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Search of human proteins with 117500790
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117500790 FERM domain containing 3 [Homo sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117500790 FERM domain containing 3 [Homo sapiens] 1217 0.0
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 583 e-166
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 261 1e-69
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 257 2e-68
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 256 5e-68
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 255 7e-68
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 254 1e-67
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 254 1e-67
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 254 1e-67
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 254 2e-67
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 254 2e-67
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 251 1e-66
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 233 5e-61
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 231 1e-60
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 221 2e-57
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 213 4e-55
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 209 6e-54
gi|34916000 FERM domain containing 7 [Homo sapiens] 182 6e-46
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 178 1e-44
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 164 2e-40
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 164 2e-40
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 131 2e-30
gi|38788243 myosin regulatory light chain interacting protein [H... 121 2e-27
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 120 5e-27
gi|161702986 ezrin [Homo sapiens] 115 1e-25
gi|21614499 ezrin [Homo sapiens] 115 1e-25
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 113 6e-25
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 113 6e-25
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 113 6e-25
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 113 6e-25
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 1217 bits (3149), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDH 60
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDH
Sbjct: 1 MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDH 60
Query: 61 ICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIK 120
ICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIK
Sbjct: 61 ICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIK 120
Query: 121 EELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFP 180
EELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFP
Sbjct: 121 EELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFP 180
Query: 181 KQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFT 240
KQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFT
Sbjct: 181 KQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFT 240
Query: 241 AAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKC 300
AAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKC
Sbjct: 241 AAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKC 300
Query: 301 GVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANI 360
GVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANI
Sbjct: 301 GVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANI 360
Query: 361 TQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKA 420
TQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKA
Sbjct: 361 TQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKA 420
Query: 421 AREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDT 480
AREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDT
Sbjct: 421 AREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDT 480
Query: 481 DSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLL 540
DSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLL
Sbjct: 481 DSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLL 540
Query: 541 FVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS 597
FVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS
Sbjct: 541 FVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS 597
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 583 bits (1503), Expect = e-166
Identities = 297/574 (51%), Positives = 393/574 (68%), Gaps = 14/574 (2%)
Query: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
S S +SL +E CT+RLLDDSE +C IQR+ KGQ+L D +C++ +LLEKDYFGIR+VDP+
Sbjct: 7 SGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPD 66
Query: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
KQRHWLE KS+ KQ+++ PP+TMCFRVKFYP +P +KEE+TRYL++LQIKRD++HGRL
Sbjct: 67 KQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRL 126
Query: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
LC SDAA L A I+QAE+GDYD +HPE Y S+F+ FPK S+KLERKI EIHK EL GQ
Sbjct: 127 LCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQ 186
Query: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
+P +E N L KA TLETYGVDPHPCKD +G FL FT GFVV QGNKR+H IKW +V
Sbjct: 187 TPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEV 246
Query: 262 CKLKFEGKTFYVIGTQK-EKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVS 320
KLKFEGKTFY+ +QK EKK +L + TP ACKHLWKCG+ENQAFYK KSSQ++TVS
Sbjct: 247 TKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVS 306
Query: 321 SSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPL 380
SS +FFKGSRFRYSG+VAKEV+E+S+KI+REPPE+HRA + SRS S I P
Sbjct: 307 SSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPS------ITHGPR 360
Query: 381 QPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPL 440
+P + + + EG+ ++ S P+ S+S + + + E
Sbjct: 361 LSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSN---ERVA 417
Query: 441 TISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADENAFLIAEEEE 500
I++ Y+P+ S+LPTPV + ++++ ++ E+ E++ + E E
Sbjct: 418 VIADEAYSPADSVLPTPVAEHSLELML---LSRQINGATCSIEEEKESEASTPTATEVEA 474
Query: 501 LKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLLFVFPLLLLLLESGIDLSFLC 560
L RAL + +VN V S RLL+V +GLL + LL++L ES +D++F
Sbjct: 475 LGGELRALCQGHS-GPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFR 533
Query: 561 EIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYML 594
+IRQTPEFEQFHY+Y+CPL+ W A K+ ++ +L
Sbjct: 534 DIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLL 567
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 261 bits (667), Expect = 1e-69
Identities = 136/347 (39%), Positives = 204/347 (58%), Gaps = 9/347 (2%)
Query: 30 QEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEP 89
+ M+C + LLD SE +C +++ ++GQ L D +C + +LLEKDYFG+ Y D E Q++WL+P
Sbjct: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
Query: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
K I KQ+++ + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A
Sbjct: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
Query: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
LG+ VQ+ELGDYDPDE +YISEF P +++LE K++E+HK+ RG +P AE +
Sbjct: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSH-RGMTPAEAEMH 285
Query: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
L A L YGVD H KDS G LG A+G ++++ RI+ WP V K+ ++
Sbjct: 286 FLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRN 345
Query: 270 TFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326
FY+ G ++ ++ + F A K LWK VE+ F++ + K
Sbjct: 346 NFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL----LPEAPPKKFLT 401
Query: 327 KGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQL 373
GS+FRYSG+ + AS+ I R P R++ + S SL+ ++
Sbjct: 402 LGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEV 448
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 257 bits (657), Expect = 2e-68
Identities = 155/470 (32%), Positives = 250/470 (53%), Gaps = 20/470 (4%)
Query: 32 MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91
M C + LLDD+ C +++ KGQ L+ +C + +LLE+DYFG+ D + WL+ K
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 92 SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151
I KQ++ P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL CSF+ A L
Sbjct: 61 EIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211
G+ +Q+ELGDYDP+ H +Y+S+F++ P Q+++LE K++E+HK+ R +P A+ L
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQADLEFL 178
Query: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTF 271
A L YGVD H KD G LG ++G +V++ RI+ WP V K+ ++ +F
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
Query: 272 YV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
++ G Q++ ++ + F + A K LWK VE+ F++ + T+ SK G
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALG 295
Query: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPS-P 387
S+FRYSG+ + +AS+ I R P R R+S SL+ ++ P S P
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAP 353
Query: 388 SEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEED-------KIKEEPL 440
+ + ++ G GV + P VKA + ED P E+ + K K E L
Sbjct: 354 AITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERL 412
Query: 441 TISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADE 490
E +Y ++L+ +D + ++ S EL++ +S + E
Sbjct: 413 D-GENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 461
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 256 bits (653), Expect = 5e-68
Identities = 142/406 (34%), Positives = 225/406 (55%), Gaps = 12/406 (2%)
Query: 32 MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91
M C + LLDD+ C +++ KGQ L+ +C + +LLE+DYFG+ D + WL+ K
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 92 SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151
I KQ++ P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL CSF+ A L
Sbjct: 61 EIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211
G+ +Q+ELGDYDP+ H +Y+S+F++ P Q+++LE K++E+HK+ R +P A+ L
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQADLEFL 178
Query: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTF 271
A L YGVD H KD G LG ++G +V++ RI+ WP V K+ ++ +F
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
Query: 272 YV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
++ G Q++ ++ + F + A K LWK VE+ F++ + T+ SK G
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALG 295
Query: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPS-P 387
S+FRYSG+ + +AS+ I R P R R+S SL+ ++ P S P
Sbjct: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAP 353
Query: 388 SEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEED 433
+ + ++ G GV + P VKA + ED P E+ +
Sbjct: 354 AITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAE 398
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 255 bits (652), Expect = 7e-68
Identities = 163/439 (37%), Positives = 229/439 (52%), Gaps = 29/439 (6%)
Query: 34 CTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSI 93
C + LLD +++S + ++ KGQ L D I + L+E DYFG+R++D + HWL+ KSI
Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104
Query: 94 FKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGA 153
KQ+K PY + RVKFY EP ++EELTRYL LQ+K+DI G+L C F A L A
Sbjct: 105 KKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAA 164
Query: 154 CIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLK 213
+QAELGDYD EH +SEF P Q++++E I E K E RGQ+P AE N L K
Sbjct: 165 YNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWK-EYRGQTPAQAETNYLNK 223
Query: 214 AHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV 273
A LE YGVD H K G LG T G +VF+G+ +I L WP + +L F+ +
Sbjct: 224 AKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTL 283
Query: 274 IGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
+ + KE++ F P ACKHLWKC VE+ AF++ Q K+ S G
Sbjct: 284 VVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQ-KSSHRSGFIRLG 342
Query: 329 SRFRYSGKVAKEVVEA-----SSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPL 383
SRFRYSGK + + S+ +R P + + Q ++ + ++L ++
Sbjct: 343 SRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEELSVHNN----- 397
Query: 384 LPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREY--EDPPSEEEDKIKEEPLT 441
S + G LP +P ISS+PV E + P +++ D+ K PL
Sbjct: 398 -VSTQSNGSQQAWGMRSALP-----VSPSISSAPVPVEIENLPQSPGTDQHDR-KCIPLN 450
Query: 442 ISELVYNPSASLLPTPVDD 460
I L S LL + D
Sbjct: 451 IDLL---NSPDLLEATIGD 466
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 254 bits (650), Expect = 1e-67
Identities = 135/352 (38%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
S V ++ ++C + LLD +E SC +++ KGQ L D +C + +LLEKDYFG+ + +
Sbjct: 208 SQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESP 267
Query: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
+Q++WL+P K I +Q++ + P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL
Sbjct: 268 EQKNWLDPAKEIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRL 326
Query: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
CSF A LG+ +QAELGDYDP+EH +SEF+ P Q+++LE K+ E+HK RG
Sbjct: 327 PCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGL 385
Query: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
SP A+ L A L YGVD H KDS G LG A G ++++ RI+ WP +
Sbjct: 386 SPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKI 445
Query: 262 CKLKFEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKT 318
K+ ++ FY+ ++ ++ + F A K LWK VE+ FY+ Q
Sbjct: 446 LKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQ--- 502
Query: 319 VSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
+K GS+FRYSG+ + +AS+ I R P R + R S SL+
Sbjct: 503 PPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERT--SSKRVSRSLD 552
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 254 bits (650), Expect = 1e-67
Identities = 135/352 (38%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
S V ++ ++C + LLD +E SC +++ KGQ L D +C + +LLEKDYFG+ + +
Sbjct: 208 SQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESP 267
Query: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
+Q++WL+P K I +Q++ + P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL
Sbjct: 268 EQKNWLDPAKEIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRL 326
Query: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
CSF A LG+ +QAELGDYDP+EH +SEF+ P Q+++LE K+ E+HK RG
Sbjct: 327 PCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGL 385
Query: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
SP A+ L A L YGVD H KDS G LG A G ++++ RI+ WP +
Sbjct: 386 SPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKI 445
Query: 262 CKLKFEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKT 318
K+ ++ FY+ ++ ++ + F A K LWK VE+ FY+ Q
Sbjct: 446 LKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQ--- 502
Query: 319 VSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
+K GS+FRYSG+ + +AS+ I R P R + R S SL+
Sbjct: 503 PPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERT--SSKRVSRSLD 552
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 254 bits (650), Expect = 1e-67
Identities = 135/352 (38%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
S V ++ ++C + LLD +E SC +++ KGQ L D +C + +LLEKDYFG+ + +
Sbjct: 208 SQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESP 267
Query: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
+Q++WL+P K I +Q++ + P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL
Sbjct: 268 EQKNWLDPAKEIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRL 326
Query: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
CSF A LG+ +QAELGDYDP+EH +SEF+ P Q+++LE K+ E+HK RG
Sbjct: 327 PCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGL 385
Query: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
SP A+ L A L YGVD H KDS G LG A G ++++ RI+ WP +
Sbjct: 386 SPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKI 445
Query: 262 CKLKFEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKT 318
K+ ++ FY+ ++ ++ + F A K LWK VE+ FY+ Q
Sbjct: 446 LKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQ--- 502
Query: 319 VSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
+K GS+FRYSG+ + +AS+ I R P R + R S SL+
Sbjct: 503 PPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERT--SSKRVSRSLD 552
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 254 bits (649), Expect = 2e-67
Identities = 130/340 (38%), Positives = 196/340 (57%), Gaps = 9/340 (2%)
Query: 34 CTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSI 93
C + LLD SE C +++ +GQ L D +C + +LLEKDYFG+ + D + Q++WL+P+K I
Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
Query: 94 FKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGA 153
KQ+++ P + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A LG+
Sbjct: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
Query: 154 CIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLK 213
VQAELGDYD +EH NY+SE P Q+++LE +I+E+HK RG +P AE + L
Sbjct: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRGMTPGEAEIHFLEN 214
Query: 214 AHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV 273
A L YGVD H KDS G LG A G ++++ RI+ WP + K+ ++ FY+
Sbjct: 215 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 274
Query: 274 ---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSR 330
G ++ ++ + F + K LWK +E+ F++ GS+
Sbjct: 275 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP----PPKGFLVMGSK 330
Query: 331 FRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
FRYSG+ + +AS+ I R P R++ + S SL+
Sbjct: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLD 370
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 254 bits (649), Expect = 2e-67
Identities = 130/340 (38%), Positives = 196/340 (57%), Gaps = 9/340 (2%)
Query: 34 CTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSI 93
C + LLD SE C +++ +GQ L D +C + +LLEKDYFG+ + D + Q++WL+P+K I
Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
Query: 94 FKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGA 153
KQ+++ P + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A LG+
Sbjct: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
Query: 154 CIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLK 213
VQAELGDYD +EH NY+SE P Q+++LE +I+E+HK RG +P AE + L
Sbjct: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRGMTPGEAEIHFLEN 276
Query: 214 AHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV 273
A L YGVD H KDS G LG A G ++++ RI+ WP + K+ ++ FY+
Sbjct: 277 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 336
Query: 274 ---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSR 330
G ++ ++ + F + K LWK +E+ F++ GS+
Sbjct: 337 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP----PPKGFLVMGSK 392
Query: 331 FRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
FRYSG+ + +AS+ I R P R++ + S SL+
Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLD 432
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 251 bits (642), Expect = 1e-66
Identities = 164/494 (33%), Positives = 255/494 (51%), Gaps = 32/494 (6%)
Query: 27 SLSQEMRCTIRLLDDSEISCHIQRE-----TKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
++ +E C + LLD+S+++ Q++ TKG ++DH+ ++ +L+E DYFG+RY D
Sbjct: 6 AVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRS 65
Query: 82 KQRHWLEPNKSIFKQ---MKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFH 138
Q +WL+P K++ + + T PPYT+ F +KFY +P K+KEE+TRY +LQ+K+D+
Sbjct: 66 HQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQ 125
Query: 139 GRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNEL 198
GRL C + AA LGA +Q+ELGDYDP +H Y+SE+ P Q ++LE I IHK L
Sbjct: 126 GRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKT-L 184
Query: 199 RGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKW 258
GQ P AE N L A +LE YGVD HP + FLG T G VV++ K++ W
Sbjct: 185 MGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFW 244
Query: 259 PDVCKLKFEGKTFYVIGTQKE-KKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317
P + K+ F+ F + K+ + F + ACKHLWKC VE+ F++ + ++
Sbjct: 245 PRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPE-NESN 303
Query: 318 TVSSSKIFFKGSRF--RYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLII 375
++S F R+ RYSG+ A ++ S IQ P+ N+T+SRS + I
Sbjct: 304 SLSRKLSKFGSIRYKHRYSGRTALQMSRDLS-IQLPRPD---QNVTRSRS--KTYPKRIA 357
Query: 376 NMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKI 435
+P + S E EG + +I+ SPVK+ ++ ++ S + +
Sbjct: 358 QTQPAESNSISRITANMENGENEG---------TIKIIAPSPVKSFKKAKNENSPDTQRS 408
Query: 436 KEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADENAFLI 495
K P + L +P D + R D DS + + A
Sbjct: 409 KSHAPWEEN---GPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVRR-RKAHNS 464
Query: 496 AEEEELKEARRALS 509
E+ +LK+ RR+ S
Sbjct: 465 GEDSDLKQRRRSRS 478
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 233 bits (593), Expect = 5e-61
Identities = 144/432 (33%), Positives = 215/432 (49%), Gaps = 45/432 (10%)
Query: 23 SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEK 82
S+ + + C + LLD +E+S + + KGQ L D I + L+E DYFG++++D +
Sbjct: 76 SAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQ 135
Query: 83 QRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLL 142
HWL+ K I KQMK P Y + FRVK+Y EP ++EE TRYL LQ++ DI G+L
Sbjct: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
Query: 143 CSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQS 202
C + A L A +QAELG+ + EH +SEF P Q++ +E I + K E RG+S
Sbjct: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKS 254
Query: 203 PPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVC 262
P AE + L KA LE YGVD H + G LG T G ++F+G +I L WP +
Sbjct: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314
Query: 263 KLKFEGKTFYVIGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317
K+ F+ ++ + +E++ F + CKHLWKC VE+ AF++ K
Sbjct: 315 KMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSK 374
Query: 318 TVSSSKIFFKGSRFRYSGKVAKEVVEAS-----SKIQREPPEVH--RANITQSRSS---- 366
+ + S GSRFR+SG+ + S S +R+P + + R + T S+
Sbjct: 375 S-NRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIA 433
Query: 367 -----------HSLNKQLIINMEPLQPL-----------LPSPSEQEEELPLGEGVPLPK 404
H+ Q N+ P QP LPSP L + +P
Sbjct: 434 AQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVSYPLPSP-----VLSSSDRLPFGI 488
Query: 405 EENISAPLISSS 416
EEN P ++++
Sbjct: 489 EENGGTPFLTAA 500
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 231 bits (589), Expect = 1e-60
Identities = 131/369 (35%), Positives = 195/369 (52%), Gaps = 14/369 (3%)
Query: 23 SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEK 82
S+ + + C + LLD +E+S + + KGQ L D I + L+E DYFG++++D +
Sbjct: 76 SAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQ 135
Query: 83 QRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLL 142
HWL+ K I KQMK P Y + FRVK+Y EP ++EE TRYL LQ++ DI G+L
Sbjct: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
Query: 143 CSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQS 202
C + A L A +QAELG+ + EH +SEF P Q++ +E I + K E RG+S
Sbjct: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKS 254
Query: 203 PPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVC 262
P AE + L KA LE YGVD H + G LG T G ++F+G +I L WP +
Sbjct: 255 PAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314
Query: 263 KLKFEGKTFYVIGTQ-----KEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIK 317
K+ F+ ++ + +E++ F + CKHLWKC VE+ AF++ K
Sbjct: 315 KMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSK 374
Query: 318 TVSSSKIFFKGSRFRYSGKVAKEVVEAS-----SKIQREPPEVH--RANITQSRSSHSLN 370
+ + S GSRFR+SG+ + S S +R+P + + R + T S+ +
Sbjct: 375 S-NRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIA 433
Query: 371 KQLIINMEP 379
QL P
Sbjct: 434 AQLCSKTNP 442
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 221 bits (562), Expect = 2e-57
Identities = 117/318 (36%), Positives = 184/318 (57%), Gaps = 7/318 (2%)
Query: 31 EMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQR-HWLEP 89
E+ C I LLD++ + + + +GQ L+D + + L E+DYFG++ D WL+P
Sbjct: 28 EVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDP 87
Query: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
NK I KQ+K PY++ FRVKF+ +P K++EE TRY +LQIK+DI GRL C + AA
Sbjct: 88 NKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAA 147
Query: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
L + VQ+ELGDYD E+ Y+S++ P Q Q E++I ++H+ + G SP AEFN
Sbjct: 148 LLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHI-GLSPAEAEFN 206
Query: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
L A TLE YGV+ H +D + +G + G ++++ R++ W + K+ F+ K
Sbjct: 207 YLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCK 266
Query: 270 TFYVIGTQKE----KKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIF 325
F+ I +KE ++ +L F+ ACK+LWK VE+ F++ + + + F
Sbjct: 267 QFF-IQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYF 325
Query: 326 FKGSRFRYSGKVAKEVVE 343
GS+FRY G+ + V+
Sbjct: 326 TLGSKFRYCGRTEVQSVQ 343
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 213 bits (542), Expect = 4e-55
Identities = 129/382 (33%), Positives = 204/382 (53%), Gaps = 27/382 (7%)
Query: 86 WLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSF 145
WL+ K I KQ++ P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL CSF
Sbjct: 229 WLDSAKEIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
Query: 146 SDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPV 205
+ A LG+ +Q+ELGDYDP+ H +Y+S+F++ P Q+++LE K++E+HK+ R +P
Sbjct: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQ 346
Query: 206 AEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLK 265
A+ L A L YGVD H KD G LG ++G +V++ RI+ WP V K+
Sbjct: 347 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 406
Query: 266 FEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSS 322
++ +F++ G Q++ ++ + F + A K LWK VE+ F++ + T+ S
Sbjct: 407 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKS 463
Query: 323 KIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQP 382
K GS+FRYSG+ + +AS+ I R P R R+S SL+ ++ P
Sbjct: 464 KFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSP 521
Query: 383 LLPS-PSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEE---------- 431
S P+ + ++ G GV + P VKA + ED P E+
Sbjct: 522 RPTSAPAITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK 580
Query: 432 -----EDKIKEEPLTISELVYN 448
+++IK+ +ISEL N
Sbjct: 581 DLDKSQEEIKKHHASISELKKN 602
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 209 bits (532), Expect = 6e-54
Identities = 143/425 (33%), Positives = 221/425 (52%), Gaps = 34/425 (8%)
Query: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
I++LDD++ + + + G+ L+D +CN+ +L+E DYFG+ + D +K WL+ K I K
Sbjct: 44 IQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVK 103
Query: 96 QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155
Q++ + F VKF+P + +++EELTRYL LQ+K+D+ GRL C+ + AA L + I
Sbjct: 104 QIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHI 163
Query: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215
VQ+E+GD+D + ++++ + P+Q LE KIVE H N + GQ+P ++F LL A
Sbjct: 164 VQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHI-GQTPAESDFQLLEIAR 220
Query: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIG 275
LE YG+ HP KD GT L G +VFQG +I+ W V KL F+ K F +
Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280
Query: 276 TQKEKKA---MLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332
A L F ++ CK WK VE+ AF++ + + K +F +GS FR
Sbjct: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPK--PKPVLFSRGSSFR 338
Query: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQ-LIINMEPLQPLLPSPSEQE 391
+SG+ K+V++ + + + R + ++ S SL Q +N E L+ S+Q
Sbjct: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH-SKIHSIRSLASQPTELNSEVLE-----QSQQS 392
Query: 392 EELPLGEGVPLP--------KEENISAPLISSSPVKAARE-----------YEDPPSEEE 432
L GEG P KE +SA S P A R P EEE
Sbjct: 393 TSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEE 452
Query: 433 DKIKE 437
+ +K+
Sbjct: 453 EVVKD 457
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 182 bits (463), Expect = 6e-46
Identities = 139/459 (30%), Positives = 219/459 (47%), Gaps = 27/459 (5%)
Query: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
++ LDDS+ + +++ G+ L + C++ +L EK+YFG+ + WLE K I K
Sbjct: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
Query: 96 QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155
Q+K F VKF+P +P ++EELTRYL LQIK+D+ GRL CS + A + + I
Sbjct: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
Query: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215
+Q+ELGD+ +E ++++ P Q LE KI+ H+ + G+SP ++ LL A
Sbjct: 126 LQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
Query: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV-- 273
L+ YG+ PHP D G L G +V +GN +I+ W + KL F+ K F +
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 274 -IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332
K L F ++ ACK WK VE AF++ S + K+ + + KGS FR
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
Query: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEE 392
YSG+ ++++E K + + R + LL S+Q E
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSS--------PDLLSDVSKQVE 352
Query: 393 ELPLGEGVPLPKEEN---ISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNP 449
+L L G + N S P++ S +A E E K + +P + + +
Sbjct: 353 DLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQ---SQ 409
Query: 450 SASLLP----TPVDDDEIDMLFDCPSRLELEREDTDSFE 484
S+S P PV + E + D P + ER SF+
Sbjct: 410 SSSSFPFIYMDPVFNTEPNPNPD-PRDIFSERSSLSSFQ 447
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 178 bits (451), Expect = 1e-44
Identities = 129/393 (32%), Positives = 202/393 (51%), Gaps = 15/393 (3%)
Query: 30 QEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEP 89
+ + ++LLD++ I+ + GQ L+ + +L+E DYFG+ + + + WLEP
Sbjct: 42 KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
Query: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
K I +Q++ + VKF+P +P +++EE TRYL LQ+KRD+ RL C+ + AA
Sbjct: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
Query: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
L + ++Q+E+GDYD + ++ E P Q LE KI+E H+ + GQ+P ++F
Sbjct: 162 LLTSHLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHV-GQTPAESDFQ 218
Query: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
+L A LE YG+ H D GT L + G +VFQG +I+ W V KL F+ K
Sbjct: 219 VLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRK 278
Query: 270 TFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326
F + + L F + CK+ WK VE F++ Q K + + F
Sbjct: 279 RFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLL--DQPKPKAKAVFFS 336
Query: 327 KGSRFRYSGKVAKEVVE--ASSKIQREPPE-VHRANITQSRS-SHSLNKQLIINMEPLQ- 381
+GS FRYSG+ K++V+ S ++R P E H T R+ + L KQ I E L+
Sbjct: 337 RGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRT 396
Query: 382 PLLPSPSEQEEELPLGEGVP--LPKEENISAPL 412
P PS + L VP LP+ ++ S+ L
Sbjct: 397 PASPSSANAFYSLSPSTLVPSGLPEFKDSSSSL 429
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 164 bits (416), Expect = 2e-40
Identities = 95/304 (31%), Positives = 161/304 (52%), Gaps = 5/304 (1%)
Query: 31 EMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQR-HWLEP 89
E+ C+I LD + + ++ GQ L+D + N+ + EK+YFG+++ D WLE
Sbjct: 28 EVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEA 87
Query: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
+K+I KQ+K P T+ FRV+F+ +P +++E TR+L +LQ+K DI GRL C + A
Sbjct: 88 SKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV 147
Query: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
L + VQ+ GDY+ H Y+S+ P Q++ K+ +H+ G AE
Sbjct: 148 VLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQH-SGLKQSEAESC 206
Query: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
+ A TL+ YGV+ H +D +G +AG V++ W ++ K+ F+ K
Sbjct: 207 YINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRK 266
Query: 270 TFYVIGTQKE---KKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326
F++ QK+ ++ ++AF+ +CK+LWK VE+ F++ K + S+ +
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWT 326
Query: 327 KGSR 330
GSR
Sbjct: 327 MGSR 330
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 164 bits (416), Expect = 2e-40
Identities = 95/304 (31%), Positives = 161/304 (52%), Gaps = 5/304 (1%)
Query: 31 EMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQR-HWLEP 89
E+ C+I LD + + ++ GQ L+D + N+ + EK+YFG+++ D WLE
Sbjct: 28 EVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEA 87
Query: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
+K+I KQ+K P T+ FRV+F+ +P +++E TR+L +LQ+K DI GRL C + A
Sbjct: 88 SKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV 147
Query: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
L + VQ+ GDY+ H Y+S+ P Q++ K+ +H+ G AE
Sbjct: 148 VLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQH-SGLKQSEAESC 206
Query: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
+ A TL+ YGV+ H +D +G +AG V++ W ++ K+ F+ K
Sbjct: 207 YINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRK 266
Query: 270 TFYVIGTQKE---KKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326
F++ QK+ ++ ++AF+ +CK+LWK VE+ F++ K + S+ +
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWT 326
Query: 327 KGSR 330
GSR
Sbjct: 327 MGSR 330
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 131 bits (330), Expect = 2e-30
Identities = 88/331 (26%), Positives = 166/331 (50%), Gaps = 21/331 (6%)
Query: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
I+LL++ + + E+ GQ ++ + L E YF + Y + + QR W++ K + K
Sbjct: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKK 86
Query: 96 QMKTHP-PYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGAC 154
Q+ + T+ F V FY ++++E+TRY YLQ+K+DI G + C+ A L
Sbjct: 87 QLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGL 146
Query: 155 IVQAELGDYDPDEHPENYISEFEIFP-------KQSQKLERKIVEIHKNELRGQSPPVAE 207
VQA+ GD+D E ++++ +F +FP K ++ +K+ +H+ + RG + P AE
Sbjct: 147 AVQADFGDFDQYE-SQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQ-KYRGLTAPDAE 204
Query: 208 FNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLI-KWPDVCKLKF 266
+ + ++ YG + +P KDS G+ +G G V N R ++ +W D+ +
Sbjct: 205 MLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMS- 263
Query: 267 EGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSS-QIKTVSSSKIF 325
K+F+ + K+ + F T K++W+ V FY+ + + Q +TV+ + I
Sbjct: 264 HNKSFFAL-ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPI- 321
Query: 326 FKGSRFRYSGKVAKEVVEASSKIQREPPEVH 356
R R S +++ + + + PP++H
Sbjct: 322 ----RRRSSSRMS--LPKPQPYVMPPPPQLH 346
>gi|38788243 myosin regulatory light chain interacting protein [Homo
sapiens]
Length = 445
Score = 121 bits (304), Expect = 2e-27
Identities = 83/281 (29%), Positives = 133/281 (47%), Gaps = 8/281 (2%)
Query: 32 MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91
M C + D + ++ + G+ ++ +C ++E DYFG+++ + + WL
Sbjct: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
Query: 92 SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151
I +QM PY + RVKF+ EP I +E TR++ +L IK + G LLCS A L
Sbjct: 61 RISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
Query: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQ-SQKLERKIVEIHKNELRGQSPPVAEFNL 210
A + Q + GDY+ + NY E+ K+ S IV HK EL G S AE+ +
Sbjct: 120 SALLAQTKFGDYNQNTAKYNY---EELCAKELSSATLNSIVAKHK-ELEGTSQASAEYQV 175
Query: 211 LLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGN-KRIHLIKWPDVCKLKFEGK 269
L +E YG++ H +DS G +G G + + + I+ I +P V GK
Sbjct: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
Query: 270 TFYVIGTQKE-KKAMLAFHTSTPAACKHLWKCGVENQAFYK 309
Y+ T++ +L F + A L++ E AFY+
Sbjct: 236 NVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 120 bits (300), Expect = 5e-27
Identities = 82/286 (28%), Positives = 135/286 (47%), Gaps = 13/286 (4%)
Query: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
IRLLD + I C + E+ GQ ++ + L E YFG+ ++ +Q W+E K + K
Sbjct: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKK 84
Query: 96 QM-KTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGAC 154
+ K + F V FY +++E TRY YLQ+K+D+ GRL C+ L
Sbjct: 85 HLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGL 144
Query: 155 IVQAELGDYDPDEHPENYISEFEIFPKQ-------SQKLERKIVEIHKNELRGQSPPVAE 207
VQA+ GDY+ + ++++ E+ +FP ++L +K+ + HK G P AE
Sbjct: 145 AVQADFGDYNQFD-SQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAH-SGILPAEAE 202
Query: 208 FNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAG-FVVFQGNKRIHLIKWPDVCKLKF 266
+ + L+ +G + P KD+ G LG G FV + ++ + +W D+ +
Sbjct: 203 LMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITH 262
Query: 267 EGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAK 312
T V KE+ A+ FHT K++ + FYK K
Sbjct: 263 NKSTILVELINKEETAL--FHTDDIENAKYISRLFATRHKFYKQNK 306
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 115 bits (287), Expect = 1e-25
Identities = 109/428 (25%), Positives = 185/428 (43%), Gaps = 23/428 (5%)
Query: 41 DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQ-MKT 99
D+E+ IQ T G+ L D + L E YFG+ YVD + WL+ +K + Q ++
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 100 HPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQA 158
P FR KFYP + + + +++T+ L +LQ+K I + C A LG+ VQA
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 159 ELGDYDPDEHPENYISEFEIFPKQ---SQKLER----KIVEIHKNELRGQSPPVAEFNLL 211
+ GDY+ + H Y+S + P++ KL R +++ E RG A L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHL---IKWPDVCKLKFEG 268
A LE YG++ K+ GT +LG A G +++ + ++ W ++ + F
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 269 KTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
K F VI +K F+ K + + + N Y + T+ ++ +
Sbjct: 253 KKF-VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPD--TIEVQQMKAQA 309
Query: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPS 388
++ ++ ++ +E K +RE V R R L +L E + S
Sbjct: 310 REEKHQKQLERQQLETEKK-RRE--TVEREKEQMMREKEELMLRLQDYEEKTKKAERELS 366
Query: 389 EQ-EEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELV- 446
EQ + L L E +EE A + + + A R E+ + D+IK + +EL
Sbjct: 367 EQIQRALQLEEERKRAQEE---AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAE 423
Query: 447 YNPSASLL 454
Y +LL
Sbjct: 424 YTAKIALL 431
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 115 bits (287), Expect = 1e-25
Identities = 109/428 (25%), Positives = 185/428 (43%), Gaps = 23/428 (5%)
Query: 41 DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQ-MKT 99
D+E+ IQ T G+ L D + L E YFG+ YVD + WL+ +K + Q ++
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 100 HPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQA 158
P FR KFYP + + + +++T+ L +LQ+K I + C A LG+ VQA
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 159 ELGDYDPDEHPENYISEFEIFPKQ---SQKLER----KIVEIHKNELRGQSPPVAEFNLL 211
+ GDY+ + H Y+S + P++ KL R +++ E RG A L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHL---IKWPDVCKLKFEG 268
A LE YG++ K+ GT +LG A G +++ + ++ W ++ + F
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 269 KTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
K F VI +K F+ K + + + N Y + T+ ++ +
Sbjct: 253 KKF-VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPD--TIEVQQMKAQA 309
Query: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPS 388
++ ++ ++ +E K +RE V R R L +L E + S
Sbjct: 310 REEKHQKQLERQQLETEKK-RRE--TVEREKEQMMREKEELMLRLQDYEEKTKKAERELS 366
Query: 389 EQ-EEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELV- 446
EQ + L L E +EE A + + + A R E+ + D+IK + +EL
Sbjct: 367 EQIQRALQLEEERKRAQEE---AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAE 423
Query: 447 YNPSASLL 454
Y +LL
Sbjct: 424 YTAKIALL 431
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 113 bits (282), Expect = 6e-25
Identities = 95/390 (24%), Positives = 176/390 (45%), Gaps = 20/390 (5%)
Query: 23 SSVKSLSQEMRCTIRLLD-DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
SS+K Q T+R++ D+E+ + + + KG+ L D +C L E +FG++Y +
Sbjct: 12 SSLKR-KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD 70
Query: 82 KQRHWLEPNKSIFKQ-MKTHPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHG 139
WL+ +K + + P T F KFYP + + +E+T++L +LQ+K+ I
Sbjct: 71 TVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 140 RLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKN--- 196
++ C + L + VQA+ GDYDP H ++++ E+ PK+ L + E+ +
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 197 ----ELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKR 252
E RG++ AE L A LE YGV+ ++ GT LG A G ++ R
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENR 249
Query: 253 IH---LIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFY- 308
+ W ++ + + K F + K K + F++S K + + + N +
Sbjct: 250 LTPKISFPWNEIRNISYSDKEFTIKPLDK-KIDVFKFNSSKLRVNKLILQLCIGNHDLFM 308
Query: 309 --KYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSS 366
+ A S +++ + + K + ++A+E + + +R E+ R + +
Sbjct: 309 RRRKADSLEVQQMKAQAREEKARKQMERQRLARE-KQMREEAERTRDELERRLLQMKEEA 367
Query: 367 HSLNKQLIINMEPLQPLLPSPSEQEEELPL 396
N+ L+ + E L EEE L
Sbjct: 368 TMANEALMRSEETADLLAEKAQITEEEAKL 397
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 113 bits (282), Expect = 6e-25
Identities = 95/390 (24%), Positives = 176/390 (45%), Gaps = 20/390 (5%)
Query: 23 SSVKSLSQEMRCTIRLLD-DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
SS+K Q T+R++ D+E+ + + + KG+ L D +C L E +FG++Y +
Sbjct: 12 SSLKR-KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD 70
Query: 82 KQRHWLEPNKSIFKQ-MKTHPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHG 139
WL+ +K + + P T F KFYP + + +E+T++L +LQ+K+ I
Sbjct: 71 TVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 140 RLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKN--- 196
++ C + L + VQA+ GDYDP H ++++ E+ PK+ L + E+ +
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 197 ----ELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKR 252
E RG++ AE L A LE YGV+ ++ GT LG A G ++ R
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENR 249
Query: 253 IH---LIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFY- 308
+ W ++ + + K F + K K + F++S K + + + N +
Sbjct: 250 LTPKISFPWNEIRNISYSDKEFTIKPLDK-KIDVFKFNSSKLRVNKLILQLCIGNHDLFM 308
Query: 309 --KYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSS 366
+ A S +++ + + K + ++A+E + + +R E+ R + +
Sbjct: 309 RRRKADSLEVQQMKAQAREEKARKQMERQRLARE-KQMREEAERTRDELERRLLQMKEEA 367
Query: 367 HSLNKQLIINMEPLQPLLPSPSEQEEELPL 396
N+ L+ + E L EEE L
Sbjct: 368 TMANEALMRSEETADLLAEKAQITEEEAKL 397
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 113 bits (282), Expect = 6e-25
Identities = 95/390 (24%), Positives = 176/390 (45%), Gaps = 20/390 (5%)
Query: 23 SSVKSLSQEMRCTIRLLD-DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
SS+K Q T+R++ D+E+ + + + KG+ L D +C L E +FG++Y +
Sbjct: 12 SSLKR-KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD 70
Query: 82 KQRHWLEPNKSIFKQ-MKTHPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHG 139
WL+ +K + + P T F KFYP + + +E+T++L +LQ+K+ I
Sbjct: 71 TVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 140 RLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKN--- 196
++ C + L + VQA+ GDYDP H ++++ E+ PK+ L + E+ +
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 197 ----ELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKR 252
E RG++ AE L A LE YGV+ ++ GT LG A G ++ R
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENR 249
Query: 253 IH---LIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFY- 308
+ W ++ + + K F + K K + F++S K + + + N +
Sbjct: 250 LTPKISFPWNEIRNISYSDKEFTIKPLDK-KIDVFKFNSSKLRVNKLILQLCIGNHDLFM 308
Query: 309 --KYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSS 366
+ A S +++ + + K + ++A+E + + +R E+ R + +
Sbjct: 309 RRRKADSLEVQQMKAQAREEKARKQMERQRLARE-KQMREEAERTRDELERRLLQMKEEA 367
Query: 367 HSLNKQLIINMEPLQPLLPSPSEQEEELPL 396
N+ L+ + E L EEE L
Sbjct: 368 TMANEALMRSEETADLLAEKAQITEEEAKL 397
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 113 bits (282), Expect = 6e-25
Identities = 95/390 (24%), Positives = 176/390 (45%), Gaps = 20/390 (5%)
Query: 23 SSVKSLSQEMRCTIRLLD-DSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
SS+K Q T+R++ D+E+ + + + KG+ L D +C L E +FG++Y +
Sbjct: 12 SSLKR-KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD 70
Query: 82 KQRHWLEPNKSIFKQ-MKTHPPYTMCFRVKFYPHEPLK-IKEELTRYLLYLQIKRDIFHG 139
WL+ +K + + P T F KFYP + + +E+T++L +LQ+K+ I
Sbjct: 71 TVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 140 RLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKN--- 196
++ C + L + VQA+ GDYDP H ++++ E+ PK+ L + E+ +
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 197 ----ELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKR 252
E RG++ AE L A LE YGV+ ++ GT LG A G ++ R
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENR 249
Query: 253 IH---LIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFY- 308
+ W ++ + + K F + K K + F++S K + + + N +
Sbjct: 250 LTPKISFPWNEIRNISYSDKEFTIKPLDK-KIDVFKFNSSKLRVNKLILQLCIGNHDLFM 308
Query: 309 --KYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSS 366
+ A S +++ + + K + ++A+E + + +R E+ R + +
Sbjct: 309 RRRKADSLEVQQMKAQAREEKARKQMERQRLARE-KQMREEAERTRDELERRLLQMKEEA 367
Query: 367 HSLNKQLIINMEPLQPLLPSPSEQEEELPL 396
N+ L+ + E L EEE L
Sbjct: 368 TMANEALMRSEETADLLAEKAQITEEEAKL 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,729,578
Number of Sequences: 37866
Number of extensions: 1238300
Number of successful extensions: 4775
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 4461
Number of HSP's gapped (non-prelim): 272
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.