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Search of human proteins with 116325987
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
(389 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 803 0.0
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 120 2e-27
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 120 2e-27
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 119 6e-27
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 118 8e-27
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 118 8e-27
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 118 8e-27
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 117 1e-26
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 116 3e-26
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 115 9e-26
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 2e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 112 6e-25
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 111 1e-24
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 111 1e-24
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 111 1e-24
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 111 1e-24
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 111 1e-24
gi|155969701 espin-like [Homo sapiens] 105 7e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 103 3e-22
gi|18079216 CASK interacting protein 1 [Homo sapiens] 102 6e-22
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 100 2e-21
gi|110431370 espin [Homo sapiens] 100 4e-21
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 100 4e-21
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 97 2e-20
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 97 3e-20
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 95 1e-19
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 92 6e-19
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 92 6e-19
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 89 5e-18
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 89 9e-18
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 803 bits (2074), Expect = 0.0
Identities = 389/389 (100%), Positives = 389/389 (100%)
Query: 1 MPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITH 60
MPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITH
Sbjct: 1 MPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITH 60
Query: 61 VTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRS 120
VTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRS
Sbjct: 61 VTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRS 120
Query: 121 GVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCF 180
GVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCF
Sbjct: 121 GVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCF 180
Query: 181 KFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG 240
KFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG
Sbjct: 181 KFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG 240
Query: 241 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN
Sbjct: 241 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Query: 301 KAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLC 360
KAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLC
Sbjct: 301 KAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLC 360
Query: 361 LSDLDKTDARRPSKNCRASWSMNDYVEKN 389
LSDLDKTDARRPSKNCRASWSMNDYVEKN
Sbjct: 361 LSDLDKTDARRPSKNCRASWSMNDYVEKN 389
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 120 bits (301), Expect = 2e-27
Identities = 96/314 (30%), Positives = 153/314 (48%), Gaps = 22/314 (7%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F ++H AV + + ++ LL GADI V G TA HIA I G L+
Sbjct: 102 FTALHLAVYKDNAELITS------LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
+GAN+ QD TPLH+AA +GH +++L+ G D +V+ + RP+H A+ G L
Sbjct: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 147 LQLLVKWG--CSIEDVDYNGNLPVHLAAMEGHLHCFKFLV-SRMSSATQVLKAFNDNGEN 203
+LL++ G + D ++P+H + GH K+L+ S + V+ + D +
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 204 VLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKG-DLGMLKKLVEDGVIN 262
+ +F + I G E K+ ET AF H A G + ++K L++ VIN
Sbjct: 276 LACYNGKFEVAKEIIQISGTESLTKENIFSET-AF--HSACTYGKSIDLVKFLLDQNVIN 332
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI-----TNKAGERPSDVAKRFA--- 314
IN + +G T +H A GHI +Q+L+ GAD N+ + +GE+ +A
Sbjct: 333 INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEK 392
Query: 315 -HLAAVKLLEELQK 327
H A V LL+ ++
Sbjct: 393 GHDAIVTLLKHYKR 406
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/225 (21%), Positives = 99/225 (44%), Gaps = 10/225 (4%)
Query: 90 NLTAQDDRGCTPLHLAATHGHSFT-LQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
NL + + G + LHL G + ++ ++ G+ PS + + +H A + +
Sbjct: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 208
L+ G I+ V Y G +H+A + GHL L+ ++ F
Sbjct: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
Query: 209 QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG-VININERA 267
+ +L+F G ++ D+ P H+A+ KG L + K L+E+G ++N +
Sbjct: 179 HEQVTRLLLKFGADVNVSG-EVGDR-----PLHLASAKGFLNIAKLLMEEGSKADVNAQD 232
Query: 268 DNGSTPMHKAAGQGHIECLQWLIK--MGADSNITNKAGERPSDVA 310
+ P+H + GH + +++L++ + ++ N G+ P +A
Sbjct: 233 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 120 bits (301), Expect = 2e-27
Identities = 96/314 (30%), Positives = 153/314 (48%), Gaps = 22/314 (7%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F ++H AV + + ++ LL GADI V G TA HIA I G L+
Sbjct: 203 FTALHLAVYKDNAELITS------LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
+GAN+ QD TPLH+AA +GH +++L+ G D +V+ + RP+H A+ G L
Sbjct: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 316
Query: 147 LQLLVKWG--CSIEDVDYNGNLPVHLAAMEGHLHCFKFLV-SRMSSATQVLKAFNDNGEN 203
+LL++ G + D ++P+H + GH K+L+ S + V+ + D +
Sbjct: 317 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 376
Query: 204 VLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKG-DLGMLKKLVEDGVIN 262
+ +F + I G E K+ ET AF H A G + ++K L++ VIN
Sbjct: 377 LACYNGKFEVAKEIIQISGTESLTKENIFSET-AF--HSACTYGKSIDLVKFLLDQNVIN 433
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI-----TNKAGERPSDVAKRFA--- 314
IN + +G T +H A GHI +Q+L+ GAD N+ + +GE+ +A
Sbjct: 434 INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEK 493
Query: 315 -HLAAVKLLEELQK 327
H A V LL+ ++
Sbjct: 494 GHDAIVTLLKHYKR 507
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/225 (21%), Positives = 99/225 (44%), Gaps = 10/225 (4%)
Query: 90 NLTAQDDRGCTPLHLAATHGHSFT-LQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
NL + + G + LHL G + ++ ++ G+ PS + + +H A + +
Sbjct: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 208
L+ G I+ V Y G +H+A + GHL L+ ++ F
Sbjct: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
Query: 209 QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG-VININERA 267
+ +L+F G ++ D+ P H+A+ KG L + K L+E+G ++N +
Sbjct: 280 HEQVTRLLLKFGADVNVSG-EVGDR-----PLHLASAKGFLNIAKLLMEEGSKADVNAQD 333
Query: 268 DNGSTPMHKAAGQGHIECLQWLIK--MGADSNITNKAGERPSDVA 310
+ P+H + GH + +++L++ + ++ N G+ P +A
Sbjct: 334 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 378
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 119 bits (297), Expect = 6e-27
Identities = 83/276 (30%), Positives = 131/276 (47%), Gaps = 11/276 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GAD+ H G T AA G + V L+ GA + + D G T L +A+ G+
Sbjct: 767 LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN 826
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
++ +L G+D + D W P+H AAF G + L++ G ++D +G +P L
Sbjct: 827 VEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFIL 886
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQ--FIQGAEYEGK 228
A+ EGH C + L+ S+ Q +G N L +A ++I++ F GA+ K
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQ----RGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 229 DLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
D + + TL ++ A + L M + +E+G N+ G T +H + QGH+E +Q
Sbjct: 943 DADGRPTL----YILALENQLTMAEYFLENGA-NVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 289 LIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
LI AD N + A H+ V+LL E
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Score = 96.7 bits (239), Expect = 3e-20
Identities = 75/275 (27%), Positives = 128/275 (46%), Gaps = 8/275 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL +GA + + G T AA G V L+ GA+L +D G TPL LAA GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+ + ++ G + + TD+ W + AA+ G + L+ G ++ D + +
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGK 228
AA GH +++ + +V KA N+ G L A + I++ + GAE +
Sbjct: 651 AAWGGH---EDIVLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHE 706
Query: 229 DLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQ 287
D++ + L+ V A KG ++ L++ G ++ +G TP+ AA +GH++ +
Sbjct: 707 DVDGRTALSVAALCVPASKGHASVVSLLIDRGA-EVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 288 WLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
L++ GAD + T+ G P A H + V L
Sbjct: 766 LLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 70.1 bits (170), Expect = 3e-12
Identities = 43/153 (28%), Positives = 75/153 (49%), Gaps = 2/153 (1%)
Query: 32 DAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANL 91
+A+R ++ +IV L L HGAD+ G +I A+ Q + + NGAN+
Sbjct: 915 NALRVAALEGHRDIVEL--LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV 972
Query: 92 TAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 151
A D G T LH++ GH +Q+++ D + D + + AA+ G + +QLL+
Sbjct: 973 EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Query: 152 KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ G ++ G + +AA EGH+ + L+
Sbjct: 1033 EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 1065
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/141 (26%), Positives = 64/141 (45%)
Query: 43 SEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPL 102
+++ + L +GA++ G TA H++ +G VQ LI A++ A D+ + L
Sbjct: 957 NQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL 1016
Query: 103 HLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDY 162
AA GH +Q+++ G T + + AA G + +Q+L++ G D
Sbjct: 1017 QSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQ 1076
Query: 163 NGNLPVHLAAMEGHLHCFKFL 183
G + +AA GH K L
Sbjct: 1077 FGRTAMRVAAKNGHSQIIKLL 1097
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/250 (20%), Positives = 96/250 (38%), Gaps = 40/250 (16%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + ++I G A +AA+ G V+ L +GA++ +D G L++ A
Sbjct: 895 CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILA 954
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
+ L +G + +D +H + + G + +Q+L+ + + D
Sbjct: 955 LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS 1014
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
+ AA +GH+ + L+ GA +
Sbjct: 1015 ALQSAAWQGHVKVVQLLIE-----------------------------------HGAVVD 1039
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
+ L +AA +G + +++ L+E G + N G T M AA GH + +
Sbjct: 1040 HTCNQGATALC----IAAQEGHIDVVQVLLEHGA-DPNHADQFGRTAMRVAAKNGHSQII 1094
Query: 287 QWLIKMGADS 296
+ L K GA S
Sbjct: 1095 KLLEKYGASS 1104
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 10/146 (6%)
Query: 29 SIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNG 88
++H + G ++ + ++ H AD+ +A AA +G VQ LI +G
Sbjct: 982 ALHVSCWQGHMEMVQVLIAYH------ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHG 1035
Query: 89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
A + ++G T L +AA GH +Q++L G DP+ D+ + AA +G ++
Sbjct: 1036 AVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK 1095
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAME 174
LL K+G S NG P + ME
Sbjct: 1096 LLEKYGAS----SLNGCSPSPVHTME 1117
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 118 bits (296), Expect = 8e-27
Identities = 88/308 (28%), Positives = 140/308 (45%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
A+P + + +H + R G V S LL GA + T +G+T H+AA G
Sbjct: 500 AHPDAATTNGYTPLHISAREGQVDVASV------LLEAGAAHSLATKKGFTPLHVAAKYG 553
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ L+ A + G TPLH+AA + + ++L G P T K + P+H
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 613
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ L+ +G V G P+HLA+ EGH L+ + ++ K+
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
G L LA + K N+ + G D + L + P VA G++ M+ L
Sbjct: 674 ----GLTSLHLAAQEDKVNVADILTK---HGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ G N+N + NG TP+H+AA QGH + L++ GA N T G +AKR +
Sbjct: 727 LKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Query: 316 LAAVKLLE 323
++ V L+
Sbjct: 786 ISVVDTLK 793
Score = 107 bits (266), Expect = 2e-23
Identities = 89/310 (28%), Positives = 143/310 (46%), Gaps = 21/310 (6%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +R F +H A + +K + L+ +GA I +T G T H+AA G
Sbjct: 368 ANPNARALNGFTPLHIACKKNRIK------VMELLVKYGASIQAITESGLTPIHVAAFMG 421
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
V L+ NGA+ + RG T LH+AA G ++ +LR+G + E P+H
Sbjct: 422 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 481
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
A+ G+ +QLL++ + NG P+H++A EG + L+ ++ + K
Sbjct: 482 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK- 540
Query: 197 FNDNGENVLDLAQRFFKQNI----LQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
G L +A ++ ++ LQ A+ GK+ P HVAA + +
Sbjct: 541 ---KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN------GLTPLHVAAHYDNQKVA 591
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
L+E G + + A NG TP+H AA + ++ L+ GA++NI K G P +A +
Sbjct: 592 LLLLEKGA-SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
Query: 313 FAHLAAVKLL 322
H V LL
Sbjct: 651 EGHTDMVTLL 660
Score = 102 bits (254), Expect = 6e-22
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQ 77
N C++ ++ ++H A + G V + E LL G+ + T +G TA HIA++ GQ
Sbjct: 37 NTCNQNGLN--ALHLAAKEGHVGLVQE------LLGRGSSVDSATKKGNTALHIASLAGQ 88
Query: 78 DACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHY 137
V+ L+ GAN+ AQ G TPL++AA H ++ +L +G + S + + P+
Sbjct: 89 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 148
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSA----TQ 192
A G + +L++ D LP +H+AA + L+ +A
Sbjct: 149 ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 203
Query: 193 VLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLG 250
++ ++G L +A + N+ + +GA D + + P HVA+ +G+
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA---AVDFTARNGIT-PLHVASKRGNTN 259
Query: 251 MLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
M+K L++ G I+ + +G TP+H AA GH + ++ L++ GA K G P +A
Sbjct: 260 MVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Query: 311 KRFAHLAAVKLLEELQKYDIDD 332
+ H+ VK L + K +DD
Sbjct: 319 AQGDHVECVKHLLQ-HKAPVDD 339
Score = 100 bits (250), Expect = 2e-21
Identities = 82/300 (27%), Positives = 136/300 (45%), Gaps = 21/300 (7%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F +H A G+V + LL GA + G T H+A+ RG V+ L+
Sbjct: 213 FTPLHIAAHYGNVNVAT------LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 266
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
G + A+ G TPLH AA GH ++++L G K P+H AA + C
Sbjct: 267 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
Query: 147 LQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLD 206
++ L++ ++DV + +H+AA GH K L+ + ++ A NG L
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPLH 382
Query: 207 LAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG----VIN 262
+A + + +++ + +Y E+ P HVAAF G L ++ L+++G V N
Sbjct: 383 IACKKNRIKVMELL--VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
I G T +H AA G +E ++ L++ GA + + + P +A R V+LL
Sbjct: 441 I-----RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/253 (28%), Positives = 119/253 (47%), Gaps = 7/253 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL +GA RG TA H+AA GQ V+ L+ NGA + A+ TPLH+A+ G
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+ +Q++L+ P + P+H +A G++ +L++ G + G P+H+
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA G L K L+ R ++A K NG L +A + Q + + E
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQKVALLL--LEKGASPH 602
Query: 231 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 290
+ P H+AA K + + L+ G N G TP+H A+ +GH + + L+
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 291 KMGADSNITNKAG 303
GA+ +++ K+G
Sbjct: 662 DKGANIHMSTKSG 674
Score = 94.0 bits (232), Expect = 2e-19
Identities = 81/310 (26%), Positives = 137/310 (44%), Gaps = 21/310 (6%)
Query: 21 SRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADI------THVTTRGWTASHIAAI 74
++ KV ++H A R D K + ++ H AD+ T G+T HIAA
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQND----HNADVQSKMMVNRTTESGFTPLHIAAH 221
Query: 75 RGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRP 134
G L+ GA + G TPLH+A+ G++ ++++L G + P
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
Query: 135 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 194
+H AA G ++LL++ G + NG P+H+AA H+ C K L+ + V
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Query: 195 KAFNDNGENVLDLAQR--FFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
+ L +A ++ L + A + L P H+A K + ++
Sbjct: 342 LDY----LTALHVAAHCGHYRVTKLLLDKRANPNARALNG----FTPLHIACKKNRIKVM 393
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
+ LV+ G +I ++G TP+H AA GH+ + L++ GA ++TN GE +A R
Sbjct: 394 ELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
Query: 313 FAHLAAVKLL 322
+ V+ L
Sbjct: 453 AGQVEVVRCL 462
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/298 (24%), Positives = 136/298 (45%), Gaps = 21/298 (7%)
Query: 33 AVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLT 92
A RAG++ ++ E L G DI G A H+AA G VQ L+ G+++
Sbjct: 17 AARAGNLDKVVEY------LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 93 AQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVK 152
+ +G T LH+A+ G + ++++++ G + + + + P++ AA + ++ L++
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 153 WGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFF 212
G + +G P+ +A +GH L+ + L A L +A R
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA--------LHIAARKD 182
Query: 213 KQN----ILQFIQGAEYEGKDLEDQETLA--FPGHVAAFKGDLGMLKKLVEDGVININER 266
+LQ A+ + K + ++ T + P H+AA G++ + L+ G ++
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFT 241
Query: 267 ADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
A NG TP+H A+ +G+ ++ L+ G + + G P A R H V+LL E
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 118 bits (296), Expect = 8e-27
Identities = 88/308 (28%), Positives = 140/308 (45%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
A+P + + +H + R G V S LL GA + T +G+T H+AA G
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASV------LLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ L+ A + G TPLH+AA + + ++L G P T K + P+H
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ L+ +G V G P+HLA+ EGH L+ + ++ K+
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
G L LA + K N+ + G D + L + P VA G++ M+ L
Sbjct: 695 ----GLTSLHLAAQEDKVNVADILTK---HGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ G N+N + NG TP+H+AA QGH + L++ GA N T G +AKR +
Sbjct: 748 LKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 316 LAAVKLLE 323
++ V L+
Sbjct: 807 ISVVDTLK 814
Score = 107 bits (266), Expect = 2e-23
Identities = 89/310 (28%), Positives = 143/310 (46%), Gaps = 21/310 (6%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +R F +H A + +K + L+ +GA I +T G T H+AA G
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIK------VMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
V L+ NGA+ + RG T LH+AA G ++ +LR+G + E P+H
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
A+ G+ +QLL++ + NG P+H++A EG + L+ ++ + K
Sbjct: 503 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK- 561
Query: 197 FNDNGENVLDLAQRFFKQNI----LQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
G L +A ++ ++ LQ A+ GK+ P HVAA + +
Sbjct: 562 ---KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN------GLTPLHVAAHYDNQKVA 612
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
L+E G + + A NG TP+H AA + ++ L+ GA++NI K G P +A +
Sbjct: 613 LLLLEKGA-SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 313 FAHLAAVKLL 322
H V LL
Sbjct: 672 EGHTDMVTLL 681
Score = 102 bits (254), Expect = 6e-22
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQ 77
N C++ ++ ++H A + G V + E LL G+ + T +G TA HIA++ GQ
Sbjct: 58 NTCNQNGLN--ALHLAAKEGHVGLVQE------LLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 78 DACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHY 137
V+ L+ GAN+ AQ G TPL++AA H ++ +L +G + S + + P+
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSA----TQ 192
A G + +L++ D LP +H+AA + L+ +A
Sbjct: 170 ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 193 VLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLG 250
++ ++G L +A + N+ + +GA D + + P HVA+ +G+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA---AVDFTARNGIT-PLHVASKRGNTN 280
Query: 251 MLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
M+K L++ G I+ + +G TP+H AA GH + ++ L++ GA K G P +A
Sbjct: 281 MVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Query: 311 KRFAHLAAVKLLEELQKYDIDD 332
+ H+ VK L + K +DD
Sbjct: 340 AQGDHVECVKHLLQ-HKAPVDD 360
Score = 100 bits (250), Expect = 2e-21
Identities = 82/300 (27%), Positives = 136/300 (45%), Gaps = 21/300 (7%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F +H A G+V + LL GA + G T H+A+ RG V+ L+
Sbjct: 234 FTPLHIAAHYGNVNVAT------LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 287
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
G + A+ G TPLH AA GH ++++L G K P+H AA + C
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 147 LQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLD 206
++ L++ ++DV + +H+AA GH K L+ + ++ A NG L
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPLH 403
Query: 207 LAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG----VIN 262
+A + + +++ + +Y E+ P HVAAF G L ++ L+++G V N
Sbjct: 404 IACKKNRIKVMELL--VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
I G T +H AA G +E ++ L++ GA + + + P +A R V+LL
Sbjct: 462 I-----RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/253 (28%), Positives = 119/253 (47%), Gaps = 7/253 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL +GA RG TA H+AA GQ V+ L+ NGA + A+ TPLH+A+ G
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+ +Q++L+ P + P+H +A G++ +L++ G + G P+H+
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA G L K L+ R ++A K NG L +A + Q + + E
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQKVALLL--LEKGASPH 623
Query: 231 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 290
+ P H+AA K + + L+ G N G TP+H A+ +GH + + L+
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 291 KMGADSNITNKAG 303
GA+ +++ K+G
Sbjct: 683 DKGANIHMSTKSG 695
Score = 94.0 bits (232), Expect = 2e-19
Identities = 81/310 (26%), Positives = 137/310 (44%), Gaps = 21/310 (6%)
Query: 21 SRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADI------THVTTRGWTASHIAAI 74
++ KV ++H A R D K + ++ H AD+ T G+T HIAA
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQND----HNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 75 RGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRP 134
G L+ GA + G TPLH+A+ G++ ++++L G + P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 135 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 194
+H AA G ++LL++ G + NG P+H+AA H+ C K L+ + V
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 195 KAFNDNGENVLDLAQR--FFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
+ L +A ++ L + A + L P H+A K + ++
Sbjct: 363 LDY----LTALHVAAHCGHYRVTKLLLDKRANPNARALNG----FTPLHIACKKNRIKVM 414
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
+ LV+ G +I ++G TP+H AA GH+ + L++ GA ++TN GE +A R
Sbjct: 415 ELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 313 FAHLAAVKLL 322
+ V+ L
Sbjct: 474 AGQVEVVRCL 483
Score = 87.8 bits (216), Expect = 2e-17
Identities = 77/326 (23%), Positives = 144/326 (44%), Gaps = 21/326 (6%)
Query: 5 ANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR 64
++SG + +K S A RAG++ ++ E L G DI
Sbjct: 10 SDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEY------LKGGIDINTCNQN 63
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G A H+AA G VQ L+ G+++ + +G T LH+A+ G + ++++++ G +
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ + + P++ AA + ++ L++ G + +G P+ +A +GH L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 185 SRMSSATQVLKAFNDNGENVLDLAQRFFKQN----ILQFIQGAEYEGKDLEDQETLA--F 238
+ L A L +A R +LQ A+ + K + ++ T +
Sbjct: 184 ENDTKGKVRLPA--------LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 239 PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
P H+AA G++ + L+ G ++ A NG TP+H A+ +G+ ++ L+ G +
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 299 TNKAGERPSDVAKRFAHLAAVKLLEE 324
+ G P A R H V+LL E
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLE 320
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 118 bits (296), Expect = 8e-27
Identities = 88/308 (28%), Positives = 140/308 (45%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
A+P + + +H + R G V S LL GA + T +G+T H+AA G
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASV------LLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ L+ A + G TPLH+AA + + ++L G P T K + P+H
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ L+ +G V G P+HLA+ EGH L+ + ++ K+
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
G L LA + K N+ + G D + L + P VA G++ M+ L
Sbjct: 695 ----GLTSLHLAAQEDKVNVADILTK---HGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ G N+N + NG TP+H+AA QGH + L++ GA N T G +AKR +
Sbjct: 748 LKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 316 LAAVKLLE 323
++ V L+
Sbjct: 807 ISVVDTLK 814
Score = 107 bits (266), Expect = 2e-23
Identities = 89/310 (28%), Positives = 143/310 (46%), Gaps = 21/310 (6%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +R F +H A + +K + L+ +GA I +T G T H+AA G
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIK------VMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
V L+ NGA+ + RG T LH+AA G ++ +LR+G + E P+H
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
A+ G+ +QLL++ + NG P+H++A EG + L+ ++ + K
Sbjct: 503 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK- 561
Query: 197 FNDNGENVLDLAQRFFKQNI----LQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
G L +A ++ ++ LQ A+ GK+ P HVAA + +
Sbjct: 562 ---KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN------GLTPLHVAAHYDNQKVA 612
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
L+E G + + A NG TP+H AA + ++ L+ GA++NI K G P +A +
Sbjct: 613 LLLLEKGA-SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 313 FAHLAAVKLL 322
H V LL
Sbjct: 672 EGHTDMVTLL 681
Score = 102 bits (254), Expect = 6e-22
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQ 77
N C++ ++ ++H A + G V + E LL G+ + T +G TA HIA++ GQ
Sbjct: 58 NTCNQNGLN--ALHLAAKEGHVGLVQE------LLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 78 DACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHY 137
V+ L+ GAN+ AQ G TPL++AA H ++ +L +G + S + + P+
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSA----TQ 192
A G + +L++ D LP +H+AA + L+ +A
Sbjct: 170 ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 193 VLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLG 250
++ ++G L +A + N+ + +GA D + + P HVA+ +G+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA---AVDFTARNGIT-PLHVASKRGNTN 280
Query: 251 MLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
M+K L++ G I+ + +G TP+H AA GH + ++ L++ GA K G P +A
Sbjct: 281 MVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Query: 311 KRFAHLAAVKLLEELQKYDIDD 332
+ H+ VK L + K +DD
Sbjct: 340 AQGDHVECVKHLLQ-HKAPVDD 360
Score = 100 bits (250), Expect = 2e-21
Identities = 82/300 (27%), Positives = 136/300 (45%), Gaps = 21/300 (7%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F +H A G+V + LL GA + G T H+A+ RG V+ L+
Sbjct: 234 FTPLHIAAHYGNVNVAT------LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 287
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
G + A+ G TPLH AA GH ++++L G K P+H AA + C
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 147 LQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLD 206
++ L++ ++DV + +H+AA GH K L+ + ++ A NG L
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP----NARALNGFTPLH 403
Query: 207 LAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG----VIN 262
+A + + +++ + +Y E+ P HVAAF G L ++ L+++G V N
Sbjct: 404 IACKKNRIKVMELL--VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
I G T +H AA G +E ++ L++ GA + + + P +A R V+LL
Sbjct: 462 I-----RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/253 (28%), Positives = 119/253 (47%), Gaps = 7/253 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL +GA RG TA H+AA GQ V+ L+ NGA + A+ TPLH+A+ G
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+ +Q++L+ P + P+H +A G++ +L++ G + G P+H+
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA G L K L+ R ++A K NG L +A + Q + + E
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQKVALLL--LEKGASPH 623
Query: 231 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 290
+ P H+AA K + + L+ G N G TP+H A+ +GH + + L+
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 291 KMGADSNITNKAG 303
GA+ +++ K+G
Sbjct: 683 DKGANIHMSTKSG 695
Score = 94.0 bits (232), Expect = 2e-19
Identities = 81/310 (26%), Positives = 137/310 (44%), Gaps = 21/310 (6%)
Query: 21 SRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADI------THVTTRGWTASHIAAI 74
++ KV ++H A R D K + ++ H AD+ T G+T HIAA
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQND----HNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 75 RGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRP 134
G L+ GA + G TPLH+A+ G++ ++++L G + P
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 135 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 194
+H AA G ++LL++ G + NG P+H+AA H+ C K L+ + V
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 195 KAFNDNGENVLDLAQR--FFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGML 252
+ L +A ++ L + A + L P H+A K + ++
Sbjct: 363 LDY----LTALHVAAHCGHYRVTKLLLDKRANPNARALNG----FTPLHIACKKNRIKVM 414
Query: 253 KKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKR 312
+ LV+ G +I ++G TP+H AA GH+ + L++ GA ++TN GE +A R
Sbjct: 415 ELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 313 FAHLAAVKLL 322
+ V+ L
Sbjct: 474 AGQVEVVRCL 483
Score = 87.8 bits (216), Expect = 2e-17
Identities = 77/326 (23%), Positives = 144/326 (44%), Gaps = 21/326 (6%)
Query: 5 ANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR 64
++SG + +K S A RAG++ ++ E L G DI
Sbjct: 10 SDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEY------LKGGIDINTCNQN 63
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G A H+AA G VQ L+ G+++ + +G T LH+A+ G + ++++++ G +
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ + + P++ AA + ++ L++ G + +G P+ +A +GH L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 185 SRMSSATQVLKAFNDNGENVLDLAQRFFKQN----ILQFIQGAEYEGKDLEDQETLA--F 238
+ L A L +A R +LQ A+ + K + ++ T +
Sbjct: 184 ENDTKGKVRLPA--------LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 239 PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
P H+AA G++ + L+ G ++ A NG TP+H A+ +G+ ++ L+ G +
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 299 TNKAGERPSDVAKRFAHLAAVKLLEE 324
+ G P A R H V+LL E
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLE 320
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 117 bits (294), Expect = 1e-26
Identities = 76/275 (27%), Positives = 132/275 (48%), Gaps = 9/275 (3%)
Query: 50 WLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHG 109
+LL HGA ++ T +G+T H+AA G+ L+ A+ A G TPLH+AA +
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
Query: 110 HSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVH 169
+ ++L G P K + P+H AA ++ L+++G V G VH
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 170 LAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKD 229
LAA EGH+ L+ R ++ + N +G L LA + + N+ + + +G
Sbjct: 670 LAAQEGHVDMVSLLLGRNAN----VNLSNKSGLTPLHLAAQEDRVNVAEVLVN---QGAH 722
Query: 230 LEDQETLAF-PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
++ Q + + P HV G++ ++ L++ +N + NG TP+H+AA QGH +
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA-KVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 289 LIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLE 323
L++ A N G +A+R +++ V L+
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
Score = 117 bits (292), Expect = 2e-26
Identities = 88/300 (29%), Positives = 148/300 (49%), Gaps = 19/300 (6%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H R+G +Q+ E+ LL A I T G + H+A CVQ L+ +
Sbjct: 305 LHCGARSGH-EQVVEM-----LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ + T LH+AA GH +++L +P+ + P+H A R+ ++L
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+K G SI+ V +G P+H+AA GH++ +VS++ N GE L +A
Sbjct: 419 LLKHGASIQAVTESGLTPIHVAAFMGHVN----IVSQLMHHGASPNTTNVRGETALHMAA 474
Query: 210 RFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERA 267
R + +++++ GA+ E K +DQ P H++A G ++++L++ G + N
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQT----PLHISARLGKADIVQQLLQQGA-SPNAAT 529
Query: 268 DNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQK 327
+G TP+H +A +GH + +L+ GA +IT K G P VA ++ L LL LQK
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL--LQK 587
Score = 110 bits (275), Expect = 2e-24
Identities = 87/306 (28%), Positives = 142/306 (46%), Gaps = 13/306 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP ++ F +H A + +K + LL HGA I VT G T H+AA G
Sbjct: 391 ANPNAKALNGFTPLHIACKKNRIK------VMELLLKHGASIQAVTESGLTPIHVAAFMG 444
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
V L+ +GA+ + RG T LH+AA G + ++ +++ G K + P+H
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
+A G+ +Q L++ G S +G P+HL+A EGH FL+ +S + K
Sbjct: 505 ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK- 563
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLV 256
G L +A ++ K + + + D + L P HVAA + + L+
Sbjct: 564 ---KGFTPLHVAAKYGKLEVANLLL-QKSASPDAAGKSGLT-PLHVAAHYDNQKVALLLL 618
Query: 257 EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHL 316
+ G + + A NG TP+H AA + ++ L++ GAD+N + G +A + H+
Sbjct: 619 DQGA-SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
Query: 317 AAVKLL 322
V LL
Sbjct: 678 DMVSLL 683
Score = 100 bits (249), Expect = 2e-21
Identities = 85/306 (27%), Positives = 145/306 (47%), Gaps = 21/306 (6%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQ 77
N C++ ++ ++H A + G V+ +SE LL A++ T +G TA HIA++ GQ
Sbjct: 68 NICNQNGLN--ALHLASKEGHVEVVSE------LLQREANVDAATKKGNTALHIASLAGQ 119
Query: 78 DACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHY 137
V+ L+ NGAN+ AQ G TPL++AA H ++ +L +G S+ + + P+
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAV 179
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
A G + LL++ D LP +H+AA + L+ ++A K
Sbjct: 180 ALQQGHDQVVSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK- 233
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLV 256
+G L +A + N+ + D + + P HVA+ +G+ M+K L+
Sbjct: 234 ---SGFTPLHIAAHYGNINVATLLLN-RAAAVDFTARNDIT-PLHVASKRGNANMVKLLL 288
Query: 257 EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHL 316
+ G I+ + +G TP+H A GH + ++ L+ A K G P +A + HL
Sbjct: 289 DRGA-KIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347
Query: 317 AAVKLL 322
V+LL
Sbjct: 348 NCVQLL 353
Score = 97.1 bits (240), Expect = 2e-20
Identities = 80/302 (26%), Positives = 127/302 (42%), Gaps = 18/302 (5%)
Query: 68 ASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVT 127
A HIAA + L+ N N + G TPLH+AA +G+ ++L T
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 128 DKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRM 187
+ + P+H A+ G ++LL+ G I+ +G P+H A GH + L+ R
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 188 SSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKG 247
+ K NG + L +A + N +Q + D+ + A HVAA G
Sbjct: 325 APILSKTK----NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTAL--HVAAHCG 378
Query: 248 DLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPS 307
+ K L+ D N N +A NG TP+H A + I+ ++ L+K GA ++G P
Sbjct: 379 HYKVAKVLL-DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Query: 308 DVAKRFAHLAAVKLL----EELQKYDIDDENEI-------DENDVKYFIRHGVEGSTDAK 356
VA H+ V L ++ E + V+Y ++ G + AK
Sbjct: 438 HVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
Query: 357 DD 358
DD
Sbjct: 498 DD 499
Score = 93.6 bits (231), Expect = 3e-19
Identities = 81/300 (27%), Positives = 132/300 (44%), Gaps = 15/300 (5%)
Query: 24 KVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQA 83
K F +H A G++ + LL A + T H+A+ RG V+
Sbjct: 233 KSGFTPLHIAAHYGNINVAT------LLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143
L+ GA + A+ G TPLH A GH ++++L K P+H A
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 144 LGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGEN 203
L C+QLL++ ++DV + +H+AA GH K L+ + A KA NG
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK--KANPNAKAL--NGFT 402
Query: 204 VLDLAQRFFKQNILQFIQGAEYEGKDLED-QETLAFPGHVAAFKGDLGMLKKLVEDGVIN 262
L +A K+N ++ ++ G ++ E+ P HVAAF G + ++ +L+ G +
Sbjct: 403 PLHIA---CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA-S 458
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
N G T +H AA G E +++L++ GA K + P ++ R V+ L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Score = 58.2 bits (139), Expect = 1e-08
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 40/174 (22%)
Query: 151 VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQR 210
+K G I + NG +HLA+ EGH+ L+ R ++ K G L
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK----KGNTAL----- 111
Query: 211 FFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNG 270
H+A+ G ++K LV +G N+N ++ NG
Sbjct: 112 ------------------------------HIASLAGQAEVVKVLVTNGA-NVNAQSQNG 140
Query: 271 STPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
TP++ AA + H+E +++L+ GA ++ + G P VA + H V LL E
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194
Score = 35.4 bits (80), Expect = 0.088
Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 6/90 (6%)
Query: 21 SRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDAC 80
++ K+ + +H G++K +++LL H A + T G+T H AA +G
Sbjct: 725 AQTKMGYTPLHVGCHYGNIK------IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778
Query: 81 VQALIMNGANLTAQDDRGCTPLHLAATHGH 110
+ L+ N A+ G T L +A G+
Sbjct: 779 INVLLQNNASPNELTVNGNTALGIARRLGY 808
Score = 29.3 bits (64), Expect = 6.3
Identities = 17/47 (36%), Positives = 23/47 (48%)
Query: 276 KAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+AA GH+E IK G D NI N+ G +A + H+ V L
Sbjct: 47 RAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 116 bits (291), Expect = 3e-26
Identities = 82/314 (26%), Positives = 142/314 (45%), Gaps = 52/314 (16%)
Query: 9 PSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTA 68
PSTS T + +K V DA+ +GD +L +I+ D+ G +
Sbjct: 395 PSTSDLGTTDVQKKKLV------DAIVSGDTSKLMKIL-------QPQDVDLALDSGASL 441
Query: 69 SHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTD 128
H+A GQ+ C + L++N AN + RG TPLH+A ++++L + + D
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 129 KREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMS 188
+ +W +H+AA +G +LL++ S+ +VD+ G P+H+A G + + L+ R
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR-- 559
Query: 189 SATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGD 248
G +V +GKD P H AA++G
Sbjct: 560 ------------GVDV-------------------SLQGKD------AWLPLHYAAWQGH 582
Query: 249 LGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSD 308
L ++K L + +++N + +G TP+H AA +GH + LI + +D N+ + + P
Sbjct: 583 LPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLH 642
Query: 309 VAKRFAHLAAVKLL 322
VA H + +LL
Sbjct: 643 VAAETGHTSTARLL 656
Score = 103 bits (257), Expect = 3e-22
Identities = 80/294 (27%), Positives = 118/294 (40%), Gaps = 51/294 (17%)
Query: 66 WTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPS 125
WTA H AA G ++ + L+ A++ D G TP+H+A HG ++I+LR GVD S
Sbjct: 505 WTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVS 564
Query: 126 VTDKREWRPVHYAAFHGRLGCLQLLVKW-GCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K W P+HYAA+ G L ++LL K G S+ +G P+HLAA GH + L+
Sbjct: 565 LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI 624
Query: 185 SRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAA 244
S NV L + P HVAA
Sbjct: 625 DLCSDV------------NVCSLLAQT---------------------------PLHVAA 645
Query: 245 FKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGE 304
G + L+ G +G T +H AA GH+ ++ L++ AD +
Sbjct: 646 ETGHTSTARLLLHRGA-GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704
Query: 305 RPSDVAKRFAHLAAVKLLEELQKYDIDDENEID----------ENDVKYFIRHG 348
+A H V+ L D+ DE + V+ +RHG
Sbjct: 705 TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 53.1 bits (126), Expect = 4e-07
Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 1/129 (0%)
Query: 56 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQ 115
+D+ + T H+AA G + + L+ GA A G T LHLAA +GH T++
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVK 687
Query: 116 IMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEG 175
+++ D +H AA HG ++ LV I+ D G +HLAA
Sbjct: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGR 746
Query: 176 HLHCFKFLV 184
H + L+
Sbjct: 747 HAQTVETLL 755
Score = 52.0 bits (123), Expect = 9e-07
Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA +T+ G+TA H+AA G A V+ L+ A++ A+ T LHLAA HGH
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSI 157
S ++ ++ + V + D++ +H AA ++ L++ G I
Sbjct: 716 SEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761
Score = 41.2 bits (95), Expect = 0.002
Identities = 46/216 (21%), Positives = 83/216 (38%), Gaps = 60/216 (27%)
Query: 186 RMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAF 245
R+S + V AF+ G L+ F ++ + + + K L D A
Sbjct: 370 RLSGVSSVDSAFSSRGS----LSLSFEREPSTSDLGTTDVQKKKLVD----------AIV 415
Query: 246 KGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGER 305
GD L K+++ +++ D+G++ +H A G EC +WL+ A+ N++N+ G
Sbjct: 416 SGDTSKLMKILQPQDVDL--ALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGST 473
Query: 306 PSDVA--KRFAHLAAVKLLEELQKYDIDDE---------------------------NEI 336
P +A +R + + L ++ D++ NE+
Sbjct: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533
Query: 337 D---------------ENDVKYFIRHGVEGSTDAKD 357
D EN V+ +R GV+ S KD
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKD 569
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 115 bits (287), Expect = 9e-26
Identities = 90/297 (30%), Positives = 139/297 (46%), Gaps = 28/297 (9%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
+G +H A +G ++ + +LL GA+I G TA HIA GQDA L+
Sbjct: 207 YGLLHTAAASGQIEVVK------YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN 260
Query: 87 NGANLTAQDDRGCTPLHLAA--THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
GAN+ +D+G TPLH+AA T+G + L++++ +G D + K P+H AA HGR
Sbjct: 261 AGANVNQPNDKGFTPLHVAAVSTNG-ALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRF 319
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQ------------ 192
Q+L++ G I+ D GN P+H+AA GH L++ + +
Sbjct: 320 TRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379
Query: 193 VLKAFNDNGENVLDLAQRFFKQNILQFIQGAEY--EGKDLEDQETLAFPG-HVAAFKGDL 249
VL F+D +L Q + +I+ + G D+ + L H AA G++
Sbjct: 380 VLFGFSDCCRKLLSSGQLY---SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNV 436
Query: 250 GMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP 306
L L+ G ++ R G TP+H AA G +C L+ GA N + G P
Sbjct: 437 ECLNLLLSSGA-DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492
Score = 109 bits (272), Expect = 5e-24
Identities = 82/273 (30%), Positives = 127/273 (46%), Gaps = 8/273 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL H AD+ T H+AA C +AL ++L D G + LH A GH
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH 152
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
T+ ++L G +V DK+E +P+H+AAF G L L+LLV G + D G +H
Sbjct: 153 LETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHT 212
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA G + K+L+ RM + AF G L +A + + + A G ++
Sbjct: 213 AAASGQIEVVKYLL-RMGAEIDEPNAF---GNTALHIACYLGQDAVAIELVNA---GANV 265
Query: 231 EDQETLAF-PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
F P HVAA + + +L+ + ++N ++ G +P+H AA G Q L
Sbjct: 266 NQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
I+ G++ + +K G P VA R+ H + L
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Score = 102 bits (253), Expect = 8e-22
Identities = 88/311 (28%), Positives = 136/311 (43%), Gaps = 53/311 (17%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A G+V+ CL+ LL GAD+ G T H AA G C L+ GA
Sbjct: 427 LHAAASGGNVE------CLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
Query: 90 NLTAQDDRGCTPLHLAAT---------HGHS-------------------FTLQIMLRSG 121
+ D +GC+PLH AA H S F L+ +L +G
Sbjct: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540
Query: 122 VDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCS-IEDVDYNGNL-PVHLAAMEGHLHC 179
DPS+ D++ + VHYAA +G L+LL++ + +EDV+ + P+HLAA GH
Sbjct: 541 ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEA 600
Query: 180 FKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFP 239
K L + + L + G L LA ++ + A +++++ P
Sbjct: 601 LKTLAETLVN----LDVRDHKGRTALFLATERGSTECVEVLT-AHGASALIKERKRKWTP 655
Query: 240 GHVAAFKGDLGMLKKLVEDGVININERAD-------NGSTPMHKAAGQGHIECLQWLIKM 292
H AA G L L++ G ERAD G TP+ A GH++C+ L++
Sbjct: 656 LHAAAASGHTDSLHLLIDSG-----ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 293 GADSNITNKAG 303
G+ ++ + G
Sbjct: 711 GSTADAADLRG 721
Score = 93.6 bits (231), Expect = 3e-19
Identities = 86/307 (28%), Positives = 129/307 (42%), Gaps = 52/307 (16%)
Query: 67 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
T H AA G +Q L+M+GAN+ A+D TPLH AA + L ++L D +
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
Query: 127 TDKREWRPVHYAAFH---------------------------------GRLGCLQLLVKW 153
DK P+H AA + G L + LL+
Sbjct: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
Query: 154 GCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFK 213
G S+ D P+H AA GHL K LV+R + L + G +L A +
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD----LGCKDRKGYGLLHTAAASGQ 218
Query: 214 QNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGS 271
+++++ GAE + + L H+A + G + +LV G N+N+ D G
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTAL----HIACYLGQDAVAIELVNAGA-NVNQPNDKGF 273
Query: 272 TPMHKAA-GQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQKYDI 330
TP+H AA CL+ L+ GAD N +K G+ P H+AA+ + I
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP-------LHMAAIHGRFTRSQILI 326
Query: 331 DDENEID 337
+ +EID
Sbjct: 327 QNGSEID 333
Score = 90.1 bits (222), Expect = 3e-18
Identities = 76/286 (26%), Positives = 125/286 (43%), Gaps = 30/286 (10%)
Query: 42 LSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTP 101
L + L L+ GAD+ +G+ H AA GQ V+ L+ GA + + G T
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
Query: 102 LHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAF--HGRLGCLQLLVKWGCSIED 159
LH+A G ++ +G + + + + + P+H AA +G L CL+LLV G +
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY 301
Query: 160 VDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQF 219
G P+H+AA+ G + L+ S + + G L +A R+ + ++
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSE----IDCADKFGNTPLHVAARYGHELLIST 357
Query: 220 I--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVI---------------- 261
+ GA+ + + D FP H+A G +KL+ G +
Sbjct: 358 LMTNGADTARRGIHDM----FPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAG 413
Query: 262 -NINERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP 306
+IN + G T +H AA G++ECL L+ GAD +K G P
Sbjct: 414 FDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
Score = 88.6 bits (218), Expect = 9e-18
Identities = 71/283 (25%), Positives = 132/283 (46%), Gaps = 12/283 (4%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+H LL G+ RG TA H A+ G + C+ AL+ + A + +D +G TP+HLA+
Sbjct: 703 CVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS 762
Query: 107 THGHSFTLQIMLRSGV--DP--SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDY 162
GH+ L+ +L++ + DP + D + P+H+A++ G CL+LL++ ++
Sbjct: 763 ACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS-PFSYLEG 821
Query: 163 NGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQG 222
N P+H A + + L+ + + +++ + + G L A F N+
Sbjct: 822 NPFTPLHCAVINNQDSTTEMLLGALGA--KIVNSRDAKGRTPLHAAA--FADNVSGLRML 877
Query: 223 AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGH 282
+++ + T AA G ++ L+ G ++ +N +T +H A +GH
Sbjct: 878 LQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH 937
Query: 283 IECLQWLIKMGAD---SNITNKAGERPSDVAKRFAHLAAVKLL 322
+C ++ D N TN A + P +A R + V+ L
Sbjct: 938 EKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980
Score = 82.0 bits (201), Expect = 8e-16
Identities = 81/297 (27%), Positives = 122/297 (41%), Gaps = 12/297 (4%)
Query: 47 CLHWLLWHGAD-ITHVTTRGWTASHIAAIRGQDACVQALIMNG--ANLT-AQDDRGCTPL 102
C+ L HGA + R WT H AA G + LI +G A++T D G TPL
Sbjct: 633 CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692
Query: 103 HLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDY 162
LA +GH + ++L G D R +H A G CL L+ + D+
Sbjct: 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
Query: 163 NGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQG 222
G P+HLA+ GH + L+ S + + +G + + A ++ L+ +
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL-- 810
Query: 223 AEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKLVED-GVININERADNGSTPMHKAAGQ 280
E E F P H A + L+ G +N R G TP+H AA
Sbjct: 811 --LEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFA 868
Query: 281 GHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQKYDID--DENE 335
++ L+ L++ A+ N T+ G A AAV+ L K D+ DEN+
Sbjct: 869 DNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK 925
Score = 79.0 bits (193), Expect = 7e-15
Identities = 91/349 (26%), Positives = 138/349 (39%), Gaps = 55/349 (15%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G +S L+ +GAD H+A + G C + L+ +G
Sbjct: 343 LHVAARYGHELLIST------LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQ 396
Query: 90 ------------------NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE 131
++ D+ G T LH AA+ G+ L ++L SG D DK
Sbjct: 397 LYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFG 456
Query: 132 WRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAA-------MEGHLHCF---- 180
P+HYAA +G C LV G + + D G P+H AA E H
Sbjct: 457 RTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE 516
Query: 181 ---KFLVSRMSSATQVLKAFNDNGEN----------VLDLAQRFFKQNILQFIQGAEYEG 227
SR A L+ DNG + + A + + L+ + E
Sbjct: 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL--LEMSF 574
Query: 228 KDLEDQETL--AFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIEC 285
LED E+ P H+AA+ G LK L E ++N++ R G T + A +G EC
Sbjct: 575 NCLEDVESTIPVSPLHLAAYNGHCEALKTLAET-LVNLDVRDHKGRTALFLATERGSTEC 633
Query: 286 LQWLIKMGADSNITNKAGE-RPSDVAKRFAHLAAVKLL-EELQKYDIDD 332
++ L GA + I + + P A H ++ LL + ++ DI D
Sbjct: 634 VEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITD 682
Score = 75.1 bits (183), Expect = 1e-13
Identities = 66/232 (28%), Positives = 104/232 (44%), Gaps = 11/232 (4%)
Query: 81 VQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAF 140
V++L+ N+ D TPLH AA G LQ++L SG + + D P+H AA
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 141 HGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDN 200
L LL+ + D P+H+AA C + L +SS L + +
Sbjct: 84 SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS----LNVADRS 139
Query: 201 GENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVED 258
G + L A + + +GA D ++++ P H AAF G L +LK LV
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ----PLHWAAFLGHLEVLKLLVAR 195
Query: 259 GVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
G ++ + G +H AA G IE +++L++MGA+ + N G +A
Sbjct: 196 GA-DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Score = 32.7 bits (73), Expect = 0.57
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 70 HIAAIRGQDACVQALIMNGANLTAQDDRGCTP 101
HIAA G + VQAL+ +GA + A D+ G TP
Sbjct: 966 HIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (284), Expect = 2e-25
Identities = 86/289 (29%), Positives = 129/289 (44%), Gaps = 50/289 (17%)
Query: 20 CSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDA 79
C KK + +H A +G + + +LL G D+ G T H+A GQD
Sbjct: 201 CKDKK-SYTPLHAAASSGMISVVK------YLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253
Query: 80 CVQALIMNGANLTAQDDRGCTPLHLAA--THGHSFTLQIMLRSGVDPSVTDKREWRPVHY 137
V LI GA + ++++G TPLH AA THG + L++++ +G D ++ K P+H
Sbjct: 254 VVNELIDCGAIVNQKNEKGFTPLHFAAASTHG-ALCLELLVGNGADVNMKSKDGKTPLHM 312
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAF 197
A HGR Q +++ G I+ D NGN P+H+AA GH L++
Sbjct: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT------------ 360
Query: 198 NDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVE 257
GA+ + + FP H+AA G +KL+
Sbjct: 361 -----------------------SGADTAKRGIHGM----FPLHLAALSGFSDCCRKLLS 393
Query: 258 DGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP 306
G +I+ D G T +H AA G++ECL L+ GAD N +K G P
Sbjct: 394 SG-FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Score = 105 bits (262), Expect = 7e-23
Identities = 86/318 (27%), Positives = 142/318 (44%), Gaps = 43/318 (13%)
Query: 46 VCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLA 105
+CL L+ +GAD+ + G T H+ A+ G+ + Q +I +GA + +D G TPLH+A
Sbjct: 287 LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIA 346
Query: 106 ATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGN 165
A +GH + ++ SG D + P+H AA G C + L+ G I+ D G
Sbjct: 347 ARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR 406
Query: 166 LPVHLAAMEGHLHCFKFLVSRMSSAT-------------------QVLKAFNDNGENVLD 206
+H AA G+L C L++ + Q L A +G +V D
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND 466
Query: 207 LAQRFFKQNILQFIQGAEYEGKDLE------------DQETLAFPGHVAAFKGDLGM--- 251
L +R L + ++ +GK LE D++ + AA+ L +
Sbjct: 467 LDERGCTP--LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Query: 252 -----LKKLVEDGVININERADNGST--PMHKAAGQGHIECLQWLIKMGADSNITNKAGE 304
L L+E ++ +DN +T P+H AA GH + L+ L++ D ++ N +G
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
Query: 305 RPSDVAKRFAHLAAVKLL 322
P D+A H+ V +L
Sbjct: 585 TPLDLAAFKGHVECVDVL 602
Score = 99.8 bits (247), Expect = 4e-21
Identities = 76/267 (28%), Positives = 120/267 (44%), Gaps = 11/267 (4%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
L++ D+ T H AA G ++ LI++GA + A+D + TPLH A
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+Q++L+ D + DK P+H AA + + C + LV ++ D G +H
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGK 228
AA GH K L+SR ++ + AF+ + A +++ + GAE K
Sbjct: 147 AAFSGHGEMVKLLLSRGAN----INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
Query: 229 DLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
D + P H AA G + ++K L++ GV ++NE G+TP+H A G +
Sbjct: 203 DKKSYT----PLHAAASSGMISVVKYLLDLGV-DMNEPNAYGNTPLHVACYNGQDVVVNE 257
Query: 289 LIKMGADSNITNKAGERPSDVAKRFAH 315
LI GA N N+ G P A H
Sbjct: 258 LIDCGAIVNQKNEKGFTPLHFAAASTH 284
Score = 99.0 bits (245), Expect = 7e-21
Identities = 73/273 (26%), Positives = 121/273 (44%), Gaps = 8/273 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL H AD+ T HIAA C +AL+ +N+ D G T LH AA GH
Sbjct: 93 LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
++++L G + + DK++ R +H+AA+ G + ++LLV G + D P+H
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA G + K+L+ + N G L +A + ++ + G +
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEP----NAYGNTPLHVACYNGQDVVVNELIDC---GAIV 265
Query: 231 EDQETLAF-PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ F P H AA + +L+ ++N ++ +G TP+H A G Q +
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTI 325
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
I+ GA + +K G P +A R+ H + L
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Score = 96.3 bits (238), Expect = 4e-20
Identities = 80/303 (26%), Positives = 131/303 (43%), Gaps = 49/303 (16%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C++ LL GA++ G TA H A+ G + CV AL+ +GA +D RG TP+HL+A
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Query: 107 THGHSFTLQIMLRSG----VDPSVTDKREWRPVHYAAFHGRLGCLQLLVK---------- 152
GH L +L+S +P+ D + +H+A ++G C++LL++
Sbjct: 728 ACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN 787
Query: 153 -----------------------WGCSIED-VDYNGNLPVHLAAMEGHLHCFKFLVSRMS 188
G SI + D G P+H AA H+ C + L+S +
Sbjct: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
Query: 189 SATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGD 248
V + G+ L +A + N ++ + + L+D H+A KG
Sbjct: 848 QVNSV----DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNT-ALHLACSKGH 902
Query: 249 ----LGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGE 304
L +L+K+ + +IN A TP+H AA G +Q L+ GA ++ G
Sbjct: 903 ETSALLILEKITDRNLINATNAA--LQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
Query: 305 RPS 307
P+
Sbjct: 961 TPA 963
Score = 95.5 bits (236), Expect = 7e-20
Identities = 77/279 (27%), Positives = 133/279 (47%), Gaps = 16/279 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A GD +EI+ L L+ GA + ++ T H A + VQ L+ + A
Sbjct: 45 LHAAAYLGD----AEIIEL--LILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSA 98
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
++ A+D TPLH+AA + + ++ + +V+D+ +H+AAF G ++L
Sbjct: 99 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 158
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G +I D +H AA GH+ K LVS + T + L A
Sbjct: 159 LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT----CKDKKSYTPLHAAA 214
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLA-FPGHVAAFKGDLGMLKKLVEDGVININERAD 268
++++++ G D+ + P HVA + G ++ +L++ G I +N++ +
Sbjct: 215 SSGMISVVKYLLDL---GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI-VNQKNE 270
Query: 269 NGSTPMHKAAGQGH-IECLQWLIKMGADSNITNKAGERP 306
G TP+H AA H CL+ L+ GAD N+ +K G+ P
Sbjct: 271 KGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
Score = 93.6 bits (231), Expect = 3e-19
Identities = 82/307 (26%), Positives = 134/307 (43%), Gaps = 25/307 (8%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM----------NGANLTAQDD 96
CL +LL + A+ +G+ A H +A G C+Q + +G ++ + D
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
Query: 97 RGCT--PLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWG 154
T PLHLAA HGH L+++++S +D V + P+ AAF G + C+ +L+ G
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
Query: 155 CSIEDVDY-NGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFK 213
SI DY P+H AA GH C + L+ + + + NG+ L L+
Sbjct: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGH 665
Query: 214 QNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGS 271
+ + + +GA + KD + L H A G + L++ G R G
Sbjct: 666 TDCVYSLLNKGANVDAKDKWGRTAL----HRGAVTGHEECVDALLQHGA-KCLLRDSRGR 720
Query: 272 TPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFA----HLAAVKLLEELQK 327
TP+H +A GHI L L++ A + + A +A H V+LL E +
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 328 YDIDDEN 334
+ + N
Sbjct: 781 FQKTEGN 787
Score = 93.2 bits (230), Expect = 4e-19
Identities = 78/286 (27%), Positives = 122/286 (42%), Gaps = 14/286 (4%)
Query: 45 IVCLHWLLWHGADIT---HVTTRGWTASHIAAIRGQDACVQALIMNGANLTA---QDDRG 98
+ C+ L+ GA I ++ R T H AA G C++ LI N A QD G
Sbjct: 596 VECVDVLINQGASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 653
Query: 99 CTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIE 158
TPL L+ +GH+ + +L G + DK +H A G C+ L++ G
Sbjct: 654 QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL 713
Query: 159 DVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQ 218
D G P+HL+A GH+ L+ +S +++G L A + ++
Sbjct: 714 LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE 773
Query: 219 FIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKLVED-GVININERADNGSTPMHK 276
+ E + + E AF P H A + G + L++ G +N G TP+H
Sbjct: 774 LL----LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829
Query: 277 AAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
AA H+ECLQ L+ A N + G+ P +A V++L
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 88.2 bits (217), Expect = 1e-17
Identities = 69/248 (27%), Positives = 110/248 (44%), Gaps = 25/248 (10%)
Query: 72 AAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE 131
A G V+ALI ++ QD+ TPLH AA G + +++++ SG + D +
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 132 WRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSAT 191
P+H A +Q+L+K + D N P+H+AA + C + LV +S+
Sbjct: 75 LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
Query: 192 QVLK---------AFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHV 242
+ AF+ +GE V L R GA D +D+ + H
Sbjct: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSR-----------GANINAFDKKDRRAI----HW 179
Query: 243 AAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKA 302
AA+ G + ++K LV G + + TP+H AA G I +++L+ +G D N N
Sbjct: 180 AAYMGHIEVVKLLVSHGA-EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
Query: 303 GERPSDVA 310
G P VA
Sbjct: 239 GNTPLHVA 246
Score = 62.4 bits (150), Expect = 7e-10
Identities = 44/127 (34%), Positives = 64/127 (50%), Gaps = 4/127 (3%)
Query: 45 IVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMN-GANLTAQDDRGCTPLH 103
+ CL LL H A + V + G T +AA GQ V+ L+ + A LT QD+ T LH
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Query: 104 LAATHGHSFTLQIMLRSGVDPSV---TDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDV 160
LA + GH + ++L D ++ T+ P+H AA +G +Q L+ G S+ V
Sbjct: 896 LACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAV 955
Query: 161 DYNGNLP 167
D NG P
Sbjct: 956 DENGYTP 962
Score = 45.8 bits (107), Expect = 7e-05
Identities = 51/201 (25%), Positives = 78/201 (38%), Gaps = 42/201 (20%)
Query: 123 DPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKF 182
D + D + P+H AA+ G ++LL+ G + D P+H A
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRA----------- 81
Query: 183 LVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHV 242
+ S A QVL + A+ +D Q L H+
Sbjct: 82 VASCSEEAVQVLLKHS------------------------ADVNARDKNWQTPL----HI 113
Query: 243 AAFKGDLGMLKKLVED-GVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNK 301
AA + + LV +N+++RA G T +H AA GH E ++ L+ GA+ N +K
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRA--GRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171
Query: 302 AGERPSDVAKRFAHLAAVKLL 322
R A H+ VKLL
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLL 192
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 112 bits (280), Expect = 6e-25
Identities = 83/276 (30%), Positives = 128/276 (46%), Gaps = 12/276 (4%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL HGAD V GW H AA G D + L+ +GA + AQ+ G TPLHLAA +
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
++++ DP++ + P+H AA+ G + ++LL G ++ N P+HL
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGK 228
A G + + L+ + V A + +G L A K I + + GA E
Sbjct: 534 AVERGKVRAIQHLL----KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
Query: 229 DLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
+ P H+AA+KG L ++ L E N+ TP+H AA G +
Sbjct: 590 THQGWT----PLHLAAYKGHLEIIHLLAESHA-NMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 289 LIKMGADSNITNKAGERPSDVA-KRFAHLAAVKLLE 323
L++ GAD N ++G P +A +R L+ + LLE
Sbjct: 645 LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLE 680
Score = 93.6 bits (231), Expect = 3e-19
Identities = 69/260 (26%), Positives = 119/260 (45%), Gaps = 11/260 (4%)
Query: 67 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
T H +G V+ L+ + ++ Q G TPL +AA ++L G D +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 127 TDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 186
D+ W P+H+AA +G G +LL+ G ++ + G P+HLAA + + LVSR
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 187 MSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAA 244
+ G+ L +A F ++++ + QGAE + + Q L P H+A
Sbjct: 484 QADP----NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ----QRNLRTPLHLAV 535
Query: 245 FKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGE 304
+G + ++ L++ G + + +G P+H AA +G + L++ GA + G
Sbjct: 536 ERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 305 RPSDVAKRFAHLAAVKLLEE 324
P +A HL + LL E
Sbjct: 595 TPLHLAAYKGHLEIIHLLAE 614
Score = 93.2 bits (230), Expect = 4e-19
Identities = 86/295 (29%), Positives = 124/295 (42%), Gaps = 17/295 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H V G V+Q+ LL H D+ T G+T IAA Q L+ +GA
Sbjct: 366 LHFLVAQGSVEQV------RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ D+ G PLH AA +G T +++L G ++ W P+H AA + +L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
LV + G P+H+AA GH+ K L S+ + L A N L LA
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE----LDAQQRNLRTPLHLAV 535
Query: 210 RFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERA 267
K +Q + GA D DQ P H AA +G + K L+ G ++
Sbjct: 536 ERGKVRAIQHLLKSGAV---PDALDQSGYG-PLHTAAARGKYLICKMLLRYGA-SLELPT 590
Query: 268 DNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H AA +GH+E + L + A+ P +A R A V L
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 86.3 bits (212), Expect = 4e-17
Identities = 75/274 (27%), Positives = 115/274 (41%), Gaps = 40/274 (14%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+AA G + V+ L GA L AQ TPLHLA G +Q +L+SG P
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL- 183
D+ + P+H AA G+ ++L+++G S+E + G P+HLAA +GHL L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 184 ----------------------------VSRMSSATQVLKAFNDNGENVLDLAQRFFKQN 215
VS + A +G L LA + +
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ--RST 671
Query: 216 ILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMH 275
L I E+ + P H+AA KG+ +LK LVE G ++ + TP+
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA-QLDVQDGVSCTPLQ 730
Query: 276 ---KAAGQGHIECLQWLIKMGADSNITNKAGERP 306
++ QG + L+ G + ++ G +P
Sbjct: 731 LALRSRKQGIMSFLE-----GKEPSVATLGGSKP 759
Score = 72.0 bits (175), Expect = 9e-13
Identities = 61/224 (27%), Positives = 94/224 (41%), Gaps = 35/224 (15%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H AV G V+ + LL GA + G+ H AA RG+ + L+ GA
Sbjct: 531 LHLAVERGKVRAIQH------LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+L +G TPLHLAA GH + ++ S + W P+H AA HG +
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 150 LVKWGCSIEDVDYNGNLPVHLAA-----------MEGH--LHCFKFL------VSRMSSA 190
L++ G + +G P+HLA +E H +H + ++ +
Sbjct: 645 LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN 704
Query: 191 TQVLKAFNDNGENV----------LDLAQRFFKQNILQFIQGAE 224
T +LK + G + L LA R KQ I+ F++G E
Sbjct: 705 TAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
Score = 66.2 bits (160), Expect = 5e-11
Identities = 42/142 (29%), Positives = 64/142 (45%)
Query: 48 LHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAAT 107
+H L A++ + WT H+AA G++A V AL+ GA+ A + G TPLHLA
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668
Query: 108 HGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP 167
++ +L + +K W P H AA G L++LV+ G ++ D P
Sbjct: 669 RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728
Query: 168 VHLAAMEGHLHCFKFLVSRMSS 189
+ LA FL + S
Sbjct: 729 LQLALRSRKQGIMSFLEGKEPS 750
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 111 bits (278), Expect = 1e-24
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 9/275 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + G T HIA+ RG V+ L+ GA + + TPLH AA +GH
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+I+L G K P+H AA L C++LL+++ I+D+ + P+H+
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA GH K L+ + A +A NG L +A K+N ++ ++ G +
Sbjct: 378 AAHCGHHRVAKVLLDK--GAKPNSRAL--NGFTPLHIA---CKKNHVRVMELLLKTGASI 430
Query: 231 ED-QETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ E+ P HVA+F G L ++K L++ G + N TP+H AA GH E ++L
Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ A N K + P A R H VKLL E
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Score = 105 bits (262), Expect = 7e-23
Identities = 81/308 (26%), Positives = 142/308 (46%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +H A R G V+ + LL A +T +G+T H+AA G
Sbjct: 527 ANPNLATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYG 580
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ + L+ A+ A G TPLH+A H + ++++L G P + P+H
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ + L+++G S G P+HLAA EGH L+S+ ++
Sbjct: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN----L 696
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
N +G L L + + + G ++ + + P HVA+ G++ ++K L
Sbjct: 697 GNKSGLTPLHLVAQ---EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ ++N + G +P+H+AA QGH + + L+K GA N + G P +AKR +
Sbjct: 754 LQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
Query: 316 LAAVKLLE 323
++ +L+
Sbjct: 813 ISVTDVLK 820
Score = 103 bits (258), Expect = 2e-22
Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G + LL + A+ TT G T HIAA G V AL+ A
Sbjct: 507 LHCAARIGHTNMVK------LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ +G TPLH+AA +G +++L P+ K P+H A H L ++L
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 620
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G S +NG P+H+AA + + + L+ SA A + G L LA
Sbjct: 621 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA----NAESVQGVTPLHLAA 676
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
+ ++ + + G +L ++ L P H+ A +G + + L++ GV+ ++
Sbjct: 677 QEGHAEMVALLLSKQANG-NLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVM-VDATTRM 733
Query: 270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H A+ G+I+ +++L++ AD N K G P A + H V LL
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 100 bits (249), Expect = 2e-21
Identities = 89/319 (27%), Positives = 150/319 (47%), Gaps = 28/319 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRG 76
N C++ ++ +H A + G VK + E++ H I TT+ G TA HIAA+ G
Sbjct: 72 NTCNQNGLN--GLHLASKEGHVKMVVELL-------HKEIILETTTKKGNTALHIAALAG 122
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
QD V+ L+ GAN+ AQ +G TPL++AA H ++ +L +G + +V + + P+
Sbjct: 123 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLK 195
A G + L+ +G LP +H+AA L+ + + K
Sbjct: 183 VALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 196 AFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK 253
G L +A + N+ Q + +GA + Q + P H+A+ +G++ M++
Sbjct: 238 ----TGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGIT-PLHIASRRGNVIMVR 289
Query: 254 KLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRF 313
L++ G I + + TP+H AA GH+ + L+ GA K G P +A +
Sbjct: 290 LLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348
Query: 314 AHLAAVKLLEELQKYDIDD 332
HL V+LL + +IDD
Sbjct: 349 DHLDCVRLLLQYDA-EIDD 366
Score = 99.4 bits (246), Expect = 5e-21
Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 15/298 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A RAG + +LL + A + T H AA G V+ L+ N A
Sbjct: 474 LHMAARAGHTEVAK------YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N G TPLH+AA GH T+ +L + K+ + P+H AA +G++ +L
Sbjct: 528 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 587
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ NG P+H+A +L K L+ R S NG L +A
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAA 643
Query: 210 RFFKQNILQFIQG-AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
KQN ++ + +Y G + P H+AA +G M+ L+ N N
Sbjct: 644 ---KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNK 699
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQ 326
+G TP+H A +GH+ LIK G + T + G P VA + ++ VK L + Q
Sbjct: 700 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757
Score = 97.1 bits (240), Expect = 2e-20
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + A+I +T T H+AA G + L+ GA ++ G TPLH+A
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 412
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
H ++++L++G + P+H A+F G L ++ L++ G S +
Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
P+H+AA GH K+L+ A+
Sbjct: 473 PLHMAARAGHTEVAKYLLQNK-----------------------------------AKVN 497
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
K +DQ P H AA G M+K L+E+ N N G TP+H AA +GH+E +
Sbjct: 498 AKAKDDQT----PLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETV 552
Query: 287 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
L++ A K G P VA ++ + +LL E
Sbjct: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/239 (26%), Positives = 109/239 (45%), Gaps = 13/239 (5%)
Query: 85 IMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
+ NG ++ + G LHLA+ GH + +L + T K+ +H AA G+
Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204
++ LV +G ++ G P+++AA E HL KFL+ + A Q ++G
Sbjct: 125 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE--NGANQ--NVATEDGFTP 180
Query: 205 LDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVINI 263
L +A + +N++ + +GK + P H+AA D L+++ N
Sbjct: 181 LAVALQQGHENVVAHLINYGTKGK-------VRLPALHIAARNDDTRTAAVLLQNDP-NP 232
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ + G TP+H AA ++ Q L+ GA N T + G P +A R ++ V+LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Score = 65.5 bits (158), Expect = 8e-11
Identities = 47/165 (28%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+ A G LI +G + A G TPLH+A+ +G+ ++ +L+ D
Sbjct: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K + P+H AA G + LL+K G S +V +G P+ +A G++
Sbjct: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI------- 813
Query: 185 SRMSSATQVLKAFNDNGENVL--DLAQRFFKQNILQFIQGAEYEG 227
S T VLK D VL D + F + + + + +E EG
Sbjct: 814 ----SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG 854
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 111 bits (278), Expect = 1e-24
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 9/275 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + G T HIA+ RG V+ L+ GA + + TPLH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+I+L G K P+H AA L C++LL+++ I+D+ + P+H+
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA GH K L+ + A +A NG L +A K+N ++ ++ G +
Sbjct: 345 AAHCGHHRVAKVLLDK--GAKPNSRAL--NGFTPLHIA---CKKNHVRVMELLLKTGASI 397
Query: 231 ED-QETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ E+ P HVA+F G L ++K L++ G + N TP+H AA GH E ++L
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ A N K + P A R H VKLL E
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 105 bits (262), Expect = 7e-23
Identities = 81/308 (26%), Positives = 142/308 (46%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +H A R G V+ + LL A +T +G+T H+AA G
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ + L+ A+ A G TPLH+A H + ++++L G P + P+H
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ + L+++G S G P+HLAA EGH L+S+ ++
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN----L 663
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
N +G L L + + + G ++ + + P HVA+ G++ ++K L
Sbjct: 664 GNKSGLTPLHLVAQ---EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ ++N + G +P+H+AA QGH + + L+K GA N + G P +AKR +
Sbjct: 721 LQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 316 LAAVKLLE 323
++ +L+
Sbjct: 780 ISVTDVLK 787
Score = 103 bits (258), Expect = 2e-22
Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G + LL + A+ TT G T HIAA G V AL+ A
Sbjct: 474 LHCAARIGHTNMVK------LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ +G TPLH+AA +G +++L P+ K P+H A H L ++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G S +NG P+H+AA + + + L+ SA A + G L LA
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA----NAESVQGVTPLHLAA 643
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
+ ++ + + G +L ++ L P H+ A +G + + L++ GV+ ++
Sbjct: 644 QEGHAEMVALLLSKQANG-NLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVM-VDATTRM 700
Query: 270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H A+ G+I+ +++L++ AD N K G P A + H V LL
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 100 bits (249), Expect = 2e-21
Identities = 89/319 (27%), Positives = 150/319 (47%), Gaps = 28/319 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRG 76
N C++ ++ +H A + G VK + E++ H I TT+ G TA HIAA+ G
Sbjct: 39 NTCNQNGLN--GLHLASKEGHVKMVVELL-------HKEIILETTTKKGNTALHIAALAG 89
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
QD V+ L+ GAN+ AQ +G TPL++AA H ++ +L +G + +V + + P+
Sbjct: 90 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLK 195
A G + L+ +G LP +H+AA L+ + + K
Sbjct: 150 VALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 196 AFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK 253
G L +A + N+ Q + +GA + Q + P H+A+ +G++ M++
Sbjct: 205 ----TGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGIT-PLHIASRRGNVIMVR 256
Query: 254 KLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRF 313
L++ G I + + TP+H AA GH+ + L+ GA K G P +A +
Sbjct: 257 LLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 314 AHLAAVKLLEELQKYDIDD 332
HL V+LL + +IDD
Sbjct: 316 DHLDCVRLLLQYDA-EIDD 333
Score = 99.4 bits (246), Expect = 5e-21
Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 15/298 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A RAG + +LL + A + T H AA G V+ L+ N A
Sbjct: 441 LHMAARAGHTEVAK------YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N G TPLH+AA GH T+ +L + K+ + P+H AA +G++ +L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ NG P+H+A +L K L+ R S NG L +A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAA 610
Query: 210 RFFKQNILQFIQG-AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
KQN ++ + +Y G + P H+AA +G M+ L+ N N
Sbjct: 611 ---KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNK 666
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQ 326
+G TP+H A +GH+ LIK G + T + G P VA + ++ VK L + Q
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 97.1 bits (240), Expect = 2e-20
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + A+I +T T H+AA G + L+ GA ++ G TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
H ++++L++G + P+H A+F G L ++ L++ G S +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
P+H+AA GH K+L+ A+
Sbjct: 440 PLHMAARAGHTEVAKYLLQNK-----------------------------------AKVN 464
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
K +DQ P H AA G M+K L+E+ N N G TP+H AA +GH+E +
Sbjct: 465 AKAKDDQT----PLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETV 519
Query: 287 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
L++ A K G P VA ++ + +LL E
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/239 (26%), Positives = 109/239 (45%), Gaps = 13/239 (5%)
Query: 85 IMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
+ NG ++ + G LHLA+ GH + +L + T K+ +H AA G+
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204
++ LV +G ++ G P+++AA E HL KFL+ + A Q ++G
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE--NGANQ--NVATEDGFTP 147
Query: 205 LDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVINI 263
L +A + +N++ + +GK + P H+AA D L+++ N
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGK-------VRLPALHIAARNDDTRTAAVLLQNDP-NP 199
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ + G TP+H AA ++ Q L+ GA N T + G P +A R ++ V+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 13/168 (7%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+ A G LI +G + A G TPLH+A+ +G+ ++ +L+ D
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K + P+H AA G + LL+K G S +V +G P+ +A G++
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI------- 780
Query: 185 SRMSSATQVLKAFNDNGENVL--DLAQRFFKQNILQFIQGAEYEGKDL 230
S T VLK D VL D + F + + + + +E EG++L
Sbjct: 781 ----SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEEL 824
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 111 bits (278), Expect = 1e-24
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 9/275 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + G T HIA+ RG V+ L+ GA + + TPLH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+I+L G K P+H AA L C++LL+++ I+D+ + P+H+
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA GH K L+ + A +A NG L +A K+N ++ ++ G +
Sbjct: 345 AAHCGHHRVAKVLLDK--GAKPNSRAL--NGFTPLHIA---CKKNHVRVMELLLKTGASI 397
Query: 231 ED-QETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ E+ P HVA+F G L ++K L++ G + N TP+H AA GH E ++L
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ A N K + P A R H VKLL E
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 105 bits (262), Expect = 7e-23
Identities = 81/308 (26%), Positives = 142/308 (46%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +H A R G V+ + LL A +T +G+T H+AA G
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ + L+ A+ A G TPLH+A H + ++++L G P + P+H
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ + L+++G S G P+HLAA EGH L+S+ ++
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN----L 663
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
N +G L L + + + G ++ + + P HVA+ G++ ++K L
Sbjct: 664 GNKSGLTPLHLVAQ---EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ ++N + G +P+H+AA QGH + + L+K GA N + G P +AKR +
Sbjct: 721 LQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 316 LAAVKLLE 323
++ +L+
Sbjct: 780 ISVTDVLK 787
Score = 103 bits (258), Expect = 2e-22
Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G + LL + A+ TT G T HIAA G V AL+ A
Sbjct: 474 LHCAARIGHTNMVK------LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ +G TPLH+AA +G +++L P+ K P+H A H L ++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G S +NG P+H+AA + + + L+ SA A + G L LA
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA----NAESVQGVTPLHLAA 643
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
+ ++ + + G +L ++ L P H+ A +G + + L++ GV+ ++
Sbjct: 644 QEGHAEMVALLLSKQANG-NLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVM-VDATTRM 700
Query: 270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H A+ G+I+ +++L++ AD N K G P A + H V LL
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 100 bits (249), Expect = 2e-21
Identities = 89/319 (27%), Positives = 150/319 (47%), Gaps = 28/319 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRG 76
N C++ ++ +H A + G VK + E++ H I TT+ G TA HIAA+ G
Sbjct: 39 NTCNQNGLN--GLHLASKEGHVKMVVELL-------HKEIILETTTKKGNTALHIAALAG 89
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
QD V+ L+ GAN+ AQ +G TPL++AA H ++ +L +G + +V + + P+
Sbjct: 90 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLK 195
A G + L+ +G LP +H+AA L+ + + K
Sbjct: 150 VALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 196 AFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK 253
G L +A + N+ Q + +GA + Q + P H+A+ +G++ M++
Sbjct: 205 ----TGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGIT-PLHIASRRGNVIMVR 256
Query: 254 KLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRF 313
L++ G I + + TP+H AA GH+ + L+ GA K G P +A +
Sbjct: 257 LLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 314 AHLAAVKLLEELQKYDIDD 332
HL V+LL + +IDD
Sbjct: 316 DHLDCVRLLLQYDA-EIDD 333
Score = 99.4 bits (246), Expect = 5e-21
Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 15/298 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A RAG + +LL + A + T H AA G V+ L+ N A
Sbjct: 441 LHMAARAGHTEVAK------YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N G TPLH+AA GH T+ +L + K+ + P+H AA +G++ +L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ NG P+H+A +L K L+ R S NG L +A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAA 610
Query: 210 RFFKQNILQFIQG-AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
KQN ++ + +Y G + P H+AA +G M+ L+ N N
Sbjct: 611 ---KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNK 666
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQ 326
+G TP+H A +GH+ LIK G + T + G P VA + ++ VK L + Q
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 97.1 bits (240), Expect = 2e-20
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + A+I +T T H+AA G + L+ GA ++ G TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
H ++++L++G + P+H A+F G L ++ L++ G S +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
P+H+AA GH K+L+ A+
Sbjct: 440 PLHMAARAGHTEVAKYLLQNK-----------------------------------AKVN 464
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
K +DQ P H AA G M+K L+E+ N N G TP+H AA +GH+E +
Sbjct: 465 AKAKDDQT----PLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETV 519
Query: 287 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
L++ A K G P VA ++ + +LL E
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/239 (26%), Positives = 109/239 (45%), Gaps = 13/239 (5%)
Query: 85 IMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
+ NG ++ + G LHLA+ GH + +L + T K+ +H AA G+
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204
++ LV +G ++ G P+++AA E HL KFL+ + A Q ++G
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE--NGANQ--NVATEDGFTP 147
Query: 205 LDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVINI 263
L +A + +N++ + +GK + P H+AA D L+++ N
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGK-------VRLPALHIAARNDDTRTAAVLLQNDP-NP 199
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ + G TP+H AA ++ Q L+ GA N T + G P +A R ++ V+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 13/168 (7%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+ A G LI +G + A G TPLH+A+ +G+ ++ +L+ D
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K + P+H AA G + LL+K G S +V +G P+ +A G++
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI------- 780
Query: 185 SRMSSATQVLKAFNDNGENVL--DLAQRFFKQNILQFIQGAEYEGKDL 230
S T VLK D VL D + F + + + + +E EG++L
Sbjct: 781 ----SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEEL 824
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 111 bits (278), Expect = 1e-24
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 9/275 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + G T HIA+ RG V+ L+ GA + + TPLH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+I+L G K P+H AA L C++LL+++ I+D+ + P+H+
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA GH K L+ + A +A NG L +A K+N ++ ++ G +
Sbjct: 345 AAHCGHHRVAKVLLDK--GAKPNSRAL--NGFTPLHIA---CKKNHVRVMELLLKTGASI 397
Query: 231 ED-QETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ E+ P HVA+F G L ++K L++ G + N TP+H AA GH E ++L
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ A N K + P A R H VKLL E
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 105 bits (262), Expect = 7e-23
Identities = 81/308 (26%), Positives = 142/308 (46%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +H A R G V+ + LL A +T +G+T H+AA G
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ + L+ A+ A G TPLH+A H + ++++L G P + P+H
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ + L+++G S G P+HLAA EGH L+S+ ++
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN----L 663
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
N +G L L + + + G ++ + + P HVA+ G++ ++K L
Sbjct: 664 GNKSGLTPLHLVAQ---EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ ++N + G +P+H+AA QGH + + L+K GA N + G P +AKR +
Sbjct: 721 LQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 316 LAAVKLLE 323
++ +L+
Sbjct: 780 ISVTDVLK 787
Score = 103 bits (258), Expect = 2e-22
Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G + LL + A+ TT G T HIAA G V AL+ A
Sbjct: 474 LHCAARIGHTNMVK------LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ +G TPLH+AA +G +++L P+ K P+H A H L ++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G S +NG P+H+AA + + + L+ SA A + G L LA
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA----NAESVQGVTPLHLAA 643
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
+ ++ + + G +L ++ L P H+ A +G + + L++ GV+ ++
Sbjct: 644 QEGHAEMVALLLSKQANG-NLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVM-VDATTRM 700
Query: 270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H A+ G+I+ +++L++ AD N K G P A + H V LL
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 100 bits (249), Expect = 2e-21
Identities = 89/319 (27%), Positives = 150/319 (47%), Gaps = 28/319 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRG 76
N C++ ++ +H A + G VK + E++ H I TT+ G TA HIAA+ G
Sbjct: 39 NTCNQNGLN--GLHLASKEGHVKMVVELL-------HKEIILETTTKKGNTALHIAALAG 89
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
QD V+ L+ GAN+ AQ +G TPL++AA H ++ +L +G + +V + + P+
Sbjct: 90 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLK 195
A G + L+ +G LP +H+AA L+ + + K
Sbjct: 150 VALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 196 AFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK 253
G L +A + N+ Q + +GA + Q + P H+A+ +G++ M++
Sbjct: 205 ----TGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGIT-PLHIASRRGNVIMVR 256
Query: 254 KLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRF 313
L++ G I + + TP+H AA GH+ + L+ GA K G P +A +
Sbjct: 257 LLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 314 AHLAAVKLLEELQKYDIDD 332
HL V+LL + +IDD
Sbjct: 316 DHLDCVRLLLQYDA-EIDD 333
Score = 99.4 bits (246), Expect = 5e-21
Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 15/298 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A RAG + +LL + A + T H AA G V+ L+ N A
Sbjct: 441 LHMAARAGHTEVAK------YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N G TPLH+AA GH T+ +L + K+ + P+H AA +G++ +L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ NG P+H+A +L K L+ R S NG L +A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAA 610
Query: 210 RFFKQNILQFIQG-AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
KQN ++ + +Y G + P H+AA +G M+ L+ N N
Sbjct: 611 ---KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNK 666
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQ 326
+G TP+H A +GH+ LIK G + T + G P VA + ++ VK L + Q
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 97.1 bits (240), Expect = 2e-20
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + A+I +T T H+AA G + L+ GA ++ G TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
H ++++L++G + P+H A+F G L ++ L++ G S +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
P+H+AA GH K+L+ A+
Sbjct: 440 PLHMAARAGHTEVAKYLLQNK-----------------------------------AKVN 464
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
K +DQ P H AA G M+K L+E+ N N G TP+H AA +GH+E +
Sbjct: 465 AKAKDDQT----PLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETV 519
Query: 287 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
L++ A K G P VA ++ + +LL E
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/239 (26%), Positives = 109/239 (45%), Gaps = 13/239 (5%)
Query: 85 IMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
+ NG ++ + G LHLA+ GH + +L + T K+ +H AA G+
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204
++ LV +G ++ G P+++AA E HL KFL+ + A Q ++G
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE--NGANQ--NVATEDGFTP 147
Query: 205 LDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVINI 263
L +A + +N++ + +GK + P H+AA D L+++ N
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGK-------VRLPALHIAARNDDTRTAAVLLQNDP-NP 199
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ + G TP+H AA ++ Q L+ GA N T + G P +A R ++ V+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 13/168 (7%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+ A G LI +G + A G TPLH+A+ +G+ ++ +L+ D
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K + P+H AA G + LL+K G S +V +G P+ +A G++
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI------- 780
Query: 185 SRMSSATQVLKAFNDNGENVL--DLAQRFFKQNILQFIQGAEYEGKDL 230
S T VLK D VL D + F + + + + +E EG++L
Sbjct: 781 ----SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEEL 824
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 111 bits (278), Expect = 1e-24
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 9/275 (3%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + G T HIA+ RG V+ L+ GA + + TPLH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
+I+L G K P+H AA L C++LL+++ I+D+ + P+H+
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDL 230
AA GH K L+ + A +A NG L +A K+N ++ ++ G +
Sbjct: 345 AAHCGHHRVAKVLLDK--GAKPNSRAL--NGFTPLHIA---CKKNHVRVMELLLKTGASI 397
Query: 231 ED-QETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWL 289
+ E+ P HVA+F G L ++K L++ G + N TP+H AA GH E ++L
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 290 IKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ A N K + P A R H VKLL E
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 105 bits (262), Expect = 7e-23
Identities = 81/308 (26%), Positives = 142/308 (46%), Gaps = 15/308 (4%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP +H A R G V+ + LL A +T +G+T H+AA G
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLA------LLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
+ + L+ A+ A G TPLH+A H + ++++L G P + P+H
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKA 196
AA ++ + L+++G S G P+HLAA EGH L+S+ ++
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN----L 663
Query: 197 FNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAF-PGHVAAFKGDLGMLKKL 255
N +G L L + + + G ++ + + P HVA+ G++ ++K L
Sbjct: 664 GNKSGLTPLHLVAQ---EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
++ ++N + G +P+H+AA QGH + + L+K GA N + G P +AKR +
Sbjct: 721 LQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 316 LAAVKLLE 323
++ +L+
Sbjct: 780 ISVTDVLK 787
Score = 103 bits (258), Expect = 2e-22
Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A R G + LL + A+ TT G T HIAA G V AL+ A
Sbjct: 474 LHCAARIGHTNMVK------LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
+ +G TPLH+AA +G +++L P+ K P+H A H L ++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L+ G S +NG P+H+AA + + + L+ SA A + G L LA
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA----NAESVQGVTPLHLAA 643
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADN 269
+ ++ + + G +L ++ L P H+ A +G + + L++ GV+ ++
Sbjct: 644 QEGHAEMVALLLSKQANG-NLGNKSGLT-PLHLVAQEGHVPVADVLIKHGVM-VDATTRM 700
Query: 270 GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
G TP+H A+ G+I+ +++L++ AD N K G P A + H V LL
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 100 bits (249), Expect = 2e-21
Identities = 89/319 (27%), Positives = 150/319 (47%), Gaps = 28/319 (8%)
Query: 18 NPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRG 76
N C++ ++ +H A + G VK + E++ H I TT+ G TA HIAA+ G
Sbjct: 39 NTCNQNGLN--GLHLASKEGHVKMVVELL-------HKEIILETTTKKGNTALHIAALAG 89
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVH 136
QD V+ L+ GAN+ AQ +G TPL++AA H ++ +L +G + +V + + P+
Sbjct: 90 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 137 YAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP-VHLAAMEGHLHCFKFLVSRMSSATQVLK 195
A G + L+ +G LP +H+AA L+ + + K
Sbjct: 150 VALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 196 AFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK 253
G L +A + N+ Q + +GA + Q + P H+A+ +G++ M++
Sbjct: 205 ----TGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGIT-PLHIASRRGNVIMVR 256
Query: 254 KLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRF 313
L++ G I + + TP+H AA GH+ + L+ GA K G P +A +
Sbjct: 257 LLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 314 AHLAAVKLLEELQKYDIDD 332
HL V+LL + +IDD
Sbjct: 316 DHLDCVRLLLQYDA-EIDD 333
Score = 99.4 bits (246), Expect = 5e-21
Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 15/298 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A RAG + +LL + A + T H AA G V+ L+ N A
Sbjct: 441 LHMAARAGHTEVAK------YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N G TPLH+AA GH T+ +L + K+ + P+H AA +G++ +L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ NG P+H+A +L K L+ R S NG L +A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAA 610
Query: 210 RFFKQNILQFIQG-AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
KQN ++ + +Y G + P H+AA +G M+ L+ N N
Sbjct: 611 ---KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNK 666
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQ 326
+G TP+H A +GH+ LIK G + T + G P VA + ++ VK L + Q
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 97.1 bits (240), Expect = 2e-20
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 47 CLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAA 106
C+ LL + A+I +T T H+AA G + L+ GA ++ G TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 107 THGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
H ++++L++G + P+H A+F G L ++ L++ G S +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 226
P+H+AA GH K+L+ A+
Sbjct: 440 PLHMAARAGHTEVAKYLLQNK-----------------------------------AKVN 464
Query: 227 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 286
K +DQ P H AA G M+K L+E+ N N G TP+H AA +GH+E +
Sbjct: 465 AKAKDDQT----PLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETV 519
Query: 287 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
L++ A K G P VA ++ + +LL E
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/239 (26%), Positives = 109/239 (45%), Gaps = 13/239 (5%)
Query: 85 IMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144
+ NG ++ + G LHLA+ GH + +L + T K+ +H AA G+
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
Query: 145 GCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204
++ LV +G ++ G P+++AA E HL KFL+ + A Q ++G
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE--NGANQ--NVATEDGFTP 147
Query: 205 LDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVINI 263
L +A + +N++ + +GK + P H+AA D L+++ N
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGK-------VRLPALHIAARNDDTRTAAVLLQNDP-NP 199
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ + G TP+H AA ++ Q L+ GA N T + G P +A R ++ V+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 13/168 (7%)
Query: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
G T H+ A G LI +G + A G TPLH+A+ +G+ ++ +L+ D
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 125 SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+ K + P+H AA G + LL+K G S +V +G P+ +A G++
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI------- 780
Query: 185 SRMSSATQVLKAFNDNGENVL--DLAQRFFKQNILQFIQGAEYEGKDL 230
S T VLK D VL D + F + + + + +E EG++L
Sbjct: 781 ----SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEEL 824
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 105 bits (262), Expect = 7e-23
Identities = 94/300 (31%), Positives = 141/300 (47%), Gaps = 13/300 (4%)
Query: 28 GSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMN 87
G +H A RAG + + +V L G H G T +H AA G A + L+
Sbjct: 38 GLVHHATRAGHLDCVKFLVQRAQL--PGNQRAH---NGATPAHDAAATGSLAELCWLVRE 92
Query: 88 GA-NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
G L QD G +PLHLAA GH ++ +L G ++ + RP+H+AA G L C
Sbjct: 93 GGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTC 152
Query: 147 LQLL-VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
L+LL G S+ +G P++LA EGHLH +FLV + A L+A +G + L
Sbjct: 153 LKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLV-KDCGADVHLRAL--DGMSAL 209
Query: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
A +++ ++ G D E A H AA G +L +L+ G +
Sbjct: 210 HAAAARGHYSLVVWLVTFTDIGLTARDNEG-ATALHFAARGGHTPILDRLLLMGTPIL-- 266
Query: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEEL 325
R G TP+H AA G +EC Q L+ D ++ ++ G +D+A+ H + L E+
Sbjct: 267 RDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV 326
Score = 71.2 bits (173), Expect = 1e-12
Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 104 LAATHGHSFTLQIMLRSG-VDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWG-CSIEDVD 161
+AA G TL+ +L +G + P +TD VH+A G L C++ LV+
Sbjct: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
Query: 162 YNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQ 221
+NG P H AA G L +LV Q A +G + L LA RF +++++
Sbjct: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA---SGVSPLHLAARFGHPVLVEWLL 124
Query: 222 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQG 281
E LE +E A P H AA GDL LK L ++N R +G++P++ A +G
Sbjct: 125 -HEGHSATLETREG-ARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEG 182
Query: 282 HIECLQWLIK-MGADSNITNKAGERPSDVAKRFAHLAAV 319
H+ Q+L+K GAD ++ G A H + V
Sbjct: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV 221
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 103 bits (256), Expect = 3e-22
Identities = 74/285 (25%), Positives = 126/285 (44%), Gaps = 43/285 (15%)
Query: 57 DITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQI 116
D+ + + T H+AA G ++ LI++GA + A+D+ TPLH A +Q+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 117 MLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGH 176
+++ D + DK P+H AA + + C ++++ S+ D G +H AA+ GH
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 177 LHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQE 234
+ L+++ ++ + AF+ L A +++ + GAE KD +
Sbjct: 128 VEMVNLLLAKGAN----INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
Query: 235 TLAFPGHVAAFKGDLGMLKKLVEDGV--------------------------------IN 262
P H AA G + ++K L+ GV N
Sbjct: 184 ----PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 263 INERADNGSTPMHKAAGQGH-IECLQWLIKMGADSNITNKAGERP 306
+N+ +NG TP+H AA H CL+ L+ GAD NI +K G+ P
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
Score = 94.0 bits (232), Expect = 2e-19
Identities = 68/256 (26%), Positives = 118/256 (46%), Gaps = 12/256 (4%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL A++ V G TA H + G + CVQ L+ ++ +D RG TPLH AA GH
Sbjct: 664 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Query: 111 SFTLQIMLR---SGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP 167
+ L +L+ S D D + + P+H+A ++G C+++L++ C + + N P
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTP 782
Query: 168 VHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEY 225
+H A + H +C L+ + S+ ++ +D G L A LQ + A
Sbjct: 783 LHCAIINDHGNCASLLLGAIDSS--IVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 226 EGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIEC 285
D + L +AA G G + LV ++ + + +TP+H A +GH +C
Sbjct: 841 NAVDNSGKTALM----MAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
Query: 286 LQWLIKMGADSNITNK 301
++ D ++ N+
Sbjct: 897 ALLILDKIQDESLINE 912
Score = 93.6 bits (231), Expect = 3e-19
Identities = 80/307 (26%), Positives = 120/307 (39%), Gaps = 68/307 (22%)
Query: 46 VCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLA 105
+CL L+ +GAD+ + G + H+ A+ G+ Q LI NG + D G TPLH+A
Sbjct: 262 LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321
Query: 106 ATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGN 165
A +GH + + SG D + P+H AA + C + L+ G I+ D G
Sbjct: 322 ARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGR 381
Query: 166 LPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEY 225
+H AA G++ C K L S GA++
Sbjct: 382 TCLHAAAAGGNVECIKLLQS-----------------------------------SGADF 406
Query: 226 EGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAA------- 278
KD + P H AA ++ LV G N+NE D G T +H AA
Sbjct: 407 HKKD----KCGRTPLHYAAANCHFHCIETLVTTGA-NVNETDDWGRTALHYAAASDMDRN 461
Query: 279 ----GQGHIE-----------------CLQWLIKMGADSNITNKAGERPSDVAKRFAHLA 317
G H CL++L++ A+ +I +K G A + H
Sbjct: 462 KTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQ 521
Query: 318 AVKLLEE 324
++LL E
Sbjct: 522 CLELLLE 528
Score = 92.8 bits (229), Expect = 5e-19
Identities = 86/350 (24%), Positives = 136/350 (38%), Gaps = 63/350 (18%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
L+ +G +I V G T H+AA G + + L +GA+ PLHLAA + H
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
S + +L SG + DK +H AA G + C++LL G D G P+H
Sbjct: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
Query: 171 AAMEGHLHCFKFLV----------------------SRMSSATQVLKAFNDNGE------ 202
AA H HC + LV S M +L +DN E
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479
Query: 203 -----------------------------NVLDLAQRFFKQNILQFIQGAEYEGKDLEDQ 233
N + A + + L+ + G + D
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
Query: 234 ETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMG 293
P H+AA+ G L+ L++ +++++ R + G T + AA +GH EC++ LI G
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQ-SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPG 598
Query: 294 ADSNITNKAGER-PSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVK 342
A + + +R P + H ++LL E+ D+ +D D K
Sbjct: 599 ASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI----ADNPEAVDVKDAK 644
Score = 90.9 bits (224), Expect = 2e-18
Identities = 85/329 (25%), Positives = 131/329 (39%), Gaps = 80/329 (24%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H A G+V+ C+ L GAD G T H AA C++ L+ GA
Sbjct: 384 LHAAAAGGNVE------CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
Query: 90 NLTAQDDRGCTPLHLAA-------------THGHS---------------FTLQIMLRSG 121
N+ DD G T LH AA H +S L+ +L++
Sbjct: 438 NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497
Query: 122 VDPSVTDKREWRPVHYAAFHGRLGCLQLLV-KWGCSIEDVDYNG-NLPVHLAAMEGHLHC 179
+PS+ DK + +HYAA +G CL+LL+ + E+ D P+HLAA GH
Sbjct: 498 ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557
Query: 180 FKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFP 239
+ L+ + L ++ G LDL
Sbjct: 558 LEVLLQSLVD----LDIRDEKGRTALDL-------------------------------- 581
Query: 240 GHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADS--- 296
AAFKG ++ L+ G + TP+H + GH CL+ L+++ AD+
Sbjct: 582 ---AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI-ADNPEA 637
Query: 297 -NITNKAGERPSDVAKRFAHLAAVKLLEE 324
++ + G+ P +A + H+ AV LL E
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLE 666
Score = 87.4 bits (215), Expect = 2e-17
Identities = 91/382 (23%), Positives = 153/382 (40%), Gaps = 73/382 (19%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVC------------------LHWLLWHG--- 55
ANP R K + SIH A G +Q E++ LH ++G
Sbjct: 498 ANPSIRDKEGYNSIHYAAAYGH-RQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQ 556
Query: 56 ---------ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDD-RGCTPLHLA 105
D+ +G TA +AA +G CV+ALI GA++ +D+ TPLH +
Sbjct: 557 ALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHAS 616
Query: 106 ATHGHSFTLQIMLRSGVDPSVTDKREWR---PVHYAAFHGRLGCLQLLVKWGCSIEDVDY 162
+GH+ L+++L +P D ++ + P+ A +G + + LL++ +++ VD
Sbjct: 617 VINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDI 676
Query: 163 NGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLD-LAQRFFKQNILQFIQ 221
G +H M GH C + L+ + S + + G L A R + + +Q
Sbjct: 677 LGCTALHRGIMTGHEECVQMLLEQEVS----ILCKDSRGRTPLHYAAARGHATWLSELLQ 732
Query: 222 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVED----------------GVIN--- 262
A E P H A + G+ ++ L+E +IN
Sbjct: 733 MALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHG 792
Query: 263 --------------INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSD 308
++ R D G TP+ AA H+ECLQ L++ A N + +G+
Sbjct: 793 NCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALM 852
Query: 309 VAKRFAHLAAVKLLEELQKYDI 330
+A AV +L + D+
Sbjct: 853 MAAENGQAGAVDILVNSAQADL 874
Score = 73.2 bits (178), Expect = 4e-13
Identities = 57/229 (24%), Positives = 99/229 (43%), Gaps = 11/229 (4%)
Query: 84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143
LI ++ D TPLH+AA G + +++++ SG + D P+H A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 144 LGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGEN 203
+Q+L+K + D N P+H+AA + C + ++ +SS + + G
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS----VNVSDRGGRT 117
Query: 204 VLDLA--QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVI 261
L A + L +GA D +D+ L H AA+ G L ++ L+ G
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRAL----HWAAYMGHLDVVALLINHGA- 172
Query: 262 NINERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
+ + G TP+H AA G I ++ L+ +G + + N G +A
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 45 IVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNG-ANLTAQDDRGCTPLH 103
+ CL LL H A + V G TA +AA GQ V L+ + A+LT +D TPLH
Sbjct: 827 VECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886
Query: 104 LAATHGHSFTLQIMLRSGVDPSVTDKR 130
LA + GH ++L D S+ +++
Sbjct: 887 LACSKGHEKCALLILDKIQDESLINEK 913
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 102 bits (254), Expect = 6e-22
Identities = 67/242 (27%), Positives = 128/242 (52%), Gaps = 12/242 (4%)
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N+ QD G + LH AA +G++ + ++L + + D + RP+HYAA+ GR ++L
Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
++K G ++ G++P+HLAA GH + L+ S+ V +++G+ LDLA
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMV----DNSGKTPLDLAC 156
Query: 210 RFFKQNILQFIQGAEYEGKDLEDQETLA------FPGHVAAFKGDLGMLKKLVEDGVINI 263
F + ++Q + + LE + A P H+AA G + +++ L++ G I+I
Sbjct: 157 EFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG-IDI 215
Query: 264 NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLE 323
N + +G T +H+AA G E ++ L+ G ++++ N + D+ +F A + ++
Sbjct: 216 NRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIK 274
Query: 324 EL 325
+L
Sbjct: 275 QL 276
Score = 70.5 bits (171), Expect = 2e-12
Identities = 48/166 (28%), Positives = 79/166 (47%), Gaps = 14/166 (8%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F ++H A G+ + +S LL A + +G H AA +G+ ++ ++
Sbjct: 50 FSALHHAALNGNTELIS------LLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLK 103
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
G+ + D G PLHLAA HGH +++L+ +P + D P+ A GR+G
Sbjct: 104 AGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGV 163
Query: 147 LQLLVKWG-CSI-------EDVDYNGNLPVHLAAMEGHLHCFKFLV 184
+QLL+ C+ + D NG P+HLAA GH+ + L+
Sbjct: 164 VQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
Score = 39.7 bits (91), Expect = 0.005
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Query: 241 HVAAFKGDLGMLKKLVE-DGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNIT 299
H AA G+ ++ L+E ++I + + G P+H AA QG E ++ ++K G+ NI
Sbjct: 54 HHAALNGNTELISLLLEAQAAVDIKD--NKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIP 111
Query: 300 NKAGERPSDVAKRFAHLAAVKLLEELQ 326
+ G P +A + H ++L + Q
Sbjct: 112 SDEGHIPLHLAAQHGHYDVSEMLLQHQ 138
Score = 31.2 bits (69), Expect = 1.7
Identities = 18/57 (31%), Positives = 29/57 (50%)
Query: 250 GMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP 306
G K L IN+N + +G + +H AA G+ E + L++ A +I + G RP
Sbjct: 29 GKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRP 85
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 100 bits (250), Expect = 2e-21
Identities = 73/243 (30%), Positives = 119/243 (48%), Gaps = 14/243 (5%)
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N+ QD G + LH AA G + ++L + + D RP+HYAA+ GRL ++L
Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
Query: 150 LVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQ 209
L++ ++ +G +P+HLAA GH + L+ S+ V KA + LDLA
Sbjct: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKA----KKTPLDLAC 156
Query: 210 RFFKQNILQFIQGA-------EYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVIN 262
F + + Q + + E E KD D P H+AA G ++++L+ G I
Sbjct: 157 EFGRLKVAQLLLNSHLCVALLEGEAKDPCD-PNYTTPLHLAAKNGHREVIRQLLRAG-IE 214
Query: 263 INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
IN + G T +H+AA G E ++ L++ G D NI N + D+ +F A + +
Sbjct: 215 INRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREI 273
Query: 323 EEL 325
++L
Sbjct: 274 KQL 276
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 14/166 (8%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F ++H A G + E++ L LL A + + G H AA +G+ V+ L+
Sbjct: 50 FSALHHAALGGSL----ELIAL--LLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR 103
Query: 87 NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
A + A G PLHLAA +GH +++L+ +P + +K + P+ A GRL
Sbjct: 104 ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKV 163
Query: 147 LQLLVK--------WGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV 184
QLL+ G + + D N P+HLAA GH + L+
Sbjct: 164 AQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
Score = 43.1 bits (100), Expect = 4e-04
Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 1/86 (1%)
Query: 241 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
H AA G L ++ L+E ++ + NG P+H AA QG +E ++ L++ A N +
Sbjct: 54 HHAALGGSLELIALLLE-AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAAS 112
Query: 301 KAGERPSDVAKRFAHLAAVKLLEELQ 326
G+ P +A ++ H ++L + Q
Sbjct: 113 LDGQIPLHLAAQYGHYEVSEMLLQHQ 138
Score = 32.0 bits (71), Expect = 0.98
Identities = 19/62 (30%), Positives = 32/62 (51%)
Query: 261 ININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVK 320
+N+N + +G + +H AA G +E + L++ A +I + G RP A L V+
Sbjct: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
Query: 321 LL 322
LL
Sbjct: 100 LL 101
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 99.8 bits (247), Expect = 4e-21
Identities = 86/307 (28%), Positives = 141/307 (45%), Gaps = 18/307 (5%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQALI-MN 87
+H A RAG ++ CL +L+ A R G T +H A+ G AC+Q L+
Sbjct: 40 VHHAARAG------KLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQG 93
Query: 88 GANLTAQDDRGCTPLHLAATHGHSFTLQIMLR-SGVDPSVTDKREWRPVHYAAFHGRLGC 146
G + +D+ G T LHLAA GH + +L G DP+ P+HYAA G
Sbjct: 94 GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPS 153
Query: 147 LQLLVK-WGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
L+LLV+ + + NG P++LA EGHL ++LV + A +G L
Sbjct: 154 LRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPH---ARAHDGMTPL 210
Query: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLK-KLVEDGVININ 264
A + ++ ++ +D++ A H AA +G +L L+ G I+ +
Sbjct: 211 HAAAQMGHSPVIVWLVSCTDVSLSEQDKDG-ATAMHFAASRGHTKVLSWLLLHGGEISAD 269
Query: 265 ERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
G TP+H AA G +EC Q L+ GA+ ++ ++ G +D++ H + L
Sbjct: 270 LW---GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRT 326
Query: 325 LQKYDID 331
++ ++
Sbjct: 327 VENLSVE 333
Score = 93.2 bits (230), Expect = 4e-19
Identities = 71/235 (30%), Positives = 114/235 (48%), Gaps = 9/235 (3%)
Query: 105 AATHGHSFTLQIMLRSGV-DPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDY- 162
AA G L+ + +G+ PS+ D + PVH+AA G+L CL+ LV+
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 163 NGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQG 222
NG P H A+ GHL C ++L+S+ Q +++G VL LA RF ++ ++
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDK---DNSGATVLHLAARFGHPEVVNWL-- 123
Query: 223 AEYEGKDLEDQETL-AFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQG 281
+ G D + A P H AA KGD L+ LVE +N + NG+TP++ A +G
Sbjct: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEG 183
Query: 282 HIECLQWLI-KMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENE 335
H+E Q+L+ + GAD + G P A + H + L + ++++
Sbjct: 184 HLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDK 238
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/143 (33%), Positives = 68/143 (47%), Gaps = 4/143 (2%)
Query: 55 GADITHVTTRGWTASHIAAIRGQDACVQALIM-NGANLTAQDDRGCTPLHLAATHGHSFT 113
GAD G T H AA G + L+ +L+ QD G T +H AA+ GH+
Sbjct: 196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKV 255
Query: 114 LQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAM 173
L +L G + S D P+H AA +G L C Q+LV G ++ D +G L+
Sbjct: 256 LSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDF 314
Query: 174 EGHLHCFKFL--VSRMSSATQVL 194
GH HC ++L V +S +VL
Sbjct: 315 NGHSHCTRYLRTVENLSVEHRVL 337
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 99.8 bits (247), Expect = 4e-21
Identities = 78/243 (32%), Positives = 119/243 (48%), Gaps = 12/243 (4%)
Query: 71 IAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKR 130
+AA +GQ V LI GA + A G TPLHLAA GH +QI+L++G D V D
Sbjct: 16 VAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
Query: 131 EWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSA 190
+ +H A G + L+ GC+++ D +GN +H A+ G K LV +
Sbjct: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV---KAG 131
Query: 191 TQVLKAFNDNGENVLDLA-QRFFKQNI-LQFIQGAEYEGKDLEDQETLAFPGHVAAFKGD 248
VL A N G L LA Q Q+ + + G+ + K+ L HVAA
Sbjct: 132 ANVL-AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCL----HVAARYNH 186
Query: 249 LGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSD 308
L +++ L+ +++E+ G T +H AA H + + L++ GAD+ I N AG+ P +
Sbjct: 187 LSIIRLLL-TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
Query: 309 VAK 311
A+
Sbjct: 246 TAR 248
Score = 65.5 bits (158), Expect = 8e-11
Identities = 49/181 (27%), Positives = 87/181 (48%), Gaps = 10/181 (5%)
Query: 29 SIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNG 88
++H A G+ +EI+ L+ G + G TA H A+ G + L+ G
Sbjct: 78 ALHRATVVGN----TEIIAA--LIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
Query: 89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
AN+ A++ G T LHLA + HS + +++L +G + + +H AA + L ++
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 208
LL+ CS+ + + G+ +H+AA H K L+ + T V N+ G+ L+ A
Sbjct: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV----NNAGQTPLETA 247
Query: 209 Q 209
+
Sbjct: 248 R 248
Score = 57.4 bits (137), Expect = 2e-08
Identities = 50/187 (26%), Positives = 87/187 (46%), Gaps = 12/187 (6%)
Query: 138 AAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAF 197
AA+ G+ + L+ G + V +G P+HLAA +GHL + L+ A L
Sbjct: 17 AAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLK----AGCDLDVQ 71
Query: 198 NDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKL 255
+D + L A I+ + +G + +D + L H A++ G K L
Sbjct: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTAL----HEASWHGFSQSAKLL 127
Query: 256 VEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAH 315
V+ G N+ + G+T +H A H + + L+ G+ +++ N AG+ VA R+ H
Sbjct: 128 VKAGA-NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNH 186
Query: 316 LAAVKLL 322
L+ ++LL
Sbjct: 187 LSIIRLL 193
Score = 55.8 bits (133), Expect = 6e-08
Identities = 42/158 (26%), Positives = 71/158 (44%), Gaps = 4/158 (2%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL G D+ TA H A + G + ALI G L QD G T LH A+ HG
Sbjct: 61 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 120
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHL 170
S + ++++++G + +K +H A + ++L+ G + + G+ +H+
Sbjct: 121 SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 180
Query: 171 AAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 208
AA HL + L++ S + N G+ L +A
Sbjct: 181 AARYNHLSIIRLLLTAFCSVHEK----NQAGDTALHVA 214
Score = 40.8 bits (94), Expect = 0.002
Identities = 26/102 (25%), Positives = 45/102 (44%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL G+ G T H+AA + ++ L+ ++ ++ G T LH+AA H
Sbjct: 160 LLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNH 219
Query: 111 SFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVK 152
+I+L +G D ++ + P+ A +H LL K
Sbjct: 220 KKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 97.1 bits (240), Expect = 2e-20
Identities = 78/285 (27%), Positives = 130/285 (45%), Gaps = 11/285 (3%)
Query: 45 IVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHL 104
I L L+ G+ I G A + AA G ++ L N L +D G LH+
Sbjct: 392 IQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHV 451
Query: 105 AATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNG 164
AA +GH+ Q++ G +P++ DK E P+H AA+HG + L + GC++ + G
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511
Query: 165 NLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QG 222
P+ A+ G + +V ++ L A + +G L LA R + +++ + QG
Sbjct: 512 ETPLLTASARG----YHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQG 567
Query: 223 AEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGH 282
+ +D P HVA G++ ++ L E N++ G TP+H AA G
Sbjct: 568 CFVDYQDRHGNT----PLHVACKDGNMPIVVALCEAN-CNLDISNKYGRTPLHLAANNGI 622
Query: 283 IECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQK 327
++ +++L MGA G+ D+A+ H LL L+K
Sbjct: 623 LDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRK 667
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/237 (26%), Positives = 107/237 (45%), Gaps = 40/237 (16%)
Query: 86 MNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLG 145
++ ++ + G PL +AA G+ LQ++++ G V DK V++AA HG +
Sbjct: 367 LSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD 426
Query: 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
L+ L + C ++ D +G + +H+AA GH + Q+L +F N N+
Sbjct: 427 TLKFLSENKCPLDVKDKSGEMALHVAARYGH-----------ADVAQLLCSFGSN-PNIQ 474
Query: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
D +++ET P H AA+ G + K L E G N+N
Sbjct: 475 D------------------------KEEET---PLHCAAWHGYYSVAKALCEAG-CNVNI 506
Query: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
+ G TP+ A+ +G+ + ++ L + GAD N +K G +A R + +K L
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTL 563
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 96.7 bits (239), Expect = 3e-20
Identities = 83/278 (29%), Positives = 124/278 (44%), Gaps = 22/278 (7%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
LL GA + V G TA H AA G + L+ GA+ A+ G TPLH AA GH
Sbjct: 93 LLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGH 152
Query: 111 SFTLQIMLRS-GVDPSVT---DKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNL 166
+ +L + G P+ D R W H+AA GRL L+LL G ++
Sbjct: 153 TLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA------ 206
Query: 167 PVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAE 224
+ +AA G +FL++R + + A + G L LA + ++ + GA+
Sbjct: 207 -LLVAAAAGRGAALRFLLARGAR----VDARDGAGATALGLAAALGRSQDIEVLLGHGAD 261
Query: 225 YEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIE 284
+D + L H AA +G L ++ LV G ++ R G TP+H A+ +GH+E
Sbjct: 262 PGIRDRHGRSAL----HRAAARGHLLAVQLLVTQGA-EVDARDTLGLTPLHHASREGHVE 316
Query: 285 CLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
L+ GA + T + P +A H V LL
Sbjct: 317 VAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLL 354
Score = 84.0 bits (206), Expect = 2e-16
Identities = 77/287 (26%), Positives = 122/287 (42%), Gaps = 15/287 (5%)
Query: 64 RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVD 123
+GW A RG V L+ GA++ +D G TPLHLA GH+ ++++L+ G
Sbjct: 40 QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99
Query: 124 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL 183
D+ +H AA+HG +LL++ G S G P+H AA GH L
Sbjct: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
Query: 184 VSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQ--GAEYEGKDLEDQETLAFPGH 241
+ +A + G A + +L+ + GA +G L
Sbjct: 160 LEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALL----------- 208
Query: 242 VAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNK 301
VAA G L+ L+ G ++ R G+T + AA G + ++ L+ GAD I ++
Sbjct: 209 VAAAAGRGAALRFLLARGA-RVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDR 267
Query: 302 AGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHG 348
G A HL AV+LL Q ++D + + + + R G
Sbjct: 268 HGRSALHRAAARGHLLAVQLL-VTQGAEVDARDTLGLTPLHHASREG 313
Score = 69.7 bits (169), Expect = 4e-12
Identities = 43/144 (29%), Positives = 70/144 (48%)
Query: 48 LHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAAT 107
L +LL GA + G TA +AA G+ ++ L+ +GA+ +D G + LH AA
Sbjct: 219 LRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAA 278
Query: 108 HGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLP 167
GH +Q+++ G + D P+H+A+ G + L+ G ++ + P
Sbjct: 279 RGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTP 338
Query: 168 VHLAAMEGHLHCFKFLVSRMSSAT 191
+HLAA GH L+SR +S T
Sbjct: 339 LHLAAERGHGPTVGLLLSRGASPT 362
Score = 47.4 bits (111), Expect = 2e-05
Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 35/118 (29%)
Query: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQD--------------- 95
LL HGAD G +A H AA RG VQ L+ GA + A+D
Sbjct: 255 LLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGH 314
Query: 96 --------DRGC----------TPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPV 135
DRG TPLHLAA GH T+ ++L G P++ + +W V
Sbjct: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL--RTQWAEV 370
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 94.7 bits (234), Expect = 1e-19
Identities = 85/320 (26%), Positives = 141/320 (44%), Gaps = 35/320 (10%)
Query: 10 STSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTAS 69
++++ E P +R+ + +A R GDV+++ +V + + R T
Sbjct: 14 ASAAAEAVEPAARE------LFEACRNGDVERVKRLVTPEKV-----NSRDTAGRKSTPL 62
Query: 70 HIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDK 129
H AA G+ V+ L+ NGAN+ A+DD G PLH A + GH+ + ++LR G DP+ D
Sbjct: 63 HFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDN 122
Query: 130 REWRPVHYAAFHGRLGCLQLLVKWGC--SIEDVDYNGNL----PVHLAAMEGHLHCFKFL 183
+ P+H AA G++ +L++ G +I + D L P A + G + L
Sbjct: 123 WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELL 182
Query: 184 VSRMSSATQVLKAF-----------NDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDL 230
S S + + A + L LA + + I+Q + GA+ KD
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 231 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 290
D P H A G + + LV+ G +N TP+H+AA + +E L+
Sbjct: 243 GD----LVPLHNACSYGHYEVTELLVKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 291 KMGADSNITNKAGERPSDVA 310
GAD + N + D+A
Sbjct: 298 SYGADPTLLNCHNKSAIDLA 317
Score = 88.2 bits (217), Expect = 1e-17
Identities = 66/228 (28%), Positives = 101/228 (44%), Gaps = 19/228 (8%)
Query: 95 DDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWG 154
+ R TPLH AA + ++ +L+ G D DK P+H A +G +LLVK G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
Query: 155 CSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQ 214
+ D P+H AA +G K L+ + T+ N +G LDL
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK----NRDGNTPLDL------- 631
Query: 215 NILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPM 274
++ + + +DL + AA KG L +KKL +N + STP+
Sbjct: 632 -----VKDGDTDIQDLLRGDAALLD---AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPL 683
Query: 275 HKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
H AAG ++E ++L++ GAD N +K G P A + H+ LL
Sbjct: 684 HLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALL 731
Score = 84.3 bits (207), Expect = 2e-16
Identities = 65/270 (24%), Positives = 124/270 (45%), Gaps = 24/270 (8%)
Query: 32 DAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANL 91
+A +AGDV+ + ++ + + + R T H AA + + V+ L+ +GA++
Sbjct: 498 EAAKAGDVETVKKLCTVQ-----SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 92 TAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 151
A+D G PLH A ++GH +++++ G +V D ++ P+H AA G+ +LL+
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 152 KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRF 211
+ G + +GN P+ L T + + +LD A++
Sbjct: 613 QHGADPTKKNRDGNTPLDLV---------------KDGDTDIQDLLRGDAA-LLDAAKKG 656
Query: 212 FKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGS 271
+ + +D + + + P H+AA +L + + L++ G ++N + G
Sbjct: 657 CLARVKKLSSPDNVNCRDTQGRHST--PLHLAAGYNNLEVAEYLLQHGA-DVNAQDKGGL 713
Query: 272 TPMHKAAGQGHIECLQWLIKMGADSNITNK 301
P+H AA GH++ LIK A N T+K
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNATDK 743
Score = 72.0 bits (175), Expect = 9e-13
Identities = 70/274 (25%), Positives = 127/274 (46%), Gaps = 22/274 (8%)
Query: 40 KQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGC 99
KQ+ E+ LL GA+I T T H+A+ + + V+ ++ + A + A D+ G
Sbjct: 380 KQICEL-----LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
Query: 100 TPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIED 159
T LH AA GH T +++L G DP++ + + + + +Q L++ G S+ +
Sbjct: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGN 489
Query: 160 VDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQF 219
+ + L AA G + K L + S + ++ L A + + +++++
Sbjct: 490 SEADRQLLE--AAKAGDVETVKKLCTVQSVNCRDIEG---RQSTPLHFAAGYNRVSVVEY 544
Query: 220 I--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKA 277
+ GA+ KD + P H A G + + LV+ G + +N TP+H+A
Sbjct: 545 LLQHGADVHAKD----KGGLVPLHNACSYGHYEVAELLVKHGAV-VNVADLWKFTPLHEA 599
Query: 278 AGQGHIECLQWLIKMGADSNITNKAGERPSDVAK 311
A +G E + L++ GAD N+ G P D+ K
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
Score = 71.6 bits (174), Expect = 1e-12
Identities = 61/227 (26%), Positives = 99/227 (43%), Gaps = 18/227 (7%)
Query: 100 TPLHLAATHGHSFTLQI---MLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCS 156
T LH AA + QI +LR G + + K P+H A+ ++++VK
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
Query: 157 IEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQV-LKAFNDNGENVLDLAQRFFKQN 215
+ +D G +H AA GHL + L+S + L+ F A + +N
Sbjct: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT---------ALQMGNEN 476
Query: 216 ILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMH 275
+ Q +Q G D++ L AA GD+ +KKL +N + STP+H
Sbjct: 477 VQQLLQEGISLGNSEADRQLLE-----AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531
Query: 276 KAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
AAG + +++L++ GAD + +K G P A + H +LL
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578
Score = 56.2 bits (134), Expect = 5e-08
Identities = 33/108 (30%), Positives = 53/108 (49%)
Query: 67 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
T H+AA + L+ +GA++ AQD G PLH AA++GH ++++ +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740
Query: 127 TDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAME 174
TDK + P+H AA GR LL+ G + G P+ L + +
Sbjct: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
Score = 47.0 bits (110), Expect = 3e-05
Identities = 27/80 (33%), Positives = 41/80 (51%)
Query: 243 AAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKA 302
A GD+ +K+LV +N + A STP+H AAG G + +++L++ GA+ +
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
Query: 303 GERPSDVAKRFAHLAAVKLL 322
G P A F H V LL
Sbjct: 91 GLIPLHNACSFGHAEVVNLL 110
Score = 30.0 bits (66), Expect = 3.7
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 6/96 (6%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
+H+A G V ++ L L+ + A + +T H AA +G+ L+ +GA
Sbjct: 716 LHNAASYGHV----DVAAL--LIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPS 125
+ T ++ G TPL L + S L + PS
Sbjct: 770 DPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 92.4 bits (228), Expect = 6e-19
Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 52/285 (18%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
I AV AGDV + + +L G GWT H +A RG++ CV+ + +GA
Sbjct: 18 IQAAVAAGDVHTVRK------MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
Query: 90 NLTAQD-DRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE---WRPVHYAAFHGRLG 145
+ T +D G T LH AA HG + ++ML S + + + W P+H AA +GR
Sbjct: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
Query: 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
++LL+++ ++ + G P+ LA + C K L+ D+ N+
Sbjct: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--------------DHNANI- 176
Query: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
D+++ L + A K + + ++ G
Sbjct: 177 -----------------------DIQNGFLLRY----AVIKSNHSYCRMFLQRGADTNLG 209
Query: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
R ++G TP+H +A + + C + L GAD+N N G+ P V+
Sbjct: 210 RLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
Score = 48.9 bits (115), Expect = 8e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 22/165 (13%)
Query: 25 VHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQA 83
+H+ ++H R + SE + +DI + + GWT H+AA G+D+ V+
Sbjct: 85 LHYAAMHGRARIARLMLESE---------YRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
Query: 84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143
L+ A + D+G TPL LA S ++I+L + D + + YA
Sbjct: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN---IDIQNGFLLRYAVIKSN 192
Query: 144 LGCLQLLVKWGCS-----IEDVDYNGNLPVHLAAMEGHLHCFKFL 183
++ ++ G +ED G P+HL+A+ + C + L
Sbjct: 193 HSYCRMFLQRGADTNLGRLED----GQTPLHLSALRDDVLCARML 233
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 92.4 bits (228), Expect = 6e-19
Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 52/285 (18%)
Query: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
I AV AGDV + + +L G GWT H +A RG++ CV+ + +GA
Sbjct: 18 IQAAVAAGDVHTVRK------MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
Query: 90 NLTAQD-DRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE---WRPVHYAAFHGRLG 145
+ T +D G T LH AA HG + ++ML S + + + W P+H AA +GR
Sbjct: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
Query: 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
++LL+++ ++ + G P+ LA + C K L+ D+ N+
Sbjct: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--------------DHNANI- 176
Query: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
D+++ L + A K + + ++ G
Sbjct: 177 -----------------------DIQNGFLLRY----AVIKSNHSYCRMFLQRGADTNLG 209
Query: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
R ++G TP+H +A + + C + L GAD+N N G+ P V+
Sbjct: 210 RLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
Score = 48.9 bits (115), Expect = 8e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 22/165 (13%)
Query: 25 VHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQA 83
+H+ ++H R + SE + +DI + + GWT H+AA G+D+ V+
Sbjct: 85 LHYAAMHGRARIARLMLESE---------YRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
Query: 84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143
L+ A + D+G TPL LA S ++I+L + D + + YA
Sbjct: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN---IDIQNGFLLRYAVIKSN 192
Query: 144 LGCLQLLVKWGCS-----IEDVDYNGNLPVHLAAMEGHLHCFKFL 183
++ ++ G +ED G P+HL+A+ + C + L
Sbjct: 193 HSYCRMFLQRGADTNLGRLED----GQTPLHLSALRDDVLCARML 233
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 89.4 bits (220), Expect = 5e-18
Identities = 86/323 (26%), Positives = 136/323 (42%), Gaps = 56/323 (17%)
Query: 29 SIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIA------------AIRG 76
++H A AG ++ LL +G+D + ++ +G+TA+ + IR
Sbjct: 594 ALHRAALAGHLQTC------RLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRT 647
Query: 77 QDACVQAL-------------IMNGANLTAQDDRG--CTPLHLAATHGHSFTLQIMLRSG 121
D + L + + N+ +D G TPLH AA + ++ +L G
Sbjct: 648 SDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
Query: 122 VDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFK 181
D DK P+H A +G +LLV+ G S+ D P+H AA +G K
Sbjct: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
Query: 182 FLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGH 241
L+ + T+ N +G LDL + EG D + Q+ L
Sbjct: 768 LLLKHGADPTKK----NRDGNTPLDLVK----------------EG-DTDIQDLLRGDAA 806
Query: 242 V--AAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNIT 299
+ AA KG L ++KL IN + STP+H AAG ++E ++L++ GAD N
Sbjct: 807 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866
Query: 300 NKAGERPSDVAKRFAHLAAVKLL 322
+K G P A + H+ LL
Sbjct: 867 DKGGLIPLHNAASYGHVDIAALL 889
Score = 85.1 bits (209), Expect = 1e-16
Identities = 80/300 (26%), Positives = 131/300 (43%), Gaps = 33/300 (11%)
Query: 32 DAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTAS--HIAAIRGQDACVQALIMNGA 89
+A R GDV ++ +V A++ G +S H AA G+ V+ L+ GA
Sbjct: 188 EACRNGDVSRVKRLV-------DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
Query: 90 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 149
N+ A+DD G PLH A + GH+ + ++L G DP+ D + P+H AA G++ +
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
Query: 150 LVKWGC--SIEDVDYNGNL----PVHLAAMEGHLHCFKFLVSRMSSATQVLKAF------ 197
L++ G +I + D L P A + G + L + S + L A
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
Query: 198 -----NDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLG 250
+ L LA + + I+Q + GA+ KD + P H A G
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD----KGGLVPLHNACSYGHYE 416
Query: 251 MLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
+ + L++ G +N TP+H+AA + +E L+ GAD + N G+ D+A
Sbjct: 417 VTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 85.1 bits (209), Expect = 1e-16
Identities = 92/365 (25%), Positives = 144/365 (39%), Gaps = 86/365 (23%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIA---- 72
A+P +R ++ +H+A G + VC+ LL HGAD T G +A +A
Sbjct: 273 ADPNARDNWNYTPLHEAAIKGKID-----VCIV-LLQHGADPNIRNTDGKSALDLADPSA 326
Query: 73 ----------------AIRGQDACVQALIMN-GANLTAQDDRGCTPLHLAATHGHSFTLQ 115
A G + + AL+ N A D R TPLHLAA + +Q
Sbjct: 327 KAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQ 386
Query: 116 IMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEG 175
++L+ G D DK P+H A +G +LL+K G + +D P+H AA +
Sbjct: 387 LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKN 446
Query: 176 HLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQET 235
+ L+S + T V N +G++ +D+A +L ++ T
Sbjct: 447 RVEVCSLLLSHGADPTLV----NCHGKSAVDMAPT-----------------PELRERLT 485
Query: 236 LAFPGHV---AAFKGDLGMLKKLVEDGVIN------------------------------ 262
F GH AA + DL +KK + +IN
Sbjct: 486 YEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLL 545
Query: 263 -----INERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLA 317
+NE+ + TP+H AA + H + ++ L K GA N + G+ A HL
Sbjct: 546 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQ 605
Query: 318 AVKLL 322
+LL
Sbjct: 606 TCRLL 610
Score = 84.7 bits (208), Expect = 1e-16
Identities = 70/270 (25%), Positives = 125/270 (46%), Gaps = 24/270 (8%)
Query: 32 DAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANL 91
+A +AGD++ + ++ + + R T H AA + + V+ L+ +GA++
Sbjct: 656 EASKAGDLETVKQLCSSQ-----NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADV 710
Query: 92 TAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 151
A+D G PLH A ++GH ++++R G +V D ++ P+H AA G+ +LL+
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 152 KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRF 211
K G + +GN P+ L EG L R +A +LD A++
Sbjct: 771 KHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL--RGDAA-------------LLDAAKKG 814
Query: 212 FKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGS 271
+ + +D + + + P H+AA +L + + L+E G ++N + G
Sbjct: 815 CLARVQKLCTPENINCRDTQGRNST--PLHLAAGYNNLEVAEYLLEHGA-DVNAQDKGGL 871
Query: 272 TPMHKAAGQGHIECLQWLIKMGADSNITNK 301
P+H AA GH++ LIK N T+K
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDK 901
Score = 77.4 bits (189), Expect = 2e-14
Identities = 84/302 (27%), Positives = 131/302 (43%), Gaps = 34/302 (11%)
Query: 13 SRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIA 72
S ETA C+ +H KQ++E+ LL GA++ T H+A
Sbjct: 521 SHETALHCAVASLH----------PKRKQVTEL-----LLRKGANVNEKNKDFMTPLHVA 565
Query: 73 AIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREW 132
A R + ++ L +GA + A D G T LH AA GH T +++L G DPS+ + +
Sbjct: 566 AERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF 625
Query: 133 RPVHYAAFHGRLGCLQLLVK-WGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSAT 191
AA G Q+L + DVDY + A+ G L K L S +
Sbjct: 626 T----AAQMGNEAVQQILSESTPIRTSDVDYR----LLEASKAGDLETVKQLCSSQNVNC 677
Query: 192 QVLKAFNDNGENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDL 249
+ L+ L A + + ++++++ GA+ KD + P H A G
Sbjct: 678 RDLEG---RHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD----KGGLVPLHNACSYGHY 730
Query: 250 GMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDV 309
+ + LV G ++N TP+H+AA +G E + L+K GAD N+ G P D+
Sbjct: 731 EVAELLVRHGA-SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
Query: 310 AK 311
K
Sbjct: 790 VK 791
Score = 61.2 bits (147), Expect = 2e-09
Identities = 55/205 (26%), Positives = 82/205 (40%), Gaps = 35/205 (17%)
Query: 27 FGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM 86
F +H+A G + +C LL HGAD T G T + ++ D +Q L+
Sbjct: 751 FTPLHEAAAKGKYE-----IC-KLLLKHGADPTKKNRDGNTPLDL--VKEGDTDIQDLLR 802
Query: 87 NGANLTAQDDRGC-----------------------TPLHLAATHGHSFTLQIMLRSGVD 123
A L +GC TPLHLAA + + + +L G D
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
Query: 124 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL 183
+ DK P+H AA +G + LL+K+ + D P+H AA +G L
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
Query: 184 VSRMSSATQVLKAFNDNGENVLDLA 208
++ + T N G+ LDLA
Sbjct: 923 LAHGADPTMK----NQEGQTPLDLA 943
Score = 57.4 bits (137), Expect = 2e-08
Identities = 35/111 (31%), Positives = 54/111 (48%)
Query: 64 RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVD 123
R T H+AA + L+ +GA++ AQD G PLH AA++GH ++++
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
Query: 124 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAME 174
+ TDK + P+H AA GR LL+ G + G P+ LA +
Sbjct: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
Score = 49.3 bits (116), Expect = 6e-06
Identities = 27/80 (33%), Positives = 43/80 (53%)
Query: 243 AAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKA 302
A GD+ +K+LV+ +N + A S+P+H AAG G + ++ L++MGA+ + +
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 303 GERPSDVAKRFAHLAAVKLL 322
G P A F H V LL
Sbjct: 249 GLIPLHNACSFGHAEVVSLL 268
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 88.6 bits (218), Expect = 9e-18
Identities = 57/161 (35%), Positives = 81/161 (50%), Gaps = 6/161 (3%)
Query: 29 SIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNG 88
++H A AG +EIV +LL G + GW+ HIAA G+D V+AL+ G
Sbjct: 43 ALHWACSAGH----TEIV--EFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
A + A + GCTPLH AA+ ++L G +P D E +H AA G L +
Sbjct: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSS 189
+L+ + S D GN P+HLA E + K LVS+ +S
Sbjct: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
Score = 71.6 bits (174), Expect = 1e-12
Identities = 65/235 (27%), Positives = 101/235 (42%), Gaps = 42/235 (17%)
Query: 89 ANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQ 148
A T QD R T LH A + GH+ ++ +L+ GV + D W P+H AA GR ++
Sbjct: 33 ATRTDQDSR--TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVK 90
Query: 149 LLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 208
L+ G + V+ NG P+H AA + +R A +L+
Sbjct: 91 ALLGKGAQVNAVNQNGCTPLHYAASK----------NRHEIAVMLLEG------------ 128
Query: 209 QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERAD 268
GA + KD + + H AA KG+L M+ L+ + N +
Sbjct: 129 -------------GANPDAKDHYEATAM----HRAAAKGNLKMIHILLYYKA-STNIQDT 170
Query: 269 NGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLE 323
G+TP+H A + +E + L+ GA I NK + P VAK L +++E
Sbjct: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVE 225
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/194 (27%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 67 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
TA H A G V+ L+ G + +DD G +PLH+AA+ G ++ +L G +
Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Query: 127 TDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 186
++ P+HYAA R +L++ G + + D+ +H AA +G+L L+
Sbjct: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
Query: 187 MSSATQVLKAFNDNGENVLDLA--QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAA 244
+S + G L LA + ++ L QGA ++ E++ L
Sbjct: 162 KAST----NIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL------QV 211
Query: 245 FKGDLGM-LKKLVE 257
KG LG+ LK++VE
Sbjct: 212 AKGGLGLILKRMVE 225
Score = 33.5 bits (75), Expect = 0.34
Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
ANP ++ ++H A G++K + H LL++ A T G T H+A
Sbjct: 130 ANPDAKDHYEATAMHRAAAKGNLKMI------HILLYYKASTNIQDTEGNTPLHLACDEE 183
Query: 77 QDACVQALIMNGANLTAQDDRGCTPLHLA 105
+ + L+ GA++ ++ TPL +A
Sbjct: 184 RVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,928,026
Number of Sequences: 37866
Number of extensions: 630251
Number of successful extensions: 5462
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 347
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1458
Number of HSP's gapped (non-prelim): 1947
length of query: 389
length of database: 18,247,518
effective HSP length: 104
effective length of query: 285
effective length of database: 14,309,454
effective search space: 4078194390
effective search space used: 4078194390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.