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Search of human proteins with 116812628
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
(604 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 1200 0.0
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 233 5e-61
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 224 2e-58
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 222 7e-58
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 210 3e-54
gi|31982906 cingulin-like 1 [Homo sapiens] 80 5e-15
gi|71061468 centromere protein E [Homo sapiens] 78 2e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 77 3e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 77 5e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 77 5e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 77 5e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 77 5e-14
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 74 4e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 71 3e-12
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 71 3e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 69 1e-11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 69 1e-11
gi|4504063 golgin 97 [Homo sapiens] 69 1e-11
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 69 1e-11
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 69 1e-11
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 69 1e-11
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 69 2e-11
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 69 2e-11
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 69 2e-11
gi|118498368 kinectin 1 isoform c [Homo sapiens] 68 2e-11
gi|42794779 myosin 18A isoform b [Homo sapiens] 68 3e-11
gi|28416946 myosin 18A isoform a [Homo sapiens] 68 3e-11
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 68 3e-11
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 68 3e-11
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 67 4e-11
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 1200 bits (3104), Expect = 0.0
Identities = 604/604 (100%), Positives = 604/604 (100%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC
Sbjct: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV
Sbjct: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ
Sbjct: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS 240
FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS
Sbjct: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS 240
Query: 241 RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI 300
RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI
Sbjct: 241 RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI 300
Query: 301 GECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHN 360
GECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHN
Sbjct: 301 GECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHN 360
Query: 361 SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYK 420
SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYK
Sbjct: 361 SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYK 420
Query: 421 AVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKS 480
AVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKS
Sbjct: 421 AVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKS 480
Query: 481 TWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSD 540
TWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSD
Sbjct: 481 TWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSD 540
Query: 541 DDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
DDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ
Sbjct: 541 DDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
Query: 601 NRHI 604
NRHI
Sbjct: 601 NRHI 604
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 233 bits (593), Expect = 5e-61
Identities = 197/709 (27%), Positives = 338/709 (47%), Gaps = 123/709 (17%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
Query: 181 FQKQAQSYQTQLNGKKQCLED----SSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Query: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
Query: 297 LLKIGECQNA-----------------------------------------QGNKTRLES 315
+K Q+A Q T LE
Sbjct: 296 KVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
Query: 316 SYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMR 367
S L S+ +E K +EL + ++ E+ K++ Q+ Q E+ ++S E M+
Sbjct: 356 S-LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 414
Query: 368 NEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENT 427
EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E + K + ++++ EN
Sbjct: 415 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
Query: 428 HLKGMMGDLDPG--EYMSMDFTNREQSRHTSINKLQYENERLRNDL----AKLHV----- 476
HL M+ L+ G E + + +++ ++NKL EN++L+ DL ++L +
Sbjct: 475 HLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMC 534
Query: 477 -----------NGKSTWTNQNTYEETGRYAYQSQIKVEQNEERL-------SHDCEPNRS 518
+ ++T ++ T IK E + L S P
Sbjct: 535 KKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSR 594
Query: 519 TMPPLPP--------------------------STFQA--KEMTSPLVSDDDVFPLSPPD 550
+ PL P T +A + S ++D + F S
Sbjct: 595 VLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSL 654
Query: 551 MSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLK 599
P A FL EEE R+ + + L+ HI+EL+R +E T+ +++ LK
Sbjct: 655 PVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 224 bits (570), Expect = 2e-58
Identities = 150/459 (32%), Positives = 258/459 (56%), Gaps = 30/459 (6%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
Query: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Query: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
Query: 297 LLKIGECQNAQGNKTRLESSYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKI 348
+K Q+A +E+ L S+ +E K +EL + ++ E+ K+
Sbjct: 296 KVKATNTQHA------VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
Query: 349 RSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKM 408
+ Q+ Q E+ ++S E M+ EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E
Sbjct: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
Query: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFT 447
+ K + ++++ EN HL M+ L+ G + FT
Sbjct: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHERWGFT 448
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 222 bits (566), Expect = 7e-58
Identities = 156/497 (31%), Positives = 271/497 (54%), Gaps = 42/497 (8%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
Query: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Query: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
Query: 297 LLKIGECQNAQGNKTRLESSYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKI 348
+K Q+A +E+ L S+ +E K +EL + ++ E+ K+
Sbjct: 296 KVKATNTQHA------VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
Query: 349 RSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKM 408
+ Q+ Q E+ ++S E M+ EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E
Sbjct: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
Query: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEY-----------MSMDFTNREQSR-HTS 456
+ K + ++++ EN HL M+ L+ G + ++ F E+ R H
Sbjct: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
Query: 457 INKLQYENERLRNDLAK 473
+ +L E L+ + K
Sbjct: 470 LERLDAHIEELKRESEK 486
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 210 bits (534), Expect = 3e-54
Identities = 160/538 (29%), Positives = 273/538 (50%), Gaps = 78/538 (14%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
Query: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Query: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
Query: 297 LLKIGECQNA-----------------------------------------QGNKTRLES 315
+K Q+A Q T LE
Sbjct: 296 KVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
Query: 316 SYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMR 367
S L S+ +E K +EL + ++ E+ K++ Q+ Q E+ ++S E M+
Sbjct: 356 S-LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 414
Query: 368 NEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENT 427
EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E + K + ++++ EN
Sbjct: 415 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
Query: 428 HLKGMMGDLDPGEY-----------MSMDFTNREQSR-HTSINKLQYENERLRNDLAK 473
HL M+ L+ G + ++ F E+ R H + +L E L+ + K
Sbjct: 475 HLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.1 bits (196), Expect = 5e-15
Identities = 126/653 (19%), Positives = 260/653 (39%), Gaps = 93/653 (14%)
Query: 17 ELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQ--ELANAQTCLDQKGQEV-GLLRQ 73
E+ EL Q+ + V N++ E + R +LR Q E + L Q+ +E G LR+
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 74 KLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIP 133
L+ L + + Q ++ +++ L+ Q S++ + + + + ++ +EL K+++
Sbjct: 682 NLEELFQVKMEREQ-HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 134 FELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLN 193
L ++ + R + RE L A + L E+ + ++ + Q +
Sbjct: 741 DLLIAKEEQEDLLRKRERE--------------LTALKGALKEEVSSHDQEMDKLKEQYD 786
Query: 194 GKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQ 253
+ Q L +S E + + +E+D+ E + E KLQ +++L +
Sbjct: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE---ENEKLQGRSEELER 843
Query: 254 ELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI--------GECQN 305
+ QRQ + ++ ++ K L+ + +R +E + +E + E +
Sbjct: 844 RVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEA 903
Query: 306 AQGN---KTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK--------------- 347
AQGN T+ + +KE + ++L + + N L K
Sbjct: 904 AQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA 963
Query: 348 -------IRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKM 400
+++QL + +E + E M+ ++ + T E + +T + + L+E++L+
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRD 1023
Query: 401 ELEIKEKMLAKQKVSDMKYKAVRTE---NTHLKGMMGDL-----DPGEYMSMDFTNREQS 452
+++ L K+++ + K + E +HLK L D + M+ E+
Sbjct: 1024 YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL---EEE 1080
Query: 453 RHTS------INKLQYENERLRNDLA------------KLHVNGKSTWTNQNTYEETGRY 494
R+ S I++ + + E+LRN+L K+ + ++ G Y
Sbjct: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 495 AYQSQIKVEQNEER---LSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDM 551
+ V Q E R L E L S + + LV D LS D
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
Query: 552 SFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQNRHI 604
SL + + E+ +E+++L ++ +LQR E ++ N H+
Sbjct: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLESSK-KKLQRELE------EQMDMNEHL 1246
Score = 57.8 bits (138), Expect = 3e-08
Identities = 72/345 (20%), Positives = 153/345 (44%), Gaps = 32/345 (9%)
Query: 166 SLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEF 225
S D+ K +S K Q+ L G+++ + ++ E + I N E
Sbjct: 514 SPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQIL-------YNYLKEG 566
Query: 226 IIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRI 285
+ + ++ L K+Q + + + C + SEVK L+ + L
Sbjct: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNST----SEVKDLLEQKSKLT-- 620
Query: 286 IEMERLQLHREL-LKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKE 344
+E +L R+L L++ QN + + R+ ++ + K++E ++ Q E E
Sbjct: 621 --IEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGE 678
Query: 345 LNKIRSQLQQVE---EYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKME 401
L K +L QV+ E H +E +++++S++ +EL + + +K AL+E+ L+ +
Sbjct: 679 LRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS--EDREKGALIEELLQAK 736
Query: 402 LEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQ 461
++++ ++AK++ D+ K R E T LKG + + + ++ +Q +
Sbjct: 737 QDLQDLLIAKEEQEDLLRKRER-ELTALKGALKE---------EVSSHDQEMDKLKEQYD 786
Query: 462 YENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNE 506
E + LR + + N + + NT E+ + + ++K+ Q E
Sbjct: 787 AELQALRESVEEATKNVEVLASRSNTSEQ-DQAGTEMRVKLLQEE 830
Score = 34.3 bits (77), Expect = 0.34
Identities = 46/268 (17%), Positives = 114/268 (42%), Gaps = 20/268 (7%)
Query: 28 MVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQ----EVGLLRQKLDSLEKCNL 83
++ + D++R T+ L +Q L + + L+ K L++Q D + + +
Sbjct: 1016 LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 84 AMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKL 143
+ + L + S+ E+LR +++ Q + R++L K + + +L ++
Sbjct: 1076 ELEEERNNS-DLLSERISRSREQMEQLR-NELLQERAARQDLECDKISLERQNKDLKSRI 1133
Query: 144 EEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSS 203
R K+ ++ Q + + +L SE+ ++ Q + + + K+ ++
Sbjct: 1134 IHLEGSYRS-SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD 1192
Query: 204 SEIPRLICDPDPNCEINERDEFI---IEKLKSAVNEIALSRNKLQDENQKLLQELKMYQR 260
+ D +++ R + + +E+ + ++ + S+ KLQ E ++ + + Q
Sbjct: 1193 EHLSLT----DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
Query: 261 QCQAMEAGL------SEVKSELQSRDDL 282
Q +M+ L S+V ++ DDL
Sbjct: 1249 QLNSMKKDLRLKKLPSKVLDDMDDDDDL 1276
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 78.2 bits (191), Expect = 2e-14
Identities = 124/599 (20%), Positives = 247/599 (41%), Gaps = 57/599 (9%)
Query: 17 ELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLD 76
E E M Q + +S + ++ + AL+T L + QEL + ++ E+ L+++L+
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 77 SLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFEL 136
N + LQ+++ + + +T ++ L ++K + +L L+E + E
Sbjct: 898 -----------NRDSTLQTVEREKTLITEKLQQT-LEEVKTLTQEKDDLKQLQESLQIER 945
Query: 137 SNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKK 196
L + + + D QE L + L SL Q E N + + ++ +
Sbjct: 946 DQLKSDIHD--TVNMNIDTQEQL-RNALESLKQHQ----ETINTLKSKISEEVSRNLHME 998
Query: 197 QCLEDSSSEIPRLICDPDPNCEINERD-EFIIEKLKSAVNEIALSRNKLQDENQKLLQEL 255
+ ++ E + + D ++ ++ + + +K NEI + K+ L+QE
Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD--NEIIEQQRKIFS----LIQEK 1052
Query: 256 KMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLK-----IGECQNAQGNK 310
Q+ +++ A ++K++L+ ++ I E L+L + LK + + +N K
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMT-IENQEELRLLGDELKKQQEIVAQEKNHAIKK 1111
Query: 311 TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEI 370
S + E E K+KE +Q++ + QL V+E SE ++ NEI
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEKSQQLQEK----------QQQLLNVQE-EMSEMQKKINEI 1160
Query: 371 SDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLK 430
+L EL KE+T+ + + L ++L E + + ++KV K+ TE HL+
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
G + +++ T + I + + + D + V+ K+ E
Sbjct: 1221 GYIREIEA--------TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1272
Query: 491 TGRYAYQSQIKVEQNEERL---SHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLS 547
Q +I V E+ L + + TM L T Q+ S ++ ++ L
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
Query: 548 PPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKY--SKLKQNRHI 604
+ F S L +E K +++ L D+L+ H TL K S+ KQ + +
Sbjct: 1333 LNE-KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1390
Score = 72.8 bits (177), Expect = 9e-13
Identities = 117/529 (22%), Positives = 216/529 (40%), Gaps = 87/529 (16%)
Query: 87 QNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEF 146
+N E +L SL+A + L ++E+LR KEE+ +L N L+EF
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTE---------------KEEMELKLKEKND-LDEF 537
Query: 147 RAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEI 206
A R+ K + + H IS L + Q + +L+ K + L + +I
Sbjct: 538 EALERKTKKDQEMQLIHEISN------LKNLVKHAEVYNQDLENELSSKVELLREKEDQI 591
Query: 207 PRL--ICDPDPNCEINERDEFIIEKLKSA---------VNEIALSRNK----LQDENQKL 251
+L D I + +E ++ +AL + L+ EN +L
Sbjct: 592 KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLEL 651
Query: 252 LQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKT 311
+++K + ME + +S+L+++ + +E E E+ K+ + + K
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 312 RLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK-IRSQLQQVEEYHN--SEQERMRN 368
L + L E KI +L Q + N E E N+ +R ++ + E + SE ER+R
Sbjct: 712 LLCNLEL------EGKITDL----QKELNKEVEENEALREEVILLSELKSLPSEVERLRK 761
Query: 369 EISDLTEELH----QKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRT 424
EI D +EELH +K+ + V K + ++ L+ + K+ + Q YK+
Sbjct: 762 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS----NYKSTDQ 817
Query: 425 ENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTN 484
E + K + D + M ++ R +++K E ++ + L L + ++
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK---EAQKFDSSLGALKT--ELSYKT 872
Query: 485 QNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVF 544
Q E+T R + ++EQ +E+L NR ST Q E L+++
Sbjct: 873 QELQEKT-REVQERLNEMEQLKEQLE-----NRD-------STLQTVEREKTLITE---- 915
Query: 545 PLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLN 593
+L L +E+ K+L++ L D+L+ T+N
Sbjct: 916 -------KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVN 957
Score = 71.2 bits (173), Expect = 3e-12
Identities = 98/440 (22%), Positives = 192/440 (43%), Gaps = 65/440 (14%)
Query: 17 ELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLD 76
E QE ++++ +VS K +L ++L N+ L +K QE+ +L
Sbjct: 1785 EQQETIDKLRGIVSEKT-----------DKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 77 SLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLR-------------LHQMKQNKVPRK 123
+L+K ++ TQ +++ LK Q + KL L +MK R
Sbjct: 1834 TLKK-DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892
Query: 124 ELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQ----EILYQTHLISLDAQQKLLSEKCN 179
L ++E + E L + L+E +A+ E ++ +L + H ++D ++ +SEK
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
Query: 180 QF---QKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPD-PNCEINERDEFIIEKLKSAVN 235
Q QK + +L K Q L+ ++ R+ D + + +INE +E+LK
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE-----MEQLKKQFE 2007
Query: 236 EIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHR 295
LS ++ +N +L ++L L E++ + RD+L RI E +++ +
Sbjct: 2008 AQNLSMQSVRMDNFQLTKKL----------HESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Query: 296 ELLKIGE--CQNAQGNKTRLESSYLP--------SIKEPERKIKELFSVMQDQPNHEKEL 345
+ + E ++ Q ++ + E L S++E +IKEL + +H + L
Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
Query: 346 NKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEI-TIATVTKKAAL----LEKQLKM 400
N++ L++ E+ R++ +S L K I + T ++ ++ + K+LK
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLS--LPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY 2175
Query: 401 ELEIKEKMLAKQKVSDMKYK 420
L K+ +Q S K++
Sbjct: 2176 VLSYVTKIKEEQHESINKFE 2195
Score = 60.5 bits (145), Expect = 4e-09
Identities = 131/666 (19%), Positives = 261/666 (39%), Gaps = 101/666 (15%)
Query: 6 HNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKG 65
H T + E Q+ M ID KK D E K T D++D E+ Q +
Sbjct: 996 HMEENTGETKDEFQQKMVGID-----KKQDLEAKNTQTLTA-DVKDNEIIEQQRKIFSLI 1049
Query: 66 QEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRL---HQMKQNKVPR 122
QE L+Q L+S+ E LK N E+LRL KQ ++
Sbjct: 1050 QEKNELQQMLESV-------IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVA 1102
Query: 123 KELPH-LKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQF 181
+E H +K+E ELS +L E K +E +Q Q L+++ + + +K N+
Sbjct: 1103 QEKNHAIKKE--GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 182 QK----------QAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLK 231
+ + +T+ Q L ++ E+ + + E+ + E + L+
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 232 SAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRI---IEM 288
+ EI + + ++E + LK +Q + +SE +++ + DL + ++
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 289 ERLQLHRE------LLKIGECQNAQGN----------------------KTRLESSYLPS 320
E LH E + ++ E Q + RL + S
Sbjct: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES 1340
Query: 321 IKEPE---------RKIKELFSVMQDQ-PNHEKE-LNKIR-SQLQQVEEYHNSEQERMRN 368
+E + + IKE V DQ H +E L KI+ SQ +Q + + E++
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400
Query: 369 EISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAV-RTENT 427
+I E+ K+ + + + L K+L+ E + K +AK+K + + V ++E+
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ-ESHDEMKSVAKEKDDLQRLQEVLQSESD 1459
Query: 428 HLKGMMGD-----LDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLH-----VN 477
LK + + L+ E + + ++ T IN+L+ +++ + +N
Sbjct: 1460 QLKENIKEIVAKHLETEEELKVAHCCLKEQEET-INELRVNLSEKETEISTIQKQLEAIN 1518
Query: 478 GKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPL 537
K Q YE+ ++ + +V++ L E ++ L + E+T+ L
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 538 VSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSK 597
+ + +++E++ K +++ L D+L+ +T+ + K +
Sbjct: 1579 QESQEEIQI----------------MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKE 1622
Query: 598 LKQNRH 603
++ +
Sbjct: 1623 SQEKEY 1628
Score = 50.4 bits (119), Expect = 5e-06
Identities = 98/495 (19%), Positives = 209/495 (42%), Gaps = 78/495 (15%)
Query: 19 QELMEQIDIM--VSNKKMDWERKMRALETRLDL--------------RDQELANAQTCLD 62
+ L E D M V+ +K D +R L++ D ++EL A CL
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 63 QKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPR 122
++ + + LR L E + + E L+ + ++ E+ + Q+ + +
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 123 KELPHLKEEIPFE---LSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCN 179
EL KE + L ++ K+ E + +E ++EI Q ++ EK
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQE-SQEEI------------QIMIKEK-- 1592
Query: 180 QFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLK-SAVNE-- 236
++ + Q L ++ L++++ EI ++ E E + LK +AVNE
Sbjct: 1593 ---EEMKRVQEALQIERDQLKENTKEIV---------AKMKESQEKEYQFLKMTAVNETQ 1640
Query: 237 ---IALSRNKLQDENQKL-LQELKMYQ-RQCQAMEAGLSEVKSELQSRDDLLRIIEMERL 291
+ K Q E QKL L+ ++ R Q + L E++S + RDD LR +E E L
Sbjct: 1641 EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD-LRSVE-ETL 1698
Query: 292 QLHRELLKIGECQNAQGNKTRLESSYL--PSIKEPERKIKELFSVMQDQPNHEKELNKIR 349
++ R+ LK + + + E + +KE + I +L ++ ++ N E++ ++
Sbjct: 1699 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN---EISNMQ 1755
Query: 350 SQLQQVEEYHNSEQERMRNEISDLTEELHQKEITI-------ATVTKKAALLEKQLKMEL 402
L+ + ++ +++ E+ L +++ TI + T K + ++K L+
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN 1815
Query: 403 EIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQY 462
++ + + K ++ + ++ + + + +++ + + + +++KL+
Sbjct: 1816 AKLQEKIQELKANEHQLITLKKDVNETQKKVSEME-------QLKKQIKDQSLTLSKLEI 1868
Query: 463 ENERLRNDLAKLHVN 477
EN L KLH N
Sbjct: 1869 ENLNLAQ---KLHEN 1880
Score = 37.4 bits (85), Expect = 0.040
Identities = 61/379 (16%), Positives = 149/379 (39%), Gaps = 43/379 (11%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQ----ELANAQTCLDQK--GQEV 68
E+E + + ++SN+K + L TR D+ + N + C +
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRI 2307
Query: 69 GLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHL 128
+ + E+ + +++ +E L+SLK + KL N++ L+ +V +
Sbjct: 2308 IAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNK 2367
Query: 129 KEEIPFELSNL-NQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQS 187
+ + L +K+ E E + + ++ +I + + ++ ++ +
Sbjct: 2368 NPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL------ 2421
Query: 188 YQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDE 247
Q +++ +CLE + I L ++ + K + ++ + K+ E
Sbjct: 2422 -QAKVHESNKCLEKTKETIQVL----------QDKVALGAKPYKEEIEDLKMKLVKIDLE 2470
Query: 248 NQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRII--EMERLQLHRELLKIGECQN 305
K +E E +S K+ ++ + +++R++ + R Q ++ I E +
Sbjct: 2471 KMKNAKE----------FEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD 2520
Query: 306 AQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHN---SE 362
Q + L I + + + + + EKE++K++ Q +Q+ + N S
Sbjct: 2521 PQPSNKPLTCGGGSGIVQNTKAL----ILKSEHIRLEKEISKLKQQNEQLIKQKNELLSN 2576
Query: 363 QERMRNEISDLTEELHQKE 381
+ + NE+ E ++E
Sbjct: 2577 NQHLSNEVKTWKERTLKRE 2595
Score = 31.6 bits (70), Expect = 2.2
Identities = 85/462 (18%), Positives = 191/462 (41%), Gaps = 83/462 (17%)
Query: 17 ELQELMEQIDIMVSNKKM-DWERKMRALETR-LDLRDQELANAQTC--LDQKGQEVGLLR 72
ELQ L + D+ +S+KK+ + E+ + E + L ++ + N Q L + +E+ ++
Sbjct: 1979 ELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVA 2038
Query: 73 QKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKEL-----PH 127
++ D L + ++ + + +L+ ++ N HQ+K P K L H
Sbjct: 2039 KERDELRRIKESLKMERDQFIATLREMIARDRQN------HQVK----PEKRLLSDGQQH 2088
Query: 128 LKEEIPFELSNLNQKLEEFRAKSREWD---------KQEILYQTHL-------ISLDAQQ 171
L E + + S + + L+ + ++ ++EI +Q L +SL Q
Sbjct: 2089 LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQ 2148
Query: 172 -----KLLS--EKCN-QFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERD 223
KL + ++C+ +F + + + L+ + E+ I + + D E+ ++
Sbjct: 2149 TKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF--EMDFIDEVEKQK 2206
Query: 224 EFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQ----SR 279
E +I K++ + + +L+D +L + + E+ +K+E Q +R
Sbjct: 2207 ELLI-KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNR 2265
Query: 280 DDLLRIIE--------MERLQ--LHRELLKIGECQNAQGNK--------TRLESSYLPSI 321
++ + +E +E+L+ + +E +I + N N+ T E
Sbjct: 2266 KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
Query: 322 KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMR------------NE 369
KE E+ +K S+ + K +++ L + + + Q+ +
Sbjct: 2326 KEWEQDLK---SLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 370 ISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAK 411
I +L LH+ + + K ++K+L++ +I K+ AK
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 77.4 bits (189), Expect = 3e-14
Identities = 106/516 (20%), Positives = 231/516 (44%), Gaps = 53/516 (10%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALET--------RLDLRDQELANAQTCLDQKGQ 66
E E+ E++ + V K++ E ++ +ET +L L++Q A + C + +
Sbjct: 844 EEEMMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 67 EVGLLRQKLDSLEKCN--LAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKE 124
L +K + E C+ A + E + Q L+A+ K+ N ++L Q+++ + R++
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE-EQLEEEESARQK 961
Query: 125 LPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQ 184
L E++ E AK ++ ++++I+ + L ++KLL ++ +F
Sbjct: 962 LQ--LEKVTTE------------AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 185 AQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKL 244
T+ K + L ++ +I D + E+ +EK + + + +
Sbjct: 1008 L----TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 245 QDENQKLLQELKMY-QRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGEC 303
E Q + ELKM ++ + ++A L+ V+ E ++ L+ I Q+ EL + E
Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS-ELQEDLES 1122
Query: 304 QNAQGNKTRLES----SYLPSIK-EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEY 358
+ A NK + L ++K E E + + + + E+E+N ++ L++ +
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 359 HNSEQERMRNE----ISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKV 414
H ++ + MR + + +L E+L Q + A + K LE + + EL + K+L + K
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE-RGELANEVKVLLQGK- 1240
Query: 415 SDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKL 474
D ++K + E L+ + + GE + + ++ + KLQ E + + L++
Sbjct: 1241 GDSEHKRKKVE-AQLQELQVKFNEGERVRTELADK-------VTKLQVELDNVTGLLSQ- 1291
Query: 475 HVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLS 510
+ KS+ ++ + ++ E+N ++LS
Sbjct: 1292 -SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Score = 59.3 bits (142), Expect = 1e-08
Identities = 89/450 (19%), Positives = 197/450 (43%), Gaps = 52/450 (11%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALE-TRLDLRDQ------ELANAQTCLDQKGQE 67
EA + +L E++ ++ + E+ R LE DL DQ ++A + L +K +E
Sbjct: 1026 EAMITDLEERLR-REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084
Query: 68 V--GLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPR--- 122
+ L R + ++ +K N+A+ + ++ L++Q S+L + E R + K K R
Sbjct: 1085 LQAALARVEEEAAQK-NMALKK-----IRELESQISELQEDLESERASRNKAEKQKRDLG 1138
Query: 123 KELPHLKEEIPFELSNL-------NQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLS 175
+EL LK E+ L + +++ +E + +++ ++ + + +
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAV 1198
Query: 176 EKCNQFQKQAQSYQTQLNGKKQCLEDS----SSEIPRLICDPDPNCEINERDEFIIEKLK 231
E+ + +Q + + L KQ LE+ ++E+ L+ + ++ E +++L+
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 232 SAVNEIALSRNKLQDENQKLLQEL-------KMYQRQCQAMEAGLSEVKSELQSRDDLLR 284
NE R +L D+ KL EL + + S ++S+LQ +LL+
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 285 IIEMERLQLHRELLKIGECQN-----------AQGNKTRLESSYLPSIKEPERKIKELFS 333
++L L +L ++ + +N A+ N + ++ + + ++K+++
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 334 VMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAAL 393
++ +++L K L Q E + +++ + L +EL + + + A
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 394 LEKQLKMELEIKEKMLAKQKVSDMKYKAVR 423
LEK+ K +++LA++K KY R
Sbjct: 1439 LEKKQKK----FDQLLAEEKTISAKYAEER 1464
Score = 53.1 bits (126), Expect = 7e-07
Identities = 81/442 (18%), Positives = 185/442 (41%), Gaps = 62/442 (14%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIM------VSNKKMDWERKMRALETRLDLRDQEL 54
ME +A E+++LM D + + K E+++ ++T+L+ + EL
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 55 -----------ANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFS-- 101
N Q Q +++ ++ + +K + + E +L+ + Q S
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 102 -----KLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQ 156
KL + + L H NK + + L++ + ++ + ++L++ RA E Q
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTRASREEILAQ 1667
Query: 157 EILYQTHLISLDAQQKLLSEK---CNQFQKQAQSYQTQL-------NGKKQCLEDSSSEI 206
+ L S++A+ L E+ + ++QAQ + +L +GK + +
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 207 PRLICDPDPNCEINERD-EFIIEKLKSA---VNEIALSRNKLQDENQKLLQELKMYQRQC 262
I + E + + E I ++LK A +++I N + QK + +RQ
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 263 QAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIK 322
+ ++ L E++ ++S+ I +E KI + + N+T+ + ++
Sbjct: 1788 KELKVKLQEMEGTVKSKYKA-SITALEA--------KIAQLEEQLDNETKERQAACKQVR 1838
Query: 323 EPERKIKELFSVMQDQPNHEKE-----------LNKIRSQLQQVEE---YHNSEQERMRN 368
E+K+K++ + D+ + ++ L +++ QL++ EE N+ + +++
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Query: 369 EISDLTEELHQKEITIATVTKK 390
E+ D TE ++++ K
Sbjct: 1899 ELEDATETADAMNREVSSLKNK 1920
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/431 (18%), Positives = 182/431 (42%), Gaps = 52/431 (12%)
Query: 8 TMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQE 67
T S E++LQ+ E + + +K+ K++ +E + ++L + ++
Sbjct: 1300 TKDFSALESQLQDTQELLQ-EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358
Query: 68 VGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKE-LP 126
+ L ++ ++K ++ G L++ + KL + E L Q + KV + L
Sbjct: 1359 IATLHAQVADMKK----KMEDSVGCLETAEEVKRKLQKDLEGLS--QRHEEKVAAYDKLE 1412
Query: 127 HLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQ 186
K + EL +L L+ R + +K++ + L +E+ ++ + +A+
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472
Query: 187 SYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQD 246
+T+ + LE++ + L +N++ +E L S+ +++ S ++L+
Sbjct: 1473 EKETKALSLARALEEAMEQKAELE-------RLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 247 ENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNA 306
+ L Q+++ E+K++L+ +D L+ E +L+L N
Sbjct: 1526 SKRALEQQVE--------------EMKTQLEELEDELQATEDAKLRLE---------VNL 1562
Query: 307 QGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERM 366
Q K + E ++ E K K+L +++ E EL R Q + ++++
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREM---EAELEDERKQRSMAV----AARKKL 1615
Query: 367 RNEISDLTEELHQKEITIATVTKKAALLEKQLK---MELE----IKEKMLAKQKVSDMKY 419
++ DL + K+ L+ Q+K EL+ +E++LA+ K ++ K
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675
Query: 420 KAVRTENTHLK 430
K++ E L+
Sbjct: 1676 KSMEAEMIQLQ 1686
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 77.0 bits (188), Expect = 5e-14
Identities = 103/506 (20%), Positives = 226/506 (44%), Gaps = 77/506 (15%)
Query: 18 LQELMEQIDIMVSNKKM---DWERKMRALETRL-----------DLRDQELANAQTCLDQ 63
LQ+ ++ + + + N++ + E+K R + L D RD+ A A+ ++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EK 1481
Query: 64 KGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL--RLHQMKQNKVP 121
+ + + L R ++LE + E + LKA+ L ++ + + +H+++++K
Sbjct: 1482 ETKALSLARALEEALEA-----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-- 1534
Query: 122 RKELPHLKEEIPFELSNLNQKLEEFR-AKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
+ L EE+ +L L +L+ AK R + L L A+ + EK Q
Sbjct: 1535 -RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP-----DPNCEINERDEFI--IEKLKSA 233
Q+Q Y+T+L +++ +++ +L D + I R+E I + KL++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 234 VNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQL 293
+ + + ++ K +++ +++EA L +++ +L + + + ++E+ +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 294 HRELLKIGECQNA-QGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL 352
EL +NA Q K RLE+ I + E +++E +Q N E +++R
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEA----RIAQLEEELEE------EQGNMEAMSDRVRKAT 1763
Query: 353 QQVEEYHN-------------SEQERMRNEISDLTEELHQKE--------ITIATVTKKA 391
QQ E+ N S ++++ + +L +LH+ E TIA + K
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 392 ALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQ 451
A LE+Q +E E +EK A K+++ ++ LK ++ ++ M+ + + +
Sbjct: 1824 AQLEEQ--VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 452 SRHTSINKLQYENERLRNDLAKLHVN 477
+ + +L+ + E + +++ N
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINAN 1899
Score = 67.0 bits (162), Expect = 5e-11
Identities = 99/506 (19%), Positives = 220/506 (43%), Gaps = 48/506 (9%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSL 96
E +M+A E L + A+ L + Q+ L ++ + L++ A T+ Y + + +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-AEAEEM 909
Query: 97 KAQFSKLTNNFEKLRLHQMK----QNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSRE 152
+ + + E++ LH+M+ + + ++L ++++ ++ +L ++LEE A ++
Sbjct: 910 RVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+++ + + L+ + ++ ++ N+ K+ + + +++ L + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-- 1026
Query: 213 PDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEV 272
++ + E +I +L+ + + SR +L+ +KL + + Q ++A ++E+
Sbjct: 1027 -----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 273 K-------SELQSR----DD--------LLRIIEMER--LQLHRELLKIGECQNAQGNKT 311
K ELQ+ DD L +I E+E L +L +N +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 312 RLESSYLPSIK-EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNE- 369
R L ++K E E + + + + E+E+ ++ L + H ++ + MR +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 370 ---ISDLTEELHQKEITIATVTKKAALLEKQ-LKMELEIKEKMLAKQKVSDMKYKAVRTE 425
+ +LTE+L Q + A + K LEK+ + E++ AKQ+V + K K + +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQ 1260
Query: 426 NTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENE----RLRNDLAKLHVNGKST 481
L+ D + D ++ Q+ S+ + E E +L D+A L + T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 482 WTNQNTYEETGRYAYQSQIKVEQNEE 507
Q +E R K+ Q EE
Sbjct: 1321 ---QELLQEETRQKLNVSTKLRQLEE 1343
Score = 61.6 bits (148), Expect = 2e-09
Identities = 115/600 (19%), Positives = 239/600 (39%), Gaps = 40/600 (6%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
EA++QE+ ++ V E+ RA + LD Q L L + + +G +Q+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPF 134
++ +K A Q + + + ++L + KL+ ++++ E ++
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAK 1308
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG 194
++++L+ +L++ + +E +Q++ T L L+ ++ L ++ ++ + Q+ + ++
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 195 KKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQE 254
L DS ++ + E +R + IE L E A + +KL+ +L QE
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 255 LKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERLQLHRELLKIGECQNAQGNK 310
L +S ++ + + D LL I + R + E + +
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 311 TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEI 370
R L + +E ER K L + M+D + + ++ K +L++ + ++ E M+ ++
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 371 SDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLK 430
+L +EL E K+ LE+ + L Q D++ R E K
Sbjct: 1549 EELEDELQATE---------------DAKLRLEVNMQALKGQFERDLQ---ARDEQNEEK 1590
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
EY + R+Q + K ++L DL L + S + +
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAK-----KKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 491 TGRYAYQSQIKVEQNE---ERLSHD-----CEPNRSTMPPLPPSTFQAKEMTSPLVSDDD 542
R Q+Q+K Q E R S D + N L Q +E +
Sbjct: 1646 QLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 543 VFPLSPPDMS--FPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
L +++ +SL+ ++ L +E++R + L ++E Q + E ++ K Q
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/382 (17%), Positives = 159/382 (41%), Gaps = 46/382 (12%)
Query: 243 KLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGE 302
K ++ QK ELK +++ + + ++ +LQ+ +L E R++L + ++ E
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 303 C---------------QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK 347
Q Q + ++ L ++ E + + ++ E ++ K
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 348 IRSQLQQVEEYHN---SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQL-KMELE 403
+ ++ +++ +N E++ + ISDLT L ++E +TK E + ++E+
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPG-EYMSMDFTNREQSRHTSINKLQY 462
+K++ ++Q++ +K K + + + + DL + M +E+ ++ +L
Sbjct: 1043 LKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 463 ENERLRNDLAKL-HVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMP 521
E + N L K+ + G + ++ E ++ K E+ + L + E ++ +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERA-----ARNKAEKQKRDLGEELEALKTELE 1156
Query: 522 PLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKE--LEKLLNT 579
ST +E+ + + V + L+EE R+ E ++++
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKA----------------LDEETRSHEAQVQEMRQK 1200
Query: 580 HIDELQRHTEFTLNKYSKLKQN 601
H ++ TE L ++ + K N
Sbjct: 1201 HAQAVEELTE-QLEQFKRAKAN 1221
Score = 39.7 bits (91), Expect = 0.008
Identities = 67/334 (20%), Positives = 136/334 (40%), Gaps = 60/334 (17%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ EL++ D + + K + E+K ++LE L ++LA A+ Q E L ++
Sbjct: 1658 QRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK---ELPHLKEE 131
L S +L+ + + + L+A+ ++L E+ + + + RK + L E
Sbjct: 1717 LAS----SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 132 IPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKL------LSEKCNQFQKQA 185
+ E S QK E R + +K E+ + H + + K L K Q ++Q
Sbjct: 1773 LATERSTA-QKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 186 QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
+ + + L+ ++ ++ LQ
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEIL---------------------------------LQ 1857
Query: 246 DENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQN 305
E+++ + E Y+ Q + A + ++K +L+ ++ + I R +L REL + E
Sbjct: 1858 VEDERKMAE--QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 306 AQGN-----KTRL----ESSYLPSIKEPERKIKE 330
A G K++L E+S++PS + R++ E
Sbjct: 1916 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 77.0 bits (188), Expect = 5e-14
Identities = 103/506 (20%), Positives = 226/506 (44%), Gaps = 77/506 (15%)
Query: 18 LQELMEQIDIMVSNKKM---DWERKMRALETRL-----------DLRDQELANAQTCLDQ 63
LQ+ ++ + + + N++ + E+K R + L D RD+ A A+ ++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EK 1488
Query: 64 KGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL--RLHQMKQNKVP 121
+ + + L R ++LE + E + LKA+ L ++ + + +H+++++K
Sbjct: 1489 ETKALSLARALEEALEA-----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-- 1541
Query: 122 RKELPHLKEEIPFELSNLNQKLEEFR-AKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
+ L EE+ +L L +L+ AK R + L L A+ + EK Q
Sbjct: 1542 -RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP-----DPNCEINERDEFI--IEKLKSA 233
Q+Q Y+T+L +++ +++ +L D + I R+E I + KL++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 234 VNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQL 293
+ + + ++ K +++ +++EA L +++ +L + + + ++E+ +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 294 HRELLKIGECQNA-QGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL 352
EL +NA Q K RLE+ I + E +++E +Q N E +++R
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEA----RIAQLEEELEE------EQGNMEAMSDRVRKAT 1770
Query: 353 QQVEEYHN-------------SEQERMRNEISDLTEELHQKE--------ITIATVTKKA 391
QQ E+ N S ++++ + +L +LH+ E TIA + K
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 392 ALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQ 451
A LE+Q +E E +EK A K+++ ++ LK ++ ++ M+ + + +
Sbjct: 1831 AQLEEQ--VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 452 SRHTSINKLQYENERLRNDLAKLHVN 477
+ + +L+ + E + +++ N
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINAN 1906
Score = 67.0 bits (162), Expect = 5e-11
Identities = 99/506 (19%), Positives = 220/506 (43%), Gaps = 48/506 (9%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSL 96
E +M+A E L + A+ L + Q+ L ++ + L++ A T+ Y + + +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-AEAEEM 916
Query: 97 KAQFSKLTNNFEKLRLHQMK----QNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSRE 152
+ + + E++ LH+M+ + + ++L ++++ ++ +L ++LEE A ++
Sbjct: 917 RVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+++ + + L+ + ++ ++ N+ K+ + + +++ L + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-- 1033
Query: 213 PDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEV 272
++ + E +I +L+ + + SR +L+ +KL + + Q ++A ++E+
Sbjct: 1034 -----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 273 K-------SELQSR----DD--------LLRIIEMER--LQLHRELLKIGECQNAQGNKT 311
K ELQ+ DD L +I E+E L +L +N +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 312 RLESSYLPSIK-EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNE- 369
R L ++K E E + + + + E+E+ ++ L + H ++ + MR +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 370 ---ISDLTEELHQKEITIATVTKKAALLEKQ-LKMELEIKEKMLAKQKVSDMKYKAVRTE 425
+ +LTE+L Q + A + K LEK+ + E++ AKQ+V + K K + +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQ 1267
Query: 426 NTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENE----RLRNDLAKLHVNGKST 481
L+ D + D ++ Q+ S+ + E E +L D+A L + T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 482 WTNQNTYEETGRYAYQSQIKVEQNEE 507
Q +E R K+ Q EE
Sbjct: 1328 ---QELLQEETRQKLNVSTKLRQLEE 1350
Score = 61.6 bits (148), Expect = 2e-09
Identities = 115/600 (19%), Positives = 239/600 (39%), Gaps = 40/600 (6%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
EA++QE+ ++ V E+ RA + LD Q L L + + +G +Q+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPF 134
++ +K A Q + + + ++L + KL+ ++++ E ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAK 1315
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG 194
++++L+ +L++ + +E +Q++ T L L+ ++ L ++ ++ + Q+ + ++
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 195 KKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQE 254
L DS ++ + E +R + IE L E A + +KL+ +L QE
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 255 LKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERLQLHRELLKIGECQNAQGNK 310
L +S ++ + + D LL I + R + E + +
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 311 TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEI 370
R L + +E ER K L + M+D + + ++ K +L++ + ++ E M+ ++
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 371 SDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLK 430
+L +EL E K+ LE+ + L Q D++ R E K
Sbjct: 1556 EELEDELQATE---------------DAKLRLEVNMQALKGQFERDLQ---ARDEQNEEK 1597
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
EY + R+Q + K ++L DL L + S + +
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAK-----KKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 491 TGRYAYQSQIKVEQNE---ERLSHD-----CEPNRSTMPPLPPSTFQAKEMTSPLVSDDD 542
R Q+Q+K Q E R S D + N L Q +E +
Sbjct: 1653 QLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 543 VFPLSPPDMS--FPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
L +++ +SL+ ++ L +E++R + L ++E Q + E ++ K Q
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/382 (17%), Positives = 159/382 (41%), Gaps = 46/382 (12%)
Query: 243 KLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGE 302
K ++ QK ELK +++ + + ++ +LQ+ +L E R++L + ++ E
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 303 C---------------QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK 347
Q Q + ++ L ++ E + + ++ E ++ K
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 348 IRSQLQQVEEYHN---SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQL-KMELE 403
+ ++ +++ +N E++ + ISDLT L ++E +TK E + ++E+
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPG-EYMSMDFTNREQSRHTSINKLQY 462
+K++ ++Q++ +K K + + + + DL + M +E+ ++ +L
Sbjct: 1050 LKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 463 ENERLRNDLAKL-HVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMP 521
E + N L K+ + G + ++ E ++ K E+ + L + E ++ +
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERA-----ARNKAEKQKRDLGEELEALKTELE 1163
Query: 522 PLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKE--LEKLLNT 579
ST +E+ + + V + L+EE R+ E ++++
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKA----------------LDEETRSHEAQVQEMRQK 1207
Query: 580 HIDELQRHTEFTLNKYSKLKQN 601
H ++ TE L ++ + K N
Sbjct: 1208 HAQAVEELTE-QLEQFKRAKAN 1228
Score = 39.7 bits (91), Expect = 0.008
Identities = 67/334 (20%), Positives = 136/334 (40%), Gaps = 60/334 (17%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ EL++ D + + K + E+K ++LE L ++LA A+ Q E L ++
Sbjct: 1665 QRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK---ELPHLKEE 131
L S +L+ + + + L+A+ ++L E+ + + + RK + L E
Sbjct: 1724 LAS----SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 132 IPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKL------LSEKCNQFQKQA 185
+ E S QK E R + +K E+ + H + + K L K Q ++Q
Sbjct: 1780 LATERSTA-QKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 186 QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
+ + + L+ ++ ++ LQ
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEIL---------------------------------LQ 1864
Query: 246 DENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQN 305
E+++ + E Y+ Q + A + ++K +L+ ++ + I R +L REL + E
Sbjct: 1865 VEDERKMAE--QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 306 AQGN-----KTRL----ESSYLPSIKEPERKIKE 330
A G K++L E+S++PS + R++ E
Sbjct: 1923 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 77.0 bits (188), Expect = 5e-14
Identities = 103/506 (20%), Positives = 226/506 (44%), Gaps = 77/506 (15%)
Query: 18 LQELMEQIDIMVSNKKM---DWERKMRALETRL-----------DLRDQELANAQTCLDQ 63
LQ+ ++ + + + N++ + E+K R + L D RD+ A A+ ++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EK 1488
Query: 64 KGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL--RLHQMKQNKVP 121
+ + + L R ++LE + E + LKA+ L ++ + + +H+++++K
Sbjct: 1489 ETKALSLARALEEALEA-----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-- 1541
Query: 122 RKELPHLKEEIPFELSNLNQKLEEFR-AKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
+ L EE+ +L L +L+ AK R + L L A+ + EK Q
Sbjct: 1542 -RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP-----DPNCEINERDEFI--IEKLKSA 233
Q+Q Y+T+L +++ +++ +L D + I R+E I + KL++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 234 VNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQL 293
+ + + ++ K +++ +++EA L +++ +L + + + ++E+ +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 294 HRELLKIGECQNA-QGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL 352
EL +NA Q K RLE+ I + E +++E +Q N E +++R
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEA----RIAQLEEELEE------EQGNMEAMSDRVRKAT 1770
Query: 353 QQVEEYHN-------------SEQERMRNEISDLTEELHQKE--------ITIATVTKKA 391
QQ E+ N S ++++ + +L +LH+ E TIA + K
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 392 ALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQ 451
A LE+Q +E E +EK A K+++ ++ LK ++ ++ M+ + + +
Sbjct: 1831 AQLEEQ--VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 452 SRHTSINKLQYENERLRNDLAKLHVN 477
+ + +L+ + E + +++ N
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINAN 1906
Score = 67.0 bits (162), Expect = 5e-11
Identities = 99/506 (19%), Positives = 220/506 (43%), Gaps = 48/506 (9%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSL 96
E +M+A E L + A+ L + Q+ L ++ + L++ A T+ Y + + +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-AEAEEM 916
Query: 97 KAQFSKLTNNFEKLRLHQMK----QNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSRE 152
+ + + E++ LH+M+ + + ++L ++++ ++ +L ++LEE A ++
Sbjct: 917 RVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+++ + + L+ + ++ ++ N+ K+ + + +++ L + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-- 1033
Query: 213 PDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEV 272
++ + E +I +L+ + + SR +L+ +KL + + Q ++A ++E+
Sbjct: 1034 -----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 273 K-------SELQSR----DD--------LLRIIEMER--LQLHRELLKIGECQNAQGNKT 311
K ELQ+ DD L +I E+E L +L +N +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 312 RLESSYLPSIK-EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNE- 369
R L ++K E E + + + + E+E+ ++ L + H ++ + MR +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 370 ---ISDLTEELHQKEITIATVTKKAALLEKQ-LKMELEIKEKMLAKQKVSDMKYKAVRTE 425
+ +LTE+L Q + A + K LEK+ + E++ AKQ+V + K K + +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQ 1267
Query: 426 NTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENE----RLRNDLAKLHVNGKST 481
L+ D + D ++ Q+ S+ + E E +L D+A L + T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 482 WTNQNTYEETGRYAYQSQIKVEQNEE 507
Q +E R K+ Q EE
Sbjct: 1328 ---QELLQEETRQKLNVSTKLRQLEE 1350
Score = 61.6 bits (148), Expect = 2e-09
Identities = 115/600 (19%), Positives = 239/600 (39%), Gaps = 40/600 (6%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
EA++QE+ ++ V E+ RA + LD Q L L + + +G +Q+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPF 134
++ +K A Q + + + ++L + KL+ ++++ E ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAK 1315
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG 194
++++L+ +L++ + +E +Q++ T L L+ ++ L ++ ++ + Q+ + ++
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 195 KKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQE 254
L DS ++ + E +R + IE L E A + +KL+ +L QE
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 255 LKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERLQLHRELLKIGECQNAQGNK 310
L +S ++ + + D LL I + R + E + +
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 311 TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEI 370
R L + +E ER K L + M+D + + ++ K +L++ + ++ E M+ ++
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 371 SDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLK 430
+L +EL E K+ LE+ + L Q D++ R E K
Sbjct: 1556 EELEDELQATE---------------DAKLRLEVNMQALKGQFERDLQ---ARDEQNEEK 1597
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
EY + R+Q + K ++L DL L + S + +
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAK-----KKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 491 TGRYAYQSQIKVEQNE---ERLSHD-----CEPNRSTMPPLPPSTFQAKEMTSPLVSDDD 542
R Q+Q+K Q E R S D + N L Q +E +
Sbjct: 1653 QLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 543 VFPLSPPDMS--FPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
L +++ +SL+ ++ L +E++R + L ++E Q + E ++ K Q
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/382 (17%), Positives = 159/382 (41%), Gaps = 46/382 (12%)
Query: 243 KLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGE 302
K ++ QK ELK +++ + + ++ +LQ+ +L E R++L + ++ E
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 303 C---------------QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK 347
Q Q + ++ L ++ E + + ++ E ++ K
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 348 IRSQLQQVEEYHN---SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQL-KMELE 403
+ ++ +++ +N E++ + ISDLT L ++E +TK E + ++E+
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPG-EYMSMDFTNREQSRHTSINKLQY 462
+K++ ++Q++ +K K + + + + DL + M +E+ ++ +L
Sbjct: 1050 LKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 463 ENERLRNDLAKL-HVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMP 521
E + N L K+ + G + ++ E ++ K E+ + L + E ++ +
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERA-----ARNKAEKQKRDLGEELEALKTELE 1163
Query: 522 PLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKE--LEKLLNT 579
ST +E+ + + V + L+EE R+ E ++++
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKA----------------LDEETRSHEAQVQEMRQK 1207
Query: 580 HIDELQRHTEFTLNKYSKLKQN 601
H ++ TE L ++ + K N
Sbjct: 1208 HAQAVEELTE-QLEQFKRAKAN 1228
Score = 38.1 bits (87), Expect = 0.023
Identities = 54/279 (19%), Positives = 121/279 (43%), Gaps = 23/279 (8%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ EL++ D + + K + E+K ++LE L ++LA A+ Q E L ++
Sbjct: 1665 QRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK---ELPHLKEE 131
L S +L+ + + + L+A+ ++L E+ + + + RK + L E
Sbjct: 1724 LAS----SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 132 IPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKL------LSEKCNQFQKQA 185
+ E S QK E R + +K E+ + H + + K L K Q ++Q
Sbjct: 1780 LATERSTA-QKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 186 QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
+ + + L+ ++ ++ + ++ E+ + EK + V ++ + +
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 246 DENQKLLQELKMYQRQC-------QAMEAGLSEVKSELQ 277
+E+Q++ + QR+ +AM ++ +KS+L+
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 77.0 bits (188), Expect = 5e-14
Identities = 103/506 (20%), Positives = 226/506 (44%), Gaps = 77/506 (15%)
Query: 18 LQELMEQIDIMVSNKKM---DWERKMRALETRL-----------DLRDQELANAQTCLDQ 63
LQ+ ++ + + + N++ + E+K R + L D RD+ A A+ ++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EK 1481
Query: 64 KGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL--RLHQMKQNKVP 121
+ + + L R ++LE + E + LKA+ L ++ + + +H+++++K
Sbjct: 1482 ETKALSLARALEEALEA-----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-- 1534
Query: 122 RKELPHLKEEIPFELSNLNQKLEEFR-AKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
+ L EE+ +L L +L+ AK R + L L A+ + EK Q
Sbjct: 1535 -RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP-----DPNCEINERDEFI--IEKLKSA 233
Q+Q Y+T+L +++ +++ +L D + I R+E I + KL++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 234 VNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQL 293
+ + + ++ K +++ +++EA L +++ +L + + + ++E+ +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 294 HRELLKIGECQNA-QGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL 352
EL +NA Q K RLE+ I + E +++E +Q N E +++R
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEA----RIAQLEEELEE------EQGNMEAMSDRVRKAT 1763
Query: 353 QQVEEYHN-------------SEQERMRNEISDLTEELHQKE--------ITIATVTKKA 391
QQ E+ N S ++++ + +L +LH+ E TIA + K
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 392 ALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQ 451
A LE+Q +E E +EK A K+++ ++ LK ++ ++ M+ + + +
Sbjct: 1824 AQLEEQ--VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 452 SRHTSINKLQYENERLRNDLAKLHVN 477
+ + +L+ + E + +++ N
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINAN 1899
Score = 67.0 bits (162), Expect = 5e-11
Identities = 99/506 (19%), Positives = 220/506 (43%), Gaps = 48/506 (9%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSL 96
E +M+A E L + A+ L + Q+ L ++ + L++ A T+ Y + + +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-AEAEEM 909
Query: 97 KAQFSKLTNNFEKLRLHQMK----QNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSRE 152
+ + + E++ LH+M+ + + ++L ++++ ++ +L ++LEE A ++
Sbjct: 910 RVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+++ + + L+ + ++ ++ N+ K+ + + +++ L + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-- 1026
Query: 213 PDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEV 272
++ + E +I +L+ + + SR +L+ +KL + + Q ++A ++E+
Sbjct: 1027 -----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 273 K-------SELQSR----DD--------LLRIIEMER--LQLHRELLKIGECQNAQGNKT 311
K ELQ+ DD L +I E+E L +L +N +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 312 RLESSYLPSIK-EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNE- 369
R L ++K E E + + + + E+E+ ++ L + H ++ + MR +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 370 ---ISDLTEELHQKEITIATVTKKAALLEKQ-LKMELEIKEKMLAKQKVSDMKYKAVRTE 425
+ +LTE+L Q + A + K LEK+ + E++ AKQ+V + K K + +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQ 1260
Query: 426 NTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENE----RLRNDLAKLHVNGKST 481
L+ D + D ++ Q+ S+ + E E +L D+A L + T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 482 WTNQNTYEETGRYAYQSQIKVEQNEE 507
Q +E R K+ Q EE
Sbjct: 1321 ---QELLQEETRQKLNVSTKLRQLEE 1343
Score = 61.6 bits (148), Expect = 2e-09
Identities = 115/600 (19%), Positives = 239/600 (39%), Gaps = 40/600 (6%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
EA++QE+ ++ V E+ RA + LD Q L L + + +G +Q+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPF 134
++ +K A Q + + + ++L + KL+ ++++ E ++
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAK 1308
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG 194
++++L+ +L++ + +E +Q++ T L L+ ++ L ++ ++ + Q+ + ++
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 195 KKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQE 254
L DS ++ + E +R + IE L E A + +KL+ +L QE
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 255 LKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERLQLHRELLKIGECQNAQGNK 310
L +S ++ + + D LL I + R + E + +
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 311 TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEI 370
R L + +E ER K L + M+D + + ++ K +L++ + ++ E M+ ++
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 371 SDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLK 430
+L +EL E K+ LE+ + L Q D++ R E K
Sbjct: 1549 EELEDELQATE---------------DAKLRLEVNMQALKGQFERDLQ---ARDEQNEEK 1590
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
EY + R+Q + K ++L DL L + S + +
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAK-----KKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 491 TGRYAYQSQIKVEQNE---ERLSHD-----CEPNRSTMPPLPPSTFQAKEMTSPLVSDDD 542
R Q+Q+K Q E R S D + N L Q +E +
Sbjct: 1646 QLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 543 VFPLSPPDMS--FPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQ 600
L +++ +SL+ ++ L +E++R + L ++E Q + E ++ K Q
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/382 (17%), Positives = 159/382 (41%), Gaps = 46/382 (12%)
Query: 243 KLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGE 302
K ++ QK ELK +++ + + ++ +LQ+ +L E R++L + ++ E
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 303 C---------------QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK 347
Q Q + ++ L ++ E + + ++ E ++ K
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 348 IRSQLQQVEEYHN---SEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQL-KMELE 403
+ ++ +++ +N E++ + ISDLT L ++E +TK E + ++E+
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPG-EYMSMDFTNREQSRHTSINKLQY 462
+K++ ++Q++ +K K + + + + DL + M +E+ ++ +L
Sbjct: 1043 LKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 463 ENERLRNDLAKL-HVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMP 521
E + N L K+ + G + ++ E ++ K E+ + L + E ++ +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERA-----ARNKAEKQKRDLGEELEALKTELE 1156
Query: 522 PLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKE--LEKLLNT 579
ST +E+ + + V + L+EE R+ E ++++
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKA----------------LDEETRSHEAQVQEMRQK 1200
Query: 580 HIDELQRHTEFTLNKYSKLKQN 601
H ++ TE L ++ + K N
Sbjct: 1201 HAQAVEELTE-QLEQFKRAKAN 1221
Score = 38.1 bits (87), Expect = 0.023
Identities = 54/279 (19%), Positives = 121/279 (43%), Gaps = 23/279 (8%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ EL++ D + + K + E+K ++LE L ++LA A+ Q E L ++
Sbjct: 1658 QRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK---ELPHLKEE 131
L S +L+ + + + L+A+ ++L E+ + + + RK + L E
Sbjct: 1717 LAS----SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 132 IPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKL------LSEKCNQFQKQA 185
+ E S QK E R + +K E+ + H + + K L K Q ++Q
Sbjct: 1773 LATERSTA-QKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 186 QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
+ + + L+ ++ ++ + ++ E+ + EK + V ++ + +
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 246 DENQKLLQELKMYQRQC-------QAMEAGLSEVKSELQ 277
+E+Q++ + QR+ +AM ++ +KS+L+
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 73.9 bits (180), Expect = 4e-13
Identities = 126/608 (20%), Positives = 248/608 (40%), Gaps = 86/608 (14%)
Query: 51 DQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL 110
+++L N D+ Q+ KLD + K L N L+S +Q K EK+
Sbjct: 436 EEQLHNEMQLKDEMEQKCRTSNIKLDKIMK-ELDEEGNQRRNLESTVSQIEK-----EKM 489
Query: 111 RL-HQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDA 169
L H++ + + ++ + + E+S L +LE+ + S+
Sbjct: 490 LLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQN----------------- 532
Query: 170 QQKLLSEKCNQFQKQAQSYQTQLNGKKQC---LEDSSSEIPRLICDPDP-NCEINERDEF 225
+L +EK +Q QKQ + L + L S +E+ + I + N E+ ER+
Sbjct: 533 -SQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNR- 590
Query: 226 IIEKLKSAVNE-------IALSRNKLQDENQKLLQELKM----YQRQCQAMEAGLSEVKS 274
I+E KS ++ I + + + + +++ +L+ Q + + ++ L +V+
Sbjct: 591 ILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEG 650
Query: 275 ELQSRDDLLRIIEMERLQLHREL---LKI------GECQNAQGNKTRL-------ESSYL 318
E + D+L E E+ L +L LK E + K RL E +
Sbjct: 651 ERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKS 710
Query: 319 PSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL-------QQVEEYHNSEQERMRNEIS 371
++ E E+K+KE + N ++ K S L QQ E+ +ERM +E+
Sbjct: 711 VAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVK 770
Query: 372 DLTEELHQ---KEITIATVTKKAAL-------LEKQLKMELE--IKEKMLAKQKVSDMKY 419
+LT +L Q K + + K A LEKQ+K E+ ++ K L + +++ +
Sbjct: 771 NLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLT- 829
Query: 420 KAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGK 479
K R ++ + L+ +Y S + + + I + EN + +L N K
Sbjct: 830 KQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQ----NEK 885
Query: 480 STWTNQNTYEETGRYAYQ-SQIKVEQNEERLSHDCEP----NRSTMPPLPPSTFQAKEMT 534
T Q ET + Q ++ +E+ L+ + + NR + + + +E
Sbjct: 886 ETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEAN 945
Query: 535 SPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNK 594
S L D ++ +++ A + + LE+E+ L+ +I+ + +NK
Sbjct: 946 SMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNK 1005
Query: 595 YSKLKQNR 602
+++ +
Sbjct: 1006 LAEIMNRK 1013
Score = 58.2 bits (139), Expect = 2e-08
Identities = 82/438 (18%), Positives = 193/438 (44%), Gaps = 56/438 (12%)
Query: 93 LQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPH----LKEEIPFELSNLNQKLEEFRA 148
L S ++ ++N +K +++ +E H LK+E+ + N KL++
Sbjct: 406 LSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMK 465
Query: 149 KSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPR 208
+ E Q ++ + ++ ++ LL + N++Q++A+ Q N K++ +E+ S +
Sbjct: 466 ELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAE----QENEKRRNVENEVSTLKD 521
Query: 209 LICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAG 268
+ D ++++ + EKL ++ + + L+ E+ ++ K + +++ +
Sbjct: 522 QLEDLK---KVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSI-SQ 577
Query: 269 LSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKI 328
L + ELQ R+ RI+E + Q ++ ++ A+ +S + ++
Sbjct: 578 LESLNRELQERN---RILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQ------ 628
Query: 329 KELFSVMQDQPNHEKELNKIRSQLQQVEEYHN-SEQERMRNEI----------SDLTEEL 377
+ S+ ++ + + L K+ + ++ ++ N SE+E+ EI L +E+
Sbjct: 629 ARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEV 688
Query: 378 HQKEITIATVTKKAALLEK-----QLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGM 432
++ ++T A +T K +E+ +ME ++KE+ A++K + R +
Sbjct: 689 NEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAEN------RVVQIEKQCS 742
Query: 433 MGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQN-----T 487
M D+D + ++++ H + NK + E+E ++N +L QN
Sbjct: 743 MLDVDLKQ-------SQQKLEHLTGNKERMEDE-VKNLTLQLEQESNKRLLLQNELKTQA 794
Query: 488 YEETGRYAYQSQIKVEQN 505
+E + Q+K E N
Sbjct: 795 FEADNLKGLEKQMKQEIN 812
Score = 48.9 bits (115), Expect = 1e-05
Identities = 78/393 (19%), Positives = 163/393 (41%), Gaps = 40/393 (10%)
Query: 32 KKMDWERKMRA-LETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEK--CNLAMTQN 88
KK+ ER+ R E R+ +++ + L Q Q++ L + +E NL +
Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLE 777
Query: 89 YEGQLQSLKAQFSKLTNNFEKLRLHQM-KQNKVPRKELPHLKEEIPFELSNLNQKLEEFR 147
E + L Q T FE L + KQ K L K + FEL+ L ++
Sbjct: 778 QESN-KRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNE 836
Query: 148 AKSREWDKQ-------EILYQTHLISL----DAQQKLLSEKCNQFQKQAQSYQTQLNGKK 196
+ RE Q LY+T + L + + + +K + Q + ++ TQL+ +
Sbjct: 837 GQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAE 896
Query: 197 QCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELK 256
E S ++ R + + + E+ + + + + + + + ++L++ N L ++++
Sbjct: 897 TKAE--SEQLARGLLE-EQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIE 953
Query: 257 MYQRQ----CQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTR 312
+ +R+ + M+ E K E + L+ + + R L KT+
Sbjct: 954 ILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTL------------KTQ 1001
Query: 313 LESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISD 372
+ + + KI + QD EKE K++ +L Q E N + + E++D
Sbjct: 1002 AVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELND 1061
Query: 373 LTEEL-----HQKEITIATVTKKAALLEKQLKM 400
+ +L H+ E+ + +K++ + + + K+
Sbjct: 1062 MQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 45.8 bits (107), Expect = 1e-04
Identities = 57/332 (17%), Positives = 140/332 (42%), Gaps = 34/332 (10%)
Query: 212 DPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSE 271
+P+ N + D+ + E L+ + KL+++ +Q +++C+ L +
Sbjct: 410 NPNDNRTSSNADKSLQESLQKTIY-------KLEEQLHNEMQLKDEMEQKCRTSNIKLDK 462
Query: 272 VKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKEL 331
+ EL + R +E Q+ +E + + N K E+ +++ +K+
Sbjct: 463 IMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQ 522
Query: 332 FSVMQDQPNHEKELNKIRSQLQQVEEYHN----SEQE---RMRNEISDLTEELHQKEITI 384
++ + + N+ SQLQ+ E N +E + R+R +++++ + Q E
Sbjct: 523 LEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLN 582
Query: 385 ATVTKKAALLEK------------QLKMELEIKEKMLAKQKVSDMKYK--AVRTENTHLK 430
+ ++ +LE Q +E E +++ + + D++ + +++ E HLK
Sbjct: 583 RELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLK 642
Query: 431 GMMGDLDPGEYMSMDFTNREQSRHTSIN-----KLQYENERLRNDLAKLHVNGKSTWTNQ 485
+ ++ + D N + ++ KL+ +RL ++ + H K+ T++
Sbjct: 643 HNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNE-HKVTKARLTDK 701
Query: 486 NTYEETGRYAYQSQIKVEQNEERLSHDCEPNR 517
+ E + +++ + EER + + NR
Sbjct: 702 HQSIEEAKSVAMCEMEKKLKEEREAREKAENR 733
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/419 (22%), Positives = 182/419 (43%), Gaps = 52/419 (12%)
Query: 4 QAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQ 63
+A M T + + + E++ + +K E+ + L+ + DL+ Q + + +D
Sbjct: 848 EAEKEMATM--KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 64 KGQEVGLLRQK-------------LDSLEKCN---LAMTQNYEGQLQSLKAQFSKLTNNF 107
+ + GL++ K L+ E+ N +A +N E + SLK L
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 108 EKLRLHQ-MKQNKVPR--KELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHL 164
K+ + +NKV +E+ L+E I +L+ + L+E ++ + + E L
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENIS-KLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 165 ISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDE 224
I ++A+ + ++ +Q + + L K+ LE I D + N++ +
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE-----NDKQQ 1079
Query: 225 FIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLR 284
I EKLK E++ + K+ DE LQ +Q++ + ++A + E++ E+++ L
Sbjct: 1080 -IEEKLKKKEFELSQLQAKIDDEQVHSLQ----FQKKIKELQARIEELEEEIEAEHTLRA 1134
Query: 285 IIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKE 344
IE +R L REL +I E RLE + + + E K E E
Sbjct: 1135 KIEKQRSDLARELEEISE---------RLEEASGATSAQIEMNKK-----------REAE 1174
Query: 345 LNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELE 403
K+R L++ H + +R + +D EL ++ + V +K + +LKME++
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Score = 61.2 bits (147), Expect = 3e-09
Identities = 109/583 (18%), Positives = 218/583 (37%), Gaps = 102/583 (17%)
Query: 31 NKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAM---TQ 87
NK + +M ALE + +E + Q Q ++ + K++ L K N + T
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 88 NYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFR 147
+ EG L+ K + L KL +K ++ +L + K++I +L +L + +
Sbjct: 1037 DLEGSLEQEKKLRADLERAKRKLE-GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 148 AKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIP 207
AK + + +Q + L A+ + L E+ + Q + + LE+ S +
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 208 RLICDPDPNCEINERDEFIIEKLKSAVNEIALSR----------------------NKLQ 245
E+N++ E +K++ + E L + LQ
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 246 DENQKLLQE---LKM------------------YQRQCQAMEAGLSEVKSELQSRDDLLR 284
QKL +E LKM +R C+ +E SE+K++ + + L+
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 285 IIEMERLQLHRE----LLKIGECQNAQGNKTRLESSYLPSIKEPERKIKEL--------- 331
+ M++ +L + ++ E ++ T+ + + ++E +R+++E
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335
Query: 332 --------FSVMQDQPNHEKE--------LNKIRSQLQQVEEYHNSEQERMRNEISD--- 372
++++Q E+E L+K S++ Q + ++ + E+ +
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 373 -LTEELHQKEITIATVTKKAALLEK----------QLKMELEIKEKMLAKQKVSDMKYKA 421
L + L + E T K A LEK L +LE A +
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 422 VRTE-NTHLKGMMGDLDPGEYMSMDFT-------NREQSRHTSINKLQYENERLRNDLAK 473
V E L +L+ + S + N + + L+ EN+ L+ +++
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 474 LHVNGKSTWTNQNTYEETGRYAYQS----QIKVEQNEERLSHD 512
L T N E+T + Q Q+ +E+ E L H+
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
Score = 57.4 bits (137), Expect = 4e-08
Identities = 101/486 (20%), Positives = 187/486 (38%), Gaps = 75/486 (15%)
Query: 15 EAELQELMEQIDIMVSN------KKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEV 68
E E EL +ID M SN K + ER R +E DQ +
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE-----------------DQFSEIK 1264
Query: 69 GLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHL 128
Q+ + N+ + +LQ+ + S E L K + ++L L
Sbjct: 1265 AKDEQQTQLIHDLNMQ-----KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL 1319
Query: 129 KEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSY 188
K ++ E N ++ + D Y+ + Q+ LS+ ++ + Y
Sbjct: 1320 KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY 1379
Query: 189 QTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDEN 248
+T + + LE++ ++ + + + + N E +EK K +LQ E
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTK----------QRLQGEV 1429
Query: 249 QKLLQELKMYQRQCQAMEAG-------LSEVKSELQSRDDLLRIIEMERLQLHRELLKIG 301
+ L+++L+ C ++ L+E K +L L + E L EL K+
Sbjct: 1430 EDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR 1489
Query: 302 ECQNA---QGNKTRLESSYL-PSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQ---- 353
Q R E+ L I + +I E +Q+ +K + + +S LQ
Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE 1549
Query: 354 QVE---EYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLA 410
+VE E+ S+ R++ E+S + EL +K ++EK ++E + A
Sbjct: 1550 EVEGSLEHEESKILRVQLELSQVKSELDRK------------VIEKDEEIEQLKRNSQRA 1597
Query: 411 KQKVSDMKYKAVRTENTHL---KGMMGDLDPGEYMSMDFTNR---EQSRHTSINKLQYEN 464
+ + + +R+ N L K M GDL+ E + + +NR E +H + Q ++
Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEME-IQLGHSNRQMAETQKHLRTVQGQLKD 1656
Query: 465 ERLRND 470
+L D
Sbjct: 1657 SQLHLD 1662
Score = 46.2 bits (108), Expect = 9e-05
Identities = 77/405 (19%), Positives = 157/405 (38%), Gaps = 71/405 (17%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANA-QTCLDQKGQEVGLLRQ 73
+ EL ++ ++D V K + E+ R Q A A Q+ LD + +R
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKR--------NSQRAAEALQSVLDAE------IRS 1611
Query: 74 KLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLH------QMKQNKVPRKELPH 127
+ D+L + + EG L ++ Q + + H Q+K +++ +
Sbjct: 1612 RNDALR-----LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 128 LKEEIPFELSNLNQK-------LEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
E++ +L+ + ++ LEE + + ++ L + L+ + +LL
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL------ 1720
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS 240
S T L K+ LE ++ C + I E EK K A+ + A+
Sbjct: 1721 -----HSQNTSLINTKKKLEADIAQ-----CQAEVENSIQESRN-AEEKAKKAITDAAMM 1769
Query: 241 RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEME--RLQLHRELL 298
+L+ E + M+ L + +LQ R D + ++ + Q+ +
Sbjct: 1770 AEELKKEQDT--------SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEN 1821
Query: 299 KIGECQNAQGNKTRLESSYLPSIKEPERKIKEL-FSVMQDQPN----------HEKELNK 347
++ E +N + + + L + ERK+KE+ + +D N + ++
Sbjct: 1822 RVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKS 1881
Query: 348 IRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAA 392
+ Q ++ EE N++ R R +L E + +I + V K A
Sbjct: 1882 YKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRA 1926
Score = 41.6 bits (96), Expect = 0.002
Identities = 79/399 (19%), Positives = 152/399 (38%), Gaps = 57/399 (14%)
Query: 228 EKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIE 287
E+ K + R +L+++ LLQE Q Q Q+ L + + + ++E
Sbjct: 861 ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE 920
Query: 288 MERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNK 347
K+ E + + S + + E K L +++++
Sbjct: 921 A----------KVKELTERLEEEEEMNSELVAKKRNLEDKCSSL----------KRDIDD 960
Query: 348 IRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEK---QLKMELEI 404
+ L +VE+ E+ N++ +L+EE+ E I+ +TK+ L++ Q +L++
Sbjct: 961 LELTLTKVEK----EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016
Query: 405 KE-------KMLAK--QKVSDMK-----YKAVRTENTHLKGMM-GDLDPGEYMSMDFTNR 449
+E K+ AK Q+ D++ K +R + K + GDL + MD N
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076
Query: 450 EQSRHTSINKLQYENERLRNDLAKLHVNG-------KSTWTNQNTYEETGRYAYQSQIKV 502
+Q + K ++E +L+ + V+ K EE + + K+
Sbjct: 1077 KQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI 1136
Query: 503 EQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHF 562
E+ L+ + E + +T EM ++ F D+ QH
Sbjct: 1137 EKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE---FQKMRRDLE---EATLQHE 1190
Query: 563 LLEEEKRAKELEKL--LNTHIDELQRHTEFTLNKYSKLK 599
R K+ + + L ID LQR + + S+LK
Sbjct: 1191 ATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 70.9 bits (172), Expect = 3e-12
Identities = 88/440 (20%), Positives = 193/440 (43%), Gaps = 47/440 (10%)
Query: 18 LQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDS 77
L+EL E++ N+ E +E RL ++E+ + ++++ ++GL+ +L
Sbjct: 200 LEELTEKL-----NEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQE 254
Query: 78 LEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEK---LRLHQMKQNKVPRKELPHLKEEIPF 134
K A +EG +++ Q N E+ L + Q++ R+ L H EE+
Sbjct: 255 ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG 194
+L+ + + + + KQ+ YQ ++ + + +KQ + QLN
Sbjct: 315 QLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNF 374
Query: 195 K---------KQCLEDSSSEIPRLICDPDP---NCEINERDEF-IIEKLKSAVNEIALSR 241
K+C+E E L + E E+ + ++++LK N
Sbjct: 375 SAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCE 434
Query: 242 NKLQDENQKLLQELKMYQRQCQAMEAGLSEV------KSELQSRDDLLRIIEMERLQL-- 293
+ + + ++ + + + + E LSE+ K E + R + L++ E ++
Sbjct: 435 AERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWK 494
Query: 294 --HRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQ 351
H++L + E Q+ ++ +++ + +KE + +L++ +Q N KELN + ++
Sbjct: 495 LKHKKLERALEKQSETVDELTGKNNQI--LKEKDELKTQLYAALQQIENLRKELNDVLTK 552
Query: 352 LQQVEEYHNSEQERMRN----------EISDLTEELHQKEITIATVTKKAALLEKQLKME 401
EE +S++E++R+ E+ + + +H+ E + KK + ++ Q+K+E
Sbjct: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL----KKQSKIQSQMKVE 608
Query: 402 LEIKEKMLAKQKVSDMKYKA 421
E+ +A+ K S + KA
Sbjct: 609 KAHLEEEIAELKKSQAQDKA 628
Score = 63.5 bits (153), Expect = 5e-10
Identities = 96/488 (19%), Positives = 207/488 (42%), Gaps = 91/488 (18%)
Query: 29 VSNKKMDWERKMRALETRLDLRDQ--ELANAQTCLDQKGQEVGLLRQKLDSL-------E 79
V +K D E++M L +L+ EL + C+++K +E L ++++L E
Sbjct: 354 VEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGE 413
Query: 80 KCNLAMT------QNY----EGQLQSLKAQFSKLTNNFEKLR------LHQMKQNKVPRK 123
K L M QN+ E + + Q S+LT + E L +++Q++ ++
Sbjct: 414 KQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKE 473
Query: 124 ELPHLKEEIPFE------------------LSNLNQKLEEFRAKSREWDKQEILYQTHLI 165
E +E++ + L ++ ++E K+ + K++ +T L
Sbjct: 474 EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLY 533
Query: 166 SLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEF 225
+ Q + L ++ N + + +L+ K++ L D S L + + + R E
Sbjct: 534 AALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLES 593
Query: 226 IIEKLKSAVNEIALSRNKLQDE-----------NQKLLQ-----------------ELKM 257
++K +++ + + L++E KLL+ +L
Sbjct: 594 ELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAE 653
Query: 258 YQRQCQAMEAGLSEVKSELQSRDD----LLRIIEMERLQLHRELLKIGECQNAQGNKTRL 313
+R +A+ LS++ ++ +SRD+ ++ +++ER REL + + Q KT+
Sbjct: 654 EERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDL--TSSLQSVKTKH 711
Query: 314 ESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDL 373
E + +K +++ E NH + L + + + + H + E+++++ L
Sbjct: 712 EQNIQELMKHFKKEKSEA-------ENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRL 764
Query: 374 TEELHQKEITIATVTKKAALLEKQL---KMELEIKEKMLAKQKVSDMKYK----AVRTEN 426
TEEL Q E + K L+ QL + + I+E+ L + + + ++ K + TE
Sbjct: 765 TEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQ 824
Query: 427 THLKGMMG 434
+ G++G
Sbjct: 825 ESILGVIG 832
Score = 60.8 bits (146), Expect = 3e-09
Identities = 108/566 (19%), Positives = 225/566 (39%), Gaps = 92/566 (16%)
Query: 17 ELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLD 76
+LQE +++ + + + K+R ET + +QEL ++ L+Q L +++
Sbjct: 251 QLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVE 310
Query: 77 SLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFE-------KLRLHQMKQNKVPRKELPHLK 129
L + L + LQ +Q SK +N++ + R ++ + K++ L+
Sbjct: 311 EL-RTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLR 369
Query: 130 EEIPF-------------------ELSNLNQKLEEFRAKSREWDKQEIL-------YQTH 163
++ F E ++L ++E + +KQ++ Q H
Sbjct: 370 VQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNH 429
Query: 164 LISLDAQQK-------LLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPN 216
+ +A++K L+ KQA+ Y ++L + E++ L +
Sbjct: 430 FDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQES 489
Query: 217 CE----INERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEV 272
+++ E +EK V+E+ N++ E +L +L +Q + + L++V
Sbjct: 490 IRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV 549
Query: 273 -------KSELQSRDDLLRIIEMER----LQLHRELLKIGECQNAQGNKTRLESSYLPSI 321
+ EL S+++ LR I+ + L++ L I ++ +++++S
Sbjct: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
Query: 322 KEPERKIKEL-FSVMQDQ------PNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLT 374
E +I EL S QD+ K+L+ IR+ L ++ + ++SDLT
Sbjct: 610 AHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLT 669
Query: 375 EELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTEN-----THL 429
+ ++ AT+ QLK+E ++ ++ L S K +N H
Sbjct: 670 AQAKSRDEETATII-------TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHF 722
Query: 430 KGMMGDLDPG----EYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQ 485
K + + + S++ N + + KL+ + +RL +L + N+
Sbjct: 723 KKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ----------NE 772
Query: 486 NTYEETGRYAYQSQIKVEQNEERLSH 511
N E + + Q +Q EER H
Sbjct: 773 N---ENKKLKLKYQCLKDQLEEREKH 795
Score = 41.6 bits (96), Expect = 0.002
Identities = 72/341 (21%), Positives = 147/341 (43%), Gaps = 43/341 (12%)
Query: 190 TQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQ 249
TQL+G Q L D SSE RL D N E++ R E K A+ E+ N+ Q Q
Sbjct: 159 TQLHGFHQSLRDLSSEQIRL--GDDFNRELSRRSRSDAE-TKRALEELTEKLNEAQ--KQ 213
Query: 250 KLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQ-LHRELLKIGECQNAQG 308
+++ + +R+ Q +E + + ++ R D L ++ ++ + L ++ K E + A
Sbjct: 214 EVVSD--RVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIK 271
Query: 309 NK---TRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQER 365
NK T E + L E R++ ++ H+ E ++R+QL + E +++
Sbjct: 272 NKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVE--ELRTQLTKAE----GDRKG 325
Query: 366 MRNEISDLTEELHQKEITIAT-------VTKKAALLEKQLK----------MELEIKE-K 407
+++++S ++++ + V ++ LEKQ+ M E++E K
Sbjct: 326 LQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVK 385
Query: 408 MLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERL 467
++K + + A + EN + +L+ GE + +R + + + E +
Sbjct: 386 RCMERKDKEKAHLASQVEN-----LTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHA 440
Query: 468 RNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEER 508
+++L + + Y QS+ E+ E+R
Sbjct: 441 DLQISELTRHAEDATKQAERYLSE---LQQSEALKEEAEKR 478
Score = 33.5 bits (75), Expect = 0.58
Identities = 60/260 (23%), Positives = 109/260 (41%), Gaps = 62/260 (23%)
Query: 74 KLDSLEKCNLAMTQNYEGQLQSLKAQFSKLT-------NNFEKLRL-HQMKQNKVPRKEL 125
K +SLE+ N+A + GQL+ LK+Q +LT N +KL+L +Q ++++ +E
Sbjct: 737 KAESLEEKNMAKI--HRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREK 794
Query: 126 ------PHLK--EEIPFELSNLNQKLE------------EFRAKSREWDKQ--------- 156
HL+ EE +L + LE E A + + K
Sbjct: 795 HISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
Query: 157 ---EILYQTHLISLDAQQKL--LSEKCNQFQKQAQSYQTQLNGKKQCL----EDSSSEIP 207
+I Y H +++ KL L E+ + + + ++ + QL +Q L E+ SE+
Sbjct: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
Query: 208 RLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEA 267
L IE+ + ++EI + L +E Q+ +E+ Q + A+E
Sbjct: 915 CLFQQ--------------IERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET 960
Query: 268 GLSEVKSELQSRDDLLRIIE 287
L+S + L ++E
Sbjct: 961 STQVALDHLESVPEKLSLLE 980
Score = 30.0 bits (66), Expect = 6.4
Identities = 34/176 (19%), Positives = 79/176 (44%), Gaps = 26/176 (14%)
Query: 276 LQSRDDLLRI--IEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFS 333
+Q DD+ ++ L E +++G+ N + ++ + E +R ++EL
Sbjct: 152 VQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDA------ETKRALEELTE 205
Query: 334 VMQDQPNHEKELNKIRSQLQQVEEYHNSEQ---ERMRNEIS----DLTEELHQKEI---- 382
+ + E +++ +LQ++E +E+ ER ++++ L E L ++E
Sbjct: 206 KLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE 265
Query: 383 ---TIATVTKKAALLEKQLKMELEIKEKMLAKQKVSD----MKYKAVRTENTHLKG 431
I ++ + QL+ ELE+ ++L + + S + + +RT+ T +G
Sbjct: 266 HEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEG 321
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 69.3 bits (168), Expect = 1e-11
Identities = 108/515 (20%), Positives = 204/515 (39%), Gaps = 107/515 (20%)
Query: 18 LQELMEQIDIMVSN--KKMDWERKMRALETRLDLRDQELANAQTCLDQ-KGQEVGLLRQK 74
++EL +D + N K + E++ + L ++++ + E+ + L + L+++K
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQM-----------KQNKVPR- 122
LEK + +N E Q++ L+ + L LR K+NK+
Sbjct: 536 AQ-LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 594
Query: 123 --KELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
KE +I FE + ++LE ++ K ++ E L L+ + +LL +K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE----NELHHLEKENELLQKKITN 650
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS 240
+ + K + LE +SE+ ER+ ++K + +
Sbjct: 651 LKITCE--------KIEALEQENSEL--------------ERENRKLKKTLDSFKNLTFQ 688
Query: 241 RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI 300
L+ EN +L +E +R ++++ ++ ++LQ +E + L+ +E LK
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQ--------LENKELESEKEQLKK 739
Query: 301 G-ECQNAQGNKT-RLESSYL----------PSIKEPERKIKELFSVMQD--------QPN 340
G E A KT RLE SY +++ +KI++L S +QD Q N
Sbjct: 740 GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 341 HE----------------KELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITI 384
E K L + SQL++ ++ E +R+R + L + + I
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 385 ATVTKKAALLEKQLKM---------ELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGD 435
+ K+ L K++ + ELE + K L K+ D+K E D
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE---------D 910
Query: 436 LDPGEYMSMDFTNREQSRHTSINKLQYENERLRND 470
L + + N + + K+ ERL +D
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
Score = 68.9 bits (167), Expect = 1e-11
Identities = 99/468 (21%), Positives = 204/468 (43%), Gaps = 37/468 (7%)
Query: 35 DWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQ 94
D + K+R L L+ + ++L + + L+Q E+ L+Q+ +L + + Y +L
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS-DARSARMYRDELD 313
Query: 95 SLK---AQFSKLTNNFE--KLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAK 149
+L+ + KL + K RLH ++ K +EL + + + L +LE RA+
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 150 S---REWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEI 206
S E +K+ + + L ++ ++ + +K + ++ + + +KQ +++S
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM---AQKQSMDESL--- 427
Query: 207 PRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRN-KLQDENQKLLQELKMYQRQCQAM 265
L + + +E E + L VNE+ SR KL+ ENQ L + ++ + ++
Sbjct: 428 -HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 266 EAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGN----KTRLESSYLPSI 321
E S++ + L + +E+ ++ +E + CQN + K +LE +
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 322 KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQER--MRNEISDLTEELHQ 379
+ ER+IK + + N + RSQ+ + E+E + I + + +L +
Sbjct: 547 ENSERQIK-ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 380 KEITIATVTK----------KAALLEKQ---LKMELEIKEKMLAKQKVSDMKYKAVRTEN 426
E + K +A LE + L+ E E+ +K + K++ K +A+ EN
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 427 THLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKL 474
+ L+ L + T + +S ++L EN LR ++ L
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Score = 57.4 bits (137), Expect = 4e-08
Identities = 115/502 (22%), Positives = 214/502 (42%), Gaps = 71/502 (14%)
Query: 11 TSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGL 70
TS E + ++L ++ NK++ + +++ +T L+ + ++ N + +E+G+
Sbjct: 824 TSQLEKDKKQLEKE------NKRLRQQAEIK--DTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 71 LRQ---KLDSLEKCNLAMTQNYEGQLQSL----------KAQFSKLTNNFEKLRLHQMKQ 117
++ +L LEK N + + +++L K + ++ N+ EKL H++++
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT-HELEK 934
Query: 118 NKVPRKELPHLKEEIP-FELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSE 176
+ ++ L H ++ L KLE KS E +++I A + L E
Sbjct: 935 IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA---------ALEARLEE 985
Query: 177 KCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEIN----ERDEFIIEKLKS 232
N Q+ Q +T + + L+ E + P + E N E E E LK
Sbjct: 986 STNYNQQLRQELKT-VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1044
Query: 233 AVNEIALSRNK--LQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMER 290
I + RN LQ E Q L +LK + Q ++A + ++ + S + ++ +
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104
Query: 291 LQLHRELLKIGE------CQNAQ--GNKTRLESSYLPSIKEPERKIKELF-SVMQDQPNH 341
+L E + QNAQ ++ LE+ IKE E +K L+ S+++D
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE-DLKSLYDSLIKDHEKL 1163
Query: 342 EKELNKIRSQLQQVEEYHNSEQERMRN---EISDLTEELHQKEITIATVTKKAAL--LEK 396
E + S+ + + H + + +N E DL + +Q + +K L LEK
Sbjct: 1164 ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEK 1217
Query: 397 QLKMELEIKEKMLAKQKVSD---MKYKAVRTENTHLKGMMGD-LDPGEYMSMDFTNREQS 452
LK+E +EKML + K + +YK + EN L L E + D N +
Sbjct: 1218 MLKVE---QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK-- 1272
Query: 453 RHTSINKLQYENERLRNDLAKL 474
+ +N + E RL + +KL
Sbjct: 1273 --SLLNNSKLEQTRLEAEFSKL 1292
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 69.3 bits (168), Expect = 1e-11
Identities = 108/515 (20%), Positives = 204/515 (39%), Gaps = 107/515 (20%)
Query: 18 LQELMEQIDIMVSN--KKMDWERKMRALETRLDLRDQELANAQTCLDQ-KGQEVGLLRQK 74
++EL +D + N K + E++ + L ++++ + E+ + L + L+++K
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQM-----------KQNKVPR- 122
LEK + +N E Q++ L+ + L LR K+NK+
Sbjct: 536 AQ-LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 594
Query: 123 --KELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
KE +I FE + ++LE ++ K ++ E L L+ + +LL +K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE----NELHHLEKENELLQKKITN 650
Query: 181 FQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALS 240
+ + K + LE +SE+ ER+ ++K + +
Sbjct: 651 LKITCE--------KIEALEQENSEL--------------ERENRKLKKTLDSFKNLTFQ 688
Query: 241 RNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKI 300
L+ EN +L +E +R ++++ ++ ++LQ +E + L+ +E LK
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQ--------LENKELESEKEQLKK 739
Query: 301 G-ECQNAQGNKT-RLESSYL----------PSIKEPERKIKELFSVMQD--------QPN 340
G E A KT RLE SY +++ +KI++L S +QD Q N
Sbjct: 740 GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 341 HE----------------KELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITI 384
E K L + SQL++ ++ E +R+R + L + + I
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 385 ATVTKKAALLEKQLKM---------ELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGD 435
+ K+ L K++ + ELE + K L K+ D+K E D
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE---------D 910
Query: 436 LDPGEYMSMDFTNREQSRHTSINKLQYENERLRND 470
L + + N + + K+ ERL +D
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
Score = 68.9 bits (167), Expect = 1e-11
Identities = 99/468 (21%), Positives = 204/468 (43%), Gaps = 37/468 (7%)
Query: 35 DWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQ 94
D + K+R L L+ + ++L + + L+Q E+ L+Q+ +L + + Y +L
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS-DARSARMYRDELD 313
Query: 95 SLK---AQFSKLTNNFE--KLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAK 149
+L+ + KL + K RLH ++ K +EL + + + L +LE RA+
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 150 S---REWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEI 206
S E +K+ + + L ++ ++ + +K + ++ + + +KQ +++S
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM---AQKQSMDESL--- 427
Query: 207 PRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRN-KLQDENQKLLQELKMYQRQCQAM 265
L + + +E E + L VNE+ SR KL+ ENQ L + ++ + ++
Sbjct: 428 -HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 266 EAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGN----KTRLESSYLPSI 321
E S++ + L + +E+ ++ +E + CQN + K +LE +
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 322 KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQER--MRNEISDLTEELHQ 379
+ ER+IK + + N + RSQ+ + E+E + I + + +L +
Sbjct: 547 ENSERQIK-ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 380 KEITIATVTK----------KAALLEKQ---LKMELEIKEKMLAKQKVSDMKYKAVRTEN 426
E + K +A LE + L+ E E+ +K + K++ K +A+ EN
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 427 THLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKL 474
+ L+ L + T + +S ++L EN LR ++ L
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Score = 61.6 bits (148), Expect = 2e-09
Identities = 115/501 (22%), Positives = 214/501 (42%), Gaps = 70/501 (13%)
Query: 11 TSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGL 70
TS E + ++L ++ NK++ + +++ +T L+ + ++ N + +E+G+
Sbjct: 824 TSQLEKDKKQLEKE------NKRLRQQAEIK--DTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 71 LRQ---KLDSLEKCNLAMTQNYEGQLQSL----------KAQFSKLTNNFEKLRLHQMKQ 117
++ +L LEK N + + +++L K + ++ N+ EKL H++++
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT-HELEK 934
Query: 118 NKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEK 177
+ ++ L H ++ L KLE KS E +++I A + L E
Sbjct: 935 IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA---------ALEARLEES 985
Query: 178 CNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEIN----ERDEFIIEKLKSA 233
N Q+ Q +T + + L+ E + P + E N E E E LK
Sbjct: 986 TNYNQQLRQELKT-VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 234 VNEIALSRNK--LQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERL 291
I + RN LQ E Q L +LK + Q ++A + ++ + S + ++ +
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 292 QLHRELLKIGE------CQNAQ--GNKTRLESSYLPSIKEPERKIKELF-SVMQDQPNHE 342
+L E + QNAQ ++ LE+ IKE E +K L+ S+++D E
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE-DLKSLYDSLIKDHEKLE 1163
Query: 343 KELNKIRSQLQQVEEYHNSEQERMRN---EISDLTEELHQKEITIATVTKKAAL--LEKQ 397
+ S+ + + H + + +N E DL + +Q + +K L LEK
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEKM 1217
Query: 398 LKMELEIKEKMLAKQKVSD---MKYKAVRTENTHLKGMMGD-LDPGEYMSMDFTNREQSR 453
LK+E +EKML + K + +YK + EN L L E + D N +
Sbjct: 1218 LKVE---QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK--- 1271
Query: 454 HTSINKLQYENERLRNDLAKL 474
+ +N + E RL + +KL
Sbjct: 1272 -SLLNNSKLEQTRLEAEFSKL 1291
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 69.3 bits (168), Expect = 1e-11
Identities = 96/435 (22%), Positives = 188/435 (43%), Gaps = 54/435 (12%)
Query: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
M+NQ+ N EL+ +Q + + + E + +E L+ R +EL+ Q
Sbjct: 156 MKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEE 215
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQN-----------------YEGQLQSLKAQFSKL 103
L Q L QKL+ L++ + + E + Q L+A +L
Sbjct: 216 LMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQL 275
Query: 104 TNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTH 163
+ + +K+ ++ V + HL+E++ ++L ++LE+ S E QE+L +
Sbjct: 276 SIDLQKVTAETQEKEDV----ITHLQEKV----ASLEKRLEQ--NLSGEEHVQELLKEKT 325
Query: 164 LISL---DAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEIN 220
L D +Q+LL+ + +Q K + +T++ +Q L+ S ++
Sbjct: 326 LAEQNLEDTRQQLLAARSSQ-AKAINTLETRVRELEQTLQASEEQL-------------- 370
Query: 221 ERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRD 280
++ + I+ ++ + E+A + + Q+ L + + + QA+EA + ++ ++R
Sbjct: 371 QQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALE---RTRA 427
Query: 281 DLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPN 340
E QL +E + EC+N + L +KE E +E+ SV Q
Sbjct: 428 ADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKE-EWSQREIVSVAMAQA- 485
Query: 341 HEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTK--KAALLE-KQ 397
+E+ K R + QQ + + + + TE L QKE I + + +ALL+ Q
Sbjct: 486 -LEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQ 544
Query: 398 LKMELEIKEKMLAKQ 412
L+ ELE + A++
Sbjct: 545 LQAELEALRTLKAEE 559
Score = 39.3 bits (90), Expect = 0.011
Identities = 72/333 (21%), Positives = 145/333 (43%), Gaps = 48/333 (14%)
Query: 39 KMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMT---QNYEGQLQS 95
+ +ALE ++ ++ A QT +Q ++ L Q+ +L++C QN++ +L+
Sbjct: 411 RTQALEAQIVALERTRAADQTTAEQGMRQ---LEQENAALKECRNEYERSLQNHQFELKK 467
Query: 96 LKAQFSK-------LTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRA 148
LK ++S+ + E++R KQ + +++ +L I + NL +K E
Sbjct: 468 LKEEWSQREIVSVAMAQALEEVR----KQREEFQQQAANLTAIIDEKEQNLREKTEVLLQ 523
Query: 149 KSREWDKQE-----ILYQTHLIS--LDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLED 201
K +E + E L Q H + L+A + L +E+ +Q + + + + L
Sbjct: 524 KEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSV 583
Query: 202 SSSEIP-RLICDP---------DPNCEINERDEFIIEKLKSAVNEIALSRNK-LQDENQK 250
+ S + R + DP PN E+ D ++K K + + L +NK ++ Q+
Sbjct: 584 NESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQR 643
Query: 251 LLQELKMYQRQCQAM-EAGLSEVKSE-----------LQSRDDLLRIIEMERLQLHRELL 298
+L+ K Q++ + + L EV+ + + + DL E+ L +L
Sbjct: 644 MLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVL 703
Query: 299 KIGECQNAQG-NKTRLESSYLPSIKEPERKIKE 330
K C+ ++ + + S L +E E +KE
Sbjct: 704 KFMSCRESEAFHLIKAVSVLLNFSQEEENMLKE 736
Score = 33.5 bits (75), Expect = 0.58
Identities = 48/213 (22%), Positives = 96/213 (45%), Gaps = 24/213 (11%)
Query: 227 IEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRII 286
++K+K + EIAL ++ QD + + QE QA A ++E + +R D
Sbjct: 84 LQKIKEKL-EIALEKH--QDSSMRKFQE---QNETFQANRAKMAEGLALALARKDQEWSE 137
Query: 287 EMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELN 346
+M++L+ + +L AQ + + +S L ++ ++ EL Q +EL+
Sbjct: 138 KMDQLEKEKNIL------TAQLQEMKNQSMNLFQRRD---EMDELEGFQQ------QELS 182
Query: 347 KIRSQLQQVEEY---HNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELE 403
KI+ L + EE E E E+S EEL + +++K L++ E
Sbjct: 183 KIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEE 242
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDL 436
++ ++A + ++ K A+ + L+ ++ L
Sbjct: 243 QRDHVIASKTGAESKITALEQKEQELQALIQQL 275
Score = 30.0 bits (66), Expect = 6.4
Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 13/153 (8%)
Query: 327 KIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERM---RNEISDLTEELHQKEIT 383
+I++L + + D + L KI+ +L+ E H R +NE + +
Sbjct: 66 QIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
Query: 384 IATVTKKAALLEK--QLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKG-MMGDLDPGE 440
+A K EK QL+ E I L + K M R E L+G +L +
Sbjct: 126 LALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIK 185
Query: 441 YMSMDFTNREQSRHTSINKLQYENERLRNDLAK 473
+M + + S+ K++ E E +L++
Sbjct: 186 HMLL-------KKEESLGKMEQELEARTRELSR 211
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 68.9 bits (167), Expect = 1e-11
Identities = 89/465 (19%), Positives = 199/465 (42%), Gaps = 35/465 (7%)
Query: 52 QELANAQTCLDQKGQEVGL---LRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLT--NN 106
QE Q L + Q+V L Q+L + C+ A+ E L L+A F+ T +
Sbjct: 88 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 147
Query: 107 FEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLIS 166
+ + + K K L K+ + +++ R + +Q+ ++
Sbjct: 148 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 207
Query: 167 LDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFI 226
L+ L E+ + ++ T L + Q L+ +E +L D + E+DE +
Sbjct: 208 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKF--LQEKDEML 265
Query: 227 --IEKLKSAVNEIALSRNKLQDENQKLLQELKMY----------QRQCQAMEAGLSEVKS 274
+EK + V L + K ++ Q + EL+M + +C+A++A + ++K+
Sbjct: 266 QELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKN 325
Query: 275 ELQSRDDLLRIIEMERLQLHRELLKIG----ECQNAQGNKTRLESSYLPSIKEPERKI-- 328
L+ R+ + Q E G + Q L+ +I+E +R++
Sbjct: 326 SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM 385
Query: 329 --KELFSVMQDQPNHEKELNKIRSQLQQ-VEEYHNSEQERMRNEISDLTEELHQKEITIA 385
KE ++Q ++ K + ++ +L + + + NS++E+ + + + +++ ++
Sbjct: 386 LQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM--- 442
Query: 386 TVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMD 445
+ + +Q ++ +++E + K+ + K + ++ H K M G+L E + +
Sbjct: 443 -LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGEL---EALRQE 498
Query: 446 FTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
F ++++ + KL+ ENE LR +L +S+ NT ++
Sbjct: 499 FKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQ 543
Score = 49.3 bits (116), Expect = 1e-05
Identities = 98/488 (20%), Positives = 207/488 (42%), Gaps = 56/488 (11%)
Query: 15 EAELQELMEQIDIMVSNK-KMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQ 73
+ LQEL Q++ + K + ++ ++ + L +++L Q L +K +E+ +
Sbjct: 234 QCRLQEL--QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC 291
Query: 74 KLDSLEKC--NLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEE 131
LE ++ E + ++L+A+ KL N+ E+ + +Q ++ ++ KEE
Sbjct: 292 MATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK----QQERLAAQQAAQCKEE 347
Query: 132 IPF---ELSNLNQKLEE--FRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQ 186
L + +KL++ K + QE+ Q L L + + ++ +K+ +
Sbjct: 348 AALAGCHLEDTQRKLQKGLLLDKQKADTIQEL--QRELQMLQKESSMAEKEQTSNRKRVE 405
Query: 187 SYQTQLNGKKQCLEDSSSE---IPRLICDPD-------PNCEINERDEFIIE-KLKSAVN 235
+L+ + LE+S E + + + + D + R++ I+ KL+ +
Sbjct: 406 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 465
Query: 236 EIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERL 291
E + L+D+ + +LK + + ME L ++ E + +D L R +E E
Sbjct: 466 E---ATKLLEDKRE----QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
Query: 292 QLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQ 351
L EL + NK + + + KE S+M Q +K L K +
Sbjct: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE--SLMSLQAQLDKALQKEKHY 576
Query: 352 LQQ--VEEYHNSEQERMRNEISDLTEELHQ-KEITIATVTKKAALLEKQLKMELEIKEKM 408
LQ +E +++ + DLT+ L + +T T + + +L + Q K + +++E++
Sbjct: 577 LQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEK-KAQLEEEI 635
Query: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLD--------PGEYMSMDFTNREQSRHTSINKL 460
+A ++ + K + TE L+G + + E MS ++ + L
Sbjct: 636 IAYEE----RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 691
Query: 461 QYENERLR 468
+ E+LR
Sbjct: 692 AAKEEQLR 699
Score = 45.4 bits (106), Expect = 1e-04
Identities = 86/481 (17%), Positives = 183/481 (38%), Gaps = 69/481 (14%)
Query: 2 ENQAHNTMGTSPCEAELQELMEQIDIMVSNKKM------DWERKMRALETRLDLRDQELA 55
+ Q N EL E + +++ K+ + + KM + R+ + +E
Sbjct: 395 KEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 454
Query: 56 NAQTCLDQKGQEVG-LLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQ 114
+ + L++ QE LL K + L+K + EG+L++L+ +F K ++
Sbjct: 455 SIKCKLEEDLQEATKLLEDKREQLKKSK-EHEKLMEGELEALRQEFKKKDKTLKENSRKL 513
Query: 115 MKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQ-QKL 173
++N+ R EL ++ L+ N + + + +K+ L + L+SL AQ K
Sbjct: 514 EEENENLRAELQCCSTQLESSLNKYNTSQQVIQ----DLNKEIALQKESLMSLQAQLDKA 569
Query: 174 LSEKCNQFQKQA--QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLK 231
L ++ + Q ++Y C +D + + +L +
Sbjct: 570 LQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKL------------------NHVT 611
Query: 232 SAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKS-------ELQSRDDLLR 284
S + S + Q++ +L +E+ Y+ + + + L +++ E+ + D L
Sbjct: 612 SETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 671
Query: 285 IIEMERLQLHRE--------LLKIGECQNAQGNKTRLESSYLPSIKEP------------ 324
+ + LQ ++ K + + Q L+ + L KEP
Sbjct: 672 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDT 731
Query: 325 ---ERKIKELFSVMQDQPNHEKELN-KIRSQLQQVEEY-----HNSEQERMRNEISDLTE 375
R ++ + ++ +K N K+ +QL++ +Y ++E R + T
Sbjct: 732 CRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTR 791
Query: 376 ELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGD 435
+ +V K+LK E+E K+ ++ RTE+T + + G
Sbjct: 792 PSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGT 851
Query: 436 L 436
L
Sbjct: 852 L 852
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 68.9 bits (167), Expect = 1e-11
Identities = 89/465 (19%), Positives = 199/465 (42%), Gaps = 35/465 (7%)
Query: 52 QELANAQTCLDQKGQEVGL---LRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLT--NN 106
QE Q L + Q+V L Q+L + C+ A+ E L L+A F+ T +
Sbjct: 233 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 292
Query: 107 FEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLIS 166
+ + + K K L K+ + +++ R + +Q+ ++
Sbjct: 293 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 352
Query: 167 LDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFI 226
L+ L E+ + ++ T L + Q L+ +E +L D + E+DE +
Sbjct: 353 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKF--LQEKDEML 410
Query: 227 --IEKLKSAVNEIALSRNKLQDENQKLLQELKMY----------QRQCQAMEAGLSEVKS 274
+EK + V L + K ++ Q + EL+M + +C+A++A + ++K+
Sbjct: 411 QELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKN 470
Query: 275 ELQSRDDLLRIIEMERLQLHRELLKIG----ECQNAQGNKTRLESSYLPSIKEPERKI-- 328
L+ R+ + Q E G + Q L+ +I+E +R++
Sbjct: 471 SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM 530
Query: 329 --KELFSVMQDQPNHEKELNKIRSQLQQ-VEEYHNSEQERMRNEISDLTEELHQKEITIA 385
KE ++Q ++ K + ++ +L + + + NS++E+ + + + +++ ++
Sbjct: 531 LQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM--- 587
Query: 386 TVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMD 445
+ + +Q ++ +++E + K+ + K + ++ H K M G+L E + +
Sbjct: 588 -LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGEL---EALRQE 643
Query: 446 FTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEE 490
F ++++ + KL+ ENE LR +L +S+ NT ++
Sbjct: 644 FKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQ 688
Score = 51.2 bits (121), Expect = 3e-06
Identities = 85/463 (18%), Positives = 185/463 (39%), Gaps = 53/463 (11%)
Query: 2 ENQAHNTMGTSPCEAELQELMEQIDIMVSNKKM------DWERKMRALETRLDLRDQELA 55
+ Q N EL E + +++ K+ + + KM + R+ + +E
Sbjct: 540 KEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 599
Query: 56 NAQTCLDQKGQEVG-LLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQ 114
+ + L++ QE LL K + L+K + EG+L++L+ +F K ++
Sbjct: 600 SIKCKLEEDLQEATKLLEDKREQLKKSK-EHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
Query: 115 MKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQ-QKL 173
++N+ R EL ++ L+ N + + + +K+ L + L+SL AQ K
Sbjct: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQVIQ----DLNKEIALQKESLMSLQAQLDKA 714
Query: 174 LSEKCNQFQKQA--QSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLK 231
L ++ + Q ++Y C +D + + +L +
Sbjct: 715 LQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKL------------------NHVT 756
Query: 232 SAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKS-------ELQSRDDLLR 284
S + S + Q++ +L +E+ Y+ + + + L +++ E+ + D L
Sbjct: 757 SETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 816
Query: 285 IIEMERLQLHRE--------LLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQ 336
+ + LQ ++ K + + Q L+ + L KEP +SV +
Sbjct: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEP--CCLPQWSVPK 874
Query: 337 DQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTE---ELHQKEITIATVTKKAAL 393
D + ++I + L+Q + E++ N++ + + +L ++ + +V
Sbjct: 875 DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQ 934
Query: 394 LEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDL 436
K+LK E+E K+ ++ RTE+T + + G L
Sbjct: 935 ENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 977
Score = 49.3 bits (116), Expect = 1e-05
Identities = 98/488 (20%), Positives = 207/488 (42%), Gaps = 56/488 (11%)
Query: 15 EAELQELMEQIDIMVSNK-KMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQ 73
+ LQEL Q++ + K + ++ ++ + L +++L Q L +K +E+ +
Sbjct: 379 QCRLQEL--QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC 436
Query: 74 KLDSLEKC--NLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEE 131
LE ++ E + ++L+A+ KL N+ E+ + +Q ++ ++ KEE
Sbjct: 437 MATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK----QQERLAAQQAAQCKEE 492
Query: 132 IPF---ELSNLNQKLEE--FRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQ 186
L + +KL++ K + QE+ Q L L + + ++ +K+ +
Sbjct: 493 AALAGCHLEDTQRKLQKGLLLDKQKADTIQEL--QRELQMLQKESSMAEKEQTSNRKRVE 550
Query: 187 SYQTQLNGKKQCLEDSSSE---IPRLICDPD-------PNCEINERDEFIIE-KLKSAVN 235
+L+ + LE+S E + + + + D + R++ I+ KL+ +
Sbjct: 551 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 610
Query: 236 EIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLL----RIIEMERL 291
E + L+D+ + +LK + + ME L ++ E + +D L R +E E
Sbjct: 611 E---ATKLLEDKRE----QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 663
Query: 292 QLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQ 351
L EL + NK + + + KE S+M Q +K L K +
Sbjct: 664 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE--SLMSLQAQLDKALQKEKHY 721
Query: 352 LQQ--VEEYHNSEQERMRNEISDLTEELHQ-KEITIATVTKKAALLEKQLKMELEIKEKM 408
LQ +E +++ + DLT+ L + +T T + + +L + Q K + +++E++
Sbjct: 722 LQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEK-KAQLEEEI 780
Query: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLD--------PGEYMSMDFTNREQSRHTSINKL 460
+A ++ + K + TE L+G + + E MS ++ + L
Sbjct: 781 IAYEE----RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 836
Query: 461 QYENERLR 468
+ E+LR
Sbjct: 837 AAKEEQLR 844
Score = 41.6 bits (96), Expect = 0.002
Identities = 100/481 (20%), Positives = 189/481 (39%), Gaps = 127/481 (26%)
Query: 99 QFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEI 158
+ S L + L+L + V +++ L++ +N ++ +A++ +++ E+
Sbjct: 11 EVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEV 70
Query: 159 LY----QTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQ---CLEDSSSEIPRLIC 211
+ Q HL L +K L + + + QT +Q LE +S++ L
Sbjct: 71 EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL-- 128
Query: 212 DPDPNCEINERDEFII-------------EKLKSAVNEIALSRNKL----------QDEN 248
+C++ E DE I+ EKL A ++AL+ +K+ +D+
Sbjct: 129 --HHHCKLKE-DEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY 185
Query: 249 Q-------------KLLQ------------------ELKMYQRQC-----QAMEAGLSEV 272
Q K+LQ ++++Y C Q + LSEV
Sbjct: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEV 245
Query: 273 KSELQSRDDLLRIIE-----MERLQLHRE--LLKIGECQNAQGNKTRLESSYLPSIKEPE 325
++ +DDL++ + L L RE L+K+ A Y PS E
Sbjct: 246 WQKVSQQDDLIQELRNKLACSNALVLEREKALIKL----QADFASCTATHRYPPSSSEEC 301
Query: 326 RKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHN------------SEQER-MRNEISD 372
IK++ +Q+Q + SQ VEEY N SEQ+R + ++
Sbjct: 302 EDIKKILKHLQEQKD---------SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 352
Query: 373 LTEELH-------------QKEITIATVTKKAALLEKQLKMELEIKEKMLAKQK---VSD 416
L +LH K+ITI + LE +L +K+ ++K + +
Sbjct: 353 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQE 412
Query: 417 MKYKAVRTENTHLKGMMGDLDPGEYMSMDF------TNREQSRHTSINKLQYENERLRND 470
++ K + +N+ LK +L+ + M+ + +++S+ LQ E ++L+N
Sbjct: 413 LEKKLTQVQNSLLK-KEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS 471
Query: 471 L 471
L
Sbjct: 472 L 472
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 68.9 bits (167), Expect = 1e-11
Identities = 105/566 (18%), Positives = 237/566 (41%), Gaps = 38/566 (6%)
Query: 61 LDQKGQEVGLLR----QKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMK 116
+D E+ +L+ QKL + + + +YE +++ L+ + + + L ++
Sbjct: 229 IDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIY 288
Query: 117 QNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSE 176
+ + + L K E ++ L K+++ K + + + L+ +++ + E
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 177 KCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
+C + + Q + KQ D+ +E R++ E+ + + + +
Sbjct: 349 ECENLKLECSKLQP--SAVKQ--SDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRL 404
Query: 237 IALSR-NKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRI---IEMERLQ 292
+L++ N L ++N KL +++ +++ ++ LS+ K ELQ LL++ E+ +
Sbjct: 405 SSLNQDNSLAEDNLKLKMRIEVLEKE----KSLLSQEKEELQM--SLLKLNNEYEVIKST 458
Query: 293 LHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQL 352
R++ E + + N E SI E E I E+ + + K + I+ QL
Sbjct: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
Query: 353 QQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAAL-LEKQLKMELEIKEKMLAK 411
+ + +S +++ +++D + +HQ E +TK+ + EK ++ E+ + + L K
Sbjct: 519 SKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTK 578
Query: 412 QKVSDMKYKAV----RTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKL-QYENER 466
QK+ D V +++ +++ +L+ E++ + + R+ + L Q N
Sbjct: 579 QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSN 638
Query: 467 LRNDLAK-LHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPP 525
++ L K ++ N + E+ + V+ E+L CE R +
Sbjct: 639 FKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLA 698
Query: 526 STFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKL-----LNTH 580
Q + +V + + ++ A + L E K K +E+L LNT
Sbjct: 699 GNNQLSLEKNTIV---ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTS 755
Query: 581 IDELQRHTEFTLN-----KYSKLKQN 601
+L+ LN + ++LK+N
Sbjct: 756 ALQLEHEHLIKLNQKKDMEIAELKKN 781
Score = 61.2 bits (147), Expect = 3e-09
Identities = 85/444 (19%), Positives = 203/444 (45%), Gaps = 47/444 (10%)
Query: 15 EAELQELMEQIDIMVSNKKMD--WERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLR 72
+ L +L + +++ S D + ++ L L+ ++QEL +Q E L
Sbjct: 442 QMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQEL-------NQSISEKETLI 494
Query: 73 QKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTN-------------NFEKLRLHQMKQNK 119
+++ L++ N T++ + +K Q SK N N EK R+HQ++ +K
Sbjct: 495 AEIEELDRQNQEATKH----MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDK 550
Query: 120 VP-RKELPHLKEEI---PFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLS 175
+ KEL KE++ L++L+ ++ K Q Q +S+ + L
Sbjct: 551 MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELK 610
Query: 176 EKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIP-RLICDPDPNCEINERDEFIIEKLKSAV 234
E Q +++ + +L + +DS+S L+ + + +++ +E+L +
Sbjct: 611 EHIRQNEEELSRIRNEL--MQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
Query: 235 NEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLH 294
++A ++ EN+KL+ + + Q + AG +++ E ++ ++ ++ME+ ++
Sbjct: 669 KKVAFD---VKMENEKLVLACEDVRHQLEECLAGNNQLSLE---KNTIVETLKMEKGEIE 722
Query: 295 RELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEK--ELNKIRSQL 352
EL + + NK L + + +L + N +K E+ +++ +
Sbjct: 723 AELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNI 782
Query: 353 QQVEEYHNSEQERMRNEISD---LTEELHQKEITIATVTKKAALLEKQL-KMELEIKEKM 408
+Q++ H ++ + + + + LT+ +++KEI I + ++++ L+++L K +++
Sbjct: 783 EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE 842
Query: 409 LAKQKV--SDMKYKAVRTENTHLK 430
+ +Q + D +++ EN HL+
Sbjct: 843 ILRQTIEEKDRSLGSMKEENNHLQ 866
Score = 58.9 bits (141), Expect = 1e-08
Identities = 95/409 (23%), Positives = 175/409 (42%), Gaps = 54/409 (13%)
Query: 16 AELQELMEQIDIMV-------SNKKMDWERKMRALE---TRLDLRDQELANAQTCLDQKG 65
A+LQE + Q+ V S ++D+ +++ E T+L QELA Q + Q
Sbjct: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Query: 66 QEVGLLRQKLD----SLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVP 121
LL KLD L +L Q+ E L+A S++ + +L ++++ +
Sbjct: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAE----CLRASKSEVLSESSELLQQELEELRKS 1355
Query: 122 RKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQF 181
+E K+ L N +L + A + E +++E QT D++ K L EK +
Sbjct: 1356 LQE----KDATIRTLQENNHRLSDSIAATSELERKEH-EQT-----DSEIKQLKEKQDVL 1405
Query: 182 QKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSR 241
QK + + K L S+ + + NE + LK + + +
Sbjct: 1406 QKLLKEKDLLIKAKSDQLLSSNENFTNKVNE-------NELLRQAVTNLKERILILEMDI 1458
Query: 242 NKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEM-ERLQLHRELLKI 300
KL+ EN+K+++ + + + QA++ + +K + R+ M E+ +LLK
Sbjct: 1459 GKLKGENEKIVETYRGKETEYQALQE--TNMKFSMMLREKEFECHSMKEKALAFEQLLK- 1515
Query: 301 GECQNAQGNKTRLESSYLPSIKEPERKI----KELFSVMQDQPNHEKELNKIRSQLQQVE 356
+ QG KT + L ++K + K +E VM + E +++++Q++
Sbjct: 1516 ---EKEQG-KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR 1571
Query: 357 EYH---NSEQERMRNEI----SDLTEELHQKEITIATVTKKAALLEKQL 398
+ N E ER+RN + T E E A + KK +LE++L
Sbjct: 1572 DKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL 1620
Score = 57.4 bits (137), Expect = 4e-08
Identities = 125/642 (19%), Positives = 251/642 (39%), Gaps = 95/642 (14%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ E+ EL + I+ M ++ K + +LE + L Q + + +++ + L+++
Sbjct: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLT-QLINKKEIFIEKLKERSSKLQEE 830
Query: 75 LDSLEKC---NLAMTQNYEGQ---LQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHL 128
LD + N + Q E + L S+K + + L E+LR Q + V +
Sbjct: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS 890
Query: 129 KEEIPFELSNLN-------------------------QKLEEFRAKSREWDKQEILYQTH 163
E+ E+S LN Q L+ + + +E D E YQ
Sbjct: 891 VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD--EFRYQHE 948
Query: 164 LISLDAQQKLL--SEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCE--- 218
++ Q L E+ QK + +TQL+ ++Q ++ +S+I + N E
Sbjct: 949 QMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGS 1008
Query: 219 -----INERDEFIIEKLKSAVNEIALSRNK-----------LQDENQKLLQELKMYQRQC 262
E +++ +K EI L K +DE KL Q ++ +
Sbjct: 1009 EKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEI 1068
Query: 263 QAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIK 322
QA+ A +S S ++D + +++ + RE K+ N KTR E+S+L +
Sbjct: 1069 QALHARIS---STSHTQDVVYLQQQLQAYAMERE--KVFAVLN---EKTR-ENSHLKT-- 1117
Query: 323 EPERKIKELFSVMQDQPNHEKELNKIRSQLQQVE-EYHNSEQERMRNEISDLTEELHQKE 381
E +M E L K++ + +++ + +S Q+ R I +L+ + +K+
Sbjct: 1118 -------EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKD 1170
Query: 382 ITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEY 441
I I +++K + +LA + S +A + + ++ + D +
Sbjct: 1171 IEIDALSQKC--------------QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216
Query: 442 MSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIK 501
+Q T++ +Q+E+ +L+ +L +L N + + QS
Sbjct: 1217 QVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS--- 1273
Query: 502 VEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQH 561
EQNE +L + + + + S Q L+ D+ S +A+
Sbjct: 1274 YEQNETKLKNFGQ----ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAEC 1329
Query: 562 FLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQNRH 603
+ + E +LL ++EL++ + L++N H
Sbjct: 1330 LRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNH 1371
Score = 35.0 bits (79), Expect = 0.20
Identities = 32/148 (21%), Positives = 66/148 (44%), Gaps = 9/148 (6%)
Query: 324 PERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEIT 383
P+ + KE+ ++ + + L K+ + L EE H + + +++ + + +L QKE+
Sbjct: 50 PDSRTKEIEAIHAILRSENERLKKLCTDL---EEKHEASEIQIKQQSTSYRNQLQQKEVE 106
Query: 384 IATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMS 443
I+ + + L+ QL +K + A+ S A ++ G+
Sbjct: 107 ISHLKARQIALQDQL-----LKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDD 161
Query: 444 MDFTNREQSRHTSINKLQYENERLRNDL 471
MDF + S+ IN+L E RL +++
Sbjct: 162 MDFGDIISSQQ-EINRLSNEVSRLESEV 188
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 68.6 bits (166), Expect = 2e-11
Identities = 113/612 (18%), Positives = 260/612 (42%), Gaps = 58/612 (9%)
Query: 33 KMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDS-LEKCNLAMTQNYEG 91
K D + +++ LE L + + ++ + Q L++ L S N +T+ +
Sbjct: 472 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD 531
Query: 92 QLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPH-----------LKEEIPF---ELS 137
QL+ LK ++ + KLR +Q+KQN++ +E L++E+ E
Sbjct: 532 QLKDLKVKYEGASAEVGKLR-NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
Query: 138 NLNQKLEEFRAKSREWDKQEIL------YQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQ 191
+K+ E +++E + L ++ SL + ++K + +++ + ++
Sbjct: 591 KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 650
Query: 192 LNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKL 251
+ K+ LE+ +++ + + P+ + ++ R E +L + E+ L LQ E +K+
Sbjct: 651 IRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 709
Query: 252 LQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKT 311
+ K+ + Q + + L+ +D+ + + L+R+LL + Q K
Sbjct: 710 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV--TQKYTEKKL 767
Query: 312 RLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRS-------QLQQVEEYHNSEQE 364
+E L + + + L +V HEKE+ ++S QL ++++ +QE
Sbjct: 768 EMEKLLLEN-DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
Query: 365 RMR---NEISDLTEELHQKEITIATVTK-KAALLEKQLKMELEIKEKMLAKQKVSDM--K 418
++ +E ++L + + + + + T + K L + K E+ + K+K D+ +
Sbjct: 827 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD---VKKKFEDINQE 883
Query: 419 YKAVRTENTHLKGMMGDLD---PGEYMSM-DFTNREQSRHTSINKLQYENERL------- 467
+ ++ +N LK + + EY+S+ + + S S+ K+Q N +
Sbjct: 884 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 943
Query: 468 RNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPST 527
+ ++ LH K+ +T +E + Y + E+ E + + + +
Sbjct: 944 QEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY 1003
Query: 528 FQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRH 587
++E ++D L + L + L+E ++ E+E+ L+ DEL +
Sbjct: 1004 SVSEEEVKKNKQEND--KLKKEIFTLQKDLRDKTVLIE---KSHEMERALSRKTDELNKQ 1058
Query: 588 TEFTLNKYSKLK 599
+ KY+++K
Sbjct: 1059 LKDLSQKYTEVK 1070
Score = 66.2 bits (160), Expect = 8e-11
Identities = 90/456 (19%), Positives = 194/456 (42%), Gaps = 67/456 (14%)
Query: 94 QSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREW 153
+S K KL N H++ + K E +KE+ ++ L L++ + + E
Sbjct: 441 ESAKQDRLKLQNELA----HKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYES 496
Query: 154 DKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP 213
+ + QTH ++L ++ L SE + + + + QL K E +S+E+ +L
Sbjct: 497 EGKVKQMQTHFLAL--KEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKL---- 550
Query: 214 DPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVK 273
+I +++E I+E+ K KL +EN++L +EL M + + + ++E++
Sbjct: 551 --RNQI-KQNEMIVEEFKR-------DEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 600
Query: 274 SELQSRDDLLRI-IEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELF 332
+ + L + I E+ + ++SS + E +K+ E+
Sbjct: 601 GQAKELSAKLALSIPAEKFE-------------------NMKSSLSNEVNEKAKKLVEM- 640
Query: 333 SVMQDQPNHEKELNKIRSQLQQVE--------EYHNSEQERMRNEISDLTEELHQKEITI 384
+ HEK L++IR +++E E E++++ + + EL +K I
Sbjct: 641 -----EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK---I 692
Query: 385 ATVTKKAALLEKQLKMELEIKEKMLAKQK---VSDMK--YKAVRTENTHLKGMMGDLDPG 439
+T K L+K+++ ++ + K+L +Q +MK Y ++ K +D
Sbjct: 693 TELTLKNQTLQKEIE-KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 751
Query: 440 EYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQ 499
+D T + + + KL EN+ L D+++L ++ + +E+ +
Sbjct: 752 NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL----ETVFVPPEKHEKEIIALKSNI 807
Query: 500 IKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTS 535
+++++ L C ++ + L K+M S
Sbjct: 808 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 843
Score = 51.6 bits (122), Expect = 2e-06
Identities = 127/670 (18%), Positives = 257/670 (38%), Gaps = 146/670 (21%)
Query: 37 ERKMRALETRL--DLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQ 94
+R++ ++ +L ++ +E ++ L+QK E+G +K+ L N Q
Sbjct: 655 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG---KKITELTLKN-----------Q 700
Query: 95 SLKAQFSK--LTNNFEKLRLH----QMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRA 148
+L+ + K L N K + H +MK + VP K +K+ + +LN+KL +
Sbjct: 701 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 760
Query: 149 KSRE-------------------------------WDKQEILYQTHLISLDAQQKLLSEK 177
K E +K+ I +++++ L Q L +K
Sbjct: 761 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 820
Query: 178 CNQFQKQAQSYQTQLNGKKQC-----------------LEDSSSEIPRLICDPDPNCE-- 218
C + Q++ + ++ K+ L D+ ++ R + D E
Sbjct: 821 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 880
Query: 219 ------INERDEFIIEKLKSAVNEI-----------------ALSRNKLQDENQKLLQEL 255
I +++E + L++ N+I + S K+QD N ++L
Sbjct: 881 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY 940
Query: 256 KMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNA-QGNKTRLE 314
+ Q + + A + K EL + + +++ + ++ EC+ + + L+
Sbjct: 941 RKGQEEIVTLHAEIKAQKKELDTIQECIKV-------KYAPIVSFEECERKFKATEKELK 993
Query: 315 SSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQ----VEEYHNSEQ--ERMRN 368
++ +E+ Q+ +KE+ ++ L+ +E+ H E+ R +
Sbjct: 994 DQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1053
Query: 369 EISDLTEELHQKEITIATVTKKAALLEKQLKMELEI--KEKMLAKQKVSDMKYKAVRTEN 426
E++ ++L QK + V +K L+E+ K EI + +L KQ V + +A++
Sbjct: 1054 ELNKQLKDLSQKYTEVKNVKEK--LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKS- 1110
Query: 427 THLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTW---- 482
L G + +L +EQ T +++L EN++ + H+ K +
Sbjct: 1111 --LNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-LENQKNSSVPLAEHLQIKEAFEKEV 1167
Query: 483 ------------TNQNTYEETGRYAYQSQIK-----VEQNEERLSHDCEPNRSTMPPLPP 525
+QN EE + QS+++ +++ E R D ++T L
Sbjct: 1168 GIIKASLREKEEESQNKMEEVSK--LQSEVQNTKQALKKLETREVVDLSKYKATKSDLET 1225
Query: 526 STFQAKEMTSPLVSD-----DDVFPLSPPDMSFPASLAAQHFLLEEE-KRAKELEKLLNT 579
E + L ++V ++S HF +E+E K KE T
Sbjct: 1226 QISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLT 1285
Query: 580 HIDELQRHTE 589
I ELQR +
Sbjct: 1286 TITELQRRIQ 1295
Score = 43.9 bits (102), Expect = 4e-04
Identities = 86/439 (19%), Positives = 177/439 (40%), Gaps = 75/439 (17%)
Query: 236 EIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSR--DDLLRIIEMERL-- 291
E++L EN+ L +EL+ + C++ + ++++EL + + +E ER+
Sbjct: 414 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE 473
Query: 292 -------QLHRELLKIGECQNAQGNKTRLESSYLPSIKE---------PERKIKELFSVM 335
QL L + + K + ++ ++KE R +EL +
Sbjct: 474 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 533
Query: 336 QD----QPNHEKELNKIRSQLQQ----VEEYHN------SEQERMRNEISDLTEELHQKE 381
+D E+ K+R+Q++Q VEE+ E +R++ E+S E +K
Sbjct: 534 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
Query: 382 ITIATVTKKAALLEKQLKMELEIKE----KMLAKQKVSDMKYKAVRTENTHLKG------ 431
+ + +A L +L + + ++ K +V++ K V E H K
Sbjct: 594 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQ 653
Query: 432 -----------MMGDLDPGEYMSMDFTNREQSRH--TSINKLQYENERLRNDLAKLHVNG 478
+ + P E+ + ++S I +L +N+ L+ ++ K++++
Sbjct: 654 LKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 713
Query: 479 K--STWTNQNTYEETGRYAYQSQIKVEQNEERLSHDC---EPNRSTMPPLPPSTFQAKEM 533
K + T E Y +KV ++ ++ SHD + NR + T + EM
Sbjct: 714 KLLKEQAHNLTIEMKNHYV---PLKVSEDMKK-SHDAIIDDLNRKLLDVTQKYTEKKLEM 769
Query: 534 TSPLVSDD----DVFPLS----PPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQ 585
L+ +D DV L PP+ +A + ++E +K+ EL+K +++
Sbjct: 770 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 829
Query: 586 RHTEFTLNKYSKLKQNRHI 604
T N K+ N+++
Sbjct: 830 ALTSENTN-LKKMMSNQYV 847
Score = 42.7 bits (99), Expect = 0.001
Identities = 58/298 (19%), Positives = 128/298 (42%), Gaps = 56/298 (18%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQN------YE 90
E ++L ++ +EL + Q C +++ Q V L Q L++ + ++ + ++ +E
Sbjct: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1164
Query: 91 GQLQSLKAQF----SKLTNNFEKL-RLHQMKQN------KVPRKELPHL------KEEIP 133
++ +KA + N E++ +L QN K+ +E+ L K ++
Sbjct: 1165 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
Query: 134 FELSNLNQKL------------EEFRAKSRE---WDKQEILYQTHLISLDAQQKLLSEKC 178
++S+LN+KL E AK +E D++E+L+ S++ + K E+C
Sbjct: 1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH----FSIEQEIKDQKERC 1280
Query: 179 NQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIA 238
++ Q ++ + +E ++I L+ D +E+LK A+N ++
Sbjct: 1281 DKSLTTITELQRRIQESAKQIEAKDNKITELLND--------------VERLKQALNGLS 1326
Query: 239 LSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ ++ Q + Q Q +++E L++ + Q + R + Q H +
Sbjct: 1327 QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMD 1384
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 68.6 bits (166), Expect = 2e-11
Identities = 113/612 (18%), Positives = 260/612 (42%), Gaps = 58/612 (9%)
Query: 33 KMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDS-LEKCNLAMTQNYEG 91
K D + +++ LE L + + ++ + Q L++ L S N +T+ +
Sbjct: 485 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD 544
Query: 92 QLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPH-----------LKEEIPF---ELS 137
QL+ LK ++ + KLR +Q+KQN++ +E L++E+ E
Sbjct: 545 QLKDLKVKYEGASAEVGKLR-NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
Query: 138 NLNQKLEEFRAKSREWDKQEIL------YQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQ 191
+K+ E +++E + L ++ SL + ++K + +++ + ++
Sbjct: 604 KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 663
Query: 192 LNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKL 251
+ K+ LE+ +++ + + P+ + ++ R E +L + E+ L LQ E +K+
Sbjct: 664 IRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Query: 252 LQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKT 311
+ K+ + Q + + L+ +D+ + + L+R+LL + Q K
Sbjct: 723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV--TQKYTEKKL 780
Query: 312 RLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRS-------QLQQVEEYHNSEQE 364
+E L + + + L +V HEKE+ ++S QL ++++ +QE
Sbjct: 781 EMEKLLLEN-DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 365 RMR---NEISDLTEELHQKEITIATVTK-KAALLEKQLKMELEIKEKMLAKQKVSDM--K 418
++ +E ++L + + + + + T + K L + K E+ + K+K D+ +
Sbjct: 840 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD---VKKKFEDINQE 896
Query: 419 YKAVRTENTHLKGMMGDLD---PGEYMSM-DFTNREQSRHTSINKLQYENERL------- 467
+ ++ +N LK + + EY+S+ + + S S+ K+Q N +
Sbjct: 897 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 956
Query: 468 RNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPST 527
+ ++ LH K+ +T +E + Y + E+ E + + + +
Sbjct: 957 QEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY 1016
Query: 528 FQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRH 587
++E ++D L + L + L+E ++ E+E+ L+ DEL +
Sbjct: 1017 SVSEEEVKKNKQEND--KLKKEIFTLQKDLRDKTVLIE---KSHEMERALSRKTDELNKQ 1071
Query: 588 TEFTLNKYSKLK 599
+ KY+++K
Sbjct: 1072 LKDLSQKYTEVK 1083
Score = 66.2 bits (160), Expect = 8e-11
Identities = 90/456 (19%), Positives = 194/456 (42%), Gaps = 67/456 (14%)
Query: 94 QSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREW 153
+S K KL N H++ + K E +KE+ ++ L L++ + + E
Sbjct: 454 ESAKQDRLKLQNELA----HKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYES 509
Query: 154 DKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDP 213
+ + QTH ++L ++ L SE + + + + QL K E +S+E+ +L
Sbjct: 510 EGKVKQMQTHFLAL--KEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKL---- 563
Query: 214 DPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVK 273
+I +++E I+E+ K KL +EN++L +EL M + + + ++E++
Sbjct: 564 --RNQI-KQNEMIVEEFKR-------DEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 613
Query: 274 SELQSRDDLLRI-IEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELF 332
+ + L + I E+ + ++SS + E +K+ E+
Sbjct: 614 GQAKELSAKLALSIPAEKFE-------------------NMKSSLSNEVNEKAKKLVEM- 653
Query: 333 SVMQDQPNHEKELNKIRSQLQQVE--------EYHNSEQERMRNEISDLTEELHQKEITI 384
+ HEK L++IR +++E E E++++ + + EL +K I
Sbjct: 654 -----EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK---I 705
Query: 385 ATVTKKAALLEKQLKMELEIKEKMLAKQK---VSDMK--YKAVRTENTHLKGMMGDLDPG 439
+T K L+K+++ ++ + K+L +Q +MK Y ++ K +D
Sbjct: 706 TELTLKNQTLQKEIE-KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 764
Query: 440 EYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQ 499
+D T + + + KL EN+ L D+++L ++ + +E+ +
Sbjct: 765 NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL----ETVFVPPEKHEKEIIALKSNI 820
Query: 500 IKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTS 535
+++++ L C ++ + L K+M S
Sbjct: 821 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 856
Score = 51.6 bits (122), Expect = 2e-06
Identities = 127/670 (18%), Positives = 257/670 (38%), Gaps = 146/670 (21%)
Query: 37 ERKMRALETRL--DLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQ 94
+R++ ++ +L ++ +E ++ L+QK E+G +K+ L N Q
Sbjct: 668 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG---KKITELTLKN-----------Q 713
Query: 95 SLKAQFSK--LTNNFEKLRLH----QMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRA 148
+L+ + K L N K + H +MK + VP K +K+ + +LN+KL +
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 773
Query: 149 KSRE-------------------------------WDKQEILYQTHLISLDAQQKLLSEK 177
K E +K+ I +++++ L Q L +K
Sbjct: 774 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 833
Query: 178 CNQFQKQAQSYQTQLNGKKQC-----------------LEDSSSEIPRLICDPDPNCE-- 218
C + Q++ + ++ K+ L D+ ++ R + D E
Sbjct: 834 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 893
Query: 219 ------INERDEFIIEKLKSAVNEI-----------------ALSRNKLQDENQKLLQEL 255
I +++E + L++ N+I + S K+QD N ++L
Sbjct: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY 953
Query: 256 KMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNA-QGNKTRLE 314
+ Q + + A + K EL + + +++ + ++ EC+ + + L+
Sbjct: 954 RKGQEEIVTLHAEIKAQKKELDTIQECIKV-------KYAPIVSFEECERKFKATEKELK 1006
Query: 315 SSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQ----VEEYHNSEQ--ERMRN 368
++ +E+ Q+ +KE+ ++ L+ +E+ H E+ R +
Sbjct: 1007 DQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1066
Query: 369 EISDLTEELHQKEITIATVTKKAALLEKQLKMELEI--KEKMLAKQKVSDMKYKAVRTEN 426
E++ ++L QK + V +K L+E+ K EI + +L KQ V + +A++
Sbjct: 1067 ELNKQLKDLSQKYTEVKNVKEK--LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKS- 1123
Query: 427 THLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTW---- 482
L G + +L +EQ T +++L EN++ + H+ K +
Sbjct: 1124 --LNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-LENQKNSSVPLAEHLQIKEAFEKEV 1180
Query: 483 ------------TNQNTYEETGRYAYQSQIK-----VEQNEERLSHDCEPNRSTMPPLPP 525
+QN EE + QS+++ +++ E R D ++T L
Sbjct: 1181 GIIKASLREKEEESQNKMEEVSK--LQSEVQNTKQALKKLETREVVDLSKYKATKSDLET 1238
Query: 526 STFQAKEMTSPLVSD-----DDVFPLSPPDMSFPASLAAQHFLLEEE-KRAKELEKLLNT 579
E + L ++V ++S HF +E+E K KE T
Sbjct: 1239 QISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLT 1298
Query: 580 HIDELQRHTE 589
I ELQR +
Sbjct: 1299 TITELQRRIQ 1308
Score = 43.9 bits (102), Expect = 4e-04
Identities = 86/439 (19%), Positives = 177/439 (40%), Gaps = 75/439 (17%)
Query: 236 EIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSR--DDLLRIIEMERL-- 291
E++L EN+ L +EL+ + C++ + ++++EL + + +E ER+
Sbjct: 427 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE 486
Query: 292 -------QLHRELLKIGECQNAQGNKTRLESSYLPSIKE---------PERKIKELFSVM 335
QL L + + K + ++ ++KE R +EL +
Sbjct: 487 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 546
Query: 336 QD----QPNHEKELNKIRSQLQQ----VEEYHN------SEQERMRNEISDLTEELHQKE 381
+D E+ K+R+Q++Q VEE+ E +R++ E+S E +K
Sbjct: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
Query: 382 ITIATVTKKAALLEKQLKMELEIKE----KMLAKQKVSDMKYKAVRTENTHLKG------ 431
+ + +A L +L + + ++ K +V++ K V E H K
Sbjct: 607 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQ 666
Query: 432 -----------MMGDLDPGEYMSMDFTNREQSRH--TSINKLQYENERLRNDLAKLHVNG 478
+ + P E+ + ++S I +L +N+ L+ ++ K++++
Sbjct: 667 LKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 726
Query: 479 K--STWTNQNTYEETGRYAYQSQIKVEQNEERLSHDC---EPNRSTMPPLPPSTFQAKEM 533
K + T E Y +KV ++ ++ SHD + NR + T + EM
Sbjct: 727 KLLKEQAHNLTIEMKNHYV---PLKVSEDMKK-SHDAIIDDLNRKLLDVTQKYTEKKLEM 782
Query: 534 TSPLVSDD----DVFPLS----PPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQ 585
L+ +D DV L PP+ +A + ++E +K+ EL+K +++
Sbjct: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
Query: 586 RHTEFTLNKYSKLKQNRHI 604
T N K+ N+++
Sbjct: 843 ALTSENTN-LKKMMSNQYV 860
Score = 42.7 bits (99), Expect = 0.001
Identities = 58/298 (19%), Positives = 128/298 (42%), Gaps = 56/298 (18%)
Query: 37 ERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQN------YE 90
E ++L ++ +EL + Q C +++ Q V L Q L++ + ++ + ++ +E
Sbjct: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1177
Query: 91 GQLQSLKAQF----SKLTNNFEKL-RLHQMKQN------KVPRKELPHL------KEEIP 133
++ +KA + N E++ +L QN K+ +E+ L K ++
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 134 FELSNLNQKL------------EEFRAKSRE---WDKQEILYQTHLISLDAQQKLLSEKC 178
++S+LN+KL E AK +E D++E+L+ S++ + K E+C
Sbjct: 1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH----FSIEQEIKDQKERC 1293
Query: 179 NQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIA 238
++ Q ++ + +E ++I L+ D +E+LK A+N ++
Sbjct: 1294 DKSLTTITELQRRIQESAKQIEAKDNKITELLND--------------VERLKQALNGLS 1339
Query: 239 LSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
+ ++ Q + Q Q +++E L++ + Q + R + Q H +
Sbjct: 1340 QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMD 1397
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 68.6 bits (166), Expect = 2e-11
Identities = 112/572 (19%), Positives = 242/572 (42%), Gaps = 77/572 (13%)
Query: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
+++ E+ L++KL++ + +T+N + QL K Q TN L L+ + K
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN----LHLNTKELLKN 896
Query: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEI------LYQTHLISLDAQQKLL 174
+KE+ LK+ + + + + K + +K+++ L QT D +++L
Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
Query: 175 SEKCN--QFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKS 232
+ N Q+Q S + LN +KQ E+ I + E EF + L+
Sbjct: 957 TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI---------EVRLKESAEFQTQ-LEK 1006
Query: 233 AVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQ---SRDDLLRIIEME 289
+ E+ + +LQD+ ++ ++ + ++Q ++ LS V++E+Q R E +
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESM---EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 290 RLQLHRELLKIG-ECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKI 348
+ +E KI E QN + L ++ + +++ + ++ ++ SV Q + E+ K
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQ---HLEETTQKA 1120
Query: 349 RSQLQQVEEYHNSEQERMRNEIS-------DLTEELHQKEITIATVTKKAALLEK---QL 398
SQL + + + +++E+S DL ++ I ++ K K Q
Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
Query: 399 KMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSIN 458
+ + + E+ +++++ ++ + +R E + + + S+ + R + +
Sbjct: 1181 PLNVSLSEEGKSQEQILEI-LRFIRREKEIAETR---FEVAQVESLRYRQRVELLERELQ 1236
Query: 459 KLQYENERLRNDLAKLHVNGKSTWTNQNTYE--ETGRYAYQSQIKVEQNEERLSHDCEPN 516
+LQ + L + K+ V K+ ++ + ET ++ + + +ERL D +
Sbjct: 1237 ELQ---DSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQ-- 1291
Query: 517 RSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELE-- 574
QAK L D+ PL + A L+ + +L+ EK+ E +
Sbjct: 1292 ----------QMQAKVRKLEL----DILPLQEAN----AELSEKSGMLQAEKKLLEEDVK 1333
Query: 575 --KLLNTHIDELQRHTEFTLNKYSKLKQNRHI 604
K N H+ Q+ + +Y KL + +
Sbjct: 1334 RWKARNQHLVSQQKDPD--TEEYRKLLSEKEV 1363
Score = 60.1 bits (144), Expect = 6e-09
Identities = 101/504 (20%), Positives = 219/504 (43%), Gaps = 78/504 (15%)
Query: 3 NQAHNTMGTSPCEAE-LQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCL 61
N + TS E Q ++ ++ ++ +K E + +E RL +E A QT L
Sbjct: 949 NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL----KESAEFQTQL 1004
Query: 62 DQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKL--RLHQMKQNK 119
++K EV +Q+L ++ + ++ E QL LK S + N ++ R N+
Sbjct: 1005 EKKLMEVEKEKQELQDDKRRAI---ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 120 VPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCN 179
+ + +I E N +++++ +L+ + +L A ++ +S+ +
Sbjct: 1062 QQARRDCQEQAKIAVEAQN-------------KYERELMLHAADVEALQAAKEQVSKMAS 1108
Query: 180 ---QFQKQAQSYQTQLNGKKQCLEDSS----SEIPRLICDPDP----NCEINERDEFIIE 228
++ Q ++QL K E+ E+ + +C + N ++++ E + +
Sbjct: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
Query: 229 KLKSAVNE-----IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLL 283
K+ ++V E + +S ++ +++L+ L+ +R E ++E + E+ + L
Sbjct: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR-----EKEIAETRFEVAQVESLR 1223
Query: 284 RIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEK 343
+E L+ REL ++ + NA+ K ++ + + +E +K + + VM+ +
Sbjct: 1224 YRQRVELLE--RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE 1281
Query: 344 ELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELE 403
E ++ LQQ++ ++ ++ +I L E A +++K+ +L+
Sbjct: 1282 EKERLEQDLQQMQ----AKVRKLELDILPLQE-------ANAELSEKSGMLQ-------- 1322
Query: 404 IKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTS-INKLQY 462
A++K+ + K + N HL D D EY + E+ HT I +L
Sbjct: 1323 ------AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL---LSEKEVHTKRIQQLTE 1373
Query: 463 ENERLRNDLAKLHVNGKSTWTNQN 486
E RL+ ++A+ + S NQN
Sbjct: 1374 EIGRLKAEIAR---SNASLTNNQN 1394
Score = 50.8 bits (120), Expect = 4e-06
Identities = 72/377 (19%), Positives = 163/377 (43%), Gaps = 56/377 (14%)
Query: 97 KAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLE---EFRAKSREW 153
KA +L FE + + + K+ ++L L+E++ +L + N K+ +F +K E
Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT-DLRSQNTKISTQLDFASKRYEM 727
Query: 154 DKQEIL-YQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+ + Y+ + SL + + L+ + ++ + L G + L + L +
Sbjct: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
Query: 213 PD----PNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKM-YQRQCQAMEA 267
+ ++++ E ++ + + N + + +Q ++ E K Q + +E
Sbjct: 788 KEMLKLSEVRLSQQRESLLAEQRGQ-NLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 268 GLSEVK----SELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKE 323
+S +K +E++ R L R ++++ L R+L +T L + +K
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL----------DTETNLHLNTKELLKN 896
Query: 324 PERKI---KELFSVMQ-------------DQPNHEKELNKIRSQLQQVEEYHNSEQERMR 367
+++I K+ S M+ QP+++++++ + SQL+Q EE N +ER++
Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
Query: 368 NE----------ISDLTEELHQKEITIATVTKKAAL-----LEKQLKMELEIKEKMLAKQ 412
++ L E L++++ V K + E Q ++E ++ E KQ
Sbjct: 957 TSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQ 1016
Query: 413 KVSDMKYKAVRTENTHL 429
++ D K +A+ + L
Sbjct: 1017 ELQDDKRRAIESMEQQL 1033
Score = 47.4 bits (111), Expect = 4e-05
Identities = 59/302 (19%), Positives = 126/302 (41%), Gaps = 22/302 (7%)
Query: 3 NQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLD 62
NQ + P E ++L+ + ++ + E R L+ + + L N Q +
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR-LKAEIARSNASLTNNQNLIQ 1397
Query: 63 QKGQEVGLLRQKLDSLEK---CNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNK 119
+++ +R + ++++K + Q + +K + +E+L+ Q K +
Sbjct: 1398 SLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVME 1457
Query: 120 VPRKEL-PHLKEEIPF-ELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEK 177
+ H ++ + E+ L + L + KS+ + Q ++ QK LSEK
Sbjct: 1458 TSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ----------VENLQKTLSEK 1507
Query: 178 ---CNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAV 234
Q+Q Q++L+ +Q L+D +++ +L E E+ I KS +
Sbjct: 1508 ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL---RQQITEKEEKTRKAIVAAKSKI 1564
Query: 235 NEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLH 294
+A +++L EN++L Q +Q ++ ++ +KS+ + R L E + H
Sbjct: 1565 AHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERH 1624
Query: 295 RE 296
E
Sbjct: 1625 LE 1626
Score = 47.0 bits (110), Expect = 5e-05
Identities = 88/419 (21%), Positives = 169/419 (40%), Gaps = 53/419 (12%)
Query: 38 RKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLK 97
R+ ETR ++ E + Q V LL ++L L+ A + + +++
Sbjct: 1205 REKEIAETRFEVAQVESLRYR-------QRVELLERELQELQDSLNAEREKVQVTAKTM- 1256
Query: 98 AQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQE 157
AQ +L E + + M+ NK+ R+E KE + +L + K+ + +
Sbjct: 1257 AQHEELMKKTETMNV-VMETNKMLREE----KERLEQDLQQMQAKVRKLELDILPLQEAN 1311
Query: 158 ILYQTHLISLDAQQKLLSEKCNQFQKQAQ------------SYQTQLNGKK---QCLEDS 202
L A++KLL E +++ + Q Y+ L+ K+ + ++
Sbjct: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
Query: 203 SSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQ-DENQKLLQELKMYQRQ 261
+ EI RL + + ++ +I+ LK +N++ + +Q D + K++ + +
Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI 1431
Query: 262 CQAMEAG--LSEVKSELQSRDDLLRIIEMERLQLHREL-LKIGECQNAQGNKTRLESSYL 318
Q + G EL+++ D + + H+E + + E Q + + E+
Sbjct: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS- 1490
Query: 319 PSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELH 378
K E +++ L + ++ + L + QLQ SE R+R ++ D T
Sbjct: 1491 ---KSLESQVENLQKTLSEKETEARNLQEQTVQLQ-------SELSRLRQDLQDRTT--- 1537
Query: 379 QKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLD 437
Q+E +T+K EK K + K K+ V D K EN LK G LD
Sbjct: 1538 QEEQLRQQITEKE---EKTRKAIVAAKSKIAHLAGVKDQLTK----ENEELKQRNGALD 1589
Score = 41.2 bits (95), Expect = 0.003
Identities = 72/375 (19%), Positives = 150/375 (40%), Gaps = 39/375 (10%)
Query: 232 SAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERL 291
+AV + L R +L + + +L+ + Q+ GL + + + + E+E+
Sbjct: 2 AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQ-QYFEIEKR 60
Query: 292 QLHRELLKIGECQNAQGNKTRLE--SSYLPSIKEPERKIK----ELFSVMQDQPNHEKEL 345
H + + E + Q + LE ++ L ++ E ++++ ++ ++EL
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 346 NKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIK 405
+ L + E + E E + ++ L E+L + T + K L+ + ++ +
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-DVSVKYR 179
Query: 406 EKMLAKQKVSDMKYKAVRTENTHLKGMMGDL-----DPGEYM-----SMDFTNREQSR-H 454
EK L ++K ++ + NT LK +L + G + +++ E SR
Sbjct: 180 EKRLEQEK--ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
Query: 455 TSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCE 514
+N L+ NE L+ + L K Q + EE + IK+ + + D E
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 515 PNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELE 574
+ + +A E L+ + + A+ A Q LLE E+ ++E
Sbjct: 298 AKSNELT-------RAVEELHKLLKE-----------AGEANKAIQDHLLEVEQSKDQME 339
Query: 575 KLLNTHIDELQRHTE 589
K + I L++ E
Sbjct: 340 KEMLEKIGRLEKELE 354
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 68.2 bits (165), Expect = 2e-11
Identities = 119/582 (20%), Positives = 247/582 (42%), Gaps = 69/582 (11%)
Query: 17 ELQELMEQIDIMVS-NKKMDWE-RKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
E+ ME+ I+ NK + E +K++ L + +D + + C+ +K +++ + +
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-VEQMEKCIQEKDEKLKTVEEL 750
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPR--KELPHLKEEI 132
L++ L E +L +++ + S LT + L+ Q Q +EL + E
Sbjct: 751 LET----GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
Query: 133 PFELSNLNQKLEE--FRAKSREWDKQEILYQTHLISLD--------AQQKLLSEKCNQFQ 182
++ ++ + LE + ++E Q++ + + + AQQ ++ K + Q
Sbjct: 807 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQ 866
Query: 183 KQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIA---L 239
+ + Q+N K LE+ ++ E N E LK+ V E+A L
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN-------ESLKAHVQEVAQHNL 919
Query: 240 SRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLK 299
+ ++L LK + + + +EA L E +S+L S+ LL+ ++ E ++ +
Sbjct: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
Query: 300 IGECQNAQGNKTRLESSYLPSIKEPERKIKELFS---VMQDQPNHEKELNKIRSQLQQVE 356
+ + Q + L I E E++I L++ ++D H+++ N R QQVE
Sbjct: 980 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQ--QQVE 1037
Query: 357 EYHNSEQERMRNEISDLT--------EELH-----QKEITIATV-TKKAALLEKQLK--- 399
+E ++ ++ E LH KE T +++ +LE +LK
Sbjct: 1038 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1097
Query: 400 -------MELEIKEKMLAK-QKVSDMKYKAVRTENTHLKGMMGDLDPG-EYMSMDFTNRE 450
+E E + +LA+ + + ++V E K + + + M FT+ E
Sbjct: 1098 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1157
Query: 451 Q------SRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQ 504
Q S + I L+ E E L +L K + +ST+ + + ++++ EQ
Sbjct: 1158 QELERLRSENKDIENLRREREHLEMELEKAEME-RSTYVTEVRELKAQLNETLTKLRTEQ 1216
Query: 505 NE-ERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFP 545
NE ++++ D + ++ + +A T+ ++ + DV P
Sbjct: 1217 NERQKVAGDLHKAQQSLELIQSKIVKAAGDTT-VIENSDVSP 1257
Score = 60.8 bits (146), Expect = 3e-09
Identities = 81/422 (19%), Positives = 177/422 (41%), Gaps = 34/422 (8%)
Query: 66 QEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKEL 125
QE G+LR D++ + +L L+ +++L N + + +++Q +V +K
Sbjct: 424 QENGILR---DAVSNTTNQLESKQSAELNKLRQDYARLVNELTE-KTGKLQQEEVQKKNA 479
Query: 126 PHLKEEIPFELSNLNQKLEE----FRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQF 181
++ +L ++ EE R ++ E + + Q+ ++ + + + L K
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDT 539
Query: 182 QKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIAL-- 239
Q + +L Q +E + + +I E++E + +++ ++IA
Sbjct: 540 LVSKQQLEQRL---MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
Query: 240 SRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLK 299
S + L +E K++ E +Q + E L+ + L S+++ L+ I+ L E+ K
Sbjct: 597 SASVLAEELHKVIAEK---DKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQK 653
Query: 300 IGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYH 359
+ N Q S+ + KI+ L +Q + +++ E KI
Sbjct: 654 LQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKIL---------- 703
Query: 360 NSEQERMRNEISDL---TEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSD 416
N + + +++E+ L E K++ + + K +++LK E+ E L + +
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDV-VEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
Query: 417 MKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSR----HTSINKLQYENERLRNDLA 472
+ A+RTEN+ L + DL + + F + + H K++ E L +L
Sbjct: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 473 KL 474
K+
Sbjct: 823 KV 824
Score = 59.7 bits (143), Expect = 8e-09
Identities = 128/619 (20%), Positives = 244/619 (39%), Gaps = 130/619 (21%)
Query: 15 EAELQELMEQI-DIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQ 73
E E+Q L ++ D +VS ++++ +R M+ +E+ +Q+ N + L + Q++ +
Sbjct: 526 ENEVQSLHSKLTDTLVSKQQLE-QRLMQLMES-----EQKRVNKEESLQMQVQDILEQNE 579
Query: 74 KLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPH------ 127
L A Q + Q+ + + S L K+ + KQ K L
Sbjct: 580 ALK-------AQIQQFHSQIAA-QTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLT 631
Query: 128 LKEEIPFELSNLN-------QKLE----EFRAKSREWDKQEILYQTHLISLDAQQKLLSE 176
KEE ++ N+N QKL+ E A + E +K Q + D + +LL E
Sbjct: 632 SKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKM----QQSVYVKDDKIRLLEE 687
Query: 177 KCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCE--------INERDE---F 225
+ LN + + L+ ++ L+ + PN + I E+DE
Sbjct: 688 QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-QPNKDVVEQMEKCIQEKDEKLKT 746
Query: 226 IIEKLKSAVNEIALSR---NKLQDENQKL---LQELKMYQRQCQAMEAGLSEVKSELQSR 279
+ E L++ + ++A N ++ EN L +Q+LK Q + + + E+K + +
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
Query: 280 DDLLRIIEMERLQLHRELLKIGECQNA-------------QGNKTRLESSYLPSIKEPER 326
D ++ +E L ELLK+ + + +LE + SI +
Sbjct: 807 DGKIKSVEE---LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863
Query: 327 KIKELFSVMQDQPN--------HEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELH 378
+++ L ++Q N EK+L LQ ++E E E ++ + ++ + +
Sbjct: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQE----ENESLKAHVQEVAQH-N 918
Query: 379 QKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKA-----VRTENTHLKGMM 433
KE + A+ ++ ++ K+ + EL+ E ML K++ SD+ K V+ EN K +
Sbjct: 919 LKEASSASQFEELEIVLKEKENELKRLEAML-KERESDLSSKTQLLQDVQDENKLFKSQI 977
Query: 434 GDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGR 493
L Y + I++ + E L N+L L
Sbjct: 978 EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL------------------- 1018
Query: 494 YAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSF 553
++ + H + N + +AKE+ L P +S
Sbjct: 1019 ------------KDAVEHQRKKNNERQQQVEAVELEAKEVLKKLF----------PKVSV 1056
Query: 554 PASLAAQHFLLEEEKRAKE 572
P++L+ +L EK+AKE
Sbjct: 1057 PSNLSYGEWLHGFEKKAKE 1075
Score = 46.2 bits (108), Expect = 9e-05
Identities = 65/335 (19%), Positives = 127/335 (37%), Gaps = 52/335 (15%)
Query: 221 ERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRD 280
ER +I ++K + + N Q++ QE + Q + Q + + + L+ +
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 281 DLLR-IIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQP 339
+LR + QL + Q+A+ NK R + Y + E K +L +
Sbjct: 427 GILRDAVSNTTNQLESK-------QSAELNKLRQD--YARLVNELTEKTGKLQQEEVQKK 477
Query: 340 NHEKELNKIRSQLQQVEEYHNSEQERMRNEIS-------DLTEELHQKEITIATVTKKAA 392
N E+ +++ QLQ+ E Q +R + DL + KE + ++ K
Sbjct: 478 NAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT 537
Query: 393 -------LLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKG-------------- 431
LE++L +E ++K + K++ M+ + + +N LK
Sbjct: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
Query: 432 ----------MMGDLDPGEYMSMDFTNREQSRHTS----INKLQYENERLRNDLAKLHVN 477
++ + D + D E+ R TS + +Q N L+ ++ KL
Sbjct: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
Query: 478 GKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHD 512
+ E+ + Y K+ EE+L H+
Sbjct: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE 692
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 67.8 bits (164), Expect = 3e-11
Identities = 118/603 (19%), Positives = 255/603 (42%), Gaps = 78/603 (12%)
Query: 19 QELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSL 78
QE +++++ NK R LE RL + +Q L Q ++ L +L
Sbjct: 1391 QEFEDKLEVEQQNK--------RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 79 EKCNLAMTQNYEGQLQSLKAQF-SKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELS 137
K +L Q +L+ + +F S+L+ E+ + ++++ K+ R+ K+ + E
Sbjct: 1443 -KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-----KDMLLAEAF 1496
Query: 138 NLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQ 197
+L Q+LEE + ++ + + L + +Q+ + +KQ + + ++ +++
Sbjct: 1497 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEE 1556
Query: 198 CLEDSSSEIP-------RLICDPD-----PNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
L++ + I RL + + + E+ RDE + E +S ++ +L+
Sbjct: 1557 ELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLE 1616
Query: 246 DE---NQKLLQELKMYQRQCQAMEAGLSEV--KSELQSRDDLLRIIEMERLQLHRELLKI 300
+E QK+L+E +R+ + A LS+ + + +S L + ++ + L L +
Sbjct: 1617 EEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLML 1672
Query: 301 GECQNAQGNKTRL--------ESSY-----LPSIKEPERKIKELFSVMQDQPNHEKELNK 347
+N+ +K + ES + + + K E +I++L + D K
Sbjct: 1673 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD---IAKAKTA 1729
Query: 348 IRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEK 407
+ QL +++ N Q R+ + D+ E + + + +A ++ A + ++ +++E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIN---DLQAQLEEA 1786
Query: 408 MLAKQKVSDMKYKAVRTENTHLKGMMGD---LDPGEYMSMDFTNREQSRHTSINKLQYEN 464
KQ++ + K +A++++ L+ M D + E + R + T + +L+
Sbjct: 1787 NKEKQELQE-KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 465 ERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLP 524
RL+ ++ KL T E R A +++ K EQN +RL + M L
Sbjct: 1846 SRLKENMEKL------------TEERDQRIAAENREK-EQN-KRLQRQLRDTKEEMGELA 1891
Query: 525 PSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHF-----LLEEEKRAKELEKLLNT 579
+A L D + + + LA + +E+E + E E L+N+
Sbjct: 1892 RKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINS 1951
Query: 580 HID 582
D
Sbjct: 1952 EGD 1954
Score = 56.6 bits (135), Expect = 6e-08
Identities = 116/521 (22%), Positives = 218/521 (41%), Gaps = 61/521 (11%)
Query: 18 LQELMEQIDIMVSNKKMDWERKMRALET--RLDLRDQELANAQTCLDQKGQEVGLLRQKL 75
++EL+E +D+ S+ M R T RL+ + E + L Q L RQ
Sbjct: 1149 VEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHF 1208
Query: 76 DSLEKCNLAMT---QNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK--ELPHLKE 130
+ +LA+ +N + + KL L Q+ + ++ K E+ L+
Sbjct: 1209 KKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRS 1268
Query: 131 EIPFELSNLNQ-KLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQF--QKQAQS 187
++ N+ +L R +SR + L A Q L +E + +K+ +
Sbjct: 1269 KLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKE 1328
Query: 188 YQTQLNGKKQCLEDSSSEI--PRLICDPDPNCEINERDEFIIEKLK--SAVNEIALSRNK 243
QTQ + K+ +E E+ RLI + N E+++ D +LK AV E+ ++ +
Sbjct: 1329 LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKR 1388
Query: 244 LQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGEC 303
LQ E + +L++ Q+ + +E L +++++ + L+ ++ + +L EL
Sbjct: 1389 LQQEFE---DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL------ 1439
Query: 304 QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKI-RSQLQQVEEYHNSE 362
Q K LE + + E E+K + S + Q + E + K+ R +LQ+ E
Sbjct: 1440 ---QDTKLHLEGQQVRN-HELEKKQRRFDSEL-SQAHEEAQREKLQREKLQR-------E 1487
Query: 363 QERMRNEISDLTEELHQKEITIATVTKKAALLEKQLK---MELEIKEKMLAKQKVSDMKY 419
++ + E L ++L +K++ IA T+K LE +L+ + E LAK K
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVK------ 1541
Query: 420 KAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGK 479
K +R +K +LD + Q + +L+ E ER+R +K
Sbjct: 1542 KQLRDLEAKVKDQEEELD-------EQAGTIQMLEQAKLRLEMEMERMRQTHSK------ 1588
Query: 480 STWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTM 520
++ EE Q K++Q E +L + E + +
Sbjct: 1589 ---EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVL 1626
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 67.8 bits (164), Expect = 3e-11
Identities = 118/608 (19%), Positives = 258/608 (42%), Gaps = 78/608 (12%)
Query: 19 QELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSL 78
QE +++++ NK R LE RL + +Q L Q ++ L +L
Sbjct: 1391 QEFEDKLEVEQQNK--------RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 79 EKCNLAMTQNYEGQLQSLKAQF-SKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELS 137
K +L Q +L+ + +F S+L+ E+ + ++++ K+ R+ K+ + E
Sbjct: 1443 -KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-----KDMLLAEAF 1496
Query: 138 NLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQ 197
+L Q+LEE + ++ + + L + +Q+ + +KQ + + ++ +++
Sbjct: 1497 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEE 1556
Query: 198 CLEDSSSEIP-------RLICDPD-----PNCEINERDEFIIEKLKSAVNEIALSRNKLQ 245
L++ + I RL + + + E+ RDE + E +S ++ +L+
Sbjct: 1557 ELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLE 1616
Query: 246 DE---NQKLLQELKMYQRQCQAMEAGLSEV--KSELQSRDDLLRIIEMERLQLHRELLKI 300
+E QK+L+E +R+ + A LS+ + + +S L + ++ + L L +
Sbjct: 1617 EEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLML 1672
Query: 301 GECQNAQGNKTRL--------ESSY-----LPSIKEPERKIKELFSVMQDQPNHEKELNK 347
+N+ +K + ES + + + K E +I++L + D K
Sbjct: 1673 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD---IAKAKTA 1729
Query: 348 IRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEK 407
+ QL +++ N Q R+ + D+ E + + + +A ++ A + ++ +++E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIN---DLQAQLEEA 1786
Query: 408 MLAKQKVSDMKYKAVRTENTHLKGMMGD---LDPGEYMSMDFTNREQSRHTSINKLQYEN 464
KQ++ + K +A++++ L+ M D + E + R + T + +L+
Sbjct: 1787 NKEKQELQE-KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 465 ERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLP 524
RL+ ++ KL T E R A +++ K EQN +RL + M L
Sbjct: 1846 SRLKENMEKL------------TEERDQRIAAENREK-EQN-KRLQRQLRDTKEEMGELA 1891
Query: 525 PSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHF-----LLEEEKRAKELEKLLNT 579
+A L D + + + LA + +E+E + E E L+N+
Sbjct: 1892 RKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINS 1951
Query: 580 HIDELQRH 587
D + ++
Sbjct: 1952 LQDMVTKY 1959
Score = 56.6 bits (135), Expect = 6e-08
Identities = 116/521 (22%), Positives = 218/521 (41%), Gaps = 61/521 (11%)
Query: 18 LQELMEQIDIMVSNKKMDWERKMRALET--RLDLRDQELANAQTCLDQKGQEVGLLRQKL 75
++EL+E +D+ S+ M R T RL+ + E + L Q L RQ
Sbjct: 1149 VEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHF 1208
Query: 76 DSLEKCNLAMT---QNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRK--ELPHLKE 130
+ +LA+ +N + + KL L Q+ + ++ K E+ L+
Sbjct: 1209 KKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRS 1268
Query: 131 EIPFELSNLNQ-KLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQF--QKQAQS 187
++ N+ +L R +SR + L A Q L +E + +K+ +
Sbjct: 1269 KLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKE 1328
Query: 188 YQTQLNGKKQCLEDSSSEI--PRLICDPDPNCEINERDEFIIEKLK--SAVNEIALSRNK 243
QTQ + K+ +E E+ RLI + N E+++ D +LK AV E+ ++ +
Sbjct: 1329 LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKR 1388
Query: 244 LQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGEC 303
LQ E + +L++ Q+ + +E L +++++ + L+ ++ + +L EL
Sbjct: 1389 LQQEFE---DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL------ 1439
Query: 304 QNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKI-RSQLQQVEEYHNSE 362
Q K LE + + E E+K + S + Q + E + K+ R +LQ+ E
Sbjct: 1440 ---QDTKLHLEGQQVRN-HELEKKQRRFDSEL-SQAHEEAQREKLQREKLQR-------E 1487
Query: 363 QERMRNEISDLTEELHQKEITIATVTKKAALLEKQLK---MELEIKEKMLAKQKVSDMKY 419
++ + E L ++L +K++ IA T+K LE +L+ + E LAK K
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVK------ 1541
Query: 420 KAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGK 479
K +R +K +LD + Q + +L+ E ER+R +K
Sbjct: 1542 KQLRDLEAKVKDQEEELD-------EQAGTIQMLEQAKLRLEMEMERMRQTHSK------ 1588
Query: 480 STWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTM 520
++ EE Q K++Q E +L + E + +
Sbjct: 1589 ---EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVL 1626
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 67.8 bits (164), Expect = 3e-11
Identities = 93/442 (21%), Positives = 196/442 (44%), Gaps = 56/442 (12%)
Query: 36 WERKMRALETRLDLRDQELANA----QTCLDQKGQEVGLLRQKLDSLEKC--NLAMTQNY 89
++ K++ LET L+ + E +++ Q L+++ + L R + E ++ T++
Sbjct: 1119 YKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDL 1178
Query: 90 EGQLQSLKAQFSKLTNNFEKLR-LHQMKQNK--VPRKELPHLKEEIPFELS-------NL 139
+ LK + ++LTNN + ++ L Q+K+ + R+E LKEE+ + +L
Sbjct: 1179 NVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADL 1238
Query: 140 NQKLEEF---RAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKK 196
+K E++ + K + KQ Q + + + KLL K N+ +K+ +L+ K+
Sbjct: 1239 QRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQ 1298
Query: 197 QCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELK 256
+ ++ ++ N++ E I++ + A ++ + ++D L ++ +
Sbjct: 1299 RTIQQLKEQLN------------NQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQ 1346
Query: 257 MYQRQCQAMEAGLSEVK---SELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRL 313
Q Q +EA L EV+ +EL+ + +E + Q R + + G T L
Sbjct: 1347 TQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQ--RSNKEHENNTDVLGKLTNL 1404
Query: 314 ESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDL 373
+ ++E E+K D+ +E + +Q ++ E N E ++ +
Sbjct: 1405 QDE----LQESEQKYNA------DRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERF 1454
Query: 374 TEELHQKEITIATVTKKAALLEK------QLKMELEIKEKMLAKQKVSD----MKYKAVR 423
++ ++ EI A +T+K + L+K QL LEI+ K L V + K +
Sbjct: 1455 FKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRII 1514
Query: 424 TENTHLKGMMGDLDPGEYMSMD 445
+E + ++ + D+ P S D
Sbjct: 1515 SETSKIETQIMDIKPKRISSAD 1536
Score = 54.3 bits (129), Expect = 3e-07
Identities = 105/518 (20%), Positives = 205/518 (39%), Gaps = 72/518 (13%)
Query: 43 LETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSK 102
+E L +E A + QE+ L +K +L K + NY+ + L Q SK
Sbjct: 854 IENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSK 913
Query: 103 LTNNFEKL--------RLHQMKQNKVPRKELPHLKEEIPFELSNLNQ--KLEEFRAKSRE 152
EK+ + N V + +L H K + L +++Q ++ +
Sbjct: 914 NQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLS 973
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICD 212
+E + L L+S++ +++ Q + + + + + + EI +
Sbjct: 974 NGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1033
Query: 213 PDPNCEINERDEFIIEKLKSAVNEIALSRNKLQD-----------ENQKLLQELK-MYQR 260
E E+ IEKL++ V N+L++ E + L+Q+LK Q
Sbjct: 1034 KSHQIEELEQQ---IEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 1090
Query: 261 QCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQ-GNKTRLESSYLP 319
+ ++ + V ++ +L + + + ++ +EL I E Q + + +LE L
Sbjct: 1091 KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKI-KELETILETQKVECSHSAKLEQDILE 1149
Query: 320 S---IKEPERKIKELFSVMQDQPNHEKELN----KIRSQLQQV----------------- 355
I + ER +KE +QD + K+LN K++ ++ Q+
Sbjct: 1150 KESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEE 1209
Query: 356 EEYHNSEQERMRNEIS-------DLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKM 408
EE + E E+++ E+S +L +L +KE A + +K +KQ+K + M
Sbjct: 1210 EETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVM 1269
Query: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLR 468
+ K+ +K + + +LD + +EQ + + + + ER
Sbjct: 1270 RDEDKLLRIKINELEKKKNQCS---QELDMKQRTIQQL--KEQLNNQKVEEAIQQYERAC 1324
Query: 469 NDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNE 506
D L+V K + T EE Q Q +VEQ++
Sbjct: 1325 KD---LNVKEKIIEDMRMTLEE------QEQTQVEQDQ 1353
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 67.8 bits (164), Expect = 3e-11
Identities = 94/465 (20%), Positives = 200/465 (43%), Gaps = 57/465 (12%)
Query: 15 EAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQK 74
+ EL E E I + ++K++WER++ +L L+ +++ NA T ++ ++ LR+K
Sbjct: 764 QRELSETKE-IKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ---LRRK 819
Query: 75 LDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPF 134
+ K + + Q E LQ+L ++ L +K
Sbjct: 820 EEQYRK-EVEVKQQLELSLQTL------------EMELRTVK------------------ 848
Query: 135 ELSNLNQKLEEFRAKSREWDKQEILYQ------THLISLDAQQKLLSEKCNQFQKQAQSY 188
SNLNQ ++E R+ +++ T+ +S + ++ +K N +
Sbjct: 849 --SNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEE 906
Query: 189 QTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDEN 248
+ L+ K L++ + + RL D N + E+++ E LK + + ++
Sbjct: 907 EKDLSHKNSMLQEEIAML-RLEIDTIKN-QNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE 964
Query: 249 QKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHREL-LKIGECQNAQ 307
+ L Q + Y + + A + + S+L++ +E E H L I + ++
Sbjct: 965 ETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE 1024
Query: 308 GNKTRLESSYLPSIKEPER-KIKELFSVMQDQPNHE---KELNKIRSQLQQVE-EYHNSE 362
+K LE ++ + E R + K F V + N+E ++L K S+L +E E+H++
Sbjct: 1025 TSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHT- 1083
Query: 363 QERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAV 422
R+ + + T L + + ++ + +E++ + E K + KQ+ + + +
Sbjct: 1084 ----RDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQL 1139
Query: 423 RTENTHLKGMMGDL-DPGEYMSMDFTNREQSRHTSINKLQYENER 466
++EN L+ + D + + N + H + KLQ E+E+
Sbjct: 1140 QSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1184
Score = 53.9 bits (128), Expect = 4e-07
Identities = 93/440 (21%), Positives = 172/440 (39%), Gaps = 61/440 (13%)
Query: 17 ELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLD 76
+LQ E+ +++ + + + L+ R + E A + + Q QE+ +K
Sbjct: 1177 KLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK-Q 1235
Query: 77 SLEKCNLAMTQNY----EGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEI 132
S+ + +L +T Y E + Q LK + ++ N ++ + + + K H
Sbjct: 1236 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDH----- 1290
Query: 133 PFELSNLNQKLEEFRAK-----SREWDKQEILYQTHL-ISLDAQQKLLSEKCNQFQKQAQ 186
QKLE+ AK ++ DK E L + L +L +K +K + ++ +
Sbjct: 1291 -------KQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLE 1343
Query: 187 SYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIE-KLKSAVNEIALSRNKLQ 245
Q K LE + L+ E EF LK++ E+ + NKL+
Sbjct: 1344 CNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLK 1403
Query: 246 DENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQN 305
+ L EL+ +C ++ ++ EL S + + +C+
Sbjct: 1404 HKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQK-----------------KCEK 1446
Query: 306 AQGNKTRLESSYLPSIKEPERKIKELFSVMQ-DQPNHEKELNKIRSQLQQVEEY------ 358
Q NK +LE + ER + EL V Q Q E+ +I +L++V +
Sbjct: 1447 LQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAA 1506
Query: 359 --HNSEQERMRN----------EISDLTEELHQKEITIATVTKKAALLEKQLKM-ELEIK 405
N EQ R N I DL EL + + + K KQL + EL+++
Sbjct: 1507 SQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR 1566
Query: 406 EKMLAKQKVSDMKYKAVRTE 425
+ + +K ++ + V T+
Sbjct: 1567 KSLSSKLTKTNERLAEVNTK 1586
Score = 41.6 bits (96), Expect = 0.002
Identities = 93/500 (18%), Positives = 188/500 (37%), Gaps = 64/500 (12%)
Query: 147 RAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLN----GKKQCLEDS 202
+ KS E D Q+ + + + L ++ +K+ ++ + +N GK L
Sbjct: 584 KRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGG 643
Query: 203 SSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQC 262
++ D + ++E DE K NE +NK++++ +Q +
Sbjct: 644 LLQV-------DDDSSLSEIDEDEGRPTKKTSNE----KNKVKNQ----IQSMDDVDDLT 688
Query: 263 QAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE--LLKIGECQNAQGNKTRLESSYLPS 320
Q+ E + + S + + +IE ++ LLKI + + L+ ++
Sbjct: 689 QSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCEL 748
Query: 321 IKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQK 380
+ +K+++ +V+Q + + KE I+SQL+ + E +R ++ E+
Sbjct: 749 LTVKIKKMEDKVNVLQRELSETKE---IKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA 805
Query: 381 EITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGD----- 435
+ + ++ E+Q + E+E+K+++ + +M+ + V++ + D
Sbjct: 806 DTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL 865
Query: 436 --------LDPG------------EYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLH 475
L G E + H L ++N L+ ++A L
Sbjct: 866 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLR 925
Query: 476 VNGKSTWTNQNTYEETGRYAYQSQIK---------VEQNEERLSHDCEPNRSTMPPLPPS 526
+ T NQN +E + +K ++QNEE L+ + L
Sbjct: 926 LE-IDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVL--- 981
Query: 527 TFQAKEMTSPLVSD-DDVFPLSPPDMSFPASLAAQ-HFLLEEEKRAKELEKLLNTHIDEL 584
T + + S L ++ L S+ + LAA H + E +ELE DE
Sbjct: 982 TAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDEC 1041
Query: 585 QRHTEFTLNKYSKLKQNRHI 604
R + S LK N I
Sbjct: 1042 SRLQDKMNFDVSNLKDNNEI 1061
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 67.4 bits (163), Expect = 4e-11
Identities = 125/621 (20%), Positives = 239/621 (38%), Gaps = 101/621 (16%)
Query: 41 RALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQF 100
R LE L +D L + + QK + + LR+K D+ E+ L + + E L K
Sbjct: 1250 RTLEDHLKRKDLSLNDLE---QQKNKLMEELRRKRDNEEEL-LKLIKQMEKDLAFQKQVA 1305
Query: 101 SKLTNNFEKLRL----------HQMKQNKVP----------RKELPHLKEEIPFELSNLN 140
K +K+ L + ++N +P R +E + L
Sbjct: 1306 EKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELK 1365
Query: 141 QKLEEFRAKSR--EWDKQEILYQTHLISLDA-----QQKLLSEKCNQFQKQAQSYQTQLN 193
Q+++E A +R E D +E+ Y+ + + L+ + +LL +K ++ + + +L
Sbjct: 1366 QQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELE 1425
Query: 194 GKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEK--LKSAVNEIALSRNKLQDENQKL 251
K Q + S ++ L N + +E + E LK L L E KL
Sbjct: 1426 RKDQAEKGYSQQLREL--GRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL 1483
Query: 252 LQELKMYQRQCQAMEAGLSEVKSELQS-RDDLLRIIEMERLQL---------------HR 295
+E+ R E + + S++ S RD+ E+ERLQ+ H
Sbjct: 1484 QREVDRITRAHAVAEKNIQHLNSQIHSFRDEK----ELERLQICQRKSDHLKEQFEKSHE 1539
Query: 296 ELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEK-ELNKIRSQLQQ 354
+LL+ + + +K + + L E +K+ + Q N K + +I+++ +
Sbjct: 1540 QLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESEN 1599
Query: 355 VEEYHNSEQER----------MRNEISDLTEELHQKEITIATVTKKAALLEKQL----KM 400
+ + Q+R ++++ E LH++ T +K LE+ L +
Sbjct: 1600 IVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNL 1659
Query: 401 ELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKL 460
E K+K + + K VR N L + GE + Q + + +L
Sbjct: 1660 VSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGE-------QKVQLQQAQVQEL 1712
Query: 461 QYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTM 520
N RL+ +LH+ T EE + ++ + ++ + E R M
Sbjct: 1713 ---NNRLKKVQDELHLK---------TIEE--QMTHRKMVLFQEESGKFKQSAEEFRKKM 1758
Query: 521 PPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLA-AQHFLLEEEKRAKELEKLLNT 579
L M S +++++D+ + +S + AQ E KELE+ L
Sbjct: 1759 EKL---------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQ 1809
Query: 580 HIDELQRHTEFTLNKYSKLKQ 600
+ +++Q+ N Y K ++
Sbjct: 1810 YREQMQQGQHMEANHYQKCQK 1830
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/421 (20%), Positives = 171/421 (40%), Gaps = 81/421 (19%)
Query: 56 NAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEG---------------QLQSLKAQF 100
N Q L+ E G L++++D + + + +N + +LQ + +
Sbjct: 1468 NYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKS 1527
Query: 101 SKLTNNFEKLR---LHQMKQNKVPRKELPHLKEEIPFELSN-----LNQKLEEFRAKSRE 152
L FEK L +K K ++ L EE+ E SN L QK+EE ++ E
Sbjct: 1528 DHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL--EKSNECAEMLKQKVEELTRQNNE 1585
Query: 153 WDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNG-----------------K 195
Q ++ +++ + ++C + QA ++ QL K
Sbjct: 1586 TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRK 1645
Query: 196 KQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQEL 255
+CLE+ ++ L+ + C ++ II+ K V + N ++E ++ Q++
Sbjct: 1646 IKCLEEDLAKSQNLVSEFKQKC---DQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKV 1702
Query: 256 KMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLES 315
++ Q Q Q + L +V+ EL + +E HR+++ E ES
Sbjct: 1703 QLQQAQVQELNNRLKKVQDELHLK-------TIEEQMTHRKMVLFQE-----------ES 1744
Query: 316 SYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQE----------R 365
E RK E +M+ + E +++ IR +++ ++ QE
Sbjct: 1745 GKFKQSAEEFRKKME--KLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKE 1802
Query: 366 MRNEISDLTEELHQKEITIATVTKKAALLEKQL---KMELE-IKEKMLAKQKVSDMKYKA 421
+ ++ E++ Q + A +K LE +L K E+E +K+KM Q++ + +++
Sbjct: 1803 LERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM--DQQIKEHEHQL 1860
Query: 422 V 422
V
Sbjct: 1861 V 1861
Score = 38.9 bits (89), Expect = 0.014
Identities = 75/426 (17%), Positives = 186/426 (43%), Gaps = 62/426 (14%)
Query: 141 QKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSE------KCNQFQKQAQSYQTQLNG 194
Q++E + K +E Q +T L+ Q+ L+SE K ++ QK A+ Y +
Sbjct: 981 QQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
Query: 195 KK------QCLEDSSSEIP----RLICDPD----PNCEINERDEFIIEKLKSAVNEIALS 240
+ + + DS + P R+ D ++ R ++ + + S
Sbjct: 1039 YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS 1098
Query: 241 RNKLQDENQKLLQELK-------MYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQL 293
+L++E K +E + QRQ +A S++ ++ + ++ ++ ++ ++
Sbjct: 1099 LKRLEEEEIKRCKETSEHGAYSDLLQRQ-KATVLENSKLTGKISELERMVAELKKQKSRV 1157
Query: 294 HRELLKI-----GECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKI 348
EL K+ E + Q N + + + E ++ +EL ++++++ E+EL ++
Sbjct: 1158 EEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERV 1217
Query: 349 RSQLQQVEEYHNSEQERM---RNEISD-------LTEELHQKEITIATVTKKAALLEKQL 398
R + E + +E + RN++ + L + L +K++++ + ++ L ++L
Sbjct: 1218 RQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEEL 1277
Query: 399 KMELEIKEKM--LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMS-MDFTNREQSRHT 455
+ + + +E++ L KQ D+ ++ E + +L+ ++ + +T RE +
Sbjct: 1278 RRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPV 1337
Query: 456 ----------SINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQ---SQIKV 502
++ LQ E+++ + + K V+ + T N+ ++ Y+ Q++
Sbjct: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVD-ELTAANRKAEQDMRELTYELNALQLEK 1396
Query: 503 EQNEER 508
+EE+
Sbjct: 1397 TSSEEK 1402
Score = 29.6 bits (65), Expect = 8.4
Identities = 32/134 (23%), Positives = 61/134 (45%), Gaps = 12/134 (8%)
Query: 341 HEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKM 400
H++ L+ ++S+ E++ QE SD+T+ +KE+ + K E
Sbjct: 679 HQQVLSNLQSRF---EDFLEDSQESQVFSGSDITQL--EKEVNVC----KQYYQELLKSA 729
Query: 401 ELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKL 460
E E +E+ + +S+++ +R EN + + P + D + R T KL
Sbjct: 730 EREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP---LERDDLHESVFRITEQEKL 786
Query: 461 QYENERLRNDLAKL 474
+ E ERL++DL +
Sbjct: 787 KKELERLKDDLGTI 800
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,634,694
Number of Sequences: 37866
Number of extensions: 976643
Number of successful extensions: 8738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 880
Number of HSP's that attempted gapping in prelim test: 5035
Number of HSP's gapped (non-prelim): 2758
length of query: 604
length of database: 18,247,518
effective HSP length: 108
effective length of query: 496
effective length of database: 14,157,990
effective search space: 7022363040
effective search space used: 7022363040
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.