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Search of human proteins with 117553580
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
(1153 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 2269 0.0
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 1740 0.0
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 170 6e-42
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 167 4e-41
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 164 4e-40
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 149 2e-35
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 144 4e-34
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 137 8e-32
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 137 8e-32
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 92 2e-18
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 92 2e-18
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 88 4e-17
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 88 4e-17
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 83 2e-15
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 83 2e-15
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 83 2e-15
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 79 2e-14
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 70 9e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 69 3e-11
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens] 69 3e-11
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 69 3e-11
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 67 7e-11
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 67 1e-10
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 67 1e-10
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens] 66 2e-10
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens] 66 2e-10
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 66 2e-10
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 66 2e-10
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 65 3e-10
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 64 6e-10
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 2269 bits (5879), Expect = 0.0
Identities = 1153/1153 (100%), Positives = 1153/1153 (100%)
Query: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC
Sbjct: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
Query: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL
Sbjct: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
Query: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPES 180
SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPES
Sbjct: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPES 180
Query: 181 LRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIK 240
LRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIK
Sbjct: 181 LRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIK 240
Query: 241 IIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSAS 300
IIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSAS
Sbjct: 241 IIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSAS 300
Query: 301 IQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRA 360
IQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRA
Sbjct: 301 IQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRA 360
Query: 361 LDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYIS 420
LDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYIS
Sbjct: 361 LDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYIS 420
Query: 421 ILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICE 480
ILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICE
Sbjct: 421 ILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICE 480
Query: 481 VLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQA 540
VLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQA
Sbjct: 481 VLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQA 540
Query: 541 GEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALF 600
GEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALF
Sbjct: 541 GEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALF 600
Query: 601 AGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEA 660
AGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEA
Sbjct: 601 AGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEA 660
Query: 661 DEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPM 720
DEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPM
Sbjct: 661 DEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPM 720
Query: 721 SDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEE 780
SDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEE
Sbjct: 721 SDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEE 780
Query: 781 MPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKK 840
MPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKK
Sbjct: 781 MPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKK 840
Query: 841 SKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEE 900
SKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEE
Sbjct: 841 SKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEE 900
Query: 901 AAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSI 960
AAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSI
Sbjct: 901 AAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSI 960
Query: 961 LKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGT 1020
LKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGT
Sbjct: 961 LKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGT 1020
Query: 1021 LSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMS 1080
LSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMS
Sbjct: 1021 LSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMS 1080
Query: 1081 FQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLS 1140
FQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLS
Sbjct: 1081 FQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLS 1140
Query: 1141 NLLEEMKATLAKC 1153
NLLEEMKATLAKC
Sbjct: 1141 NLLEEMKATLAKC 1153
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 1740 bits (4506), Expect = 0.0
Identities = 896/946 (94%), Positives = 896/946 (94%), Gaps = 50/946 (5%)
Query: 258 KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ 317
KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ
Sbjct: 167 KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ 226
Query: 318 NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV 377
NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV
Sbjct: 227 NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV 286
Query: 378 KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI 437
KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI
Sbjct: 287 KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI 346
Query: 438 AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ 497
AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ
Sbjct: 347 AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ 406
Query: 498 EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL 557
EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL
Sbjct: 407 EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL 466
Query: 558 PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV 617
PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV
Sbjct: 467 PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV 526
Query: 618 PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA 677
PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA
Sbjct: 527 PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA 586
Query: 678 NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL 737
NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL
Sbjct: 587 NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL 646
Query: 738 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND 797
EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND
Sbjct: 647 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND 706
Query: 798 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 857
PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD
Sbjct: 707 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 766
Query: 858 KEKKKEKEK--------------------------------------------------K 867
KEKKKEKEK K
Sbjct: 767 KEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDK 826
Query: 868 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE 927
KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE
Sbjct: 827 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE 886
Query: 928 NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG 987
NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG
Sbjct: 887 NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG 946
Query: 988 VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY 1047
VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY
Sbjct: 947 VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY 1006
Query: 1048 LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY 1107
LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY
Sbjct: 1007 LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY 1066
Query: 1108 SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1153
SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC
Sbjct: 1067 SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1112
Score = 332 bits (851), Expect = 1e-90
Identities = 168/169 (99%), Positives = 168/169 (99%)
Query: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC
Sbjct: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
Query: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL
Sbjct: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
Query: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLI 169
SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKA LI
Sbjct: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLI 169
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 170 bits (431), Expect = 6e-42
Identities = 158/696 (22%), Positives = 304/696 (43%), Gaps = 93/696 (13%)
Query: 18 LQDLVRGIRNHKE--DEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
L++L+R IR + +E + I + I+ ++++ + V KL Y+ MLGY +
Sbjct: 7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFG 66
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++ KFT KRIGYL A E DV +L TN I+ DL+ +Q+ G+AL L
Sbjct: 67 QLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTL 126
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDP 195
C + ++ RDLA ++ L+ + Y+RKKA L V K PE + P K L +
Sbjct: 127 GCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEK 186
Query: 196 DPGVQSAAVNVICELARRNP---KNYLSLAPLFFKLM--------------TSSTNNWVL 238
+ GV +V ++ E+ R+P ++ L P +++ + ++ ++
Sbjct: 187 NHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQ 246
Query: 239 IKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAM-----SLLYECVNTVIAVLISLSSG 293
++I++L L + + + + L + +T ++LYE V T++ +
Sbjct: 247 VRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDI------- 299
Query: 294 MPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKD 353
+ S L + L + ++D+N++Y+ L ++ K ++T +VQ H+ I+ CL D D
Sbjct: 300 -KSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLD 358
Query: 354 ESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNY---- 409
SI+ RA++L + +V+ N+ ++K+L+ +D E D C+ +
Sbjct: 359 VSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKAD---------CASGIFLAAE 409
Query: 410 QYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLL 469
+Y + W+I ++ + G+ ++ + + + V ++ +L
Sbjct: 410 KYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKA-----IL 464
Query: 470 ASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKL 529
+Q+ ++ AAW GE+ + L E ++ V V+ +
Sbjct: 465 GDYSQQ----PLVQVAAWCIGEYGDLLVSGQCEEEEPIQ------------VTEDEVLDI 508
Query: 530 YASILQQKEQAGEAEGAQAVTQLM---------VDRLPQFV----QSADLEVQERA---S 573
S+L G A+T +M V+R+ + V S D+E+Q+RA +
Sbjct: 509 LESVLISNMSTSVTRG-YALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYN 567
Query: 574 CILQLVKHIQKLQAKDVPVAEEVSALFAGEL----NPVAPKAQKKVPVPEGLDLDAWINE 629
+ + H++ + +PV E+V+ E+ P + P P G + N+
Sbjct: 568 ALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQAND 627
Query: 630 PLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 665
L D P P +PS A E L
Sbjct: 628 LLDLLGGNDITPVI------PTAPTSKPSSAGGELL 657
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 167 bits (424), Expect = 4e-41
Identities = 158/699 (22%), Positives = 303/699 (43%), Gaps = 96/699 (13%)
Query: 18 LQDLVRGIRNHKE--DEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
L++L+R IR + +E + I + I+ ++++ + V KL Y+ MLGY +
Sbjct: 7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFG 66
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++ KFT KRIGYL A E DV +L TN I+ DL+ +Q+ G+AL L
Sbjct: 67 QLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTL 126
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDP 195
C + ++ RDLA ++ L+ + Y+RKKA L V K PE + P K L +
Sbjct: 127 GCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEK 186
Query: 196 DPGVQSAAVNVICELARRNP------KNYLSLAPLFFKLM--------------TSSTNN 235
+ GV +V ++ E+ R+P + L P +++ + ++
Sbjct: 187 NHGVLHTSVVLLTEMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDP 246
Query: 236 WVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAM-----SLLYECVNTVIAVLISL 290
++ ++I++L L + + + + L + +T ++LYE V T++ +
Sbjct: 247 FLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDI---- 302
Query: 291 SSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLD 350
+ S L + L + ++D+N++Y+ L ++ K ++T +VQ H+ I+ CL
Sbjct: 303 ----KSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLK 358
Query: 351 DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNY- 409
D D SI+ RA++L + +V+ N+ ++K+L+ +D E D C+ +
Sbjct: 359 DLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKAD---------CASGIFL 409
Query: 410 ---QYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSA 466
+Y + W+I ++ + G+ ++ + + + V ++
Sbjct: 410 AAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKA---- 465
Query: 467 HLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNV 526
+L +Q+ ++ AAW GE+ + L E ++ V V
Sbjct: 466 -ILGDYSQQ----PLVQVAAWCIGEYGDLLVSGQCEEEEPIQ------------VTEDEV 508
Query: 527 VKLYASILQQKEQAGEAEGAQAVTQLM---------VDRLPQFV----QSADLEVQERA- 572
+ + S+L G A+T +M V+R+ + V S D+E+Q+RA
Sbjct: 509 LDILESVLISNMSTSVTRG-YALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAV 567
Query: 573 --SCILQLVKHIQKLQAKDVPVAEEVSALFAGEL----NPVAPKAQKKVPVPEGLDLDAW 626
+ + + H++ + +PV E+V+ E+ P + P P G +
Sbjct: 568 EYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQ 627
Query: 627 INEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 665
N+ L D P P +PS A E L
Sbjct: 628 ANDLLDLLGGNDITPVI------PTAPTSKPSSAGGELL 660
>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
[Homo sapiens]
Length = 1137
Score = 164 bits (415), Expect = 4e-40
Identities = 123/510 (24%), Positives = 230/510 (45%), Gaps = 49/510 (9%)
Query: 14 FDKNLQDLVRGIR--NHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC--KLTYLQMLG 69
F L LVRGI K +E K I Q + +K + +K C +L Y +MLG
Sbjct: 32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLG 91
Query: 70 YDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129
YD S+ + I++ KR+GYLA S HE ++++L N + KDL S + +
Sbjct: 92 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVC 151
Query: 130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLK 189
+ALT +S ++ + I + H+K +R+KAVL +YK L P ++ + +
Sbjct: 152 MALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFR 211
Query: 190 EKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNN-------------- 235
+ L D D GV +A++++ + + N Y L F ++
Sbjct: 212 KALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAP 271
Query: 236 WVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTS-----AMSLLYECVNTVIAVLISL 290
W+ I+++++ G L + R + + + L + ++L+ECV+TV ++
Sbjct: 272 WLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIY--- 328
Query: 291 SSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLD 350
S ++ + + + NLKYLGL A++ +++ P H+ I++CLD
Sbjct: 329 -----PKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLD 383
Query: 351 DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQ 410
D I+ L+LLY + + +N+ IV+K++ ++ +++ L+ KI ++ +
Sbjct: 384 HPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAE----K 439
Query: 411 YITNFEWYISILVELTRLEG-TRHGHL------IAAQMLDVAIRVKAIRKFAVSQMSALL 463
Y + W+I + + + G H + + A+ D + +R +AV LL
Sbjct: 440 YAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLL 499
Query: 464 DSAHLLASSTQRNGICEVLYAAAWICGEFS 493
D ++ L +W+ GE+S
Sbjct: 500 DMENVFYPQ-------RFLQVMSWVLGEYS 522
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 149 bits (375), Expect = 2e-35
Identities = 114/483 (23%), Positives = 242/483 (50%), Gaps = 38/483 (7%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++++T K+IGYL S + +++I L N I+ DL+S + G+
Sbjct: 71 DIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGL 130
Query: 131 ALTGLSCFVTPDLARDLANDI--MTLMSHTKPYIRKKAVLIMYKVFLKYPE--SLRPAFP 186
AL ++ + ++A A +I + + T +++ A L + +++ P+ +
Sbjct: 131 ALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTS 190
Query: 187 RLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPL----FFKLMTSSTNN------- 235
R+ L D GV +AA ++I LA++NP+ + + L +++TS++ +
Sbjct: 191 RVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYY 250
Query: 236 -----WVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTS--AMSLLYECVNTVIAVLI 288
W+ +K+++L P +P + +L E L +++ S + N AVL
Sbjct: 251 FVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLF 310
Query: 289 SLSSGMPNHSASIQLCVQ---KLRILIEDSDQNLKYLGLLAMSKILKTH--PKSVQSHKD 343
S + +H + L V+ +L ++ + NL+YL L +M + + ++V++H +
Sbjct: 311 EAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIE 370
Query: 344 LILQCL-DDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIID 402
++ L ++D S+R RA+DLLY M + N +IV +++++++ A+ + R+E++ K+
Sbjct: 371 TVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETAD-YSIREEIVLKVAI 429
Query: 403 ICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSAL 462
+ +Y ++ WY+ ++ L R+ G + +++ + I ++ +A +
Sbjct: 430 LAE----KYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEA 485
Query: 463 LDS 465
L +
Sbjct: 486 LQA 488
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 144 bits (364), Expect = 4e-34
Identities = 118/513 (23%), Positives = 236/513 (46%), Gaps = 66/513 (12%)
Query: 18 LQDLVRGIRNHKED--EAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
LQDL+ IR K E + I + I+ + + + + KL Y+ MLGY +
Sbjct: 8 LQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFG 67
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++S+FT KR+GYL A E D +L TN I+ DLS Q G+AL L
Sbjct: 68 QMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTL 127
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDP 195
S + ++ RDLA ++ L+ PY+RKKA+L + K PE P + L +
Sbjct: 128 STMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHER 187
Query: 196 DPGVQSAAVNVICELARRNP---KNYLSLAPLFFKLM--------------TSSTNNWVL 238
G+ + +I EL R+P +++ + P ++ + ++ ++
Sbjct: 188 HHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQ 247
Query: 239 IKIIKLFGALTPLEPRLGKKLIEPLTNLIHST-----SAMSLLYECVNTVIAVLISLSSG 293
++I++L L + + + L + +T + ++L+E V T++ +
Sbjct: 248 VQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDI------- 300
Query: 294 MPNHSASIQ-LCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDK 352
+A ++ L V L + +SD+N++Y+ L ++ +++++ +VQ H+ +++CL +
Sbjct: 301 --RSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRET 358
Query: 353 DESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYI 412
D S+ RAL+L +V+ N+ ++++L ++ R + + I+ + ++
Sbjct: 359 DASLSRRALELSLALVNSSNVRAMMQELQAFLESCP-PDLRADCASGIL----LAAERFA 413
Query: 413 TNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASS 472
W+I ++ + GT +R AV+ ++ L+ A L +
Sbjct: 414 PTKRWHIDTILHVLTTAGTH------------------VRDDAVANLTQLIGGAQELHAY 455
Query: 473 TQR---NGICE------VLYAAAWICGEFSEHL 496
+ R N + E ++ AAW GE+ + L
Sbjct: 456 SVRRLYNALAEDISQQPLVQVAAWCIGEYGDLL 488
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 137 bits (344), Expect = 8e-32
Identities = 118/492 (23%), Positives = 235/492 (47%), Gaps = 55/492 (11%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++K+T K+IGYL S + +++I L N I+ DL+S + +
Sbjct: 71 DIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130
Query: 131 ALTGLSCFVTPDLARDLANDIMTLM--SHTKPYIRKKAVLIMYKVFLKYPE--SLRPAFP 186
AL ++ + ++ A DI ++ + +++ A L + +++ P+ +
Sbjct: 131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTA 190
Query: 187 RLKEKLEDPDPGVQSAAVNVICELARRNP---KNYLSLAPLFFKLMTSSTNN-------- 235
R+ L D GV +AAV++I L ++NP K +SLA + SS +
Sbjct: 191 RVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYY 250
Query: 236 -----WVLIKIIKLFGALTPLEPRLGK-KLIEPLTNLI-------------HSTSAMSLL 276
W+ +K+++L P E K +L+E L ++ HS + ++L
Sbjct: 251 FVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAIL 310
Query: 277 YECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH-- 334
+E ++ +I PN ++ C Q L ++ + NL+YL L +M + +
Sbjct: 311 FETISLIIHY-----DSEPN--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFS 362
Query: 335 PKSVQSHKDLILQCL-DDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 393
++V++H D ++ L ++D S+R RA DLLY M + N +IV +++ +++ A+ R
Sbjct: 363 HEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETAD-YAIR 421
Query: 394 DELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRK 453
+E++ K+ + +Y ++ WY+ ++ L R+ G + ++L + ++
Sbjct: 422 EEIVLKVAILAE----KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQG 477
Query: 454 FAVSQMSALLDS 465
+A + L +
Sbjct: 478 YAAKTVFEALQA 489
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 137 bits (344), Expect = 8e-32
Identities = 118/492 (23%), Positives = 235/492 (47%), Gaps = 55/492 (11%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++K+T K+IGYL S + +++I L N I+ DL+S + +
Sbjct: 71 DIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130
Query: 131 ALTGLSCFVTPDLARDLANDIMTLM--SHTKPYIRKKAVLIMYKVFLKYPE--SLRPAFP 186
AL ++ + ++ A DI ++ + +++ A L + +++ P+ +
Sbjct: 131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTA 190
Query: 187 RLKEKLEDPDPGVQSAAVNVICELARRNP---KNYLSLAPLFFKLMTSSTNN-------- 235
R+ L D GV +AAV++I L ++NP K +SLA + SS +
Sbjct: 191 RVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYY 250
Query: 236 -----WVLIKIIKLFGALTPLEPRLGK-KLIEPLTNLI-------------HSTSAMSLL 276
W+ +K+++L P E K +L+E L ++ HS + ++L
Sbjct: 251 FVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAIL 310
Query: 277 YECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH-- 334
+E ++ +I PN ++ C Q L ++ + NL+YL L +M + +
Sbjct: 311 FETISLIIHY-----DSEPN--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFS 362
Query: 335 PKSVQSHKDLILQCL-DDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 393
++V++H D ++ L ++D S+R RA DLLY M + N +IV +++ +++ A+ R
Sbjct: 363 HEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETAD-YAIR 421
Query: 394 DELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRK 453
+E++ K+ + +Y ++ WY+ ++ L R+ G + ++L + ++
Sbjct: 422 EEIVLKVAILAE----KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQG 477
Query: 454 FAVSQMSALLDS 465
+A + L +
Sbjct: 478 YAAKTVFEALQA 489
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 92.4 bits (228), Expect = 2e-18
Identities = 100/476 (21%), Positives = 198/476 (41%), Gaps = 28/476 (5%)
Query: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
I E+K EL D K AV K+ +G D+S +++ M K++ YL
Sbjct: 15 IFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLM 74
Query: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 75 NYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
Query: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216
PY+RK A + + K+ + + LK+ + D +P V + AV + E+A +P
Sbjct: 135 PYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSS 194
Query: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272
N L L P + ++ N W I I+ P + R + + E +T L H+ SA
Sbjct: 195 NLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSA 254
Query: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILK 332
+ L V ++ + LS + + ++ L L+ ++ L+Y+ L ++ I++
Sbjct: 255 VVL--SAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLL-SAEPELQYVALRNINLIVQ 311
Query: 333 THPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTY 392
P+ + H+ + + ++L LD++ + S+ N+ +++ +L K T
Sbjct: 312 KRPE-ILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYATEV 365
Query: 393 RDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI- 451
+ + K + + + + E +S L++L + T+ +++ + + +K I
Sbjct: 366 DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVVQ----EAIVVIKDIF 418
Query: 452 RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507
RK+ S + L S + E A WI GE++E + LE+ L
Sbjct: 419 RKYPNKYESVIATLCENLDSLDEP----EARAAMIWIVGEYAERIDNADELLESFL 470
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 92.4 bits (228), Expect = 2e-18
Identities = 100/476 (21%), Positives = 198/476 (41%), Gaps = 28/476 (5%)
Query: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
I E+K EL D K AV K+ +G D+S +++ M K++ YL
Sbjct: 15 IFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLM 74
Query: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 75 NYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
Query: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216
PY+RK A + + K+ + + LK+ + D +P V + AV + E+A +P
Sbjct: 135 PYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSS 194
Query: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272
N L L P + ++ N W I I+ P + R + + E +T L H+ SA
Sbjct: 195 NLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSA 254
Query: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILK 332
+ L V ++ + LS + + ++ L L+ ++ L+Y+ L ++ I++
Sbjct: 255 VVL--SAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLL-SAEPELQYVALRNINLIVQ 311
Query: 333 THPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTY 392
P+ + H+ + + ++L LD++ + S+ N+ +++ +L K T
Sbjct: 312 KRPE-ILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYATEV 365
Query: 393 RDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI- 451
+ + K + + + + E +S L++L + T+ +++ + + +K I
Sbjct: 366 DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVVQ----EAIVVIKDIF 418
Query: 452 RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507
RK+ S + L S + E A WI GE++E + LE+ L
Sbjct: 419 RKYPNKYESVIATLCENLDSLDEP----EARAAMIWIVGEYAERIDNADELLESFL 470
>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
Length = 951
Score = 88.2 bits (217), Expect = 4e-17
Identities = 97/478 (20%), Positives = 198/478 (41%), Gaps = 32/478 (6%)
Query: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
I E+K EL + + AV K+ +G D+S +++ M K++ YL
Sbjct: 15 IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74
Query: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 75 NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
Query: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216
PY+RK A + + K+ + + L++ + D +P V + AV + E++ +P
Sbjct: 135 PYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNS 194
Query: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272
N L L P + ++ N W I I+ P + R + + E +T L H+ SA
Sbjct: 195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254
Query: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLR---ILIEDSDQNLKYLGLLAMSK 329
+ L + + VL+ +P S + ++KL + + + ++Y+ L ++
Sbjct: 255 VVL------SAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINL 308
Query: 330 ILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389
I++ P+ ++ + +D ++L LD++ + S+ N+ +++ +L K
Sbjct: 309 IVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYA 362
Query: 390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 449
T + + K + + + + E +S L++L + T+ +++ Q V IR
Sbjct: 363 TEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVV--QEAIVVIR-D 416
Query: 450 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507
RK+ S + L S + + A WI GE++E + LE+ L
Sbjct: 417 IFRKYPNKYESIIATLCENLDSLDEP----DARAAMIWIVGEYAERIDNADELLESFL 470
>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
isoform b [Homo sapiens]
Length = 937
Score = 88.2 bits (217), Expect = 4e-17
Identities = 97/478 (20%), Positives = 198/478 (41%), Gaps = 32/478 (6%)
Query: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
I E+K EL + + AV K+ +G D+S +++ M K++ YL
Sbjct: 15 IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74
Query: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 75 NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
Query: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216
PY+RK A + + K+ + + L++ + D +P V + AV + E++ +P
Sbjct: 135 PYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNS 194
Query: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272
N L L P + ++ N W I I+ P + R + + E +T L H+ SA
Sbjct: 195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254
Query: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLR---ILIEDSDQNLKYLGLLAMSK 329
+ L + + VL+ +P S + ++KL + + + ++Y+ L ++
Sbjct: 255 VVL------SAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINL 308
Query: 330 ILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389
I++ P+ ++ + +D ++L LD++ + S+ N+ +++ +L K
Sbjct: 309 IVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYA 362
Query: 390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 449
T + + K + + + + E +S L++L + T+ +++ Q V IR
Sbjct: 363 TEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVV--QEAIVVIR-D 416
Query: 450 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507
RK+ S + L S + + A WI GE++E + LE+ L
Sbjct: 417 IFRKYPNKYESIIATLCENLDSLDEP----DARAAMIWIVGEYAERIDNADELLESFL 470
>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 82.8 bits (203), Expect = 2e-15
Identities = 121/534 (22%), Positives = 226/534 (42%), Gaps = 65/534 (12%)
Query: 43 IKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIE-VMSASKFTFKRIGYL----- 96
+K +L++ ++ K A+ K+ + + G + II V+ T K++ +
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 97 ----AASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIM 152
+ HE ++L + RKDL P+++ G L L +L L I
Sbjct: 86 PKTTPDGRLLHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIR 141
Query: 153 TLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEK--LEDPDPGVQSAAVNVICEL 210
+ H Y+R+ AVL +Y ++ + E L P P L + + D + A ++
Sbjct: 142 ACLEHRHSYVRRNAVLAIYTIYRNF-EHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHA 200
Query: 211 ARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHST 270
+ +YLS + + + + I++L + P + I + NL+ S+
Sbjct: 201 DQDRALDYLSTC----IDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSS 256
Query: 271 SAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI 330
S ++ YE T L++LSS A+ Q + ++I++SD N+K + L + +
Sbjct: 257 SP-AVKYEAAGT----LVTLSSAPTAIKAAAQCYID---LIIKESDNNVKLIVLDRLIE- 307
Query: 331 LKTHPKSVQSHKDL---ILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKA 387
LK HP + +DL IL+ L D +R + L L +VS +N+ E+V L V K
Sbjct: 308 LKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKT 367
Query: 388 ------EGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441
E T +LL + + CS N I +L+E + + AA +
Sbjct: 368 NNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAAN---VIPVLMEFL----SDNNEAAAADV 420
Query: 442 LDVAIRVKAIRKFAVSQM---SALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQE 498
L+ +AI++F +M +L+ H + S ++ A WI GE+ +E
Sbjct: 421 LEFV--REAIQRFDNLRMLIVEKMLEVFHAIKS-------VKIYRGALWILGEYCS-TKE 470
Query: 499 PHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQL 552
++ +R + +P V++ +K A L+ +E+ + VT++
Sbjct: 471 DIQSVMTEIRRSLGEIP------IVESEIKKEAGELKPEEEITVGPVQKLVTEM 518
>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 82.8 bits (203), Expect = 2e-15
Identities = 121/534 (22%), Positives = 226/534 (42%), Gaps = 65/534 (12%)
Query: 43 IKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIE-VMSASKFTFKRIGYL----- 96
+K +L++ ++ K A+ K+ + + G + II V+ T K++ +
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 97 ----AASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIM 152
+ HE ++L + RKDL P+++ G L L +L L I
Sbjct: 86 PKTTPDGRLLHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIR 141
Query: 153 TLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEK--LEDPDPGVQSAAVNVICEL 210
+ H Y+R+ AVL +Y ++ + E L P P L + + D + A ++
Sbjct: 142 ACLEHRHSYVRRNAVLAIYTIYRNF-EHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHA 200
Query: 211 ARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHST 270
+ +YLS + + + + I++L + P + I + NL+ S+
Sbjct: 201 DQDRALDYLSTC----IDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSS 256
Query: 271 SAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI 330
S ++ YE T L++LSS A+ Q + ++I++SD N+K + L + +
Sbjct: 257 SP-AVKYEAAGT----LVTLSSAPTAIKAAAQCYID---LIIKESDNNVKLIVLDRLIE- 307
Query: 331 LKTHPKSVQSHKDL---ILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKA 387
LK HP + +DL IL+ L D +R + L L +VS +N+ E+V L V K
Sbjct: 308 LKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKT 367
Query: 388 ------EGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441
E T +LL + + CS N I +L+E + + AA +
Sbjct: 368 NNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAAN---VIPVLMEFL----SDNNEAAAADV 420
Query: 442 LDVAIRVKAIRKFAVSQM---SALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQE 498
L+ +AI++F +M +L+ H + S ++ A WI GE+ +E
Sbjct: 421 LEFV--REAIQRFDNLRMLIVEKMLEVFHAIKS-------VKIYRGALWILGEYCS-TKE 470
Query: 499 PHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQL 552
++ +R + +P V++ +K A L+ +E+ + VT++
Sbjct: 471 DIQSVMTEIRRSLGEIP------IVESEIKKEAGELKPEEEITVGPVQKLVTEM 518
>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
Length = 953
Score = 82.8 bits (203), Expect = 2e-15
Identities = 121/534 (22%), Positives = 226/534 (42%), Gaps = 65/534 (12%)
Query: 43 IKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIE-VMSASKFTFKRIGYL----- 96
+K +L++ ++ K A+ K+ + + G + II V+ T K++ +
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 97 ----AASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIM 152
+ HE ++L + RKDL P+++ G L L +L L I
Sbjct: 86 PKTTPDGRLLHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIR 141
Query: 153 TLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEK--LEDPDPGVQSAAVNVICEL 210
+ H Y+R+ AVL +Y ++ + E L P P L + + D + A ++
Sbjct: 142 ACLEHRHSYVRRNAVLAIYTIYRNF-EHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHA 200
Query: 211 ARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHST 270
+ +YLS + + + + I++L + P + I + NL+ S+
Sbjct: 201 DQDRALDYLSTC----IDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSS 256
Query: 271 SAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI 330
S ++ YE T L++LSS A+ Q + ++I++SD N+K + L + +
Sbjct: 257 SP-AVKYEAAGT----LVTLSSAPTAIKAAAQCYID---LIIKESDNNVKLIVLDRLIE- 307
Query: 331 LKTHPKSVQSHKDL---ILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKA 387
LK HP + +DL IL+ L D +R + L L +VS +N+ E+V L V K
Sbjct: 308 LKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKT 367
Query: 388 ------EGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441
E T +LL + + CS N I +L+E + + AA +
Sbjct: 368 NNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAAN---VIPVLMEFL----SDNNEAAAADV 420
Query: 442 LDVAIRVKAIRKFAVSQM---SALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQE 498
L+ +AI++F +M +L+ H + S ++ A WI GE+ +E
Sbjct: 421 LEFV--REAIQRFDNLRMLIVEKMLEVFHAIKS-------VKIYRGALWILGEYCS-TKE 470
Query: 499 PHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQL 552
++ +R + +P V++ +K A L+ +E+ + VT++
Sbjct: 471 DIQSVMTEIRRSLGEIP------IVESEIKKEAGELKPEEEITVGPVQKLVTEM 518
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 79.3 bits (194), Expect = 2e-14
Identities = 93/377 (24%), Positives = 156/377 (41%), Gaps = 39/377 (10%)
Query: 579 VKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESED 638
+K ++K + + V V E+ E V + +K+ EG + + E E E
Sbjct: 444 IKVVEKSEKETVIVEEQTEETQVTE--EVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET 501
Query: 639 ERPRAVFHEEEQRRPKHRPSEADEEELARRREAR--KQEQANNPFYIKS---SPSPQKRY 693
+ P A EE P+ +EE EA+ ++E+A +P +KS + SP K
Sbjct: 502 KSPPA----EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 694 QDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKG 753
+P P + + P +V + K EE + + +K + KE+ K
Sbjct: 558 AKSPPEAKSPEKE-EAKSPAEVKSPEKAKSPAK-EEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 754 KRRHSSLPTE--SDEDIAPAQQVDIVTEE---MPENAL-PSDEDDKDPNDPYRALDIDLD 807
S + E S ++ ++ T+E PE A P E+ K P + +
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675
Query: 808 KP------------LADSEKLPIQKH-RNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK 854
P + K P+++ ++ E +KSP K+ +K+K P K+E K EK
Sbjct: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735
Query: 855 ERD--KEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 912
+ KE+ K EK KSP+ K K E +T K++++ E A PV +
Sbjct: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV-----K 790
Query: 913 EEQLPPESSYSLLAENS 929
EE PE + S L E++
Sbjct: 791 EEVKSPEKAKSPLKEDA 807
Score = 73.6 bits (179), Expect = 1e-12
Identities = 84/347 (24%), Positives = 150/347 (43%), Gaps = 44/347 (12%)
Query: 605 NPVAPKAQKKV--PVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADE 662
+P K+ +K PV E A P+ + E + P V E+ + P +++ E
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE---EAKSPAEVKSPEKAKSPTKEEAKSPE 650
Query: 663 EELA-RRREARKQEQANNPFYIKS-----SPSPQKRYQDTPGVEHIPVVQIDLSV----- 711
+ + + EA+ E+A +P ++ + SP K +P PV + S
Sbjct: 651 KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS 710
Query: 712 PLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPA 771
P+K ++EE + +K + + + + ++ K + +L +S E PA
Sbjct: 711 PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Query: 772 -QQVDIVTEEMPENAL-PSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKS 829
++ ++ PE A P E+ K P PL + K P ++ E KS
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKA--------KSPLKEDAKAPEKEIPKKEEVKS 822
Query: 830 P--EKDVPMVEKKSKKPKKKEKKH-----KEKERDKEKKKEKEKKKSPKPKKKKHR---- 878
P E++ P K + PKK E++ K +E+ KK+E KK++PKPK ++ +
Sbjct: 823 PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV 882
Query: 879 -KEKEERTKGKK---KSKKQPPGSEEAAGEPVQNGAPEEEQLPPESS 921
K KE + + KK + KK+ P E+ A V+ +E+ P E +
Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE---VKEDAKPKEKT 926
Score = 69.7 bits (169), Expect = 2e-11
Identities = 68/290 (23%), Positives = 118/290 (40%), Gaps = 25/290 (8%)
Query: 610 KAQKKVPVPE-GLDLDAWINEPLSDSESEDERPRAVFHE-------EEQRRPKHRPSEAD 661
K+ +K PE LD E + ++ E P F E EE + P+ S
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 662 EEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMS 721
E+ A +E K+E+ +P +K PQ+ P + + K P P +
Sbjct: 805 EDAKAPEKEIPKKEEVKSP--VKEEEKPQEVKVKEPPKK---------AEEEKAPATPKT 853
Query: 722 DQYVKLEEERRHRQKLEKDKRRKKRK---EKEKKGKRRHSSLPTESDEDIAPAQQVDIVT 778
++ ++E +++ K K +K++ EK K+ K E + + ++
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 779 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE 838
E+ E+A P ++ + +P A + KP E P +K E +K PE + P E
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE-EKPKTE 972
Query: 839 KKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGK 888
K+K+ K KE + K +K EK K K + +++ KGK
Sbjct: 973 AKAKEDDK--TLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 68.9 bits (167), Expect = 3e-11
Identities = 85/338 (25%), Positives = 142/338 (42%), Gaps = 40/338 (11%)
Query: 629 EPLSDSESEDERPRAVFHEEEQRRPKHR----PSEADEEELAR---RREARK-------- 673
E S + E + P V E+ + P P+EA E A+ + EA+
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 674 QEQANNPFYIKS---SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEE 730
+E+A +P +KS + SP K +P P + + P K ++ K E+
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE-EAKSPEKAKSPVKAE--AKSPEK 679
Query: 731 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM--PENAL-P 787
+ K E K + +++ K + +E +P + V EE PE A P
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 788 SDEDDKDPN---DPYRALDIDLDKPLADS---EKLPIQKHRNTETSKSPEKDVPMVEKKS 841
E+ K P P +A +D+ P A + E+ + E +KSP K+ +K+
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 842 KKPKKKEKKHKEKERDKEKK-----KEKEKKKSPKPKKKKHRKEKEE-----RTKGKKKS 891
K P K++ K EKE K+++ KE+EK + K K+ + E+E+ +T+ KK S
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 892 KKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENS 929
KK+ +EA V+ + P ES E +
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Score = 67.8 bits (164), Expect = 6e-11
Identities = 81/345 (23%), Positives = 152/345 (44%), Gaps = 43/345 (12%)
Query: 605 NPVAPKAQK----KVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEA 660
+PV +A+ K PV E P+ + E+ ++ +EE + P+ S
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV-KEEAKTPEKAKSPV 740
Query: 661 DEEELARRREARKQEQANNPFYIKS--SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGL 718
EE A+ E K + +KS + +P K +P + + + +K P
Sbjct: 741 KEE--AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 719 PMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPA-----QQ 773
S +K + + ++ +K++ + KE+EK + + P +++E+ APA ++
Sbjct: 799 AKSP--LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
Query: 774 VDIVTEEMPENALPSD--EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPE 831
D EE P+ P E+ K+P ++KP + ++ + + +PE
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPA---------VEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 832 KDVPM-VE-KKSKKPKKKE---KKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEK----E 882
K+ P VE K+ KPK+K KK + + KE K EKK++ P+KK ++EK E
Sbjct: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA-APEKKDTKEEKAKKPE 966
Query: 883 ERTKGKKKSKK------QPPGSEEAAGEPVQNGAPEEEQLPPESS 921
E+ K + K+K+ + P +A + +++ PPE +
Sbjct: 967 EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKA 1011
Score = 66.6 bits (161), Expect = 1e-10
Identities = 68/302 (22%), Positives = 121/302 (40%), Gaps = 36/302 (11%)
Query: 630 PLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSP 689
P+ E+ ++ E + K + +E + + ++ +E+A +P + + SP
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP---EKAKSP 725
Query: 690 QKRYQDTPGVEHIPVVQIDLSV-----PLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRK 744
K TP PV + S P K L + K + R +K +
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 745 KRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDP-NDPYRALD 803
K KE+ + P + D + PE +P E+ K P + + +
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDA-------------KAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 804 IDLDKP--LADSEKLPI----QKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 857
+ + +P A+ EK P ++ ++++ ++P+K+ P KPK +EKK E+
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP-------KPKVEEKKEPAVEKP 885
Query: 858 KEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLP 917
KE K E KK+ + KKK EKE K + K +P E A + + +E P
Sbjct: 886 KESKVE-AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP 944
Query: 918 PE 919
E
Sbjct: 945 AE 946
Score = 57.8 bits (138), Expect = 6e-08
Identities = 57/247 (23%), Positives = 101/247 (40%), Gaps = 24/247 (9%)
Query: 698 GVEHIPVVQIDLSVPL--KVPGLPMSDQYVKLEEERRHRQKL------EKDKRRKKRKEK 749
G+ IP V + V K+ + S++ + EE+ ++ E++K K+ + K
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484
Query: 750 EKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKP 809
E++G + E + PA++ +E P E+ K P + + P
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS---PVKEEAKSPAEAKSPEKEEAKSP 541
Query: 810 LA----DSEKLPIQKH-RNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEK 864
+ K P ++ ++ +KSPEK+ + K P+K + KE+ + + K
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601
Query: 865 EKKKSPKPKKKKHRKEKEERTKGKKKS--------KKQPPGSEEAAGEPVQNGAPEEEQL 916
EK KSP ++ K E + K + KS K + P EEA +EE
Sbjct: 602 EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 917 PPESSYS 923
PE + S
Sbjct: 662 SPEKAKS 668
Score = 56.2 bits (134), Expect = 2e-07
Identities = 51/237 (21%), Positives = 94/237 (39%), Gaps = 22/237 (9%)
Query: 707 IDLSVPLKVPGLPMSDQYVKLEEERRHR--QKLEKDK------------RRKKRKEKEKK 752
I S+P +P +P ++K++ E + + +K EK+ + +E+EK+
Sbjct: 418 IPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKE 477
Query: 753 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD 812
K +E+ A + + + E A P +++ K P + P +
Sbjct: 478 AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP-EKEAKSPVKEEAKSPAEAKSPEKE 536
Query: 813 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKP 872
K P + KSPEK ++++K P + + KE+ + + K EK KSP
Sbjct: 537 EAKSPAEV-------KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589
Query: 873 KKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENS 929
++ K E + K K K++ EA + E PE + S E +
Sbjct: 590 EEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA 646
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 70.5 bits (171), Expect = 9e-12
Identities = 75/261 (28%), Positives = 116/261 (44%), Gaps = 32/261 (12%)
Query: 687 PSPQKRYQDTPGVE---HIPVVQIDLSVPLKVPG---LPMSDQYVKLEEERRHRQKLE-- 738
P +Y G+E H+ ++ L+ + G P+ Q KL++ R+ L+
Sbjct: 490 PGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQ-TKLKQRADSRESLKPA 548
Query: 739 ------KDKRRKKRKEKEKKGKRRHSSLP--TESDEDIAPAQQVDIVTEEMP---ENALP 787
K R++ ++E + K H P ES E + + I TE P E +P
Sbjct: 549 AKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVP 608
Query: 788 SDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE---KKSKKP 844
S E+ KP A EK ++ + K EK+ P E K+ K P
Sbjct: 609 SKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTP 668
Query: 845 KKKEKKHKEKERDKEKKKE--KEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA 902
KKE+K K++E KE KKE KE+KK PK + KK KE + + KK+ KK+ E+
Sbjct: 669 IKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEK-- 726
Query: 903 GEPVQNGAPEEEQLPPESSYS 923
EP + E ++LP ++ S
Sbjct: 727 -EPKK----EIKKLPKDAKKS 742
Score = 62.4 bits (150), Expect = 2e-09
Identities = 66/262 (25%), Positives = 110/262 (41%), Gaps = 27/262 (10%)
Query: 662 EEELARRREARKQ-EQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPM 720
+ +L +R ++R+ + A P KS K ++TP V + V+ V K +
Sbjct: 532 QTKLKQRADSRESLKPAAKPLPSKSVRKESK--EETPEVTKVNHVEKPPKVESKEKVMVK 589
Query: 721 SDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEE 780
D+ +K E + +K K + E K+ P + E + ++
Sbjct: 590 KDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK 649
Query: 781 MPENALPSDE----DDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPM 836
E P E +DK P +KP + K ++K E K P+K+V
Sbjct: 650 KEEKEKPKKEVAKKEDKTPIKKE-------EKPKKEEVKKEVKKEIKKEEKKEPKKEV-- 700
Query: 837 VEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQP- 895
KK PK+ +K+ K++E+ + KK+EKE KK K K +K ++ KK + +P
Sbjct: 701 --KKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPK 758
Query: 896 -PGSEE-------AAGEPVQNG 909
P EE AAG+P + G
Sbjct: 759 VPKKEESVKKDSVAAGKPKEKG 780
Score = 48.5 bits (114), Expect = 4e-05
Identities = 54/272 (19%), Positives = 110/272 (40%), Gaps = 26/272 (9%)
Query: 642 RAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEH 701
++V E ++ P+ ++ + E + E++++ IK+ P ++ P E
Sbjct: 555 KSVRKESKEETPE--VTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE 612
Query: 702 IPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLP 761
V+ +++ P + + +++E + + + +K+++ K +KE KK
Sbjct: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKK--------- 663
Query: 762 TESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKH 821
ED P ++ + +E + + + ++ +P + + + E +K
Sbjct: 664 ----EDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKK 719
Query: 822 RNTETSKSPEKDV---PMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHR 878
+ K P+K++ P KKS P + KK + KK+E KK S K K
Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKE- 778
Query: 879 KEKEERTKGKKKSKKQPPGSEEAAGEPVQNGA 910
KGK K K+ + EA V GA
Sbjct: 779 -------KGKIKVIKKEGKAAEAVAAAVGTGA 803
Score = 45.1 bits (105), Expect = 4e-04
Identities = 62/327 (18%), Positives = 128/327 (39%), Gaps = 44/327 (13%)
Query: 612 QKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREA 671
+K+VP E + + +++ ++ D +P+A + ++ K +P + EE+ ++E
Sbjct: 604 EKEVPSKEE---PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
Query: 672 RKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEER 731
K+E IK P+K V+ ++ +K + VK E
Sbjct: 661 AKKEDKTP---IKKEEKPKKE-----------EVKKEVKKEIKKEEKKEPKKEVKKETPP 706
Query: 732 RHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDED 791
+ +K K + +K+ K++EK+ K+ LP ++ + P + P+ +
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
Query: 792 DKD------PNDPYRALDIDLDKPLADSEKLPIQKHRNTE--------TSKSPEKDVPMV 837
KD P + + I + A++ + T + P K++
Sbjct: 767 KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE 826
Query: 838 EKKSKKPKKKEKKHKEKERDK-----------EKKKEKEKKKSPKPKKKKHRKEKEERTK 886
P+ K +E + ++ E +++EK K +P + +++ E TK
Sbjct: 827 RSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTK 886
Query: 887 GKKKSKKQPPGSEEAAGEPVQNGAPEE 913
G +S + + E GE Q PEE
Sbjct: 887 GPAESPDEGITTTEGEGECEQ--TPEE 911
Score = 42.4 bits (98), Expect = 0.003
Identities = 86/440 (19%), Positives = 158/440 (35%), Gaps = 115/440 (26%)
Query: 588 KDVPVAEEVSALFAG----ELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRA 643
K+VP EE S + A + V PKA K+ V + + D + E E+P+
Sbjct: 605 KEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP------EDKKEEKEKPKK 658
Query: 644 VFHEEEQRRPKHRPSEADEEELAR--RREARKQEQANNPFYIKSSPSPQ----------- 690
++E + P + + +EE+ + ++E +K+E+ +K P+
Sbjct: 659 EVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEK 718
Query: 691 ---KRYQDTPG--VEHIPVVQIDLSVPLKV--------PGLPMSDQYVKLEEERRHRQKL 737
K+ + P ++ +P S PL P +P ++ VK + + K
Sbjct: 719 KEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPK- 777
Query: 738 EKDKRRKKRKE--------------------------------KEKKGKRRHSSLPTESD 765
EK K + +KE KE + +R S P +
Sbjct: 778 EKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLT 837
Query: 766 EDIAP--AQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDK-----PLADSEKLPI 818
+D A++VD+ + P+ L DE+ +P A I ++ P ++
Sbjct: 838 KDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGIT 897
Query: 819 QKHRNTETSKSPEKDVPM-----------------VEKKSKKPKKKEKKHKEKERDKEKK 861
E ++PE+ P+ E+ S+ +EK E+ + E+
Sbjct: 898 TTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEED 957
Query: 862 KEKE-----KKKSPKPKKKKHRKEKEERTKGKKKS-----------------KKQPPGSE 899
E+ K SP ++ + E + + K++S K + SE
Sbjct: 958 GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
Query: 900 EAAGEPVQNGAPEEEQLPPE 919
E A E + EE+ PE
Sbjct: 1018 EEADEEDKAEDAREEEYEPE 1037
Score = 42.4 bits (98), Expect = 0.003
Identities = 44/188 (23%), Positives = 73/188 (38%), Gaps = 26/188 (13%)
Query: 759 SLPTESDEDIAPAQQVDIVTEEMPE-----NALPSDEDDKDPNDP---YRALDIDLDKPL 810
S P+++D D+ P TEE P N DE + P D Y+ +D P
Sbjct: 2153 SAPSQTDSDVPPE------TEECPSITADANIDSEDESETIPTDKTVTYKHMD---PPPA 2203
Query: 811 ADSEKLPIQKHRNTET----SKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEK 866
++ P +H + + + E+++ KK K K K KK K + K+ +
Sbjct: 2204 PVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDG 2263
Query: 867 K-----KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESS 921
K SPKP K +K R KK + ++ V+ EE+ +++
Sbjct: 2264 KSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNA 2323
Query: 922 YSLLAENS 929
+ A S
Sbjct: 2324 ANASASKS 2331
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 68.9 bits (167), Expect = 3e-11
Identities = 47/166 (28%), Positives = 85/166 (51%), Gaps = 5/166 (3%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALP 787
E+ +R R+K K +R KK K+ E+K + R E+ ++ +E E
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126
Query: 788 SDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKK 847
S E + R + ++ E+ ++ E K K V E++ K+ ++K
Sbjct: 127 SKEGKERERKEERKREERKERERKKEERE--KERERKERKKRERKQVGEKEEERKEKERK 184
Query: 848 EKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKK 893
E+K +E+ R KE+KKE+E+K+ + ++KK RK+KEER K ++K ++
Sbjct: 185 ERKKRERNR-KERKKERERKE--RRERKKERKKKEERKKERQKDRQ 227
Score = 67.8 bits (164), Expect = 6e-11
Identities = 48/194 (24%), Positives = 92/194 (47%), Gaps = 15/194 (7%)
Query: 726 KLEEERRHRQKLEKDKRRKK-RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 784
K E R ++K E++K RK+ R +KEKKG+R+ + +E E
Sbjct: 60 KKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRR----------EKENKEG 109
Query: 785 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKP 844
K+ + R ++ + K +K R + + EK+ E+K ++
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER-EKERERKERKKRER 168
Query: 845 KK---KEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 901
K+ KE++ KEKER + KK+E+ +K+ K +++K R+E+++ K K++ KK+ +
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQT 228
Query: 902 AGEPVQNGAPEEEQ 915
+ G E ++
Sbjct: 229 NWREKERGKRERKE 242
Score = 65.5 bits (158), Expect = 3e-10
Identities = 44/167 (26%), Positives = 82/167 (49%), Gaps = 13/167 (7%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALP 787
++E R R+K ++K K+ +EKEK+ K+ S E ++ + EE E
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 788 SDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKK 847
+E +K+ R ++ Q E K E+ ++++K +KK
Sbjct: 151 KEEREKERERKER------------KKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198
Query: 848 EKKHKE-KERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKK 893
E++ KE +ER KE+KK++E+KK + ++ + +EKE + +K+ KK
Sbjct: 199 ERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 64.7 bits (156), Expect = 5e-10
Identities = 51/220 (23%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 709 LSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKK-RKEKEKKGKRRHSSLPTESDED 767
+S P PG + + E E R K E++ RKK R+E+EK+ + R E +
Sbjct: 25 ISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKK 84
Query: 768 IAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETS 827
++ EE ++++K+ + + +K ++ R ++
Sbjct: 85 EKKGERKK---EERERKKRRREKENKEGEEKEKR-----------KKKEKKERGRTSKEG 130
Query: 828 KSPE-KDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEK----EKKKSPKPKKKKHRKEKE 882
K E K+ E++ ++ +KKE++ KE+ER + KK+E+ EK++ K K++K RK++E
Sbjct: 131 KERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRE 190
Query: 883 ERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSY 922
K +KK +++ E + +E Q ++++
Sbjct: 191 RNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Score = 37.0 bits (84), Expect = 0.11
Identities = 28/122 (22%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Query: 635 ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQ 694
E + ER + +++RR K E +E+E +R++ K+E+ K ++R +
Sbjct: 85 EKKGERKKEERERKKRRREKEN-KEGEEKE--KRKKKEKKERGRTSKEGKERERKEERKR 141
Query: 695 DTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGK 754
+ + + K Q + EEER+ +++ E+ KR + RKE++K+ +
Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Query: 755 RR 756
R+
Sbjct: 202 RK 203
>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 170
Score = 68.9 bits (167), Expect = 3e-11
Identities = 33/73 (45%), Positives = 49/73 (67%)
Query: 830 PEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKK 889
P +P E+K +K K+K+KK K+K++ K+KKK+K+KKK K KKK+ RK K +R + KK
Sbjct: 95 PLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKK 154
Query: 890 KSKKQPPGSEEAA 902
+ KK+ E A
Sbjct: 155 RKKKKKKTGNEGA 167
Score = 62.8 bits (151), Expect = 2e-09
Identities = 29/62 (46%), Positives = 45/62 (72%)
Query: 838 EKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPG 897
EK+ +K KKK+KK K+K++ K+KKK+K+KKK K K+K+ RK K ++ + KKK K G
Sbjct: 107 EKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGNEG 166
Query: 898 SE 899
++
Sbjct: 167 AK 168
Score = 60.8 bits (146), Expect = 7e-09
Identities = 29/68 (42%), Positives = 44/68 (64%)
Query: 816 LPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK 875
LP+ E K EK+ +KK KK KKK+KK K+K++ K+KKK K K+K + +KK
Sbjct: 94 LPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKK 153
Query: 876 KHRKEKEE 883
K +K+K++
Sbjct: 154 KRKKKKKK 161
Score = 59.7 bits (143), Expect = 2e-08
Identities = 27/74 (36%), Positives = 49/74 (66%)
Query: 830 PEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKK 889
P +P+ ++ KK+++K K+K++ K+KKK+K+KKK K KKKK +K+++ + K K+
Sbjct: 90 PSLHLPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKR 149
Query: 890 KSKKQPPGSEEAAG 903
K KK+ ++ G
Sbjct: 150 KRKKKRKKKKKKTG 163
Score = 59.7 bits (143), Expect = 2e-08
Identities = 29/67 (43%), Positives = 46/67 (68%), Gaps = 2/67 (2%)
Query: 838 EKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPG 897
+++ KK K+KEKK K+K+ K+KKK+K+KKK K KKKK +K K +R + +K+ KK+
Sbjct: 101 QREEKKEKEKEKKKKKKK--KKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKK 158
Query: 898 SEEAAGE 904
++ E
Sbjct: 159 KKKTGNE 165
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/77 (35%), Positives = 50/77 (64%)
Query: 816 LPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK 875
L + H + + EK+ +KK KK KKK+KK K+K++ K+KKK+K K+K + +K+
Sbjct: 92 LHLPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKR 151
Query: 876 KHRKEKEERTKGKKKSK 892
K +++K+++ G + +K
Sbjct: 152 KKKRKKKKKKTGNEGAK 168
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/70 (41%), Positives = 38/70 (54%)
Query: 806 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKE 865
L PL + +K + E K +K +KK KK KKK+KK K+K + K K+K K
Sbjct: 92 LHLPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKR 151
Query: 866 KKKSPKPKKK 875
KKK K KKK
Sbjct: 152 KKKRKKKKKK 161
Score = 45.1 bits (105), Expect = 4e-04
Identities = 22/64 (34%), Positives = 38/64 (59%)
Query: 814 EKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPK 873
EK +K + + K +K +KK KK KKK K+ ++++R ++KK++K+KKK+
Sbjct: 107 EKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGNEG 166
Query: 874 KKKH 877
K H
Sbjct: 167 AKIH 170
Score = 41.2 bits (95), Expect = 0.006
Identities = 17/47 (36%), Positives = 35/47 (74%)
Query: 710 SVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRR 756
S+ L + GLP ++ + E+E++ ++K +K K++KK+K+K+KK K++
Sbjct: 91 SLHLPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKK 137
Score = 38.5 bits (88), Expect = 0.037
Identities = 20/74 (27%), Positives = 38/74 (51%)
Query: 798 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 857
P L +K + EK +K + + K +K +KK KK K+K K+ +++++
Sbjct: 95 PLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKK 154
Query: 858 KEKKKEKEKKKSPK 871
++KKK+K + K
Sbjct: 155 RKKKKKKTGNEGAK 168
Score = 32.0 bits (71), Expect = 3.5
Identities = 12/31 (38%), Positives = 24/31 (77%)
Query: 726 KLEEERRHRQKLEKDKRRKKRKEKEKKGKRR 756
K +++++ ++K +K KR++KRK K K+ K+R
Sbjct: 125 KKKKKKKKKKKKKKKKRKRKRKRKRKRKKKR 155
Score = 31.6 bits (70), Expect = 4.5
Identities = 13/27 (48%), Positives = 22/27 (81%)
Query: 726 KLEEERRHRQKLEKDKRRKKRKEKEKK 752
K ++++R R++ K KR+KKRK+K+KK
Sbjct: 135 KKKKKKRKRKRKRKRKRKKKRKKKKKK 161
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/291 (22%), Positives = 125/291 (42%), Gaps = 46/291 (15%)
Query: 606 PVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 665
P+ ++K +P +++ + + L + E+ R E+++ + K + + +E+
Sbjct: 504 PLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKE 563
Query: 666 ARRREARKQEQANNPFYIKSSPSPQK-RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 724
+ R+ + F + P K + ++ V+ P + + D
Sbjct: 564 KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVD---------------PKVKLKDGL 608
Query: 725 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 784
V+ E+E+ KDK++ + K K+ K KR + + ED A +V
Sbjct: 609 VRKEKEKH------KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVL------ 656
Query: 785 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKP 844
P + L + L P A + ++P PEK EK +K
Sbjct: 657 -------------PPKELALPLFSP-ATASRVPAMLPSLLPVL--PEKLFEEKEKVKEKE 700
Query: 845 KKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQP 895
KKK+KK K+K+ KEK+KEK++K+ K K+++ ++EKE+ +K K +P
Sbjct: 701 KKKDKKEKKKK--KEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEP 749
Score = 47.0 bits (110), Expect = 1e-04
Identities = 48/254 (18%), Positives = 108/254 (42%), Gaps = 57/254 (22%)
Query: 709 LSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDI 768
+S P P + ++ KL ++KL+K+ + K +K+++++ + R E D++
Sbjct: 497 VSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER------EKDKNK 550
Query: 769 APAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSK 828
+++ D V E+ + E ++ P++ L + AD K I++ + +
Sbjct: 551 DKSKEKDKVKEKEKDK-----ETGRETKYPWKEF---LKEEEADPYKFKIKEFEDVDPKV 602
Query: 829 SPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKE------KEKKKSPKPK--------- 873
+ + EK+ K KKK+++ +K++DK +K++ ++K K+P P
Sbjct: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELA 662
Query: 874 ----------------------------KKKHRKEKEERTKGKKKSKKQPPGSEEAAGEP 905
++K + +++E+ K KK+ KK+ +E +
Sbjct: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE 722
Query: 906 VQNGAPEEEQLPPE 919
+ E E+ E
Sbjct: 723 REKEKREREKREKE 736
Score = 45.4 bits (106), Expect = 3e-04
Identities = 48/202 (23%), Positives = 77/202 (38%), Gaps = 55/202 (27%)
Query: 774 VDIVTEEMPENALPSDEDDKDPNDPYRALDI-------DLDKPLADSEKLPIQKHRNTET 826
+D +E+ A + PN PY + L K + KLP + E
Sbjct: 466 MDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLP----SSVEV 521
Query: 827 SKSPEKDVPMVEKKSKKPKKKEK---KHKEKERDKEKKKEKEKKKS-------------- 869
K +K++ KK +K + +E+ K+K+K ++K+K KEKEK K
Sbjct: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
Query: 870 ------------------PKPK---------KKKHRKEKEERTKGKKKSKKQPPGSEEAA 902
PK K K+KH+ +K++R KGKK K+ +
Sbjct: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDK 641
Query: 903 GEPVQNGAPEEEQLPPESSYSL 924
G + AP + P +L
Sbjct: 642 GREDKMKAPAPPLVLPPKELAL 663
Score = 40.8 bits (94), Expect = 0.007
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 20/185 (10%)
Query: 827 SKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTK 886
+KS +E KS PK K K ++ K K + P + KE+++
Sbjct: 253 AKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSP 312
Query: 887 GKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYS--LLAENSYVK--MTCDIRGSLQ 942
G+ KS K P + P PE P ++ S + E VK T G L
Sbjct: 313 GRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLN 372
Query: 943 EDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEA 1002
++Q A+V + K +E S+ D++ AR + + P PF+ G +E
Sbjct: 373 SENQPKKAVVAD-------KTIEASI-DAVIAR-------ACAEREPDPFEFSSGSESEG 417
Query: 1003 QYVFT 1007
+FT
Sbjct: 418 D-IFT 421
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 67.4 bits (163), Expect = 7e-11
Identities = 56/283 (19%), Positives = 122/283 (43%), Gaps = 51/283 (18%)
Query: 635 ESEDERPRAVFHEEEQRRPKHRPSEADEEELAR-RREARKQEQANNPFYIKSSPSPQKRY 693
++E ER R E +++ ++R E + E+ + RRE +Q + N + S ++R
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 694 QDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKG 753
++ + + E ER+ + E+D++RK +E+EK+
Sbjct: 214 RE---------------------------RETETETERKRQTDRERDRQRKTEREREKQA 246
Query: 754 KRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDED-DKDPNDPYRALDIDLDKPLAD 812
+R +S + TE E D D D+D R D +
Sbjct: 247 ERERAS---------------ERETERDKERERERDRDRDRDRRQKERERQTDRKR---- 287
Query: 813 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKP 872
+ ++ R TE + +++ ++++K +++ ++ +E+ER +E ++++EK++ K
Sbjct: 288 --QRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKR 345
Query: 873 KKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
K++ + R G ++ ++Q E E + A E E+
Sbjct: 346 KRQTEMDRERNRQTG-REGRRQAERERERERERDRQSAREREE 387
Score = 67.0 bits (162), Expect = 1e-10
Identities = 50/289 (17%), Positives = 125/289 (43%), Gaps = 10/289 (3%)
Query: 633 DSESEDERP--RAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQ 690
D+E E ER R + E+ R K R E + +E R R++E + + +
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 691 KRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKE 750
+ + E + K ++ + E ER ++ E+DK R++ ++++
Sbjct: 214 RERETETETERKRQTDRERDRQRKTE----REREKQAERERASERETERDKERERERDRD 269
Query: 751 KKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPL 810
+ RR ++D + D TE E + + + R + + ++
Sbjct: 270 RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERER 329
Query: 811 ADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSP 870
+ +K R + + E D + ++ +++ ++ +E+ER+++++ +E+++
Sbjct: 330 QRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389
Query: 871 KPKKKKHRKEKEERTK----GKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+ + + +KE+E +T+ G+++++KQ ++ E + E E+
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438
Score = 61.6 bits (148), Expect = 4e-09
Identities = 34/172 (19%), Positives = 85/172 (49%), Gaps = 3/172 (1%)
Query: 726 KLEEERRHRQKLEK--DKRRKKRKEKEKKGKR-RHSSLPTESDEDIAPAQQVDIVTEEMP 782
K E RR +++ E+ D++R++R+EK++ KR RH + +++ + +
Sbjct: 60 KERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREK 119
Query: 783 ENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 842
E + + + + R D D + +K R +T + ++ +K +
Sbjct: 120 ERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKER 179
Query: 843 KPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
+ +K ++ +E+ER +EK+ + E + S + ++++ +E E T+ K+++ ++
Sbjct: 180 EREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/263 (20%), Positives = 125/263 (47%), Gaps = 22/263 (8%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 692
++E+E ER R + ++ R + R +E + E+ A R A ++E + K + R
Sbjct: 217 ETETETERKR----QTDRERDRQRKTEREREKQAERERASERETERD----KERERERDR 268
Query: 693 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKK 752
+D + Q D + D+ + + ER+ ++ E+++ RK+ +E+E++
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTE----RDRETERKRERQRERERERERNRKRERERERE 324
Query: 753 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLA- 811
+ R TE D + ++ TE E + + + + R + + D+ A
Sbjct: 325 -RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 812 --DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKS 869
+ + + R E + EKD +++++K +++EK +E ER +E+ +E+EK+K
Sbjct: 384 EREERERDRDRDRQKERERQTEKDRDG-QRETEKQREREKD-RESERGRERGREREKQKG 441
Query: 870 PKPKKKKHRKEKEERTKGKKKSK 892
+++ R+ + +R G+++ +
Sbjct: 442 ----RERDRERQTDRQAGRQRKR 460
Score = 54.3 bits (129), Expect = 7e-07
Identities = 36/188 (19%), Positives = 86/188 (45%), Gaps = 4/188 (2%)
Query: 729 EERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPS 788
E RR + + K R ++R+ +K + R + + + +Q + E E
Sbjct: 80 ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139
Query: 789 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 848
D + R D + ++ + Q RN + + EK+ +++ ++ +++E
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKN---RQERRERERQRE 196
Query: 849 KKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE-EAAGEPVQ 907
K++K ++R E+ +E+E+++ + + ++ R+ ER + +K +++ +E E A E
Sbjct: 197 KENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERET 256
Query: 908 NGAPEEEQ 915
E E+
Sbjct: 257 ERDKERER 264
Score = 53.9 bits (128), Expect = 9e-07
Identities = 38/219 (17%), Positives = 100/219 (45%), Gaps = 12/219 (5%)
Query: 700 EHIPVVQIDLSVPL----KVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKR 755
+ + + +++++PL + PG S + L + H+ D+ R ++KE+E++ ++
Sbjct: 11 DQLGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQA--HKDADGDDRERNRQKERERRREK 68
Query: 756 RHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEK 815
R + T+ + + + E +++ + R D + D+
Sbjct: 69 RQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE------RQTDRERDRQREKERN 122
Query: 816 LPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK 875
++ R TE +D ++ ++ ++ +K +E++ D+E++++ E+ + + +++
Sbjct: 123 RQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERERE 182
Query: 876 KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEE 914
K+R+E+ ER + ++K K E E + E E
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERGRERERERETETE 221
Score = 46.6 bits (109), Expect = 1e-04
Identities = 27/138 (19%), Positives = 65/138 (47%), Gaps = 1/138 (0%)
Query: 783 ENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 842
E +P D + P L + D++ +++R E + EK E K
Sbjct: 19 EVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK 78
Query: 843 KPKKKEK-KHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 901
+ +++EK +H++++R +E+++++EK++ + +++ R+ ++ER + K++ ++ E
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 902 AGEPVQNGAPEEEQLPPE 919
E Q E
Sbjct: 139 RDRQTDGQRERERQRDAE 156
Score = 33.9 bits (76), Expect = 0.92
Identities = 39/192 (20%), Positives = 75/192 (39%), Gaps = 17/192 (8%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELAR-----RREARKQEQANNPFYIKSSP 687
+ E E +R E+E+ R + R +E D E + RR+A ++ + +S+
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 688 SPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRK 747
++R +D D + D + E++R + E ++ R++ +
Sbjct: 384 EREERERDRDR---------DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR 434
Query: 748 EKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRAL--DID 805
E+EK+ K R ++D ++ + P S DPN P R +
Sbjct: 435 EREKQ-KGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSS 493
Query: 806 LDKPLADSEKLP 817
+ P A S + P
Sbjct: 494 PEDPKAASTRFP 505
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 67.0 bits (162), Expect = 1e-10
Identities = 40/168 (23%), Positives = 89/168 (52%), Gaps = 11/168 (6%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALP 787
E E++ ++ E+D+ R++ ++++++ +R TE D D Q + TE +
Sbjct: 126 EREKQKGRERERDRGRERERDRDREKERERQ---TEKDRD----GQRETETERERDRERE 178
Query: 788 SDEDDKDPNDPYRALDIDLDKPL-ADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK 846
++ + D R D + ++ D E+ + R T+T + E D + ++ ++
Sbjct: 179 KQKERETERDRDRQRDTEKERERQTDRER---DRQRKTQTERQRETDREGERETDRRRER 235
Query: 847 KEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
+ + + KERD+E+ +++E+KK K ++KK RKEK++ K ++ K++
Sbjct: 236 QRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 35/173 (20%), Positives = 83/173 (47%)
Query: 722 DQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM 781
D+ K + ERR ++K R ++++ + ++ + R E + D ++ D E+
Sbjct: 93 DRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKE 152
Query: 782 PENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 841
E D D + + R D + +K + + R+TE + + D ++
Sbjct: 153 RERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRK 212
Query: 842 KKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
+ +++ + +E ER+ ++++E+++ + ++ + R KEER K +KK +K+
Sbjct: 213 TQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKK 265
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/147 (27%), Positives = 70/147 (47%), Gaps = 10/147 (6%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEKKGKR-RHSSLPTESDEDIAPAQQVDIVTEEMPENAL 786
E+ER + + ++D +R+ E+E+ +R + TE D D +Q D TE+ E
Sbjct: 150 EKERERQTEKDRDGQRETETERERDREREKQKERETERDRD----RQRD--TEKERERQT 203
Query: 787 PSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS-KKPK 845
+ D + R + D + + Q+ R+ + E+D KK KK +
Sbjct: 204 DRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKER 263
Query: 846 KKEKKHKEKE--RDKEKKKEKEKKKSP 870
KKE+K K+KE R ++KK++ + SP
Sbjct: 264 KKERKEKKKEEKRREDKKRKWGEGISP 290
Score = 38.9 bits (89), Expect = 0.028
Identities = 18/73 (24%), Positives = 41/73 (56%), Gaps = 5/73 (6%)
Query: 832 KDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKE-----ERTK 886
KD +++ ++ + +EK KE++RD+++ +E+ +K+ + + K+ E ER K
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129
Query: 887 GKKKSKKQPPGSE 899
K + +++ G E
Sbjct: 130 QKGRERERDRGRE 142
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/78 (23%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 838 EKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPG 897
E+ + + +E++ KEKE ++ + +EK+ + +++K + + ER +G+++ + +
Sbjct: 91 ERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDRE 150
Query: 898 SE-EAAGEPVQNGAPEEE 914
E E E ++G E E
Sbjct: 151 KERERQTEKDRDGQRETE 168
Score = 33.5 bits (75), Expect = 1.2
Identities = 32/162 (19%), Positives = 72/162 (44%), Gaps = 10/162 (6%)
Query: 757 HSSLPTESDEDIAPAQ--QVDIVTEEMPEN-ALPSDEDDKDPNDPYRALDIDLDKPLADS 813
HSSL T E P + + ++E P + L D D +D R D +K +
Sbjct: 33 HSSLGTLWVEVTIPLDFSRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREK----T 88
Query: 814 EKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPK 873
EK + + + EK+ + K+ + + + +EK++ +E+++++ +++ +
Sbjct: 89 EKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERE---R 145
Query: 874 KKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+ KE+E +T+ + +++ E E + E E+
Sbjct: 146 DRDREKERERQTEKDRDGQRETETERERDREREKQKERETER 187
Score = 32.7 bits (73), Expect = 2.0
Identities = 27/137 (19%), Positives = 58/137 (42%), Gaps = 3/137 (2%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEAD---EEELARRREARKQEQANNPFYIKSSPSP 689
D E ER R E E++ K R + + E E R RE +K+ + +
Sbjct: 138 DRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEK 197
Query: 690 QKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEK 749
++ Q + Q + G +D+ + + +R ++ ++++ RK+ ++K
Sbjct: 198 ERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK 257
Query: 750 EKKGKRRHSSLPTESDE 766
E+K +R+ + +E
Sbjct: 258 ERKKERKKERKEKKKEE 274
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 67.0 bits (162), Expect = 1e-10
Identities = 42/167 (25%), Positives = 83/167 (49%), Gaps = 5/167 (2%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPT-ESDEDIAPAQQVDIVTEEMPENAL 786
+E +R R K EK KR+K+ + KE++ KR+ E E ++ + E +
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR 111
Query: 787 PSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK 846
+ K+ + R ++ K +K R E + + KK ++ KK
Sbjct: 112 RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK 171
Query: 847 KEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKK 893
+E+ KE+++++E+K+ +E+KK ++KK R++K+ER K +K ++
Sbjct: 172 RERNRKERKKERERKERRERKK----ERKKERRKKKERKKDRKTDRQ 214
Score = 66.6 bits (161), Expect = 1e-10
Identities = 43/179 (24%), Positives = 91/179 (50%), Gaps = 11/179 (6%)
Query: 719 PMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVT 778
P + + + ++ERR R+K ++++ +++++E+ KK K++ + + ++
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87
Query: 779 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPE-KDVPMV 837
E + ++ K R + +K +K R E + E K
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGR--------RERKKKKERKERERENKQRRERKRKKRR 139
Query: 838 EKKSKKPKKKEKKH--KEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
+KK +K +K+EK+ +E++R K KK+E+EKK+ K++K +E++ER + KK+ KK+
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
Score = 50.1 bits (118), Expect = 1e-05
Identities = 19/73 (26%), Positives = 48/73 (65%)
Query: 828 KSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKG 887
K E++ E++ K+ +K++K+ K++ER + ++E++KKK K +++++++ +E + K
Sbjct: 78 KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKK 137
Query: 888 KKKSKKQPPGSEE 900
++K K++ E
Sbjct: 138 RRKKKRRKERKRE 150
Score = 40.4 bits (93), Expect = 0.010
Identities = 16/53 (30%), Positives = 39/53 (73%), Gaps = 1/53 (1%)
Query: 843 KPKKKEKKHKEKERDKEKKKEKEKKKSPKPKK-KKHRKEKEERTKGKKKSKKQ 894
KP + + ++KER + +K+++E++K K ++ KK +K++++R +GK++ +K+
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR 79
Score = 31.6 bits (70), Expect = 4.5
Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query: 855 ERDKEKKKEKEKKKSPKPKKKKHRKE--KEERTKGKKKSKKQPPGSE 899
+R+ E+KKE+ +++ +K++ KE +E K KKK KK+ G E
Sbjct: 31 QRESERKKERREREK---RKREREKERKRERGKKEKKKRKKRERGKE 74
>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
Length = 237
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 20/181 (11%)
Query: 728 EEERRHRQKL----EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPE 783
+E +HR+KL E ++++RK+KEKK R+SS + S + + + ++ E
Sbjct: 61 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSS------SDSEDE 114
Query: 784 NALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK- 842
+ K N +++ + + + +DS K ++K + ++ EKD+ + KK K
Sbjct: 115 DKKQGKRRKKKKNRSHKSSESSMSETESDS-KDSLKKKKKSKDGTEKEKDIKGLSKKRKM 173
Query: 843 ----KPKKKEK----KHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
KP E ++ E+ R K+KK +E++K+ + KKK + +K + K KK +
Sbjct: 174 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 233
Query: 895 P 895
P
Sbjct: 234 P 234
Score = 36.2 bits (82), Expect = 0.18
Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 20/106 (18%)
Query: 806 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK-------ERDK 858
L++P E++ Q + + SK+ + EK ++ KK+ +KH+EK K
Sbjct: 24 LNRPRPTWEEVKEQLEKKKKGSKALAE---FEEKMNENWKKELEKHREKLLSGSESSSKK 80
Query: 859 EKKKEKEKKKSPK----------PKKKKHRKEKEERTKGKKKSKKQ 894
++K+KEKKKS + E E++ +GK++ KK+
Sbjct: 81 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK 126
Score = 34.3 bits (77), Expect = 0.70
Identities = 37/162 (22%), Positives = 68/162 (41%), Gaps = 27/162 (16%)
Query: 808 KPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKER----------- 856
K LA+ E+ + ++ E K EK + E SKK ++K+K+ K+ R
Sbjct: 46 KALAEFEE-KMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDS 104
Query: 857 --------DKEKKKEK-EKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQ 907
D++KK+ K KKK + K E + K KK+ + E
Sbjct: 105 SSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDI 164
Query: 908 NGAPEEEQLPPES---SYSLLAENSYVKMTCDIRGSLQEDSQ 946
G ++ ++ E S L+E+ Y++ ++R ++ S+
Sbjct: 165 KGLSKKRKMYSEDKPLSSESLSESEYIE---EVRAKKKKSSE 203
Score = 33.9 bits (76), Expect = 0.92
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 13/127 (10%)
Query: 632 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 691
SDSE ED++ +++ R K S E E + +K+ K S +
Sbjct: 109 SDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK---------KKSKDGTE 159
Query: 692 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 751
+ +D G+ + + PL L S+ +EE R ++K +++ + K K+K
Sbjct: 160 KEKDIKGLSKKRKMYSE-DKPLSSESLSESEY---IEEVRAKKKKSSEEREKATEKTKKK 215
Query: 752 KGKRRHS 758
K ++HS
Sbjct: 216 KKHKKHS 222
Score = 30.8 bits (68), Expect = 7.8
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 5/86 (5%)
Query: 835 PMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK-----KHRKEKEERTKGKK 889
P E+ ++ +KK+K K +EK E KK+ K ++K + +K +R K +K
Sbjct: 29 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK 88
Query: 890 KSKKQPPGSEEAAGEPVQNGAPEEEQ 915
K + S ++ + + + E++
Sbjct: 89 KKSGRYSSSSSSSSDSSSSSSDSEDE 114
>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
Length = 247
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 20/181 (11%)
Query: 728 EEERRHRQKL----EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPE 783
+E +HR+KL E ++++RK+KEKK R+SS + S + + + ++ E
Sbjct: 71 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSS------SDSEDE 124
Query: 784 NALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK- 842
+ K N +++ + + + +DS K ++K + ++ EKD+ + KK K
Sbjct: 125 DKKQGKRRKKKKNRSHKSSESSMSETESDS-KDSLKKKKKSKDGTEKEKDIKGLSKKRKM 183
Query: 843 ----KPKKKEK----KHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
KP E ++ E+ R K+KK +E++K+ + KKK + +K + K KK +
Sbjct: 184 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
Query: 895 P 895
P
Sbjct: 244 P 244
Score = 36.2 bits (82), Expect = 0.18
Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 20/106 (18%)
Query: 806 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK-------ERDK 858
L++P E++ Q + + SK+ + EK ++ KK+ +KH+EK K
Sbjct: 34 LNRPRPTWEEVKEQLEKKKKGSKALAE---FEEKMNENWKKELEKHREKLLSGSESSSKK 90
Query: 859 EKKKEKEKKKSPK----------PKKKKHRKEKEERTKGKKKSKKQ 894
++K+KEKKKS + E E++ +GK++ KK+
Sbjct: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK 136
Score = 34.3 bits (77), Expect = 0.70
Identities = 37/162 (22%), Positives = 68/162 (41%), Gaps = 27/162 (16%)
Query: 808 KPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKER----------- 856
K LA+ E+ + ++ E K EK + E SKK ++K+K+ K+ R
Sbjct: 56 KALAEFEE-KMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDS 114
Query: 857 --------DKEKKKEK-EKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQ 907
D++KK+ K KKK + K E + K KK+ + E
Sbjct: 115 SSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDI 174
Query: 908 NGAPEEEQLPPES---SYSLLAENSYVKMTCDIRGSLQEDSQ 946
G ++ ++ E S L+E+ Y++ ++R ++ S+
Sbjct: 175 KGLSKKRKMYSEDKPLSSESLSESEYIE---EVRAKKKKSSE 213
Score = 33.9 bits (76), Expect = 0.92
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 13/127 (10%)
Query: 632 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 691
SDSE ED++ +++ R K S E E + +K+ K S +
Sbjct: 119 SDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK---------KKSKDGTE 169
Query: 692 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 751
+ +D G+ + + PL L S+ +EE R ++K +++ + K K+K
Sbjct: 170 KEKDIKGLSKKRKMYSE-DKPLSSESLSESEY---IEEVRAKKKKSSEEREKATEKTKKK 225
Query: 752 KGKRRHS 758
K ++HS
Sbjct: 226 KKHKKHS 232
Score = 30.8 bits (68), Expect = 7.8
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 5/86 (5%)
Query: 835 PMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK-----KHRKEKEERTKGKK 889
P E+ ++ +KK+K K +EK E KK+ K ++K + +K +R K +K
Sbjct: 39 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK 98
Query: 890 KSKKQPPGSEEAAGEPVQNGAPEEEQ 915
K + S ++ + + + E++
Sbjct: 99 KKSGRYSSSSSSSSDSSSSSSDSEDE 124
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 65.9 bits (159), Expect = 2e-10
Identities = 53/228 (23%), Positives = 97/228 (42%), Gaps = 26/228 (11%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEK-----------KGKRRHSSLPTESDEDIAPAQQVDI 776
E+ER ++ EK+K R K K+++K K + R E D D ++ D
Sbjct: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455
Query: 777 VTEEMPENALPSDE---DDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKD 833
E + + DE DK P R+ + + E+ ++ R+ +S+SP
Sbjct: 456 EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER---RRRRSRSSSRSPRTS 512
Query: 834 VPMVEKKSKKPKKKEKKHKEKERDKEK-----KKEKEK----KKSPKPKKKKHRKEKEER 884
+ K S+ P + + K+K+R+KE+ ++E+E+ +KS + K + EK
Sbjct: 513 KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST 572
Query: 885 TKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVK 932
+ +K+ K+P S + EE ++ + L EN K
Sbjct: 573 SLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 620
Score = 59.7 bits (143), Expect = 2e-08
Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 6/164 (3%)
Query: 730 ERRHRQKLEKDKRRKKRKEKEKKGKRRHS-SLPTESDEDIAPAQQVDIVTEEMPENALPS 788
++ R+ K+R K +E+ K R HS ++ E I ++V E
Sbjct: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 404
Query: 789 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 848
E +K+ R + D DK + +K R E K EKD ++K + +K+
Sbjct: 405 REKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 459
Query: 849 KKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSK 892
+K + KE D+++KK+K+ + P+ R R + +++S+
Sbjct: 460 EKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/175 (20%), Positives = 79/175 (45%), Gaps = 3/175 (1%)
Query: 731 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDE--DIAPAQQVDIVTEEMPENALPS 788
R + K R+KR + + + + + S + D +P ++ E +
Sbjct: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 372
Query: 789 DEDD-KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKK 847
D KD + + + +K + ++ + E K+ ++D + + K +K
Sbjct: 373 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432
Query: 848 EKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA 902
++ +EKE +K++ KEKEK++ + +++K R ++ + + K K + PP S A+
Sbjct: 433 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 487
Score = 50.4 bits (119), Expect = 9e-06
Identities = 26/103 (25%), Positives = 57/103 (55%), Gaps = 3/103 (2%)
Query: 819 QKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHR 878
+K R+ S+ KD +K K+ ++ ++K +EKER++EK++EKEK++ + K R
Sbjct: 365 RKSRSRSHSRDKRKDT---REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 421
Query: 879 KEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESS 921
++ E+ K K + +++ E+ + + +E++ + S
Sbjct: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 464
Score = 49.7 bits (117), Expect = 2e-05
Identities = 22/109 (20%), Positives = 60/109 (55%)
Query: 812 DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPK 871
D K +K + E K +++ +K ++ +K+ K+K++++++EK +EK+K+K +
Sbjct: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 434
Query: 872 PKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPES 920
+++K ++ ++ K K++ K++ + + + ++ + PP S
Sbjct: 435 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 483
Score = 47.8 bits (112), Expect = 6e-05
Identities = 27/100 (27%), Positives = 57/100 (57%), Gaps = 6/100 (6%)
Query: 819 QKHRNTETSKSPEKDVPMVEKKSKKPKKKEK---KHKEKERDKEKKKEKEKKKSPKPKKK 875
++ ++ E KS + ++K + K KEK K K++E+++E++KE+EK+K K
Sbjct: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416
Query: 876 KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+ ++ +++R K K+K +++ E E ++ E+EQ
Sbjct: 417 RDKEREKDREKDKEKDRER---EREKEHEKDRDKEKEKEQ 453
Score = 47.4 bits (111), Expect = 8e-05
Identities = 34/142 (23%), Positives = 75/142 (52%), Gaps = 10/142 (7%)
Query: 790 EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK 849
+D + P++ ++ + S K ++T K EK+ + EK +K +++EK
Sbjct: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKE-RVKEKDREKEREREK 403
Query: 850 -KHKEKER----DKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE---EA 901
+ KEKER D++K++EK+++K + +++ R+++ E+ + K+K K+Q E +
Sbjct: 404 EREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR 463
Query: 902 AGEPVQNGAPEEEQLPPESSYS 923
+ E + +++ P SY+
Sbjct: 464 SKEIDEKRKKDKKSRTPPRSYN 485
Score = 40.0 bits (92), Expect = 0.013
Identities = 17/79 (21%), Positives = 43/79 (54%), Gaps = 2/79 (2%)
Query: 839 KKSKKPKKKEKKHKEKERDKEKKKEKEKK--KSPKPKKKKHRKEKEERTKGKKKSKKQPP 896
K + K+ + KH+ + ++ + ++K+++ KSP K+ K R+ ++ R++ + K++
Sbjct: 321 KSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT 380
Query: 897 GSEEAAGEPVQNGAPEEEQ 915
+ E V+ E+E+
Sbjct: 381 REKIKEKERVKEKDREKER 399
Score = 34.3 bits (77), Expect = 0.70
Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 25/193 (12%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 692
D E + ER R HE++ R K + E D+E+ R + R +E K S +P +
Sbjct: 428 DKEKDREREREKEHEKD--RDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPPRS 483
Query: 693 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEER--RHRQKLEKDKRRKK----- 745
Y + + P + + +K + R R + +KDK+R+K
Sbjct: 484 Y-NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHI 542
Query: 746 --RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 803
R+E+E+ R SS + E + E +L E +K+P+
Sbjct: 543 SERRERERSTSMRKSSNDRDGKEKL-----------EKNSTSLKEKEHNKEPDSSVSKEV 591
Query: 804 IDLDKPLADSEKL 816
D D P + K+
Sbjct: 592 DDKDAPRTEENKI 604
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 65.9 bits (159), Expect = 2e-10
Identities = 53/228 (23%), Positives = 97/228 (42%), Gaps = 26/228 (11%)
Query: 728 EEERRHRQKLEKDKRRKKRKEKEK-----------KGKRRHSSLPTESDEDIAPAQQVDI 776
E+ER ++ EK+K R K K+++K K + R E D D ++ D
Sbjct: 280 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 339
Query: 777 VTEEMPENALPSDE---DDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKD 833
E + + DE DK P R+ + + E+ ++ R+ +S+SP
Sbjct: 340 EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER---RRRRSRSSSRSPRTS 396
Query: 834 VPMVEKKSKKPKKKEKKHKEKERDKEK-----KKEKEK----KKSPKPKKKKHRKEKEER 884
+ K S+ P + + K+K+R+KE+ ++E+E+ +KS + K + EK
Sbjct: 397 KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST 456
Query: 885 TKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVK 932
+ +K+ K+P S + EE ++ + L EN K
Sbjct: 457 SLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 504
Score = 59.7 bits (143), Expect = 2e-08
Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 6/164 (3%)
Query: 730 ERRHRQKLEKDKRRKKRKEKEKKGKRRHS-SLPTESDEDIAPAQQVDIVTEEMPENALPS 788
++ R+ K+R K +E+ K R HS ++ E I ++V E
Sbjct: 229 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 288
Query: 789 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 848
E +K+ R + D DK + +K R E K EKD ++K + +K+
Sbjct: 289 REKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 343
Query: 849 KKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSK 892
+K + KE D+++KK+K+ + P+ R R + +++S+
Sbjct: 344 EKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 387
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/175 (20%), Positives = 79/175 (45%), Gaps = 3/175 (1%)
Query: 731 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDE--DIAPAQQVDIVTEEMPENALPS 788
R + K R+KR + + + + + S + D +P ++ E +
Sbjct: 197 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 256
Query: 789 DEDD-KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKK 847
D KD + + + +K + ++ + E K+ ++D + + K +K
Sbjct: 257 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 316
Query: 848 EKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA 902
++ +EKE +K++ KEKEK++ + +++K R ++ + + K K + PP S A+
Sbjct: 317 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 371
Score = 50.4 bits (119), Expect = 9e-06
Identities = 26/103 (25%), Positives = 57/103 (55%), Gaps = 3/103 (2%)
Query: 819 QKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHR 878
+K R+ S+ KD +K K+ ++ ++K +EKER++EK++EKEK++ + K R
Sbjct: 249 RKSRSRSHSRDKRKDT---REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 305
Query: 879 KEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESS 921
++ E+ K K + +++ E+ + + +E++ + S
Sbjct: 306 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 348
Score = 49.7 bits (117), Expect = 2e-05
Identities = 22/109 (20%), Positives = 60/109 (55%)
Query: 812 DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPK 871
D K +K + E K +++ +K ++ +K+ K+K++++++EK +EK+K+K +
Sbjct: 259 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 318
Query: 872 PKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPES 920
+++K ++ ++ K K++ K++ + + + ++ + PP S
Sbjct: 319 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 367
Score = 47.8 bits (112), Expect = 6e-05
Identities = 27/100 (27%), Positives = 57/100 (57%), Gaps = 6/100 (6%)
Query: 819 QKHRNTETSKSPEKDVPMVEKKSKKPKKKEK---KHKEKERDKEKKKEKEKKKSPKPKKK 875
++ ++ E KS + ++K + K KEK K K++E+++E++KE+EK+K K
Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 300
Query: 876 KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+ ++ +++R K K+K +++ E E ++ E+EQ
Sbjct: 301 RDKEREKDREKDKEKDRER---EREKEHEKDRDKEKEKEQ 337
Score = 47.4 bits (111), Expect = 8e-05
Identities = 34/142 (23%), Positives = 75/142 (52%), Gaps = 10/142 (7%)
Query: 790 EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK 849
+D + P++ ++ + S K ++T K EK+ + EK +K +++EK
Sbjct: 230 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKE-RVKEKDREKEREREK 287
Query: 850 -KHKEKER----DKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE---EA 901
+ KEKER D++K++EK+++K + +++ R+++ E+ + K+K K+Q E +
Sbjct: 288 EREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR 347
Query: 902 AGEPVQNGAPEEEQLPPESSYS 923
+ E + +++ P SY+
Sbjct: 348 SKEIDEKRKKDKKSRTPPRSYN 369
Score = 40.0 bits (92), Expect = 0.013
Identities = 17/79 (21%), Positives = 43/79 (54%), Gaps = 2/79 (2%)
Query: 839 KKSKKPKKKEKKHKEKERDKEKKKEKEKK--KSPKPKKKKHRKEKEERTKGKKKSKKQPP 896
K + K+ + KH+ + ++ + ++K+++ KSP K+ K R+ ++ R++ + K++
Sbjct: 205 KSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT 264
Query: 897 GSEEAAGEPVQNGAPEEEQ 915
+ E V+ E+E+
Sbjct: 265 REKIKEKERVKEKDREKER 283
Score = 34.3 bits (77), Expect = 0.70
Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 25/193 (12%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 692
D E + ER R HE++ R K + E D+E+ R + R +E K S +P +
Sbjct: 312 DKEKDREREREKEHEKD--RDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPPRS 367
Query: 693 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEER--RHRQKLEKDKRRKK----- 745
Y + + P + + +K + R R + +KDK+R+K
Sbjct: 368 Y-NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHI 426
Query: 746 --RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 803
R+E+E+ R SS + E + E +L E +K+P+
Sbjct: 427 SERRERERSTSMRKSSNDRDGKEKL-----------EKNSTSLKEKEHNKEPDSSVSKEV 475
Query: 804 IDLDKPLADSEKL 816
D D P + K+
Sbjct: 476 DDKDAPRTEENKI 488
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 65.5 bits (158), Expect = 3e-10
Identities = 36/117 (30%), Positives = 67/117 (57%), Gaps = 7/117 (5%)
Query: 778 TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMV 837
TEE E +E++K+ + + EK +K + TE K E++
Sbjct: 10 TEETEETEETEEEEEKEGKRKEKRKE-------KRKEKEKKKKTKETEKRKEKEEEEKKR 62
Query: 838 EKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
++K KK K++E++ +E+E ++E+K+E+EK++ + KKKK R+ KEE + KKK +++
Sbjct: 63 KRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
Score = 64.7 bits (156), Expect = 5e-10
Identities = 32/88 (36%), Positives = 52/88 (59%)
Query: 828 KSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKG 887
K +K+ E+ + +++EK+ K KE+ KEK+KEKEKKK K +K+ KE+EE+ +
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRK 63
Query: 888 KKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+K+ KK+ E E + EEE+
Sbjct: 64 RKRKKKKEEEEREEEEEEEEEEKEEEEK 91
Score = 62.8 bits (151), Expect = 2e-09
Identities = 30/76 (39%), Positives = 49/76 (64%)
Query: 825 ETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEER 884
ET + EK+ EK+ +K K+KEKK K KE +K K+KE+E+KK + +KKK +E+ E
Sbjct: 18 ETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREE 77
Query: 885 TKGKKKSKKQPPGSEE 900
+ +++ +K+ EE
Sbjct: 78 EEEEEEEEKEEEEKEE 93
Score = 57.0 bits (136), Expect = 1e-07
Identities = 29/108 (26%), Positives = 59/108 (54%)
Query: 808 KPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKK 867
K ++E+ + E K ++ EK+ +K KKK+ K EK ++KE++++K K+
Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64
Query: 868 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
K K K+++ R+E+EE + +K+ +++ G + + EEE+
Sbjct: 65 KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEK 112
Score = 55.1 bits (131), Expect = 4e-07
Identities = 29/78 (37%), Positives = 47/78 (60%)
Query: 842 KKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 901
KK KKK+K+ +E E +E ++E+EK+ K K+K+ RKEKE++ K K+ K++ EE
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 902 AGEPVQNGAPEEEQLPPE 919
+ + EEE+ E
Sbjct: 61 KRKRKRKKKKEEEEREEE 78
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/89 (35%), Positives = 48/89 (53%), Gaps = 12/89 (13%)
Query: 839 KKSKKPKKK--------EKKHKEKERDKEKKKEKEKKKSPKPKKK----KHRKEKEERTK 886
KK KK KK+ E + +E++ K K+K KEK+K + KKK + RKEKEE K
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 887 GKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 915
+K+ +K+ EE E + +EE+
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEE 89
Score = 51.2 bits (121), Expect = 6e-06
Identities = 34/143 (23%), Positives = 59/143 (41%), Gaps = 39/143 (27%)
Query: 729 EERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPS 788
EE ++ K+KR++KRKEKEKK K + + E +E+
Sbjct: 20 EEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEE--------------------- 58
Query: 789 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 848
+K K ++ E + E++ EK+ + +KK+
Sbjct: 59 ------------------EKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100
Query: 849 KKHKEKERDKEKKKEKEKKKSPK 871
KK + KE ++EKKK++ +K K
Sbjct: 101 KKRRRKEEEEEKKKKRRRKTKKK 123
Score = 38.1 bits (87), Expect = 0.049
Identities = 24/113 (21%), Positives = 56/113 (49%)
Query: 647 EEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQ 706
+E + + +E +EE+ +R+E RK+++ K+ + +++ ++ + +
Sbjct: 8 KETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRK 67
Query: 707 IDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSS 759
+ ++ + EE+ R++ +K KRR+K +E+EKK KRR +
Sbjct: 68 KKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKT 120
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 64.3 bits (155), Expect = 6e-10
Identities = 41/187 (21%), Positives = 91/187 (48%), Gaps = 9/187 (4%)
Query: 722 DQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM 781
D + KLEEE+ ++K E+ + K+R+E+E++ +R E + + ++ + E
Sbjct: 286 DTHKKLEEEKGKKEK-ERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 782 PENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 841
E D + D R D D D+ + + R + E++ ++
Sbjct: 345 RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE 404
Query: 842 KKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 901
++ +++ ++ +E+ER++E+++EK+KK+ R+E EE ++K +++ E A
Sbjct: 405 REREREREREREREREREREREKDKKRD--------REEDEEDAYERRKLERKLREKEAA 456
Query: 902 AGEPVQN 908
E ++N
Sbjct: 457 YQERLKN 463
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/291 (18%), Positives = 114/291 (39%), Gaps = 25/291 (8%)
Query: 633 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 692
+ E E ER R E E+ R + R E + E + + R +E+ Y + + R
Sbjct: 392 EREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLR 451
Query: 693 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRK--KRKEKE 750
++ E + +I ER+ ++ EK+ R+ +R+E
Sbjct: 452 EKEAAYQERLKNWEI---------------------RERKKTREYEKEAEREEERRREMA 490
Query: 751 KKGKRRHSSLPT-ESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKP 809
K+ KR L + D D + + + + + + D++D L+ +
Sbjct: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
Query: 810 LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKS 869
LA+ P + + E + + ++ + +++EK+ KE++R++ ++E+E ++
Sbjct: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Query: 870 PKPKKK-KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPE 919
P K + + + PG E G + + ++Q P E
Sbjct: 611 PCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEE 661
Score = 51.2 bits (121), Expect = 6e-06
Identities = 42/157 (26%), Positives = 79/157 (50%), Gaps = 38/157 (24%)
Query: 743 RKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRAL 802
RKK+KEK++ RR +AP ++T+E NA+ +ED +D
Sbjct: 234 RKKKKEKKEDIFRRFP---------VAPLIPYPLITKE-DINAIEMEEDKRD-------- 275
Query: 803 DIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKK 862
L E I K R+T EK KK K+ ++ EK+ +E+ER++E+++
Sbjct: 276 -------LISRE---ISKFRDTHKKLEEEKG-----KKEKERQEIEKERRERERERERER 320
Query: 863 EK-----EKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
E+ E+++ + +K+K R+ + ER + + ++K++
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKER 357
Score = 50.8 bits (120), Expect = 7e-06
Identities = 53/313 (16%), Positives = 132/313 (42%), Gaps = 17/313 (5%)
Query: 603 ELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADE 662
++N + + K+ + + ++ L + + + E+ R +E + R + R E +
Sbjct: 263 DINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER 322
Query: 663 EELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSD 722
E R RE ++ + K ++R +D + + D + +
Sbjct: 323 REREREREREREREKE-----KERERERERDRDRDRTK-----ERDRDRDRERDRDRDRE 372
Query: 723 QYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMP 782
+ ++R ++ +D+ R++ +E+E++ +R E + + ++ + E
Sbjct: 373 RSSDRNKDRSRSREKSRDRERERERERERERERER-----EREREREREREREREREREK 427
Query: 783 ENALPSDEDDKDPNDPYRALDIDL-DKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 841
+ +ED++D + R L+ L +K A E+L + R + ++ EK+ E++
Sbjct: 428 DKKRDREEDEEDAYER-RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486
Query: 842 KKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 901
++ K+ K+ KE D + ++ K +K+ R ++E ++ K++ EE
Sbjct: 487 REMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEI 546
Query: 902 AGEPVQNGAPEEE 914
+ G P+ +
Sbjct: 547 RQRLLAEGHPDPD 559
Score = 42.7 bits (99), Expect = 0.002
Identities = 34/169 (20%), Positives = 77/169 (45%), Gaps = 15/169 (8%)
Query: 745 KRKEKEKKGKRRHSSLPTESDED-----------IAPAQQVDIVTEEMPENALPSDEDDK 793
K K+K G R ++ + +E I A +V ++ E E PS E D
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV-LIREYSSELNAPSQESDS 231
Query: 794 DPNDPYRALDIDLDK--PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKH 851
P + D+ + P+A P+ + + E ++ ++ K + KK
Sbjct: 232 HPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKL 291
Query: 852 KEKERDKEKKKEK-EKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 899
+E++ KEK++++ EK++ + ++++ +E+ ER + +++ +++ E
Sbjct: 292 EEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKE 340
Score = 42.4 bits (98), Expect = 0.003
Identities = 58/285 (20%), Positives = 106/285 (37%), Gaps = 28/285 (9%)
Query: 627 INEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSS 686
+ E L D + + + P+ Q+R + R E + +E R+RE + E+ +
Sbjct: 496 LKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH 555
Query: 687 PSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKR 746
P P Q + + P Q + EEE +Q EK+++R++
Sbjct: 556 PDPDAELQ-------------RMEQEAERRRQPQIKQEPESEEEEEEKQ--EKEEKREEP 600
Query: 747 KEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDL 806
E+E++ +++ PT AP+ NA P+ D+ P +
Sbjct: 601 MEEEEEPEQKPCLKPTLRPISSAPS------VSSASGNATPNTPGDESPCGIIIPHENSP 654
Query: 807 DKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE-KKHKEKERDKEKKKEK- 864
D+ + + I S SP + P K+ K P K ++++ D +K K
Sbjct: 655 DQQQPEEHRPKIGLSLKLGASNSPGQ--PNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKL 712
Query: 865 ---EKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 906
+ + K K +E+R K +K P E P+
Sbjct: 713 VPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPL 757
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,312,099
Number of Sequences: 37866
Number of extensions: 2247422
Number of successful extensions: 59543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 725
Number of HSP's successfully gapped in prelim test: 1050
Number of HSP's that attempted gapping in prelim test: 19632
Number of HSP's gapped (non-prelim): 16185
length of query: 1153
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1040
effective length of database: 13,968,660
effective search space: 14527406400
effective search space used: 14527406400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.