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Search of human proteins with 116534990
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116534990 ankyrin-like protein 1 [Homo sapiens]
(1119 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 2266 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 187 4e-47
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 187 4e-47
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 187 4e-47
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 187 4e-47
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 187 4e-47
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 187 4e-47
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 182 2e-45
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 180 6e-45
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 180 6e-45
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 180 6e-45
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 170 6e-42
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 165 3e-40
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 162 2e-39
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 162 2e-39
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 160 5e-39
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 160 5e-39
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 154 3e-37
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 137 4e-32
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 134 6e-31
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 130 5e-30
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 129 2e-29
gi|34304381 inversin isoform a [Homo sapiens] 123 9e-28
gi|34304379 inversin isoform b [Homo sapiens] 123 9e-28
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 121 3e-27
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 120 7e-27
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 119 2e-26
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 111 3e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 109 1e-23
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 105 2e-22
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 2266 bits (5872), Expect = 0.0
Identities = 1119/1119 (100%), Positives = 1119/1119 (100%)
Query: 1 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD 60
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
Sbjct: 1 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD 60
Query: 61 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 120
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
Sbjct: 61 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 120
Query: 121 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 180
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
Sbjct: 121 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 180
Query: 181 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 240
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
Sbjct: 181 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 240
Query: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
Sbjct: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
Sbjct: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
Query: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
Sbjct: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
Query: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 480
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
Sbjct: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 480
Query: 481 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 540
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
Sbjct: 481 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 540
Query: 541 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 600
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
Sbjct: 541 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 600
Query: 601 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 660
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
Sbjct: 601 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 660
Query: 661 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM 720
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
Sbjct: 661 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM 720
Query: 721 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS 780
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
Sbjct: 721 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS 780
Query: 781 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY 840
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
Sbjct: 781 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY 840
Query: 841 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS 900
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
Sbjct: 841 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS 900
Query: 901 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA 960
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
Sbjct: 901 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA 960
Query: 961 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF 1020
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
Sbjct: 961 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF 1020
Query: 1021 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED 1080
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
Sbjct: 1021 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED 1080
Query: 1081 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1119
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
Sbjct: 1081 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1119
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 187 bits (476), Expect = 4e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 115 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 227
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 279
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 280 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 337
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 338 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 396 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 450
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 451 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 507
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 508 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 566
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Score = 180 bits (457), Expect = 6e-45
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 276 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 390
Query: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 442
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 443 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 498
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 559 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 606
Query: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 663
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 724 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 596 VLTIIRS 602
V ++++
Sbjct: 783 VTLLLKN 789
Score = 174 bits (441), Expect = 4e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 309 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 477
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 533
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 594 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 641
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 698
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 699 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
D N K + G + LH AA++GH V LLL + A
Sbjct: 759 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 791
Score = 174 bits (440), Expect = 5e-43
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 297
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 358 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 410 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 523
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 524 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 581 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 634
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
Query: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
L NK + LHL V +I+
Sbjct: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Score = 146 bits (369), Expect = 9e-35
Identities = 129/471 (27%), Positives = 212/471 (45%), Gaps = 28/471 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 408 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLE--------KEASQACMTKKGFTPLHVA 576
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR--GGSPHSPAWN 634
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 635 GY--TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
++ + G LHL Q+ + P + + +V G TPLH A G
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGH-----VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V LL +++K+K SPLH AA G + LL++ + NE G TPL
Sbjct: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPL 804
Query: 487 HLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTN 537
+A + G+ V +L ++D + + + +T+ ILD +
Sbjct: 805 AIAKRLGYISVTDVL-----KVVTDETSFVLVSDKHRMSFPETVDEILDVS 850
Score = 141 bits (356), Expect = 3e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 129 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
Query: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 181 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 291
Query: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 292 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 347
Query: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 348 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
Query: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
V N + + LH+A EV ++++K
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
Score = 110 bits (275), Expect = 7e-24
Identities = 100/364 (27%), Positives = 157/364 (43%), Gaps = 52/364 (14%)
Query: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299
AT A ++G+L+ L NG I+ + +H A+ +G VK+++ +
Sbjct: 46 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEI 102
Query: 300 DIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVN 359
I+ TT T LH A+L E+ L++ GA++N +G +PL +A +V
Sbjct: 103 -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
Query: 360 LLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHY 419
LL GA ++ DG TPL
Sbjct: 162 FLLENGANQNV--------------------------------------ATEDGFTPLAV 183
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +QG V +L+ + +K K + LH AA T LLQ+ + +L++
Sbjct: 184 ALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK-- 237
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNL 538
G TPLH+AA + V QLLL +GA + + NG T LH AS G ++++LD
Sbjct: 238 -TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296
Query: 539 KCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVL 597
+ + +D T LH AAR GH + +LL H A I K S +H+A + V
Sbjct: 297 QIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 355
Query: 598 TIIR 601
+++
Sbjct: 356 LLLQ 359
Score = 59.7 bits (143), Expect = 2e-08
Identities = 50/192 (26%), Positives = 85/192 (44%), Gaps = 8/192 (4%)
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
D T A R G + L V I++ +++ + LH A+ G + LL
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---K 100
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
+L G T LH+AA G D+VV+ L+ GA + G+T L+ A+ + + +
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHN 590
K +L+ + EDG T L A ++GH VA L+++ K + LH+A N
Sbjct: 161 KFLLENGAN-QNVATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARN 216
Query: 591 KRKEVVLTIIRS 602
++++
Sbjct: 217 DDTRTAAVLLQN 228
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 187 bits (476), Expect = 4e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 180 bits (457), Expect = 6e-45
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
Query: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 596 VLTIIRS 602
V ++++
Sbjct: 750 VTLLLKN 756
Score = 174 bits (441), Expect = 4e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
D N K + G + LH AA++GH V LLL + A
Sbjct: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 174 bits (440), Expect = 5e-43
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
L NK + LHL V +I+
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 148 bits (373), Expect = 3e-35
Identities = 133/498 (26%), Positives = 222/498 (44%), Gaps = 35/498 (7%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLE--------KEASQACMTKKGFTPLHVA 543
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR--GGSPHSPAWN 601
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 602 GY--TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
++ + G LHL Q+ + P + + +V G TPLH A G
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGH-----VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V LL +++K+K SPLH AA G + LL++ + NE G TPL
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPL 771
Query: 487 HLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE 546
+A + G+ V +L ++D + + + +T+ ILD + ++
Sbjct: 772 AIAKRLGYISVTDVL-----KVVTDETSFVLVSDKHRMSFPETVDEILDVS-------ED 819
Query: 547 DGNTALHFAAREGHAKAV 564
+G + F A ++ V
Sbjct: 820 EGEELISFKAERRDSRDV 837
Score = 141 bits (356), Expect = 3e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 96 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Query: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Query: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
V N + + LH+A EV ++++K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Score = 112 bits (279), Expect = 3e-24
Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
+ F AT A ++G+L+ L NG I+ + +H A+ +G VK++
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
Query: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+ + I+ TT T LH A+L E+ L++ GA++N +G +PL +A
Sbjct: 62 VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411
+V LL GA ++
Sbjct: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
DG TPL A +QG V +L+ + +K K + LH AA T LLQ+ +
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
+L++ G TPLH+AA + V QLLL +GA + + NG T LH AS G +
Sbjct: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
+++LD + + +D T LH AAR GH + +LL H A I K S +H+A
Sbjct: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 590 NKRKEVVLTIIR 601
+ V +++
Sbjct: 315 GDHLDCVRLLLQ 326
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 187 bits (476), Expect = 4e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 180 bits (457), Expect = 6e-45
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
Query: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 596 VLTIIRS 602
V ++++
Sbjct: 750 VTLLLKN 756
Score = 174 bits (441), Expect = 4e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
D N K + G + LH AA++GH V LLL + A
Sbjct: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 174 bits (440), Expect = 5e-43
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
L NK + LHL V +I+
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 148 bits (373), Expect = 3e-35
Identities = 133/498 (26%), Positives = 222/498 (44%), Gaps = 35/498 (7%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLE--------KEASQACMTKKGFTPLHVA 543
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR--GGSPHSPAWN 601
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 602 GY--TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
++ + G LHL Q+ + P + + +V G TPLH A G
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGH-----VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V LL +++K+K SPLH AA G + LL++ + NE G TPL
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPL 771
Query: 487 HLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE 546
+A + G+ V +L ++D + + + +T+ ILD + ++
Sbjct: 772 AIAKRLGYISVTDVL-----KVVTDETSFVLVSDKHRMSFPETVDEILDVS-------ED 819
Query: 547 DGNTALHFAAREGHAKAV 564
+G + F A ++ V
Sbjct: 820 EGEELISFKAERRDSRDV 837
Score = 141 bits (356), Expect = 3e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 96 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Query: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Query: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
V N + + LH+A EV ++++K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Score = 112 bits (279), Expect = 3e-24
Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
+ F AT A ++G+L+ L NG I+ + +H A+ +G VK++
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
Query: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+ + I+ TT T LH A+L E+ L++ GA++N +G +PL +A
Sbjct: 62 VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411
+V LL GA ++
Sbjct: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
DG TPL A +QG V +L+ + +K K + LH AA T LLQ+ +
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
+L++ G TPLH+AA + V QLLL +GA + + NG T LH AS G +
Sbjct: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
+++LD + + +D T LH AAR GH + +LL H A I K S +H+A
Sbjct: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 590 NKRKEVVLTIIR 601
+ V +++
Sbjct: 315 GDHLDCVRLLLQ 326
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 187 bits (476), Expect = 4e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 180 bits (457), Expect = 6e-45
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
Query: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 596 VLTIIRS 602
V ++++
Sbjct: 750 VTLLLKN 756
Score = 174 bits (441), Expect = 4e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
D N K + G + LH AA++GH V LLL + A
Sbjct: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 174 bits (440), Expect = 5e-43
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
L NK + LHL V +I+
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 148 bits (373), Expect = 3e-35
Identities = 133/498 (26%), Positives = 222/498 (44%), Gaps = 35/498 (7%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLE--------KEASQACMTKKGFTPLHVA 543
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR--GGSPHSPAWN 601
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 602 GY--TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
++ + G LHL Q+ + P + + +V G TPLH A G
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGH-----VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V LL +++K+K SPLH AA G + LL++ + NE G TPL
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPL 771
Query: 487 HLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE 546
+A + G+ V +L ++D + + + +T+ ILD + ++
Sbjct: 772 AIAKRLGYISVTDVL-----KVVTDETSFVLVSDKHRMSFPETVDEILDVS-------ED 819
Query: 547 DGNTALHFAAREGHAKAV 564
+G + F A ++ V
Sbjct: 820 EGEELISFKAERRDSRDV 837
Score = 141 bits (356), Expect = 3e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 96 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Query: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Query: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
V N + + LH+A EV ++++K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Score = 112 bits (279), Expect = 3e-24
Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
+ F AT A ++G+L+ L NG I+ + +H A+ +G VK++
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
Query: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+ + I+ TT T LH A+L E+ L++ GA++N +G +PL +A
Sbjct: 62 VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411
+V LL GA ++
Sbjct: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
DG TPL A +QG V +L+ + +K K + LH AA T LLQ+ +
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
+L++ G TPLH+AA + V QLLL +GA + + NG T LH AS G +
Sbjct: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
+++LD + + +D T LH AAR GH + +LL H A I K S +H+A
Sbjct: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 590 NKRKEVVLTIIR 601
+ V +++
Sbjct: 315 GDHLDCVRLLLQ 326
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 187 bits (476), Expect = 4e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 180 bits (457), Expect = 6e-45
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
Query: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 596 VLTIIRS 602
V ++++
Sbjct: 750 VTLLLKN 756
Score = 174 bits (441), Expect = 4e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
D N K + G + LH AA++GH V LLL + A
Sbjct: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 174 bits (440), Expect = 5e-43
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
L NK + LHL V +I+
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 148 bits (373), Expect = 3e-35
Identities = 133/498 (26%), Positives = 222/498 (44%), Gaps = 35/498 (7%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLE--------KEASQACMTKKGFTPLHVA 543
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR--GGSPHSPAWN 601
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 602 GY--TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
++ + G LHL Q+ + P + + +V G TPLH A G
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGH-----VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
V LL +++K+K SPLH AA G + LL++ + NE G TPL
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPL 771
Query: 487 HLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE 546
+A + G+ V +L ++D + + + +T+ ILD + ++
Sbjct: 772 AIAKRLGYISVTDVL-----KVVTDETSFVLVSDKHRMSFPETVDEILDVS-------ED 819
Query: 547 DGNTALHFAAREGHAKAV 564
+G + F A ++ V
Sbjct: 820 EGEELISFKAERRDSRDV 837
Score = 141 bits (356), Expect = 3e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 96 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
Query: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Query: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
V N + + LH+A EV ++++K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Score = 112 bits (279), Expect = 3e-24
Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
+ F AT A ++G+L+ L NG I+ + +H A+ +G VK++
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
Query: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+ + I+ TT T LH A+L E+ L++ GA++N +G +PL +A
Sbjct: 62 VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411
+V LL GA ++
Sbjct: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
DG TPL A +QG V +L+ + +K K + LH AA T LLQ+ +
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
+L++ G TPLH+AA + V QLLL +GA + + NG T LH AS G +
Sbjct: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
+++LD + + +D T LH AAR GH + +LL H A I K S +H+A
Sbjct: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Query: 590 NKRKEVVLTIIR 601
+ V +++
Sbjct: 315 GDHLDCVRLLLQ 326
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 187 bits (476), Expect = 4e-47
Identities = 154/565 (27%), Positives = 259/565 (45%), Gaps = 55/565 (9%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ GQ E+++ + + + ++ G TPL+ A ++N +E VKFLL GA+ +L
Sbjct: 111 LHIASLAGQAEVVKVLVTNGAN--VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q +++V+ +LLE+ T +G+ A+ IA ++++A +LL+
Sbjct: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDT-----KGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
+K G P+H AA G+ ++L +R ++F TPLH+A
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLL--------NRAAAVDFTARNDITPLHVA 275
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMI--------SSYSGS 298
+ G+ M+K+ LD GA+ID + T +H A G ++V++++ + +G
Sbjct: 276 SKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335
Query: 299 VDIVNTTDGCH---------------------ETMLHRASLFDHHELADYLISVGADINK 337
+ T G H T LH A+ H+++A L+ A+ N
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
G +PL +A ++ LLL GA + G +H+ G N+ + M
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM--GHVNIVSQLM 453
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
+ G T LH A R G V L+ + +K+KD ++PLH +A G
Sbjct: 454 HHGASPNTT---NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWT 516
+ + Q+LLQ + N G TPLHL+A+ GH+ V LL GA L ++ G+T
Sbjct: 511 KADIVQQLLQQGASP---NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFT 567
Query: 517 ALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD-IV 575
LH A+ G + ++L + D + G T LH AA + K LLL A
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSAS-PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 576 LNKQQASFLHLALHNKRKEVVLTII 600
K + LH+A + ++ T++
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLL 651
Score = 179 bits (454), Expect = 1e-44
Identities = 146/546 (26%), Positives = 246/546 (45%), Gaps = 70/546 (12%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G ++ K+ D ++ + D G TPLHC + V+ LL R A
Sbjct: 272 LHVASKRGNANMV-KLLLDRGAKIDAKTRD-GLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--------------------------------R 154
+ N ++PLH+A QG + +++LL+H +
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 155 TIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
+ N + NG T + IAC N + +++LLK GA + G PIH AAF G +
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
++ HG S N N T LH+A ++G E+++ + +GAQ++ K T
Sbjct: 450 SQLMH----HGASP----NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+H +A G +IV+ ++ G+ TT G T LH ++ H ++A +L+ GA
Sbjct: 502 PLHISARLGKADIVQQLLQQ--GASPNAATTSGY--TPLHLSAREGHEDVAAFLLDHGAS 557
Query: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRP 394
++ +G +PL +A + NLLL K A D G LH+
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY--------- 608
Query: 395 EFMQMQQIKELVMDED-------NDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK 447
Q++ L++D+ +G TPLH A ++ LL + ++ ++
Sbjct: 609 ---DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI 665
Query: 448 SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA- 506
+ +H AA G ++ LL ++ L N+ G+TPLHLAA+ V ++L+ +GA
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNANVNLSNKS---GLTPLHLAAQEDRVNVAEVLVNQGAH 722
Query: 507 LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVAL 566
+ G+T LH G + + +L + K + ++G T LH AA++GH + +
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINV 781
Query: 567 LLSHNA 572
LL +NA
Sbjct: 782 LLQNNA 787
Score = 177 bits (450), Expect = 4e-44
Identities = 138/505 (27%), Positives = 231/505 (45%), Gaps = 24/505 (4%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
G TPLH A I LL+R A + N + PLH+A + N ++K+LL+ R
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD-RGAK 293
Query: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
++ + +G T + + + + +++LL + A K G P+H A C++++
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
Query: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
L+ + ++ + N T LH+A G ++ K+ LD A + T +H
Sbjct: 354 LQ--------HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405
Query: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
A + ++++L++ + S+ V T G T +H A+ H + L+ GA N
Sbjct: 406 IACKKNRIKVMELLLK-HGASIQAV-TESGL--TPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+ G + L +A S +V L+ GAQV+ K + LH++ + G ++ + +
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR--LGKADIVQQLL 519
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
Q G TPLH + R+G LL S+ +K +PLH AA YG
Sbjct: 520 QQGASPNAAT---TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWT 516
++ LLQ + + G+TPLH+AA + KV LLL +GA + NG+T
Sbjct: 577 KLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 517 ALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVL 576
LH A+ +L+ + + G ++H AA+EGH V+LLL NA++ L
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADA-NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 577 -NKQQASFLHLALHNKRKEVVLTII 600
NK + LHLA R V ++
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLV 717
Score = 152 bits (383), Expect = 2e-36
Identities = 129/480 (26%), Positives = 221/480 (46%), Gaps = 27/480 (5%)
Query: 25 VPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLK-RCDDMDTFF-LHYAAAEGQIELMEKI 82
V D T D+ +L V Y + KK ++ F LH A + +I++ME +
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
Query: 83 TRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGM 142
+ + + + + G TP+H A + V L+ GA+PN N LH+A +
Sbjct: 420 LKHGAS--IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
Query: 143 NNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPI 202
EV++ L++ V + ++ T + I+ ++ +Q LL++GA P + G P+
Sbjct: 478 QAEVVRYLVQDGA-QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
Query: 203 HQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNG 262
H +A G ++ +L +HG S ++ TPLH+A + G LE+ + L
Sbjct: 537 HLSAREGHEDVAAFLL----DHGAS----LSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Query: 263 AQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHH 322
A D K T +H AA ++ L++ G+ +G T LH A+ +
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ--GASPHAAAKNGY--TPLHIAAKKNQM 644
Query: 323 ELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLT 382
++A L+ GAD N + +G + + LA ++V+LLL + A V++ + G LHL
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Query: 383 VQQPYGLKNLRPEFMQMQQIKELVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHS 441
Q+ R ++ + +D + G TPLH C G VN LL + +++
Sbjct: 705 AQED------RVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 442 KSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501
K+K+ +PLH AA G + LLQ+ + NE ++G T L +A + G+ VV L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASP---NELTVNGNTALGIARRLGYISVVDTL 815
Score = 145 bits (365), Expect = 3e-34
Identities = 123/484 (25%), Positives = 219/484 (45%), Gaps = 66/484 (13%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
+D+N+ +NG A+ +A + E + LL++ A + K G +H A+ +G E ++
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA------------ 263
+++ G ++N + TPL++A Q LE++K LDNGA
Sbjct: 125 VLVTNG--------ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Query: 264 -----------------QIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ D K R A+H AA + T+ L++ + + D+ + +
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSG 235
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T LH A+ + + +A L++ A ++ +PL +A+ + N+V LLL +GA
Sbjct: 236 ---FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292
Query: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMD-------EDNDGCTPLHY 419
++D K G LH + + +Q+ E+++D + +G +PLH
Sbjct: 293 KIDAKTRDGLTPLHCGARSGH------------EQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
A + V LL NV + + D + LH AA G + LL ++ N
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP---NAKA 397
Query: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGYTQTMKVILDTNL 538
L+G TPLH+A K KV++LLLK GA + +G T +H A+ G+ + ++
Sbjct: 398 LNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 539 KCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLN-KQQASFLHLALHNKRKEVVL 597
+ + G TALH AAR G A+ V L+ A + K + LH++ + ++V
Sbjct: 458 S-PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
Query: 598 TIIR 601
+++
Sbjct: 517 QLLQ 520
Score = 127 bits (319), Expect = 6e-29
Identities = 103/363 (28%), Positives = 164/363 (45%), Gaps = 25/363 (6%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A + G LE + NG I+ + A+H A+ +G E+V ++ +VD T
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAA-TK 105
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
G T LH ASL E+ L++ GA++N G +PL +A +V LL G
Sbjct: 106 KG--NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDG---CTPLHYACR 422
A + G L + +QQ + Q+ L+++ D G LH A R
Sbjct: 164 ASQSLATEDGFTPLAVALQQGH------------DQVVSLLLENDTKGKVRLPALHIAAR 211
Query: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHG 482
+ + LL + + +SK +PLH AA YG IN LL + D+
Sbjct: 212 KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI-- 269
Query: 483 MTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT 541
TPLH+A+K G+ +V+LLL +GA + +G T LH + G+ Q ++++LD
Sbjct: 270 -TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 542 DRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTII 600
+ ++G + LH A + H V LLL HN + + + LH+A H +V ++
Sbjct: 329 SK-TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 601 RSK 603
K
Sbjct: 388 DKK 390
Score = 66.2 bits (160), Expect = 2e-10
Identities = 52/166 (31%), Positives = 87/166 (52%), Gaps = 6/166 (3%)
Query: 442 KSKDKKSPLHFAASY---GRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVV 498
+S+D+K ASY R ++ L I + +N + +G+ LHLA+K GH +VV
Sbjct: 31 RSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV 90
Query: 499 QLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAR 557
LL++ A + + G TALH AS+ G + +KV++ TN + ++G T L+ AA+
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV-TNGANVNAQSQNGFTPLYMAAQ 149
Query: 558 EGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602
E H + V LL + A L + + L +AL +VV ++ +
Sbjct: 150 ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 182 bits (462), Expect = 2e-45
Identities = 150/498 (30%), Positives = 240/498 (48%), Gaps = 31/498 (6%)
Query: 89 EVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMK 148
E ++ D+ TPLH A E ++ L+ GA N ++ + PLH AV + E ++
Sbjct: 32 EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQ 91
Query: 149 VLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFS 208
VLL+H + DVN +N T + IA + + L+ + S++ G +H AAFS
Sbjct: 92 VLLKH-SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFS 150
Query: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268
G E ++++L SR +IN + +H A G +E++K+ + +GA++
Sbjct: 151 GHGEMVKLLL--------SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
Query: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328
+K T +H AA+ G +VK ++ VD +N + T LH A + + L
Sbjct: 203 DKKSYTPLHAAASSGMISVVKYLLDL---GVD-MNEPNAYGNTPLHVACYNGQDVVVNEL 258
Query: 329 ISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387
I GA +N+ + +G +PL A AS + + LL+ GA V++K G+ LH+T
Sbjct: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA---- 314
Query: 388 GLKNLRPEFMQMQQIKE--LVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444
L F + Q I + V+D ED +G TPLH A R G +N L+ +
Sbjct: 315 ----LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
Query: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504
PLH AA G + C++LL D ++ D G T LH AA G+ + + LLL
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFD---IDTPDDFGRTCLHAAAAGGNLECLNLLLNT 427
Query: 505 GALF-LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA-REGHAK 562
GA F D G + LH+A+ Q + ++ + D LDE G T LH+AA + K
Sbjct: 428 GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGK 486
Query: 563 AVALLLSHNADIVLNKQQ 580
+ LL ++A+ + +Q
Sbjct: 487 CLEYLLRNDANPGIRDKQ 504
Score = 166 bits (419), Expect = 1e-40
Identities = 163/582 (28%), Positives = 253/582 (43%), Gaps = 55/582 (9%)
Query: 65 FFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANP 124
F LH AA G + K+ SS + DD+G T LH A +E + LL+ GA+
Sbjct: 374 FPLHLAALSGFSDCCRKLL--SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
Query: 125 NLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTN-NSEALQI 183
N ++ +PLH A N + + L+ VN E G T + A T++ + + L+
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGA-SVNDLDERGCTPLHYAATSDTDGKCLEY 490
Query: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII-------------------------- 217
LL+ A P +K G +H +A G + C+++I
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 218 ---LRFGEEHGYSRQLHI--------NFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQI- 265
L HG+ + L + + N+ TPL LA G +E + + ++ GA I
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 266 --DPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHE 323
D + K T IH AAT G +E ++L+I + + V+ DG +T L + L H +
Sbjct: 611 VKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQ-NAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 324 LADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV 383
L++ GA+++ D GR+ L + V+ LL GA+ ++D+ GR +HL+
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Query: 384 QQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 443
+ + L + DN G T LH+AC G V LL V
Sbjct: 728 ACGH-IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTE 785
Query: 444 KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLK 503
+ SPLH A + L+ D ++N D G TPLH AA H + +QLLL
Sbjct: 786 GNAFSPLHCAVINDNEGAAEMLI-DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844
Query: 504 KGALFLS-DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAK 562
A S D G T L A+ G T T+++++ + D NTALH A +GH
Sbjct: 845 HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 904
Query: 563 AVALLLSHNAD-IVLNKQQASF---LHLALHNKRKEVVLTII 600
+ L+L D ++N A+ LH+A N VV ++
Sbjct: 905 SALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
Score = 164 bits (415), Expect = 4e-40
Identities = 143/531 (26%), Positives = 238/531 (44%), Gaps = 30/531 (5%)
Query: 59 CDDMDTFF-LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117
C D ++ LH AA+ G I ++ K D ++ ++E + YGNTPLH A Q V L
Sbjct: 201 CKDKKSYTPLHAAASSGMISVV-KYLLDLGVD-MNEPNAYGNTPLHVACYNGQDVVVNEL 258
Query: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177
+ GA N +N PLH A + + LL DVN++ ++G T + +
Sbjct: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
Query: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237
Q +++ GA +K G P+H AA G + + ++ G + R +H F
Sbjct: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA-KRGIHGMF--- 374
Query: 238 GKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSG 297
PLHLA +G + + L +G ID + T +H AA G E + L++++ +
Sbjct: 375 ----PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPL-ILATASASWN 356
N D + LH A+ +++ L+ GA +N +D G +PL AT+
Sbjct: 431 ----FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
Query: 357 IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL------KNLRPEFMQMQQIKELVMDED 410
+ LL A I+D G N +H + + L + + +++ D D
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
Query: 411 NDG-CTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI 469
N +PLH A G ++ L+ + + ++ ++PL AA G + L+
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN-- 604
Query: 470 SDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL----KKGALFLSDHNGWTALHHASMGG 525
+L + + TP+H AA NGH + ++LL+ + A+ + D NG T L + + G
Sbjct: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
Query: 526 YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVL 576
+T + +L+ D D+ G TALH A GH + V LL H A +L
Sbjct: 665 HTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL 714
Score = 162 bits (410), Expect = 2e-39
Identities = 151/602 (25%), Positives = 258/602 (42%), Gaps = 71/602 (11%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A G+ + I + + V+ D GNTPLH A + L++ GA+
Sbjct: 310 LHMTALHGRFSRSQTIIQSGA--VIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK 367
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
R + M PLH+A ++ + LL D++ + G T + A N E L +LL
Sbjct: 368 RGIHGMFPLHLAALSGFSDCCRKLLSSG-FDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA K +K+G P+H AA + + +C+ ++ G +N ++ TPLH A
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGAS--------VNDLDERGCTPLHYA 478
Query: 247 VQNG-DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSY--------SG 297
+ D + ++ L N A +K A+H++A G ++L+ S SG
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
+ + ++ + + LH A+ HH+ + L+ D++ +S GR+PL LA
Sbjct: 539 TDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC 598
Query: 358 VNLLLSKGAQVDIKDNF-GRNFLHLTVQQPYG------LKNLRPEFMQMQQIKELVMDED 410
V++L+++GA + +KD R +H + + N P+ V +D
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ--------NAVDIQD 650
Query: 411 NDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK-------------------------- 444
+G TPL + G V +LL ++ +K K
Sbjct: 651 GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
Query: 445 -------DKKSPLHFAASYGRINTCQRLLQDISDTRLLNE-GDLHGMTPLHLAAKNGHDK 496
++P+H +A+ G I LLQ + D HG T LH A NGH+
Sbjct: 711 KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET 770
Query: 497 VVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDT-NLKCTDRLDEDGNTALHFA 555
V+LLL++ ++ N ++ LH A + ++++DT + D G T LH A
Sbjct: 771 CVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830
Query: 556 AREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSH 614
A H + + LLLSHNA + ++ + L +A N + V ++ S + L+ S
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
Query: 615 NS 616
N+
Sbjct: 891 NT 892
Score = 157 bits (398), Expect = 4e-38
Identities = 137/501 (27%), Positives = 230/501 (45%), Gaps = 58/501 (11%)
Query: 105 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGEN 164
A+ + V+ L+ + + N ++ PLH A + E++++L+ VN +
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA-RVNAKDSK 73
Query: 165 GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224
T + A + + EA+Q+LLK A +K P+H AA + + +C E ++
Sbjct: 74 WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL---- 129
Query: 225 GYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284
++N + T LH A +G EM+K+ L GA I+ +K AIH+AA G
Sbjct: 130 ----LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRS 344
E+VKL++S + V D T LH A+ + YL+ +G D+N+ ++ G +
Sbjct: 186 IEVVKLLVSHGAE----VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNT 241
Query: 345 PLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKE 404
PL +A + +VN L+ GA V+ K
Sbjct: 242 PLHVACYNGQDVVVNELIDCGAIVNQK--------------------------------- 268
Query: 405 LVMDEDNDGCTPLHYACRQ-GGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQ 463
+ G TPLH+A G + L+G ++ KSKD K+PLH A +GR + Q
Sbjct: 269 -----NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
Query: 464 RLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHAS 522
++Q +++ D +G TPLH+AA+ GH+ ++ L+ GA +G LH A+
Sbjct: 324 TIIQ---SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Query: 523 MGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQA 581
+ G++ + +L + D D+ G T LH AA G+ + + LLL+ AD +K
Sbjct: 381 LSGFSDCCRKLLSSGFD-IDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 439
Query: 582 SFLHLALHNKRKEVVLTIIRS 602
S LH A N + + ++ S
Sbjct: 440 SPLHYAAANCNYQCLFALVGS 460
Score = 154 bits (390), Expect = 3e-37
Identities = 129/461 (27%), Positives = 219/461 (47%), Gaps = 64/461 (13%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G + +E + + SL L + G TPL A K +E V L+++GA+ +
Sbjct: 554 LHLAAYHGHHQALEVLVQ--SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 127 RNFNMM-APLHIAVQGMNNEVMKVLLEHRTID--VNLEGENGNTAVIIACTTNNSEALQI 183
+++ + P+H A ++E +++L+ + V+++ NG T ++++ +++ +
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPL 243
LL KGA +KWG +H+ A +G +EC++ +L +HG L ++ TP+
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL----QHGAKCLLR----DSRGRTPI 723
Query: 244 HLAVQNGDLEMIKMCLDNGAQIDP----VEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299
HL+ G + ++ L + A +D + TA+H+A G V+L++
Sbjct: 724 HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ----- 778
Query: 300 DIVNTTDGCHETMLHRASLFDHHELADYLI-SVGADI-NKIDSEGRSPLILATASASWNI 357
++ T+G + LH A + D+ A+ LI ++GA I N DS+GR+PL A +
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPL 417
+ LLLS AQV+ D+ G+ TPL
Sbjct: 839 LQLLLSHNAQVNSVDSTGK--------------------------------------TPL 860
Query: 418 HYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476
A G +V L+ + + + K + LH A S G + +L+ I+D L+N
Sbjct: 861 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 920
Query: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWT 516
+ TPLH+AA+NG VVQ LL KGA L+ D NG+T
Sbjct: 921 ATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 180 bits (457), Expect = 6e-45
Identities = 156/536 (29%), Positives = 255/536 (47%), Gaps = 26/536 (4%)
Query: 56 LKRCDDMDTFFLHYAAAEGQIELMEKIT-RDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114
+ C+ LH AA EG + L++++ R SS++ + GNT LH A Q E V
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVV 92
Query: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174
K L+ GAN N ++ N PL++A Q + +V+K LLE+ + + E+G T + +A
Sbjct: 93 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQSTATEDGFTPLAVALQ 151
Query: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234
+++A+ ILL+ K K +H AA + ++L+ ++ +N
Sbjct: 152 QGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 207
Query: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
TPLH+A G++ + + L+ GA +D + T +H A+ +G T +VKL++
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
G +D T DG T LH A+ H ++ + L+ GA + G SPL +A
Sbjct: 268 -GGQID-AKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 323
Query: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ-QPYGLKNLRPEFMQMQQIKELVMDEDNDG 413
V LL A VD LH+ Y + L + + L +G
Sbjct: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL------NG 377
Query: 414 CTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 473
TPLH AC++ + L+ + SI + ++ +P+H AA G +N LLQ+ +
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 474 LLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKV 532
+ N + G T LH+AA+ G +VV+ LL+ GAL T LH AS G T+ +++
Sbjct: 438 VTN---IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 533 ILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN-ADIVLNKQQASFLHLA 587
+L ++ D +G T LH +AREG ++LL A + K+ + LH+A
Sbjct: 495 LLQ-HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549
Score = 179 bits (453), Expect = 2e-44
Identities = 166/565 (29%), Positives = 250/565 (44%), Gaps = 85/565 (15%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G ++ K+ D ++ + D G TPLHCA + V+ LL RGA
Sbjct: 249 LHVASKRGNTNMV-KLLLDRGGQIDAKTRD-GLTPLHCAARSGHDQVVELLLERGAPLLA 306
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHR------TIDV---------------------- 158
R N ++PLH+A QG + E +K LL+H+ T+D
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366
Query: 159 ----NLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
N NG T + IAC N + +++L+K GA + G PIH AAF G +
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 426
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
++L+ G + N T LH+A + G +E+++ L NGA +D + T
Sbjct: 427 LLLLQNGASP--------DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 478
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+H A+ G TEIV+L++ + D TT+G T LH ++ ++A L+ GA
Sbjct: 479 PLHIASRLGKTEIVQLLL-QHMAHPDAA-TTNG--YTPLHISAREGQVDVASVLLEAGAA 534
Query: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHL------------- 381
+ +G +PL +A S ++ LLL + A D G LH+
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 382 ---------TVQQPYGLKNLRPEFMQMQQIKELVM--DEDN----DGCTPLHYACRQGGP 426
T + Y ++ + QMQ L+ E N G TPLH A ++G
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH---GM 483
V LL +IH +K + LH AA ++N L + +D D H G
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGY 708
Query: 484 TPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTD 542
TPL +A G+ K+V LLK+GA + NG+T LH A+ G+T + V+L K +
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PN 767
Query: 543 RLDEDGNTALHFAAREGHAKAVALL 567
+GNTAL A R G+ V L
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTL 792
Score = 174 bits (442), Expect = 3e-43
Identities = 152/572 (26%), Positives = 262/572 (45%), Gaps = 61/572 (10%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ GQ E+++ + ++ + ++ G TPL+ A ++N I+ VK+LL GAN +
Sbjct: 80 LHIASLAGQAEVVKVLVKEGAN--INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 137
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q +N+ + +LLE+ T +G+ A+ IA +++++ +LL+
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 187 KGAKPCKSNKW--------GCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNG 238
+K G P+H AA G+ ++L G ++F
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA--------VDFTARN 244
Query: 239 KATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGS 298
TPLH+A + G+ M+K+ LD G QID + T +H AA G ++V+L++ G+
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGA 302
Query: 299 VDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV 358
+ T +G + LH A+ DH E +L+ A ++ + + + L +A + +
Sbjct: 303 PLLARTKNGL--SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 360
Query: 359 NLLLSKGAQVDIKDNFGRNFLHLTVQQ----------PYGL-------KNLRP----EFM 397
LLL K A + + G LH+ ++ YG L P FM
Sbjct: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
Query: 398 QMQQIKELVMDEDND-------GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
I L++ G T LH A R G V LL + ++++++++PL
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-L 509
H A+ G+ Q LLQ ++ + +G TPLH++A+ G V +LL+ GA L
Sbjct: 481 HIASRLGKTEIVQLLLQHMAHP---DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 537
Query: 510 SDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569
+ G+T LH A+ G K++L D ++G T LH AA + K LLL
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Query: 570 HNAD-IVLNKQQASFLHLALHNKRKEVVLTII 600
A K + LH+A + ++ T++
Sbjct: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Score = 173 bits (438), Expect = 9e-43
Identities = 156/552 (28%), Positives = 247/552 (44%), Gaps = 58/552 (10%)
Query: 85 DSSLEVLHEMDDYGNT---PLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------A 133
+ ++ +L E D G LH A K+ +S LL N ++++ M+
Sbjct: 155 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 214
Query: 134 PLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK 193
PLHIA N V +LL +R V+ NG T + +A N+ +++LL +G +
Sbjct: 215 PLHIAAHYGNVNVATLLL-NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 194 SNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLE 253
+ G P+H AA SG + +E++L G + NG +PLH+A Q +E
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPL-------LARTKNG-LSPLHMAAQGDHVE 325
Query: 254 MIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
+K L + A +D V TA+H AA G + KL++ + N T L
Sbjct: 326 CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPL 381
Query: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
H A + ++ + L+ GA I I G +P+ +A NIV LLL GA D+ +
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 441
Query: 374 FGRNFLHLTV-------------------------QQPYGLKNLRPEFMQMQQIKELVMD 408
G LH+ Q P + + + +Q + + +
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501
Query: 409 ED---NDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRL 465
D +G TPLH + R+G + LL + +K +PLH AA YG ++ + L
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Query: 466 LQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMG 524
LQ + + +G+TPLH+AA + KV LLL+KGA + NG+T LH A+
Sbjct: 562 LQRRAAA---DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618
Query: 525 GYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLN-KQQASF 583
Q +L+ + T+ + + G T LH A++EGH V LLL A+I ++ K +
Sbjct: 619 NQMQIASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 677
Query: 584 LHLALHNKRKEV 595
LHLA + V
Sbjct: 678 LHLAAQEDKVNV 689
Score = 161 bits (407), Expect = 4e-39
Identities = 139/510 (27%), Positives = 226/510 (44%), Gaps = 40/510 (7%)
Query: 90 VLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKV 149
+++ + G TPLH A + LL+RGA + N + PLH+A + N ++K+
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 263
Query: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209
LL+ R ++ + +G T + A + + + +++LL++GA K G P+H AA
Sbjct: 264 LLD-RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 210 SKECMEIILRFGEEHG-----YSRQLHI----------------NFMNNGKA----TPLH 244
EC++ +L+ Y LH+ N +A TPLH
Sbjct: 323 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A + ++++++ + GA I + + T IH AA G IV L++ + S D+ N
Sbjct: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNI 441
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
ET LH A+ E+ L+ GA ++ E ++PL +A+ IV LLL
Sbjct: 442 RG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424
A D G LH++ ++ G ++ ++ L + G TPLH A + G
Sbjct: 499 MAHPDAATTNGYTPLHISARE--GQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYG 553
Query: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL + S K+ +PLH AA Y LL+ + + +G T
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYT 610
Query: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDR 543
PLH+AAK ++ LL GA + G T LH AS G+T + ++LD
Sbjct: 611 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI-HM 669
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNAD 573
+ G T+LH AA+E +L H AD
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGAD 699
Score = 147 bits (372), Expect = 4e-35
Identities = 128/488 (26%), Positives = 223/488 (45%), Gaps = 66/488 (13%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
ID+N +NG A+ +A + +Q LL +G+ + K G +H A+ +G E ++
Sbjct: 34 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 93
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA------------ 263
++++ G +IN + TPL++A Q ++++K L+NGA
Sbjct: 94 VLVKEG--------ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
Query: 264 -----------------QIDPVEKGRCTAIHFAATQGATEIVKLMI-SSYSGSVD---IV 302
+ D K R A+H AA + T+ L++ + ++ V +V
Sbjct: 146 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMV 205
Query: 303 NTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 362
N T T LH A+ + + +A L++ GA ++ G +PL +A+ + N+V LLL
Sbjct: 206 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 265
Query: 363 SKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMD-------EDNDGCT 415
+G Q+D K G LH + + Q+ EL+++ +G +
Sbjct: 266 DRGGQIDAKTRDGLTPLHCAARSGH------------DQVVELLLERGAPLLARTKNGLS 313
Query: 416 PLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLL 475
PLH A + V +LL + + D + LH AA G + LL ++
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--- 370
Query: 476 NEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGYTQTMKVIL 534
N L+G TPLH+A K KV++LL+K GA + +G T +H A+ G+ + ++L
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 430
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRK 593
N D + G TALH AAR G + V LL + A + +++ + LH+A +
Sbjct: 431 Q-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 489
Query: 594 EVVLTIIR 601
E+V +++
Sbjct: 490 EIVQLLLQ 497
Score = 120 bits (301), Expect = 7e-27
Identities = 111/390 (28%), Positives = 170/390 (43%), Gaps = 42/390 (10%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A + G+L+ + L G I+ + A+H AA +G +V+ ++ S SVD T
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSA-TK 74
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
G T LH ASL E+ L+ GA+IN G +PL +A ++V LL G
Sbjct: 75 KG--NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 366 AQVDIKDNFGRNFLHLTVQQPYG------LKN--------------------------LR 393
A G L + +QQ + L+N L+
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 394 PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA 453
+ Q K +V G TPLH A G LL ++ +++ +PLH A
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 252
Query: 454 ASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDH 512
+ G N + LL ++ G+TPLH AA++GHD+VV+LLL++GA L
Sbjct: 253 SKRGNTNMVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Query: 513 NGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
NG + LH A+ G + + +K +L D + D TALH AA GH + LLL A
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
Query: 573 DIVLNKQQA-SFLHLALHNKRKEVVLTIIR 601
+ + LH+A R +V+ +++
Sbjct: 369 NPNARALNGFTPLHIACKKNRIKVMELLVK 398
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 7/118 (5%)
Query: 489 AAKNGH-DKVVQLLLKKGALFLS--DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
AA+ G+ DKVV+ L KG + ++ + NG ALH A+ G+ ++ +L D
Sbjct: 17 AARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSAT 73
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602
+ GNTALH A+ G A+ V +L+ A+I Q + L++A +VV ++ +
Sbjct: 74 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 131
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 180 bits (457), Expect = 6e-45
Identities = 156/536 (29%), Positives = 255/536 (47%), Gaps = 26/536 (4%)
Query: 56 LKRCDDMDTFFLHYAAAEGQIELMEKIT-RDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114
+ C+ LH AA EG + L++++ R SS++ + GNT LH A Q E V
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVV 113
Query: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174
K L+ GAN N ++ N PL++A Q + +V+K LLE+ + + E+G T + +A
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQSTATEDGFTPLAVALQ 172
Query: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234
+++A+ ILL+ K K +H AA + ++L+ ++ +N
Sbjct: 173 QGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
Query: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
TPLH+A G++ + + L+ GA +D + T +H A+ +G T +VKL++
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
G +D T DG T LH A+ H ++ + L+ GA + G SPL +A
Sbjct: 289 -GGQID-AKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ-QPYGLKNLRPEFMQMQQIKELVMDEDNDG 413
V LL A VD LH+ Y + L + + L +G
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL------NG 398
Query: 414 CTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 473
TPLH AC++ + L+ + SI + ++ +P+H AA G +N LLQ+ +
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 474 LLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKV 532
+ N + G T LH+AA+ G +VV+ LL+ GAL T LH AS G T+ +++
Sbjct: 459 VTN---IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 533 ILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN-ADIVLNKQQASFLHLA 587
+L ++ D +G T LH +AREG ++LL A + K+ + LH+A
Sbjct: 516 LLQ-HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Score = 179 bits (453), Expect = 2e-44
Identities = 166/565 (29%), Positives = 250/565 (44%), Gaps = 85/565 (15%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G ++ K+ D ++ + D G TPLHCA + V+ LL RGA
Sbjct: 270 LHVASKRGNTNMV-KLLLDRGGQIDAKTRD-GLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHR------TIDV---------------------- 158
R N ++PLH+A QG + E +K LL+H+ T+D
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 159 ----NLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
N NG T + IAC N + +++L+K GA + G PIH AAF G +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
++L+ G + N T LH+A + G +E+++ L NGA +D + T
Sbjct: 448 LLLLQNGASP--------DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+H A+ G TEIV+L++ + D TT+G T LH ++ ++A L+ GA
Sbjct: 500 PLHIASRLGKTEIVQLLL-QHMAHPDAA-TTNG--YTPLHISAREGQVDVASVLLEAGAA 555
Query: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHL------------- 381
+ +G +PL +A S ++ LLL + A D G LH+
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 382 ---------TVQQPYGLKNLRPEFMQMQQIKELVM--DEDN----DGCTPLHYACRQGGP 426
T + Y ++ + QMQ L+ E N G TPLH A ++G
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH---GM 483
V LL +IH +K + LH AA ++N L + +D D H G
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGY 729
Query: 484 TPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTD 542
TPL +A G+ K+V LLK+GA + NG+T LH A+ G+T + V+L K +
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PN 788
Query: 543 RLDEDGNTALHFAAREGHAKAVALL 567
+GNTAL A R G+ V L
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTL 813
Score = 174 bits (442), Expect = 3e-43
Identities = 152/572 (26%), Positives = 262/572 (45%), Gaps = 61/572 (10%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ GQ E+++ + ++ + ++ G TPL+ A ++N I+ VK+LL GAN +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGAN--INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q +N+ + +LLE+ T +G+ A+ IA +++++ +LL+
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 187 KGAKPCKSNKW--------GCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNG 238
+K G P+H AA G+ ++L G ++F
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA--------VDFTARN 265
Query: 239 KATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGS 298
TPLH+A + G+ M+K+ LD G QID + T +H AA G ++V+L++ G+
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGA 323
Query: 299 VDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV 358
+ T +G + LH A+ DH E +L+ A ++ + + + L +A + +
Sbjct: 324 PLLARTKNGL--SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 359 NLLLSKGAQVDIKDNFGRNFLHLTVQQ----------PYGL-------KNLRP----EFM 397
LLL K A + + G LH+ ++ YG L P FM
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 398 QMQQIKELVMDEDND-------GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
I L++ G T LH A R G V LL + ++++++++PL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-L 509
H A+ G+ Q LLQ ++ + +G TPLH++A+ G V +LL+ GA L
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHP---DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 510 SDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569
+ G+T LH A+ G K++L D ++G T LH AA + K LLL
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Query: 570 HNAD-IVLNKQQASFLHLALHNKRKEVVLTII 600
A K + LH+A + ++ T++
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Score = 173 bits (438), Expect = 9e-43
Identities = 156/552 (28%), Positives = 247/552 (44%), Gaps = 58/552 (10%)
Query: 85 DSSLEVLHEMDDYGNT---PLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------A 133
+ ++ +L E D G LH A K+ +S LL N ++++ M+
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 134 PLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK 193
PLHIA N V +LL +R V+ NG T + +A N+ +++LL +G +
Sbjct: 236 PLHIAAHYGNVNVATLLL-NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 194 SNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLE 253
+ G P+H AA SG + +E++L G + NG +PLH+A Q +E
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPL-------LARTKNG-LSPLHMAAQGDHVE 346
Query: 254 MIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
+K L + A +D V TA+H AA G + KL++ + N T L
Sbjct: 347 CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPL 402
Query: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
H A + ++ + L+ GA I I G +P+ +A NIV LLL GA D+ +
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 374 FGRNFLHLTV-------------------------QQPYGLKNLRPEFMQMQQIKELVMD 408
G LH+ Q P + + + +Q + + +
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 409 ED---NDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRL 465
D +G TPLH + R+G + LL + +K +PLH AA YG ++ + L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 466 LQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMG 524
LQ + + +G+TPLH+AA + KV LLL+KGA + NG+T LH A+
Sbjct: 583 LQRRAAA---DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Query: 525 GYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLN-KQQASF 583
Q +L+ + T+ + + G T LH A++EGH V LLL A+I ++ K +
Sbjct: 640 NQMQIASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 698
Query: 584 LHLALHNKRKEV 595
LHLA + V
Sbjct: 699 LHLAAQEDKVNV 710
Score = 161 bits (407), Expect = 4e-39
Identities = 139/510 (27%), Positives = 226/510 (44%), Gaps = 40/510 (7%)
Query: 90 VLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKV 149
+++ + G TPLH A + LL+RGA + N + PLH+A + N ++K+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209
LL+ R ++ + +G T + A + + + +++LL++GA K G P+H AA
Sbjct: 285 LLD-RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 210 SKECMEIILRFGEEHG-----YSRQLHI----------------NFMNNGKA----TPLH 244
EC++ +L+ Y LH+ N +A TPLH
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A + ++++++ + GA I + + T IH AA G IV L++ + S D+ N
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNI 462
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
ET LH A+ E+ L+ GA ++ E ++PL +A+ IV LLL
Sbjct: 463 RG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424
A D G LH++ ++ G ++ ++ L + G TPLH A + G
Sbjct: 520 MAHPDAATTNGYTPLHISARE--GQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYG 574
Query: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL + S K+ +PLH AA Y LL+ + + +G T
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYT 631
Query: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDR 543
PLH+AAK ++ LL GA + G T LH AS G+T + ++LD
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI-HM 690
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNAD 573
+ G T+LH AA+E +L H AD
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Score = 147 bits (372), Expect = 4e-35
Identities = 128/488 (26%), Positives = 223/488 (45%), Gaps = 66/488 (13%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
ID+N +NG A+ +A + +Q LL +G+ + K G +H A+ +G E ++
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA------------ 263
++++ G +IN + TPL++A Q ++++K L+NGA
Sbjct: 115 VLVKEG--------ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 264 -----------------QIDPVEKGRCTAIHFAATQGATEIVKLMI-SSYSGSVD---IV 302
+ D K R A+H AA + T+ L++ + ++ V +V
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMV 226
Query: 303 NTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 362
N T T LH A+ + + +A L++ GA ++ G +PL +A+ + N+V LLL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 363 SKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMD-------EDNDGCT 415
+G Q+D K G LH + + Q+ EL+++ +G +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGH------------DQVVELLLERGAPLLARTKNGLS 334
Query: 416 PLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLL 475
PLH A + V +LL + + D + LH AA G + LL ++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--- 391
Query: 476 NEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGYTQTMKVIL 534
N L+G TPLH+A K KV++LL+K GA + +G T +H A+ G+ + ++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRK 593
N D + G TALH AAR G + V LL + A + +++ + LH+A +
Sbjct: 452 Q-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 594 EVVLTIIR 601
E+V +++
Sbjct: 511 EIVQLLLQ 518
Score = 120 bits (301), Expect = 7e-27
Identities = 111/390 (28%), Positives = 170/390 (43%), Gaps = 42/390 (10%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A + G+L+ + L G I+ + A+H AA +G +V+ ++ S SVD T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSA-TK 95
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
G T LH ASL E+ L+ GA+IN G +PL +A ++V LL G
Sbjct: 96 KG--NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 366 AQVDIKDNFGRNFLHLTVQQPYG------LKN--------------------------LR 393
A G L + +QQ + L+N L+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 394 PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA 453
+ Q K +V G TPLH A G LL ++ +++ +PLH A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 454 ASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDH 512
+ G N + LL ++ G+TPLH AA++GHD+VV+LLL++GA L
Sbjct: 274 SKRGNTNMVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 513 NGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
NG + LH A+ G + + +K +L D + D TALH AA GH + LLL A
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 573 DIVLNKQQA-SFLHLALHNKRKEVVLTIIR 601
+ + LH+A R +V+ +++
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVK 419
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 7/118 (5%)
Query: 489 AAKNGH-DKVVQLLLKKGALFLS--DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
AA+ G+ DKVV+ L KG + ++ + NG ALH A+ G+ ++ +L D
Sbjct: 38 AARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSAT 94
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602
+ GNTALH A+ G A+ V +L+ A+I Q + L++A +VV ++ +
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 180 bits (457), Expect = 6e-45
Identities = 156/536 (29%), Positives = 255/536 (47%), Gaps = 26/536 (4%)
Query: 56 LKRCDDMDTFFLHYAAAEGQIELMEKIT-RDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114
+ C+ LH AA EG + L++++ R SS++ + GNT LH A Q E V
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVV 113
Query: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174
K L+ GAN N ++ N PL++A Q + +V+K LLE+ + + E+G T + +A
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQSTATEDGFTPLAVALQ 172
Query: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234
+++A+ ILL+ K K +H AA + ++L+ ++ +N
Sbjct: 173 QGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
Query: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
TPLH+A G++ + + L+ GA +D + T +H A+ +G T +VKL++
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
G +D T DG T LH A+ H ++ + L+ GA + G SPL +A
Sbjct: 289 -GGQID-AKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ-QPYGLKNLRPEFMQMQQIKELVMDEDNDG 413
V LL A VD LH+ Y + L + + L +G
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL------NG 398
Query: 414 CTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 473
TPLH AC++ + L+ + SI + ++ +P+H AA G +N LLQ+ +
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 474 LLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKV 532
+ N + G T LH+AA+ G +VV+ LL+ GAL T LH AS G T+ +++
Sbjct: 459 VTN---IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 533 ILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN-ADIVLNKQQASFLHLA 587
+L ++ D +G T LH +AREG ++LL A + K+ + LH+A
Sbjct: 516 LLQ-HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Score = 179 bits (453), Expect = 2e-44
Identities = 166/565 (29%), Positives = 250/565 (44%), Gaps = 85/565 (15%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ G ++ K+ D ++ + D G TPLHCA + V+ LL RGA
Sbjct: 270 LHVASKRGNTNMV-KLLLDRGGQIDAKTRD-GLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHR------TIDV---------------------- 158
R N ++PLH+A QG + E +K LL+H+ T+D
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 159 ----NLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
N NG T + IAC N + +++L+K GA + G PIH AAF G +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
++L+ G + N T LH+A + G +E+++ L NGA +D + T
Sbjct: 448 LLLLQNGASP--------DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+H A+ G TEIV+L++ + D TT+G T LH ++ ++A L+ GA
Sbjct: 500 PLHIASRLGKTEIVQLLL-QHMAHPDAA-TTNG--YTPLHISAREGQVDVASVLLEAGAA 555
Query: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHL------------- 381
+ +G +PL +A S ++ LLL + A D G LH+
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 382 ---------TVQQPYGLKNLRPEFMQMQQIKELVM--DEDN----DGCTPLHYACRQGGP 426
T + Y ++ + QMQ L+ E N G TPLH A ++G
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH---GM 483
V LL +IH +K + LH AA ++N L + +D D H G
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ------DAHTKLGY 729
Query: 484 TPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTD 542
TPL +A G+ K+V LLK+GA + NG+T LH A+ G+T + V+L K +
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PN 788
Query: 543 RLDEDGNTALHFAAREGHAKAVALL 567
+GNTAL A R G+ V L
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTL 813
Score = 174 bits (442), Expect = 3e-43
Identities = 152/572 (26%), Positives = 262/572 (45%), Gaps = 61/572 (10%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A+ GQ E+++ + ++ + ++ G TPL+ A ++N I+ VK+LL GAN +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGAN--INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ PL +A+Q +N+ + +LLE+ T +G+ A+ IA +++++ +LL+
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 187 KGAKPCKSNKW--------GCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNG 238
+K G P+H AA G+ ++L G ++F
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA--------VDFTARN 265
Query: 239 KATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGS 298
TPLH+A + G+ M+K+ LD G QID + T +H AA G ++V+L++ G+
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGA 323
Query: 299 VDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV 358
+ T +G + LH A+ DH E +L+ A ++ + + + L +A + +
Sbjct: 324 PLLARTKNGL--SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 359 NLLLSKGAQVDIKDNFGRNFLHLTVQQ----------PYGL-------KNLRP----EFM 397
LLL K A + + G LH+ ++ YG L P FM
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 398 QMQQIKELVMDEDND-------GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
I L++ G T LH A R G V LL + ++++++++PL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-L 509
H A+ G+ Q LLQ ++ + +G TPLH++A+ G V +LL+ GA L
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHP---DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 510 SDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569
+ G+T LH A+ G K++L D ++G T LH AA + K LLL
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Query: 570 HNAD-IVLNKQQASFLHLALHNKRKEVVLTII 600
A K + LH+A + ++ T++
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Score = 173 bits (438), Expect = 9e-43
Identities = 156/552 (28%), Positives = 247/552 (44%), Gaps = 58/552 (10%)
Query: 85 DSSLEVLHEMDDYGNT---PLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------A 133
+ ++ +L E D G LH A K+ +S LL N ++++ M+
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 134 PLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK 193
PLHIA N V +LL +R V+ NG T + +A N+ +++LL +G +
Sbjct: 236 PLHIAAHYGNVNVATLLL-NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 194 SNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLE 253
+ G P+H AA SG + +E++L G + NG +PLH+A Q +E
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPL-------LARTKNG-LSPLHMAAQGDHVE 346
Query: 254 MIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
+K L + A +D V TA+H AA G + KL++ + N T L
Sbjct: 347 CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPL 402
Query: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
H A + ++ + L+ GA I I G +P+ +A NIV LLL GA D+ +
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 374 FGRNFLHLTV-------------------------QQPYGLKNLRPEFMQMQQIKELVMD 408
G LH+ Q P + + + +Q + + +
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 409 ED---NDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRL 465
D +G TPLH + R+G + LL + +K +PLH AA YG ++ + L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 466 LQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMG 524
LQ + + +G+TPLH+AA + KV LLL+KGA + NG+T LH A+
Sbjct: 583 LQRRAAA---DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Query: 525 GYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLN-KQQASF 583
Q +L+ + T+ + + G T LH A++EGH V LLL A+I ++ K +
Sbjct: 640 NQMQIASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 698
Query: 584 LHLALHNKRKEV 595
LHLA + V
Sbjct: 699 LHLAAQEDKVNV 710
Score = 161 bits (407), Expect = 4e-39
Identities = 139/510 (27%), Positives = 226/510 (44%), Gaps = 40/510 (7%)
Query: 90 VLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKV 149
+++ + G TPLH A + LL+RGA + N + PLH+A + N ++K+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209
LL+ R ++ + +G T + A + + + +++LL++GA K G P+H AA
Sbjct: 285 LLD-RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 210 SKECMEIILRFGEEHG-----YSRQLHI----------------NFMNNGKA----TPLH 244
EC++ +L+ Y LH+ N +A TPLH
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
+A + ++++++ + GA I + + T IH AA G IV L++ + S D+ N
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNI 462
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
ET LH A+ E+ L+ GA ++ E ++PL +A+ IV LLL
Sbjct: 463 RG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424
A D G LH++ ++ G ++ ++ L + G TPLH A + G
Sbjct: 520 MAHPDAATTNGYTPLHISARE--GQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYG 574
Query: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL + S K+ +PLH AA Y LL+ + + +G T
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYT 631
Query: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDR 543
PLH+AAK ++ LL GA + G T LH AS G+T + ++LD
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI-HM 690
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNAD 573
+ G T+LH AA+E +L H AD
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Score = 147 bits (372), Expect = 4e-35
Identities = 128/488 (26%), Positives = 223/488 (45%), Gaps = 66/488 (13%)
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
ID+N +NG A+ +A + +Q LL +G+ + K G +H A+ +G E ++
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA------------ 263
++++ G +IN + TPL++A Q ++++K L+NGA
Sbjct: 115 VLVKEG--------ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 264 -----------------QIDPVEKGRCTAIHFAATQGATEIVKLMI-SSYSGSVD---IV 302
+ D K R A+H AA + T+ L++ + ++ V +V
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMV 226
Query: 303 NTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 362
N T T LH A+ + + +A L++ GA ++ G +PL +A+ + N+V LLL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 363 SKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMD-------EDNDGCT 415
+G Q+D K G LH + + Q+ EL+++ +G +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGH------------DQVVELLLERGAPLLARTKNGLS 334
Query: 416 PLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLL 475
PLH A + V +LL + + D + LH AA G + LL ++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP--- 391
Query: 476 NEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGYTQTMKVIL 534
N L+G TPLH+A K KV++LL+K GA + +G T +H A+ G+ + ++L
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRK 593
N D + G TALH AAR G + V LL + A + +++ + LH+A +
Sbjct: 452 Q-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 594 EVVLTIIR 601
E+V +++
Sbjct: 511 EIVQLLLQ 518
Score = 120 bits (301), Expect = 7e-27
Identities = 111/390 (28%), Positives = 170/390 (43%), Gaps = 42/390 (10%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A + G+L+ + L G I+ + A+H AA +G +V+ ++ S SVD T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSA-TK 95
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
G T LH ASL E+ L+ GA+IN G +PL +A ++V LL G
Sbjct: 96 KG--NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 366 AQVDIKDNFGRNFLHLTVQQPYG------LKN--------------------------LR 393
A G L + +QQ + L+N L+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 394 PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA 453
+ Q K +V G TPLH A G LL ++ +++ +PLH A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 454 ASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDH 512
+ G N + LL ++ G+TPLH AA++GHD+VV+LLL++GA L
Sbjct: 274 SKRGNTNMVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 513 NGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
NG + LH A+ G + + +K +L D + D TALH AA GH + LLL A
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAP-VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 573 DIVLNKQQA-SFLHLALHNKRKEVVLTIIR 601
+ + LH+A R +V+ +++
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVK 419
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 7/118 (5%)
Query: 489 AAKNGH-DKVVQLLLKKGALFLS--DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
AA+ G+ DKVV+ L KG + ++ + NG ALH A+ G+ ++ +L D
Sbjct: 38 AARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSAT 94
Query: 546 EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602
+ GNTALH A+ G A+ V +L+ A+I Q + L++A +VV ++ +
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 170 bits (431), Expect = 6e-42
Identities = 158/600 (26%), Positives = 256/600 (42%), Gaps = 80/600 (13%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH+AA G +E++ + + ++ D LH A ++ V L++ GA
Sbjct: 119 LHHAALNGHVEMVNLLLAKGAN--INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
++ PLH A V+K LL + ++++ GNTA+ IAC + L+
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKE-CMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
GA + N G P+H AA S C+E+++ G + +N + +PLH+
Sbjct: 236 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD--------VNIQSKDGKSPLHM 287
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI---- 301
+G + + NG +ID V+K T +H AA G ++ + +S + +
Sbjct: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHS 347
Query: 302 -------------------------VNTTDGCHETMLHRASLFDHHELADYLISVGADIN 336
++T D T LH A+ + E L S GAD +
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
Query: 337 KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYG-----LKN 391
K D GR+PL A A+ ++ + L++ GA V+ D++GR LH L N
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 392 LRPEFMQMQQIKELVMDE------------------DNDGCTPLHYACRQGGPGSVNNLL 433
++++ +EL E D +G +HYA G + LL
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Query: 434 -----GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488
GF S S KSPLH AA G + LLQ + D L+ D G T L L
Sbjct: 528 ERTNSGFE---ESDSGATKSPLHLAAYNGHHQALEVLLQSLVD---LDIRDEKGRTALDL 581
Query: 489 AAKNGHDKVVQLLLKKGA-LFLSDH-NGWTALHHASMGGYTQTMKVILD--TNLKCTDRL 544
AA GH + V+ L+ GA +F+ D+ T LH + + G+T ++++L+ N + D
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 545 DEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTIIRSK 603
D G T L A GH AV+LLL A++ ++ + LH + +E V ++ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Score = 166 bits (420), Expect = 1e-40
Identities = 131/473 (27%), Positives = 224/473 (47%), Gaps = 30/473 (6%)
Query: 89 EVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMK 148
E ++ +D TPLH A E ++ L+ GA N ++ + PLH AV + E ++
Sbjct: 7 EDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
Query: 149 VLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFS 208
VL++H + DVN +N T + +A + ++++ + S++ G +H AA +
Sbjct: 67 VLIKH-SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALN 125
Query: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268
G E + ++L G +IN + LH A G L+++ + +++GA++
Sbjct: 126 GHVEMVNLLLAKG--------ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328
+K T +H AA+ G +VK ++ + +D +N T LH A + + L
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYG---NTALHIACYNGQDAVVNEL 233
Query: 329 ISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387
I GA++N+ ++ G +PL A AS + + LL++ GA V+I+ G++ LH+T
Sbjct: 234 IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA---- 289
Query: 388 GLKNLRPEFMQMQQIKE---LVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444
+ F + Q + + + D DG TPLH A R G +N L
Sbjct: 290 ----VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGI 345
Query: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504
PLH AA + C++LL S ++ D G T LH AA G+ + ++LL
Sbjct: 346 HSMFPLHLAALNAHSDCCRKLL---SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
Query: 505 GALF-LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA 556
GA F D G T LH+A+ + ++ ++ T + D+ G TALH+AA
Sbjct: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAA 454
Score = 164 bits (415), Expect = 4e-40
Identities = 126/461 (27%), Positives = 221/461 (47%), Gaps = 38/461 (8%)
Query: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK-PCKSNKWGCFPIHQAAFS 208
+L H+T DVN T + +A ++E +++L+ GA+ K N W P+H+A S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVAS 59
Query: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268
S+E ++++++ + +N + TPLH+A N ++ ++ + + ++
Sbjct: 60 RSEEAVQVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS 111
Query: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328
++G TA+H AA G E+V L+++ + +N D LH A+ H ++ L
Sbjct: 112 DRGGRTALHHAALNGHVEMVNLLLAKGAN----INAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 329 ISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYG 388
I+ GA++ D +G +PL A ++ N+V LL+ G ++D + +G LH+
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG-- 225
Query: 389 LKNLRPEFMQMQQIKEL------VMDEDNDGCTPLHYACRQ-GGPGSVNNLLGFNVSIHS 441
Q + EL V +N+G TPLH+A G + L+ ++
Sbjct: 226 ---------QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI 276
Query: 442 KSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501
+SKD KSPLH A +GR Q L+Q+ + + D G TPLH+AA+ GH+ ++ L
Sbjct: 277 QSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTL 333
Query: 502 LKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGH 560
GA + LH A++ ++ + +L + + D D+ G T LH AA G+
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGRTCLHAAAAGGN 392
Query: 561 AKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTII 600
+ + LL S AD +K + LH A N + T++
Sbjct: 393 VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Score = 154 bits (390), Expect = 3e-37
Identities = 165/585 (28%), Positives = 254/585 (43%), Gaps = 89/585 (15%)
Query: 58 RCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117
+C F LH AA + K+ SS + D +G T LH A +E +K L
Sbjct: 342 KCGIHSMFPLHLAALNAHSDCCRKLL--SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTN- 176
S GA+ + ++ PLH A + ++ L+ +VN + G TA+ A ++
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA-NVNETDDWGRTALHYAAASDM 458
Query: 177 ------------NSE---------------ALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209
NSE L+ LL+ A P +K G IH AA G
Sbjct: 459 DRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYG 518
Query: 210 SKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQID-PV 268
++C+E++L G+ + +PLHLA NG + +++ L + +D
Sbjct: 519 HRQCLELLLE-RTNSGFEES-----DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328
EKGR TA+ AA +G TE V+ +I+ + N T T LH AS+ + H L L
Sbjct: 573 EKGR-TALDLAAFKGHTECVEALINPGASIFVKDNVTK---RTPLH-ASVINGHTLCLRL 627
Query: 329 ISVGAD----INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ 384
+ AD ++ D++G++PL+LA A + V+LLL K A VD D G LH
Sbjct: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR--- 684
Query: 385 QPYGLKNLRPEFMQMQQIKEL-VMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHS-- 441
G+ E +QM +E+ ++ +D+ G TPLHYA +G ++ LL +S
Sbjct: 685 ---GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCC 741
Query: 442 -KSKDKKSPLHFAASYGRIN-------------------------------TCQRLLQDI 469
K +PLH+A G N C LL
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGA 801
Query: 470 SDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQ 528
D+ +++ D G TPL AA H + +QLLL+ A + D++G TAL A+ G
Sbjct: 802 IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAG 861
Query: 529 TMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
+ +++++ D+D NT LH A +GH K L+L D
Sbjct: 862 AVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906
Score = 102 bits (254), Expect = 2e-21
Identities = 123/529 (23%), Positives = 208/529 (39%), Gaps = 121/529 (22%)
Query: 49 NFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAV-- 106
+F+K+ K R LHYAAA +E + + ++E DD+G T LH A
Sbjct: 405 DFHKKDKCGRTP------LHYAAANCHFHCIETLVTTGAN--VNETDDWGRTALHYAAAS 456
Query: 107 --------------------------EKNQIESVKFLLSRGANPNLRN---FNMM----- 132
EK ++FLL ANP++R+ +N +
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
Query: 133 ---------------------------APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENG 165
+PLH+A +++ ++VLL+ +D+++ E G
Sbjct: 517 YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS-LVDLDIRDEKG 575
Query: 166 NTAVIIACTTNNSEALQILLKKGAKP-CKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224
TA+ +A ++E ++ L+ GA K N P+H + +G C+ ++L +
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635
Query: 225 GYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284
++ + TPL LAV G ++ + + L+ A +D V+ CTA+H G
Sbjct: 636 EA-----VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGA---DINKIDSE 341
E V++++ V I+ D T LH A+ H L+ + D D++
Sbjct: 691 EECVQMLLEQ---EVSIL-CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ 746
Query: 342 GRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNF--LHLTVQQPYG----------- 388
G +PL A + + N + +LL Q + G F LH + +G
Sbjct: 747 GYTPLHWACYNGNENCIEVLLE---QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAID 803
Query: 389 --LKNLRPE----------FMQMQQIKELVMDE-------DNDGCTPLHYACRQGGPGSV 429
+ + R + F + +L++ DN G T L A G G+V
Sbjct: 804 SSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAV 863
Query: 430 NNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
+ L+ + K KD +PLH A S G +L I D L+NE
Sbjct: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
Score = 102 bits (253), Expect = 3e-21
Identities = 94/312 (30%), Positives = 147/312 (47%), Gaps = 14/312 (4%)
Query: 302 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361
VNT D T LH A+ E+ + LI GA +N D+ +PL A AS S V +L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421
+ A V+ +D + LH+ K ++ + + + V D G T LH+A
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAAN----KAVKCAEVIIPLLSS-VNVSDRGGRTALHHAA 123
Query: 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 481
G VN LL +I++ K + LH+AA G ++ L+ ++ D
Sbjct: 124 LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC---KDKK 180
Query: 482 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN--GWTALHHASMGGYTQTMKVILDTNLK 539
G TPLH AA NG VV+ LL G + + + N G TALH A G + ++D
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 540 CTDRLDEDGNTALHFAAREGH-AKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVL 597
++ + +G T LHFAA H A + LL+++ AD+ + +K S LH+ + R
Sbjct: 240 -VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 598 TIIRSKRWDECL 609
T+I++ +C+
Sbjct: 299 TLIQNGGEIDCV 310
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 165 bits (417), Expect = 3e-40
Identities = 159/565 (28%), Positives = 245/565 (43%), Gaps = 64/565 (11%)
Query: 51 NKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQ 110
NK L CD + LH+AA G +E+++ + + + YG LH A Q
Sbjct: 161 NKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGL--LHTAAASGQ 218
Query: 111 IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAV- 169
IE VK+LL GA + N LHIA + + + + L + +VN + G T +
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACY-LGQDAVAIELVNAGANVNQPNDKGFTPLH 277
Query: 170 IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQ 229
+ A +TN + L++L+ GA +K G P+H AA G +I+++ G E
Sbjct: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE------ 331
Query: 230 LHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKG--RCTAIHFAATQGATEI 287
I+ + TPLH+A + G +I + NGA D +G +H A G ++
Sbjct: 332 --IDCADKFGNTPLHVAARYGHELLISTLMTNGA--DTARRGIHDMFPLHLAVLFGFSDC 387
Query: 288 VKLMISS---------------YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVG 332
+ ++SS S DI NT D T LH A+ + E + L+S G
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFDI-NTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
Query: 333 ADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV--------- 383
AD+ + D GR+PL A A+ S+ L++ GA V+ D G + LH
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
Query: 384 -----------QQPYGLKNLRPEFMQMQQIKELVMD---EDNDGCTPLHYACRQGGPGSV 429
+P + F ++ + + D D G T +HYA G ++
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566
Query: 430 NNLL--GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLH 487
LL FN +S SPLH AA G + L + + + L+ D G T L
Sbjct: 567 ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN---LDVRDHKGRTALF 623
Query: 488 LAAKNGHDKVVQLLLKKG--ALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC--TDR 543
LA + G + V++L G AL WT LH A+ G+T ++ +++D+ + TD
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
Query: 544 LDEDGNTALHFAAREGHAKAVALLL 568
+D G T L A GH V LLL
Sbjct: 684 MDAYGQTPLMLAIMNGHVDCVHLLL 708
Score = 151 bits (381), Expect = 4e-36
Identities = 152/586 (25%), Positives = 254/586 (43%), Gaps = 69/586 (11%)
Query: 60 DDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLS 119
D++ LH AA+ G +E + + SS L D +G TPLH A + L++
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLL--SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Query: 120 RGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSE 179
GA N + +PLH A ++ + H + E + + E
Sbjct: 478 AGAGVNEADCKGCSPLHYAAA---SDTYRRAEPHTPSSHDAEEDEPLKE------SRRKE 528
Query: 180 A---LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMN 236
A L+ LL GA P ++ G +H AA G+++ +E++L ++ N +
Sbjct: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL----------EMSFNCLE 578
Query: 237 NGKAT----PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMI 292
+ ++T PLHLA NG E +K + +D + TA+ A +G+TE V+++
Sbjct: 579 DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638
Query: 293 SSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVG--ADINKI-DSEGRSPLILA 349
+ G+ ++ T LH A+ H + LI G ADI + D+ G++PL+LA
Sbjct: 639 AH--GASALIKERKR-KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLA 695
Query: 350 TASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV-------------------------Q 384
+ + V+LLL KG+ D D GR LH +
Sbjct: 696 IMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR 755
Query: 385 QPYGLKN-------LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNV 437
P L + LR L D G +P+H+A G + LL +
Sbjct: 756 TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815
Query: 438 SIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKV 497
+ + + +PLH A + +T + LL + +++N D G TPLH AA +
Sbjct: 816 FSYLEG-NPFTPLHCAVINNQDSTTEMLLGALG-AKIVNSRDAKGRTPLHAAAFADNVSG 873
Query: 498 VQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA 556
+++LL+ A + +DH G TAL A+ G T ++ +L LDE+ NTALH A
Sbjct: 874 LRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLAC 933
Query: 557 REGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRS 602
+GH K ++L+ D+ L S L + LH + + +++++
Sbjct: 934 SKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQA 979
Score = 149 bits (377), Expect = 1e-35
Identities = 134/491 (27%), Positives = 219/491 (44%), Gaps = 42/491 (8%)
Query: 86 SSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNE 145
S E ++ +D TPLH A + ++ LL GAN N ++ + PLH A N +
Sbjct: 29 SQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEK 88
Query: 146 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
V+ +LL H + DVN + T + +A ++ + L + +++ G +H A
Sbjct: 89 VLGLLLAH-SADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 147
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQI 265
SG E + ++L G +N + + PLH A G LE++K+ + GA +
Sbjct: 148 VHSGHLETVNLLLNKGAS--------LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 266 DPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELA 325
++ +H AA G E+VK ++ +D N T LH A +A
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLL-RMGAEIDEPNAFG---NTALHIACYLGQDAVA 255
Query: 326 DYLISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQ 384
L++ GA++N+ + +G +PL +A S + + + LL++ GA V+ + G++ LH+
Sbjct: 256 IELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA- 314
Query: 385 QPYGLKNLRPEFMQMQ---QIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHS 441
+ F + Q Q + D G TPLH A R G ++ L+
Sbjct: 315 -------IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
Query: 442 KSKDKKSPLHFAASYGRINTCQRLL---------QDISDTRLLNEG------DLHGMTPL 486
+ PLH A +G + C++LL +S+ +L+ G D G T L
Sbjct: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427
Query: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
H AA G+ + + LLL GA L D G T LH+A+ G Q V L T + D
Sbjct: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQ-CAVTLVTAGAGVNEAD 486
Query: 546 EDGNTALHFAA 556
G + LH+AA
Sbjct: 487 CKGCSPLHYAA 497
Score = 135 bits (340), Expect = 2e-31
Identities = 126/489 (25%), Positives = 221/489 (45%), Gaps = 45/489 (9%)
Query: 134 PLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK 193
PL A+ + E ++ LL + ++N+ + T + A + LQ+LL GA
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 194 SNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLE 253
+ P+H+AA S +++ + ++L + +N + TPLH+A N +
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSAD--------VNARDKLWQTPLHVAAANRATK 121
Query: 254 MIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
+ + ++ ++ +A+H A G E V L+++ + +N D L
Sbjct: 122 CAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGAS----LNVCDKKERQPL 177
Query: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
H A+ H E+ L++ GAD+ D +G L A AS +V LL GA++D +
Sbjct: 178 HWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNA 237
Query: 374 FGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELV-MDEDND-GCTPLHYAC-RQGGPGSVN 430
FG LH+ L + + ++ + +++ ND G TPLH A G +
Sbjct: 238 FGNTALHIACY-------LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLE 290
Query: 431 NLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAA 490
L+ ++ +SK+ KSPLH AA +GR Q L+Q+ S+ ++ D G TPLH+AA
Sbjct: 291 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE---IDCADKFGNTPLHVAA 347
Query: 491 KNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT-------- 541
+ GH+ ++ L+ GA + LH A + G++ + +L + +
Sbjct: 348 RYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE 407
Query: 542 ---------DRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNK 591
+ D G T LH AA G+ + + LLLS AD+ +K + LH A N
Sbjct: 408 HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
Query: 592 RKEVVLTII 600
+ +T++
Sbjct: 468 SYQCAVTLV 476
Score = 112 bits (279), Expect = 3e-24
Identities = 137/547 (25%), Positives = 224/547 (40%), Gaps = 99/547 (18%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LHYAAA E T S H+ ++ + PL + K ++FLL GA+P+L
Sbjct: 493 LHYAAASDTYRRAEPHTPSS-----HDAEE--DEPLKESRRKEAFFCLEFLLDNGADPSL 545
Query: 127 RN--------------------------FNMM---------APLHIAVQGMNNEVMKVLL 151
R+ FN + +PLH+A + E +K L
Sbjct: 546 RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLA 605
Query: 152 EHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC---KSNKWGCFPIHQAAFS 208
E +++++ G TA+ +A ++E +++L GA + KW P+H AA S
Sbjct: 606 E-TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWT--PLHAAAAS 662
Query: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268
G + + +++ GE + + M+ TPL LA+ NG ++ + + L+ G+ D
Sbjct: 663 GHTDSLHLLIDSGERADIT-----DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717
Query: 269 E----------------------------------KGRCTAIHFAATQGATEIVKLMISS 294
+ KGR T IH A+ G T +++ ++ +
Sbjct: 718 DLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASACGHTAVLRTLLQA 776
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
+ + D + +H AS H + + L+ + + ++ +PL A +
Sbjct: 777 ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQ 835
Query: 355 WNIVNLLLSK-GAQ-VDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDND 412
+ +LL GA+ V+ +D GR LH + LR M +Q E V D+
Sbjct: 836 DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD-NVSGLR---MLLQHQAE-VNATDHT 890
Query: 413 GCTPLHYACRQGGPGSVNNLL-GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
G T L A G +V LL + ++K + LH A S G +L + D
Sbjct: 891 GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWT-ALHHASMGGYTQT 529
L+N + PLH+AA+NG VVQ LL GA L+ D G T AL A
Sbjct: 951 LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADC 1010
Query: 530 MKVILDT 536
+ +IL T
Sbjct: 1011 LALILST 1017
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 162 bits (409), Expect = 2e-39
Identities = 158/568 (27%), Positives = 258/568 (45%), Gaps = 32/568 (5%)
Query: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
G+ G + D P+ S+ + +A L K + +DT L A
Sbjct: 156 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-KAENSHNAGQVDTRSLAEAC 213
Query: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR-NFN 130
++G + + K+ + ++E + G + L A E + LL+ AN R N
Sbjct: 214 SDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 131 MMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
+ PL A G +++K+LL H DVN + GNTA+ AC + +++LL +GA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
N+ G P+ +AA +G E ++L +HG H N K + L LA G
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINTH---SNEFKESALTLACYKG 383
Query: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
L+M++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 439
Query: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
+ L A+ H ELA LI GA++ +++ EG +PL+ A +V LLL++GA ++
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 500 QTEETQETA-LTLACCGGFSEVADFLIKAGADIEL-------GCSTPLMEASQEGHLELV 551
Query: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 608
Query: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
A+ GH VQ L+ KGA + +N T + A GG+ ++++L T RL +D
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL-KD 667
Query: 548 GNTALHFAAREGHAKAVALLLSHNADIV 575
G+T L AA+ GH V+ LL + +++
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVL 695
Score = 94.0 bits (232), Expect = 7e-19
Identities = 101/413 (24%), Positives = 180/413 (43%), Gaps = 37/413 (8%)
Query: 111 IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAV 169
I +V + G+N + + + P + N + + ++D++ E N +TA+
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
Query: 170 IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIIL-RFGEEHGYSR 228
+AC + E + +L+ + AK +K G P+ AA +G +EI+L + G+ S
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 229 QLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIV 288
+ K TPL LA G E++ + L GA + T + AA+ G I+
Sbjct: 1120 RT--------KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 289 KLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADIN-KIDSEGRSPLI 347
K+++++ + + G ML A++ H L+ +G+DIN +I++ + L
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLML--AAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 348 LATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVM 407
LA +V+LLL + A V+ + G L Y ++ +++
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA------------EVGRVLL 1277
Query: 408 DEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR 458
D+ D P L A +G L+ I ++K +PL A++ G
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 459 INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSD 511
+ Q L+Q +D ++ D +TPL A + GH KVVQ L+K+ F SD
Sbjct: 1338 FDVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD 1387
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
SVDI T+ H+T L A H EL LI+ A I D +G +PLILA + +
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
Query: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414
V +LL KG ++ + T P L R E + + + + N
Sbjct: 1104 VEILLDKGGDIEAQS-------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
Query: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472
TPL A G + LL I+S++ K SPL AA G + + LL SD
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 473 RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531
E + + T L LA G +VV LLL +K + G T L A+ GGY + +
Sbjct: 1217 NAQIETNRN--TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 532 VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
V+LD + +TAL AA +GH K LL+ A I V NK+ + L LA +
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 590 NKRKEVVLTIIRS 602
+VV ++++
Sbjct: 1335 GGHFDVVQLLVQA 1347
Score = 90.9 bits (224), Expect = 6e-18
Identities = 84/322 (26%), Positives = 142/322 (44%), Gaps = 44/322 (13%)
Query: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
S+++ + +T L A E V L++R A R+ PL +A + V
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
Query: 147 MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
+++LL+ + D+ + E +T + +AC+ E + +LL +GA N P+ A
Sbjct: 1104 VEILLD-KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263
A G ++I+L G E IN K +PL LA NG + +K+ LD G+
Sbjct: 1163 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 264 QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309
I+ +E R TA+ A QG E+V L++ + +G ++ G +
Sbjct: 1215 DINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 310 ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+T L A+ H++ + LI GA I+ + +G +PL LA+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 352 SASWNIVNLLLSKGAQVDIKDN 373
+++V LL+ GA VD DN
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADN 1356
Score = 90.9 bits (224), Expect = 6e-18
Identities = 95/371 (25%), Positives = 167/371 (45%), Gaps = 18/371 (4%)
Query: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
T L LA G E++ + + A+I+ +K T + AAT G +V++++ D
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG---D 1113
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
I ++ +T L A E+ D L++ GA+ + +PL LA + NI+ +
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
LL+ GA+++ + L + G ++ + + ++ + + T L A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ---DISDTRLLNE 477
C QG V+ LL ++ ++K +PL AAS G + LL D++ + +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDT 536
D T L +AA GH K +LL+ +GA + + + G T L AS GG+ +++++
Sbjct: 1292 RD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH----NADIVLNKQQASFLHLALHNKR 592
D D T L A R+GH K V L+ +DI + A+ L K
Sbjct: 1348 GAD-VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKC 1406
Query: 593 KEVVLTIIRSK 603
+ V TI+++K
Sbjct: 1407 HQCVETIVKAK 1417
Score = 81.3 bits (199), Expect = 5e-15
Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A +GD+ ++ LD G ++ + + + A + G E+ +++++ ++ D N
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L AS + ++ L+ AD+N + G + L A A +IV +LL++G
Sbjct: 272 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 329 ANIE--------------------------------------DHNENGHTPLMEAASAGH 350
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G ++ + LL+ +D + ++H T
Sbjct: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 407
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 466
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL+ A+I ++ L L
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Score = 73.6 bits (179), Expect = 1e-12
Identities = 62/256 (24%), Positives = 113/256 (44%), Gaps = 33/256 (12%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L A + G+ E+++ + + + + DY TPL A + +K LL+ GA N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 127 RNFNMM--APLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQI 183
R + + +PL +A + +K+LL+ + D+N + E N NTA+ +AC +E + +
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHG------------------ 225
LL + A K G P+ +AA G E ++L G +
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 226 ---------YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276
R HI+ N TPL LA G +++++ + GA +D + + T +
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 277 HFAATQGATEIVKLMI 292
A +G ++V+ ++
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 39.3 bits (90), Expect = 0.021
Identities = 40/187 (21%), Positives = 74/187 (39%), Gaps = 35/187 (18%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L AA G + + K+ D ++ +++ NT L A + + E V LL R AN
Sbjct: 1194 LMLAAMNGHVPAV-KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLE---------------------------------- 152
R + PL A G EV +VLL+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
Query: 153 HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 212
HR +++ + GNT + +A + + +Q+L++ GA ++ P+ A G +
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
Query: 213 CMEIILR 219
++ +++
Sbjct: 1373 VVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 162 bits (409), Expect = 2e-39
Identities = 158/568 (27%), Positives = 258/568 (45%), Gaps = 32/568 (5%)
Query: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
G+ G + D P+ S+ + +A L K + +DT L A
Sbjct: 156 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-KAENSHNAGQVDTRSLAEAC 213
Query: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR-NFN 130
++G + + K+ + ++E + G + L A E + LL+ AN R N
Sbjct: 214 SDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 131 MMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
+ PL A G +++K+LL H DVN + GNTA+ AC + +++LL +GA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
N+ G P+ +AA +G E ++L +HG H N K + L LA G
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINTH---SNEFKESALTLACYKG 383
Query: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
L+M++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 439
Query: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
+ L A+ H ELA LI GA++ +++ EG +PL+ A +V LLL++GA ++
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 500 QTEETQETA-LTLACCGGFSEVADFLIKAGADIEL-------GCSTPLMEASQEGHLELV 551
Query: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 608
Query: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
A+ GH VQ L+ KGA + +N T + A GG+ ++++L T RL +D
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL-KD 667
Query: 548 GNTALHFAAREGHAKAVALLLSHNADIV 575
G+T L AA+ GH V+ LL + +++
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVL 695
Score = 94.0 bits (232), Expect = 7e-19
Identities = 101/413 (24%), Positives = 180/413 (43%), Gaps = 37/413 (8%)
Query: 111 IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAV 169
I +V + G+N + + + P + N + + ++D++ E N +TA+
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
Query: 170 IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIIL-RFGEEHGYSR 228
+AC + E + +L+ + AK +K G P+ AA +G +EI+L + G+ S
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 229 QLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIV 288
+ K TPL LA G E++ + L GA + T + AA+ G I+
Sbjct: 1120 RT--------KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 289 KLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADIN-KIDSEGRSPLI 347
K+++++ + + G ML A++ H L+ +G+DIN +I++ + L
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLML--AAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 348 LATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVM 407
LA +V+LLL + A V+ + G L Y ++ +++
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA------------EVGRVLL 1277
Query: 408 DEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR 458
D+ D P L A +G L+ I ++K +PL A++ G
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 459 INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSD 511
+ Q L+Q +D ++ D +TPL A + GH KVVQ L+K+ F SD
Sbjct: 1338 FDVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD 1387
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
SVDI T+ H+T L A H EL LI+ A I D +G +PLILA + +
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
Query: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414
V +LL KG ++ + T P L R E + + + + N
Sbjct: 1104 VEILLDKGGDIEAQS-------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
Query: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472
TPL A G + LL I+S++ K SPL AA G + + LL SD
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 473 RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531
E + + T L LA G +VV LLL +K + G T L A+ GGY + +
Sbjct: 1217 NAQIETNRN--TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 532 VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
V+LD + +TAL AA +GH K LL+ A I V NK+ + L LA +
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 590 NKRKEVVLTIIRS 602
+VV ++++
Sbjct: 1335 GGHFDVVQLLVQA 1347
Score = 90.9 bits (224), Expect = 6e-18
Identities = 84/322 (26%), Positives = 142/322 (44%), Gaps = 44/322 (13%)
Query: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
S+++ + +T L A E V L++R A R+ PL +A + V
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
Query: 147 MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
+++LL+ + D+ + E +T + +AC+ E + +LL +GA N P+ A
Sbjct: 1104 VEILLD-KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263
A G ++I+L G E IN K +PL LA NG + +K+ LD G+
Sbjct: 1163 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 264 QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309
I+ +E R TA+ A QG E+V L++ + +G ++ G +
Sbjct: 1215 DINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 310 ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+T L A+ H++ + LI GA I+ + +G +PL LA+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 352 SASWNIVNLLLSKGAQVDIKDN 373
+++V LL+ GA VD DN
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADN 1356
Score = 90.9 bits (224), Expect = 6e-18
Identities = 95/371 (25%), Positives = 167/371 (45%), Gaps = 18/371 (4%)
Query: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
T L LA G E++ + + A+I+ +K T + AAT G +V++++ D
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG---D 1113
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
I ++ +T L A E+ D L++ GA+ + +PL LA + NI+ +
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
LL+ GA+++ + L + G ++ + + ++ + + T L A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ---DISDTRLLNE 477
C QG V+ LL ++ ++K +PL AAS G + LL D++ + +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDT 536
D T L +AA GH K +LL+ +GA + + + G T L AS GG+ +++++
Sbjct: 1292 RD----TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH----NADIVLNKQQASFLHLALHNKR 592
D D T L A R+GH K V L+ +DI + A+ L K
Sbjct: 1348 GAD-VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKC 1406
Query: 593 KEVVLTIIRSK 603
+ V TI+++K
Sbjct: 1407 HQCVETIVKAK 1417
Score = 81.3 bits (199), Expect = 5e-15
Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A +GD+ ++ LD G ++ + + + A + G E+ +++++ ++ D N
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L AS + ++ L+ AD+N + G + L A A +IV +LL++G
Sbjct: 272 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 329 ANIE--------------------------------------DHNENGHTPLMEAASAGH 350
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G ++ + LL+ +D + ++H T
Sbjct: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 407
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 466
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL+ A+I ++ L L
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Score = 73.6 bits (179), Expect = 1e-12
Identities = 62/256 (24%), Positives = 113/256 (44%), Gaps = 33/256 (12%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L A + G+ E+++ + + + + DY TPL A + +K LL+ GA N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 127 RNFNMM--APLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQI 183
R + + +PL +A + +K+LL+ + D+N + E N NTA+ +AC +E + +
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHG------------------ 225
LL + A K G P+ +AA G E ++L G +
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 226 ---------YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276
R HI+ N TPL LA G +++++ + GA +D + + T +
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 277 HFAATQGATEIVKLMI 292
A +G ++V+ ++
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 39.3 bits (90), Expect = 0.021
Identities = 40/187 (21%), Positives = 74/187 (39%), Gaps = 35/187 (18%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L AA G + + K+ D ++ +++ NT L A + + E V LL R AN
Sbjct: 1194 LMLAAMNGHVPAV-KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLE---------------------------------- 152
R + PL A G EV +VLL+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
Query: 153 HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 212
HR +++ + GNT + +A + + +Q+L++ GA ++ P+ A G +
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
Query: 213 CMEIILR 219
++ +++
Sbjct: 1373 VVQYLVK 1379
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 160 bits (406), Expect = 5e-39
Identities = 157/563 (27%), Positives = 250/563 (44%), Gaps = 32/563 (5%)
Query: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
G+ G + D P+ S+ + +A L + + D L A
Sbjct: 185 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-RAESTANAGQSDNRSLAEAC 242
Query: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNM 131
+EG + + K+ + ++E + G + L A E + LL+ AN R
Sbjct: 243 SEGDVNAVRKLLIEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 132 -MAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
+ PL A G + +++K+LL H+ DVN + GNTA+ AC + +++LL+ GA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
Query: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
N+ G P+ +A +G E ++L E+G H N K + L LA G
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLL----ENGAGINTH---SNEFKESALTLACYKG 412
Query: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
LEM++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 468
Query: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
+ L A+ H ELA LI GA + +++ EG +PL+ A +V LLL +GA ++
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 529 QTEETQE-TALTLACCGGFLEVADFLIKAGADIEL-------GCSTPLMEAAQEGHLELV 580
Query: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 637
Query: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
A+ GH VQ L+ KGA + +N T L A GG+ ++++L T RL +D
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL-KD 696
Query: 548 GNTALHFAAREGHAKAVALLLSH 570
G+T L AA+ GH V LL +
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDY 719
Score = 121 bits (304), Expect = 3e-27
Identities = 127/454 (27%), Positives = 212/454 (46%), Gaps = 34/454 (7%)
Query: 140 QGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK-PCKSNKWG 198
+G N V K+L+E R+ VN E G + + +AC+ E Q+LL A + K
Sbjct: 244 EGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 199 CFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMC 258
P+ AA G + ++++L + + +N ++ T L A G ++++K+
Sbjct: 302 ITPLMAAANGGHVKIVKLLL--------AHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 259 LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT-TDGCHETMLHRAS 317
L++GA I+ + T + A + G E+ +L++ + +G +NT ++ E+ L A
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAG----INTHSNEFKESALTLAC 409
Query: 318 LFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIK-DNFGR 376
H E+ +L+ GAD E + L+ A + LLL GAQV++ D+F
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 377 NFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFN 436
LT+ G L ++ E V DE G TPL A R+G V LLG
Sbjct: 470 P---LTLAACGGHVELAALLIERGASLEEVNDE---GYTPLMEAAREGHEEMVALLLGQG 523
Query: 437 VSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
+I++++++ +++ L A G + L++ +D +L TPL AA+ GH
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADI------ELGCSTPLMEAAQEGHL 577
Query: 496 KVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHF 554
++V+ LL GA + + G TAL +A G+T V+L + E G T L
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL-EHESEGGRTPLMK 636
Query: 555 AAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
AAR GH V L+S A++ N+ A+ H L
Sbjct: 637 AARAGHVCTVQFLISKGANV--NRTTANNDHTVL 668
Score = 101 bits (251), Expect = 5e-21
Identities = 98/367 (26%), Positives = 167/367 (45%), Gaps = 35/367 (9%)
Query: 156 IDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
ID++ + E N +TA+ +AC + E +Q LL++GA +K G P+ AA +G +
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
EI+L G + + K TPL LA G E++++ L GA + T
Sbjct: 1133 EILLDNGADIEAQSE-------RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 1185
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+ AA+ G I+K+++++ + + G ML A++ H L+ +G+D
Sbjct: 1186 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML--AAMNGHTAAVKLLLDMGSD 1243
Query: 335 IN-KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
IN +I++ + L LA +V+LLL + A V+ + G L Y
Sbjct: 1244 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA----- 1298
Query: 394 PEFMQMQQIKELVMDEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSK 444
++ +++D+ D P L A +G L+G I ++K
Sbjct: 1299 -------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
Query: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504
+PL AA+ G ++ Q L+Q +D ++ D +TPL A + GH KVV+ L+K+
Sbjct: 1352 KGNTPLWLAANGGHLDVVQLLVQAGAD---VDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Query: 505 GALFLSD 511
F SD
Sbjct: 1409 VNQFPSD 1415
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/322 (26%), Positives = 144/322 (44%), Gaps = 44/322 (13%)
Query: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
++++ + + +T L A E V+ LL RGA+ R+ PL +A + V
Sbjct: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
Query: 147 MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
+++LL++ D+ + E +T + +AC+ E +++LL +GA N P+ A
Sbjct: 1132 VEILLDNGA-DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263
A G ++I+L G E IN K +PL LA NG +K+ LD G+
Sbjct: 1191 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
Query: 264 QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309
I+ +E R TA+ A QG TE+V L++ + +G ++ G +
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
Query: 310 ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+T L A+ H++ + LI GA I+ + +G +PL LA
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
Query: 352 SASWNIVNLLLSKGAQVDIKDN 373
++V LL+ GA VD DN
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADN 1384
Score = 93.6 bits (231), Expect = 9e-19
Identities = 94/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
++DI T+ H+T L A H EL L+ GA I D +G +PLILA + +
Sbjct: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
Query: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414
V +LL GA ++ + T P L R E +++ + + N
Sbjct: 1132 VEILLDNGADIEAQS-------ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 1184
Query: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472
TPL A G + LL I+S++ K SPL AA G + LL SD
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 473 RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531
E + + T L LA G +VV LLL +K + G T L A+ GGY + +
Sbjct: 1245 NAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
Query: 532 VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
V+LD + +TAL AA +GH K LL+ A I V NK+ + L LA +
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
Query: 590 NKRKEVVLTIIRS 602
+VV ++++
Sbjct: 1363 GGHLDVVQLLVQA 1375
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/332 (26%), Positives = 151/332 (45%), Gaps = 14/332 (4%)
Query: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
T L LA G E+++ L+ GA I+ +K T + AAT G +V++++ + D
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN---GAD 1141
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
I ++ +T L A E+ + L++ GA+ + +PL LA + NI+ +
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
LL+ GA+++ + L + G + M ++ + + T L A
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN--TALTLA 1259
Query: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ---DISDTRLLNE 477
C QG V+ LL ++ ++K +PL AAS G + LL D++ + +
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDT 536
D T L +AA GH K +LL+ +GA + + + G T L A+ GG+ +++++
Sbjct: 1320 RD----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLL 568
D D T L A R+GH K V L+
Sbjct: 1376 GAD-VDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 86.7 bits (213), Expect = 1e-16
Identities = 77/301 (25%), Positives = 140/301 (46%), Gaps = 21/301 (6%)
Query: 70 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129
AA G + ++E I D+ ++ + + +TPL A + E V+ LL+RGAN RN
Sbjct: 1123 AATAGHVGVVE-ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181
Query: 130 NMMAPLHIAVQGMNNEVMKVLLE-HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188
+ PL +A G ++K+LL I+ + G + +++A ++ A+++LL G
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
Query: 189 A---KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
+ ++N+ + A F G E + ++L R+ ++ TPL
Sbjct: 1242 SDINAQIETNRNTALTL--ACFQGRTEVVSLLL--------DRKANVEHRAKTGLTPLME 1291
Query: 246 AVQNGDLEMIKMCLDNGAQID--PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVN 303
A G E+ ++ LD GA ++ PV R TA+ AA +G + +L+I +D+ N
Sbjct: 1292 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRN 1350
Query: 304 TTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLS 363
T L A+ H ++ L+ GAD++ D+ +PL+ A +V L+
Sbjct: 1351 KKG---NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Query: 364 K 364
+
Sbjct: 1408 E 1408
Score = 71.6 bits (174), Expect = 4e-12
Identities = 81/345 (23%), Positives = 145/345 (42%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A GD+ ++ L G ++ + + + A + G E+ +++++ ++ D
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L A+ H ++ L++ AD+N S G + L A A ++V +LL G
Sbjct: 301 D---ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 358 ASIE--------------------------------------DHNENGHTPLMEAGSAGH 379
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G + + LL+ +D + ++H T
Sbjct: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH--T 436
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL-EE 495
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL A+I ++ L L
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 160 bits (406), Expect = 5e-39
Identities = 157/563 (27%), Positives = 250/563 (44%), Gaps = 32/563 (5%)
Query: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
G+ G + D P+ S+ + +A L + + D L A
Sbjct: 185 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-RAESTANAGQSDNRSLAEAC 242
Query: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNM 131
+EG + + K+ + ++E + G + L A E + LL+ AN R
Sbjct: 243 SEGDVNAVRKLLIEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 132 -MAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
+ PL A G + +++K+LL H+ DVN + GNTA+ AC + +++LL+ GA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
Query: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
N+ G P+ +A +G E ++L E+G H N K + L LA G
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLL----ENGAGINTH---SNEFKESALTLACYKG 412
Query: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
LEM++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 468
Query: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
+ L A+ H ELA LI GA + +++ EG +PL+ A +V LLL +GA ++
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 529 QTEETQE-TALTLACCGGFLEVADFLIKAGADIEL-------GCSTPLMEAAQEGHLELV 580
Query: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 637
Query: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
A+ GH VQ L+ KGA + +N T L A GG+ ++++L T RL +D
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL-KD 696
Query: 548 GNTALHFAAREGHAKAVALLLSH 570
G+T L AA+ GH V LL +
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDY 719
Score = 121 bits (304), Expect = 3e-27
Identities = 127/454 (27%), Positives = 212/454 (46%), Gaps = 34/454 (7%)
Query: 140 QGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK-PCKSNKWG 198
+G N V K+L+E R+ VN E G + + +AC+ E Q+LL A + K
Sbjct: 244 EGDVNAVRKLLIEGRS--VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 199 CFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMC 258
P+ AA G + ++++L + + +N ++ T L A G ++++K+
Sbjct: 302 ITPLMAAANGGHVKIVKLLL--------AHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 259 LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT-TDGCHETMLHRAS 317
L++GA I+ + T + A + G E+ +L++ + +G +NT ++ E+ L A
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAG----INTHSNEFKESALTLAC 409
Query: 318 LFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIK-DNFGR 376
H E+ +L+ GAD E + L+ A + LLL GAQV++ D+F
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 377 NFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFN 436
LT+ G L ++ E V DE G TPL A R+G V LLG
Sbjct: 470 P---LTLAACGGHVELAALLIERGASLEEVNDE---GYTPLMEAAREGHEEMVALLLGQG 523
Query: 437 VSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
+I++++++ +++ L A G + L++ +D +L TPL AA+ GH
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADI------ELGCSTPLMEAAQEGHL 577
Query: 496 KVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHF 554
++V+ LL GA + + G TAL +A G+T V+L + E G T L
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL-EHESEGGRTPLMK 636
Query: 555 AAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
AAR GH V L+S A++ N+ A+ H L
Sbjct: 637 AARAGHVCTVQFLISKGANV--NRTTANNDHTVL 668
Score = 105 bits (262), Expect = 2e-22
Identities = 142/571 (24%), Positives = 224/571 (39%), Gaps = 55/571 (9%)
Query: 70 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129
AA EG +EL++ + + +H G+T L A E + LL GA+ +
Sbjct: 571 AAQEGHLELVKYLLAAGAN--VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 628
Query: 130 NMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGA 189
PL A + + ++ L+ N +T + +AC + +++LL GA
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Query: 190 KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEE----------------HGYSRQLHIN 233
P K G + +AA G + +L + H +R +
Sbjct: 689 DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVP 748
Query: 234 FMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVK---- 289
+A P+ + Q D + + V GR +A+ T +
Sbjct: 749 V----QALPMVVPPQEPDKPPANVATTLPIRNKAVS-GRASAMSNTPTHSIAASISQPQT 803
Query: 290 ----------LMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKID 339
M+ Y ++DI T+ H+T L A H EL L+ GA I D
Sbjct: 804 PTPSPIISPSAMLPIYP-AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRD 862
Query: 340 SEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFM 397
+G +PLILA + +V +LL GA ++ + T P L R E +
Sbjct: 863 KKGFTPLILAATAGHVGVVEILLDNGADIEAQS-------ERTKDTPLSLACSGGRQEVV 915
Query: 398 QMQQIKELVMDEDN-DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAA 454
++ + + N TPL A G + LL I+S++ K SPL AA
Sbjct: 916 ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 975
Query: 455 SYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHN 513
G + LL SD E + + T L LA G +VV LLL +K +
Sbjct: 976 MNGHTAAVKLLLDMGSDINAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKT 1033
Query: 514 GWTALHHASMGGYTQTMKVILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
G T L A+ GGY + +V+LD + +TAL AA +GH K LL+ A
Sbjct: 1034 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
Query: 573 DI-VLNKQQASFLHLALHNKRKEVVLTIIRS 602
I V NK+ + L LA + +VV ++++
Sbjct: 1094 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
Score = 101 bits (251), Expect = 5e-21
Identities = 98/367 (26%), Positives = 167/367 (45%), Gaps = 35/367 (9%)
Query: 156 IDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
ID++ + E N +TA+ +AC + E +Q LL++GA +K G P+ AA +G +
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
Query: 215 EIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCT 274
EI+L G + + K TPL LA G E++++ L GA + T
Sbjct: 882 EILLDNGADIEAQSE-------RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT 934
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+ AA+ G I+K+++++ + + G ML A++ H L+ +G+D
Sbjct: 935 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML--AAMNGHTAAVKLLLDMGSD 992
Query: 335 IN-KIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
IN +I++ + L LA +V+LLL + A V+ + G L Y
Sbjct: 993 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA----- 1047
Query: 394 PEFMQMQQIKELVMDEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSK 444
++ +++D+ D P L A +G L+G I ++K
Sbjct: 1048 -------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
Query: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504
+PL AA+ G ++ Q L+Q +D ++ D +TPL A + GH KVV+ L+K+
Sbjct: 1101 KGNTPLWLAANGGHLDVVQLLVQAGAD---VDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Query: 505 GALFLSD 511
F SD
Sbjct: 1158 VNQFPSD 1164
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/322 (26%), Positives = 144/322 (44%), Gaps = 44/322 (13%)
Query: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
++++ + + +T L A E V+ LL RGA+ R+ PL +A + V
Sbjct: 821 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 880
Query: 147 MKVLLEHRTIDVNLEGENG-NTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
+++LL++ D+ + E +T + +AC+ E +++LL +GA N P+ A
Sbjct: 881 VEILLDNGA-DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 939
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA--TPLHLAVQNGDLEMIKMCLDNGA 263
A G ++I+L G E IN K +PL LA NG +K+ LD G+
Sbjct: 940 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 991
Query: 264 QIDP-VEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDGCH----- 309
I+ +E R TA+ A QG TE+V L++ + +G ++ G +
Sbjct: 992 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
Query: 310 ------------------ETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
+T L A+ H++ + LI GA I+ + +G +PL LA
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
Query: 352 SASWNIVNLLLSKGAQVDIKDN 373
++V LL+ GA VD DN
Sbjct: 1112 GGHLDVVQLLVQAGADVDAADN 1133
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/332 (26%), Positives = 151/332 (45%), Gaps = 14/332 (4%)
Query: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
T L LA G E+++ L+ GA I+ +K T + AAT G +V++++ + D
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN---GAD 890
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 360
I ++ +T L A E+ + L++ GA+ + +PL LA + NI+ +
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
LL+ GA+++ + L + G + M ++ + + T L A
Sbjct: 951 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN--TALTLA 1008
Query: 421 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ---DISDTRLLNE 477
C QG V+ LL ++ ++K +PL AAS G + LL D++ + +
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDT 536
D T L +AA GH K +LL+ +GA + + + G T L A+ GG+ +++++
Sbjct: 1069 RD----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLL 568
D D T L A R+GH K V L+
Sbjct: 1125 GAD-VDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 86.7 bits (213), Expect = 1e-16
Identities = 77/301 (25%), Positives = 140/301 (46%), Gaps = 21/301 (6%)
Query: 70 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129
AA G + ++E I D+ ++ + + +TPL A + E V+ LL+RGAN RN
Sbjct: 872 AATAGHVGVVE-ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
Query: 130 NMMAPLHIAVQGMNNEVMKVLLE-HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188
+ PL +A G ++K+LL I+ + G + +++A ++ A+++LL G
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
Query: 189 A---KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
+ ++N+ + A F G E + ++L R+ ++ TPL
Sbjct: 991 SDINAQIETNRNTALTL--ACFQGRTEVVSLLL--------DRKANVEHRAKTGLTPLME 1040
Query: 246 AVQNGDLEMIKMCLDNGAQID--PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVN 303
A G E+ ++ LD GA ++ PV R TA+ AA +G + +L+I +D+ N
Sbjct: 1041 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRN 1099
Query: 304 TTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLS 363
T L A+ H ++ L+ GAD++ D+ +PL+ A +V L+
Sbjct: 1100 KKG---NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Query: 364 K 364
+
Sbjct: 1157 E 1157
Score = 71.6 bits (174), Expect = 4e-12
Identities = 81/345 (23%), Positives = 145/345 (42%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A GD+ ++ L G ++ + + + A + G E+ +++++ ++ D
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L A+ H ++ L++ AD+N S G + L A A ++V +LL G
Sbjct: 301 D---ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 358 ASIE--------------------------------------DHNENGHTPLMEAGSAGH 379
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G + + LL+ +D + ++H T
Sbjct: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH--T 436
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL-EE 495
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL A+I ++ L L
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 154 bits (390), Expect = 3e-37
Identities = 138/548 (25%), Positives = 251/548 (45%), Gaps = 45/548 (8%)
Query: 56 LKRCDDMDTFFLHYAAAEGQIELMEK-ITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114
+ +CD L AA G ++++ ++R + LE+ D +G+TPL A + + V
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEI---EDAHGHTPLTLAARQGHTKVV 594
Query: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174
L+ GAN N + + L A G + EV+ LL + + V+ + TA+ A
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAW 653
Query: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234
+ + + LL+ GA+ K++ G + AA+ G +E +E +L G E + ++
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHE---DVDG 710
Query: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
L + G ++ + +D GA++D +K T + AA +G ++V L++
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE- 769
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354
G D V+ TD T L A+ H + + L+ GA ++ IDSEGR+ L +A+A +
Sbjct: 770 --GGAD-VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN 826
Query: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL----------------KNLRPEFMQ 398
+V LL +G + +D+ G LH+ + + L + R F+
Sbjct: 827 VEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFIL 886
Query: 399 MQQ------IKELVMDEDN------DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 446
Q ++ L+ ++ N DG L A +G V L ++ K D
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Query: 447 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 506
+ L+ A ++ + L++ ++ + D G T LH++ GH ++VQ+L+ A
Sbjct: 947 RPTLYILALENQLTMAEYFLENGAN---VEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
Query: 507 -LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA 565
+ +D+ +AL A+ G+ + ++++++ D G TAL AA+EGH V
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA-VVDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 566 LLLSHNAD 573
+LL H AD
Sbjct: 1063 VLLEHGAD 1070
Score = 142 bits (359), Expect = 1e-33
Identities = 126/464 (27%), Positives = 210/464 (45%), Gaps = 53/464 (11%)
Query: 145 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ 204
EV+++L++ ++ E+ T+ I+ ++++ LL GA + + G +
Sbjct: 495 EVLQLLVK---AGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLAN 551
Query: 205 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ 264
AA+SGS + + +++ SR + + TPL LA + G +++ + GA
Sbjct: 552 AAYSGSLDVVNLLV--------SRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 265 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL 324
I+ ++ TA+ AA G TE+V ++ Y+G V+ D T L A+ H ++
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALL--YAGVK--VDCADADSRTALRAAAWGGHEDI 659
Query: 325 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ 384
L+ GA++NK D+EGR+ LI A IV LL GA+V+ +D GR L +
Sbjct: 660 VLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAAL 719
Query: 385 QPYGLKN--------------------------LRPEFMQMQQIKELVMD-------EDN 411
K L + + +L+++ DN
Sbjct: 720 CVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDN 779
Query: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
+G TPL A G VN LL + ++ S + ++ L A++ G + + LL D
Sbjct: 780 NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGYTQTM 530
N D G TPLH+AA GH + + L+++GA D++G AS G+ +
Sbjct: 840 E---NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896
Query: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI 574
+++L+ N D+ DG AL AA EGH V LL SH AD+
Sbjct: 897 QILLE-NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Score = 100 bits (248), Expect = 1e-20
Identities = 100/338 (29%), Positives = 154/338 (45%), Gaps = 26/338 (7%)
Query: 243 LHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIV 302
LHL N LE ++ L PV T I E+++L++ + + V
Sbjct: 457 LHLINSNLQLETAELALWMIWNGTPVRDSLSTLI-----PKEQEVLQLLVKAGAH----V 507
Query: 303 NTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 362
N+ D ++ +A + + L+ GA +N+ DS GR+ L A S S ++VNLL+
Sbjct: 508 NSEDDRTSCIVRQA--LEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLV 565
Query: 363 SKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACR 422
S+GA ++I+D G L L +Q + + + D DG T L A
Sbjct: 566 SRGADLEIEDAHGHTPLTLAARQGH-----TKVVNCLIGCGANINHTDQDGWTALRSAAW 620
Query: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHG 482
G V+ LL V + D ++ L AA G + LLQ ++ +N+ D G
Sbjct: 621 GGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE---VNKADNEG 677
Query: 483 MTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASM-----GGYTQTMKVILDT 536
T L AA GH ++V+ LL GA + D +G TAL A++ G+ + +++D
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI 574
+ D D+DG T L AA EGH V LLL AD+
Sbjct: 738 GAE-VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 137 bits (346), Expect = 4e-32
Identities = 146/559 (26%), Positives = 250/559 (44%), Gaps = 64/559 (11%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH+AA G+ +++E + + + +H DD G PLH A E V LL +GA+PN
Sbjct: 220 LHFAAGFGRKDVVEHLLQMGAN--VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
R+ PLH A +V VLL+H D N+ +G +A+ +A
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGA-DPNIRNTDGKSALDLA-------------D 323
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
AK + ++ + +AA SG++E + +L ++ + + K+TPLHLA
Sbjct: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-------PLNVNCHASDGRKSTPLHLA 376
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+ ++++ L +GA + +KG +H A + G E+ +L++ + VN D
Sbjct: 377 AGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA----CVNAMD 432
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV------NL 360
T LH A+ + E+ L+S GAD ++ G+S + +A + +
Sbjct: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
Query: 361 LLSKGAQVD---IKDNFGRNFLHLTVQQPY------GLKNLRPEFMQMQQIKELVM---- 407
LL + D +K ++ Q + + +L P + +Q+ EL++
Sbjct: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHP---KRKQVTELLLRKGA 549
Query: 408 ---DEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQR 464
+++ D TPLH A + + L +++ ++ LH AA G + TC+
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 465 LLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMG 524
LL SD +++ L G T AA+ G++ V Q+L + + SD + L AS
Sbjct: 610 LLSYGSDPSIIS---LQGFT----AAQMGNEAVQQILSESTPIRTSDVD--YRLLEASKA 660
Query: 525 GYTQTMKVILDT-NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQAS 582
G +T+K + + N+ C D L+ +T LHFAA V LL H AD+ +K
Sbjct: 661 GDLETVKQLCSSQNVNCRD-LEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719
Query: 583 FLHLALHNKRKEVVLTIIR 601
LH A EV ++R
Sbjct: 720 PLHNACSYGHYEVAELLVR 738
Score = 136 bits (343), Expect = 1e-31
Identities = 131/487 (26%), Positives = 216/487 (44%), Gaps = 49/487 (10%)
Query: 79 MEKITRDSSLEVLH-EMDDYGNTPLHCAVEK---NQIESVKFLLSRGANPNLRNFNMMAP 134
+ K+ + +LE+++ + T LHCAV + + + LL +GAN N +N + M P
Sbjct: 502 LAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
Query: 135 LHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKS 194
LH+A + +N+VM+VL +H +N G TA+ A + + ++LL G+ P
Sbjct: 562 LHVAAERAHNDVMEVLHKHGA-KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSII 620
Query: 195 NKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEM 254
+ G AA G++ +I+ E R +++ L A + GDLE
Sbjct: 621 SLQG----FTAAQMGNEAVQQIL----SESTPIRTSDVDYR-------LLEASKAGDLET 665
Query: 255 IK-MCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
+K +C +E T +HFAA +V+ ++ + V+ D L
Sbjct: 666 VKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD----VHAKDKGGLVPL 721
Query: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
H A + H+E+A+ L+ GA +N D +PL A A + I LLL GA K+
Sbjct: 722 HNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNR 781
Query: 374 FGRNFLHLTVQQPYGLKN-LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNL 432
G L L + +++ LR + + K+ + CTP + CR +
Sbjct: 782 DGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR--------DT 833
Query: 433 LGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKN 492
G N +PLH AA Y + + LL+ +D +N D G+ PLH AA
Sbjct: 834 QGRN----------STPLHLAAGYNNLEVAEYLLEHGAD---VNAQDKGGLIPLHNAASY 880
Query: 493 GHDKVVQLLLK-KGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTA 551
GH + LL+K + +D +T LH A+ G TQ ++L T + +++G T
Sbjct: 881 GHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK-NQEGQTP 939
Query: 552 LHFAARE 558
L A +
Sbjct: 940 LDLATAD 946
Score = 126 bits (316), Expect = 1e-28
Identities = 151/600 (25%), Positives = 244/600 (40%), Gaps = 95/600 (15%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + G E+ E + + + ++ MD + TPLH A KN++E LLS GA+P L
Sbjct: 406 LHNACSYGHYEVTELLLKHGAC--VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
Query: 127 RNFNM-----MAPL-------------HIAVQGMNN----EVMKVL-LEHRTIDVNLEGE 163
N + MAP H +Q +V K L LE E
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
Query: 164 NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEE 223
+ + + ++LL+KGA + NK P+H AA + ME++ + G +
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 224 HGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHF----- 278
+N ++ T LH A G L+ ++ L G+ + TA
Sbjct: 584 --------MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAV 635
Query: 279 ---------------------AATQGATEIVKLMISSYSGSVDIVNTTD--GCHETMLHR 315
A+ G E VK + SS + VN D G H T LH
Sbjct: 636 QQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQN-----VNCRDLEGRHSTPLHF 690
Query: 316 ASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFG 375
A+ ++ + +YL+ GAD++ D G PL A + + + LL+ GA V++ D +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 376 RNFLH-LTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLG 434
LH + Y + L + K + DG TPL + G + +LL
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKK------NRDGNTPLDLV--KEGDTDIQDLLR 802
Query: 435 FNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGM--TPLHLAAKN 492
+ ++ +K C +Q + +N D G TPLHLAA
Sbjct: 803 GDAALLDAAK---------------KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
Query: 493 GHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTA 551
+ +V + LL+ GA + D G LH+A+ G+ +++ N C + D+ T
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT-CVNATDKWAFTP 906
Query: 552 LHFAAREGHAKAVALLLSHNADIVLNKQQASF-LHLALHNKRKEVVLTIIRSKRWDECLK 610
LH AA++G + ALLL+H AD + Q+ L LA + + +++ + + C K
Sbjct: 907 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK 966
Score = 101 bits (252), Expect = 3e-21
Identities = 84/308 (27%), Positives = 145/308 (47%), Gaps = 22/308 (7%)
Query: 58 RCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117
R D+D L A+ G +E ++++ ++ +++ +TPLH A N++ V++L
Sbjct: 646 RTSDVDYRLLE-ASKAGDLETVKQLCSSQNVNC-RDLEGRHSTPLHFAAGYNRVSVVEYL 703
Query: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177
L GA+ + ++ + PLH A + EV ++L+ H VN+ T + A
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA-SVNVADLWKFTPLHEAAAKGK 762
Query: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII--------------LRFGEE 223
E ++LLK GA P K N+ G P+ G + +++ L ++
Sbjct: 763 YEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQK 821
Query: 224 HGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQG 283
++ +TPLHLA +LE+ + L++GA ++ +KG +H AA+ G
Sbjct: 822 LCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYG 881
Query: 284 ATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGR 343
+I L+I + VN TD T LH A+ +L L++ GAD + EG+
Sbjct: 882 HVDIAALLIKYNT----CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQ 937
Query: 344 SPLILATA 351
+PL LATA
Sbjct: 938 TPLDLATA 945
Score = 92.8 bits (229), Expect = 2e-18
Identities = 107/415 (25%), Positives = 160/415 (38%), Gaps = 86/415 (20%)
Query: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294
M K++PLH A G ++++ L GA + + G +H A + G E+V L++
Sbjct: 212 MAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ 271
Query: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASA- 353
+ N D + T LH A++ ++ L+ GAD N +++G+S L LA SA
Sbjct: 272 GADP----NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 354 --------------------SWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
++ LL D LHL G +R
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAA----GYNRVR 383
Query: 394 PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA 453
+ +Q + V +D G PLH AC G LL +++ + +PLH A
Sbjct: 384 IVQLLLQHGAD-VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
Query: 454 ASYGRINTCQRLLQDISDTRLLN---------------------------------EGDL 480
AS R+ C LL +D L+N E DL
Sbjct: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
Query: 481 HGM------------------TPLHLAAKNGHDK---VVQLLLKKGALFLSDHNGW-TAL 518
+ T LH A + H K V +LLL+KGA + + T L
Sbjct: 503 AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
Query: 519 HHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
H A+ + M+V+ K + LD G TALH AA GH + LLLS+ +D
Sbjct: 563 HVAAERAHNDVMEVLHKHGAK-MNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
Score = 87.0 bits (214), Expect = 9e-17
Identities = 87/328 (26%), Positives = 132/328 (40%), Gaps = 59/328 (17%)
Query: 267 PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD--GCHETMLHRASLFDHHEL 324
P G + A G VK ++ + + VN D G + LH A+ F ++
Sbjct: 177 PAVSGALRELLEACRNGDVSRVKRLVDAAN-----VNAKDMAGRKSSPLHFAAGFGRKDV 231
Query: 325 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLH---- 380
++L+ +GA+++ D G PL A + +V+LLL +GA + +DN+ LH
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAI 291
Query: 381 -------LTVQQPYGLKNLR----PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSV 429
+ + Q N+R + + + L A R G +
Sbjct: 292 KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKL 351
Query: 430 NNLL-GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488
LL NV+ H+ K +PLH AA Y R+ Q LLQ +D ++G G+ PLH
Sbjct: 352 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG---GLVPLHN 408
Query: 489 AAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDG 548
A GH +V +LLLK GA C + +D
Sbjct: 409 ACSYGHYEVTELLLKHGA---------------------------------CVNAMDLWQ 435
Query: 549 NTALHFAAREGHAKAVALLLSHNADIVL 576
T LH AA + + +LLLSH AD L
Sbjct: 436 FTPLHEAASKNRVEVCSLLLSHGADPTL 463
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 134 bits (336), Expect = 6e-31
Identities = 109/366 (29%), Positives = 165/366 (45%), Gaps = 52/366 (14%)
Query: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299
A+ LHLAV+ G E K L N A + + T +H A + +V+L+++
Sbjct: 439 ASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS-- 496
Query: 300 DIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVN 359
VN D T LH A+ L+ A +N++D EGR+P+ +A NIV
Sbjct: 497 --VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 360 LLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHY 419
+LL +G V + + D PLHY
Sbjct: 555 ILLRRGVDVSL--------------------------------------QGKDAWLPLHY 576
Query: 420 ACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEG 478
A QG V L VS+++++ D ++PLH AA G + L+ SD +N
Sbjct: 577 AAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD---VNVC 633
Query: 479 DLHGMTPLHLAAKNGHDKVVQLLLKKGA---LFLSDHNGWTALHHASMGGYTQTMKVILD 535
L TPLH+AA+ GH +LLL +GA SD G+TALH A+ G+ T+K++++
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD--GYTALHLAARNGHLATVKLLVE 691
Query: 536 TNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEV 595
R TALH AA GH++ V L+S + + ++Q S LHLA + +
Sbjct: 692 EKADVLAR-GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQT 750
Query: 596 VLTIIR 601
V T++R
Sbjct: 751 VETLLR 756
Score = 112 bits (281), Expect = 2e-24
Identities = 93/370 (25%), Positives = 172/370 (46%), Gaps = 27/370 (7%)
Query: 139 VQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWG 198
V G +++MK+L DV+L ++G + + +A E + LL A P SN+ G
Sbjct: 415 VSGDTSKLMKILQPQ---DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471
Query: 199 CFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMC 258
P+H A + +E++L +R++ +N + + T LH A QNGD ++
Sbjct: 472 STPLHMAVERRVRGVVELLL--------ARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 259 LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETM-LHRAS 317
L+ A ++ V+ T +H A G IV++++ VD+ + G + LH A+
Sbjct: 524 LEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR---GVDV--SLQGKDAWLPLHYAA 578
Query: 318 LFDHHELADYLI-SVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGR 376
H + L G +N +GR+PL LA + + +L+ + V++ +
Sbjct: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ 638
Query: 377 NFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFN 436
LH+ + G + + KE + +DG T LH A R G +V L+
Sbjct: 639 TPLHVAAET--GHTSTARLLLHRGAGKEAM---TSDGYTALHLAARNGHLATVKLLVEEK 693
Query: 437 VSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDK 496
+ ++ ++ LH AA++G +++++ +++ D G++ LHLAA+ H +
Sbjct: 694 ADVLARGPLNQTALHLAAAHGH----SEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQ 749
Query: 497 VVQLLLKKGA 506
V+ LL+ GA
Sbjct: 750 TVETLLRHGA 759
Score = 112 bits (279), Expect = 3e-24
Identities = 104/375 (27%), Positives = 161/375 (42%), Gaps = 36/375 (9%)
Query: 96 DYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRT 155
D G + LH AVE Q E K+LL ANPNL N PLH+AV+ V+++LL R
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLA-RK 494
Query: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
I VN + E+ TA+ A + + ++LL+K A + + G P+H A G + +
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN-GAQIDPVEKGRCT 274
I+LR R + ++ PLH A G L ++K+ G ++ T
Sbjct: 555 ILLR--------RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
+H AA +G + +++I S VN +T LH A+ H A L+ GA
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSD----VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662
Query: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRP 394
+ S+G + L LA + V LL+ + A V + + LHL +
Sbjct: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS------ 716
Query: 395 EFMQMQQIKELVMDE-----DNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSP 449
+ ++ELV + D G + LH A + +V LL I+ +S
Sbjct: 717 -----EVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS------ 765
Query: 450 LHFAASYGRINTCQR 464
L F +G T R
Sbjct: 766 LKFQGGHGPAATLLR 780
Score = 111 bits (278), Expect = 3e-24
Identities = 92/339 (27%), Positives = 153/339 (45%), Gaps = 23/339 (6%)
Query: 198 GCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKM 257
G +H A +G +EC + +L + N N +TPLH+AV+ ++++
Sbjct: 438 GASLLHLAVEAGQEECAKWLLL--------NNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 258 CLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRAS 317
L ++ ++ + TA+HFAA G +L++ + VN D T +H A
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS----VNEVDFEGRTPMHVAC 545
Query: 318 LFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK-GAQVDIKDNFGR 376
+ L+ G D++ + PL A IV LL + G V+ + GR
Sbjct: 546 QHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR 605
Query: 377 NFLHLTVQQP-YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGF 435
LHL Q+ Y + + + + L+ TPLH A G + LL
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ------TPLHVAAETGHTSTARLLLHR 659
Query: 436 NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
+ + D + LH AA G + T + L+++ +D +L G L+ T LHLAA +GH
Sbjct: 660 GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD--VLARGPLN-QTALHLAAAHGHS 716
Query: 496 KVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVIL 534
+VV+ L+ + L D G +ALH A+ G + QT++ +L
Sbjct: 717 EVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
Score = 93.6 bits (231), Expect = 9e-19
Identities = 72/270 (26%), Positives = 127/270 (47%), Gaps = 15/270 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH+AA G E ++ + + V +E+D G TP+H A + Q V+ LL RG + +L
Sbjct: 508 LHFAAQNGD-ESSTRLLLEKNASV-NEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL 565
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + PLH A + ++K+L + + VN + +G T + +A + +IL+
Sbjct: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
+ + P+H AA +G ++L G M + T LHLA
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK--------EAMTSDGYTALHLA 677
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
+NG L +K+ ++ A + TA+H AA G +E+V+ ++S+ D+++ D
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA-----DVIDLFD 732
Query: 307 GCHETMLHRASLFDHHELADYLISVGADIN 336
+ LH A+ H + + L+ GA IN
Sbjct: 733 EQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 40.0 bits (92), Expect = 0.012
Identities = 22/62 (35%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AAA G E++E++ S +V+ D+ G + LH A + ++V+ LL GA+ NL
Sbjct: 707 LHLAAAHGHSEVVEELV---SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Query: 127 RN 128
++
Sbjct: 764 QS 765
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 130 bits (328), Expect = 5e-30
Identities = 120/420 (28%), Positives = 186/420 (44%), Gaps = 25/420 (5%)
Query: 93 EMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLE 152
E ++ G TPL A E+ +E VK L+ GAN NL + + L A + + +++ LL+
Sbjct: 33 ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLK 92
Query: 153 HRTIDVNLEGEN--GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGS 210
VNLE + G TA++ AC ++ +++LL GA P + + +PI AA G
Sbjct: 93 ---CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
Query: 211 KECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEK 270
+ + ++L+ G + +N + TPL A + G LE +K L GA +D
Sbjct: 150 ADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
Query: 271 GRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLIS 330
TA+ A G T+ VK ++ VN TD T L AS H E+ L+
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPN----VNLTDKDGNTALMIASKEGHTEIVQDLLD 257
Query: 331 VGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLK 390
G +N D G + LI A IV LL K A +DI+ + L+ V++ G
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK--GNA 315
Query: 391 NLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
+ + +Q E+ DG TPL A + V LL + + K +PL
Sbjct: 316 TMVRDILQCNPDTEICT---KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
Query: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS 510
H A + LL++ D RLL + G TP ++ + + Q+ GA LS
Sbjct: 373 HIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF---GARHLS 429
Score = 92.8 bits (229), Expect = 2e-18
Identities = 109/436 (25%), Positives = 179/436 (41%), Gaps = 56/436 (12%)
Query: 139 VQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWG 198
V+ N +K LLE + DV+ E G T ++IA N E ++ L+K GA +
Sbjct: 13 VEEENIPALKALLE-KCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN 71
Query: 199 CFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMC 258
+ A+ G +E +L+ G +++ + G T L A G +++++
Sbjct: 72 WTALISASKEGHVHIVEELLKCG--------VNLEHRDMGGWTALMWACYKGRTDVVELL 123
Query: 259 LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASL 318
L +GA I +AA +G +IV L++ + + VN +D T L A+
Sbjct: 124 LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAK----VNCSDKYGTTPLVWAAR 179
Query: 319 FDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNF 378
H E +L+++GAD+++ + + LI+A V +L + V++ D G
Sbjct: 180 KGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA 239
Query: 379 LHLTVQQPYGLKNLRPEFMQ-MQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNV 437
L + ++ + E +Q + V D G T L A R G V LL
Sbjct: 240 LMIASKEGH------TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYA 293
Query: 438 SIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKV 497
I + +D K+ L++A G + +LQ DT + + G TPL A K + +V
Sbjct: 294 DIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD---GETPLIKATKMRNIEV 350
Query: 498 VQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAR 557
V+LLL KGA +D+ G+T LH A R
Sbjct: 351 VELLLDKGAK---------------------------------VSAVDKKGDTPLHIAIR 377
Query: 558 EGHAKAVALLLSHNAD 573
K LLL + D
Sbjct: 378 GRSRKLAELLLRNPKD 393
Score = 91.3 bits (225), Expect = 5e-18
Identities = 77/294 (26%), Positives = 137/294 (46%), Gaps = 48/294 (16%)
Query: 69 YAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRN 128
+AA G +++ + ++ + ++ D YG TPL A K +E VK LL+ GA+ +
Sbjct: 143 WAAGRGHADIVHLLLQNGAK--VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 129 FNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188
N M L +AV+G + +K +L+ R +VNL ++GNTA++IA ++E +Q LL G
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILK-RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259
Query: 189 AKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQ 248
++N + T L AV+
Sbjct: 260 T-----------------------------------------YVNIPDRSGDTVLIGAVR 278
Query: 249 NGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGC 308
G +E+++ L A ID + TA+++A +G +V+ ++ + + T DG
Sbjct: 279 GGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTE--ICTKDG- 335
Query: 309 HETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 362
ET L +A+ + E+ + L+ GA ++ +D +G +PL +A S + LLL
Sbjct: 336 -ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
Score = 80.5 bits (197), Expect = 8e-15
Identities = 89/336 (26%), Positives = 146/336 (43%), Gaps = 51/336 (15%)
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRC--TAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
V+ ++ +K L+ +D E+ C T + AA QG EIVK +I + + N
Sbjct: 13 VEEENIPALKALLEKCKDVD--ERNECGQTPLMIAAEQGNLEIVKELIKNGANC----NL 66
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
D + T L AS H + + L+ G ++ D G + L+ A ++V LLLS
Sbjct: 67 EDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH 126
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424
GA + GL ++ P + +A +G
Sbjct: 127 GANPSVT----------------GLYSVYP----------------------IIWAAGRG 148
Query: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
V+ LL ++ K +PL +AA G + + LL +D +++ + MT
Sbjct: 149 HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD---VDQEGANSMT 205
Query: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDR 543
L +A K G+ + V+ +LK+ + L+D +G TAL AS G+T+ ++ +LD +
Sbjct: 206 ALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY-VNI 264
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQ 579
D G+T L A R GH + V LL ADI + Q
Sbjct: 265 PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ 300
Score = 57.4 bits (137), Expect = 7e-08
Identities = 44/153 (28%), Positives = 80/153 (52%), Gaps = 3/153 (1%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L A+ EG E+++ + + ++ D G+T L AV +E V+ LL + A+ ++
Sbjct: 240 LMIASKEGHTEIVQDLLDAGTY--VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDI 297
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
R + L+ AV+ N +++ +L+ D + ++G T +I A N E +++LL
Sbjct: 298 RGQDNKTALYWAVEKGNATMVRDILQCNP-DTEICTKDGETPLIKATKMRNIEVVELLLD 356
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILR 219
KGAK +K G P+H A S++ E++LR
Sbjct: 357 KGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/131 (26%), Positives = 61/131 (46%), Gaps = 4/131 (3%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L++A +G ++ I + + + D G TPL A + IE V+ LL +GA +
Sbjct: 306 LYWAVEKGNATMVRDILQCNPDTEICTKD--GETPLIKATKMRNIEVVELLLDKGAKVSA 363
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGEN--GNTAVIIACTTNNSEALQIL 184
+ PLHIA++G + ++ ++LL + L N G T I C+ S QI
Sbjct: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423
Query: 185 LKKGAKPCKSN 195
+ P +++
Sbjct: 424 GARHLSPTETD 434
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 129 bits (323), Expect = 2e-29
Identities = 135/528 (25%), Positives = 234/528 (44%), Gaps = 57/528 (10%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH+AA G+ +++E + ++ + + DD G PLH A E V LL GA+PN
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGAN--VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
R+ PLH A +V VLL+H + + +G TA+ +A
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRTALDLA-------------D 165
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
AK + ++ + ++A SG++E M +L ++ + + K+TPLHLA
Sbjct: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLT-------PLNVNCHASDGRKSTPLHLA 218
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
++++++ L +GA + +KG +H A + G E+ +L++ + VN D
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA----CVNAMD 274
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILA-TASASWNIV-----NL 360
T LH A+ + E+ L+S GAD ++ +S + LA T + +
Sbjct: 275 LWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
Query: 361 LLSKGAQVD---IKDNFGR---NFLHLTVQQPYGLKNLRPEFMQMQQIKELVM------- 407
LL + D IK + NF H + + + +QI EL++
Sbjct: 335 LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANIN 394
Query: 408 DEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467
++ + TPLH A + V ++ +++ ++ LH AA G + TC+ LL
Sbjct: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
Query: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYT 527
D +++ L G T L + +N VQ LL++G + L + L A+ G
Sbjct: 455 YGCDPNIIS---LQGFTALQMGNEN-----VQQLLQEG-ISLGNSEADRQLLEAAKAGDV 505
Query: 528 QTMKVILDT-NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI 574
+T+K + ++ C D ++ +T LHFAA V LL H AD+
Sbjct: 506 ETVKKLCTVQSVNCRD-IEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Score = 127 bits (318), Expect = 8e-29
Identities = 142/576 (24%), Positives = 242/576 (42%), Gaps = 94/576 (16%)
Query: 60 DDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLS 119
D D LH A + G E+ E + + + ++ MD + TPLH A KN++E LLS
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGAC--VNAMDLWQFTPLHEAASKNRVEVCSLLLS 298
Query: 120 RGANPNLRNFNMMAPLHIA------------------VQGMNNEVMKVLLEHRTID-VNL 160
GA+P L N + + + +A +Q + + +H +++ VN
Sbjct: 299 YGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNF 358
Query: 161 EG-ENGNTAVIIACTT---NNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEI 216
+ + TA+ A + + ++LL+KGA + K P+H A+ + +E+
Sbjct: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
Query: 217 ILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276
+++ + +N ++N T LH A G L+ ++ L G + + TA+
Sbjct: 419 VVK--------HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
Query: 277 HF--------------------------AATQGATEIVKLMISSYSGSVDIVNTTD--GC 308
AA G E VK + + V VN D G
Sbjct: 471 QMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCT-----VQSVNCRDIEGR 525
Query: 309 HETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQV 368
T LH A+ ++ + +YL+ GAD++ D G PL A + + + LL+ GA V
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585
Query: 369 DIKDNFGRNFLH-LTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPG 427
++ D + LH + Y + L + Q ++ DG TPL + G
Sbjct: 586 NVADLWKFTPLHEAAAKGKYEICKL------LLQHGADPTKKNRDGNTPLDLV--KDGDT 637
Query: 428 SVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGM--TP 485
+ +LL + ++ +K C ++ +S +N D G TP
Sbjct: 638 DIQDLLRGDAALLDAAK---------------KGCLARVKKLSSPDNVNCRDTQGRHSTP 682
Query: 486 LHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRL 544
LHLAA + +V + LL+ GA + D G LH+A+ G+ +++ N C +
Sbjct: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNAT 741
Query: 545 DEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQ 580
D+ T LH AA++G + ALLL+H AD L Q+
Sbjct: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Score = 119 bits (299), Expect = 1e-26
Identities = 141/537 (26%), Positives = 215/537 (40%), Gaps = 61/537 (11%)
Query: 92 HEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLL 151
H D +TPLH A N+++ V+ LL GA+ + ++ + PLH A + EV ++L+
Sbjct: 205 HASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264
Query: 152 EHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSK 211
+H VN T + A + N E +LL GA P N I A K
Sbjct: 265 KHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK 323
Query: 212 ECM------EIILRFGEEHGYSR---QLHINFMN----NGKATPLHLAVQNGDLEMIKMC 258
E + +L+ E +R L + +N T LH A + + ++C
Sbjct: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQIC 383
Query: 259 ---LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHR 315
L GA I+ K T +H A+ + ++V++++ + VN D +T LHR
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK----VNALDNLGQTSLHR 439
Query: 316 ASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFG 375
A+ H + L+S G D N I +G + L + + V LL +G +
Sbjct: 440 AAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLG-NSEAD 493
Query: 376 RNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGF 435
R L G + +Q + D + TPLH+A V LL
Sbjct: 494 RQLLEAA---KAGDVETVKKLCTVQSVN--CRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
Query: 436 NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
+H+K K PLH A SYG + L + ++N DL TPLH AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELL---VKHGAVVNVADLWKFTPLHEAAAKGKY 605
Query: 496 KVVQLLLKKGA-LFLSDHNGWT---------------------ALHHASMGGYTQTMKVI 533
++ +LLL+ GA + +G T L A G + K+
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLS 665
Query: 534 LDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHN 590
N+ C D +T LH AA + + LL H AD+ N Q L + LHN
Sbjct: 666 SPDNVNCRDTQGRH-STPLHLAAGYNNLEVAEYLLQHGADV--NAQDKGGL-IPLHN 718
Score = 112 bits (281), Expect = 2e-24
Identities = 121/477 (25%), Positives = 200/477 (41%), Gaps = 69/477 (14%)
Query: 81 KITRDSSLEVLH-EMDDYGNTPLHCAVEK---NQIESVKFLLSRGANPNLRNFNMMAPLH 136
+I + SLE+++ + T LHCA + + + LL +GAN N + + PLH
Sbjct: 346 RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH 405
Query: 137 IAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNK 196
+A + +N+V++V+++H VN G T++ A + + ++LL G P +
Sbjct: 406 VASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL 464
Query: 197 WGCFPIHQAAFSGSKECMEIILRFGEEHGYS---RQL---------------------HI 232
G A E ++ +L+ G G S RQL +
Sbjct: 465 QGF-----TALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNC 519
Query: 233 NFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMI 292
+ ++TPLH A + +++ L +GA + +KG +H A + G E+ +L++
Sbjct: 520 RDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 579
Query: 293 SSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATAS 352
+ +VN D T LH A+ +E+ L+ GAD K + +G +PL L
Sbjct: 580 KHGA----VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK-D 634
Query: 353 ASWNIVNLL--------------------LSKGAQVDIKDNFGRNF--LHLTVQQPYGLK 390
+I +LL LS V+ +D GR+ LHL G
Sbjct: 635 GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAA----GYN 690
Query: 391 NLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
NL +Q + V +D G PLH A G L+ +N +++ K +PL
Sbjct: 691 NLEVAEYLLQHGAD-VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPL 749
Query: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL 507
H AA GR C LL +D L N+ G TPL L + + ++ + AL
Sbjct: 750 HEAAQKGRTQLCALLLAHGADPTLKNQ---EGQTPLDLVSADDVSALLTAAMPPSAL 803
Score = 102 bits (254), Expect = 2e-21
Identities = 101/358 (28%), Positives = 150/358 (41%), Gaps = 61/358 (17%)
Query: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGR-CTAIHFAATQGATEIVKLMISSYSGS 298
A L A +NGD+E +K + GR T +HFAA G ++V+ ++ + +
Sbjct: 25 ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN- 83
Query: 299 VDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV 358
V D LH A F H E+ + L+ GAD N D+ +PL A ++
Sbjct: 84 ---VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVC 140
Query: 359 NLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLH 418
+LL GA+ I++ GR L L P L E+ + + ++
Sbjct: 141 IVLLQHGAEPTIRNTDGRTALDLA--DPSAKAVLTGEYKKDELLE--------------- 183
Query: 419 YACRQGGPGSVNNLLG-FNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
+ R G + LL NV+ H+ K +PLH AA Y R+ Q LLQ +D ++
Sbjct: 184 -SARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTN 537
GDL PLH A GH +V +LL+K GA
Sbjct: 243 GDL---VPLHNACSYGHYEVTELLVKHGA------------------------------- 268
Query: 538 LKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHNKRKE 594
C + +D T LH AA + + +LLLS+ AD +LN S + LA + KE
Sbjct: 269 --CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE 324
Score = 39.7 bits (91), Expect = 0.016
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 2/71 (2%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA+ G +++ + + ++ ++ D + TPLH A +K + + LL+ GA+P L
Sbjct: 716 LHNAASYGHVDVAALLIKYNAC--VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
Query: 127 RNFNMMAPLHI 137
+N PL +
Sbjct: 774 KNQEGQTPLDL 784
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 123 bits (309), Expect = 9e-28
Identities = 140/544 (25%), Positives = 242/544 (44%), Gaps = 35/544 (6%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
+H AA G ++++ +S + + D +G TPL V ++++ LL GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + LH+A Q N MK+LL R + + E T + + + + L +LLK
Sbjct: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE-MTPLHLTTRHRSPKCLALLLK 135
Query: 187 KGA--KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
A + +K +H +A+ + E ++++++ G GK PLH
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-------EGK-IPLH 187
Query: 245 LAVQNGDLEMIK--MCLDNGAQIDPV-----EKGRCTAIHFAATQGATEIVKLMISSYSG 297
A + D + C+ + A + + +GR T +HFA G +V ++ S S
Sbjct: 188 WAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR-TPLHFAVADGNVTVVDVLTSYESC 246
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVG-ADINKIDSEGRSPLILATASASWN 356
+ + + D T LH A+L H ++ L+ + DS+G +PL A S
Sbjct: 247 N---ITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303
Query: 357 IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTP 416
V + L + D D GR + G ++ + ++ ++ M D G T
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGK--GSDDVLRTMLSLKSDIDINM-ADKYGGTA 360
Query: 417 LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476
LH A G +V LL N + + K +PL A G + Q L++ + L+
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV- 419
Query: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLK-KGALFLSDHNGWTALHHASMGGYTQTMKVILD 535
D G + LH AA G+ V Q+L++ K + D+ G T L A+ GGY M V+++
Sbjct: 420 --DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 536 TNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA---DIVLNKQQASFLHLALHNKR 592
N + D++G TALH++ G+ A+ LLL A + N+++ + L AL +R
Sbjct: 478 NNAD-PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536
Query: 593 KEVV 596
EV+
Sbjct: 537 HEVI 540
Score = 112 bits (281), Expect = 2e-24
Identities = 125/521 (23%), Positives = 232/521 (44%), Gaps = 70/521 (13%)
Query: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177
+++ N ++ + +H A + ++ L+ + + E + G T ++ +
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237
+ LLK GA K++ +H AA G+ M+++L +R+ + +
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLL--------TRRANWMQKDL 112
Query: 238 GKATPLHLAVQNGDLEMIKMCLDNGA--QIDPVEKGRCTAIHFAATQGATEIVKLMISSY 295
+ TPLHL ++ + + + L A ++D +K + TA+H++A E VKL+I
Sbjct: 113 EEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHD 172
Query: 296 SGSVDIVNTTDGCHETMLHRASLFDH------HELADYLISVGAD--INKIDSEGRSPLI 347
S + D + LH A+ +H H + L + + +N D EGR+PL
Sbjct: 173 SN----IGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
Query: 348 LATASASWNIVNLLLS-KGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELV 406
A A + +V++L S + + DN R LH L + + + +++ K
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL----LGHAQIVHLLLERNKSGT 282
Query: 407 MDEDNDGCTPLHYACRQ------------------------------GGPGSVNNL---- 432
+ D+ G TPLHYA + G GS + L
Sbjct: 283 IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML 342
Query: 433 -LGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAK 491
L ++ I+ K + LH AA G ++T + LL++ + ++ D+ TPL A +
Sbjct: 343 SLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQ---VDATDVMKHTPLFRACE 399
Query: 492 NGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNT 550
GH V+Q L+K GA + L D +G + LH A++GG +++++ + + D G T
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN-PNVQDYAGRT 458
Query: 551 ALHFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHN 590
L AA G+ +A+L+ +NAD + +K+ + LH + +N
Sbjct: 459 PLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Score = 96.7 bits (239), Expect = 1e-19
Identities = 103/424 (24%), Positives = 181/424 (42%), Gaps = 25/424 (5%)
Query: 95 DDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVM---KVLL 151
D T LH + N E VK L+ +N + + PLH A + + + +L
Sbjct: 146 DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205
Query: 152 EHRTID--VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCF---PIHQAA 206
+ + +N + G T + A N + +L + C + P+H AA
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHWAA 263
Query: 207 FSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQID 266
G + + ++L E S + + ATPLH A Q+ E +K+ L + + D
Sbjct: 264 LLGHAQIVHLLL----ERNKSGTIPSDSQG---ATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 267 PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELAD 326
+ T+ +AA +G+ ++++ M+S S +DI N D T LH A+L H
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKS-DIDI-NMADKYGGTALHAAALSGHVSTVK 374
Query: 327 YLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQP 386
L+ A ++ D +PL A +++ L+ GA+VD+ D G + LH
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA--- 431
Query: 387 YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 446
G + + +I V +D G TPL A G + L+ N + + K+
Sbjct: 432 LGGNADVCQILIENKINPNV--QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
Query: 447 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 506
++ LH++ + G ++ +LL D + E + TPL A +V+Q +L+ GA
Sbjct: 490 RTALHWSCNNGYLDAI-KLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Query: 507 LFLS 510
L ++
Sbjct: 549 LSIA 552
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 123 bits (309), Expect = 9e-28
Identities = 140/544 (25%), Positives = 242/544 (44%), Gaps = 35/544 (6%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
+H AA G ++++ +S + + D +G TPL V ++++ LL GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNK 76
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ + LH+A Q N MK+LL R + + E T + + + + L +LLK
Sbjct: 77 TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEE-MTPLHLTTRHRSPKCLALLLK 135
Query: 187 KGA--KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
A + +K +H +A+ + E ++++++ G GK PLH
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-------EGK-IPLH 187
Query: 245 LAVQNGDLEMIK--MCLDNGAQIDPV-----EKGRCTAIHFAATQGATEIVKLMISSYSG 297
A + D + C+ + A + + +GR T +HFA G +V ++ S S
Sbjct: 188 WAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR-TPLHFAVADGNVTVVDVLTSYESC 246
Query: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVG-ADINKIDSEGRSPLILATASASWN 356
+ + + D T LH A+L H ++ L+ + DS+G +PL A S
Sbjct: 247 N---ITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303
Query: 357 IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTP 416
V + L + D D GR + G ++ + ++ ++ M D G T
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGK--GSDDVLRTMLSLKSDIDINM-ADKYGGTA 360
Query: 417 LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476
LH A G +V LL N + + K +PL A G + Q L++ + L+
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV- 419
Query: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLK-KGALFLSDHNGWTALHHASMGGYTQTMKVILD 535
D G + LH AA G+ V Q+L++ K + D+ G T L A+ GGY M V+++
Sbjct: 420 --DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 536 TNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA---DIVLNKQQASFLHLALHNKR 592
N + D++G TALH++ G+ A+ LLL A + N+++ + L AL +R
Sbjct: 478 NNAD-PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536
Query: 593 KEVV 596
EV+
Sbjct: 537 HEVI 540
Score = 112 bits (281), Expect = 2e-24
Identities = 125/521 (23%), Positives = 232/521 (44%), Gaps = 70/521 (13%)
Query: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177
+++ N ++ + +H A + ++ L+ + + E + G T ++ +
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237
+ LLK GA K++ +H AA G+ M+++L +R+ + +
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLL--------TRRANWMQKDL 112
Query: 238 GKATPLHLAVQNGDLEMIKMCLDNGA--QIDPVEKGRCTAIHFAATQGATEIVKLMISSY 295
+ TPLHL ++ + + + L A ++D +K + TA+H++A E VKL+I
Sbjct: 113 EEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHD 172
Query: 296 SGSVDIVNTTDGCHETMLHRASLFDH------HELADYLISVGAD--INKIDSEGRSPLI 347
S + D + LH A+ +H H + L + + +N D EGR+PL
Sbjct: 173 SN----IGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
Query: 348 LATASASWNIVNLLLS-KGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELV 406
A A + +V++L S + + DN R LH L + + + +++ K
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL----LGHAQIVHLLLERNKSGT 282
Query: 407 MDEDNDGCTPLHYACRQ------------------------------GGPGSVNNL---- 432
+ D+ G TPLHYA + G GS + L
Sbjct: 283 IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML 342
Query: 433 -LGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAK 491
L ++ I+ K + LH AA G ++T + LL++ + ++ D+ TPL A +
Sbjct: 343 SLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQ---VDATDVMKHTPLFRACE 399
Query: 492 NGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNT 550
GH V+Q L+K GA + L D +G + LH A++GG +++++ + + D G T
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN-PNVQDYAGRT 458
Query: 551 ALHFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHN 590
L AA G+ +A+L+ +NAD + +K+ + LH + +N
Sbjct: 459 PLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Score = 96.7 bits (239), Expect = 1e-19
Identities = 103/424 (24%), Positives = 181/424 (42%), Gaps = 25/424 (5%)
Query: 95 DDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVM---KVLL 151
D T LH + N E VK L+ +N + + PLH A + + + +L
Sbjct: 146 DKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCIL 205
Query: 152 EHRTID--VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCF---PIHQAA 206
+ + +N + G T + A N + +L + C + P+H AA
Sbjct: 206 DAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY--ESCNITSYDNLFRTPLHWAA 263
Query: 207 FSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQID 266
G + + ++L E S + + ATPLH A Q+ E +K+ L + + D
Sbjct: 264 LLGHAQIVHLLL----ERNKSGTIPSDSQG---ATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 267 PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELAD 326
+ T+ +AA +G+ ++++ M+S S +DI N D T LH A+L H
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKS-DIDI-NMADKYGGTALHAAALSGHVSTVK 374
Query: 327 YLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQP 386
L+ A ++ D +PL A +++ L+ GA+VD+ D G + LH
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA--- 431
Query: 387 YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 446
G + + +I V +D G TPL A G + L+ N + + K+
Sbjct: 432 LGGNADVCQILIENKINPNV--QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEG 489
Query: 447 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 506
++ LH++ + G ++ +LL D + E + TPL A +V+Q +L+ GA
Sbjct: 490 RTALHWSCNNGYLDAI-KLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Query: 507 LFLS 510
L ++
Sbjct: 549 LSIA 552
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 121 bits (304), Expect = 3e-27
Identities = 100/336 (29%), Positives = 158/336 (47%), Gaps = 17/336 (5%)
Query: 268 VEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI-VNTTDGCHETMLHRASLFDHHELAD 326
+ + + T +HF QG+ E V+L+++ VD+ T G T L A+ +L
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAH---EVDVDCQTASG--YTPLLIAAQDQQPDLCA 412
Query: 327 YLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQP 386
L++ GAD N++D +G +PL A + LLL GA VD ++ G LHL Q
Sbjct: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN 472
Query: 387 YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 446
+ +N+ + Q L + +G TPLH A G V L + ++ ++
Sbjct: 473 F--ENVARLLVSRQADPNL---HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527
Query: 447 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 506
++PLH A G++ Q LL+ + L D G PLH AA G + ++LL+ GA
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDAL---DQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 507 -LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA 565
L L H GWT LH A+ G+ + + ++ +++ L T LH AAR G V+
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN-MGALGAVNWTPLHLAARHGEEAVVS 643
Query: 566 LLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTII 600
LL AD +Q + LHLA+ V+ ++
Sbjct: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679
Score = 116 bits (290), Expect = 1e-25
Identities = 108/405 (26%), Positives = 192/405 (47%), Gaps = 24/405 (5%)
Query: 201 PIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLD 260
P+H GS E + ++L + ++ ++ TPL +A Q+ ++ + L
Sbjct: 365 PLHFLVAQGSVEQVRLLL--------AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
Query: 261 NGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFD 320
+GA + V++ +HFAA G +L++ + VD +G T LH A+ +
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLD-HGACVD-AQEREGW--TPLHLAAQNN 472
Query: 321 HHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLH 380
+A L+S AD N ++EG++PL +A ++V LL S+GA++D + R LH
Sbjct: 473 FENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
Query: 381 LTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIH 440
L V++ G ++ + + + D G PLH A +G LL + S+
Sbjct: 533 LAVER--GKVRAIQHLLKSGAVPDAL---DQSGYGPLHTAAARGKYLICKMLLRYGASLE 587
Query: 441 SKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQL 500
+ +PLH AA G + L + ++ L + TPLHLAA++G + VV
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEEAVVSA 644
Query: 501 LLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559
LL+ GA ++ +GWT LH A ++ +L+ + R ++ G T H AA +G
Sbjct: 645 LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR-NKVGWTPAHLAALKG 703
Query: 560 HAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTIIRSK 603
+ + +L+ A + V + + L LAL + RK+ +++ + K
Sbjct: 704 NTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGK 747
Score = 115 bits (287), Expect = 3e-25
Identities = 114/440 (25%), Positives = 190/440 (43%), Gaps = 66/440 (15%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMD-----DYGNTPLHCAVEKNQIESVKFLLSRG 121
LH+ A+G +E + L + HE+D G TPL A + Q + LL+ G
Sbjct: 366 LHFLVAQGSVEQVR-------LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418
Query: 122 ANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEAL 181
A+ N + + APLH A Q ++ ++LL+H V+ + G T + +A N
Sbjct: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVA 477
Query: 182 QILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT 241
++L+ + A P G P+H AA+ G ++++ G E ++ T
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE--------LDAQQRNLRT 529
Query: 242 PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI 301
PLHLAV+ G + I+ L +GA D +++ +H AA +G I K+++ Y S+++
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-RYGASLEL 588
Query: 302 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361
T G T LH A+ H E+ L A++ + + +PL LA +V+ L
Sbjct: 589 -PTHQGW--TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421
L GA + + G LHL VQ R F+
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQ--------RSTFL------------------------ 673
Query: 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 481
SV NLL + ++H+++K +P H AA G + L++ + L+ D
Sbjct: 674 ------SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ---LDVQDGV 724
Query: 482 GMTPLHLAAKNGHDKVVQLL 501
TPL LA ++ ++ L
Sbjct: 725 SCTPLQLALRSRKQGIMSFL 744
Score = 86.3 bits (212), Expect = 2e-16
Identities = 80/302 (26%), Positives = 131/302 (43%), Gaps = 15/302 (4%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA + + + LHE + G TPLH A + VK L S+GA +
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+ N+ PLH+AV+ ++ LL+ + L+ ++G + A ++LL+
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAARGKYLICKMLLR 581
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA G P+H AA+ G +EII E H ++ + TPLHLA
Sbjct: 582 YGASLELPTHQGWTPLHLAAYKGH---LEIIHLLAESHA-----NMGALGAVNWTPLHLA 633
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
++G+ ++ L GA + E+ T +H A Q +T + + + + +V N
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHL-AVQRSTFLSVINLLEHHANVHARNKVG 692
Query: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
T H A+L + + L+ GA ++ D +PL LA S I++ L K
Sbjct: 693 W---TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEP 749
Query: 367 QV 368
V
Sbjct: 750 SV 751
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 120 bits (301), Expect = 7e-27
Identities = 122/462 (26%), Positives = 203/462 (43%), Gaps = 26/462 (5%)
Query: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
G+ G + D P+ S+ + +A L K + +DT L A
Sbjct: 156 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-KAENSHNAGQVDTRSLAEAC 213
Query: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR-NFN 130
++G + + K+ + ++E + G + L A E + LL+ AN R N
Sbjct: 214 SDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 131 MMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
+ PL A G +++K+LL H DVN + GNTA+ AC + +++LL +GA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
N+ G P+ +AA +G E ++L +HG H N K + L LA G
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINTH---SNEFKESALTLACYKG 383
Query: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
L+M++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 439
Query: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
+ L A+ H ELA LI GA++ +++ EG +PL+ A +V LLL++GA ++
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 500 QTEETQE-TALTLACCGGFSEVADFLIKAGADIEL-------GCSTPLMEASQEGHLELV 551
Query: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
LL ++H+ + + L +A G + LLQ +D
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
Score = 89.7 bits (221), Expect = 1e-17
Identities = 111/454 (24%), Positives = 183/454 (40%), Gaps = 92/454 (20%)
Query: 162 GENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFG 221
G+ ++ AC+ + A++ LL +G + + G + A +G E +++L
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA-- 259
Query: 222 EEHGYSRQLHINFM---NNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHF 278
+H N N G TPL A G L+++K+ L + A ++ TA+ +
Sbjct: 260 --------MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
Query: 279 AATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKI 338
A G +IVK++++ +I + + H ++ AS H E+A L+ GA IN
Sbjct: 312 ACAGGFVDIVKVLLNE---GANIEDHNENGHTPLMEAASA-GHVEVARVLLDHGAGINTH 367
Query: 339 DSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+E + S L LA ++V LL GA + K
Sbjct: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT------------------------- 402
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
DE + T L AC G LL ++ + +SPL AA G
Sbjct: 403 ----------DEMH---TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 449
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF--LSDHNGW 515
+ L++ ++ +N+ G TPL AA+ GH+++V LLL +GA ++
Sbjct: 450 HVELAALLIERGANLEEVND---EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 506
Query: 516 TALHHASMGGYTQTMKVIL----DTNLKCTDRLDE------------------------- 546
TAL A GG+++ ++ D L C+ L E
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 547 DGNTALHFAAREGHAKAVALLLSHNADIVLNKQQ 580
G+TAL +A GH +LL AD L+KQ+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGAD--LDKQE 598
Score = 83.6 bits (205), Expect = 1e-15
Identities = 77/309 (24%), Positives = 147/309 (47%), Gaps = 20/309 (6%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L YA A G +++++ + + + + + ++ G+TPL A +E + LL GA N
Sbjct: 309 LTYACAGGFVDIVKVLLNEGAN--IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366
Query: 127 RNFNMM-APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILL 185
+ + L +A + ++++ LLE D + + +TA++ AC + E ++LL
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGHVEVARLLL 425
Query: 186 KKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
GA+ P+ AA G E +++ G ++ +N+ TPL
Sbjct: 426 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--------NLEEVNDEGYTPLME 477
Query: 246 AVQNGDLEMIKMCLDNGAQIDP-VEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
A + G EM+ + L GA I+ E+ + TA+ A G +E+ +I + +++
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GADIEL--- 533
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
GC T L AS H EL YL++ GA+++ + G + L A + ++ ++LL
Sbjct: 534 --GC-STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Query: 365 GAQVDIKDN 373
GA +D +++
Sbjct: 591 GADLDKQED 599
Score = 81.3 bits (199), Expect = 5e-15
Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A +GD+ ++ LD G ++ + + + A + G E+ +++++ ++ D N
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L AS + ++ L+ AD+N + G + L A A +IV +LL++G
Sbjct: 272 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 329 ANIE--------------------------------------DHNENGHTPLMEAASAGH 350
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G ++ + LL+ +D + ++H T
Sbjct: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 407
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 466
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL+ A+I ++ L L
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 119 bits (298), Expect = 2e-26
Identities = 115/422 (27%), Positives = 190/422 (45%), Gaps = 24/422 (5%)
Query: 52 KQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQI 111
K + +DT L A ++G + + K+ + ++E + G + L A
Sbjct: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYY 240
Query: 112 ESVKFLLSRGANPNLR-NFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVI 170
E + LL+ AN R N + PL A G +++K+LL H DVN + GNTA+
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALT 299
Query: 171 IACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQL 230
AC + +++LL +GA N+ G P+ +AA +G E ++L +HG
Sbjct: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINT 355
Query: 231 HINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKL 290
H N K + L LA G L+M++ L+ GA + TA+ A G E+ +L
Sbjct: 356 H---SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
Query: 291 MISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILAT 350
++ S + VN E+ L A+ H ELA LI GA++ +++ EG +PL+ A
Sbjct: 413 LLDSGAQ----VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
Query: 351 ASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED 410
+V LLL++GA ++ + + LT+ G + ++ EL
Sbjct: 469 REGHEEMVALLLAQGANINAQTEETQE-TALTLACCGGFSEVADFLIKAGADIEL----- 522
Query: 411 NDGC-TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI 469
GC TPL A ++G V LL ++H+ + + L +A G + LLQ
Sbjct: 523 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 470 SD 471
+D
Sbjct: 581 AD 582
Score = 89.7 bits (221), Expect = 1e-17
Identities = 111/454 (24%), Positives = 183/454 (40%), Gaps = 92/454 (20%)
Query: 162 GENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFG 221
G+ ++ AC+ + A++ LL +G + + G + A +G E +++L
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA-- 248
Query: 222 EEHGYSRQLHINFM---NNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHF 278
+H N N G TPL A G L+++K+ L + A ++ TA+ +
Sbjct: 249 --------MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
Query: 279 AATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKI 338
A G +IVK++++ +I + + H ++ AS H E+A L+ GA IN
Sbjct: 301 ACAGGFVDIVKVLLNE---GANIEDHNENGHTPLMEAASA-GHVEVARVLLDHGAGINTH 356
Query: 339 DSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
+E + S L LA ++V LL GA + K
Sbjct: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT------------------------- 391
Query: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
DE + T L AC G LL ++ + +SPL AA G
Sbjct: 392 ----------DEMH---TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 438
Query: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF--LSDHNGW 515
+ L++ ++ +N+ G TPL AA+ GH+++V LLL +GA ++
Sbjct: 439 HVELAALLIERGANLEEVND---EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 495
Query: 516 TALHHASMGGYTQTMKVIL----DTNLKCTDRLDE------------------------- 546
TAL A GG+++ ++ D L C+ L E
Sbjct: 496 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 555
Query: 547 DGNTALHFAAREGHAKAVALLLSHNADIVLNKQQ 580
G+TAL +A GH +LL AD L+KQ+
Sbjct: 556 TGDTALTYACENGHTDVADVLLQAGAD--LDKQE 587
Score = 83.6 bits (205), Expect = 1e-15
Identities = 77/309 (24%), Positives = 147/309 (47%), Gaps = 20/309 (6%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
L YA A G +++++ + + + + + ++ G+TPL A +E + LL GA N
Sbjct: 298 LTYACAGGFVDIVKVLLNEGAN--IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 355
Query: 127 RNFNMM-APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILL 185
+ + L +A + ++++ LLE D + + +TA++ AC + E ++LL
Sbjct: 356 HSNEFKESALTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGHVEVARLLL 414
Query: 186 KKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
GA+ P+ AA G E +++ G ++ +N+ TPL
Sbjct: 415 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--------NLEEVNDEGYTPLME 466
Query: 246 AVQNGDLEMIKMCLDNGAQIDP-VEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
A + G EM+ + L GA I+ E+ + TA+ A G +E+ +I + +++
Sbjct: 467 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GADIEL--- 522
Query: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
GC T L AS H EL YL++ GA+++ + G + L A + ++ ++LL
Sbjct: 523 --GC-STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 579
Query: 365 GAQVDIKDN 373
GA +D +++
Sbjct: 580 GADLDKQED 588
Score = 81.3 bits (199), Expect = 5e-15
Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)
Query: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
A +GD+ ++ LD G ++ + + + A + G E+ +++++ ++ D N
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
D T L AS + ++ L+ AD+N + G + L A A +IV +LL++G
Sbjct: 261 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
A ++ D + +G TPL A G
Sbjct: 318 ANIE--------------------------------------DHNENGHTPLMEAASAGH 339
Query: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
LL I++ S + K+S L A G ++ + LL+ +D + ++H T
Sbjct: 340 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 396
Query: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 397 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 455
Query: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
++++G T L AAREGH + VALLL+ A+I ++ L L
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 111 bits (278), Expect = 3e-24
Identities = 133/618 (21%), Positives = 237/618 (38%), Gaps = 125/618 (20%)
Query: 91 LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150
LH + Y + V + + LL GANPN+++ PLH+++ N V L
Sbjct: 327 LHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQL 386
Query: 151 LEHRTIDVNLEGENGNTAVIIACT------------------------TNNSEALQILLK 186
L+ + +D+ L+ G+TA+ +A NS A +++ +
Sbjct: 387 LQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQR 446
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
G + +AA +G++ + G H+N N TPLH A
Sbjct: 447 GSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNG--------AHVNHRNKWGETPLHTA 498
Query: 247 VQNGDLEMIKMCLDNGAQID-------PVEKGRC------------TAIHFAATQGATEI 287
++G + L GA + P+ K T +H A ++
Sbjct: 499 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 558
Query: 288 VKLMISSYSGSVDIVNT---------TDGCHETMLHRASLFDHHELADYLISVGADINKI 338
V +++ + ++ N D +T+L A H +A L+ GA IN
Sbjct: 559 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT 618
Query: 339 DSEG-------------RSPLILATASASWN---------------------IVNLLLSK 364
S+G +S L L A N +V+ + ++
Sbjct: 619 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTR 678
Query: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQ---------------MQQIKELVMDE 409
GA + + D G L L + L+++ ++ +Q + +DE
Sbjct: 679 GADMSVPDEKGNPPLWLALAN--NLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDE 736
Query: 410 DND--GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467
+N+ C + C P G N +++D ++PLH AAS+G T Q LL+
Sbjct: 737 NNEPTACFLIRSGCDVNSPRQP----GANGEGEEEARDGQTPLHLAASWGLEETVQCLLE 792
Query: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS--DHNGWTALHHASMGG 525
++ +N D G TP+H+A + H ++QLL+ + L+ D G T A
Sbjct: 793 FGAN---VNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFK 849
Query: 526 YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASF-- 583
++ + IL +++D G LH A + ++V L+S +A++ Q AS
Sbjct: 850 NNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLT 909
Query: 584 -LHLALHNKRKEVVLTII 600
LHLA+ + +V ++
Sbjct: 910 PLHLAVQAGSEIIVRNLL 927
Score = 108 bits (270), Expect = 3e-23
Identities = 123/494 (24%), Positives = 203/494 (41%), Gaps = 49/494 (9%)
Query: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNL-RNFNMMAPLHIAVQGMNNEVMKVLLEHRTI 156
G T LH A+++ +S FLL A+ N+ R + L +A++ V+ + R
Sbjct: 622 GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICT-RGA 680
Query: 157 DVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEI 216
D+++ E GN + +A N + L++ G C + WG G C++
Sbjct: 681 DMSVPDEKGNPPLWLALANNLEDIASTLVRHG---CDATCWG---------PGPGGCLQT 728
Query: 217 ILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276
+L H N + T L D+ + NG + G+ T +
Sbjct: 729 LL------------HRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ-TPL 775
Query: 277 HFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLIS-VGADI 335
H AA+ G E V+ ++ + VN D T +H A H + L+S +
Sbjct: 776 HLAASWGLEETVQCLLEFGAN----VNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL 831
Query: 336 NKIDSEGRSPLILATASASWNIVNLLLSK--GAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
N D +G +P A + +L + GA + DN GRNFLH+ VQ ++++
Sbjct: 832 NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV-DNKGRNFLHVAVQNS-DIESVL 889
Query: 394 PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA 453
+ V D TPLH A + G V NLL ++ +K +++ LH A
Sbjct: 890 FLISVHANVNSRVQDASK--LTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLA 947
Query: 454 ASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 513
A C LL++ D ++E +G LHLA +G +++LL + + N
Sbjct: 948 AQQDLPTICSVLLENGVDFAAVDE---NGNNALHLAVMHGRLNNIRVLLTECTVDAEAFN 1004
Query: 514 --GWTALHHASMGGYTQTMKVILDTNLKC-----TDRLDEDGNTALHFAAREGHAKAVAL 566
G + LH G + I D L+C D+ D DG+T L A +G+A
Sbjct: 1005 LRGQSPLHILGQYG-KENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRA 1063
Query: 567 LLSHNADIVLNKQQ 580
++ A + +N Q
Sbjct: 1064 IVRSGARLGVNNNQ 1077
Score = 84.3 bits (207), Expect = 6e-16
Identities = 156/665 (23%), Positives = 249/665 (37%), Gaps = 137/665 (20%)
Query: 53 QKKL----KRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEK 108
QKKL KRC + +++E I + I D L+E + Y + L V
Sbjct: 24 QKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD-----LYEQEQYSD--LKIKVGD 76
Query: 109 NQIESVKFLLS-RGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNT 167
I + KF+L+ R + +L N + L ++ N EV +L D LE +
Sbjct: 77 RHISAHKFVLAARSDSWSLANLSSTKELDLS--DANPEVTMTMLRWIYTD-ELEFREDDV 133
Query: 168 AVIIACTTNNSEALQILLKKGAKPCKS--NKWGCFPIHQAAFSGSKE-----CMEII--- 217
+ N LQ+L ++ K S N C +Q A + C EII
Sbjct: 134 FLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASH 193
Query: 218 ---LRFGEEHGYSRQLHINFMNNGKATPLHLAVQ-------------------------- 248
LR + S QL + + PLH A++
Sbjct: 194 WDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEAD 253
Query: 249 -NGDLEM-----------IKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYS 296
NGDL + + + A +D V+K + +H +G +I + +
Sbjct: 254 HNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGA 313
Query: 297 GSVDIVNT-TDGCHETMLHRASLFDHH-----------ELADYLISVGADINKIDSEGRS 344
VN T G ET LH +L+ ++A+ L+ GA+ N DS+GR+
Sbjct: 314 ----FVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369
Query: 345 PLILATASASWNIVNLLLS-KGAQVDIKDNFGRNFLHLTVQQ--PYGLKNLRPEFMQMQQ 401
PL ++ + + + + LL K +++KD+ G L L VQ +++ P F +
Sbjct: 370 PLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNP-FEDVPV 428
Query: 402 IKELVMDEDN------------------DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 443
+ DE++ G L A G + L ++ ++
Sbjct: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
Query: 444 KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL----------------HGMTPLH 487
K ++PLH A +G N LLQ ++ L E L H TPLH
Sbjct: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
Query: 488 LAAKNGHDKVVQLLLKKGA--------------LFLSDHNGWTALHHASMGGYTQTMKVI 533
+A H VV ++L++ A L D T L A G +
Sbjct: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
Query: 534 LDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQ--ASFLHLALHNK 591
L + D + DG T LH A + +K+ LL H ADI +++ Q + L LA+ N+
Sbjct: 609 LGSGAAINDTMS-DGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
Query: 592 RKEVV 596
VV
Sbjct: 668 LPLVV 672
Score = 51.2 bits (121), Expect = 5e-06
Identities = 51/210 (24%), Positives = 92/210 (43%), Gaps = 17/210 (8%)
Query: 93 EMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR--NFNMMAPLHIAVQGMNNEVMKVL 150
++D+ G LH AV+ + IESV FL+S AN N R + + + PLH+AVQ + +++ L
Sbjct: 867 QVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNL 926
Query: 151 LEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGS 210
L VN ++ TA+ +A + +LL+ G ++ G +H A G
Sbjct: 927 L-LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985
Query: 211 KECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGD------LEMIKMCLDNGAQ 264
+ ++L + N +PLH+ Q G ++ C+ G
Sbjct: 986 LNNIRVLLT-------ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMP-GYP 1037
Query: 265 IDPVEKGRCTAIHFAATQGATEIVKLMISS 294
+D + T + A +G + + ++ S
Sbjct: 1038 LDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
Score = 30.8 bits (68), Expect = 7.5
Identities = 35/156 (22%), Positives = 56/156 (35%), Gaps = 5/156 (3%)
Query: 91 LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150
++E+ + T LH A +++ LL G + + N LH+AV ++VL
Sbjct: 933 VNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVL 992
Query: 151 LEHRTIDVNLEGENGNTAVIIACTTNNSEALQIL-----LKKGAKPCKSNKWGCFPIHQA 205
L T+D G + + I A I G K + G + A
Sbjct: 993 LTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLA 1052
Query: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT 241
G+ I+R G G + +N N AT
Sbjct: 1053 YMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVAT 1088
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 109 bits (273), Expect = 1e-23
Identities = 96/345 (27%), Positives = 158/345 (45%), Gaps = 36/345 (10%)
Query: 168 AVIIACTTNNSEALQILLKKGAK--PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHG 225
A+I A +N LQ LL + + NK G P+ AA G+ + ++++++ G
Sbjct: 347 AIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR-- 404
Query: 226 YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGAT 285
I+ + G + ++ A ++G ++ +K +N +D +K A+H AA G
Sbjct: 405 ------IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHA 458
Query: 286 EIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSP 345
++ +L+ S S N D ET LH A+ ++ +A L G ++N + EG +P
Sbjct: 459 DVAQLLCSFGSNP----NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETP 514
Query: 346 LILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKEL 405
L+ A+A +IV L GA ++ D G LHL V++ QM+ IK L
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-----------CQMEVIKTL 563
Query: 406 VMD------EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRI 459
+ +D G TPLH AC+ G V L N ++ +K ++PLH AA+ G +
Sbjct: 564 LSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Query: 460 NTCQRL-LQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLK 503
+ + L L S L + G T LA H+ V LL +
Sbjct: 624 DVVRYLCLMGASVEALTTD----GKTAEDLARSEQHEHVAGLLAR 664
Score = 99.4 bits (246), Expect = 2e-20
Identities = 73/266 (27%), Positives = 129/266 (48%), Gaps = 13/266 (4%)
Query: 334 DINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLR 393
D+N+ + G PL++A + I+ LL+ +G+++D++D G N ++ + ++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVY------WAARHGH 424
Query: 394 PEFMQMQQIKELVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHF 452
+ ++ + +D +D G LH A R G L F + + + K++++PLH
Sbjct: 425 VDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHC 484
Query: 453 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSD 511
AA +G + + L + + + N G TPL A+ G+ +V+ L + GA L D
Sbjct: 485 AAWHGYYSVAKALCEAGCNVNIKNR---EGETPLLTASARGYHDIVECLAEHGADLNACD 541
Query: 512 HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN 571
+G ALH A + +K +L D D GNT LH A ++G+ V L N
Sbjct: 542 KDGHIALHLAVRRCQMEVIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
Query: 572 ADI-VLNKQQASFLHLALHNKRKEVV 596
++ + NK + LHLA +N +VV
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVV 626
Score = 76.6 bits (187), Expect = 1e-13
Identities = 61/255 (23%), Positives = 114/255 (44%), Gaps = 13/255 (5%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
+++AA G ++ ++ ++ + L D G LH A + + L S G+NPN+
Sbjct: 416 VYWAARHGHVDTLKFLSENKC--PLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNI 473
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
++ PLH A V K L E +VN++ G T ++ A + ++ L +
Sbjct: 474 QDKEEETPLHCAAWHGYYSVAKALCE-AGCNVNIKNREGETPLLTASARGYHDIVECLAE 532
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
GA +K G +H A E ++ +L S+ +++ + TPLH+A
Sbjct: 533 HGADLNACDKDGHIALHLAVRRCQMEVIKTLL--------SQGCFVDYQDRHGNTPLHVA 584
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
++G++ ++ + +D K T +H AA G ++V+ + SV+ + TTD
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR-YLCLMGASVEAL-TTD 642
Query: 307 GCHETMLHRASLFDH 321
G L R+ +H
Sbjct: 643 GKTAEDLARSEQHEH 657
Score = 72.0 bits (175), Expect = 3e-12
Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 11/225 (4%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH AA G ++ + + S + + ++ TPLHCA K L G N N+
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKALCEAGCNVNI 506
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
+N PL A +++++ L EH D+N ++G+ A+ +A E ++ LL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGA-DLNACDKDGHIALHLAVRRCQMEVIKTLLS 565
Query: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
+G ++ G P+H A G+ M I++ E + +++ N TPLHLA
Sbjct: 566 QGCFVDYQDRHGNTPLHVACKDGN---MPIVVALCEAN-----CNLDISNKYGRTPLHLA 617
Query: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
NG L++++ GA ++ + TA A ++ + L+
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 65.1 bits (157), Expect = 4e-10
Identities = 45/128 (35%), Positives = 75/128 (58%), Gaps = 6/128 (4%)
Query: 463 QRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHA 521
Q LL +S+ + N+ + HG PL +AA G+ +++QLL+K+G+ + + D G A++ A
Sbjct: 361 QHLLGSLSNYDV-NQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
Query: 522 SMGGYTQTMKVILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNAD-IVLNKQ 579
+ G+ T+K + + KC D D+ G ALH AAR GHA LL S ++ + +K+
Sbjct: 420 ARHGHVDTLKFLSEN--KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE 477
Query: 580 QASFLHLA 587
+ + LH A
Sbjct: 478 EETPLHCA 485
Score = 64.7 bits (156), Expect = 5e-10
Identities = 67/293 (22%), Positives = 132/293 (45%), Gaps = 17/293 (5%)
Query: 70 AAAEGQIELMEK-ITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRN 128
AA G I++++ I R S ++V D G+ ++ A ++++KFL ++++
Sbjct: 386 AAGCGNIQILQLLIKRGSRIDV---QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 129 FNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKG 188
+ LH+A + + +V ++L + + N++ + T + A + L + G
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGS-NPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 189 AKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQ 248
N+ G P+ A+ G + +E + EHG +N + LHLAV+
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECL----AEHG----ADLNACDKDGHIALHLAVR 553
Query: 249 NGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGC 308
+E+IK L G +D ++ T +H A G IV + + + ++DI N
Sbjct: 554 RCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV-VALCEANCNLDISNKYG-- 610
Query: 309 HETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361
T LH A+ ++ YL +GA + + ++G++ LA + ++ LL
Sbjct: 611 -RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 105 bits (263), Expect = 2e-22
Identities = 106/423 (25%), Positives = 181/423 (42%), Gaps = 57/423 (13%)
Query: 211 KECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA-VQNGDLEMIKMCLDNGAQIDPVE 269
KE E+ FG + +S+ +++N+ + LHL + G I+ + G + +
Sbjct: 40 KELTELRNIFGSDEAFSK-VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLT 98
Query: 270 KGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLI 329
+ TA+H A + E++ ++ S DI G T LH A++ H E AD L+
Sbjct: 99 RNGFTALHLAVYKDNAELITSLLHS---GADIQQVGYG-GLTALHIATIAGHLEAADVLL 154
Query: 330 SVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL 389
GA++N D+ +PL +A + LLL GA V++ G LHL + +
Sbjct: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF-- 212
Query: 390 KNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSP 449
I +L+M+E G ++++ + P
Sbjct: 213 ----------LNIAKLLMEE------------------------GSKADVNAQDNEDHVP 238
Query: 450 LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLK-KGALF 508
LHF + +G + + LLQ + + + +++G TPLHLA NG +V + +++ G
Sbjct: 239 LHFCSRFGHHDIVKYLLQSDLEVQP-HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTES 297
Query: 509 LSDHNGW--TALHHA-SMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA 565
L+ N + TA H A + G +K +LD N+ + DG+T LH A GH + V
Sbjct: 298 LTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQ 357
Query: 566 LLLSHNADIVL----------NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHN 615
LL + AD+ L K + + L A +V + KR + L ++
Sbjct: 358 FLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYS 417
Query: 616 SPG 618
PG
Sbjct: 418 QPG 420
Score = 93.6 bits (231), Expect = 9e-19
Identities = 104/422 (24%), Positives = 168/422 (39%), Gaps = 91/422 (21%)
Query: 91 LHEMDDYGNTPLH-CAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKV 149
L+ + G + LH C + + ++ L+ +G P+ N LH+AV N E++
Sbjct: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
Query: 150 LLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSG 209
LL H D+ G G TA+ IA + EA +LL+ GA + P+H AA+ G
Sbjct: 120 LL-HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
Query: 210 SKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVE 269
++ ++L+FG + +N PLHLA G L + K+ ++ G++ D
Sbjct: 179 HEQVTRLLLKFGAD--------VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD--- 227
Query: 270 KGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLI 329
VN D LH S F HH++ YL+
Sbjct: 228 --------------------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLL 255
Query: 330 SVGADI--NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387
++ + ++ G +PL LA + + + ++ Q
Sbjct: 256 QSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII----------------------QIS 293
Query: 388 GLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG-GPGSVNNLLGFNV-SIHSKSKD 445
G ++L KE + E T H AC G V LL NV +I+ + +D
Sbjct: 294 GTESL---------TKENIFSE-----TAFHSACTYGKSIDLVKFLLDQNVININHQGRD 339
Query: 446 KKSPLHFAASYGRINTCQRLLQDISDTRLL------NEGDLHGMTPLHLAAKNGHDKVVQ 499
+ LH A +G I Q LL + +D L+ + G+ T L A + GHD +V
Sbjct: 340 GHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVT 399
Query: 500 LL 501
LL
Sbjct: 400 LL 401
Score = 80.5 bits (197), Expect = 8e-15
Identities = 75/278 (26%), Positives = 128/278 (46%), Gaps = 19/278 (6%)
Query: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
LH A + EL+ + + + ++ G T LH A +E+ LL GAN N+
Sbjct: 105 LHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162
Query: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
++ PLHIA + +V ++LL+ DVN+ GE G+ + +A ++L++
Sbjct: 163 QDAVFFTPLHIAAYYGHEQVTRLLLKFGA-DVNVSGEVGDRPLHLASAKGFLNIAKLLME 221
Query: 187 KGAKP---CKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPL 243
+G+K + N+ P+H + G + ++ +L+ E Q H+ +N TPL
Sbjct: 222 EGSKADVNAQDNE-DHVPLHFCSRFGHHDIVKYLLQSDLE----VQPHV--VNIYGDTPL 274
Query: 244 HLAVQNGDLEMIKMCLDNGAQIDPVEKG--RCTAIHFAATQG-ATEIVKLMISSYSGSVD 300
HLA NG E+ K + ++ TA H A T G + ++VK ++ +V
Sbjct: 275 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ---NVI 331
Query: 301 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKI 338
+N T LH A H L +L+ GAD+N +
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/159 (27%), Positives = 77/159 (48%), Gaps = 8/159 (5%)
Query: 60 DDMDTFFLHYAAAEGQIELMEKITRDSSLEVL-HEMDDYGNTPLHCAVEKNQIESVKFLL 118
D+ D LH+ + G ++++ + + S LEV H ++ YG+TPLH A + E K ++
Sbjct: 232 DNEDHVPLHFCSRFGHHDIVKYLLQ-SDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
Query: 119 SRGANPNLRNFNMMA--PLHIA-VQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTT 175
+L N+ + H A G + +++K LL+ I++N +G +G+T + AC
Sbjct: 291 QISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYH 350
Query: 176 NNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECM 214
+ +Q LL GA N C P + + C+
Sbjct: 351 GHIRLVQFLLDNGA---DMNLVACDPSRSSGEKDEQTCL 386
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,872,791
Number of Sequences: 37866
Number of extensions: 1802749
Number of successful extensions: 14044
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 4447
Number of HSP's gapped (non-prelim): 3341
length of query: 1119
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1006
effective length of database: 13,968,660
effective search space: 14052471960
effective search space used: 14052471960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.