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Search of human proteins with 23510384
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
(707 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens] 1486 0.0
gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens] 1457 0.0
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens] 933 0.0
gi|210032580 SET domain containing 1B [Homo sapiens] 102 1e-21
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 100 4e-21
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens] 100 8e-21
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 98 2e-20
gi|197313748 SET domain containing 2 [Homo sapiens] 98 3e-20
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 98 3e-20
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 98 3e-20
gi|55741677 SET domain containing 1A [Homo sapiens] 97 4e-20
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 95 3e-19
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 95 3e-19
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 95 3e-19
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor... 95 3e-19
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens] 94 3e-19
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens] 94 4e-19
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 94 6e-19
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 93 1e-18
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 91 3e-18
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 89 2e-17
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 89 2e-17
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 81 3e-15
gi|194306650 SET domain and mariner transposase fusion [Homo sap... 73 8e-13
gi|45356743 SET domain-containing 8 [Homo sapiens] 64 4e-10
gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens] 49 1e-05
gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens] 49 1e-05
gi|238624099 SET domain, bifurcated 2 isoform b [Homo sapiens] 47 6e-05
gi|238624095 SET domain, bifurcated 2 isoform a [Homo sapiens] 47 6e-05
gi|122937492 SET domain containing 5 [Homo sapiens] 42 0.003
>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
Length = 707
Score = 1486 bits (3847), Expect = 0.0
Identities = 707/707 (100%), Positives = 707/707 (100%)
Query: 1 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW 60
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
Sbjct: 1 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW 60
Query: 61 KQRRIQPVHILTSVSSLRGTREVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHG 120
KQRRIQPVHILTSVSSLRGTREVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHG
Sbjct: 61 KQRRIQPVHILTSVSSLRGTREVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHG 120
Query: 121 DRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFP 180
DRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFP
Sbjct: 121 DRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFP 180
Query: 181 SDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLH 240
SDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLH
Sbjct: 181 SDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLH 240
Query: 241 SFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALT 300
SFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALT
Sbjct: 241 SFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALT 300
Query: 301 AERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEE 360
AERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEE
Sbjct: 301 AERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEE 360
Query: 361 KKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIG 420
KKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIG
Sbjct: 361 KKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIG 420
Query: 421 TKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYN 480
TKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYN
Sbjct: 421 TKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYN 480
Query: 481 YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRE 540
YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRE
Sbjct: 481 YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRE 540
Query: 541 CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFIS 600
CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFIS
Sbjct: 541 CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFIS 600
Query: 601 EYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKV 660
EYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKV
Sbjct: 601 EYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKV 660
Query: 661 MMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP 707
MMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Sbjct: 661 MMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP 707
>gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens]
Length = 751
Score = 1457 bits (3773), Expect = 0.0
Identities = 706/751 (94%), Positives = 706/751 (94%), Gaps = 44/751 (5%)
Query: 1 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW 60
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
Sbjct: 1 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW 60
Query: 61 KQRRIQPVHILTSVSSLRGTRE-------------------------------------- 82
KQRRIQPVHILTSVSSLRGTRE
Sbjct: 61 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF 120
Query: 83 -VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ 141
VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
Sbjct: 121 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ 180
Query: 142 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL 201
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
Sbjct: 181 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL 240
Query: 202 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH--- 258
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH
Sbjct: 241 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC 300
Query: 259 --PFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR 316
FHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
Sbjct: 301 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR 360
Query: 317 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ 376
GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
Sbjct: 361 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ 420
Query: 377 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS 436
TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
Sbjct: 421 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS 480
Query: 437 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP 496
IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
Sbjct: 481 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP 540
Query: 497 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD 556
CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
Sbjct: 541 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD 600
Query: 557 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG 616
SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
Sbjct: 601 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG 660
Query: 617 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA 676
KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
Sbjct: 661 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA 720
Query: 677 IQTGEELFFDYRYSQADALKYVGIEREMEIP 707
IQTGEELFFDYRYSQADALKYVGIEREMEIP
Sbjct: 721 IQTGEELFFDYRYSQADALKYVGIEREMEIP 751
>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
Length = 747
Score = 933 bits (2411), Expect = 0.0
Identities = 466/754 (61%), Positives = 551/754 (73%), Gaps = 84/754 (11%)
Query: 15 WRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVH----- 69
W+++VKSEYMRLRQLKR + K+++ +N K+ E+T+ILN+EWK+ R+QPV
Sbjct: 15 WKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPV 74
Query: 70 -----------------------------------ILTSVSSLRGTREVEDETVLHNIPY 94
I+ S S L+ VEDETVL NIPY
Sbjct: 75 SGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPY 134
Query: 95 MGDEVLDQDGTFIEELIKNYDGKVHGDREC----GFINDEIFVELVNALGQYNDDDDDDD 150
MGDEV ++D TFIEELI NYDGKVHG+ E I+D +F+ELV+AL QY+D++++
Sbjct: 135 MGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGH 194
Query: 151 GDDPEEREEKQK-DLEDHRDDK-------ESRPPRKFPSDKIFEAISSMFPDKGTAEELK 202
D + +++ K DL R K + ++FP+D IF AI+SMFP+ G +++K
Sbjct: 195 NDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMK 254
Query: 203 EKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA 262
E+Y+ELTE P ALPP+CTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA
Sbjct: 255 ERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA 314
Query: 263 TPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNN 322
TPN YKRKN E ++ +PCG C+ LEGAKE+A + P + GRRR R
Sbjct: 315 TPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM------LHNPRSKCSGRRRRRHHIV 368
Query: 323 SSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM 381
S+ S + + V E+K+ DSDR+ G D SSSSEANSRCQTP K
Sbjct: 369 SASCSNASASAVAETKEGDSDRDTGN---------------DWASSSSEANSRCQTPTKQ 413
Query: 382 KPNIEPP---------ENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRV 432
K + PP E VEW+GAE S+FRV GTY++NFC+IARL+GTKTC+QV++F V
Sbjct: 414 KASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAV 473
Query: 433 KESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCD 492
KES +I P +++ P +KKKRKHRLWAAHCRKIQLKKD SS VYNYQPCDHP +PCD
Sbjct: 474 KES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCD 532
Query: 493 SSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAA 552
S+CPC++ QNFCEKFCQC+ +CQNRFPGCRCK QCNTKQCPCYLAVRECDPDLCLTCGA+
Sbjct: 533 STCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGAS 592
Query: 553 DHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEA 612
+HWD K VSCKNCSIQRG KKHLLLAPSDVAGWG FIK+ VQKNEFISEYCGE+ISQDEA
Sbjct: 593 EHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEA 652
Query: 613 DRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIF 672
DRRGKVYDKYM SFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKV+MVNGDHRIGIF
Sbjct: 653 DRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIF 712
Query: 673 AKRAIQTGEELFFDYRYSQADALKYVGIEREMEI 706
AKRAIQ GEELFFDYRYSQADALKYVGIERE ++
Sbjct: 713 AKRAIQAGEELFFDYRYSQADALKYVGIERETDV 746
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 102 bits (254), Expect = 1e-21
Identities = 50/124 (40%), Positives = 75/124 (60%), Gaps = 2/124 (1%)
Query: 572 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK--YMCSFLFN 629
KK L S + WG+F +P+ +E + EY G+ I Q AD R K Y+ S++F
Sbjct: 1783 KKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFR 1842
Query: 630 LNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 689
+++D ++DAT+ GN RF NHS NPNCYAKV+ V +I I++K+ I EE+ +DY++
Sbjct: 1843 VDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKF 1902
Query: 690 SQAD 693
D
Sbjct: 1903 PIED 1906
Score = 30.4 bits (67), Expect = 5.9
Identities = 10/23 (43%), Positives = 18/23 (78%)
Query: 144 DDDDDDDGDDPEEREEKQKDLED 166
++++DDD DD ++R+E + D ED
Sbjct: 1058 EEEEDDDDDDSDDRDESENDDED 1080
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 100 bits (250), Expect = 4e-21
Identities = 51/129 (39%), Positives = 78/129 (60%), Gaps = 1/129 (0%)
Query: 567 IQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYD-KYMCS 625
+++ SK+ + + S + G G+F K + E + EY G +I + D+R K YD K +
Sbjct: 3823 LKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGC 3882
Query: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
++F +++ VVDAT GN RF NHS PNCY++V+ ++G I IFA R I GEEL +
Sbjct: 3883 YMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTY 3942
Query: 686 DYRYSQADA 694
DY++ DA
Sbjct: 3943 DYKFPIEDA 3951
>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
Length = 2964
Score = 99.8 bits (247), Expect = 8e-21
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 19/184 (10%)
Query: 508 CQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
C C + GC C + EC P+ C CG C N I
Sbjct: 2091 CNCKKPDDDTRKGC-------VDDCLNRMIFAECSPNTC-PCGE---------QCCNQRI 2133
Query: 568 QRGSKKHLLLA-PSDVAGWGIFIKDPVQKNEFISEYCGEIISQDE-ADRRGKVYDKYMCS 625
QR L ++ GWGI K+P++ +FI EY GE++S+ E +R + Y +
Sbjct: 2134 QRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH 2193
Query: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
+ NL++ V+D+ R GN+ RF NHS +PNC + VNG +RIG++A + + G EL +
Sbjct: 2194 YCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTY 2253
Query: 686 DYRY 689
DY +
Sbjct: 2254 DYNF 2257
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 98.2 bits (243), Expect = 2e-20
Identities = 55/134 (41%), Positives = 79/134 (58%), Gaps = 8/134 (5%)
Query: 562 CKNCSIQRGSKKHL-LLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYD 620
C N +Q+G + L + D GWG+ + ++KN F+ EY GEII+ +EA+RRG++YD
Sbjct: 232 CPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYD 291
Query: 621 KYMCSFLFNLN---NDFVVDATRKGNKIRFANHSVNPNCYA-KVMMVNGDH---RIGIFA 673
+ ++LF+L+ + + VDA GN F NHS +PN V + N D RI FA
Sbjct: 292 RQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFA 351
Query: 674 KRAIQTGEELFFDY 687
R I+ GEEL FDY
Sbjct: 352 TRTIRAGEELTFDY 365
>gi|197313748 SET domain containing 2 [Homo sapiens]
Length = 2564
Score = 97.8 bits (242), Expect = 3e-20
Identities = 48/132 (36%), Positives = 71/132 (53%), Gaps = 2/132 (1%)
Query: 562 CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY-- 619
C N QR + + ++ GWG+ + N F+ EYCGE++ E R K Y
Sbjct: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
Query: 620 DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT 679
+K + + L ND ++DAT+KGN RF NHS PNC + VNG R+G F + + +
Sbjct: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
Query: 680 GEELFFDYRYSQ 691
G EL FDY++ +
Sbjct: 1659 GSELTFDYQFQR 1670
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 97.8 bits (242), Expect = 3e-20
Identities = 57/182 (31%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CKA T + PC + + EC P +C G C+N
Sbjct: 1621 SEIPRCNCKA---TDENPCGIDSECINRMLLYECHPTVCPAGGR----------CQNQCF 1667
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-- 625
+ + + + GWG+ K ++K EF++EY GE+I ++E R + ++ +
Sbjct: 1668 SKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNF 1727
Query: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
++ L+ D ++DA KGN RF NH PNC + VNGD R+G+FA I+ G EL F
Sbjct: 1728 YMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTF 1787
Query: 686 DY 687
+Y
Sbjct: 1788 NY 1789
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 97.8 bits (242), Expect = 3e-20
Identities = 57/182 (31%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CKA T + PC + + EC P +C G C+N
Sbjct: 1890 SEIPRCNCKA---TDENPCGIDSECINRMLLYECHPTVCPAGGR----------CQNQCF 1936
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-- 625
+ + + + GWG+ K ++K EF++EY GE+I ++E R + ++ +
Sbjct: 1937 SKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNF 1996
Query: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
++ L+ D ++DA KGN RF NH PNC + VNGD R+G+FA I+ G EL F
Sbjct: 1997 YMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTF 2056
Query: 686 DY 687
+Y
Sbjct: 2057 NY 2058
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 97.4 bits (241), Expect = 4e-20
Identities = 48/124 (38%), Positives = 73/124 (58%), Gaps = 2/124 (1%)
Query: 572 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFLFN 629
KK L S + WG+F +P+ +E + EY G+ I Q AD R K Y + S+LF
Sbjct: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
Query: 630 LNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 689
+++D ++DAT+ GN RF NH PNCYAKV+ + +I I++K+ I EE+ +DY++
Sbjct: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
Query: 690 SQAD 693
D
Sbjct: 1687 PLED 1690
Score = 35.4 bits (80), Expect = 0.18
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 13/78 (16%)
Query: 304 IKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDT-------------DSDREAGTETG 350
+K P P R +P ++ S+P VLE+ + RE G E G
Sbjct: 1306 VKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEG 1365
Query: 351 GENNDKEEEEKKDETSSS 368
E ++EEEE D +SSS
Sbjct: 1366 EEEGEEEEEESSDSSSSS 1383
Score = 30.4 bits (67), Expect = 5.9
Identities = 28/137 (20%), Positives = 46/137 (33%), Gaps = 24/137 (17%)
Query: 116 GKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREE---------KQKDLED 166
GK G F D E D++DD++ ++ E+REE + D ED
Sbjct: 949 GKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGED 1008
Query: 167 HRDDKESR---------------PPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQ 211
D S+ S + SS ++ + ++ E+
Sbjct: 1009 EESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEE 1068
Query: 212 QLPGALPPECTPNIDGP 228
+ P ALP P + P
Sbjct: 1069 ERPAALPSASPPPREVP 1085
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/182 (31%), Positives = 86/182 (47%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CK T + PC + + EC P +C C+N
Sbjct: 1011 SEIPKCNCKP---TDENPCGFDSECLNRMLMFECHPQVC----------PAGEFCQNQCF 1057
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF 626
+ + +D GWG+ K ++K EF++EY GE+I ++E R K ++ + F
Sbjct: 1058 TKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHF 1117
Query: 627 -LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
+ ++ D ++DA KGN RF NHS PNC VNGD R+G+FA I G EL F
Sbjct: 1118 YMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTF 1177
Query: 686 DY 687
+Y
Sbjct: 1178 NY 1179
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/182 (31%), Positives = 86/182 (47%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CK T + PC + + EC P +C C+N
Sbjct: 1011 SEIPKCNCKP---TDENPCGFDSECLNRMLMFECHPQVC----------PAGEFCQNQCF 1057
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF 626
+ + +D GWG+ K ++K EF++EY GE+I ++E R K ++ + F
Sbjct: 1058 TKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHF 1117
Query: 627 -LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
+ ++ D ++DA KGN RF NHS PNC VNGD R+G+FA I G EL F
Sbjct: 1118 YMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTF 1177
Query: 686 DY 687
+Y
Sbjct: 1178 NY 1179
>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/182 (31%), Positives = 86/182 (47%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CK T + PC + + EC P +C C+N
Sbjct: 1011 SEIPKCNCKP---TDENPCGFDSECLNRMLMFECHPQVC----------PAGEFCQNQCF 1057
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF 626
+ + +D GWG+ K ++K EF++EY GE+I ++E R K ++ + F
Sbjct: 1058 TKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHF 1117
Query: 627 -LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
+ ++ D ++DA KGN RF NHS PNC VNGD R+G+FA I G EL F
Sbjct: 1118 YMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTF 1177
Query: 686 DY 687
+Y
Sbjct: 1178 NY 1179
>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/182 (31%), Positives = 86/182 (47%), Gaps = 23/182 (12%)
Query: 516 NRFPGCRCKAQCNTKQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 567
+ P C CK T + PC + + EC P +C C+N
Sbjct: 1011 SEIPKCNCKP---TDENPCGFDSECLNRMLMFECHPQVC----------PAGEFCQNQCF 1057
Query: 568 QRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF 626
+ + +D GWG+ K ++K EF++EY GE+I ++E R K ++ + F
Sbjct: 1058 TKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHF 1117
Query: 627 -LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
+ ++ D ++DA KGN RF NHS PNC VNGD R+G+FA I G EL F
Sbjct: 1118 YMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTF 1177
Query: 686 DY 687
+Y
Sbjct: 1178 NY 1179
>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
Length = 1437
Score = 94.4 bits (233), Expect = 3e-19
Identities = 59/179 (32%), Positives = 89/179 (49%), Gaps = 17/179 (9%)
Query: 516 NRFPGCRCKAQ----CNTK-QCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRG 570
+ P C CK C + +C + EC P +C A D C+N +
Sbjct: 1093 SEIPRCNCKPADENPCGLESECLNRMLQYECHPQVC---PAGDR-------CQNQCFTKR 1142
Query: 571 SKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF-LF 628
+ ++ GWG+ K ++K EF++EY GE+I ++E R K ++ + +F +
Sbjct: 1143 LYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYML 1202
Query: 629 NLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 687
+ D ++DA KGN RF NHS NPNC + VNGD R+G+FA I G EL F+Y
Sbjct: 1203 TVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNY 1261
>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
Length = 350
Score = 94.0 bits (232), Expect = 4e-19
Identities = 53/135 (39%), Positives = 80/135 (59%), Gaps = 8/135 (5%)
Query: 562 CKNCSIQRGSKKHL-LLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYD 620
C N +Q+G++ L + S+ GWG+ +++ F+ EY GE+I+ +EA+RRG+ YD
Sbjct: 179 CPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYD 238
Query: 621 KYMCSFLFNL---NNDFVVDATRKGNKIRFANHSVNPNCYA-KVMMVNGD---HRIGIFA 673
++LF+L +++F VDA R GN F NHS +PN V + N D RI +F+
Sbjct: 239 NKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFS 298
Query: 674 KRAIQTGEELFFDYR 688
R I GEEL FDY+
Sbjct: 299 TRTINAGEELTFDYQ 313
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 93.6 bits (231), Expect = 6e-19
Identities = 51/129 (39%), Positives = 76/129 (58%), Gaps = 1/129 (0%)
Query: 567 IQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYD-KYMCS 625
+++ SK+ + + S + G G+F K + E + EY G +I D+R K YD K +
Sbjct: 2569 LKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGC 2628
Query: 626 FLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFF 685
++F +++ VVDAT GN RF NHS PNC+++V+ V G I IFA R I GEEL +
Sbjct: 2629 YMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTY 2688
Query: 686 DYRYSQADA 694
DY++ DA
Sbjct: 2689 DYKFPIEDA 2697
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 92.8 bits (229), Expect = 1e-18
Identities = 46/123 (37%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 572 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-FLFNL 630
K ++ LA S + G G++ ++K+ + EY G II + A+R+ K+Y+ ++F +
Sbjct: 4770 KSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRM 4829
Query: 631 NNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 690
+ND V+DAT G R+ NHS PNC A+V+ H+I I + R IQ GEEL +DY++
Sbjct: 4830 DNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFD 4889
Query: 691 QAD 693
D
Sbjct: 4890 FED 4892
Score = 30.8 bits (68), Expect = 4.5
Identities = 19/71 (26%), Positives = 28/71 (39%), Gaps = 10/71 (14%)
Query: 506 KFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVREC--------DPDLCLTCGAADHWDS 557
K+C C G RC+ Q N QC ++ C + DL L C D W
Sbjct: 1052 KWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQCRQCDRW-- 1109
Query: 558 KNVSCKNCSIQ 568
+ C+N + +
Sbjct: 1110 MHAVCQNLNTE 1120
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 91.3 bits (225), Expect = 3e-18
Identities = 45/123 (36%), Positives = 74/123 (60%), Gaps = 1/123 (0%)
Query: 572 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-FLFNL 630
K ++ LA S + G G++ ++K+ + EY G II + A+RR K+Y++ ++F +
Sbjct: 5396 KNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRI 5455
Query: 631 NNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 690
NN+ V+DAT G R+ NHS PNC A+V+ + + +I I + R I GEEL +DY++
Sbjct: 5456 NNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFD 5515
Query: 691 QAD 693
D
Sbjct: 5516 FED 5518
Score = 31.2 bits (69), Expect = 3.5
Identities = 21/73 (28%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 306 TPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDET 365
TP GG + +P++ +P TP +L S D DR + E + ++ KD
Sbjct: 1843 TPGPEDGGVKASPVPSDPEKPGTPGEGMLSS---DLDRISTEELPKMESKDLQQLFKDVL 1899
Query: 366 SSSSEANSRCQTP 378
S E + C TP
Sbjct: 1900 GSEREQHLGCGTP 1912
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
b [Homo sapiens]
Length = 1176
Score = 88.6 bits (218), Expect = 2e-17
Identities = 71/220 (32%), Positives = 100/220 (45%), Gaps = 38/220 (17%)
Query: 496 PCVIAQNFCEKFCQCSSECQNR----FPGCRCKAQCNTKQCPC-YLAVR----------- 539
PC + + C+ S+ +R C C C++ C C L++R
Sbjct: 911 PCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQ 970
Query: 540 ---ECDPDLCLTCG-AADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQK 595
+ +P L C A W + CKN +Q G K L L + GWG+ + +
Sbjct: 971 EFNKIEPPLIFECNQACSCWRN----CKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQ 1026
Query: 596 NEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNND----FVVDATRKGNKIRFANHS 651
FI EY GE+IS EAD R S+LF+L+N + +DA GN RF NH
Sbjct: 1027 GTFICEYVGELISDAEADVRED------DSYLFDLDNKDGEVYCIDARYYGNISRFINHL 1080
Query: 652 VNPNCY-AKVMMVNGD---HRIGIFAKRAIQTGEELFFDY 687
+PN +V M++ D RI F+ R I+TGEEL FDY
Sbjct: 1081 CDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY 1120
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
a [Homo sapiens]
Length = 1210
Score = 88.6 bits (218), Expect = 2e-17
Identities = 71/220 (32%), Positives = 100/220 (45%), Gaps = 38/220 (17%)
Query: 496 PCVIAQNFCEKFCQCSSECQNR----FPGCRCKAQCNTKQCPC-YLAVR----------- 539
PC + + C+ S+ +R C C C++ C C L++R
Sbjct: 945 PCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQ 1004
Query: 540 ---ECDPDLCLTCG-AADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQK 595
+ +P L C A W + CKN +Q G K L L + GWG+ + +
Sbjct: 1005 EFNKIEPPLIFECNQACSCWRN----CKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQ 1060
Query: 596 NEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNND----FVVDATRKGNKIRFANHS 651
FI EY GE+IS EAD R S+LF+L+N + +DA GN RF NH
Sbjct: 1061 GTFICEYVGELISDAEADVRED------DSYLFDLDNKDGEVYCIDARYYGNISRFINHL 1114
Query: 652 VNPNCY-AKVMMVNGD---HRIGIFAKRAIQTGEELFFDY 687
+PN +V M++ D RI F+ R I+TGEEL FDY
Sbjct: 1115 CDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY 1154
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/191 (31%), Positives = 83/191 (43%), Gaps = 34/191 (17%)
Query: 521 CRCKAQCNTKQCPCYLAVREC---------------DPDLCLTCG-AADHWDSKNVSCKN 564
C C C++ C C C +P L C A W + C+N
Sbjct: 1062 CVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRN----CRN 1117
Query: 565 CSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMC 624
+Q G + L L + GWG+ + F+ EY GE+IS EAD R +
Sbjct: 1118 RVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREE------D 1171
Query: 625 SFLFNLNND----FVVDATRKGNKIRFANHSVNPNCY-AKVMMVNGD---HRIGIFAKRA 676
S+LF+L+N + +DA GN RF NH PN +V M + D RI F+ R
Sbjct: 1172 SYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRL 1231
Query: 677 IQTGEELFFDY 687
I+ GE+L FDY
Sbjct: 1232 IEAGEQLGFDY 1242
>gi|194306650 SET domain and mariner transposase fusion [Homo
sapiens]
Length = 684
Score = 73.2 bits (178), Expect = 8e-13
Identities = 54/201 (26%), Positives = 82/201 (40%), Gaps = 35/201 (17%)
Query: 515 QNRFPGCRC-KAQCNTKQCPCYLAVRECDPDLCLT------------------CGAADHW 555
Q FPGC C K C C C D + CL C +DH
Sbjct: 69 QITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDH- 127
Query: 556 DSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRR 615
C+N +Q+G + H + + GWG+ + + K F+ EY GE++ E RR
Sbjct: 128 ------CRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRR 181
Query: 616 GKVYDKYMCSFLFNLNN--------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNG-D 666
+ K +++ + + VD T GN RF NHS PN + ++
Sbjct: 182 IHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMV 241
Query: 667 HRIGIFAKRAIQTGEELFFDY 687
++ +FA + I EEL +DY
Sbjct: 242 PKLALFAAKDIVPEEELSYDY 262
>gi|45356743 SET domain-containing 8 [Homo sapiens]
Length = 352
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/128 (31%), Positives = 67/128 (52%), Gaps = 8/128 (6%)
Query: 567 IQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK----- 621
I+ G ++ + + D G G+ + +F+ EY G++I +A +R +Y +
Sbjct: 210 IESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTG 269
Query: 622 -YMCSFLFNLNNDFVVDATRKGNKI-RFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT 679
YM F + L+ + VDATR+ N++ R NHS NC K+ ++G + + A R I
Sbjct: 270 CYMYYFQY-LSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAA 328
Query: 680 GEELFFDY 687
GEEL +DY
Sbjct: 329 GEELLYDY 336
>gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
Length = 1290
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/131 (27%), Positives = 51/131 (38%), Gaps = 27/131 (20%)
Query: 520 GCRCKAQCNTK-QCPC-----------------------YLAVRECDPDLCLTCGAADHW 555
GC CK C K +C C Y + EC P C
Sbjct: 728 GCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKC 787
Query: 556 DSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRR 615
D C N +Q G + L L + GWGI D + K F+ Y G+I++ D AD+
Sbjct: 788 DPN--MCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKE 845
Query: 616 G-KVYDKYMCS 625
G ++ D+Y +
Sbjct: 846 GLEMGDEYFAN 856
Score = 38.5 bits (88), Expect = 0.022
Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 5/60 (8%)
Query: 634 FVVDATRKGNKIRFANHSVNPNCYAKVMMVN-GDHR---IGIFAKRAIQTGEELFFDYRY 689
+++DA +GN R+ NHS +PN + + + V+ D R + FA + I+ G EL +DY Y
Sbjct: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNY 1266
>gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]
Length = 1291
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/131 (27%), Positives = 51/131 (38%), Gaps = 27/131 (20%)
Query: 520 GCRCKAQCNTK-QCPC-----------------------YLAVRECDPDLCLTCGAADHW 555
GC CK C K +C C Y + EC P C
Sbjct: 728 GCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKC 787
Query: 556 DSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRR 615
D C N +Q G + L L + GWGI D + K F+ Y G+I++ D AD+
Sbjct: 788 DPN--MCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKE 845
Query: 616 G-KVYDKYMCS 625
G ++ D+Y +
Sbjct: 846 GLEMGDEYFAN 856
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 4/60 (6%)
Query: 634 FVVDATRKGNKIRFANHSVNPNCYAKVMMVN-GDHR---IGIFAKRAIQTGEELFFDYRY 689
+++DA +GN R+ NHS +PN + + + V+ D R + FA + I+ G EL +DY Y
Sbjct: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNY 1267
>gi|238624099 SET domain, bifurcated 2 isoform b [Homo sapiens]
Length = 707
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 4/66 (6%)
Query: 628 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHR----IGIFAKRAIQTGEEL 683
FN N F++DAT++GN RF NHS PN + + V +R + F R ++ EL
Sbjct: 618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTEL 677
Query: 684 FFDYRY 689
+DY Y
Sbjct: 678 TWDYGY 683
Score = 35.4 bits (80), Expect = 0.18
Identities = 13/53 (24%), Positives = 28/53 (52%)
Query: 562 CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADR 614
C+N +Q G + L + ++ GWG+ D + + F+ Y G ++S+ ++
Sbjct: 344 CQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK 396
>gi|238624095 SET domain, bifurcated 2 isoform a [Homo sapiens]
Length = 719
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 4/66 (6%)
Query: 628 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHR----IGIFAKRAIQTGEEL 683
FN N F++DAT++GN RF NHS PN + + V +R + F R ++ EL
Sbjct: 630 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTEL 689
Query: 684 FFDYRY 689
+DY Y
Sbjct: 690 TWDYGY 695
Score = 35.4 bits (80), Expect = 0.18
Identities = 13/53 (24%), Positives = 28/53 (52%)
Query: 562 CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADR 614
C+N +Q G + L + ++ GWG+ D + + F+ Y G ++S+ ++
Sbjct: 356 CQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK 408
>gi|122937492 SET domain containing 5 [Homo sapiens]
Length = 1442
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 5/100 (5%)
Query: 599 ISEYCGEIISQDEADRRGKVYDKYMCSFLF--NLNN-DFVVDATRKGNKIRFANHSVNPN 655
I EY G+++ + + + G + K LF N + VDA GN RF S PN
Sbjct: 298 IIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPN 357
Query: 656 CYAKVMMVNGDHRIGIFAKRAIQTGEE--LFFDYRYSQAD 693
+ M+ +G + I+A AI E + FDY YS +
Sbjct: 358 AEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCN 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,029,571
Number of Sequences: 37866
Number of extensions: 1590048
Number of successful extensions: 13489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 219
Number of HSP's that attempted gapping in prelim test: 10748
Number of HSP's gapped (non-prelim): 2308
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.