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Search of human proteins with 118402582
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118402582 cell division cycle 20 [Homo sapiens]
(499 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118402582 cell division cycle 20 [Homo sapiens] 1023 0.0
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 325 4e-89
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 325 6e-89
gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho... 306 2e-83
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 258 1e-68
gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H... 233 2e-61
gi|16554629 WD repeat domain 5 [Homo sapiens] 100 2e-21
gi|16554627 WD repeat domain 5 [Homo sapiens] 100 2e-21
gi|21071067 TBP-associated factor 5 [Homo sapiens] 96 1e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 94 3e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 92 1e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 7e-18
gi|113865883 WD repeat domain 38 [Homo sapiens] 85 1e-16
gi|19913367 transducin beta-like 1Y [Homo sapiens] 82 1e-15
gi|19913365 transducin beta-like 1Y [Homo sapiens] 82 1e-15
gi|15150805 transducin beta-like 1Y [Homo sapiens] 82 1e-15
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 82 1e-15
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 81 3e-15
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 79 7e-15
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 79 7e-15
gi|4757988 WD repeat domain 39 [Homo sapiens] 79 7e-15
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 1e-14
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 79 1e-14
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 78 2e-14
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 78 2e-14
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 78 2e-14
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 76 6e-14
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 76 6e-14
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 76 6e-14
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 76 6e-14
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 1023 bits (2646), Expect = 0.0
Identities = 499/499 (100%), Positives = 499/499 (100%)
Query: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP
Sbjct: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60
Query: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120
GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL
Sbjct: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120
Query: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180
NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE
Sbjct: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180
Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240
IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY
Sbjct: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240
Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300
LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH
Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300
Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360
HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA
Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360
Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420
VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF
Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420
Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480
AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR
Sbjct: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480
Query: 481 REREKASAAKSSLIHQGIR 499
REREKASAAKSSLIHQGIR
Sbjct: 481 REREKASAAKSSLIHQGIR 499
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 325 bits (834), Expect = 4e-89
Identities = 189/471 (40%), Positives = 266/471 (56%), Gaps = 53/471 (11%)
Query: 58 RTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWA 117
RT +SS V ++PSK G DR+IP R+ A V +F EN+ SQ K+ A
Sbjct: 29 RTLTPASSPV-SSPSKHG-DRFIPSRAGANWSV-NFHRINENEKSPSQNRKAKD-----A 80
Query: 118 LNLNGFD------VEEAKILRLSGKPQNAPEGYQNRLKV------------LYSQKATPG 159
+ NG D + + ++L + P+ RL+ L +++++P
Sbjct: 81 TSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPD 140
Query: 160 ----------------------SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNV 197
S RK R I +P ++LDAPE+++D+YLNLVDWSS NV
Sbjct: 141 DGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNV 200
Query: 198 LAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257
L+V L VYLWSA + + +L + G+ ++SV W + GN +AVGT VQ+WD
Sbjct: 201 LSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAA 260
Query: 258 QKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLR 316
K+L + H+ARVG+L+WN+ LSSGSR I D+R L GH QEVCGL+
Sbjct: 261 GKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 320
Query: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376
W+ D + LASGGNDN + VW P+Q +T+H AVKA+AW P Q +LA+GGG
Sbjct: 321 WSTDHQLLASGGNDNKLLVW----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGG 376
Query: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436
T+DR IR WN +G L +D SQVC++ WS H EL+S HG++QNQ+++WKYP++ +V
Sbjct: 377 TADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQV 436
Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKAS 487
A+L GH+ RVL L MSPDG + + A DETLR W F + + + E S
Sbjct: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVS 487
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 325 bits (833), Expect = 6e-89
Identities = 187/457 (40%), Positives = 261/457 (57%), Gaps = 53/457 (11%)
Query: 58 RTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWA 117
RT +SS V ++PSK G DR+IP R+ A V +F EN+ SQ K+ A
Sbjct: 29 RTLTPASSPV-SSPSKHG-DRFIPSRAGANWSV-NFHRINENEKSPSQNRKAKD-----A 80
Query: 118 LNLNGFD------VEEAKILRLSGKPQNAPEGYQNRLKV------------LYSQKATPG 159
+ NG D + + ++L + P+ RL+ L +++++P
Sbjct: 81 TSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPD 140
Query: 160 ----------------------SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNV 197
S RK R I +P ++LDAPE+++D+YLNLVDWSS NV
Sbjct: 141 DGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNV 200
Query: 198 LAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257
L+V L VYLWSA + + +L + G+ ++SV W + GN +AVGT VQ+WD
Sbjct: 201 LSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAA 260
Query: 258 QKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLR 316
K+L + H+ARVG+L+WN+ LSSGSR I D+R L GH QEVCGL+
Sbjct: 261 GKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 320
Query: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376
W+ D + LASGGNDN + VW P+Q +T+H AVKA+AW P Q +LA+GGG
Sbjct: 321 WSTDHQLLASGGNDNKLLVW----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGG 376
Query: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436
T+DR IR WN +G L +D SQVC++ WS H EL+S HG++QNQ+++WKYP++ +V
Sbjct: 377 TADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQV 436
Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473
A+L GH+ RVL L MSPDG + + A DETLR W F
Sbjct: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELI 415
+V +V W + N++A G T ++IW+ +G LS ++ H+ +V ++ W+ ++L
Sbjct: 231 SVTSVGWSE-RGNLVAVG--THKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLS 285
Query: 416 SGHGFAQNQLVIWK---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
SG +++++++ + P + L+GH V L S D +AS D L +W
Sbjct: 286 SG---SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342
Query: 473 FELDPARR 480
L P ++
Sbjct: 343 SSLSPVQQ 350
>gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo
sapiens]
Length = 515
Score = 306 bits (785), Expect = 2e-83
Identities = 147/294 (50%), Positives = 199/294 (67%), Gaps = 7/294 (2%)
Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240
+RNDYYLN++DWS N++A+AL ++VY+W+ + + ++ + + YISSV+WIKEG
Sbjct: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300
LAVGTS EVQLWDV +KRLRNM H + VG+LSWN +ILSSGSR G ++HHDVRVA+H
Sbjct: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQH 347
Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG-WVPLQTFTQHQGAVK 359
HV TL H Q VC L+W+PDGR L+SG +D L+ +WP PG PL+ TQ AVK
Sbjct: 348 HVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQ-STAVK 405
Query: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419
A+ WCPWQS VLA GGG D + I ++ +G + +SQ+CS++W P KE+ +G G
Sbjct: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473
+N + +W PT+++ GH RVL L +SPD V SAAAD T +W C+
Sbjct: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 258 bits (658), Expect = 1e-68
Identities = 123/259 (47%), Positives = 167/259 (64%), Gaps = 5/259 (1%)
Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275
+ +L + G+ ++SV W + GN +AVGT VQ+WD K+L + H+ARVG+L+
Sbjct: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
Query: 276 WNSYILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
WN+ LSSGSR I D+R L GH QEVCGL+W+ D + LASGGNDN +
Sbjct: 190 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394
VW P+Q +T+H AVKA+AW P Q +LA+GGGT+DR IR WN +G L
Sbjct: 250 VW----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQ 305
Query: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454
+D SQVC++ WS H EL+S HG++QNQ+++WKYP++ +VA+L GH+ RVL L MSPD
Sbjct: 306 CIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPD 365
Query: 455 GATVASAAADETLRLWRCF 473
G + + A DETLR W F
Sbjct: 366 GEAIVTGAGDETLRFWNVF 384
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELI 415
+V +V W + N++A G T ++IW+ +G LS ++ H+ +V ++ W+ ++L
Sbjct: 142 SVTSVGWSE-RGNLVAVG--THKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLS 196
Query: 416 SGHGFAQNQLVIWK---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
SG +++++++ + P + L+GH V L S D +AS D L +W
Sbjct: 197 SG---SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 253
Query: 473 FELDPARR 480
L P ++
Sbjct: 254 SSLSPVQQ 261
>gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo
sapiens]
Length = 477
Score = 233 bits (595), Expect = 2e-61
Identities = 124/295 (42%), Positives = 169/295 (57%), Gaps = 47/295 (15%)
Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240
+RNDYYLN++DWS N++A+AL ++VY+W+ + + ++ + + YISSV+WIKEG
Sbjct: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300
LAVGTS EVQLWDV +KRLRNM H + VG+LSWN +ILSSGSR G ++HHDVRVA+H
Sbjct: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQH 347
Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG-WVPLQTFTQHQGA-V 358
HV TL H Q VC L+W+PDGR L+SG +D L+ +WP PG PL+ TQ +
Sbjct: 348 HVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKI 406
Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGH 418
++ W P ++ +ATG GT + +W
Sbjct: 407 CSLIWLP-KTKEIATGQGTPKNDVTVWTC------------------------------- 434
Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473
PT+++ GH RVL L +SPD V SAAAD T +W C+
Sbjct: 435 ------------PTVSRSGGFFGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 477
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 100 bits (250), Expect = 2e-21
Identities = 89/326 (27%), Positives = 144/326 (44%), Gaps = 23/326 (7%)
Query: 157 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSG 214
TP SS + P P+ L + ++ V +S +G LA + D + +W A G
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77
Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274
+ + + G IS VAW + N L + +++WDV K L+ + HS V
Sbjct: 78 KFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 275 SWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332
++N S ++ SGS + DV+ + + TL HS V + + DG + S D L
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 333 VNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391
+W +A G+ L+T V V + P +LA T D +++W+ G
Sbjct: 195 CRIWDTASGQ----CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGK 247
Query: 392 CLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447
CL H +++ K ++SG N + IW T V +L+GHT V+
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Query: 448 SLTMSPDGATVASAAA--DETLRLWR 471
S P +ASAA D+T++LW+
Sbjct: 306 STACHPTENIIASAALENDKTIKLWK 331
Score = 37.7 bits (86), Expect = 0.024
Identities = 16/44 (36%), Positives = 27/44 (61%)
Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
P A L GHT V S+ SP+G +AS++AD+ +++W ++
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 100 bits (250), Expect = 2e-21
Identities = 89/326 (27%), Positives = 144/326 (44%), Gaps = 23/326 (7%)
Query: 157 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSG 214
TP SS + P P+ L + ++ V +S +G LA + D + +W A G
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77
Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274
+ + + G IS VAW + N L + +++WDV K L+ + HS V
Sbjct: 78 KFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 275 SWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332
++N S ++ SGS + DV+ + + TL HS V + + DG + S D L
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 333 VNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391
+W +A G+ L+T V V + P +LA T D +++W+ G
Sbjct: 195 CRIWDTASGQ----CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGK 247
Query: 392 CLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447
CL H +++ K ++SG N + IW T V +L+GHT V+
Sbjct: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Query: 448 SLTMSPDGATVASAAA--DETLRLWR 471
S P +ASAA D+T++LW+
Sbjct: 306 STACHPTENIIASAALENDKTIKLWK 331
Score = 37.7 bits (86), Expect = 0.024
Identities = 16/44 (36%), Positives = 27/44 (61%)
Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
P A L GHT V S+ SP+G +AS++AD+ +++W ++
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 95.5 bits (236), Expect = 1e-19
Identities = 68/224 (30%), Positives = 113/224 (50%), Gaps = 15/224 (6%)
Query: 251 QLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
++ D + L+ + HS V S++ +Y+LSS S G + ++ V G
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFTCLVG-YKG 583
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367
H+ V +++P G + SGG+D + +W + + PL+ F H V + P
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWAT----DHYQPLRIFAGHLADVNCTRFHP-N 638
Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLV 426
SN +ATG ++DR +R+W+V +G C+ H + S+ +SP+ + L +G +++
Sbjct: 639 SNYVATG--SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA--TDGRVL 694
Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
+W V ELKGHT V SL S DG +AS + D T+RLW
Sbjct: 695 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 3/100 (3%)
Query: 239 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR 296
NY+A G++ V+LWDV +R T H + SL++ N L++G+ G + D+
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336
V L GH+ VC LR++ DG LASG DN V +W
Sbjct: 700 HG-LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 31.6 bits (70), Expect = 1.8
Identities = 25/96 (26%), Positives = 38/96 (39%), Gaps = 12/96 (12%)
Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434
GG +D +R+W+V S A S E I T +
Sbjct: 487 GGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDE------------KTAS 534
Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
++ L GH+ V + SPD + S++ D T+RLW
Sbjct: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/322 (26%), Positives = 142/322 (44%), Gaps = 23/322 (7%)
Query: 160 SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDIL 217
SS + +P P+ L + + ++ V +S +G LA + D + +W A G
Sbjct: 17 SSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE 76
Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN 277
+ L IS VAW + + L + ++LWDV+ K L+ + HS V ++N
Sbjct: 77 KTLYGHNLE--ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN 134
Query: 278 --SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNV 335
S ++ SGS + +V+ + + TLS HS V + + G + SG D L +
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGK-CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRI 193
Query: 336 WPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394
W +A G+ L+T V V + P +L T D +++W+ G CL
Sbjct: 194 WDAASGQ----CLKTLVDDDNPPVSFVKFSPNGKYILT---ATLDNTLKLWDYSRGRCLK 246
Query: 395 AVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450
H +++ K ++SG N + IW T V +L+GHT V+S
Sbjct: 247 TYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVISAA 304
Query: 451 MSPDGATVASAAA--DETLRLW 470
P +ASAA D+T++LW
Sbjct: 305 CHPTENLIASAALENDKTIKLW 326
Score = 35.8 bits (81), Expect = 0.093
Identities = 16/44 (36%), Positives = 25/44 (56%)
Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
P A L GHT V S+ SP+G +AS++AD + +W ++
Sbjct: 29 PNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/230 (31%), Positives = 114/230 (49%), Gaps = 16/230 (6%)
Query: 193 SSGNVLAVALDNS-VYLWSASSGD-ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV 250
+SG +LA D+ V LWS + + I+ L P + SV + G+ S +
Sbjct: 31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP---VESVRLNTPEELIVAGSQSGSI 87
Query: 251 QLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGH 308
++WD++ K LR + H A + SL ++ Y ++SGS+ +I D+R + V GH
Sbjct: 88 RVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR-RKGCVFRYRGH 146
Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368
SQ V LR++PDG+ LAS +D+ V +W G+ + F H G V V + P
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK----MMSEFPGHTGPVNVVEFHP--- 199
Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISG 417
N G+SDR IR W++ +S ++ V S+L++P L SG
Sbjct: 200 NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Score = 65.1 bits (157), Expect = 1e-10
Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 12/152 (7%)
Query: 321 GRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379
GR LA+GG+D VN+W + P + + T H V++V + ++A G+
Sbjct: 33 GRLLATGGDDCRVNLWSINKPN-----CIMSLTGHTSPVESVRLNTPEELIVA---GSQS 84
Query: 380 RHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
IR+W++ + L + H + +CS+ + P Y E ++ G + +W V
Sbjct: 85 GSIRVWDLEAAKILRTLMGHKANICSLDFHP-YGEFVAS-GSQDTNIKLWDIRRKGCVFR 142
Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
+GH+ V L SPDG +ASAA D T++LW
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Score = 59.7 bits (143), Expect = 6e-09
Identities = 47/215 (21%), Positives = 97/215 (45%), Gaps = 14/215 (6%)
Query: 260 RLRNMTSHSARVGSL---SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316
+L+ + +H++ V SL + +L++G ++ + + + +L+GH+ V +R
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSIN-KPNCIMSLTGHTSPVESVR 70
Query: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376
+ +G + VW + L+T H+ + ++ + P+ V + G
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAK----ILRTLMGHKANICSLDFHPYGEFVAS---G 123
Query: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAK 435
+ D +I++W++ C+ HSQ L +SP K L S + + +W
Sbjct: 124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD--DHTVKLWDLTAGKM 181
Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
++E GHT V + P+ +AS ++D T+R W
Sbjct: 182 MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 89.4 bits (220), Expect = 7e-18
Identities = 74/296 (25%), Positives = 130/296 (43%), Gaps = 29/296 (9%)
Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256
+++ + D ++ +W +GD + L+ + + +++ G LA ++ ++LWD Q
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHT--DSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 257 QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314
+ +R M H V S++ N + S SR I +V+ + V T +GH + V
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG-YCVKTFTGHREWVRM 239
Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP---WQSNVL 371
+R DG +AS ND V VW A E +H+ V+ ++W P + S
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECK----AELREHEHVVECISWAPESSYSSISE 295
Query: 372 ATGG--------------GTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELIS 416
ATG G+ D+ I++W+V +G CL + H V +L+ K ++S
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
L +W Y + L H V SL V + + D+T+++W C
Sbjct: 356 CAD--DKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 49.7 bits (117), Expect = 6e-06
Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 10/167 (5%)
Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364
LSGH V + + P + S D + VW G+ +T H +V+ +++
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE----RTLKGHTDSVQDISF- 158
Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQN 423
+LA+ ++D I++W+ C+ + H V S+ P+ ++S
Sbjct: 159 DHSGKLLASC--SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS--RDK 214
Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
+ +W+ T V GH V + + DG +AS + D+T+R+W
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 42.7 bits (99), Expect = 8e-04
Identities = 27/130 (20%), Positives = 59/130 (45%), Gaps = 8/130 (6%)
Query: 345 WVPLQ----TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 400
W+P + H+ V V + P S +++ + D I++W+ +G + H+
Sbjct: 94 WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSA---SEDATIKVWDYETGDFERTLKGHT 150
Query: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
+ H +L++ A + +W + + + GH V S+ + P+G + S
Sbjct: 151 DSVQDISFDHSGKLLASCS-ADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVS 209
Query: 461 AAADETLRLW 470
A+ D+T+++W
Sbjct: 210 ASRDKTIKMW 219
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 85.1 bits (209), Expect = 1e-16
Identities = 73/254 (28%), Positives = 116/254 (45%), Gaps = 15/254 (5%)
Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG--SLSWNSYIL 281
Q G ++S A+ +G L G+ V W+ + + L + H+ V S + ++
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341
+S S + DV A+ + L GH + V + ++PD R LASGG D V +W G
Sbjct: 79 ASASCDCTVRLWDVARAKC-LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN---VCSGACLSAVDA 398
+ L+ H+ ++++ + P N LATG S HI W+ V A++
Sbjct: 138 Q----MLRLLVGHRDSIQSSDFSP-TVNCLATGSWDSTVHI--WDLRMVTPAVSHQALEG 190
Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATV 458
HS S L L SG + IWK T + + +LKGH + V S+ SPD +
Sbjct: 191 HSANISCLCYSASGLLASGSW--DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWL 248
Query: 459 ASAAADETLRLWRC 472
ASA +++W C
Sbjct: 249 ASAGYSRMVKVWDC 262
Score = 74.3 bits (181), Expect = 2e-13
Identities = 75/272 (27%), Positives = 121/272 (44%), Gaps = 19/272 (6%)
Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK---EGNYLAVGTSSAEVQLWDVQQQK 259
D VY W SG +L L G + V + + +G+ A + V+LWDV + K
Sbjct: 42 DGCVYGWETRSGQLLWRL-----GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAK 96
Query: 260 RLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317
LR + H V ++S++ S L+SG + DV+ + + L GH + +
Sbjct: 97 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM-LRLLVGHRDSIQSSDF 155
Query: 318 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 377
+P LA+G D+ V++W V Q H + + C S +LA+G
Sbjct: 156 SPTVNCLATGSWDSTVHIWDLRMVTPA-VSHQALEGHSANISCL--CYSASGLLASGSW- 211
Query: 378 SDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436
D+ I IW + + L + H + V SI +SP L S G+++ + +W T +
Sbjct: 212 -DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA-GYSR-MVKVWDCNTGKCL 268
Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLR 468
LKG + +PDG + S AAD+T R
Sbjct: 269 ETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 10/199 (5%)
Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356
+A V H EV ++PDG+ L +G D V W + G+ W H G
Sbjct: 9 LAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLW----RLGGHTG 64
Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELI 415
VK +C + + + D +R+W+V CL + H + V ++ +SP ++L
Sbjct: 65 PVK---FCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA 121
Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475
SG ++++W + + L GH + S SP +A+ + D T+ +W +
Sbjct: 122 SGGW--DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 476 DPARRREREKASAAKSSLI 494
PA + + +A S +
Sbjct: 180 TPAVSHQALEGHSANISCL 198
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.0 bits (201), Expect = 1e-15
Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 19/284 (6%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW+S G +LA+ + D +W+ + L Q + P I ++ W K+GNY+
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGP---IFALKWNKKGNYVLSAGVD 297
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + + H +H V T G
Sbjct: 298 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG 357
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W + H + + W P
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD----ACVHDLQAHSKEIYTIKWSPTG 413
Query: 367 -----QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGF 420
++ + + D +R+W+V G C + H + V S+ +SP K L SG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS-- 471
Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + + V +G T + + + G V ++A+D
Sbjct: 472 FDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 68.6 bits (166), Expect = 1e-11
Identities = 66/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WNS
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245
Query: 279 --YILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L+ GS G I + +A +TL H + L+W G ++ S G D
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLA----STLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ AC+ + AHS ++ +I WSP
Sbjct: 362 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 470 W 470
W
Sbjct: 479 W 479
Score = 45.8 bits (107), Expect = 9e-05
Identities = 51/224 (22%), Positives = 76/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
DV + + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 164 DVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W S+ G+ D RIW +G S + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFAL 282
Query: 401 --------------QVCSILWSPHYKELISGHGFA---------QNQLVIWKYPTMA--- 434
+I+W H E F QN + T
Sbjct: 283 KWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIH 342
Query: 435 --------KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 30.4 bits (67), Expect = 3.9
Identities = 14/40 (35%), Positives = 19/40 (47%)
Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
K L+GH S V +P +AS + D T R+W E
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 210
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.0 bits (201), Expect = 1e-15
Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 19/284 (6%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW+S G +LA+ + D +W+ + L Q + P I ++ W K+GNY+
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGP---IFALKWNKKGNYVLSAGVD 297
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + + H +H V T G
Sbjct: 298 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG 357
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W + H + + W P
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD----ACVHDLQAHSKEIYTIKWSPTG 413
Query: 367 -----QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGF 420
++ + + D +R+W+V G C + H + V S+ +SP K L SG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS-- 471
Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + + V +G T + + + G V ++A+D
Sbjct: 472 FDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 68.6 bits (166), Expect = 1e-11
Identities = 66/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WNS
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245
Query: 279 --YILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L+ GS G I + +A +TL H + L+W G ++ S G D
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLA----STLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ AC+ + AHS ++ +I WSP
Sbjct: 362 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 470 W 470
W
Sbjct: 479 W 479
Score = 45.8 bits (107), Expect = 9e-05
Identities = 51/224 (22%), Positives = 76/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
DV + + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 164 DVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W S+ G+ D RIW +G S + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFAL 282
Query: 401 --------------QVCSILWSPHYKELISGHGFA---------QNQLVIWKYPTMA--- 434
+I+W H E F QN + T
Sbjct: 283 KWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIH 342
Query: 435 --------KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 30.4 bits (67), Expect = 3.9
Identities = 14/40 (35%), Positives = 19/40 (47%)
Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
K L+GH S V +P +AS + D T R+W E
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 210
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.0 bits (201), Expect = 1e-15
Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 19/284 (6%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW+S G +LA+ + D +W+ + L Q + P I ++ W K+GNY+
Sbjct: 241 LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGP---IFALKWNKKGNYVLSAGVD 297
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + + H +H V T G
Sbjct: 298 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG 357
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W + H + + W P
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD----ACVHDLQAHSKEIYTIKWSPTG 413
Query: 367 -----QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGF 420
++ + + D +R+W+V G C + H + V S+ +SP K L SG
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS-- 471
Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + + V +G T + + + G V ++A+D
Sbjct: 472 FDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 68.6 bits (166), Expect = 1e-11
Identities = 66/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WNS
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245
Query: 279 --YILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L+ GS G I + +A +TL H + L+W G ++ S G D
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLA----STLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ AC+ + AHS ++ +I WSP
Sbjct: 362 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 470 W 470
W
Sbjct: 479 W 479
Score = 45.8 bits (107), Expect = 9e-05
Identities = 51/224 (22%), Positives = 76/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
DV + + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 164 DVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W S+ G+ D RIW +G S + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFAL 282
Query: 401 --------------QVCSILWSPHYKELISGHGFA---------QNQLVIWKYPTMA--- 434
+I+W H E F QN + T
Sbjct: 283 KWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIH 342
Query: 435 --------KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 30.4 bits (67), Expect = 3.9
Identities = 14/40 (35%), Positives = 19/40 (47%)
Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
K L+GH S V +P +AS + D T R+W E
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 210
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 81.6 bits (200), Expect = 1e-15
Identities = 82/332 (24%), Positives = 135/332 (40%), Gaps = 59/332 (17%)
Query: 190 VDWS-SGNVLAVALDNS-VYLWSASSGDILQLLQMEQPGEYISSVAWIK-----EGNYLA 242
+ WS G LA N + LW S+G + + ++I+ ++W E Y+A
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRT-LAGHSKWITGLSWEPLHANPECRYVA 220
Query: 243 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-ILSSGSRS-------------- 287
+ V++WD + R +T H+ V L W +L S S+
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 288 ----GHIH---------HHDVRVAEHHVATLSGHSQEVCG--------------LRWAPD 320
GH H + +R A S + Q++ G L
Sbjct: 281 RTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340
Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380
L SG +D + +W A + PL T HQ + V + P S ++A+ + D+
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKK---PLTRMTGHQALINQVLFSP-DSRIVASA--SFDK 394
Query: 381 HIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439
I++W+ +G L+++ H + V I WS + L+SG + + L +W +L
Sbjct: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGS--SDSTLKVWDVKAQKLAMDL 452
Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
GH V ++ SPDG VAS D+ LR+WR
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 77.8 bits (190), Expect = 2e-14
Identities = 71/298 (23%), Positives = 118/298 (39%), Gaps = 57/298 (19%)
Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSY 279
+E E + SVA+ G YLA G+ V+ WD+ + H V S+SW +
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
Query: 280 ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA-----PDGRHLASGGNDNLVN 334
L+SG ++G I D + TL+GHS+ + GL W P+ R++AS D V
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394
+W + G + T H +V + W +L + + DR I++W G
Sbjct: 230 IWDTTAGRCE----RILTGHTQSVTCLRW--GGDGLLYS--ASQDRTIKVWRAHDGVLCR 281
Query: 395 AVDAHSQ-VCSILWSPHY---------------------------KELISGHGFAQNQ-- 424
+ H V ++ S Y + +S + + Q
Sbjct: 282 TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGP 341
Query: 425 -----------LVIWKYPTMAK-VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
L +W K + + GH + + + SPD VASA+ D++++LW
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 13/185 (7%)
Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
VR ++L GHS+ V + ++P G++LASG D V W + P T H
Sbjct: 100 VRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE----TPHFTCKGH 155
Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS-AVDAHSQ-VCSILWSPHYK 412
+ V +++W P LA+ G + I +W+ +G + + HS+ + + W P +
Sbjct: 156 RHWVLSISWSP-DGRKLAS--GCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
Query: 413 E---LISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
+ IW L GHT V L DG + SA+ D T+++
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271
Query: 470 WRCFE 474
WR +
Sbjct: 272 WRAHD 276
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/165 (32%), Positives = 81/165 (49%), Gaps = 10/165 (6%)
Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366
GH+ V L +P + ASG +D +W PL+ + H V V + P
Sbjct: 382 GHAYPVWDLDISPYSLYFASGSHDRTARLWSF----DRTYPLRIYAGHLADVDCVKFHP- 436
Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQL 425
SN LATG ++D+ +R+W+ G + H V S+ +SP+ K L S +L
Sbjct: 437 NSNYLATG--STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG--EDQRL 492
Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
+W + EL+GHT + SLT SPD +ASA+ D ++R+W
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/190 (23%), Positives = 84/190 (44%), Gaps = 10/190 (5%)
Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV 297
Y A G+ +LW + LR H A V + + NS L++GS + +
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357
+ V +GH V L ++P+G++LAS G D + +W A G + H
Sbjct: 458 G-NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG----TLYKELRGHTDN 512
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG 417
+ ++ + P S ++A+ + D +R+W++ + C + D S +++ ++S
Sbjct: 513 ITSLTFSP-DSGLIASA--SMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSV 569
Query: 418 HGFAQNQLVI 427
A N L++
Sbjct: 570 QFMACNLLLV 579
Score = 56.6 bits (135), Expect = 5e-08
Identities = 38/123 (30%), Positives = 56/123 (45%), Gaps = 9/123 (7%)
Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSR 286
+ V + NYLA G++ V+LW QQ +R T H V SL++ N L+S
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 287 SGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP------SAP 340
+ D+ + L GH+ + L ++PD +AS DN V VW SAP
Sbjct: 489 DQRLKLWDLASGTLY-KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAP 547
Query: 341 GEG 343
+G
Sbjct: 548 ADG 550
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 79.3 bits (194), Expect = 7e-15
Identities = 77/287 (26%), Positives = 129/287 (44%), Gaps = 25/287 (8%)
Query: 196 NVLAVA-LDNSVYLWSASSGDILQLLQM-EQPGE--YISSVAWIKEG-NYLAVGTSSAEV 250
N+LA A D ++ +W DI L + PG I S++W G N +A GTS
Sbjct: 383 NLLATASFDGTIKVW-----DINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGA 437
Query: 251 QLWDVQQQKRLRNMTSHSAR-VGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS 306
+W+VQ+ K ++ H + ++W+ S +++ S G +R + V
Sbjct: 438 FIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI---IRTIDGKVLHKY 494
Query: 307 GHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365
H V G W+ + + + A+G D V V+ A PL+ F+ H V V W P
Sbjct: 495 KHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ--PLKVFSGHTAKVFHVKWSP 552
Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQ 424
+ +L +G + D +RIW+ AC++ ++ H + V ++W+ L+ G
Sbjct: 553 LREGILCSG--SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLIS-GSWDYT 609
Query: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLW 470
+ +W V + H + V LT P T+AS + D T+RLW
Sbjct: 610 IKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
Score = 48.1 bits (113), Expect = 2e-05
Identities = 44/155 (28%), Positives = 69/155 (44%), Gaps = 11/155 (7%)
Query: 191 DWSSGN--VLAVALDNS---VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245
DWS N ++A +++ VY + SS L++ + + ++EG L G+
Sbjct: 504 DWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGS 562
Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHV 302
V++WD Q + + H+A V L WN+ Y+L SGS I D R V
Sbjct: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGT-CV 621
Query: 303 ATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336
T+ H +V GL P +AS D+ V +W
Sbjct: 622 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 24/164 (14%)
Query: 272 GSLSWNSYILS-SGSRSGH-------IHHHDVRVAEHHV-ATLSGHSQEVCGLRWAPDGR 322
G WN + + SG R + I+ D R E + A +S H + + + W P
Sbjct: 13 GCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNP 72
Query: 323 HL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR- 380
L ASG DNLV +W A + + +G +++WC +V+A S R
Sbjct: 73 DLFASGSTDNLVIIWNVAEQK----VIAKLDSTKGIPASLSWCWNAEDVVAF---VSHRG 125
Query: 381 HIRIWNVC--SGACLSAVDAH---SQVCSILWSPHYK-ELISGH 418
+ IW + + DAH S +C W H K +++ GH
Sbjct: 126 PLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGH 169
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 79.3 bits (194), Expect = 7e-15
Identities = 77/287 (26%), Positives = 129/287 (44%), Gaps = 25/287 (8%)
Query: 196 NVLAVA-LDNSVYLWSASSGDILQLLQM-EQPGE--YISSVAWIKEG-NYLAVGTSSAEV 250
N+LA A D ++ +W DI L + PG I S++W G N +A GTS
Sbjct: 407 NLLATASFDGTIKVW-----DINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGA 461
Query: 251 QLWDVQQQKRLRNMTSHSAR-VGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS 306
+W+VQ+ K ++ H + ++W+ S +++ S G +R + V
Sbjct: 462 FIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI---IRTIDGKVLHKY 518
Query: 307 GHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365
H V G W+ + + + A+G D V V+ A PL+ F+ H V V W P
Sbjct: 519 KHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ--PLKVFSGHTAKVFHVKWSP 576
Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQ 424
+ +L +G + D +RIW+ AC++ ++ H + V ++W+ L+ G
Sbjct: 577 LREGILCSG--SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLIS-GSWDYT 633
Query: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLW 470
+ +W V + H + V LT P T+AS + D T+RLW
Sbjct: 634 IKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 680
Score = 48.1 bits (113), Expect = 2e-05
Identities = 44/155 (28%), Positives = 69/155 (44%), Gaps = 11/155 (7%)
Query: 191 DWSSGN--VLAVALDNS---VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245
DWS N ++A +++ VY + SS L++ + + ++EG L G+
Sbjct: 528 DWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGS 586
Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHV 302
V++WD Q + + H+A V L WN+ Y+L SGS I D R V
Sbjct: 587 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGT-CV 645
Query: 303 ATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336
T+ H +V GL P +AS D+ V +W
Sbjct: 646 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 680
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 24/164 (14%)
Query: 272 GSLSWNSYILS-SGSRSGH-------IHHHDVRVAEHHV-ATLSGHSQEVCGLRWAPDGR 322
G WN + + SG R + I+ D R E + A +S H + + + W P
Sbjct: 37 GCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNP 96
Query: 323 HL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR- 380
L ASG DNLV +W A + + +G +++WC +V+A S R
Sbjct: 97 DLFASGSTDNLVIIWNVAEQK----VIAKLDSTKGIPASLSWCWNAEDVVAF---VSHRG 149
Query: 381 HIRIWNVC--SGACLSAVDAH---SQVCSILWSPHYK-ELISGH 418
+ IW + + DAH S +C W H K +++ GH
Sbjct: 150 PLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGH 193
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 79.3 bits (194), Expect = 7e-15
Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 9/169 (5%)
Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366
GH + V + W+P G +LAS D +W + + + T H+ VK+VAW P
Sbjct: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKK--NQDDFECVTTLEGHENEVKSVAWAP- 115
Query: 367 QSNVLATGGGTSDRHIRIWNVCSG---ACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422
N+LAT + D+ + +W V C+S +++H+Q V ++W P + L S
Sbjct: 116 SGNLLATC--SRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDT 173
Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
+L + A L+GH S V SL P G +AS + D T+R+WR
Sbjct: 174 VKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR 222
Score = 67.8 bits (164), Expect = 2e-11
Identities = 75/273 (27%), Positives = 115/273 (42%), Gaps = 38/273 (13%)
Query: 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
V WS GN LA A D + +W + D + +E + SVAW GN LA +
Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD 126
Query: 248 AEVQLWDVQQQKR---LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHH- 301
V +W+V ++ + + SH+ V + W + +L+S S + + R E
Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY--REEEDDW 184
Query: 302 --VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APG----------EGGWVPL 348
ATL GH V L + P G+ LAS +D V +W PG + W +
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
Query: 349 QTFTQ-HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA-------CLSA--VDA 398
T + H + +AWC + LAT G D IR++ + L+A A
Sbjct: 245 CTLSGFHSRTIYDIAWCQ-LTGALATACG--DDAIRVFQEDPNSDPQQPTFSLTAHLHQA 301
Query: 399 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKY 430
HSQ V + W+P L++ ++ WKY
Sbjct: 302 HSQDVNCVAWNPKEPGLLASCS-DDGEVAFWKY 333
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/315 (23%), Positives = 132/315 (41%), Gaps = 41/315 (13%)
Query: 192 WSSGNVLAVAL--DNSVYLWSASSGD--ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
W+ L + D + +W + GD I + + E + VAW GNYLA +
Sbjct: 24 WNPAGTLLASCGGDRRIRIWG-TEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82
Query: 248 AEVQLWDVQQQ--KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHH-- 301
A +W Q + + + H V S++W + +L++ SR + +V + +
Sbjct: 83 ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYEC 142
Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361
V+ L+ H+Q+V + W P LAS D+ V ++ E WV T H+ V ++
Sbjct: 143 VSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE--EDDWVCCATLEGHESTVWSL 200
Query: 362 AWCPWQSNVLATGGGTSDRHIRIWN----------VCSGA-----CLSAVDA-HSQ-VCS 404
A+ P + + + DR +RIW CSG+ C+ + HS+ +
Sbjct: 201 AFDPSGQRLASC---SDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYD 257
Query: 405 ILWSPHYKELISGHG------FAQNQLVIWKYPTMAKVAEL-KGHTSRVLSLTMSP-DGA 456
I W L + G F ++ + PT + A L + H+ V + +P +
Sbjct: 258 IAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPG 317
Query: 457 TVASAAADETLRLWR 471
+AS + D + W+
Sbjct: 318 LLASCSDDGEVAFWK 332
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.0 bits (193), Expect = 1e-14
Identities = 75/321 (23%), Positives = 137/321 (42%), Gaps = 23/321 (7%)
Query: 159 GSSRKTCRYIPSLPDRILDAPE-IRNDYYLNLVDWSSGNVLAV-ALDNSVYLWSASSGDI 216
GS +TC+ + L+ E RN Y + G+ +A + D + LWS +G
Sbjct: 110 GSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 169
Query: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276
+ I +++ + +A G+ +LWD+Q + + + HSA + SLS+
Sbjct: 170 YHTFRGHTAE--IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 277 NSYILSSGSR--SGHIHHHDV---RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDN 331
N +SG R +G H V V L GH E+ + D + +G D
Sbjct: 228 N----TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391
+W + G+ + T T H + + + ++AT ++D RI++ +
Sbjct: 284 TCKLWDATNGK----CVATLTGHDDEILDSCF-DYTGKLIAT--ASADGTARIFSAATRK 336
Query: 392 CLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450
C++ ++ H ++ I ++P L++G + IW T + L+GHT + S
Sbjct: 337 CIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
Query: 451 MSPDGATVASAAADETLRLWR 471
+ G V + + D T R+WR
Sbjct: 395 FNYKGNIVITGSKDNTCRIWR 415
Score = 70.1 bits (170), Expect = 4e-12
Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 56/298 (18%)
Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE-GNYLAVGTSSAEVQLWDVQQQKRL 261
D + LW +SG+ L L+ + Y ++A+ G+ +A G+ +LW V+ K
Sbjct: 113 DRTCKLWDTASGEELNTLEGHRNVVY--AIAFNNPYGDKIATGSFDKTCKLWSVETGKCY 170
Query: 262 RNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319
H+A + LS+N S ++++GS D++ E V TL GHS E+ L +
Sbjct: 171 HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE-VYTLRGHSAEIISLSFNT 229
Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379
G + +G D+ V VW + G + H + + ++ W +++ TG + D
Sbjct: 230 SGDRIITGSFDHTVVVWDADTGR----KVNILIGHCAEISSASF-NWDCSLILTG--SMD 282
Query: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439
+ ++W+ +G C VA L
Sbjct: 283 KTCKLWDATNGKC-------------------------------------------VATL 299
Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497
GH +L G +A+A+AD T R++ + E + +K S QG
Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 79.0 bits (193), Expect = 1e-14
Identities = 61/279 (21%), Positives = 112/279 (40%), Gaps = 58/279 (20%)
Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
N+ + A D SV LWS S + + +E ++ V W G +L +LWD+
Sbjct: 295 NLASCAADGSVKLWSLDSDE--PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 256 QQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
+ Q+ + + HS V ++++ + +G D+R + L GH +E+
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRC-IMFLEGHLKEIY 411
Query: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
G+ ++P+G H+A+
Sbjct: 412 GINFSPNGYHIAT----------------------------------------------- 424
Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSP-HYKELISGHGFAQNQLVIWKYP 431
G+ D ++W++ C+ + AH V + + P H L++G N IW +P
Sbjct: 425 --GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA--YDNTAKIWTHP 480
Query: 432 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
+ + L GH +V+ L +S DG +A+ + D T +LW
Sbjct: 481 GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 30.0 bits (66), Expect = 5.1
Identities = 17/72 (23%), Positives = 31/72 (43%), Gaps = 8/72 (11%)
Query: 427 IWKYPTMAKVAELKGHTSRV--------LSLTMSPDGATVASAAADETLRLWRCFELDPA 478
+W P + L+GH + V ++++ P +AS AAD +++LW +P
Sbjct: 257 LWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV 316
Query: 479 RRREREKASAAK 490
E A+
Sbjct: 317 ADIEGHTVRVAR 328
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 77.8 bits (190), Expect = 2e-14
Identities = 69/301 (22%), Positives = 136/301 (45%), Gaps = 27/301 (8%)
Query: 176 LDAPEI---RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSV 232
L +P++ +D+ + + + +++ + DN++ +WSA +G L+ L G + S +
Sbjct: 252 LKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM 311
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH 292
N + G++ +++W+ + + + + H++ V + + + SGSR +
Sbjct: 312 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 367
Query: 293 HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352
D+ + + L GH V +++ DGR + SG D +V VW L T
Sbjct: 368 WDIETGQ-CLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE----TCLHTLQ 420
Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYK 412
H V ++ Q + + G+ D IR+W+V +G C+ + H + S K
Sbjct: 421 GHTNRVYSL-----QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELK 472
Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKG---HTSRVLSLTMSPDGATVASAAADETLRL 469
+ I G A + + IW T + L+G H S V L + + V +++ D T++L
Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKL 530
Query: 470 W 470
W
Sbjct: 531 W 531
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/156 (21%), Positives = 63/156 (40%), Gaps = 10/156 (6%)
Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249
V + V++ A D V +W + L LQ Y +G ++ G+
Sbjct: 389 VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTS 444
Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG-- 307
+++WDV+ + +T H + + IL SG+ + D++ + + TL G
Sbjct: 445 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ-CLQTLQGPN 503
Query: 308 -HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342
H V L++ + + + +D V +W GE
Sbjct: 504 KHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGE 537
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRL 261
D++V +W +G LQ LQ P ++ S+V ++ N++ + V+LWD++ + +
Sbjct: 482 DSTVKIWDIKTGQCLQTLQ--GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 539
Query: 262 RNM-TSHSARVGSLSW------NSYILSSGSRSG 288
RN+ T S G + W + + GSR+G
Sbjct: 540 RNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNG 573
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 77.8 bits (190), Expect = 2e-14
Identities = 69/301 (22%), Positives = 136/301 (45%), Gaps = 27/301 (8%)
Query: 176 LDAPEI---RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSV 232
L +P++ +D+ + + + +++ + DN++ +WSA +G L+ L G + S +
Sbjct: 370 LKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM 429
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH 292
N + G++ +++W+ + + + + H++ V + + + SGSR +
Sbjct: 430 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 485
Query: 293 HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352
D+ + + L GH V +++ DGR + SG D +V VW L T
Sbjct: 486 WDIETGQ-CLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE----TCLHTLQ 538
Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYK 412
H V ++ Q + + G+ D IR+W+V +G C+ + H + S K
Sbjct: 539 GHTNRVYSL-----QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELK 590
Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKG---HTSRVLSLTMSPDGATVASAAADETLRL 469
+ I G A + + IW T + L+G H S V L + + V +++ D T++L
Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKL 648
Query: 470 W 470
W
Sbjct: 649 W 649
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/156 (21%), Positives = 63/156 (40%), Gaps = 10/156 (6%)
Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249
V + V++ A D V +W + L LQ Y +G ++ G+
Sbjct: 507 VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTS 562
Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG-- 307
+++WDV+ + +T H + + IL SG+ + D++ + + TL G
Sbjct: 563 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ-CLQTLQGPN 621
Query: 308 -HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342
H V L++ + + + +D V +W GE
Sbjct: 622 KHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGE 655
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRL 261
D++V +W +G LQ LQ P ++ S+V ++ N++ + V+LWD++ + +
Sbjct: 600 DSTVKIWDIKTGQCLQTLQ--GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 657
Query: 262 RNM-TSHSARVGSLSW------NSYILSSGSRSG 288
RN+ T S G + W + + GSR+G
Sbjct: 658 RNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNG 691
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 77.8 bits (190), Expect = 2e-14
Identities = 69/301 (22%), Positives = 136/301 (45%), Gaps = 27/301 (8%)
Query: 176 LDAPEI---RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSV 232
L +P++ +D+ + + + +++ + DN++ +WSA +G L+ L G + S +
Sbjct: 290 LKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM 349
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH 292
N + G++ +++W+ + + + + H++ V + + + SGSR +
Sbjct: 350 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 405
Query: 293 HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352
D+ + + L GH V +++ DGR + SG D +V VW L T
Sbjct: 406 WDIETGQ-CLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE----TCLHTLQ 458
Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYK 412
H V ++ Q + + G+ D IR+W+V +G C+ + H + S K
Sbjct: 459 GHTNRVYSL-----QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELK 510
Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKG---HTSRVLSLTMSPDGATVASAAADETLRL 469
+ I G A + + IW T + L+G H S V L + + V +++ D T++L
Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKL 568
Query: 470 W 470
W
Sbjct: 569 W 569
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/156 (21%), Positives = 63/156 (40%), Gaps = 10/156 (6%)
Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249
V + V++ A D V +W + L LQ Y +G ++ G+
Sbjct: 427 VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF----DGIHVVSGSLDTS 482
Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG-- 307
+++WDV+ + +T H + + IL SG+ + D++ + + TL G
Sbjct: 483 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ-CLQTLQGPN 541
Query: 308 -HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342
H V L++ + + + +D V +W GE
Sbjct: 542 KHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGE 575
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRL 261
D++V +W +G LQ LQ P ++ S+V ++ N++ + V+LWD++ + +
Sbjct: 520 DSTVKIWDIKTGQCLQTLQ--GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 577
Query: 262 RNM-TSHSARVGSLSW------NSYILSSGSRSG 288
RN+ T S G + W + + GSR+G
Sbjct: 578 RNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNG 611
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW++ G +LA + D +W+ L Q + P I ++ W ++GNY+
Sbjct: 243 LDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGP---IFALKWNRKGNYILSAGVD 299
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + H + V T G
Sbjct: 300 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W V + H + + W P
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE----VCIHDLQAHNKEIYTIKWSPTG 415
Query: 367 ------QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
SN++ + D +R+W++ G C + H + V S+ +SP K L SG
Sbjct: 416 PATSNPNSNIM-LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS- 473
Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + V +G T + + + G V ++A+D
Sbjct: 474 -FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASD 516
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WN+
Sbjct: 188 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 247
Query: 279 Y--ILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L++GS G I D +A +TL H + L+W G ++ S G D
Sbjct: 248 NGTLLATGSYDGFARIWTEDGNLA----STLGQHKGPIFALKWNRKGNYILSAGVDKTTI 303
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 304 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 363
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ C+ + AH+ ++ +I WSP
Sbjct: 364 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 470 W 470
W
Sbjct: 481 W 481
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/224 (22%), Positives = 75/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
+V + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 166 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W +N G+ D RIW G S + H
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFAL 284
Query: 401 --------------QVCSILWSPHYKELISGHGF--AQNQLVIWKYPTM----------- 433
+I+W H E F A V W+ T
Sbjct: 285 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 344
Query: 434 -------AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Score = 30.8 bits (68), Expect = 3.0
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
+K L+GH S V +P +AS + D T R+W E
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 212
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW++ G +LA + D +W+ L Q + P I ++ W ++GNY+
Sbjct: 243 LDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGP---IFALKWNRKGNYILSAGVD 299
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + H + V T G
Sbjct: 300 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W V + H + + W P
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE----VCIHDLQAHNKEIYTIKWSPTG 415
Query: 367 ------QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
SN++ + D +R+W++ G C + H + V S+ +SP K L SG
Sbjct: 416 PATSNPNSNIM-LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS- 473
Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + V +G T + + + G V ++A+D
Sbjct: 474 -FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASD 516
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WN+
Sbjct: 188 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 247
Query: 279 Y--ILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L++GS G I D +A +TL H + L+W G ++ S G D
Sbjct: 248 NGTLLATGSYDGFARIWTEDGNLA----STLGQHKGPIFALKWNRKGNYILSAGVDKTTI 303
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 304 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 363
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ C+ + AH+ ++ +I WSP
Sbjct: 364 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 470 W 470
W
Sbjct: 481 W 481
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/224 (22%), Positives = 75/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
+V + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 166 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W +N G+ D RIW G S + H
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFAL 284
Query: 401 --------------QVCSILWSPHYKELISGHGF--AQNQLVIWKYPTM----------- 433
+I+W H E F A V W+ T
Sbjct: 285 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 344
Query: 434 -------AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Score = 30.8 bits (68), Expect = 3.0
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
+K L+GH S V +P +AS + D T R+W E
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 212
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW++ G +LA + D +W+ L Q + P I ++ W ++GNY+
Sbjct: 294 LDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGP---IFALKWNRKGNYILSAGVD 350
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + H + V T G
Sbjct: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W V + H + + W P
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE----VCIHDLQAHNKEIYTIKWSPTG 466
Query: 367 ------QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
SN++ + D +R+W++ G C + H + V S+ +SP K L SG
Sbjct: 467 PATSNPNSNIM-LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS- 524
Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + V +G T + + + G V ++A+D
Sbjct: 525 -FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WN+
Sbjct: 239 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 298
Query: 279 Y--ILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L++GS G I D +A +TL H + L+W G ++ S G D
Sbjct: 299 NGTLLATGSYDGFARIWTEDGNLA----STLGQHKGPIFALKWNRKGNYILSAGVDKTTI 354
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 355 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 414
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ C+ + AH+ ++ +I WSP
Sbjct: 415 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
Query: 470 W 470
W
Sbjct: 532 W 532
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/224 (22%), Positives = 75/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
+V + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 217 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W +N G+ D RIW G S + H
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFAL 335
Query: 401 --------------QVCSILWSPHYKELISGHGF--AQNQLVIWKYPTM----------- 433
+I+W H E F A V W+ T
Sbjct: 336 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 395
Query: 434 -------AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
Score = 30.8 bits (68), Expect = 3.0
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
+K L+GH S V +P +AS + D T R+W E
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 263
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 190 VDWSS-GNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247
+DW++ G +LA + D +W+ L Q + P I ++ W ++GNY+
Sbjct: 294 LDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGP---IFALKWNRKGNYILSAGVD 350
Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 307
+WD + + HSA + W + + + H + V T G
Sbjct: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410
Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW- 366
H+ EV ++W P G LAS +D + +W V + H + + W P
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE----VCIHDLQAHNKEIYTIKWSPTG 466
Query: 367 ------QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
SN++ + D +R+W++ G C + H + V S+ +SP K L SG
Sbjct: 467 PATSNPNSNIM-LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGS- 524
Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464
+ IW + V +G T + + + G V ++A+D
Sbjct: 525 -FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/301 (21%), Positives = 113/301 (37%), Gaps = 70/301 (23%)
Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVG-----------SLSWNS 278
AW + LA G+ + ++W++ + + + H R G SL WN+
Sbjct: 239 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 298
Query: 279 Y--ILSSGSRSG--HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334
+L++GS G I D +A +TL H + L+W G ++ S G D
Sbjct: 299 NGTLLATGSYDGFARIWTEDGNLA----STLGQHKGPIFALKWNRKGNYILSAGVDKTTI 354
Query: 335 VWPSAPGEG--------------GWV-----------------------PLQTFTQHQGA 357
+W + GE W P++TF H
Sbjct: 355 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 414
Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPH------ 410
V A+ W P + + + D ++IW++ C+ + AH+ ++ +I WSP
Sbjct: 415 VNAIKWDP---SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
Query: 411 -YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469
++ + + +W L H V S+ SPDG +AS + D+ + +
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
Query: 470 W 470
W
Sbjct: 532 W 532
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/224 (22%), Positives = 75/224 (33%), Gaps = 48/224 (21%)
Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQT 350
+V + L GH EV W P LASG D+ +W ++ G + L+
Sbjct: 217 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 351 FTQHQG----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS------ 400
+ G + K V W +N G+ D RIW G S + H
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFAL 335
Query: 401 --------------QVCSILWSPHYKELISGHGF--AQNQLVIWKYPTM----------- 433
+I+W H E F A V W+ T
Sbjct: 336 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 395
Query: 434 -------AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
V +GHT+ V ++ P G +AS + D TL++W
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
Score = 30.8 bits (68), Expect = 3.0
Identities = 14/41 (34%), Positives = 20/41 (48%)
Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
+K L+GH S V +P +AS + D T R+W E
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNE 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.128 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,418,230
Number of Sequences: 37866
Number of extensions: 1043196
Number of successful extensions: 7162
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 4762
Number of HSP's gapped (non-prelim): 1470
length of query: 499
length of database: 18,247,518
effective HSP length: 106
effective length of query: 393
effective length of database: 14,233,722
effective search space: 5593852746
effective search space used: 5593852746
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.