Search of human proteins with 23510413

Search of human proteins with 23510413

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510413 sorting nexin 26 [Homo sapiens]
         (1126 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510413 sorting nexin 26 [Homo sapiens]                          2331   0.0  
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]   669   0.0  
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]    396   e-110
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap...   315   1e-85
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...   315   1e-85
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]           302   1e-81
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   141   3e-33
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   141   3e-33
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            136   1e-31
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          136   1e-31
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     130   7e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    130   7e-30
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...   130   7e-30
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...   130   7e-30
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           126   1e-28
gi|54860105 nadrin isoform 2 [Homo sapiens]                           125   2e-28
gi|188497642 ARHGAP15 [Homo sapiens]                                  124   4e-28
gi|54860079 nadrin isoform 1 [Homo sapiens]                           124   7e-28
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]               121   3e-27
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s...   111   4e-24
gi|229094128 active breakpoint cluster region-related  protein i...   109   1e-23
gi|38679957 active breakpoint cluster region-related  protein is...   109   1e-23
gi|38679954 active breakpoint cluster region-related  protein is...   109   1e-23
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          108   3e-23
gi|156119615 myosin IXA [Homo sapiens]                                104   5e-22
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]           101   3e-21
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        100   1e-20
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        100   1e-20
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]            99   2e-20
gi|91208437 GEM interacting protein [Homo sapiens]                     98   4e-20

>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score = 2331 bits (6041), Expect = 0.0
 Identities = 1126/1126 (100%), Positives = 1126/1126 (100%)

Query: 1    MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG 60
            MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
Sbjct: 1    MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG 60

Query: 61   HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS 120
            HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
Sbjct: 61   HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS 120

Query: 121  CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE 180
            CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
Sbjct: 121  CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE 180

Query: 181  ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS 240
            ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS
Sbjct: 181  ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS 240

Query: 241  ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ 300
            ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ
Sbjct: 241  ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ 300

Query: 301  RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR 360
            RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR
Sbjct: 301  RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR 360

Query: 361  LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE 420
            LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE
Sbjct: 361  LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE 420

Query: 421  RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES 480
            RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES
Sbjct: 421  RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES 480

Query: 481  VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST 540
            VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST
Sbjct: 481  VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST 540

Query: 541  RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG 600
            RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG
Sbjct: 541  RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG 600

Query: 601  PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASAT 660
            PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASAT
Sbjct: 601  PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASAT 660

Query: 661  PTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLS 720
            PTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLS
Sbjct: 661  PTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLS 720

Query: 721  LLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGG 780
            LLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGG
Sbjct: 721  LLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGG 780

Query: 781  EPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSA 840
            EPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSA
Sbjct: 781  EPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSA 840

Query: 841  QLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQ 900
            QLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQ
Sbjct: 841  QLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQ 900

Query: 901  PSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGM 960
            PSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGM
Sbjct: 901  PSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGM 960

Query: 961  LGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSP 1020
            LGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSP
Sbjct: 961  LGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSP 1020

Query: 1021 ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPA 1080
            ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPA
Sbjct: 1021 ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPA 1080

Query: 1081 YGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC 1126
            YGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
Sbjct: 1081 YGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC 1126


>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
          Length = 2087

 Score =  669 bits (1725), Expect = 0.0
 Identities = 367/670 (54%), Positives = 463/670 (69%), Gaps = 61/670 (9%)

Query: 2   VARSTDSLDGPGEGSVQPLPTAGGP-SVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG 60
           +AR  D  + PG+ +   L T G   S+K K  K+L   +G FP++A+CAHFHYENV+FG
Sbjct: 75  MARGADVPEIPGDLT---LKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFG 131

Query: 61  HIQLLLSPDREGPSLSG--ENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRR 118
            IQL LS ++     +G    ELV+ VQ+ CQG+SW V RSY+DFR LD HLH CI+DRR
Sbjct: 132 SIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRR 191

Query: 119 FSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLS 178
           FS L ELP       + + +  +L+ YL  LS +  + +NCGP LTWME+DN G  LL+ 
Sbjct: 192 FSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVH 251

Query: 179 EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFF 238
           EE+S+N PAV AAHVIKRYTA+APDEL+ EVGDIVSVIDMPP    +WWRGK GFQVG F
Sbjct: 252 EESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLF 311

Query: 239 PSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRP----RGKLAGLLRTFMR 294
           P  CVEL  ++                  PQ   S+T++VP+P     GKL   LRTFM+
Sbjct: 312 PGHCVELINQK-----------------VPQ---SVTNSVPKPVSKKHGKLITFLRTFMK 351

Query: 295 SRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGV 354
           SRP++Q+L+QRGIL++RVFGCDLGEHL NSG +VPQVL+ C+ FIE +G+VDGIYRLSGV
Sbjct: 352 SRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGV 411

Query: 355 SSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMS 414
           +SNIQRLRHEFDSE +P+L+   ++QDIHSV SLCKLYFRELPNPLLTYQLY KFS+A+S
Sbjct: 412 ASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVS 471

Query: 415 VPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLR 474
              +EERL+++HDVIQQLPPPHYRTLE+L+RHL+ +A + + T+MHA+NLAIVWAPNLLR
Sbjct: 472 AATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLR 531

Query: 475 SMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLA 534
           S ++ES    G AAF EVR+QSVVVEF+L HVDVLFS   + A  +  G   L RPKSL 
Sbjct: 532 SKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQE--GAASLSRPKSLL 589

Query: 535 GSCPSTRLLTLEEAQARTQGRLGTP--TEP---TTPKAPAS-----------PAERRKGE 578
            S PST+LLTLEEAQARTQ ++ +P  TE       + PA+           P ER++ +
Sbjct: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649

Query: 579 RGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQP------SGSRPDTVTLR 632
              K +K    SW++FF LG+  SV ++K    L    + P         G R +  TLR
Sbjct: 650 --NKMKKSPVGSWRSFFNLGKSSSVSKRK----LQRNESEPSEMKAMALKGGRAEG-TLR 702

Query: 633 SAKSEESLSS 642
           SAKSEESL+S
Sbjct: 703 SAKSEESLTS 712



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 19/26 (73%), Positives = 22/26 (84%)

Query: 728  PPPPPKNPARLMALALAERAQQVAEQ 753
            PPPPPKN AR++ALALAE AQQ + Q
Sbjct: 1032 PPPPPKNVARMLALALAESAQQASTQ 1057


>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
          Length = 1738

 Score =  396 bits (1018), Expect = e-110
 Identities = 216/372 (58%), Positives = 272/372 (73%), Gaps = 31/372 (8%)

Query: 293 MRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLS 352
           M+SRP++Q+L+QRGIL++RVFGCDLGEHL NSG +VPQVL+ C+ FIE +G+VDGIYRLS
Sbjct: 1   MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 60

Query: 353 GVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEA 412
           GV+SNIQRLRHEFDSE +P+L+   ++QDIHSV SLCKLYFRELPNPLLTYQLY KFS+A
Sbjct: 61  GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 120

Query: 413 MSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNL 472
           +S   +EERL+++HDVIQQLPPPHYRTLE+L+RHL+ +A + + T+MHA+NLAIVWAPNL
Sbjct: 121 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180

Query: 473 LRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKS 532
           LRS ++ES    G AAF EVR+QSVVVEF+L HVDVLFS   + A  +  G   L RPKS
Sbjct: 181 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQE--GAASLSRPKS 238

Query: 533 LAGSCPSTRLLTLEEAQARTQGRLGTP--TEP---TTPKAPAS-----------PAERRK 576
           L  S PST+LLTLEEAQARTQ ++ +P  TE       + PA+           P ER++
Sbjct: 239 LLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKR 298

Query: 577 GERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQP------SGSRPDTVT 630
            +   K +K    SW++FF LG+  SV ++K    L    + P         G R +  T
Sbjct: 299 PQ--NKMKKSPVGSWRSFFNLGKSSSVSKRK----LQRNESEPSEMKAMALKGGRAEG-T 351

Query: 631 LRSAKSEESLSS 642
           LRSAKSEESL+S
Sbjct: 352 LRSAKSEESLTS 363



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 19/26 (73%), Positives = 22/26 (84%)

Query: 728 PPPPPKNPARLMALALAERAQQVAEQ 753
           PPPPPKN AR++ALALAE AQQ + Q
Sbjct: 683 PPPPPKNVARMLALALAESAQQASTQ 708


>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
           sapiens]
          Length = 890

 Score =  315 bits (808), Expect = 1e-85
 Identities = 186/369 (50%), Positives = 237/369 (64%), Gaps = 16/369 (4%)

Query: 298 SRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSN 357
           SRQ+ +++G  ++RVFGCDL EHL +SGQ+VPQVL+ C+EF+E +GVVDGIYRLSGVSSN
Sbjct: 3   SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62

Query: 358 IQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPG 417
           IQ+LR EF+SER P+L    +LQDIH VSSLCK YFRELP+PLLTY+LY KF+EA+ V  
Sbjct: 63  IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122

Query: 418 EEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSME 477
           E ERLV++ +V+++LP P+YRTLE+L+RHL  MA  SA T+MHARNLAIVWAPNLLRS +
Sbjct: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182

Query: 478 LESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSC 537
           +E+ G  G AAF EVRVQS+VVEF+LTHVD LF     S G   +G   LP  ++ +GS 
Sbjct: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRA-SGSP 241

Query: 538 PSTRLLTLE-EAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFA 596
                  L     +  Q   G P              +RKG    K RK     W++ F 
Sbjct: 242 EDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSL--KVRK-----WRSIFN 294

Query: 597 LGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAP 656
           LGR     ++K LP     R      G      TLR AKS +SLS+ A  ++       P
Sbjct: 295 LGRSGHETKRK-LPRGAEDREDKSNKG------TLRPAKSMDSLSAAAGASDEPEGLVGP 347

Query: 657 ASATPTPAL 665
           +S  P+P L
Sbjct: 348 SSPRPSPLL 356


>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
           sapiens]
          Length = 1101

 Score =  315 bits (808), Expect = 1e-85
 Identities = 186/369 (50%), Positives = 237/369 (64%), Gaps = 16/369 (4%)

Query: 298 SRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSN 357
           SRQ+ +++G  ++RVFGCDL EHL +SGQ+VPQVL+ C+EF+E +GVVDGIYRLSGVSSN
Sbjct: 3   SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62

Query: 358 IQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPG 417
           IQ+LR EF+SER P+L    +LQDIH VSSLCK YFRELP+PLLTY+LY KF+EA+ V  
Sbjct: 63  IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122

Query: 418 EEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSME 477
           E ERLV++ +V+++LP P+YRTLE+L+RHL  MA  SA T+MHARNLAIVWAPNLLRS +
Sbjct: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182

Query: 478 LESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSC 537
           +E+ G  G AAF EVRVQS+VVEF+LTHVD LF     S G   +G   LP  ++ +GS 
Sbjct: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRA-SGSP 241

Query: 538 PSTRLLTLE-EAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFA 596
                  L     +  Q   G P              +RKG    K RK     W++ F 
Sbjct: 242 EDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSL--KVRK-----WRSIFN 294

Query: 597 LGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAP 656
           LGR     ++K LP     R      G      TLR AKS +SLS+ A  ++       P
Sbjct: 295 LGRSGHETKRK-LPRGAEDREDKSNKG------TLRPAKSMDSLSAAAGASDEPEGLVGP 347

Query: 657 ASATPTPAL 665
           +S  P+P L
Sbjct: 348 SSPRPSPLL 356


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score =  302 bits (773), Expect = 1e-81
 Identities = 177/358 (49%), Positives = 233/358 (65%), Gaps = 14/358 (3%)

Query: 293 MRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLS 352
           M+++ ++Q+L+++G      FGCDL E+L +SGQDVP VL+ C+EFIE HG+VDGIYRLS
Sbjct: 1   MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLS 58

Query: 353 GVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEA 412
           GV+SNIQRLR EF S++ P+L+   +LQDIH V SLCKLYFRELPNPLLTY+LY KF+EA
Sbjct: 59  GVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEA 118

Query: 413 MSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNL 472
           +S   EE +L R+ +VIQ+LPP HYRTLEYL+RHLA +A  S+ T+MHARNLA+VWAPNL
Sbjct: 119 VSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNL 178

Query: 473 LRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKS 532
           LRS E+E+ G  G AAF  VRVQ VV+EF+L HVD +F++    +  +   R ++     
Sbjct: 179 LRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTL 238

Query: 533 LAGSCPSTRLLTLEEAQART----QGRLGTPTEPTTPK--APASPAERRKGERGEKQRKP 586
            A S P  +L++LEEAQAR+            E + P+   P         E  + +RK 
Sbjct: 239 PALSLP-MKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKL 297

Query: 587 GGSS--WKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSS 642
              S  WK+ F LGR  S  + K L   G      Q      +  T+R AKS +SL S
Sbjct: 298 SSKSKKWKSIFNLGRSGSDSKSK-LSRNGSVFVRGQRLS--VEKATIRPAKSMDSLCS 352



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 49/172 (28%), Positives = 70/172 (40%), Gaps = 40/172 (23%)

Query: 705 PLGPDMESPLPP-----PPLSLLRPGGAPPPP-----------PKNPARLMALALAERAQ 748
           P+ P +ES L P     PP SL  P G+ P P           P N +   A   A R +
Sbjct: 681 PIQPILESSLGPFIPSEPPGSL--PCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREK 738

Query: 749 QVAEQQSQQECGGTPPASQSPFHRS---LSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGP 805
              EQ    +     P    PF ++    ++EVGG           P +L+ P    P P
Sbjct: 739 PEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGG-----------PGNLSPP--LPPAP 785

Query: 806 PPYLPRQQSDGSLLRSQRP-MGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAA 856
           PP  P ++S   LL    P    S R LR    +  QL++    +D+PE ++
Sbjct: 786 PPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYID-QLKS----QDSPEISS 832


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  141 bits (356), Expect = 3e-33
 Identities = 107/358 (29%), Positives = 168/358 (46%), Gaps = 41/358 (11%)

Query: 160 GPVLTWMELDNHGRRLLLS------EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIV 213
           G  L+W   D   R+ +L        E  +   + A      +  AQ   ELS E     
Sbjct: 195 GATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAE----- 249

Query: 214 SVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISS 273
               +PP E  S        +V F  SE       R G   + + D  P       G   
Sbjct: 250 ----LPPEESES-------SRVDFGSSE-------RLGSWQEKEEDARPNAAAPALGPVG 291

Query: 274 LTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLR 333
           L S + + R KL    R F++ RP+ Q LR++G ++ +VFGC L          VP+ ++
Sbjct: 292 LESDLSKVRHKL----RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQ 347

Query: 334 CCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLY 392
            C   +EA G+ +DG+YR+SG  + IQ+LR++ D +   +L    + +D+H ++   KL+
Sbjct: 348 QCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLF 406

Query: 393 FRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMAR 452
           FRELP PL  +  + +F  A+ +  +  R   V D+++ LP P++ TL  L +HL R+  
Sbjct: 407 FRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIE 466

Query: 453 HSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
           H     M  +++AIV+ P LLR  E+E   M     F     Q+ VVE +L     +F
Sbjct: 467 HGEQNRMSVQSVAIVFGPTLLRP-EVEETSMPMTMVF-----QNQVVELILQQCADIF 518


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  141 bits (356), Expect = 3e-33
 Identities = 107/358 (29%), Positives = 168/358 (46%), Gaps = 41/358 (11%)

Query: 160 GPVLTWMELDNHGRRLLLS------EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIV 213
           G  L+W   D   R+ +L        E  +   + A      +  AQ   ELS E     
Sbjct: 222 GATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAE----- 276

Query: 214 SVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISS 273
               +PP E  S        +V F  SE       R G   + + D  P       G   
Sbjct: 277 ----LPPEESES-------SRVDFGSSE-------RLGSWQEKEEDARPNAAAPALGPVG 318

Query: 274 LTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLR 333
           L S + + R KL    R F++ RP+ Q LR++G ++ +VFGC L          VP+ ++
Sbjct: 319 LESDLSKVRHKL----RKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQ 374

Query: 334 CCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLY 392
            C   +EA G+ +DG+YR+SG  + IQ+LR++ D +   +L    + +D+H ++   KL+
Sbjct: 375 QCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLF 433

Query: 393 FRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMAR 452
           FRELP PL  +  + +F  A+ +  +  R   V D+++ LP P++ TL  L +HL R+  
Sbjct: 434 FRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIE 493

Query: 453 HSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
           H     M  +++AIV+ P LLR  E+E   M     F     Q+ VVE +L     +F
Sbjct: 494 HGEQNRMSVQSVAIVFGPTLLRP-EVEETSMPMTMVF-----QNQVVELILQQCADIF 545


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  136 bits (343), Expect = 1e-31
 Identities = 74/202 (36%), Positives = 116/202 (57%), Gaps = 6/202 (2%)

Query: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSE 368
           ++V+ CDL   +       P V+  C   IE+ G+  +G+YR+SG S  I+ ++  FD +
Sbjct: 263 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 322

Query: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                      +DI+ ++   KLYFR+LP PL+TY  Y KF E+  +   +E+L  +H+ 
Sbjct: 323 GEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEA 382

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           ++ LPP H  TL YL+ HL R+  H     M+A NL IV+ P L+RS EL+++     AA
Sbjct: 383 LKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM-----AA 437

Query: 489 FREVRVQSVVVEFLLTHVDVLF 510
             ++R Q +VVE L+ + D+LF
Sbjct: 438 LNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  136 bits (343), Expect = 1e-31
 Identities = 74/202 (36%), Positives = 116/202 (57%), Gaps = 6/202 (2%)

Query: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSE 368
           ++V+ CDL   +       P V+  C   IE+ G+  +G+YR+SG S  I+ ++  FD +
Sbjct: 237 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 296

Query: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                      +DI+ ++   KLYFR+LP PL+TY  Y KF E+  +   +E+L  +H+ 
Sbjct: 297 GEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEA 356

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           ++ LPP H  TL YL+ HL R+  H     M+A NL IV+ P L+RS EL+++     AA
Sbjct: 357 LKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM-----AA 411

Query: 489 FREVRVQSVVVEFLLTHVDVLF 510
             ++R Q +VVE L+ + D+LF
Sbjct: 412 LNDIRYQRLVVELLIKNEDILF 433


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  130 bits (327), Expect = 7e-30
 Identities = 70/202 (34%), Positives = 113/202 (55%), Gaps = 6/202 (2%)

Query: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV-DGIYRLSGVSSNIQRLRHEFDSE 368
           ++V+ CDL   +       P V+  C   IEA G+  +G+YR+SG + +I+ ++  FD +
Sbjct: 272 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 331

Query: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                       DI+ ++   KLYFR+LP P++TY  Y KF +A  +   +ERL  VH+V
Sbjct: 332 GEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEV 391

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           +  LPP HY TL YL+ HL ++  +  +  M+A NL IV+ P L+R  E  ++       
Sbjct: 392 LMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTL-----TT 446

Query: 489 FREVRVQSVVVEFLLTHVDVLF 510
             ++R Q ++V+ L+ + DVLF
Sbjct: 447 LHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  130 bits (327), Expect = 7e-30
 Identities = 70/202 (34%), Positives = 113/202 (55%), Gaps = 6/202 (2%)

Query: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV-DGIYRLSGVSSNIQRLRHEFDSE 368
           ++V+ CDL   +       P V+  C   IEA G+  +G+YR+SG + +I+ ++  FD +
Sbjct: 136 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 195

Query: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                       DI+ ++   KLYFR+LP P++TY  Y KF +A  +   +ERL  VH+V
Sbjct: 196 GEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEV 255

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           +  LPP HY TL YL+ HL ++  +  +  M+A NL IV+ P L+R  E  ++       
Sbjct: 256 LMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTL-----TT 310

Query: 489 FREVRVQSVVVEFLLTHVDVLF 510
             ++R Q ++V+ L+ + DVLF
Sbjct: 311 LHDMRYQKLIVQILIENEDVLF 332


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score =  130 bits (327), Expect = 7e-30
 Identities = 87/253 (34%), Positives = 125/253 (49%), Gaps = 23/253 (9%)

Query: 271 ISSLTSAVPRPRG----KLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQ 326
           +SS  S++  P G    ++   L+  +  RP  Q L++RG+LR +VFGC L       G 
Sbjct: 475 LSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGD 534

Query: 327 DVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSER---------IPELSGP 376
            VP  LR C   ++  G+ VDGIYR+SG  + +Q+LR   D ER          PE  G 
Sbjct: 535 TVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQ 594

Query: 377 --------AFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                       DIH V+   KL+ RELP PL+   L   F  A+++   E+ L ++ ++
Sbjct: 595 EGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQEL 654

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           I  +P P++ TL YLL HL R+  HS    M   NL IV+ P L R  E E+      A 
Sbjct: 655 IGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRP-EQETSDPAAHAL 713

Query: 489 FREVRVQSVVVEF 501
           +    VQ ++  F
Sbjct: 714 YPGQLVQLMLTNF 726


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score =  130 bits (327), Expect = 7e-30
 Identities = 87/253 (34%), Positives = 125/253 (49%), Gaps = 23/253 (9%)

Query: 271 ISSLTSAVPRPRG----KLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQ 326
           +SS  S++  P G    ++   L+  +  RP  Q L++RG+LR +VFGC L       G 
Sbjct: 291 LSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGD 350

Query: 327 DVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSER---------IPELSGP 376
            VP  LR C   ++  G+ VDGIYR+SG  + +Q+LR   D ER          PE  G 
Sbjct: 351 TVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQ 410

Query: 377 --------AFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428
                       DIH V+   KL+ RELP PL+   L   F  A+++   E+ L ++ ++
Sbjct: 411 EGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQEL 470

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           I  +P P++ TL YLL HL R+  HS    M   NL IV+ P L R  E E+      A 
Sbjct: 471 IGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRP-EQETSDPAAHAL 529

Query: 489 FREVRVQSVVVEF 501
           +    VQ ++  F
Sbjct: 530 YPGQLVQLMLTNF 542


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  126 bits (316), Expect = 1e-28
 Identities = 75/223 (33%), Positives = 127/223 (56%), Gaps = 9/223 (4%)

Query: 289 LRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDG 347
           L+ F+  RP+ Q +R++G ++ +VFG +L          VP+ ++ C E +E HG+ +DG
Sbjct: 630 LKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDG 689

Query: 348 IYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYG 407
           IYR+SG  + IQ+LR   + +   +L+   + +DIH ++   K++FRELP PL T+  + 
Sbjct: 690 IYRVSGNLAVIQKLRFAVNHDEKLDLNDSKW-EDIHVITGALKMFFRELPEPLFTFNHFN 748

Query: 408 KFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIV 467
            F  A+      +R+  V D+I+QLP P+  T++ L RHL R+  +     M  +++AIV
Sbjct: 749 DFVNAIKQE-PRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIV 807

Query: 468 WAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
           + P LL+  E E+    G  A   V  Q+ +VE +L  +  +F
Sbjct: 808 FGPTLLKP-EKET----GNIAVHTV-YQNQIVELILLELSSIF 844


>gi|54860105 nadrin isoform 2 [Homo sapiens]
          Length = 803

 Score =  125 bits (314), Expect = 2e-28
 Identities = 144/564 (25%), Positives = 220/564 (39%), Gaps = 85/564 (15%)

Query: 282 RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEA 341
           R  LA L +T    R  + +  ++       FG  L EHL  SG+++   +  C   +  
Sbjct: 224 RKALAVLEKTLPEMRAHQDKWAEKP-----AFGTPLEEHLKRSGREIALPIEACVMLLLE 278

Query: 342 HGVVD-GIYRLSGVSSNIQRLRHEFD--SERIPELSGPAFLQDIHSVSSLCKLYFRELPN 398
            G+ + G++R+   +S +++L+   D  +  + E     F  D H+V+   K Y RELP 
Sbjct: 279 TGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDE-----FYSDPHAVAGALKSYLRELPE 333

Query: 399 PLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTS 458
           PL+T+ LY ++++  SV  ++++L  +    Q+LPP ++    YL++ LA++A+ S    
Sbjct: 334 PLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNK 393

Query: 459 MHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF-------- 510
           M   N+AIV  PNLL +    ++    AA    V     V+E ++ H D  F        
Sbjct: 394 MTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV---VAVIEPIIQHADWFFPEEVEFNV 450

Query: 511 SDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPAS 570
           S+ F       +         S +G+    R      + A  +G L     P  PK P S
Sbjct: 451 SEAFVPLTTPSSNHSFHTGNDSDSGTLERKR----PASMAVMEGDLVKKESPPKPKDPVS 506

Query: 571 PAERRKGERGEK----QRKPGGSSWKTFFALGR-----GPSVPR-----KKPLPWLGGTR 616
            A    G    +    Q +P  ++     ++G+     GPS        KKP P      
Sbjct: 507 AAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAP------ 560

Query: 617 APPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASATPTPALSPGRSLRPHLI 676
           APP+P    P                   G    G    P S +P P   P RS  P   
Sbjct: 561 APPKPGNPPP---------------GHPGGQSSSGTSQHPPSLSPKP---PTRSPSP--- 599

Query: 677 PLLLRG-----AEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPP 731
           P    G       AP   +  +   S L   Q P  P  + P    PL   +P    PP 
Sbjct: 600 PTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPN 659

Query: 732 PKNPARLMALALAERAQQVAEQQSQQEC-GGTPP-ASQSPFHRSLSLEVGGEPLGT---S 786
           P      MAL      +Q +    Q      TPP   Q+P   +     GG P      +
Sbjct: 660 P------MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHA 713

Query: 787 GSGPPPNSLAHPGAWVPGPPPYLP 810
           G+ P P  +  P      PPP  P
Sbjct: 714 GTLPRPRPVPKPRNRPSVPPPPQP 737



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 64/257 (24%), Positives = 95/257 (36%), Gaps = 20/257 (7%)

Query: 815  DGSLLRSQ---RPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQV--PTP 869
            +G L++ +   +P       +  P + ++Q+ +G     A   + Q     P     P+P
Sbjct: 489  EGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSP 548

Query: 870  GFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIG 929
                 A ++  P     PKPG  P G P  Q SS       SL P  P           G
Sbjct: 549  HTLRRAVKKPAP---APPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTG 605

Query: 930  ASEGSP-----YSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCF 984
               G P      S P R  S    +              +P +H  P+     PP P   
Sbjct: 606  QPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPN--SQGPPNPMAL 663

Query: 985  PPDHLGYSAPQH-PARRPTPPEPLYVNLALGPRGPSPASSSSSSP-PAHPRSRSDPGP-P 1041
            P +H G   P H P + PTPP    +     P  P+P + +  +P  A P + + P P P
Sbjct: 664  PSEH-GLEQPSHTPPQTPTPPSTPPLG-KQNPSLPAPQTLAGGNPETAQPHAGTLPRPRP 721

Query: 1042 VPRLPQKQRAPWGPRTP 1058
            VP+   +   P  P+ P
Sbjct: 722  VPKPRNRPSVPPPPQPP 738



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 52/186 (27%), Positives = 71/186 (38%), Gaps = 30/186 (16%)

Query: 962  GQSPPLH---RSPDFLLSYPPAPSCFPPDHLGYSAPQH---PARRPTPPEPLY------- 1008
            G  PP H   +S      +PP+ S  PP        QH   P  +P+ P  L        
Sbjct: 566  GNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSS 625

Query: 1009 -VNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVP-RLPQKQRAPWGPRTPHRVPGPWG 1066
             ++    P  P P   + ++P  H +  S  GPP P  LP +        TP + P P  
Sbjct: 626  SLSPIQAPNHPPPQPPTQATPLMHTKPNSQ-GPPNPMALPSEHGLEQPSHTPPQTPTPPS 684

Query: 1067 PPEPLLLYRAAPPAYG--RGG-----ELHRGSLYRN---GGQRGEGAGPPPPYPTPSWSL 1116
             P PL     + PA     GG     + H G+L R       R   + PPPP P     +
Sbjct: 685  TP-PLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPP---GV 740

Query: 1117 HSEGQT 1122
            HS G +
Sbjct: 741  HSAGDS 746



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 32/129 (24%), Positives = 42/129 (32%), Gaps = 24/129 (18%)

Query: 994  PQHPARRPTP-PEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAP 1052
            P+ P     P P      +A G   P  A+ S       P + + P P   R   K+ AP
Sbjct: 501  PKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAP 560

Query: 1053 WGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTP 1112
                          PP+P       PP    GG+   G+      Q      P PP  +P
Sbjct: 561  -------------APPKP-----GNPPPGHPGGQSSSGT-----SQHPPSLSPKPPTRSP 597

Query: 1113 SWSLHSEGQ 1121
            S      GQ
Sbjct: 598  SPPTQHTGQ 606


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  124 bits (312), Expect = 4e-28
 Identities = 72/230 (31%), Positives = 125/230 (54%), Gaps = 8/230 (3%)

Query: 282 RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEA 341
           + ++   L+ F+  RPS + L+++G+++ ++FG  L +        VP  ++ C E +E 
Sbjct: 248 KNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEK 307

Query: 342 HGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPL 400
            G+ VDGIYR+SG  + IQ+LR   + E    L    + +DIH V+   K++FRELP PL
Sbjct: 308 RGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPL 366

Query: 401 LTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMH 460
             Y  + +F EA+       R+  V  ++Q+LPPP+  T++ L  HL ++   ++   M 
Sbjct: 367 FPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMS 426

Query: 461 ARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
            ++L IV+ P LLR+ E E+  M     +     Q+ + E +L+    +F
Sbjct: 427 TQSLGIVFGPTLLRA-ENETGNMAIHMVY-----QNQIAELMLSEYSKIF 470


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score =  124 bits (310), Expect = 7e-28
 Identities = 158/668 (23%), Positives = 253/668 (37%), Gaps = 105/668 (15%)

Query: 282 RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEA 341
           R  LA L +T    R  + +  ++       FG  L EHL  SG+++   +  C   +  
Sbjct: 224 RKALAVLEKTLPEMRAHQDKWAEKP-----AFGTPLEEHLKRSGREIALPIEACVMLLLE 278

Query: 342 HGVVD-GIYRLSGVSSNIQRLRHEFD--SERIPELSGPAFLQDIHSVSSLCKLYFRELPN 398
            G+ + G++R+   +S +++L+   D  +  + E     F  D H+V+   K Y RELP 
Sbjct: 279 TGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDE-----FYSDPHAVAGALKSYLRELPE 333

Query: 399 PLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTS 458
           PL+T+ LY ++++  SV  ++++L  +    Q+LPP ++    YL++ LA++A+ S    
Sbjct: 334 PLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNK 393

Query: 459 MHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSD------ 512
           M   N+AIV  PNLL +    ++    AA    V     V+E ++ H D  F +      
Sbjct: 394 MTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV---VAVIEPIIQHADWFFPEEVEFNV 450

Query: 513 --------------TFTSAGLDPAGRCLLPRPKSLA---GSCPSTRLLTLEEAQARTQGR 555
                         +F +     +G     RP S+A   G         ++    +   R
Sbjct: 451 SEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRR 510

Query: 556 LGT------------PTEPT--TPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGP 601
            GT            P  PT  +   PA P    +  R E     GG+   +   L +GP
Sbjct: 511 GGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESS-SGGGTVPSSAGILEQGP 569

Query: 602 SVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQ-----ASGAELLGAGGAP 656
           S           G  +PP+P       V      + +  S Q     A+G+  L  G   
Sbjct: 570 S----------PGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPH 619

Query: 657 ASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPP 716
            +A P+P        +P   P    G   P     Q    +          P   SP PP
Sbjct: 620 NAAGPSPHTLRRAVKKPAPAP-PKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPP 678

Query: 717 PPLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSL 776
                 +  G PP  P  P++L   A    +  ++  Q+       PP   +P   +   
Sbjct: 679 -----TQHTGQPPGQPSAPSQLS--APRRYSSSLSPIQAPNHPPPQPPTQATPLMHT--- 728

Query: 777 EVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPA 836
                      S  PPN +A P       P + P Q        +  P  T   G + P+
Sbjct: 729 --------KPNSQGPPNPMALPSEHGLEQPSHTPPQ--------TPTPPSTPPLGKQNPS 772

Query: 837 QVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGP 896
             + Q  AGG     PE A     ++P   P P    P  R  +PP      PG++  G 
Sbjct: 773 LPAPQTLAGGN----PETAQPHAGTLPRPRPVP---KPRNRPSVPP--PPQPPGVHSAGD 823

Query: 897 PSFQPSSP 904
            S   ++P
Sbjct: 824 SSLTNTAP 831



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 96/361 (26%), Positives = 124/361 (34%), Gaps = 71/361 (19%)

Query: 706  LGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPA 765
            + P  + PLPP   S + P G  PPP  + A                       GGT P+
Sbjct: 519  ISPAFQPPLPPTDGSTVVPAGPEPPPQSSRA------------------ESSSGGGTVPS 560

Query: 766  SQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPM 825
            S         LE G  P    G G PP       A VP P         + S + S +  
Sbjct: 561  SAG------ILEQGPSP----GDGSPPKPKDPVSAAVPAP-------GRNNSQIASGQNQ 603

Query: 826  GTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLG 885
              +  G       S QL  G        AA  SP ++   V  P   +PAP         
Sbjct: 604  PQAAAG-------SHQLSMG----QPHNAAGPSPHTLRRAVKKP---APAP--------- 640

Query: 886  VPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSP-----YSGPT 940
             PKPG  P G P  Q SS       SL P  P           G   G P      S P 
Sbjct: 641  -PKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPR 699

Query: 941  RSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQH-PAR 999
            R  S    +              +P +H  P+     PP P   P +H G   P H P +
Sbjct: 700  RYSSSLSPIQAPNHPPPQPPTQATPLMHTKPN--SQGPPNPMALPSEH-GLEQPSHTPPQ 756

Query: 1000 RPTPPEPLYVNLALGPRGPSPASSSSSSP-PAHPRSRSDPGP-PVPRLPQKQRAPWGPRT 1057
             PTPP    +     P  P+P + +  +P  A P + + P P PVP+   +   P  P+ 
Sbjct: 757  TPTPPSTPPLG-KQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQP 815

Query: 1058 P 1058
            P
Sbjct: 816  P 816



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 57/225 (25%), Positives = 76/225 (33%), Gaps = 61/225 (27%)

Query: 897  PSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNA 956
            P+FQP  P P   S++ P  P              E  P S    S S   ++P     +
Sbjct: 521  PAFQPPLP-PTDGSTVVPAGP--------------EPPPQSSRAESSSGGGTVP-----S 560

Query: 957  SYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPR 1016
            S G+L Q P    SP      PP P     D +  + P  P R  +        +A G  
Sbjct: 561  SAGILEQGP----SPGD--GSPPKPK----DPVSAAVPA-PGRNNS-------QIASGQN 602

Query: 1017 GPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRA 1076
             P  A+ S       P + + P P   R   K+ AP              PP+P      
Sbjct: 603  QPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAP-------------APPKP-----G 644

Query: 1077 APPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQ 1121
             PP    GG+   G+      Q      P PP  +PS      GQ
Sbjct: 645  NPPPGHPGGQSSSGT-----SQHPPSLSPKPPTRSPSPPTQHTGQ 684


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score =  121 bits (304), Expect = 3e-27
 Identities = 127/477 (26%), Positives = 178/477 (37%), Gaps = 94/477 (19%)

Query: 311 RVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSER 369
           RV+G  L  HL   G+++   +  C   + + G+ + G++RL+  +S ++RL+    S+ 
Sbjct: 272 RVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASD- 330

Query: 370 IPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVI 429
               S   F  D H+V+   K Y RELP PL+T+ LY  +  A S+     RL  + +V 
Sbjct: 331 --PHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVC 388

Query: 430 QQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAF 489
            +LPP +   L YL++ LAR+A       M   N+AIV  PNLL   E E    G  A  
Sbjct: 389 SRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKE----GDQAQL 444

Query: 490 REVRVQSV----VVEFLLTHVDVLFSD--TFTSAGL----------------DPAGRCLL 527
               V S+    VVE L+   D LF     F  +GL                +      +
Sbjct: 445 DAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAV 504

Query: 528 PRPKSLAGSCPS---TRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQR 584
           P P +     P+        L  A  + +     P  P +PK   SP E         +R
Sbjct: 505 PTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARR 564

Query: 585 KPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQA 644
                                K+P P    T  PPQ SGSR                S  
Sbjct: 565 --------------------TKRPAP-ARPTMPPPQVSGSR----------------SSP 587

Query: 645 SGAELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQG 704
               L    G+P +    P    G SLR   +P        PL     Q    + R +  
Sbjct: 588 PAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVP-------PPLPPTPPQPARRQSRRSPA 640

Query: 705 PLGPDMESPLPPPPLSLLRP-----------GGAP------PPPPKNPARLMALALA 744
              P    P  P P+SL  P           GGAP      P PP  P +    +LA
Sbjct: 641 SPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLA 697



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 58/193 (30%), Positives = 78/193 (40%), Gaps = 34/193 (17%)

Query: 850  DAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWR 909
            + P  A  +P + P+  P P   +PAP   L       K       PP  +P+SP  V R
Sbjct: 498  ELPSTAVPTPATTPAPAPAP---APAPAPALAS--AATKERTESEVPP--RPASPK-VTR 549

Query: 910  SSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFR-SMPPDRLNASYGMLGQSPPLH 968
            S     AP++                 +  T+  +P R +MPP +++ S      SPP  
Sbjct: 550  SPPETAAPVE---------------DMARRTKRPAPARPTMPPPQVSGSRS----SPPAP 590

Query: 969  RSPDFLLSYPPAPSCFPPDHLGYS--APQ-HPARRPTPPEPLYVNLALGPRGPSPASSSS 1025
              P    S P  P   P   +G S  AP   P   PTPP+P        P  PSPAS   
Sbjct: 591  PLPPGSGS-PGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGP 649

Query: 1026 SSPPAHPRSRSDP 1038
            +SP   P S S+P
Sbjct: 650  ASP--SPVSLSNP 660



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 56/212 (26%), Positives = 74/212 (34%), Gaps = 29/212 (13%)

Query: 711 ESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERAQ-QVAEQQSQQECGGTPPASQSP 769
           E P    P     P  AP P P     L + A  ER + +V  + +  +   +PP + +P
Sbjct: 498 ELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAP 557

Query: 770 FH-------RSLSLEVGGEPLGTSGS-GPPPNSLAHPGAWVPGPPPYLPRQQSDGSL--- 818
                    R         P   SGS   PP     PG+  PG P  LPR+    SL   
Sbjct: 558 VEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAP 617

Query: 819 -----LRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFS 873
                L    P    R+  R PA  S           +P  A+ SP S+ +        +
Sbjct: 618 TVPPPLPPTPPQPARRQSRRSPASPSPA---------SPGPASPSPVSLSNPAQVDLGAA 668

Query: 874 PAPRECLPPFLGVPKPGLYPLGPPSFQPSSPA 905
            A         GVP P   P  PP  +P S A
Sbjct: 669 TAEGGAPEAISGVPTP---PAIPPQPRPRSLA 697



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 46/172 (26%), Positives = 63/172 (36%), Gaps = 28/172 (16%)

Query: 965  PPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPS--PAS 1022
            PP   SP    S  P  +  P + +     +    RPT P P        P  P   P S
Sbjct: 539  PPRPASPKVTRS--PPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGS 596

Query: 1023 SSSSSPPAHPR----------SRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLL 1072
             S  +P A PR          +   P PP P  P ++++   P +P   P   GP  P  
Sbjct: 597  GSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPS--PASPGPASP-- 652

Query: 1073 LYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPP-----PPYPTPSWSLHSE 1119
                +P +     ++  G+    GG     +G P     PP P P  SL SE
Sbjct: 653  ----SPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPR-SLASE 699



 Score = 30.4 bits (67), Expect = 9.9
 Identities = 31/129 (24%), Positives = 42/129 (32%), Gaps = 30/129 (23%)

Query: 979  PAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGP--------------RGPSPASSS 1024
            PAP+  P   L  +A +       PP P    +   P              + P+PA  +
Sbjct: 515  PAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPT 574

Query: 1025 SSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRT-PHRVPG------------PWGPPEPL 1071
               P       S P PP   LP    +P  P+  P R+ G            P  PP+P 
Sbjct: 575  MPPPQVSGSRSSPPAPP---LPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPA 631

Query: 1072 LLYRAAPPA 1080
                   PA
Sbjct: 632  RRQSRRSPA 640


>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
           sapiens]
          Length = 874

 Score =  111 bits (277), Expect = 4e-24
 Identities = 94/343 (27%), Positives = 164/343 (47%), Gaps = 38/343 (11%)

Query: 332 LRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHE-FDSERIPELSGPAFLQDIHSVSSLC 389
           +R C + +E  G+ + G+YR+ GV+S +Q+L +  F  +  P++     L D  +++S  
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457

Query: 390 KLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLAR 449
           K Y R L  PL+TY+L+  F  A+    +  R+  VH ++ +LP  +   L+ L++HL +
Sbjct: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517

Query: 450 MARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVL 509
           ++ HS    M   NL +++ P L+R+ E E+V     AA   ++ Q++VVE L+ H + +
Sbjct: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE-ETV-----AAMMNIKFQNIVVEILIEHYEKI 571

Query: 510 FSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTP--TEPTTPKA 567
           F          P     LP+P+S +GS   TR + L     + +GR  TP   EP +   
Sbjct: 572 FHTA-------PDPSIPLPQPQSRSGS-RRTRAICLSTGSRKPRGRY-TPCLAEPDSDSY 622

Query: 568 PASPAERRKG--ERGEKQRKPGGSSWKTFFALGRGPSVPRKKP--LPWLGGTRAPPQPSG 623
            +SP     G  E          S+ K+          PR+K   +PW+    A P  S 
Sbjct: 623 SSSPDSTPMGSIESLSSHSSEQNSTTKS------ASCQPREKSGGIPWI----ATPSSSN 672

Query: 624 SRPD----TVTLRSAKSEESLSSQA-SGAELLGAGGAPASATP 661
            +      T +  S+  E++  + A S  + + +  +P   +P
Sbjct: 673 GQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSP 715


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score =  109 bits (273), Expect = 1e-23
 Identities = 75/207 (36%), Positives = 112/207 (54%), Gaps = 9/207 (4%)

Query: 312 VFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSERI 370
           VFG  +          VP ++R C E +E  G+ + GIYR+SGV+++IQ L+  FD+   
Sbjct: 598 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 657

Query: 371 PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSE--AMSVPGEEERLVRVHDV 428
             L   + + DI++++   KLYFRELP PLLT +LY  F E  A+S P  +E  +    +
Sbjct: 658 DILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMM--HL 714

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           ++ LP P+  T  +LL HL R+A       M   NLA V+ P LLR  E+ES     +AA
Sbjct: 715 LRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAA 774

Query: 489 ---FREVRVQSVVVEFLLTHVDVLFSD 512
                +V  Q  V+ + L H  + F++
Sbjct: 775 DIWSHDVMAQVQVLLYYLQHPPISFAE 801


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score =  109 bits (273), Expect = 1e-23
 Identities = 75/207 (36%), Positives = 112/207 (54%), Gaps = 9/207 (4%)

Query: 312 VFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSERI 370
           VFG  +          VP ++R C E +E  G+ + GIYR+SGV+++IQ L+  FD+   
Sbjct: 644 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 703

Query: 371 PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSE--AMSVPGEEERLVRVHDV 428
             L   + + DI++++   KLYFRELP PLLT +LY  F E  A+S P  +E  +    +
Sbjct: 704 DILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMM--HL 760

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           ++ LP P+  T  +LL HL R+A       M   NLA V+ P LLR  E+ES     +AA
Sbjct: 761 LRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAA 820

Query: 489 ---FREVRVQSVVVEFLLTHVDVLFSD 512
                +V  Q  V+ + L H  + F++
Sbjct: 821 DIWSHDVMAQVQVLLYYLQHPPISFAE 847


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score =  109 bits (273), Expect = 1e-23
 Identities = 75/207 (36%), Positives = 112/207 (54%), Gaps = 9/207 (4%)

Query: 312 VFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSERI 370
           VFG  +          VP ++R C E +E  G+ + GIYR+SGV+++IQ L+  FD+   
Sbjct: 607 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 666

Query: 371 PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSE--AMSVPGEEERLVRVHDV 428
             L   + + DI++++   KLYFRELP PLLT +LY  F E  A+S P  +E  +    +
Sbjct: 667 DILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMM--HL 723

Query: 429 IQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAA 488
           ++ LP P+  T  +LL HL R+A       M   NLA V+ P LLR  E+ES     +AA
Sbjct: 724 LRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAA 783

Query: 489 ---FREVRVQSVVVEFLLTHVDVLFSD 512
                +V  Q  V+ + L H  + F++
Sbjct: 784 DIWSHDVMAQVQVLLYYLQHPPISFAE 810


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  108 bits (270), Expect = 3e-23
 Identities = 109/385 (28%), Positives = 163/385 (42%), Gaps = 50/385 (12%)

Query: 311  RVFGCDLGE-HLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSE 368
            R FG  L E   +   Q VP ++  C   +EA G+   GIYR+ G ++ +  L+ + +  
Sbjct: 807  RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNR- 865

Query: 369  RIPELSGPAFL-------QDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEER 421
                  GP  +       QD++ +SSL K +FR+LP PL T   Y  F EA  +    ER
Sbjct: 866  ------GPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARER 919

Query: 422  LVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESV 481
            +  +  +I+ LP  +Y TL++L+ HL  +A HS    M  RNLA+V+ P L+R+ E    
Sbjct: 920  MRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMT 979

Query: 482  GMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAG----------RCLLPR-P 530
             M        +  +  +VE L+ H D  FSD        P G            LLP   
Sbjct: 980  DM-----VTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIG 1034

Query: 531  KSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPA---SPAERRKGERGEKQRKPG 587
            +++    P +   T   + A+++G      EP   +  A     A  RK ++  + R  G
Sbjct: 1035 RTVPPGDPGSDSTTC--SSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLG 1092

Query: 588  GS----SWKTFFALGRGPSVP--RKKPLPWLGGTRAPPQPSGSRP-------DTVTLRSA 634
             S    S +     G G + P  +++P   L G  AP  P    P            RS 
Sbjct: 1093 SSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSI 1152

Query: 635  KSEESLSSQASGAELLGAGGAPASA 659
             S  S  S    +   GA G  A A
Sbjct: 1153 VSGYSTLSTMDRSVCSGASGRRAGA 1177



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 33/113 (29%), Positives = 44/113 (38%), Gaps = 12/113 (10%)

Query: 935  PYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAP 994
            PYSG  RS        P+     Y     +PP   S    +  P   S  P D    +A 
Sbjct: 80   PYSGEARSI-------PEPPPICYPRKTYAPPARASTRATM-VPEPTSALPSDPRSPAAW 131

Query: 995  QHPARRPTPPEPLYV-NLALGPRGPSPASSSS---SSPPAHPRSRSDPGPPVP 1043
              P  R  P    ++ N +LG   P P+  +    SS P  PR+  +PG  VP
Sbjct: 132  SDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVP 184


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score =  104 bits (259), Expect = 5e-22
 Identities = 66/170 (38%), Positives = 97/170 (57%), Gaps = 9/170 (5%)

Query: 308  LRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFD 366
            L  R FG +L   L++  + VP V+     +IE HG+  +GIYR SG ++ I+ LR   D
Sbjct: 2056 LSSRQFGVELSR-LTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLD 2114

Query: 367  SERIPELSGPAFLQD--IHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVR 424
            ++     +    L D  IH ++S+ K + R+LPNPL+T++LY +F  AM +   +E +  
Sbjct: 2115 TD-----AESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRG 2169

Query: 425  VHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLR 474
            V+ VI QL   H  TLE L+ HL R+A       M A  LAIV+AP +LR
Sbjct: 2170 VYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILR 2219


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score =  101 bits (252), Expect = 3e-21
 Identities = 107/406 (26%), Positives = 169/406 (41%), Gaps = 59/406 (14%)

Query: 331 VLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLR---------HEFDSERIPELSGPAFLQ 380
           ++R C   +E  G+ D G+YR+ GVSS +QRL          +E D E   +        
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADW------- 450

Query: 381 DIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTL 440
           ++ +++S  K Y R LP PL+TY+L+G F         E R+  +H ++ +LP  +   L
Sbjct: 451 EVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEML 510

Query: 441 EYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVE 500
           + L++HL  ++ HS    M   NL +V+ P L+R  E E+V     AA  +++ Q++VVE
Sbjct: 511 DILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQE-ETV-----AALMDLKFQNIVVE 564

Query: 501 FLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPT 560
            L+ + + +F     +           P P  L+ S P+        A  R   R G  T
Sbjct: 565 ILIENHEKIFRTPPDTT---------FPEPTCLSASPPN--------APPRQSKRQGQRT 607

Query: 561 E-PTTPKAPASPAERRKGERGEKQRKPGG-----SSWKTFFALGRGPSVPRKKPLPWLGG 614
           + P          E        K+  P       SS         GP  P K  L   GG
Sbjct: 608 KRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGG 667

Query: 615 T---RAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELL-GAGGAPASATPTPALSPGRS 670
           +    A   P  +R   V   + +S  + SS ++   L  G+   P S   T A  P   
Sbjct: 668 SFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKP--- 724

Query: 671 LRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPP 716
                 P  +R  +A     C+ E  S+L    G +  D+++   P
Sbjct: 725 ------PESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREP 764


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  100 bits (248), Expect = 1e-20
 Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 2/170 (1%)

Query: 312  VFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSERI 370
            VFG  +          VP ++R C E IE  G+ + GIYR+SGV+++IQ L+  FD    
Sbjct: 1007 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN- 1065

Query: 371  PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQ 430
             ++S      D+++++   KLYFRELP PL T + Y  F+E +++     +   + +++ 
Sbjct: 1066 KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1125

Query: 431  QLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES 480
             LP  +  T  +LL HL R+A   A   M   NLA V+ P LLR  E ES
Sbjct: 1126 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1175


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  100 bits (248), Expect = 1e-20
 Identities = 61/170 (35%), Positives = 92/170 (54%), Gaps = 2/170 (1%)

Query: 312  VFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSERI 370
            VFG  +          VP ++R C E IE  G+ + GIYR+SGV+++IQ L+  FD    
Sbjct: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN- 1109

Query: 371  PELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQ 430
             ++S      D+++++   KLYFRELP PL T + Y  F+E +++     +   + +++ 
Sbjct: 1110 KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169

Query: 431  QLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES 480
             LP  +  T  +LL HL R+A   A   M   NLA V+ P LLR  E ES
Sbjct: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219


>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
          Length = 946

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 61/185 (32%), Positives = 94/185 (50%), Gaps = 6/185 (3%)

Query: 290 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV-DGI 348
           R F +SR  R   +      QR+FG D+ + + +SGQ VP V+  C  FI  +G+  +GI
Sbjct: 486 RKFQKSRQPRPSSQYN----QRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGI 541

Query: 349 YRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGK 408
           +R+SG    +  +R  F+    P + G     D+ SV+ + KLYFR L  PL    L+G+
Sbjct: 542 FRVSGAQLRVSEIRDAFERGEDPLVEG-CTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE 600

Query: 409 FSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVW 468
              +  +    ER+  V  ++ +LP P    L YL   L  +A++S    M   NLA+ +
Sbjct: 601 LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF 660

Query: 469 APNLL 473
            P LL
Sbjct: 661 GPTLL 665



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 17/62 (27%), Positives = 29/62 (46%), Gaps = 3/62 (4%)

Query: 184 NIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECV 243
           ++  V  A     YT +   ELSF  GD++ + +   ++   WWRG+     G  P + +
Sbjct: 744 DLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSD---WWRGEHNGMRGLIPHKYI 800

Query: 244 EL 245
            L
Sbjct: 801 TL 802


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 109/391 (27%), Positives = 167/391 (42%), Gaps = 53/391 (13%)

Query: 309 RQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDS 367
           R  +FG D  +   +  ++VP V+  C+  IE   + V GIYR+SG    ++RL   F++
Sbjct: 545 RTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFEN 604

Query: 368 ER-IPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSV----PGEE--- 419
            R + ELSG       H VSS+ K + +EL  P++ + LY  F          PG++   
Sbjct: 605 GRALVELSG----NSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGT 660

Query: 420 -----ERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLR 474
                E +  +  ++ QLP  +Y TL +L+ HL R+A       M A NL IV+ P LLR
Sbjct: 661 PSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLR 720

Query: 475 SMELESVGMGGAAAFREVRV-----QSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR 529
             +    G   A+A     +     Q+ +VEFL+ H + +F         +P  +   P 
Sbjct: 721 PPD----GPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPA 776

Query: 530 PKSLAGSC--------PSTRLLTL--------EEAQARTQGRLGTPTEPTTPKAP--ASP 571
           P  L  S         P ++   L        +      Q    TPTE  TP++      
Sbjct: 777 PGPLTTSSQPPPPHLDPDSQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDV 836

Query: 572 AERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTL 631
           AE  K   GE   +    S     + G     P K P    GG R    P   +  ++ L
Sbjct: 837 AEDTKDGGGEVSSQGPEDSLLGTQSRGHFSRQPVKYP---RGGVR----PVTHQLSSLAL 889

Query: 632 RSAK-SEESLSSQASGAELLGAGGAPASATP 661
            ++K  EE+  +      L G G +PA+A+P
Sbjct: 890 VASKLCEETPITSVPRGSLRGRGPSPAAASP 920


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,547,794
Number of Sequences: 37866
Number of extensions: 4588763
Number of successful extensions: 45742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 421
Number of HSP's successfully gapped in prelim test: 2008
Number of HSP's that attempted gapping in prelim test: 22904
Number of HSP's gapped (non-prelim): 15736
length of query: 1126
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1013
effective length of database: 13,968,660
effective search space: 14150252580
effective search space used: 14150252580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.