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Search of human proteins with 118918429
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118918429 NOD3 protein [Homo sapiens]
(1065 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118918429 NOD3 protein [Homo sapiens] 2083 0.0
gi|11545912 nucleotide-binding oligomerization domain containing... 213 8e-55
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 206 7e-53
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 205 2e-52
gi|5174617 nucleotide-binding oligomerization domain containing ... 190 5e-48
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 186 8e-47
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 186 8e-47
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 179 1e-44
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 175 2e-43
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 169 1e-41
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 162 2e-39
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 157 5e-38
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 155 2e-37
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 142 2e-33
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 134 3e-31
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 132 2e-30
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 129 1e-29
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 129 1e-29
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 129 1e-29
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 128 3e-29
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 128 3e-29
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 128 3e-29
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 124 6e-28
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 122 2e-27
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 121 4e-27
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 2083 bits (5396), Expect = 0.0
Identities = 1065/1065 (100%), Positives = 1065/1065 (100%)
Query: 1 MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSND 60
MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSND
Sbjct: 1 MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSND 60
Query: 61 SRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPAR 120
SRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPAR
Sbjct: 61 SRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPAR 120
Query: 121 TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR 180
TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR
Sbjct: 121 TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR 180
Query: 181 DLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPK 240
DLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPK
Sbjct: 181 DLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPK 240
Query: 241 KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ 300
KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ
Sbjct: 241 KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ 300
Query: 301 MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL 360
MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL
Sbjct: 301 MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL 360
Query: 361 CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM 420
CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM
Sbjct: 361 CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM 420
Query: 421 KAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFT 480
KAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFT
Sbjct: 421 KAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFT 480
Query: 481 ESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQ 540
ESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQ
Sbjct: 481 ESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQ 540
Query: 541 AYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAH 600
AYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAH
Sbjct: 541 AYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAH 600
Query: 601 RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSV 660
RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSV
Sbjct: 601 RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSV 660
Query: 661 LSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI 720
LSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI
Sbjct: 661 LSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI 720
Query: 721 NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSL 780
NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSL
Sbjct: 721 NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSL 780
Query: 781 KELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS 840
KELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS
Sbjct: 781 KELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS 840
Query: 841 LRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN 900
LRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN
Sbjct: 841 LRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN 900
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGA 960
FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGA
Sbjct: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGA 960
Query: 961 SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAI 1020
SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAI
Sbjct: 961 SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAI 1020
Query: 1021 CIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
CIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM
Sbjct: 1021 CIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 213 bits (542), Expect = 8e-55
Identities = 220/773 (28%), Positives = 349/773 (45%), Gaps = 65/773 (8%)
Query: 121 TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR 180
T+ L+ LF ++ + +G AG GK+TL++ LWA GQ ++F V P + R
Sbjct: 275 TLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCR 334
Query: 181 DLNTHEKLCADRLIC---SVFPHVGEP---SLAVAVPARALLILDGLDECRTPLDFSNTV 234
L K + R + +P VG+ L + P R LL DG DE + F++
Sbjct: 335 QLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK--FRFTDRE 392
Query: 235 ACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEI 294
P V L+ N+++GNL +TSRP+A + ++GF+E+ I
Sbjct: 393 RHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGI 452
Query: 295 KVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAEL 354
++ L + E + ++ +Q AL+ +C +P F + L G
Sbjct: 453 ELYLRKRHHE-PGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG------ 505
Query: 355 WPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYV 414
P+T ++Y + L + + G + LGRLA GL YV
Sbjct: 506 -SPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYV 564
Query: 415 FYEQDMKAFGV---DLALLQGAPCSCFLQREETL--ASSVAYCFTHLSLQEFVAAAYYY- 468
F Q ++A V D++L FL R + + S+ F H++ Q F AA Y
Sbjct: 565 FSAQQLQAAQVSPDDISL-------GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLAL 617
Query: 469 -----GASRRAIFDLFTESGVSWPRL-------GFLTHFRSAAQRAMQAEDGRLDVFLRF 516
A R +F+ RL S A +AE L + F
Sbjct: 618 SADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAF 677
Query: 517 LSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLR-------PDAAVCARAIN--- 566
L+GLLS LLA ++ + L LR P A A++++
Sbjct: 678 LAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMP 737
Query: 567 ----VLHCLHELQHTELARSVEEAMESGALARLT----GPAHRAALAYLLQ-VSDACAQE 617
++ L+E+Q LAR + G L +LT GP AALA++LQ + A +
Sbjct: 738 GFIWLIRSLYEMQEERLARKAARGLNVGHL-KLTFCSVGPTECAALAFVLQHLRRPVALQ 796
Query: 618 ANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD-PVMELLGSVLSGKDCRIQKISLAEN 676
+ + S+ ++ LLP L C+ L L N D + +L+ L + ++QK++L N
Sbjct: 797 LDYN-SVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCE--QLQKLALFNN 853
Query: 677 QISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRD 736
++++ A ++A+ L ++ +L L N I GA+ LA+ L+ N +L L GN V D
Sbjct: 854 KLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 913
Query: 737 DGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAK 796
+GA+++AEAL +++L L L N+IG +GAQ +A L +N L+EL N + D G
Sbjct: 914 EGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVC 973
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPE 849
+LAE LK N L+ L L +N I+ G AL+ AL N T+L + LR N+ S E
Sbjct: 974 SLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLE 1026
Score = 114 bits (284), Expect = 6e-25
Identities = 94/280 (33%), Positives = 135/280 (48%), Gaps = 3/280 (1%)
Query: 761 SIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISD 820
S+ M +R+A + ++ L + S+G ALA L+ + +L L NS+ D
Sbjct: 745 SLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGD 804
Query: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGAR 880
GV L+ L + L LR+N+IS G + L+ L L N L D A
Sbjct: 805 IGVEQLLPCLGVCKALY---LRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAH 861
Query: 881 AIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVAR 940
++A + + +L L N+I A AQ L + L+ N SL L N +GD+GA A+A
Sbjct: 862 SMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAE 921
Query: 941 ALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKV 1000
AL + +L L L +IG+ GAQ L LA N LE L L N + G +LA LK
Sbjct: 922 ALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKK 981
Query: 1001 NSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGN 1040
NSSL+ L L N + GA + AL N + + L+GN
Sbjct: 982 NSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGN 1021
Score = 114 bits (284), Expect = 6e-25
Identities = 83/248 (33%), Positives = 126/248 (50%), Gaps = 3/248 (1%)
Query: 741 SMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAE 800
++A L R L L NS+G +G +++ L K L N+I D G L E
Sbjct: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV---CKALYLRDNNISDRGICKLIE 837
Query: 801 ALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCA 860
+ L+ L L +N ++D ++ L Q L+L L N I+ GAQ +A L
Sbjct: 838 CALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG 897
Query: 861 NSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSL 920
N++L+ L N + D+GA+A+A A+ ++++L L L N I + AQAL L N L
Sbjct: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
Query: 921 TSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILD 980
L L+EN + D+G C++A LK N++L L L I GA+ L +AL N T+ +
Sbjct: 958 EELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVW 1017
Query: 981 LRGNAIGV 988
LRGN +
Sbjct: 1018 LRGNTFSL 1025
Score = 110 bits (274), Expect = 9e-24
Identities = 86/282 (30%), Positives = 134/282 (47%), Gaps = 3/282 (1%)
Query: 686 LARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEA 745
LAR ++ L L S+GP ALA L+ R +L L N+V D G +
Sbjct: 754 LARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC 813
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVN 805
L L+L+ N+I G ++ + L++L +N + DG A ++A+ L
Sbjct: 814 LG---VCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACR 870
Query: 806 QGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLK 865
Q +L L +N I+ AG L L N +L L N + EGAQA+A AL + +L+
Sbjct: 871 QNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLR 930
Query: 866 NLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDL 925
L L N + GA+A+A+ + +N L L L+ N +Q +L + L+ N SL L L
Sbjct: 931 WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
Query: 926 QENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLG 967
N I GA A+ +AL+ N + ++L+ + LG
Sbjct: 991 SNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLG 1032
Score = 103 bits (256), Expect = 1e-21
Identities = 83/244 (34%), Positives = 118/244 (48%), Gaps = 3/244 (1%)
Query: 685 ALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAE 744
ALA L R +L L NS+G G + L L + + +L L+ N + D G + E
Sbjct: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCK---ALYLRDNNISDRGICKLIE 837
Query: 745 ALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKV 804
L L L N + A MA L ++ L +N I GA+ LAE L+
Sbjct: 838 CALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG 897
Query: 805 NQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTL 864
N L+ L N + D G AL AL +Q+L LSL N+I GAQA+A L N L
Sbjct: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
Query: 865 KNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLD 924
+ L L N L D+G ++A +++N +L L L N I A+AL QAL+ N ++ +
Sbjct: 958 EELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVW 1017
Query: 925 LQEN 928
L+ N
Sbjct: 1018 LRGN 1021
Score = 85.1 bits (209), Expect = 3e-16
Identities = 73/221 (33%), Positives = 107/221 (48%), Gaps = 5/221 (2%)
Query: 839 LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQ 898
L L S+ P A+A L L L N + D G + + +L+L+
Sbjct: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLG---VCKALYLR 823
Query: 899 WNFIQ-AGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVAS 957
N I G + + AL + L L L N + D A ++A+ L AL L
Sbjct: 824 DNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNY 882
Query: 958 IGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMD 1017
I A+GAQVL E L N +L+ L GN +G GA+ALA AL + SLR L+L N++G
Sbjct: 883 ITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSV 942
Query: 1018 GAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNA 1058
GA +A L+ N L+ + L+ NH+ D G ++E +K N+
Sbjct: 943 GAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS 983
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 206 bits (525), Expect = 7e-53
Identities = 243/914 (26%), Positives = 381/914 (41%), Gaps = 102/914 (11%)
Query: 85 HRLASLLLV-EGLTDLQLREHDF-TQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSI 142
HR LLLV E +Q+++ T R GH A + ++ LF P PPR +
Sbjct: 155 HRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVV 214
Query: 143 TIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADR-LICSVFPH 200
G AG+GK+ L + WA G++ + F + + R++N C+ + LI S +P
Sbjct: 215 MQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPE 274
Query: 201 VGEP-SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFP 259
P + VP R L I+DG DE + C +++ P + L+ ++IR L P
Sbjct: 275 PSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLP 334
Query: 260 EVSIWITSRPSASGQIPGGLV-DRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQA 318
E+S+ IT+RP+A ++ L R EI GF+E E K + F + G + + V+
Sbjct: 335 ELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYF-HNAEQAGQVFNYVRD 393
Query: 319 DRALYLMCTVPAFCRLTGMAL------GHLWRSRTGPQDAELWPPRTLCELYSWYFRMAL 372
+ L+ MC VP C + L G L R + RT +Y Y +
Sbjct: 394 NEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTS----------RTTTAVYMLYLLSLM 443
Query: 373 SGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQG 432
+ +PR++ + L LA GL +K +F EQD++ G+D G
Sbjct: 444 -----QPKPGAPRLQPPPN-----QRGLCSLAADGLWNQKILFEEQDLRKHGLD-----G 488
Query: 433 APCSCFLQR---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRL 489
S FL ++ + Y F HLS QEF AA YY + + +G
Sbjct: 489 EDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYY------ILDEGEGGAGPDQDVT 542
Query: 490 GFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAEL 549
LT + +E L + RFL GLL+ + L SL + + + +
Sbjct: 543 RLLTEYAF-------SERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPH-IKMDLLQW 594
Query: 550 LQGCLRPDAAVCAR-AINVLHCLHELQHTE----------------LARSVEEAMESGAL 592
+Q + D + + ++ CL+E+Q E +A +E + S L
Sbjct: 595 IQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCL 654
Query: 593 ARLTGP--AHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLL---------------PQ 635
R H Y D A L Q +++L P
Sbjct: 655 KRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPN 714
Query: 636 LLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS 695
L+ +L L N ++LL L +C++Q + L +IS+ + L+ +L+ N++
Sbjct: 715 LI---ELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKN 771
Query: 696 LTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSM 754
LT +DL GN +G G L + L+ + L + L+ + + MA L +N L
Sbjct: 772 LTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE 831
Query: 755 LHLQKNSIGPMGAQRMADALKQN-RSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDL 813
L L N++ +G + + L+ L+ L + LA L VNQ L LDL
Sbjct: 832 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL 891
Query: 814 QSNSISDAGVAALMGAL----CTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDL 869
N + D GV L L C QTL R S + EG + L AN L+ LDL
Sbjct: 892 SLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV---LQANHNLRELDL 948
Query: 870 TANLLHDQGARAIAVAVRENR-TLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQEN 928
+ N L D G +A ++ L L L + A A + L L +N++LT L L N
Sbjct: 949 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN 1008
Query: 929 AIGDDGACAVARAL 942
A+GD G + + L
Sbjct: 1009 ALGDTGVRLLCKRL 1022
Score = 115 bits (289), Expect = 2e-25
Identities = 106/378 (28%), Positives = 163/378 (43%), Gaps = 10/378 (2%)
Query: 694 RSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLS 753
RS L L G + G + + L L + + D + +A AL +N L
Sbjct: 658 RSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLP-ERTVLLDAYSEHLAAALCTNPNLI 716
Query: 754 MLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLD 812
L L +N++G G + + L+ N L+ L I + L+ AL N+ L +D
Sbjct: 717 ELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMD 776
Query: 813 LQSNSISDAGVAALMGALCTNQTLLSL-SLRENSISPEGAQAIAHALCANSTLKNLDLTA 871
L N + G+ L L Q L + LR+ + Q +A L N L LDLT
Sbjct: 777 LSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTG 836
Query: 872 NLLHDQGARAIAVAVRENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAI 930
N L D G R + +R L +L L+ + A A L L +N+SL LDL N +
Sbjct: 837 NALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNEL 896
Query: 931 GDDGACAVARALKVNTA-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVA 989
GD G + L+ T L L L + +G++ + L L N L LDL N +G
Sbjct: 897 GDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDW 956
Query: 990 GAKALANALKVNSSLRRLNLQENSLGMDGAIC--IATALSGNHRLQHINLQGNHIGDSGA 1047
G LA L+ + + R L +S G+ C + L N L + L N +GD+G
Sbjct: 957 GLWLLAEGLQ-HPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015
Query: 1048 RMISEAIKTNAPTCTVEM 1065
R++ + + + P C + +
Sbjct: 1016 RLLCK--RLSHPGCKLRV 1031
Score = 47.0 bits (110), Expect = 1e-04
Identities = 60/248 (24%), Positives = 99/248 (39%), Gaps = 46/248 (18%)
Query: 533 LLAQG-EHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
LL +G H R Q+ +L + L ++ C +VL L +L + E +
Sbjct: 789 LLCEGLRHPQCRLQMIQLRKCQL--ESGACQEMASVLGTNPHLVELDLTGNALEDLGLRL 846
Query: 592 LAR-LTGPAHRAALAYL--LQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQ 648
L + L P R +L +++ A E +LS++Q + R+L L N+
Sbjct: 847 LCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSL-----------RELDLSLNE 895
Query: 649 FQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGP 708
D + LL L C++Q + L ++ + + L+ L N +L LDL N +G
Sbjct: 896 LGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGD 955
Query: 709 QGAKALADALK-----------------------------INRTLTSLSLQGNTVRDDGA 739
G LA+ L+ IN+TLT L L N + D G
Sbjct: 956 WGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015
Query: 740 RSMAEALA 747
R + + L+
Sbjct: 1016 RLLCKRLS 1023
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 205 bits (521), Expect = 2e-52
Identities = 233/923 (25%), Positives = 398/923 (43%), Gaps = 92/923 (9%)
Query: 124 LDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDL 182
L+ LF + P++ + G AG+GKTTLVR + WA G + + F V L R++
Sbjct: 162 LEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREI 221
Query: 183 NTHEKLCADRLICSVFPHVGEPSLAVAV-PARALLILDGLDECRTPLDFSNTVACTDPKK 241
N ++ +LI +P P + P+ L I+D DE + C D +
Sbjct: 222 NQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQ 281
Query: 242 EIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDR-MTEIRGFNEEEIKVCLEQ 300
E PV L+++++R + PE S+ +T+R + S ++ L + E+ G +E+ + + Q
Sbjct: 282 EHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQ 341
Query: 301 MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTG-PQDAELWPPRT 359
F ED+ + S ++++ L+ MC VP C W + T Q E T
Sbjct: 342 FF-EDKRWAMKVFSSLKSNEMLFSMCQVPLVC----------WAACTCLKQQMEKGGDVT 390
Query: 360 L-CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQ 418
L C+ + F +S SP + A R L ++A G+ YVFY +
Sbjct: 391 LTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRR-----LCQVAAKGIWTMTYVFYRE 445
Query: 419 DMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDL 478
+++ G+ + + S +Q++ + Y FTHL +QEF AA +Y
Sbjct: 446 NLRRLGLTQSDVSSFMDSNIIQKDAEYEN--CYVFTHLHVQEFFAAMFYMLKG------- 496
Query: 479 FTESGVSW----PRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSP-RVNALLAGSL 533
SW P +S Q + +D L FL GLL+ RV L
Sbjct: 497 ------SWEAGNPSCQPFEDLKSLLQ-STSYKDPHLTQMKCFLFGLLNEDRVKQL----- 544
Query: 534 LAQGEHQAYRTQVAELLQGCLRPDAAVCARA---------INVLHCLHELQHTELARSVE 584
+ + +++ ++ L V + + + HCL+E Q
Sbjct: 545 -----ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAM 599
Query: 585 EAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSL--SQGVLQSLLP-------Q 635
A+ + H ++ L+ C + LS+++ + +L++ LP +
Sbjct: 600 RCFPKVAI-NICEKIHLLVSSFCLKHC-RCLRTIRLSVTVVFEKKILKTSLPTNTWDGDR 657
Query: 636 LLYC--------------RKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNK 681
+ +C R+L L + M +L L +C++QK+ L +
Sbjct: 658 ITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD- 716
Query: 682 GAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGAR 740
G + ++ SL+ N++L LDL+G+ IG G K+L +ALK L +L L+ +
Sbjct: 717 GCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCL 776
Query: 741 SMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALA 799
+++ AL +++L L+L N++ G Q + +AL+ + L+ L S + + G + L+
Sbjct: 777 NISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLS 836
Query: 800 EALKVNQGLESLDLQSNSISDAGVAALMGALCTNQ-TLLSLSLRENSISPEGAQAIAHAL 858
AL N+ L L L N + D GV + AL Q TL SL LR + ++ ++ +L
Sbjct: 837 LALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSL 896
Query: 859 CANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLN 917
N +L +LDL +N L D G + + R + L L L + L + N
Sbjct: 897 LHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNN 956
Query: 918 RSLTSLDLQENAIGDDGACAVARALKV-NTALTALYLQVASIGASGAQVLGEALAVNRTL 976
+L SLDL N + DDG + AL+ N + L L+ + + Q L AL N+ L
Sbjct: 957 PNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRL 1016
Query: 977 EILDLRGNAIGVAGAKALANALK 999
++L N +G G L LK
Sbjct: 1017 IKMNLTQNTLGYEGIVKLYKVLK 1039
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/207 (28%), Positives = 99/207 (47%), Gaps = 4/207 (1%)
Query: 852 QAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQAL 910
Q + L N L+ LDL + L + +R N L L L++ G Q +
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGC-QDI 721
Query: 911 GQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVLGEA 969
+L N++L LDL+ + IGD+G ++ ALK L L L+ ++ + A
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
Query: 970 LAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSG 1028
L +++L L+L N + G + L AL+ L RL+L+ L G ++ AL
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 1029 NHRLQHINLQGNHIGDSGARMISEAIK 1055
N RL H+ L N +GD G +++S+A++
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQ 868
Score = 43.5 bits (101), Expect = 0.001
Identities = 33/102 (32%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICI 1022
Q L L N L LDL + + + L + L+ N L++L L+ + DG I
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFP-DGCQDI 721
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
+T+L N L H++L+G+ IGD+G + + EA+K P C ++
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALK--HPECKLQ 761
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/107 (25%), Positives = 52/107 (48%)
Query: 640 RKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSL 699
R L L N QD +++L L +C IQ++ L +++ + L+ +L+ N+ L +
Sbjct: 960 RSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKM 1019
Query: 700 DLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEAL 746
+L N++G +G L LK + + D+ A+ + EA+
Sbjct: 1020 NLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAV 1066
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 190 bits (483), Expect = 5e-48
Identities = 212/782 (27%), Positives = 338/782 (43%), Gaps = 85/782 (10%)
Query: 144 IGVAGMGKTTLVRHFVRLWAHGQVG---KDFSLVLPLTFRDLNTHEKLCADRLICSVFPH 200
+G AG+GK+ L++ LWA G++ K F F ++LC L+ F H
Sbjct: 201 LGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLL---FKH 257
Query: 201 VGEP--------SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNI 252
P + + P AL DGLDE + LD S + P + L+ N+
Sbjct: 258 YCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANL 317
Query: 253 IRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWM 312
+ G L S +T+R ++P + + +RGF+ ++ +MFPE +AL +
Sbjct: 318 LSGKLLKGASKLLTARTGI--EVPRQFLRKKVLLRGFSPSHLRAYARRMFPE-RALQDRL 374
Query: 313 LSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTG-PQDAELWPPRTLCELYSWYFRMA 371
LSQ++A+ L +C+VP FC + H + G PQ + TL +++ +
Sbjct: 375 LSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDC--TMTLTDVFLLVTEVH 432
Query: 372 LS----GEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDL 427
L+ ++ SP + H GR + +LG++A G+ K +VF +++++A G+
Sbjct: 433 LNRMQPSSLVQRNTRSP--VETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQE 490
Query: 428 ALLQGAPCSCFLQREETLA---SSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGV 484
+Q FL+ L +Y F HL+LQ F A + R +L
Sbjct: 491 RDMQLG----FLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
Query: 485 SWPRLGFLTHFRSAAQRAMQAEDG----RLDVFLR---------FLSGLLSPRVNALLAG 531
P G T Q G R D+F FL GLLS LL
Sbjct: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
Query: 532 SLLAQGEHQAYRTQVAEL---LQGCLRPDAAVCARAIN----------VLHCLHELQHTE 578
+ A + + A L L+G L+ V + N +L C++E Q +
Sbjct: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQK 666
Query: 579 LARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLY 638
+ G LA A+ L Y S C+ LS L P+ L
Sbjct: 667 V----------GQLAARGICANYLKLTYCNACSADCSA---LSFVLHH------FPKRL- 706
Query: 639 CRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTS 698
L LD N D + L S R+ + L+ NQI++ G K L+ L + +T
Sbjct: 707 --ALDLDNNNLNDYGVRELQPCFS----RLTVLRLSVNQITDGGVKVLSEELTKYKIVTY 760
Query: 699 LDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758
L L N I GA+ + L + LT L L N + +G + +A A+ +++++S + +
Sbjct: 761 LGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMW 820
Query: 759 KNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N +G GA+ A+AL+ + SL L +SN I G K+LA AL+ N LE L L N +
Sbjct: 821 GNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNEL 880
Query: 819 SDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQG 878
+D +L L NQTL L L +N I+ +G +A AL +N+ + + L NL+ +
Sbjct: 881 NDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEE 940
Query: 879 AR 880
A+
Sbjct: 941 AK 942
Score = 117 bits (292), Expect = 8e-26
Identities = 78/238 (32%), Positives = 120/238 (50%), Gaps = 3/238 (1%)
Query: 698 SLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHL 757
+LDL N++ G + L LT L L N + D G + ++E L + ++ L L
Sbjct: 707 ALDLDNNNLNDYGVRELQPCFS---RLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGL 763
Query: 758 QKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNS 817
N I +GA+ + L + + L L N I G K LA A+K ++ + + + N
Sbjct: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
Query: 818 ISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
+ D G A AL + +L +LSL N IS EG +++A AL N++L+ L LT N L+D+
Sbjct: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE 883
Query: 878 GARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGA 935
A ++A ++ N+TL L L N I A L ALQ N +T + L N I + A
Sbjct: 884 VAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEA 941
Score = 110 bits (275), Expect = 7e-24
Identities = 80/243 (32%), Positives = 126/243 (51%), Gaps = 3/243 (1%)
Query: 810 SLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDL 869
+LDL +N+++D GV L + T+L LS+ N I+ G + ++ L + L L
Sbjct: 707 ALDLDNNNLNDYGVRELQPCF-SRLTVLRLSV--NQITDGGVKVLSEELTKYKIVTYLGL 763
Query: 870 TANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENA 929
N + D GAR + + E + LT L L N I + + L A++ ++S++ + + N
Sbjct: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
Query: 930 IGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVA 989
+GD+GA A A AL+ + +LT L L I G + L AL N +LEIL L N +
Sbjct: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE 883
Query: 990 GAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARM 1049
A++LA LKVN +L+ L L +N + G +A AL N + I L GN I A++
Sbjct: 884 VAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
Query: 1050 ISE 1052
+
Sbjct: 944 YED 946
Score = 110 bits (275), Expect = 7e-24
Identities = 79/246 (32%), Positives = 123/246 (50%), Gaps = 3/246 (1%)
Query: 755 LHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQ 814
L L N++ G + + + L L S N I DGG K L+E L + + L L
Sbjct: 708 LDLDNNNLNDYGVRELQPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
Query: 815 SNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLL 874
+N I+D G + L + L L L +N I+ EG + +A A+ + ++ + + N +
Sbjct: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
Query: 875 HDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDG 934
D+GA+A A A+R + +LT+L L N I ++L +ALQ N SL L L +N + D+
Sbjct: 825 GDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEV 884
Query: 935 ACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKAL 994
A ++A LKVN L L+L I A G L +AL N + + L GN I AK
Sbjct: 885 AESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVY 944
Query: 995 ANALKV 1000
+ ++
Sbjct: 945 EDEKRI 950
Score = 102 bits (254), Expect = 2e-21
Identities = 72/230 (31%), Positives = 117/230 (50%), Gaps = 3/230 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLR 842
L +N++ D G + L L L L N I+D GV L L + + L L
Sbjct: 708 LDLDNNNLNDYGVRELQPCFS---RLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
Query: 843 ENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFI 902
N I+ GA+ + L L +L L N + +G + +A+AV+ +++++ + + N +
Sbjct: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
Query: 903 QAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASG 962
A+A +AL+ + SLT+L L N I +G ++ARAL+ NT+L L+L +
Sbjct: 825 GDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEV 884
Query: 963 AQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQEN 1012
A+ L E L VN+TL+ L L N I G LA+AL+ N+ + + L N
Sbjct: 885 AESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
Score = 87.0 bits (214), Expect = 8e-17
Identities = 51/137 (37%), Positives = 78/137 (56%)
Query: 668 IQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSL 727
I ++ + NQ+ ++GAKA A +L + SLT+L L N I +G K+LA AL+ N +L L
Sbjct: 814 ISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEIL 873
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSS 787
L N + D+ A S+AE L N+TL L L +N I G ++ADAL+ N + E+ +
Sbjct: 874 WLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNG 933
Query: 788 NSIGDGGAKALAEALKV 804
N I AK + ++
Sbjct: 934 NLIKPEEAKVYEDEKRI 950
Score = 63.5 bits (153), Expect = 1e-09
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 3/144 (2%)
Query: 922 SLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDL 981
+LDL N + D G V + LT L L V I G +VL E L + + L L
Sbjct: 707 ALDLDNNNLNDYG---VRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGL 763
Query: 982 RGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNH 1041
N I GA+ + L L L L +N + +G +A A+ + + + + GN
Sbjct: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
Query: 1042 IGDSGARMISEAIKTNAPTCTVEM 1065
+GD GA+ +EA++ + T+ +
Sbjct: 824 VGDEGAKAFAEALRNHPSLTTLSL 847
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 186 bits (473), Expect = 8e-47
Identities = 218/884 (24%), Positives = 359/884 (40%), Gaps = 72/884 (8%)
Query: 86 RLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIG 145
R L L++ Q RE + + T+ P + ++ LF P S P + G
Sbjct: 167 RYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQG 226
Query: 146 VAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEP 204
AG+GKT L R + WA G + +D F + + R+++ + LI S P P
Sbjct: 227 AAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPP 286
Query: 205 -SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSI 263
V P+R L ++DG DE + D CTD +K D L++++IR L PE S+
Sbjct: 287 IHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASL 346
Query: 264 WITSRPSASGQIPGGLVD--RMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
IT+RP A ++ L+D R EI GF+E + K + F D+A S +Q +
Sbjct: 347 LITTRPVALEKLQ-HLLDHPRHVEILGFSEAKRKEYFFKYF-SDEAQARAAFSLIQENEV 404
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+ MC +P C + + G + +G A+ +T +Y ++ L
Sbjct: 405 LFTMCFIPLVCWI--VCTGLKQQMESGKSLAQ--TSKTTTAVYVFFLSSLL--------- 451
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
PR HG + L LA G+ +K +F E D++ G LQ A S FL+
Sbjct: 452 -QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHG-----LQKADVSAFLRM 505
Query: 442 ---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSA 498
++ + Y F H++ QEF AA YY + S + P +
Sbjct: 506 NLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENY 565
Query: 499 AQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDA 558
+ E G L +RFL GL++ + L L + Q + +
Sbjct: 566 G----KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKL 621
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
+ + + +CL+E+Q + + + + T H VS C +
Sbjct: 622 QIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDH--------MVSSFCIENC 673
Query: 619 NLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQI 678
+ SLS G L ++ + + + + ++++ VL L + +
Sbjct: 674 HRVESLSLGFLHNMPKE--------EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHL 725
Query: 679 SNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK-INRTLTSLSLQGNTVRDD 737
++ + L L ++SLT LDL NS+G G + L + L+ + L L + +
Sbjct: 726 TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHE 785
Query: 738 GARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAK 796
++ L+SN+ L L L N++G G + + LK +LK+L S + +
Sbjct: 786 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQ-TLLSLSLRENSISPEGAQAIA 855
LA L + L L + N++ D+GVA L Q L L L + ++ A++
Sbjct: 846 DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 905
Query: 856 HALCANSTLKNLDLTANLLHDQGARAIA-----------VAVRENRTLTSLHLQWNFIQA 904
L N L +L L N L D+G + + V +N LTS H W+
Sbjct: 906 SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS-HCCWD---- 960
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTAL 948
L L ++SL L L N +GD G LK + L
Sbjct: 961 -----LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Score = 70.1 bits (170), Expect = 1e-11
Identities = 59/231 (25%), Positives = 105/231 (45%), Gaps = 5/231 (2%)
Query: 838 SLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLH 896
S L + ++ + + L + +L LDL+ N L D G R + ++ + L
Sbjct: 717 SHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLW 776
Query: 897 LQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQV 955
L + + L N+ L LDL +NA+GD G + LK + L L+L
Sbjct: 777 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 836
Query: 956 ASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSL 1014
+ ++ Q L L+ + +L L + NA+G +G L K +L++L L + L
Sbjct: 837 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 896
Query: 1015 GMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
+++ LS N L H+ L+GN +GD G +++ E + P C +++
Sbjct: 897 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL--HPDCKLQV 945
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 186 bits (473), Expect = 8e-47
Identities = 218/884 (24%), Positives = 359/884 (40%), Gaps = 72/884 (8%)
Query: 86 RLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIG 145
R L L++ Q RE + + T+ P + ++ LF P S P + G
Sbjct: 167 RYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQG 226
Query: 146 VAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEP 204
AG+GKT L R + WA G + +D F + + R+++ + LI S P P
Sbjct: 227 AAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPP 286
Query: 205 -SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSI 263
V P+R L ++DG DE + D CTD +K D L++++IR L PE S+
Sbjct: 287 IHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASL 346
Query: 264 WITSRPSASGQIPGGLVD--RMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
IT+RP A ++ L+D R EI GF+E + K + F D+A S +Q +
Sbjct: 347 LITTRPVALEKLQ-HLLDHPRHVEILGFSEAKRKEYFFKYF-SDEAQARAAFSLIQENEV 404
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+ MC +P C + + G + +G A+ +T +Y ++ L
Sbjct: 405 LFTMCFIPLVCWI--VCTGLKQQMESGKSLAQ--TSKTTTAVYVFFLSSLL--------- 451
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
PR HG + L LA G+ +K +F E D++ G LQ A S FL+
Sbjct: 452 -QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHG-----LQKADVSAFLRM 505
Query: 442 ---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSA 498
++ + Y F H++ QEF AA YY + S + P +
Sbjct: 506 NLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENY 565
Query: 499 AQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDA 558
+ E G L +RFL GL++ + L L + Q + +
Sbjct: 566 G----KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKL 621
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
+ + + +CL+E+Q + + + + T H VS C +
Sbjct: 622 QIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDH--------MVSSFCIENC 673
Query: 619 NLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQI 678
+ SLS G L ++ + + + + ++++ VL L + +
Sbjct: 674 HRVESLSLGFLHNMPKE--------EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHL 725
Query: 679 SNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK-INRTLTSLSLQGNTVRDD 737
++ + L L ++SLT LDL NS+G G + L + L+ + L L + +
Sbjct: 726 TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHE 785
Query: 738 GARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAK 796
++ L+SN+ L L L N++G G + + LK +LK+L S + +
Sbjct: 786 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQ-TLLSLSLRENSISPEGAQAIA 855
LA L + L L + N++ D+GVA L Q L L L + ++ A++
Sbjct: 846 DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 905
Query: 856 HALCANSTLKNLDLTANLLHDQGARAIA-----------VAVRENRTLTSLHLQWNFIQA 904
L N L +L L N L D+G + + V +N LTS H W+
Sbjct: 906 SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS-HCCWD---- 960
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTAL 948
L L ++SL L L N +GD G LK + L
Sbjct: 961 -----LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Score = 70.1 bits (170), Expect = 1e-11
Identities = 59/231 (25%), Positives = 105/231 (45%), Gaps = 5/231 (2%)
Query: 838 SLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLH 896
S L + ++ + + L + +L LDL+ N L D G R + ++ + L
Sbjct: 717 SHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLW 776
Query: 897 LQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQV 955
L + + L N+ L LDL +NA+GD G + LK + L L+L
Sbjct: 777 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 836
Query: 956 ASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSL 1014
+ ++ Q L L+ + +L L + NA+G +G L K +L++L L + L
Sbjct: 837 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 896
Query: 1015 GMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
+++ LS N L H+ L+GN +GD G +++ E + P C +++
Sbjct: 897 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL--HPDCKLQV 945
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 179 bits (454), Expect = 1e-44
Identities = 239/947 (25%), Positives = 391/947 (41%), Gaps = 89/947 (9%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICS 196
PR + G +G+GK+ L R V WA G + + FS V L R++ ++ I
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
Query: 197 VFPHVGEPSLAV-AVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRG 255
+P P + + P R L I+DG D+ + L+ ++T C D ++ P LI +++R
Sbjct: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLN-NDTKLCKDWAEKQPPFTLIRSLLRK 397
Query: 256 NLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFN-EEEIKVCLEQMFPEDQALLGWML 313
L PE + +T R + ++ +V R +RG + E+ I + LE+ E Q G L
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQG--L 455
Query: 314 SQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALS 373
+ +R L C VPA L +AL + G A +TL L++ + L+
Sbjct: 456 RAIMNNRELLDQCQVPAVGSLICVALQ--LQDVVGESVAPF--NQTLTGLHAAFVFHQLT 511
Query: 374 GEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGA 433
G + + +E+ R ++ R+A G+ +K VF D+ G+ + L+
Sbjct: 512 PRGVVRRCLN--LEE-----RVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRAL 564
Query: 434 PCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRR---AIFDLFTESGVSWPRLG 490
L + Y F HLSLQ+F AA YY A+ L+ E
Sbjct: 565 FHMNILLPDSHCEEY--YTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEK-------- 614
Query: 491 FLTHFRSAAQRAMQAEDGRLDV----FLRFLSGLLSPRVNA---LLAGSLLAQGEHQAYR 543
+R+M+ + + RFL GL+S V +L G + G Q
Sbjct: 615 --------TKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLL 666
Query: 544 TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAA 603
V+ L Q +P+A ++ HCL E Q E R + + L P ++
Sbjct: 667 HWVSLLGQ---QPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWL-----PINQ-- 716
Query: 604 LAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSG 663
NL L S LQ Y RK+R+D V + S
Sbjct: 717 ---------------NLDLIASSFCLQ----HCPYLRKIRVD-------VKGIFPRDESA 750
Query: 664 KDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRT 723
+ C + + + + + + + L + L LDL + + + K L L+
Sbjct: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
Query: 724 LTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKE- 782
+ N G + + + +NR L L+L + + +ALK + L E
Sbjct: 811 KIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLES 870
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLS-LSL 841
L + +++ L + L+SL L N ++D GV L AL +Q L L L
Sbjct: 871 LRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLIL 930
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR-ENRTLTSLHLQWN 900
+ I+ G Q++A AL +N +L +L L+ N L ++G + ++R + +L L L
Sbjct: 931 EDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQC 990
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTA-LTALYLQVASIG 959
+ L AL N LT L L N + D+G + ++ + L L L +
Sbjct: 991 HLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLT 1050
Query: 960 ASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDG 1018
A+ + L ++ +R L+ LDL NA+G G AL LK NS L RL L+ L D
Sbjct: 1051 AACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDC 1110
Query: 1019 AICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
++ ALS N L +NL N+ G + A PT +++
Sbjct: 1111 CEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFA--CPTSNLQI 1155
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 175 bits (444), Expect = 2e-43
Identities = 198/817 (24%), Positives = 338/817 (41%), Gaps = 51/817 (6%)
Query: 86 RLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIG 145
R L L++ Q RE + + T+ P + ++ LF P S P + G
Sbjct: 167 RYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQG 226
Query: 146 VAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEP 204
AG+GKT L R + WA G + +D F + + R+++ + LI S P P
Sbjct: 227 AAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPP 286
Query: 205 -SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSI 263
V P+R L ++DG DE + D CTD +K D L++++IR L PE S+
Sbjct: 287 IHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASL 346
Query: 264 WITSRPSASGQIPGGLVD--RMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
IT+RP A ++ L+D R EI GF+E + K + F D+A S +Q +
Sbjct: 347 LITTRPVALEKLQ-HLLDHPRHVEILGFSEAKRKEYFFKYF-SDEAQARAAFSLIQENEV 404
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+ MC +P C + + G + +G A+ +T +Y ++ L
Sbjct: 405 LFTMCFIPLVCWI--VCTGLKQQMESGKSLAQ--TSKTTTAVYVFFLSSLL--------- 451
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
PR HG + L LA G+ +K +F E D++ G LQ A S FL+
Sbjct: 452 -QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHG-----LQKADVSAFLRM 505
Query: 442 ---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSA 498
++ + Y F H++ QEF AA YY + S + P +
Sbjct: 506 NLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENY 565
Query: 499 AQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDA 558
+ E G L +RFL GL++ + L L + Q + +
Sbjct: 566 G----KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKL 621
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
+ + + +CL+E+Q + + + + T H VS C +
Sbjct: 622 QIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDH--------MVSSFCIENC 673
Query: 619 NLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQI 678
+ SLS G L ++ + + + + ++++ VL L + +
Sbjct: 674 HRVESLSLGFLHNMPKE--------EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHL 725
Query: 679 SNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK-INRTLTSLSLQGNTVRDD 737
++ + L L ++SLT LDL NS+G G + L + L+ + L L + +
Sbjct: 726 TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHE 785
Query: 738 GARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAK 796
++ L+SN+ L L L N++G G + + LK +LK+L ++ +
Sbjct: 786 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCS 845
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIA 855
AL+ L NQ L L L+ N++ D G+ L G L + L L L +++ ++
Sbjct: 846 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 905
Query: 856 HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTL 892
L ++ +L+ L L N L D G +++ L
Sbjct: 906 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 942
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/176 (28%), Positives = 86/176 (48%), Gaps = 9/176 (5%)
Query: 892 LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTA 950
L + HL +F + L L ++SLT LDL +N++GD G + L+ +
Sbjct: 720 LVNSHLTSSF-----CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRR 774
Query: 951 LYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNL 1009
L+L + + L+ N+ L LDL NA+G G + L LK + +L++L L
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 834
Query: 1010 QENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
+ L +++ LS N L H+ L+GN +GD G +++ E + P C +++
Sbjct: 835 VNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL--HPDCKLQV 888
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 169 bits (429), Expect = 1e-41
Identities = 194/817 (23%), Positives = 339/817 (41%), Gaps = 51/817 (6%)
Query: 86 RLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIG 145
R L L++ Q RE + + T+ P + ++ LF P S P + G
Sbjct: 167 RYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQG 226
Query: 146 VAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEP 204
AG+GKT L R + WA G + +D F + + R+++ + LI S P P
Sbjct: 227 AAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPP 286
Query: 205 -SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSI 263
V P+R L ++DG DE + D CTD +K D L++++IR L PE S+
Sbjct: 287 IHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASL 346
Query: 264 WITSRPSASGQIPGGLVD--RMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
IT+RP A ++ L+D R EI GF+E + K + F D+A S +Q +
Sbjct: 347 LITTRPVALEKLQ-HLLDHPRHVEILGFSEAKRKEYFFKYF-SDEAQARAAFSLIQENEV 404
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+ MC +P C + + G + +G A+ +T +Y ++ L
Sbjct: 405 LFTMCFIPLVCWI--VCTGLKQQMESGKSLAQ--TSKTTTAVYVFFLSSLL--------- 451
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
PR HG + L LA G+ +K +F E D++ G LQ A S FL+
Sbjct: 452 -QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHG-----LQKADVSAFLRM 505
Query: 442 ---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSA 498
++ + Y F H++ QEF AA YY + S + P +
Sbjct: 506 NLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENY 565
Query: 499 AQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDA 558
+ E G L +RFL GL++ + L L + Q + +
Sbjct: 566 G----KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKL 621
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
+ + + +CL+E+Q + + + + T H VS C +
Sbjct: 622 QIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDH--------MVSSFCIENC 673
Query: 619 NLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQI 678
+ SLS G L ++ + + + + ++++ VL L +
Sbjct: 674 HRVESLSLGFLHNMPKE--------EEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGL 725
Query: 679 SNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK-INRTLTSLSLQGNTVRDD 737
S++ ++ L N+ L LDL N++G G + L LK + L L L +
Sbjct: 726 SHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA 785
Query: 738 GARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAK 796
+ +A L+++ +L+ L++ +N++G G + + K + +L++L ++ +
Sbjct: 786 CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS 845
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIA 855
AL+ L NQ L L L+ N++ D G+ L G L + L L L +++ ++
Sbjct: 846 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 905
Query: 856 HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTL 892
L ++ +L+ L L N L D G +++ L
Sbjct: 906 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 942
Score = 75.9 bits (185), Expect = 2e-13
Identities = 65/213 (30%), Positives = 96/213 (45%), Gaps = 3/213 (1%)
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENR-TLTSLHLQWNFIQA 904
+S E I+ L +N L LDL+ N L D G R + V ++ L L L + +
Sbjct: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTS 784
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDG-ACAVARALKVNTALTALYLQVASIGASGA 963
Q L L + SLT L + ENA+GD G A +A L L L + + +
Sbjct: 785 ACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCC 844
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANA-LKVNSSLRRLNLQENSLGMDGAICI 1022
L L+ N+ L L LRGN +G G K L L + L+ L L +L +
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIK 1055
+T L+ + L+ ++L N +GD G M E +K
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 937
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/154 (29%), Positives = 77/154 (50%), Gaps = 4/154 (2%)
Query: 914 LQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVLGEALAV 972
L N+ L LDL +NA+GD G + LK + L L+L + ++ Q L L+
Sbjct: 737 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLST 796
Query: 973 NRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSGNHR 1031
+ +L L + NA+G +G L K +L++L L + L +++ LS N
Sbjct: 797 SHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQN 856
Query: 1032 LQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
L H+ L+GN +GD G +++ E + P C +++
Sbjct: 857 LTHLYLRGNTLGDKGIKLLCEGLL--HPDCKLQV 888
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 162 bits (409), Expect = 2e-39
Identities = 235/905 (25%), Positives = 352/905 (38%), Gaps = 137/905 (15%)
Query: 132 SRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLN------TH 185
+RV+ PRV++ +G AGMGKTTL + WA G + F + FR LN T
Sbjct: 215 TRVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL-NCFQALFLFEFRQLNLITRFLTP 273
Query: 186 EKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPV 245
+L D + H + LLI DGLDE P+ P PV
Sbjct: 274 SELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPM---------GPDGPGPV 324
Query: 246 DHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDR--MTEIRGFNEEEIKVCLEQMFP 303
L +++ G L P + TSRP G++P L M + GF+ ++ + F
Sbjct: 325 LTLFSHLCNGTLLPGCRVMATSRP---GKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFS 381
Query: 304 EDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCEL 363
+ G L ++Q + L +C VPA C++ + L HL Q L P T
Sbjct: 382 AQPSREG-ALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMT---- 436
Query: 364 YSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMK-- 421
Y +M L+ + H + LG +A GL K +FY +D+
Sbjct: 437 -QLYMQMVLA------------LSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPP 483
Query: 422 --AFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLF 479
AFG +LL C C + Y FTHLSLQEF+AA + AS + D
Sbjct: 484 LIAFGATHSLLTSF-CVCTGPGHQ----QTGYAFTHLSLQEFLAALHLM-ASPKVNKDTL 537
Query: 480 TESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEH 539
T+ ++T QR +A G D FL+GL S L S LAQG
Sbjct: 538 TQ---------YVTLHSRWVQRT-KARLGLSDHLPTFLAGLASCTCRPFL--SHLAQGNE 585
Query: 540 QAYRTQVAELLQGC--LRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTG 597
+ A ++Q L + + + HC+ E Q ELA +++ L
Sbjct: 586 DCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPY-QLPFHNF 644
Query: 598 PAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLL----YCRKLRLDTNQFQDPV 653
P LA L + + +EA + L L+ P+ L L + + D
Sbjct: 645 PLTCTDLATLTNILE--HREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAF 702
Query: 654 MELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKA 713
E L L R+Q + LA ++I+ +G L ++L + L + R N + Q
Sbjct: 703 AEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLN 761
Query: 714 LADALKINRTLTSLSLQGNTV--------------------------------------- 734
+ + L L L L N++
Sbjct: 762 IVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETT 821
Query: 735 ----------RDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELM 784
DG R A+ +R+L+ L LQK + A+ + L++ L+E+
Sbjct: 822 AELQRAPDLQESDGQRKGAQ----SRSLT-LRLQKCQLQVHDAEALIALLQEGPHLEEVD 876
Query: 785 FSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTL--LSLSLR 842
S N + D G + +AEA LDL N +S AGV ++ A+ TL L +SL+
Sbjct: 877 LSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQ 936
Query: 843 ENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFI 902
++ AQ LD L Q + ++ R R LT LQ +
Sbjct: 937 HKTVIFMFAQEPEEQKGPQERAAFLD----SLMLQMPSELPLSSRRMR-LTHCGLQEKHL 991
Query: 903 QAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASG 962
+ +ALG + L LD NA+GD+GA +A+ L AL +L L + G S
Sbjct: 992 EQ-LCKALGGSCHLGH--LHLDFSGNALGDEGAARLAQLLPGLGALQSLNL--SENGLSL 1046
Query: 963 AQVLG 967
VLG
Sbjct: 1047 DAVLG 1051
Score = 128 bits (321), Expect = 3e-29
Identities = 133/456 (29%), Positives = 201/456 (44%), Gaps = 22/456 (4%)
Query: 599 AHRAALAYLLQV-SDACAQEANLSLSLSQGVLQSLLPQLLYCRK--------LRLDTNQF 649
A RA + LL+V + A +S+S +Q Q L QL + R+ LRL
Sbjct: 1391 ADRARVLSLLEVCAQASGSVTEISISETQ---QQLCVQLEFPRQEENPEAVALRLAHCDL 1447
Query: 650 QDPVMELLGSVLSGKDCRIQKISLAENQI--SNKGAKALARSLLVNRS-LTSLDLRGNSI 706
L+G ++ R+Q++SL++ + + + L +SLL++ S L + L + +
Sbjct: 1448 GAHHSLLVGQLME-TCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCV 1506
Query: 707 GPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMG 766
+G LA L L L L N ++G +++ AL L L L +
Sbjct: 1507 STEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST 1566
Query: 767 AQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAAL 826
+ L Q L+ L + NSIGD G L+EAL+ LE LDL N I DAGV L
Sbjct: 1567 LALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHL 1626
Query: 827 MGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
L L + L NSIS G +A +L L+ L L N L D A +A +
Sbjct: 1627 ATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL 1686
Query: 887 RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
++ L LHL ++ + G A +L QAL + L + L EN + A V R
Sbjct: 1687 PQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFCMELP 1740
Query: 947 ALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRR 1006
L + L I A++L + LE++ L N +G A LA L L+R
Sbjct: 1741 LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR 1800
Query: 1007 LNLQENSLGMDGAICIATALSGNHRLQHINLQGNHI 1042
++L++N + GA +A L+ +Q I L N I
Sbjct: 1801 VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
Score = 116 bits (291), Expect = 1e-25
Identities = 135/468 (28%), Positives = 202/468 (43%), Gaps = 50/468 (10%)
Query: 538 EHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGAL--ARL 595
E A R +V LL+ C + +V +I+ +Q E R EE E+ AL A
Sbjct: 1388 EPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQ-LEFPRQ-EENPEAVALRLAHC 1445
Query: 596 TGPAHRAALAYLLQVSDACAQEANLSLS---------LSQGVLQSLLPQLLYCRKLRLDT 646
AH + L Q+ + CA+ LSLS S +LQSLL L + RL +
Sbjct: 1446 DLGAHHSLLVG--QLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTS 1503
Query: 647 NQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSL--------------LV 692
+ + L S L G ++++ L+ NQ +G KAL R+L L+
Sbjct: 1504 SCVSTEGLAHLASGL-GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLL 1562
Query: 693 NRS--------------LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDG 738
N S L SL L NSIG G L++AL+ +L L L N + D G
Sbjct: 1563 NSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAG 1622
Query: 739 ARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKAL 798
+ +A L L + L NSI G ++A++L R L+ELM N++GD A L
Sbjct: 1623 VQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL 1682
Query: 799 AEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHAL 858
A+ L Q L L L + + G +L AL + L +SL EN++ A +
Sbjct: 1683 AQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFC 1736
Query: 859 CANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNR 918
L+ +DL + + +Q A+ + + L + L WN + AA L Q L
Sbjct: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
Query: 919 SLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVL 966
L +DL++N I GA +A L +++ + L I AQ L
Sbjct: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844
Score = 100 bits (248), Expect = 1e-20
Identities = 137/529 (25%), Positives = 206/529 (38%), Gaps = 59/529 (11%)
Query: 571 LHELQHTELARSVEEAMESGALARLTGPA----HRAALAYLLQVSDACAQ---EANLSLS 623
L L H L E E R TG + H +L +LL +Q ANL
Sbjct: 1198 LRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGD 1257
Query: 624 LSQGVLQSLLPQLLYCRKLRLDTNQF-QDPVMELLGSVLS-------------------- 662
L LPQ+ L L N Q+ + LL ++ S
Sbjct: 1258 SGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIH 1317
Query: 663 -------GKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALA 715
GK R+ + S +S LA L + LT L L +G K LA
Sbjct: 1318 FSREDQAGKTLRLSECSFRPEHVSR-----LATGLSKSLQLTELTLTQCCLGQ---KQLA 1369
Query: 716 DALK-INRTLTSLSLQGNTVRDDGARSM------AEALASNRTLSMLHLQKNSIGPMGAQ 768
L + R SL+ D AR + A+A S +S+ Q+ +
Sbjct: 1370 ILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFP 1429
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI---SDAGVAA 825
R ++N L + +G + + + ++ L+ L L ++ DA
Sbjct: 1430 RQ----EENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLL 1485
Query: 826 LMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVA 885
L L + L + L + +S EG +A L L+ LDL+ N ++G +A+ A
Sbjct: 1486 LQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRA 1545
Query: 886 VRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVN 945
+ L L L + + L L L SL L N+IGD G C ++ AL+
Sbjct: 1546 LEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAA 1605
Query: 946 TALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLR 1005
T+L L L IG +G Q L L L +DL GN+I AG LA +L + L
Sbjct: 1606 TSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1665
Query: 1006 RLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAI 1054
L L N+LG A+ +A L + R+ H L +H+G GA +++A+
Sbjct: 1666 ELMLGCNALGDPTALGLAQELPQHLRVLH--LPFSHLGPGGALSLAQAL 1712
Score = 70.9 bits (172), Expect = 6e-12
Identities = 98/378 (25%), Positives = 146/378 (38%), Gaps = 38/378 (10%)
Query: 699 LDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758
LD G + P +AL +I +LS + D A +++ +L + L ML L
Sbjct: 667 LDFDGCPLEPHCPEALVGCGQIE----NLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLA 722
Query: 759 KNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
+ I G + AL LKE+ F N + D + E L L LDL SNSI
Sbjct: 723 GSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSI 782
Query: 819 SDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQG 878
+ + L T T+ L RE A I T L +L G
Sbjct: 783 CVSTLLCLARVAVTCPTVRMLQARE-------ADLIFLLSPPTETTAELQRAPDLQESDG 835
Query: 879 ARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAV 938
R A ++R+LT L LQ +Q A+AL LQ L +DL N + D+G +
Sbjct: 836 QRKGA----QSRSLT-LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLM 890
Query: 939 ARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEIL--DLRGNAI---------- 986
A A L L + +G + A++ TL L L+ +
Sbjct: 891 AEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEE 950
Query: 987 --GVAGAKALANALKVNS------SLRRLNLQENSLGMDGAICIATALSGNHRLQHINL- 1037
G A ++L + S RR+ L L + AL G+ L H++L
Sbjct: 951 QKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLD 1010
Query: 1038 -QGNHIGDSGARMISEAI 1054
GN +GD GA +++ +
Sbjct: 1011 FSGNALGDEGAARLAQLL 1028
Score = 66.6 bits (161), Expect = 1e-10
Identities = 96/405 (23%), Positives = 150/405 (37%), Gaps = 55/405 (13%)
Query: 678 ISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD 737
+S + ++L L + L+ +DL N +G G + L + L L L N++ +
Sbjct: 1227 LSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQE 1286
Query: 738 GARSMAEALAS------------------------NRTLSMLHLQKNSIGPMGAQRMADA 773
A + E L S ++ L L + S P R+A
Sbjct: 1287 SALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATG 1346
Query: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTN 833
L ++ L EL + +G L + GL SL +Q A V +L+ +C
Sbjct: 1347 LSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLL-EVCAQ 1405
Query: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLT 893
S S+ E SIS Q LC + EN
Sbjct: 1406 A---SGSVTEISISETQQQ-----LCVQLEFPRQE-------------------ENPEAV 1438
Query: 894 SLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAI--GDDGACAVARALKVNTA-LTA 950
+L L + A + +GQ ++ L L L + + DD + + ++L ++ + L
Sbjct: 1439 ALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKT 1498
Query: 951 LYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQ 1010
L + + G L L LE LDL N G KAL AL+ L+RL+L
Sbjct: 1499 FRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLS 1558
Query: 1011 ENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIK 1055
L + LS LQ + L N IGD G +SEA++
Sbjct: 1559 HLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALR 1603
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/439 (20%), Positives = 156/439 (35%), Gaps = 57/439 (12%)
Query: 663 GKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR 722
G R + L + Q+ A+AL L L +DL GN + +G + +A+A
Sbjct: 839 GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLH 898
Query: 723 TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLH--LQKNSI------------GPMGAQ 768
L L N + G + A+++ TL+ LH LQ ++ GP
Sbjct: 899 IARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERA 958
Query: 769 RMADALKQNR------SLKELMFSSNSIGDGGAKALAEAL--KVNQGLESLDLQSNSISD 820
D+L S + + + + + + L +AL + G LD N++ D
Sbjct: 959 AFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGD 1018
Query: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGAR 880
G A L L L SL+L EN +S + + L LD++ H
Sbjct: 1019 EGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQH----- 1073
Query: 881 AIAVAVRENRTLTSLHLQWNFIQ-AGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVA 939
+ +R ++T + + AA+ LG + SL L E + +
Sbjct: 1074 ---ILLRGDKTSRDMWATGSLPDFPAAAKFLG--FRQRCIPRSLCLSECPLEPPSLTRLC 1128
Query: 940 RALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK 999
LK L L + + L + L L +L L + LAN L
Sbjct: 1129 ATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLS 1188
Query: 1000 VNSSLRRLNLQE------------------------NSLGMDGAICIATALSGNHRLQHI 1035
+ +++++L+ SL + + LS L +
Sbjct: 1189 LCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQV 1248
Query: 1036 NLQGNHIGDSGARMISEAI 1054
+L N +GDSG R + E +
Sbjct: 1249 DLSANLLGDSGLRCLLECL 1267
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 157 bits (397), Expect = 5e-38
Identities = 187/779 (24%), Positives = 320/779 (41%), Gaps = 51/779 (6%)
Query: 86 RLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIG 145
R L L++ Q RE + + T+ P + ++ LF P S P + G
Sbjct: 167 RYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQG 226
Query: 146 VAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEP 204
AG+GKT L R + WA G + +D F + + R+++ + LI S P P
Sbjct: 227 AAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPP 286
Query: 205 -SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSI 263
V P+R L ++DG DE + D CTD +K D L++++IR L PE S+
Sbjct: 287 IHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASL 346
Query: 264 WITSRPSASGQIPGGLVD--RMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
IT+RP A ++ L+D R EI GF+E + K + F D+A S +Q +
Sbjct: 347 LITTRPVALEKLQ-HLLDHPRHVEILGFSEAKRKEYFFKYF-SDEAQARAAFSLIQENEV 404
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+ MC +P C + + G + +G A+ +T +Y ++ L
Sbjct: 405 LFTMCFIPLVCWI--VCTGLKQQMESGKSLAQ--TSKTTTAVYVFFLSSLL--------- 451
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
PR HG + L LA G+ +K +F E D++ G LQ A S FL+
Sbjct: 452 -QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHG-----LQKADVSAFLRM 505
Query: 442 ---EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSA 498
++ + Y F H++ QEF AA YY + S + P +
Sbjct: 506 NLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENY 565
Query: 499 AQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDA 558
+ E G L +RFL GL++ + L L + Q + +
Sbjct: 566 G----KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKL 621
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
+ + + +CL+E+Q + + + + T H VS C +
Sbjct: 622 QIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDH--------MVSSFCIENC 673
Query: 619 NLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQI 678
+ SLS G L ++ + + + + ++++ VL L +
Sbjct: 674 HRVESLSLGFLHNMPKE--------EEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGL 725
Query: 679 SNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK-INRTLTSLSLQGNTVRDD 737
S++ ++ L N+ L LDL N++G G + L LK + L L L + +
Sbjct: 726 SHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSV 785
Query: 738 GARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADA-LKQNRSLKELMFSSNSIGDGGAK 796
+++ L++N+ L+ L+L+ N++G G + + + L + L+ L + ++
Sbjct: 786 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 845
Query: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENSISPEGAQAI 854
L+ L +Q L L L +N + D GV L LL +L L E + E A+
Sbjct: 846 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 904
Score = 61.2 bits (147), Expect = 5e-09
Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 2/144 (1%)
Query: 914 LQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVLGEALAV 972
L N+ L LDL +NA+GD G + LK + L L+L + + + L L+
Sbjct: 737 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLST 796
Query: 973 NRTLEILDLRGNAIGVAGAKALANA-LKVNSSLRRLNLQENSLGMDGAICIATALSGNHR 1031
N+ L L LRGN +G G K L L + L+ L L +L ++T L+ +
Sbjct: 797 NQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQS 856
Query: 1032 LQHINLQGNHIGDSGARMISEAIK 1055
L+ ++L N +GD G M E +K
Sbjct: 857 LRKLSLGNNDLGDLGVMMFCEVLK 880
Score = 48.1 bits (113), Expect = 4e-05
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 3/97 (3%)
Query: 970 LAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSG 1028
L+ N+ L LDL NA+G G + L LK + +L++L L + L +++ LS
Sbjct: 737 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLST 796
Query: 1029 NHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
N L H+ L+GN +GD G +++ E + P C +++
Sbjct: 797 NQNLTHLYLRGNTLGDKGIKLLCEGLL--HPDCKLQV 831
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 155 bits (391), Expect = 2e-37
Identities = 212/891 (23%), Positives = 365/891 (40%), Gaps = 87/891 (9%)
Query: 124 LDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDL 182
L RL P +R + + +G AG+GKTTL + WA+G + + FS V L+ +
Sbjct: 215 LQRLLDP-NRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKI 273
Query: 183 NTHEKLCADRLICSVFPHVGEP-SLAVAVPARALLILDGLDECRTPLDFSNTV----ACT 237
++ LI +P P ++ P + L I+DG +E S ++ CT
Sbjct: 274 RYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCT 333
Query: 238 DPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDR-MTEIRGFNEEEIKV 296
D +E+PV ++ ++++ L P ++ IT + + LV+ +I GF ++++V
Sbjct: 334 DWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRV 393
Query: 297 CLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWP 356
+ F +D + + +L Q++ + L+ C+ P C L + + D +
Sbjct: 394 YFMRHF-DDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLK---QPKVRYYDLQSIT 449
Query: 357 PRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFY 416
+T LY+++F S + ++ L LA GL + F
Sbjct: 450 -QTTTSLYAYFFSNLFS---------TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFN 499
Query: 417 EQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIF 476
++D + G+++ + LQ+ FTHLS QEF AA + R
Sbjct: 500 KEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTT--FTHLSFQEFFAAMSFVLEEPREFP 557
Query: 477 DLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQ 536
T+ + Q + ++ + F GLL+ + L +L +
Sbjct: 558 PHSTKP----------QEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCK 607
Query: 537 GEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLT 596
+ + + A++ + + HCLHE Q + + + + L L
Sbjct: 608 ISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILE 667
Query: 597 GPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMEL 656
+A+ L C + L LS+S +L+ L L +T++F D M
Sbjct: 668 DEELQASSFCLKH----CKRLNKLRLSVSSHILERDLEIL--------ETSKF-DSRMHA 714
Query: 657 LGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALAD 716
S+ S +L+ N +L LDL + + K L
Sbjct: 715 WNSICS--------------------------TLVTNENLHELDLSNSKLHASSVKGLCL 748
Query: 717 ALKINRT----LTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMAD 772
ALK R LT S+ V D + AL N L+ L+ N +G M +
Sbjct: 749 ALKNPRCKVQKLTCKSVTPEWVLQD----LIIALQGNSKLTHLNFSSNKLG-MTVPLILK 803
Query: 773 ALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALC 831
AL+ + +LK L ++ + LA L Q + L L N + D G+ L AL
Sbjct: 804 ALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALT 863
Query: 832 TNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-REN 889
+ L L L ++ + ++ AL N +L +L+L+ N L D+G + + A+ R +
Sbjct: 864 HPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPD 923
Query: 890 RTLTSLHLQW-NFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTAL 948
L SL+L +F + G + L AL N ++ LDL EN + DDG + ALK + AL
Sbjct: 924 GNLQSLNLSGCSFTREGCGE-LANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRAL 982
Query: 949 TALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK 999
L L ++ + Q L L+ +++L L+L GN + G K L ALK
Sbjct: 983 HTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALK 1033
Score = 100 bits (249), Expect = 7e-21
Identities = 90/326 (27%), Positives = 148/326 (45%), Gaps = 4/326 (1%)
Query: 741 SMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAE 800
S+ L +N L L L + + + + ALK R + + + + + L
Sbjct: 717 SICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLII 776
Query: 801 ALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCA 860
AL+ N L L+ SN + L + L L L + ++S Q +A L +
Sbjct: 777 ALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
Query: 861 NSTLKNLDLTANLLHDQGARAIAVAVRENR-TLTSLHLQWNFIQAGAAQALGQALQLNRS 919
+ L L N L D G + + A+ + L L L + + A A + L AL NRS
Sbjct: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Query: 920 LTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEI 978
LT L+L +N++ D+G + AL + + L +L L S G L AL+ N ++I
Sbjct: 897 LTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKI 956
Query: 979 LDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQ 1038
LDL N + G K L ALK + +L L L + +L + + LS + L ++NL
Sbjct: 957 LDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLL 1016
Query: 1039 GNHIGDSGARMISEAIKTNAPTCTVE 1064
GN + G +M+ +A+K + TC ++
Sbjct: 1017 GNELDTDGVKMLCKALKKS--TCRLQ 1040
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/136 (27%), Positives = 67/136 (49%)
Query: 642 LRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDL 701
L L N +D ++ L L D +Q ++L+ + +G LA +L N ++ LDL
Sbjct: 900 LNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDL 959
Query: 702 RGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNS 761
N + G K L +ALK +R L +L L + + + L+S+++L L+L N
Sbjct: 960 GENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNE 1019
Query: 762 IGPMGAQRMADALKQN 777
+ G + + ALK++
Sbjct: 1020 LDTDGVKMLCKALKKS 1035
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 142 bits (357), Expect = 2e-33
Identities = 211/850 (24%), Positives = 354/850 (41%), Gaps = 96/850 (11%)
Query: 124 LDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDL 182
LDRLF P PR I G G+GKTTL+ + W+ ++ +D F R+L
Sbjct: 135 LDRLFAP-KEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCREL 193
Query: 183 NTHEKLCADRLICSVFPHVGEP-SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKK 241
LI +P P + V+ P R L ++D +E + L+ ++ C D +
Sbjct: 194 RELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLME 253
Query: 242 EIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGL-VDRMTEIRGFNEEEIKVCLEQ 300
+ PV L+++++R + PE S+ I +P ++ + + + + RGFNE + V
Sbjct: 254 KRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCC 313
Query: 301 MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL 360
F + + + + V+ L+ +C +P C + +L + +D L T
Sbjct: 314 FFKDPKRAME-AFNLVRESEQLFSICQIPLLCWILCTSLK---QEMQKGKDLALTCQSTT 369
Query: 361 CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM 420
S+ F + + EG E +P+ + + L LA G+ + F E D+
Sbjct: 370 SVYSSFVFNL-FTPEGAE--GPTPQTQH-------QLKALCSLAAEGMWTDTFEFCEDDL 419
Query: 421 KAFGV---DLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASR----- 472
+ GV D+ L G E+ +Y F H+ +QEF AA +Y S
Sbjct: 420 RRNGVVDADIPALLGTKILLKYGERES-----SYVFLHVCIQEFCAALFYLLKSHLDHPH 474
Query: 473 ---RAIFDLFTES-----GVSWPRLG-FLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSP 523
R + +L + W LG FLT + + E +LD F F LS
Sbjct: 475 PAVRCVQELLVANFEKARRAHWIFLGCFLTGLLN------KKEQEKLDAFFGF---QLSQ 525
Query: 524 RVNALLAGSLLAQGEHQAYRTQVAEL-LQGCL--RPDAAVCARAINVLH--CLHELQHTE 578
+ + L + GE + QV L + CL D A +A+N+L H + + +
Sbjct: 526 EIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVD 585
Query: 579 LARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLY 638
L S +L +L ++ + + D + ++ SL + S+L +
Sbjct: 586 LVVSAYCLKYCSSLRKLC-----FSVQNVFKKEDEHSSTSDYSLICWHHIC-SVLTTSGH 639
Query: 639 CRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLL------- 691
R+L++ + + + L CR+QK+ + N +S G L +L
Sbjct: 640 LRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGI--NNVSFSGQSVLLFEVLFYQPDLK 697
Query: 692 -VNRSLTSL---DLR----------GN---------SIGPQGAKALADALKINRTLTSLS 728
++ +LT L D+R GN + P + LA L N+ LT L+
Sbjct: 698 YLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLN 757
Query: 729 LQGNTVRDDGARSMAEALASNRT-LSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSS 787
+ N + D G + EAL S T L L L + + +++ L +N+S++ L S+
Sbjct: 758 VSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSA 816
Query: 788 NSIGDGGAKALAEALK-VNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSI 846
N + D G K L EALK + L+SL L I+ AG L AL +NQ L L + N I
Sbjct: 817 NVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEI 876
Query: 847 SPEGAQAIAHALC-ANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAG 905
G Q + AL + L+ L L L + +A + ++TL L+L N +
Sbjct: 877 GDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHT 936
Query: 906 AAQALGQALQ 915
L +AL+
Sbjct: 937 GVVVLCEALR 946
Score = 77.8 bits (190), Expect = 5e-14
Identities = 80/294 (27%), Positives = 131/294 (44%), Gaps = 13/294 (4%)
Query: 776 QNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL-CTNQ 834
Q + + FS S+ L E L L+ L +S + +L AL
Sbjct: 670 QKLGINNVSFSGQSV------LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAG 723
Query: 835 TLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRT-LT 893
+ L+L +SP + +A L N L L+++ N L D G + A+ T L
Sbjct: 724 NVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLV 782
Query: 894 SLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALY 952
L L + + + + + L N+S+ LDL N + D+G + ALK + L +L
Sbjct: 783 YLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLC 842
Query: 953 LQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQE 1011
L I A+G + L AL N+ L+IL + N IG G + L AL + L L L+E
Sbjct: 843 LVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEE 902
Query: 1012 NSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
L +A+ L+ + LQ +NL N + +G ++ EA++ P C +++
Sbjct: 903 CGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALR--HPECALQV 954
Score = 53.5 bits (127), Expect = 1e-06
Identities = 65/266 (24%), Positives = 107/266 (40%), Gaps = 16/266 (6%)
Query: 798 LAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIA-H 856
+ L + L L +Q +++S++ L L L N++S G +
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQ-KLGINNVSFSGQSVLLFE 688
Query: 857 ALCANSTLKNLDLTANLLHDQGARAIAVAVR------ENRTLTSLHLQWNFIQAGAAQAL 910
L LK L T L R++ A+ + L + HL + L
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS-----PIDCEVL 743
Query: 911 GQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGAQVLGEA 969
L N+ LT L++ N + D G + AL +T L L L + + + E
Sbjct: 744 AGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEM 802
Query: 970 LAVNRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSG 1028
L N+++ LDL N + G K L ALK + L L L + + G +A+AL
Sbjct: 803 LLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALIS 862
Query: 1029 NHRLQHINLQGNHIGDSGARMISEAI 1054
N L+ + + N IGD G +++ A+
Sbjct: 863 NQNLKILQIGCNEIGDVGVQLLCRAL 888
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 134 bits (338), Expect = 3e-31
Identities = 213/890 (23%), Positives = 370/890 (41%), Gaps = 93/890 (10%)
Query: 128 FLPLSRVSVP----PRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLN 183
F+P P P + G AG+GKTTL + + W + L+ ++L+
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELS 216
Query: 184 THEKLCADRLICSVFPHVGE--PSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKK 241
LI +P + + PS+ +A R L ++DGLDE + P C D +K
Sbjct: 217 RMGPCSFAELISKDWPELQDDIPSI-LAQAQRILFVVDGLDELKVPPGALIQDICGDWEK 275
Query: 242 EIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRM---TEIRGFNEEEIKVCL 298
+ PV L+ ++++ + P ++ +T+RP A + L+ + + GF EE+ +
Sbjct: 276 KKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ--LLAQQPIYVRVEGFLEEDRRAYF 333
Query: 299 EQMF-PEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPP 357
+ F EDQA+ + L ++++ AL+ + + PA C + L P L
Sbjct: 334 LRHFGDEDQAMRAFEL--MRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 358 ----RTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKY 413
R LC + P+ Q+ R + TL LA GL +
Sbjct: 392 GLFLRFLCSRF-------------------PQGAQL----RGALRTLSLLAAQGLWAQMS 428
Query: 414 VFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRR 473
VF+ +D++ GV + L+ L+++ S Y F HLS Q+F+ A +Y
Sbjct: 429 VFHREDLERLGVQESDLRLFLDGDILRQDRV--SKGCYSFIHLSFQQFLTALFYALEKEE 486
Query: 474 AIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSL 533
G +W +G + S +R + ++ FL L+ + G
Sbjct: 487 GE----DRDGHAWD-IGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCR 541
Query: 534 LAQGEHQAYRTQVAELLQ--GCLRPDAAVCARAIN-VLHCLHELQHTELARSVEEAMESG 590
++ Q ELLQ L + + + VL CL+E Q ELA+ V +
Sbjct: 542 MSPDIKQ-------ELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEI 594
Query: 591 ALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGV-LQSLLPQLL---------YCR 640
++ LT + ++ L+ C LSL +++GV L++ + L +
Sbjct: 595 SI-HLTNTSEVMHCSFSLK---HCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLK 650
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
L + + D + +L ++ C +QK+ + +N + + + + ++LT L
Sbjct: 651 FLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEI-KNVTPDTAYRDFCLAFIGKKTLTHLT 709
Query: 701 LRGNSIGPQGAK-ALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758
L G+ + L D L+ ++ L L L G+ + L +N++L L L
Sbjct: 710 LAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLS 769
Query: 759 KNSIGPMGAQRMADALKQNRSLKELMFSSN-SIGDGGAKALAEALKVNQGLESLDLQSNS 817
N + GA + + + + +++ N + + K LA L V++ L L L N
Sbjct: 770 ANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNP 829
Query: 818 ISDAGVAALMGAL----CTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANL 873
I D GV L L C QTL+ L++ SI+ G + ++ AL +L NLDL+ N
Sbjct: 830 IGDTGVKFLCEGLSYPDCKLQTLV---LQQCSITKLGCRYLSEALQEACSLTNLDLSIN- 885
Query: 874 LHDQGARAIAVAVR--ENRTLTSLHLQ-WN-FIQAGAAQALGQALQLNRSLTSLDLQENA 929
Q AR + + + EN HL+ W+ + Q LG AL N+ L +LDL +N
Sbjct: 886 ---QIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNH 942
Query: 930 IGDDGACAVARALKVNT-ALTALYLQVASIGASGAQVLGEALAVNRTLEI 978
+ G + L+ T +L L L+ ++L E N L I
Sbjct: 943 LWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
Score = 75.9 bits (185), Expect = 2e-13
Identities = 83/305 (27%), Positives = 134/305 (43%), Gaps = 6/305 (1%)
Query: 747 ASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806
+SN L L ++++ + + + D + ++ + + N D + A +
Sbjct: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKK 703
Query: 807 GLESLDLQSNSISDAGVAALMGALCTNQ--TLLSLSLRENSISPEGAQAIAHALCANSTL 864
L L L + + + ++ L N L L L + +PE + L AN +L
Sbjct: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
Query: 865 KNLDLTANLLHDQGARAI-AVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSL 923
K+L L+AN+L D+GA + R L L L+ + + + L L +++ LT L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 823
Query: 924 DLQENAIGDDGACAVARALKV-NTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLR 982
L +N IGD G + L + L L LQ SI G + L EAL +L LDL
Sbjct: 824 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 883
Query: 983 GNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNH 1041
N I G L AL+ N +L+ L L SL + +AL N +L+ ++L NH
Sbjct: 884 INQI-ARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNH 942
Query: 1042 IGDSG 1046
+ SG
Sbjct: 943 LWKSG 947
Score = 37.7 bits (86), Expect = 0.058
Identities = 51/212 (24%), Positives = 89/212 (41%), Gaps = 13/212 (6%)
Query: 860 ANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQW----NFIQAGAAQALGQALQ 915
+NS LK L++ + L D R + ++ T ++ HLQ N A + A
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILC----DHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI 700
Query: 916 LNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQ--VLGEALAVN 973
++LT L L + + + L N YL++ A+ Q L N
Sbjct: 701 GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKAN 760
Query: 974 RTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICIATALSGNHRL 1032
++L+ L L N + GA L + + L+ L+L+ L +A L + +L
Sbjct: 761 QSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL 820
Query: 1033 QHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
H+ L N IGD+G + + E + + P C ++
Sbjct: 821 THLCLAKNPIGDTGVKFLCEGL--SYPDCKLQ 850
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 132 bits (331), Expect = 2e-30
Identities = 90/255 (35%), Positives = 130/255 (50%), Gaps = 3/255 (1%)
Query: 778 RSLKELMFSSN--SIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQT 835
R+++E + N +G G KA+A AL N + L+L+ N I + GV +L+ L N
Sbjct: 103 RNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYY 162
Query: 836 LLSLSLRENSISPEGAQAIAHALCANST-LKNLDLTANLLHDQGARAIAVAVRENRTLTS 894
L +++ N + EGA+ I+ NS+ + +L+L+ N + A + A+ N +
Sbjct: 163 LQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKK 222
Query: 895 LHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQ 954
L L N + LGQ L +N LTSLDL N GA A+ L+ N LT L L
Sbjct: 223 LDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLS 282
Query: 955 VASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSL 1014
+ G A LGE L +NR L LD+ GN IG GA ++ L+ N SLR L L N +
Sbjct: 283 MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPI 342
Query: 1015 GMDGAICIATALSGN 1029
MDGAI + A+ N
Sbjct: 343 NMDGAILLILAIKRN 357
Score = 129 bits (323), Expect = 2e-29
Identities = 92/290 (31%), Positives = 142/290 (48%), Gaps = 3/290 (1%)
Query: 693 NRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTL 752
N + ++L + +GP+G KA+A AL N +T L L+ N + ++G S+ E L N L
Sbjct: 104 NMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYL 163
Query: 753 SMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKVNQGLESL 811
+++ N +G GA+ ++D ++N S + L S N + A L +AL N ++ L
Sbjct: 164 QEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKL 223
Query: 812 DLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTA 871
DL N SD G L L N L SL L N+ GA A+ + L N TL LDL+
Sbjct: 224 DLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSM 283
Query: 872 NLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIG 931
N ++ A A+ +R NR L L + N I A + + L+ N SL L L N I
Sbjct: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343
Query: 932 DDGACAVARALKVNTALTALYLQVASIGASG--AQVLGEALAVNRTLEIL 979
DGA + A+K N L ++++ S + L AV+ L+++
Sbjct: 344 MDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
Score = 108 bits (269), Expect = 4e-23
Identities = 80/248 (32%), Positives = 119/248 (47%), Gaps = 1/248 (0%)
Query: 811 LDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLT 870
++L + + G A+ AL +N + L L +N I EG ++ L N L+ ++++
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
Query: 871 ANLLHDQGARAIA-VAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENA 929
N L +GAR I+ R + ++ SL L N + +A L QAL N + LDL N
Sbjct: 170 NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
Query: 930 IGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVA 989
D G + + L +N LT+L L + GA L L N TL LDL N G
Sbjct: 230 FSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNE 289
Query: 990 GAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARM 1049
A AL L++N L L++ N +G +GA I+ L N L+ + L N I GA +
Sbjct: 290 VALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
Query: 1050 ISEAIKTN 1057
+ AIK N
Sbjct: 350 LILAIKRN 357
Score = 98.2 bits (243), Expect = 4e-20
Identities = 71/210 (33%), Positives = 107/210 (50%), Gaps = 3/210 (1%)
Query: 642 LRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDL 701
L L N F++ LL LS + +I+K+ L+ NQ S+ G + L + L +N LTSLDL
Sbjct: 195 LELSGNDFKEDSAALLCQALS-TNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDL 253
Query: 702 RGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNS 761
N+ +GA AL + L+ N TLT L L N ++ A ++ E L NR L L + N
Sbjct: 254 SWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGND 313
Query: 762 IGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVN--QGLESLDLQSNSIS 819
IG GA +++ L+ N SL+ L N I GA L A+K N +E LD+ + +S
Sbjct: 314 IGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVS 373
Query: 820 DAGVAALMGALCTNQTLLSLSLRENSISPE 849
+ + L G + L + +SP+
Sbjct: 374 EQFMKTLDGVYAVHPQLDVVFKAVQGLSPK 403
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/275 (26%), Positives = 114/275 (41%), Gaps = 14/275 (5%)
Query: 597 GPAHRAALAYLLQVSDACAQ-EANLSLSLSQGVLQ--SLLPQLLYCRKLRLDTNQFQDPV 653
GP A+A L + A + E + + +GVL +L + Y +++ + N
Sbjct: 118 GPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEG 177
Query: 654 MELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKA 713
++ I + L+ N A L ++L N + LDL N G +
Sbjct: 178 ARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH 237
Query: 714 LADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADA 773
L L IN LTSL L N GA ++ L N TL+ L L N G A + +
Sbjct: 238 LGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEV 297
Query: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTN 833
L+ NR L L N IG+ GA +++ L+ N+ L L L N I+ G
Sbjct: 298 LRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGA---------- 347
Query: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLD 868
LL L+++ N S I++ L + +K LD
Sbjct: 348 -ILLILAIKRNPKSRMEELDISNVLVSEQFMKTLD 381
Score = 57.8 bits (138), Expect = 5e-08
Identities = 27/80 (33%), Positives = 49/80 (61%)
Query: 979 LDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQ 1038
++L + +G G KA+A AL N ++ +L L++N + +G + + L N+ LQ +N+
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
Query: 1039 GNHIGDSGARMISEAIKTNA 1058
NH+G GAR+IS+ + N+
Sbjct: 170 NNHLGLEGARIISDFFERNS 189
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 129 bits (324), Expect = 1e-29
Identities = 181/738 (24%), Positives = 290/738 (39%), Gaps = 102/738 (13%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQV-GKDFSLVLPLTFRDLNTHEKLCADRLICS 196
PR+ I G AG+GK+TL R W GQ+ G F V + R+L A + S
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL-------AQSKVVS 379
Query: 197 VFPHVGEPSLAVAVPARALL--------ILDGLDECRTPLDFSNTVACTDPKKEIPVDHL 248
+ +G+ A P R +L ILDG+DE L ++ C + P D L
Sbjct: 380 LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADAL 439
Query: 249 ITNIIRGNLFPEVSIWITSRPSA-SGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPED-Q 306
+ +++ + PE S IT+R +A IP R E+ GF+E K + F ++ Q
Sbjct: 440 LGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQ 499
Query: 307 ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSW 366
A+ + L V++++ L+ +C VP L L + + + +T L
Sbjct: 500 AIRAFRL--VKSNKELWALCLVPWVSWLACTCLMQQMKRK----EKLTLTSKTTTTLCLH 553
Query: 367 YFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVD 426
Y AL + P++ L LA G+ +KK +F D++ G+D
Sbjct: 554 YLAQALQAQ-----PLGPQLRD-----------LCSLAAEGIWQKKTLFSPDDLRKHGLD 597
Query: 427 LALLQGAPCSCFLQRE--ETLASSVAYCFTHLSLQEFVAAAYYY-------GASRRAIFD 477
GA S FL+ + ++Y F HL QEF AA Y G I D
Sbjct: 598 -----GAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIID 652
Query: 478 LFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQG 537
L ++ ++A + GL L G L +G
Sbjct: 653 L---------------------EKTLEAYG---------IHGLFGASTTRFLLGLLSDEG 682
Query: 538 EHQAYR------TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
E + +Q L+Q + ++ LHCL+E ++ V E
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMG 742
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD 651
+ T + ++ S L L + + P ++ + T D
Sbjct: 743 MCVET-DMELLVCTFCIKFS---RHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVT----D 794
Query: 652 PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS-LTSLDLRGNSIGPQG 710
++L SVL ++++ L+ N +S+ K+L ++L R L +L L G + +
Sbjct: 795 AYWQILFSVLK-VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQR 769
K LA L+ N+TLT L L N + D GA+ + + L + L L L + Q
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ-GLESLDLQSNSISDAGVAALMG 828
+A L + SLKEL N++ D G + L E L+ L L L ++SD L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 829 ALCTNQTLLSLSLRENSI 846
LL S R+ S+
Sbjct: 974 LEQEKPQLLIFSRRKPSV 991
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 690 LLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT-SLSLQGNTVRDDGARSMAEALAS 748
L V R+L LDL GNS+ K+L L+ R L +L L G + + + +A L +
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRA 863
Query: 749 NRTLSMLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQG 807
N+TL+ L L N + GA+ + L+Q + L+ L S + + LA L +
Sbjct: 864 NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPS 923
Query: 808 LESLDLQSNSISDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAI 854
L+ LDLQ N++ D GV L G L+ L L + ++S E Q +
Sbjct: 924 LKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSL 841
++F + D + L LKV + L+ LDL NS+S + V +L L + LL +L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWN 900
++ E + +A L AN TL LDL+ N+L D GA+ + +R+ + L L L
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943
+ + Q L L + SL LDLQ+N + D G + L+
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVL 966
Q L L++ R+L LDL N++ ++ + L+ L L L + A + L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 967 GEALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATA 1025
L N+TL LDL N + AGAK L L+ S L+RL L L D +A+
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTC 1061
LS + L+ ++LQ N++ D G R++ E ++ P C
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLR--HPAC 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
Q+L L V R L+ LDL GN++ + K+L L + L L L L + +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L N L ++L N + D+GA+ + + ++ P+C ++
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR--QPSCKLQ 897
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 129 bits (324), Expect = 1e-29
Identities = 181/738 (24%), Positives = 290/738 (39%), Gaps = 102/738 (13%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQV-GKDFSLVLPLTFRDLNTHEKLCADRLICS 196
PR+ I G AG+GK+TL R W GQ+ G F V + R+L A + S
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL-------AQSKVVS 379
Query: 197 VFPHVGEPSLAVAVPARALL--------ILDGLDECRTPLDFSNTVACTDPKKEIPVDHL 248
+ +G+ A P R +L ILDG+DE L ++ C + P D L
Sbjct: 380 LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADAL 439
Query: 249 ITNIIRGNLFPEVSIWITSRPSA-SGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPED-Q 306
+ +++ + PE S IT+R +A IP R E+ GF+E K + F ++ Q
Sbjct: 440 LGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQ 499
Query: 307 ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSW 366
A+ + L V++++ L+ +C VP L L + + + +T L
Sbjct: 500 AIRAFRL--VKSNKELWALCLVPWVSWLACTCLMQQMKRK----EKLTLTSKTTTTLCLH 553
Query: 367 YFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVD 426
Y AL + P++ L LA G+ +KK +F D++ G+D
Sbjct: 554 YLAQALQAQ-----PLGPQLRD-----------LCSLAAEGIWQKKTLFSPDDLRKHGLD 597
Query: 427 LALLQGAPCSCFLQRE--ETLASSVAYCFTHLSLQEFVAAAYYY-------GASRRAIFD 477
GA S FL+ + ++Y F HL QEF AA Y G I D
Sbjct: 598 -----GAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIID 652
Query: 478 LFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQG 537
L ++ ++A + GL L G L +G
Sbjct: 653 L---------------------EKTLEAYG---------IHGLFGASTTRFLLGLLSDEG 682
Query: 538 EHQAYR------TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
E + +Q L+Q + ++ LHCL+E ++ V E
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMG 742
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD 651
+ T + ++ S L L + + P ++ + T D
Sbjct: 743 MCVET-DMELLVCTFCIKFS---RHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVT----D 794
Query: 652 PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS-LTSLDLRGNSIGPQG 710
++L SVL ++++ L+ N +S+ K+L ++L R L +L L G + +
Sbjct: 795 AYWQILFSVLK-VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQR 769
K LA L+ N+TLT L L N + D GA+ + + L + L L L + Q
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ-GLESLDLQSNSISDAGVAALMG 828
+A L + SLKEL N++ D G + L E L+ L L L ++SD L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 829 ALCTNQTLLSLSLRENSI 846
LL S R+ S+
Sbjct: 974 LEQEKPQLLIFSRRKPSV 991
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 690 LLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT-SLSLQGNTVRDDGARSMAEALAS 748
L V R+L LDL GNS+ K+L L+ R L +L L G + + + +A L +
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRA 863
Query: 749 NRTLSMLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQG 807
N+TL+ L L N + GA+ + L+Q + L+ L S + + LA L +
Sbjct: 864 NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPS 923
Query: 808 LESLDLQSNSISDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAI 854
L+ LDLQ N++ D GV L G L+ L L + ++S E Q +
Sbjct: 924 LKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSL 841
++F + D + L LKV + L+ LDL NS+S + V +L L + LL +L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWN 900
++ E + +A L AN TL LDL+ N+L D GA+ + +R+ + L L L
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943
+ + Q L L + SL LDLQ+N + D G + L+
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVL 966
Q L L++ R+L LDL N++ ++ + L+ L L L + A + L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 967 GEALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATA 1025
L N+TL LDL N + AGAK L L+ S L+RL L L D +A+
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTC 1061
LS + L+ ++LQ N++ D G R++ E ++ P C
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLR--HPAC 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
Q+L L V R L+ LDL GN++ + K+L L + L L L L + +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L N L ++L N + D+GA+ + + ++ P+C ++
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR--QPSCKLQ 897
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 129 bits (324), Expect = 1e-29
Identities = 181/738 (24%), Positives = 290/738 (39%), Gaps = 102/738 (13%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQV-GKDFSLVLPLTFRDLNTHEKLCADRLICS 196
PR+ I G AG+GK+TL R W GQ+ G F V + R+L A + S
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL-------AQSKVVS 379
Query: 197 VFPHVGEPSLAVAVPARALL--------ILDGLDECRTPLDFSNTVACTDPKKEIPVDHL 248
+ +G+ A P R +L ILDG+DE L ++ C + P D L
Sbjct: 380 LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADAL 439
Query: 249 ITNIIRGNLFPEVSIWITSRPSA-SGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPED-Q 306
+ +++ + PE S IT+R +A IP R E+ GF+E K + F ++ Q
Sbjct: 440 LGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQ 499
Query: 307 ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSW 366
A+ + L V++++ L+ +C VP L L + + + +T L
Sbjct: 500 AIRAFRL--VKSNKELWALCLVPWVSWLACTCLMQQMKRK----EKLTLTSKTTTTLCLH 553
Query: 367 YFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVD 426
Y AL + P++ L LA G+ +KK +F D++ G+D
Sbjct: 554 YLAQALQAQ-----PLGPQLRD-----------LCSLAAEGIWQKKTLFSPDDLRKHGLD 597
Query: 427 LALLQGAPCSCFLQRE--ETLASSVAYCFTHLSLQEFVAAAYYY-------GASRRAIFD 477
GA S FL+ + ++Y F HL QEF AA Y G I D
Sbjct: 598 -----GAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIID 652
Query: 478 LFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQG 537
L ++ ++A + GL L G L +G
Sbjct: 653 L---------------------EKTLEAYG---------IHGLFGASTTRFLLGLLSDEG 682
Query: 538 EHQAYR------TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
E + +Q L+Q + ++ LHCL+E ++ V E
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMG 742
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD 651
+ T + ++ S L L + + P ++ + T D
Sbjct: 743 MCVET-DMELLVCTFCIKFS---RHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVT----D 794
Query: 652 PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS-LTSLDLRGNSIGPQG 710
++L SVL ++++ L+ N +S+ K+L ++L R L +L L G + +
Sbjct: 795 AYWQILFSVLK-VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQR 769
K LA L+ N+TLT L L N + D GA+ + + L + L L L + Q
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ-GLESLDLQSNSISDAGVAALMG 828
+A L + SLKEL N++ D G + L E L+ L L L ++SD L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 829 ALCTNQTLLSLSLRENSI 846
LL S R+ S+
Sbjct: 974 LEQEKPQLLIFSRRKPSV 991
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 690 LLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT-SLSLQGNTVRDDGARSMAEALAS 748
L V R+L LDL GNS+ K+L L+ R L +L L G + + + +A L +
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRA 863
Query: 749 NRTLSMLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQG 807
N+TL+ L L N + GA+ + L+Q + L+ L S + + LA L +
Sbjct: 864 NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPS 923
Query: 808 LESLDLQSNSISDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAI 854
L+ LDLQ N++ D GV L G L+ L L + ++S E Q +
Sbjct: 924 LKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSL 841
++F + D + L LKV + L+ LDL NS+S + V +L L + LL +L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWN 900
++ E + +A L AN TL LDL+ N+L D GA+ + +R+ + L L L
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943
+ + Q L L + SL LDLQ+N + D G + L+
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVL 966
Q L L++ R+L LDL N++ ++ + L+ L L L + A + L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 967 GEALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATA 1025
L N+TL LDL N + AGAK L L+ S L+RL L L D +A+
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTC 1061
LS + L+ ++LQ N++ D G R++ E ++ P C
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLR--HPAC 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
Q+L L V R L+ LDL GN++ + K+L L + L L L L + +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L N L ++L N + D+GA+ + + ++ P+C ++
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR--QPSCKLQ 897
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 128 bits (321), Expect = 3e-29
Identities = 170/694 (24%), Positives = 275/694 (39%), Gaps = 101/694 (14%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQV-GKDFSLVLPLTFRDLNTHEKLCADRLICS 196
PR+ I G AG+GK+TL R W GQ+ G F V + R+L A + S
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL-------AQSKVVS 379
Query: 197 VFPHVGEPSLAVAVPARALL--------ILDGLDECRTPLDFSNTVACTDPKKEIPVDHL 248
+ +G+ A P R +L ILDG+DE L ++ C + P D L
Sbjct: 380 LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADAL 439
Query: 249 ITNIIRGNLFPEVSIWITSRPSA-SGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPED-Q 306
+ +++ + PE S IT+R +A IP R E+ GF+E K + F ++ Q
Sbjct: 440 LGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQ 499
Query: 307 ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSW 366
A+ + L V++++ L+ +C VP L L + + + +T L
Sbjct: 500 AIRAFRL--VKSNKELWALCLVPWVSWLACTCLMQQMKRK----EKLTLTSKTTTTLCLH 553
Query: 367 YFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVD 426
Y AL + P++ L LA G+ +KK +F D++ G+D
Sbjct: 554 YLAQALQAQ-----PLGPQLRD-----------LCSLAAEGIWQKKTLFSPDDLRKHGLD 597
Query: 427 LALLQGAPCSCFLQRE--ETLASSVAYCFTHLSLQEFVAAAYYY-------GASRRAIFD 477
GA S FL+ + ++Y F HL QEF AA Y G I D
Sbjct: 598 -----GAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIID 652
Query: 478 LFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQG 537
L ++ ++A + GL L G L +G
Sbjct: 653 L---------------------EKTLEAYG---------IHGLFGASTTRFLLGLLSDEG 682
Query: 538 EHQAYR------TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
E + +Q L+Q + ++ LHCL+E ++ V E
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMG 742
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD 651
+ T + ++ S L L + + P ++ + T D
Sbjct: 743 MCVET-DMELLVCTFCIKFS---RHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVT----D 794
Query: 652 PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS-LTSLDLRGNSIGPQG 710
++L SVL ++++ L+ N +S+ K+L ++L R L +L L G + +
Sbjct: 795 AYWQILFSVLK-VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQR 769
K LA L+ N+TLT L L N + D GA+ + + L + L L L + Q
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALK 803
+A L + SLKEL N++ D G + L E L+
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSL 841
++F + D + L LKV + L+ LDL NS+S + V +L L + LL +L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWN 900
++ E + +A L AN TL LDL+ N+L D GA+ + +R+ + L L L
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943
+ + Q L L + SL LDLQ+N + D G + L+
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 67.0 bits (162), Expect = 9e-11
Identities = 47/143 (32%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 690 LLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT-SLSLQGNTVRDDGARSMAEALAS 748
L V R+L LDL GNS+ K+L L+ R L +L L G + + + +A L +
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRA 863
Query: 749 NRTLSMLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQG 807
N+TL+ L L N + GA+ + L+Q + L+ L S + + LA L +
Sbjct: 864 NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPS 923
Query: 808 LESLDLQSNSISDAGVAALMGAL 830
L+ LDLQ N++ D GV L L
Sbjct: 924 LKELDLQQNNLDDVGVRLLCEGL 946
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVL 966
Q L L++ R+L LDL N++ ++ + L+ L L L + A + L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 967 GEALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATA 1025
L N+TL LDL N + AGAK L L+ S L+RL L L D +A+
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTC 1061
LS + L+ ++LQ N++ D G R++ E ++ P C
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLR--HPAC 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
Q+L L V R L+ LDL GN++ + K+L L + L L L L + +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L N L ++L N + D+GA+ + + ++ P+C ++
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR--QPSCKLQ 897
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 128 bits (321), Expect = 3e-29
Identities = 170/694 (24%), Positives = 275/694 (39%), Gaps = 101/694 (14%)
Query: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQV-GKDFSLVLPLTFRDLNTHEKLCADRLICS 196
PR+ I G AG+GK+TL R W GQ+ G F V + R+L A + S
Sbjct: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL-------AQSKVVS 379
Query: 197 VFPHVGEPSLAVAVPARALL--------ILDGLDECRTPLDFSNTVACTDPKKEIPVDHL 248
+ +G+ A P R +L ILDG+DE L ++ C + P D L
Sbjct: 380 LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADAL 439
Query: 249 ITNIIRGNLFPEVSIWITSRPSA-SGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPED-Q 306
+ +++ + PE S IT+R +A IP R E+ GF+E K + F ++ Q
Sbjct: 440 LGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQ 499
Query: 307 ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSW 366
A+ + L V++++ L+ +C VP L L + + + +T L
Sbjct: 500 AIRAFRL--VKSNKELWALCLVPWVSWLACTCLMQQMKRK----EKLTLTSKTTTTLCLH 553
Query: 367 YFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVD 426
Y AL + P++ L LA G+ +KK +F D++ G+D
Sbjct: 554 YLAQALQAQ-----PLGPQLRD-----------LCSLAAEGIWQKKTLFSPDDLRKHGLD 597
Query: 427 LALLQGAPCSCFLQRE--ETLASSVAYCFTHLSLQEFVAAAYYY-------GASRRAIFD 477
GA S FL+ + ++Y F HL QEF AA Y G I D
Sbjct: 598 -----GAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIID 652
Query: 478 LFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQG 537
L ++ ++A + GL L G L +G
Sbjct: 653 L---------------------EKTLEAYG---------IHGLFGASTTRFLLGLLSDEG 682
Query: 538 EHQAYR------TQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGA 591
E + +Q L+Q + ++ LHCL+E ++ V E
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMG 742
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD 651
+ T + ++ S L L + + P ++ + T D
Sbjct: 743 MCVET-DMELLVCTFCIKFS---RHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVT----D 794
Query: 652 PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRS-LTSLDLRGNSIGPQG 710
++L SVL ++++ L+ N +S+ K+L ++L R L +L L G + +
Sbjct: 795 AYWQILFSVLK-VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQR 769
K LA L+ N+TLT L L N + D GA+ + + L + L L L + Q
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALK 803
+A L + SLKEL N++ D G + L E L+
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSL 841
++F + D + L LKV + L+ LDL NS+S + V +L L + LL +L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 842 RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSLHLQWN 900
++ E + +A L AN TL LDL+ N+L D GA+ + +R+ + L L L
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 901 FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943
+ + Q L L + SL LDLQ+N + D G + L+
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
Score = 67.0 bits (162), Expect = 9e-11
Identities = 47/143 (32%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 690 LLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT-SLSLQGNTVRDDGARSMAEALAS 748
L V R+L LDL GNS+ K+L L+ R L +L L G + + + +A L +
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRA 863
Query: 749 NRTLSMLHLQKNSIGPMGAQRMADALKQ-NRSLKELMFSSNSIGDGGAKALAEALKVNQG 807
N+TL+ L L N + GA+ + L+Q + L+ L S + + LA L +
Sbjct: 864 NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPS 923
Query: 808 LESLDLQSNSISDAGVAALMGAL 830
L+ LDLQ N++ D GV L L
Sbjct: 924 LKELDLQQNNLDDVGVRLLCEGL 946
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVL 966
Q L L++ R+L LDL N++ ++ + L+ L L L + A + L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 967 GEALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATA 1025
L N+TL LDL N + AGAK L L+ S L+RL L L D +A+
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTC 1061
LS + L+ ++LQ N++ D G R++ E ++ P C
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLR--HPAC 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
Q+L L V R L+ LDL GN++ + K+L L + L L L L + +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L N L ++L N + D+GA+ + + ++ P+C ++
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR--QPSCKLQ 897
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 128 bits (321), Expect = 3e-29
Identities = 218/917 (23%), Positives = 369/917 (40%), Gaps = 119/917 (12%)
Query: 128 FLPLSRVSVP----PRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLN 183
F+P P P + G AG+GKTTL + + W + L+ ++L+
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELS 216
Query: 184 THEKLCADRLICSVFPHVGE--PSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKK 241
LI +P + + PS+ +A R L ++DGLDE + P C D +K
Sbjct: 217 RMGPCSFAELISKDWPELQDDIPSI-LAQAQRILFVVDGLDELKVPPGALIQDICGDWEK 275
Query: 242 EIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRM---TEIRGFNEEEIKVCL 298
+ PV L+ ++++ + P ++ +T+RP A + L+ + + GF EE+ +
Sbjct: 276 KKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ--LLAQQPIYVRVEGFLEEDRRAYF 333
Query: 299 EQMF-PEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPP 357
+ F EDQA+ + L ++++ AL+ + + PA C + L + + E P
Sbjct: 334 LRHFGDEDQAMRAFEL--MRSNAALFQLGSAPAVCWIVCTTL------KLQMEKGE--DP 383
Query: 358 RTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYE 417
C + F L + + R + TL LA GL + VF+
Sbjct: 384 VPTCLTRTGLFLRFLCSRFPQGAQL-----------RGALRTLSLLAAQGLWAQMSVFHR 432
Query: 418 QDMKAFGVDLALLQGAPCSCFLQRE---ETLASSVAYCFTHLSLQEFVAAAYYYGASRRA 474
+D++ GV Q + FL + + S Y F HLS Q+F+ A +Y
Sbjct: 433 EDLERLGV-----QESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEG 487
Query: 475 IFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLL 534
G +W +G + S +R + L FL GL N A L
Sbjct: 488 ----EDRDGHAWD-IGDVQKLLSGEERLKNPD---LIQVGHFLFGL----ANEKRAKELE 535
Query: 535 AQGEHQAYRTQVAELLQ--GCLRPDAAVCARAI-NVLHCLHELQHTELARSVEEAMESGA 591
A + ELLQ L + + + VL CL+E Q ELA+ V + +
Sbjct: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEIS 595
Query: 592 LARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGV----------------------- 628
+ LT + ++ L+ C LSL +++GV
Sbjct: 596 I-HLTNTSEVMHCSFSLK---HCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIP 651
Query: 629 ------LQSLLPQLLYC---------RKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISL 673
L+SL +C + L + + D + +L ++ C +QK+ +
Sbjct: 652 NWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEI 711
Query: 674 AENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAK-ALADALKINR-TLTSLSLQG 731
+N + + + + ++LT L L G+ + L D L+ ++ L L L G
Sbjct: 712 -KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 770
Query: 732 NTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSN-SI 790
+ + L +N++L L L N + GA + + + + +++ N +
Sbjct: 771 HCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRL 830
Query: 791 GDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL----CTNQTLLSLSLRENSI 846
+ K LA L V++ L L L N I D GV L L C QTL+ L++ SI
Sbjct: 831 TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLV---LQQCSI 887
Query: 847 SPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR--ENRTLTSLHLQ-WN-FI 902
+ G + ++ AL +L NLDL+ N Q AR + + + EN HL+ W+ +
Sbjct: 888 TKLGCRYLSEALQEACSLTNLDLSIN----QIARGLWILCQALENPNCNLKHLRLWSCSL 943
Query: 903 QAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT-ALTALYLQVASIGAS 961
Q LG AL N+ L +LDL +N + G + L+ T +L L L+
Sbjct: 944 MPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLE 1003
Query: 962 GAQVLGEALAVNRTLEI 978
++L E N L I
Sbjct: 1004 IKKLLEEVKEKNPKLTI 1020
Score = 75.9 bits (185), Expect = 2e-13
Identities = 83/305 (27%), Positives = 134/305 (43%), Gaps = 6/305 (1%)
Query: 747 ASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806
+SN L L ++++ + + + D + ++ + + N D + A +
Sbjct: 672 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKK 731
Query: 807 GLESLDLQSNSISDAGVAALMGALCTNQ--TLLSLSLRENSISPEGAQAIAHALCANSTL 864
L L L + + + ++ L N L L L + +PE + L AN +L
Sbjct: 732 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 791
Query: 865 KNLDLTANLLHDQGARAI-AVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSL 923
K+L L+AN+L D+GA + R L L L+ + + + L L +++ LT L
Sbjct: 792 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 851
Query: 924 DLQENAIGDDGACAVARALKV-NTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLR 982
L +N IGD G + L + L L LQ SI G + L EAL +L LDL
Sbjct: 852 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 911
Query: 983 GNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNH 1041
N I G L AL+ N +L+ L L SL + +AL N +L+ ++L NH
Sbjct: 912 INQI-ARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNH 970
Query: 1042 IGDSG 1046
+ SG
Sbjct: 971 LWKSG 975
Score = 37.7 bits (86), Expect = 0.058
Identities = 51/212 (24%), Positives = 89/212 (41%), Gaps = 13/212 (6%)
Query: 860 ANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQW----NFIQAGAAQALGQALQ 915
+NS LK L++ + L D R + ++ T ++ HLQ N A + A
Sbjct: 673 SNSNLKFLEVKQSFLSDSSVRILC----DHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI 728
Query: 916 LNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQ--VLGEALAVN 973
++LT L L + + + L N YL++ A+ Q L N
Sbjct: 729 GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKAN 788
Query: 974 RTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICIATALSGNHRL 1032
++L+ L L N + GA L + + L+ L+L+ L +A L + +L
Sbjct: 789 QSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL 848
Query: 1033 QHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
H+ L N IGD+G + + E + + P C ++
Sbjct: 849 THLCLAKNPIGDTGVKFLCEGL--SYPDCKLQ 878
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 124 bits (310), Expect = 6e-28
Identities = 191/827 (23%), Positives = 333/827 (40%), Gaps = 70/827 (8%)
Query: 145 GVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTFRDLNTHEKLCADRLICSVFPHVGE 203
G G+GKTTL+R + WA G + KD F+ V L ++N + L+ +P E
Sbjct: 152 GPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSE 211
Query: 204 PSLAV-AVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVS 262
+ + P R L I+DG ++ + L ++ D ++ P+ +++++++ + PE S
Sbjct: 212 KIEDIFSQPERILFIMDGFEQLKFNLQLKADLS-DDWRQRQPMPIILSSLLQKKMLPESS 270
Query: 263 IWITSRPSASGQIPGGL-VDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRA 321
+ I A + L ++ ++ GF+E E K F E L + + V+ +
Sbjct: 271 LLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALK-VFNFVRDNGP 329
Query: 322 LYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGK 381
L+++C P C L + R G +D E+ T LY+ + Q
Sbjct: 330 LFILCHNPFTCWLVCTCVKQ--RLERG-EDLEINSQNT-TYLYASFLTTVFKAGSQ---S 382
Query: 382 ASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQR 441
P++ R + +L LA G+ +VF D++ G+ + LQR
Sbjct: 383 FPPKV------NRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR 436
Query: 442 EETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQR 501
+ F HL +QEF AA +Y L P +G +T A+
Sbjct: 437 R-----GDCFAFMHLCIQEFCAAMFYL---------LKRPKDDPNPAIGSITQLVRASVV 482
Query: 502 AMQAEDGRLDVFLRFLSGLLSPRVNALLAGSL---LAQGEHQAYRTQVAELLQGCLRPDA 558
Q ++ + F+ G+ + + ++L S L++ Q TQ E L C
Sbjct: 483 QPQTLLTQVGI---FMFGISTEEIVSMLETSFGFPLSKDLKQEI-TQCLESLSQCEADRE 538
Query: 559 AVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEA 618
A+ + + + L E Q E V E + H ++ L+ C
Sbjct: 539 AIAFQELFI--GLFETQEKEFVTKVMNFFEE-VFIYIGNIEHLVIASFCLK---HCQHLT 592
Query: 619 NLSLSL------SQGVLQSLLPQLLYCRK-------------LRLDTNQFQDPVMELLGS 659
L + + G + +L+Y R+ L ++ DP + +L
Sbjct: 593 TLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCK 652
Query: 660 VLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK 719
L+ C+++K+ + L +++L N L L L G S+ + L + LK
Sbjct: 653 ALAQPVCKLRKLIFTSVYFGHD--SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLK 710
Query: 720 INR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR 778
+ L L + + +A LA N L L L +N + G + +ALK +
Sbjct: 711 HPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSH 770
Query: 779 -SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL-CTNQTL 836
+L+ LM + +++E L ++ L LDL SN++ D GVA+L AL ++
Sbjct: 771 CALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSI 830
Query: 837 LSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE-NRTLTSL 895
L L ++ + + IA L N LK L L N + D G R + A++ + L L
Sbjct: 831 RELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECL 890
Query: 896 HLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL 942
LQ I + AL ++L SL+L A+ D + AL
Sbjct: 891 GLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEAL 937
Score = 89.0 bits (219), Expect = 2e-17
Identities = 88/334 (26%), Positives = 151/334 (45%), Gaps = 15/334 (4%)
Query: 740 RSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKAL 798
R + +N+ +L ++ S+ + AL Q L++L+F+S G L
Sbjct: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSE--L 677
Query: 799 AEALKVNQGLESLDLQSNSISDAGVAALMGAL----CTNQTLLSLSLRENSISPEGAQAI 854
+A+ N L+ L L S+S + + L L C + L+ L + IS E + I
Sbjct: 678 FKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELI---LGKCDISSEVCEDI 734
Query: 855 AHALCANSTLKNLDLTANLLHDQGARAIAVAVRENR-TLTSLHLQWNFIQAGAAQALGQA 913
A L NS LK+L L N L D+G + A++ + L L L + + + + ++ +
Sbjct: 735 ASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEV 794
Query: 914 LQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVLGEALAV 972
L ++SL+ LDL NA+ D+G ++ ALK ++ L+L + + + + L
Sbjct: 795 LLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLIC 854
Query: 973 NRTLEILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSGNHR 1031
N L+ L L N IG G + L AL+ + L L LQ + IA AL
Sbjct: 855 NGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKT 914
Query: 1032 LQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065
L+ +NL + ++ EA+ + P C ++M
Sbjct: 915 LRSLNLDWIALDADAVVVLCEAL--SHPDCALQM 946
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 122 bits (306), Expect = 2e-27
Identities = 217/920 (23%), Positives = 361/920 (39%), Gaps = 125/920 (13%)
Query: 126 RLFLPLSRVSV-PPRVSITI---GVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRD 181
++ +P S V P S T+ G AG+GKTTL + + WA + F L+ R+
Sbjct: 190 KMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRE 249
Query: 182 LNTHEKLCADRLICSVFPHVGEPSLAVAVPARALL-ILDGLDECRTPLDFSNTVACTDPK 240
L+ L+ +P + + + AR +L ++DG DE C D +
Sbjct: 250 LSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWE 309
Query: 241 KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIR--GFNEEEIKVCL 298
K+ PV L+ +++ + P+ ++ +T+RP A + L + IR GF EE+ +
Sbjct: 310 KKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRI-LAEEPIYIRVEGFLEEDRRAYF 368
Query: 299 EQMF-PEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPP 357
+ F EDQA+ + L ++++ AL+ + + PA C + L P L
Sbjct: 369 LRHFGDEDQAMRAFEL--MRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 426
Query: 358 ----RTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKY 413
R LC + P+ Q+ R + TL LA GL +
Sbjct: 427 GLFLRFLCSRF-------------------PQGAQL----RGALRTLSLLAAQGLWAQTS 463
Query: 414 VFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRR 473
V + +D++ GV + L+ L+++ S Y F HLS Q+F+ A +Y
Sbjct: 464 VLHREDLERLGVQESDLRLFLDGDILRQDRV--SKGCYSFIHLSFQQFLTALFYTLEKEE 521
Query: 474 AIFDLFTESGVSWPRLGFLTHFRSAAQRAMQ-------------AEDGRLDVFLRFLSGL 520
G +W +G + S +R A + R
Sbjct: 522 EE----DRDGHTWD-IGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCR 576
Query: 521 LSPRVNA-LLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTEL 579
+SP + LL + +G H T + ELL CL+E Q EL
Sbjct: 577 MSPDIKQELLRCDISCKGGHSTV-TDLQELLG------------------CLYESQEEEL 617
Query: 580 ARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYC 639
+ V + +L H A+ + S C + +S V++ LP+ +
Sbjct: 618 VKEVMAQFKEISL-------HLNAVDVV--PSSFCVKHCRNLQKMSLQVIKENLPENVTA 668
Query: 640 RKLRLDTNQFQD-----PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNR 694
+ + + QD P L S+ G + + +++ ++ +S + L + +
Sbjct: 669 SESDAEVERSQDDQHMLPFWTDLCSIF-GSNKDLMGLAINDSFLSASLVRILCEQIASDT 727
Query: 695 SLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSM 754
+ N + L AL+ ++T+T L+LQGN +DD ++ E L
Sbjct: 728 CHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLR------- 779
Query: 755 LHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQ 814
H + N L+ L S S L+ AL+VNQ L ++L
Sbjct: 780 -HPECN-------------------LRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLS 819
Query: 815 SNSISDAGVAALMGALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANL 873
N + D G L L + L LSL ++ + +A L + L +L L N
Sbjct: 820 DNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNP 879
Query: 874 LHDQGARAIAVAVRENRTLTSLHLQWNF-IQAGAAQALGQALQLNRSLTSLDLQENAIGD 932
+ + G + + +R + WN I + L + LQ SL LDL N IG
Sbjct: 880 IGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGV 939
Query: 933 DGACAVARALKVNTA-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGA 991
G + AL+ L L+L SI + L AL+ N++L LDL N +G +G
Sbjct: 940 KGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGV 999
Query: 992 KALANALKVNS-SLRRLNLQ 1010
K L L +S +LR L L+
Sbjct: 1000 KMLFETLTCSSGTLRTLRLK 1019
Score = 62.0 bits (149), Expect = 3e-09
Identities = 62/262 (23%), Positives = 111/262 (42%), Gaps = 32/262 (12%)
Query: 832 TNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRT 891
+N+ L+ L++ ++ +S + + + +++ + N+ R + +A+R ++T
Sbjct: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756
Query: 892 LTSLHLQWN------------------------FIQAGAAQA----LGQALQLNRSLTSL 923
+T L LQ N + A L AL++N+SLT +
Sbjct: 757 VTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCV 816
Query: 924 DLQENAIGDDGACAVARALK-VNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLR 982
+L +N + D+GA + L+ L L L+ + + + L L V+R L L L
Sbjct: 817 NLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLA 876
Query: 983 GNAIGVAGAKALANALKV-NSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNH 1041
N IG G K L L+ L+ L L + DG + L L ++L NH
Sbjct: 877 KNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNH 936
Query: 1042 IGDSGARMISEAIKTNAPTCTV 1063
IG G + + EA++ P C +
Sbjct: 937 IGVKGMKFLCEALR--KPLCNL 956
Score = 53.5 bits (127), Expect = 1e-06
Identities = 61/232 (26%), Positives = 96/232 (41%), Gaps = 14/232 (6%)
Query: 582 SVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRK 641
S E ++ GA T H L + + EAN + L L+ R+
Sbjct: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANC---------KDLAAVLVVSRE 869
Query: 642 LR---LDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTS 698
L L N + ++ L L +C++Q + L I++ G L + L SL
Sbjct: 870 LTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLC 929
Query: 699 LDLRGNSIGPQGAKALADAL-KINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHL 757
LDL N IG +G K L +AL K L L L G ++ + AL+ N++L L L
Sbjct: 930 LDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDL 989
Query: 758 QKNSIGPMGAQRMADALK-QNRSLKELMFSSNSIGDGGAKALAEALKVNQGL 808
+N +G G + + + L + +L+ L + D K L E + N L
Sbjct: 990 GQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
Score = 50.8 bits (120), Expect = 7e-06
Identities = 61/209 (29%), Positives = 94/209 (44%), Gaps = 16/209 (7%)
Query: 866 NLDLTANLLHDQGARAIAVAVR-ENRTLTSLHLQW----NFIQAGAAQALGQALQLNRSL 920
N DL ++D A V + E + HLQ N A A + L AL+ ++++
Sbjct: 698 NKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTV 757
Query: 921 TSLDLQENAIGD--DGACAVARALKVNTALTALYLQVASIGASGAQV--LGEALAVNRTL 976
T L LQ N D C V R + N YL + S A+ Q L AL VN++L
Sbjct: 758 TYLTLQGNDQDDMFPALCEVLRHPECNLR----YLGLVSCSATTQQWADLSLALEVNQSL 813
Query: 977 EILDLRGNAIGVAGAKALANALK-VNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHI 1035
++L N + GAK L L+ L+RL+L+ L +A L + L H+
Sbjct: 814 TCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHL 873
Query: 1036 NLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
L N IG++G + + E ++ P C ++
Sbjct: 874 CLAKNPIGNTGVKFLCEGLR--YPECKLQ 900
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 121 bits (303), Expect = 4e-27
Identities = 104/402 (25%), Positives = 182/402 (45%), Gaps = 8/402 (1%)
Query: 669 QKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI-NRTLTSL 727
Q + L + ++ K ++ +L VN +L L+LR N +G G + L+ + + L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFS 786
SLQ + G ++ L + TL LHL N +G G Q + + L + L++L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENS 845
S+ + LA L+ + L + +N I++AGV L L + L +L L
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 846 ISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQA 904
++ + + + + + ++L+ L L +N L D G + + + L +L + I A
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 905 GAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARAL-KVNTALTALYLQVASIGASGA 963
L + L+ SL L L N +GD+GA + L + L +L+++ S A+
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 964 QVLGEALAVNRTLEILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICI 1022
LA NR L L + N + AG + L L + S LR L L + + +
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 1023 ATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
A L NH L+ ++L N +GD+G + E+++ P C +E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVR--QPGCLLE 430
Score = 106 bits (264), Expect = 1e-22
Identities = 95/364 (26%), Positives = 151/364 (41%), Gaps = 5/364 (1%)
Query: 641 KLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
+L L +N+ D + + L C+IQK+SL ++ G L+ +L +L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 701 LRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQK 759
L N +G G + L + L + L L L+ ++ +A L + L +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 760 NSIGPMGAQRMADALKQNR-SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
N I G + + LK + L+ L S + + L + L L L SN +
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 819 SDAGVAALM-GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
D G+A L G L + L +L + E I+ +G + L A +LK L L N L D+
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 878 GARAIAVAVRE-NRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGAC 936
GAR + + E L SL ++ A L NR L L + N + D G
Sbjct: 300 GARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Query: 937 AVARAL-KVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALA 995
+ + L + + L L+L + S L L N +L LDL N +G AG L
Sbjct: 360 ELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLV 419
Query: 996 NALK 999
+++
Sbjct: 420 ESVR 423
Score = 97.1 bits (240), Expect = 8e-20
Identities = 86/321 (26%), Positives = 128/321 (39%), Gaps = 4/321 (1%)
Query: 627 GVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKAL 686
GVL S L L ++L L N D ++LL L CR++K+ L +S + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 687 ARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNTVRDDGARSMAEA 745
A L L + N I G + L LK + L +L L+ V D R +
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKV 804
+AS +L L L N +G +G + L S L+ L I G L L+
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 805 NQGLESLDLQSNSISDAGVAALMGALC-TNQTLLSLSLRENSISPEGAQAIAHALCANST 863
+ L+ L L N + D G L L L SL ++ S + + L N
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 864 LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTS 922
L L ++ N L D G R + + + L L L + + +L L N SL
Sbjct: 343 LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRE 402
Query: 923 LDLQENAIGDDGACAVARALK 943
LDL N +GD G + +++
Sbjct: 403 LDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 6/300 (2%)
Query: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMG 828
R A+ L + + + + + K ++ AL+VN L L+L+SN + D GV ++
Sbjct: 19 RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQ 78
Query: 829 ALCTNQTLLS-LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVR 887
L T + LSL+ ++ G ++ L TL+ L L+ NLL D G + + +
Sbjct: 79 GLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLL 138
Query: 888 ENRT-LTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
+ + L L L++ + A + + L L+ L + N I + G + + LK +
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 947 A-LTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAG-AKALANALKVNSSL 1004
L AL L+ + + + L +A +L L L N +G G A+ L +S L
Sbjct: 199 CQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 1005 RRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVE 1064
R L + E + G + L L+ ++L GN +GD GAR++ E + P C +E
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL--EPGCQLE 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,034,739
Number of Sequences: 37866
Number of extensions: 1608866
Number of successful extensions: 5276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 3887
Number of HSP's gapped (non-prelim): 537
length of query: 1065
length of database: 18,247,518
effective HSP length: 113
effective length of query: 952
effective length of database: 13,968,660
effective search space: 13298164320
effective search space used: 13298164320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.