits (177), Expect = 8e-13
Identities = 92/427 (21%), Positives = 187/427 (43%), Gaps = 32/427 (7%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE 164
Q +DL +L L R ++S+Q E M KE+ Q+K E + + + E
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 165 GRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLS 224
L+ D + L E + Q L + +Q++ + + L+ +LS + ++S
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 225 MQVHALREDFREKNSSTNQHIIRLES--------LQAEIKMLSDRKRELEHRLSATLEEN 276
+ + +F ++N I+ LE LQ +++ ++EL+ L E +
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926
Query: 277 DLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQS 336
L+ + +Q++++ + + + Q Q + E++ S Q + ++E L E L+
Sbjct: 927 HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE--LKI 984
Query: 337 SAATSTSLLSEIEQSME--AEELEQEREQ---LRLQLWEAYCQVRYLCSHLRGNDSADSA 391
+ T L ++++Q + A+EL E+E+ L+ ++ + L S G +S A
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 392 VSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEER 451
D E + + +D+ S R + +LIQ + T + +A KE++
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLI--SNRNQIGNQNKLIQEL-----KTAKATLEQDSAKKEQQ 1097
Query: 452 DRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRM--DMMSLNSQL----LDA 505
+ R + KE K++++++ K E+E KCR ++ LN +L L++
Sbjct: 1098 LQERCKALQDIQKE---KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 506 IQQKLNL 512
I++ NL
Sbjct: 1155 IKEITNL 1161
Score = 54.7 bits (130), Expect = 2e-07
Identities = 86/483 (17%), Positives = 206/483 (42%), Gaps = 60/483 (12%)
Query: 100 LSVIRQKEKDLVLAARLGKAL-------LERNQDMSRQYEQMHKELTD---KLEHLEQEK 149
++++RQ+ +DL + + K LE+ Q + +Q + +TD +L+ LEQ+
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 150 HE----------LRRRFENREGEWEGRVSELES---DVKQLQDELERQQIHLREADREKS 196
E ++ FE + + +++++S + + L++ E++ L E +++
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 197 RAVQELSE-------------------QNQRLLDQLSRASEVERQ-LSMQVHALREDFRE 236
+Q+L Q Q L+D ++ E E + L + L+ +
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 237 KNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQ 296
++ +Q L E+ + ++L+ ++ ++N L + + + LE +
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324
Query: 297 GHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSL-LSEIEQSMEAE 355
+++ + Q L + L C+QLQ ++ +A+ TSL +E S + E
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRL------------SASETSLHRIHVELSEKGE 372
Query: 356 ELEQEREQL-RLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGS 414
++ +E+L ++ + + + + + + S +++ + G
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 415 LRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDR 474
L E ++L + E V L ++++ L EE+ + +VT+ E + QL K +
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL-EEQLKEKVTN-STELQHQLDKTKQQH 490
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDT 534
E A + + +L + + D+ + Q+ D Q+ NL L+ ++++ +++++ D
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI-SLLEKEREDL 549
Query: 535 HLK 537
+ K
Sbjct: 550 YAK 552
Score = 43.5 bits (101), Expect = 5e-04
Identities = 66/255 (25%), Positives = 109/255 (42%), Gaps = 56/255 (21%)
Query: 106 KEKDLV-----------LAARLGKALLERNQDMSRQYEQMHKELT---DKLEHLEQEKHE 151
KEK+LV + R K + + N+++ + KE+T D + L Q+K E
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 152 LRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLD 211
L +G+ L++ V+Q E QQI + +E+ +E E+ +L
Sbjct: 1175 L-----------QGKADSLKAAVEQ---EKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
Query: 212 QLS-------RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE 264
++ + E E +L+MQ+ AL E+ L +++ E + R E
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNEN--------------LGTVKKEWQSSQRRVSE 1266
Query: 265 LEHRLSATLEENDLLQGTVEELQD-RVLILER--QGHDKDLQLHQSQLELQEVRLSCRQL 321
LE + E +L+ TV+ QD R +LER +G + +L LELQ
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQR---KLDNT 1323
Query: 322 QVKVEEL-TEERSLQ 335
V+EL E +SLQ
Sbjct: 1324 TAAVQELGRENQSLQ 1338
Score = 40.4 bits (93), Expect = 0.004
Identities = 69/323 (21%), Positives = 148/323 (45%), Gaps = 65/323 (20%)
Query: 98 ELLSVIRQKEKDL-VLAARLGKALLERNQ---DMSRQYEQMHKELT---DKLEHLEQEKH 150
EL QK+K + L L A+L++ + + +Q Q +EL +K+ L+
Sbjct: 963 ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 151 ELRRRFENREGEWEGRVSEL---ESDVKQLQDELE---------RQQI--------HLRE 190
+ + F+ + ++ GR SEL D+K ++++L R QI L+
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT 1082
Query: 191 AD--------------REKSRAVQELSEQN----QRLLDQLSRASEVERQLSMQVHALRE 232
A +E+ +A+Q++ ++ + L+++ S+ +E+E Q + +
Sbjct: 1083 AKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142
Query: 233 DFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHR---LSATLEE----NDLLQGTVEE 285
E S + I + +L+ ++L +K EL+ + L A +E+ +L+ V++
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATST--S 343
++ L+++ +K+ +LH S+++ +EV + K EE + ++Q +A +
Sbjct: 1203 EEEE---LKKEFIEKEAKLH-SEIKEKEVGMK------KHEENEAKLTMQITALNENLGT 1252
Query: 344 LLSEIEQSM-EAEELEQEREQLR 365
+ E + S ELE++ + LR
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLR 1275
Score = 37.0 bits (84), Expect = 0.049
Identities = 38/170 (22%), Positives = 78/170 (45%), Gaps = 19/170 (11%)
Query: 101 SVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHE--------- 151
+V ++K +L ++ K E ++ + ++H E+ +K + +KHE
Sbjct: 1185 AVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEK--EVGMKKHEENEAKLTMQ 1242
Query: 152 ---LRRRFENREGEWEG---RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQ 205
L + EW+ RVSELE L+ E+ + ++ ++++ RA+ E +
Sbjct: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN-NQDERRALLERCLK 1301
Query: 206 NQRLLDQL-SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAE 254
+ +++L ++ E++R+L A++E RE S +H L AE
Sbjct: 1302 GEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAE 1351
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 78.6 bits (192), Expect = 1e-14
Identities = 110/474 (23%), Positives = 197/474 (41%), Gaps = 71/474 (14%)
Query: 120 LLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQD 179
L ER D + Q+H EL D L Q + E + +WEG+ + LES++ +L +
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEE--------KSKWEGKQNSLESELMELHE 1320
Query: 180 ELERQQIHLREADREKSRA------VQELSEQNQRLLDQLSRASEVERQLSMQVHALRED 233
+ Q LR A+ ++ A +Q E ++ L A R + L ED
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 234 FRE-------KNSSTNQHIIRLESLQ-------AEIKMLSDRKRELEHRLSATLEENDLL 279
R KN R ++LQ A+ K L + L L+ EE + L
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
Query: 280 QGTVEELQDR---------VLILERQGHDKDLQLHQSQL-ELQEVRLSCRQLQVKVEELT 329
+G ++EL+ + +L L+ + ++++ L Q Q+ EL++ R L + V+E
Sbjct: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500
Query: 330 EE--------RSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYL-CS 380
++ R L+ T ++L Q +E E+ +Q E R Q+ + Q+ L C
Sbjct: 1501 QKLTVQREQIRELEKDRETQRNVLE--HQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 381 HLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ---SIVDGMEPTV 437
L ++ + E + V L L E + +Q S + +E
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS 1618
Query: 438 TLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAI--AKKNAVELELAKCRM-- 493
T+L+ E+ +ERD+ E K +EQ+++ R ++ ++ EL L K R+
Sbjct: 1619 TVLAREL----QERDQ-----EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 494 --DMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAA 545
D + +++L+ +++ LS + + RQLM +E P+ A
Sbjct: 1670 LEDQRTRQTKILEEDLEQIKLSLR----ERGRELTTQRQLMQERAEEGKGPSKA 1719
Score = 69.3 bits (168), Expect = 9e-12
Identities = 90/430 (20%), Positives = 178/430 (41%), Gaps = 46/430 (10%)
Query: 125 QDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQ 184
+++ Q E LT LE+ EL+ + ++ + E + L ++++ E++ Q
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQ-SSQIHDLESHSTVLARELQERDQEVKSQ 1635
Query: 185 QIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQH 244
+ + E R+K Q+L ++Q L+ Q R +E Q + Q L ED + S +
Sbjct: 1636 REQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRE- 1694
Query: 245 IIRLESLQAEIKMLSDRKRE-----------LEHR---LSATLEENDLLQGTVEELQDRV 290
R L + +++ +R E LEH L +E + Q + ELQ+
Sbjct: 1695 --RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 291 LILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE-----ERSLQSSAATSTSLL 345
LE+Q ++ ++ L L + LQ +++E E E+SLQS + L
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812
Query: 346 SEIEQSMEAEELEQEREQ------------LRLQLWEAYCQVRYLCSHLRGNDSADSAVS 393
++ +Q +EA + EQ++ Q L+ L +A+ ++ L+ D + A
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ--DHKEQARR 1870
Query: 394 TDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDR 453
+ + A + G LR E ++ + ++ VE AL++ +
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
Query: 454 LRVTSEDKEP-----KEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQ 508
+ ++++ + + Q + + A A+ A++ L K + LL +
Sbjct: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL----E 1986
Query: 509 KLNLSQQLEA 518
+ LS+ LEA
Sbjct: 1987 QAELSRSLEA 1996
Score = 66.2 bits (160), Expect = 8e-11
Identities = 133/573 (23%), Positives = 238/573 (41%), Gaps = 90/573 (15%)
Query: 50 GELELA----LEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSV--- 102
GEL++A L+E LALL + ++ E + G + E + ELLS+
Sbjct: 1409 GELKVAQGKALQENLALLT--QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 103 ------------IRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKH 150
I++ EK + L A+ ER Q ++ Q EQ+ + LE+++
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE--------LEKDRE 1518
Query: 151 ELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLL 210
R E++ E E + +ES Q+QD L++Q + L EL E + ++
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQD-LKKQLVTL-------ECLALELEENHHKME 1570
Query: 211 DQLSRASEVERQLSMQVHALRE---DFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEH 267
Q E+E Q Q AL D E++ ++ L++ +L+ +E +
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 268 RLSATLEENDLLQGTVEEL------QDRVLILERQGHD--KDLQLHQSQL---ELQEVRL 316
+ + E+ + LQ E L +D+ L+L+++ +D + Q+++ +L++++L
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 317 SCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVR 376
S R+ + ELT +R L A S+ ++ LE + LR + E CQ
Sbjct: 1691 SLRE---RGRELTTQRQLMQERAEEGKGPSKAQRG----SLEHMKLILRDKEKEVECQQE 1743
Query: 377 YLCSHLRGNDSADSAV-STDSSMDESSETSSAKDVPAGSLRTALNELK-------RLIQS 428
++ D + + + E+S S ++ L+ L E + + +QS
Sbjct: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803
Query: 429 IVDGMEPTVTLLSVEMTALKEERDRLRVTSED-KEPKEQLQKAIRDRDEAIAKKNA---- 483
+D + + E+ AL++E+ + + E KE + LQ A+ + +++
Sbjct: 1804 QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863
Query: 484 -------VELELAKCRMDMMSLNSQLLD-----AIQQKLNLS-QQLEAWQDDMHRVIDRQ 530
+E ELA + +L L D Q+K L+ QQ A Q H V R
Sbjct: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923
Query: 531 LMDTH------LKERSQPAAALCRGHSAGRGDE 557
L D+ LKER Q AL + R E
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956
Score = 65.1 bits (157), Expect = 2e-10
Identities = 108/478 (22%), Positives = 192/478 (40%), Gaps = 76/478 (15%)
Query: 127 MSRQYEQMHK---ELTDKLEHLEQEKHELRR-------RFENREGEWEGRVSELESDVKQ 176
+S++ E + K EL +LE LEQE LRR + ++ +G+ E + EL V++
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 177 L-------------QDELERQQIHLREADREKSRAVQELSEQNQ-RLLDQLSRASEVERQ 222
Q E + I LREA E S EL Q Q + L+RA + +
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREA-LESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 223 LSMQVHALREDFREKNSST-----------------NQHIIRLESLQAEI---------- 255
LS + L+ + + ++ NQ +++LE +
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
Query: 256 -KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEV 314
L E E R A E+N L+ +++ ++ L+ D + + Q +L E
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Query: 315 RLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQ 374
R ++E+L +E Q +L+ Q EA E+ ++RLQ E Q
Sbjct: 700 RHQQEAATTQLEQLHQEAKRQE------EVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 375 VRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGME 434
L L+G SA + +SS+ E+ + +S +V G L + + + + I +
Sbjct: 754 --DLAEQLQGLSSAKELL--ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
Query: 435 PTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMD 494
L E + ++ERD + EQ K ++ +A +K +L K +
Sbjct: 810 CLKLELDTERSQAEQERD---AAARQLAQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKE 865
Query: 495 MMSLNSQLLDAIQ----QKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCR 548
+L A++ +K+ L +L+ Q +M + +ER+Q +ALC+
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI-----QAQREEERTQAESALCQ 918
Score = 64.7 bits (156), Expect = 2e-10
Identities = 99/501 (19%), Positives = 202/501 (40%), Gaps = 97/501 (19%)
Query: 109 DLVLAARLGKALLERNQDMSRQYEQMHK---ELTDKLEHLEQEKHELRRRFENREGEWEG 165
DL A + +AL E+N + Q ++ + EL L +++EK E++++ + E
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQE----------LSEQNQRLLDQLSR 215
++LE QL E +RQ+ L A +EK V+E + Q L +QL
Sbjct: 706 ATTQLE----QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 216 ASEVERQLSMQVHALREDFREKNSSTNQHIIRLES-------LQAEIKMLS--------- 259
S + L + ++ + Q +++++ +Q E++ L
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
Query: 260 -----------------DRKRELEHRLSATLEENDLLQGTVE--------ELQDRVLILE 294
+ K LE + +A +E + L+ E EL + LE
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
Query: 295 RQGHDKDLQLHQSQLELQEVRLSCRQLQVKVE--------ELTEER--------SLQSSA 338
R+ + +++L + Q E++ ++ + + + E E +ER Q
Sbjct: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 339 ATSTSLLSEIEQSMEAEELEQEREQ--LRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDS 396
A ++ L + Q M+ ++L+++ L+ QL EA +++ R + +A S+
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
Query: 397 SMDESSETSSAKDVPAGSLRTALNELKRLI-QSIVDGMEPTVTLLSVE----------MT 445
D+ +D+ S A ++ +RL+ Q + + + T ++
Sbjct: 1002 LQDKMDLQKQVEDLK--SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 446 ALKEERDRLRVTSEDKEPKEQ--------LQKAIRDRDEAIAKKNAVELELAKCRMDMMS 497
+L E+ RL V E ++Q +Q+A ++ E A+ + E+ + D ++
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 498 LNSQLLDAIQQKLNLSQQLEA 518
+QLL+ ++ QQL A
Sbjct: 1120 QEAQLLEELEASHITEQQLRA 1140
Score = 64.7 bits (156), Expect = 2e-10
Identities = 107/489 (21%), Positives = 191/489 (39%), Gaps = 111/489 (22%)
Query: 116 LGKALLERNQDMSRQYEQMHK------ELTDKLEHLEQEKHELRRRFENREGEWEGRVSE 169
L + L ER+Q++ Q EQ+ + LT LE +QE + R + E + +
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680
Query: 170 LESDVKQL--------------------------------QDELERQQIHLR------EA 191
LE D++Q+ + LE ++ LR E
Sbjct: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
Query: 192 DREKSRAVQELSEQNQRLLDQLSR----ASEVERQLSMQVHALREDFREKNSSTNQHIIR 247
+E +QEL +Q ++ L L R S + Q ++ L++ +E + Q ++
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE---AREQGELK 1797
Query: 248 LESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQS 307
+SLQ+++ + + L A +E QG E ++++ L+ + L +
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Query: 308 QLELQEVRLSCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRL 366
ELQ+ + R+L+ EEL E R +Q+ L E+ + AE EQE+ L L
Sbjct: 1858 HGELQDHKEQARRLE---EELAVEGRRVQA--------LEEVLGDLRAESREQEKALLAL 1906
Query: 367 Q----------------LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDV 410
Q L +++ Q + + L+ D A+ +S E A
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQAV---LKERDQELEALRAESQSSRHQE--EAARA 1961
Query: 411 PAGSLRTALNELKRLIQ----------SIVDGMEPTVTLLSVEMTAL----KEERDRLRV 456
A +L+ AL + +Q + +E + L + A ++ + LR+
Sbjct: 1962 RAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021
Query: 457 TSED--------KEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQ 508
+ +E +QLQ+A+ RDE + + E L K + N IQ+
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN-----MIQE 2076
Query: 509 KLNLSQQLE 517
K NL Q+ E
Sbjct: 2077 KQNLGQERE 2085
Score = 63.5 bits (153), Expect = 5e-10
Identities = 112/501 (22%), Positives = 211/501 (42%), Gaps = 66/501 (13%)
Query: 46 PGGSGELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGP-QPPPSQD--PELLSV 102
P GSG ++ +L LL A + + H +++ + G + QD EL ++
Sbjct: 232 PNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSAL 291
Query: 103 IRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFEN---- 158
+ Q +K ++ KAL E + + + ++ + + ++EK L++ ++
Sbjct: 292 LTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV 351
Query: 159 --REGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLD---QL 213
EG+ + S E+ ++ D Q ++AD+ + L+ + Q + D QL
Sbjct: 352 MVEEGDNIAQGSGHENSLEL--DSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL 409
Query: 214 SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
+ E L Q + + E+ + Q RL+ L E L+ + +L+ + +
Sbjct: 410 AGCQEAVNLLQQQ----HDQWEEEGKALRQ---RLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERS 333
+E +LLQ EEL+ ++ +LE++ +L + +ELQ L Q + EE EE
Sbjct: 463 KERELLQKAREELRQQLEVLEQEA----WRLRRVNVELQ---LQGDSAQGQKEEQQEELH 515
Query: 334 LQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRG-------ND 386
L A L E+ +EA++ E E + L+ EA SHL G +
Sbjct: 516 L---AVRERERLQEMLMGLEAKQSESLSELITLR--EA-----LESSHLEGELLRQEQTE 565
Query: 387 SADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSI-VDGMEPTVTLLSVE-- 443
+ + S+ E S + + LR A +L L +++ +D + LL +E
Sbjct: 566 VTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 444 -------MTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNA-VELELAKCRMDM 495
M A ++ R+ L+V + E R EA+ +KN +E +L K
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAE----------KRREALWEKNTHLEAQLQKAEEAG 675
Query: 496 MSLNSQLLDAIQQKLNLSQQL 516
L + L D ++K + ++L
Sbjct: 676 AELQADLRDIQEEKEEIQKKL 696
Score = 63.5 bits (153), Expect = 5e-10
Identities = 112/527 (21%), Positives = 224/527 (42%), Gaps = 70/527 (13%)
Query: 51 ELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPE---LLSVIRQKE 107
ELE+ L+E+ + A + + E + AE A Q + E LL + Q +
Sbjct: 886 ELEMRLKEQQTEMEAIQAQRE-------EERTQAESALCQMQLETEKERVSLLETLLQTQ 938
Query: 108 KDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRV 167
K+L A++ + L + + + ++ L +L+ ++E E R+ + +
Sbjct: 939 KELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
Query: 168 SELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQV 227
S L D LQ ++E + L D + QE+ E+ L + + ++++L
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK----LRETQEYNRIQKELE--- 1051
Query: 228 HALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQ 287
REK S T + L + + +L + + LSA ++ QG +EL
Sbjct: 1052 -------REKASLT----LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEER---SLQSSAATSTSL 344
++ +L ++ +K+ + +L E +++ +TE++ SL + A + L
Sbjct: 1101 AQMELLRQEVKEKEADFLAQEAQLLE--------ELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 345 ---LSEIEQSMEAEELEQE---REQLRLQLWEAYCQVRYLCSHL--------RGNDSADS 390
L E +EA EQ+ + Q + QL Y ++ + G DSA S
Sbjct: 1153 QLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPS 1212
Query: 391 AVSTDSSMDESSETSSAKDVP------AGSLRTALNELKRLI---QSIVDGMEPTVTLLS 441
+ D++ S K P A ++ +AL++L + + Q D + V L
Sbjct: 1213 VWGLEP--DQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLE 1270
Query: 442 VEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQ 501
+T + E+ ++ +D + QL + ++ + K+N++E EL + M SL S+
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQ--RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 502 LLDAIQQKLNLS---QQLEAWQDDMHRVIDRQLMDTHLKERSQPAAA 545
L A Q++ + L+A ++++ ++ L ++ R+Q +AA
Sbjct: 1329 LRRAELQRMEAQGERELLQAAKENLTAQVE-HLQAAVVEARAQASAA 1374
Score = 62.8 bits (151), Expect = 8e-10
Identities = 103/461 (22%), Positives = 183/461 (39%), Gaps = 58/461 (12%)
Query: 57 EEELALLAAGERPSDPGEHPQAEPGSLAEG----AGPQPPPSQDPELLSVIRQKEKDLVL 112
E+E ALLA ++ ++ + + E +L + Q+ E L Q +
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
Query: 113 AAR---------LGKA----------LLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
AAR LGKA LLE+ ++SR E L L+ + +L
Sbjct: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQ-AELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 154 RRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQL 213
+EGE + + + DV+QLQ L ++ LR + + L+++ Q + Q
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
Query: 214 SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
+ ER+ ++ L + RE ++L Q E ++L R+ + + L A
Sbjct: 2077 KQNLGQERE-EEEIRGLHQSVRE---------LQLTLAQKEQEILELRETQQRNNLEALP 2126
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEE-R 332
+ + +E Q D + Q EL+ ++ + RQ + + E E+ +
Sbjct: 2127 HSH------------KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQ 2174
Query: 333 SLQSSAA---TSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSAD 389
L S A S S L E+ ++A LE++ EQ RLQ E R L + A
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ-DELELTRRALEKERLHSPGAT 2233
Query: 390 SAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKE 449
S S ++ + V A + K+ + ++ ++ V L ++ + L+
Sbjct: 2234 STAELGSRGEQGVQLGEVSGVEAEPSPDGME--KQSWRQRLEHLQQAVARLEIDRSRLQR 2291
Query: 450 ERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAK 490
+LR T E E + + K EA+ A LE++K
Sbjct: 2292 HNVQLRSTLEQVERERRKLKR-----EAMRAAQAGSLEISK 2327
Score = 30.8 bits (68), Expect = 3.5
Identities = 82/350 (23%), Positives = 140/350 (40%), Gaps = 61/350 (17%)
Query: 223 LSMQVHALREDFRE---------KNSSTNQH--IIRLESLQAEIKMLSDRKRELEHRLSA 271
L QV AL++ E KNS Q + LQA++ +ELE RL A
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 272 TLEENDLLQGTVEELQ-DRVLIL---ERQGHDKDLQLH-QSQLELQEVRLSCRQLQVKVE 326
T VEE D +L+ E+Q + +++ Q +L +++ + + L+ VE
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVE 139
Query: 327 ELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGND 386
+LT + S ++EQ L+ E +L L LW R H
Sbjct: 140 KLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL-LSLWREVVTFR---RHFLEMK 195
Query: 387 SADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQS-------IVDGMEPTVTL 439
SA TD + E + +GSL T L QS +DG EP L
Sbjct: 196 SA-----TDRDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 440 LSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDR-DEAIAKKNAVELELAKCRMDMMSL 498
L + T ++L+K +R E I K+ +LE A+ + + L
Sbjct: 248 LLLAKT-------------------QELEKEAHERSQELIQLKSQGDLEKAELQDRVTEL 288
Query: 499 NSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCR 548
++ L + +Q + + ++A ++ + ++++T+ E + A+L R
Sbjct: 289 SALLTQSQKQNEDYEKMIKALRETV------EILETNHTELMEHEASLSR 332
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 78.6 bits (192), Expect = 1e-14
Identities = 93/452 (20%), Positives = 198/452 (43%), Gaps = 46/452 (10%)
Query: 95 QDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQ----YEQMHKELTDKLEHLEQEKH 150
Q E L ++EK L + K LE + ++++ E ++L ++L+ + E
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 151 ELRRRFENREG---EWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQ 207
+L+ + E+ + +++ ++ EL++ +++L++E+E ++ + ++++S +EL E ++
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149
Query: 208 RLLDQ---LSRASEVERQLSMQVHALREDFREKN--------SSTNQHIIRLESLQAEIK 256
RL + S E+ ++ + LR D E + +H + L +I
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209
Query: 257 MLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRL 316
L K++LE S E D L ++E + LE+ + QL +++ + +E++
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 317 SCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQV 375
S +L + L TE L S++S++ +S +A Q+ E+L+ QL E
Sbjct: 1270 SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA--FTQQTEELKRQLEE----- 1322
Query: 376 RYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEP 435
+ N A + S+ D E + L+ AL++
Sbjct: 1323 ----ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS----------- 1367
Query: 436 TVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDM 495
V K E D ++ T E +E K++L + ++D +E + NA L K + +
Sbjct: 1368 -----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL 1422
Query: 496 MSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVI 527
L+ +++ +L+ L+ Q + +V+
Sbjct: 1423 QGEVEDLMVDVERANSLAAALDKKQRNFDKVL 1454
Score = 69.3 bits (168), Expect = 9e-12
Identities = 102/474 (21%), Positives = 187/474 (39%), Gaps = 61/474 (12%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENRE---GEWEGRVSELESDV 174
K + ER +D E+++ ELT K LE E EL++ ++ E + E E+ V
Sbjct: 921 KEVTERAEDE----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 976
Query: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234
K L +EL + + REK + L E +Q+ LD L + L+ L +
Sbjct: 977 KNLTEELSGLDETIAKLTREK----KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294
+ SS Q + L+ +++ KR+LE L E L+ ++L +R+
Sbjct: 1033 EDLESSLEQE----KKLRVDLER---NKRKLEGDLKLAQESILDLENDKQQLDERL---- 1081
Query: 295 RQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEEL---TEERSLQSSAATSTSLLSEIEQS 351
KD + Q Q ++++ + Q Q K++EL EE + A +T +E ++S
Sbjct: 1082 ---KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS 1138
Query: 352 MEAEELEQERE------------------------QLRLQLWEAYCQVRYLCSHLRGNDS 387
A ELE+ E +LR L EA Q + + LR
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR-KKH 1197
Query: 388 ADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD---GMEPTVTLLSVEM 444
ADS +D + + +++L ++S+ +E L ++
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257
Query: 445 TALKEERDRL-RVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLL 503
+ + + + + R SE K +LQ + + +K ++ +L++ + +L
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Query: 504 DAIQQKLNLSQQL-EAWQDDMHRVIDRQLMDTHLKERSQPAAALCRGHSAGRGD 556
++++ L A Q H D L+ +E + A L R S +
Sbjct: 1318 RQLEEENKAKNALAHALQSSRH---DCDLLREQYEEEQEGKAELQRALSKANSE 1368
Score = 58.5 bits (140), Expect = 2e-08
Identities = 98/481 (20%), Positives = 189/481 (39%), Gaps = 52/481 (10%)
Query: 104 RQKEKDLVLAARLGKALLERNQD---MSRQYEQMHK---ELTDKLEHLEQEKHELRRRFE 157
RQ E++ L AL D + QYE+ + EL L E + R ++E
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1377
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQ-----IHLREADREKSRAVQELSEQNQRLLDQ 212
+ R ELE K+L L+ + ++ + A EK++ Q L + + L+
Sbjct: 1378 TDAIQ---RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK--QRLQGEVEDLMVD 1432
Query: 213 LSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLE-------SLQAEIKMLSDRKREL 265
+ RA+ + L + + E + + LE SL E+ L + E
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492
Query: 266 EHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKV 325
+L EN L+ + +L +++ + H+ + Q +LE +++L+ + + +
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL 1552
Query: 326 EELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAY--------CQVRY 377
E EE + T + SEI++ + E ++E EQL+ +VR
Sbjct: 1553 EH--EEAKILRIQLELTQVKSEIDRKI--AEKDEEIEQLKRNYQRTVETMQSALDAEVRS 1608
Query: 378 LCSHLR-----GNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDG 432
+R D + + + +++ET G L+ L ++ D
Sbjct: 1609 RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED- 1667
Query: 433 MEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQL-QKAIRDRDEAIAKKNAVELEL--- 488
++ + ++ L+ E + LR T E E +L ++ + D +E + + L
Sbjct: 1668 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHT 1727
Query: 489 -AKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALC 547
K D+M L S++ DA + N ++ + + D +M LK+ +A L
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEEKAK------KAITDAAMMAEELKKEQDTSAHLE 1781
Query: 548 R 548
R
Sbjct: 1782 R 1782
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/160 (23%), Positives = 77/160 (48%), Gaps = 6/160 (3%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE 164
+K K + A + L++ QD S E+M K L ++ L+ H L + +
Sbjct: 1754 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ---HRLDEAEQLALKGGK 1810
Query: 165 GRVSELESDVKQLQDELERQQIHLREAD---REKSRAVQELSEQNQRLLDQLSRASEVER 221
++ +LE+ +++L+ ELE +Q E+ R+ R V+EL+ Q++ + R ++
Sbjct: 1811 KQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVD 1870
Query: 222 QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
+L ++V + + E + N H+ + Q E++ +R
Sbjct: 1871 KLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Score = 45.8 bits (107), Expect = 1e-04
Identities = 80/391 (20%), Positives = 164/391 (41%), Gaps = 41/391 (10%)
Query: 159 REGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSE-------QNQRLLD 211
+ E E ++ ++ + ++ +DEL + + +E + + VQE ++ +++ LLD
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 212 QLSRASEVER---QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHR 268
R ++ + QL ++ + E ++ + + L+ E L +LE
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 269 LSATLEENDLLQGTVEELQDRVLILERQGHDKDL-QLHQSQLELQEVRLSCRQLQVKVEE 327
L+ +E + V+ L + E G D+ + +L + + LQE Q +++
Sbjct: 962 LAKVEKEKHATENKVKNLTE-----ELSGLDETIAKLTREKKALQEAH------QQALDD 1010
Query: 328 LTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDS 387
L E +S + S L + + +E+ LEQE+ +LR+ L R L L+ +
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLES-SLEQEK-KLRVDLER---NKRKLEGDLK--LA 1063
Query: 388 ADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRL---IQSIVDGMEPTVTLLSVEM 444
+S + ++ + E KD L++ + + + L Q + ++ + L E+
Sbjct: 1064 QESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI 1123
Query: 445 -----TALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDM--MS 497
T K E+ R E +E E+L++A I E E K R D+ +
Sbjct: 1124 EAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183
Query: 498 LNSQLLDAIQQKLNLSQQLEAWQ--DDMHRV 526
L + + A +K + E + D++ RV
Sbjct: 1184 LQHEAMVAALRKKHADSVAELGEQIDNLQRV 1214
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/277 (20%), Positives = 108/277 (38%), Gaps = 56/277 (20%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
E L+++ ++ L +A LE+ + + EQ + ++++ L + L +
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRAS 217
+LE+D+ QLQ E+E R A+ + +A+ + + + L + ++
Sbjct: 1730 -----------KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778
Query: 218 EVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEEND 277
+ER + + +D + + Q + L+ + +I+ L R RELE L ++N
Sbjct: 1779 HLER-MKKNLEQTVKDLQHRLDEAEQ--LALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 278 ----------------------------LLQGTVEELQDRVLILERQGHDKDLQLH---- 305
LQ V++LQ +V +RQ + D Q +
Sbjct: 1836 ESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLT 1895
Query: 306 -----QSQLELQEVRLSCRQLQV-----KVEELTEER 332
Q +LE E R + QV K + T R
Sbjct: 1896 KFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 78.6 bits (192), Expect = 1e-14
Identities = 100/397 (25%), Positives = 179/397 (45%), Gaps = 56/397 (14%)
Query: 141 KLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLRE----ADREKS 196
K LE+E H+L ++ E + + E R + D++ L +EL R++ L+ +K+
Sbjct: 495 KCGELEKENHQLSKKIEKLQTQLE-REKQSNQDLETLSEELIREKEQLQSDMETLKADKA 553
Query: 197 RAVQELSEQNQRLLDQLSRASEVERQLS-MQVHALREDFREKNSSTNQHII----RLESL 251
R +++L ++ D L+RA R+ S + A +D ++N + +Q + +L L
Sbjct: 554 RQIKDLEQEK----DHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQL 609
Query: 252 QAEIKML----------SDRKRELEHRLSATLEENDLLQGTVEELQ---DRVLILERQGH 298
+ E + L +R +LE L EEN L V L+ ++V LE +
Sbjct: 610 EFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQ 669
Query: 299 DKDLQ---LHQSQLELQEVRLSCRQL-----QVKVEELTEERSLQSSAATSTSLLSEIEQ 350
L+ L +S LQ V L L Q+ E L R +++ TST L +
Sbjct: 670 GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLA---QM 726
Query: 351 SMEAEELEQEREQLR--LQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAK 408
E ++LE+E+E+LR + L +A + + SA++ + S++ SS +
Sbjct: 727 ERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN-LRLQQSLESSSHKTQTL 785
Query: 409 DVPAGSLRTALNELKRLIQSI------VDGMEPTVTLLSVEMTALKEERDRLRVTSEDKE 462
+ G L L+R ++++ ++G E L E+ L E+D+ + E K
Sbjct: 786 ESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL--EKDKKLLEKEAKR 843
Query: 463 PKEQLQKAIRDRDEAIAKKNAVE-------LELAKCR 492
+Q++ D++ AK +AVE ELA+CR
Sbjct: 844 LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCR 880
Score = 60.1 bits (144), Expect = 5e-09
Identities = 92/387 (23%), Positives = 155/387 (40%), Gaps = 66/387 (17%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
+LL + +K + L L+ + A R Q + L +L LE E+ LRR E
Sbjct: 745 DLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLE 804
Query: 158 -------NREGEWEGR------VSELESDVKQLQDELER--QQIHLREADREKSRAVQEL 202
EG + R V++LE D K L+ E +R QQ+ L++A + S A
Sbjct: 805 ALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSA 864
Query: 203 SEQNQRLLD-QLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
E+ R LD +L+R + +L L +D R+ H L +L+ ++ + +
Sbjct: 865 VEKESRALDKELARCRDAAGKLK----ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLK 920
Query: 262 KRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQL 321
++L L +E LE+ G +++L L + S
Sbjct: 921 SQQLSSELDKLSQE-----------------LEKVGLNRELLLQEDD--------SGSDT 955
Query: 322 QVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSH 381
+ K+ E E +L+++ A + +E ME E+ L QL ++ C
Sbjct: 956 KYKILEGRNESALKTTLAMKEEKIVLLEAQME------EKASLNRQLESELQMLKKECET 1009
Query: 382 LRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLS 441
LR N E ++ PAG +TA + + E T+ LL
Sbjct: 1010 LRQNQG------------EGQHLQNSFKHPAG--KTAASHQGKEAWG-PGHKEATMELLR 1054
Query: 442 VEMTALKEERDRLRVTSEDKEPKEQLQ 468
V+ A++ ER+ + +E + KEQLQ
Sbjct: 1055 VKDRAIELERNNAALQAEKQLLKEQLQ 1081
Score = 55.8 bits (133), Expect = 1e-07
Identities = 105/482 (21%), Positives = 189/482 (39%), Gaps = 81/482 (16%)
Query: 103 IRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGE 162
++ K DL L K +E + + E K+ ++ HL E +L + + +
Sbjct: 390 LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDAS 449
Query: 163 WEGRVSELE--SDVKQLQDELERQQIH-----LREAD---REKSRAVQELSEQNQRL--- 209
+ V EL + + L+ E E Q + LR+A E EL ++N +L
Sbjct: 450 RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKK 509
Query: 210 LDQLSRASEVERQLSMQVHALREDF-REKNSSTNQHIIRLESLQAE-IKMLSDRKRELEH 267
+++L E E+Q + + L E+ REK + +E+L+A+ + + D ++E +H
Sbjct: 510 IEKLQTQLEREKQSNQDLETLSEELIREKEQLQSD----METLKADKARQIKDLEQEKDH 565
Query: 268 ------------------RLSATLEENDLLQGTVEELQDRVLILE----------RQGHD 299
R+ +EN L TV E ++ LE Q +
Sbjct: 566 LNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKE 625
Query: 300 KDLQLHQSQLELQEVRLSCRQLQVKVEELT-----------EERSLQSSAATSTSLLSEI 348
K + + + ELQ ++ +L KV L E + LQ T L +
Sbjct: 626 KGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTL 685
Query: 349 EQ-SMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
+ S++ E LE++ +QL + E +R L +R + + + ++ E +
Sbjct: 686 QNVSLQLEGLERDNKQLDAENLE----LRRLVETMRFTSTKLAQMERENQQLEREKEELR 741
Query: 408 KDVP------------AGSLRTALNELKRLIQSIVDGMEPTVTL------LSVEMTALKE 449
K+V S ++ E RL QS+ T TL L E AL+
Sbjct: 742 KNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRR 801
Query: 450 ERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQK 509
+ + LR+ + E E+ +KA+ + K + + AK + L +LD K
Sbjct: 802 DLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAK 861
Query: 510 LN 511
L+
Sbjct: 862 LS 863
Score = 51.2 bits (121), Expect = 3e-06
Identities = 107/496 (21%), Positives = 201/496 (40%), Gaps = 89/496 (17%)
Query: 59 ELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGK 118
EL + ER +HP + S + + P P S E ++ L + K
Sbjct: 208 ELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE-------DKQHLAVELADTK 260
Query: 119 ALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQ 178
A L R + +EL DK E L +HE+ + V +LQ
Sbjct: 261 ARLRR----------VRQELEDKTEQLVDTRHEV------------------DQLVLELQ 292
Query: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
+++++ I L AD +RA ++ + L ++ +R +E +L+ +EK
Sbjct: 293 -KVKQENIQLA-ADARSARAYRD---ELDSLREKANRVERLELELTR--------CKEKL 339
Query: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGH 298
+ + R+E L+ + +L + K LE +L+A D V EL+ L L+ + H
Sbjct: 340 HDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGD----KVHELEKENLQLKSKLH 395
Query: 299 DKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQ-SMEAEEL 357
D +L + ++E+ + V E+ +++S+ SA L E+EQ S A+
Sbjct: 396 DLELDRDTDKKRIEEL-----LEENMVLEIAQKQSMNESA----HLGWELEQLSKNADLS 446
Query: 358 EQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRT 417
+ R+ +L E C + + N S S + + ++S + G L
Sbjct: 447 DASRKSFVFELNE--CASSRILKLEKENQSLQSTI---QGLRDASLVLEESGLKCGELEK 501
Query: 418 ALNELKRLIQSIVDGME------PTVTLLSVEMTALKEE---------RDRLRVTSEDKE 462
++L + I+ + +E + LS E+ KE+ D+ R + ++
Sbjct: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQ 561
Query: 463 PKEQLQKA---IRDRDE--AIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
K+ L +A +R+R + + A+ VE E + N +L +K L + LE
Sbjct: 562 EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLE 621
Query: 518 AWQDDMHRV--IDRQL 531
++ R ++R+L
Sbjct: 622 QAKEKGERAEKLEREL 637
Score = 50.8 bits (120), Expect = 3e-06
Identities = 61/241 (25%), Positives = 99/241 (41%), Gaps = 41/241 (17%)
Query: 124 NQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSE----------LESD 173
N+ + RQ EQ LT E L Q+ L E + E+E + + LE +
Sbjct: 1150 NESLQRQQEQ----LTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELE 1205
Query: 174 VKQLQD----------ELERQQIHL---READREKSRAVQELSEQNQRLLDQLSRASEVE 220
K+L + ELE ++ L REA +++ R +NQRL +L R + +
Sbjct: 1206 HKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLH 1265
Query: 221 RQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKR-------------ELEH 267
QL + L +E +S N + L QA L ++ + EL
Sbjct: 1266 HQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLS 1325
Query: 268 RLSATL-EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVE 326
RL L EEN L ++ L + +L Q + Q H+ Q + + + R+ + K+E
Sbjct: 1326 RLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLE 1385
Query: 327 E 327
E
Sbjct: 1386 E 1386
Score = 43.1 bits (100), Expect = 7e-04
Identities = 93/428 (21%), Positives = 166/428 (38%), Gaps = 62/428 (14%)
Query: 99 LLSVIRQKEKDLVLAARLGKALLERNQDMSRQYE---QMHKELTDKLEHLEQEKHELRRR 155
L + + KE+ +VL +A +E ++RQ E QM K+ + L + E L+
Sbjct: 968 LKTTLAMKEEKIVLL----EAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNS 1023
Query: 156 FENREGE----------WEGRVSELESDVKQLQD---ELERQQIHLREADREKSRAVQEL 202
F++ G+ W E ++ +++D ELER L+ + +Q L
Sbjct: 1024 FKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHL 1083
Query: 203 SEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRK 262
QN Q+ L Q L+E + T + + +L ++ L+ +
Sbjct: 1084 ETQNVTFSSQILT-------LQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQY 1136
Query: 263 RELEHRLSATLEENDLLQGTVEE--------LQDRV---LILERQGHDKDLQLHQ----- 306
L++ +A EN+ LQ E+ LQD + ERQ + + + Q
Sbjct: 1137 TLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLK 1196
Query: 307 ---SQLELQEVRLSCR---------QLQVKVEELTEER-SLQSSAATSTSLLSEIEQSM- 352
LEL+ L R +L+ + + LT ER +LQ T+ + E ++
Sbjct: 1197 TLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRG 1256
Query: 353 EAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPA 412
E + + QL+ + E + + L + L N++ + DE E D+
Sbjct: 1257 ELDRVNFLHHQLKGEYEELHAHTKELKTSL--NNAQLELNRWQARFDELKEQHQTMDISL 1314
Query: 413 GSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIR 472
L L RL ++ E LLS ++ + L E+KE + QK
Sbjct: 1315 TKLDNHCELLSRLKGNL---EEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYI 1371
Query: 473 DRDEAIAK 480
D+ A+ +
Sbjct: 1372 DKLNALRR 1379
Score = 31.6 bits (70), Expect = 2.1
Identities = 14/44 (31%), Positives = 24/44 (54%)
Query: 112 LAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRR 155
L ++ + LLE+N + QY + K+ DKL L + K +L +
Sbjct: 1344 LLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 78.2 bits (191), Expect = 2e-14
Identities = 93/440 (21%), Positives = 198/440 (45%), Gaps = 28/440 (6%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + + ++ ++L A KA +E + + + K L L EK L ++ + +
Sbjct: 2163 LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
Query: 160 EGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEV 219
+G+ + +L S K L +E E+ +I ++E E AV+ L Q + L + ++
Sbjct: 2223 QGQLS-ELDKLLSSFKSLLEEKEQAEIQIKE---ESKTAVEMLQNQLKELNEAVAALCGD 2278
Query: 220 ERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKREL--EHRLSATLEEND 277
+ + +L E++ N +E L+A ++ +D K++L +L + D
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNS----IEKLRARLE--ADEKKQLCVLQQLKESEHHAD 2332
Query: 278 LLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRL-------SCRQLQVKVEEL-T 329
LL+G VE L+ + I L+ S+ E++ ++ S R L++ V + +
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 330 EERSLQSSAATSTSLLSEIE-QSMEAEELEQEREQLRLQLWE-AYCQVRYLCSHLRGNDS 387
E+ +L + +SE+E + E + QE+EQ ++Q+ E + + L + L+ +
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNE 2452
Query: 388 ADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTAL 447
+A+ D ++ E + + V L A +L+Q + + + L S +
Sbjct: 2453 RVAALHNDQEACKAKEQNLSSQVECLELEKA-----QLLQGLDEAKNNYIVLQSSVNGLI 2507
Query: 448 KEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQ 507
+E D + + E +L+ I+D+++ ++K + VE E + + L + ++ ++
Sbjct: 2508 QEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE-LE 2566
Query: 508 QKLNLSQQLEAWQDDMHRVI 527
QK+ + Q A D V+
Sbjct: 2567 QKIQVLQSKNASLQDTLEVL 2586
Score = 73.2 bits (178), Expect = 6e-13
Identities = 112/536 (20%), Positives = 228/536 (42%), Gaps = 85/536 (15%)
Query: 106 KEKDLV-LAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE 164
K+K +V L L ERNQ + + + M K+ T L+ L ++ E + E+ + E
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQ-LRGELDTMSKKTT-ALDQLSEKMKEKTQELESHQSECL 1999
Query: 165 GRVSELESDVKQLQD----------ELERQQIHLREADREKSRAVQELSEQNQRLLDQLS 214
+ E++VK+ + EL + + HL+E + + Q LS L +Q++
Sbjct: 2000 HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 215 RASE-----VERQLSMQVHALREDFREKNSST---------NQHIIRLESLQAEIKML-- 258
+ ++ V+ S+Q D+ + N S + +RL S Q E+ L
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 259 ----------SDRKRELE--HRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQ 306
+D K++L +L END L+ VE L+ + + E L
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAEN 2179
Query: 307 SQLELQEVRLSCRQL--QVKVEEL------TEERSLQSSAATSTSLLSEIEQSMEA-EEL 357
S+ E++ ++ ++ +KV EL +E+ +L LSE+++ + + + L
Sbjct: 2180 SKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
Query: 358 EQEREQLRLQLWE-AYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLR 416
+E+EQ +Q+ E + V L + L+ + A +A+ D + +++E S D P
Sbjct: 2240 LEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL--DPPIEEEH 2297
Query: 417 TALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDE 476
N +++L ++ ++ E + ++ + D L+ E+ E + ++ + ++
Sbjct: 2298 QLRNSIEKL-RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 477 AIAKKNAVELELAKCRMDMM--SLNSQLLDAI---QQKLNLSQQLEAWQDDMHRV----- 526
A+ + E+E K +++ M SL LD + +K NL+ +L+ Q+ + +
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
Query: 527 ---------------------IDRQLMDTHLKERSQPAAALCRGHSAGRGDEPSIA 561
+++ T LKE ++ AAL A + E +++
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLS 2472
Score = 67.0 bits (162), Expect = 4e-11
Identities = 105/458 (22%), Positives = 194/458 (42%), Gaps = 59/458 (12%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSR---QYEQMHKELT---DKLEHLEQEKHELRRRFEN 158
Q EK V K L + ++ R QY+Q + T KL+ L ++ R+ E+
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
Query: 159 REGEWEGRVSELESDVKQLQDELERQQIHLREADRE----KSRAVQELSEQNQR---LLD 211
E ++ E E K+ Q+EL RQQ + D+E K+R QEL + L
Sbjct: 381 ARCSLEQKIKEKE---KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 212 QLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSA 271
+L + + V++QL + E+F++K Q + QA ++ EL +
Sbjct: 438 ELDKLTSVKQQLENNL----EEFKQKLCRAEQ------AFQAS----QIKENELRRSMEE 483
Query: 272 TLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEE 331
+EN+LL+ E+ V LE + + L+QSQ +E++ + + +L E+
Sbjct: 484 MKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK 543
Query: 332 RSLQSSAATSTSL---LSEIEQSMEA-----EELEQEREQLRLQLWEAYCQVRYLCSHLR 383
+ Q ++ T L ++++E+ + ++ E EQL +L + + + L S L
Sbjct: 544 INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 384 GNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVE 443
+ + ++ ++ + K L T + K +QS ++ +E T L +
Sbjct: 604 LKKKEYEELKEEKTLFSCWKSENEK------LLTQMESEKENLQSKINHLE---TCLKTQ 654
Query: 444 MTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLL 503
E +R+R D +E L IR+ + K +VE+E K + ++
Sbjct: 655 QIKSHEYNERVRTLEMD---RENLSVEIRNLHNVLDSK-SVEVETQKLAYMELQQKAEFS 710
Query: 504 DAIQQK------LNLSQQLEAWQDDMHR--VIDRQLMD 533
D QK L SQ +D H+ ++ ++MD
Sbjct: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Score = 62.0 bits (149), Expect = 1e-09
Identities = 72/360 (20%), Positives = 149/360 (41%), Gaps = 40/360 (11%)
Query: 102 VIRQKEKDLVLAARLGKALLER-NQDMSRQYEQMH--KELTDKLEHLEQEKH---ELRRR 155
V++ L+ GK LE+ ++++SR Q+ ++L KL +E E E
Sbjct: 2498 VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE 2557
Query: 156 FENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSR 215
N E E ++ L+S LQD LE Q + + E + +++ ++
Sbjct: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 216 ASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKREL---------- 265
+E++R++ E E + N+ L+ L EIK D+ +EL
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 266 -----------EHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEV 314
E ++ + E L E+ +L+ + ++ ++Q ++ +L +E
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
Query: 315 RLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS-------MEAEELEQEREQLRLQ 367
LS ++L++ + + ++E L +S +T +L E++++ + + E ER Q +++
Sbjct: 2738 CLSSQKLEIDLLKSSKE-ELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ 427
L C+ + +S + E +T + D L T + ELK ++
Sbjct: 2797 LLIKSCK-----QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/486 (19%), Positives = 206/486 (42%), Gaps = 85/486 (17%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
+ ++ + +L++KLE+ + EL +R E EG L SD++ D+ R+ I
Sbjct: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEG--------LNSDLEMHADKSSREDIGDN 1885
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVERQL----SMQVHALREDFREKNSSTNQHI 245
A S + L +N+ + +AS L ++V + EK++ Q +
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Query: 246 IRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLH 305
I L+ E+ +++ + +L L ++ L E+++++ LE H + LH
Sbjct: 1946 I--VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELE--SHQSEC-LH 2000
Query: 306 QSQLELQEVRLSCRQLQVKVEELTE---------------ERSLQSSAATSTSLLSEIEQ 350
Q+ EV+ LQ +++E E+ Q+ + T L ++I Q
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQ 2060
Query: 351 -SMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKD 409
+ E E L +E E L+ +L E+ + + + + ++++ E E +
Sbjct: 2061 LNKEKELLVKESESLQARLSES------------DYEKLNVSKALEAALVEKGEFA---- 2104
Query: 410 VPAGSLRTALNELKRLIQSI---VDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQ 466
+ S + +++L+R I+ + ++ E ++ ++ + E D L+ E+ E + Q
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2164
Query: 467 LQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQL--LDAI---QQKLNLSQQLEAWQD 521
+ + ++ A+ + E+E K +++ M+ + ++ LD + +K NL++Q++ Q
Sbjct: 2165 MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG 2224
Query: 522 DMHRVIDR---------------------------QLMDTHLKERSQPAAALCRGHSAGR 554
+ +D+ +++ LKE ++ AALC +
Sbjct: 2225 QLSE-LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 555 GDEPSI 560
E S+
Sbjct: 2284 ATEQSL 2289
Score = 57.0 bits (136), Expect = 5e-08
Identities = 85/395 (21%), Positives = 163/395 (41%), Gaps = 54/395 (13%)
Query: 138 LTDKLEHLEQEKHELRRRFENREGEWE---GRVSELESDVKQLQDELERQQIHLREADRE 194
L ++E+LE+E R E+ E E G V L++ ++ + L ++ + E
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 195 KSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAE 254
K EL ++ +R+ SE+E S + L+E +EK + +E LQ +
Sbjct: 2394 KENLTNELQKEQERI-------SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 255 IKMLSDRKRELEHRLSATLEENDLLQGTVE--ELQDRVLILERQGHDKDLQLHQSQLE-- 310
+K L++R L + A + L VE EL+ L+ + + QS +
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Query: 311 LQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLW- 369
+QEV ++L+ K EE++ L++ L+S++ Q +E E QLW
Sbjct: 2507 IQEVEDGKQKLEKKDEEISR---LKNQIQDQEQLVSKLSQ-VEGEH----------QLWK 2552
Query: 370 EAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSI 429
E ++R L L ++ + +K+ +L + ++QS
Sbjct: 2553 EQNLELRNLTVEL----------------EQKIQVLQSKN-------ASLQDTLEVLQSS 2589
Query: 430 VDGMEPTVTLLSVEMTALKEERDRL--RVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELE 487
+E + L ++ + E+ +++ + T +E E QK ++E +KN + E
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 488 LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDD 522
L ++ S QL + + L + L+ D
Sbjct: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Score = 56.6 bits (135), Expect = 6e-08
Identities = 100/451 (22%), Positives = 189/451 (41%), Gaps = 48/451 (10%)
Query: 98 ELLSVIRQKEKDLVLAA-RLGKALLER----NQDMSRQYEQMHKELTDKLEHLEQEKHEL 152
+L I Q+E L L +L A LE+ +QD+ ++ E ++L DKL E+E L
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 153 RRRFENREGEWEGRV----------SELESDVKQLQDELERQQIHLREADREKSRAVQEL 202
E ++ E+E SE E + Q++ E E Q + + +
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
Query: 203 SEQNQRLLDQLSRASEVERQ-LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
E N+R+ R E++R+ LS+++ L K+ + LQ + + SD+
Sbjct: 659 HEYNERV-----RTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF-SDQ 712
Query: 262 K--RELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVR--LS 317
K +E+E+ T + L G VE+L+ ++ +L + DKD E + +R L
Sbjct: 713 KHQKEIENMCLKTSQ----LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 318 CRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRY 377
+ + E +RSL + S E + ER + RL+ ++
Sbjct: 769 SKDASLVTNE-DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 378 LCSHLRGNDSADSAVSTDSSMDESSETSSAKDVP-AGSLRTALNELKRLIQSIVDGMEPT 436
L + + DS + ++ + M+ + + V G + L + +++ QS V
Sbjct: 828 LQNRV---DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 437 VTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMM 496
++ L + +A + E+KE + QL + D+ VE E A+ + ++
Sbjct: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQL---LNDK---------VETEQAEIQ-ELK 931
Query: 497 SLNSQLLDAIQQKLNLSQQLEAWQDDMHRVI 527
N L D++++ LS+ L + +M +I
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSII 962
Score = 53.5 bits (127), Expect = 5e-07
Identities = 69/350 (19%), Positives = 152/350 (43%), Gaps = 38/350 (10%)
Query: 170 LESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHA 229
L++ V L+ LE Q+ + ++ VQ E + L+ + S ++
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
Query: 230 LREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQ-- 287
L+ED + + + LE+ + E+++L+D+ + + + N LL+ +++ELQ
Sbjct: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSL--QSSAATSTSLL 345
L LE++ + L++ + +EELT+E + +A+ + +
Sbjct: 948 SETLSLEKKEMSSIISLNKRE----------------IEELTQENGTLKEINASLNQEKM 991
Query: 346 SEIEQSMEAEELEQEREQLRLQLWEAYCQVRYL----CSHLRGNDSADSAVSTDSSMDES 401
+ I++S ERE+ +L + Y Q + + C GN D + ++ +++
Sbjct: 992 NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEE-TGNAYEDLSQKYKAAQEKN 1050
Query: 402 SETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDK 461
S+ + NEL++L ++ + +T L A EER++ +
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL-----AFAEERNQNLMLE--- 1102
Query: 462 EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLN 511
E +Q+A+ R E +N + E + ++M+L + + +Q+++N
Sbjct: 1103 --LETVQQAL--RSEMTDNQNNSKSEAGGLKQEIMTLKEE-QNKMQKEVN 1147
Score = 53.1 bits (126), Expect = 7e-07
Identities = 78/408 (19%), Positives = 172/408 (42%), Gaps = 31/408 (7%)
Query: 145 LEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLRE----ADREKSRAVQ 200
LE+ K L R + E EG++ +L+ + +Q Q +L+ + L++ + EK+
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 201 ELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKML-S 259
L +NQRL++ + ++++S ++ + N ++E L+ E+K S
Sbjct: 65 -LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 260 DRKRELEHRLSATLEENDLLQGTVEELQDRVLILE-----------RQGHDKDLQLHQSQ 308
+ +R + SA + N T +++ L ++ ++K+++ + +
Sbjct: 124 ELERSQQAAQSADVSLNPC--NTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE-ERKR 180
Query: 309 LELQEVRLSCRQLQVKVEELT-EERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQ 367
LE + L ++ + + T R + A+S+ + E++ +R +R
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGS--LRTALNELKRL 425
+Y + R + S D SS + A + LR +NEL+
Sbjct: 241 FSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR 300
Query: 426 IQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDK---EPKEQLQKAIRDRDEAIAKKN 482
+Q M+ V + L+ E+ ++ + ++K + +++L + D+A K
Sbjct: 301 LQGHEKEMKGQVN--KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 483 AVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQ 530
A+E +L K D L+ Q +A + +L Q+++ + + + RQ
Sbjct: 359 ALEQKLKKLTED---LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQ 403
Score = 50.8 bits (120), Expect = 3e-06
Identities = 79/448 (17%), Positives = 181/448 (40%), Gaps = 43/448 (9%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHEL----- 152
+L + + + ++ L A + +A + ++ R E+M KE H EQ+ E+
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 153 --------RRRFENREGEWEGRVSELESDVKQLQDELERQQ-------IHLREADREKSR 197
+ +N E + + + E+ ++ LQ+++ +Q+ + L AD EK R
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 198 -AVQELSEQNQRLLDQLS-RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEI 255
Q+L ++ + ++QL+ + S+ E++ + AL +E E L+ E
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE-----------YEELKEEK 616
Query: 256 KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVR 315
+ S K E E L+ E + LQ + L+ + + + H+ + ++ +++ + +
Sbjct: 617 TLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS 676
Query: 316 LSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQ---EREQLRLQLWEAY 372
+ R L ++ + E Q A +E +E+E + QL Q+ +
Sbjct: 677 VEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
Query: 373 CQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDG 432
+++ L + + D D + S K A + ++ L
Sbjct: 737 HKLQLLSNEIMDKDRC----YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 792
Query: 433 MEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQ--LQKAIRDRDEAIAKKNAVELELAK 490
M + + E ++ ER R+ + D+ PK LQ + + ++ + + +L K
Sbjct: 793 MHHSFANIIGEQGSMPSERSECRLEA-DQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK 851
Query: 491 CRMDMMSLNSQLLDAIQQKLNLSQQLEA 518
+++ + ++ + + + + Q A
Sbjct: 852 QCEELVQIKGEIEENLMKAEQMHQSFVA 879
Score = 48.5 bits (114), Expect = 2e-05
Identities = 73/368 (19%), Positives = 152/368 (41%), Gaps = 65/368 (17%)
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
Q+++ Q+ ++E E R + + ++++++ L+ E++ +L +Q L
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKI--- 1822
Query: 238 NSSTNQHIIRLESLQAEIKML-SDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQ 296
+ I LE + E+K SD +LE+ + + +LLQ + +
Sbjct: 1823 -----EACIELEKIVGELKKENSDLSEKLEY---FSCDHQELLQR----------VETSE 1864
Query: 297 GHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEE 356
G + DL++H + +++ + KV + +ER L S + +E+
Sbjct: 1865 GLNSDLEMHADKSSREDIGDNV----AKVNDSWKERFLDVENELSR---------IRSEK 1911
Query: 357 LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL- 415
E E L L+ Q LC + V + +E S +S ++ G L
Sbjct: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE---EELSVVTSERNQLRGELD 1968
Query: 416 -----RTALNEL----KRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQ 466
TAL++L K Q + + + V +KE+ + L+ S D +
Sbjct: 1969 TMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLK 2028
Query: 467 LQKAIRDRDEAIAKKNAVELELAKCRMDMM----------------SLNSQLLDAIQQKL 510
+ ++++ +++ +K++ L L KC ++ SL ++L ++ +KL
Sbjct: 2029 DKTHLQEKLQSL-EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
Query: 511 NLSQQLEA 518
N+S+ LEA
Sbjct: 2088 NVSKALEA 2095
Score = 45.1 bits (105), Expect = 2e-04
Identities = 113/539 (20%), Positives = 208/539 (38%), Gaps = 87/539 (16%)
Query: 57 EEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARL 116
E+EL LL +D E QAE L + ++ +LLS EK +
Sbjct: 910 EKELQLL------NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM----- 958
Query: 117 GKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRR---FENREGEWEGRVSELESD 173
+++ N+ + Q + L + L QEK L ++ F N E E +SEL
Sbjct: 959 -SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Query: 174 VKQ-------------------------LQDELERQQIHLREA-------DREKSRAVQE 201
KQ Q++ + + L E E + +
Sbjct: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
Query: 202 LSEQNQRLLDQLSRASEVERQLSMQVHALREDFR-EKNSSTNQHIIRLESLQAEIKMLSD 260
++++Q L +L+ A E + L +++ +++ R E + N L+ EI L +
Sbjct: 1078 FAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE 1137
Query: 261 RKRELEHRLSATLEENDLL---QGTVEELQD------RVLILERQGHDKDLQLH-QSQLE 310
+ +++ ++ L+EN+ L T E Q+ R + ER+ Q LE
Sbjct: 1138 EQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLE 1197
Query: 311 LQEVRLSCRQLQ-VKVEEL--TEERSLQSSAATSTSL---LSEIEQSMEAEELE--QERE 362
++E+ L Q V++E + +E LQ S L L I +E L+ Q +E
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Query: 363 QLRLQLWEAYCQVRYLCS----HLRGNDSADSAVSTDSSMDESSETSSAKDVPAG---SL 415
L+ E + +Y+ ND+A S ++M++ +E ++ L
Sbjct: 1258 ISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYEL 1317
Query: 416 RTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLR-VTSED-------KEPKEQL 467
T LN+ + + M V L E+ L ++ L ED ++P EQ
Sbjct: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377
Query: 468 QKAIRDRDEAIAKKN------AVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQ 520
++ DE+ + ++ V++ A+ + +SL S+ Q +S ++ Q
Sbjct: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
Score = 41.6 bits (96), Expect = 0.002
Identities = 58/278 (20%), Positives = 113/278 (40%), Gaps = 36/278 (12%)
Query: 265 LEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVK 324
L+ R+ T EN L +E+ +V L + + D +LH +++L +C +L+
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1831
Query: 325 VEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRG 384
V EL +E S++ + +E + + R++ E
Sbjct: 1832 VGELKKEN-------------SDLSEKLEYFSCDHQELLQRVETSEGL------------ 1866
Query: 385 NDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEM 444
N + S D + D NEL R I+S +E L ++
Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR-IRSEKASIEHEALYLEADL 1925
Query: 445 TALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLD 504
++ E+ L +E+K QK I +E ++ + +L + +D MS + LD
Sbjct: 1926 EVVQTEKLCLEKDNENK------QKVIVCLEEELSVVTSERNQL-RGELDTMSKKTTALD 1978
Query: 505 AIQQKL-NLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
+ +K+ +Q+LE+ Q + I Q+ + +KE+++
Sbjct: 1979 QLSEKMKEKTQELESHQSECLHCI--QVAEAEVKEKTE 2014
Score = 37.7 bits (86), Expect = 0.029
Identities = 72/372 (19%), Positives = 144/372 (38%), Gaps = 31/372 (8%)
Query: 164 EGRVSELESDVKQLQ-DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQ 222
EG VS + V ++ L+ + + +E ++ V+EL EV RQ
Sbjct: 1513 EGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELES-----------LCEVYRQ 1561
Query: 223 LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEEND----L 278
+ L E + N+ I LE L LS ++EL+ L EN+
Sbjct: 1562 ---SLEKLEEKMESQGIMKNKEIQELEQL------LSSERQELDCLRKQYLSENEQWQQK 1612
Query: 279 LQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQ-LQVKVEELTEERSLQSS 337
L E++ ++ ++Q L+L ++L+LQ + LS R L + E+ + R+ S
Sbjct: 1613 LTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRN--ES 1670
Query: 338 AATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSS 397
S SE + ++ Q ++ Q + ++ S D++
Sbjct: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
Query: 398 MDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVT 457
+ E + S + + L+ G + + L + + E RL
Sbjct: 1731 YEPPGEDKTQGSSECIS-ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
Query: 458 SEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
ED++ K ++ + + E +K + E++L + L + + ++ +LS++LE
Sbjct: 1790 IEDRDRK--VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847
Query: 518 AWQDDMHRVIDR 529
+ D ++ R
Sbjct: 1848 YFSCDHQELLQR 1859
Score = 36.6 bits (83), Expect = 0.064
Identities = 39/183 (21%), Positives = 79/183 (43%), Gaps = 18/183 (9%)
Query: 120 LLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQD 179
LL+ N+ + + ++LT K E L +K E+ ++E EL + +K
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE--------ELNNSLKATTQ 2765
Query: 180 ELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF----- 234
LE L++ + + V +L ++N+R ++ + +QL + L+++
Sbjct: 2766 ILEE----LKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA 2821
Query: 235 -REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLIL 293
+EK + +++ L EIK L + E L++ L + E+L+ +L
Sbjct: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEML 2881
Query: 294 ERQ 296
E Q
Sbjct: 2882 ETQ 2884
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 77.4 bits (189), Expect = 3e-14
Identities = 96/443 (21%), Positives = 181/443 (40%), Gaps = 52/443 (11%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
+ V+ Q + D + +A L+ Q + E++ EL DK+ L+ E +
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLL--- 1289
Query: 160 EGEWEGRVSELESDVKQLQDELERQQIHLREADREK---SRAVQELSEQNQRLLDQLSRA 216
+ + + S+L D L+ +L+ Q L+E +R+K S ++++ ++ +QL
Sbjct: 1290 -SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Query: 217 SEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEEN 276
E + L Q+ L + + LE+ + + L L R +
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408
Query: 277 DLLQGT----VEELQDRVLILERQGHD----KDLQLHQSQLELQEVRLSCRQLQVKVEEL 328
D L+ T +EL D ++ L+ Q + Q QL +E +S + + +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 329 TEERSLQSSAATSTSLLSEIEQSMEAE-ELEQEREQLRLQLWEAYCQVRYLCSHLRGNDS 387
E R ++ A SL +E++ME + ELE+ +Q R ++ D
Sbjct: 1469 AEAREKETKA---LSLARALEEAMEQKAELERLNKQFRTEM----------------EDL 1509
Query: 388 ADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTAL 447
S S+ E ++ A + ++T L EL+ +Q+ D L V + A+
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK----LRLEVNLQAM 1565
Query: 448 KE--ERDRLRVTSEDKEPKEQLQKAIRD-----------RDEAIAKKNAVELELAKCRMD 494
K ERD + +E K+QL + +R+ R A+A + +E++L
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 495 MMSLNSQLLDAIQQKLNLSQQLE 517
+ S N +AI+Q L Q++
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMK 1648
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/435 (20%), Positives = 195/435 (44%), Gaps = 41/435 (9%)
Query: 127 MSRQYEQMHKELTDKLEHLEQEKHEL---RRRFENREGEWEGRVSELESDVKQLQDELER 183
+ ++E M +L ++L E+++ EL RR+ E + +++EL++ + +L+ +L +
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 184 QQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQ 243
++ L+ A +R +E +++N L + E+E Q+S L+ED + +S N+
Sbjct: 1081 KEEELQAA---LARVEEEAAQKNMAL----KKIRELESQIS----ELQEDLESERASRNK 1129
Query: 244 HIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQ 303
+ L E++ L K ELE L +T + +L +E+ LE + + Q
Sbjct: 1130 AEKQKRDLGEELEAL---KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 304 LHQ-SQLELQEVRLSCRQL-QVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE-ELEQE 360
+ + Q Q V QL Q K + E++ Q+ L +E++ ++ + + E +
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 361 REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALN 420
R+++ QL E QV++ + AD +D + S D + L +
Sbjct: 1247 RKKVEAQLQE--LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 421 ELKRLIQSIVDGMEP---TVTLLSVEMTALKEERDRLR-VTSEDKEPKEQLQKAI----- 471
L+ +Q + ++ LS ++ +++E++ R E++E K L+K I
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 472 ------RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHR 525
+ ++++ E K + D+ L+ + ++K+ +LE + + +
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR----HEEKVAAYDKLEKTKTRLQQ 1420
Query: 526 VIDRQLMDTHLKERS 540
+D L+D + +S
Sbjct: 1421 ELDDLLVDLDHQRQS 1435
Score = 73.9 bits (180), Expect = 4e-13
Identities = 104/489 (21%), Positives = 207/489 (42%), Gaps = 63/489 (12%)
Query: 104 RQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKL---EHLEQEKHEL---RRRFE 157
R+KE + AR + +E+ ++ R +Q E+ D + + + + HEL +R E
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLR---------------EADREKSRAVQEL 202
+ E + ++ ELE +++ +D R +++L+ +++ +K + V+++
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 203 SEQNQRLLD---QLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLS 259
E L D Q S A ++L M + L N + ++ I +L LQA++K
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK--- 1648
Query: 260 DRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCR 319
D REL D + + EE+ + E++ + ++ Q Q EL + R
Sbjct: 1649 DCMREL-----------DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 320 QLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLC 379
Q Q + +EL +E + +S+ L E LE QL +L E +
Sbjct: 1698 QAQQERDELADE--IANSSGKGALALE------EKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 380 SHLRGNDSADSAVSTDSSMDES--SETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTV 437
L+ + ++TD +++ S + +A+ + +L+ + ++ + ++
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 438 TLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMS 497
T L ++ L+E+ D E KE+ Q A + K V L++ R +
Sbjct: 1810 TALEAKIAQLEEQL--------DNETKER-QAACKQVRRTEKKLKDVLLQVDDERRNAEQ 1860
Query: 498 LNSQLLDAIQQKLNLSQQLEAWQDDMHRV-IDRQLMDTHLKERSQPAAALCRGHSA---- 552
Q A + L +QLE +++ R R+ + L++ ++ A A+ R S+
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Query: 553 -GRGDEPSI 560
RGD P +
Sbjct: 1921 LRRGDLPFV 1929
Score = 72.0 bits (175), Expect = 1e-12
Identities = 94/454 (20%), Positives = 186/454 (40%), Gaps = 57/454 (12%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSE---LESDVKQL 177
L+ ++ + E++ LT K + LE+ H+L R E E + +E ++ ++++L
Sbjct: 889 LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 178 QDELERQQIHLREADREK---SRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234
+++LE ++ ++ EK +++L E+ L DQ + ++ ++ L ++ +
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 235 REKNSST-------NQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQ 287
E+ + N+H + L+ ++ +++ELE ++ L + ELQ
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 288 DRVLILERQGHDKDLQLH-----------QSQLELQEVRLSCRQLQVKVEELTEERSLQS 336
++ L+ Q K+ +L Q + L+++R Q+ E+L ER+ ++
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN 1128
Query: 337 SA------------ATSTSLLSEIEQSMEAEELEQEREQ----LRLQLWEAYCQVRYLCS 380
A A T L ++ + +EL +REQ L+ L E
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 381 HLRGNDS---ADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDG--MEP 435
+R S + A + + + AK NE+K L+Q D
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 436 TVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDM 495
V E+ E +R+R DK K Q+ + D + + + +K D
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQV-----ELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 496 MSLNSQLLDAIQ-------QKLNLSQQLEAWQDD 522
+L SQL D + QKL+LS +L+ +D+
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 67.8 bits (164), Expect = 3e-11
Identities = 98/432 (22%), Positives = 188/432 (43%), Gaps = 44/432 (10%)
Query: 125 QDMSRQYEQMHKELTD-KLEHLEQEKHEL----------RRRFENREGEWEGRVSELESD 173
++ +RQ Q+ K T+ KL+ LE+E+ L ++ E+R E+ ++E E
Sbjct: 955 EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 174 VK---QLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHAL 230
K +L+++ E L E R + + QEL + ++L + S+ +L Q+ L
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074
Query: 231 REDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE--ENDLLQGTVEELQD 288
+ +K + R+E A+ M + RELE ++S E E++ E Q
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134
Query: 289 RVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI 348
R L E + +L+ Q+ S R+ +V + + T E ++ A + +
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 349 EQSME--AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSS 406
Q++E AE+LEQ + +++ L +A + + RG + + V D S
Sbjct: 1195 SQAVEELAEQLEQTK-RVKANLEKA----KQTLENERGELANEVKVLLQGKGD-SEHKRK 1248
Query: 407 AKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEM---TALKEERDRLRVTSEDKEP 463
+ L+ NE +R+ + D VT L VE+ T L + D +S+ +
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELAD----KVTKLQVELDNVTGLLSQSD--SKSSKLTKD 1302
Query: 464 KEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
L+ ++D E + ++N +L SL+++L +K + +QLE ++
Sbjct: 1303 FSALESQLQDTQELLQEENRQKL----------SLSTKLKQVEDEKNSFREQLEEEEEAK 1352
Query: 524 HRVIDRQLMDTH 535
H +++Q+ H
Sbjct: 1353 HN-LEKQIATLH 1363
Score = 65.5 bits (158), Expect = 1e-10
Identities = 87/432 (20%), Positives = 179/432 (41%), Gaps = 34/432 (7%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
Q + +E+ K E L + + E + ENR E E S+L ++ QLQ++L+ +
Sbjct: 839 QVSRQEEEMMAKEEELVKVR-EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ ++R + E + D +R E E +++ + L E E+ S
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A++K L + + LE + +E LL+ + E + E +
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN--LTEEEEKS 1015
Query: 300 KDL----QLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI-----EQ 350
K L H++ + E RL + Q + E T R L+ + + ++E+ E
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKT-RRKLEGDSTDLSDQIAELQAQIAEL 1074
Query: 351 SMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDV 410
M+ + E+E + ++ E Q +R +S S + D + +S + K
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ- 1133
Query: 411 PAGSLRTALNELKRLIQSIVDGMEPTVTLLS---VEMTALKEERDRLRVTSED--KEPKE 465
L L LK ++ +D L S E+ LK+ + T E +E ++
Sbjct: 1134 -KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 466 QLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHR 525
+ +A+ + E + + V+ L K + + + +L + ++ L Q + + +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL----QGKGDSEHKRK 1248
Query: 526 VIDRQLMDTHLK 537
++ QL + +K
Sbjct: 1249 KVEAQLQELQVK 1260
Score = 60.5 bits (145), Expect = 4e-09
Identities = 79/354 (22%), Positives = 159/354 (44%), Gaps = 36/354 (10%)
Query: 208 RLLDQLSRASEVERQLSMQVHALREDF---REKNSSTNQHIIRLESLQAEIKMLSDRKRE 264
RL ++ +V RQ ++ A E+ REK + + +E+LQ++ L K +
Sbjct: 829 RLFTKVKPLLQVSRQ-EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQ---LMAEKLQ 884
Query: 265 LEHRLSATLEENDLLQGTVEELQDRVLI----LERQGHDKDLQLHQSQLELQEVRLSCRQ 320
L+ +L A E L EEL+ R+ LE HD + ++ + + Q ++ ++
Sbjct: 885 LQEQLQAETE----LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKK 940
Query: 321 LQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCS 380
+Q ++EL E+ + SA L + + EA+ + E EQ+ L+ + C+ L
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLE---KVTTEAKLKKLEEEQIILE--DQNCK---LAK 992
Query: 381 HLRGNDSADSAVSTDSSMDESSETSSAK-DVPAGSLRTALNELKRLIQSIVDGMEPTVTL 439
+ + + +T+ + +E S AK ++ T L E R + +E T
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 440 LSVEMTALKEERDRLRVTSED-----KEPKEQLQKAIRDRDEAIAKKNA-------VELE 487
L + T L ++ L+ + + +E+LQ A+ +E A+KN +E +
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Query: 488 LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQ 541
+++ + D+ S + A +QK +L ++LEA + ++ +D L+ + +
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Score = 58.5 bits (140), Expect = 2e-08
Identities = 96/456 (21%), Positives = 185/456 (40%), Gaps = 52/456 (11%)
Query: 122 ERNQDMSRQYEQMHKELTDK----------LEHLEQEKHELRRRFENREGEWEGRVS--- 168
E ++ +Q +H ++ D LE E+ K +L++ E E +V+
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409
Query: 169 ELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQL-SRASEVERQLSMQV 227
+LE +LQ EL+ + L D ++ A E+ Q+ DQL + + + + +
Sbjct: 1410 KLEKTKTRLQQELDDLLVDL---DHQRQSACN--LEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 228 HALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQ 287
+ REK + LE + L ++ + + D + +V EL+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE--ERSLQ----SSAATS 341
LE+Q + QL + + ELQ + +L+V ++ + ER LQ S
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584
Query: 342 TSLLSEIEQSMEAEELEQEREQLRLQL---WEAYCQVRYLCSHL-RGNDSADSAV----- 392
L+ ++ + MEA ELE ER+Q + + + ++ L +H+ N + D A+
Sbjct: 1585 KQLVRQVRE-MEA-ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Query: 393 ---STDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKE 449
M E +T ++++ + +LK + ++ E + A ++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA-QQ 1701
Query: 450 ERDRLR---VTSEDK-----EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQ 501
ERD L S K E K +L+ I +E + ++ EL R+ +L
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG-NTELINDRLKKANLQ-- 1758
Query: 502 LLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLK 537
+D I LNL + ++ + ++RQ + +K
Sbjct: 1759 -IDQINTDLNLERSHAQKNENARQQLERQNKELKVK 1793
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 76.6 bits (187), Expect = 6e-14
Identities = 104/491 (21%), Positives = 209/491 (42%), Gaps = 67/491 (13%)
Query: 95 QDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQY----EQMHKELTDKLEHLEQEKH 150
Q E L ++EK L + K LE + ++++ Q ++L +KL+ + E
Sbjct: 1078 QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELS 1137
Query: 151 ELRRRFENRE---GEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQ 207
+L R E+ + + + ++ EL++ ++L++ELE ++ +++++ A +EL E ++
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 208 RLLDQLSRASEVERQ----LSMQVHALREDFREKNSSTNQHIIRLESLQAE--------I 255
R L++ AS +R+ ++ LR + E + L QAE +
Sbjct: 1198 R-LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV 1256
Query: 256 KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVR 315
L +++LE S E D L VE L E+ + QL +++++++E++
Sbjct: 1257 DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Query: 316 LSCRQLQVKVEELTEERSLQSSAATSTSLLSEIE---------QSMEAEELEQEREQLRL 366
RQL + T+ LQ+ + + LL E E +++ A+ LE+ R QL
Sbjct: 1317 ---RQL---ADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQL-- 1368
Query: 367 QLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLI 426
E + + +H A A+ D + A+ A EL+RL+
Sbjct: 1369 ---EEESKAKSALAH------AVQALRHDCDLLREQHEEEAE---------AQAELQRLL 1410
Query: 427 QSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVEL 486
V K E D ++ T E +E K++L +++ +E + NA
Sbjct: 1411 SK---------ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCS 1461
Query: 487 ELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAAL 546
L K ++ + + + + +++ + + L+ Q + R ++ + +R AA
Sbjct: 1462 SLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA-- 1519
Query: 547 CRGHSAGRGDE 557
+ S G G E
Sbjct: 1520 -QRESRGLGTE 1529
Score = 60.5 bits (145), Expect = 4e-09
Identities = 103/465 (22%), Positives = 193/465 (41%), Gaps = 66/465 (14%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
+Q+ L++ Q E+D + A LL +++ Q E KEL+++LE E+ +L
Sbjct: 930 TQEKNDLALQLQAEQDNLADAEERCHLLIKSKV---QLEGKVKELSERLEDEEEVNADL- 985
Query: 154 RRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREK---SRAVQELSEQNQRLL 210
R +LE + +L+ +++ ++ L +A++EK V+ L+E+ L
Sbjct: 986 ----------AARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALD 1035
Query: 211 DQLSRASEVERQLSMQVHALREDFR---EKNSSTNQHIIRLE--------SLQAEIKMLS 259
+ ++R ++ ++ L D + ++ S+ + +RLE SL+ E K+
Sbjct: 1036 ESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRM 1095
Query: 260 D---RKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRL 316
D KR+LE L T E ++L++++ + + L++ QL +++
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1155
Query: 317 SCRQLQVKVEELTEERSLQSSA--------ATSTSLLSEIEQSME------------AEE 356
++LQ + EEL EE + +A A + L E+ + +E +
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 357 LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLR 416
E E +LR +L EA + + LR A+ A +D + LR
Sbjct: 1216 REAELGRLRRELEEAALRHEATVAALR-RKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 417 TALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDE 476
+++L ++ TL + +A K R SE K E+LQ+ + D
Sbjct: 1275 MEVDDLAANVE----------TLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAST 1324
Query: 477 AIAKKNAVELELAKCRMDMMSLNSQLLD----AIQQKLNLSQQLE 517
+ EL++ + L SQL A Q L +QLE
Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE 1369
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/164 (26%), Positives = 76/164 (46%), Gaps = 14/164 (8%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGE-- 162
+K K + A + L++ QD S E+M K LEQ EL+ R E E
Sbjct: 1802 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKT-------LEQTVRELQARLEEAEQAAL 1854
Query: 163 --WEGRVSELESDVKQLQDELERQQIHLREA---DREKSRAVQELSEQNQRLLDQLSRAS 217
+ +V +LE+ V++L+ EL+ +Q EA R+ R V+EL+ Q + L+R
Sbjct: 1855 RGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQ 1914
Query: 218 EVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
++ +L +V + + F E N ++ + Q E+ +R
Sbjct: 1915 DLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEER 1958
Score = 53.1 bits (126), Expect = 7e-07
Identities = 100/448 (22%), Positives = 182/448 (40%), Gaps = 68/448 (15%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQ-------EKHELRRRFENREGEW---EGRV 167
K L + + + E K LT+++ L++ EK L+ + G+ E RV
Sbjct: 1007 KLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRV 1066
Query: 168 SELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLD-QLSRASEVERQLSMQ 226
S L +L+ QQ+ E E+ + ++ +E+ +R L+ L E +
Sbjct: 1067 SALTKAKLRLE-----QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQD 1121
Query: 227 VHALREDFREKNSSTNQHIIRLE-------SLQAEIKMLSDRKRELEHRLSATLEENDLL 279
L E ++K+S +Q +R+E +Q +IK L R ELE L A +
Sbjct: 1122 KQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARV 1181
Query: 280 Q-------GTVEELQDRVLILERQGHDKDLQ---LHQSQLELQEVRLSCRQLQVKVEELT 329
+ +EEL +R LE G Q + + EL +R + ++ E
Sbjct: 1182 EKQRAEAARELEELSER---LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATV 1238
Query: 330 EERSLQSSAATSTSLLSEIEQSME--AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDS 387
+L+ A + L E S++ ++LE+E+ +LR+++ + V L R S
Sbjct: 1239 --AALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL---TRAKAS 1293
Query: 388 ADSAVST--------DSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTL 439
A+ T ++E + G L+T EL RL++ E ++
Sbjct: 1294 AEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE----KECLISQ 1349
Query: 440 LS----VEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELE-------- 487
LS + +L+E R +L S+ K +A+R + + +++ E E
Sbjct: 1350 LSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL 1409
Query: 488 LAKCRMDMMSLNSQL-LDAIQQKLNLSQ 514
L+K ++ S+ DAIQ+ L +
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEE 1437
Score = 52.8 bits (125), Expect = 9e-07
Identities = 108/515 (20%), Positives = 200/515 (38%), Gaps = 86/515 (16%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERN-QDMSRQYEQMHK------ELTDKLEH---LEQEK 149
LS + ++++ L+ GKAL ++ +++ RQ E+ K L H L +E+
Sbjct: 1336 LSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQ 1395
Query: 150 HE--------LRRRFENREGEWEGRVSELESDVKQLQDELERQQ----IHLREADR---- 193
HE L+R E S+ E+D Q +ELE + + L+EA+
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEA 1455
Query: 194 ------EKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIR 247
+A L +++ + +L RA+ L + L E+ +
Sbjct: 1456 ANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRE 1515
Query: 248 LESLQAEIKMLSDRKRELEHRLSATLE-------ENDLLQGTVEELQDRVLI-------L 293
LE+ Q E + L L H LE EN LQ + +L D+V + L
Sbjct: 1516 LEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQEL 1575
Query: 294 ER-----QGHDKDLQL----HQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSL 344
E+ +G ++Q + LEL+E + QL++ + +R L +L
Sbjct: 1576 EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANL 1635
Query: 345 LSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSET 404
++++E+ + + E A + L + G D D + + +++E
Sbjct: 1636 RRNHQRAVESLQASLDAET------RARNEALRLKKKMEG-DLNDLELQLGHATRQATEA 1688
Query: 405 SSAKDVPAGSLR---TALNELKRLIQSI---VDGMEPTVTLLSVEMTALKE-----ERDR 453
+A + L+ +E +RL + +E +LL+ E+ L+ ER R
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSR 1748
Query: 454 LRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLS 513
E E E+L + +K +E +LA+ L+ ++ +A Q++
Sbjct: 1749 RLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQ-------LSGEVEEAAQER---- 1797
Query: 514 QQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCR 548
EA + + D +M LK+ +A L R
Sbjct: 1798 --REAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1830
Score = 47.4 bits (111), Expect = 4e-05
Identities = 58/264 (21%), Positives = 116/264 (43%), Gaps = 19/264 (7%)
Query: 111 VLAARLG--KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVS 168
+LAA L +A LE+ + R EQ E T++L L + L + +
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKK----------- 1777
Query: 169 ELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVH 228
+LE+D+ QL E+E REA+ + +A+ + + + L + ++ +ER
Sbjct: 1778 KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQ 1837
Query: 229 ALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQD 288
+RE + + Q +R + +++ L + RELE L A +++ V + +
Sbjct: 1838 TVRE-LQARLEEAEQAALR--GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHER 1894
Query: 289 RVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI 348
RV L Q + L + Q + +++ + + + EE E+ ++ A E+
Sbjct: 1895 RVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEE--AEQQANTNLAKYRKAQHEL 1952
Query: 349 EQSME-AEELEQEREQLRLQLWEA 371
+ + E A+ E + +LR + +A
Sbjct: 1953 DDAEERADMAETQANKLRARTRDA 1976
Score = 43.5 bits (101), Expect = 5e-04
Identities = 78/344 (22%), Positives = 145/344 (42%), Gaps = 48/344 (13%)
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM 225
R ++ E ++ L+ EL + L A+ ++ QEL E + + + + L++
Sbjct: 890 RSAQAEEELAALRAELRGLRGALAAAEAKR----QELEETHVSITQE-------KNDLAL 938
Query: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEE 285
Q+ A +++ + H++ +Q E K+ +EL RL E N L +
Sbjct: 939 QLQAEQDNLADAEERC--HLLIKSKVQLEGKV-----KELSERLEDEEEVNADLAARRRK 991
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEE-RSLQSSAATST-- 342
L+D L++ D L L +++ E Q + KV+ LTEE +L S A T
Sbjct: 992 LEDECTELKKDIDDLKLTLAKAEKEKQAT-------ENKVKNLTEEMAALDESVARLTKE 1044
Query: 343 -SLLSEIEQ----SMEAEE-----LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAV 392
L E Q ++AEE L + + +L Q+ + C + + A +
Sbjct: 1045 KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 1104
Query: 393 STDSSMDESSETSSAKDVP--AGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEE 450
D + + S +A+D L+ +EL +L + D LL +M +++
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQ-----LLGAQM---QKK 1156
Query: 451 RDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMD 494
L+ +E+ E + + ++A R R E + A ELE R++
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 75.9 bits (185), Expect = 1e-13
Identities = 95/433 (21%), Positives = 192/433 (44%), Gaps = 64/433 (14%)
Query: 128 SRQYEQMHKE---LTDKLEHLEQEKHELRRRFENREGEWEG-------RVSELESDVKQL 177
S++ EQ+ +E L KL+ LE E EL+ EN E + E +++E+++ V+ L
Sbjct: 207 SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSL 266
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
E E+Q +LR EK +Q SEQN L+++L +A LS +V L+ + +
Sbjct: 267 --EAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVE-----------EL 286
+ I+LE+ +A+ ++ +R + ++ L +N++L+ VE EL
Sbjct: 323 ITD-----IKLETARAKSELERERNK-IQSELDGLQSDNEILKAAVEHHKVLLVEKDREL 376
Query: 287 QDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLS 346
+V + +G+ K + L +LEL+ +++V+ + + Q S ++
Sbjct: 377 IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMA 436
Query: 347 EIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSS 406
E E +E + +RL+L + + ++A + + + S
Sbjct: 437 E-------EITRKELQSVRLKLQQQIVTI-------------ENAEKEKNENSDLKQQIS 476
Query: 407 AKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRV----TSEDK- 461
+ + SL + N+L Q + + +E L E + + ++ ++ T E+K
Sbjct: 477 SLQIQVTSLAQSENDLLNSNQMLKEMVER----LKQECRNFRSQAEKAQLEAEKTLEEKQ 532
Query: 462 ----EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
E K +L + I DR+E + A + SL+ L +Q+K+ + + +
Sbjct: 533 IQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK 592
Query: 518 AWQDDMHRVIDRQ 530
+ ++V++RQ
Sbjct: 593 EELETENQVLNRQ 605
Score = 52.4 bits (124), Expect = 1e-06
Identities = 82/374 (21%), Positives = 150/374 (40%), Gaps = 48/374 (12%)
Query: 107 EKDLVLAARLGKALLERNQDMSRQYEQMHK---ELTDKLEHLEQEKHELRRRFENREGEW 163
E++ L +L KA E N S+ E H E+TD + K EL R + E
Sbjct: 289 EQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSEL 348
Query: 164 EGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQN-QRLLDQLSRASEVERQ 222
+G L+SD + L+ +E ++ L E DRE R VQ E+ Q+L+ E+E +
Sbjct: 349 DG----LQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENR 404
Query: 223 LS--MQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ 280
L+ ++ + +R+ + +R + EI RK LQ
Sbjct: 405 LADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI----TRKE---------------LQ 445
Query: 281 GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE-ERSLQSSAA 339
+LQ +++ +E +K+ E +++ LQ++V L + E L +S
Sbjct: 446 SVRLKLQQQIVTIENAEKEKN--------ENSDLKQQISSLQIQVTSLAQSENDLLNSNQ 497
Query: 340 TSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMD 399
++ ++Q + E+ QL + Q+++L + ++ +
Sbjct: 498 MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAK 557
Query: 400 ESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSE 459
E + ++ SL N+LKRL + V +L + L+ E L +
Sbjct: 558 EKLQRAAIAQKKRKSLHE--NKLKRL--------QEKVEVLEAKKEELETENQVLNRQNV 607
Query: 460 DKEPKEQLQKAIRD 473
E +LQK ++D
Sbjct: 608 PFEDYTRLQKRLKD 621
Score = 36.2 bits (82), Expect = 0.084
Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 54/303 (17%)
Query: 242 NQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE--NDLLQGTVEELQDRVLILERQGHD 299
N+H+ LQ E+K L + K+ + +L LEE +L++ T + + ++ IL Q
Sbjct: 61 NEHV----KLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQ--- 113
Query: 300 KDLQLHQSQLELQEVRLSCRQLQVKVEELTEE-RSLQSSAATSTSLLS------------ 346
L+L ++Q++ QE+ R+ ++E E+ R++ + + L
Sbjct: 114 -KLELLRAQIQ-QELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYAR 171
Query: 347 -----EIEQSMEAEELEQEREQLRLQLW------------EAYCQVRYLCSHLRGNDSAD 389
+I+ E LE+++E+LR QL + + YLC L+G ++
Sbjct: 172 ILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEV 231
Query: 390 SAVSTDSSMDESSETSSAKDVPAGSLR------TALNELKRLIQSIVDGMEPTVTLLSVE 443
+ + + E ++ +A+ + L +L K+ + +E + S +
Sbjct: 232 AELKAEKENSE-AQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQ 290
Query: 444 MTAL-----KEERDRLRVTSEDKEPKEQLQKAIRD-RDEAIAKKNAVELELAKCRMDMMS 497
T L K ER+ ++S+ KE K + I D + E K+ +E E K + ++
Sbjct: 291 NTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDG 350
Query: 498 LNS 500
L S
Sbjct: 351 LQS 353
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 75.9 bits (185), Expect = 1e-13
Identities = 95/433 (21%), Positives = 192/433 (44%), Gaps = 64/433 (14%)
Query: 128 SRQYEQMHKE---LTDKLEHLEQEKHELRRRFENREGEWEG-------RVSELESDVKQL 177
S++ EQ+ +E L KL+ LE E EL+ EN E + E +++E+++ V+ L
Sbjct: 207 SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSL 266
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
E E+Q +LR EK +Q SEQN L+++L +A LS +V L+ + +
Sbjct: 267 --EAEKQSANLRAERLEKE--LQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLE 322
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVE-----------EL 286
+ I+LE+ +A+ ++ +R + ++ L +N++L+ VE EL
Sbjct: 323 ITD-----IKLETARAKSELERERNK-IQSELDGLQSDNEILKAAVEHHKVLLVEKDREL 376
Query: 287 QDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLS 346
+V + +G+ K + L +LEL+ +++V+ + + Q S ++
Sbjct: 377 IRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMA 436
Query: 347 EIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSS 406
E E +E + +RL+L + + ++A + + + S
Sbjct: 437 E-------EITRKELQSVRLKLQQQIVTI-------------ENAEKEKNENSDLKQQIS 476
Query: 407 AKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRV----TSEDK- 461
+ + SL + N+L Q + + +E L E + + ++ ++ T E+K
Sbjct: 477 SLQIQVTSLAQSENDLLNSNQMLKEMVER----LKQECRNFRSQAEKAQLEAEKTLEEKQ 532
Query: 462 ----EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
E K +L + I DR+E + A + SL+ L +Q+K+ + + +
Sbjct: 533 IQWLEEKHKLHERITDREEKYNQAKEKLQRAAIAQKKRKSLHENKLKRLQEKVEVLEAKK 592
Query: 518 AWQDDMHRVIDRQ 530
+ ++V++RQ
Sbjct: 593 EELETENQVLNRQ 605
Score = 52.4 bits (124), Expect = 1e-06
Identities = 82/374 (21%), Positives = 150/374 (40%), Gaps = 48/374 (12%)
Query: 107 EKDLVLAARLGKALLERNQDMSRQYEQMHK---ELTDKLEHLEQEKHELRRRFENREGEW 163
E++ L +L KA E N S+ E H E+TD + K EL R + E
Sbjct: 289 EQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSEL 348
Query: 164 EGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQN-QRLLDQLSRASEVERQ 222
+G L+SD + L+ +E ++ L E DRE R VQ E+ Q+L+ E+E +
Sbjct: 349 DG----LQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELENR 404
Query: 223 LS--MQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ 280
L+ ++ + +R+ + +R + EI RK LQ
Sbjct: 405 LADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEI----TRKE---------------LQ 445
Query: 281 GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE-ERSLQSSAA 339
+LQ +++ +E +K+ E +++ LQ++V L + E L +S
Sbjct: 446 SVRLKLQQQIVTIENAEKEKN--------ENSDLKQQISSLQIQVTSLAQSENDLLNSNQ 497
Query: 340 TSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMD 399
++ ++Q + E+ QL + Q+++L + ++ +
Sbjct: 498 MLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAK 557
Query: 400 ESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSE 459
E + ++ SL N+LKRL + V +L + L+ E L +
Sbjct: 558 EKLQRAAIAQKKRKSLHE--NKLKRL--------QEKVEVLEAKKEELETENQVLNRQNV 607
Query: 460 DKEPKEQLQKAIRD 473
E +LQK ++D
Sbjct: 608 PFEDYTRLQKRLKD 621
Score = 36.2 bits (82), Expect = 0.084
Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 54/303 (17%)
Query: 242 NQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE--NDLLQGTVEELQDRVLILERQGHD 299
N+H+ LQ E+K L + K+ + +L LEE +L++ T + + ++ IL Q
Sbjct: 61 NEHV----KLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQ--- 113
Query: 300 KDLQLHQSQLELQEVRLSCRQLQVKVEELTEE-RSLQSSAATSTSLLS------------ 346
L+L ++Q++ QE+ R+ ++E E+ R++ + + L
Sbjct: 114 -KLELLRAQIQ-QELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYAR 171
Query: 347 -----EIEQSMEAEELEQEREQLRLQLW------------EAYCQVRYLCSHLRGNDSAD 389
+I+ E LE+++E+LR QL + + YLC L+G ++
Sbjct: 172 ILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEV 231
Query: 390 SAVSTDSSMDESSETSSAKDVPAGSLR------TALNELKRLIQSIVDGMEPTVTLLSVE 443
+ + + E ++ +A+ + L +L K+ + +E + S +
Sbjct: 232 AELKAEKENSE-AQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQ 290
Query: 444 MTAL-----KEERDRLRVTSEDKEPKEQLQKAIRD-RDEAIAKKNAVELELAKCRMDMMS 497
T L K ER+ ++S+ KE K + I D + E K+ +E E K + ++
Sbjct: 291 NTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDG 350
Query: 498 LNS 500
L S
Sbjct: 351 LQS 353
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 75.5 bits (184), Expect = 1e-13
Identities = 103/435 (23%), Positives = 186/435 (42%), Gaps = 42/435 (9%)
Query: 104 RQKEKDLVLAARLGKAL--LERNQDMSRQ--------YEQMHKELTDKLEHLEQEKHELR 153
RQ E++ +A + L L Q+++RQ EQ + L +L L E+ +L+
Sbjct: 774 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 833
Query: 154 RRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQL 213
+ + GR ELE Q + E +RQ L A REK + L++++ L QL
Sbjct: 834 EQLAQLSRQLSGREQELE----QARREAQRQVEALERAAREK----EALAKEHAGLAVQL 885
Query: 214 SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
A R LS + LR + S L +Q ++ L R+ +LE A L
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGS-------LFEVQRQLAQLEARREQLEAEGQALL 938
Query: 274 EENDLLQGTVEELQDRVLIL-ERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEER 332
+ L G + L+ +++ E+ DK+L + +E + S R+ + EE +
Sbjct: 939 LAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL 998
Query: 333 SLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLR-----GNDS 387
+ AA E E++ +L++E+E+L +L ++ + L+ G
Sbjct: 999 QREKEAAWRE---LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
Query: 388 ADSAVSTDSSMDESSETSSAKDV-----PAGSLRTALNELKRLIQSIVDGMEPTVTLLSV 442
A+S S+ ES +T+ ++ + ++ + KR QS + TV L+
Sbjct: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
Query: 443 EMTALKEERDRLRV--TSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNS 500
E+ L+ +R+ E + +EQ + + RD + + + +L L
Sbjct: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
Query: 501 QLLDAIQQKLNLSQQ 515
+LL+A Q+KL SQ+
Sbjct: 1176 ELLEA-QRKLRESQE 1189
Score = 65.9 bits (159), Expect = 1e-10
Identities = 86/369 (23%), Positives = 155/369 (42%), Gaps = 88/369 (23%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLE---QEKHELRRRFENREGEWEGRVSELESDV 174
+ L+ ++ ++ RQ ++ KL+ + Q + +L +R + + +++ R SELE +
Sbjct: 135 RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQL 194
Query: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQR----------LLDQLSRASEVERQLS 224
+ ELE+Q++ E ++ A+ L E+ QR L +QL +A + LS
Sbjct: 195 LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALS 254
Query: 225 MQVHALREDF---------------REKNS----STNQH---------IIRLESLQAEIK 256
+ + D+ RE+ S +N+H ++ L +E+K
Sbjct: 255 EDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVK 314
Query: 257 MLSDRK--------------------------RELEHRLSATLEENDLLQGTVEE-LQDR 289
M ++R R E R A LE+ LLQ +EE L+D+
Sbjct: 315 MFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDK 374
Query: 290 VLILERQGHDKDLQLHQSQLELQEVRLSCR--QLQVKVEELTEERSLQSSAATSTSLLSE 347
VL +KDL Q Q +L + LS R +L + V+ L E+++L+ +
Sbjct: 375 VL------REKDLAQQQMQSDLDKADLSARVTELGLAVKRL-EKQNLEKDQVN-----KD 422
Query: 348 IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
+ + +EA E + +EQ L+ + + L D A + +S S + S +
Sbjct: 423 LTEKLEALESLRLQEQAALETEDGEGLQQTL------RDLAQAVLSDSESGVQLSGSERT 476
Query: 408 KDVPAGSLR 416
D GSLR
Sbjct: 477 ADASNGSLR 485
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/452 (25%), Positives = 197/452 (43%), Gaps = 97/452 (21%)
Query: 159 REGEWEGRVSELESDVKQLQDELERQQIHLREADREKS--------RAVQELSEQNQRLL 210
RE E R ++ E D + Q +Q+ EA+R+ + +AV E SE+ +R +
Sbjct: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE-SEEARRSV 1570
Query: 211 DQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQA----------------- 253
D R S V+ +L++Q ++R RE+ ++ +Q SLQA
Sbjct: 1571 D--GRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 254 -EIKMLSDRKR---------------ELEHR-LSATLEENDL----LQGTVEELQDRVLI 292
E K+ D++R EL+ R L L+ + L + + LQDRV
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS 1688
Query: 293 LERQGHDKDLQLHQSQL-------ELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLL 345
L+RQ D +++ QL L +V S L+ KV LTE + S++ ST
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
Query: 346 S-EIEQSMEAEE-----LEQEREQLRLQLWEAYCQVRYL---CSHLRGN--DSADSAVST 394
+ +++++ A E L++ + R L EA Q L LRG D V
Sbjct: 1749 NLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA 1808
Query: 395 DSSMDESSET-SSAKDVPAGSLRTA--LNELKRLIQSIVDGMEPTVTLL-----SVEMTA 446
+ + + E ++ A +L T L + +RL+Q + ++ + L VE +A
Sbjct: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSA 1868
Query: 447 LKEERDRLRV-TSEDKEPKEQLQKAIRDRDEAIAKK-------NAVELELAKCRMDMMSL 498
L+ E+DR+ + + DK +E+L ++ D A+K ELELA+ + + L
Sbjct: 1869 LRLEKDRVALRRTLDKVEREKL-RSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
Query: 499 NSQL-------------LDAIQQKLNLSQQLE 517
+Q+ +DA QQ+L L Q++E
Sbjct: 1928 EAQVVVLEQSHSPAQLEVDAQQQQLELQQEVE 1959
Score = 62.0 bits (149), Expect = 1e-09
Identities = 104/447 (23%), Positives = 182/447 (40%), Gaps = 49/447 (10%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
+LL +R++ D R + L+R +D + Q H++ +++ L L R
Sbjct: 547 DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKS 606
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQ---RLLDQLS 214
N + + ++L+ E E+ Q E R++ R +E + Q R+ +L
Sbjct: 607 NLAHS----LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
Query: 215 RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR-------KRELEH 267
R+ QL + L ++ E + ++ ++ + LQAE +++ + ELE
Sbjct: 663 RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELEL 722
Query: 268 RLSATLEENDLLQGTVEELQDRVLILERQGHDK-DLQLHQSQLELQEVRLSCRQLQVKVE 326
++ E LQ ++ +L + E DK DL +QLE ++ L RQ Q + E
Sbjct: 723 SMTKLRAEEASLQDSLSKLS---ALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
Query: 327 --------ELTEERSLQSSAATS--TSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVR 376
E EE L+ A L EQ+ EA LEQ+ LR + + Q+
Sbjct: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA--LEQQLPTLRHERSQLQEQLA 837
Query: 377 YLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPT 436
L L G + E + + + V A L A E + L + G+
Sbjct: 838 QLSRQLSGREQE----------LEQARREAQRQVEA--LERAAREKEALAKEHA-GLAVQ 884
Query: 437 VTLLSVEMTALKEERDRLRVTSEDK-----EPKEQLQKAIRDRDEAIAKKNAVELELAKC 491
+ E L EE RLR+ E E + QL + R++ A+ A+ L
Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL 944
Query: 492 RMDMMSLNSQLLDAIQQKLNLSQQLEA 518
++ L Q++ A Q+K +L ++L A
Sbjct: 945 TGELAGLRQQII-ATQEKASLDKELMA 970
Score = 59.3 bits (142), Expect = 9e-09
Identities = 69/275 (25%), Positives = 120/275 (43%), Gaps = 31/275 (11%)
Query: 119 ALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQ 178
A LER+ + + +E K++ E + +RR + E R +LE + L+
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 179 DELERQQIHLREADRE-KSRAVQELSEQNQR------------------LLDQLSRASEV 219
EL+R ++ L +DRE +++A+Q+ + QR L L++ E
Sbjct: 1663 GELQRSRLGL--SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 220 ERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLL 279
E L +V L E + ++S N + LQ + ++ L+ RL A +
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 280 QGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQV-------KVEELTEER 332
+ L ++V L + D +LQ +++ +LQ++R RQ Q V++L +ER
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840
Query: 333 SLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQ 367
L S L +EAE+ E ER LRL+
Sbjct: 1841 RLLQERLGS---LQRALAQLEAEKREVERSALRLE 1872
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/483 (19%), Positives = 198/483 (40%), Gaps = 61/483 (12%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEW---------EGRVSELE 171
++R + + + +Q++K+LT+KLE LE + + + E +GE + +S+ E
Sbjct: 406 VKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE 465
Query: 172 SDVKQLQDEL--------------ERQQIHLREADREKSRAVQELSEQNQRLLDQLSRAS 217
S V+ E +R R + + R+ + L+
Sbjct: 466 SGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH 525
Query: 218 EVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEEND 277
+ +QV +R + +L ++E + L ++ + L + ++ ++
Sbjct: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
Query: 278 LLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEER----- 332
Q V+ L+ +L R+ + L +Q + +E+R +LQ EEL +R
Sbjct: 586 DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645
Query: 333 SLQSSAATSTSLLSEIEQS-MEAEELEQEREQLR---LQLWEAYCQVRYLCSHLRGN--D 386
+ + + E+E+S + E+LE +R L +++ EA + L+ +
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 387 SADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD---GMEPTVTLLSVE 443
A++ ++ E + + SL+ +L++L L +S+ + V L E
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 444 MTAL--------------KEERDRL-RVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELEL 488
+AL +EE++RL + E + ++ L+ ++R ++A + A+E +L
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQA---QEALEQQL 822
Query: 489 AKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCR 548
R + L QL +Q Q+LE + + R ++ L+ ++ AL +
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA------LERAAREKEALAK 876
Query: 549 GHS 551
H+
Sbjct: 877 EHA 879
Score = 57.0 bits (136), Expect = 5e-08
Identities = 99/415 (23%), Positives = 180/415 (43%), Gaps = 57/415 (13%)
Query: 150 HELRRRFENREGEWEGRVSELESDVKQLQDE------LERQQIHLR-------EADREKS 196
H+ + + ++ G +E L + KQL D LE Q LR +A +
Sbjct: 529 HKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQ 588
Query: 197 RAVQELSEQNQ---RLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQA 253
R VQ L N+ R L+ + +V +Q + ++ RE + + RLE Q
Sbjct: 589 REVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQE 648
Query: 254 EIKMLSDR-KRELE--HRLSATLE-ENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQL 309
+ R +RELE HR LE + +L + E+++ L R +D+ L +
Sbjct: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE---ALSRATLQRDM-LQAEKA 704
Query: 310 ELQEVRLSCRQLQVKVE-ELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQL 368
E+ E +V++E +T+ R+ ++S S S LS + +S+ ++L+ R +L+
Sbjct: 705 EVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
Query: 369 WEAYCQVRYLCSHLRGNDSADSAVSTDSSMDE-SSETSSAKDVPAGSLRTALNELKRLIQ 427
++ Q R + A A ++E E A+ GSLR A + L Q
Sbjct: 765 EKSALQGR----QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Query: 428 SIV------DGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKK 481
+ ++ + LS +++ ++E ++ R E + E L++A R++ EA+AK+
Sbjct: 821 QLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR--REAQRQVEALERAAREK-EALAKE 877
Query: 482 N---AVEL------------ELAKCRMDMMSLNSQLLDAIQQKLNLS---QQLEA 518
+ AV+L E + R++ +L L + +Q L +QLEA
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
Score = 57.0 bits (136), Expect = 5e-08
Identities = 92/404 (22%), Positives = 166/404 (41%), Gaps = 29/404 (7%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKL-EHLEQEKHELRRRFENREGEWEGRVSELESDVKQ 176
KA L++ M+++ Q +E L E + +L+R +E W ELE++ Q
Sbjct: 961 KASLDKEL-MAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWR----ELEAERAQ 1015
Query: 177 LQDELERQQIH-LREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFR 235
LQ +L+R+Q L + EK +E++ Q D+ +E E+Q ++ + +
Sbjct: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQE-RDEGLLLAESEKQQALSLKESEKTAL 1074
Query: 236 EKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDL--LQGTVEEL----QDR 289
+ +H + SL+ E + + R+ + R + ++L L+ EE
Sbjct: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE 1134
Query: 290 VLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIE 349
V L+ Q D Q E +E+R R L+ + L E L++ S
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE-LLEAQRKLRESQEGREV 1193
Query: 350 QSMEAEELE-------QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESS 402
Q EA EL +ERE LR E V+ S A+ ++ E +
Sbjct: 1194 QRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEA 1253
Query: 403 ETSSAKDVPAGSLRTALNELKRL---IQSIVDGMEPTVTLLSVEMTALKEERDRL--RVT 457
T+ K+ AG LRT L E++R + + + + +L E T L E L R+
Sbjct: 1254 RTAVGKE--AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 458 SEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQ 501
++ KE ++ + R + + ++E+ + ++ L Q
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQ 1355
Score = 54.3 bits (129), Expect = 3e-07
Identities = 87/433 (20%), Positives = 174/433 (40%), Gaps = 43/433 (9%)
Query: 116 LGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVK 175
L K L+E + +SR Q D L+ + E E + E E E +++L ++
Sbjct: 678 LAKELVEVREALSRATLQR-----DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA 732
Query: 176 QLQDELERQQIHLREADREK---SRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALRE 232
LQD L + ++K +R V +L E+ L + +RQ + RE
Sbjct: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR-------QRQAEQEATVARE 785
Query: 233 DFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLI 292
+ + + + L+ +++ + LE +L E +LQ+++
Sbjct: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER-------SQLQEQLAQ 838
Query: 293 LERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQ-- 350
L RQ ++ +L Q++ E Q RQ++ E+ +L A L E+
Sbjct: 839 LSRQLSGREQELEQARREAQ------RQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892
Query: 351 ---SMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
S EA L E+E L L+E Q+ L + ++ A+
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 408 KDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSED-----KE 462
+ + A + +L++ + + Q +V L + A +E+ RL+ E +
Sbjct: 953 QQIIATQEKASLDK-ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 463 PKEQLQKAI-RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQD 521
+ QLQ + R+++E +A+ A + EL++ ++ +L + + + + QQ + ++
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKE 1068
Query: 522 DMHRVIDRQLMDT 534
+ +LM T
Sbjct: 1069 SEKTALSEKLMGT 1081
Score = 47.4 bits (111), Expect = 4e-05
Identities = 68/291 (23%), Positives = 121/291 (41%), Gaps = 42/291 (14%)
Query: 101 SVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKL----EHLEQEKHELRRRF 156
S+ RQ V A L + +ER + E+ L DK+ E L Q L
Sbjct: 1688 SLQRQVADSEVKAGTL-QLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST- 1745
Query: 157 ENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRA 216
++ + ++ E D + LQ+ L+ + L EA ++ S L EQ Q L +++
Sbjct: 1746 RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS----SLGEQVQTLRGEVADL 1801
Query: 217 SEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR--------------K 262
+ Q+ LRE R++ + ++ LQ E ++L +R K
Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEK 1861
Query: 263 RELEHRLSATLEENDLLQGTVEELQ--------DRVLILERQGHDKDLQLHQSQLELQEV 314
RE+E ++ L+ T+++++ D V + +G D L ++LEL E
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGR-LDRTLTGAELELAEA 1920
Query: 315 RLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLR 365
+ +QL+ +V L + S E++ + EL+QE E+LR
Sbjct: 1921 QRQIQQLEAQVVVLEQSHS---------PAQLEVDAQQQQLELQQEVERLR 1962
Score = 45.4 bits (106), Expect = 1e-04
Identities = 61/249 (24%), Positives = 109/249 (43%), Gaps = 19/249 (7%)
Query: 94 SQDPELLSVIRQKEKDL---VLAARLGKALLERNQDMSRQY----EQMHKELTDKLEHLE 146
+Q L+ R K L + A + +L+ D +RQ + L ++++ L
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
Query: 147 QEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQN 206
E +L E + E EG++ +L ++Q Q E E ++ + +++ R +QE
Sbjct: 1796 GEVADL----ELQRVEAEGQLQQLREVLRQRQ-EGEAAALNTVQKLQDERRLLQERLGSL 1850
Query: 207 QRLLDQL-SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKREL 265
QR L QL + EVER ++++ R R + +R + LS K L
Sbjct: 1851 QRALAQLEAEKREVERS-ALRLEKDRVALRRTLDKVEREKLRSHE---DTVRLSAEKGRL 1906
Query: 266 EHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQL--HQSQLELQEVRLSCRQLQV 323
+ L+ E Q +++L+ +V++LE+ L++ Q QLELQ+ R Q
Sbjct: 1907 DRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQA 1966
Query: 324 KVEELTEER 332
+ E E R
Sbjct: 1967 QTERTLEAR 1975
Score = 38.5 bits (88), Expect = 0.017
Identities = 90/439 (20%), Positives = 165/439 (37%), Gaps = 68/439 (15%)
Query: 125 QDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENRE-GEWEGRVSELESDVKQLQDE--L 181
Q++ RQ + + E T L +E EL+ R E E E R L + L+ E L
Sbjct: 1283 QELRRQMKMLDSENT----RLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Query: 182 ERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQ-------LSMQVHALREDF 234
E + L+ A R+ E + +RLL L A E+Q L +++ A R +
Sbjct: 1339 EVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEA 1398
Query: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLS------------------------ 270
E + R + L+AE+ + ++R E +L
Sbjct: 1399 AELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVP 1458
Query: 271 ATLEENDLLQGTVEELQDRVLILERQGH------------DKDLQLHQSQLELQEVRLSC 318
+ + +G+ E L + G DL + L+E
Sbjct: 1459 GSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQEL 1518
Query: 319 RQLQVKVEELTEE-----RSLQSSAATSTSLLSEIEQSMEA-EELEQEREQLRLQLWEAY 372
R Q + +EL + R L A S S Q +A E E+ R + +L
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578
Query: 373 CQVRYLCSHLRGND-----SADSAVSTDSSMDESSETSSAKDVPAGSLR---TALNELKR 424
++ +R ++ + D + + S+ + A ++ T L KR
Sbjct: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
Query: 425 LIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNA- 483
++ ++D E L ++ +L+ E R R+ D+E + Q A++DR +++ ++ A
Sbjct: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ---ALQDRVDSLQRQVAD 1695
Query: 484 VELELAKCRMDMMSLNSQL 502
E++ ++ + LN L
Sbjct: 1696 SEVKAGTLQLTVERLNGAL 1714
Score = 34.7 bits (78), Expect = 0.24
Identities = 32/133 (24%), Positives = 59/133 (44%), Gaps = 10/133 (7%)
Query: 140 DKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAV 199
DK+E + HE R +G + ++ E ++ + Q ++++ + + ++ S A
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ 1942
Query: 200 QELSEQNQRLLDQLSRASEVERQLSMQVHALRE-DFREKNSSTNQHIIRLESLQAEIKML 258
E+ Q Q QL EVER S Q R + RE+ H R+ L+ ++ L
Sbjct: 1943 LEVDAQQQ----QLELQQEVERLRSAQAQTERTLEARER-----AHRQRVRGLEEQVSTL 1993
Query: 259 SDRKRELEHRLSA 271
+ ++ R SA
Sbjct: 1994 KGQLQQELRRSSA 2006
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 75.5 bits (184), Expect = 1e-13
Identities = 88/401 (21%), Positives = 185/401 (46%), Gaps = 36/401 (8%)
Query: 142 LEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQE 201
L+H Q++ ++ ++ R GE E ++LE V +L+ EL++Q RE+ EK R ++E
Sbjct: 907 LQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ----RESSAEKLRKMEE 962
Query: 202 LSEQNQRLLDQLSRASEVE-RQLSMQVHALREDFREKNSSTNQHIIRLE--------SLQ 252
E D L R +E + QV + ++E+ S + I+ L+ L
Sbjct: 963 KCESAAHEAD-LKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS 1021
Query: 253 AEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVL---ILERQGHDKDLQLHQSQL 309
+L K ELE + +A E L T EL + + +LE + + +L +
Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081
Query: 310 ELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIE-QSMEAEELEQEREQLRLQL 368
+LQE+R ++ Q+ +EE + +++ A EIE + E E++Q ++ +L
Sbjct: 1082 QLQELRDVLQKAQLSLEE--KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL 1139
Query: 369 WEAYCQVRYLCSHLRGN--DSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLI 426
+ QV +L +R + + + + ++++S + SL L K +
Sbjct: 1140 KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL 1199
Query: 427 QSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAK--KNAV 484
+ E + E++ LK+E +R ++ ++++ ++++++ IA K A+
Sbjct: 1200 RE----KEFIMLQNEQEISQLKKEIER------TQQRMKEMESVMKEQEQYIATQYKEAI 1249
Query: 485 EL--ELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
+L EL R + + +++L +A Q++ +++E ++
Sbjct: 1250 DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
Score = 67.8 bits (164), Expect = 3e-11
Identities = 91/448 (20%), Positives = 189/448 (42%), Gaps = 53/448 (11%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
+LL++ +Q E+ +V + + E Q++ + E++ T+ + E ++ FE
Sbjct: 698 QLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETN----INTEHEKICLAFE 753
Query: 158 NREGEWEGRVSELESDVKQLQDELER---------------------QQIHLREADREKS 196
+ + E+E +++L+ +LE+ +Q HL DR +
Sbjct: 754 KAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLT 813
Query: 197 RAVQELSEQNQR-------LLDQLSRASEVERQLSMQVHALRED----FREKNSSTNQHI 245
+ E+ ++N + L +Q+S + RQL + +E+ + + +
Sbjct: 814 ESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFE 873
Query: 246 IRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLH 305
+L+ E+ L + H L T E+N +LQ T+++ Q ++ + + +L+
Sbjct: 874 KQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQ--MLQQETIRNGELEDT 931
Query: 306 QSQLELQEVRLS---CRQLQVKVEELTEERSLQSSAATSTSLLSE--IEQSMEAEELEQE 360
Q++LE Q +L +Q + E+L + SAA L + IE + A +++ E
Sbjct: 932 QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIE 991
Query: 361 REQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALN 420
+Q + +L + ++ +L G + A D +D++ K A+
Sbjct: 992 MDQYKEELSKMEKEIMHL--KRDGENKAMHLSQLDMILDQTKTELEKK-------TNAVK 1042
Query: 421 ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSED-KEPKEQLQKAIRDRDEAIA 479
EL++L S + + V T L+ L+ T +E ++ LQKA +E
Sbjct: 1043 ELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYT 1102
Query: 480 KKNAVELELAKCRMDMMSLNSQLLDAIQ 507
+ EL +C+M++ +LL+ Q
Sbjct: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQ 1130
Score = 60.8 bits (146), Expect = 3e-09
Identities = 91/446 (20%), Positives = 199/446 (44%), Gaps = 84/446 (18%)
Query: 115 RLGKALLERNQD-MSRQYEQMHK-------ELTDKLEHLEQEKHELRRRFENREGEWE-- 164
++ +++ ++NQ M++QYE+ + EL KL +E E +L+ +R +++
Sbjct: 615 QVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLI 674
Query: 165 --------GRVSELESDVKQ-------LQDELERQQIHLREADREKSRAVQELSEQNQRL 209
S+LES++ + L+ +LE + + + + QEL E+N+++
Sbjct: 675 QEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI 734
Query: 210 LDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRL 269
+ + ++ + ++ E++ + I RLE A+++ + +E E +
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE---AQLEKKDQQFKEQEKTM 791
Query: 270 SATLEENDLLQGTVEELQDRVLI-----LERQGHDKDLQLHQSQLELQEVRLSCRQLQVK 324
S ++ Q +E L DR+L ++++ KD L Q ++ E + RQL
Sbjct: 792 SMLQQDIICKQHHLESL-DRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA 850
Query: 325 VEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRG 384
+E EE L L+++E + E E +QL+ + E YC + L
Sbjct: 851 LEICKEELVLH---------LNQLEGNKEKFE-----KQLKKKSEEVYCLQKEL------ 890
Query: 385 NDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ--SIVDG-MEPTVTLLS 441
+ S+ E+SE + L+ L + ++++Q +I +G +E T T L
Sbjct: 891 -------KIKNHSLQETSEQNVI-------LQHTLQQQQQMLQQETIRNGELEDTQTKLE 936
Query: 442 VEMTALKEERDRLRVTSEDK--EPKEQLQKAIRDRD-------EAIAKKNAVELELAKCR 492
+++ L++E + R +S +K + +E+ + A + D E V++E+ + +
Sbjct: 937 KQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYK 996
Query: 493 MDMMSLNSQLL----DAIQQKLNLSQ 514
++ + +++ D + ++LSQ
Sbjct: 997 EELSKMEKEIMHLKRDGENKAMHLSQ 1022
Score = 60.1 bits (144), Expect = 5e-09
Identities = 87/394 (22%), Positives = 161/394 (40%), Gaps = 46/394 (11%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEG---RVSELESDV 174
K LE+ + ++ E++ +L Q++ L +N GE + ++ EL +
Sbjct: 1031 KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL 1090
Query: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLL--DQLSRASEVE-RQLSMQVHALR 231
++ Q LE + +++ E E+ ++ Q LL DQ + E +Q + QV L
Sbjct: 1091 QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLD 1150
Query: 232 EDFREKNSSTNQHIIRLE------------------SLQAEIKMLSDRKRELEHRLSATL 273
RE Q II+LE SL +++ ++ RE E +
Sbjct: 1151 MTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNE 1210
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQL---HQSQLEL-QEVRLSCRQLQVKVEELT 329
+E L+ +E Q R+ +E +++ + ++ ++L QE+RL+ Q+Q EL
Sbjct: 1211 QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270
Query: 330 EERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSAD 389
E R Q A LS + M ++L +E++ L E + +HL A+
Sbjct: 1271 EARHQQVQAQREIERLSSELEDM--KQLSKEKDAHGNHLAEELGASKVREAHLEARMQAE 1328
Query: 390 SAVSTDSSMDESSETSSAKDV-PAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALK 448
S+E S K+ + N K I + D + +V L+ ++ K
Sbjct: 1329 -------IKKLSAEVESLKEAYHMEMISHQENHAKWKISA--DSQKSSVQQLNEQLEKAK 1379
Query: 449 EERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKN 482
E + E ++ L + ++DR+E I N
Sbjct: 1380 LELE------EAQDTVSNLHQQVQDRNEVIEAAN 1407
Score = 57.0 bits (136), Expect = 5e-08
Identities = 93/467 (19%), Positives = 190/467 (40%), Gaps = 66/467 (14%)
Query: 120 LLERNQDMSRQYEQMHKELTD---KLEHLEQEKHE------LRRRFENREGEWEGRVSEL 170
L+ +N + ++E +H ELT K+ LE + + L + N E E VS
Sbjct: 248 LVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAE----VSAQ 303
Query: 171 ESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHAL 230
+ +++ +++LE+ Q + E ++ + +E + LL+Q + ERQ + ++
Sbjct: 304 DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNA 363
Query: 231 REDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRV 290
E + + +LE +QAE ++L E E L + +E L++++
Sbjct: 364 EELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKL 423
Query: 291 LILERQGHDKDLQLH-------QSQLELQEVRLSCRQLQVKVEE-----------LTEER 332
L+ + ++ +L + +L E R S +L+ ++E + E R
Sbjct: 424 RQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
Query: 333 SLQSSAATSTSLLSEIEQSMEAEELE-QEREQLRLQL---WEAYCQVRYLCSHLRGNDSA 388
L+ A L +Q +E+ +E + E++ QL E + YL +
Sbjct: 484 ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY------- 536
Query: 389 DSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALK 448
S + D A + LR L + IQ + + T LS +
Sbjct: 537 -QMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL--TANQLSQSLITCN 593
Query: 449 EERDRLRVTSEDKEPKE----QLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLD 504
+ ++ +++S + EP + Q+ ++++D+++ K E E + + L ++L+
Sbjct: 594 DSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQ-YEKERQRLVTGIEELRTKLI- 651
Query: 505 AIQQKLNLSQQLEAWQDDM-----HRVIDRQLMDTHLKERSQPAAAL 546
Q+EA D+ HR QL+ L E++ ++ L
Sbjct: 652 ----------QIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL 688
Score = 41.2 bits (95), Expect = 0.003
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 74 EHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQ------KEKDLV---LAARLGKALLERN 124
E Q LAE Q ++ E LS + KEKD LA LG + + R
Sbjct: 1260 EQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKV-RE 1318
Query: 125 QDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQ 184
+ + + K+L+ ++E L++ H + +W+ +S V+QL ++LE+
Sbjct: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
Query: 185 QIHLREADREKSRAVQELSEQNQ 207
++ L EA S Q++ ++N+
Sbjct: 1379 KLELEEAQDTVSNLHQQVQDRNE 1401
Score = 38.9 bits (89), Expect = 0.013
Identities = 31/128 (24%), Positives = 56/128 (43%), Gaps = 9/128 (7%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE 180
+ER +Q+ KE HL +E + R + E + + +L ++V+ L++
Sbjct: 1283 IERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEA 1342
Query: 181 LERQQIHLRE--------ADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALRE 232
+ I +E AD +KS +VQ+L+EQ ++ +L A + L QV E
Sbjct: 1343 YHMEMISHQENHAKWKISADSQKS-SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNE 1401
Query: 233 DFREKNSS 240
N +
Sbjct: 1402 VIEAANEA 1409
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 75.1 bits (183), Expect = 2e-13
Identities = 102/471 (21%), Positives = 204/471 (43%), Gaps = 68/471 (14%)
Query: 104 RQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKL---EHLEQEKHEL---RRRFE 157
R+KE + AR + LE ++ RQ +Q+ ++ D + + + + HEL +R E
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQ---RLLDQLS 214
+ E ++ ELE +++ +D R +++++ + R +Q EQN+ RLL +
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 215 RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE 274
R E E + + AL ++K I L+ L+A+I+ + + E+ +L
Sbjct: 1599 RELEAELEDERKQRALAVASKKKME------IDLKDLEAQIEAANKARDEVIKQLRKLQA 1652
Query: 275 ENDLLQGTVEELQ---DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEE 331
+ Q +EE + D + ++ K L L+LQE S + + E+ +E
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 332 RS--LQSSAATSTSLLSEIEQSMEA------EELEQEREQLRL---QLWEAYCQVRYLCS 380
+ + +SA+ ++LL E ++ +EA EELE+E+ + L + + QV L +
Sbjct: 1713 LADEITNSASGKSALLDE-KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 381 HLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLL 440
L SA A +D++ + + L+ L EL+ ++S + T++ L
Sbjct: 1772 ELAAERSA--AQKSDNARQQLERQNK-------ELKAKLQELEGAVKS---KFKATISAL 1819
Query: 441 SVEMTALKEERDR-----------------------LRVTSEDKEP---KEQLQKAIRDR 474
++ L+E+ ++ ++V E + KEQ++KA
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHR 525
+ + E E + L +L DA + LS+++ ++ + R
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 73.9 bits (180), Expect = 4e-13
Identities = 106/490 (21%), Positives = 201/490 (41%), Gaps = 71/490 (14%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + +K + L+ + L+ ++ + E+M L K + LE+ H+L R E
Sbjct: 875 LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE 934
Query: 160 EGE---WEGRVSELESDVKQLQDELE-----RQQIHLREADRE-KSRAVQE----LSEQN 206
E + ++++ ++ L+++L+ RQ++ L + E K + ++E L +QN
Sbjct: 935 EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 207 QRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELE 266
+ + + + + S Q+ E + N+ + + L+ +K ++ELE
Sbjct: 995 SKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
Query: 267 HRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQ-------------- 312
+ L G +LQD++ L+ Q + LQL + + ELQ
Sbjct: 1055 -------KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 313 EVRLSCRQLQVKVEELTEE-RSLQSSAATSTSLLSEIEQSMEAEELEQE--------REQ 363
R+LQ ++ EL E+ S ++S + ++ + +EA + E E +++
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 364 LRLQLWEAYCQVRYLCSHLRGNDSA---DSAVSTDSSMDESSE-TSSAKDVPAG------ 413
LR + + +++ N A D ++++E SE AK A
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 414 SLRTALNELK---RLIQSIVDGMEPTVTLLSV---EMTALKEERDRLRVTSEDKEPKEQL 467
L T EL +++Q + E L E+ A E DRLRV +K K Q
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ- 1286
Query: 468 QKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA-------IQQKLNLSQQLEAWQ 520
+ D E + K D SL SQL D +QKLNLS ++ +
Sbjct: 1287 ----NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 521 DDMHRVIDRQ 530
++ + + ++Q
Sbjct: 1343 EEKNSLQEQQ 1352
Score = 70.5 bits (171), Expect = 4e-12
Identities = 101/462 (21%), Positives = 194/462 (41%), Gaps = 56/462 (12%)
Query: 98 ELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
EL + I + ++D ++ +D+S + E + EL D L+ ++ ELR + E
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ-ELRTKRE 1173
Query: 158 NREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRL------LD 211
V+EL+ K L++E + + +++ + + A++ELSEQ ++ L+
Sbjct: 1174 QE-------VAELK---KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 212 QLSRASEVE-RQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLS 270
+ + E + ++L+ +V L++ E + +++ L A++ + EL + S
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 271 ATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE 330
E D + +EE + + + + + QL +Q LQE L ++ +L E
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 331 ER-SLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSAD 389
E+ SLQ EQ E EE + E+ L L + D
Sbjct: 1344 EKNSLQ-------------EQQEEEEEARKNLEKQVLALQSQLADTK---------KKVD 1381
Query: 390 SAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKE 449
+ T S++E+ + KD A S R L D +E T L E+ L
Sbjct: 1382 DDLGTIESLEEAKK-KLLKDAEALSQRLEEKAL------AYDKLEKTKNRLQQELDDLTV 1434
Query: 450 ERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKC-----RMDMMSLNSQLLD 504
+ D R + + E K++ + +++I+ + A E + A+ +SL L +
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 505 AIQQKLNL---SQQLEAWQDDMHRVIDRQLMDTHLKERSQPA 543
A++ K ++QL A +D+ D + H E+S+ A
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/363 (23%), Positives = 164/363 (45%), Gaps = 43/363 (11%)
Query: 196 SRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEI 255
+R +EL +++ LL + ++VE +L ++ EKN I E LQAE
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKN-------ILAEQLQAET 900
Query: 256 KMLSDRKRELEHRLSATLEENDL----LQGTVEELQDRVLILERQGHDKDLQLHQSQLEL 311
++ ++ + E+ RL+A +E + L+ VEE ++R IL Q K +Q H LE
Sbjct: 901 ELFAEAE-EMRARLAAKKQELEEILHDLESRVEEEEERNQIL--QNEKKKMQAHIQDLEE 957
Query: 312 QEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEA 371
Q + ++++E++T E ++ L + + ++ ++L ++R A
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI--------A 1009
Query: 372 YCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD 431
C + + + A + + + E ++ R L + KR + D
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE----KTRQELEKAKRKL----D 1061
Query: 432 GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAI-RDRDEAIAKKNAVEL---- 486
G T L ++ L+ + D L++ KE E+LQ A+ R DE + K NA+++
Sbjct: 1062 G---ETTDLQDQIAELQAQIDELKLQLAKKE--EELQGALARGDDETLHKNNALKVVREL 1116
Query: 487 --ELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLK-ERSQPA 543
++A+ + D S + A +QK +LS++LEA + ++ +D L+ +R Q
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 544 AAL 546
A L
Sbjct: 1177 AEL 1179
Score = 64.7 bits (156), Expect = 2e-10
Identities = 90/436 (20%), Positives = 194/436 (44%), Gaps = 49/436 (11%)
Query: 137 ELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDE-------LERQQIHLR 189
++T + E L+ + EL + + ++ + EG + E+E +QL +E L+ +
Sbjct: 846 QVTRQEEELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ ++R + E + L D SR E E +++ + L E E+
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A+IK + + LE + S ++E L++ + E + + E +
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ--LAEEEEKA 1022
Query: 300 KDLQLHQSQLELQEVRLSCRQLQVKVEELTE---ERSLQSSAATSTSLLSEIEQSMEAEE 356
K+L +++ QEV +S + ++K EE T E++ + +T L +I E
Sbjct: 1023 KNLAKIRNK---QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI------AE 1073
Query: 357 LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSA---DSAV-------STDSSMDESSETSS 406
L+ + ++L+LQL + +++ + RG+D ++A+ + + + E E+
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALA--RGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 407 AKDVPAGSLRTALN-ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKE 465
A A + L+ EL+ L + D ++ T + +E + + E+ + E
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 466 QLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKL----NLSQQLEAWQD 521
+ +R R ++ + +LE AK + N Q L+ ++L + QQ++A +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 522 DMHRVIDRQLMDTHLK 537
+ +D Q+ + H K
Sbjct: 1252 HKRKKLDAQVQELHAK 1267
Score = 58.5 bits (140), Expect = 2e-08
Identities = 83/427 (19%), Positives = 170/427 (39%), Gaps = 64/427 (14%)
Query: 118 KALLERNQDMSRQYEQMHK-------ELTDKLEHLEQEKHELRRRFENREGEWEGRVSEL 170
+AL +R ++ + Y+++ K EL D L+ ++ ++ E ++ +++ ++E
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR-QVASNLEKKQKKFDQLLAEE 1460
Query: 171 ESDVKQLQDELERQQIHLREAD----------REKSRAVQELSEQNQRLLDQLSRASEVE 220
+S + +E +R + RE + E A +E QN++L + +
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Query: 221 RQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ 280
+ VH L + R + +LE L+ E++ D K LE + A
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM-------- 1572
Query: 281 GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAAT 340
+ ++DLQ Q E ++ RL +Q++ EL +ER ++ A
Sbjct: 1573 --------------KAQFERDLQTRDEQNE-EKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 341 STSLLSEIEQSMEA--EELEQEREQLRLQLWEAYCQVR-YLCSHLRGNDSADSAVSTDSS 397
S + + +EA E + R+++ QL + Q++ Y S D +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 398 MDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRV- 456
++ ++ A+ + + +R + D + +T + +AL +E+ RL
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR 1737
Query: 457 ---TSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLL---DAIQQKL 510
E+ E ++ + + DR K + + +LN++L A Q+
Sbjct: 1738 IAQLEEELEEEQSNMELLNDR-------------FRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 511 NLSQQLE 517
N QQLE
Sbjct: 1785 NARQQLE 1791
Score = 52.4 bits (124), Expect = 1e-06
Identities = 69/306 (22%), Positives = 130/306 (42%), Gaps = 43/306 (14%)
Query: 54 LALEEELALLAAGERPSDPGEHPQAEPGSLAE-----GAGPQPPPSQDPELLSVIRQKEK 108
L L+EELA R H + E LA+ +G + L + I Q E+
Sbjct: 1690 LQLQEELASSERARR------HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 109 DLVLAARLGKALLERNQDMSRQYEQMHKELT----------DKLEHLEQEKHELRRRFEN 158
+L + L +R + + Q + ++ EL + + LE++ EL+ + +
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE 1803
Query: 159 REG----EWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLS 214
EG +++ +S LE+ + QL+++LE+ + ++ A +L + ++ L ++
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQ--------EAKERAAANKLVRRTEKKLKEIF 1855
Query: 215 RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE 274
E ER+ + Q +E + N+ Q +LE + E + +R+L+ L E
Sbjct: 1856 MQVEDERRHADQ---YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Query: 275 ENDLLQGTVEELQDRVL----ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTE 330
N+ L V L++R+ I QLH LE + LS + K ++ E
Sbjct: 1913 ANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH---LEGASLELSDDDTESKTSDVNE 1969
Query: 331 ERSLQS 336
+ QS
Sbjct: 1970 TQPPQS 1975
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 74.7 bits (182), Expect = 2e-13
Identities = 106/486 (21%), Positives = 226/486 (46%), Gaps = 63/486 (12%)
Query: 96 DPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKEL---------TDKLE--- 143
D E L + R E + ++ + LE N+++ + EQ+ K L T++LE
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 144 -HLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQEL 202
L+ E L++ EN ++ +LES+++ L+ E + Q +L E + S+ +++L
Sbjct: 759 QGLDIENQRLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEEL-KISSKRLEQL 813
Query: 203 SEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR- 261
++N+ L + S+ + ++QL + LR+ K+++ ++ +++ +L+ E K LS
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Query: 262 --KRELEHRLSATLEEN-DLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC 318
+E RL +EN +L++ +++ V + E +K L+ Q +L+++
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK-LKTQQMNNDLEKLTHEL 932
Query: 319 RQLQVKVEELT-EERSLQSS--AATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAY-CQ 374
++ + E L +E+S S + L S +++S+E +E + + RL+ Y Q
Sbjct: 933 EKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992
Query: 375 VRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGME 434
+R ++ N A + M +SS S +D N+ +R + E
Sbjct: 993 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGED----------NKWER------ESQE 1036
Query: 435 PTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQK-------------AIRDRDEAIAKK 481
T LL V+ ++ ER+ + +E + K QL++ A++ + ++ ++
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Query: 482 N-AVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVID-----RQLMDTH 535
N ++ + AK +++ +LNSQ + Q L Q + +++ VI + L D+
Sbjct: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Query: 536 LKERSQ 541
+K+ +
Sbjct: 1157 IKDHEK 1162
Score = 60.8 bits (146), Expect = 3e-09
Identities = 64/256 (25%), Positives = 130/256 (50%), Gaps = 27/256 (10%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQL 177
K +++ + ++ + +EL ++L HLE+E L+++ N + E ++ LE Q
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE-KIEALE----QE 664
Query: 178 QDELERQQIHLR---EADREKSRAVQELSEQNQRLLD---QLSRASEVERQLSMQVHALR 231
ELER+ L+ ++ + + ++ L ++N +L + +L R E + SM++ L+
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 232 EDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVL 291
+ +E S Q LE L+A K + LE EN LQ T+E ++
Sbjct: 725 LENKELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 292 ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS 351
LE + D +++ Q L+E+++S ++L+ ++E+ E +SL+ S++E+
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLE-QLEK--ENKSLEQET-------SQLEK- 829
Query: 352 MEAEELEQEREQLRLQ 367
+ ++LE+E ++LR Q
Sbjct: 830 -DKKQLEKENKRLRQQ 844
Score = 59.3 bits (142), Expect = 9e-09
Identities = 81/381 (21%), Positives = 162/381 (42%), Gaps = 75/381 (19%)
Query: 186 IHLREADREKSRAVQELSEQNQRLLDQLSRASEVE---RQLSMQVHALRED------FRE 236
+ L +A + R QEL E+ ++LLD ++E ++L + L D +R+
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 237 KNSSTNQHIIRLESLQAEIKMLSDRKRELEH---RLSATLEENDLLQGTVEELQDRVLIL 293
+ + + +R++ L++E+ +R ++E R+ E+N +L T L+D+ L
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ-LEG 369
Query: 294 ERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSME 353
R DK +L + L QL+ K+ ++ ER + +IE+ ME
Sbjct: 370 TRARSDKLHELEKENL----------QLKAKLHDMEMERDMDR---------KKIEELME 410
Query: 354 AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAG 413
E + L++ + S D ++ +++ S TS + P
Sbjct: 411 --------ENMTLEMAQ--------------KQSMDESLHLGWELEQISRTSELSEAPQK 448
Query: 414 SLRTALNEL--KRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAI 471
SL +NEL RL++ ++ T T+ + T E + ++ +KE ++L K
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-NQRLSK-- 505
Query: 472 RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVI---- 527
K +E E+ + + + + + D +++K L + +E +++ R I
Sbjct: 506 --------KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 528 --DRQLMDT--HLKERSQPAA 544
+ L T L++RSQ +A
Sbjct: 558 QENEHLNQTVSSLRQRSQISA 578
Score = 55.8 bits (133), Expect = 1e-07
Identities = 96/419 (22%), Positives = 180/419 (42%), Gaps = 55/419 (13%)
Query: 126 DMSRQYEQMH--KELTDKLEHLEQEKHELRRRFENREGEWEG------RVSELESDVKQL 177
++SR E++H + ++E L+++ L E + EG ++ ELE + QL
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
+ +L ++ R+ DR+K ++EL E+N L ++ + L ++ E+
Sbjct: 388 KAKLHDMEME-RDMDRKK---IEELMEENMTLEMAQKQSMDESLHLGWEL--------EQ 435
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE-ENDLLQGTVEELQDRVLILERQ 296
S T+ E +A K L EL LE EN L TVEEL+ V +E
Sbjct: 436 ISRTS------ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 297 GHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEE 356
K L++ E + RLS + ++ E + E++SLQ+ S L+ E Q + E
Sbjct: 490 A-SKILKM-----EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
Query: 357 LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLR 416
+E + ++++ E + N+ + VS+ + S + KD+ +
Sbjct: 544 TLRENSERQIKILE------------QENEHLNQTVSSLRQRSQISAEARVKDIEKEN-- 589
Query: 417 TALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSED----KEPKEQLQKAIR 472
L+E + S + +E + E+ KE+ +R + ++ E LQK I
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 473 DRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQL 531
+ K A+E E ++ + N +L + NL+ QLE+ + + ++ + L
Sbjct: 650 NLKITCEKIEALEQENSELERE----NRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Score = 45.8 bits (107), Expect = 1e-04
Identities = 92/450 (20%), Positives = 181/450 (40%), Gaps = 62/450 (13%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRR-----RFENR 159
++EK L ARL E + + ++Q Q K + E L+Q + E R
Sbjct: 972 KEEKIAALEARL-----EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
Query: 160 EGEWEGRVSELESDVKQLQD---ELERQQIHLREADREKSRAVQELSEQNQRLLDQ---L 213
+ +WE E ++ +++D E+ER L+ + +++L QN L Q L
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
Query: 214 SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
R + ++ + + + +NS+ N L + A++ + ++ LE+ + +
Sbjct: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI---QQSSLENENESVI 1143
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCR-QLQVKVEEL-TEE 331
+E + L+ + L + H+K LH+ Q E +S L+ + L E
Sbjct: 1144 KEREDLKSLYDSLI--------KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
Query: 332 RSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYC-QVRYLCSHLRGNDSADS 390
R L+ ++E + ++EQE+ L + E + + LC ND +
Sbjct: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE---NDRLNH 1252
Query: 391 AVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEE 450
T S + + +E L+T LK S+++ + T L E + LKE+
Sbjct: 1253 ---TYSQLLKETEV----------LQTDHKNLK----SLLNNSKLEQTRLEAEFSKLKEQ 1295
Query: 451 RDRLRVT-----------SEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLN 499
+L +T S+ K E+ + + D+ + + +N LE D+ +
Sbjct: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1355
Query: 500 S-QLLDAIQQKLNLSQQLEAWQDDMHRVID 528
Q +D + + ++LE D ++ D
Sbjct: 1356 QRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1385
Score = 37.7 bits (86), Expect = 0.029
Identities = 51/257 (19%), Positives = 113/257 (43%), Gaps = 45/257 (17%)
Query: 101 SVIRQKEKDLVLAARL---GKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
S++ Q + L+ + L +++++ +D+ Y+ + K+ +KLE L + +
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLI 1178
Query: 158 NREGEWEGRVSELESDVKQLQD---ELERQQIHLREADR----EKSRAVQE------LSE 204
++ G + LE + + L+D +L +Q+ L + ++ E+ + + E ++
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
Query: 205 QNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE 264
+ ++L + R + QL + L+ D + S N + L+AE L ++ ++
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
Query: 265 LE---HRLSATLEENDLLQGTVEE-------------LQDRVL------------ILERQ 296
L+ +L+ E L+G +EE LQ+R L + +RQ
Sbjct: 1299 LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Query: 297 GHDKDLQLHQSQLELQE 313
DK +L + + +L+E
Sbjct: 1359 YIDKLNELRRQKEKLEE 1375
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/492 (21%), Positives = 226/492 (45%), Gaps = 76/492 (15%)
Query: 96 DPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKEL---------TDKLE--- 143
D E L + R E + ++ + LE N+++ + EQ+ K L T++LE
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 144 -HLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQEL 202
L+ E L++ EN ++ +LES+++ L+ E + Q +L E + S+ +++L
Sbjct: 759 QGLDIENQRLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEEL-KISSKRLEQL 813
Query: 203 SEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR- 261
++N+ L + S+ + ++QL + LR+ K+++ ++ +++ +L+ E K LS
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Query: 262 --KRELEHRLSATLEEN-DLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC 318
+E RL +EN +L++ +++ V + E L +L+ Q++
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE--------DLVSEKLKTQQMNNDL 925
Query: 319 RQLQVKVEE--LTEERSLQSSAAT-------STSLLSEIEQSMEAEELEQEREQLRLQLW 369
+L ++E+ L +ER L +T + L S +++S+E +E + + RL+
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 370 EAY-CQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQS 428
Y Q+R ++ N A + M +SS S +D N+ +R
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED----------NKWER---- 1031
Query: 429 IVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQK-------------AIRDRD 475
+ E T LL V+ ++ ER+ + +E + K QL++ A++ +
Sbjct: 1032 --ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Query: 476 EAIAKKN-AVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVID-----R 529
++ ++N ++ + AK +++ +LNSQ + Q L Q + +++ VI +
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
Query: 530 QLMDTHLKERSQ 541
L D+ +K+ +
Sbjct: 1150 SLYDSLIKDHEK 1161
Score = 63.2 bits (152), Expect = 6e-10
Identities = 88/416 (21%), Positives = 189/416 (45%), Gaps = 50/416 (12%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQL 177
K +++ + ++ + +EL ++L HLE+E L+++ N + E ++ LE Q
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE-KIEALE----QE 664
Query: 178 QDELERQQIHLR---EADREKSRAVQELSEQNQRLLD---QLSRASEVERQLSMQVHALR 231
ELER+ L+ ++ + + ++ L ++N +L + +L R E + SM++ L+
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 232 EDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVL 291
+ +E S Q LE L+A K + LE EN LQ T+E ++
Sbjct: 725 LENKELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 292 ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS 351
LE + D +++ Q L+E+++S ++L+ ++E+ E +SL+ S++E+
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLE-QLEK--ENKSLEQET-------SQLEK- 829
Query: 352 MEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVP 411
+ ++LE+E ++LR Q + ++ ++ V + E+ S +
Sbjct: 830 -DKKQLEKENKRLRQQ------------AEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 412 AGS---LRTALNELKRLIQSIVDGMEPTVT----LLSVEMTALKEERDRLRVTSEDKEPK 464
S L+ E K L++ ++ VT L+S ++ + D ++T E ++
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 465 EQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKL----NLSQQL 516
++ + D + +E +L + + + + A++ +L N +QQL
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 992
Score = 59.3 bits (142), Expect = 9e-09
Identities = 81/381 (21%), Positives = 162/381 (42%), Gaps = 75/381 (19%)
Query: 186 IHLREADREKSRAVQELSEQNQRLLDQLSRASEVE---RQLSMQVHALRED------FRE 236
+ L +A + R QEL E+ ++LLD ++E ++L + L D +R+
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 237 KNSSTNQHIIRLESLQAEIKMLSDRKRELEH---RLSATLEENDLLQGTVEELQDRVLIL 293
+ + + +R++ L++E+ +R ++E R+ E+N +L T L+D+ L
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ-LEG 369
Query: 294 ERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSME 353
R DK +L + L QL+ K+ ++ ER + +IE+ ME
Sbjct: 370 TRARSDKLHELEKENL----------QLKAKLHDMEMERDMDR---------KKIEELME 410
Query: 354 AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAG 413
E + L++ + S D ++ +++ S TS + P
Sbjct: 411 --------ENMTLEMAQ--------------KQSMDESLHLGWELEQISRTSELSEAPQK 448
Query: 414 SLRTALNEL--KRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAI 471
SL +NEL RL++ ++ T T+ + T E + ++ +KE ++L K
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-NQRLSK-- 505
Query: 472 RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVI---- 527
K +E E+ + + + + + D +++K L + +E +++ R I
Sbjct: 506 --------KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 528 --DRQLMDT--HLKERSQPAA 544
+ L T L++RSQ +A
Sbjct: 558 QENEHLNQTVSSLRQRSQISA 578
Score = 55.8 bits (133), Expect = 1e-07
Identities = 96/419 (22%), Positives = 180/419 (42%), Gaps = 55/419 (13%)
Query: 126 DMSRQYEQMH--KELTDKLEHLEQEKHELRRRFENREGEWEG------RVSELESDVKQL 177
++SR E++H + ++E L+++ L E + EG ++ ELE + QL
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
+ +L ++ R+ DR+K ++EL E+N L ++ + L ++ E+
Sbjct: 388 KAKLHDMEME-RDMDRKK---IEELMEENMTLEMAQKQSMDESLHLGWEL--------EQ 435
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE-ENDLLQGTVEELQDRVLILERQ 296
S T+ E +A K L EL LE EN L TVEEL+ V +E
Sbjct: 436 ISRTS------ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 297 GHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEE 356
K L++ E + RLS + ++ E + E++SLQ+ S L+ E Q + E
Sbjct: 490 A-SKILKM-----EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
Query: 357 LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLR 416
+E + ++++ E + N+ + VS+ + S + KD+ +
Sbjct: 544 TLRENSERQIKILE------------QENEHLNQTVSSLRQRSQISAEARVKDIEKEN-- 589
Query: 417 TALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSED----KEPKEQLQKAIR 472
L+E + S + +E + E+ KE+ +R + ++ E LQK I
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 473 DRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQL 531
+ K A+E E ++ + N +L + NL+ QLE+ + + ++ + L
Sbjct: 650 NLKITCEKIEALEQENSELERE----NRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Score = 45.8 bits (107), Expect = 1e-04
Identities = 92/450 (20%), Positives = 181/450 (40%), Gaps = 62/450 (13%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRR-----RFENR 159
++EK L ARL E + + ++Q Q K + E L+Q + E R
Sbjct: 971 KEEKIAALEARL-----EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 160 EGEWEGRVSELESDVKQLQD---ELERQQIHLREADREKSRAVQELSEQNQRLLDQ---L 213
+ +WE E ++ +++D E+ER L+ + +++L QN L Q L
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Query: 214 SRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
R + ++ + + + +NS+ N L + A++ + ++ LE+ + +
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI---QQSSLENENESVI 1142
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCR-QLQVKVEEL-TEE 331
+E + L+ + L + H+K LH+ Q E +S L+ + L E
Sbjct: 1143 KEREDLKSLYDSLI--------KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1194
Query: 332 RSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYC-QVRYLCSHLRGNDSADS 390
R L+ ++E + ++EQE+ L + E + + LC ND +
Sbjct: 1195 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE---NDRLNH 1251
Query: 391 AVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEE 450
T S + + +E L+T LK S+++ + T L E + LKE+
Sbjct: 1252 ---TYSQLLKETEV----------LQTDHKNLK----SLLNNSKLEQTRLEAEFSKLKEQ 1294
Query: 451 RDRLRVT-----------SEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLN 499
+L +T S+ K E+ + + D+ + + +N LE D+ +
Sbjct: 1295 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1354
Query: 500 S-QLLDAIQQKLNLSQQLEAWQDDMHRVID 528
Q +D + + ++LE D ++ D
Sbjct: 1355 QRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1384
Score = 37.7 bits (86), Expect = 0.029
Identities = 51/257 (19%), Positives = 113/257 (43%), Gaps = 45/257 (17%)
Query: 101 SVIRQKEKDLVLAARL---GKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFE 157
S++ Q + L+ + L +++++ +D+ Y+ + K+ +KLE L + +
Sbjct: 1119 SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLI 1177
Query: 158 NREGEWEGRVSELESDVKQLQD---ELERQQIHLREADR----EKSRAVQE------LSE 204
++ G + LE + + L+D +L +Q+ L + ++ E+ + + E ++
Sbjct: 1178 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
Query: 205 QNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE 264
+ ++L + R + QL + L+ D + S N + L+AE L ++ ++
Sbjct: 1238 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297
Query: 265 LE---HRLSATLEENDLLQGTVEE-------------LQDRVL------------ILERQ 296
L+ +L+ E L+G +EE LQ+R L + +RQ
Sbjct: 1298 LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1357
Query: 297 GHDKDLQLHQSQLELQE 313
DK +L + + +L+E
Sbjct: 1358 YIDKLNELRRQKEKLEE 1374
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 74.3 bits (181), Expect = 3e-13
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 56/440 (12%)
Query: 107 EKDLVLAARLGKALLERNQDMSRQYEQMHKELT-------DKLEHLEQEKHELRRRFENR 159
E + + +A+ + ++ Q + + + +E++ +L+ +EQE H + ++
Sbjct: 94 EDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSL 153
Query: 160 EGEWEGRVSELESDVKQLQDELERQQIHLREADREKS---------RAVQEL--SEQNQR 208
E +E ESD+ LQ++L R Q L + +R + RA E+ SE +
Sbjct: 154 RQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGS 213
Query: 209 L-LDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEH 267
L L S E ++L + H L E++R S + +L L++E + +
Sbjct: 214 LGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQ 273
Query: 268 RLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEE 327
LS T E+ + E + +L +Q D + Q+H ++ C++L ++EE
Sbjct: 274 TLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMH-------GMKNKCQELCCELEE 326
Query: 328 LTEERSLQSSAATSTSLLSEIEQSMEAEELE-QEREQLRLQLWEAYCQVRYLCSHLRGND 386
L R +SE EQ EL+ + E LR Q + Q L S L
Sbjct: 327 LQHHRQ-----------VSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRL---- 371
Query: 387 SADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTA 446
D+S DE +E + L+T L +LK + ++V+ L ++
Sbjct: 372 -CTLQKKYDTSQDEQNELLKMQ----LQLQTELRQLKVMKSTLVENQSEKELLCRLQKLH 426
Query: 447 LKEER---DRLRVTSEDKEPKEQLQ------KAIRDRDEAIAKKNAVELELAKCRMDMMS 497
L+ + ++ ++ ++ +E+LQ + +RD + + N + E +M
Sbjct: 427 LQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQ 486
Query: 498 LNSQLLDAIQQKLNLSQQLE 517
L D ++++ ++ QLE
Sbjct: 487 LYQASKDELERQKHMYDQLE 506
Score = 52.8 bits (125), Expect = 9e-07
Identities = 88/364 (24%), Positives = 151/364 (41%), Gaps = 55/364 (15%)
Query: 122 ERNQDMSRQYEQMHKELTDKLEHLE---------QEKHELRRRFENREGEWEGRVSELES 172
+ +QD + +M +L +L L+ Q + EL R + + + E E
Sbjct: 379 DTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEK 438
Query: 173 DVK---QLQDEL---ERQQIHLR----------EADREKSRAVQELSEQNQRLLDQLSRA 216
++ QLQ+EL E + HLR E D E +QE+ + Q D+L R
Sbjct: 439 LLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQ 498
Query: 217 SEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIK--MLSDRKRELEHRLSATLE 274
+ QL + + + +E +S H I + + K L R EL+ + A+ +
Sbjct: 499 KHMYDQLEQDLLLCQLELKELKAS---HPIPEDKGKCANKCDTLLSRLTELQEKYKASQK 555
Query: 275 ENDLLQ-GTVEELQDRVLILERQGHDKDLQLHQSQLELQE--VRLSCRQLQVKVEELTEE 331
E LQ E L+D+ + E QG ++ +LH+ L L + + L ++L K+E+L E
Sbjct: 556 EMGQLQMEQCELLEDQRRMQEEQGQLQE-ELHRLTLPLPKSGLLLKSQELLTKLEDLCEL 614
Query: 332 RSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSA 391
+ L L + + + E+LE E R + E++ Q L D + A
Sbjct: 615 QLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFK--ESHFQ-----EVLENPDDSKLA 667
Query: 392 VSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEER 451
S+ + ++ S+ L E + +Q + D + LL E L EER
Sbjct: 668 KSSKCNRNKQSK--------------LLMEQMQALQVMYDAGQAKQELLQQEQGRLLEER 713
Query: 452 DRLR 455
RL+
Sbjct: 714 KRLQ 717
Score = 48.5 bits (114), Expect = 2e-05
Identities = 74/364 (20%), Positives = 148/364 (40%), Gaps = 44/364 (12%)
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
++E E +++ E +K +V LS R L E R +Q+ A E+ RE
Sbjct: 19 EEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETREL 78
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQG 297
+ L+ L + ++ S ++ E+ ++ LQG + L++ + +LE
Sbjct: 79 AGQHEDDSLELQGLLEDERLASAQQAEV------FTKQIQQLQGELRSLREEISLLE--- 129
Query: 298 HDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEEL 357
H+K+ +L + + EL + + L+ E+ E +S A+ L ++ E E++
Sbjct: 130 HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEH--ESDIASLQEDLCRMQN--ELEDM 185
Query: 358 EQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRT 417
E+ R +++ ++ S G+ + E E
Sbjct: 186 ERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYH----------- 234
Query: 418 ALNELKRLIQSIVDGMEPTVTLLSVEMTALKEER----DRLRVTSEDKEPKEQ------- 466
LNE R +Q + + L E T ER L +TS + + E
Sbjct: 235 FLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDP 294
Query: 467 ----LQKAIRDRDEAI-AKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQD 521
L++ +RD +E + KN + EL C ++ + + Q+ + Q++ L ++L+ Q+
Sbjct: 295 EMQLLRQQLRDAEEQMHGMKNKCQ-ELC-CELEELQHHRQVSEEEQRR--LQRELKCAQN 350
Query: 522 DMHR 525
++ R
Sbjct: 351 EVLR 354
Score = 35.8 bits (81), Expect = 0.11
Identities = 38/196 (19%), Positives = 93/196 (47%), Gaps = 28/196 (14%)
Query: 195 KSRAVQEL----SEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLES 250
K +AVQ + E++ +L +Q+ + ++ L ++ A +F+E + + ++
Sbjct: 859 KLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP-QN 917
Query: 251 LQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRV----------------LILE 294
+ EIK L + REL+ + A+++E L E+L+ ++ ++ E
Sbjct: 918 DKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKE 977
Query: 295 RQGH--DKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQ---SSAATSTSLLSEIE 349
+G +K++ + + +++++V C +L +SL+ A+ L +
Sbjct: 978 ARGKNANKNMNKNANGVKMKKVTKPCS--DTSESDLETRKSLEVVLYYKASQRKLDGLAK 1035
Query: 350 QSMEAEELEQEREQLR 365
+ + EE+E+E++Q++
Sbjct: 1036 EEEKKEEMEEEKKQVK 1051
Score = 33.9 bits (76), Expect = 0.42
Identities = 87/458 (18%), Positives = 182/458 (39%), Gaps = 72/458 (15%)
Query: 120 LLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQD 179
LL R ++ +Y+ KE+ +L+ + E E +RR + +G+ + + L + +
Sbjct: 539 LLSRLTELQEKYKASQKEM-GQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGL 597
Query: 180 ELERQQIHLREADR-EKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALRED-FRE- 236
L+ Q++ + D E Q + E+ ++L+ + + ++ ++ +E F+E
Sbjct: 598 LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEV 657
Query: 237 ----------KNSSTN---QHIIRLESLQA------------------EIKMLSDRKREL 265
K+S N Q + +E +QA + ++L +RKR L
Sbjct: 658 LENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR-L 716
Query: 266 EHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKV 325
+ L LEE LLQ ++ + LE G + ++ +CR+
Sbjct: 717 QADLQLCLEEMQLLQVQSPSIK---MSLESYGKSYGSMVPSNE--------NCRKTYDTT 765
Query: 326 EELTEE--RSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLR 383
+ E +S S+ +S S L + S A E ++YC +
Sbjct: 766 VDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE----------AYGKSYCTTSNSSITYK 815
Query: 384 GNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVE 443
+ + S+ T SS T P R +K LI+ + ++ + E
Sbjct: 816 KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIK--LQAVQAMYQISQEE 873
Query: 444 MTALKEERDRLRVTSED-KEPKEQLQKAIRDRDEAIAKKNAV-----ELELAKCRMDMMS 497
+ L+E+ ++L +D KE + ++ ++ E + K A E++ + ++ +
Sbjct: 874 HSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQ 933
Query: 498 LNSQLLDAIQQKL-----NLSQQLEAWQDDMHRVIDRQ 530
L Q Q +L L QL+ Q+++ ++ +++
Sbjct: 934 LQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKR 971
Score = 32.0 bits (71), Expect = 1.6
Identities = 47/206 (22%), Positives = 88/206 (42%), Gaps = 31/206 (15%)
Query: 264 ELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQ------SQLELQEVRLS 317
E E L A EE + + EE+++ +++ G L +++ ++ EL+E+R
Sbjct: 5 EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQ 64
Query: 318 CRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYC-QVR 376
QL V EL E R L + S+E + L ++ Q E + Q++
Sbjct: 65 VLQL---VAELEETRELAG---------QHEDDSLELQGLLEDERLASAQQAEVFTKQIQ 112
Query: 377 YLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPT 436
L LR ++ + S+ E + S K++ L+ + IQS+ E +
Sbjct: 113 QLQGELR-------SLREEISLLEHEKESELKEI-----EQELHLAQAEIQSLRQAAEDS 160
Query: 437 VTLLSVEMTALKEERDRLRVTSEDKE 462
T ++ +L+E+ R++ ED E
Sbjct: 161 ATEHESDIASLQEDLCRMQNELEDME 186
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 73.9 bits (180), Expect = 4e-13
Identities = 95/477 (19%), Positives = 203/477 (42%), Gaps = 74/477 (15%)
Query: 122 ERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGR----VSELESDVKQL 177
+ Q M +++Q+ +++ ++ HL+QE LR N + E + +++L D +L
Sbjct: 399 QETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARL 458
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVE---RQLSMQVHALREDF 234
+EL + L++ + +K A Q ++ +L + R EV+ R+ + + A ++D
Sbjct: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
Query: 235 REK-----------NSSTNQHIIRLESLQAEIKML--SDRKR-----ELEHRLSATLEEN 276
+ K +S ++ + L+ + L S++KR L+ ++ LE+N
Sbjct: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN 578
Query: 277 DLLQGTVEELQDRVL------ILERQGH----DKDLQLHQSQLELQEVRLSCRQLQVKVE 326
+ L+ +++ ++ +L + H +KD Q+ Q++ L R +L K E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER---DRLTSKEE 635
Query: 327 ELTEERSLQSSAATSTSLLSEI--EQSMEAEELEQEREQL-----RLQLWEAYCQVRYLC 379
EL + +++ L + EQ+ A ELE+ ++ + +++L E Q
Sbjct: 636 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ----- 690
Query: 380 SHLRGNDSADSAVSTDSSMDESSETSSAKD-VPAGSLRTALNELKRLIQSIVDGMEPTVT 438
H N + + D + SE + V + + ++++ IQ + ++
Sbjct: 691 -HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 439 LLSV----------EMTALKEERDRLRVTSEDKEPK-----------EQLQKAIRDRDEA 477
LL E+ A++ E L +D + K E+L+K I ++D
Sbjct: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGK 809
Query: 478 I-AKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMD 533
I + + +E EL K ++ + +Q+ NL + E + M V++ + D
Sbjct: 810 IKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD 866
Score = 61.2 bits (147), Expect = 2e-09
Identities = 78/393 (19%), Positives = 166/393 (42%), Gaps = 54/393 (13%)
Query: 120 LLERNQDMSRQYEQMHKE---------LTDKLEHLEQEKHELRRRFENREGEWEGRVSEL 170
+LE+N+ + Q +Q H + L ++L + EK + ++ E+ R++
Sbjct: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
Query: 171 ESDVKQLQDE---LERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQV 227
E ++K +Q+ L+ + L+ E++ A EL + Q + + + +E QL ++
Sbjct: 634 EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEI 693
Query: 228 HALREDFR---EKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVE 284
E+F+ ++N + + +L++L +E +++ ++ ++E D TVE
Sbjct: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 285 ELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSL 344
EL + LI Q+ + EL +R L +V++L +++ Q S A+
Sbjct: 749 ELLETGLI----------QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE 798
Query: 345 LSE-----------IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVS 393
L + +E+ +EAE L+ ++ +QL +V+ L + L+G + + +
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQL-SITSKVQELQNLLKGKEEQMNTMK 857
Query: 394 TDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSI----------VDGMEPTVTLLSVE 443
E ++ K + L+ LK +Q + E +L +
Sbjct: 858 AVLEEKEKDLANTGKWLQ--DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK 915
Query: 444 MTALKEERDRLRVTSEDKEPKEQLQKAIRDRDE 476
LK L+ D K QL + ++D ++
Sbjct: 916 ENELKRLEAMLKERESDLSSKTQLLQDVQDENK 948
Score = 55.1 bits (131), Expect = 2e-07
Identities = 89/453 (19%), Positives = 179/453 (39%), Gaps = 104/453 (22%)
Query: 101 SVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENRE 160
+V+ +KEKDL A GK L QD+ + E + + + +H +E
Sbjct: 858 AVLEEKEKDL---ANTGKWL----QDLQEENESLKAHVQEVAQH------------NLKE 898
Query: 161 GEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVE 220
+ ELE +K+ ++EL+R + L+E + +LS + Q L D +
Sbjct: 899 ASSASQFEELEIVLKEKENELKRLEAMLKERE-------SDLSSKTQLLQD----VQDEN 947
Query: 221 RQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ 280
+ Q+ L++ ++ SS H + +K++S+R++E +S E D L+
Sbjct: 948 KLFKSQIEQLKQQNYQQASSFPPH-------EELLKVISEREKE----ISGLWNELDSLK 996
Query: 281 GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC-RQLQVKVEELTEERSLQSSAA 339
VE + K+ L + E E S + LQ KV + ++ER
Sbjct: 997 DAVEHQR-----------KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER------- 1038
Query: 340 TSTSLLSEIEQSMEAEELEQEREQLRL-------------QLWEAYCQVRYLCSHLRGND 386
+Q +EA ELE + +L + + + C + G
Sbjct: 1039 ---------QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKEC--MAGTS 1087
Query: 387 SADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSI--------------VDG 432
++ + + E+ E + + ++ L E + ++Q + VD
Sbjct: 1088 GSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1147
Query: 433 MEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCR 492
T+ + T+ ++E +RLR SE+K+ ++ R+R+ + E+E +
Sbjct: 1148 SHKTIKQMQSSFTSSEQELERLR--SENKD----IENLRREREHLEMELEKAEMERSTYV 1201
Query: 493 MDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHR 525
++ L +QL + + + + + D+H+
Sbjct: 1202 TEVRELKAQLNETLTKLRTEQNERQKVAGDLHK 1234
Score = 50.4 bits (119), Expect = 4e-06
Identities = 84/400 (21%), Positives = 177/400 (44%), Gaps = 45/400 (11%)
Query: 96 DPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQY-EQMHKELTDKLEHLEQEKHELRR 154
+ +L I K ++ + KAL Q + EQ +K++ +++E QEK E +
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
Query: 155 RFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLS 214
E LE+ + Q+ + E L E S +E+ + + DQ+S
Sbjct: 746 TVEEL----------LETGLIQVATKEEE----LNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 215 RASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLE 274
AS VE +L +H +D + K+ E L+AE+ ++++++ ++ +++ ++
Sbjct: 792 FASLVE-ELKKVIH--EKDGKIKSVE--------ELLEAELLKVANKEKTVQLSITSKVQ 840
Query: 275 E-NDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERS 333
E +LL+G E++ +LE +K+ L + LQ+++ L+ V+E+ +
Sbjct: 841 ELQNLLKGKEEQMNTMKAVLE----EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 896
Query: 334 LQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRG-NDSADSAV 392
++S+A S E+E + +E E E ++L L E + L+ D
Sbjct: 897 KEASSA---SQFEELE--IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 951
Query: 393 STDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSI---VDGMEPTVTLLSVEMTALKE 449
S + + + ++ P L ++E ++ I + +D ++ V + L+E
Sbjct: 952 SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLRE 1011
Query: 450 ERDRL--RVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELE 487
+ + S +K ++++ K ++R + + AVELE
Sbjct: 1012 KNWEAMEALASTEKMLQDKVNKTSKERQQQV---EAVELE 1048
Score = 48.9 bits (115), Expect = 1e-05
Identities = 72/387 (18%), Positives = 172/387 (44%), Gaps = 55/387 (14%)
Query: 171 ESDVKQLQDELERQQIHLREAD------------REKSRAVQELSEQNQRLLDQLSRASE 218
+S K+L+ E +++ ++ D E V L E++ + D L ++S+
Sbjct: 265 KSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSK 324
Query: 219 VERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDL 278
E L+ +H L+E + L +++ + DR ++L + E +++
Sbjct: 325 GE--LTTLIHQLQEKDK-----------LLAAVKEDAAATKDRCKQLTQEMMTEKERSNV 371
Query: 279 LQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCR----QLQVKVEELTEERSL 334
+ + ++DR+ LE++ + ++H S E Q++++ + Q++ ++ L +E +
Sbjct: 372 V---ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
Query: 335 QSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST 394
A ++T+ E +QS E +L Q+ +L +L E +++ ++ ++ +A
Sbjct: 429 LRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ--EEVQKKNAEQAATQL 486
Query: 395 DSSMDESSETSSAKDVPAGSLRTALNE-LKRLIQSIVDGMEPTVTLLSVEMTALKEERDR 453
+ E +E + RTA +E ++ +QS E V L ++T + +
Sbjct: 487 KVQLQE-AERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
Query: 454 LRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQ---KL 510
L +++L + + + + K+ ++++++ D++ N L IQQ ++
Sbjct: 546 L---------EQRLMQLMESEQKRVNKEESLQMQV----QDILEQNEALKAQIQQFHSQI 592
Query: 511 NLSQQLEAWQDDMHRVI---DRQLMDT 534
+++H+VI D+Q+ T
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQT 619
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/185 (21%), Positives = 87/185 (47%), Gaps = 17/185 (9%)
Query: 151 ELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLL 210
+L+R E E +W+ +V E +KQ+Q + L E R +++ ++ L + + L
Sbjct: 1129 KLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRREREHLE 1187
Query: 211 DQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLS 270
+L +A E+ER + + RE + N+ + +L + Q E + ++ + + L
Sbjct: 1188 MELEKA-EMERSTYV------TEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1240
Query: 271 ATLEENDLLQGTVEELQDRVLILERQGHDKD---LQLHQSQLELQEVRLSCRQLQVKVEE 327
+ G +++ + E + +K+ + L+Q+ +LQ++ LQ ++
Sbjct: 1241 LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL------LQAVNQQ 1294
Query: 328 LTEER 332
LT+E+
Sbjct: 1295 LTKEK 1299
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.9 bits (180), Expect = 4e-13
Identities = 105/489 (21%), Positives = 195/489 (39%), Gaps = 71/489 (14%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + QK L L + L+ ++ + E+M L K + LE+ HE+ R E
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 160 EGEWEGRVSELESDVKQ---LQDELERQQIHLREADREKSRAVQELSEQNQRLL---DQL 213
E + +E + +Q L+++LE ++ ++ EK A ++ + +L DQ
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 214 SRASEVERQLSMQVHALREDFREKNSST-------NQHIIRLESLQAEIKMLSDRKRELE 266
++ S+ + L ++ L + E+ N+H + L+ +K ++ELE
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 267 -------------HRLSATLE------------ENDLLQGTVEELQDRVL--------IL 293
H A L+ + + LQ + L D + I
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 294 ERQGHDKDLQ--LHQSQLELQEVRLSCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQ 350
E +GH DLQ L + + R L ++E L TE S AT L ++ EQ
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 351 SMEA--EELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAK 408
+ + L++E Q+ E + L + + +++D++ +T +
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 409 DVP-AGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQL 467
+ AG LR L + K+ ++ +E V E+ + + +R R DK K Q
Sbjct: 1233 NADLAGELR-VLGQAKQEVEHKKKKLEAQVQ----ELQSKCSDGERARAELNDKVHKLQ- 1286
Query: 468 QKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA-------IQQKLNLSQQLEAWQ 520
+ + N E + K D+ SL+SQL D +QKLN+S +L +
Sbjct: 1287 ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 521 DDMHRVIDR 529
++ + + D+
Sbjct: 1343 EERNSLQDQ 1351
Score = 65.9 bits (159), Expect = 1e-10
Identities = 103/469 (21%), Positives = 183/469 (39%), Gaps = 89/469 (18%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHEL---RRRFENREGEWEGRVS------ 168
KA L++N+ + E+ + +L +L L Q K E+ +++ E + E + + S
Sbjct: 1219 KANLDKNK---QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 169 -ELESDVKQLQDELER----------------------------QQIHLREADREK---S 196
EL V +LQ+E+E Q L+E R+K S
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 197 RAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIK 256
+++L E+ L DQL E ++ L + L + +E+L+ K
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 257 MLSDRKRELEHRLSATLEENDLLQGT----VEELQDRVLILERQ----GHDKDLQLHQSQ 308
L + D L+ T +EL D V+ L+ Q + + Q Q
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 309 LELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA-EELEQEREQLRLQ 367
L +E +S + + E R ++ A SL +E+++EA EELE+ + L+ +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKA---LSLARALEEALEAKEELERTNKMLKAE 1512
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ 427
+ D S ++ E ++ A + ++T L EL+ +Q
Sbjct: 1513 M----------------EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 428 SIVDGMEPTVTLLSVEMTALKE--ERDRLRVTSEDKEPKEQLQKAI-----------RDR 474
+ D L V M ALK ERD +++E + QLQ+ + + R
Sbjct: 1557 ATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
A A K +E +L + S +AI+Q L Q++ +Q ++
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Score = 63.9 bits (154), Expect = 4e-10
Identities = 78/374 (20%), Positives = 160/374 (42%), Gaps = 32/374 (8%)
Query: 169 ELESDVKQLQDELERQQI---HLREADREKSRAVQE---LSEQNQRLLDQLSRASEVERQ 222
E+++ +LQ ERQQ L+E +++ S+ +E L EQ Q + + A E+ +
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 223 LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ-- 280
L+ + L E E + + R + LQAE K ++ + +LE +L LQ
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 281 -----GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQ 335
+++L+D +L+++ Q + + + + ++ + + + K + LT+ ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 336 SSAATSTSLLSEIEQSMEAEE-LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST 394
S++SE+E ++ EE QE E+L+ +L + L+ A+ +
Sbjct: 1033 E------SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQL 1085
Query: 395 DSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERD-- 452
+E + D AL +++ L I D E + + A K++RD
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 453 ----RLRVTSEDKEPKEQLQKAIRDR--DEAIAKKNAVELELAKCRMDMMSLNSQLLDAI 506
L+ ED Q+ +R + E K A++ E + + + A+
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 507 QQKLNLSQQLEAWQ 520
++ L++QLE ++
Sbjct: 1206 EE---LTEQLEQFK 1216
Score = 63.5 bits (153), Expect = 5e-10
Identities = 82/414 (19%), Positives = 176/414 (42%), Gaps = 34/414 (8%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
Q + +E+ K + L++ K E +++ EN E E + S+L + LQ++L+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTK-ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ + R + E + L + +R E E ++++ Q+ L E E+ +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A+IK L D ++ + + +E LL+ + +L + E + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 300 --KDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI-----EQSM 352
K H+S + EVRL ++ + + E +R L+ A+ ++++ E M
Sbjct: 1025 LTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 353 EAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPA 412
+ + E+E + +L + Q +R + S + D + ++ + K
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---- 1139
Query: 413 GSLRTALNELKRLIQSIVDGMEPTVTLLSV------EMTALKEERDRLRVTSEDKEPKEQ 466
R EL+ L + D ++ T T + E+T LK+ D S + + +E
Sbjct: 1140 -QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEM 1197
Query: 467 LQK---AIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
QK A+ + E + + + L K + + N+ L ++ Q++E
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Score = 60.8 bits (146), Expect = 3e-09
Identities = 96/452 (21%), Positives = 182/452 (40%), Gaps = 86/452 (19%)
Query: 100 LSVIRQKEKDL---VLAARLGKALLERN-QDMSRQYEQ--------------MHKELTDK 141
LS ++K +D V A GK ++ +++++QYE+ + +EL D
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 142 LEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREAD--------- 192
+ L+ ++ +L E ++ +++ ++E ++ + DE +R + RE +
Sbjct: 1433 VVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 193 -REKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E A +EL N+ L ++ + + VH L + R + + +LE L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 252 QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLEL 311
+ E++ D K LE + A L+G E +DLQ Q E
Sbjct: 1552 EDELQATEDAKLRLEVNMQA-------LKGQFE---------------RDLQARDEQNEE 1589
Query: 312 QEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEA 371
+ +L RQL EL +ER ++ AA + L + ++LE + + EA
Sbjct: 1590 KRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEG-----DLKDLELQADSAIKGREEA 1643
Query: 372 YCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD 431
Q+R L + ++ D +S DE T+ + A SL L +L+ + +
Sbjct: 1644 IKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--- 1698
Query: 432 GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKC 491
ER R + E +E E+L ++ R+ +K +E +A+
Sbjct: 1699 -----------------AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 492 RMD-------MMSLNSQLLDAIQQKLNLSQQL 516
+ M +++ ++ A QQ LS +L
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Score = 59.7 bits (143), Expect = 7e-09
Identities = 78/383 (20%), Positives = 165/383 (43%), Gaps = 62/383 (16%)
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM 225
+V+ E +++ +DEL++ + ++A+ E ++EL +++ +L ++ + E + Q
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQE-QLQAET 900
Query: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEE 285
+++A E+ R +RL + + E++ E+ H + A LEE + ++
Sbjct: 901 ELYAEAEEMR----------VRLAAKKQELE-------EILHEMEARLEEEE---DRGQQ 940
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLL 345
LQ + +Q D + QL + + Q+++L + K+++L +E + S
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-- 998
Query: 346 SEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETS 405
E + LE+ L L E + + L ++S S + +E S
Sbjct: 999 ------KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--- 1049
Query: 406 SAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKE 465
R L +LKR ++ + L ++ LK + + +E
Sbjct: 1050 ----------RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---------KEE 1090
Query: 466 QLQKAIRDRDEAIAKKNAV-----ELE--LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEA 518
+LQ A+ D+ IA+KN ELE ++ + D+ S + A +QK +L ++LEA
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 519 WQDDMHRVIDRQLMDTHLKERSQ 541
+ ++ +D L+ + +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE 1173
Score = 56.6 bits (135), Expect = 6e-08
Identities = 71/305 (23%), Positives = 132/305 (43%), Gaps = 43/305 (14%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
+Q E+ + + + E +L A K LE N M Q ++L + E E+++ +L+
Sbjct: 1539 TQMEEMKTQLEELEDELQ-ATEDAKLRLEVN--MQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 154 RRFENREGEWEGRVSE----------LESDVKQLQDELERQQIHLREADREKSRAVQELS 203
R+ E E E + LE D+K L+ + + I RE ++ R +Q
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLRKLQAQM 1654
Query: 204 EQNQRLLDQLSRASEVE------------RQLSMQVHALREDFREKNSSTNQHIIRLESL 251
+ QR L+ +RAS E + L + L+ED + Q + E L
Sbjct: 1655 KDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 252 QAEI-------KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQL 304
E+ L D KR LE R++ EE + QG +E + DRV +Q +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 305 -------HQSQLELQEVRLSCRQLQVKVEEL--TEERSLQSSAATSTSLLSEIEQSMEAE 355
+++ Q++ ++L+ K+ E+ + +S+ A + ++++E+ +E E
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 356 ELEQE 360
E++
Sbjct: 1834 AREKQ 1838
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.9 bits (180), Expect = 4e-13
Identities = 105/489 (21%), Positives = 195/489 (39%), Gaps = 71/489 (14%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + QK L L + L+ ++ + E+M L K + LE+ HE+ R E
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 160 EGEWEGRVSELESDVKQ---LQDELERQQIHLREADREKSRAVQELSEQNQRLL---DQL 213
E + +E + +Q L+++LE ++ ++ EK A ++ + +L DQ
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 214 SRASEVERQLSMQVHALREDFREKNSST-------NQHIIRLESLQAEIKMLSDRKRELE 266
++ S+ + L ++ L + E+ N+H + L+ +K ++ELE
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 267 -------------HRLSATLE------------ENDLLQGTVEELQDRVL--------IL 293
H A L+ + + LQ + L D + I
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 294 ERQGHDKDLQ--LHQSQLELQEVRLSCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQ 350
E +GH DLQ L + + R L ++E L TE S AT L ++ EQ
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 351 SMEA--EELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAK 408
+ + L++E Q+ E + L + + +++D++ +T +
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 409 DVP-AGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQL 467
+ AG LR L + K+ ++ +E V E+ + + +R R DK K Q
Sbjct: 1240 NADLAGELR-VLGQAKQEVEHKKKKLEAQVQ----ELQSKCSDGERARAELNDKVHKLQ- 1293
Query: 468 QKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA-------IQQKLNLSQQLEAWQ 520
+ + N E + K D+ SL+SQL D +QKLN+S +L +
Sbjct: 1294 ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 521 DDMHRVIDR 529
++ + + D+
Sbjct: 1350 EERNSLQDQ 1358
Score = 65.9 bits (159), Expect = 1e-10
Identities = 103/469 (21%), Positives = 183/469 (39%), Gaps = 89/469 (18%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHEL---RRRFENREGEWEGRVS------ 168
KA L++N+ + E+ + +L +L L Q K E+ +++ E + E + + S
Sbjct: 1226 KANLDKNK---QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 169 -ELESDVKQLQDELER----------------------------QQIHLREADREK---S 196
EL V +LQ+E+E Q L+E R+K S
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 197 RAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIK 256
+++L E+ L DQL E ++ L + L + +E+L+ K
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 257 MLSDRKRELEHRLSATLEENDLLQGT----VEELQDRVLILERQ----GHDKDLQLHQSQ 308
L + D L+ T +EL D V+ L+ Q + + Q Q
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 309 LELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA-EELEQEREQLRLQ 367
L +E +S + + E R ++ A SL +E+++EA EELE+ + L+ +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKA---LSLARALEEALEAKEELERTNKMLKAE 1519
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ 427
+ D S ++ E ++ A + ++T L EL+ +Q
Sbjct: 1520 M----------------EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 428 SIVDGMEPTVTLLSVEMTALKE--ERDRLRVTSEDKEPKEQLQKAI-----------RDR 474
+ D L V M ALK ERD +++E + QLQ+ + + R
Sbjct: 1564 ATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
A A K +E +L + S +AI+Q L Q++ +Q ++
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Score = 63.9 bits (154), Expect = 4e-10
Identities = 78/374 (20%), Positives = 160/374 (42%), Gaps = 32/374 (8%)
Query: 169 ELESDVKQLQDELERQQI---HLREADREKSRAVQE---LSEQNQRLLDQLSRASEVERQ 222
E+++ +LQ ERQQ L+E +++ S+ +E L EQ Q + + A E+ +
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 223 LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ-- 280
L+ + L E E + + R + LQAE K ++ + +LE +L LQ
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 281 -----GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQ 335
+++L+D +L+++ Q + + + + ++ + + + K + LT+ ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 336 SSAATSTSLLSEIEQSMEAEE-LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST 394
S++SE+E ++ EE QE E+L+ +L + L+ A+ +
Sbjct: 1040 E------SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQL 1092
Query: 395 DSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERD-- 452
+E + D AL +++ L I D E + + A K++RD
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 453 ----RLRVTSEDKEPKEQLQKAIRDR--DEAIAKKNAVELELAKCRMDMMSLNSQLLDAI 506
L+ ED Q+ +R + E K A++ E + + + A+
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 507 QQKLNLSQQLEAWQ 520
++ L++QLE ++
Sbjct: 1213 EE---LTEQLEQFK 1223
Score = 63.5 bits (153), Expect = 5e-10
Identities = 82/414 (19%), Positives = 176/414 (42%), Gaps = 34/414 (8%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
Q + +E+ K + L++ K E +++ EN E E + S+L + LQ++L+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTK-ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ + R + E + L + +R E E ++++ Q+ L E E+ +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A+IK L D ++ + + +E LL+ + +L + E + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 300 --KDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI-----EQSM 352
K H+S + EVRL ++ + + E +R L+ A+ ++++ E M
Sbjct: 1032 LTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 353 EAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPA 412
+ + E+E + +L + Q +R + S + D + ++ + K
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---- 1146
Query: 413 GSLRTALNELKRLIQSIVDGMEPTVTLLSV------EMTALKEERDRLRVTSEDKEPKEQ 466
R EL+ L + D ++ T T + E+T LK+ D S + + +E
Sbjct: 1147 -QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEM 1204
Query: 467 LQK---AIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
QK A+ + E + + + L K + + N+ L ++ Q++E
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Score = 60.8 bits (146), Expect = 3e-09
Identities = 96/452 (21%), Positives = 182/452 (40%), Gaps = 86/452 (19%)
Query: 100 LSVIRQKEKDL---VLAARLGKALLERN-QDMSRQYEQ--------------MHKELTDK 141
LS ++K +D V A GK ++ +++++QYE+ + +EL D
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 142 LEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREAD--------- 192
+ L+ ++ +L E ++ +++ ++E ++ + DE +R + RE +
Sbjct: 1440 VVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 193 -REKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E A +EL N+ L ++ + + VH L + R + + +LE L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 252 QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLEL 311
+ E++ D K LE + A L+G E +DLQ Q E
Sbjct: 1559 EDELQATEDAKLRLEVNMQA-------LKGQFE---------------RDLQARDEQNEE 1596
Query: 312 QEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEA 371
+ +L RQL EL +ER ++ AA + L + ++LE + + EA
Sbjct: 1597 KRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEG-----DLKDLELQADSAIKGREEA 1650
Query: 372 YCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD 431
Q+R L + ++ D +S DE T+ + A SL L +L+ + +
Sbjct: 1651 IKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--- 1705
Query: 432 GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKC 491
ER R + E +E E+L ++ R+ +K +E +A+
Sbjct: 1706 -----------------AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 492 RMD-------MMSLNSQLLDAIQQKLNLSQQL 516
+ M +++ ++ A QQ LS +L
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Score = 59.7 bits (143), Expect = 7e-09
Identities = 78/383 (20%), Positives = 165/383 (43%), Gaps = 62/383 (16%)
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM 225
+V+ E +++ +DEL++ + ++A+ E ++EL +++ +L ++ + E + Q
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQE-QLQAET 907
Query: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEE 285
+++A E+ R +RL + + E++ E+ H + A LEE + ++
Sbjct: 908 ELYAEAEEMR----------VRLAAKKQELE-------EILHEMEARLEEEE---DRGQQ 947
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLL 345
LQ + +Q D + QL + + Q+++L + K+++L +E + S
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-- 1005
Query: 346 SEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETS 405
E + LE+ L L E + + L ++S S + +E S
Sbjct: 1006 ------KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--- 1056
Query: 406 SAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKE 465
R L +LKR ++ + L ++ LK + + +E
Sbjct: 1057 ----------RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---------KEE 1097
Query: 466 QLQKAIRDRDEAIAKKNAV-----ELE--LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEA 518
+LQ A+ D+ IA+KN ELE ++ + D+ S + A +QK +L ++LEA
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 519 WQDDMHRVIDRQLMDTHLKERSQ 541
+ ++ +D L+ + +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE 1180
Score = 56.6 bits (135), Expect = 6e-08
Identities = 71/305 (23%), Positives = 132/305 (43%), Gaps = 43/305 (14%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
+Q E+ + + + E +L A K LE N M Q ++L + E E+++ +L+
Sbjct: 1546 TQMEEMKTQLEELEDELQ-ATEDAKLRLEVN--MQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 154 RRFENREGEWEGRVSE----------LESDVKQLQDELERQQIHLREADREKSRAVQELS 203
R+ E E E + LE D+K L+ + + I RE ++ R +Q
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLRKLQAQM 1661
Query: 204 EQNQRLLDQLSRASEVE------------RQLSMQVHALREDFREKNSSTNQHIIRLESL 251
+ QR L+ +RAS E + L + L+ED + Q + E L
Sbjct: 1662 KDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 252 QAEI-------KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQL 304
E+ L D KR LE R++ EE + QG +E + DRV +Q +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 305 -------HQSQLELQEVRLSCRQLQVKVEEL--TEERSLQSSAATSTSLLSEIEQSMEAE 355
+++ Q++ ++L+ K+ E+ + +S+ A + ++++E+ +E E
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 356 ELEQE 360
E++
Sbjct: 1841 AREKQ 1845
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.9 bits (180), Expect = 4e-13
Identities = 105/489 (21%), Positives = 195/489 (39%), Gaps = 71/489 (14%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + QK L L + L+ ++ + E+M L K + LE+ HE+ R E
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 160 EGEWEGRVSELESDVKQ---LQDELERQQIHLREADREKSRAVQELSEQNQRLL---DQL 213
E + +E + +Q L+++LE ++ ++ EK A ++ + +L DQ
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 214 SRASEVERQLSMQVHALREDFREKNSST-------NQHIIRLESLQAEIKMLSDRKRELE 266
++ S+ + L ++ L + E+ N+H + L+ +K ++ELE
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 267 -------------HRLSATLE------------ENDLLQGTVEELQDRVL--------IL 293
H A L+ + + LQ + L D + I
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 294 ERQGHDKDLQ--LHQSQLELQEVRLSCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQ 350
E +GH DLQ L + + R L ++E L TE S AT L ++ EQ
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 351 SMEA--EELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAK 408
+ + L++E Q+ E + L + + +++D++ +T +
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 409 DVP-AGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQL 467
+ AG LR L + K+ ++ +E V E+ + + +R R DK K Q
Sbjct: 1240 NADLAGELR-VLGQAKQEVEHKKKKLEAQVQ----ELQSKCSDGERARAELNDKVHKLQ- 1293
Query: 468 QKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA-------IQQKLNLSQQLEAWQ 520
+ + N E + K D+ SL+SQL D +QKLN+S +L +
Sbjct: 1294 ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 521 DDMHRVIDR 529
++ + + D+
Sbjct: 1350 EERNSLQDQ 1358
Score = 65.9 bits (159), Expect = 1e-10
Identities = 103/469 (21%), Positives = 183/469 (39%), Gaps = 89/469 (18%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHEL---RRRFENREGEWEGRVS------ 168
KA L++N+ + E+ + +L +L L Q K E+ +++ E + E + + S
Sbjct: 1226 KANLDKNK---QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 169 -ELESDVKQLQDELER----------------------------QQIHLREADREK---S 196
EL V +LQ+E+E Q L+E R+K S
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 197 RAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIK 256
+++L E+ L DQL E ++ L + L + +E+L+ K
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 257 MLSDRKRELEHRLSATLEENDLLQGT----VEELQDRVLILERQ----GHDKDLQLHQSQ 308
L + D L+ T +EL D V+ L+ Q + + Q Q
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 309 LELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA-EELEQEREQLRLQ 367
L +E +S + + E R ++ A SL +E+++EA EELE+ + L+ +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKA---LSLARALEEALEAKEELERTNKMLKAE 1519
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ 427
+ D S ++ E ++ A + ++T L EL+ +Q
Sbjct: 1520 M----------------EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 428 SIVDGMEPTVTLLSVEMTALKE--ERDRLRVTSEDKEPKEQLQKAI-----------RDR 474
+ D L V M ALK ERD +++E + QLQ+ + + R
Sbjct: 1564 ATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
A A K +E +L + S +AI+Q L Q++ +Q ++
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Score = 63.9 bits (154), Expect = 4e-10
Identities = 78/374 (20%), Positives = 160/374 (42%), Gaps = 32/374 (8%)
Query: 169 ELESDVKQLQDELERQQI---HLREADREKSRAVQE---LSEQNQRLLDQLSRASEVERQ 222
E+++ +LQ ERQQ L+E +++ S+ +E L EQ Q + + A E+ +
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 223 LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ-- 280
L+ + L E E + + R + LQAE K ++ + +LE +L LQ
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 281 -----GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQ 335
+++L+D +L+++ Q + + + + ++ + + + K + LT+ ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 336 SSAATSTSLLSEIEQSMEAEE-LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST 394
S++SE+E ++ EE QE E+L+ +L + L+ A+ +
Sbjct: 1040 E------SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQL 1092
Query: 395 DSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERD-- 452
+E + D AL +++ L I D E + + A K++RD
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 453 ----RLRVTSEDKEPKEQLQKAIRDR--DEAIAKKNAVELELAKCRMDMMSLNSQLLDAI 506
L+ ED Q+ +R + E K A++ E + + + A+
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 507 QQKLNLSQQLEAWQ 520
++ L++QLE ++
Sbjct: 1213 EE---LTEQLEQFK 1223
Score = 63.5 bits (153), Expect = 5e-10
Identities = 82/414 (19%), Positives = 176/414 (42%), Gaps = 34/414 (8%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
Q + +E+ K + L++ K E +++ EN E E + S+L + LQ++L+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTK-ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ + R + E + L + +R E E ++++ Q+ L E E+ +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A+IK L D ++ + + +E LL+ + +L + E + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 300 --KDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI-----EQSM 352
K H+S + EVRL ++ + + E +R L+ A+ ++++ E M
Sbjct: 1032 LTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 353 EAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPA 412
+ + E+E + +L + Q +R + S + D + ++ + K
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---- 1146
Query: 413 GSLRTALNELKRLIQSIVDGMEPTVTLLSV------EMTALKEERDRLRVTSEDKEPKEQ 466
R EL+ L + D ++ T T + E+T LK+ D S + + +E
Sbjct: 1147 -QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEM 1204
Query: 467 LQK---AIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
QK A+ + E + + + L K + + N+ L ++ Q++E
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Score = 60.8 bits (146), Expect = 3e-09
Identities = 96/452 (21%), Positives = 182/452 (40%), Gaps = 86/452 (19%)
Query: 100 LSVIRQKEKDL---VLAARLGKALLERN-QDMSRQYEQ--------------MHKELTDK 141
LS ++K +D V A GK ++ +++++QYE+ + +EL D
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 142 LEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREAD--------- 192
+ L+ ++ +L E ++ +++ ++E ++ + DE +R + RE +
Sbjct: 1440 VVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 193 -REKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E A +EL N+ L ++ + + VH L + R + + +LE L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 252 QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLEL 311
+ E++ D K LE + A L+G E +DLQ Q E
Sbjct: 1559 EDELQATEDAKLRLEVNMQA-------LKGQFE---------------RDLQARDEQNEE 1596
Query: 312 QEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEA 371
+ +L RQL EL +ER ++ AA + L + ++LE + + EA
Sbjct: 1597 KRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEG-----DLKDLELQADSAIKGREEA 1650
Query: 372 YCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD 431
Q+R L + ++ D +S DE T+ + A SL L +L+ + +
Sbjct: 1651 IKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--- 1705
Query: 432 GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKC 491
ER R + E +E E+L ++ R+ +K +E +A+
Sbjct: 1706 -----------------AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 492 RMD-------MMSLNSQLLDAIQQKLNLSQQL 516
+ M +++ ++ A QQ LS +L
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Score = 59.7 bits (143), Expect = 7e-09
Identities = 78/383 (20%), Positives = 165/383 (43%), Gaps = 62/383 (16%)
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM 225
+V+ E +++ +DEL++ + ++A+ E ++EL +++ +L ++ + E + Q
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQE-QLQAET 907
Query: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEE 285
+++A E+ R +RL + + E++ E+ H + A LEE + ++
Sbjct: 908 ELYAEAEEMR----------VRLAAKKQELE-------EILHEMEARLEEEE---DRGQQ 947
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLL 345
LQ + +Q D + QL + + Q+++L + K+++L +E + S
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-- 1005
Query: 346 SEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETS 405
E + LE+ L L E + + L ++S S + +E S
Sbjct: 1006 ------KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--- 1056
Query: 406 SAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKE 465
R L +LKR ++ + L ++ LK + + +E
Sbjct: 1057 ----------RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---------KEE 1097
Query: 466 QLQKAIRDRDEAIAKKNAV-----ELE--LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEA 518
+LQ A+ D+ IA+KN ELE ++ + D+ S + A +QK +L ++LEA
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 519 WQDDMHRVIDRQLMDTHLKERSQ 541
+ ++ +D L+ + +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE 1180
Score = 56.6 bits (135), Expect = 6e-08
Identities = 71/305 (23%), Positives = 132/305 (43%), Gaps = 43/305 (14%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
+Q E+ + + + E +L A K LE N M Q ++L + E E+++ +L+
Sbjct: 1546 TQMEEMKTQLEELEDELQ-ATEDAKLRLEVN--MQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 154 RRFENREGEWEGRVSE----------LESDVKQLQDELERQQIHLREADREKSRAVQELS 203
R+ E E E + LE D+K L+ + + I RE ++ R +Q
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLRKLQAQM 1661
Query: 204 EQNQRLLDQLSRASEVE------------RQLSMQVHALREDFREKNSSTNQHIIRLESL 251
+ QR L+ +RAS E + L + L+ED + Q + E L
Sbjct: 1662 KDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 252 QAEI-------KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQL 304
E+ L D KR LE R++ EE + QG +E + DRV +Q +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 305 -------HQSQLELQEVRLSCRQLQVKVEEL--TEERSLQSSAATSTSLLSEIEQSMEAE 355
+++ Q++ ++L+ K+ E+ + +S+ A + ++++E+ +E E
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 356 ELEQE 360
E++
Sbjct: 1841 AREKQ 1845
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 4e-13
Identities = 105/489 (21%), Positives = 195/489 (39%), Gaps = 71/489 (14%)
Query: 100 LSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR 159
L + QK L L + L+ ++ + E+M L K + LE+ HE+ R E
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 160 EGEWEGRVSELESDVKQ---LQDELERQQIHLREADREKSRAVQELSEQNQRLL---DQL 213
E + +E + +Q L+++LE ++ ++ EK A ++ + +L DQ
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 214 SRASEVERQLSMQVHALREDFREKNSST-------NQHIIRLESLQAEIKMLSDRKRELE 266
++ S+ + L ++ L + E+ N+H + L+ +K ++ELE
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 267 -------------HRLSATLE------------ENDLLQGTVEELQDRVL--------IL 293
H A L+ + + LQ + L D + I
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 294 ERQGHDKDLQ--LHQSQLELQEVRLSCRQLQVKVEEL-TEERSLQSSAATSTSLLSEIEQ 350
E +GH DLQ L + + R L ++E L TE S AT L ++ EQ
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 351 SMEA--EELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAK 408
+ + L++E Q+ E + L + + +++D++ +T +
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 409 DVP-AGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQL 467
+ AG LR L + K+ ++ +E V E+ + + +R R DK K Q
Sbjct: 1233 NADLAGELR-VLGQAKQEVEHKKKKLEAQVQ----ELQSKCSDGERARAELNDKVHKLQ- 1286
Query: 468 QKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDA-------IQQKLNLSQQLEAWQ 520
+ + N E + K D+ SL+SQL D +QKLN+S +L +
Sbjct: 1287 ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 521 DDMHRVIDR 529
++ + + D+
Sbjct: 1343 EERNSLQDQ 1351
Score = 65.9 bits (159), Expect = 1e-10
Identities = 103/469 (21%), Positives = 183/469 (39%), Gaps = 89/469 (18%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHEL---RRRFENREGEWEGRVS------ 168
KA L++N+ + E+ + +L +L L Q K E+ +++ E + E + + S
Sbjct: 1219 KANLDKNK---QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 169 -ELESDVKQLQDELER----------------------------QQIHLREADREK---S 196
EL V +LQ+E+E Q L+E R+K S
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 197 RAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIK 256
+++L E+ L DQL E ++ L + L + +E+L+ K
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 257 MLSDRKRELEHRLSATLEENDLLQGT----VEELQDRVLILERQ----GHDKDLQLHQSQ 308
L + D L+ T +EL D V+ L+ Q + + Q Q
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 309 LELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA-EELEQEREQLRLQ 367
L +E +S + + E R ++ A SL +E+++EA EELE+ + L+ +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKA---LSLARALEEALEAKEELERTNKMLKAE 1512
Query: 368 LWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQ 427
+ D S ++ E ++ A + ++T L EL+ +Q
Sbjct: 1513 M----------------EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 428 SIVDGMEPTVTLLSVEMTALKE--ERDRLRVTSEDKEPKEQLQKAI-----------RDR 474
+ D L V M ALK ERD +++E + QLQ+ + + R
Sbjct: 1557 ATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 475 DEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDM 523
A A K +E +L + S +AI+Q L Q++ +Q ++
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Score = 63.9 bits (154), Expect = 4e-10
Identities = 78/374 (20%), Positives = 160/374 (42%), Gaps = 32/374 (8%)
Query: 169 ELESDVKQLQDELERQQI---HLREADREKSRAVQE---LSEQNQRLLDQLSRASEVERQ 222
E+++ +LQ ERQQ L+E +++ S+ +E L EQ Q + + A E+ +
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 223 LSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQ-- 280
L+ + L E E + + R + LQAE K ++ + +LE +L LQ
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 281 -----GTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQ 335
+++L+D +L+++ Q + + + + ++ + + + K + LT+ ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 336 SSAATSTSLLSEIEQSMEAEE-LEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVST 394
S++SE+E ++ EE QE E+L+ +L + L+ A+ +
Sbjct: 1033 E------SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQL 1085
Query: 395 DSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERD-- 452
+E + D AL +++ L I D E + + A K++RD
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 453 ----RLRVTSEDKEPKEQLQKAIRDR--DEAIAKKNAVELELAKCRMDMMSLNSQLLDAI 506
L+ ED Q+ +R + E K A++ E + + + A+
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 507 QQKLNLSQQLEAWQ 520
++ L++QLE ++
Sbjct: 1206 EE---LTEQLEQFK 1216
Score = 63.5 bits (153), Expect = 5e-10
Identities = 82/414 (19%), Positives = 176/414 (42%), Gaps = 34/414 (8%)
Query: 130 QYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLR 189
Q + +E+ K + L++ K E +++ EN E E + S+L + LQ++L+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTK-ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 190 EADREKSRAVQELSEQNQRLLDQLSRASEVE----------RQLSMQVHALREDFREKNS 239
EA+ + R + E + L + +R E E ++++ Q+ L E E+ +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 240 STNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHD 299
+ + + + +A+IK L D ++ + + +E LL+ + +L + E + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 300 --KDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEI-----EQSM 352
K H+S + EVRL ++ + + E +R L+ A+ ++++ E M
Sbjct: 1025 LTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 353 EAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPA 412
+ + E+E + +L + Q +R + S + D + ++ + K
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---- 1139
Query: 413 GSLRTALNELKRLIQSIVDGMEPTVTLLSV------EMTALKEERDRLRVTSEDKEPKEQ 466
R EL+ L + D ++ T T + E+T LK+ D S + + +E
Sbjct: 1140 -QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEM 1197
Query: 467 LQK---AIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
QK A+ + E + + + L K + + N+ L ++ Q++E
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Score = 60.8 bits (146), Expect = 3e-09
Identities = 96/452 (21%), Positives = 182/452 (40%), Gaps = 86/452 (19%)
Query: 100 LSVIRQKEKDL---VLAARLGKALLERN-QDMSRQYEQ--------------MHKELTDK 141
LS ++K +D V A GK ++ +++++QYE+ + +EL D
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 142 LEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREAD--------- 192
+ L+ ++ +L E ++ +++ ++E ++ + DE +R + RE +
Sbjct: 1433 VVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 193 -REKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E A +EL N+ L ++ + + VH L + R + + +LE L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 252 QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLEL 311
+ E++ D K LE + A L+G E +DLQ Q E
Sbjct: 1552 EDELQATEDAKLRLEVNMQA-------LKGQFE---------------RDLQARDEQNEE 1589
Query: 312 QEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEA 371
+ +L RQL EL +ER ++ AA + L + ++LE + + EA
Sbjct: 1590 KRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEG-----DLKDLELQADSAIKGREEA 1643
Query: 372 YCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVD 431
Q+R L + ++ D +S DE T+ + A SL L +L+ + +
Sbjct: 1644 IKQLRKLQAQMK--DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--- 1698
Query: 432 GMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKC 491
ER R + E +E E+L ++ R+ +K +E +A+
Sbjct: 1699 -----------------AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 492 RMD-------MMSLNSQLLDAIQQKLNLSQQL 516
+ M +++ ++ A QQ LS +L
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Score = 59.7 bits (143), Expect = 7e-09
Identities = 78/383 (20%), Positives = 165/383 (43%), Gaps = 62/383 (16%)
Query: 166 RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSM 225
+V+ E +++ +DEL++ + ++A+ E ++EL +++ +L ++ + E + Q
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQE-QLQAET 900
Query: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEE 285
+++A E+ R +RL + + E++ E+ H + A LEE + ++
Sbjct: 901 ELYAEAEEMR----------VRLAAKKQELE-------EILHEMEARLEEEE---DRGQQ 940
Query: 286 LQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLL 345
LQ + +Q D + QL + + Q+++L + K+++L +E + S
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-- 998
Query: 346 SEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETS 405
E + LE+ L L E + + L ++S S + +E S
Sbjct: 999 ------KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--- 1049
Query: 406 SAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKE 465
R L +LKR ++ + L ++ LK + + +E
Sbjct: 1050 ----------RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---------KEE 1090
Query: 466 QLQKAIRDRDEAIAKKNAV-----ELE--LAKCRMDMMSLNSQLLDAIQQKLNLSQQLEA 518
+LQ A+ D+ IA+KN ELE ++ + D+ S + A +QK +L ++LEA
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 519 WQDDMHRVIDRQLMDTHLKERSQ 541
+ ++ +D L+ + +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE 1173
Score = 56.6 bits (135), Expect = 6e-08
Identities = 71/305 (23%), Positives = 132/305 (43%), Gaps = 43/305 (14%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELR 153
+Q E+ + + + E +L A K LE N M Q ++L + E E+++ +L+
Sbjct: 1539 TQMEEMKTQLEELEDELQ-ATEDAKLRLEVN--MQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 154 RRFENREGEWEGRVSE----------LESDVKQLQDELERQQIHLREADREKSRAVQELS 203
R+ E E E + LE D+K L+ + + I RE ++ R +Q
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLRKLQAQM 1654
Query: 204 EQNQRLLDQLSRASEVE------------RQLSMQVHALREDFREKNSSTNQHIIRLESL 251
+ QR L+ +RAS E + L + L+ED + Q + E L
Sbjct: 1655 KDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 252 QAEI-------KMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQL 304
E+ L D KR LE R++ EE + QG +E + DRV +Q +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 305 -------HQSQLELQEVRLSCRQLQVKVEEL--TEERSLQSSAATSTSLLSEIEQSMEAE 355
+++ Q++ ++L+ K+ E+ + +S+ A + ++++E+ +E E
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 356 ELEQE 360
E++
Sbjct: 1834 AREKQ 1838
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 73.2 bits (178), Expect = 6e-13
Identities = 101/438 (23%), Positives = 184/438 (42%), Gaps = 58/438 (13%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENRE---GEWEGRVSELESDV 174
K + ER +D E+M+ ELT K LE E EL+R ++ E + E E+ V
Sbjct: 920 KEMNERLEDE----EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV 975
Query: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234
K L +E+ + + +EK + L E +Q+ LD L + L+ L +
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEK----KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 235 REKNSSTNQHIIRLESLQAEIKMLSDR-KRELEHRLSATLEENDLLQGTVEELQDRVLIL 293
+ S Q + +++M +R KR+LE L T E L+ ++L +R+
Sbjct: 1032 DDLEGSLEQ--------EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 294 ERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSA-ATSTSLLSEIEQSM 352
+ + + + ++ Q +++ ++LQ ++EEL EE + +A A L S++ + +
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 353 E--AEELEQ-----------------EREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVS 393
E +E LE+ E +++R L EA Q + LR ADS
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR-KKHADSVAE 1202
Query: 394 TDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDR 453
+D L +E K + + ME + + + D+
Sbjct: 1203 LGEQIDNLQRVKQ-------KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 454 LRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLS 513
+ +E + E+ Q+++ D AK EL++ + +L SQL + KL +
Sbjct: 1256 M---NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQL---TRGKLTYT 1309
Query: 514 QQLEAWQDDMHRVIDRQL 531
QQLE D+ R ++ ++
Sbjct: 1310 QQLE----DLKRQLEEEV 1323
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/440 (19%), Positives = 174/440 (39%), Gaps = 57/440 (12%)
Query: 105 QKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE 164
Q E++ A L + L + N ++++ + + + E LE+ K +L +R + E E
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 165 G---RVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVER 221
+ S LE +LQ+E+E + D E+S A ++ QR D++
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMV-----DVERSNAAAAALDKKQRNFDKI-------- 1452
Query: 222 QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQG 281
+ ++ + E S LES Q E + LS +L++ +LE + +
Sbjct: 1453 -----LAEWKQKYEESQSE-------LESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500
Query: 282 TVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELT-----EERSLQS 336
+ LQ+ + L Q +H+ + +++ +LQ +EE EE +
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 1560
Query: 337 SAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDS 396
+ + +EIE+ + E ++E EQ + +HLR DS +++ ++
Sbjct: 1561 AQLEFNQIKAEIERKL--AEKDEEMEQAKR-------------NHLRVVDSLQTSLDAET 1605
Query: 397 -SMDESSETSSAKDVPAGSLRTALNELKRL---IQSIVDGMEPTVTLLSVEMTALKEERD 452
S +E+ + + L+ R+ Q V ++ + +++ D
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1665
Query: 453 RLRVTSEDKEPKEQLQKAIRDRDEAIAK-----KNAVELELAKCRMDMMSLNSQLLDAIQ 507
L+ E + L +A + A+ + + E EL + + L+SQ I
Sbjct: 1666 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1725
Query: 508 QKLNLSQQLEAWQDDMHRVI 527
QK + L Q ++ +
Sbjct: 1726 QKKKMDADLSQLQTEVEEAV 1745
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/276 (21%), Positives = 122/276 (44%), Gaps = 23/276 (8%)
Query: 95 QDPELLSVIRQKEKDLVLAARLGKALLE-------RNQDMSRQYEQMHK--ELTDKLEHL 145
Q L S+++ + L A R L E RN + + E++ E T++ L
Sbjct: 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Query: 146 -EQEKHELRRRFENREGEWEGRVSE---LESDVKQLQDELERQQIHLREADREKSRAVQE 201
EQE E R + + +++ +++D+ QLQ E+E R A+ + +A+ +
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
Query: 202 LSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDR 261
+ + L + ++ +ER + + +D + + Q I L+ + +++ L R
Sbjct: 1762 AAMMAEELKKEQDTSAHLER-MKKNMEQTIKDLQHRLDEAEQ--IALKGGKKQLQKLEAR 1818
Query: 262 KRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQL 321
RELE+ L A + N + + + R+ L Q + L + Q + +++L +
Sbjct: 1819 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAY 1878
Query: 322 QVKVEELTEERSLQSSAATSTSLLSEIEQSM-EAEE 356
+ + EE E+ A T+ S +++ + EAEE
Sbjct: 1879 KRQAEEAEEQ------ANTNLSKFRKVQHELDEAEE 1908
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 72.8 bits (177), Expect = 8e-13
Identities = 130/560 (23%), Positives = 236/560 (42%), Gaps = 89/560 (15%)
Query: 29 AAGDAVRSPAAAAALIFPGGSGELELALEEELA--------LLAAGERPSDPGEHPQAEP 80
A G VR+ A AA L LEEE A L A + S+ + E
Sbjct: 1358 ALGSRVRAMEAEAA--------GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1409
Query: 81 GSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTD 140
G+L G + +++ E L+ ++ + V G+ L++ D + + ++L
Sbjct: 1410 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1469
Query: 141 KLEH--------LEQEKHELRRRFENRE-GEWEGRVSELESDVKQLQDELERQQIHLREA 191
LE L +EK + R E RE E EGR E E + + L A
Sbjct: 1470 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-------------EREARALSLTRA 1516
Query: 192 DREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E+ A +EL QN+ L +L + + VH L R + N ++ L
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1576
Query: 252 QAEIKMLSDRKRELEHRLSA--TLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQL 309
+ E+ D K LE + A T E D LQG E ++R L +Q D +++ + +
Sbjct: 1577 EDELTAAEDAKLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERK 1635
Query: 310 ELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE--ELEQEREQLRLQ 367
+ + ++L+ ++EEL ++ +SA + + M+A+ EL +E E+ R
Sbjct: 1636 QRTLAVAARKKLEGELEEL---KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Query: 368 LWEAYCQVRYLCSHLRGNDS-----ADSAVSTDSSMDESSE--TSSAKDVPAGSL-RTAL 419
E + Q R L+G ++ + ++D + ++ + A +V G+L + A+
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1752
Query: 420 NELKRLIQSIVDGMEPTV----------------TLLSVE--MTALKEERDRLRVTSEDK 461
E KR ++ + +E + LL VE T L ER +++ +
Sbjct: 1753 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS---FSAKAE 1809
Query: 462 EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQD 521
++QL++ I++ + +++A A+ +M + +L S+L A +QLE Q+
Sbjct: 1810 SGRQQLERQIQELRGRLGEEDAG--ARARHKMTIAALESKLAQA-------EEQLE--QE 1858
Query: 522 DMHRVIDRQLM---DTHLKE 538
R++ +L+ + LKE
Sbjct: 1859 TRERILSGKLVRRAEKRLKE 1878
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/487 (22%), Positives = 206/487 (42%), Gaps = 73/487 (14%)
Query: 99 LLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEK--------- 149
LL V RQ E VL AR + L++ Q++ +Q + EL ++ LE+E+
Sbjct: 869 LLQVTRQDE---VLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 923
Query: 150 --------HELRRRFENREGEWEGRVSELESDV-------KQLQDELERQQIHLREAD-- 192
E R R R+ E E VSELE+ V +Q+Q E +R Q H++E +
Sbjct: 924 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983
Query: 193 -------REKSRAVQELSEQNQRLLDQ-LSRASEVERQLSMQVHALREDFREKNSSTNQH 244
R+K + + +E + ++ L + +LS + L + E +S +
Sbjct: 984 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1043
Query: 245 IIRLESL-------QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQG 297
+++SL +A I + DR R+ E + L G ELQ++++ +++
Sbjct: 1044 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1103
Query: 298 HDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEEL 357
+ QL + + ELQ L +E L S + + L+E ++ +E+E +
Sbjct: 1104 EELRAQLGRKEEELQAA------LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1157
Query: 358 EQER-EQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDES------SETSSAKDV 410
+ + E+ R L E +R + +A + + + + E + +
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217
Query: 411 PAGSLR----TALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEP 463
LR AL EL ++ G E T L E++ L+ E L+ ++ E
Sbjct: 1218 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277
Query: 464 KE-----QLQKAI-RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
+ QLQ+ R D A+ A E +L + + ++ +++ L +A + + LS++L
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAE-KLQRAQAELENVSGALNEAESKTIRLSKELS 1336
Query: 518 AWQDDMH 524
+ + +H
Sbjct: 1337 STEAQLH 1343
Score = 58.2 bits (139), Expect = 2e-08
Identities = 97/445 (21%), Positives = 177/445 (39%), Gaps = 78/445 (17%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEK-------HELRRRF---ENREGEWEGRVSEL 170
LE Q+ + E+ ++ L +LE L K HEL R E + +V+EL
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1576
Query: 171 ESDVKQLQDELERQQIHLREADREKSRAVQ---ELSEQNQRLLDQLSRASEVER------ 221
E ++ +D R ++ ++ + R +Q E E+ +R L + R +EVER
Sbjct: 1577 EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQ 1636
Query: 222 ---------QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSAT 272
+L ++ L+ + + +L +QA++K L E
Sbjct: 1637 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1696
Query: 273 LEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC-------------- 318
+N + ++ L+ VL L+ + D Q+Q + E+
Sbjct: 1697 FSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK 1756
Query: 319 RQLQVKV----EELTEERS------------LQSSAATSTSLLSEIEQSMEAE----ELE 358
RQL+ ++ EEL EE+S L + +T L +E S +AE +LE
Sbjct: 1757 RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE 1816
Query: 359 QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL-RT 417
++ ++LR +L E R R + + S + +E E + + + +G L R
Sbjct: 1817 RQIQELRGRLGEEDAGAR-----ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR 1871
Query: 418 ALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEA 477
A LK ++ + + L + E+ LRV K+ K QL++A + A
Sbjct: 1872 AEKRLKEVVLQVEEERRVADQLRD------QLEKGNLRV----KQLKRQLEEAEEEASRA 1921
Query: 478 IAKKNAVELELAKCRMDMMSLNSQL 502
A + ++ EL S+N ++
Sbjct: 1922 QAGRRRLQRELEDVTESAESMNREV 1946
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/382 (20%), Positives = 166/382 (43%), Gaps = 29/382 (7%)
Query: 51 ELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
E+E E + LA R GE + + + G G + Q ++ + +++ +++
Sbjct: 1627 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1686
Query: 111 VLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE----GR 166
+ + +N++ ++ + + E+ E L R+ ++R+ + G
Sbjct: 1687 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1746
Query: 167 VS---------ELESDVKQLQDELERQQIH---LREADREKSRAVQELSEQNQRLLDQLS 214
+S +LE + QL++ELE +Q + L + R+ V+ L+ + +
Sbjct: 1747 LSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1806
Query: 215 RASEVERQLSMQVHALREDFREKNSSTN-QHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
+A +QL Q+ LR E+++ +H + + +L+++ L+ + +LE +
Sbjct: 1807 KAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK---LAQAEEQLEQETRERI 1863
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERS 333
L++ + L++ VL +E + D Q + +L++ L +QL+ ++EE EE S
Sbjct: 1864 LSGKLVRRAEKRLKEVVLQVEEERRVAD----QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1919
Query: 334 LQSSAATSTSLLSEIEQSME-AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAV 392
+ A L E+E E AE + +E LR +L + + +R + V
Sbjct: 1920 --RAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG--PLTFTTRTVRQVFRLEEGV 1975
Query: 393 STDSSMDESSETSSAKDVPAGS 414
++D +E+ S P GS
Sbjct: 1976 ASDEEAEEAQPGSGPSPEPEGS 1997
Score = 57.0 bits (136), Expect = 5e-08
Identities = 94/455 (20%), Positives = 186/455 (40%), Gaps = 48/455 (10%)
Query: 129 RQYEQMHKELTDKLEHLEQEKHELRRR---FENREGEWEGRVSEL-------ESDVKQLQ 178
+++E+ L D+ L +E+ L R F ++ E E +V L E+ + ++
Sbjct: 1006 KKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1065
Query: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
D L +++ +E ++ K R E SE +++++Q RA E+ QL + L+
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125
Query: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEH----RLSATLEENDL---LQGTVEELQDRVL 291
L+SL+ L++ + +LE R A + DL L+ EL+D
Sbjct: 1126 DEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--- 1182
Query: 292 ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS 351
L+ ++L+ + Q E+ E++ + + E E ++Q L E+
Sbjct: 1183 TLDSTNAQQELRSKREQ-EVTELKKTLEE-----ETRIHEAAVQELRQRHGQALGEL--- 1233
Query: 352 MEAEELEQER------EQLRLQLWEAYCQVRYLCSHLRGNDSADS------AVSTDSSMD 399
AE+LEQ R E+ RL L ++R S L+ +
Sbjct: 1234 --AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1291
Query: 400 ESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSE 459
+ + A+ A L+ A EL+ + ++ + T+ L + + D + E
Sbjct: 1292 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1351
Query: 460 DKEPKEQLQKAIRDRD-EAIAKKNAVELELA---KCRMDMMSLNSQLLDAIQQKLNLSQQ 515
+ K L +R + EA + +E E A + ++ + +QL + +++ +
Sbjct: 1352 ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA 1411
Query: 516 LEAWQDDMHRVI-DRQLMDTHLKERSQPAAALCRG 549
LEA ++ R + + + L E+++ L RG
Sbjct: 1412 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1446
Score = 52.0 bits (123), Expect = 1e-06
Identities = 107/489 (21%), Positives = 184/489 (37%), Gaps = 104/489 (21%)
Query: 52 LELALEEELALLAAGERP-SDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
LEL L+E GER ++ E Q L +G ++ + K +
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG------------ALNEAESKTI 1329
Query: 111 VLAARLG--KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVS 168
L+ L +A L Q++ ++ + L ++ +E E LR + E E
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1389
Query: 169 ELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVH 228
EL++ QL + RQ+ E++ A L E R+ + +
Sbjct: 1390 ELQTAQAQLSEWRRRQE--------EEAGA--------------LEAGEEARRRAAREAE 1427
Query: 229 ALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRL-SATLEENDLLQGTVEELQ 287
AL + EK + ++ L +R L+ L AT++ +E+ +
Sbjct: 1428 ALTQRLAEKTETVDR--------------LERGRRRLQQELDDATMD--------LEQQR 1465
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSE 347
V LE++ D QL +E R ++ + E R ++ A + T L E
Sbjct: 1466 QLVSTLEKKQRKFD------QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1519
Query: 348 IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
+++ EELE++ LR +L EA S S+ E
Sbjct: 1520 EQEA--REELERQNRALRAEL-EAL---------------LSSKDDVGKSVHELERACRV 1561
Query: 408 KDVPAGSLRTALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEPK 464
+ A LR + EL+ + + D +E TV L + ERD +E +
Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ-----HERDLQGRDEAGEERR 1616
Query: 465 EQLQKAIRD----RDE-------AIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLS 513
QL K +RD RDE A+A + +E EL + + M S +A++Q +
Sbjct: 1617 RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1676
Query: 514 QQL-EAWQD 521
Q+ E W++
Sbjct: 1677 AQMKELWRE 1685
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 72.8 bits (177), Expect = 8e-13
Identities = 130/560 (23%), Positives = 236/560 (42%), Gaps = 89/560 (15%)
Query: 29 AAGDAVRSPAAAAALIFPGGSGELELALEEELA--------LLAAGERPSDPGEHPQAEP 80
A G VR+ A AA L LEEE A L A + S+ + E
Sbjct: 1350 ALGSRVRAMEAEAA--------GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1401
Query: 81 GSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTD 140
G+L G + +++ E L+ ++ + V G+ L++ D + + ++L
Sbjct: 1402 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1461
Query: 141 KLEH--------LEQEKHELRRRFENRE-GEWEGRVSELESDVKQLQDELERQQIHLREA 191
LE L +EK + R E RE E EGR E E + + L A
Sbjct: 1462 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-------------EREARALSLTRA 1508
Query: 192 DREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E+ A +EL QN+ L +L + + VH L R + N ++ L
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1568
Query: 252 QAEIKMLSDRKRELEHRLSA--TLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQL 309
+ E+ D K LE + A T E D LQG E ++R L +Q D +++ + +
Sbjct: 1569 EDELTAAEDAKLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERK 1627
Query: 310 ELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE--ELEQEREQLRLQ 367
+ + ++L+ ++EEL ++ +SA + + M+A+ EL +E E+ R
Sbjct: 1628 QRTLAVAARKKLEGELEEL---KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Query: 368 LWEAYCQVRYLCSHLRGNDS-----ADSAVSTDSSMDESSE--TSSAKDVPAGSL-RTAL 419
E + Q R L+G ++ + ++D + ++ + A +V G+L + A+
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1744
Query: 420 NELKRLIQSIVDGMEPTV----------------TLLSVE--MTALKEERDRLRVTSEDK 461
E KR ++ + +E + LL VE T L ER +++ +
Sbjct: 1745 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS---FSAKAE 1801
Query: 462 EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQD 521
++QL++ I++ + +++A A+ +M + +L S+L A +QLE Q+
Sbjct: 1802 SGRQQLERQIQELRGRLGEEDAG--ARARHKMTIAALESKLAQA-------EEQLE--QE 1850
Query: 522 DMHRVIDRQLM---DTHLKE 538
R++ +L+ + LKE
Sbjct: 1851 TRERILSGKLVRRAEKRLKE 1870
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/487 (22%), Positives = 206/487 (42%), Gaps = 73/487 (14%)
Query: 99 LLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEK--------- 149
LL V RQ E VL AR + L++ Q++ +Q + EL ++ LE+E+
Sbjct: 861 LLQVTRQDE---VLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 915
Query: 150 --------HELRRRFENREGEWEGRVSELESDV-------KQLQDELERQQIHLREAD-- 192
E R R R+ E E VSELE+ V +Q+Q E +R Q H++E +
Sbjct: 916 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975
Query: 193 -------REKSRAVQELSEQNQRLLDQ-LSRASEVERQLSMQVHALREDFREKNSSTNQH 244
R+K + + +E + ++ L + +LS + L + E +S +
Sbjct: 976 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1035
Query: 245 IIRLESL-------QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQG 297
+++SL +A I + DR R+ E + L G ELQ++++ +++
Sbjct: 1036 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1095
Query: 298 HDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEEL 357
+ QL + + ELQ L +E L S + + L+E ++ +E+E +
Sbjct: 1096 EELRAQLGRKEEELQAA------LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1149
Query: 358 EQER-EQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDES------SETSSAKDV 410
+ + E+ R L E +R + +A + + + + E + +
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209
Query: 411 PAGSLR----TALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEP 463
LR AL EL ++ G E T L E++ L+ E L+ ++ E
Sbjct: 1210 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269
Query: 464 KE-----QLQKAI-RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
+ QLQ+ R D A+ A E +L + + ++ +++ L +A + + LS++L
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAE-KLQRAQAELENVSGALNEAESKTIRLSKELS 1328
Query: 518 AWQDDMH 524
+ + +H
Sbjct: 1329 STEAQLH 1335
Score = 58.2 bits (139), Expect = 2e-08
Identities = 97/445 (21%), Positives = 177/445 (39%), Gaps = 78/445 (17%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEK-------HELRRRF---ENREGEWEGRVSEL 170
LE Q+ + E+ ++ L +LE L K HEL R E + +V+EL
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1568
Query: 171 ESDVKQLQDELERQQIHLREADREKSRAVQ---ELSEQNQRLLDQLSRASEVER------ 221
E ++ +D R ++ ++ + R +Q E E+ +R L + R +EVER
Sbjct: 1569 EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQ 1628
Query: 222 ---------QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSAT 272
+L ++ L+ + + +L +QA++K L E
Sbjct: 1629 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1688
Query: 273 LEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC-------------- 318
+N + ++ L+ VL L+ + D Q+Q + E+
Sbjct: 1689 FSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK 1748
Query: 319 RQLQVKV----EELTEERS------------LQSSAATSTSLLSEIEQSMEAE----ELE 358
RQL+ ++ EEL EE+S L + +T L +E S +AE +LE
Sbjct: 1749 RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE 1808
Query: 359 QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL-RT 417
++ ++LR +L E R R + + S + +E E + + + +G L R
Sbjct: 1809 RQIQELRGRLGEEDAGAR-----ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR 1863
Query: 418 ALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEA 477
A LK ++ + + L + E+ LRV K+ K QL++A + A
Sbjct: 1864 AEKRLKEVVLQVEEERRVADQLRD------QLEKGNLRV----KQLKRQLEEAEEEASRA 1913
Query: 478 IAKKNAVELELAKCRMDMMSLNSQL 502
A + ++ EL S+N ++
Sbjct: 1914 QAGRRRLQRELEDVTESAESMNREV 1938
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/382 (20%), Positives = 166/382 (43%), Gaps = 29/382 (7%)
Query: 51 ELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
E+E E + LA R GE + + + G G + Q ++ + +++ +++
Sbjct: 1619 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1678
Query: 111 VLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE----GR 166
+ + +N++ ++ + + E+ E L R+ ++R+ + G
Sbjct: 1679 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1738
Query: 167 VS---------ELESDVKQLQDELERQQIH---LREADREKSRAVQELSEQNQRLLDQLS 214
+S +LE + QL++ELE +Q + L + R+ V+ L+ + +
Sbjct: 1739 LSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1798
Query: 215 RASEVERQLSMQVHALREDFREKNSSTN-QHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
+A +QL Q+ LR E+++ +H + + +L+++ L+ + +LE +
Sbjct: 1799 KAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK---LAQAEEQLEQETRERI 1855
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERS 333
L++ + L++ VL +E + D Q + +L++ L +QL+ ++EE EE S
Sbjct: 1856 LSGKLVRRAEKRLKEVVLQVEEERRVAD----QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1911
Query: 334 LQSSAATSTSLLSEIEQSME-AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAV 392
+ A L E+E E AE + +E LR +L + + +R + V
Sbjct: 1912 --RAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG--PLTFTTRTVRQVFRLEEGV 1967
Query: 393 STDSSMDESSETSSAKDVPAGS 414
++D +E+ S P GS
Sbjct: 1968 ASDEEAEEAQPGSGPSPEPEGS 1989
Score = 57.0 bits (136), Expect = 5e-08
Identities = 94/455 (20%), Positives = 186/455 (40%), Gaps = 48/455 (10%)
Query: 129 RQYEQMHKELTDKLEHLEQEKHELRRR---FENREGEWEGRVSEL-------ESDVKQLQ 178
+++E+ L D+ L +E+ L R F ++ E E +V L E+ + ++
Sbjct: 998 KKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1057
Query: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
D L +++ +E ++ K R E SE +++++Q RA E+ QL + L+
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117
Query: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEH----RLSATLEENDL---LQGTVEELQDRVL 291
L+SL+ L++ + +LE R A + DL L+ EL+D
Sbjct: 1118 DEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--- 1174
Query: 292 ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS 351
L+ ++L+ + Q E+ E++ + + E E ++Q L E+
Sbjct: 1175 TLDSTNAQQELRSKREQ-EVTELKKTLEE-----ETRIHEAAVQELRQRHGQALGEL--- 1225
Query: 352 MEAEELEQER------EQLRLQLWEAYCQVRYLCSHLRGNDSADS------AVSTDSSMD 399
AE+LEQ R E+ RL L ++R S L+ +
Sbjct: 1226 --AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1283
Query: 400 ESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSE 459
+ + A+ A L+ A EL+ + ++ + T+ L + + D + E
Sbjct: 1284 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1343
Query: 460 DKEPKEQLQKAIRDRD-EAIAKKNAVELELA---KCRMDMMSLNSQLLDAIQQKLNLSQQ 515
+ K L +R + EA + +E E A + ++ + +QL + +++ +
Sbjct: 1344 ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA 1403
Query: 516 LEAWQDDMHRVI-DRQLMDTHLKERSQPAAALCRG 549
LEA ++ R + + + L E+++ L RG
Sbjct: 1404 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1438
Score = 52.0 bits (123), Expect = 1e-06
Identities = 107/489 (21%), Positives = 184/489 (37%), Gaps = 104/489 (21%)
Query: 52 LELALEEELALLAAGERP-SDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
LEL L+E GER ++ E Q L +G ++ + K +
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG------------ALNEAESKTI 1321
Query: 111 VLAARLG--KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVS 168
L+ L +A L Q++ ++ + L ++ +E E LR + E E
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1381
Query: 169 ELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVH 228
EL++ QL + RQ+ E++ A L E R+ + +
Sbjct: 1382 ELQTAQAQLSEWRRRQE--------EEAGA--------------LEAGEEARRRAAREAE 1419
Query: 229 ALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRL-SATLEENDLLQGTVEELQ 287
AL + EK + ++ L +R L+ L AT++ +E+ +
Sbjct: 1420 ALTQRLAEKTETVDR--------------LERGRRRLQQELDDATMD--------LEQQR 1457
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSE 347
V LE++ D QL +E R ++ + E R ++ A + T L E
Sbjct: 1458 QLVSTLEKKQRKFD------QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1511
Query: 348 IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
+++ EELE++ LR +L EA S S+ E
Sbjct: 1512 EQEA--REELERQNRALRAEL-EAL---------------LSSKDDVGKSVHELERACRV 1553
Query: 408 KDVPAGSLRTALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEPK 464
+ A LR + EL+ + + D +E TV L + ERD +E +
Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ-----HERDLQGRDEAGEERR 1608
Query: 465 EQLQKAIRD----RDE-------AIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLS 513
QL K +RD RDE A+A + +E EL + + M S +A++Q +
Sbjct: 1609 RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1668
Query: 514 QQL-EAWQD 521
Q+ E W++
Sbjct: 1669 AQMKELWRE 1677
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 72.8 bits (177), Expect = 8e-13
Identities = 130/560 (23%), Positives = 236/560 (42%), Gaps = 89/560 (15%)
Query: 29 AAGDAVRSPAAAAALIFPGGSGELELALEEELA--------LLAAGERPSDPGEHPQAEP 80
A G VR+ A AA L LEEE A L A + S+ + E
Sbjct: 1391 ALGSRVRAMEAEAA--------GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1442
Query: 81 GSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTD 140
G+L G + +++ E L+ ++ + V G+ L++ D + + ++L
Sbjct: 1443 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1502
Query: 141 KLEH--------LEQEKHELRRRFENRE-GEWEGRVSELESDVKQLQDELERQQIHLREA 191
LE L +EK + R E RE E EGR E E + + L A
Sbjct: 1503 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-------------EREARALSLTRA 1549
Query: 192 DREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
E+ A +EL QN+ L +L + + VH L R + N ++ L
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1609
Query: 252 QAEIKMLSDRKRELEHRLSA--TLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQL 309
+ E+ D K LE + A T E D LQG E ++R L +Q D +++ + +
Sbjct: 1610 EDELTAAEDAKLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERK 1668
Query: 310 ELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAE--ELEQEREQLRLQ 367
+ + ++L+ ++EEL ++ +SA + + M+A+ EL +E E+ R
Sbjct: 1669 QRTLAVAARKKLEGELEEL---KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1725
Query: 368 LWEAYCQVRYLCSHLRGNDS-----ADSAVSTDSSMDESSE--TSSAKDVPAGSL-RTAL 419
E + Q R L+G ++ + ++D + ++ + A +V G+L + A+
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1785
Query: 420 NELKRLIQSIVDGMEPTV----------------TLLSVE--MTALKEERDRLRVTSEDK 461
E KR ++ + +E + LL VE T L ER +++ +
Sbjct: 1786 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS---FSAKAE 1842
Query: 462 EPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQD 521
++QL++ I++ + +++A A+ +M + +L S+L A +QLE Q+
Sbjct: 1843 SGRQQLERQIQELRGRLGEEDAG--ARARHKMTIAALESKLAQA-------EEQLE--QE 1891
Query: 522 DMHRVIDRQLM---DTHLKE 538
R++ +L+ + LKE
Sbjct: 1892 TRERILSGKLVRRAEKRLKE 1911
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/487 (22%), Positives = 206/487 (42%), Gaps = 73/487 (14%)
Query: 99 LLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEK--------- 149
LL V RQ E VL AR + L++ Q++ +Q + EL ++ LE+E+
Sbjct: 902 LLQVTRQDE---VLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 956
Query: 150 --------HELRRRFENREGEWEGRVSELESDV-------KQLQDELERQQIHLREAD-- 192
E R R R+ E E VSELE+ V +Q+Q E +R Q H++E +
Sbjct: 957 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 1016
Query: 193 -------REKSRAVQELSEQNQRLLDQ-LSRASEVERQLSMQVHALREDFREKNSSTNQH 244
R+K + + +E + ++ L + +LS + L + E +S +
Sbjct: 1017 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1076
Query: 245 IIRLESL-------QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQG 297
+++SL +A I + DR R+ E + L G ELQ++++ +++
Sbjct: 1077 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1136
Query: 298 HDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEEL 357
+ QL + + ELQ L +E L S + + L+E ++ +E+E +
Sbjct: 1137 EELRAQLGRKEEELQAA------LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1190
Query: 358 EQER-EQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDES------SETSSAKDV 410
+ + E+ R L E +R + +A + + + + E + +
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250
Query: 411 PAGSLR----TALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEP 463
LR AL EL ++ G E T L E++ L+ E L+ ++ E
Sbjct: 1251 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310
Query: 464 KE-----QLQKAI-RDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
+ QLQ+ R D A+ A E +L + + ++ +++ L +A + + LS++L
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAE-KLQRAQAELENVSGALNEAESKTIRLSKELS 1369
Query: 518 AWQDDMH 524
+ + +H
Sbjct: 1370 STEAQLH 1376
Score = 58.2 bits (139), Expect = 2e-08
Identities = 97/445 (21%), Positives = 177/445 (39%), Gaps = 78/445 (17%)
Query: 121 LERNQDMSRQYEQMHKELTDKLEHLEQEK-------HELRRRF---ENREGEWEGRVSEL 170
LE Q+ + E+ ++ L +LE L K HEL R E + +V+EL
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1609
Query: 171 ESDVKQLQDELERQQIHLREADREKSRAVQ---ELSEQNQRLLDQLSRASEVER------ 221
E ++ +D R ++ ++ + R +Q E E+ +R L + R +EVER
Sbjct: 1610 EDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQ 1669
Query: 222 ---------QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSAT 272
+L ++ L+ + + +L +QA++K L E
Sbjct: 1670 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1729
Query: 273 LEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSC-------------- 318
+N + ++ L+ VL L+ + D Q+Q + E+
Sbjct: 1730 FSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK 1789
Query: 319 RQLQVKV----EELTEERS------------LQSSAATSTSLLSEIEQSMEAE----ELE 358
RQL+ ++ EEL EE+S L + +T L +E S +AE +LE
Sbjct: 1790 RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLE 1849
Query: 359 QEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL-RT 417
++ ++LR +L E R R + + S + +E E + + + +G L R
Sbjct: 1850 RQIQELRGRLGEEDAGAR-----ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR 1904
Query: 418 ALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEA 477
A LK ++ + + L + E+ LRV K+ K QL++A + A
Sbjct: 1905 AEKRLKEVVLQVEEERRVADQLRD------QLEKGNLRV----KQLKRQLEEAEEEASRA 1954
Query: 478 IAKKNAVELELAKCRMDMMSLNSQL 502
A + ++ EL S+N ++
Sbjct: 1955 QAGRRRLQRELEDVTESAESMNREV 1979
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/382 (20%), Positives = 166/382 (43%), Gaps = 29/382 (7%)
Query: 51 ELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
E+E E + LA R GE + + + G G + Q ++ + +++ +++
Sbjct: 1660 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1719
Query: 111 VLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWE----GR 166
+ + +N++ ++ + + E+ E L R+ ++R+ + G
Sbjct: 1720 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1779
Query: 167 VS---------ELESDVKQLQDELERQQIH---LREADREKSRAVQELSEQNQRLLDQLS 214
+S +LE + QL++ELE +Q + L + R+ V+ L+ + +
Sbjct: 1780 LSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1839
Query: 215 RASEVERQLSMQVHALREDFREKNSSTN-QHIIRLESLQAEIKMLSDRKRELEHRLSATL 273
+A +QL Q+ LR E+++ +H + + +L+++ L+ + +LE +
Sbjct: 1840 KAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK---LAQAEEQLEQETRERI 1896
Query: 274 EENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERS 333
L++ + L++ VL +E + D Q + +L++ L +QL+ ++EE EE S
Sbjct: 1897 LSGKLVRRAEKRLKEVVLQVEEERRVAD----QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1952
Query: 334 LQSSAATSTSLLSEIEQSME-AEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAV 392
+ A L E+E E AE + +E LR +L + + +R + V
Sbjct: 1953 --RAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG--PLTFTTRTVRQVFRLEEGV 2008
Query: 393 STDSSMDESSETSSAKDVPAGS 414
++D +E+ S P GS
Sbjct: 2009 ASDEEAEEAQPGSGPSPEPEGS 2030
Score = 57.0 bits (136), Expect = 5e-08
Identities = 94/455 (20%), Positives = 186/455 (40%), Gaps = 48/455 (10%)
Query: 129 RQYEQMHKELTDKLEHLEQEKHELRRR---FENREGEWEGRVSEL-------ESDVKQLQ 178
+++E+ L D+ L +E+ L R F ++ E E +V L E+ + ++
Sbjct: 1039 KKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME 1098
Query: 179 DELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKN 238
D L +++ +E ++ K R E SE +++++Q RA E+ QL + L+
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158
Query: 239 SSTNQHIIRLESLQAEIKMLSDRKRELEH----RLSATLEENDL---LQGTVEELQDRVL 291
L+SL+ L++ + +LE R A + DL L+ EL+D
Sbjct: 1159 DEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--- 1215
Query: 292 ILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQS 351
L+ ++L+ + Q E+ E++ + + E E ++Q L E+
Sbjct: 1216 TLDSTNAQQELRSKREQ-EVTELKKTLEE-----ETRIHEAAVQELRQRHGQALGEL--- 1266
Query: 352 MEAEELEQER------EQLRLQLWEAYCQVRYLCSHLRGNDSADS------AVSTDSSMD 399
AE+LEQ R E+ RL L ++R S L+ +
Sbjct: 1267 --AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1324
Query: 400 ESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSE 459
+ + A+ A L+ A EL+ + ++ + T+ L + + D + E
Sbjct: 1325 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1384
Query: 460 DKEPKEQLQKAIRDRD-EAIAKKNAVELELA---KCRMDMMSLNSQLLDAIQQKLNLSQQ 515
+ K L +R + EA + +E E A + ++ + +QL + +++ +
Sbjct: 1385 ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA 1444
Query: 516 LEAWQDDMHRVI-DRQLMDTHLKERSQPAAALCRG 549
LEA ++ R + + + L E+++ L RG
Sbjct: 1445 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERG 1479
Score = 52.0 bits (123), Expect = 1e-06
Identities = 107/489 (21%), Positives = 184/489 (37%), Gaps = 104/489 (21%)
Query: 52 LELALEEELALLAAGERP-SDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDL 110
LEL L+E GER ++ E Q L +G ++ + K +
Sbjct: 1315 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG------------ALNEAESKTI 1362
Query: 111 VLAARLG--KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVS 168
L+ L +A L Q++ ++ + L ++ +E E LR + E E
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1422
Query: 169 ELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVH 228
EL++ QL + RQ+ E++ A L E R+ + +
Sbjct: 1423 ELQTAQAQLSEWRRRQE--------EEAGA--------------LEAGEEARRRAAREAE 1460
Query: 229 ALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRL-SATLEENDLLQGTVEELQ 287
AL + EK + ++ L +R L+ L AT++ +E+ +
Sbjct: 1461 ALTQRLAEKTETVDR--------------LERGRRRLQQELDDATMD--------LEQQR 1498
Query: 288 DRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSE 347
V LE++ D QL +E R ++ + E R ++ A + T L E
Sbjct: 1499 QLVSTLEKKQRKFD------QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1552
Query: 348 IEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSA 407
+++ EELE++ LR +L EA S S+ E
Sbjct: 1553 EQEA--REELERQNRALRAEL-EAL---------------LSSKDDVGKSVHELERACRV 1594
Query: 408 KDVPAGSLRTALNELKRLIQSIVDG---MEPTVTLLSVEMTALKEERDRLRVTSEDKEPK 464
+ A LR + EL+ + + D +E TV L + ERD +E +
Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ-----HERDLQGRDEAGEERR 1649
Query: 465 EQLQKAIRD----RDE-------AIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLS 513
QL K +RD RDE A+A + +E EL + + M S +A++Q +
Sbjct: 1650 RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQ 1709
Query: 514 QQL-EAWQD 521
Q+ E W++
Sbjct: 1710 AQMKELWRE 1718
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 72.8 bits (177), Expect = 8e-13
Identities = 134/635 (21%), Positives = 256/635 (40%), Gaps = 105/635 (16%)
Query: 6 LGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEELALLAA 65
L L R + A +SA C V + A L EL+ E L L +
Sbjct: 108 LELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTS 167
Query: 66 GERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQ 125
E + G PQ P + +E P Q PE+ V+ + ++ V +L K + +
Sbjct: 168 HEA-TPQGRLPQESPETKSE-------PGQGPEMQEVLLEVQRLRVENQQLSKDYARKAE 219
Query: 126 DMSRQYEQ--------MHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQL 177
++ YE+ M + ++ L ++++ +LR+ F+ +E S L++ V++L
Sbjct: 220 ELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQE-------SALQAQVRKL 272
Query: 178 QDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREK 237
+ +LE H + + Q+L E+ Q L QL A RQ + ++ + EK
Sbjct: 273 EGDLE----HRGRKISDLKKYAQKLKERIQDLDVQLKEA----RQENSELKGTAKKLGEK 324
Query: 238 NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE--- 294
+ ++ E + K EL EENDL G + QD+ + E
Sbjct: 325 LAVAKDRMMLQECRGTQ--QTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPC 382
Query: 295 --------------------RQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSL 334
+Q +++DL+ + Q E ++ L QL ++E+L ++ ++
Sbjct: 383 MKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLK-DQLVKRLEDLVKKHTV 441
Query: 335 QSSAATST------SLLSEIEQSM---------EAEELEQEREQLRLQLWEAYCQVRYLC 379
+ + S+ L E+E + E ++LE+E+ L ++L + +V L
Sbjct: 442 EIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLE 501
Query: 380 SHLRGNDSAD---------------SAVSTDSSMDESSETS----SAKDVPAGSLRTALN 420
++ N + S + T + ETS +D A T+ +
Sbjct: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSD 561
Query: 421 ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSED-KEPKEQLQKAIRDRDEAIA 479
E +R + +G +P L S+ LKE+ +++ ED + K +LQ + +A+
Sbjct: 562 EEERTKVLLKEGSDPQPPLGSL----LKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALE 617
Query: 480 KKNA---VELELAKCRMDM--MSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDR----Q 530
+ + +L+ K D+ L +L + QQ + QLEA R++++ +
Sbjct: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Query: 531 LMDTHLKERSQPAAALCRGHSAGRGDEPSIAEGKR 565
L T + + + + +L H R + ++ E R
Sbjct: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKAR 712
Score = 62.0 bits (149), Expect = 1e-09
Identities = 94/467 (20%), Positives = 196/467 (41%), Gaps = 96/467 (20%)
Query: 94 SQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQ------ 147
+++ LL I+ E L L RL + L + S + E +EL + EH E+
Sbjct: 92 AEEEALLQRIQALESALELQKRLTEEALA--ESASCRLETKERELRVEAEHAERVLTLSR 149
Query: 148 EKHELRRRFENR-------EGEWEGRVSELESDVK-------QLQD---ELERQQIHLRE 190
E EL+ +E R E +GR+ + + K ++Q+ E++R ++ ++
Sbjct: 150 EMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQ 209
Query: 191 ADREKSRAVQELSEQNQRLLDQLSRA----------------SEVERQLSMQVHALREDF 234
++ +R +EL +R + + +A S++ + +Q AL+
Sbjct: 210 LSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQV 269
Query: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294
R+ ++ L+ + L +R ++L+ +L +EN L+GT ++L ++
Sbjct: 270 RKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK----- 324
Query: 295 RQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA 354
L + + ++ LQE R + + +K E ++E + L+ E +EA
Sbjct: 325 -------LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLRE------------ENDLEA 365
Query: 355 EELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGS 414
L +++Q L+ C ++G + + S+ET K
Sbjct: 366 GNLHPQQDQSCLK----------ECPCMKG------GTDMQTKKEASAETEYMKQQYEED 409
Query: 415 LRTALN----ELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKA 470
LR + E K L +V +E V +VE+ + V S + +++LQ+
Sbjct: 410 LRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKS---------VRSSVEAERKKLQRE 460
Query: 471 IRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLE 517
+ + E + KK+ E E+ + + +LN +L +++ + L L + ++
Sbjct: 461 VEAQLEEVRKKS--EKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
Score = 58.5 bits (140), Expect = 2e-08
Identities = 83/389 (21%), Positives = 162/389 (41%), Gaps = 59/389 (15%)
Query: 118 KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQL 177
K LL+ D + KE T K++ LE++ W+ + ++L++ V Q+
Sbjct: 567 KVLLKEGSDPQPPLGSLLKEKTSKIQRLEED--------------WQSQKAKLQAQVSQM 612
Query: 178 QDELERQQIHLRE----------ADREK-SRAVQELSEQNQRLLDQLSRASE-----VER 221
Q LE+ + RE +REK R +QE ++QN + QL + + +E+
Sbjct: 613 QQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEK 672
Query: 222 QLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE--LEHRLSATLEENDLL 279
++ A E ++++S + Q I+ ++ + E++ L ++ R+ E R ++ LL
Sbjct: 673 ARHQELKATEERLKKESSHSLQ--IQHQTHRLELQALEEKARQELQEERERMQAQQALLL 730
Query: 280 QGTVEELQDRVLILERQGHDKDLQLHQSQLEL---QEVRLSCRQLQVKVEELTEERSLQS 336
+ +EL ++ GH KDL+ Q++L Q+ C TEER
Sbjct: 731 ESLRQELSEQQAAC--SGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPG 788
Query: 337 SAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDS 396
A + + S E L +E QL+ + +V + A
Sbjct: 789 QAGSPPGAAG--QGSGEGCGLWEENAQLQDAVRRLRAEVE------QHQQEAQKLRDQRR 840
Query: 397 SMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALK-------E 449
++E+ + A++V T E ++ +Q++V L + AL+ E
Sbjct: 841 FLEETQQAQRAREV-----ETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGE 895
Query: 450 ERDRLRVTSEDKEPKEQLQKAIRDRDEAI 478
+ + ED + +LQ +++R++ I
Sbjct: 896 KPGKGASRPEDLQLIGRLQTRLKEREDII 924
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,263,217
Number of Sequences: 37866
Number of extensions: 1037396
Number of successful extensions: 16594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 471
Number of HSP's successfully gapped in prelim test: 1137
Number of HSP's that attempted gapping in prelim test: 7608
Number of HSP's gapped (non-prelim): 5228
length of query: 573
length of database: 18,247,518
effective HSP length: 108
effective length of query: 465
effective length of database: 14,157,990
effective search space: 6583465350
effective search space used: 6583465350
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.