Guide to the Human Genome
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Search of human proteins with 239745948

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239745948 PREDICTED: hypothetical protein XP_002343622 [Homo
sapiens]
         (791 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239745948 PREDICTED: hypothetical protein XP_002343622 [Homo ...  1664   0.0  
gi|239756943 PREDICTED: hypothetical protein [Homo sapiens]          1640   0.0  
gi|239751443 PREDICTED: hypothetical protein [Homo sapiens]          1640   0.0  
gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo sap...    45   3e-04
gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo sap...    45   3e-04
gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo sapi...    45   3e-04
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    45   3e-04
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          42   0.002
gi|27894378 chloride intracellular channel 6 [Homo sapiens]            41   0.004
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              41   0.005
gi|115392133 collagen, type XXIV, alpha 1 [Homo sapiens]               40   0.008
gi|156616290 collagen type VI alpha 6 [Homo sapiens]                   40   0.011
gi|91208420 bassoon protein [Homo sapiens]                             40   0.011
gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]               40   0.011
gi|154759255 collagen, type XXVIII precursor [Homo sapiens]            40   0.011
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    39   0.014
gi|160707881 formin 2 [Homo sapiens]                                   39   0.019
gi|51172610 Rho guanine nucleotide exchange factor (GEF) 5-like ...    39   0.025
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]       39   0.025
gi|169214011 PREDICTED: hypothetical protein [Homo sapiens]            38   0.032
gi|239756028 PREDICTED: hypothetical protein [Homo sapiens]            38   0.032
gi|113428768 PREDICTED: hypothetical protein [Homo sapiens]            38   0.032
gi|113428351 PREDICTED: hypothetical protein [Homo sapiens]            38   0.032
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      37   0.055
gi|122937233 discs, large (Drosophila) homolog-associated protei...    37   0.071
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               37   0.071
gi|4502081 amphiphysin isoform 1 [Homo sapiens]                        37   0.093
gi|154146231 DMRT-like family A2 [Homo sapiens]                        37   0.093
gi|134031945 SCO-spondin [Homo sapiens]                                37   0.093
gi|60097902 filaggrin [Homo sapiens]                                   36   0.12 

>gi|239745948 PREDICTED: hypothetical protein XP_002343622 [Homo
           sapiens]
          Length = 791

 Score = 1664 bits (4309), Expect = 0.0
 Identities = 791/791 (100%), Positives = 791/791 (100%)

Query: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60
           MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH
Sbjct: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60

Query: 61  QGHLSGLVHTGQQLPIVPATPQPLTQQLRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 120
           QGHLSGLVHTGQQLPIVPATPQPLTQQLRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG
Sbjct: 61  QGHLSGLVHTGQQLPIVPATPQPLTQQLRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 120

Query: 121 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 180
           QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL
Sbjct: 121 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 180

Query: 181 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 240
           LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG
Sbjct: 181 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 240

Query: 241 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 300
           CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA
Sbjct: 241 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 300

Query: 301 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 360
           LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA
Sbjct: 301 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 360

Query: 361 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 420
           DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD
Sbjct: 361 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 420

Query: 421 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 480
           DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA
Sbjct: 421 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 480

Query: 481 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 540
           HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP
Sbjct: 481 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 540

Query: 541 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 600
           GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA
Sbjct: 541 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 600

Query: 601 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 660
           NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA
Sbjct: 601 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 660

Query: 661 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 720
           PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH
Sbjct: 661 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 720

Query: 721 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 780
           TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV
Sbjct: 721 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 780

Query: 781 GCAVLGARSEA 791
           GCAVLGARSEA
Sbjct: 781 GCAVLGARSEA 791


>gi|239756943 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 783

 Score = 1640 bits (4247), Expect = 0.0
 Identities = 783/791 (98%), Positives = 783/791 (98%), Gaps = 8/791 (1%)

Query: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60
           MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH
Sbjct: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60

Query: 61  QGHLSGLVHTGQQLPIVPATPQPLTQQLRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 120
           QGHLSGLVHTGQQLPIVPA        LRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG
Sbjct: 61  QGHLSGLVHTGQQLPIVPA--------LRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 112

Query: 121 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 180
           QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL
Sbjct: 113 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 172

Query: 181 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 240
           LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG
Sbjct: 173 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 232

Query: 241 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 300
           CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA
Sbjct: 233 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 292

Query: 301 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 360
           LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA
Sbjct: 293 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 352

Query: 361 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 420
           DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD
Sbjct: 353 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 412

Query: 421 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 480
           DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA
Sbjct: 413 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 472

Query: 481 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 540
           HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP
Sbjct: 473 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 532

Query: 541 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 600
           GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA
Sbjct: 533 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 592

Query: 601 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 660
           NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA
Sbjct: 593 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 652

Query: 661 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 720
           PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH
Sbjct: 653 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 712

Query: 721 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 780
           TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV
Sbjct: 713 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 772

Query: 781 GCAVLGARSEA 791
           GCAVLGARSEA
Sbjct: 773 GCAVLGARSEA 783


>gi|239751443 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 783

 Score = 1640 bits (4247), Expect = 0.0
 Identities = 783/791 (98%), Positives = 783/791 (98%), Gaps = 8/791 (1%)

Query: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60
           MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH
Sbjct: 1   MSSARRVELALPITWLLAVARGRMMSSGHMAFSHWPAEAGLCSPDVSRGPGEPTYRNFVH 60

Query: 61  QGHLSGLVHTGQQLPIVPATPQPLTQQLRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 120
           QGHLSGLVHTGQQLPIVPA        LRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG
Sbjct: 61  QGHLSGLVHTGQQLPIVPA--------LRKCSVSNFHIPIRPPGPEAKRTHGPSAAFQDG 112

Query: 121 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 180
           QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL
Sbjct: 113 QPPALPVTTGQLPGTERPTCNRLIHGKGLVLHEHALTLLLFQDGLIAHAPGGVHVPLVAL 172

Query: 181 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 240
           LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG
Sbjct: 173 LWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGG 232

Query: 241 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 300
           CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA
Sbjct: 233 CGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVA 292

Query: 301 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 360
           LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA
Sbjct: 293 LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREA 352

Query: 361 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 420
           DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD
Sbjct: 353 DGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQD 412

Query: 421 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 480
           DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA
Sbjct: 413 DGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA 472

Query: 481 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 540
           HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP
Sbjct: 473 HHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGP 532

Query: 541 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 600
           GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA
Sbjct: 533 GWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGA 592

Query: 601 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 660
           NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA
Sbjct: 593 NRAPAALQVRALRLHRNKACPALPAPTHLQAEPTRTFRLVREMGVSGPAGVWVVAVDCHA 652

Query: 661 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 720
           PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH
Sbjct: 653 PACGRAHTHAHSLSGLGLRRGNWCEGAALRTPHRVFQRARLRTRAGLPWRVSLAHVDTPH 712

Query: 721 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 780
           TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV
Sbjct: 713 TEVRLLHARSFSGTSTSHQANLLKLDRRNWEANPGWYLSSPINKRFSGRLPPGLLASRGV 772

Query: 781 GCAVLGARSEA 791
           GCAVLGARSEA
Sbjct: 773 GCAVLGARSEA 783


>gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo
           sapiens]
          Length = 492

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)

Query: 467 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 524
           GP P  Q+  Q+  H  G +       ++   +   DSP  P   S W QL   +     
Sbjct: 273 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 332

Query: 525 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 577
            G EG    RWA   PG  G  A  G Q  PLP  E  PG  G  L R      GP   +
Sbjct: 333 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 388

Query: 578 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 635
              L +R             + ++  P  + V  L L +  A P +P+P  L+A   R  
Sbjct: 389 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 433

Query: 636 -TFRLVREM 643
            T R VR +
Sbjct: 434 QTHRAVRAL 442


>gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo
           sapiens]
          Length = 902

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)

Query: 467 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 524
           GP P  Q+  Q+  H  G +       ++   +   DSP  P   S W QL   +     
Sbjct: 683 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 742

Query: 525 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 577
            G EG    RWA   PG  G  A  G Q  PLP  E  PG  G  L R      GP   +
Sbjct: 743 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 798

Query: 578 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 635
              L +R             + ++  P  + V  L L +  A P +P+P  L+A   R  
Sbjct: 799 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 843

Query: 636 -TFRLVREM 643
            T R VR +
Sbjct: 844 QTHRAVRAL 852


>gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo
           sapiens]
          Length = 433

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)

Query: 467 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 524
           GP P  Q+  Q+  H  G +       ++   +   DSP  P   S W QL   +     
Sbjct: 214 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 273

Query: 525 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 577
            G EG    RWA   PG  G  A  G Q  PLP  E  PG  G  L R      GP   +
Sbjct: 274 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 329

Query: 578 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 635
              L +R             + ++  P  + V  L L +  A P +P+P  L+A   R  
Sbjct: 330 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 374

Query: 636 -TFRLVREM 643
            T R VR +
Sbjct: 375 QTHRAVRAL 383


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 47/230 (20%), Positives = 83/230 (36%), Gaps = 32/230 (13%)

Query: 322  DLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLH 381
            ++ +G+ +   E+    G      +E EG++   +  E +GE   +EE   G G E G  
Sbjct: 818  EVEEGKGEREEEEEEGEGEE----EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEE 873

Query: 382  HTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAP 441
              G+ E EE +G  +EE  G       G   +GE   +++GE +  +      G ++   
Sbjct: 874  GEGEGEEEEGEGEGEEEGEGE------GEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927

Query: 442  RPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALT 501
                  +   +G         +   G    E+EE + +   +G  +G  G          
Sbjct: 928  GEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGE--------- 978

Query: 502  WDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAGTQ 551
                         G+ + + G G G E  G       G G + G   G +
Sbjct: 979  -------------GEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015



 Score = 38.1 bits (87), Expect = 0.032
 Identities = 34/139 (24%), Positives = 54/139 (38%), Gaps = 2/139 (1%)

Query: 347 EVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAP 406
           E EG     +  E +G    KEE     GGEV     G+ E EE +G  +EE    ++  
Sbjct: 788 EEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVE-EGKGEREEEEEEGEGEEEEGEGEEEE 846

Query: 407 FLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGV-EALAAAGWDMA 465
             G   +GE   +++GE   G+        + +        +   +G  E     G    
Sbjct: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906

Query: 466 LGPGPWEQEERQSQAHHQG 484
            G G  E+EE + +   +G
Sbjct: 907 EGEGEGEEEEGEGKGEEEG 925



 Score = 37.4 bits (85), Expect = 0.055
 Identities = 50/228 (21%), Positives = 81/228 (35%), Gaps = 52/228 (22%)

Query: 196  EEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPMLTPALV 255
            EE+EG G   EG+G+                  ++       G G GEE  +        
Sbjct: 829  EEEEGEGEEEEGEGE-----------------EEEGEGEEEEGEGKGEEEGEE------- 864

Query: 256  AATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQ 315
                 G G +EG + +     E  ++   G+G   G G                 +G+++
Sbjct: 865  -----GEGEEEGEEGE----GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915

Query: 316  PLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTG 375
                     +G+ +   E     G       E EG+D   +  E +GE   +EE   G G
Sbjct: 916  ---------EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966

Query: 376  GEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGE 423
             E      G+ E EE +G  +EE     +    G   +GE   +++GE
Sbjct: 967  EE-----EGEGEGEEGEGEGEEE-----EGEGEGEEEEGEEEGEEEGE 1004



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 33/171 (19%), Positives = 69/171 (40%), Gaps = 12/171 (7%)

Query: 324 YQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRG-------TGG 376
           +Q +++   E     G +  PG+  +      + ++ DGE+  ++E  +G          
Sbjct: 669 WQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEME 728

Query: 377 EVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGL 436
           E G    G+ E EE    ++EE  G  +    G   +GE   +++GE K+ + A      
Sbjct: 729 EGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER-EKEEGERKKEERAGKEEKG 787

Query: 437 QDDAPRPRAVTQVV----VQGVEALAAAGWDMALGPGPWEQEERQSQAHHQ 483
           +++  +     +       +  E     G ++  G G  E+EE + +   +
Sbjct: 788 EEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 46/209 (22%), Positives = 78/209 (37%), Gaps = 40/209 (19%)

Query: 196  EEDEGPGIG---GEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPMLTP 252
            EE+EG G G   GEG+G+     G             +     G G G  EE +      
Sbjct: 896  EEEEGEGEGEEEGEGEGEEEEGEG-----------KGEEEGEEGEGEGEEEEGEG----- 939

Query: 253  ALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQG 312
                  +G  G  EG +++     E  +    G+  G G G                 +G
Sbjct: 940  ------EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG---EGEEEEGEGEG 990

Query: 313  DDQPLCIDDDLYQGQQQSHSEDH-PAPGPVVLPGQ---EVEGKDVSRQTREADGEQNPKE 368
            +++     +   +G+++   E+     G     G+   EVEG++   +  E +GE+  +E
Sbjct: 991  EEE-----EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045

Query: 369  EAPRGTGGEVGLHHTGKHEAEEAQGPQKE 397
                G G E   +   + E EE +G  +E
Sbjct: 1046 REKEGEGEE---NRRNREEEEEEEGKYQE 1071



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 52/250 (20%), Positives = 89/250 (35%), Gaps = 43/250 (17%)

Query: 196  EEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPMLTPALV 255
            EE+EG G   EG+G+     G             +     G G   GEE +         
Sbjct: 836  EEEEGEGEEEEGEGEEEEGEG-----------KGEEEGEEGEGEEEGEEGE--------- 875

Query: 256  AATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQ 315
                 G G +E  + +  +  E   +   G+G G   G                 +G+++
Sbjct: 876  -----GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG------EGEEEEGEGKGEEE 924

Query: 316  PLCIDDDLYQGQQQSHSEDHPAPGPVV---LPGQEVEGKDVSRQTREADGEQNPKEEAPR 372
                + +  + + +   ED    G        G+E EG+    +  E +GE+   E    
Sbjct: 925  GEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984

Query: 373  GTGGEVGLHHTGKHEAEE-AQGPQ------KEEYLGPQQAPFLGVLHKGEAGHQDDGEHK 425
               GE G    G+ E EE  +G +      +EE  G  +    G   +GE G +++GE +
Sbjct: 985  EGEGE-GEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGE-GEEEEGEEE 1042

Query: 426  RGDNARPSHG 435
              +  +   G
Sbjct: 1043 GEEREKEGEG 1052


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 123/469 (26%), Positives = 161/469 (34%), Gaps = 96/469 (20%)

Query: 185  LGHLGDLGDDVEEDEGPGIGGEGD-GQRGVI-PGGTVVLLVAVSIHDDPHHPYGNGGGCG 242
            +G  GD GD  E+      G  G  G RG   P G    LV            G  G  G
Sbjct: 1669 VGEKGDQGDPGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTG---PGAREKGEPGDRG 1725

Query: 243  EEH-KDPMLTPALVAAT--------QGGPGPQEGTQQQQHDVDECHDKVHVG-DGTGGGH 292
            +E  + P   P L  A         +G PGPQ G    +    E  D+   G DG  G  
Sbjct: 1726 QEGPRGPKGDPGLPGAPGERGIEGFRGPPGPQ-GDPGVRGPAGEKGDRGPPGLDGRSGLD 1784

Query: 293  GPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKD 352
            G   AA        + PN    +      D   G +       P+ GP  LPG+   G+D
Sbjct: 1785 GKPGAAGP------SGPNGAAGKAGDPGRDGLPGLRGEQGLPGPS-GPPGLPGKP--GED 1835

Query: 353  VSRQTREADGEQ-NPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEE----YLGPQQAPF 407
                    +GE  +P E+  +G  G+     +G    E   GP+ E      LGPQ  P 
Sbjct: 1836 GKPGLNGKNGEPGDPGEDGRKGEKGD-----SGASGREGRDGPKGERGAPGILGPQGPPG 1890

Query: 408  L----------------GVLHKGEAGHQDDGEHKRGDNARPSH-GLQDDAPRPRAVTQVV 450
            L                G   KG+ G        +G+   P   GL+ +      V +++
Sbjct: 1891 LPGPVGPPGQGFPGVPGGTGPKGDRGETGS----KGEQGLPGERGLRGEPGSVPNVDRLL 1946

Query: 451  -VQGVEALA----AAGWDMALGP---------GPWEQEERQSQAHHQGFVD--------- 487
               G++A A       WD + G          GP      Q     +G +          
Sbjct: 1947 ETAGIKASALREIVETWDESSGSFLPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLKG 2006

Query: 488  --GHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGR--GAGRWARPGPGWD 543
              G PG Q    LAL    PP P   +     +P   G  G  GR  G G   RPG   +
Sbjct: 2007 DRGDPGPQGPPGLALGERGPPGPSGLAG----EPGKPGIPGLPGRAGGVGEAGRPGERGE 2062

Query: 544  GGARA-----GTQGLP-LPGTEAEPGALGCSLSRGPVPRQGSLLSARVG 586
             G +      G  G P LPGT   PG  G  +S   V   G  LS   G
Sbjct: 2063 RGEKGERGEQGRDGPPGLPGTPGPPGPPGPKVS---VDEPGPGLSGEQG 2108



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 97/363 (26%), Positives = 129/363 (35%), Gaps = 63/363 (17%)

Query: 234  PYGNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGD----GTG 289
            P G+ G  GE+  DP           G PGP  G + +  +V E  D+   GD    G  
Sbjct: 1605 PPGDSGPPGEKG-DP--------GRPGPPGPV-GPRGRDGEVGEKGDEGPPGDPGLPGKA 1654

Query: 290  GGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSE--DHPAPGPVVLPGQE 347
            G  G    A  +R  +    +QGD       +D   G   S     D   PGP   PG+ 
Sbjct: 1655 GERGLR-GAPGVRGPVGEKGDQGDP-----GEDGRNGSPGSSGPKGDRGEPGPPGPPGRL 1708

Query: 348  VEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHT-GKHEAEEAQGPQKEEYLGPQQAP 406
            V   D     RE     +  +E PRG  G+ GL    G+   E  +GP      GPQ  P
Sbjct: 1709 V---DTGPGAREKGEPGDRGQEGPRGPKGDPGLPGAPGERGIEGFRGPP-----GPQGDP 1760

Query: 407  FLGVLHKGEAGHQDDG-----EHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAG 461
              GV  +G AG + D      + + G + +P  G    +    A  +    G + L    
Sbjct: 1761 --GV--RGPAGEKGDRGPPGLDGRSGLDGKP--GAAGPSGPNGAAGKAGDPGRDGLPGLR 1814

Query: 462  WDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQA 521
             +  L PGP               + G PG   +  L      P  P +    G+     
Sbjct: 1815 GEQGL-PGP----------SGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEKGDSG 1863

Query: 522  GGGRGWEGRGAGRWARPGPGWDGGARAGTQGLPLP------GTEAEPGALGCSLSRGPVP 575
              GR  EGR   +  R  PG  G    G  GLP P      G    PG  G    RG   
Sbjct: 1864 ASGR--EGRDGPKGERGAPGILG--PQGPPGLPGPVGPPGQGFPGVPGGTGPKGDRGETG 1919

Query: 576  RQG 578
             +G
Sbjct: 1920 SKG 1922



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 72/257 (28%), Positives = 89/257 (34%), Gaps = 29/257 (11%)

Query: 336  PAP-GPVVLPGQEVEGKDVSRQTREADGEQ-NPKEEAPRGTGGEVGLHHTGKHEAEEAQG 393
            P P GPV  PG++ E  D         G+  +P E+ PRG  G +G            + 
Sbjct: 1432 PGPQGPVGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEA 1491

Query: 394  PQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSH-GLQDDAPRPRAVTQVVVQ 452
             +K E   P  A   G+   G AG        +G    P   G Q +   P       V 
Sbjct: 1492 GEKGERGPPGPAGSRGL--PGVAGRPG----AKGPEGPPGPTGRQGEKGEPGRPGDPAVV 1545

Query: 453  GVEALAAAGWDMALGP-GPWEQEERQSQAHHQGFV-DGHPGSQARLWLALTWDSPPAPLQ 510
            G       G    +GP GP      Q +    G V  G PG +         D  P  L 
Sbjct: 1546 GPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGPKGD-----PGDRGPIGLT 1600

Query: 511  RSVWGQLQPQAGGGRGWEGRGAGRWARPGP----GWDGGA-RAGTQGLP----LPGTEAE 561
                G+  P    G   E    GR   PGP    G DG     G +G P    LPG   E
Sbjct: 1601 ----GRAGPPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAGE 1656

Query: 562  PGALGCSLSRGPVPRQG 578
             G  G    RGPV  +G
Sbjct: 1657 RGLRGAPGVRGPVGEKG 1673



 Score = 37.4 bits (85), Expect = 0.055
 Identities = 35/113 (30%), Positives = 44/113 (38%), Gaps = 11/113 (9%)

Query: 468  PGPWEQEERQSQAHHQGF--VDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGR 525
            PGP       +    +GF   DG PGS  R        +P  P    + G   P   G R
Sbjct: 1283 PGPQGPPGSATAKGERGFPGADGRPGSPGRA------GNPGTPGAPGLKGS--PGLPGPR 1334

Query: 526  GWEGRGAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQG 578
            G  G    R  +  PG  G    G +G  LPG + +PG  G    RGP+   G
Sbjct: 1335 GDPGERGPRGPKGEPGAPGQVIGG-EGPGLPGRKGDPGPSGPPGPRGPLGDPG 1386



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 64/238 (26%), Positives = 82/238 (34%), Gaps = 61/238 (25%)

Query: 344  PGQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQ 403
            PGQ + G+      R+ D    P    P G  G +G             GP+     GP 
Sbjct: 1352 PGQVIGGEGPGLPGRKGD----PGPSGPPGPRGPLG-----------DPGPR-----GPP 1391

Query: 404  QAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAA-GW 462
              P  G   KG+ G        RG+   P  G    AP           G+  L  + G 
Sbjct: 1392 GLP--GTAMKGDKGD-------RGERGPPGPGEGGIAPGE--------PGLPGLPGSPGP 1434

Query: 463  DMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG 522
               +GP   + E+  S+    G + G PGS            P  P      G + P+  
Sbjct: 1435 QGPVGPPGKKGEKGDSEDGAPG-LPGQPGSPGE-------QGPRGPP-----GAIGPK-- 1479

Query: 523  GGRGWEGR--GAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQG 578
            G RG+ G    AG     GP    G+R       LPG    PGA G     GP  RQG
Sbjct: 1480 GDRGFPGPLGEAGEKGERGPPGPAGSRG------LPGVAGRPGAKGPEGPPGPTGRQG 1531



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 66/261 (25%), Positives = 86/261 (32%), Gaps = 43/261 (16%)

Query: 335  HPAPGPVVLPGQE-VEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQG 393
            H  PGP   PG     G       +   GE  P      G  G VGL             
Sbjct: 2182 HGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGP---------- 2231

Query: 394  PQKEEYLGPQQAPFL----GVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQV 449
            P     +GPQ +P L    G   K  A  +D    K GD   P        P P     V
Sbjct: 2232 PGPSGLVGPQGSPGLPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGP-----V 2286

Query: 450  VVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPL 509
              +G      A     +G  P  + E+ +     G + G PG++    L       P P 
Sbjct: 2287 GPKGEPGPTGAPGQAVVGL-PGAKGEKGAPGGLAGDLVGEPGAKGDRGL-------PGPR 2338

Query: 510  -QRSVWGQL----------QPQAGGGRGWEGR-GAGRWARPGPGWDGGARAGTQGLPLPG 557
             ++   G+           Q  A G +G++G  G G    PGP    G +     L LPG
Sbjct: 2339 GEKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPGPPGVKGD---LGLPG 2395

Query: 558  TEAEPGALGCSLSRGPVPRQG 578
                PG +G     GP    G
Sbjct: 2396 LPGAPGVVGFPGQTGPRGEMG 2416



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 88/333 (26%), Positives = 112/333 (33%), Gaps = 57/333 (17%)

Query: 338  PGPVVLPGQEVEGKDVSRQTREAD-GEQNPK-EEAPRGTGGEVGLHHT-------GKHEA 388
            PG   +PG       V    R  + GE+  K E   +G  G  GL  T       G   +
Sbjct: 2036 PGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPPGPKVS 2095

Query: 389  EEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHK--------RGDNARPSHGLQDDA 440
             +  GP      GP          KGE G   D   K        +GD   P    QD  
Sbjct: 2096 VDEPGPGLSGEQGPPGLKGA----KGEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGN 2151

Query: 441  PR-PRAVTQVVVQGVEALAAA-GWDMALG----PGPWEQEERQSQAHHQG--FVDGHPGS 492
            P  P        +G   L    G    +G    PGP         A  QG   + G PG 
Sbjct: 2152 PGLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEPGE 2211

Query: 493  QARLWLALTWDS-------PPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPG-PGWDG 544
                   LT  +       PP P      G + PQ  G  G  G+  G   +PG PG DG
Sbjct: 2212 TGPPGRGLTGPTGAVGLPGPPGPS-----GLVGPQ--GSPGLPGQ-VGETGKPGAPGRDG 2263

Query: 545  GA-RAGTQGLP-LPGTEAEPGALGCSLSRGPVPRQGSLLSARVGWSLHHRYITSIQGANR 602
             + + G +G P +PG+   PG +G     GP    G    A VG       +   +G   
Sbjct: 2264 ASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPG---QAVVG-------LPGAKGEKG 2313

Query: 603  APAALQVRALRLHRNKACPALPAPTHLQAEPTR 635
            AP  L    +     K    LP P   + E  R
Sbjct: 2314 APGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGR 2346


>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
          Length = 686

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 97/386 (25%), Positives = 128/386 (33%), Gaps = 80/386 (20%)

Query: 212 GVIPGGTVVLLVAVSIHDDPHHPYGNGGGC----GEEHKDPMLTPALVAATQGGPGPQEG 267
           GV PG      V   + + P  P   GG      G E  +     A      GG GP  G
Sbjct: 9   GVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRG 68

Query: 268 TQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQ 327
            + +       H +    +G   G              A  P  G++           G 
Sbjct: 69  PEAEARGTRGAHGETEAEEGAPEG--------------AEVPQGGEET---------SGA 105

Query: 328 QQSHSEDHPAPGPVVLPGQEV--EGKDVSRQTREADGEQNPKEEAPRGT-GGEVGLHHTG 384
           QQ      P  G    P  E   E +D +   R+ + EQ P  E P G+  GE G     
Sbjct: 106 QQVEGAS-PGRGAQGEPRGEAQREPEDSAAPERQEEAEQRP--EVPEGSASGEAG----- 157

Query: 385 KHEAEEAQGPQKE--EYLGP-----QQAPFLG--VLHKGEAGHQDDGEHKRGDNARPSHG 435
             ++ +A+GP  +  E  GP     +    +G  V  +G AG   D E   GDN +    
Sbjct: 158 --DSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGP 215

Query: 436 LQD------------DAPRPRAVTQVVVQG-----VEALAAAGWDMALGPGPWEQEERQS 478
             D            DA  P A   V  +G     VEA   AG  +  G    +  E + 
Sbjct: 216 AGDSVDAEGRVGDSVDAEGP-AGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEG 274

Query: 479 QAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARP 538
            A      +G  G   R+             Q+S  G L PQA       G  AGR   P
Sbjct: 275 PAGDSMDAEGPAGRARRV---------SGEPQQSGDGSLSPQAEAIEVAAGESAGR--SP 323

Query: 539 GP-GWDGGARAGTQGLPLPGTEAEPG 563
           G   WD    A   G+     EA PG
Sbjct: 324 GELAWDAAEEAEVPGVK-GSEEAAPG 348



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 57/234 (24%), Positives = 89/234 (38%), Gaps = 24/234 (10%)

Query: 345 GQEVEGKDVSRQTREADGEQNPKEEA--PRGTGGEVGLHHTGKHEAE-------EAQGP- 394
           G  V+ +  +  + +A+G      EA  P G G E G+      EAE       +A+GP 
Sbjct: 227 GDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPA 286

Query: 395 -QKEEYLG-PQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQ 452
            +     G PQQ+    +  + EA     GE         +    ++A  P         
Sbjct: 287 GRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAA 346

Query: 453 GVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRS 512
             +A A AG D  +G GP +QE  + +   +   +G    +A      + DS  +P   +
Sbjct: 347 PGDARADAGEDR-VGDGP-QQEPGEDEERRERSPEGPREEEAAGGEEESPDS--SPHGEA 402

Query: 513 VWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGALG 566
             G  +P+A        + +   A  GP    G  A   G    G  +EP ALG
Sbjct: 403 SRGAAEPEA--------QLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALG 448



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 73/331 (22%), Positives = 107/331 (32%), Gaps = 65/331 (19%)

Query: 163 DGLIAHAPGGVHVPLVALLWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLL 222
           D + A  P G  V     L   +   G  GD V+ +   G   + +G  G     +V   
Sbjct: 188 DSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAG----DSVDAE 243

Query: 223 VAVSIHDDPHHPYGNGGGCGEEHKDPMLTPALVAATQGGPGPQ------EGTQQQQHD-- 274
             V    +   P G+G   G    D +        +    GP        G  QQ  D  
Sbjct: 244 GRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGS 303

Query: 275 VDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSED 334
           +    + + V  G   G  P   A            +G ++    D     G      ED
Sbjct: 304 LSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAG------ED 357

Query: 335 HPAPGPVVLPGQEVEGKDVS----RQTREADGEQNPKEEAPRG---TGGEVGLHHTGKHE 387
               GP   PG++ E ++ S    R+   A GE+   + +P G    G          H 
Sbjct: 358 RVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHL 417

Query: 388 AEEAQGPQKEEYLGPQQAPFLGVLHKGEA----GHQDDGEHKRGDNARPSHGLQDDAPRP 443
           AEE          GP +         GEA    G ++DGE                A  P
Sbjct: 418 AEE----------GPAEG-------SGEAARVNGRREDGE----------------ASEP 444

Query: 444 RAVTQVVVQGVEALAAAGWD-MALGPGPWEQ 473
           RA+ Q     +     AG+D  ++G  P+ Q
Sbjct: 445 RALGQ--EHDITLFVKAGYDGESIGNCPFSQ 473


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 70/338 (20%), Positives = 118/338 (34%), Gaps = 48/338 (14%)

Query: 262  PGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVAL--RAALATAPNQGDDQPLCI 319
            P  +   Q +  DV+    +  V   + G   P     A     ++     +G+D+P   
Sbjct: 1877 PEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESE 1936

Query: 320  DDDLYQGQQQSH-SEDHPAPGPVVLPGQE-----------VEGKDVSRQTREADGEQNPK 367
              +  + ++ +  +E    P   V+  QE           VE  +V  +T+EA+GE  P+
Sbjct: 1937 GAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPE 1996

Query: 368  E---EAPRGTG-----------GEVGLHHTGKHEAEEAQ----GPQKEEYLGPQQAPFLG 409
                EAP   G              G+    K E EEAQ      QK E     ++  + 
Sbjct: 1997 SEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVE 2056

Query: 410  VLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPG 469
                 E   + +GE +  +          DA       Q   +GVEA  A G        
Sbjct: 2057 APEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116

Query: 470  PWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEG 529
               + E ++Q   +G        +A+               +   G+ QP++    G E 
Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQ-------PESEGVEAQDAEGEAQPES---EGIEA 2166

Query: 530  RGAGRWARP------GPGWDGGARAGTQGLPLPGTEAE 561
            + A   A+P       P  +G A+  ++G+  P  E E
Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 70/319 (21%), Positives = 103/319 (32%), Gaps = 78/319 (24%)

Query: 169  APGGVHVPLVALLWAGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIH 228
            APG  H    +      G  G LG  + +  G   G +G+G +             ++  
Sbjct: 1709 APGKTHTDPTSTRTVQ-GAEGGLGPGLSQGPGVDEGEDGEGSQ------------RLNRD 1755

Query: 229  DDPHHPYGNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGT 288
             DP      G    +E +         A ++ G   QEG        +   ++   G G 
Sbjct: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEG--------EGISERGETG-GQ 1806

Query: 289  GGGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEV 348
            G GH       A  A     P Q D     I+    +G+ Q  SE   AP        E 
Sbjct: 1807 GSGHEDNLQGEAA-AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAP--------EA 1856

Query: 349  EGKDVSRQTREADGEQNPKE---EAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQA 405
            EG       +EA+GE  P+    EAP   G         + E+E+ + P+ E  + P+  
Sbjct: 1857 EG-----DAQEAEGEAQPESEDVEAPEAEG-------EAQPESEDVETPEAEWEVQPE-- 1902

Query: 406  PFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMA 465
                                       S G   +AP      Q   + VEAL   G D  
Sbjct: 1903 ---------------------------SEGA--EAPEAEKEAQPETESVEALETEGEDEP 1933

Query: 466  LGPGPWEQEERQSQAHHQG 484
               G   QE  ++    +G
Sbjct: 1934 ESEGAEAQEAEEAAQEAEG 1952



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 25/109 (22%), Positives = 39/109 (35%), Gaps = 14/109 (12%)

Query: 325  QGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTG 384
            +G +   +E+   P P  +   E EG+       E  GE+    +   G G         
Sbjct: 2210 EGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDG--------Q 2261

Query: 385  KHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPS 433
              EA E+  P  E+   P  +P       G+  HQ  G      ++R S
Sbjct: 2262 SEEASESSSPVPEDRPTPPPSP------GGDTPHQRPGSQTGPSSSRAS 2304


>gi|115392133 collagen, type XXIV, alpha 1 [Homo sapiens]
          Length = 1714

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 71/267 (26%), Positives = 96/267 (35%), Gaps = 53/267 (19%)

Query: 339  GPVVLPGQE-VEGKDVSRQTREADGEQNPKEE-------APRGTGGEVGL----HHTGKH 386
            GPV LPG+  + G    +  R + G   P+ E        P G  G +G      H G  
Sbjct: 855  GPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGAR 914

Query: 387  EAEEAQGPQKEE-YLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRA 445
                +QGP+ +    GP      G+L  GE G Q     K     R  HGL      P  
Sbjct: 915  GPPGSQGPKGQRGSRGPD-----GLL--GEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGE 967

Query: 446  VTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFV--DGHPGSQARLWLALTWD 503
                   G++ L  +  D  L PG       Q      G +  +G PG++    L     
Sbjct: 968  RGFQGKPGLQGLPGSTGDRGL-PGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGL----- 1021

Query: 504  SPPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPG-------PGWDG-GARAGTQGLP- 554
                        Q +P A G  G  G   G    PG       PG +G   + G +G+P 
Sbjct: 1022 ------------QGEPGAKGDVGTAG-SVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPG 1068

Query: 555  ---LPGTEAEPGALGCSLSRGPVPRQG 578
               LPG + E G +G     GP+ R G
Sbjct: 1069 GRGLPGEDGEKGEMGLPGIIGPLGRSG 1095



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 67/273 (24%), Positives = 91/273 (33%), Gaps = 42/273 (15%)

Query: 311  QGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEA 370
            QG++ P+    +L    +         PGP  L G+  +  ++ +            E  
Sbjct: 806  QGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIG----------ETG 855

Query: 371  PRGTGGEVGLHHTGKHEAEEAQ----GPQKEE----YLGPQQAPF-LGVL----HKGEAG 417
            P G  GEVG+  +   + E       GPQ E+    Y GP   P  +G L    H G  G
Sbjct: 856  PVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARG 915

Query: 418  HQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQ 477
                   K    +R   GL  +            QG++       D     GP     + 
Sbjct: 916  PPGSQGPKGQRGSRGPDGLLGE------------QGIQGAKGEKGDQGKR-GPHGLIGKT 962

Query: 478  SQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGR----GWEGRGAG 533
                 +GF  G PG Q           P  P  R + G + P    G     G EG  +G
Sbjct: 963  GNPGERGF-QGKPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGE-SG 1020

Query: 534  RWARPGPGWDGGARAGTQGLPLPGTEAEPGALG 566
                PG   D G      G   PG   EPGA G
Sbjct: 1021 LQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPG 1053


>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
          Length = 2263

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 76/292 (26%), Positives = 104/292 (35%), Gaps = 61/292 (20%)

Query: 285  GDGTGGGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLP 344
            GDGT G  GP       R       ++G           Y G++    E   APGPV   
Sbjct: 1393 GDGTMGDPGPP----GKRGPPGFKGSEG-----------YLGEEGIAGE-RGAPGPVGEQ 1436

Query: 345  GQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQ 404
            G           T+   G + PK    RG  G+ G    G++  +   G Q +  L  ++
Sbjct: 1437 G-----------TKGCYGTKGPKGN--RGLNGQEG--EVGENGIDGLNGEQGDNGLPGRK 1481

Query: 405  APFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAA---- 460
                    KG+ G Q     +     R + GL+ D   P   + +  +G   L       
Sbjct: 1482 G------EKGDEGSQGSPGKRGTPGDRGAKGLRGDPGAPGVDSSI--EGPTGLKGERGRQ 1533

Query: 461  ---GWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVW--G 515
               GW    GP       R++ AH +    GH G Q    +       P  L+ S+   G
Sbjct: 1534 GRRGWP---GPPGTPGSRRKTAAHGRR---GHTGPQGTAGIP-----GPDGLEGSLGLKG 1582

Query: 516  QLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAGTQG-LPLPGTEAEPGALG 566
               P+   G   E  G G     GP   GG  AG QG L   G + EPG LG
Sbjct: 1583 PQGPRGEAGVKGEKGGVGSKGPQGPPGPGG-EAGNQGRLGSQGNKGEPGDLG 1633


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 56/235 (23%), Positives = 76/235 (32%), Gaps = 38/235 (16%)

Query: 369  EAPRGTGGEVGLHHTGKHEAEEAQ--GPQKEEYLGPQQAPFLGVLHKGEAG---HQDDGE 423
            + PR    +   HH G   +  +Q  GP +  Y    + P  G+    E G   H    E
Sbjct: 3585 DKPRDARSDRFRHHGGHAVSSSSQKRGPARHSYHDYDEPPEEGLWPHDEGGPGRHASAKE 3644

Query: 424  HKRGDNARPSHGLQDDAPRPRAV-------------TQVVVQGVEALAAAGWDMALGPGP 470
            H+ GD+ R S     + P  RA                       A+   G         
Sbjct: 3645 HRHGDHGRHSGRHTGEEPGRRAAKPHARDLGRHEARPHSQPSSAPAMPKKGQPGYPSSAE 3704

Query: 471  WEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGR 530
            + Q  R S A+H    D   GS+          S PA LQ     Q QPQ          
Sbjct: 3705 YSQPSRASSAYHHA-SDSKKGSRQA-------HSGPAALQSKAEPQAQPQL--------- 3747

Query: 531  GAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGSLLSARV 585
              GR A PGP         ++ +P      +P         G  P Q +L  AR+
Sbjct: 3748 -QGRQAAPGP--QQSQSPSSRQIPSGAASRQPQTQQQQQGLGLQPPQQALTQARL 3799


>gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]
          Length = 1860

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 68/248 (27%), Positives = 90/248 (36%), Gaps = 53/248 (21%)

Query: 325  QGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQN-PKEEAPRGTGGEVGLHHT 383
            +G++    ED  A GP   PG    G    R  R   G+   P +E  +G  G+ G    
Sbjct: 1326 KGEKGEQGEDGKAEGPPGPPGDR--GPVGDRGDRGEPGDPGYPGQEGVQGLRGKPGQQGQ 1383

Query: 384  GKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRP 443
              H       P    + GP+ +       KG  G +           R   GLQ   P P
Sbjct: 1384 PGH-------PGPRGWPGPKGS-------KGAEGPKGKQGKAGAPGRRGVQGLQG-LPGP 1428

Query: 444  RAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFV--DGHPGSQARLWLALT 501
            R V  V  QG+E +A          GP     R  QA  QG    DG PG          
Sbjct: 1429 RGV--VGRQGLEGIA----------GPDGLPGRDGQAGQQGEQGDDGDPGPMG------- 1469

Query: 502  WDSPPAPLQRSVWGQLQPQAGGGRGWEGRGA--GRWARPGPGWDGGARAGTQGLP-LPGT 558
                PA  + +      P A G  G++G     G+   PG       + GT+G   LPG 
Sbjct: 1470 ----PAGKRGNPGVAGLPGAQGPPGFKGESGLPGQLGPPG-------KRGTEGRTGLPGN 1518

Query: 559  EAEPGALG 566
            + EPG+ G
Sbjct: 1519 QGEPGSKG 1526



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 65/247 (26%), Positives = 87/247 (35%), Gaps = 56/247 (22%)

Query: 366  PKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEY-LGPQQAPFLGVLHKGEAGHQDDGEH 424
            P +  P G  G+ G    G        GP+ +E  +GP  AP L    +G+ G       
Sbjct: 918  PGDNGPEGMKGKPGAR--GLPGPRGQLGPEGDEGPMGPPGAPGL----EGQPG------- 964

Query: 425  KRGDNARPS----HGLQDDAPRPRAVTQ------VVVQGVEALAAAGWDMALGPGPWEQE 474
            ++G   RP      G   D  RP  V +      + + G   +     D  +   P    
Sbjct: 965  RKGFPGRPGLDGVKGEPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPPGVPG 1024

Query: 475  ERQSQAHHQGF-----VDGHPGSQARLWLALTWDSPPA----PLQRSVWGQLQPQ----- 520
             + S  H  G        G PG Q           PP     P  R   G+  P+     
Sbjct: 1025 PKGSMGH-PGMPGGMGTPGEPGPQG----------PPGSRGPPGMRGAKGRRGPRGPDGP 1073

Query: 521  AG--GGRGWEGRGA--GRWARPGPGWDGGARA--GTQGLP-LPGTEAEPGALGCSLSRGP 573
            AG  G RG +G     GR  RPG     G R   G++G P +PG    PG  G     GP
Sbjct: 1074 AGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGPSGPPGTKGLPGEPGP 1133

Query: 574  VPRQGSL 580
               QG +
Sbjct: 1134 QGPQGPI 1140



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 95/362 (26%), Positives = 124/362 (34%), Gaps = 70/362 (19%)

Query: 236  GNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGP- 294
            G  G  GE+    M+ P  V   +G  G               H  +  G GT G  GP 
Sbjct: 1003 GEPGIVGEKGDRGMMGPPGVPGPKGSMG---------------HPGMPGGMGTPGEPGPQ 1047

Query: 295  ----ACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPG----Q 346
                +     +R A      +G D P         G+Q S     P PGP   PG    Q
Sbjct: 1048 GPPGSRGPPGMRGAKGRRGPRGPDGPA--------GEQGSRGLKGP-PGPQGRPGRPGQQ 1098

Query: 347  EVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAP 406
             V G+     +R   G   P    P GT G  G    G    +   GP  E  +GP+  P
Sbjct: 1099 GVAGERGHLGSRGFPGIPGPS--GPPGTKGLPG--EPGPQGPQGPIGPPGE--MGPKGPP 1152

Query: 407  FLGVLHK----GEAGHQDDGEHKRGDNARPSH-GLQDDAPRPRAVTQVVVQGVEALAAAG 461
              G + +    GEAG + D     G    P   GL      P         G + L    
Sbjct: 1153 --GAVGEPGLPGEAGMKGD----LGPLGTPGEQGLIGQRGEPGLEGDSGPMGPDGLKGDR 1206

Query: 462  WDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQA 521
             D    PGP  +   + Q    G  DG PG        +T    P         + +  A
Sbjct: 1207 GD----PGPDGEHGEKGQEGLMG-EDGPPGPPG-----VTGVRGPEGKSGKQGEKGRTGA 1256

Query: 522  GGGRGWEGRGAGRWARPG----PGWDG--GARA--GTQGLP-LPGTEAEPGALGCSLSRG 572
             G +G++G+  G    PG    PG  G  G+R   G  G P   G + EPG  G    +G
Sbjct: 1257 KGAKGYQGQ-LGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKG 1315

Query: 573  PV 574
             V
Sbjct: 1316 IV 1317



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 7/69 (10%)

Query: 516 QLQPQAGGGRGWEGRGAGRWARPGPGWDGGARA--GTQGLP----LPGTEAEPGALGCSL 569
           Q QP   G  G +G   GR   PGP  D G +   G  GLP    LPG++ E G  G   
Sbjct: 723 QGQPGPEGSPGAKGY-PGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPG 781

Query: 570 SRGPVPRQG 578
            RG +   G
Sbjct: 782 KRGKMGMPG 790


>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
          Length = 1125

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 64/231 (27%), Positives = 85/231 (36%), Gaps = 69/231 (29%)

Query: 365 NPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDG-- 422
           +P +  P GT G  G+           +G +     GP+  P  G   KGEAG +  G  
Sbjct: 246 DPGDPGPPGTHGNPGI-----------KGER-----GPKGNP--GNAQKGEAGERGPGGI 287

Query: 423 ------EHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEER 476
                 + +RG+  +P  G++ D   P        +G++ +     D    PGP      
Sbjct: 288 PGYKGDKGERGECGKP--GIKGDKGSPGPYGPKGPRGIQGITGPPGD----PGP------ 335

Query: 477 QSQAHHQGFVD--GHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGR---- 530
                 +GF    G PG          + SP AP      G  Q    G RG EGR    
Sbjct: 336 ------KGFQGNKGEPGPPG------PYGSPGAP------GIGQQGIKGERGQEGRPGAP 377

Query: 531 ---GAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQG 578
              G G   +PGP    G   G +GLP    E  PG  G   S GP   QG
Sbjct: 378 GPIGVGEPGQPGPRGPEGV-PGERGLP---GEGFPGPKGEKGSEGPTGPQG 424


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 43/181 (23%), Positives = 64/181 (35%), Gaps = 20/181 (11%)

Query: 304 ALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGE 363
           +L     Q +++     D+  Q +  S  E+HPA         E    + S       GE
Sbjct: 158 SLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPA---------ETNQNEGSESGTIRQGE 208

Query: 364 QNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGE 423
           + P EE     G    L H  + +  E QG Q+  + G       G L +        GE
Sbjct: 209 ELPPEELQESQG----LLHPQEVQVLEEQGQQEAGFRGE------GTLREDVCADGLLGE 258

Query: 424 HKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQ 483
            +  +      G Q           +  QG E +   G    L  G WEQE+ + +A  Q
Sbjct: 259 EQMIEQVNDEKGEQKQKQEQVQDVMLGRQG-ERMGLTGEPEGLNDGEWEQEDMERKAQGQ 317

Query: 484 G 484
           G
Sbjct: 318 G 318


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 38.9 bits (89), Expect = 0.019
 Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 25/140 (17%)

Query: 280 DKVHVGDGTGGGHGP-------ACAAVA-LRAALATAPNQGDDQP----LCIDDDLYQGQ 327
           D+  +G   G G  P       A +A++ L  +LA  P +    P    L + +      
Sbjct: 250 DRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPA 309

Query: 328 QQSHSEDHPA----PGPVVLPGQEVEGKDV-SRQTREADGEQNPKEEAPRGTGG-----E 377
            Q  ++D P+    P P   PG+E  G  V      + +GE++  E+APRG+ G     E
Sbjct: 310 AQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPE 369

Query: 378 VG---LHHTGKHEAEEAQGP 394
           VG       G+   EEAQGP
Sbjct: 370 VGEDAPQRLGEEPEEEAQGP 389


>gi|51172610 Rho guanine nucleotide exchange factor (GEF) 5-like
           [Homo sapiens]
          Length = 484

 Score = 38.5 bits (88), Expect = 0.025
 Identities = 42/181 (23%), Positives = 64/181 (35%), Gaps = 20/181 (11%)

Query: 304 ALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGE 363
           +L     Q +++     D+  Q +  S  E+HPA         E    + +       GE
Sbjct: 158 SLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPA---------ETNQNEGAESGTIRQGE 208

Query: 364 QNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGE 423
           + P EE     G    L H  + +  E QG Q+  + G       G L +        GE
Sbjct: 209 ELPSEELQESQG----LLHPQEVQVLEEQGQQEAGFRGE------GTLREDVCADGLLGE 258

Query: 424 HKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQ 483
            +  +      G Q           +  QG E +   G    L  G WEQE+ + +A  Q
Sbjct: 259 EQMIEQVNDEKGEQKQKQEQVQDVMLGRQG-ERMGLTGEPEGLNDGEWEQEDMERKAQGQ 317

Query: 484 G 484
           G
Sbjct: 318 G 318


>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
          Length = 957

 Score = 38.5 bits (88), Expect = 0.025
 Identities = 77/291 (26%), Positives = 104/291 (35%), Gaps = 52/291 (17%)

Query: 314 DQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGK----------DVSRQTREADGE 363
           D  L IDD     QQ  +   HP  G +++ GQ   GK          DV +     D E
Sbjct: 360 DVTLYIDD-----QQIENKPLHPVLG-ILINGQTQIGKYSGKEETVQFDVQKLRIYCDPE 413

Query: 364 QNPKEEAPR--GTGGEV--GLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQ 419
           QN +E A    G  GE   G    G   A     P K    GP+  P L     G  G+ 
Sbjct: 414 QNNRETACEIPGFNGECLNGPSDVGSTPAPCICPPGKPGLQGPKGDPGL----PGNPGYP 469

Query: 420 DDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQ 479
                + G + +P  G Q  A  P       +QG   L          PG   +  R   
Sbjct: 470 G----QPGQDGKP--GYQGIAGTPGVPGSPGIQGARGL----------PGYKGEPGRDGD 513

Query: 480 AHHQGF-----VDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQ----PQAGGGRGWEGR 530
              +G      + G PGS+  +       SP    ++   G+      P   G  G  GR
Sbjct: 514 KGDRGLPGFPGLHGMPGSKGEMGAKGDKGSPGFYGKKGAKGEKGNAGFPGLPGPAGEPGR 573

Query: 531 GAGRWARPGPGWDGGARAGTQGLP-LPGTEAEPGALGCSLSRGPVPRQGSL 580
                    PG+ G   AG+ G P   GT  EPG  G   +RG + ++G +
Sbjct: 574 HGKDGLMGSPGFKG--EAGSPGAPGQDGTRGEPGIPGFPGNRGLMGQKGEI 622


>gi|169214011 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 186

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 28/78 (35%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 508 PLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAG--TQGLPLPGTEAEPGAL 565
           P  R  W +++ + G GRG   RG GR  +P  G  GG  AG  T  + LP     P   
Sbjct: 103 PRGRGGW-EVRHRPGWGRGLHRRGLGRAEQPERGRAGGPGAGPRTPPMTLPSPPTLPAQD 161

Query: 566 GCSLSRGPVPRQGSLLSA 583
           G   +RGP P   + L+A
Sbjct: 162 GKKEARGPEPPLETPLAA 179


>gi|239756028 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 255

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 33/109 (30%), Positives = 40/109 (36%), Gaps = 16/109 (14%)

Query: 474 EERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGRGWEGRGAG 533
           EER +     G      G      +A +W  PP P    +      +A GGR W GRGAG
Sbjct: 12  EERGASPPGIGGPKSQWGKSGWFSIAASWRVPPPPAMGVL------KARGGRAWGGRGAG 65

Query: 534 RWARP----------GPGWDGGARAGTQGLPLPGTEAEPGALGCSLSRG 572
             + P          GP   GG R       LP   A P   G   S+G
Sbjct: 66  SQSLPRGGASARCDGGPKSQGGKRGWLSVPSLPRGGASPQCDGGPKSQG 114


>gi|113428768 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 186

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 28/78 (35%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 508 PLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAG--TQGLPLPGTEAEPGAL 565
           P  R  W +++ + G GRG   RG GR  +P  G  GG  AG  T  + LP     P   
Sbjct: 103 PRGRGGW-EVRHRPGWGRGLHRRGLGRAEQPERGRAGGPGAGPRTPPMTLPSPPTLPAQD 161

Query: 566 GCSLSRGPVPRQGSLLSA 583
           G   +RGP P   + L+A
Sbjct: 162 GKKEARGPEPPLETPLAA 179


>gi|113428351 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 186

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 28/78 (35%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 508 PLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAG--TQGLPLPGTEAEPGAL 565
           P  R  W +++ + G GRG   RG GR  +P  G  GG  AG  T  + LP     P   
Sbjct: 103 PRGRGGW-EVRHRPGWGRGLHRRGLGRAEQPERGRAGGPGAGPRTPPMTLPSPPTLPAQD 161

Query: 566 GCSLSRGPVPRQGSLLSA 583
           G   +RGP P   + L+A
Sbjct: 162 GKKEARGPEPPLETPLAA 179


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 37.4 bits (85), Expect = 0.055
 Identities = 70/244 (28%), Positives = 84/244 (34%), Gaps = 29/244 (11%)

Query: 338 PGPVVLPGQEVEGKDVSRQTREADGEQNPKE-EAPRGTGGEVGLHHT-GKHEAEEAQGPQ 395
           PGP    G+   G   S+    A GE  P   + P G  GE G     G+       GP 
Sbjct: 427 PGPKGNSGEP--GAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPP 484

Query: 396 KEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVE 455
            E   GP    F G    G AG +     +         G   +A RP        +G+ 
Sbjct: 485 GERG-GPGSRGFPGA--DGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLT 541

Query: 456 ALAAA-GWDMALGP-GPWEQEERQSQ-----AHHQGFVDGHPGSQARLWLALTWDSPPAP 508
               + G D   GP GP  Q+ R        A  Q  V G PG +           P   
Sbjct: 542 GSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAA------GEPGKA 595

Query: 509 LQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARA--GTQGLP----LPGTEAEP 562
            +R V G   P A G  G +G  AG    PGP    G R   G  G P    LPG    P
Sbjct: 596 GERGVPGP--PGAVGPAGKDGE-AGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPP 652

Query: 563 GALG 566
           G  G
Sbjct: 653 GEAG 656



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 71/237 (29%), Positives = 86/237 (36%), Gaps = 44/237 (18%)

Query: 366 PKEEAPRGTGGEVGLHHT-------GKHEAEEAQGPQKEEYLGPQQAP-FLGVLH-KGEA 416
           P +  PRG  GE G           G   A  A GP      GP   P F G +  KGEA
Sbjct: 298 PGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPT--GPAGPPGFPGAVGAKGEA 355

Query: 417 GHQ-----DDGEHKRGDNARPSH-GLQDDAPRPRAVTQVVVQGVEAL----AAAGWDMAL 466
           G Q     +  +  RG+   P   G    A  P A  Q   +G         A G+  A 
Sbjct: 356 GPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGAR 415

Query: 467 GP-GPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAGGGR 525
           GP GP           + G   G PGS+            P P+     G   P   G  
Sbjct: 416 GPSGPQGPGGPPGPKGNSG-EPGAPGSKGDTGAK----GEPGPV-----GVQGPP--GPA 463

Query: 526 GWEGRGAGRWARPGP-GWDG--GARAGTQGLPLPGTEAEPGALGCSLSRGPVPRQGS 579
           G EG+   R   PGP G  G  G R G      PG+   PGA G +  +GP   +GS
Sbjct: 464 GEEGKRGAR-GEPGPTGLPGPPGERGG------PGSRGFPGADGVAGPKGPAGERGS 513



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 91/364 (25%), Positives = 109/364 (29%), Gaps = 77/364 (21%)

Query: 231 PHHPYGNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGG 290
           P  P G  G  GE      + P  +   +G PG       + +D            G  G
Sbjct: 282 PAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDG---------ATGAAG 332

Query: 291 GHGPACAA--VALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHP-----APGPVVL 343
             GP   A       A+      G   P   +     G Q    E  P     A GP   
Sbjct: 333 PPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSE-----GPQGVRGEPGPPGPAGAAGPAGN 387

Query: 344 PGQE-------------VEGKDVSRQTREADGEQNPK-EEAPRGTGGEVGLHHT-GKHEA 388
           PG +             + G       R   G Q P     P+G  GE G   + G   A
Sbjct: 388 PGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGA 447

Query: 389 EEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAPRPRAVTQ 448
           +   GP     +G Q  P       G AG     E KRG    P        P  R    
Sbjct: 448 KGEPGP-----VGVQGPP-------GPAGE----EGKRGARGEPGPTGLPGPPGERG--- 488

Query: 449 VVVQGVEALAAAGWDMALGP-GPWEQEERQSQAHHQGFVD--GHPGSQARLWLALTWDSP 505
               G  +    G D   GP GP  +      A  +G     G PG            SP
Sbjct: 489 ----GPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSP 544

Query: 506 PAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGAR--AGTQGLPLP-GTEAEP 562
            +P      G   P            AG+  RPGP    GAR  AG  G P P G   EP
Sbjct: 545 GSPGPDGKTGPPGP------------AGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEP 592

Query: 563 GALG 566
           G  G
Sbjct: 593 GKAG 596



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 62/248 (25%), Positives = 78/248 (31%), Gaps = 20/248 (8%)

Query: 338 PGPVVLPGQEVEGKDVSRQTREADGEQNPK----EEAPRGTGGEVGLHHTGKHEAEEAQG 393
           PGP    G    GKD     +   G   P     E+ P G+ G  GL        E  + 
Sbjct: 601 PGPPGAVGPA--GKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGK- 657

Query: 394 PQKEEYLGPQQAPFLGVLH-----KGEAGHQDDG--EHKRGDNARPSH-GLQDDAPRPRA 445
           P ++   G   AP            GE G Q        RG N  P + G + DA  P A
Sbjct: 658 PGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGA 717

Query: 446 VTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSP 505
                  G++ +        L PGP   +  +  A  +G  DG PG      L      P
Sbjct: 718 PGSQGAPGLQGMPGERGAAGL-PGP---KGDRGDAGPKG-ADGSPGKDGVRGLTGPIGPP 772

Query: 506 PAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARAGTQGLPLPGTEAEPGAL 565
                    G+  P    G        G    PGP    G          PG + EPG  
Sbjct: 773 GPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDA 832

Query: 566 GCSLSRGP 573
           G     GP
Sbjct: 833 GAKGDAGP 840



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 72/267 (26%), Positives = 90/267 (33%), Gaps = 48/267 (17%)

Query: 338 PGPVVLPGQEVEGKDVSRQTREADGEQNPK-EEAPRGTGGEVGLHHTGKHEAEEAQGPQK 396
           PGP   PG+  +  +  +  R   GE+ P   +  RG  G  GL     H         K
Sbjct: 223 PGP---PGKNGDDGEAGKPGRP--GERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAK 277

Query: 397 EEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSH----GLQDDAPRPRAVTQVVVQ 452
            +  GP          KGE G         G+N  P      GL  +  RP A      +
Sbjct: 278 GD-AGPAGP-------KGEPGSP-------GENGAPGQMGPRGLPGERGRPGAPGPAGAR 322

Query: 453 GVE-ALAAAGWDMALGP-GP-------------WEQEERQSQAHHQGFVDGHPGSQARLW 497
           G + A  AAG     GP GP               Q  R S+   QG V G PG      
Sbjct: 323 GNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGP-QG-VRGEPGPPGPAG 380

Query: 498 LALTWDSPPAPLQRSVWGQL-QPQAGGGRGWEG-RGA----GRWARPGPGWDGGARAGTQ 551
            A    +P A  Q    G    P   G  G+ G RG     G    PGP  + G      
Sbjct: 381 AAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPG 440

Query: 552 GLPLPGTEAEPGALGCSLSRGPVPRQG 578
                G + EPG +G     GP   +G
Sbjct: 441 SKGDTGAKGEPGPVGVQGPPGPAGEEG 467



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 13/78 (16%)

Query: 505 PPAPLQRSVWGQLQPQAGGGRGWEGRGAGRWARPGPGWDGGARA--GTQGLP-------L 555
           PP P    + G   PQ     G++ +  G  + PGP    G R   G  G P        
Sbjct: 149 PPGP--PGLGGNFAPQLS--YGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGP 204

Query: 556 PGTEAEPGALGCSLSRGP 573
           PG   EPGA G    RGP
Sbjct: 205 PGEPGEPGASGPMGPRGP 222


>gi|122937233 discs, large (Drosophila) homolog-associated protein 3
           [Homo sapiens]
          Length = 979

 Score = 37.0 bits (84), Expect = 0.071
 Identities = 54/229 (23%), Positives = 79/229 (34%), Gaps = 41/229 (17%)

Query: 183 AGLGHLGDLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAV-------SIHDDPHHPY 235
           AGLGH+   G  +   EGP +G EG      + GG+              +  D   HP 
Sbjct: 52  AGLGHISPEGP-LSLSEGPSVGPEGGPAGAGVGGGSSTFPRMYPGQGPFDTCEDCVGHPQ 110

Query: 236 GNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPA 295
           G G         P L P L+          +  +Q     D  H   +     G G GPA
Sbjct: 111 GKGA--------PRLPPTLL---------DQFEKQLPVQQDGFHTLPYQRGPAGAGPGPA 153

Query: 296 CAAVALRAALATAPNQGDDQPLCIDDDLYQGQQ---QSHSEDHPAPGPVVLPGQEVEGKD 352
                      TAP    + P  I   ++  Q+   +SHS +  APG     G + EG+ 
Sbjct: 154 -------PGTGTAPEPRSESPSRIRHLVHSVQKLFAKSHSLE--APGKRDYNGPKAEGRG 204

Query: 353 VSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQKEEYLG 401
            S      D    P    P  +      HH   H++   +  + ++  G
Sbjct: 205 GS----GGDSYPGPGSGGPHTSHHHHHHHHHHHHQSRHGKRSKSKDRKG 249


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 37.0 bits (84), Expect = 0.071
 Identities = 73/320 (22%), Positives = 102/320 (31%), Gaps = 57/320 (17%)

Query: 259  QGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQPLC 318
            +GGPGP              H +   GDG G   GP  A    R      P   +D    
Sbjct: 1047 RGGPGPPFPPD---------HREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFR 1097

Query: 319  --IDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGT-- 374
               ++   +G    H    P  G    PG E  G + +    E            RGT  
Sbjct: 1098 GRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPR 1157

Query: 375  GGEVGLHHTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSH 434
            GG  GL  T   E    +G +K +     + P          GH+   +  R D+  P H
Sbjct: 1158 GGRKGLLPT-PDEFPRFEGGRKPDSWDGNREP--------GPGHEHFRDTPRPDH--PPH 1206

Query: 435  GLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQA------HHQGFVDG 488
                 A R R+ +   +QG++  +          GP   E R+ +A         G   G
Sbjct: 1207 DGHSPASRERSSS---LQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRG 1263

Query: 489  HPGSQARLWLALTWDSPPAPLQRSVWGQLQ-----------PQAGGGRGWEGRGAGRWAR 537
             PG   R+        P +    S+ G+             P   G     GR    W R
Sbjct: 1264 GPGPAQRV--------PKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGR 1315

Query: 538  -----PGPGWDGGARAGTQG 552
                  GP   G +R G +G
Sbjct: 1316 GSNMNSGPPRRGASRGGGRG 1335



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 69/296 (23%), Positives = 98/296 (33%), Gaps = 46/296 (15%)

Query: 199 EGPGIGGEGDGQRGVI-PGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPM--LTPALV 255
           +GP +   G G +G + P G       +    D H P G      + H  P   L P   
Sbjct: 638 QGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGM-----QRHPGPHGPLGP--- 689

Query: 256 AATQGGPGPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQ 315
              QG PGPQ  +  Q H   +         G  G  GP    +  +    T   QG   
Sbjct: 690 ---QGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQ-GHLGPQGPPGTQGMQGPPG 745

Query: 316 PLCIDDDLYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTG 375
           P  +     QG    H      PG   + G   +G  +    R   G   P+E       
Sbjct: 746 PRGM-----QGPPHPHG-IQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQ 799

Query: 376 GEV---------GLHHTG---KHEAEEAQGPQKEEYL--GPQQAPFLGVLH--KGEAGHQ 419
           G +         G H  G    H  +E +GPQ+   +   P Q   LG     +G  G Q
Sbjct: 800 GMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQ 859

Query: 420 DDGEHKRGDNARPSHGLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEE 475
                 +G    P  G     P P+          +   A G   + GP P++Q++
Sbjct: 860 SQQGPPQGSLGPPPQGGMQGPPGPQG---------QQNPARGPHPSQGPIPFQQQK 906



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 31/123 (25%), Positives = 46/123 (37%), Gaps = 20/123 (16%)

Query: 325 QGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTG 384
           QGQQ      HP+ GP+  P Q+       +     DG + P  +  + TG    +   G
Sbjct: 884 QGQQNPARGPHPSQGPI--PFQQ------QKTPLLGDGPRAPFNQEGQSTGPPPLIPGLG 935

Query: 385 KHEAE---------EAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHG 435
           +  A+         +  GP K +  GP   P   +    E  H+  G  + G    P  G
Sbjct: 936 QQGAQGRIPPLNPGQGPGPNKGDSRGP---PNHHMGPMSERRHEQSGGPEHGPERGPFRG 992

Query: 436 LQD 438
            QD
Sbjct: 993 GQD 995


>gi|4502081 amphiphysin isoform 1 [Homo sapiens]
          Length = 695

 Score = 36.6 bits (83), Expect = 0.093
 Identities = 29/116 (25%), Positives = 49/116 (42%), Gaps = 8/116 (6%)

Query: 334 DHPAPGPVVLPGQEVEGK--DVSRQTREADGEQNPKEEA--PRGTGGEVGLHHTGKHEAE 389
           + P    V++PG + +     +      A GE+   E+A  P G G  +     G    E
Sbjct: 459 EEPVEEAVIIPGADADAAVGTLVSAAEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTE 518

Query: 390 EAQGPQKE----EYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAP 441
            A+  Q E    E   PQ+     V+ +  + H+++GE++    A P    +D AP
Sbjct: 519 GAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAAP 574


>gi|154146231 DMRT-like family A2 [Homo sapiens]
          Length = 542

 Score = 36.6 bits (83), Expect = 0.093
 Identities = 82/319 (25%), Positives = 106/319 (33%), Gaps = 92/319 (28%)

Query: 287 GTGGGHGPACAAVA------------LRAALATAPNQGDDQPLCIDDDLYQGQQQSHSED 334
           GTGGG   A  + A            L+A    +P     +PL   D    G   S  E 
Sbjct: 175 GTGGGAAGAGGSEAKLQKFDLFPKTLLQAGRPGSPLPPPVKPLS-PDGADSGPGTSSPEV 233

Query: 335 HPAPGPVVLPGQEVEGKDVSRQTREADG-------------EQNPKEEAPRGTGGEVGLH 381
            P  G     G+   G  ++R ++EA G             E +P   +P G+  E G  
Sbjct: 234 RPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGPGGGGEEDSPGSASPLGS--ESG-S 290

Query: 382 HTGKHEAEEAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSHGLQDDAP 441
              K E E A  P      GP+Q   L +L +   GH+                      
Sbjct: 291 EADKEEGEAAPAPGLGGGSGPRQRTPLDILTRVFPGHR---------------------- 328

Query: 442 RPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALT 501
             R V ++V+QG       G D+        Q   Q   HH+G      G  A L     
Sbjct: 329 --RGVLELVLQG------CGGDVV-------QAIEQVLNHHRG------GLAAGL----- 362

Query: 502 WDSPPAPLQRSVWGQLQPQAGGGRGWEGR----GAGRWARPGPGWDGGARAGTQGLP--- 554
              P AP  ++  G     A     W  R     A   A  GPG     +AG    P   
Sbjct: 363 --GPAAPPDKAAVG---AAAAADDAWPSRVDAAAAAAAAAGGPGLPAPLQAGPAAPPHHR 417

Query: 555 --LPGTEAEPGALGCSLSR 571
             L G  A PGALG   SR
Sbjct: 418 PLLAGAMA-PGALGSLSSR 435



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 39/138 (28%), Positives = 51/138 (36%), Gaps = 14/138 (10%)

Query: 190 DLGDDVEEDEGPGIGGEGDGQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPM 249
           + G       GPG GGE D      P G+     A     +     G GGG G   + P 
Sbjct: 258 EAGGSCPGSAGPGGGGEEDSPGSASPLGSESGSEADKEEGEAAPAPGLGGGSGPRQRTP- 316

Query: 250 LTPALVAATQGGPGPQEGT-----QQQQHDVDECHDKV--HVGDGTGGGHGPACAAVALR 302
               L   T+  PG + G      Q    DV +  ++V  H   G   G GP  AA   +
Sbjct: 317 ----LDILTRVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGP--AAPPDK 370

Query: 303 AALATAPNQGDDQPLCID 320
           AA+  A    D  P  +D
Sbjct: 371 AAVGAAAAADDAWPSRVD 388


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 36.6 bits (83), Expect = 0.093
 Identities = 33/105 (31%), Positives = 41/105 (39%), Gaps = 9/105 (8%)

Query: 34   HWPAEAGLCS----PDVSRGPGEPTYRNFVHQGHLSGLVHTGQQLPIVPATPQPLTQQLR 89
            HWP E GL      P     P  PT    V  G  SG+ H G+ + +V  TP P   + R
Sbjct: 2297 HWPRE-GLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTTPIP-QMEAR 2354

Query: 90   KCSVSNFHIPIRPPGPEAKRT-HGPSAAFQDGQPPALPVTTGQLP 133
                    + + PP P    T  G S A   G  P +    GQ P
Sbjct: 2355 TLPPGMAAVTVVPPHPVTPATPAGQSVA--PGPFPPVQCGPGQTP 2397


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 56/282 (19%), Positives = 90/282 (31%), Gaps = 65/282 (23%)

Query: 186 GHLGDLGDDVEEDEG-------PGIGGEGD-------------GQRGVIPGGTVVLLVAV 225
           GH G  G    + EG         + G G              G+ G   G +   L  V
Sbjct: 413 GHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQV 472

Query: 226 SIHDDPHHPYGNGGGCGEEHKDPMLTPALVAATQGGPGPQEGTQQQQHDVDECHDKVHVG 285
           S H+ P   +G  G                       G ++G+  +Q      H     G
Sbjct: 473 STHEQPDSAHGRTGT--------------------STGGRQGSHHEQARDSSRHSASQEG 512

Query: 286 DGTGGGHGPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQQQSHSEDHPAPGPVVLPG 345
             T  GH  +          +    QG      ++   + G   SH+      G      
Sbjct: 513 QDTIRGHPGS----------SRGGRQGSHHEQSVNRSGHSGSHHSHTTSQ---GRSDASH 559

Query: 346 QEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHHTGKHEAEEAQGPQ--KEEYLGPQ 403
            +   +  SRQTR        +E++  GT      HH    +A+ ++  Q  + +  GP+
Sbjct: 560 GQSGSRSASRQTRN-------EEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPR 612

Query: 404 QAPFLGVLHKGEA---GHQDDGEHKRGDNARPSHGLQDDAPR 442
            +   G     ++   GH +D E   G  +R  HG   +  R
Sbjct: 613 TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSR 654



 Score = 33.5 bits (75), Expect = 0.79
 Identities = 64/300 (21%), Positives = 92/300 (30%), Gaps = 76/300 (25%)

Query: 209  GQRGVIPGGTVVLLVAVSIHDDPHHPYGNGGGCGEEHKDPMLTPALVAATQGGPGPQEGT 268
            GQ G   G +   L  VS H+     +G                   A + GG   ++G+
Sbjct: 2078 GQSGESSGRSGSFLYQVSTHEQSESTHGQS-----------------APSTGG---RQGS 2117

Query: 269  QQQQHDVDECHDKVHVGDGTGGGH-GPACAAVALRAALATAPNQGDDQPLCIDDDLYQGQ 327
               Q      H     G  T  GH GP+               QG  Q   +D   + G 
Sbjct: 2118 HYDQAQDSSRHSASQEGQDTIRGHPGPSRGG-----------RQGSHQEQSVDRSGHSGS 2166

Query: 328  QQSHSEDHPAPGPVVLPGQEVEGKDVSRQ---TREADGEQNPKEEAPRGTGGEVGLHHTG 384
              SH+                   D SR    +R A  +   KE++  G+      HH  
Sbjct: 2167 HHSHTTSQGR-------------SDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEA 2213

Query: 385  KHEAE----------EAQGPQKEEYLGPQQAPFLGVLHKGEAGHQDDGEHKRGDNARPSH 434
               A+          ++ GP+     G   +           GH +D E + G  +R  H
Sbjct: 2214 SSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQ-----DSDSEGHSEDSERRSGSASRNHH 2268

Query: 435  GLQDDAPRPRAVTQVVVQGVEALAAAGWDMALGPGPWEQEERQSQAHHQGFVDGHPGSQA 494
            G   +  R          G     +   D A G G   +  RQS  HH    +   G QA
Sbjct: 2269 GSAQEQSR---------DGSRHPRSHHEDRA-GHGHSAESSRQSGTHH---AENSSGGQA 2315



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 41/193 (21%), Positives = 68/193 (35%), Gaps = 30/193 (15%)

Query: 263  GPQEGTQQQQHDVDECHDKVHVGDGTGGGHGPACAAVALRAALATAPNQGDDQPLCIDDD 322
            G ++G+  +Q      H     G  T  GH  +          ++   QG      +D  
Sbjct: 2436 GGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGS----------SSGGRQGSHYEQLVDRS 2485

Query: 323  LYQGQQQSHSEDHPAPGPVVLPGQEVEGKDVSRQTREADGEQNPKEEAPRGTGGEVGLHH 382
             + G   SH+      G           +  SRQTR         E++  G+      HH
Sbjct: 2486 GHSGSHHSHTTSQ---GRSDASHGHSGSRSASRQTRN-------DEQSGDGSRHSGSRHH 2535

Query: 383  TGKHEAEEAQGPQ--KEEYLGPQQAPFLGVLHKGEA---GHQDDGEHKRGDNARPSHG-- 435
                 A+ +   Q  + +  GP+ +   G     ++   GH +D E   G  +R  HG  
Sbjct: 2536 EASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSA 2595

Query: 436  ---LQDDAPRPRA 445
               L+D +  PR+
Sbjct: 2596 QEQLRDGSRHPRS 2608


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,119,551
Number of Sequences: 37866
Number of extensions: 2556335
Number of successful extensions: 10572
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 292
Number of HSP's that attempted gapping in prelim test: 9631
Number of HSP's gapped (non-prelim): 1191
length of query: 791
length of database: 18,247,518
effective HSP length: 110
effective length of query: 681
effective length of database: 14,082,258
effective search space: 9590017698
effective search space used: 9590017698
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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