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Search of human proteins with 10835091
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 932 0.0
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 565 e-161
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 520 e-147
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 402 e-112
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 398 e-111
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 177 1e-44
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 177 1e-44
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 177 1e-44
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 176 4e-44
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 149 4e-36
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 142 6e-34
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 140 2e-33
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 133 4e-31
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 126 5e-29
gi|7705308 growth differentiation factor 2 [Homo sapiens] 125 6e-29
gi|110349792 growth differentiation factor 1 [Homo sapiens] 118 1e-26
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 117 2e-26
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 108 8e-24
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 104 1e-22
gi|4504699 inhibin beta A precursor [Homo sapiens] 102 5e-22
gi|222352098 nodal precursor [Homo sapiens] 100 3e-21
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 94 3e-19
gi|4885259 myostatin [Homo sapiens] 93 6e-19
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 87 2e-17
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 87 2e-17
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 86 9e-17
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 85 1e-16
gi|13899338 activin beta E [Homo sapiens] 85 2e-16
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 84 3e-16
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 80 5e-15
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 932 bits (2409), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG 60
MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
Sbjct: 1 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG 60
Query: 61 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP 120
LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
Sbjct: 61 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP 120
Query: 121 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF 180
NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
Sbjct: 121 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF 180
Query: 181 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA 240
RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
Sbjct: 181 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA 240
Query: 241 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF 300
QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
Sbjct: 241 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF 300
Query: 301 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV 360
MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
Sbjct: 301 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV 360
Query: 361 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA 420
SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
Sbjct: 361 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA 420
Query: 421 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
Sbjct: 421 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 565 bits (1457), Expect = e-161
Identities = 281/426 (65%), Positives = 339/426 (79%), Gaps = 30/426 (7%)
Query: 31 DNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTN 90
DN VHSSFI+RRLR+ ERRE+QREILSILGLPHRPRP GK +SAP+FMLDLYNAM
Sbjct: 34 DNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKH-NSAPMFMLDLYNAMAV 92
Query: 91 EENPEESEYSVRASLAEETRGARKGYPASPN-GYPRRIQLSRTTPLTTQSPPLASLHDTN 149
EE G P YP + S TQ PPLASL D++
Sbjct: 93 EEG---------------------GGPGGQGFSYPYKAVFS------TQGPPLASLQDSH 125
Query: 150 FLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRF 209
FL DADMVMSFVNLVE DK+F H R H++EFRFDL++IP GEAVTAAEFRIYKD RF
Sbjct: 126 FLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERF 185
Query: 210 ENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGL 269
+NET +IS+YQ+++E+ R++DLFLLD+R A + GWLVFDIT TSNHWV+NP++NLGL
Sbjct: 186 DNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGL 245
Query: 270 QLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRA-ANKRKNQNRNK 328
QL ET DG+SIN K AGL+GR GPQ+KQPFMVAFFKA+EV RS+R+ +K+++QNR+K
Sbjct: 246 QLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSK 305
Query: 329 SSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSF 388
+ +Q++ RM++V + ++S+Q+QACKKHELYVSFRDLGWQDWIIAPEGYAA+YC+GEC+F
Sbjct: 306 TPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAF 365
Query: 389 PLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVV 448
PLN++MNATNHAIVQTLVH + P+ VPKPCCAPT+LNAISVLYFDDSSNVILKKYRNMVV
Sbjct: 366 PLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVV 425
Query: 449 RSCGCH 454
R+CGCH
Sbjct: 426 RACGCH 431
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 520 bits (1338), Expect = e-147
Identities = 268/454 (59%), Positives = 330/454 (72%), Gaps = 39/454 (8%)
Query: 36 SSFIYRRLRNHERREIQREILSILGLPHRPRPFS-------------------------- 69
S F+YRRL+ E+RE+Q+EILS+LGLPHRPRP
Sbjct: 64 SGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGE 123
Query: 70 -PGKQASSAPLFMLDLYNAMT--NEENPEESEYSVRASLAEETRGARKGYPASPNGYPRR 126
P + SAPLFMLDLYNA++ N+E+ ++ E +++ P +P
Sbjct: 124 PPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHP-- 181
Query: 127 IQLSRTTPLTTQS-----PPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFR 181
L+R + L S PL S D+ FLNDADMVMSFVNLVE DK+FS ++RH+KEF+
Sbjct: 182 --LNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFK 239
Query: 182 FDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQ 241
F+L+QIP GE VTAAEFRIYKD F+N+T ISIYQ+++E+ +RD+DLFLLDTR
Sbjct: 240 FNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVW 299
Query: 242 ALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFM 301
A + GWL FDIT TSN WV+ PQ+N+GLQL T DG ++ ++AGLVGR GP KQPFM
Sbjct: 300 ASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFM 359
Query: 302 VAFFKASEVLLRSVRAAN-KRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV 360
VAFFK SEV +R+ R+A+ +R+ Q+RN+S+ QD +R+SS DYN+SE K AC+KHELYV
Sbjct: 360 VAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYV 419
Query: 361 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA 420
SF+DLGWQDWIIAP+GYAA YCDGECSFPLNAHMNATNHAIVQTLVHLM P++VPKPCCA
Sbjct: 420 SFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCA 479
Query: 421 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
PTKLNAISVLYFDD+SNVILKKYRNMVVR+CGCH
Sbjct: 480 PTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 402 bits (1032), Expect = e-112
Identities = 206/418 (49%), Positives = 281/418 (67%), Gaps = 53/418 (12%)
Query: 41 RRLRNHERREIQREILSILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEES 97
RRL ERR++QREIL++LGLP RPRP +P + +SAPLFMLDLY+AM +++ +
Sbjct: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED-- 91
Query: 98 EYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMV 157
G P +L R AD+V
Sbjct: 92 ------------------------GAPAERRLGR----------------------ADLV 105
Query: 158 MSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKIS 217
MSFVN+VERD+ HQ H+KEFRFDLTQIP GEAVTAAEFRIYK S + N T+ +S
Sbjct: 106 MSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVS 164
Query: 218 IYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGD 277
++Q+++E +NR++DLF LD + +A D GWLV D+T S+ W++ +LGL+L ET D
Sbjct: 165 MFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETED 224
Query: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSR 337
G S++ AGL+G++ P+S+QPF+V FF+AS +R+ RA + + KS+ ++R
Sbjct: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANR 284
Query: 338 MSSV-GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNA 396
+ + D + S +Q C++HELYVSF+DLGW DW+IAP+GY+A+YC+GECSFPL++ MNA
Sbjct: 285 LPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNA 344
Query: 397 TNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
TNHAI+Q+LVHLM PD VPK CCAPTKL+A SVLY+D S+NVIL+K+RNMVV++CGCH
Sbjct: 345 TNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 398 bits (1023), Expect = e-111
Identities = 205/418 (49%), Positives = 280/418 (66%), Gaps = 53/418 (12%)
Query: 41 RRLRNHERREIQREILSILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEES 97
RRL ERR++QREIL++LGLP RPRP +P + +SAPLFMLDLY+AM +++ +
Sbjct: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED-- 91
Query: 98 EYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMV 157
G P +L R AD+V
Sbjct: 92 ------------------------GAPAEQRLGR----------------------ADLV 105
Query: 158 MSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKIS 217
MSFVN+VERD+ HQ H+KEFRFDLTQIP GEAVTAAEFRIYK S + N T+ +S
Sbjct: 106 MSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVS 164
Query: 218 IYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGD 277
++Q+++E +NR++DLF LD + +A D GWLV D+T S+ W++ +LGL+L ET D
Sbjct: 165 MFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETED 224
Query: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSR 337
G S++ AGL+G++ P+S+QPF+V FF+AS +R+ RA + + KS+ ++R
Sbjct: 225 GHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANR 284
Query: 338 MSSV-GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNA 396
+ + D S +Q C++HELYVSF+DLGW DW+IAP+GY+A+YC+GECSFPL++ MNA
Sbjct: 285 LPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNA 344
Query: 397 TNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 454
TNHAI+Q+LVHLM P+ VPK CCAPTKL+A SVLY+D S+NVIL+K+RNMVV++CGCH
Sbjct: 345 TNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 177 bits (450), Expect = 1e-44
Identities = 123/422 (29%), Positives = 197/422 (46%), Gaps = 75/422 (17%)
Query: 44 RNHER-REIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVR 102
++HE R+ + +L + GL RP+P +++ P +M DLY + EE E+ +
Sbjct: 49 QSHELLRDFEATLLQMFGLRRRPQP----SKSAVIPDYMRDLYRLQSGEEEEEQ----IH 100
Query: 103 ASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVN 162
++ E YP P +++ + S H L N
Sbjct: 101 STGLE--------YPERP---------------ASRANTVRSFHHEEHLE---------N 128
Query: 163 LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNR--FENETIKISIYQ 220
+ ++ + + F F+L+ IP E +++AE R+++++ + +E +I+IY+
Sbjct: 129 IPGTSENSAFR------FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 221 IIK---EYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQL------ 271
++K E LLDTR W FD++ W Q N GL +
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLH 242
Query: 272 CAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331
T G+ + + + G +P +V F A R+ + +
Sbjct: 243 QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGR------GHALTRRRRAKRSPKH 296
Query: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLN 391
H +R ++ + C++H LYV F D+GW DWI+AP GY AFYC G+C FPL
Sbjct: 297 HSQRAR----------KKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA 346
Query: 392 AHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSC 451
H+N+TNHAIVQTLV+ + +PK CC PT+L+AIS+LY D+ V+LK Y+ MVV C
Sbjct: 347 DHLNSTNHAIVQTLVNSV-NSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC 405
Query: 452 GC 453
GC
Sbjct: 406 GC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 177 bits (450), Expect = 1e-44
Identities = 123/422 (29%), Positives = 197/422 (46%), Gaps = 75/422 (17%)
Query: 44 RNHER-REIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVR 102
++HE R+ + +L + GL RP+P +++ P +M DLY + EE E+ +
Sbjct: 49 QSHELLRDFEATLLQMFGLRRRPQP----SKSAVIPDYMRDLYRLQSGEEEEEQ----IH 100
Query: 103 ASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVN 162
++ E YP P +++ + S H L N
Sbjct: 101 STGLE--------YPERP---------------ASRANTVRSFHHEEHLE---------N 128
Query: 163 LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNR--FENETIKISIYQ 220
+ ++ + + F F+L+ IP E +++AE R+++++ + +E +I+IY+
Sbjct: 129 IPGTSENSAFR------FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 221 IIK---EYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQL------ 271
++K E LLDTR W FD++ W Q N GL +
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLH 242
Query: 272 CAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331
T G+ + + + G +P +V F A R+ + +
Sbjct: 243 QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGR------GHALTRRRRAKRSPKH 296
Query: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLN 391
H +R ++ + C++H LYV F D+GW DWI+AP GY AFYC G+C FPL
Sbjct: 297 HSQRAR----------KKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA 346
Query: 392 AHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSC 451
H+N+TNHAIVQTLV+ + +PK CC PT+L+AIS+LY D+ V+LK Y+ MVV C
Sbjct: 347 DHLNSTNHAIVQTLVNSV-NSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC 405
Query: 452 GC 453
GC
Sbjct: 406 GC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 177 bits (450), Expect = 1e-44
Identities = 123/422 (29%), Positives = 197/422 (46%), Gaps = 75/422 (17%)
Query: 44 RNHER-REIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVR 102
++HE R+ + +L + GL RP+P +++ P +M DLY + EE E+ +
Sbjct: 49 QSHELLRDFEATLLQMFGLRRRPQP----SKSAVIPDYMRDLYRLQSGEEEEEQ----IH 100
Query: 103 ASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVN 162
++ E YP P +++ + S H L N
Sbjct: 101 STGLE--------YPERP---------------ASRANTVRSFHHEEHLE---------N 128
Query: 163 LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNR--FENETIKISIYQ 220
+ ++ + + F F+L+ IP E +++AE R+++++ + +E +I+IY+
Sbjct: 129 IPGTSENSAFR------FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYE 182
Query: 221 IIK---EYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQL------ 271
++K E LLDTR W FD++ W Q N GL +
Sbjct: 183 VMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLH 242
Query: 272 CAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331
T G+ + + + G +P +V F A R+ + +
Sbjct: 243 QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGR------GHALTRRRRAKRSPKH 296
Query: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLN 391
H +R ++ + C++H LYV F D+GW DWI+AP GY AFYC G+C FPL
Sbjct: 297 HSQRAR----------KKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA 346
Query: 392 AHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSC 451
H+N+TNHAIVQTLV+ + +PK CC PT+L+AIS+LY D+ V+LK Y+ MVV C
Sbjct: 347 DHLNSTNHAIVQTLVNSV-NSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC 405
Query: 452 GC 453
GC
Sbjct: 406 GC 407
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 176 bits (446), Expect = 4e-44
Identities = 123/409 (30%), Positives = 180/409 (44%), Gaps = 70/409 (17%)
Query: 50 EIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEET 109
E + +LS+ GL RP P + + P +MLDLY + +
Sbjct: 52 EFELRLLSMFGLKQRPTP----SRDAVVPPYMLDLYRRHSGQP----------------- 90
Query: 110 RGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKD 169
G PA + R + T L L +T+
Sbjct: 91 -----GSPAPDHRLERAASRANTVRSFHHEESLEELPETS-------------------- 125
Query: 170 FSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI---KISIYQIIKEYT 226
+ + F F+L+ IP E +T+AE ++++++ + N + +I+IY+IIK T
Sbjct: 126 ----GKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPAT 181
Query: 227 --NRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVK 284
++ LLDTR W FD+T W N G V+
Sbjct: 182 ANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFV------------VE 229
Query: 285 SAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDY 344
A L +QG + + E +R + H+ R +
Sbjct: 230 VAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAK--HK 287
Query: 345 NTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404
K +CK+H LYV F D+GW DWI+AP GY AFYC GEC FPL H+N+TNHAIVQT
Sbjct: 288 QRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQT 347
Query: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
LV+ + +PK CC PT+L+AIS+LY D++ V+LK Y++MVV CGC
Sbjct: 348 LVNSV-NSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 149 bits (377), Expect = 4e-36
Identities = 81/230 (35%), Positives = 124/230 (53%), Gaps = 16/230 (6%)
Query: 234 LLDTRKAQALD-VGWLVFDITVTSNHWVINPQNNLGLQLCAETGD---GRSINVKSAGL- 288
LLD R LD GW VFDI W + QLC E GR+++++ G
Sbjct: 277 LLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFD 330
Query: 289 -VGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV----GD 343
RQ + + K ++ ++A + + ++ + Q R + + G
Sbjct: 331 RAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGK 390
Query: 344 YNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQ 403
+ K C + L+V+F+D+GW DWIIAP Y AF+C+G C FPL +H+ TNHA++Q
Sbjct: 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQ 450
Query: 404 TLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
TL++ M P+ P CC PT+L+ IS+L+ D ++NV+ K+Y +MVV SCGC
Sbjct: 451 TLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 142 bits (358), Expect = 6e-34
Identities = 99/352 (28%), Positives = 156/352 (44%), Gaps = 56/352 (15%)
Query: 147 DTNFLNDADMVMSFVNLVERD-KDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRS 205
+ +F + + + V+R D SH +++ FD++ + E + AE R+++
Sbjct: 114 NASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAP 173
Query: 206 NNRFENET--IKISIYQIIKEYTNRDADLFLLDTRKAQ---ALDVGWLVFDITVTSNHWV 260
+ + + + ++ + LLD R A GW VFD+ H
Sbjct: 174 SAPWGPPAGPLHVQLFPCLSP--------LLLDARTLDPQGAPPAGWEVFDVWQGLRH-- 223
Query: 261 INPQNNLGLQLCAETGD---GRSI------------NVKSAGLVGRQGPQSKQPFMVAF- 304
P L L+L A G+ G + +++S G R P ++ +V F
Sbjct: 224 -QPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFT 282
Query: 305 -------FKASEVLLRSVRAANKRKNQNRN----------------KSSSHQDSSRMSSV 341
F L S AA + + ++ S
Sbjct: 283 RSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRH 342
Query: 342 GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAI 401
G + + + C K L+V+F++LGW DWIIAP Y A++C+G C FPL +H+ TNHAI
Sbjct: 343 GKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAI 402
Query: 402 VQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
+QTL++ M P P CC PTKL IS+LY D +NV+ K+Y +MVV SCGC
Sbjct: 403 IQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 140 bits (353), Expect = 2e-33
Identities = 91/340 (26%), Positives = 154/340 (45%), Gaps = 44/340 (12%)
Query: 147 DTNFLNDADMVMSFVN--LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYK-- 202
D + A+++ SF N L + F+ R++ F IPH E V AE R+Y
Sbjct: 95 DRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFN---VSIPHHEEVIMAELRLYTLV 151
Query: 203 DRSNNRFENETIKISIYQIIKEYTNRDAD--LFLLDTRKAQALDVGWLVFDITVTSNHWV 260
R ++ KI+I+++++ + + + + +L + + + W FD+T W
Sbjct: 152 QRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQ 211
Query: 261 INPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAFFKASEVLLRSVRAAN 319
+ + L++ E+ + + S L Q+K P ++ F ++++
Sbjct: 212 KSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVF--------SDDQSSD 263
Query: 320 KRKNQNRNKSSSHQDSSRMSSVG--DYNTSEQKQA------------------------C 353
K + + N+ SH+ + ++G +++ ++A C
Sbjct: 264 KERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYC 323
Query: 354 KKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDH 413
K+ LY+ F+++GW WIIAP GY A+ C G C++PL H+ T HAI+Q LVHL
Sbjct: 324 KRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQK 383
Query: 414 VPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
K CC PTKL IS+LY D KY M V CGC
Sbjct: 384 ASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 133 bits (334), Expect = 4e-31
Identities = 53/104 (50%), Positives = 75/104 (72%)
Query: 350 KQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLM 409
+ C + L+V F++LGW DWIIAP Y A++C+G C FPL +H+ TNHAI+QTL++ M
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405
Query: 410 FPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
PD P CC P +L+ IS+LY D ++NV+ K+Y +MVV +CGC
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 126 bits (316), Expect = 5e-29
Identities = 83/279 (29%), Positives = 140/279 (50%), Gaps = 33/279 (11%)
Query: 182 FDLTQIPHGEAVTAAEFRIYKDRSNNRFEN--ETIKISIYQIIKEY-----TNRDADLFL 234
F+L+ I E +T A+ + D N + N ++++++ + + + T + +F+
Sbjct: 111 FNLSAIKEREQLTLAQLGL--DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFV 168
Query: 235 LDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGP 294
L ++ G + F++ + W NP+ N GL L + R V P
Sbjct: 169 L---RSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQ-------P 218
Query: 295 QSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACK 354
+ + AS +++ N H R +++ S K C
Sbjct: 219 EDTCARLRCSLHASLLVV------------TLNPDQCHPSRKRRAAIPVPKLS-CKNLCH 265
Query: 355 KHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHV 414
+H+L+++FRDLGW WIIAP+G+ A YC GEC F L +N++N+A +Q L+H + P+ +
Sbjct: 266 RHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPE-I 324
Query: 415 PKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
P+ C PTKL+ IS+LY D++ NVIL+ Y +MVV CGC
Sbjct: 325 PQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 125 bits (315), Expect = 6e-29
Identities = 93/294 (31%), Positives = 130/294 (44%), Gaps = 31/294 (10%)
Query: 187 IPHGEAVTAAEFRIYKDRSNNRFENETIK--ISIYQIIKEYTNRDADLFLLDTRKAQAL- 243
IP E +T AE R+Y N+ + +K + IY ++ D+ +Q +
Sbjct: 139 IPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQ 198
Query: 244 DVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ--PFM 301
D GW +++ WV + +L R K + P + PF
Sbjct: 199 DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHR----KGCDTLDISVPPGSRNLPFF 254
Query: 302 VAFF-------KASEVLLRSV---------RAANKRKNQNRNKSSSHQDSSRMSSVGDYN 345
V F K + + LR + + +K + +SS +D+ + G
Sbjct: 255 VVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTL 314
Query: 346 TSEQKQA-----CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHA 400
++ A C+K L V+F D+GW WIIAP+ Y A+ C G C FPL + T HA
Sbjct: 315 ARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHA 374
Query: 401 IVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILK-KYRNMVVRSCGC 453
IVQTLVHL FP V K CC PTKL+ ISVLY DD LK Y M V CGC
Sbjct: 375 IVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 118 bits (295), Expect = 1e-26
Identities = 50/106 (47%), Positives = 71/106 (66%), Gaps = 4/106 (3%)
Query: 352 ACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPL----NAHMNATNHAIVQTLVH 407
AC+ LYVSFR++GW W+IAP G+ A YC G+C+ P+ + A NHA+++ L+H
Sbjct: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
Query: 408 LMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
P PCC P +L+ ISVL+FD+S NV+L++Y +MVV CGC
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 117 bits (294), Expect = 2e-26
Identities = 52/145 (35%), Positives = 85/145 (58%), Gaps = 7/145 (4%)
Query: 316 RAANKRKNQNRNKSSSHQDSSRMS-SVGDYNTSEQKQ-----ACKKHELYVSFRDLGWQD 369
+A K KN+ + + H+ S + + +KQ C + L V F D+GW +
Sbjct: 327 QAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSE 386
Query: 370 WIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLM-FPDHVPKPCCAPTKLNAIS 428
WII+P+ + A+YC G C FP+ + +NHA +Q++V + +P+PCC P K++++S
Sbjct: 387 WIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS 446
Query: 429 VLYFDDSSNVILKKYRNMVVRSCGC 453
+L+FD++ NV+LK Y NM V SC C
Sbjct: 447 ILFFDENKNVVLKVYPNMTVESCAC 471
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 108 bits (271), Expect = 8e-24
Identities = 43/107 (40%), Positives = 70/107 (65%), Gaps = 1/107 (0%)
Query: 348 EQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVH 407
++ + C + L V F D+GW +WII+P+ + A+YC G C FP+ + +NHA +Q++V
Sbjct: 371 DEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVR 430
Query: 408 LM-FPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
+ +P+PCC P K+N++ VL+ D++ NV+LK Y NM V +C C
Sbjct: 431 AVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 104 bits (260), Expect = 1e-22
Identities = 66/229 (28%), Positives = 104/229 (45%), Gaps = 18/229 (7%)
Query: 236 DTRKAQALDVGWLVFDIT--VTSNHWVINPQNNLGLQ-LCAETGDGRSINVKSAGLVGRQ 292
D+ K + W DIT V W L L+ +C + D S GL
Sbjct: 170 DSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKD-------SGGLELWH 222
Query: 293 GPQSKQ-PFMVAFF-------KASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDY 344
G S F++ +F + ++ L R + +R++ R + S+ +++
Sbjct: 223 GTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSK 282
Query: 345 NTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404
++ + C H +SFR LGW WIIAP Y YC G C L +N+ NHAI+Q
Sbjct: 283 HSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342
Query: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
L++ + VP+P C P K ISVL + + +++ K+Y M+ SC C
Sbjct: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 102 bits (255), Expect = 5e-22
Identities = 46/105 (43%), Positives = 61/105 (58%), Gaps = 4/105 (3%)
Query: 353 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD 412
C K + +VSF+D+GW DWIIAP GY A YC+GEC + ++ + H
Sbjct: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380
Query: 413 HVP----KPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
H P K CC PTKL +S+LY+DD N+I K +NM+V CGC
Sbjct: 381 HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 100 bits (249), Expect = 3e-21
Identities = 43/110 (39%), Positives = 66/110 (60%), Gaps = 1/110 (0%)
Query: 344 YNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQ 403
++ ++ Q C+K + V F +GW WII P+ Y A+ C+GEC P+ + TNHA +Q
Sbjct: 238 HHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQ 297
Query: 404 TLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
+L+ P VP CCAP K +S+LY D+ V+L +++M+V CGC
Sbjct: 298 SLLKRYQPHRVPSTCCAPVKTKPLSMLYV-DNGRVLLDHHKDMIVEECGC 346
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 93.6 bits (231), Expect = 3e-19
Identities = 64/207 (30%), Positives = 88/207 (42%), Gaps = 35/207 (16%)
Query: 247 WLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFK 306
W D + W PQ+N G+++ A G + V S G G + PFM
Sbjct: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285
Query: 307 ASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLG 366
+R K RN + D ++SE + C ++ L V F G
Sbjct: 286 -------ELRVLENTKRSRRN----------LGLDCDEHSSESR--CCRYPLTVDFEAFG 326
Query: 367 WQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNA 426
W DWIIAP+ Y A YC G+C + T+ LV P PCC PTK++
Sbjct: 327 W-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCTPTKMSP 379
Query: 427 ISVLYFDDSSNVILKKYRNMVVRSCGC 453
I++LYF+D +I K MVV CGC
Sbjct: 380 INMLYFNDKQQIIYGKIPGMVVDRCGC 406
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 92.8 bits (229), Expect = 6e-19
Identities = 62/207 (29%), Positives = 87/207 (42%), Gaps = 35/207 (16%)
Query: 247 WLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFK 306
W D+ +W+ P++NLG+++ A +G + V G G PF+
Sbjct: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG----PGEDGLNPFL----- 253
Query: 307 ASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLG 366
V+ + K R+ + S S C ++ L V F G
Sbjct: 254 -------EVKVTDTPKRSRRDFGLDCDEHSTESR------------CCRYPLTVDFEAFG 294
Query: 367 WQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNA 426
W DWIIAP+ Y A YC GEC F T+ LVH P PCC PTK++
Sbjct: 295 W-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSP 347
Query: 427 ISVLYFDDSSNVILKKYRNMVVRSCGC 453
I++LYF+ +I K MVV CGC
Sbjct: 348 INMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/306 (23%), Positives = 130/306 (42%), Gaps = 42/306 (13%)
Query: 174 RRHYKEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADL 232
R +++ RFD++ + + + AEFR+++ N + +I +YQI+K
Sbjct: 152 RPYFRIVRFDVSAMEKNASNLVKAEFRVFR-LQNPKARVPEQRIELYQILKSKDLTSPTQ 210
Query: 233 FLLDTRKAQALDVG-WLVFDITVTSNHWVINPQNNLGLQLCAET--------------GD 277
+D++ + G WL FD+T + W+ + NLG ++
Sbjct: 211 RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNK 270
Query: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQN-------RNKSS 330
+ + AG+ G + + ++S R N K + +
Sbjct: 271 SEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLE 320
Query: 331 SHQDSSRMSSVGD--YNTSEQKQACKKHELYVSF-RDLGWQDWIIAPEGYAAFYCDGECS 387
S Q + R D Y + C LY+ F RDLGW+ WI P+GY A +C G C
Sbjct: 321 SQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP 379
Query: 388 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV 447
+ ++ T H+ V +L + + P+ PCC L +++LY+ + I ++ NM+
Sbjct: 380 YLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMI 435
Query: 448 VRSCGC 453
V+SC C
Sbjct: 436 VKSCKC 441
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/306 (23%), Positives = 130/306 (42%), Gaps = 42/306 (13%)
Query: 174 RRHYKEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADL 232
R +++ RFD++ + + + AEFR+++ N + +I +YQI+K
Sbjct: 124 RPYFRIVRFDVSAMEKNASNLVKAEFRVFR-LQNPKARVPEQRIELYQILKSKDLTSPTQ 182
Query: 233 FLLDTRKAQALDVG-WLVFDITVTSNHWVINPQNNLGLQLCAET--------------GD 277
+D++ + G WL FD+T + W+ + NLG ++
Sbjct: 183 RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNK 242
Query: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQN-------RNKSS 330
+ + AG+ G + + ++S R N K + +
Sbjct: 243 SEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLE 292
Query: 331 SHQDSSRMSSVGD--YNTSEQKQACKKHELYVSF-RDLGWQDWIIAPEGYAAFYCDGECS 387
S Q + R D Y + C LY+ F RDLGW+ WI P+GY A +C G C
Sbjct: 293 SQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP 351
Query: 388 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV 447
+ ++ T H+ V +L + + P+ PCC L +++LY+ + I ++ NM+
Sbjct: 352 YLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMI 407
Query: 448 VRSCGC 453
V+SC C
Sbjct: 408 VKSCKC 413
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 85.5 bits (210), Expect = 9e-17
Identities = 42/105 (40%), Positives = 59/105 (56%), Gaps = 5/105 (4%)
Query: 353 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATN--HAIV--QTLVHL 408
C + + ++ FR +GW DWIIAP GY YC+G C L + + H V Q +
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRG 362
Query: 409 MFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
+ P V CC PTKL+ +S+LYFDD N++ + NM+V CGC
Sbjct: 363 LNPGTV-NSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 85.1 bits (209), Expect = 1e-16
Identities = 75/303 (24%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 178 KEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLD 236
K FRF+++ + + AEFR+ + + + NE +I ++QI++ + ++
Sbjct: 130 KVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAKQRYIGG 188
Query: 237 TRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE--------TGD-----GRSINV 283
WL FD+T T W++ ++NLGL++ GD + +
Sbjct: 189 KNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEI 248
Query: 284 KSAGLV-------GRQGPQSKQ-----PFMVAFFKASEVLLRSVRAANKRKNQNRNKSSS 331
K G+ G G KQ P ++ +++ R N + R K +
Sbjct: 249 KFKGVDNEDDHGRGDLGRLKKQKDHHNPHLIL------MMIPPHRLDNPGQGGQRKKRAL 302
Query: 332 HQDSSRMSSVGDYNTSEQKQACKKHELYVSFR-DLGWQDWIIAPEGYAAFYCDGECSFPL 390
+ Y ++ C LY+ FR DLGW+ W+ P+GY A +C G C +
Sbjct: 303 DTN---------YCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLR 352
Query: 391 NAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS 450
+A T H+ V L + + P+ PCC P L +++LY+ + + ++ NMVV+S
Sbjct: 353 SAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKS 408
Query: 451 CGC 453
C C
Sbjct: 409 CKC 411
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 84.7 bits (208), Expect = 2e-16
Identities = 40/103 (38%), Positives = 59/103 (57%), Gaps = 2/103 (1%)
Query: 353 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPL--NAHMNATNHAIVQTLVHLMF 410
C + + YV F++LGW+DWI+ PEGY YC G+C L + + A+ H+ V +L+
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANN 306
Query: 411 PDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
P CC PT +S+LY D + NV+ +MVV +CGC
Sbjct: 307 PWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 83.6 bits (205), Expect = 3e-16
Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 11/169 (6%)
Query: 292 QGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQ-- 349
QGP ++ ++ + E R+++ R + + SS + + +N SE
Sbjct: 289 QGPDQERS--LSAYPVGEEAAEDGRSSHHRHRRGQETVSS--ELKKPLGPASFNLSEYFR 344
Query: 350 -----KQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404
+ C+ H+ +SF L W +WI+AP Y YC G+C + + H +VQ
Sbjct: 345 QFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQN 404
Query: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
+++ VP+P C P K + +SVL + ++ K+Y +M+ C C
Sbjct: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 79.7 bits (195), Expect = 5e-15
Identities = 39/105 (37%), Positives = 56/105 (53%), Gaps = 4/105 (3%)
Query: 353 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNA--HMNATNHAIVQTLVHLMF 410
C + E +V FR++GW DWII PEGYA +C G+C + + A+ H V L+
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306
Query: 411 PDHVP--KPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
CC PT +S+LY+D SN++ +MVV +CGC
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,203,576
Number of Sequences: 37866
Number of extensions: 765097
Number of successful extensions: 2366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2266
Number of HSP's gapped (non-prelim): 61
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.