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Search of human proteins with 116174754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116174754 phospholipase A2, group IVD [Homo sapiens]
(818 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116174754 phospholipase A2, group IVD [Homo sapiens] 1652 0.0
gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens] 766 0.0
gi|167860120 phospholipase A2, group IVB [Homo sapiens] 766 0.0
gi|122937428 phospholipase A2, group 4E [Homo sapiens] 672 0.0
gi|67972429 phospholipase A2, group IVF [Homo sapiens] 585 e-167
gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] 256 5e-68
gi|226693357 phospholipase A2, group IVC isoform 2 precursor [Ho... 180 4e-45
gi|226693363 phospholipase A2, group IVC isoform 3 [Homo sapiens] 179 7e-45
gi|226693354 phospholipase A2, group IVC isoform 1 precursor [Ho... 179 7e-45
gi|4506067 protein kinase C, alpha [Homo sapiens] 57 9e-08
gi|238550198 synaptotagmin III [Homo sapiens] 55 2e-07
gi|238550196 synaptotagmin III [Homo sapiens] 55 2e-07
gi|14150054 synaptotagmin III [Homo sapiens] 55 2e-07
gi|13384594 protein kinase C, gamma [Homo sapiens] 55 3e-07
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 54 6e-07
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 54 6e-07
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom... 54 6e-07
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 52 2e-06
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 52 2e-06
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 51 4e-06
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 51 4e-06
gi|103472031 family with sequence similarity 62 (C2 domain conta... 51 4e-06
gi|45387945 family with sequence similarity 62 (C2 domain contai... 51 4e-06
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 50 1e-05
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 50 1e-05
gi|211059429 synaptotagmin II [Homo sapiens] 49 1e-05
gi|31543670 synaptotagmin II [Homo sapiens] 49 1e-05
gi|222352090 neural precursor cell expressed, developmentally do... 49 2e-05
gi|222352088 neural precursor cell expressed, developmentally do... 49 2e-05
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 49 2e-05
>gi|116174754 phospholipase A2, group IVD [Homo sapiens]
Length = 818
Score = 1652 bits (4278), Expect = 0.0
Identities = 818/818 (100%), Positives = 818/818 (100%)
Query: 1 MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK 60
MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
Sbjct: 1 MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK 60
Query: 61 TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL 120
TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
Sbjct: 61 TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL 120
Query: 121 RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ 180
RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
Sbjct: 121 RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ 180
Query: 181 DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL 240
DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL
Sbjct: 181 DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL 240
Query: 241 TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV 300
TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV
Sbjct: 241 TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV 300
Query: 301 VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI 360
VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI
Sbjct: 301 VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI 360
Query: 361 SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH 420
SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH
Sbjct: 361 SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH 420
Query: 421 PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW 480
PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW
Sbjct: 421 PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW 480
Query: 481 VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY 540
VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY
Sbjct: 481 VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY 540
Query: 541 DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ 600
DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ
Sbjct: 541 DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ 600
Query: 601 RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF 660
RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF
Sbjct: 601 RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF 660
Query: 661 RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA 720
RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA
Sbjct: 661 RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA 720
Query: 721 CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER 780
CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER
Sbjct: 721 CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER 780
Query: 781 LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT 818
LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
Sbjct: 781 LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT 818
>gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens]
Length = 1012
Score = 766 bits (1979), Expect = 0.0
Identities = 403/797 (50%), Positives = 532/797 (66%), Gaps = 28/797 (3%)
Query: 15 QGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNE 74
+ E S LTVRVL+A L DL++ +D YV L L TA + +T+T+ ++S PVWN+
Sbjct: 234 KAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQ 293
Query: 75 AFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEEL 134
+F F I Q+KNV+EL ++D+D VT DD VL+D + G+ R++FS SPQGE L
Sbjct: 294 SFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRL 353
Query: 135 DVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLE--LELVLKGS 192
+VEF ++ +DR E L++N V+VARELSCL V L+ TG DQ E ++LV+ GS
Sbjct: 354 EVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETG------DQKSSEHRVQLVVPGS 407
Query: 193 YEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKE 252
E Q + +GT + FRFH A E ELS RL+ D L PL L G+
Sbjct: 408 CEGPQEASVGTGT-FRFHCPACWEQELSIRLQ---------DAPEEQLKAPLSALPSGQV 457
Query: 253 VTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLD 312
V + P P +R++LK E ELAV LGF CAEEQAFLSRRKQVVA AL+QALQLD
Sbjct: 458 VRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLD 517
Query: 313 RDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYG 372
DLQEDE+PVV IMATGGG RAMTSLYG L L++LGLLDCV+Y +G SGSTW +A+LY
Sbjct: 518 GDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYE 577
Query: 373 DPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVL 432
DPEWSQ+DL GP + + K+KL V +P +L YR+EL RA G+P+ F +LWAL+
Sbjct: 578 DPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALIN 637
Query: 433 ESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLK 492
E++LH + D KLS QR AL GQNPLP+Y +LN K +L T +F EW EFSPYEVGF K
Sbjct: 638 EALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPK 697
Query: 493 YGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQH 552
YGAF+P ELFGSEFFMG+LM+R+PE RICFLE IWSN+++ NL D+ Y + + W +
Sbjct: 698 YGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRW 757
Query: 553 IKDKTRSLEKEPLTTSGTSSRLEASWLQPGTA--LAQAFKGFLTGRPLHQRSPNFLQGLQ 610
++++ +L+KE + P TA +A+ F LT RPL Q + NFL+GL
Sbjct: 758 VRNQA-NLDKEQVPLLKIEE-------PPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLH 809
Query: 611 LHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLIL 670
H+DY H FSTW LD +P+QLTP EP LCL+D Y INTS + +P R +DLIL
Sbjct: 810 FHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLIL 869
Query: 671 SFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHF 730
S DY+L F+ LQ +C+ +G+PFP + PSP++Q QPRECH FSDP CP AP +LHF
Sbjct: 870 SLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHF 929
Query: 731 PLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQ 790
PLV+ SF+++SAPGV+R+P E G+V+L+ + PY + +TY +ED ++LL L+ YNV
Sbjct: 930 PLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVC 989
Query: 791 TSQGAILQALRTALKHR 807
+Q +L+ALR A++ R
Sbjct: 990 NNQEQLLEALRQAVQRR 1006
>gi|167860120 phospholipase A2, group IVB [Homo sapiens]
Length = 781
Score = 766 bits (1978), Expect = 0.0
Identities = 403/795 (50%), Positives = 531/795 (66%), Gaps = 28/795 (3%)
Query: 17 EASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAF 76
E S LTVRVL+A L DL++ +D YV L L TA + +T+T+ ++S PVWN++F
Sbjct: 5 EVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSF 64
Query: 77 RFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDV 136
F I Q+KNV+EL ++D+D VT DD VL+D + G+ R++FS SPQGE L+V
Sbjct: 65 HFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEV 124
Query: 137 EFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLE--LELVLKGSYE 194
EF ++ +DR E L++N V+VARELSCL V L+ TG DQ E ++LV+ GS E
Sbjct: 125 EFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETG------DQKSSEHRVQLVVPGSCE 178
Query: 195 DTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVT 254
Q + +GT + FRFH A E ELS RL+ D L PL L G+ V
Sbjct: 179 GPQEASVGTGT-FRFHCPACWEQELSIRLQ---------DAPEEQLKAPLSALPSGQVVR 228
Query: 255 MDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRD 314
+ P P +R++LK E ELAV LGF CAEEQAFLSRRKQVVA AL+QALQLD D
Sbjct: 229 LVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGD 288
Query: 315 LQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDP 374
LQEDE+PVV IMATGGG RAMTSLYG L L++LGLLDCV+Y +G SGSTW +A+LY DP
Sbjct: 289 LQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDP 348
Query: 375 EWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLES 434
EWSQ+DL GP + + K+KL V +P +L YR+EL RA G+P+ F +LWAL+ E+
Sbjct: 349 EWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEA 408
Query: 435 MLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYG 494
+LH + D KLS QR AL GQNPLP+Y +LN K +L T +F EW EFSPYEVGF KYG
Sbjct: 409 LLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYG 468
Query: 495 AFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIK 554
AF+P ELFGSEFFMG+LM+R+PE RICFLE IWSN+++ NL D+ Y + + W + ++
Sbjct: 469 AFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVR 528
Query: 555 DKTRSLEKEPLTTSGTSSRLEASWLQPGTA--LAQAFKGFLTGRPLHQRSPNFLQGLQLH 612
++ +L+KE + P TA +A+ F LT RPL Q + NFL+GL H
Sbjct: 529 NQA-NLDKEQVPLLKIEE-------PPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFH 580
Query: 613 QDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSF 672
+DY H FSTW LD +P+QLTP EP LCL+D Y INTS + +P R +DLILS
Sbjct: 581 KDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSL 640
Query: 673 DYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPL 732
DY+L F+ LQ +C+ +G+PFP + PSP++Q QPRECH FSDP CP AP +LHFPL
Sbjct: 641 DYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPL 700
Query: 733 VNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTS 792
V+ SF+++SAPGV+R+P E G+V+L+ + PY + +TY +ED ++LL L+ YNV +
Sbjct: 701 VSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNN 760
Query: 793 QGAILQALRTALKHR 807
Q +L+ALR A++ R
Sbjct: 761 QEQLLEALRQAVQRR 775
>gi|122937428 phospholipase A2, group 4E [Homo sapiens]
Length = 839
Score = 672 bits (1734), Expect = 0.0
Identities = 358/794 (45%), Positives = 510/794 (64%), Gaps = 31/794 (3%)
Query: 40 LSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVT 99
+S+ D +V L L TA K +T+T+++ +P WNE+F F IQS+VKNVLELS+ DED+VT
Sbjct: 57 VSQTDCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQIQSRVKNVLELSVCDEDTVT 116
Query: 100 EDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVAR 159
DD VLYD++++ K F +PQG EEL+VEFL+EE+ PE L+TN V+V+R
Sbjct: 117 PDDHLLTVLYDLTKLCFRKKTHVKFPLNPQGMEELEVEFLLEESPSPPETLVTNGVLVSR 176
Query: 160 ELSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQT------SFLGTASAFR----F 209
++SCL+VH S +D L +++ S+E+TQ T++ F+ F
Sbjct: 177 QVSCLEVHAQSRRRRKREKMKDLL---VMVNESFENTQRVRPCLEPCCPTSACFQTAACF 233
Query: 210 HYMAALETELSGRLRSSRSNGWN-----GDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPG 264
HY ++++ + S W+ G ++ PL L+ G+ +T+ P
Sbjct: 234 HYPKYFQSQVHVEVPKSH---WSCGLCCRSRKKGPISQPLDCLSDGQVMTL----PVGES 286
Query: 265 VRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVG 324
L +K+ CPE L V LGF+LC E FL +RK VVAKALKQ LQL+ DLQEDEVP++
Sbjct: 287 YELHMKSTPCPETLDVRLGFSLCPAELEFLQKRKVVVAKALKQVLQLEEDLQEDEVPLIA 346
Query: 325 IMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGP 384
IMATGGG R+MTS+YGHLL LQKL LLDC +Y +G+SG+TWTMA LY DP+WS ++LE
Sbjct: 347 IMATGGGTRSMTSMYGHLLGLQKLNLLDCASYITGLSGATWTMATLYRDPDWSSKNLEPA 406
Query: 385 IRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQK 444
I AR H+ K KL P++L ++ EL R+++G+ TF D W L++E+ L + + K
Sbjct: 407 IFEARRHVVKDKLPSLFPDQLRKFQEELRQRSQEGYRVTFTDFWGLLIETCLGDERNECK 466
Query: 445 LSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGS 504
LS QRAAL GQNPLP+YL++NVK+ ++ DF+EW EFSPYEVG KYGAF+P ELFGS
Sbjct: 467 LSDQRAALSCGQNPLPIYLTINVKD-DVSNQDFREWFEFSPYEVGLQKYGAFIPSELFGS 525
Query: 505 EFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEP 564
EFFMGRL++RIPE RIC++ +WS+IFSLNLLDAW +S E + + ++K + +E EP
Sbjct: 526 EFFMGRLVKRIPESRICYMLGLWSSIFSLNLLDAWNLSHTSEEFFHRWTREKVQDIEDEP 585
Query: 565 L---TTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDF 621
+ ++ LE + + PG+ L+ +F+ LT R NFL GLQLH +Y + F
Sbjct: 586 ILPEIPKCDANILETTVVIPGSWLSNSFREILTHRSFVSEFHNFLSGLQLHTNYLQNGQF 645
Query: 622 STWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFE 681
S W D LD P+QLT LCL+D A+F+N+S P + RP R+ DLI+ +Y + +
Sbjct: 646 SRWKDTVLDGFPNQLTESANHLCLLDTAFFVNSSYPPLLRPERKADLIIHLNYCAGSQTK 705
Query: 682 ALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDHS 741
L+QT YC + +PFP+ E P + +EC+L +P P+API+ FPL+N +F+ +
Sbjct: 706 PLKQTCEYCTVQNIPFPKYE-LPDENENLKECYLMENPQEPDAPIVTFFPLINDTFRKYK 764
Query: 742 APGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALR 801
APGV+RSP EL+ GQVD+ G PY +TY E F++L++LS+YN+ ++ +LQALR
Sbjct: 765 APGVERSPEELEQGQVDIYGPKTPYATKELTYTEATFDKLVKLSEYNILNNKDTLLQALR 824
Query: 802 TAL-KHRTLEARPP 814
A+ K + L+ + P
Sbjct: 825 LAVEKKKRLKGQCP 838
>gi|67972429 phospholipase A2, group IVF [Homo sapiens]
Length = 849
Score = 585 bits (1509), Expect = e-167
Identities = 340/820 (41%), Positives = 469/820 (57%), Gaps = 21/820 (2%)
Query: 8 GPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDT 67
GP ++ E + L V+VL A N+R DLLS+AD YV L L TA +T+ + +
Sbjct: 30 GPLWRHWRRETYPYYDLQVKVLRATNIRGTDLLSKADCYVQLWLPTASPSPAQTRIVANC 89
Query: 68 SHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQS 127
S P WNE F + I VKNVLEL++YD+D + D + +L+D+ + G+ + TF +
Sbjct: 90 SDPEWNETFHYQIHGAVKNVLELTLYDKDILGSDQLSL-LLFDLRSLKCGQPHKHTFPLN 148
Query: 128 PQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGS-TAVVADQDKLELE 186
Q +EL VEF++E++ +ITN V+VA CL + G TA + +L+
Sbjct: 149 HQDSQELQVEFVLEKSQVPASEVITNGVLVAHP--CLRIQGTLRGDGTAPREEYGSRQLQ 206
Query: 187 LVLKGSYEDTQTSFL------GTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSA--- 237
L + G+YE Q L G F FH L + L L + +G ++
Sbjct: 207 LAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEA 266
Query: 238 -----GYLTVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQA 292
G + L L +G+E V V L +K E +L + LGF+L EQ
Sbjct: 267 QTSKLGEGGILLSSLPLGQEEQCSVALGEGQEVALSMKVEMSSGDLDLRLGFDLSDGEQE 326
Query: 293 FLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLD 352
FL RRKQVV+KAL+Q L L L +VPVV ++ +GGG RAM+SLYG L LQ+LGLLD
Sbjct: 327 FLDRRKQVVSKALQQVLGLSEALDSGQVPVVAVLGSGGGTRAMSSLYGSLAGLQELGLLD 386
Query: 353 CVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRREL 412
VTY SG+SGSTW ++ LY DP WSQ L+GPI A+ H+ SK+ S ERL Y +EL
Sbjct: 387 TVTYLSGVSGSTWCISTLYRDPAWSQVALQGPIERAQVHVCSSKMGALSTERLQYYTQEL 446
Query: 413 ELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNL 472
+R GH + +DLW L++E +L+ + KLS Q+ A+ +GQNP P+Y S+NV+ NL
Sbjct: 447 GVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVR-TNL 505
Query: 473 ETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFS 532
DF EW EF+PYEVGF KYGA+VP ELFGSE FMGRL++ PEPRIC+L+ +W + F+
Sbjct: 506 SGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFA 565
Query: 533 LNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGF 592
+L + + SG S+ + + + SRL L P +QA
Sbjct: 566 TSLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQLHNPSRLRTRLLTPQGPFSQAVLDI 625
Query: 593 LTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFI 652
T R +S NF +GL LH+DY + ++F W D D+ P+QLTP L LVD + I
Sbjct: 626 FTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDTHPDAFPNQLTPMRDCLYLVDGGFAI 685
Query: 653 NTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRE 712
N+ P P R +DLILSFDYSL APFE L+ TE YC RG+PFP +E P+D + RE
Sbjct: 686 NSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTEKYCLDRGIPFPSIEVGPEDVEEARE 745
Query: 713 CHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQG-GQVDLTGATCPYTLSNM 771
C+LF+ P +PI+LHFPLVN +F+ H APGV+R AE + G + PY + N
Sbjct: 746 CYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFVINRPDTPYGMMNF 805
Query: 772 TYKEEDFERLLRLSDYNVQTSQGAILQALRTAL-KHRTLE 810
TY+ +DF RL+ LS YNV + + AL+ AL +H+ E
Sbjct: 806 TYEPQDFYRLVALSRYNVLNNVETLKCALQLALDRHQARE 845
>gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]
Length = 749
Score = 256 bits (655), Expect = 5e-68
Identities = 183/627 (29%), Positives = 310/627 (49%), Gaps = 59/627 (9%)
Query: 234 DNSAGYLTVPLRPLTIG--KEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQ 291
D + G T + + +G KEV + + L+ CP+ + LC +E+
Sbjct: 99 DETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPD---LRFSMALCDQEK 155
Query: 292 AFLSRRKQVVAKALKQALQLDRDL---QEDEVPVVGIMATGGGARAMTSLYGHLLALQKL 348
F +RK+ + +++K+ L +VPVV I+ +GGG RAM G + AL +
Sbjct: 156 TFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYES 215
Query: 349 GLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASY 408
G+LDC TY +G+SGSTW M+ LY P++ ++ E ++++ + L + +P+++ Y
Sbjct: 216 GILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRY 275
Query: 409 RRELELRAEQGHPTTFVDLWALVL-ESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNV 467
L + G P TF D++ +++ E+++H + M+ LS + + Q PLPL+ L+V
Sbjct: 276 VESLWKKKSSGQPVTFTDIFGMLIGETLIHNR-MNTTLSSLKEKVNTAQCPLPLFTCLHV 334
Query: 468 KENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIW 527
K ++ L F +WVEFSPYE+G KYG F+ P+LFGS+FFMG ++++ E + FL +W
Sbjct: 335 KP-DVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVW 393
Query: 528 SNIFSL--NLLDAWYDLTSSGESWKQHIKDKTR------------SLEKEPLTT------ 567
+ FS+ N + S G + ++ +++ T EP T
Sbjct: 394 GSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAG 453
Query: 568 SGTSSRLEASWL-QPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDY--CSHKDFSTW 624
S S +ASW+ + AL F T + NF+ GL L+ Y DF+T
Sbjct: 454 SDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQ 513
Query: 625 ADYQLDSMPS-------------QLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILS 671
+ D + + L K ++ +VD+ N P + RP R +DLI+S
Sbjct: 514 DSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIIS 573
Query: 672 FDYSL-----SAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACP---- 722
FD+S S PF+ L E + + LPFP+++P D+ +EC++F P P
Sbjct: 574 FDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK-PKNPDMEK 632
Query: 723 EAPILLHFPLVNASFKDHSAPGVQR-SPAELQGGQVDL-TGATCPYTLSNMTYKEEDFER 780
+ P ++HF L N +F+ + APGV R + E + D+ P++ N Y + F+R
Sbjct: 633 DCPTIIHFVLANINFRKYKAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKR 692
Query: 781 LLRLSDYNVQTSQGAILQALRTALKHR 807
L L +N + I +A+ ++++R
Sbjct: 693 LHDLMHFNTLNNIDVIKEAMVESIEYR 719
Score = 58.9 bits (141), Expect = 2e-08
Identities = 33/97 (34%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 13 PYQG---EASTCWQLTVRVLEARNLR---WADLLSEADPYVILQLSTAPGMKFKTKTLTD 66
PYQ E + TV VL A + + D+L DPYV L +ST P + +T+ +
Sbjct: 6 PYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNN 65
Query: 67 TSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDI 103
+PVWNE F F++ +NVLE+++ D + V ++ +
Sbjct: 66 DINPVWNETFEFILDPNQENVLEITLMDANYVMDETL 102
>gi|226693357 phospholipase A2, group IVC isoform 2 precursor [Homo
sapiens]
Length = 551
Score = 180 bits (457), Expect = 4e-45
Identities = 157/558 (28%), Positives = 244/558 (43%), Gaps = 79/558 (14%)
Query: 279 AVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSL 338
AVH G EE+A + RR+ V KALK+ ++ DE PVV ++ +GGG RA +
Sbjct: 18 AVHHGKK---EEKAAVERRRLHVLKALKKLR-----IEADEAPVVAVLGSGGGLRAHIAC 69
Query: 339 YGHLLALQKLGLLDCVTYFSGISGSTWTMAHLY---GDPEWSQRDLEGPIRYAREHLAKS 395
G L +++ GLLD VTY +G+SGSTW ++ LY GD E + DL+ LAKS
Sbjct: 70 LGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKS 129
Query: 396 KLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERG 455
+ R +Y + D WA ++ S ++ + LS + +E G
Sbjct: 130 LQKTIQAARSENY--------------SLTDFWAYMVISKQTRELPESHLSNMKKPVEEG 175
Query: 456 QNPLPLYLSL--NVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMR 513
P P++ ++ +++ + E + W EF+P+ GF GAFV FGS+F GRL+R
Sbjct: 176 TLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVR 235
Query: 514 RIPEPRICFLEAIW------SNIFSLNLLDAWYDLTSSGESWKQHIKDK----------- 556
PE + FL +W + + + D +LT G W++ + +
Sbjct: 236 THPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKG-LWRRAVANAKSIGHLIFARL 294
Query: 557 ---TRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQ 613
S + E E +WL L + L + P L
Sbjct: 295 LRLQESSQGEHPPPEDEGGEPEHTWLT--EMLENWTRTSLEKQEQPHEDPERKGSLSNLM 352
Query: 614 DY------CSHK-DFSTWAD--YQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGR 664
D+ C+ K ++ T + Y+ + ++ L LVDA INT P + P R
Sbjct: 353 DFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTR 412
Query: 665 RLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQD--QHQPRECHLFSDPACP 722
+ LILSFD+S PFE ++ T YCR +PFP+VE + D P C++
Sbjct: 413 EVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGET-- 470
Query: 723 EAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLL 782
P+++HFPL N + GG ++ T TY + LL
Sbjct: 471 -GPVVMHFPLFN---------------IDACGGDIEAWSDTYDTFKLADTYTLDVVVLLL 514
Query: 783 RLSDYNVQTSQGAILQAL 800
L+ NV+ ++ IL+ L
Sbjct: 515 ALAKKNVRENKKKILREL 532
>gi|226693363 phospholipase A2, group IVC isoform 3 [Homo sapiens]
Length = 527
Score = 179 bits (455), Expect = 7e-45
Identities = 153/548 (27%), Positives = 240/548 (43%), Gaps = 76/548 (13%)
Query: 289 EEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKL 348
EE+A + RR+ V KALK+ ++ DE PVV ++ +GGG RA + G L +++
Sbjct: 15 EEKAAVERRRLHVLKALKKLR-----IEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQ 69
Query: 349 GLLDCVTYFSGISGSTWTMAHLY---GDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERL 405
GLLD VTY +G+SGSTW ++ LY GD E + DL+ LAKS + R
Sbjct: 70 GLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARS 129
Query: 406 ASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSL 465
+Y + D WA ++ S ++ + LS + +E G P P++ ++
Sbjct: 130 ENY--------------SLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAI 175
Query: 466 --NVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFL 523
+++ + E + W EF+P+ GF GAFV FGS+F GRL+R PE + FL
Sbjct: 176 DNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFL 235
Query: 524 EAIW------SNIFSLNLLDAWYDLTSSGESWKQHIKDK--------------TRSLEKE 563
+W + + + D +LT G W++ + + S + E
Sbjct: 236 RGLWGSALGNTEVIREYIFDQLRNLTLKG-LWRRAVANAKSIGHLIFARLLRLQESSQGE 294
Query: 564 PLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDY------CS 617
E +WL L + L + P L D+ C+
Sbjct: 295 HPPPEDEGGEPEHTWLT--EMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICA 352
Query: 618 HK-DFSTWAD--YQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDY 674
K ++ T + Y+ + ++ L LVDA INT P + P R + LILSFD+
Sbjct: 353 SKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDF 412
Query: 675 SLSAPFEALQQTELYCRARGLPFPRVEPSPQD--QHQPRECHLFSDPACPEAPILLHFPL 732
S PFE ++ T YCR +PFP+VE + D P C++ P+++HFPL
Sbjct: 413 SAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGET---GPVVMHFPL 469
Query: 733 VNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTS 792
N + GG ++ T TY + LL L+ NV+ +
Sbjct: 470 FN---------------IDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVREN 514
Query: 793 QGAILQAL 800
+ IL+ L
Sbjct: 515 KKKILREL 522
>gi|226693354 phospholipase A2, group IVC isoform 1 precursor [Homo
sapiens]
Length = 541
Score = 179 bits (455), Expect = 7e-45
Identities = 153/548 (27%), Positives = 240/548 (43%), Gaps = 76/548 (13%)
Query: 289 EEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKL 348
EE+A + RR+ V KALK+ ++ DE PVV ++ +GGG RA + G L +++
Sbjct: 15 EEKAAVERRRLHVLKALKKLR-----IEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQ 69
Query: 349 GLLDCVTYFSGISGSTWTMAHLY---GDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERL 405
GLLD VTY +G+SGSTW ++ LY GD E + DL+ LAKS + R
Sbjct: 70 GLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARS 129
Query: 406 ASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSL 465
+Y + D WA ++ S ++ + LS + +E G P P++ ++
Sbjct: 130 ENY--------------SLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAI 175
Query: 466 --NVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFL 523
+++ + E + W EF+P+ GF GAFV FGS+F GRL+R PE + FL
Sbjct: 176 DNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFL 235
Query: 524 EAIW------SNIFSLNLLDAWYDLTSSGESWKQHIKDK--------------TRSLEKE 563
+W + + + D +LT G W++ + + S + E
Sbjct: 236 RGLWGSALGNTEVIREYIFDQLRNLTLKG-LWRRAVANAKSIGHLIFARLLRLQESSQGE 294
Query: 564 PLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDY------CS 617
E +WL L + L + P L D+ C+
Sbjct: 295 HPPPEDEGGEPEHTWLT--EMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICA 352
Query: 618 HK-DFSTWAD--YQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDY 674
K ++ T + Y+ + ++ L LVDA INT P + P R + LILSFD+
Sbjct: 353 SKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDF 412
Query: 675 SLSAPFEALQQTELYCRARGLPFPRVEPSPQD--QHQPRECHLFSDPACPEAPILLHFPL 732
S PFE ++ T YCR +PFP+VE + D P C++ P+++HFPL
Sbjct: 413 SAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGET---GPVVMHFPL 469
Query: 733 VNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTS 792
N + GG ++ T TY + LL L+ NV+ +
Sbjct: 470 FN---------------IDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVREN 514
Query: 793 QGAILQAL 800
+ IL+ L
Sbjct: 515 KKKILREL 522
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 56.6 bits (135), Expect = 9e-08
Identities = 43/129 (33%), Positives = 67/129 (51%), Gaps = 14/129 (10%)
Query: 23 QLTVRVLEARNLRWADLLSEADPYVILQLSTAPG--MKFKTKTLTDTSHPVWNEAFRFLI 80
+L V V +A+NL D +DPYV L+L P K KTKT+ T +P WNE+F F +
Sbjct: 172 KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKL 231
Query: 81 QSQVKN-VLELSIYDEDSVTEDDICFKVLYDISEV--LPGKLLRKTFSQS---------P 128
+ K+ L + I+D D T +D + + +SE+ +P K +Q P
Sbjct: 232 KPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIP 291
Query: 129 QGEEELDVE 137
+G+EE ++E
Sbjct: 292 EGDEEGNME 300
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/180 (28%), Positives = 79/180 (43%), Gaps = 22/180 (12%)
Query: 7 GGPPGHPYQGEASTCW-------------QLTVRVLEARNLRWADLLSEADPYVILQLST 53
GG PG G + C QL VR+L+A +L D +DPYV + L
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLP 345
Query: 54 APGMKFKTKTLTDTSHPVWNEAFRFLI--QSQVKNVLELSIYDEDSVTEDDICFKVLYD- 110
KF+TK T +PV+NE F+F + + L S+YD D + D+ +V+ D
Sbjct: 346 DRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDN 405
Query: 111 ---ISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRP-ENLITNKVIVARELSCLDV 166
++E P + L + + G E+ D+ L P +T +I A L +D+
Sbjct: 406 LLELAEQPPDRPLWRDIVEG--GSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDL 463
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 20 TCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPG--MKFKTKTLTDTSHPVWNEAFR 77
T +LTV +++A NL+ DL +DPYV L + K KT +T +P +NEA
Sbjct: 444 TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV 503
Query: 78 F-LIQSQVKNV-LELSIYDEDSVTEDDI 103
F + V+NV L +++ D D + +++
Sbjct: 504 FDVAPESVENVGLSIAVVDYDCIGHNEV 531
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/180 (28%), Positives = 79/180 (43%), Gaps = 22/180 (12%)
Query: 7 GGPPGHPYQGEASTCW-------------QLTVRVLEARNLRWADLLSEADPYVILQLST 53
GG PG G + C QL VR+L+A +L D +DPYV + L
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLP 345
Query: 54 APGMKFKTKTLTDTSHPVWNEAFRFLI--QSQVKNVLELSIYDEDSVTEDDICFKVLYD- 110
KF+TK T +PV+NE F+F + + L S+YD D + D+ +V+ D
Sbjct: 346 DRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDN 405
Query: 111 ---ISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRP-ENLITNKVIVARELSCLDV 166
++E P + L + + G E+ D+ L P +T +I A L +D+
Sbjct: 406 LLELAEQPPDRPLWRDIVEG--GSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDL 463
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 20 TCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPG--MKFKTKTLTDTSHPVWNEAFR 77
T +LTV +++A NL+ DL +DPYV L + K KT +T +P +NEA
Sbjct: 444 TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV 503
Query: 78 F-LIQSQVKNV-LELSIYDEDSVTEDDI 103
F + V+NV L +++ D D + +++
Sbjct: 504 FDVAPESVENVGLSIAVVDYDCIGHNEV 531
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/180 (28%), Positives = 79/180 (43%), Gaps = 22/180 (12%)
Query: 7 GGPPGHPYQGEASTCW-------------QLTVRVLEARNLRWADLLSEADPYVILQLST 53
GG PG G + C QL VR+L+A +L D +DPYV + L
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLP 345
Query: 54 APGMKFKTKTLTDTSHPVWNEAFRFLI--QSQVKNVLELSIYDEDSVTEDDICFKVLYD- 110
KF+TK T +PV+NE F+F + + L S+YD D + D+ +V+ D
Sbjct: 346 DRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDN 405
Query: 111 ---ISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRP-ENLITNKVIVARELSCLDV 166
++E P + L + + G E+ D+ L P +T +I A L +D+
Sbjct: 406 LLELAEQPPDRPLWRDIVEG--GSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDL 463
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 20 TCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPG--MKFKTKTLTDTSHPVWNEAFR 77
T +LTV +++A NL+ DL +DPYV L + K KT +T +P +NEA
Sbjct: 444 TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV 503
Query: 78 F-LIQSQVKNV-LELSIYDEDSVTEDDI 103
F + V+NV L +++ D D + +++
Sbjct: 504 FDVAPESVENVGLSIAVVDYDCIGHNEV 531
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/101 (37%), Positives = 55/101 (54%), Gaps = 3/101 (2%)
Query: 18 ASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPG--MKFKTKTLTDTSHPVWNEA 75
A T ++ V V EARNL D +DPYV L+L P K KT+T+ T +PVWNE
Sbjct: 167 APTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNET 226
Query: 76 FRF-LIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVL 115
F F L V+ L + ++D D + +D + + +SE+L
Sbjct: 227 FVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELL 267
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/121 (28%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L V+VL+A +L AD ++DP+ +L+L + +T T+ +P WN+ F F I+
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFPIKD- 566
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGK-----LLRKTFSQSPQGEEELDVEF 138
+ +VLE++++DED D KV + + G+ L K Q+ +G L+++
Sbjct: 567 IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 626
Query: 139 L 139
+
Sbjct: 627 I 627
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
LT+ + E RNL D +DPYV +L+ +K+K + +PVW+E IQS
Sbjct: 196 LTIHLKEGRNLVVRDRCGTSDPYVKFKLNGK--TLYKSKVIYKNLNPVWDEIVVLPIQS- 252
Query: 84 VKNVLELSIYDEDSVTEDDI--CFKVLYDI 111
+ L + +YD D T D + F +L D+
Sbjct: 253 LDQKLRVKVYDRDLTTSDFMGSAFVILSDL 282
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/89 (23%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
+++ +LE +N+ + + +V L+L ++K+KTL +++P W E F F S
Sbjct: 358 ISITLLEGKNVSGGSM---TEMFVQLKLGD---QRYKSKTLCKSANPQWQEQFDFHYFSD 411
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDIS 112
+L++ ++ +D+ ++ DIS
Sbjct: 412 RMGILDIEVWGKDNKKHEERLGTCKVDIS 440
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/121 (28%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L V+VL+A +L AD ++DP+ +L+L + +T T+ +P WN+ F F I+
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFPIKD- 566
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGK-----LLRKTFSQSPQGEEELDVEF 138
+ +VLE++++DED D KV + + G+ L K Q+ +G L+++
Sbjct: 567 IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 626
Query: 139 L 139
+
Sbjct: 627 I 627
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
LT+ + E RNL D +DPYV +L+ +K+K + +PVW+E IQS
Sbjct: 196 LTIHLKEGRNLVVRDRCGTSDPYVKFKLNGK--TLYKSKVIYKNLNPVWDEIVVLPIQS- 252
Query: 84 VKNVLELSIYDEDSVTEDDI--CFKVLYDI 111
+ L + +YD D T D + F +L D+
Sbjct: 253 LDQKLRVKVYDRDLTTSDFMGSAFVILSDL 282
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/89 (23%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
+++ +LE +N+ + + +V L+L ++K+KTL +++P W E F F S
Sbjct: 358 ISITLLEGKNVSGGSM---TEMFVQLKLGD---QRYKSKTLCKSANPQWQEQFDFHYFSD 411
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDIS 112
+L++ ++ +D+ ++ DIS
Sbjct: 412 RMGILDIEVWGKDNKKHEERLGTCKVDIS 440
>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
sapiens]
Length = 306
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/121 (28%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L V+VL+A +L AD ++DP+ +L+L + +T T+ +P WN+ F F I+
Sbjct: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFPIKD- 154
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGK-----LLRKTFSQSPQGEEELDVEF 138
+ +VLE++++DED D KV + + G+ L K Q+ +G L+++
Sbjct: 155 IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 214
Query: 139 L 139
+
Sbjct: 215 I 215
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/95 (30%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L V+V+ A L AD+ ++DP+ +++L+ + T T+ +P WN+ F F I+
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNND---RLLTHTVYKNLNPEWNKVFTFNIK-D 462
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGK 118
+ +VLE+++YDED D KV + + G+
Sbjct: 463 IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGE 497
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/111 (27%), Positives = 57/111 (51%), Gaps = 4/111 (3%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
+++ ++E R+L+ D +DPYV +L K+K+K + T +P W E F F + +
Sbjct: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGH---QKYKSKIMPKTLNPQWREQFDFHLYEE 307
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEEL 134
V++++ +D+D+ DD + D+S L + K Q +GE L
Sbjct: 308 RGGVIDITAWDKDAGKRDDFIGRCQVDLS-ALSREQTHKLELQLEEGEGHL 357
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/95 (30%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L V+V+ A L AD+ ++DP+ +++L+ + T T+ +P WN+ F F I+
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNND---RLLTHTVYKNLNPEWNKVFTFNIK-D 683
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGK 118
+ +VLE+++YDED D KV + + G+
Sbjct: 684 IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGE 718
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/111 (27%), Positives = 57/111 (51%), Gaps = 4/111 (3%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
+++ ++E R+L+ D +DPYV +L K+K+K + T +P W E F F + +
Sbjct: 472 VSITLIEGRDLKAMDSNGLSDPYVKFRLGH---QKYKSKIMPKTLNPQWREQFDFHLYEE 528
Query: 84 VKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEEL 134
V++++ +D+D+ DD + D+S L + K Q +GE L
Sbjct: 529 RGGVIDITAWDKDAGKRDDFIGRCQVDLS-ALSREQTHKLELQLEEGEGHL 578
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGM--KFKTKTLTDTSHPVWNEAFRF-LI 80
L V V +A+NL D +DPYV L+L P K KTKT+ + +P WNE FRF L
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232
Query: 81 QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV 114
+S L + I+D D + +D + + ISE+
Sbjct: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGM--KFKTKTLTDTSHPVWNEAFRF-LI 80
L V V +A+NL D +DPYV L+L P K KTKT+ + +P WNE FRF L
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232
Query: 81 QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV 114
+S L + I+D D + +D + + ISE+
Sbjct: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 15/154 (9%)
Query: 21 CWQLTVRVLEARNLRWAD----LLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAF 76
C + V +LEA L D L ++DPY + + F+++T+ +P WNE F
Sbjct: 305 CGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGL---QHFRSRTIYRNLNPTWNEVF 361
Query: 77 RFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTF--SQSPQGEEEL 134
F++ LE+ +YDED+ DD + + +V+ +++ + F + + G L
Sbjct: 362 EFMVYEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL 420
Query: 135 DVEFL-----MEETSDRPENLITNKVIVARELSC 163
+E+L E ++ L T ++V E +C
Sbjct: 421 RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESAC 454
Score = 31.2 bits (69), Expect = 4.1
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 44 DPYVILQLSTAPGMKFKT-KTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDED 96
DP ++LS G K T KT PVW++ F F + + L L + D+D
Sbjct: 484 DPSSYVKLSV--GKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDD 535
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 51.2 bits (121), Expect = 4e-06
Identities = 33/124 (26%), Positives = 65/124 (52%), Gaps = 12/124 (9%)
Query: 24 LTVRVLEARNLRWAD------LLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFR 77
L + +EA++L+ D + ++DPY I+++ F+++ + + P WNE +
Sbjct: 359 LRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGN---QIFQSRVIKENLSPKWNEVYE 415
Query: 78 FLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRK--TFSQSPQGEEELD 135
L+ LE+ ++DED +DD ++ D+ EV +LL + T + P+G+ L
Sbjct: 416 ALVYEHPGQELEIELFDEDP-DKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLR 474
Query: 136 VEFL 139
+E+L
Sbjct: 475 LEWL 478
Score = 33.5 bits (75), Expect = 0.82
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 31 ARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLEL 90
ARNL +S ++P ++Q+S + ++K T+ PVW E F F I + + LE+
Sbjct: 517 ARNLPSGKKIS-SNPNPVVQMSVGHKAQ-ESKIRYKTNEPVWEENFTFFIHNPKRQDLEV 574
Query: 91 SIYDE 95
+ DE
Sbjct: 575 EVRDE 579
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQL--STAPGMKFKTKTLTDTSHPVWNEAFRF--- 78
L +++A+ L+ D ADPYV L L + K +TKTL +T +P+WNE +
Sbjct: 409 LQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGI 468
Query: 79 LIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFS 125
+ + L +S+ DED ++ + + + ++ P + RK F+
Sbjct: 469 TDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQ--RKNFN 513
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQL--STAPGMKFKTKTLTDTSHPVWNEAFRF--- 78
L +++A+ L+ D ADPYV L L + K +TKTL +T +P+WNE +
Sbjct: 405 LQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGI 464
Query: 79 LIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFS 125
+ + L +S+ DED ++ + + + ++ P + RK F+
Sbjct: 465 TDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQ--RKNFN 509
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 49.3 bits (116), Expect = 1e-05
Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 23 QLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLI-- 80
QLTV VL+A L D+ +DPYV + L K++TK T +P +NE F F +
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPY 214
Query: 81 QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFL 139
Q L ++IYD D ++ DI +V ++ V G+ + + + QG E+ + E L
Sbjct: 215 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW--RDLQGGEKEEPEKL 271
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/93 (33%), Positives = 53/93 (56%), Gaps = 6/93 (6%)
Query: 20 TCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLT---DTSHPVWNEAF 76
T +LTV +LEA+NL+ D+ +DPYV + L G + K K T T +P +NE+F
Sbjct: 283 TAGKLTVCILEAKNLKKMDVGGLSDPYVKIHL-MQNGKRLKKKKTTVKKKTLNPYFNESF 341
Query: 77 RFLIQ-SQVKNV-LELSIYDEDSVTEDDICFKV 107
F I Q++ V + +++ D D + +++ K+
Sbjct: 342 SFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKI 374
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 49.3 bits (116), Expect = 1e-05
Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 23 QLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLI-- 80
QLTV VL+A L D+ +DPYV + L K++TK T +P +NE F F +
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPY 214
Query: 81 QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFL 139
Q L ++IYD D ++ DI +V ++ V G+ + + + QG E+ + E L
Sbjct: 215 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW--RDLQGGEKEEPEKL 271
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/93 (33%), Positives = 53/93 (56%), Gaps = 6/93 (6%)
Query: 20 TCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLT---DTSHPVWNEAF 76
T +LTV +LEA+NL+ D+ +DPYV + L G + K K T T +P +NE+F
Sbjct: 283 TAGKLTVCILEAKNLKKMDVGGLSDPYVKIHL-MQNGKRLKKKKTTVKKKTLNPYFNESF 341
Query: 77 RFLIQ-SQVKNV-LELSIYDEDSVTEDDICFKV 107
F I Q++ V + +++ D D + +++ K+
Sbjct: 342 SFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKI 374
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 8/104 (7%)
Query: 15 QGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMK----FKTKTLTDTSHP 70
QGE+ L V+V+ +L D+ +DPYV L L A + +TKT+ T +P
Sbjct: 8 QGESRI---LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNP 64
Query: 71 VWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV 114
WNE F F + +L ++DE+ +T DD +V +S +
Sbjct: 65 KWNEEFYFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 107
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 8/104 (7%)
Query: 15 QGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMK----FKTKTLTDTSHP 70
QGE+ L V+V+ +L D+ +DPYV L L A + +TKT+ T +P
Sbjct: 8 QGESRI---LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNP 64
Query: 71 VWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV 114
WNE F F + +L ++DE+ +T DD +V +S +
Sbjct: 65 KWNEEFYFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 107
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 48.5 bits (114), Expect = 2e-05
Identities = 59/269 (21%), Positives = 114/269 (42%), Gaps = 31/269 (11%)
Query: 24 LTVRVLEARNLRWAD------LLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFR 77
+ + +L AR L D + ++DPY +++L T F ++ + + +P W E +
Sbjct: 331 IRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGT---QTFCSRVIDEELNPQWGETYE 387
Query: 78 FLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFS-QSPQGEEELDV 136
++ +E+ ++D+D +DD ++ D+ +VL +L F Q QG+ L +
Sbjct: 388 VMVHEVPGQEIEVEVFDKDP-DKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRL 446
Query: 137 EF--LMEETSDRPENLITNKVIVAR----ELSCLDVHLDSTGSTAVVADQD------KLE 184
E+ L+ + + L N + +R + L V+LD + +L
Sbjct: 447 EWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLS 506
Query: 185 LELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPL 244
++ V + S T+ AFRF EL +++ + + G LT+PL
Sbjct: 507 IQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDD-----SRALTLGALTLPL 561
Query: 245 RPLTIGKEVTMD---VPAPNAPGVRLQLK 270
L E+ +D + + P RL +K
Sbjct: 562 ARLLTAPELILDQWFQLSSSGPNSRLYMK 590
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 12/124 (9%)
Query: 24 LTVRVLEARNLRWAD------LLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFR 77
L + VLEA++L D + ++DPYV L+L+ G F++ + + +P WNE F
Sbjct: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLA---GRSFRSHVVREDLNPRWNEVFE 705
Query: 78 FLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRK--TFSQSPQGEEELD 135
++ S LE+ ++D+D + +DD + ++ VL L + T P G L
Sbjct: 706 VIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLR 764
Query: 136 VEFL 139
+E L
Sbjct: 765 LERL 768
Score = 37.7 bits (86), Expect = 0.043
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQ 83
L++ + A +L PY L T KTKT++ TS PVW+E+ FLI+
Sbjct: 800 LSIYMERAEDLPLRKGTKHLSPYATL---TVGDSSHKTKTISQTSAPVWDESASFLIRKP 856
Query: 84 VKNVLELSIYDE 95
LEL + E
Sbjct: 857 HTESLELQVRGE 868
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,861,994
Number of Sequences: 37866
Number of extensions: 1599027
Number of successful extensions: 4173
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 3952
Number of HSP's gapped (non-prelim): 223
length of query: 818
length of database: 18,247,518
effective HSP length: 111
effective length of query: 707
effective length of database: 14,044,392
effective search space: 9929385144
effective search space used: 9929385144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.